locus-tag	class	description
HB674_RS00010	COG0592	DNA-directed DNA polymerase activity
HB674_RS00015	COG2501	S4 domain
HB674_RS00030	COG0187	DNA topoisomerase II activity
HB674_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB674_RS00070	COG0517	IMP dehydrogenase activity
HB674_RS00070	COG0516	GMP reductase activity
HB674_RS00075	COG1686	Belongs to the peptidase S11 family
HB674_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
HB674_RS00105	COG1428	Deoxynucleoside kinase
HB674_RS00110	COG1428	Deoxynucleoside kinase
HB674_RS00115	COG3858	chitin binding
HB674_RS00115	COG1388	LysM domain
HB674_RS00120	COG1335	isochorismatase
HB674_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HB674_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB674_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HB674_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB674_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HB674_RS00195	COG3853	Toxic anion resistance protein (TelA)
HB674_RS00200	COG1982	Orn Lys Arg decarboxylase major
HB674_RS00210	COG3870	Protein conserved in bacteria
HB674_RS00215	COG1728	Protein conserved in bacteria
HB674_RS00220	COG0470	DNA polymerase III
HB674_RS00225	COG1774	PSP1 C-terminal conserved region
HB674_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HB674_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HB674_RS00250	COG2002	toxin-antitoxin pair type II binding
HB674_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB674_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB674_RS00260	COG0084	hydrolase, TatD family'
HB674_RS00265	COG3583	domain protein
HB674_RS00265	COG3584	3D domain protein
HB674_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HB674_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB674_RS00285	COG4466	Protein conserved in bacteria
HB674_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB674_RS00305	COG0251	oxidation-reduction process
HB674_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB674_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB674_RS00345	COG2002	toxin-antitoxin pair type II binding
HB674_RS00350	COG2244	polysaccharide biosynthetic process
HB674_RS00355	COG3956	TIGRFAM MazG family protein
HB674_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB674_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB674_RS00380	COG1098	S1 RNA binding domain
HB674_RS00395	COG2208	phosphoserine phosphatase activity
HB674_RS00400	COG2304	oxidoreductase activity
HB674_RS00405	COG0515	serine threonine protein kinase
HB674_RS00410	COG0037	tRNA processing
HB674_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB674_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB674_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB674_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB674_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HB674_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB674_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB674_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HB674_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB674_RS00475	COG1396	sequence-specific DNA binding
HB674_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB674_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HB674_RS00565	COG4463	regulation of RNA biosynthetic process
HB674_RS00570	COG3880	PFAM UvrB UvrC protein
HB674_RS00580	COG0542	response to heat
HB674_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HB674_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HB674_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HB674_RS00615	COG1045	serine acetyltransferase
HB674_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HB674_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB674_RS00635	COG3688	RNA-binding protein containing a PIN domain
HB674_RS00640	COG1595	DNA-templated transcription, initiation
HB674_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB674_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HB674_RS00680	COG2813	Specifically methylates the guanine in position
HB674_RS00695	COG1358	cellular component organization or biogenesis
HB674_RS00720	COG0596	Alpha beta hydrolase
HB674_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HB674_RS00830	COG0201	protein transport
HB674_RS00840	COG0024	Methionine aminopeptidase
HB674_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HB674_RS00880	COG1122	ATPase activity
HB674_RS00885	COG1122	ATPase activity
HB674_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HB674_RS00910	COG2226	methyltransferase
HB674_RS00915	COG2318	DinB family
HB674_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS00930	COG0489	protein tyrosine kinase activity
HB674_RS00940	COG2194	sulfuric ester hydrolase activity
HB674_RS00945	COG0726	polysaccharide deacetylase
HB674_RS01005	COG0738	Major facilitator superfamily
HB674_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB674_RS01020	COG1063	alcohol dehydrogenase
HB674_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
HB674_RS01030	COG0385	Bile acid
HB674_RS01035	COG2819	hydrolase of the alpha beta superfamily
HB674_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB674_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB674_RS01055	COG2207	Transcriptional regulator
HB674_RS01060	COG3876	Protein conserved in bacteria
HB674_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
HB674_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB674_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS01075	COG1263	PTS System
HB674_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB674_RS01090	COG1683	Conserved Protein
HB674_RS01120	COG1595	DNA-templated transcription, initiation
HB674_RS01125	COG5662	AntiSigma factor
HB674_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HB674_RS01135	COG4856	YbbR-like protein
HB674_RS01170	COG5002	protein histidine kinase activity
HB674_RS01175	COG1136	(ABC) transporter
HB674_RS01180	COG0577	efflux transmembrane transporter activity
HB674_RS01200	COG1346	cytolysis
HB674_RS01205	COG1380	Effector of murein hydrolase LrgA
HB674_RS01210	COG1846	Transcriptional regulator
HB674_RS01215	COG1113	amino acid transport
HB674_RS01220	COG1011	Hydrolase
HB674_RS01225	COG4585	Histidine kinase
HB674_RS01230	COG2197	response regulator
HB674_RS01235	COG1131	(ABC) transporter
HB674_RS01275	COG0531	amino acid
HB674_RS01280	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HB674_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
HB674_RS01300	COG2271	Major facilitator Superfamily
HB674_RS01310	COG2368	4-hydroxyphenylacetate
HB674_RS01320	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS01335	COG1397	ADP-ribosylglycohydrolase
HB674_RS01340	COG5444	nuclease activity
HB674_RS01350	COG0371	Dehydrogenase
HB674_RS01360	COG1183	phosphatidylcholine synthase activity
HB674_RS01365	COG0586	Pfam SNARE associated Golgi protein
HB674_RS01370	COG0688	phosphatidylethanolamine metabolic process
HB674_RS01385	COG1301	dicarboxylic acid transport
HB674_RS01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB674_RS01395	COG0833	amino acid
HB674_RS01400	COG2040	homocysteine
HB674_RS01405	COG1115	amino acid carrier protein
HB674_RS01410	COG2066	Belongs to the glutaminase family
HB674_RS01415	COG4191	Histidine kinase
HB674_RS01420	COG0784	Response regulator, receiver
HB674_RS01440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB674_RS01445	COG0778	Nitroreductase
HB674_RS01450	COG0346	lactoylglutathione lyase activity
HB674_RS01455	COG2259	Doxx family
HB674_RS01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS01475	COG3773	Cell wall hydrolase
HB674_RS01480	COG3540	Alkaline phosphatase
HB674_RS01485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB674_RS01490	COG0805	protein transport
HB674_RS01500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB674_RS01505	COG0477	Major facilitator Superfamily
HB674_RS01510	COG1309	transcriptional regulator
HB674_RS01515	COG0252	asparaginase activity
HB674_RS01520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HB674_RS01525	COG3012	SEC-C Motif Domain Protein
HB674_RS01525	COG1405	negative regulation of cell septum assembly
HB674_RS01540	COG1595	DNA-templated transcription, initiation
HB674_RS01545	COG1595	DNA-templated transcription, initiation
HB674_RS01550	COG1876	peptidase activity
HB674_RS01555	COG0457	Tetratricopeptide repeat
HB674_RS01560	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS01565	COG0366	Alpha amylase catalytic
HB674_RS01570	COG0803	Belongs to the bacterial solute-binding protein 9 family
HB674_RS01575	COG1121	(ABC) transporter
HB674_RS01580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB674_RS01585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS01590	COG2310	stress, protein
HB674_RS01595	COG2310	stress, protein
HB674_RS01600	COG2310	stress, protein
HB674_RS01605	COG0861	Integral membrane protein TerC family
HB674_RS01615	COG3853	Toxic anion resistance protein (TelA)
HB674_RS01620	COG0477	Major facilitator Superfamily
HB674_RS01625	COG4175	Glycine betaine
HB674_RS01625	COG0517	IMP dehydrogenase activity
HB674_RS01630	COG4176	ABC-type proline glycine betaine transport system permease component
HB674_RS01635	COG2113	Glycine betaine
HB674_RS01640	COG1473	amidohydrolase
HB674_RS01645	COG1288	antiporter activity
HB674_RS01665	COG2814	Major facilitator Superfamily
HB674_RS01670	COG1846	Transcriptional regulator
HB674_RS01675	COG1280	lysine exporter protein (LysE YggA)
HB674_RS01680	COG3403	YqcI/YcgG family
HB674_RS01685	COG1113	amino acid transport
HB674_RS01690	COG3665	Urea carboxylase-associated protein
HB674_RS01705	COG1660	Displays ATPase and GTPase activities
HB674_RS01710	COG1082	Xylose isomerase domain protein TIM barrel
HB674_RS01715	COG2271	Major facilitator Superfamily
HB674_RS01720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB674_RS01725	COG3458	cephalosporin-C deacetylase activity
HB674_RS01730	COG3541	Predicted nucleotidyltransferase
HB674_RS01735	COG0506	proline dehydrogenase activity
HB674_RS01740	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS01745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB674_RS01750	COG2508	Transcriptional regulator
HB674_RS01760	COG1587	Uroporphyrinogen-III synthase
HB674_RS01760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB674_RS01765	COG2146	nitrite reductase [NAD(P)H] activity
HB674_RS01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB674_RS01775	COG0243	molybdopterin cofactor binding
HB674_RS01780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB674_RS01785	COG2223	nitrite transmembrane transporter activity
HB674_RS01790	COG0523	cobalamin synthesis protein
HB674_RS01795	COG1063	alcohol dehydrogenase
HB674_RS01800	COG1714	RDD family
HB674_RS01810	COG2723	6-phospho-beta-galactosidase activity
HB674_RS01825	COG3209	COG3209 Rhs family protein
HB674_RS01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB674_RS01835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HB674_RS01840	COG1733	regulation of RNA biosynthetic process
HB674_RS01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS01860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB674_RS01875	COG2364	Membrane
HB674_RS01880	COG1126	abc transporter atp-binding protein
HB674_RS01885	COG0765	amino acid transport
HB674_RS01895	COG0583	DNA-binding transcription factor activity
HB674_RS01900	COG0163	prenyltransferase activity
HB674_RS01905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HB674_RS01920	COG3104	oligopeptide transport
HB674_RS01925	COG5434	Belongs to the glycosyl hydrolase 28 family
HB674_RS01935	COG0697	spore germination
HB674_RS01945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB674_RS01950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS01955	COG0456	acetyltransferase
HB674_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB674_RS01965	COG0765	amino acid transport
HB674_RS01970	COG1126	abc transporter atp-binding protein
HB674_RS01975	COG1473	amidohydrolase
HB674_RS01980	COG2079	MmgE PrpD family protein
HB674_RS01985	COG1136	(ABC) transporter
HB674_RS01990	COG0577	efflux transmembrane transporter activity
HB674_RS01995	COG0745	RESPONSE REGULATOR receiver
HB674_RS02000	COG5002	protein histidine kinase activity
HB674_RS02000	COG3850	Histidine kinase
HB674_RS02005	COG0457	Tetratricopeptide repeat
HB674_RS02020	COG0527	aspartate kinase activity
HB674_RS02025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS02030	COG4605	iron ion homeostasis
HB674_RS02035	COG4604	ABC transporter, ATP-binding protein
HB674_RS02040	COG4607	ABC-type enterochelin transport system periplasmic component
HB674_RS02045	COG2814	Major facilitator Superfamily
HB674_RS02050	COG1309	transcriptional regulator
HB674_RS02055	COG0778	Nitroreductase
HB674_RS02060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB674_RS02065	COG0640	Transcriptional regulator
HB674_RS02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS02075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB674_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS02085	COG4975	Glucose uptake
HB674_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS02095	COG4549	nuclear export factor GLE1
HB674_RS02100	COG1276	copper resistance
HB674_RS02100	COG2372	response to copper ion
HB674_RS02105	COG1349	DNA-binding transcription factor activity
HB674_RS02115	COG2213	PTS system mannitol-specific
HB674_RS02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS02130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB674_RS02140	COG0561	phosphatase activity
HB674_RS02150	COG1914	H( )-stimulated, divalent metal cation uptake system
HB674_RS02160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HB674_RS02165	COG1984	allophanate hydrolase subunit 2
HB674_RS02170	COG1414	Transcriptional regulator
HB674_RS02175	COG2755	lipolytic protein G-D-S-L family
HB674_RS02185	COG2329	Antibiotic biosynthesis monooxygenase
HB674_RS02190	COG0768	penicillin binding
HB674_RS02195	COG4989	oxidoreductase activity
HB674_RS02200	COG3711	transcriptional antiterminator
HB674_RS02205	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS02215	COG1917	Cupin 2, conserved barrel domain protein
HB674_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB674_RS02225	COG3871	stress protein (general stress protein 26)
HB674_RS02235	COG2814	Major facilitator Superfamily
HB674_RS02240	COG1522	sequence-specific DNA binding
HB674_RS02245	COG0551	DNA topoisomerase type I activity
HB674_RS02245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB674_RS02250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HB674_RS02255	COG3706	GGDEF domain
HB674_RS02260	COG5298	Protein conserved in bacteria
HB674_RS02265	COG1215	transferase activity, transferring glycosyl groups
HB674_RS02275	COG0531	amino acid
HB674_RS02285	COG0028	Belongs to the TPP enzyme family
HB674_RS02310	COG0457	Tetratricopeptide repeat
HB674_RS02335	COG1914	H( )-stimulated, divalent metal cation uptake system
HB674_RS02345	COG4876	unkown
HB674_RS02355	COG2076	Multidrug Resistance protein
HB674_RS02360	COG2217	Heavy metal translocating P-type atpase
HB674_RS02365	COG3729	General stress protein
HB674_RS02370	COG0662	Cupin 2, conserved barrel domain protein
HB674_RS02375	COG2329	Antibiotic biosynthesis monooxygenase
HB674_RS02380	COG3546	catalase activity
HB674_RS02385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB674_RS02390	COG3290	protein histidine kinase activity
HB674_RS02395	COG4565	transcriptional regulatory protein
HB674_RS02400	COG1301	dicarboxylic acid transport
HB674_RS02405	COG0628	permease
HB674_RS02410	COG1131	(ABC) transporter
HB674_RS02415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HB674_RS02425	COG1960	acyl-CoA dehydrogenase activity
HB674_RS02440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB674_RS02445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS02455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB674_RS02460	COG0513	Belongs to the DEAD box helicase family
HB674_RS02465	COG3402	PFAM membrane-flanked domain
HB674_RS02470	COG3428	Bacterial PH domain
HB674_RS02475	COG0705	Rhomboid family
HB674_RS02485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB674_RS02490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB674_RS02495	COG0864	Transcriptional regulator
HB674_RS02500	COG2337	Toxic component of a toxin-antitoxin (TA) module
HB674_RS02505	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS02510	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS02515	COG2172	sigma factor antagonist activity
HB674_RS02520	COG2208	phosphoserine phosphatase activity
HB674_RS02525	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS02535	COG1191	sigma factor activity
HB674_RS02540	COG2208	phosphoserine phosphatase activity
HB674_RS02545	COG2183	response to ionizing radiation
HB674_RS02610	COG5444	nuclease activity
HB674_RS02615	COG0457	Tetratricopeptide repeat
