locus-tag	class	description
HZT45_RS00010	COG0592	DNA-directed DNA polymerase activity
HZT45_RS00015	COG2501	S4 domain
HZT45_RS00030	COG0187	DNA topoisomerase II activity
HZT45_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZT45_RS00060	COG0516	GMP reductase activity
HZT45_RS00060	COG0517	IMP dehydrogenase activity
HZT45_RS00065	COG1686	Belongs to the peptidase S11 family
HZT45_RS00085	COG1929	Belongs to the glycerate kinase type-1 family
HZT45_RS00095	COG1428	Deoxynucleoside kinase
HZT45_RS00100	COG1428	Deoxynucleoside kinase
HZT45_RS00105	COG3858	chitin binding
HZT45_RS00105	COG1388	LysM domain
HZT45_RS00110	COG1335	isochorismatase
HZT45_RS00115	COG0590	tRNA wobble adenosine to inosine editing
HZT45_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZT45_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZT45_RS00170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HZT45_RS00175	COG3853	Toxic anion resistance protein (TelA)
HZT45_RS00180	COG1982	Orn Lys Arg decarboxylase major
HZT45_RS00190	COG3870	Protein conserved in bacteria
HZT45_RS00195	COG1728	Protein conserved in bacteria
HZT45_RS00200	COG0470	DNA polymerase III
HZT45_RS00205	COG1774	PSP1 C-terminal conserved region
HZT45_RS00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HZT45_RS00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZT45_RS00230	COG2002	toxin-antitoxin pair type II binding
HZT45_RS00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT45_RS00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT45_RS00240	COG0084	hydrolase, TatD family'
HZT45_RS00245	COG3583	domain protein
HZT45_RS00245	COG3584	3D domain protein
HZT45_RS00250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZT45_RS00255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZT45_RS00265	COG4466	Protein conserved in bacteria
HZT45_RS00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZT45_RS00285	COG0251	oxidation-reduction process
HZT45_RS00300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZT45_RS00320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZT45_RS00325	COG2002	toxin-antitoxin pair type II binding
HZT45_RS00330	COG2244	polysaccharide biosynthetic process
HZT45_RS00335	COG3956	TIGRFAM MazG family protein
HZT45_RS00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZT45_RS00355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZT45_RS00360	COG1098	S1 RNA binding domain
HZT45_RS00375	COG2208	phosphoserine phosphatase activity
HZT45_RS00380	COG2304	oxidoreductase activity
HZT45_RS00385	COG0515	serine threonine protein kinase
HZT45_RS00390	COG0037	tRNA processing
HZT45_RS00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZT45_RS00415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZT45_RS00420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZT45_RS00425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZT45_RS00430	COG0512	Glutamine amidotransferase of anthranilate synthase
HZT45_RS00435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZT45_RS00445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZT45_RS00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZT45_RS00455	COG1396	sequence-specific DNA binding
HZT45_RS00460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZT45_RS00465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZT45_RS00545	COG4463	regulation of RNA biosynthetic process
HZT45_RS00550	COG3880	PFAM UvrB UvrC protein
HZT45_RS00560	COG0542	response to heat
HZT45_RS00575	COG1132	(ABC) transporter
HZT45_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZT45_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HZT45_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HZT45_RS00615	COG1045	serine acetyltransferase
HZT45_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HZT45_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZT45_RS00635	COG3688	RNA-binding protein containing a PIN domain
HZT45_RS00640	COG1595	DNA-templated transcription, initiation
HZT45_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZT45_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HZT45_RS00680	COG2813	Specifically methylates the guanine in position
HZT45_RS00695	COG1358	cellular component organization or biogenesis
HZT45_RS00720	COG0596	Alpha beta hydrolase
HZT45_RS00830	COG0201	protein transport
HZT45_RS00840	COG0024	Methionine aminopeptidase
HZT45_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZT45_RS00875	COG1122	ATPase activity
HZT45_RS00880	COG1122	ATPase activity
HZT45_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZT45_RS00905	COG2226	methyltransferase
HZT45_RS00910	COG2318	DinB family
HZT45_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS00925	COG0489	protein tyrosine kinase activity
HZT45_RS00935	COG2194	sulfuric ester hydrolase activity
HZT45_RS00940	COG0726	polysaccharide deacetylase
HZT45_RS01000	COG0738	Major facilitator superfamily
HZT45_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
HZT45_RS01025	COG0385	Bile acid
HZT45_RS01030	COG2819	hydrolase of the alpha beta superfamily
HZT45_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZT45_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZT45_RS01050	COG2207	Transcriptional regulator
HZT45_RS01055	COG3876	Protein conserved in bacteria
HZT45_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
HZT45_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZT45_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS01070	COG1263	PTS System
HZT45_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT45_RS01085	COG1683	Conserved Protein
HZT45_RS01105	COG1595	DNA-templated transcription, initiation
HZT45_RS01110	COG5662	AntiSigma factor
HZT45_RS01115	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZT45_RS01120	COG4856	YbbR-like protein
HZT45_RS01160	COG1346	cytolysis
HZT45_RS01165	COG1380	Effector of murein hydrolase LrgA
HZT45_RS01170	COG1846	Transcriptional regulator
HZT45_RS01175	COG1113	amino acid transport
HZT45_RS01180	COG1011	Hydrolase
HZT45_RS01185	COG4585	Histidine kinase
HZT45_RS01190	COG2197	response regulator
HZT45_RS01195	COG1131	(ABC) transporter
HZT45_RS01235	COG0531	amino acid
HZT45_RS01240	COG0584	glycerophosphoryl diester phosphodiesterase
HZT45_RS01245	COG2271	Major facilitator Superfamily
HZT45_RS01255	COG2368	4-hydroxyphenylacetate
HZT45_RS01265	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS01280	COG0371	Dehydrogenase
HZT45_RS01290	COG1183	phosphatidylcholine synthase activity
HZT45_RS01295	COG0586	Pfam SNARE associated Golgi protein
HZT45_RS01300	COG0688	phosphatidylethanolamine metabolic process
HZT45_RS01315	COG1301	dicarboxylic acid transport
HZT45_RS01320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS01325	COG0833	amino acid
HZT45_RS01330	COG2040	homocysteine
HZT45_RS01335	COG1115	amino acid carrier protein
HZT45_RS01340	COG2066	Belongs to the glutaminase family
HZT45_RS01345	COG4191	Histidine kinase
HZT45_RS01350	COG0784	Response regulator, receiver
HZT45_RS01370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZT45_RS01375	COG0778	Nitroreductase
HZT45_RS01380	COG0346	lactoylglutathione lyase activity
HZT45_RS01385	COG2259	Doxx family
HZT45_RS01390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS01400	COG3773	Cell wall hydrolase
HZT45_RS01405	COG3540	Alkaline phosphatase
HZT45_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZT45_RS01415	COG0805	protein transport
HZT45_RS01425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZT45_RS01430	COG0477	Major facilitator Superfamily
HZT45_RS01435	COG1309	transcriptional regulator
HZT45_RS01440	COG0252	asparaginase activity
HZT45_RS01445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HZT45_RS01450	COG3012	SEC-C Motif Domain Protein
HZT45_RS01450	COG1405	negative regulation of cell septum assembly
HZT45_RS01455	COG0667	Aldo Keto reductase
HZT45_RS01465	COG1595	DNA-templated transcription, initiation
HZT45_RS01470	COG1595	DNA-templated transcription, initiation
HZT45_RS01475	COG1876	peptidase activity
HZT45_RS01480	COG0457	Tetratricopeptide repeat
HZT45_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS01490	COG0366	Alpha amylase catalytic
HZT45_RS01495	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZT45_RS01500	COG1121	(ABC) transporter
HZT45_RS01505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZT45_RS01510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS01515	COG2310	stress, protein
HZT45_RS01520	COG2310	stress, protein
HZT45_RS01525	COG2310	stress, protein
HZT45_RS01530	COG0861	Integral membrane protein TerC family
HZT45_RS01540	COG3853	Toxic anion resistance protein (TelA)
HZT45_RS01545	COG0477	Major facilitator Superfamily
HZT45_RS01550	COG0517	IMP dehydrogenase activity
HZT45_RS01550	COG4175	Glycine betaine
HZT45_RS01555	COG4176	ABC-type proline glycine betaine transport system permease component
HZT45_RS01560	COG2113	Glycine betaine
HZT45_RS01565	COG1473	amidohydrolase
HZT45_RS01570	COG1288	antiporter activity
HZT45_RS01580	COG0366	Alpha amylase catalytic
HZT45_RS01590	COG2814	Major facilitator Superfamily
HZT45_RS01595	COG1846	Transcriptional regulator
HZT45_RS01600	COG1280	lysine exporter protein (LysE YggA)
HZT45_RS01605	COG3403	YqcI/YcgG family
HZT45_RS01610	COG1113	amino acid transport
HZT45_RS01615	COG3665	Urea carboxylase-associated protein
HZT45_RS01635	COG1660	Displays ATPase and GTPase activities
HZT45_RS01640	COG1082	Xylose isomerase domain protein TIM barrel
HZT45_RS01645	COG2271	Major facilitator Superfamily
HZT45_RS01650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZT45_RS01655	COG3458	cephalosporin-C deacetylase activity
HZT45_RS01660	COG3541	Predicted nucleotidyltransferase
HZT45_RS01665	COG0506	proline dehydrogenase activity
HZT45_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS01675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT45_RS01680	COG2508	Transcriptional regulator
HZT45_RS01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZT45_RS01690	COG1587	Uroporphyrinogen-III synthase
HZT45_RS01695	COG2146	nitrite reductase [NAD(P)H] activity
HZT45_RS01700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZT45_RS01705	COG0243	molybdopterin cofactor binding
HZT45_RS01710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZT45_RS01715	COG2223	nitrite transmembrane transporter activity
HZT45_RS01720	COG0523	cobalamin synthesis protein
HZT45_RS01725	COG1063	alcohol dehydrogenase
HZT45_RS01730	COG1714	RDD family
HZT45_RS01740	COG2723	6-phospho-beta-galactosidase activity
HZT45_RS01750	COG3209	COG3209 Rhs family protein
HZT45_RS01755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HZT45_RS01760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HZT45_RS01765	COG1733	regulation of RNA biosynthetic process
HZT45_RS01775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS01780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS01785	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HZT45_RS01800	COG0697	spore germination
HZT45_RS01805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS01815	COG2364	Membrane
HZT45_RS01820	COG1126	abc transporter atp-binding protein
HZT45_RS01825	COG0765	amino acid transport
HZT45_RS01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS01835	COG0583	DNA-binding transcription factor activity
HZT45_RS01840	COG0163	prenyltransferase activity
HZT45_RS01845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZT45_RS01860	COG3104	oligopeptide transport
HZT45_RS01865	COG5434	Belongs to the glycosyl hydrolase 28 family
HZT45_RS01875	COG0697	spore germination
HZT45_RS01885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZT45_RS01890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS01895	COG0456	acetyltransferase
HZT45_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS01905	COG0765	amino acid transport
HZT45_RS01910	COG1126	abc transporter atp-binding protein
HZT45_RS01915	COG1473	amidohydrolase
HZT45_RS01920	COG2079	MmgE PrpD family protein
HZT45_RS01925	COG1136	(ABC) transporter
HZT45_RS01930	COG0577	efflux transmembrane transporter activity
HZT45_RS01935	COG0745	RESPONSE REGULATOR receiver
HZT45_RS01940	COG5002	protein histidine kinase activity
HZT45_RS01940	COG3850	Histidine kinase
HZT45_RS01945	COG0457	Tetratricopeptide repeat
HZT45_RS01960	COG0527	aspartate kinase activity
HZT45_RS01965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS01970	COG4605	iron ion homeostasis
HZT45_RS01975	COG4604	ABC transporter, ATP-binding protein
HZT45_RS01980	COG4607	ABC-type enterochelin transport system periplasmic component
HZT45_RS01985	COG2814	Major facilitator Superfamily
HZT45_RS01990	COG1309	transcriptional regulator
HZT45_RS01995	COG0778	Nitroreductase
HZT45_RS02000	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HZT45_RS02005	COG0640	Transcriptional regulator
HZT45_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS02015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS02020	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS02025	COG4975	Glucose uptake
HZT45_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS02035	COG4549	nuclear export factor GLE1
HZT45_RS02040	COG1276	copper resistance
HZT45_RS02040	COG2372	response to copper ion
HZT45_RS02045	COG1349	DNA-binding transcription factor activity
HZT45_RS02055	COG2213	PTS system mannitol-specific
HZT45_RS02060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS02070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZT45_RS02080	COG0561	phosphatase activity
HZT45_RS02090	COG1914	H( )-stimulated, divalent metal cation uptake system
HZT45_RS02100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZT45_RS02105	COG1984	allophanate hydrolase subunit 2
HZT45_RS02110	COG1414	Transcriptional regulator
HZT45_RS02115	COG2755	lipolytic protein G-D-S-L family
HZT45_RS02125	COG2329	Antibiotic biosynthesis monooxygenase
HZT45_RS02130	COG0768	penicillin binding
HZT45_RS02135	COG4989	oxidoreductase activity
HZT45_RS02140	COG3711	transcriptional antiterminator
HZT45_RS02145	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS02155	COG1917	Cupin 2, conserved barrel domain protein
HZT45_RS02160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT45_RS02165	COG3871	stress protein (general stress protein 26)
HZT45_RS02175	COG2814	Major facilitator Superfamily
HZT45_RS02180	COG1522	sequence-specific DNA binding
HZT45_RS02185	COG0551	DNA topoisomerase type I activity
HZT45_RS02185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZT45_RS02190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HZT45_RS02195	COG3706	GGDEF domain
HZT45_RS02200	COG5298	Protein conserved in bacteria
HZT45_RS02205	COG1215	transferase activity, transferring glycosyl groups
HZT45_RS02215	COG0531	amino acid
HZT45_RS02220	COG0494	nUDIX hydrolase
HZT45_RS02225	COG0028	Belongs to the TPP enzyme family