HB674_RS02630	COG0477	Major facilitator Superfamily
HB674_RS02635	COG1846	Transcriptional regulator
HB674_RS02645	COG2030	dehydratase
HB674_RS02660	COG1959	2 iron, 2 sulfur cluster binding
HB674_RS02665	COG2910	NAD(P)H-binding
HB674_RS02680	COG1278	Cold shock
HB674_RS02685	COG1329	Transcriptional regulator
HB674_RS02690	COG1937	Protein conserved in bacteria
HB674_RS02695	COG2210	Belongs to the sulfur carrier protein TusA family
HB674_RS02705	COG0425	Belongs to the sulfur carrier protein TusA family
HB674_RS02705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB674_RS02710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS02710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB674_RS02715	COG0425	Belongs to the sulfur carrier protein TusA family
HB674_RS02720	COG0730	response to heat
HB674_RS02725	COG1794	racemase activity, acting on amino acids and derivatives
HB674_RS02740	COG3621	Patatin-like phospholipase
HB674_RS02750	COG0662	Cupin 2, conserved barrel domain protein
HB674_RS02765	COG0277	FAD linked oxidase domain protein
HB674_RS02790	COG0662	Cupin 2, conserved barrel domain protein
HB674_RS02795	COG2318	DinB family
HB674_RS02830	COG1064	alcohol dehydrogenase
HB674_RS02835	COG0789	Transcriptional regulator
HB674_RS02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS02860	COG2814	Major facilitator Superfamily
HB674_RS02865	COG1309	transcriptional regulator
HB674_RS02870	COG0697	spore germination
HB674_RS02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS02880	COG5577	PFAM Coat F domain
HB674_RS02890	COG1063	alcohol dehydrogenase
HB674_RS02895	COG5577	PFAM Coat F domain
HB674_RS02905	COG4585	Histidine kinase
HB674_RS02910	COG2197	response regulator
HB674_RS02915	COG2409	Drug exporters of the RND superfamily
HB674_RS02920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HB674_RS02930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB674_RS02935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS02945	COG2814	Major facilitator Superfamily
HB674_RS02950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB674_RS02960	COG0730	response to heat
HB674_RS02965	COG0456	acetyltransferase
HB674_RS02970	COG0789	Transcriptional regulator
HB674_RS02970	COG4978	Transcriptional regulator
HB674_RS02975	COG0697	spore germination
HB674_RS02980	COG1051	belongs to the nudix hydrolase family
HB674_RS02985	COG2226	methyltransferase
HB674_RS02990	COG0473	3-isopropylmalate dehydrogenase activity
HB674_RS02995	COG1802	Transcriptional regulator
HB674_RS03000	COG1819	glycosyl
HB674_RS03015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB674_RS03025	COG1388	LysM domain
HB674_RS03030	COG2814	Major facilitator Superfamily
HB674_RS03035	COG2188	Transcriptional regulator
HB674_RS03040	COG2186	Transcriptional regulator
HB674_RS03045	COG2807	transmembrane transport
HB674_RS03050	COG2076	Multidrug Resistance protein
HB674_RS03055	COG2076	Multidrug Resistance protein
HB674_RS03060	COG1309	transcriptional regulator
HB674_RS03065	COG0531	amino acid
HB674_RS03075	COG3832	glyoxalase III activity
HB674_RS03080	COG0604	alcohol dehydrogenase
HB674_RS03085	COG2814	Major facilitator Superfamily
HB674_RS03125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB674_RS03130	COG0802	atpase or kinase
HB674_RS03135	COG1214	PFAM Peptidase M22, glycoprotease
HB674_RS03140	COG0456	acetyltransferase
HB674_RS03145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB674_RS03150	COG0488	(ABC) transporter
HB674_RS03165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB674_RS03170	COG0805	protein transport
HB674_RS03180	COG1266	CAAX protease self-immunity
HB674_RS03220	COG0457	Tetratricopeptide repeat
HB674_RS03225	COG1063	alcohol dehydrogenase
HB674_RS03230	COG2211	Major facilitator Superfamily
HB674_RS03235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB674_RS03245	COG1842	Phage shock protein A
HB674_RS03250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB674_RS03255	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB674_RS03260	COG4260	virion core protein, lumpy skin disease virus
HB674_RS03265	COG2755	lipolytic protein G-D-S-L family
HB674_RS03265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB674_RS03275	COG1595	DNA-templated transcription, initiation
HB674_RS03280	COG1063	alcohol dehydrogenase
HB674_RS03285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB674_RS03290	COG0823	Involved in the tonB-independent uptake of proteins
HB674_RS03300	COG2132	Multicopper oxidase
HB674_RS03305	COG1113	amino acid transport
HB674_RS03310	COG0714	Associated with various cellular activities
HB674_RS03315	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HB674_RS03320	COG1305	Transglutaminase-like
HB674_RS03345	COG2252	PERMEase
HB674_RS03350	COG3064	Membrane
HB674_RS03370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HB674_RS03375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB674_RS03380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB674_RS03385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB674_RS03390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB674_RS03405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB674_RS03415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB674_RS03420	COG0138	bifunctional purine biosynthesis protein purh
HB674_RS03425	COG0151	Belongs to the GarS family
HB674_RS03435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB674_RS03440	COG1470	cell adhesion involved in biofilm formation
HB674_RS03445	COG4496	protein, YerC YecD
HB674_RS03450	COG0069	glutamate synthase activity
HB674_RS03460	COG0210	DNA helicase
HB674_RS03470	COG4851	CamS sex pheromone cAM373 precursor
HB674_RS03475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB674_RS03480	COG1285	pathogenesis
HB674_RS03485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB674_RS03505	COG1309	transcriptional regulator
HB674_RS03510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB674_RS03515	COG1597	lipid kinase activity
HB674_RS03520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB674_RS03530	COG1131	(ABC) transporter
HB674_RS03570	COG5444	nuclease activity
HB674_RS03600	COG3546	catalase activity
HB674_RS03605	COG0454	-acetyltransferase
HB674_RS03615	COG2323	membrane
HB674_RS03620	COG2329	Antibiotic biosynthesis monooxygenase
HB674_RS03625	COG0346	lactoylglutathione lyase activity
HB674_RS03630	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS03635	COG5583	Uncharacterized small protein (DUF2292)
HB674_RS03640	COG0196	riboflavin kinase activity
HB674_RS03645	COG0670	Belongs to the BI1 family
HB674_RS03650	COG1846	Transcriptional regulator
HB674_RS03655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB674_RS03665	COG2124	cytochrome p450
HB674_RS03665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB674_RS03670	COG1368	sulfuric ester hydrolase activity
HB674_RS03675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB674_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS03685	COG1442	glycosyl transferase family 8
HB674_RS03690	COG1216	Glycosyl transferase, family 2
HB674_RS03695	COG1442	glycosyl transferase family 8
HB674_RS03700	COG2223	nitrite transmembrane transporter activity
HB674_RS03705	COG0531	amino acid
HB674_RS03710	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS03715	COG0840	transmembrane signaling receptor activity
HB674_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS03725	COG0463	Glycosyl transferase, family 2
HB674_RS03725	COG0457	Tetratricopeptide repeat
HB674_RS03730	COG0488	(ABC) transporter
HB674_RS03735	COG0789	Transcriptional regulator
HB674_RS03740	COG2814	Major facilitator Superfamily
HB674_RS03745	COG0488	(ABC) transporter
HB674_RS03750	COG0513	Belongs to the DEAD box helicase family
HB674_RS03755	COG0456	acetyltransferase
HB674_RS03760	COG2130	NADP-dependent
HB674_RS03775	COG3866	Pectate lyase
HB674_RS03780	COG0471	metal ion transport
HB674_RS03800	COG3290	protein histidine kinase activity
HB674_RS03805	COG4565	transcriptional regulatory protein
HB674_RS03810	COG3181	Tripartite tricarboxylate transporter family receptor
HB674_RS03815	COG2851	Citrate transporter
HB674_RS03820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS03825	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HB674_RS03835	COG2258	MOSC domain
HB674_RS03855	COG0024	Methionine aminopeptidase
HB674_RS03860	COG1263	PTS System
HB674_RS03860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS03870	COG1368	sulfuric ester hydrolase activity
HB674_RS03880	COG0071	Belongs to the small heat shock protein (HSP20) family
HB674_RS03895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS03895	COG1263	PTS System
HB674_RS03900	COG0366	Alpha amylase catalytic
HB674_RS03905	COG2188	Transcriptional regulator
HB674_RS03910	COG0778	Nitroreductase
HB674_RS03925	COG0737	Belongs to the 5'-nucleotidase family
HB674_RS03930	COG0693	protein deglycase activity
HB674_RS03935	COG1609	Transcriptional regulator
HB674_RS03950	COG2814	Major facilitator Superfamily
HB674_RS03960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB674_RS03965	COG4980	gas vesicle protein
HB674_RS03970	COG1295	ribonuclease BN
HB674_RS03975	COG0477	Major facilitator Superfamily
HB674_RS03980	COG0387	Pfam Sodium calcium exchanger
HB674_RS03990	COG0668	transmembrane transport
HB674_RS03995	COG0535	radical SAM domain protein
HB674_RS04005	COG0726	polysaccharide deacetylase
HB674_RS04025	COG0745	RESPONSE REGULATOR receiver
HB674_RS04030	COG2205	protein histidine kinase activity
HB674_RS04035	COG2084	Dehydrogenase
HB674_RS04045	COG0598	Magnesium transport protein CorA
HB674_RS04050	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HB674_RS04055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB674_RS04070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB674_RS04075	COG4637	Psort location Cytoplasmic, score
HB674_RS04080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB674_RS04085	COG0022	dehydrogenase e1 component
HB674_RS04090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB674_RS04095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB674_RS04100	COG3284	Transcriptional regulator
HB674_RS04110	COG1486	melibiose metabolic process
HB674_RS04115	COG1737	Transcriptional regulator
HB674_RS04120	COG1263	PTS System
HB674_RS04120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS04130	COG1132	(ABC) transporter
HB674_RS04135	COG1132	(ABC) transporter
HB674_RS04140	COG2259	Doxx family
HB674_RS04145	COG2514	catechol 2,3-dioxygenase activity
HB674_RS04155	COG1695	Transcriptional regulator
HB674_RS04160	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB674_RS04165	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HB674_RS04170	COG3848	Pyruvate phosphate dikinase
HB674_RS04170	COG0574	Belongs to the PEP-utilizing enzyme family
HB674_RS04175	COG2732	(Barnase) inhibitor
HB674_RS04180	COG2318	DinB family
HB674_RS04185	COG2814	Major facilitator Superfamily
HB674_RS04190	COG1846	Transcriptional regulator
HB674_RS04195	COG0392	lysyltransferase activity
HB674_RS04195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HB674_RS04200	COG0384	phenazine biosynthesis protein PhzF
HB674_RS04205	COG0778	Nitroreductase
HB674_RS04220	COG1090	epimerase
HB674_RS04235	COG2814	Major facilitator Superfamily
HB674_RS04245	COG3591	Belongs to the peptidase S1B family
HB674_RS04260	COG3103	Sh3 type 3 domain protein
HB674_RS04265	COG5658	integral membrane protein
HB674_RS04270	COG0596	Alpha beta hydrolase
HB674_RS04275	COG0463	Glycosyl transferase, family 2
HB674_RS04280	COG4485	Bacterial membrane protein, YfhO
HB674_RS04285	COG1988	membrane-bound metal-dependent
HB674_RS04290	COG1194	a g-specific adenine glycosylase
HB674_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS04320	COG1132	(ABC) transporter
HB674_RS04325	COG4129	membrane
HB674_RS04335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB674_RS04340	COG0735	belongs to the Fur family
HB674_RS04455	COG3340	Belongs to the peptidase S51 family
HB674_RS04465	COG0277	FAD linked oxidase domain protein
HB674_RS04475	COG0747	negative chemotaxis
HB674_RS04480	COG0601	transmembrane transport
HB674_RS04485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB674_RS04490	COG0444	Belongs to the ABC transporter superfamily
HB674_RS04495	COG4608	Belongs to the ABC transporter superfamily
HB674_RS04500	COG0753	catalase activity
HB674_RS04510	COG1116	anion transmembrane transporter activity
HB674_RS04515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB674_RS04520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB674_RS04540	COG1476	TRANSCRIPTIONal
HB674_RS04550	COG3382	B3 4 domain protein
HB674_RS04555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB674_RS04565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB674_RS04570	COG0789	Transcriptional regulator
HB674_RS04575	COG1664	Polymer-forming cytoskeletal
HB674_RS04580	COG1664	Polymer-forming cytoskeletal
HB674_RS04585	COG2766	serine protein kinase
HB674_RS04595	COG1846	Transcriptional regulator
HB674_RS04600	COG1566	PFAM secretion protein HlyD family protein
HB674_RS04605	COG2814	Major facilitator Superfamily
HB674_RS04610	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB674_RS04625	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HB674_RS04630	COG1278	Cold shock
HB674_RS04635	COG1464	Belongs to the NlpA lipoprotein family
HB674_RS04640	COG3706	GGDEF domain
HB674_RS04645	COG1823	symporter activity
HB674_RS04665	COG5577	PFAM Coat F domain
HB674_RS04670	COG0737	Belongs to the 5'-nucleotidase family
HB674_RS04670	COG1525	nuclease
HB674_RS04670	COG4085	toxin activity
HB674_RS04675	COG3764	Sortase (surface protein transpeptidase)
HB674_RS04680	COG0564	pseudouridine synthase activity
HB674_RS04690	COG0517	IMP dehydrogenase activity
HB674_RS04695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB674_RS04700	COG3153	acetyltransferase
HB674_RS04700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB674_RS04705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB674_RS04710	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HB674_RS04715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB674_RS04725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HB674_RS04730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB674_RS04735	COG2203	Gaf domain
HB674_RS04735	COG4585	Histidine kinase
HB674_RS04740	COG2197	response regulator
HB674_RS04745	COG0431	NADPH-dependent FMN reductase
HB674_RS04760	COG0791	NLP P60 protein
HB674_RS04760	COG1388	LysM domain
HB674_RS04765	COG1959	2 iron, 2 sulfur cluster binding
HB674_RS04770	COG0668	transmembrane transport
HB674_RS04775	COG2719	SpoVR family
HB674_RS04780	COG1785	Belongs to the alkaline phosphatase family
HB674_RS04785	COG1388	LysM domain
HB674_RS04785	COG0791	NLP P60 protein
HB674_RS04790	COG0583	DNA-binding transcription factor activity
HB674_RS04795	COG0372	Belongs to the citrate synthase family
HB674_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS04805	COG0531	amino acid
HB674_RS04810	COG0733	neurotransmitter:sodium symporter activity
HB674_RS04825	COG1595	DNA-templated transcription, initiation
HB674_RS04830	COG0204	Acyl-transferase
HB674_RS04835	COG1253	flavin adenine dinucleotide binding
HB674_RS04840	COG0789	Transcriptional regulator
HB674_RS04845	COG0436	Aminotransferase
HB674_RS04850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB674_RS04855	COG1253	flavin adenine dinucleotide binding
HB674_RS04860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB674_RS04865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB674_RS04870	COG0584	glycerophosphoryl diester phosphodiesterase
HB674_RS04880	COG0668	transmembrane transport
HB674_RS04885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB674_RS04890	COG0726	polysaccharide deacetylase
HB674_RS04895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB674_RS04900	COG3226	Transcriptional regulator
HB674_RS04910	COG0589	response to stress
HB674_RS04915	COG1132	(ABC) transporter
HB674_RS04920	COG1132	(ABC) transporter
HB674_RS04925	COG0702	epimerase
HB674_RS04940	COG0189	ligase activity
HB674_RS04945	COG0189	ligase activity
HB674_RS04960	COG4335	DNA alkylation repair
HB674_RS04965	COG0561	phosphatase activity
HB674_RS04970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB674_RS04980	COG0475	glutathione-regulated potassium exporter activity
HB674_RS04985	COG0490	domain, Protein
HB674_RS04995	COG1024	Enoyl-CoA hydratase
HB674_RS05005	COG4152	abc transporter atp-binding protein
HB674_RS05010	COG1668	transmembrane transport
HB674_RS05015	COG0420	3'-5' exonuclease activity
HB674_RS05020	COG4717	serine-type aminopeptidase activity
HB674_RS05035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB674_RS05070	COG4980	gas vesicle protein
HB674_RS05085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB674_RS05090	COG0537	adenosine 5'-monophosphoramidase activity
HB674_RS05095	COG1131	(ABC) transporter
HB674_RS05100	COG4473	ABC transporter
HB674_RS05110	COG1473	amidohydrolase
HB674_RS05115	COG3069	C4-dicarboxylate transmembrane transporter activity
HB674_RS05120	COG2329	Antibiotic biosynthesis monooxygenase
HB674_RS05125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB674_RS05145	COG1309	transcriptional regulator
HB674_RS05150	COG1511	domain protein
HB674_RS05155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB674_RS05165	COG1363	Peptidase, m42
HB674_RS05170	COG1301	dicarboxylic acid transport
HB674_RS05180	COG1234	tRNA 3'-trailer cleavage
HB674_RS05185	COG0095	Lipoate-protein ligase
HB674_RS05190	COG0702	epimerase
HB674_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS05205	COG0501	Belongs to the peptidase M48B family
HB674_RS05210	COG1404	Belongs to the peptidase S8 family
HB674_RS05220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HB674_RS05225	COG0406	alpha-ribazole phosphatase activity
HB674_RS05230	COG0183	Belongs to the thiolase family
HB674_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS05240	COG1268	BioY protein
HB674_RS05245	COG0840	transmembrane signaling receptor activity
HB674_RS05250	COG0723	plastoquinol--plastocyanin reductase activity
HB674_RS05250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB674_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS05265	COG4903	ComK protein
HB674_RS05275	COG5646	InterPro IPR014922
HB674_RS05295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB674_RS05310	COG0398	Pfam SNARE associated Golgi protein
HB674_RS05315	COG0681	Belongs to the peptidase S26 family
HB674_RS05320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB674_RS05325	COG1846	Transcriptional regulator
HB674_RS05330	COG3180	Ammonia monooxygenase
HB674_RS05335	COG2814	Major facilitator Superfamily
HB674_RS05345	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HB674_RS05350	COG2323	membrane
HB674_RS05365	COG0420	3'-5' exonuclease activity
HB674_RS05370	COG0419	ATPase involved in DNA repair
HB674_RS05375	COG1403	HNH endonuclease
HB674_RS05415	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB674_RS05430	COG0367	asparagine synthase
HB674_RS05435	COG1562	ergosterol biosynthetic process
HB674_RS05440	COG0534	Mate efflux family protein
HB674_RS05445	COG2207	Transcriptional regulator
HB674_RS05445	COG1917	Cupin 2, conserved barrel domain protein
HB674_RS05455	COG2318	DinB family
HB674_RS05460	COG1279	arginine transmembrane transporter activity
HB674_RS05465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS05470	COG1357	PFAM Pentapeptide repeats (8 copies)
HB674_RS05475	COG2153	protein acetylation
HB674_RS05480	COG0646	methionine synthase
HB674_RS05480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB674_RS05490	COG2996	Protein conserved in bacteria
HB674_RS05500	COG0840	transmembrane signaling receptor activity
HB674_RS05505	COG2124	cytochrome p450
HB674_RS05515	COG1307	EDD domain protein, DegV family
HB674_RS05520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS05540	COG0561	phosphatase activity
HB674_RS05545	COG1073	alpha beta
HB674_RS05550	COG2151	metal-sulfur cluster biosynthetic enzyme
HB674_RS05560	COG0277	FAD linked oxidase domain protein
HB674_RS05565	COG2271	Major facilitator Superfamily
HB674_RS05575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB674_RS05585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB674_RS05590	COG0505	Belongs to the CarA family
HB674_RS05595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB674_RS05600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB674_RS05615	COG2267	carboxylic ester hydrolase activity
HB674_RS05625	COG1744	ABC transporter substrate-binding protein PnrA-like
HB674_RS05640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB674_RS05645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB674_RS05650	COG5504	Zn-dependent protease
HB674_RS05655	COG0444	Belongs to the ABC transporter superfamily
HB674_RS05660	COG4608	Belongs to the ABC transporter superfamily
HB674_RS05670	COG0601	transmembrane transport
HB674_RS05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB674_RS05685	COG0180	Tryptophanyl-tRNA synthetase
HB674_RS05690	COG4166	transmembrane transport
HB674_RS05695	COG0601	transmembrane transport
HB674_RS05700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB674_RS05705	COG0444	Belongs to the ABC transporter superfamily
HB674_RS05710	COG4608	Belongs to the ABC transporter superfamily
HB674_RS05720	COG0456	acetyltransferase
HB674_RS05725	COG1393	Belongs to the ArsC family
HB674_RS05730	COG0861	Integral membrane protein TerC family
HB674_RS05735	COG4862	establishment of competence for transformation
HB674_RS05740	COG4469	Competence protein
HB674_RS05745	COG1164	Oligoendopeptidase f
HB674_RS05760	COG2346	COG2346, Truncated hemoglobins
HB674_RS05765	COG0741	lytic transglycosylase activity
HB674_RS05770	COG4116	CYTH
HB674_RS05780	COG2357	RelA SpoT domain protein
HB674_RS05785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB674_RS05790	COG0564	pseudouridine synthase activity
HB674_RS05800	COG0569	domain protein
HB674_RS05800	COG0475	glutathione-regulated potassium exporter activity
HB674_RS05805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB674_RS05810	COG0352	thiamine-phosphate diphosphorylase activity
HB674_RS05815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB674_RS05820	COG2104	thiamine diphosphate biosynthetic process
HB674_RS05830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB674_RS05835	COG0351	phosphomethylpyrimidine kinase
HB674_RS05840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB674_RS05895	COG0210	DNA helicase
HB674_RS05915	COG1131	(ABC) transporter
HB674_RS05925	COG2153	protein acetylation
HB674_RS05935	COG2382	esterase
HB674_RS05940	COG0626	cystathionine gamma-synthase activity
HB674_RS05945	COG0626	cystathionine gamma-synthase activity
HB674_RS05975	COG5444	nuclease activity
HB674_RS05985	COG0346	lactoylglutathione lyase activity
HB674_RS05990	COG2367	Beta-lactamase
HB674_RS05995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB674_RS06000	COG0477	Major facilitator Superfamily
HB674_RS06005	COG1846	Transcriptional regulator
HB674_RS06015	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HB674_RS06020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB674_RS06025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HB674_RS06030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS06030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS06035	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB674_RS06045	COG1349	DNA-binding transcription factor activity
HB674_RS06065	COG1285	pathogenesis
HB674_RS06080	COG2205	protein histidine kinase activity
HB674_RS06090	COG3383	formate dehydrogenase (NAD+) activity
HB674_RS06095	COG2427	Protein of unknown function (DUF1641)
HB674_RS06100	COG2124	cytochrome p450
HB674_RS06105	COG1819	glycosyl
HB674_RS06115	COG1587	Uroporphyrinogen-III synthase
HB674_RS06120	COG0390	transport system, permease component
HB674_RS06125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB674_RS06130	COG0697	spore germination
HB674_RS06135	COG4297	protein containing double-stranded beta helix domain
HB674_RS06145	COG1252	NADH dehydrogenase
HB674_RS06155	COG2211	Major facilitator Superfamily
HB674_RS06160	COG1609	Transcriptional regulator
HB674_RS06165	COG0246	Mannitol dehydrogenase
HB674_RS06170	COG2721	sulfolactate sulfo-lyase activity
HB674_RS06175	COG0745	RESPONSE REGULATOR receiver
HB674_RS06180	COG2205	protein histidine kinase activity
HB674_RS06180	COG2770	Histidine kinase
HB674_RS06200	COG4585	Histidine kinase
HB674_RS06205	COG2197	response regulator
HB674_RS06240	COG0730	response to heat
HB674_RS06245	COG2318	DinB family
HB674_RS06250	COG0457	Tetratricopeptide repeat
HB674_RS06260	COG1388	LysM domain
HB674_RS06260	COG5632	N-Acetylmuramoyl-L-alanine amidase
HB674_RS06260	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS06270	COG4195	phage-related replication protein
HB674_RS06275	COG2856	Zn peptidase
HB674_RS06280	COG1396	sequence-specific DNA binding
HB674_RS06290	COG1522	sequence-specific DNA binding
HB674_RS06295	COG1484	DNA-dependent DNA replication
HB674_RS06315	COG1595	DNA-templated transcription, initiation
HB674_RS06320	COG3728	DNA packaging
HB674_RS06320	COG5484	DNA packaging
HB674_RS06325	COG1783	phage Terminase large subunit
HB674_RS06330	COG5518	Phage portal protein
HB674_RS06335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HB674_RS06340	COG4653	Phage capsid family
HB674_RS06390	COG5412	phage tail tape measure protein
HB674_RS06390	COG3953	SLT domain
HB674_RS06390	COG3953	SLT domain
HB674_RS06390	COG3953	SLT domain
HB674_RS06390	COG5412	phage tail tape measure protein
HB674_RS06390	COG5412	phage tail tape measure protein
HB674_RS06395	COG1652	LysM domain
HB674_RS06400	COG4193	domain, Protein
HB674_RS06410	COG3628	GPW Gp25 family protein
HB674_RS06415	COG3299	homolog of phage Mu protein gp47
HB674_RS06420	COG3778	Protein conserved in bacteria
HB674_RS06460	COG5632	N-Acetylmuramoyl-L-alanine amidase
HB674_RS06460	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS06475	COG0306	phosphate transporter
HB674_RS06480	COG1392	Phosphate transport regulator
HB674_RS06485	COG0531	amino acid
HB674_RS06490	COG0346	lactoylglutathione lyase activity
HB674_RS06495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HB674_RS06500	COG0463	Glycosyl transferase, family 2
HB674_RS06510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB674_RS06515	COG0477	Major facilitator Superfamily
HB674_RS06520	COG2362	D-Aminopeptidase
HB674_RS06525	COG0601	transmembrane transport
HB674_RS06530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB674_RS06535	COG0444	Belongs to the ABC transporter superfamily
HB674_RS06540	COG4166	transmembrane transport
HB674_RS06545	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB674_RS06550	COG4948	Mandelate Racemase Muconate Lactonizing
HB674_RS06555	COG0791	NLP P60 protein
HB674_RS06560	COG4608	Belongs to the ABC transporter superfamily
HB674_RS06565	COG2706	6-phosphogluconolactonase activity
HB674_RS06570	COG1834	amidinotransferase
HB674_RS06575	COG1607	acyl-coa hydrolase
HB674_RS06580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB674_RS06585	COG2076	Multidrug Resistance protein
HB674_RS06590	COG2076	Multidrug Resistance protein
HB674_RS06595	COG0788	formyltetrahydrofolate deformylase activity
HB674_RS06600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB674_RS06610	COG1764	response to oxidative stress
HB674_RS06615	COG1846	Transcriptional regulator
HB674_RS06620	COG1764	response to oxidative stress
HB674_RS06635	COG0457	Tetratricopeptide repeat
HB674_RS06635	COG0463	Glycosyl transferase, family 2
HB674_RS06655	COG1404	Belongs to the peptidase S8 family
HB674_RS06660	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS06665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HB674_RS06670	COG1122	ATPase activity
HB674_RS06675	COG4721	ABC-type cobalt transport system, permease component
HB674_RS06680	COG1388	LysM domain
HB674_RS06680	COG3858	chitin binding
HB674_RS06695	COG2239	Acts as a magnesium transporter
HB674_RS06700	COG0789	Transcriptional regulator
HB674_RS06715	COG1846	Transcriptional regulator
HB674_RS06720	COG0726	polysaccharide deacetylase
HB674_RS06725	COG3285	dna ligase
HB674_RS06725	COG1793	dna ligase
HB674_RS06730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB674_RS06740	COG0586	Pfam SNARE associated Golgi protein
HB674_RS06745	COG0861	Integral membrane protein TerC family
HB674_RS06750	COG1191	sigma factor activity
HB674_RS06775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB674_RS06780	COG2323	membrane
HB674_RS06790	COG3594	Acyltransferase
HB674_RS06795	COG5002	protein histidine kinase activity
HB674_RS06800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB674_RS06815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB674_RS06820	COG0436	Aminotransferase
HB674_RS06850	COG3852	Histidine kinase
HB674_RS06855	COG1846	Transcriptional regulator
HB674_RS06860	COG1360	Flagellar Motor Protein
HB674_RS06865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB674_RS06870	COG0542	response to heat
HB674_RS06875	COG3949	Membrane
HB674_RS06890	COG0720	synthase
HB674_RS06895	COG0602	queuosine metabolic process
HB674_RS06910	COG1733	regulation of RNA biosynthetic process
HB674_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS06930	COG4873	Protein conserved in bacteria
HB674_RS06940	COG3773	Cell wall hydrolase
HB674_RS06945	COG2244	polysaccharide biosynthetic process
HB674_RS06950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS06955	COG2217	Heavy metal translocating P-type atpase
HB674_RS06960	COG0006	proline dipeptidase activity
HB674_RS06965	COG1609	Transcriptional regulator
HB674_RS06970	COG3711	transcriptional antiterminator
HB674_RS06975	COG2190	(PTS) system
HB674_RS06975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS06975	COG1263	PTS System
HB674_RS06980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS06985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB674_RS06995	COG1533	DNA photolyase activity
HB674_RS07000	COG0840	transmembrane signaling receptor activity
HB674_RS07005	COG2084	Dehydrogenase
HB674_RS07010	COG2340	Cysteine-rich secretory protein family
HB674_RS07015	COG0768	penicillin binding
HB674_RS07020	COG4191	Histidine kinase
HB674_RS07025	COG0436	Aminotransferase
HB674_RS07035	COG0835	chemotaxis
HB674_RS07035	COG0784	Response regulator, receiver
HB674_RS07045	COG2814	Major facilitator Superfamily
HB674_RS07050	COG1376	ErfK ybiS ycfS ynhG family protein
HB674_RS07055	COG1408	metallophosphoesterase
HB674_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS07070	COG2200	EAL domain
HB674_RS07075	COG4703	Protein of unknown function (DUF1797)
HB674_RS07080	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HB674_RS07090	COG0517	IMP dehydrogenase activity
HB674_RS07095	COG0583	DNA-binding transcription factor activity
HB674_RS07100	COG0716	FMN binding
HB674_RS07110	COG0716	FMN binding
HB674_RS07130	COG0668	transmembrane transport
HB674_RS07135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS07155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB674_RS07160	COG0303	'Molybdopterin
HB674_RS07165	COG1763	Mo-molybdopterin cofactor biosynthetic process
HB674_RS07170	COG0314	molybdopterin synthase activity
HB674_RS07175	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HB674_RS07185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB674_RS07190	COG1136	(ABC) transporter
HB674_RS07195	COG0577	efflux transmembrane transporter activity
HB674_RS07200	COG1349	DNA-binding transcription factor activity
HB674_RS07205	COG1105	Belongs to the carbohydrate kinase PfkB family
HB674_RS07210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB674_RS07210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB674_RS07210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS07215	COG0681	Belongs to the peptidase S26 family
HB674_RS07225	COG0488	(ABC) transporter
HB674_RS07230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB674_RS07235	COG2309	aminopeptidase activity
HB674_RS07245	COG1077	Cell shape determining protein MreB Mrl
HB674_RS07250	COG2002	toxin-antitoxin pair type II binding
HB674_RS07255	COG3852	Histidine kinase
HB674_RS07260	COG2105	PFAM AIG2 family protein
HB674_RS07260	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HB674_RS07265	COG0569	domain protein
HB674_RS07275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HB674_RS07285	COG0561	phosphatase activity
HB674_RS07290	COG0242	peptide deformylase activity
HB674_RS07300	COG0497	DNA recombination
HB674_RS07305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB674_RS07305	COG2070	2-Nitropropane dioxygenase
HB674_RS07310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS07310	COG3321	synthase
HB674_RS07310	COG4221	oxidoreductase activity
HB674_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS07315	COG0300	oxidoreductase activity
HB674_RS07315	COG3321	synthase
HB674_RS07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS07315	COG4221	oxidoreductase activity
HB674_RS07320	COG3321	synthase
HB674_RS07320	COG4221	oxidoreductase activity
HB674_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS07320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS07325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS07325	COG0300	oxidoreductase activity
HB674_RS07325	COG4221	oxidoreductase activity
HB674_RS07325	COG3321	synthase
HB674_RS07330	COG4221	oxidoreductase activity
HB674_RS07330	COG3321	synthase
HB674_RS07330	COG0300	oxidoreductase activity
HB674_RS07330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS07335	COG4221	oxidoreductase activity
HB674_RS07335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS07335	COG0300	oxidoreductase activity
HB674_RS07335	COG3321	synthase
HB674_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS07340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS07340	COG3321	synthase