HZT45_RS02255	COG0457	Tetratricopeptide repeat
HZT45_RS02275	COG1914	H( )-stimulated, divalent metal cation uptake system
HZT45_RS02285	COG4876	unkown
HZT45_RS02295	COG2076	Multidrug Resistance protein
HZT45_RS02300	COG2217	Heavy metal translocating P-type atpase
HZT45_RS02305	COG3729	General stress protein
HZT45_RS02310	COG0662	Cupin 2, conserved barrel domain protein
HZT45_RS02315	COG2329	Antibiotic biosynthesis monooxygenase
HZT45_RS02320	COG3546	catalase activity
HZT45_RS02325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZT45_RS02330	COG3290	protein histidine kinase activity
HZT45_RS02335	COG4565	transcriptional regulatory protein
HZT45_RS02340	COG1301	dicarboxylic acid transport
HZT45_RS02345	COG0628	permease
HZT45_RS02350	COG1131	(ABC) transporter
HZT45_RS02355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZT45_RS02365	COG1960	acyl-CoA dehydrogenase activity
HZT45_RS02380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZT45_RS02385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS02395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZT45_RS02400	COG0513	Belongs to the DEAD box helicase family
HZT45_RS02405	COG3402	PFAM membrane-flanked domain
HZT45_RS02410	COG3428	Bacterial PH domain
HZT45_RS02415	COG0705	Rhomboid family
HZT45_RS02425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZT45_RS02430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZT45_RS02435	COG0864	Transcriptional regulator
HZT45_RS02440	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZT45_RS02445	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS02450	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS02455	COG2172	sigma factor antagonist activity
HZT45_RS02460	COG2208	phosphoserine phosphatase activity
HZT45_RS02465	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS02475	COG1191	sigma factor activity
HZT45_RS02480	COG2208	phosphoserine phosphatase activity
HZT45_RS02485	COG2183	response to ionizing radiation
HZT45_RS02540	COG5444	nuclease activity
HZT45_RS02545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS02545	COG0425	Belongs to the sulfur carrier protein TusA family
HZT45_RS02555	COG0477	Major facilitator Superfamily
HZT45_RS02560	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZT45_RS02580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZT45_RS02585	COG0477	Major facilitator Superfamily
HZT45_RS02590	COG1846	Transcriptional regulator
HZT45_RS02600	COG2030	dehydratase
HZT45_RS02610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZT45_RS02615	COG1959	2 iron, 2 sulfur cluster binding
HZT45_RS02620	COG2910	NAD(P)H-binding
HZT45_RS02625	COG1309	transcriptional regulator
HZT45_RS02630	COG0300	oxidoreductase activity
HZT45_RS02640	COG0604	alcohol dehydrogenase
HZT45_RS02650	COG3239	Fatty acid desaturase
HZT45_RS02660	COG1278	Cold shock
HZT45_RS02665	COG1329	Transcriptional regulator
HZT45_RS02670	COG1937	Protein conserved in bacteria
HZT45_RS02675	COG2210	Belongs to the sulfur carrier protein TusA family
HZT45_RS02685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS02685	COG0425	Belongs to the sulfur carrier protein TusA family
HZT45_RS02690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS02695	COG0425	Belongs to the sulfur carrier protein TusA family
HZT45_RS02700	COG0730	response to heat
HZT45_RS02705	COG1794	racemase activity, acting on amino acids and derivatives
HZT45_RS02720	COG0456	acetyltransferase
HZT45_RS02720	COG1846	Transcriptional regulator
HZT45_RS02725	COG2271	Major facilitator Superfamily
HZT45_RS02730	COG3621	Patatin-like phospholipase
HZT45_RS02740	COG0662	Cupin 2, conserved barrel domain protein
HZT45_RS02755	COG0277	FAD linked oxidase domain protein
HZT45_RS02780	COG0662	Cupin 2, conserved barrel domain protein
HZT45_RS02785	COG2318	DinB family
HZT45_RS02790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZT45_RS02825	COG0351	phosphomethylpyrimidine kinase
HZT45_RS02845	COG1064	alcohol dehydrogenase
HZT45_RS02850	COG0789	Transcriptional regulator
HZT45_RS02860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS02895	COG2814	Major facilitator Superfamily
HZT45_RS02900	COG1309	transcriptional regulator
HZT45_RS02905	COG0697	spore germination
HZT45_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS02915	COG5577	PFAM Coat F domain
HZT45_RS02925	COG1063	alcohol dehydrogenase
HZT45_RS02930	COG5577	PFAM Coat F domain
HZT45_RS02940	COG4585	Histidine kinase
HZT45_RS02945	COG2197	response regulator
HZT45_RS02950	COG2409	Drug exporters of the RND superfamily
HZT45_RS02965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT45_RS02970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS02980	COG2814	Major facilitator Superfamily
HZT45_RS02985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZT45_RS02995	COG0730	response to heat
HZT45_RS03000	COG0456	acetyltransferase
HZT45_RS03005	COG0789	Transcriptional regulator
HZT45_RS03005	COG4978	Transcriptional regulator
HZT45_RS03010	COG0697	spore germination
HZT45_RS03015	COG1051	belongs to the nudix hydrolase family
HZT45_RS03020	COG2226	methyltransferase
HZT45_RS03030	COG1802	Transcriptional regulator
HZT45_RS03035	COG1819	glycosyl
HZT45_RS03050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZT45_RS03060	COG1388	LysM domain
HZT45_RS03065	COG2814	Major facilitator Superfamily
HZT45_RS03070	COG2188	Transcriptional regulator
HZT45_RS03075	COG2186	Transcriptional regulator
HZT45_RS03080	COG2807	transmembrane transport
HZT45_RS03085	COG2076	Multidrug Resistance protein
HZT45_RS03090	COG2076	Multidrug Resistance protein
HZT45_RS03095	COG1309	transcriptional regulator
HZT45_RS03100	COG0531	amino acid
HZT45_RS03110	COG3832	glyoxalase III activity
HZT45_RS03115	COG0604	alcohol dehydrogenase
HZT45_RS03120	COG2814	Major facilitator Superfamily
HZT45_RS03160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZT45_RS03165	COG0802	atpase or kinase
HZT45_RS03170	COG1214	PFAM Peptidase M22, glycoprotease
HZT45_RS03175	COG0456	acetyltransferase
HZT45_RS03180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZT45_RS03185	COG0488	(ABC) transporter
HZT45_RS03200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZT45_RS03205	COG0805	protein transport
HZT45_RS03215	COG1266	CAAX protease self-immunity
HZT45_RS03235	COG1073	alpha beta
HZT45_RS03240	COG0457	Tetratricopeptide repeat
HZT45_RS03245	COG1063	alcohol dehydrogenase
HZT45_RS03250	COG2211	Major facilitator Superfamily
HZT45_RS03255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZT45_RS03265	COG1842	Phage shock protein A
HZT45_RS03270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZT45_RS03275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HZT45_RS03280	COG4260	virion core protein, lumpy skin disease virus
HZT45_RS03285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZT45_RS03285	COG2755	lipolytic protein G-D-S-L family
HZT45_RS03295	COG1595	DNA-templated transcription, initiation
HZT45_RS03300	COG1063	alcohol dehydrogenase
HZT45_RS03305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZT45_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
HZT45_RS03325	COG2132	Multicopper oxidase
HZT45_RS03330	COG1113	amino acid transport
HZT45_RS03335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZT45_RS03340	COG0714	Associated with various cellular activities
HZT45_RS03345	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HZT45_RS03350	COG1305	Transglutaminase-like
HZT45_RS03370	COG2252	PERMEase
HZT45_RS03375	COG3064	Membrane
HZT45_RS03395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZT45_RS03400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZT45_RS03405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZT45_RS03410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZT45_RS03415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZT45_RS03430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZT45_RS03440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZT45_RS03445	COG0138	bifunctional purine biosynthesis protein purh
HZT45_RS03450	COG0151	Belongs to the GarS family
HZT45_RS03460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZT45_RS03465	COG1470	cell adhesion involved in biofilm formation
HZT45_RS03470	COG4496	protein, YerC YecD
HZT45_RS03475	COG0069	glutamate synthase activity
HZT45_RS03485	COG0210	DNA helicase
HZT45_RS03495	COG4851	CamS sex pheromone cAM373 precursor
HZT45_RS03500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZT45_RS03510	COG1285	pathogenesis
HZT45_RS03515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT45_RS03535	COG1309	transcriptional regulator
HZT45_RS03540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZT45_RS03545	COG1597	lipid kinase activity
HZT45_RS03550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZT45_RS03560	COG1131	(ABC) transporter
HZT45_RS03580	COG5444	nuclease activity
HZT45_RS03590	COG5444	nuclease activity
HZT45_RS03615	COG3546	catalase activity
HZT45_RS03620	COG0454	-acetyltransferase
HZT45_RS03630	COG2323	membrane
HZT45_RS03635	COG2329	Antibiotic biosynthesis monooxygenase
HZT45_RS03640	COG0346	lactoylglutathione lyase activity
HZT45_RS03645	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS03650	COG5583	Uncharacterized small protein (DUF2292)
HZT45_RS03655	COG0196	riboflavin kinase activity
HZT45_RS03660	COG0670	Belongs to the BI1 family
HZT45_RS03665	COG1846	Transcriptional regulator
HZT45_RS03670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZT45_RS03680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZT45_RS03680	COG2124	cytochrome p450
HZT45_RS03685	COG1368	sulfuric ester hydrolase activity
HZT45_RS03690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZT45_RS03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS03700	COG1442	glycosyl transferase family 8
HZT45_RS03705	COG1216	Glycosyl transferase, family 2
HZT45_RS03710	COG1442	glycosyl transferase family 8
HZT45_RS03715	COG2223	nitrite transmembrane transporter activity
HZT45_RS03720	COG0531	amino acid
HZT45_RS03725	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS03730	COG0840	transmembrane signaling receptor activity
HZT45_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS03740	COG0457	Tetratricopeptide repeat
HZT45_RS03740	COG0463	Glycosyl transferase, family 2
HZT45_RS03745	COG0488	(ABC) transporter
HZT45_RS03750	COG0789	Transcriptional regulator
HZT45_RS03755	COG2814	Major facilitator Superfamily
HZT45_RS03760	COG0488	(ABC) transporter
HZT45_RS03765	COG0513	Belongs to the DEAD box helicase family
HZT45_RS03775	COG2130	NADP-dependent
HZT45_RS03790	COG3866	Pectate lyase
HZT45_RS03795	COG0471	metal ion transport
HZT45_RS03815	COG3290	protein histidine kinase activity
HZT45_RS03820	COG4565	transcriptional regulatory protein
HZT45_RS03825	COG3181	Tripartite tricarboxylate transporter family receptor
HZT45_RS03830	COG2851	Citrate transporter
HZT45_RS03835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS03840	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HZT45_RS03850	COG2258	MOSC domain
HZT45_RS03870	COG0024	Methionine aminopeptidase
HZT45_RS03875	COG1263	PTS System
HZT45_RS03875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS03885	COG1368	sulfuric ester hydrolase activity
HZT45_RS03895	COG0071	Belongs to the small heat shock protein (HSP20) family
HZT45_RS03910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS03910	COG1263	PTS System
HZT45_RS03915	COG0366	Alpha amylase catalytic
HZT45_RS03920	COG2188	Transcriptional regulator
HZT45_RS03925	COG0778	Nitroreductase
HZT45_RS03940	COG0737	Belongs to the 5'-nucleotidase family
HZT45_RS03945	COG0693	protein deglycase activity
HZT45_RS03950	COG1609	Transcriptional regulator
HZT45_RS03965	COG2814	Major facilitator Superfamily
HZT45_RS03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZT45_RS03980	COG4980	gas vesicle protein
HZT45_RS03985	COG1295	ribonuclease BN
HZT45_RS03990	COG0477	Major facilitator Superfamily
HZT45_RS03995	COG0387	Pfam Sodium calcium exchanger
HZT45_RS04005	COG0668	transmembrane transport
HZT45_RS04010	COG0535	radical SAM domain protein
HZT45_RS04020	COG0726	polysaccharide deacetylase
HZT45_RS04025	COG2084	Dehydrogenase
HZT45_RS04035	COG0598	Magnesium transport protein CorA
HZT45_RS04040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZT45_RS04045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZT45_RS04055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZT45_RS04060	COG4637	Psort location Cytoplasmic, score
HZT45_RS04065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZT45_RS04070	COG0022	dehydrogenase e1 component
HZT45_RS04075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZT45_RS04080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZT45_RS04085	COG3284	Transcriptional regulator
HZT45_RS04095	COG1486	melibiose metabolic process
HZT45_RS04100	COG1737	Transcriptional regulator
HZT45_RS04105	COG1263	PTS System
HZT45_RS04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS04110	COG5434	Belongs to the glycosyl hydrolase 28 family
HZT45_RS04115	COG1132	(ABC) transporter
HZT45_RS04120	COG1132	(ABC) transporter
HZT45_RS04125	COG2259	Doxx family
HZT45_RS04130	COG2514	catechol 2,3-dioxygenase activity
HZT45_RS04140	COG1695	Transcriptional regulator
HZT45_RS04145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZT45_RS04150	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HZT45_RS04155	COG3848	Pyruvate phosphate dikinase
HZT45_RS04155	COG0574	Belongs to the PEP-utilizing enzyme family
HZT45_RS04160	COG2732	(Barnase) inhibitor
HZT45_RS04165	COG2318	DinB family
HZT45_RS04170	COG2814	Major facilitator Superfamily
HZT45_RS04175	COG1846	Transcriptional regulator
HZT45_RS04180	COG0392	lysyltransferase activity
HZT45_RS04180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZT45_RS04185	COG0384	phenazine biosynthesis protein PhzF
HZT45_RS04190	COG0778	Nitroreductase
HZT45_RS04205	COG1090	epimerase
HZT45_RS04220	COG2814	Major facilitator Superfamily
HZT45_RS04230	COG3591	Belongs to the peptidase S1B family
HZT45_RS04245	COG3103	Sh3 type 3 domain protein
HZT45_RS04250	COG5658	integral membrane protein
HZT45_RS04255	COG0596	Alpha beta hydrolase
HZT45_RS04260	COG0463	Glycosyl transferase, family 2
HZT45_RS04265	COG4485	Bacterial membrane protein, YfhO
HZT45_RS04270	COG1988	membrane-bound metal-dependent
HZT45_RS04275	COG1194	a g-specific adenine glycosylase
HZT45_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS04305	COG1132	(ABC) transporter
HZT45_RS04310	COG4129	membrane
HZT45_RS04320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZT45_RS04325	COG0735	belongs to the Fur family
HZT45_RS04435	COG1757	Na H antiporter
HZT45_RS04440	COG3340	Belongs to the peptidase S51 family
HZT45_RS04450	COG0277	FAD linked oxidase domain protein
HZT45_RS04465	COG0753	catalase activity
HZT45_RS04475	COG1116	anion transmembrane transporter activity
HZT45_RS04480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZT45_RS04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZT45_RS04505	COG1476	TRANSCRIPTIONal
HZT45_RS04515	COG3382	B3 4 domain protein
HZT45_RS04520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZT45_RS04530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZT45_RS04535	COG0789	Transcriptional regulator
HZT45_RS04540	COG1664	Polymer-forming cytoskeletal
HZT45_RS04545	COG1664	Polymer-forming cytoskeletal
HZT45_RS04550	COG2766	serine protein kinase
HZT45_RS04560	COG1846	Transcriptional regulator
HZT45_RS04565	COG1566	PFAM secretion protein HlyD family protein
HZT45_RS04570	COG2814	Major facilitator Superfamily
HZT45_RS04575	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZT45_RS04590	COG1725	Transcriptional regulator
HZT45_RS04595	COG1131	(ABC) transporter
HZT45_RS04600	COG1131	(ABC) transporter
HZT45_RS04605	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZT45_RS04610	COG1278	Cold shock
HZT45_RS04615	COG1464	Belongs to the NlpA lipoprotein family
HZT45_RS04620	COG3706	GGDEF domain
HZT45_RS04625	COG1823	symporter activity
HZT45_RS04645	COG5577	PFAM Coat F domain
HZT45_RS04650	COG1525	nuclease
HZT45_RS04650	COG4085	toxin activity
HZT45_RS04650	COG0737	Belongs to the 5'-nucleotidase family
HZT45_RS04655	COG3764	Sortase (surface protein transpeptidase)
HZT45_RS04660	COG0564	pseudouridine synthase activity
HZT45_RS04670	COG0517	IMP dehydrogenase activity
HZT45_RS04675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZT45_RS04680	COG3153	acetyltransferase
HZT45_RS04680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZT45_RS04685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZT45_RS04690	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HZT45_RS04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZT45_RS04705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZT45_RS04710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZT45_RS04715	COG2203	Gaf domain
HZT45_RS04715	COG4585	Histidine kinase
HZT45_RS04720	COG2197	response regulator
HZT45_RS04725	COG0431	NADPH-dependent FMN reductase
HZT45_RS04740	COG1388	LysM domain
HZT45_RS04740	COG0791	NLP P60 protein
HZT45_RS04745	COG1959	2 iron, 2 sulfur cluster binding
HZT45_RS04750	COG0668	transmembrane transport
HZT45_RS04755	COG2719	SpoVR family
HZT45_RS04760	COG1785	Belongs to the alkaline phosphatase family
HZT45_RS04765	COG0791	NLP P60 protein
HZT45_RS04765	COG1388	LysM domain
HZT45_RS04770	COG0583	DNA-binding transcription factor activity
HZT45_RS04775	COG0372	Belongs to the citrate synthase family
HZT45_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS04785	COG0531	amino acid
HZT45_RS04790	COG0733	neurotransmitter:sodium symporter activity
HZT45_RS04805	COG1595	DNA-templated transcription, initiation
HZT45_RS04810	COG0204	Acyl-transferase
HZT45_RS04815	COG1253	flavin adenine dinucleotide binding
HZT45_RS04820	COG0789	Transcriptional regulator
HZT45_RS04825	COG0436	Aminotransferase
HZT45_RS04830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZT45_RS04835	COG1253	flavin adenine dinucleotide binding
HZT45_RS04840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZT45_RS04845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZT45_RS04850	COG0584	glycerophosphoryl diester phosphodiesterase
HZT45_RS04860	COG0668	transmembrane transport
HZT45_RS04865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZT45_RS04870	COG0726	polysaccharide deacetylase
HZT45_RS04875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS04880	COG3226	Transcriptional regulator
HZT45_RS04890	COG0589	response to stress
HZT45_RS04895	COG1132	(ABC) transporter
HZT45_RS04900	COG1132	(ABC) transporter
HZT45_RS04905	COG0702	epimerase
HZT45_RS04920	COG0189	ligase activity
HZT45_RS04925	COG0189	ligase activity
HZT45_RS04940	COG4335	DNA alkylation repair
HZT45_RS04945	COG0561	phosphatase activity
HZT45_RS04950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZT45_RS04960	COG0475	glutathione-regulated potassium exporter activity
HZT45_RS04965	COG0490	domain, Protein
HZT45_RS04975	COG1024	Enoyl-CoA hydratase
HZT45_RS04985	COG4152	abc transporter atp-binding protein
HZT45_RS04990	COG1668	transmembrane transport
HZT45_RS04995	COG0420	3'-5' exonuclease activity
HZT45_RS05000	COG4717	serine-type aminopeptidase activity
HZT45_RS05015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZT45_RS05050	COG4980	gas vesicle protein
HZT45_RS05065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZT45_RS05070	COG0537	adenosine 5'-monophosphoramidase activity
HZT45_RS05075	COG1131	(ABC) transporter
HZT45_RS05080	COG4473	ABC transporter
HZT45_RS05090	COG1473	amidohydrolase
HZT45_RS05095	COG3069	C4-dicarboxylate transmembrane transporter activity
HZT45_RS05100	COG2329	Antibiotic biosynthesis monooxygenase
HZT45_RS05105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT45_RS05125	COG1309	transcriptional regulator
HZT45_RS05130	COG1511	domain protein
HZT45_RS05135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZT45_RS05145	COG1363	Peptidase, m42
HZT45_RS05150	COG1301	dicarboxylic acid transport
HZT45_RS05160	COG1234	tRNA 3'-trailer cleavage
HZT45_RS05165	COG0095	Lipoate-protein ligase
HZT45_RS05170	COG0702	epimerase
HZT45_RS05175	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS05185	COG0501	Belongs to the peptidase M48B family
HZT45_RS05190	COG1404	Belongs to the peptidase S8 family
HZT45_RS05195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HZT45_RS05200	COG0406	alpha-ribazole phosphatase activity
HZT45_RS05205	COG0183	Belongs to the thiolase family
HZT45_RS05210	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS05215	COG1268	BioY protein
HZT45_RS05220	COG0840	transmembrane signaling receptor activity
HZT45_RS05225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT45_RS05225	COG0723	plastoquinol--plastocyanin reductase activity
HZT45_RS05230	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS05240	COG4903	ComK protein
HZT45_RS05250	COG5646	InterPro IPR014922
HZT45_RS05275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT45_RS05290	COG0398	Pfam SNARE associated Golgi protein
HZT45_RS05295	COG0681	Belongs to the peptidase S26 family
HZT45_RS05300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZT45_RS05305	COG1846	Transcriptional regulator
HZT45_RS05310	COG3180	Ammonia monooxygenase
HZT45_RS05315	COG2814	Major facilitator Superfamily
HZT45_RS05325	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HZT45_RS05330	COG2323	membrane
HZT45_RS05345	COG0420	3'-5' exonuclease activity
HZT45_RS05350	COG0419	ATPase involved in DNA repair
HZT45_RS05355	COG1403	HNH endonuclease
HZT45_RS05395	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZT45_RS05410	COG0367	asparagine synthase
HZT45_RS05415	COG1562	ergosterol biosynthetic process
HZT45_RS05420	COG0534	Mate efflux family protein
HZT45_RS05425	COG2207	Transcriptional regulator
HZT45_RS05425	COG1917	Cupin 2, conserved barrel domain protein
HZT45_RS05430	COG2318	DinB family
HZT45_RS05435	COG1279	arginine transmembrane transporter activity
HZT45_RS05440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS05445	COG1357	PFAM Pentapeptide repeats (8 copies)
HZT45_RS05450	COG2153	protein acetylation
HZT45_RS05455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZT45_RS05455	COG0646	methionine synthase
HZT45_RS05465	COG2996	Protein conserved in bacteria
HZT45_RS05475	COG0840	transmembrane signaling receptor activity
HZT45_RS05480	COG2124	cytochrome p450
HZT45_RS05490	COG1307	EDD domain protein, DegV family
HZT45_RS05495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS05515	COG0561	phosphatase activity
HZT45_RS05520	COG1073	alpha beta
HZT45_RS05525	COG2151	metal-sulfur cluster biosynthetic enzyme
HZT45_RS05535	COG0277	FAD linked oxidase domain protein
HZT45_RS05540	COG2271	Major facilitator Superfamily
HZT45_RS05550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZT45_RS05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZT45_RS05565	COG0505	Belongs to the CarA family
HZT45_RS05570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZT45_RS05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZT45_RS05590	COG2267	carboxylic ester hydrolase activity
HZT45_RS05600	COG1744	ABC transporter substrate-binding protein PnrA-like
HZT45_RS05615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZT45_RS05620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZT45_RS05625	COG5504	Zn-dependent protease
HZT45_RS05630	COG0444	Belongs to the ABC transporter superfamily
HZT45_RS05635	COG4608	Belongs to the ABC transporter superfamily
HZT45_RS05645	COG0601	transmembrane transport
HZT45_RS05650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZT45_RS05660	COG0180	Tryptophanyl-tRNA synthetase
HZT45_RS05665	COG4166	transmembrane transport
HZT45_RS05670	COG0601	transmembrane transport
HZT45_RS05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZT45_RS05680	COG0444	Belongs to the ABC transporter superfamily
HZT45_RS05685	COG4608	Belongs to the ABC transporter superfamily
HZT45_RS05695	COG0456	acetyltransferase
HZT45_RS05700	COG1393	Belongs to the ArsC family
HZT45_RS05705	COG0861	Integral membrane protein TerC family
HZT45_RS05715	COG4862	establishment of competence for transformation
HZT45_RS05720	COG4469	Competence protein
HZT45_RS05725	COG1164	Oligoendopeptidase f
HZT45_RS05740	COG2346	COG2346, Truncated hemoglobins
HZT45_RS05745	COG0741	lytic transglycosylase activity
HZT45_RS05750	COG4116	CYTH
HZT45_RS05760	COG2357	RelA SpoT domain protein
HZT45_RS05765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZT45_RS05770	COG0564	pseudouridine synthase activity
HZT45_RS05780	COG0475	glutathione-regulated potassium exporter activity
HZT45_RS05780	COG0569	domain protein
HZT45_RS05785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HZT45_RS05790	COG0352	thiamine-phosphate diphosphorylase activity
HZT45_RS05795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT45_RS05800	COG2104	thiamine diphosphate biosynthetic process
HZT45_RS05810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZT45_RS05815	COG0351	phosphomethylpyrimidine kinase
HZT45_RS05820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZT45_RS05875	COG0210	DNA helicase
HZT45_RS05895	COG1131	(ABC) transporter
HZT45_RS05905	COG2153	protein acetylation
HZT45_RS05915	COG2382	esterase
HZT45_RS05920	COG0626	cystathionine gamma-synthase activity
HZT45_RS05925	COG0626	cystathionine gamma-synthase activity
HZT45_RS05940	COG5444	nuclease activity
HZT45_RS06000	COG2367	Beta-lactamase
HZT45_RS06005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HZT45_RS06025	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZT45_RS06030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZT45_RS06035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZT45_RS06040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS06040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS06045	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZT45_RS06075	COG1285	pathogenesis
HZT45_RS06090	COG2205	protein histidine kinase activity
HZT45_RS06100	COG3383	formate dehydrogenase (NAD+) activity
HZT45_RS06105	COG2427	Protein of unknown function (DUF1641)
HZT45_RS06110	COG2124	cytochrome p450
HZT45_RS06115	COG1819	glycosyl
HZT45_RS06125	COG1587	Uroporphyrinogen-III synthase
HZT45_RS06130	COG0390	transport system, permease component
HZT45_RS06135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZT45_RS06140	COG0697	spore germination
HZT45_RS06145	COG4297	protein containing double-stranded beta helix domain
HZT45_RS06155	COG1252	NADH dehydrogenase
HZT45_RS06165	COG2211	Major facilitator Superfamily
HZT45_RS06170	COG1609	Transcriptional regulator
HZT45_RS06175	COG0246	Mannitol dehydrogenase
HZT45_RS06180	COG2721	sulfolactate sulfo-lyase activity
HZT45_RS06185	COG0730	response to heat
HZT45_RS06190	COG2318	DinB family
HZT45_RS06195	COG0457	Tetratricopeptide repeat
HZT45_RS06205	COG1388	LysM domain
HZT45_RS06205	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS06205	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS06215	COG4195	phage-related replication protein
HZT45_RS06220	COG2856	Zn peptidase
HZT45_RS06225	COG1396	sequence-specific DNA binding
HZT45_RS06235	COG1522	sequence-specific DNA binding
HZT45_RS06240	COG1484	DNA-dependent DNA replication
HZT45_RS06260	COG1595	DNA-templated transcription, initiation
HZT45_RS06265	COG5484	DNA packaging
HZT45_RS06265	COG3728	DNA packaging
HZT45_RS06270	COG1783	phage Terminase large subunit
HZT45_RS06275	COG5518	Phage portal protein
HZT45_RS06280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HZT45_RS06285	COG4653	Phage capsid family
HZT45_RS06335	COG5412	phage tail tape measure protein
HZT45_RS06335	COG5412	phage tail tape measure protein
HZT45_RS06335	COG3953	SLT domain
HZT45_RS06335	COG3953	SLT domain
HZT45_RS06335	COG5412	phage tail tape measure protein
HZT45_RS06335	COG3953	SLT domain
HZT45_RS06340	COG1652	LysM domain
HZT45_RS06345	COG4193	domain, Protein
HZT45_RS06355	COG3628	GPW Gp25 family protein
HZT45_RS06360	COG3299	homolog of phage Mu protein gp47
HZT45_RS06365	COG3778	Protein conserved in bacteria
HZT45_RS06405	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS06405	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS06420	COG0306	phosphate transporter
HZT45_RS06425	COG1392	Phosphate transport regulator
HZT45_RS06430	COG0531	amino acid
HZT45_RS06435	COG0346	lactoylglutathione lyase activity
HZT45_RS06440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZT45_RS06445	COG0463	Glycosyl transferase, family 2
HZT45_RS06460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT45_RS06465	COG0477	Major facilitator Superfamily
HZT45_RS06470	COG2362	D-Aminopeptidase
HZT45_RS06475	COG0601	transmembrane transport
HZT45_RS06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZT45_RS06485	COG0444	Belongs to the ABC transporter superfamily
HZT45_RS06490	COG4166	transmembrane transport
HZT45_RS06495	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZT45_RS06500	COG4948	Mandelate Racemase Muconate Lactonizing
HZT45_RS06505	COG0791	NLP P60 protein
HZT45_RS06510	COG4608	Belongs to the ABC transporter superfamily
HZT45_RS06515	COG2706	6-phosphogluconolactonase activity
HZT45_RS06520	COG1834	amidinotransferase
HZT45_RS06525	COG1607	acyl-coa hydrolase
HZT45_RS06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT45_RS06535	COG2076	Multidrug Resistance protein
HZT45_RS06540	COG2076	Multidrug Resistance protein
HZT45_RS06545	COG0788	formyltetrahydrofolate deformylase activity
HZT45_RS06550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZT45_RS06560	COG1764	response to oxidative stress