HB674_RS07340	COG4221	oxidoreductase activity
HB674_RS07345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB674_RS07350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB674_RS07355	COG0022	dehydrogenase e1 component
HB674_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB674_RS07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB674_RS07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS07385	COG1982	Orn Lys Arg decarboxylase major
HB674_RS07405	COG0483	inositol monophosphate 1-phosphatase activity
HB674_RS07415	COG3227	Zinc metalloprotease (Elastase)
HB674_RS07450	COG4896	Protein conserved in bacteria
HB674_RS07460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HB674_RS07465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB674_RS07470	COG2066	Belongs to the glutaminase family
HB674_RS07480	COG0772	Belongs to the SEDS family
HB674_RS07485	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HB674_RS07500	COG2010	Cytochrome c
HB674_RS07500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB674_RS07505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB674_RS07510	COG1845	cytochrome c oxidase, subunit III
HB674_RS07515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB674_RS07520	COG3336	cytochrome c oxidase
HB674_RS07530	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HB674_RS07535	COG2340	Cysteine-rich secretory protein family
HB674_RS07550	COG3679	Belongs to the UPF0342 family
HB674_RS07560	COG0742	ribosomal rna small subunit methyltransferase
HB674_RS07570	COG3314	Sporulation integral membrane protein YlbJ
HB674_RS07575	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB674_RS07580	COG3480	Lon protease (S16) C-terminal proteolytic domain
HB674_RS07590	COG1399	metal-binding, possibly nucleic acid-binding protein
HB674_RS07610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB674_RS07630	COG4839	cell division protein FtsL
HB674_RS07640	COG0768	penicillin binding
HB674_RS07660	COG0772	Belongs to the SEDS family
HB674_RS07675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB674_RS07680	COG0849	cell division
HB674_RS07685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB674_RS07690	COG4412	M6 family metalloprotease domain protein
HB674_RS07690	COG1404	Belongs to the peptidase S8 family
HB674_RS07700	COG1191	sigma factor activity
HB674_RS07705	COG1191	sigma factor activity
HB674_RS07710	COG1119	ATPase activity
HB674_RS07715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB674_RS07720	COG1873	PFAM PRC-barrel domain
HB674_RS07730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HB674_RS07740	COG0762	integral membrane protein
HB674_RS07745	COG2302	S4 RNA-binding domain
HB674_RS07750	COG3599	regulation of cell shape
HB674_RS07755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB674_RS07760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB674_RS07770	COG0564	pseudouridine synthase activity
HB674_RS07780	COG2233	PERMEase
HB674_RS07790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB674_RS07795	COG0505	Belongs to the CarA family
HB674_RS07800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB674_RS07815	COG0284	orotidine-5'-phosphate decarboxylase activity
HB674_RS07820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB674_RS07830	COG0306	phosphate transporter
HB674_RS07845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB674_RS07850	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HB674_RS07855	COG1648	precorrin-2 dehydrogenase activity
HB674_RS07865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB674_RS07870	COG1561	YicC-like family, N-terminal region
HB674_RS07880	COG0194	GDP metabolic process
HB674_RS07890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB674_RS07895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB674_RS07900	COG0242	peptide deformylase activity
HB674_RS07910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB674_RS07910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HB674_RS07920	COG0631	protein serine/threonine phosphatase activity
HB674_RS07925	COG2815	serine threonine protein kinase
HB674_RS07925	COG0515	serine threonine protein kinase
HB674_RS07935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB674_RS07940	COG1564	THIamine pyrophosphokinase
HB674_RS07955	COG1302	Protein conserved in bacteria
HB674_RS07960	COG1461	Dihydroxyacetone kinase
HB674_RS07965	COG1760	l-serine dehydratase
HB674_RS07970	COG1760	l-serine dehydratase
HB674_RS07975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB674_RS07990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB674_RS07995	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS08010	COG1196	nuclear chromosome segregation
HB674_RS08015	COG0552	protein localization to endoplasmic reticulum
HB674_RS08030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB674_RS08040	COG1837	Belongs to the UPF0109 family
HB674_RS08065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HB674_RS08080	COG2257	FlhB HrpN YscU SpaS Family
HB674_RS08090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HB674_RS08095	COG0758	DNA mediated transformation
HB674_RS08100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB674_RS08110	COG4974	Belongs to the 'phage' integrase family
HB674_RS08130	COG1815	bacterial-type flagellum-dependent cell motility
HB674_RS08135	COG1558	bacterial-type flagellum-dependent cell motility
HB674_RS08140	COG1677	Flagellar hook-basal body complex protein FliE
HB674_RS08145	COG1766	The M ring may be actively involved in energy transduction
HB674_RS08150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB674_RS08155	COG1317	bacterial-type flagellum organization
HB674_RS08160	COG1157	protein secretion by the type III secretion system
HB674_RS08165	COG2882	bacterial-type flagellum organization
HB674_RS08170	COG3334	PFAM MgtE intracellular
HB674_RS08175	COG3144	bacterial-type flagellum assembly
HB674_RS08180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB674_RS08185	COG4786	Flagellar basal body rod
HB674_RS08190	COG1582	Flagellar protein (FlbD)
HB674_RS08195	COG1580	Controls the rotational direction of flagella during chemotaxis
HB674_RS08200	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB674_RS08205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB674_RS08205	COG1776	CheC inhibitor of MCP methylation
HB674_RS08210	COG2201	protein-glutamate methylesterase activity
HB674_RS08215	COG3190	flagellar
HB674_RS08220	COG1338	Plays a role in the flagellum-specific transport system
HB674_RS08225	COG1987	bacterial-type flagellum assembly
HB674_RS08230	COG1684	flagellar biosynthetic protein fliR
HB674_RS08235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB674_RS08240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB674_RS08245	COG1419	protein localization to endoplasmic reticulum
HB674_RS08250	COG0455	bacterial-type flagellum organization
HB674_RS08255	COG2201	protein-glutamate methylesterase activity
HB674_RS08260	COG2198	Histidine kinase
HB674_RS08260	COG0643	Histidine kinase
HB674_RS08265	COG0835	chemotaxis
HB674_RS08270	COG1776	CheC inhibitor of MCP methylation
HB674_RS08280	COG1191	sigma factor activity
HB674_RS08310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB674_RS08315	COG4589	Belongs to the CDS family
HB674_RS08325	COG0750	zinc metalloprotease
HB674_RS08335	COG2176	DNA-directed DNA polymerase activity
HB674_RS08345	COG0195	Participates in both transcription termination and antitermination
HB674_RS08350	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HB674_RS08355	COG1358	cellular component organization or biogenesis
HB674_RS08365	COG1550	Protein conserved in bacteria
HB674_RS08380	COG0196	riboflavin kinase activity
HB674_RS08395	COG0726	polysaccharide deacetylase
HB674_RS08400	COG0612	Peptidase, M16
HB674_RS08405	COG1873	PFAM PRC-barrel domain
HB674_RS08410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB674_RS08415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB674_RS08420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB674_RS08425	COG0527	aspartate kinase activity
HB674_RS08435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HB674_RS08440	COG0740	serine-type endopeptidase activity
HB674_RS08450	COG1674	ftsk spoiiie
HB674_RS08450	COG4980	gas vesicle protein
HB674_RS08455	COG2188	Transcriptional regulator
HB674_RS08460	COG2814	Major facilitator Superfamily
HB674_RS08465	COG1846	Transcriptional regulator
HB674_RS08470	COG1033	growth of symbiont in host cell
HB674_RS08470	COG2409	Drug exporters of the RND superfamily
HB674_RS08475	COG0612	Peptidase, M16
HB674_RS08480	COG0612	Peptidase, M16
HB674_RS08485	COG0300	oxidoreductase activity
HB674_RS08500	COG1426	Protein conserved in bacteria
HB674_RS08505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB674_RS08520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB674_RS08530	COG1692	metallophosphoesterase
HB674_RS08535	COG2359	stage V sporulation protein S
HB674_RS08555	COG4550	Control of competence regulator ComK, YlbF/YmcA
HB674_RS08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS08605	COG3425	synthase
HB674_RS08610	COG1024	Enoyl-CoA hydratase
HB674_RS08615	COG1024	Enoyl-CoA hydratase
HB674_RS08620	COG0300	oxidoreductase activity
HB674_RS08620	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS08620	COG3321	synthase
HB674_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS08620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS08625	COG4221	oxidoreductase activity
HB674_RS08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS08625	COG3321	synthase
HB674_RS08625	COG0300	oxidoreductase activity
HB674_RS08630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS08630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS08630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS08630	COG3321	synthase
HB674_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS08630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS08630	COG3321	synthase
HB674_RS08630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS08630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS08635	COG4221	oxidoreductase activity
HB674_RS08635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS08635	COG3321	synthase
HB674_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS08640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB674_RS08640	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HB674_RS08640	COG3321	synthase
HB674_RS08640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS08645	COG2124	cytochrome p450
HB674_RS08650	COG3209	COG3209 Rhs family protein
HB674_RS08655	COG3619	membrane
HB674_RS08665	COG1404	Belongs to the peptidase S8 family
HB674_RS08675	COG4195	phage-related replication protein
HB674_RS08680	COG1764	response to oxidative stress
HB674_RS08690	COG2076	Multidrug Resistance protein
HB674_RS08730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB674_RS08735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB674_RS08740	COG4112	unkown
HB674_RS08745	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS08755	COG0464	growth
HB674_RS08760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB674_RS08765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HB674_RS08770	COG0789	Transcriptional regulator
HB674_RS08775	COG0174	glutamine synthetase
HB674_RS08815	COG2211	Major facilitator Superfamily
HB674_RS08820	COG3507	Belongs to the glycosyl hydrolase 43 family
HB674_RS08835	COG1070	Carbohydrate kinase
HB674_RS08840	COG0574	Belongs to the PEP-utilizing enzyme family
HB674_RS08840	COG3848	Pyruvate phosphate dikinase
HB674_RS08865	COG1064	alcohol dehydrogenase
HB674_RS08870	COG4451	ribulose bisphosphate carboxylase, small
HB674_RS08870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB674_RS08915	COG3397	chitin binding
HB674_RS08935	COG5434	Belongs to the glycosyl hydrolase 28 family
HB674_RS08940	COG0756	dUTP diphosphatase activity
HB674_RS08945	COG4195	phage-related replication protein
HB674_RS08980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB674_RS08990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB674_RS09010	COG0785	Cytochrome C biogenesis protein
HB674_RS09015	COG2201	protein-glutamate methylesterase activity
HB674_RS09020	COG4846	Membrane protein involved in cytochrome C biogenesis
HB674_RS09030	COG0071	Belongs to the small heat shock protein (HSP20) family
HB674_RS09045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB674_RS09050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS09070	COG0824	Thioesterase
HB674_RS09080	COG4841	protein insertion into membrane
HB674_RS09090	COG1832	CoA-binding protein
HB674_RS09095	COG0187	DNA topoisomerase II activity
HB674_RS09100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB674_RS09110	COG1115	amino acid carrier protein
HB674_RS09120	COG1063	alcohol dehydrogenase
HB674_RS09125	COG0800	Aldolase
HB674_RS09130	COG1312	Catalyzes the dehydration of D-mannonate
HB674_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS09140	COG1609	Transcriptional regulator
HB674_RS09145	COG2271	Major facilitator Superfamily
HB674_RS09190	COG2205	protein histidine kinase activity
HB674_RS09195	COG0745	RESPONSE REGULATOR receiver
HB674_RS09205	COG3507	Belongs to the glycosyl hydrolase 43 family
HB674_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS09235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB674_RS09240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB674_RS09245	COG2610	gluconate transmembrane transporter activity
HB674_RS09250	COG2124	cytochrome p450
HB674_RS09270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB674_RS09280	COG2246	polysaccharide biosynthetic process
HB674_RS09290	COG0586	Pfam SNARE associated Golgi protein
HB674_RS09295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB674_RS09300	COG1024	Enoyl-CoA hydratase
HB674_RS09305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB674_RS09310	COG0511	ligase activity, forming carbon-carbon bonds
HB674_RS09315	COG0439	Biotin carboxylase
HB674_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS09325	COG1960	acyl-CoA dehydrogenase activity
HB674_RS09330	COG1649	PFAM Uncharacterised BCR, COG1649
HB674_RS09340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS09340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HB674_RS09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS09365	COG2027	D-alanyl-D-alanine carboxypeptidase
HB674_RS09370	COG2017	converts alpha-aldose to the beta-anomer
HB674_RS09375	COG0534	Mate efflux family protein
HB674_RS09390	COG0582	viral genome integration into host DNA
HB674_RS09395	COG0166	Belongs to the GPI family
HB674_RS09400	COG0405	Gamma-glutamyltransferase
HB674_RS09405	COG2814	Major facilitator Superfamily
HB674_RS09410	COG0640	Transcriptional regulator
HB674_RS09415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB674_RS09425	COG0604	alcohol dehydrogenase
HB674_RS09430	COG0493	'glutamate synthase
HB674_RS09435	COG0067	glutamate synthase
HB674_RS09435	COG0070	glutamate synthase
HB674_RS09435	COG0069	glutamate synthase activity
HB674_RS09440	COG0583	DNA-binding transcription factor activity
HB674_RS09445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB674_RS09460	COG0300	oxidoreductase activity
HB674_RS09465	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HB674_RS09475	COG2814	Major facilitator Superfamily
HB674_RS09480	COG1070	Carbohydrate kinase
HB674_RS09485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB674_RS09490	COG0243	molybdopterin cofactor binding
HB674_RS09520	COG5444	nuclease activity
HB674_RS09525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB674_RS09530	COG2207	Transcriptional regulator
HB674_RS09530	COG0662	Cupin 2, conserved barrel domain protein
HB674_RS09535	COG1309	transcriptional regulator
HB674_RS09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS09550	COG0640	Transcriptional regulator
HB674_RS09555	COG0741	lytic transglycosylase activity
HB674_RS09560	COG2322	membrane
HB674_RS09575	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB674_RS09585	COG3584	3D domain protein
HB674_RS09585	COG1388	LysM domain
HB674_RS09590	COG0514	ATP-dependent DNA helicase (RecQ)
HB674_RS09600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB674_RS09605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB674_RS09620	COG0071	Belongs to the small heat shock protein (HSP20) family
HB674_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS09655	COG1657	PFAM Prenyltransferase squalene oxidase
HB674_RS09660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB674_RS09665	COG0733	neurotransmitter:sodium symporter activity
HB674_RS09670	COG0385	Bile acid
HB674_RS09675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS09680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB674_RS09690	COG4548	von Willebrand factor, type A
HB674_RS09695	COG0714	Associated with various cellular activities
HB674_RS09700	COG2032	superoxide dismutase activity