HZT45_RS06565	COG1846	Transcriptional regulator
HZT45_RS06570	COG1764	response to oxidative stress
HZT45_RS06585	COG0463	Glycosyl transferase, family 2
HZT45_RS06585	COG0457	Tetratricopeptide repeat
HZT45_RS06595	COG2814	Major facilitator Superfamily
HZT45_RS06600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT45_RS06610	COG1404	Belongs to the peptidase S8 family
HZT45_RS06615	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS06620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZT45_RS06625	COG1122	ATPase activity
HZT45_RS06630	COG4721	ABC-type cobalt transport system, permease component
HZT45_RS06635	COG3858	chitin binding
HZT45_RS06635	COG1388	LysM domain
HZT45_RS06645	COG2239	Acts as a magnesium transporter
HZT45_RS06650	COG0789	Transcriptional regulator
HZT45_RS06665	COG1846	Transcriptional regulator
HZT45_RS06670	COG0726	polysaccharide deacetylase
HZT45_RS06675	COG1793	dna ligase
HZT45_RS06675	COG3285	dna ligase
HZT45_RS06680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZT45_RS06685	COG0586	Pfam SNARE associated Golgi protein
HZT45_RS06690	COG0861	Integral membrane protein TerC family
HZT45_RS06695	COG1191	sigma factor activity
HZT45_RS06720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZT45_RS06725	COG2323	membrane
HZT45_RS06735	COG3594	Acyltransferase
HZT45_RS06740	COG5002	protein histidine kinase activity
HZT45_RS06745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZT45_RS06760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZT45_RS06765	COG0436	Aminotransferase
HZT45_RS06795	COG3852	Histidine kinase
HZT45_RS06800	COG1846	Transcriptional regulator
HZT45_RS06805	COG1360	Flagellar Motor Protein
HZT45_RS06810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZT45_RS06815	COG0542	response to heat
HZT45_RS06820	COG3949	Membrane
HZT45_RS06835	COG0720	synthase
HZT45_RS06840	COG0602	queuosine metabolic process
HZT45_RS06855	COG1733	regulation of RNA biosynthetic process
HZT45_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS06875	COG4873	Protein conserved in bacteria
HZT45_RS06885	COG3773	Cell wall hydrolase
HZT45_RS06890	COG2244	polysaccharide biosynthetic process
HZT45_RS06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS06900	COG2217	Heavy metal translocating P-type atpase
HZT45_RS06905	COG0006	proline dipeptidase activity
HZT45_RS06910	COG1609	Transcriptional regulator
HZT45_RS06915	COG3711	transcriptional antiterminator
HZT45_RS06920	COG1263	PTS System
HZT45_RS06920	COG2190	(PTS) system
HZT45_RS06920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS06925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS06930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZT45_RS06940	COG1533	DNA photolyase activity
HZT45_RS06945	COG0840	transmembrane signaling receptor activity
HZT45_RS06950	COG2084	Dehydrogenase
HZT45_RS06955	COG2340	Cysteine-rich secretory protein family
HZT45_RS06960	COG0768	penicillin binding
HZT45_RS06965	COG4191	Histidine kinase
HZT45_RS06970	COG0436	Aminotransferase
HZT45_RS06980	COG0835	chemotaxis
HZT45_RS06980	COG0784	Response regulator, receiver
HZT45_RS06990	COG2814	Major facilitator Superfamily
HZT45_RS06995	COG1376	ErfK ybiS ycfS ynhG family protein
HZT45_RS07000	COG1408	metallophosphoesterase
HZT45_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS07015	COG2200	EAL domain
HZT45_RS07020	COG4703	Protein of unknown function (DUF1797)
HZT45_RS07025	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HZT45_RS07035	COG0517	IMP dehydrogenase activity
HZT45_RS07040	COG0583	DNA-binding transcription factor activity
HZT45_RS07045	COG0716	FMN binding
HZT45_RS07055	COG0716	FMN binding
HZT45_RS07075	COG0668	transmembrane transport
HZT45_RS07080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS07100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZT45_RS07105	COG0303	'Molybdopterin
HZT45_RS07110	COG1763	Mo-molybdopterin cofactor biosynthetic process
HZT45_RS07115	COG0314	molybdopterin synthase activity
HZT45_RS07120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZT45_RS07130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZT45_RS07135	COG1136	(ABC) transporter
HZT45_RS07140	COG0577	efflux transmembrane transporter activity
HZT45_RS07145	COG1349	DNA-binding transcription factor activity
HZT45_RS07150	COG1105	Belongs to the carbohydrate kinase PfkB family
HZT45_RS07155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZT45_RS07155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZT45_RS07155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS07160	COG0681	Belongs to the peptidase S26 family
HZT45_RS07170	COG0488	(ABC) transporter
HZT45_RS07175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZT45_RS07180	COG2309	aminopeptidase activity
HZT45_RS07190	COG1077	Cell shape determining protein MreB Mrl
HZT45_RS07195	COG2002	toxin-antitoxin pair type II binding
HZT45_RS07200	COG3852	Histidine kinase
HZT45_RS07205	COG2105	PFAM AIG2 family protein
HZT45_RS07205	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HZT45_RS07210	COG0569	domain protein
HZT45_RS07220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZT45_RS07230	COG0561	phosphatase activity
HZT45_RS07235	COG0242	peptide deformylase activity
HZT45_RS07245	COG0497	DNA recombination
HZT45_RS07255	COG4221	oxidoreductase activity
HZT45_RS07255	COG3321	synthase
HZT45_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS07255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS07260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS07260	COG0300	oxidoreductase activity
HZT45_RS07260	COG3321	synthase
HZT45_RS07260	COG4221	oxidoreductase activity
HZT45_RS07265	COG4221	oxidoreductase activity
HZT45_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS07265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS07265	COG3321	synthase
HZT45_RS07270	COG0300	oxidoreductase activity
HZT45_RS07270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS07270	COG4221	oxidoreductase activity
HZT45_RS07270	COG3321	synthase
HZT45_RS07275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS07275	COG3321	synthase
HZT45_RS07275	COG0300	oxidoreductase activity
HZT45_RS07275	COG4221	oxidoreductase activity
HZT45_RS07280	COG0300	oxidoreductase activity
HZT45_RS07280	COG3321	synthase
HZT45_RS07280	COG4221	oxidoreductase activity
HZT45_RS07280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS07285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS07285	COG3321	synthase
HZT45_RS07285	COG4221	oxidoreductase activity
HZT45_RS07290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZT45_RS07295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZT45_RS07300	COG0022	dehydrogenase e1 component
HZT45_RS07305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZT45_RS07310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZT45_RS07315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS07330	COG1982	Orn Lys Arg decarboxylase major
HZT45_RS07350	COG0483	inositol monophosphate 1-phosphatase activity
HZT45_RS07360	COG3227	Zinc metalloprotease (Elastase)
HZT45_RS07375	COG1595	DNA-templated transcription, initiation
HZT45_RS07405	COG4896	Protein conserved in bacteria
HZT45_RS07415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZT45_RS07420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZT45_RS07425	COG2066	Belongs to the glutaminase family
HZT45_RS07435	COG0772	Belongs to the SEDS family
HZT45_RS07440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZT45_RS07455	COG2010	Cytochrome c
HZT45_RS07455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZT45_RS07460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZT45_RS07465	COG1845	cytochrome c oxidase, subunit III
HZT45_RS07470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZT45_RS07475	COG3336	cytochrome c oxidase
HZT45_RS07485	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HZT45_RS07490	COG2340	Cysteine-rich secretory protein family
HZT45_RS07505	COG3679	Belongs to the UPF0342 family
HZT45_RS07515	COG0742	ribosomal rna small subunit methyltransferase
HZT45_RS07525	COG3314	Sporulation integral membrane protein YlbJ
HZT45_RS07530	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZT45_RS07535	COG3480	Lon protease (S16) C-terminal proteolytic domain
HZT45_RS07545	COG1399	metal-binding, possibly nucleic acid-binding protein
HZT45_RS07565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZT45_RS07585	COG4839	cell division protein FtsL
HZT45_RS07595	COG0768	penicillin binding
HZT45_RS07615	COG0772	Belongs to the SEDS family
HZT45_RS07630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZT45_RS07635	COG0849	cell division
HZT45_RS07640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZT45_RS07645	COG4412	M6 family metalloprotease domain protein
HZT45_RS07645	COG1404	Belongs to the peptidase S8 family
HZT45_RS07655	COG1191	sigma factor activity
HZT45_RS07660	COG1191	sigma factor activity
HZT45_RS07665	COG1119	ATPase activity
HZT45_RS07670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZT45_RS07675	COG1873	PFAM PRC-barrel domain
HZT45_RS07685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZT45_RS07695	COG0762	integral membrane protein
HZT45_RS07700	COG2302	S4 RNA-binding domain
HZT45_RS07705	COG3599	regulation of cell shape
HZT45_RS07710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZT45_RS07715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZT45_RS07725	COG0564	pseudouridine synthase activity
HZT45_RS07735	COG2233	PERMEase
HZT45_RS07745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZT45_RS07750	COG0505	Belongs to the CarA family
HZT45_RS07755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZT45_RS07770	COG0284	orotidine-5'-phosphate decarboxylase activity
HZT45_RS07775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZT45_RS07785	COG0306	phosphate transporter
HZT45_RS07800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZT45_RS07805	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HZT45_RS07810	COG1648	precorrin-2 dehydrogenase activity
HZT45_RS07820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZT45_RS07825	COG1561	YicC-like family, N-terminal region
HZT45_RS07835	COG0194	GDP metabolic process
HZT45_RS07845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZT45_RS07850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZT45_RS07855	COG0242	peptide deformylase activity
HZT45_RS07865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZT45_RS07865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZT45_RS07875	COG0631	protein serine/threonine phosphatase activity
HZT45_RS07880	COG2815	serine threonine protein kinase
HZT45_RS07880	COG0515	serine threonine protein kinase
HZT45_RS07890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZT45_RS07895	COG1564	THIamine pyrophosphokinase
HZT45_RS07910	COG1302	Protein conserved in bacteria
HZT45_RS07915	COG1461	Dihydroxyacetone kinase
HZT45_RS07920	COG1760	l-serine dehydratase
HZT45_RS07925	COG1760	l-serine dehydratase
HZT45_RS07930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZT45_RS07945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZT45_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS07965	COG1196	nuclear chromosome segregation
HZT45_RS07970	COG0552	protein localization to endoplasmic reticulum
HZT45_RS07985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZT45_RS07995	COG1837	Belongs to the UPF0109 family
HZT45_RS08020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZT45_RS08035	COG2257	FlhB HrpN YscU SpaS Family
HZT45_RS08045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZT45_RS08050	COG0758	DNA mediated transformation
HZT45_RS08055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZT45_RS08065	COG4974	Belongs to the 'phage' integrase family
HZT45_RS08085	COG1815	bacterial-type flagellum-dependent cell motility
HZT45_RS08090	COG1558	bacterial-type flagellum-dependent cell motility
HZT45_RS08095	COG1677	Flagellar hook-basal body complex protein FliE
HZT45_RS08100	COG1766	The M ring may be actively involved in energy transduction
HZT45_RS08105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZT45_RS08110	COG1317	bacterial-type flagellum organization
HZT45_RS08115	COG1157	protein secretion by the type III secretion system
HZT45_RS08120	COG2882	bacterial-type flagellum organization
HZT45_RS08125	COG3334	PFAM MgtE intracellular
HZT45_RS08130	COG3144	bacterial-type flagellum assembly
HZT45_RS08135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZT45_RS08140	COG4786	Flagellar basal body rod
HZT45_RS08145	COG1582	Flagellar protein (FlbD)
HZT45_RS08150	COG1580	Controls the rotational direction of flagella during chemotaxis
HZT45_RS08155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZT45_RS08160	COG1776	CheC inhibitor of MCP methylation
HZT45_RS08160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZT45_RS08165	COG2201	protein-glutamate methylesterase activity
HZT45_RS08170	COG3190	flagellar
HZT45_RS08175	COG1338	Plays a role in the flagellum-specific transport system
HZT45_RS08180	COG1987	bacterial-type flagellum assembly
HZT45_RS08185	COG1684	flagellar biosynthetic protein fliR
HZT45_RS08190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZT45_RS08195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZT45_RS08200	COG1419	protein localization to endoplasmic reticulum
HZT45_RS08205	COG0455	bacterial-type flagellum organization
HZT45_RS08210	COG2201	protein-glutamate methylesterase activity
HZT45_RS08215	COG0643	Histidine kinase
HZT45_RS08215	COG2198	Histidine kinase
HZT45_RS08220	COG0835	chemotaxis
HZT45_RS08225	COG1776	CheC inhibitor of MCP methylation
HZT45_RS08235	COG1191	sigma factor activity
HZT45_RS08265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZT45_RS08270	COG4589	Belongs to the CDS family
HZT45_RS08280	COG0750	zinc metalloprotease
HZT45_RS08290	COG2176	DNA-directed DNA polymerase activity
HZT45_RS08300	COG0195	Participates in both transcription termination and antitermination
HZT45_RS08305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HZT45_RS08310	COG1358	cellular component organization or biogenesis
HZT45_RS08320	COG1550	Protein conserved in bacteria
HZT45_RS08335	COG0196	riboflavin kinase activity
HZT45_RS08350	COG0726	polysaccharide deacetylase
HZT45_RS08355	COG0612	Peptidase, M16
HZT45_RS08360	COG1873	PFAM PRC-barrel domain
HZT45_RS08365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZT45_RS08370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZT45_RS08375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZT45_RS08380	COG0527	aspartate kinase activity
HZT45_RS08390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZT45_RS08395	COG0740	serine-type endopeptidase activity
HZT45_RS08405	COG1674	ftsk spoiiie