HB674_RS09705	COG1388	LysM domain
HB674_RS09705	COG0791	NLP P60 protein
HB674_RS09710	COG1819	glycosyl
HB674_RS09715	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HB674_RS09720	COG0534	Mate efflux family protein
HB674_RS09725	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS09730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB674_RS09735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB674_RS09745	COG2962	Rard protein
HB674_RS09760	COG1942	4-Oxalocrotonate Tautomerase
HB674_RS09770	COG1733	regulation of RNA biosynthetic process
HB674_RS09775	COG0778	Nitroreductase
HB674_RS09780	COG0400	carboxylic ester hydrolase activity
HB674_RS09785	COG0346	lactoylglutathione lyase activity
HB674_RS09795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB674_RS09805	COG2723	6-phospho-beta-galactosidase activity
HB674_RS09810	COG2188	Transcriptional regulator
HB674_RS09815	COG0793	Belongs to the peptidase S41A family
HB674_RS09815	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS09820	COG2226	methyltransferase
HB674_RS09830	COG1876	peptidase activity
HB674_RS09850	COG0671	phosphoesterase, PA-phosphatase related
HB674_RS09880	COG1509	lysine 2,3-aminomutase activity
HB674_RS09885	COG0456	acetyltransferase
HB674_RS09890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB674_RS09895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB674_RS09900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB674_RS09905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB674_RS09910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HB674_RS09920	COG0456	acetyltransferase
HB674_RS09925	COG0463	Glycosyl transferase, family 2
HB674_RS09940	COG4641	Protein conserved in bacteria
HB674_RS09950	COG1086	Polysaccharide biosynthesis protein
HB674_RS09985	COG0457	Tetratricopeptide repeat
HB674_RS09995	COG3391	amine dehydrogenase activity
HB674_RS10015	COG5444	nuclease activity
HB674_RS10020	COG4282	regulation of fungal-type cell wall biogenesis
HB674_RS10025	COG1525	nuclease
HB674_RS10030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB674_RS10050	COG1846	Transcriptional regulator
HB674_RS10055	COG4698	Protein conserved in bacteria
HB674_RS10060	COG2755	lipolytic protein G-D-S-L family
HB674_RS10065	COG1999	signal sequence binding
HB674_RS10075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB674_RS10080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HB674_RS10085	COG1272	protein, Hemolysin III
HB674_RS10090	COG0204	Acyl-transferase
HB674_RS10095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB674_RS10110	COG2521	methyltransferase
HB674_RS10110	COG2136	Putative SAM-dependent methyltransferase
HB674_RS10125	COG1413	lyase activity
HB674_RS10130	COG1418	mRNA catabolic process
HB674_RS10135	COG0386	Belongs to the glutathione peroxidase family
HB674_RS10145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HB674_RS10155	COG1278	Cold shock
HB674_RS10175	COG0328	RNA-DNA hybrid ribonuclease activity
HB674_RS10180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HB674_RS10185	COG0328	RNA-DNA hybrid ribonuclease activity
HB674_RS10195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB674_RS10210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HB674_RS10220	COG1755	Isoprenylcysteine carboxyl methyltransferase
HB674_RS10225	COG3424	synthase
HB674_RS10245	COG1335	isochorismatase
HB674_RS10255	COG2233	PERMEase
HB674_RS10265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HB674_RS10270	COG1199	ATP-dependent helicase activity
HB674_RS10285	COG0116	Belongs to the methyltransferase superfamily
HB674_RS10315	COG3359	exonuclease
HB674_RS10320	COG1111	helicase
HB674_RS10320	COG1205	dead DEAH box helicase
HB674_RS10325	COG2190	(PTS) system
HB674_RS10330	COG0071	Belongs to the small heat shock protein (HSP20) family
HB674_RS10370	COG4499	WXG100 protein secretion system (Wss), protein YukC
HB674_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB674_RS10380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB674_RS10385	COG3935	DnaD domain protein
HB674_RS10395	COG0436	Aminotransferase
HB674_RS10400	COG5353	protein conserved in bacteria
HB674_RS10410	COG1199	ATP-dependent helicase activity
HB674_RS10410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB674_RS10440	COG0438	transferase activity, transferring glycosyl groups
HB674_RS10445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB674_RS10460	COG1694	Mazg nucleotide pyrophosphohydrolase
HB674_RS10465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS10480	COG4347	Protein of unknown function (DUF1405)
HB674_RS10485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB674_RS10485	COG2010	Cytochrome c
HB674_RS10490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB674_RS10495	COG0723	plastoquinol--plastocyanin reductase activity
HB674_RS10510	COG0457	Tetratricopeptide repeat
HB674_RS10520	COG0287	Prephenate dehydrogenase
HB674_RS10555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB674_RS10560	COG4401	Chorismate mutase type I
HB674_RS10575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HB674_RS10580	COG0105	UTP biosynthetic process
HB674_RS10585	COG0142	geranyltranstransferase activity
HB674_RS10595	COG0142	geranyltranstransferase activity
HB674_RS10610	COG0776	regulation of translation
HB674_RS10615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HB674_RS10655	COG0539	negative regulation of cytoplasmic translation
HB674_RS10670	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HB674_RS10675	COG2959	enzyme of heme biosynthesis
HB674_RS10680	COG3773	Cell wall hydrolase
HB674_RS10680	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS10685	COG2339	peptidase activity
HB674_RS10690	COG0492	ferredoxin-NADP+ reductase activity
HB674_RS10695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB674_RS10700	COG4862	establishment of competence for transformation
HB674_RS10705	COG1408	metallophosphoesterase
HB674_RS10715	COG1388	LysM domain
HB674_RS10720	COG1266	CAAX protease self-immunity
HB674_RS10725	COG0514	ATP-dependent DNA helicase (RecQ)
HB674_RS10730	COG4955	Helix-turn-helix domain
HB674_RS10735	COG1141	Ferredoxin
HB674_RS10740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HB674_RS10745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB674_RS10755	COG1595	DNA-templated transcription, initiation
HB674_RS10760	COG5002	protein histidine kinase activity
HB674_RS10765	COG0745	RESPONSE REGULATOR receiver
HB674_RS10770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB674_RS10775	COG1333	cytochrome c biogenesis protein
HB674_RS10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS10785	COG1187	pseudouridine synthase activity
HB674_RS10790	COG0700	Nucleoside recognition
HB674_RS10795	COG2715	membrane protein required for spore maturation
HB674_RS10800	COG1686	Belongs to the peptidase S11 family
HB674_RS10825	COG1547	Domain of unknown function (DUF309)
HB674_RS10830	COG0456	acetyltransferase
HB674_RS10845	COG0307	riboflavin synthase, alpha
HB674_RS10850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB674_RS10850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB674_RS10860	COG0681	Belongs to the peptidase S26 family
HB674_RS10870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB674_RS10875	COG4086	secreted protein
HB674_RS10880	COG0019	diaminopimelate decarboxylase activity
HB674_RS10885	COG0697	spore germination
HB674_RS10900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB674_RS10920	COG1191	sigma factor activity
HB674_RS10930	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS10935	COG1686	Belongs to the peptidase S11 family
HB674_RS10940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HB674_RS10945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HB674_RS10950	COG4974	Belongs to the 'phage' integrase family
HB674_RS10960	COG0735	belongs to the Fur family
HB674_RS10965	COG1300	Membrane
HB674_RS10980	COG0281	malic enzyme
HB674_RS10985	COG1757	Na H antiporter
HB674_RS10990	COG1027	Aspartate ammonia-lyase
HB674_RS10995	COG0252	asparaginase activity
HB674_RS11000	COG1396	sequence-specific DNA binding
HB674_RS11005	COG1379	DNA repair
HB674_RS11010	COG0494	nUDIX hydrolase
HB674_RS11020	COG0667	Aldo Keto reductase
HB674_RS11030	COG1073	alpha beta
HB674_RS11040	COG4918	Iron-sulphur cluster biosynthesis
HB674_RS11045	COG0456	acetyltransferase
HB674_RS11045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB674_RS11050	COG2329	Antibiotic biosynthesis monooxygenase
HB674_RS11055	COG0456	acetyltransferase
HB674_RS11060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB674_RS11075	COG0628	permease
HB674_RS11085	COG0346	lactoylglutathione lyase activity
HB674_RS11095	COG3048	D-serine ammonia-lyase activity
HB674_RS11100	COG0300	oxidoreductase activity
HB674_RS11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS11110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB674_RS11115	COG1024	Enoyl-CoA hydratase
HB674_RS11120	COG3425	synthase
HB674_RS11125	COG2124	cytochrome p450
HB674_RS11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS11130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS11130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11130	COG3321	synthase
HB674_RS11135	COG3321	synthase
HB674_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS11135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS11140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11140	COG3321	synthase
HB674_RS11140	COG0300	oxidoreductase activity
HB674_RS11145	COG0300	oxidoreductase activity
HB674_RS11145	COG3321	synthase
HB674_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11145	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS11150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS11150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS11150	COG3321	synthase
HB674_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11155	COG3321	synthase
HB674_RS11155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS11155	COG0300	oxidoreductase activity
HB674_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS11160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS11160	COG3321	synthase
HB674_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB674_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS11170	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS11185	COG2070	2-Nitropropane dioxygenase
HB674_RS11185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB674_RS11190	COG0250	Participates in transcription elongation, termination and antitermination
HB674_RS11210	COG0596	Alpha beta hydrolase
HB674_RS11225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HB674_RS11230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HB674_RS11245	COG0706	membrane insertase activity
HB674_RS11250	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB674_RS11255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB674_RS11260	COG0346	lactoylglutathione lyase activity
HB674_RS11275	COG4129	membrane
HB674_RS11285	COG0765	amino acid transport
HB674_RS11290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB674_RS11300	COG1597	lipid kinase activity
HB674_RS11305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB674_RS11310	COG0022	dehydrogenase e1 component
HB674_RS11315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB674_RS11320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB674_RS11325	COG3426	butyrate kinase activity
HB674_RS11330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB674_RS11335	COG0280	phosphate acetyltransferase
HB674_RS11340	COG3829	transcription factor binding
HB674_RS11340	COG3290	protein histidine kinase activity
HB674_RS11350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB674_RS11355	COG2079	MmgE PrpD family protein
HB674_RS11360	COG0372	Belongs to the citrate synthase family
HB674_RS11365	COG1960	acyl-CoA dehydrogenase activity
HB674_RS11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB674_RS11375	COG0183	Belongs to the thiolase family
HB674_RS11380	COG0584	glycerophosphoryl diester phosphodiesterase
HB674_RS11385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS11410	COG1902	pentaerythritol trinitrate reductase activity
HB674_RS11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB674_RS11430	COG0745	RESPONSE REGULATOR receiver
HB674_RS11435	COG0750	zinc metalloprotease
HB674_RS11440	COG0497	DNA recombination
HB674_RS11450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HB674_RS11460	COG0142	geranyltranstransferase activity
HB674_RS11470	COG1570	exodeoxyribonuclease VII activity
HB674_RS11485	COG1302	Protein conserved in bacteria
HB674_RS11490	COG0439	Biotin carboxylase
HB674_RS11495	COG0511	ligase activity, forming carbon-carbon bonds
HB674_RS11535	COG3854	ATPases associated with a variety of cellular activities
HB674_RS11550	COG0006	proline dipeptidase activity
HB674_RS11560	COG3872	metal-dependent enzyme
HB674_RS11570	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB674_RS11585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB674_RS11605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HB674_RS11620	COG1396	sequence-specific DNA binding
HB674_RS11630	COG0681	Belongs to the peptidase S26 family
HB674_RS11655	COG4940	Competence protein ComGF
HB674_RS11665	COG4970	Tfp pilus assembly protein FimT
HB674_RS11670	COG4537	Required for transformation and DNA binding
HB674_RS11675	COG1459	type II secretion system
HB674_RS11680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB674_RS11685	COG0598	Magnesium transport protein CorA
HB674_RS11690	COG1253	flavin adenine dinucleotide binding
HB674_RS11695	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS11705	COG1393	Belongs to the ArsC family
HB674_RS11715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS11725	COG0011	TIGRFAM Protein of
HB674_RS11735	COG2866	Carboxypeptidase
HB674_RS11740	COG1940	carbohydrate kinase activity
HB674_RS11745	COG4483	Protein conserved in bacteria
HB674_RS11750	COG1757	Na H antiporter
HB674_RS11760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB674_RS11775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB674_RS11780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB674_RS11785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB674_RS11790	COG0581	inorganic phosphate transmembrane transporter activity
HB674_RS11795	COG0573	inorganic phosphate transmembrane transporter activity
HB674_RS11800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB674_RS11810	COG0477	Major facilitator Superfamily
HB674_RS11815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB674_RS11820	COG2839	Protein conserved in bacteria
HB674_RS11825	COG5521	maltodextrose utilization protein MalA
HB674_RS11830	COG1388	LysM domain
HB674_RS11840	COG4709	membrane
HB674_RS11845	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HB674_RS11850	COG0735	belongs to the Fur family
HB674_RS11855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS11870	COG0513	Belongs to the DEAD box helicase family
HB674_RS11885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB674_RS11890	COG2384	SAM-dependent methyltransferase
HB674_RS11895	COG2010	Cytochrome c
HB674_RS11900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB674_RS11905	COG0358	DNA primase activity
HB674_RS11920	COG0517	IMP dehydrogenase activity
HB674_RS11925	COG0751	glycine-tRNA ligase activity
HB674_RS11945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB674_RS11950	COG0295	cytidine deaminase activity
HB674_RS11955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB674_RS11965	COG1480	7TM receptor with intracellular HD hydrolase
HB674_RS11970	COG1702	phosphate starvation-inducible protein PhoH
HB674_RS11975	COG0561	phosphatase activity
HB674_RS11990	COG4864	UPF0365 protein
HB674_RS11995	COG1030	water channel activity
HB674_RS12000	COG1610	YqeY-like protein
HB674_RS12010	COG1283	sodium-dependent phosphate transmembrane transporter activity
HB674_RS12015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB674_RS12020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB674_RS12050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB674_RS12065	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS12080	COG1466	dna polymerase III delta subunit
HB674_RS12095	COG2333	competence protein COMEC
HB674_RS12095	COG0658	competence protein
HB674_RS12100	COG2131	deaminase
HB674_RS12105	COG1555	photosystem II stabilization
HB674_RS12105	COG1596	polysaccharide export
HB674_RS12110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB674_RS12115	COG2226	methyltransferase
HB674_RS12120	COG0799	negative regulation of ribosome biogenesis
HB674_RS12125	COG1713	HD superfamily hydrolase involved in NAD metabolism
HB674_RS12135	COG1534	Rna-binding protein
HB674_RS12140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB674_RS12145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HB674_RS12150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HB674_RS12160	COG2755	lipolytic protein G-D-S-L family