HZT45_RS08405	COG4980	gas vesicle protein
HZT45_RS08410	COG2188	Transcriptional regulator
HZT45_RS08415	COG2814	Major facilitator Superfamily
HZT45_RS08420	COG1846	Transcriptional regulator
HZT45_RS08425	COG2409	Drug exporters of the RND superfamily
HZT45_RS08425	COG1033	growth of symbiont in host cell
HZT45_RS08430	COG0612	Peptidase, M16
HZT45_RS08435	COG0612	Peptidase, M16
HZT45_RS08440	COG0300	oxidoreductase activity
HZT45_RS08455	COG1426	Protein conserved in bacteria
HZT45_RS08460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZT45_RS08475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZT45_RS08485	COG1692	metallophosphoesterase
HZT45_RS08490	COG2359	stage V sporulation protein S
HZT45_RS08510	COG4550	Control of competence regulator ComK, YlbF/YmcA
HZT45_RS08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS08560	COG3425	synthase
HZT45_RS08565	COG1024	Enoyl-CoA hydratase
HZT45_RS08570	COG1024	Enoyl-CoA hydratase
HZT45_RS08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS08575	COG0300	oxidoreductase activity
HZT45_RS08575	COG3321	synthase
HZT45_RS08575	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS08580	COG4221	oxidoreductase activity
HZT45_RS08580	COG0300	oxidoreductase activity
HZT45_RS08580	COG3321	synthase
HZT45_RS08580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS08585	COG3321	synthase
HZT45_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS08585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS08585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS08585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS08585	COG3321	synthase
HZT45_RS08585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS08585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS08585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS08590	COG3321	synthase
HZT45_RS08590	COG4221	oxidoreductase activity
HZT45_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS08590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS08595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HZT45_RS08595	COG3321	synthase
HZT45_RS08595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZT45_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS08600	COG2124	cytochrome p450
HZT45_RS08605	COG3209	COG3209 Rhs family protein
HZT45_RS08610	COG3619	membrane
HZT45_RS08625	COG1404	Belongs to the peptidase S8 family
HZT45_RS08635	COG4195	phage-related replication protein
HZT45_RS08640	COG1764	response to oxidative stress
HZT45_RS08650	COG2076	Multidrug Resistance protein
HZT45_RS08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZT45_RS08695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZT45_RS08700	COG4112	unkown
HZT45_RS08705	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS08710	COG0464	growth
HZT45_RS08715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZT45_RS08720	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HZT45_RS08725	COG0789	Transcriptional regulator
HZT45_RS08730	COG0174	glutamine synthetase
HZT45_RS08740	COG2211	Major facilitator Superfamily
HZT45_RS08760	COG1070	Carbohydrate kinase
HZT45_RS08765	COG3848	Pyruvate phosphate dikinase
HZT45_RS08765	COG0574	Belongs to the PEP-utilizing enzyme family
HZT45_RS08785	COG2378	regulation of single-species biofilm formation
HZT45_RS08790	COG2318	DinB family
HZT45_RS08795	COG1064	alcohol dehydrogenase
HZT45_RS08815	COG0456	acetyltransferase
HZT45_RS08850	COG3397	chitin binding
HZT45_RS08870	COG5434	Belongs to the glycosyl hydrolase 28 family
HZT45_RS08875	COG0756	dUTP diphosphatase activity
HZT45_RS08885	COG4195	phage-related replication protein
HZT45_RS08920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZT45_RS08930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZT45_RS08950	COG0785	Cytochrome C biogenesis protein
HZT45_RS08955	COG2201	protein-glutamate methylesterase activity
HZT45_RS08960	COG4846	Membrane protein involved in cytochrome C biogenesis
HZT45_RS08970	COG0071	Belongs to the small heat shock protein (HSP20) family
HZT45_RS08985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZT45_RS08990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS09010	COG0824	Thioesterase
HZT45_RS09020	COG4841	protein insertion into membrane
HZT45_RS09030	COG1832	CoA-binding protein
HZT45_RS09035	COG0187	DNA topoisomerase II activity
HZT45_RS09040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZT45_RS09050	COG1115	amino acid carrier protein
HZT45_RS09060	COG1063	alcohol dehydrogenase
HZT45_RS09065	COG0800	Aldolase
HZT45_RS09070	COG1312	Catalyzes the dehydration of D-mannonate
HZT45_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS09080	COG1609	Transcriptional regulator
HZT45_RS09085	COG2271	Major facilitator Superfamily
HZT45_RS09110	COG1136	(ABC) transporter
HZT45_RS09110	COG0577	efflux transmembrane transporter activity
HZT45_RS09140	COG2205	protein histidine kinase activity
HZT45_RS09145	COG0745	RESPONSE REGULATOR receiver
HZT45_RS09155	COG3507	Belongs to the glycosyl hydrolase 43 family
HZT45_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS09185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZT45_RS09190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZT45_RS09195	COG2610	gluconate transmembrane transporter activity
HZT45_RS09200	COG2124	cytochrome p450
HZT45_RS09220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZT45_RS09230	COG2246	polysaccharide biosynthetic process
HZT45_RS09235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZT45_RS09240	COG0586	Pfam SNARE associated Golgi protein
HZT45_RS09245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZT45_RS09250	COG1024	Enoyl-CoA hydratase
HZT45_RS09255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZT45_RS09260	COG0511	ligase activity, forming carbon-carbon bonds
HZT45_RS09265	COG0439	Biotin carboxylase
HZT45_RS09270	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS09275	COG1960	acyl-CoA dehydrogenase activity
HZT45_RS09280	COG1649	PFAM Uncharacterised BCR, COG1649
HZT45_RS09290	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HZT45_RS09290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS09295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS09305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS09315	COG2027	D-alanyl-D-alanine carboxypeptidase
HZT45_RS09320	COG2017	converts alpha-aldose to the beta-anomer
HZT45_RS09325	COG0534	Mate efflux family protein
HZT45_RS09340	COG0582	viral genome integration into host DNA
HZT45_RS09345	COG0166	Belongs to the GPI family
HZT45_RS09350	COG0405	Gamma-glutamyltransferase
HZT45_RS09355	COG2814	Major facilitator Superfamily
HZT45_RS09360	COG0640	Transcriptional regulator
HZT45_RS09365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZT45_RS09375	COG0604	alcohol dehydrogenase
HZT45_RS09380	COG0493	'glutamate synthase
HZT45_RS09385	COG0067	glutamate synthase
HZT45_RS09385	COG0070	glutamate synthase
HZT45_RS09385	COG0069	glutamate synthase activity
HZT45_RS09390	COG0583	DNA-binding transcription factor activity
HZT45_RS09395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZT45_RS09430	COG0300	oxidoreductase activity
HZT45_RS09435	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HZT45_RS09445	COG2814	Major facilitator Superfamily
HZT45_RS09450	COG1070	Carbohydrate kinase
HZT45_RS09455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZT45_RS09460	COG0243	molybdopterin cofactor binding
HZT45_RS09495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT45_RS09500	COG2207	Transcriptional regulator
HZT45_RS09500	COG0662	Cupin 2, conserved barrel domain protein
HZT45_RS09505	COG1309	transcriptional regulator
HZT45_RS09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS09520	COG0640	Transcriptional regulator
HZT45_RS09525	COG0741	lytic transglycosylase activity
HZT45_RS09530	COG2322	membrane
HZT45_RS09545	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZT45_RS09555	COG1388	LysM domain
HZT45_RS09555	COG3584	3D domain protein
HZT45_RS09560	COG0514	ATP-dependent DNA helicase (RecQ)
HZT45_RS09570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZT45_RS09575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZT45_RS09590	COG0071	Belongs to the small heat shock protein (HSP20) family
HZT45_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS09625	COG1657	PFAM Prenyltransferase squalene oxidase
HZT45_RS09630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZT45_RS09635	COG0733	neurotransmitter:sodium symporter activity
HZT45_RS09640	COG0385	Bile acid
HZT45_RS09645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS09650	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZT45_RS09660	COG4548	von Willebrand factor, type A
HZT45_RS09665	COG0714	Associated with various cellular activities
HZT45_RS09670	COG2032	superoxide dismutase activity
HZT45_RS09675	COG0791	NLP P60 protein
HZT45_RS09675	COG1388	LysM domain
HZT45_RS09680	COG1819	glycosyl
HZT45_RS09685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZT45_RS09690	COG0534	Mate efflux family protein
HZT45_RS09695	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS09700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZT45_RS09705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZT45_RS09715	COG2962	Rard protein
HZT45_RS09730	COG1942	4-Oxalocrotonate Tautomerase
HZT45_RS09740	COG1733	regulation of RNA biosynthetic process
HZT45_RS09745	COG0778	Nitroreductase
HZT45_RS09750	COG0400	carboxylic ester hydrolase activity
HZT45_RS09755	COG0346	lactoylglutathione lyase activity
HZT45_RS09765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZT45_RS09775	COG2723	6-phospho-beta-galactosidase activity
HZT45_RS09780	COG2188	Transcriptional regulator
HZT45_RS09785	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS09785	COG0793	Belongs to the peptidase S41A family
HZT45_RS09790	COG2226	methyltransferase
HZT45_RS09800	COG1876	peptidase activity
HZT45_RS09820	COG0671	phosphoesterase, PA-phosphatase related
HZT45_RS09855	COG1509	lysine 2,3-aminomutase activity
HZT45_RS09860	COG0456	acetyltransferase
HZT45_RS09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZT45_RS09870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZT45_RS09875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZT45_RS09880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZT45_RS09895	COG0456	acetyltransferase
HZT45_RS09900	COG0463	Glycosyl transferase, family 2
HZT45_RS09915	COG4641	Protein conserved in bacteria
HZT45_RS09925	COG1086	Polysaccharide biosynthesis protein
HZT45_RS09945	COG1388	LysM domain
HZT45_RS09950	COG0457	Tetratricopeptide repeat
HZT45_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS09965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS09970	COG1252	NADH dehydrogenase
HZT45_RS09975	COG2197	response regulator
HZT45_RS09980	COG4585	Histidine kinase
HZT45_RS09985	COG0730	response to heat
HZT45_RS10000	COG5444	nuclease activity
HZT45_RS10010	COG4282	regulation of fungal-type cell wall biogenesis
HZT45_RS10015	COG1525	nuclease
HZT45_RS10020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZT45_RS10040	COG1846	Transcriptional regulator
HZT45_RS10045	COG4698	Protein conserved in bacteria
HZT45_RS10050	COG2755	lipolytic protein G-D-S-L family
HZT45_RS10055	COG1999	signal sequence binding
HZT45_RS10065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZT45_RS10075	COG1272	protein, Hemolysin III
HZT45_RS10085	COG0204	Acyl-transferase
HZT45_RS10090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZT45_RS10105	COG2136	Putative SAM-dependent methyltransferase
HZT45_RS10105	COG2521	methyltransferase
HZT45_RS10120	COG1413	lyase activity
HZT45_RS10125	COG1418	mRNA catabolic process
HZT45_RS10130	COG0386	Belongs to the glutathione peroxidase family
HZT45_RS10140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZT45_RS10150	COG1278	Cold shock
HZT45_RS10170	COG0328	RNA-DNA hybrid ribonuclease activity
HZT45_RS10175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZT45_RS10180	COG0328	RNA-DNA hybrid ribonuclease activity
HZT45_RS10190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZT45_RS10205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZT45_RS10215	COG1755	Isoprenylcysteine carboxyl methyltransferase
HZT45_RS10220	COG3424	synthase
HZT45_RS10240	COG2323	membrane
HZT45_RS10245	COG1335	isochorismatase
HZT45_RS10255	COG2233	PERMEase
HZT45_RS10265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZT45_RS10270	COG1199	ATP-dependent helicase activity
HZT45_RS10285	COG0116	Belongs to the methyltransferase superfamily
HZT45_RS10315	COG3359	exonuclease
HZT45_RS10320	COG1205	dead DEAH box helicase
HZT45_RS10320	COG1111	helicase
HZT45_RS10325	COG2190	(PTS) system
HZT45_RS10330	COG0071	Belongs to the small heat shock protein (HSP20) family
HZT45_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT45_RS10370	COG4499	WXG100 protein secretion system (Wss), protein YukC
HZT45_RS10380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZT45_RS10385	COG3935	DnaD domain protein
HZT45_RS10395	COG0436	Aminotransferase
HZT45_RS10400	COG5353	protein conserved in bacteria
HZT45_RS10410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZT45_RS10410	COG1199	ATP-dependent helicase activity
HZT45_RS10440	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS10445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZT45_RS10460	COG1694	Mazg nucleotide pyrophosphohydrolase
HZT45_RS10465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS10470	COG2140	Oxalate decarboxylase
HZT45_RS10480	COG4347	Protein of unknown function (DUF1405)
HZT45_RS10485	COG2010	Cytochrome c
HZT45_RS10485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZT45_RS10490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZT45_RS10495	COG0723	plastoquinol--plastocyanin reductase activity
HZT45_RS10510	COG0457	Tetratricopeptide repeat
HZT45_RS10520	COG0287	Prephenate dehydrogenase
HZT45_RS10555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZT45_RS10560	COG4401	Chorismate mutase type I
HZT45_RS10575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZT45_RS10580	COG0105	UTP biosynthetic process
HZT45_RS10585	COG0142	geranyltranstransferase activity
HZT45_RS10595	COG0142	geranyltranstransferase activity
HZT45_RS10610	COG0776	regulation of translation
HZT45_RS10615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZT45_RS10655	COG0539	negative regulation of cytoplasmic translation
HZT45_RS10670	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HZT45_RS10675	COG2959	enzyme of heme biosynthesis
HZT45_RS10680	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS10680	COG3773	Cell wall hydrolase
HZT45_RS10685	COG2339	peptidase activity
HZT45_RS10690	COG0492	ferredoxin-NADP+ reductase activity
HZT45_RS10695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZT45_RS10700	COG4862	establishment of competence for transformation
HZT45_RS10705	COG1408	metallophosphoesterase
HZT45_RS10715	COG1388	LysM domain
HZT45_RS10720	COG1266	CAAX protease self-immunity
HZT45_RS10725	COG0514	ATP-dependent DNA helicase (RecQ)
HZT45_RS10730	COG4955	Helix-turn-helix domain
HZT45_RS10735	COG1141	Ferredoxin
HZT45_RS10740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HZT45_RS10745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZT45_RS10755	COG1595	DNA-templated transcription, initiation
HZT45_RS10760	COG5002	protein histidine kinase activity
HZT45_RS10765	COG0745	RESPONSE REGULATOR receiver
HZT45_RS10770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZT45_RS10775	COG1333	cytochrome c biogenesis protein
HZT45_RS10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS10785	COG1187	pseudouridine synthase activity
HZT45_RS10790	COG0700	Nucleoside recognition
HZT45_RS10795	COG2715	membrane protein required for spore maturation
HZT45_RS10800	COG1686	Belongs to the peptidase S11 family
HZT45_RS10825	COG1547	Domain of unknown function (DUF309)
HZT45_RS10830	COG0456	acetyltransferase
HZT45_RS10845	COG0307	riboflavin synthase, alpha
HZT45_RS10850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZT45_RS10850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZT45_RS10860	COG0681	Belongs to the peptidase S26 family
HZT45_RS10870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZT45_RS10875	COG4086	secreted protein
HZT45_RS10880	COG0019	diaminopimelate decarboxylase activity
HZT45_RS10885	COG0697	spore germination
HZT45_RS10900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZT45_RS10920	COG1191	sigma factor activity
HZT45_RS10930	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS10935	COG1686	Belongs to the peptidase S11 family
HZT45_RS10940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZT45_RS10945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZT45_RS10950	COG4974	Belongs to the 'phage' integrase family
HZT45_RS10960	COG0735	belongs to the Fur family
HZT45_RS10965	COG1300	Membrane
HZT45_RS10980	COG0281	malic enzyme
HZT45_RS10985	COG1757	Na H antiporter
HZT45_RS10990	COG1027	Aspartate ammonia-lyase
HZT45_RS10995	COG0252	asparaginase activity
HZT45_RS11000	COG1396	sequence-specific DNA binding
HZT45_RS11005	COG1379	DNA repair
HZT45_RS11010	COG0494	nUDIX hydrolase
HZT45_RS11020	COG0667	Aldo Keto reductase
HZT45_RS11030	COG1073	alpha beta
HZT45_RS11040	COG4918	Iron-sulphur cluster biosynthesis
HZT45_RS11045	COG0456	acetyltransferase
HZT45_RS11045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HZT45_RS11050	COG2329	Antibiotic biosynthesis monooxygenase
HZT45_RS11055	COG0456	acetyltransferase
HZT45_RS11060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZT45_RS11075	COG0628	permease
HZT45_RS11085	COG0346	lactoylglutathione lyase activity
HZT45_RS11100	COG0300	oxidoreductase activity
HZT45_RS11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS11110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZT45_RS11115	COG1024	Enoyl-CoA hydratase
HZT45_RS11120	COG3425	synthase
HZT45_RS11125	COG2124	cytochrome p450
HZT45_RS11130	COG3321	synthase
HZT45_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS11130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS11135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11135	COG3321	synthase
HZT45_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS11135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS11140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11140	COG0300	oxidoreductase activity
HZT45_RS11140	COG3321	synthase
HZT45_RS11145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11145	COG3321	synthase
HZT45_RS11145	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS11145	COG0300	oxidoreductase activity
HZT45_RS11150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS11150	COG3321	synthase
HZT45_RS11150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11155	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS11155	COG3321	synthase
HZT45_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11155	COG0300	oxidoreductase activity
HZT45_RS11160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11160	COG3321	synthase
HZT45_RS11160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS11160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZT45_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS11185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZT45_RS11185	COG2070	2-Nitropropane dioxygenase
HZT45_RS11190	COG0250	Participates in transcription elongation, termination and antitermination
HZT45_RS11210	COG0596	Alpha beta hydrolase
HZT45_RS11225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZT45_RS11230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZT45_RS11245	COG0706	membrane insertase activity
HZT45_RS11250	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZT45_RS11255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZT45_RS11260	COG0346	lactoylglutathione lyase activity
HZT45_RS11270	COG1376	ErfK ybiS ycfS ynhG family protein
HZT45_RS11275	COG4129	membrane
HZT45_RS11280	COG1126	abc transporter atp-binding protein
HZT45_RS11285	COG0765	amino acid transport
HZT45_RS11290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS11300	COG1597	lipid kinase activity
HZT45_RS11305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZT45_RS11310	COG0022	dehydrogenase e1 component
HZT45_RS11315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZT45_RS11320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZT45_RS11325	COG3426	butyrate kinase activity
HZT45_RS11330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZT45_RS11335	COG0280	phosphate acetyltransferase
HZT45_RS11340	COG3829	transcription factor binding
HZT45_RS11340	COG3290	protein histidine kinase activity
HZT45_RS11350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HZT45_RS11355	COG2079	MmgE PrpD family protein
HZT45_RS11360	COG0372	Belongs to the citrate synthase family
HZT45_RS11365	COG1960	acyl-CoA dehydrogenase activity
HZT45_RS11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZT45_RS11375	COG0183	Belongs to the thiolase family
HZT45_RS11380	COG0584	glycerophosphoryl diester phosphodiesterase
HZT45_RS11385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS11410	COG1902	pentaerythritol trinitrate reductase activity
HZT45_RS11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZT45_RS11430	COG0745	RESPONSE REGULATOR receiver
HZT45_RS11435	COG0750	zinc metalloprotease
HZT45_RS11440	COG0497	DNA recombination
HZT45_RS11450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZT45_RS11460	COG0142	geranyltranstransferase activity
HZT45_RS11470	COG1570	exodeoxyribonuclease VII activity
HZT45_RS11485	COG1302	Protein conserved in bacteria
HZT45_RS11490	COG0439	Biotin carboxylase
HZT45_RS11495	COG0511	ligase activity, forming carbon-carbon bonds
HZT45_RS11535	COG3854	ATPases associated with a variety of cellular activities
HZT45_RS11550	COG0006	proline dipeptidase activity
HZT45_RS11560	COG3872	metal-dependent enzyme
HZT45_RS11570	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZT45_RS11585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS11605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZT45_RS11620	COG1396	sequence-specific DNA binding
HZT45_RS11630	COG0681	Belongs to the peptidase S26 family
HZT45_RS11655	COG4940	Competence protein ComGF
HZT45_RS11665	COG4970	Tfp pilus assembly protein FimT
HZT45_RS11670	COG4537	Required for transformation and DNA binding
HZT45_RS11675	COG1459	type II secretion system
HZT45_RS11680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZT45_RS11685	COG0598	Magnesium transport protein CorA
HZT45_RS11690	COG1253	flavin adenine dinucleotide binding
HZT45_RS11695	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS11705	COG1393	Belongs to the ArsC family
HZT45_RS11715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS11725	COG0011	TIGRFAM Protein of
HZT45_RS11735	COG2866	Carboxypeptidase
HZT45_RS11740	COG1940	carbohydrate kinase activity
HZT45_RS11745	COG4483	Protein conserved in bacteria
HZT45_RS11750	COG1757	Na H antiporter
HZT45_RS11760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZT45_RS11775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZT45_RS11780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZT45_RS11785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZT45_RS11790	COG0581	inorganic phosphate transmembrane transporter activity
HZT45_RS11795	COG0573	inorganic phosphate transmembrane transporter activity
HZT45_RS11800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZT45_RS11810	COG0477	Major facilitator Superfamily
HZT45_RS11815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZT45_RS11820	COG2839	Protein conserved in bacteria
HZT45_RS11825	COG5521	maltodextrose utilization protein MalA
HZT45_RS11830	COG1388	LysM domain
HZT45_RS11840	COG4709	membrane
HZT45_RS11845	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HZT45_RS11850	COG0735	belongs to the Fur family
HZT45_RS11855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS11870	COG0513	Belongs to the DEAD box helicase family
HZT45_RS11890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZT45_RS11895	COG2384	SAM-dependent methyltransferase
HZT45_RS11900	COG2010	Cytochrome c
HZT45_RS11905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZT45_RS11910	COG0358	DNA primase activity
HZT45_RS11925	COG0517	IMP dehydrogenase activity
HZT45_RS11930	COG0751	glycine-tRNA ligase activity
HZT45_RS11950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZT45_RS11955	COG0295	cytidine deaminase activity
HZT45_RS11960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZT45_RS11970	COG1480	7TM receptor with intracellular HD hydrolase
HZT45_RS11975	COG1702	phosphate starvation-inducible protein PhoH
HZT45_RS11980	COG0561	phosphatase activity
HZT45_RS11995	COG4864	UPF0365 protein
HZT45_RS12000	COG1030	water channel activity
HZT45_RS12005	COG1610	YqeY-like protein
HZT45_RS12015	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZT45_RS12020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZT45_RS12025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZT45_RS12055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZT45_RS12070	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS12085	COG1466	dna polymerase III delta subunit
HZT45_RS12100	COG2333	competence protein COMEC
HZT45_RS12100	COG0658	competence protein
HZT45_RS12105	COG2131	deaminase
HZT45_RS12110	COG1596	polysaccharide export
HZT45_RS12110	COG1555	photosystem II stabilization
HZT45_RS12115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZT45_RS12120	COG2226	methyltransferase
HZT45_RS12125	COG0799	negative regulation of ribosome biogenesis
HZT45_RS12130	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZT45_RS12140	COG1534	Rna-binding protein
HZT45_RS12145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZT45_RS12150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZT45_RS12155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HZT45_RS12165	COG2755	lipolytic protein G-D-S-L family
HZT45_RS12175	COG0398	Pfam SNARE associated Golgi protein
HZT45_RS12205	COG2207	Transcriptional regulator
HZT45_RS12205	COG3708	Transcriptional regulator
HZT45_RS12215	COG0563	adenylate kinase activity
HZT45_RS12230	COG2318	DinB family
HZT45_RS12240	COG0561	phosphatase activity
HZT45_RS12245	COG0561	phosphatase activity
HZT45_RS12255	COG1482	cell wall glycoprotein biosynthetic process
HZT45_RS12260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS12260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZT45_RS12260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZT45_RS12265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS12265	COG3711	transcriptional antiterminator
HZT45_RS12275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZT45_RS12280	COG0583	DNA-binding transcription factor activity
HZT45_RS12285	COG2814	Major facilitator Superfamily
HZT45_RS12290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZT45_RS12290	COG2124	cytochrome p450
HZT45_RS12295	COG1309	transcriptional regulator
HZT45_RS12300	COG2226	methyltransferase
HZT45_RS12315	COG2116	formate transmembrane transporter activity
HZT45_RS12320	COG5609	conserved protein (DUF2294)
HZT45_RS12325	COG3383	formate dehydrogenase (NAD+) activity
HZT45_RS12330	COG2427	Protein of unknown function (DUF1641)
HZT45_RS12340	COG0626	cystathionine gamma-synthase activity
HZT45_RS12345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZT45_RS12370	COG0768	penicillin binding
HZT45_RS12395	COG4122	O-methyltransferase activity
HZT45_RS12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZT45_RS12425	COG0628	permease
HZT45_RS12430	COG1126	abc transporter atp-binding protein
HZT45_RS12435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS12440	COG0765	amino acid transport
HZT45_RS12445	COG0765	amino acid transport
HZT45_RS12460	COG3881	PFAM PRC-barrel domain
HZT45_RS12465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZT45_RS12470	COG0457	Tetratricopeptide repeat
HZT45_RS12480	COG1104	cysteine desulfurase activity
HZT45_RS12485	COG1959	2 iron, 2 sulfur cluster binding
HZT45_RS12490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZT45_RS12495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZT45_RS12520	COG3103	Sh3 type 3 domain protein
HZT45_RS12520	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS12520	COG4991	sh3 domain protein
HZT45_RS12530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZT45_RS12540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZT45_RS12540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZT45_RS12545	COG5416	Lipopolysaccharide assembly protein A domain
HZT45_RS12550	COG0490	domain, Protein
HZT45_RS12555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZT45_RS12555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZT45_RS12565	COG2244	polysaccharide biosynthetic process
HZT45_RS12570	COG2323	membrane
HZT45_RS12580	COG1862	Preprotein translocase
HZT45_RS12625	COG1388	LysM domain
HZT45_RS12635	COG0157	Belongs to the NadC ModD family
HZT45_RS12640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZT45_RS12645	COG1104	cysteine desulfurase activity
HZT45_RS12650	COG1827	regulation of RNA biosynthetic process
HZT45_RS12655	COG0077	Prephenate dehydratase
HZT45_RS12670	COG3290	protein histidine kinase activity
HZT45_RS12675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZT45_RS12680	COG2868	ribosomal protein
HZT45_RS12690	COG1994	Peptidase M50
HZT45_RS12695	COG0739	heme binding
HZT45_RS12700	COG2894	cell division
HZT45_RS12710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HZT45_RS12720	COG1077	Cell shape determining protein MreB Mrl