HB674_RS12170	COG0398	Pfam SNARE associated Golgi protein
HB674_RS12195	COG1794	racemase activity, acting on amino acids and derivatives
HB674_RS12210	COG1733	regulation of RNA biosynthetic process
HB674_RS12215	COG0656	L-ascorbic acid biosynthetic process
HB674_RS12245	COG3677	Transposase
HB674_RS12285	COG5002	protein histidine kinase activity
HB674_RS12285	COG0642	Histidine kinase
HB674_RS12290	COG0745	RESPONSE REGULATOR receiver
HB674_RS12295	COG2311	Membrane
HB674_RS12305	COG0454	-acetyltransferase
HB674_RS12310	COG0563	adenylate kinase activity
HB674_RS12320	COG2814	Major facilitator Superfamily
HB674_RS12330	COG0456	acetyltransferase
HB674_RS12335	COG2318	DinB family
HB674_RS12345	COG0561	phosphatase activity
HB674_RS12350	COG0561	phosphatase activity
HB674_RS12360	COG1482	cell wall glycoprotein biosynthetic process
HB674_RS12365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS12365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB674_RS12365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB674_RS12370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS12370	COG3711	transcriptional antiterminator
HB674_RS12380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB674_RS12385	COG0583	DNA-binding transcription factor activity
HB674_RS12390	COG2814	Major facilitator Superfamily
HB674_RS12395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB674_RS12395	COG2124	cytochrome p450
HB674_RS12400	COG1309	transcriptional regulator
HB674_RS12405	COG2226	methyltransferase
HB674_RS12420	COG2116	formate transmembrane transporter activity
HB674_RS12425	COG5609	conserved protein (DUF2294)
HB674_RS12430	COG3383	formate dehydrogenase (NAD+) activity
HB674_RS12435	COG2427	Protein of unknown function (DUF1641)
HB674_RS12445	COG0626	cystathionine gamma-synthase activity
HB674_RS12450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB674_RS12475	COG0768	penicillin binding
HB674_RS12500	COG4122	O-methyltransferase activity
HB674_RS12505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB674_RS12530	COG0628	permease
HB674_RS12535	COG1126	abc transporter atp-binding protein
HB674_RS12540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB674_RS12545	COG0765	amino acid transport
HB674_RS12550	COG0765	amino acid transport
HB674_RS12565	COG3881	PFAM PRC-barrel domain
HB674_RS12570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB674_RS12575	COG0457	Tetratricopeptide repeat
HB674_RS12585	COG1104	cysteine desulfurase activity
HB674_RS12590	COG1959	2 iron, 2 sulfur cluster binding
HB674_RS12595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB674_RS12600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB674_RS12625	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS12625	COG4991	sh3 domain protein
HB674_RS12625	COG3103	Sh3 type 3 domain protein
HB674_RS12635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB674_RS12645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB674_RS12645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HB674_RS12650	COG5416	Lipopolysaccharide assembly protein A domain
HB674_RS12655	COG0490	domain, Protein
HB674_RS12660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB674_RS12660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB674_RS12670	COG2244	polysaccharide biosynthetic process
HB674_RS12675	COG2323	membrane
HB674_RS12685	COG1862	Preprotein translocase
HB674_RS12725	COG1388	LysM domain
HB674_RS12735	COG0157	Belongs to the NadC ModD family
HB674_RS12740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB674_RS12745	COG1104	cysteine desulfurase activity
HB674_RS12750	COG1827	regulation of RNA biosynthetic process
HB674_RS12755	COG0077	Prephenate dehydratase
HB674_RS12770	COG3290	protein histidine kinase activity
HB674_RS12775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HB674_RS12780	COG2868	ribosomal protein
HB674_RS12790	COG1994	Peptidase M50
HB674_RS12795	COG0739	heme binding
HB674_RS12800	COG2894	cell division
HB674_RS12805	COG0850	regulation of cytokinetic process
HB674_RS12810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB674_RS12820	COG1077	Cell shape determining protein MreB Mrl
HB674_RS12840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HB674_RS12845	COG0285	dihydrofolate synthase activity
HB674_RS12850	COG0525	valine-tRNA ligase activity
HB674_RS12860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB674_RS12865	COG1388	LysM domain
HB674_RS12875	COG0113	porphobilinogen synthase activity
HB674_RS12880	COG1587	Uroporphyrinogen-III synthase
HB674_RS12890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB674_RS12910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB674_RS12915	COG0470	DNA polymerase III
HB674_RS12915	COG1067	ATP-dependent peptidase activity
HB674_RS12930	COG1477	protein flavinylation
HB674_RS12930	COG0457	Tetratricopeptide repeat
HB674_RS12945	COG0473	3-isopropylmalate dehydrogenase activity
HB674_RS12960	COG0440	acetolactate synthase activity
HB674_RS12965	COG0028	Belongs to the TPP enzyme family
HB674_RS12990	COG0622	Phosphoesterase
HB674_RS12995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB674_RS13005	COG5401	PFAM Sporulation and spore germination
HB674_RS13015	COG1846	Transcriptional regulator
HB674_RS13020	COG2197	response regulator
HB674_RS13025	COG0824	Thioesterase
HB674_RS13030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB674_RS13035	COG1053	succinate dehydrogenase
HB674_RS13040	COG2009	succinate dehydrogenase
HB674_RS13045	COG1719	4-vinyl reductase, 4VR
HB674_RS13050	COG0527	aspartate kinase activity
HB674_RS13060	COG3118	belongs to the thioredoxin family
HB674_RS13065	COG3534	alpha-L-arabinofuranosidase
HB674_RS13070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HB674_RS13075	COG2086	electron transfer activity
HB674_RS13080	COG1024	Enoyl-CoA hydratase
HB674_RS13085	COG1309	transcriptional regulator
HB674_RS13090	COG0318	PFAM AMP-dependent synthetase and ligase
HB674_RS13100	COG3766	membrane
HB674_RS13110	COG1796	DNA polymerase
HB674_RS13110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HB674_RS13115	COG1286	toxin biosynthetic process
HB674_RS13130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB674_RS13130	COG0072	phenylalanine-tRNA ligase activity
HB674_RS13135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HB674_RS13140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB674_RS13150	COG3835	regulator
HB674_RS13155	COG0277	FAD linked oxidase domain protein
HB674_RS13160	COG0247	lactate metabolic process
HB674_RS13165	COG1966	Carbon starvation protein
HB674_RS13170	COG3534	alpha-L-arabinofuranosidase
HB674_RS13175	COG0395	ABC-type sugar transport system, permease component
HB674_RS13180	COG1175	transmembrane transport
HB674_RS13185	COG1653	transport
HB674_RS13195	COG0647	UMP catabolic process
HB674_RS13200	COG0235	Class ii aldolase
HB674_RS13205	COG1069	ribulokinase activity
HB674_RS13210	COG2160	L-arabinose isomerase activity
HB674_RS13215	COG3507	Belongs to the glycosyl hydrolase 43 family
HB674_RS13220	COG1363	Peptidase, m42
HB674_RS13230	COG3326	Membrane
HB674_RS13245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HB674_RS13250	COG1346	cytolysis
HB674_RS13255	COG1380	Effector of murein hydrolase LrgA
HB674_RS13260	COG3279	Response regulator of the LytR AlgR family
HB674_RS13265	COG3275	phosphorelay sensor kinase activity
HB674_RS13270	COG1011	Hydrolase
HB674_RS13285	COG0398	Pfam SNARE associated Golgi protein
HB674_RS13290	COG1484	DNA-dependent DNA replication
HB674_RS13295	COG3611	Membrane attachment protein
HB674_RS13310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB674_RS13315	COG1733	regulation of RNA biosynthetic process
HB674_RS13320	COG2814	Major facilitator Superfamily
HB674_RS13325	COG0656	L-ascorbic acid biosynthetic process
HB674_RS13330	COG0237	dephospho-CoA kinase activity
HB674_RS13335	COG1971	Probably functions as a manganese efflux pump
HB674_RS13340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB674_RS13345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB674_RS13345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB674_RS13350	COG5002	protein histidine kinase activity
HB674_RS13355	COG0745	RESPONSE REGULATOR receiver
HB674_RS13365	COG0538	isocitrate dehydrogenase activity
HB674_RS13370	COG0372	Belongs to the citrate synthase family
HB674_RS13400	COG0628	permease
HB674_RS13405	COG3030	protein affecting phage T7 exclusion by the F plasmid
HB674_RS13410	COG0469	pyruvate kinase activity
HB674_RS13430	COG0281	malic enzyme
HB674_RS13435	COG0587	DNA-directed DNA polymerase activity
HB674_RS13455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HB674_RS13465	COG4109	DRTGG domain
HB674_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS13490	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB674_RS13500	COG0827	DNA restriction-modification system
HB674_RS13505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HB674_RS13510	COG3874	Sporulation protein YtfJ
HB674_RS13520	COG1714	RDD family
HB674_RS13525	COG0616	signal peptide processing
HB674_RS13530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB674_RS13535	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HB674_RS13540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB674_RS13555	COG1104	cysteine desulfurase activity
HB674_RS13560	COG1114	Component of the transport system for branched-chain amino acids
HB674_RS13570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HB674_RS13575	COG1309	transcriptional regulator
HB674_RS13580	COG1956	GAF domain-containing protein
HB674_RS13585	COG2203	Gaf domain
HB674_RS13585	COG2199	diguanylate cyclase activity
HB674_RS13600	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS13605	COG4282	regulation of fungal-type cell wall biogenesis
HB674_RS13650	COG1017	nitric oxide dioxygenase activity
HB674_RS13650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB674_RS13665	COG0693	protein deglycase activity
HB674_RS13680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB674_RS13685	COG1378	Sugar-specific transcriptional regulator TrmB
HB674_RS13705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB674_RS13710	COG0454	-acetyltransferase
HB674_RS13715	COG0517	IMP dehydrogenase activity
HB674_RS13720	COG0123	including yeast histone deacetylase and acetoin utilization protein
HB674_RS13725	COG1360	Flagellar Motor Protein
HB674_RS13730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB674_RS13735	COG1609	Transcriptional regulator
HB674_RS13740	COG1605	Chorismate mutase
HB674_RS13740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HB674_RS13745	COG3118	belongs to the thioredoxin family
HB674_RS13750	COG4980	gas vesicle protein
HB674_RS13755	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HB674_RS13765	COG1674	ftsk spoiiie
HB674_RS13770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB674_RS13780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS13790	COG1363	Peptidase, m42
HB674_RS13795	COG5584	Small secreted protein
HB674_RS13800	COG0281	malic enzyme
HB674_RS13805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB674_RS13820	COG0510	thiamine kinase activity
HB674_RS13825	COG1597	lipid kinase activity
HB674_RS13835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HB674_RS13840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB674_RS13845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB674_RS13850	COG2252	PERMEase
HB674_RS13855	COG4473	ABC transporter
HB674_RS13860	COG1131	(ABC) transporter
HB674_RS13865	COG1349	DNA-binding transcription factor activity
HB674_RS13870	COG1187	pseudouridine synthase activity
HB674_RS13875	COG2244	polysaccharide biosynthetic process
HB674_RS13880	COG2081	HI0933 family
HB674_RS13885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB674_RS13895	COG1609	Transcriptional regulator
HB674_RS13900	COG1653	transport
HB674_RS13905	COG1175	transmembrane transport
HB674_RS13910	COG0395	ABC-type sugar transport system, permease component
HB674_RS13915	COG1486	melibiose metabolic process
HB674_RS13925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB674_RS13940	COG1366	Belongs to the anti-sigma-factor antagonist family
HB674_RS13940	COG2202	Pas domain
HB674_RS13945	COG2814	Major facilitator Superfamily
HB674_RS13950	COG5522	Integral membrane protein (intg_mem_TP0381)
HB674_RS13955	COG0577	efflux transmembrane transporter activity
HB674_RS13960	COG1136	(ABC) transporter
HB674_RS13965	COG2205	protein histidine kinase activity
HB674_RS13970	COG0745	RESPONSE REGULATOR receiver
HB674_RS13975	COG0577	efflux transmembrane transporter activity
HB674_RS13980	COG1136	(ABC) transporter
HB674_RS14000	COG1131	(ABC) transporter
HB674_RS14005	COG1725	Transcriptional regulator
HB674_RS14015	COG1242	4 iron, 4 sulfur cluster binding
HB674_RS14020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HB674_RS14030	COG0584	glycerophosphoryl diester phosphodiesterase
HB674_RS14040	COG2267	carboxylic ester hydrolase activity
HB674_RS14045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB674_RS14050	COG1113	amino acid transport
HB674_RS14055	COG0367	asparagine synthase
HB674_RS14075	COG1506	peptidase
HB674_RS14080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB674_RS14085	COG1116	anion transmembrane transporter activity
HB674_RS14090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB674_RS14095	COG0494	nUDIX hydrolase
HB674_RS14100	COG4824	toxin secretion phage lysis holin
HB674_RS14105	COG0783	Belongs to the Dps family
HB674_RS14130	COG0288	reversible hydration of carbon dioxide
HB674_RS14140	COG1271	oxidase subunit
HB674_RS14145	COG1294	oxidase, subunit
HB674_RS14160	COG4948	Mandelate Racemase Muconate Lactonizing
HB674_RS14170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HB674_RS14175	COG0596	Alpha beta hydrolase
HB674_RS14185	COG1169	isochorismate synthase
HB674_RS14190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB674_RS14195	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HB674_RS14320	COG3859	Proton-coupled thiamine transporter YuaJ
HB674_RS14325	COG2268	Band 7 protein
HB674_RS14330	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB674_RS14335	COG2318	DinB family
HB674_RS14345	COG1454	alcohol dehydrogenase
HB674_RS14350	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS14355	COG1510	regulation of RNA biosynthetic process
HB674_RS14365	COG0569	domain protein
HB674_RS14370	COG1705	Flagellar rod assembly protein muramidase FlgJ
HB674_RS14375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB674_RS14375	COG1017	nitric oxide dioxygenase activity
HB674_RS14400	COG0628	permease
HB674_RS14405	COG0673	inositol 2-dehydrogenase activity
HB674_RS14410	COG0693	protein deglycase activity
HB674_RS14415	COG0840	transmembrane signaling receptor activity
HB674_RS14420	COG0840	transmembrane signaling receptor activity
HB674_RS14425	COG0840	transmembrane signaling receptor activity
HB674_RS14430	COG0840	transmembrane signaling receptor activity
HB674_RS14445	COG2070	2-Nitropropane dioxygenase
HB674_RS14450	COG0432	Pfam Uncharacterised protein family UPF0047
HB674_RS14455	COG0366	Alpha amylase catalytic
HB674_RS14460	COG1253	flavin adenine dinucleotide binding
HB674_RS14465	COG2738	Putative neutral zinc metallopeptidase
HB674_RS14480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB674_RS14505	COG1335	isochorismatase
HB674_RS14510	COG1979	alcohol dehydrogenase
HB674_RS14515	COG1979	alcohol dehydrogenase
HB674_RS14520	COG2155	Conserved Protein
HB674_RS14525	COG1098	S1 RNA binding domain
HB674_RS14530	COG0436	Aminotransferase
HB674_RS14535	COG1522	sequence-specific DNA binding
HB674_RS14540	COG2267	carboxylic ester hydrolase activity
HB674_RS14550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HB674_RS14555	COG2205	protein histidine kinase activity
HB674_RS14565	COG5018	Exonuclease
HB674_RS14570	COG2814	Major facilitator Superfamily
HB674_RS14575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB674_RS14580	COG3011	Protein conserved in bacteria
HB674_RS14590	COG3290	protein histidine kinase activity
HB674_RS14595	COG4565	transcriptional regulatory protein
HB674_RS14625	COG2111	Na H antiporter
HB674_RS14625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB674_RS14630	COG2111	Na H antiporter
HB674_RS14635	COG1006	Multisubunit Na H antiporter MnhC subunit
HB674_RS14640	COG0651	ATP synthesis coupled electron transport
HB674_RS14645	COG1863	multisubunit Na H antiporter MnhE subunit
HB674_RS14650	COG2212	antiporter activity
HB674_RS14655	COG1320	monovalent cation:proton antiporter activity
HB674_RS14660	COG2050	protein possibly involved in aromatic compounds catabolism
HB674_RS14665	COG2197	response regulator
HB674_RS14670	COG4585	Histidine kinase
HB674_RS14700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HB674_RS14705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HB674_RS14710	COG1335	isochorismatase