HZT45_RS12740	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZT45_RS12745	COG0285	dihydrofolate synthase activity
HZT45_RS12750	COG0525	valine-tRNA ligase activity
HZT45_RS12760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZT45_RS12765	COG1388	LysM domain
HZT45_RS12775	COG0113	porphobilinogen synthase activity
HZT45_RS12780	COG1587	Uroporphyrinogen-III synthase
HZT45_RS12790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZT45_RS12810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZT45_RS12815	COG0470	DNA polymerase III
HZT45_RS12815	COG1067	ATP-dependent peptidase activity
HZT45_RS12830	COG1477	protein flavinylation
HZT45_RS12830	COG0457	Tetratricopeptide repeat
HZT45_RS12845	COG0473	3-isopropylmalate dehydrogenase activity
HZT45_RS12860	COG0440	acetolactate synthase activity
HZT45_RS12865	COG0028	Belongs to the TPP enzyme family
HZT45_RS12890	COG0622	Phosphoesterase
HZT45_RS12895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZT45_RS12905	COG5401	PFAM Sporulation and spore germination
HZT45_RS12915	COG1846	Transcriptional regulator
HZT45_RS12920	COG2197	response regulator
HZT45_RS12925	COG0824	Thioesterase
HZT45_RS12930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZT45_RS12935	COG1053	succinate dehydrogenase
HZT45_RS12940	COG2009	succinate dehydrogenase
HZT45_RS12945	COG1719	4-vinyl reductase, 4VR
HZT45_RS12950	COG0527	aspartate kinase activity
HZT45_RS12960	COG3118	belongs to the thioredoxin family
HZT45_RS12965	COG3534	alpha-L-arabinofuranosidase
HZT45_RS12970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZT45_RS12975	COG2086	electron transfer activity
HZT45_RS12980	COG1024	Enoyl-CoA hydratase
HZT45_RS12985	COG1309	transcriptional regulator
HZT45_RS12990	COG0318	PFAM AMP-dependent synthetase and ligase
HZT45_RS13000	COG3766	membrane
HZT45_RS13010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZT45_RS13010	COG1796	DNA polymerase
HZT45_RS13015	COG1286	toxin biosynthetic process
HZT45_RS13030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT45_RS13030	COG0072	phenylalanine-tRNA ligase activity
HZT45_RS13035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZT45_RS13040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZT45_RS13050	COG3835	regulator
HZT45_RS13055	COG0277	FAD linked oxidase domain protein
HZT45_RS13060	COG0247	lactate metabolic process
HZT45_RS13065	COG1966	Carbon starvation protein
HZT45_RS13070	COG3534	alpha-L-arabinofuranosidase
HZT45_RS13075	COG0395	ABC-type sugar transport system, permease component
HZT45_RS13080	COG1175	transmembrane transport
HZT45_RS13085	COG1653	transport
HZT45_RS13095	COG0647	UMP catabolic process
HZT45_RS13100	COG0235	Class ii aldolase
HZT45_RS13105	COG1069	ribulokinase activity
HZT45_RS13110	COG2160	L-arabinose isomerase activity
HZT45_RS13115	COG3507	Belongs to the glycosyl hydrolase 43 family
HZT45_RS13120	COG1363	Peptidase, m42
HZT45_RS13130	COG3326	Membrane
HZT45_RS13145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZT45_RS13150	COG1346	cytolysis
HZT45_RS13155	COG1380	Effector of murein hydrolase LrgA
HZT45_RS13160	COG3279	Response regulator of the LytR AlgR family
HZT45_RS13165	COG3275	phosphorelay sensor kinase activity
HZT45_RS13170	COG1011	Hydrolase
HZT45_RS13185	COG0398	Pfam SNARE associated Golgi protein
HZT45_RS13190	COG1484	DNA-dependent DNA replication
HZT45_RS13195	COG3611	Membrane attachment protein
HZT45_RS13210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZT45_RS13215	COG1733	regulation of RNA biosynthetic process
HZT45_RS13220	COG2814	Major facilitator Superfamily
HZT45_RS13225	COG0656	L-ascorbic acid biosynthetic process
HZT45_RS13230	COG0237	dephospho-CoA kinase activity
HZT45_RS13235	COG1971	Probably functions as a manganese efflux pump
HZT45_RS13240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZT45_RS13245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZT45_RS13245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZT45_RS13250	COG5002	protein histidine kinase activity
HZT45_RS13255	COG0745	RESPONSE REGULATOR receiver
HZT45_RS13265	COG0538	isocitrate dehydrogenase activity
HZT45_RS13270	COG0372	Belongs to the citrate synthase family
HZT45_RS13295	COG0628	permease
HZT45_RS13300	COG3030	protein affecting phage T7 exclusion by the F plasmid
HZT45_RS13305	COG0469	pyruvate kinase activity
HZT45_RS13325	COG0281	malic enzyme
HZT45_RS13330	COG0587	DNA-directed DNA polymerase activity
HZT45_RS13350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZT45_RS13360	COG4109	DRTGG domain
HZT45_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS13385	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZT45_RS13395	COG0827	DNA restriction-modification system
HZT45_RS13400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZT45_RS13405	COG3874	Sporulation protein YtfJ
HZT45_RS13415	COG1714	RDD family
HZT45_RS13420	COG0616	signal peptide processing
HZT45_RS13425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZT45_RS13430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZT45_RS13435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZT45_RS13450	COG1104	cysteine desulfurase activity
HZT45_RS13455	COG1114	Component of the transport system for branched-chain amino acids
HZT45_RS13465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZT45_RS13470	COG1309	transcriptional regulator
HZT45_RS13475	COG1956	GAF domain-containing protein
HZT45_RS13480	COG2199	diguanylate cyclase activity
HZT45_RS13480	COG2203	Gaf domain
HZT45_RS13490	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS13495	COG4282	regulation of fungal-type cell wall biogenesis
HZT45_RS13500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZT45_RS13500	COG1017	nitric oxide dioxygenase activity
HZT45_RS13510	COG0693	protein deglycase activity
HZT45_RS13525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZT45_RS13530	COG1378	Sugar-specific transcriptional regulator TrmB
HZT45_RS13550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZT45_RS13555	COG0454	-acetyltransferase
HZT45_RS13560	COG0517	IMP dehydrogenase activity
HZT45_RS13565	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZT45_RS13570	COG1360	Flagellar Motor Protein
HZT45_RS13575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZT45_RS13580	COG1609	Transcriptional regulator
HZT45_RS13585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZT45_RS13585	COG1605	Chorismate mutase
HZT45_RS13590	COG3118	belongs to the thioredoxin family
HZT45_RS13595	COG4980	gas vesicle protein
HZT45_RS13600	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HZT45_RS13610	COG1674	ftsk spoiiie
HZT45_RS13615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZT45_RS13625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS13635	COG1363	Peptidase, m42
HZT45_RS13640	COG5584	Small secreted protein
HZT45_RS13645	COG0281	malic enzyme
HZT45_RS13650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZT45_RS13665	COG0510	thiamine kinase activity
HZT45_RS13670	COG1597	lipid kinase activity
HZT45_RS13680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HZT45_RS13685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZT45_RS13690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZT45_RS13695	COG2252	PERMEase
HZT45_RS13700	COG4473	ABC transporter
HZT45_RS13705	COG1131	(ABC) transporter
HZT45_RS13710	COG1349	DNA-binding transcription factor activity
HZT45_RS13715	COG1187	pseudouridine synthase activity
HZT45_RS13720	COG2244	polysaccharide biosynthetic process
HZT45_RS13725	COG2081	HI0933 family
HZT45_RS13730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZT45_RS13740	COG1609	Transcriptional regulator
HZT45_RS13745	COG1653	transport
HZT45_RS13750	COG1175	transmembrane transport
HZT45_RS13755	COG0395	ABC-type sugar transport system, permease component
HZT45_RS13760	COG1486	melibiose metabolic process
HZT45_RS13770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZT45_RS13785	COG1366	Belongs to the anti-sigma-factor antagonist family
HZT45_RS13785	COG2202	Pas domain
HZT45_RS13790	COG2814	Major facilitator Superfamily
HZT45_RS13795	COG5522	Integral membrane protein (intg_mem_TP0381)
HZT45_RS13800	COG0577	efflux transmembrane transporter activity
HZT45_RS13805	COG1136	(ABC) transporter
HZT45_RS13810	COG2205	protein histidine kinase activity
HZT45_RS13815	COG0745	RESPONSE REGULATOR receiver
HZT45_RS13820	COG0577	efflux transmembrane transporter activity
HZT45_RS13825	COG1136	(ABC) transporter
HZT45_RS13845	COG1131	(ABC) transporter
HZT45_RS13850	COG1725	Transcriptional regulator
HZT45_RS13860	COG1242	4 iron, 4 sulfur cluster binding
HZT45_RS13865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZT45_RS13875	COG0584	glycerophosphoryl diester phosphodiesterase
HZT45_RS13885	COG2267	carboxylic ester hydrolase activity
HZT45_RS13890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZT45_RS13895	COG1113	amino acid transport
HZT45_RS13900	COG0367	asparagine synthase
HZT45_RS13920	COG1506	peptidase
HZT45_RS13925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZT45_RS13930	COG1116	anion transmembrane transporter activity
HZT45_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZT45_RS13940	COG0494	nUDIX hydrolase
HZT45_RS13945	COG4824	toxin secretion phage lysis holin
HZT45_RS13950	COG0783	Belongs to the Dps family
HZT45_RS13975	COG0288	reversible hydration of carbon dioxide
HZT45_RS13985	COG1271	oxidase subunit
HZT45_RS13990	COG1294	oxidase, subunit
HZT45_RS14005	COG4948	Mandelate Racemase Muconate Lactonizing
HZT45_RS14015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZT45_RS14020	COG0596	Alpha beta hydrolase
HZT45_RS14030	COG1169	isochorismate synthase
HZT45_RS14035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZT45_RS14040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZT45_RS14145	COG3859	Proton-coupled thiamine transporter YuaJ
HZT45_RS14150	COG2268	Band 7 protein
HZT45_RS14155	COG1585	Membrane protein implicated in regulation of membrane protease activity
HZT45_RS14160	COG2318	DinB family
HZT45_RS14170	COG1454	alcohol dehydrogenase
HZT45_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS14180	COG1510	regulation of RNA biosynthetic process
HZT45_RS14190	COG0569	domain protein
HZT45_RS14195	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZT45_RS14200	COG1017	nitric oxide dioxygenase activity
HZT45_RS14200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZT45_RS14215	COG0457	Tetratricopeptide repeat
HZT45_RS14250	COG0628	permease
HZT45_RS14255	COG0673	inositol 2-dehydrogenase activity
HZT45_RS14260	COG0693	protein deglycase activity
HZT45_RS14265	COG0840	transmembrane signaling receptor activity
HZT45_RS14270	COG0840	transmembrane signaling receptor activity
HZT45_RS14275	COG0840	transmembrane signaling receptor activity
HZT45_RS14280	COG0840	transmembrane signaling receptor activity
HZT45_RS14295	COG2070	2-Nitropropane dioxygenase
HZT45_RS14300	COG0432	Pfam Uncharacterised protein family UPF0047
HZT45_RS14305	COG0366	Alpha amylase catalytic
HZT45_RS14310	COG1253	flavin adenine dinucleotide binding
HZT45_RS14315	COG2738	Putative neutral zinc metallopeptidase
HZT45_RS14330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZT45_RS14355	COG1335	isochorismatase
HZT45_RS14360	COG1979	alcohol dehydrogenase
HZT45_RS14365	COG1979	alcohol dehydrogenase
HZT45_RS14370	COG2155	Conserved Protein
HZT45_RS14375	COG1098	S1 RNA binding domain
HZT45_RS14380	COG0436	Aminotransferase
HZT45_RS14385	COG1522	sequence-specific DNA binding
HZT45_RS14390	COG2267	carboxylic ester hydrolase activity
HZT45_RS14400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZT45_RS14405	COG2205	protein histidine kinase activity
HZT45_RS14415	COG5018	Exonuclease
HZT45_RS14420	COG2814	Major facilitator Superfamily
HZT45_RS14425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT45_RS14430	COG3011	Protein conserved in bacteria
HZT45_RS14440	COG3290	protein histidine kinase activity
HZT45_RS14445	COG4565	transcriptional regulatory protein
HZT45_RS14475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZT45_RS14475	COG2111	Na H antiporter
HZT45_RS14480	COG2111	Na H antiporter
HZT45_RS14485	COG1006	Multisubunit Na H antiporter MnhC subunit
HZT45_RS14490	COG0651	ATP synthesis coupled electron transport
HZT45_RS14495	COG1863	multisubunit Na H antiporter MnhE subunit
HZT45_RS14500	COG2212	antiporter activity
HZT45_RS14505	COG1320	monovalent cation:proton antiporter activity
HZT45_RS14510	COG2050	protein possibly involved in aromatic compounds catabolism
HZT45_RS14515	COG2197	response regulator
HZT45_RS14520	COG4585	Histidine kinase
HZT45_RS14530	COG0142	geranyltranstransferase activity
HZT45_RS14545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HZT45_RS14550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZT45_RS14555	COG1335	isochorismatase
HZT45_RS14560	COG5506	Protein of unknown function (DUF1694)
HZT45_RS14575	COG0628	permease
HZT45_RS14585	COG1418	mRNA catabolic process
HZT45_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS14600	COG1511	domain protein
HZT45_RS14605	COG0433	COG0433 Predicted ATPase
HZT45_RS14605	COG1674	ftsk spoiiie
HZT45_RS14610	COG4499	WXG100 protein secretion system (Wss), protein YukC
HZT45_RS14615	COG5417	Belongs to the EsaB family
HZT45_RS14620	COG4842	Belongs to the WXG100 family
HZT45_RS14625	COG2508	Transcriptional regulator
HZT45_RS14625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HZT45_RS14630	COG0686	Belongs to the AlaDH PNT family
HZT45_RS14635	COG5634	Uncharacterized conserved protein (DUF2278)
HZT45_RS14640	COG3251	PFAM MbtH domain protein
HZT45_RS14645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZT45_RS14650	COG3433	isochorismatase activity
HZT45_RS14650	COG1535	isochorismatase
HZT45_RS14655	COG1021	2,3-dihydroxybenzoate-AMP ligase
HZT45_RS14660	COG1169	isochorismate synthase
HZT45_RS14665	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS14670	COG2819	hydrolase of the alpha beta superfamily
HZT45_RS14675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZT45_RS14680	COG1268	BioY protein
HZT45_RS14685	COG2056	Na+-H+ antiporter family
HZT45_RS14695	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HZT45_RS14700	COG3584	3D domain protein
HZT45_RS14715	COG1252	NADH dehydrogenase
HZT45_RS14745	COG1131	(ABC) transporter
HZT45_RS14765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZT45_RS14770	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HZT45_RS14775	COG0316	Belongs to the HesB IscA family
HZT45_RS14785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZT45_RS14795	COG1252	NADH dehydrogenase
HZT45_RS14800	COG4837	Protein of unknown function (DUF1462)
HZT45_RS14805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZT45_RS14810	COG1506	peptidase