HB674_RS14715	COG5506	Protein of unknown function (DUF1694)
HB674_RS14730	COG0628	permease
HB674_RS14740	COG1418	mRNA catabolic process
HB674_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS14755	COG1511	domain protein
HB674_RS14760	COG0433	COG0433 Predicted ATPase
HB674_RS14760	COG1674	ftsk spoiiie
HB674_RS14765	COG4499	WXG100 protein secretion system (Wss), protein YukC
HB674_RS14770	COG5417	Belongs to the EsaB family
HB674_RS14775	COG4842	Belongs to the WXG100 family
HB674_RS14780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HB674_RS14780	COG2508	Transcriptional regulator
HB674_RS14785	COG0686	Belongs to the AlaDH PNT family
HB674_RS14790	COG5634	Uncharacterized conserved protein (DUF2278)
HB674_RS14795	COG3251	PFAM MbtH domain protein
HB674_RS14800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB674_RS14805	COG1535	isochorismatase
HB674_RS14805	COG3433	isochorismatase activity
HB674_RS14810	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB674_RS14815	COG1169	isochorismate synthase
HB674_RS14820	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS14825	COG2819	hydrolase of the alpha beta superfamily
HB674_RS14830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB674_RS14835	COG1268	BioY protein
HB674_RS14840	COG2056	Na+-H+ antiporter family
HB674_RS14850	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HB674_RS14855	COG3584	3D domain protein
HB674_RS14870	COG1252	NADH dehydrogenase
HB674_RS14900	COG1131	(ABC) transporter
HB674_RS14920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB674_RS14925	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HB674_RS14930	COG0316	Belongs to the HesB IscA family
HB674_RS14940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB674_RS14950	COG1252	NADH dehydrogenase
HB674_RS14955	COG4837	Protein of unknown function (DUF1462)
HB674_RS14960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HB674_RS14965	COG0823	Involved in the tonB-independent uptake of proteins
HB674_RS14965	COG4946	Tricorn protease homolog
HB674_RS14965	COG1506	peptidase
HB674_RS14975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB674_RS14980	COG0460	homoserine dehydrogenase
HB674_RS14985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB674_RS14990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB674_RS14995	COG0647	UMP catabolic process
HB674_RS15000	COG2445	Protein of unknown function DUF86
HB674_RS15005	COG4470	Protein conserved in bacteria
HB674_RS15015	COG0739	heme binding
HB674_RS15025	COG0737	Belongs to the 5'-nucleotidase family
HB674_RS15030	COG0730	response to heat
HB674_RS15035	COG1801	Protein of unknown function DUF72
HB674_RS15050	COG2508	Transcriptional regulator
HB674_RS15070	COG2814	Major facilitator Superfamily
HB674_RS15075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB674_RS15080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB674_RS15085	COG2356	endonuclease I
HB674_RS15090	COG3842	ATPase activity
HB674_RS15095	COG2188	Transcriptional regulator
HB674_RS15100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB674_RS15105	COG0395	ABC-type sugar transport system, permease component
HB674_RS15110	COG1175	transmembrane transport
HB674_RS15115	COG1653	transport
HB674_RS15120	COG2222	sugar isomerase
HB674_RS15125	COG0789	Transcriptional regulator
HB674_RS15150	COG0322	excinuclease ABC activity
HB674_RS15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB674_RS15175	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS15180	COG0719	Fe-S assembly protein
HB674_RS15185	COG0822	iron-sulfur transferase activity
HB674_RS15190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB674_RS15195	COG0719	Fe-S assembly protein
HB674_RS15200	COG0396	ATPase activity
HB674_RS15210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB674_RS15215	COG1464	Belongs to the NlpA lipoprotein family
HB674_RS15220	COG2011	ABC-type metal ion transport system permease component
HB674_RS15225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB674_RS15235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB674_RS15240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HB674_RS15255	COG1393	Belongs to the ArsC family
HB674_RS15260	COG1960	acyl-CoA dehydrogenase activity
HB674_RS15265	COG0183	Belongs to the thiolase family
HB674_RS15270	COG1024	Enoyl-CoA hydratase
HB674_RS15270	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB674_RS15290	COG5577	PFAM Coat F domain
HB674_RS15295	COG1846	Transcriptional regulator
HB674_RS15300	COG0477	Major facilitator Superfamily
HB674_RS15305	COG1942	4-Oxalocrotonate Tautomerase
HB674_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS15315	COG0583	DNA-binding transcription factor activity
HB674_RS15325	COG0583	DNA-binding transcription factor activity
HB674_RS15345	COG1120	ATPase activity
HB674_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS15365	COG0783	Belongs to the Dps family
HB674_RS15370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB674_RS15375	COG0745	RESPONSE REGULATOR receiver
HB674_RS15380	COG2205	protein histidine kinase activity
HB674_RS15380	COG2770	Histidine kinase
HB674_RS15390	COG1309	transcriptional regulator
HB674_RS15395	COG0114	fumarate hydratase activity
HB674_RS15405	COG0697	spore germination
HB674_RS15410	COG0814	amino acid
HB674_RS15420	COG2197	response regulator
HB674_RS15425	COG4585	Histidine kinase
HB674_RS15430	COG4758	membrane
HB674_RS15435	COG3595	metallopeptidase activity
HB674_RS15440	COG1842	Phage shock protein A
HB674_RS15445	COG4758	membrane
HB674_RS15450	COG2814	Major facilitator Superfamily
HB674_RS15455	COG2096	Adenosyltransferase
HB674_RS15460	COG1120	ATPase activity
HB674_RS15465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS15470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB674_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS15480	COG3386	PFAM SMP-30 Gluconolaconase
HB674_RS15485	COG2205	protein histidine kinase activity
HB674_RS15490	COG0745	RESPONSE REGULATOR receiver
HB674_RS15500	COG1191	sigma factor activity
HB674_RS15510	COG2140	Oxalate decarboxylase
HB674_RS15520	COG1120	ATPase activity
HB674_RS15525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS15530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS15535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB674_RS15540	COG0531	amino acid
HB674_RS15550	COG1988	membrane-bound metal-dependent
HB674_RS15555	COG1368	sulfuric ester hydrolase activity
HB674_RS15560	COG1910	domain protein
HB674_RS15565	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB674_RS15570	COG4149	molybdate abc transporter
HB674_RS15575	COG2197	response regulator
HB674_RS15580	COG3850	Histidine kinase
HB674_RS15585	COG1131	(ABC) transporter
HB674_RS15595	COG0842	Transport permease protein
HB674_RS15600	COG0656	L-ascorbic acid biosynthetic process
HB674_RS15620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB674_RS15625	COG3973	AAA domain
HB674_RS15630	COG2860	membrane
HB674_RS15640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB674_RS15645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB674_RS15650	COG2217	Heavy metal translocating P-type atpase
HB674_RS15655	COG2217	Heavy metal translocating P-type atpase
HB674_RS15660	COG2608	mercury ion transmembrane transporter activity
HB674_RS15665	COG1937	Protein conserved in bacteria
HB674_RS15670	COG0673	inositol 2-dehydrogenase activity
HB674_RS15680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS15685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB674_RS15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS15695	COG1126	abc transporter atp-binding protein
HB674_RS15700	COG0765	amino acid transport
HB674_RS15705	COG0765	amino acid transport
HB674_RS15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB674_RS15715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB674_RS15720	COG0454	-acetyltransferase
HB674_RS15725	COG0583	DNA-binding transcription factor activity
HB674_RS15730	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS15775	COG0557	exoribonuclease II activity
HB674_RS15780	COG1647	Serine aminopeptidase, S33
HB674_RS15785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB674_RS15790	COG1476	TRANSCRIPTIONal
HB674_RS15795	COG1396	sequence-specific DNA binding
HB674_RS15800	COG1396	sequence-specific DNA binding
HB674_RS15805	COG1733	regulation of RNA biosynthetic process
HB674_RS15830	COG1131	(ABC) transporter
HB674_RS15835	COG1174	glycine betaine transport
HB674_RS15840	COG1732	Glycine betaine
HB674_RS15845	COG1174	glycine betaine transport
HB674_RS15850	COG1125	glycine betaine transport
HB674_RS15850	COG0517	IMP dehydrogenase activity
HB674_RS15855	COG1510	regulation of RNA biosynthetic process
HB674_RS15860	COG1174	glycine betaine transport
HB674_RS15865	COG1732	Glycine betaine
HB674_RS15870	COG1174	glycine betaine transport
HB674_RS15875	COG1125	glycine betaine transport
HB674_RS15875	COG0517	IMP dehydrogenase activity
HB674_RS15880	COG1510	regulation of RNA biosynthetic process
HB674_RS15885	COG2095	MarC family integral membrane protein
HB674_RS15890	COG3064	Membrane
HB674_RS15895	COG4640	response to antibiotic
HB674_RS15900	COG0456	acetyltransferase
HB674_RS15915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB674_RS15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB674_RS15940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB674_RS15950	COG2234	aminopeptidase activity
HB674_RS15970	COG0126	phosphoglycerate kinase activity
HB674_RS15975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB674_RS15980	COG2390	Transcriptional regulator
HB674_RS15985	COG2814	Major facilitator Superfamily
HB674_RS15990	COG1609	Transcriptional regulator
HB674_RS15995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS16005	COG0583	DNA-binding transcription factor activity
HB674_RS16010	COG0697	spore germination
HB674_RS16015	COG1113	amino acid transport
HB674_RS16020	COG1609	Transcriptional regulator
HB674_RS16030	COG0561	phosphatase activity
HB674_RS16035	COG1737	Transcriptional regulator
HB674_RS16040	COG1070	Carbohydrate kinase
HB674_RS16080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS16085	COG2186	Transcriptional regulator
HB674_RS16090	COG1620	l-lactate permease
HB674_RS16095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HB674_RS16105	COG5039	Polysaccharide pyruvyl transferase
HB674_RS16110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB674_RS16115	COG0110	maltose O-acetyltransferase activity
HB674_RS16120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB674_RS16125	COG2244	polysaccharide biosynthetic process
HB674_RS16130	COG1216	Glycosyl transferase, family 2
HB674_RS16135	COG5039	Polysaccharide pyruvyl transferase
HB674_RS16140	COG1216	Glycosyl transferase, family 2
HB674_RS16150	COG0438	transferase activity, transferring glycosyl groups
HB674_RS16155	COG1215	transferase activity, transferring glycosyl groups
HB674_RS16160	COG0438	transferase activity, transferring glycosyl groups
HB674_RS16165	COG1086	Polysaccharide biosynthesis protein
HB674_RS16170	COG0489	protein tyrosine kinase activity
HB674_RS16175	COG3944	biosynthesis protein
HB674_RS16180	COG1396	sequence-specific DNA binding
HB674_RS16185	COG2272	Belongs to the type-B carboxylesterase lipase family
HB674_RS16190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB674_RS16195	COG2364	Membrane
HB674_RS16200	COG0456	acetyltransferase
HB674_RS16205	COG3479	Phenolic acid decarboxylase
HB674_RS16255	COG2223	nitrite transmembrane transporter activity
HB674_RS16260	COG1609	Transcriptional regulator
HB674_RS16270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB674_RS16275	COG0366	Alpha amylase catalytic
HB674_RS16280	COG1554	hydrolase, family 65, central catalytic
HB674_RS16285	COG5521	maltodextrose utilization protein MalA
HB674_RS16290	COG3833	ABC-type maltose transport systems, permease component
HB674_RS16295	COG1175	transmembrane transport
HB674_RS16300	COG2182	Extracellular solute-binding protein
HB674_RS16305	COG0366	Alpha amylase catalytic
HB674_RS16310	COG1609	Transcriptional regulator
HB674_RS16315	COG1611	Belongs to the LOG family
HB674_RS16320	COG1694	Mazg nucleotide pyrophosphohydrolase
HB674_RS16325	COG0659	secondary active sulfate transmembrane transporter activity
HB674_RS16330	COG0288	reversible hydration of carbon dioxide
HB674_RS16340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB674_RS16345	COG4290	ribonuclease
HB674_RS16350	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HB674_RS16355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS16365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HB674_RS16375	COG1051	belongs to the nudix hydrolase family
HB674_RS16380	COG0492	ferredoxin-NADP+ reductase activity
HB674_RS16385	COG3883	PFAM NLP P60 protein
HB674_RS16385	COG0791	NLP P60 protein
HB674_RS16390	COG0457	Tetratricopeptide repeat
HB674_RS16395	COG5002	protein histidine kinase activity
HB674_RS16400	COG0745	RESPONSE REGULATOR receiver
HB674_RS16405	COG1132	(ABC) transporter
HB674_RS16410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB674_RS16410	COG0140	phosphoribosyl-ATP diphosphatase activity
HB674_RS16435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB674_RS16450	COG4990	cell redox homeostasis
HB674_RS16455	COG0110	maltose O-acetyltransferase activity
HB674_RS16475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HB674_RS16485	COG2188	Transcriptional regulator
HB674_RS16490	COG1309	transcriptional regulator
HB674_RS16495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB674_RS16500	COG1950	PFAM Membrane protein of
HB674_RS16505	COG1983	PspC domain protein
HB674_RS16510	COG3595	metallopeptidase activity
HB674_RS16525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB674_RS16535	COG4897	Protein conserved in bacteria
HB674_RS16540	COG3848	Pyruvate phosphate dikinase
HB674_RS16540	COG0574	Belongs to the PEP-utilizing enzyme family
HB674_RS16545	COG1309	transcriptional regulator
HB674_RS16550	COG2814	Major facilitator Superfamily
HB674_RS16565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB674_RS16575	COG0793	Belongs to the peptidase S41A family
HB674_RS16575	COG3409	Peptidoglycan-binding domain 1 protein
HB674_RS16580	COG3420	alginic acid biosynthetic process
HB674_RS16585	COG2177	Part of the ABC transporter FtsEX involved in
HB674_RS16590	COG2884	Cell division ATP-binding protein ftsE
HB674_RS16595	COG2010	Cytochrome c
HB674_RS16600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS16615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB674_RS16630	COG1516	flagellar protein fliS
HB674_RS16635	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HB674_RS16640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB674_RS16660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB674_RS16665	COG1256	bacterial-type flagellum assembly
HB674_RS16665	COG4786	Flagellar basal body rod
HB674_RS16670	COG3418	PFAM FlgN family protein
HB674_RS16675	COG2747	anti-sigma28 factor FlgM
HB674_RS16685	COG1040	competence protein
HB674_RS16695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HB674_RS16700	COG1307	EDD domain protein, DegV family
HB674_RS16705	COG2197	response regulator
HB674_RS16710	COG4585	Histidine kinase
HB674_RS16715	COG1739	Uncharacterized protein family UPF0029
HB674_RS16720	COG1316	TRANSCRIPTIONal
HB674_RS16725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB674_RS16730	COG0438	transferase activity, transferring glycosyl groups
HB674_RS16735	COG1215	transferase activity, transferring glycosyl groups
HB674_RS16740	COG3206	protein involved in exopolysaccharide biosynthesis
HB674_RS16745	COG3307	-O-antigen
HB674_RS16750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB674_RS16755	COG0297	glycogen (starch) synthase activity
HB674_RS16755	COG0438	transferase activity, transferring glycosyl groups
HB674_RS16760	COG2244	polysaccharide biosynthetic process
HB674_RS16770	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB674_RS16770	COG2247	cell wall binding repeat
HB674_RS16775	COG2385	sporulation resulting in formation of a cellular spore
HB674_RS16775	COG2247	cell wall binding repeat
HB674_RS16785	COG1316	TRANSCRIPTIONal
HB674_RS16790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB674_RS16795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB674_RS16800	COG1134	teichoic acid transport
HB674_RS16805	COG1682	transport, permease protein
HB674_RS16810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB674_RS16820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB674_RS16825	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HB674_RS16830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB674_RS16835	COG4193	domain, Protein
HB674_RS16840	COG1482	cell wall glycoprotein biosynthetic process
HB674_RS16845	COG0697	spore germination
HB674_RS16850	COG0814	amino acid
HB674_RS16860	COG1215	transferase activity, transferring glycosyl groups
HB674_RS16865	COG2814	Major facilitator Superfamily
HB674_RS16870	COG1316	TRANSCRIPTIONal
HB674_RS16875	COG0561	phosphatase activity
HB674_RS16880	COG2433	Pfam Transposase IS66
HB674_RS16885	COG0791	NLP P60 protein
HB674_RS16895	COG2843	Capsule synthesis protein
HB674_RS16905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HB674_RS16910	COG0697	spore germination
HB674_RS16915	COG0814	amino acid
HB674_RS16925	COG1609	Transcriptional regulator
HB674_RS16930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB674_RS16940	COG1129	ABC transporter
HB674_RS16945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB674_RS16950	COG1879	ABC-type sugar transport system periplasmic component
HB674_RS16955	COG3103	Sh3 type 3 domain protein
HB674_RS16960	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB674_RS16965	COG3527	Alpha-acetolactate decarboxylase
HB674_RS16970	COG0028	Belongs to the TPP enzyme family
HB674_RS16975	COG0583	DNA-binding transcription factor activity
HB674_RS16980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HB674_RS16995	COG5337	Spore coat protein CotH
HB674_RS17005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB674_RS17015	COG0405	Gamma-glutamyltransferase
HB674_RS17020	COG1522	sequence-specific DNA binding
HB674_RS17025	COG2059	Chromate
HB674_RS17030	COG2059	Chromate
HB674_RS17040	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB674_RS17045	COG0583	DNA-binding transcription factor activity
HB674_RS17075	COG5444	nuclease activity
HB674_RS17090	COG3878	Protein conserved in bacteria
HB674_RS17095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB674_RS17100	COG4464	protein tyrosine phosphatase activity
HB674_RS17105	COG0489	protein tyrosine kinase activity
HB674_RS17110	COG3944	biosynthesis protein
HB674_RS17120	COG4715	Zinc finger, swim domain protein
HB674_RS17125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HB674_RS17130	COG0561	phosphatase activity
HB674_RS17135	COG1349	DNA-binding transcription factor activity
HB674_RS17140	COG0629	single-stranded DNA binding
HB674_RS17165	COG0457	Tetratricopeptide repeat
HB674_RS17170	COG4786	Flagellar basal body rod
HB674_RS17175	COG4786	Flagellar basal body rod
HB674_RS17180	COG1077	Cell shape determining protein MreB Mrl
HB674_RS17185	COG1609	Transcriptional regulator
HB674_RS17190	COG1846	Transcriptional regulator
HB674_RS17195	COG2814	Major facilitator Superfamily
HB674_RS17200	COG1953	Uracil, thiamine, allantoin
HB674_RS17205	COG0477	Major facilitator Superfamily
HB674_RS17210	COG1335	isochorismatase
HB674_RS17215	COG0004	ammonium transporteR
HB674_RS17220	COG0347	Belongs to the P(II) protein family
HB674_RS17225	COG0772	Belongs to the SEDS family
HB674_RS17230	COG0671	phosphoesterase, PA-phosphatase related
HB674_RS17240	COG0739	heme binding
HB674_RS17245	COG1247	-acetyltransferase
HB674_RS17260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB674_RS17270	COG0726	polysaccharide deacetylase
HB674_RS17280	COG1959	2 iron, 2 sulfur cluster binding
HB674_RS17295	COG0831	urea catabolic process
HB674_RS17300	COG3237	CsbD-like
HB674_RS17305	COG1994	Peptidase M50
HB674_RS17310	COG0457	Tetratricopeptide repeat
HB674_RS17320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB674_RS17330	COG2304	oxidoreductase activity
HB674_RS17335	COG2304	oxidoreductase activity
HB674_RS17340	COG2385	sporulation resulting in formation of a cellular spore
HB674_RS17345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB674_RS17355	COG4836	Membrane
HB674_RS17425	COG0698	ribose 5-phosphate isomerase
HB674_RS17430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB674_RS17440	COG0009	L-threonylcarbamoyladenylate synthase
HB674_RS17445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HB674_RS17465	COG2890	protein-(glutamine-N5) methyltransferase activity
HB674_RS17470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HB674_RS17475	COG0346	lactoylglutathione lyase activity
HB674_RS17480	COG0789	Transcriptional regulator
HB674_RS17485	COG0679	Auxin Efflux Carrier
HB674_RS17490	COG0281	malic enzyme
HB674_RS17505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HB674_RS17510	COG1494	fructose-1,6-bisphosphatase
HB674_RS17515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB674_RS17525	COG0191	fructose-bisphosphate aldolase activity
HB674_RS17530	COG2204	response regulator
HB674_RS17535	COG4821	SIS domain
HB674_RS17550	COG2181	nitrate reductase activity
HB674_RS17550	COG0247	lactate metabolic process
HB674_RS17555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB674_RS17570	COG1132	(ABC) transporter
HB674_RS17575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB674_RS17585	COG2181	nitrate reductase activity
HB674_RS17590	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HB674_RS17595	COG1140	nitrate reductase beta subunit
HB674_RS17600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HB674_RS17605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB674_RS17615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB674_RS17620	COG2223	nitrite transmembrane transporter activity
HB674_RS17630	COG4506	Protein conserved in bacteria
HB674_RS17640	COG3391	amine dehydrogenase activity
HB674_RS17645	COG3391	amine dehydrogenase activity
HB674_RS17650	COG0457	Tetratricopeptide repeat
HB674_RS17660	COG0010	Belongs to the arginase family
HB674_RS17665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HB674_RS17670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB674_RS17685	COG1994	Peptidase M50
HB674_RS17690	COG1942	4-Oxalocrotonate Tautomerase
HB674_RS17695	COG1846	Transcriptional regulator
HB674_RS17700	COG0531	amino acid
HB674_RS17705	COG3465	dGTPase activity
HB674_RS17710	COG1078	dGTPase activity
HB674_RS17725	COG1695	Transcriptional regulator
HB674_RS17735	COG1131	(ABC) transporter
HB674_RS17740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HB674_RS17770	COG0583	DNA-binding transcription factor activity
HB674_RS17775	COG2855	membrane
HB674_RS17780	COG0280	phosphate acetyltransferase
HB674_RS17790	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS17795	COG0436	Aminotransferase
HB674_RS17825	COG2814	Major facilitator Superfamily
HB674_RS17830	COG2814	Major facilitator Superfamily
HB674_RS17835	COG0833	amino acid
HB674_RS17840	COG4187	Peptidase family M20/M25/M40
HB674_RS17845	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS17850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB674_RS17855	COG2205	protein histidine kinase activity
HB674_RS17860	COG0745	RESPONSE REGULATOR receiver
HB674_RS17875	COG1131	(ABC) transporter
HB674_RS17880	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HB674_RS17885	COG1091	dTDP-4-dehydrorhamnose reductase activity
HB674_RS17890	COG1088	dTDP-glucose 4,6-dehydratase activity
HB674_RS17895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HB674_RS17900	COG3980	spore coat polysaccharide biosynthesis protein
HB674_RS17905	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HB674_RS17910	COG2089	acid synthase
HB674_RS17915	COG0456	acetyltransferase
HB674_RS17920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB674_RS17925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB674_RS17930	COG0463	Glycosyl transferase, family 2
HB674_RS17940	COG2363	Small membrane protein
HB674_RS17945	COG2233	PERMEase
HB674_RS17960	COG1216	Glycosyl transferase, family 2
HB674_RS17975	COG1695	Transcriptional regulator
HB674_RS17980	COG0351	phosphomethylpyrimidine kinase
HB674_RS17990	COG1621	beta-fructofuranosidase activity
HB674_RS17995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB674_RS17995	COG1263	PTS System
HB674_RS18000	COG3711	transcriptional antiterminator
HB674_RS18010	COG1404	Belongs to the peptidase S8 family
HB674_RS18015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB674_RS18020	COG0778	Nitroreductase
HB674_RS18025	COG0772	Belongs to the SEDS family
HB674_RS18030	COG0454	-acetyltransferase
HB674_RS18050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB674_RS18055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB674_RS18060	COG2261	transglycosylase associated protein
HB674_RS18065	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HB674_RS18070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HB674_RS18075	COG2246	polysaccharide biosynthetic process
HB674_RS18080	COG1309	transcriptional regulator
HB674_RS18100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB674_RS18105	COG2837	iron assimilation
HB674_RS18120	COG0583	DNA-binding transcription factor activity
HB674_RS18130	COG1346	cytolysis
HB674_RS18135	COG4895	conserved protein (DUF2196)
HB674_RS18140	COG0789	Transcriptional regulator
HB674_RS18145	COG5504	Zn-dependent protease
HB674_RS18150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HB674_RS18155	COG0346	lactoylglutathione lyase activity
HB674_RS18160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS18165	COG1404	Belongs to the peptidase S8 family
HB674_RS18170	COG1442	glycosyl transferase family 8
HB674_RS18175	COG2357	RelA SpoT domain protein
HB674_RS18180	COG1575	Belongs to the MenA family. Type 1 subfamily
HB674_RS18195	COG1696	Membrane protein involved in D-alanine export
HB674_RS18205	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HB674_RS18210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB674_RS18215	COG1486	melibiose metabolic process
HB674_RS18220	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB674_RS18225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS18230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS18235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB674_RS18235	COG3711	transcriptional antiterminator
HB674_RS18245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB674_RS18260	COG0640	Transcriptional regulator
HB674_RS18265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HB674_RS18270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS18275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HB674_RS18280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HB674_RS18285	COG2723	6-phospho-beta-galactosidase activity
HB674_RS18295	COG1482	cell wall glycoprotein biosynthetic process
HB674_RS18305	COG0753	catalase activity
HB674_RS18310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HB674_RS18315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB674_RS18335	COG3279	Response regulator of the LytR AlgR family
HB674_RS18355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB674_RS18360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HB674_RS18365	COG4988	ABC transporter
HB674_RS18370	COG1294	oxidase, subunit
HB674_RS18375	COG1271	oxidase subunit
HB674_RS18380	COG3493	citrate carrier protein
HB674_RS18385	COG0726	polysaccharide deacetylase
HB674_RS18390	COG3842	ATPase activity
HB674_RS18395	COG2508	Transcriptional regulator
HB674_RS18400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS18410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB674_RS18425	COG4894	glucomannan catabolic process
HB674_RS18430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB674_RS18435	COG0500	methyltransferase
HB674_RS18440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB674_RS18455	COG0693	protein deglycase activity
HB674_RS18455	COG0753	catalase activity
HB674_RS18460	COG2851	Citrate transporter
HB674_RS18465	COG2273	Hydrolase Family 16
HB674_RS18475	COG2270	Major facilitator Superfamily
HB674_RS18480	COG0513	Belongs to the DEAD box helicase family
HB674_RS18490	COG0697	spore germination
HB674_RS18495	COG0589	response to stress
HB674_RS18555	COG3507	Belongs to the glycosyl hydrolase 43 family
HB674_RS18580	COG0010	Belongs to the arginase family
HB674_RS18585	COG0833	amino acid
HB674_RS18590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HB674_RS18595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB674_RS18605	COG2390	Transcriptional regulator
HB674_RS18610	COG0561	phosphatase activity
HB674_RS18640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB674_RS18645	COG5294	Protein conserved in bacteria
HB674_RS18650	COG0577	efflux transmembrane transporter activity
HB674_RS18655	COG1136	(ABC) transporter
HB674_RS18660	COG2205	protein histidine kinase activity
HB674_RS18665	COG0745	RESPONSE REGULATOR receiver
HB674_RS18670	COG2205	protein histidine kinase activity
HB674_RS18675	COG0745	RESPONSE REGULATOR receiver
HB674_RS18705	COG1082	Xylose isomerase domain protein TIM barrel
HB674_RS18715	COG2814	Major facilitator Superfamily
HB674_RS18745	COG1349	DNA-binding transcription factor activity
HB674_RS18750	COG0667	Aldo Keto reductase
HB674_RS18755	COG2814	Major facilitator Superfamily
HB674_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS18775	COG2197	response regulator
HB674_RS18780	COG4585	Histidine kinase
HB674_RS18785	COG3239	Fatty acid desaturase
HB674_RS18790	COG1309	transcriptional regulator
HB674_RS18795	COG1012	belongs to the aldehyde dehydrogenase family
HB674_RS18800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB674_RS18810	COG0640	Transcriptional regulator
HB674_RS18815	COG2814	Major facilitator Superfamily
HB674_RS18820	COG1714	RDD family
HB674_RS18830	COG0450	alkyl hydroperoxide reductase
HB674_RS18835	COG3634	alkyl hydroperoxide reductase activity
HB674_RS18840	COG3177	Filamentation induced by cAMP protein fic
HB674_RS18845	COG1113	amino acid transport
HB674_RS18855	COG2080	2 iron, 2 sulfur cluster binding
HB674_RS18870	COG2068	MobA-Related Protein
HB674_RS18875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HB674_RS18930	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HB674_RS18935	COG0667	Aldo Keto reductase
HB674_RS18940	COG0456	acetyltransferase
HB674_RS18945	COG0457	Tetratricopeptide repeat
HB674_RS18950	COG0010	Belongs to the arginase family
HB674_RS18955	COG0833	amino acid
HB674_RS18960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB674_RS18965	COG5658	integral membrane protein
HB674_RS18970	COG0640	Transcriptional regulator
HB674_RS18975	COG3829	transcription factor binding
HB674_RS18985	COG0488	(ABC) transporter
HB674_RS19000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB674_RS19005	COG5002	protein histidine kinase activity
HB674_RS19005	COG3850	Histidine kinase
HB674_RS19010	COG0745	RESPONSE REGULATOR receiver
HB674_RS19015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB674_RS19020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB674_RS19025	COG4853	Protein conserved in bacteria
HB674_RS19030	COG4863	YycH protein
HB674_RS19035	COG5002	protein histidine kinase activity
HB674_RS19040	COG0745	RESPONSE REGULATOR receiver
HB674_RS19070	COG0346	lactoylglutathione lyase activity
HB674_RS19075	COG0305	Participates in initiation and elongation during chromosome replication
HB674_RS19090	COG3093	addiction module antidote protein HigA
HB674_RS19095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HB674_RS19100	COG0297	glycogen (starch) synthase activity
HB674_RS19110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HB674_RS19115	COG0438	transferase activity, transferring glycosyl groups
HB674_RS19135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HB674_RS19140	COG4241	membrane
HB674_RS19150	COG5577	PFAM Coat F domain
HB674_RS19155	COG1733	regulation of RNA biosynthetic process
HB674_RS19165	COG0697	spore germination
HB674_RS19170	COG1621	beta-fructofuranosidase activity
HB674_RS19175	COG1621	beta-fructofuranosidase activity
HB674_RS19185	COG2318	DinB family
HB674_RS19190	COG2211	Major facilitator Superfamily
HB674_RS19200	COG0778	Nitroreductase
HB674_RS19205	COG1846	Transcriptional regulator
HB674_RS19210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HB674_RS19215	COG1846	Transcriptional regulator
HB674_RS19220	COG2153	protein acetylation
HB674_RS19230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB674_RS19235	COG0583	DNA-binding transcription factor activity
HB674_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
HB674_RS19245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB674_RS19250	COG0697	spore germination
HB674_RS19255	COG1331	Highly conserved protein containing a thioredoxin domain
HB674_RS19280	COG1331	Highly conserved protein containing a thioredoxin domain
HB674_RS19285	COG1266	CAAX protease self-immunity
HB674_RS19290	COG0477	Major facilitator Superfamily
HB674_RS19290	COG2814	Major facilitator Superfamily
HB674_RS19295	COG0346	lactoylglutathione lyase activity
HB674_RS19300	COG1609	Transcriptional regulator
HB674_RS19305	COG0708	Exodeoxyribonuclease III
HB674_RS19310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB674_RS19315	COG2169	Transcriptional regulator
HB674_RS19325	COG0629	single-stranded DNA binding
HB674_RS19335	COG0012	GTP binding
HB674_RS19340	COG0243	molybdopterin cofactor binding
HB674_RS19345	COG4481	Protein conserved in bacteria
HB674_RS19350	COG3949	Membrane
HB674_RS19365	COG1475	DNA binding
HB674_RS19370	COG1192	Involved in chromosome partitioning
HB674_RS19395	COG1847	R3H domain protein
HB674_RS19400	COG0706	membrane insertase activity