HZT45_RS14810	COG0823	Involved in the tonB-independent uptake of proteins
HZT45_RS14810	COG4946	Tricorn protease homolog
HZT45_RS14820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZT45_RS14825	COG0460	homoserine dehydrogenase
HZT45_RS14830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZT45_RS14835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZT45_RS14840	COG0647	UMP catabolic process
HZT45_RS14845	COG2445	Protein of unknown function DUF86
HZT45_RS14850	COG4470	Protein conserved in bacteria
HZT45_RS14860	COG0739	heme binding
HZT45_RS14870	COG0737	Belongs to the 5'-nucleotidase family
HZT45_RS14875	COG0730	response to heat
HZT45_RS14880	COG1801	Protein of unknown function DUF72
HZT45_RS14895	COG2508	Transcriptional regulator
HZT45_RS14900	COG0457	Tetratricopeptide repeat
HZT45_RS14910	COG2814	Major facilitator Superfamily
HZT45_RS14915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZT45_RS14920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZT45_RS14925	COG2356	endonuclease I
HZT45_RS14930	COG3842	ATPase activity
HZT45_RS14935	COG2188	Transcriptional regulator
HZT45_RS14940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZT45_RS14945	COG0395	ABC-type sugar transport system, permease component
HZT45_RS14950	COG1175	transmembrane transport
HZT45_RS14955	COG1653	transport
HZT45_RS14960	COG2222	sugar isomerase
HZT45_RS14965	COG0789	Transcriptional regulator
HZT45_RS14980	COG0322	excinuclease ABC activity
HZT45_RS14985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZT45_RS14990	COG2226	methyltransferase
HZT45_RS15000	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS15005	COG0719	Fe-S assembly protein
HZT45_RS15010	COG0822	iron-sulfur transferase activity
HZT45_RS15015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZT45_RS15020	COG0719	Fe-S assembly protein
HZT45_RS15025	COG0396	ATPase activity
HZT45_RS15035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZT45_RS15040	COG1464	Belongs to the NlpA lipoprotein family
HZT45_RS15045	COG2011	ABC-type metal ion transport system permease component
HZT45_RS15050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZT45_RS15060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZT45_RS15065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZT45_RS15080	COG1393	Belongs to the ArsC family
HZT45_RS15085	COG1960	acyl-CoA dehydrogenase activity
HZT45_RS15090	COG0183	Belongs to the thiolase family
HZT45_RS15095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZT45_RS15095	COG1024	Enoyl-CoA hydratase
HZT45_RS15115	COG5577	PFAM Coat F domain
HZT45_RS15120	COG1846	Transcriptional regulator
HZT45_RS15125	COG0477	Major facilitator Superfamily
HZT45_RS15130	COG1942	4-Oxalocrotonate Tautomerase
HZT45_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS15140	COG0583	DNA-binding transcription factor activity
HZT45_RS15150	COG0583	DNA-binding transcription factor activity
HZT45_RS15170	COG1120	ATPase activity
HZT45_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS15190	COG0783	Belongs to the Dps family
HZT45_RS15195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT45_RS15200	COG0745	RESPONSE REGULATOR receiver
HZT45_RS15205	COG2205	protein histidine kinase activity
HZT45_RS15205	COG2770	Histidine kinase
HZT45_RS15215	COG1309	transcriptional regulator
HZT45_RS15220	COG0114	fumarate hydratase activity
HZT45_RS15230	COG0697	spore germination
HZT45_RS15235	COG0814	amino acid
HZT45_RS15245	COG2197	response regulator
HZT45_RS15250	COG4585	Histidine kinase
HZT45_RS15255	COG4758	membrane
HZT45_RS15260	COG3595	metallopeptidase activity
HZT45_RS15265	COG1842	Phage shock protein A
HZT45_RS15270	COG4758	membrane
HZT45_RS15275	COG2814	Major facilitator Superfamily
HZT45_RS15280	COG2096	Adenosyltransferase
HZT45_RS15285	COG1120	ATPase activity
HZT45_RS15290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS15295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZT45_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS15305	COG3386	PFAM SMP-30 Gluconolaconase
HZT45_RS15310	COG2205	protein histidine kinase activity
HZT45_RS15315	COG0745	RESPONSE REGULATOR receiver
HZT45_RS15325	COG1191	sigma factor activity
HZT45_RS15335	COG2140	Oxalate decarboxylase
HZT45_RS15345	COG1120	ATPase activity
HZT45_RS15350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS15355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS15360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZT45_RS15365	COG0531	amino acid
HZT45_RS15375	COG1988	membrane-bound metal-dependent
HZT45_RS15380	COG1368	sulfuric ester hydrolase activity
HZT45_RS15385	COG1910	domain protein
HZT45_RS15390	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZT45_RS15395	COG4149	molybdate abc transporter
HZT45_RS15400	COG2197	response regulator
HZT45_RS15405	COG3850	Histidine kinase
HZT45_RS15410	COG1131	(ABC) transporter
HZT45_RS15420	COG0842	Transport permease protein
HZT45_RS15425	COG0656	L-ascorbic acid biosynthetic process
HZT45_RS15445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZT45_RS15450	COG3973	AAA domain
HZT45_RS15455	COG2860	membrane
HZT45_RS15465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZT45_RS15470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZT45_RS15475	COG2217	Heavy metal translocating P-type atpase
HZT45_RS15480	COG2217	Heavy metal translocating P-type atpase
HZT45_RS15485	COG2608	mercury ion transmembrane transporter activity
HZT45_RS15490	COG1937	Protein conserved in bacteria
HZT45_RS15495	COG0673	inositol 2-dehydrogenase activity
HZT45_RS15510	COG2814	Major facilitator Superfamily
HZT45_RS15525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS15530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZT45_RS15535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS15540	COG1126	abc transporter atp-binding protein
HZT45_RS15545	COG0765	amino acid transport
HZT45_RS15550	COG0765	amino acid transport
HZT45_RS15555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZT45_RS15565	COG0454	-acetyltransferase
HZT45_RS15570	COG0583	DNA-binding transcription factor activity
HZT45_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS15580	COG2732	(Barnase) inhibitor
HZT45_RS15595	COG0557	exoribonuclease II activity
HZT45_RS15600	COG1647	Serine aminopeptidase, S33
HZT45_RS15605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZT45_RS15610	COG1476	TRANSCRIPTIONal
HZT45_RS15615	COG1396	sequence-specific DNA binding
HZT45_RS15620	COG1396	sequence-specific DNA binding
HZT45_RS15625	COG1733	regulation of RNA biosynthetic process
HZT45_RS15650	COG1131	(ABC) transporter
HZT45_RS15655	COG1174	glycine betaine transport
HZT45_RS15660	COG1732	Glycine betaine
HZT45_RS15665	COG1174	glycine betaine transport
HZT45_RS15670	COG0517	IMP dehydrogenase activity
HZT45_RS15670	COG1125	glycine betaine transport
HZT45_RS15675	COG1510	regulation of RNA biosynthetic process
HZT45_RS15680	COG1174	glycine betaine transport
HZT45_RS15685	COG1732	Glycine betaine
HZT45_RS15690	COG1174	glycine betaine transport
HZT45_RS15695	COG1125	glycine betaine transport
HZT45_RS15695	COG0517	IMP dehydrogenase activity
HZT45_RS15700	COG1510	regulation of RNA biosynthetic process
HZT45_RS15705	COG2095	MarC family integral membrane protein
HZT45_RS15710	COG3064	Membrane
HZT45_RS15715	COG4640	response to antibiotic
HZT45_RS15720	COG0456	acetyltransferase
HZT45_RS15735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZT45_RS15750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZT45_RS15755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZT45_RS15760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZT45_RS15770	COG2234	aminopeptidase activity
HZT45_RS15790	COG0126	phosphoglycerate kinase activity
HZT45_RS15795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZT45_RS15800	COG2390	Transcriptional regulator
HZT45_RS15805	COG2814	Major facilitator Superfamily
HZT45_RS15810	COG1609	Transcriptional regulator
HZT45_RS15815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS15825	COG0583	DNA-binding transcription factor activity
HZT45_RS15830	COG0697	spore germination
HZT45_RS15835	COG1113	amino acid transport
HZT45_RS15845	COG1609	Transcriptional regulator
HZT45_RS15855	COG0561	phosphatase activity
HZT45_RS15865	COG1737	Transcriptional regulator
HZT45_RS15870	COG1070	Carbohydrate kinase
HZT45_RS15895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZT45_RS15900	COG2186	Transcriptional regulator
HZT45_RS15905	COG1620	l-lactate permease
HZT45_RS15910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZT45_RS15920	COG5039	Polysaccharide pyruvyl transferase
HZT45_RS15925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZT45_RS15930	COG0110	maltose O-acetyltransferase activity
HZT45_RS15935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZT45_RS15940	COG2244	polysaccharide biosynthetic process
HZT45_RS15945	COG1216	Glycosyl transferase, family 2
HZT45_RS15950	COG5039	Polysaccharide pyruvyl transferase
HZT45_RS15955	COG1216	Glycosyl transferase, family 2
HZT45_RS15965	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS15970	COG1215	transferase activity, transferring glycosyl groups
HZT45_RS15975	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS15980	COG1086	Polysaccharide biosynthesis protein
HZT45_RS15985	COG0489	protein tyrosine kinase activity
HZT45_RS15990	COG3944	biosynthesis protein
HZT45_RS15995	COG1396	sequence-specific DNA binding
HZT45_RS16000	COG2272	Belongs to the type-B carboxylesterase lipase family
HZT45_RS16010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZT45_RS16015	COG2364	Membrane
HZT45_RS16020	COG0456	acetyltransferase
HZT45_RS16025	COG3479	Phenolic acid decarboxylase
HZT45_RS16065	COG2211	Major facilitator Superfamily
HZT45_RS16070	COG1609	Transcriptional regulator
HZT45_RS16080	COG0583	DNA-binding transcription factor activity
HZT45_RS16085	COG2828	Protein conserved in bacteria
HZT45_RS16090	COG2814	Major facilitator Superfamily
HZT45_RS16090	COG0477	Major facilitator Superfamily
HZT45_RS16095	COG1611	Belongs to the LOG family
HZT45_RS16100	COG1694	Mazg nucleotide pyrophosphohydrolase
HZT45_RS16105	COG0659	secondary active sulfate transmembrane transporter activity
HZT45_RS16110	COG0288	reversible hydration of carbon dioxide
HZT45_RS16115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZT45_RS16120	COG4290	ribonuclease
HZT45_RS16125	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HZT45_RS16130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS16140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZT45_RS16150	COG1051	belongs to the nudix hydrolase family
HZT45_RS16155	COG0492	ferredoxin-NADP+ reductase activity
HZT45_RS16160	COG3883	PFAM NLP P60 protein
HZT45_RS16160	COG0791	NLP P60 protein
HZT45_RS16170	COG0457	Tetratricopeptide repeat
HZT45_RS16175	COG5002	protein histidine kinase activity
HZT45_RS16180	COG0745	RESPONSE REGULATOR receiver
HZT45_RS16185	COG1132	(ABC) transporter
HZT45_RS16190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZT45_RS16190	COG0140	phosphoribosyl-ATP diphosphatase activity
HZT45_RS16215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZT45_RS16230	COG4990	cell redox homeostasis
HZT45_RS16235	COG0110	maltose O-acetyltransferase activity
HZT45_RS16255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZT45_RS16265	COG2188	Transcriptional regulator
HZT45_RS16270	COG1309	transcriptional regulator
HZT45_RS16275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZT45_RS16280	COG1950	PFAM Membrane protein of
HZT45_RS16285	COG1983	PspC domain protein
HZT45_RS16290	COG3595	metallopeptidase activity
HZT45_RS16305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZT45_RS16315	COG4897	Protein conserved in bacteria
HZT45_RS16320	COG3848	Pyruvate phosphate dikinase
HZT45_RS16320	COG0574	Belongs to the PEP-utilizing enzyme family
HZT45_RS16325	COG1309	transcriptional regulator
HZT45_RS16330	COG2814	Major facilitator Superfamily
HZT45_RS16340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT45_RS16350	COG3409	Peptidoglycan-binding domain 1 protein
HZT45_RS16350	COG0793	Belongs to the peptidase S41A family
HZT45_RS16355	COG3420	alginic acid biosynthetic process
HZT45_RS16360	COG2177	Part of the ABC transporter FtsEX involved in
HZT45_RS16365	COG2884	Cell division ATP-binding protein ftsE
HZT45_RS16370	COG2010	Cytochrome c
HZT45_RS16375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS16390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZT45_RS16405	COG1516	flagellar protein fliS
HZT45_RS16410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZT45_RS16415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZT45_RS16435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZT45_RS16440	COG4786	Flagellar basal body rod
HZT45_RS16440	COG1256	bacterial-type flagellum assembly
HZT45_RS16445	COG3418	PFAM FlgN family protein
HZT45_RS16450	COG2747	anti-sigma28 factor FlgM
HZT45_RS16460	COG1040	competence protein
HZT45_RS16470	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HZT45_RS16475	COG1307	EDD domain protein, DegV family
HZT45_RS16480	COG2197	response regulator
HZT45_RS16485	COG4585	Histidine kinase
HZT45_RS16490	COG1739	Uncharacterized protein family UPF0029
HZT45_RS16495	COG1316	TRANSCRIPTIONal
HZT45_RS16500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZT45_RS16505	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS16510	COG1215	transferase activity, transferring glycosyl groups
HZT45_RS16515	COG3206	protein involved in exopolysaccharide biosynthesis
HZT45_RS16520	COG3307	-O-antigen
HZT45_RS16525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZT45_RS16530	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS16530	COG0297	glycogen (starch) synthase activity
HZT45_RS16535	COG2244	polysaccharide biosynthetic process
HZT45_RS16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZT45_RS16545	COG2247	cell wall binding repeat
HZT45_RS16550	COG2385	sporulation resulting in formation of a cellular spore
HZT45_RS16550	COG2247	cell wall binding repeat
HZT45_RS16560	COG1316	TRANSCRIPTIONal
HZT45_RS16565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZT45_RS16570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZT45_RS16575	COG1134	teichoic acid transport
HZT45_RS16580	COG1682	transport, permease protein
HZT45_RS16585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZT45_RS16595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZT45_RS16600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZT45_RS16605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZT45_RS16610	COG4193	domain, Protein
HZT45_RS16615	COG1482	cell wall glycoprotein biosynthetic process
HZT45_RS16620	COG0697	spore germination
HZT45_RS16625	COG0814	amino acid
HZT45_RS16635	COG1215	transferase activity, transferring glycosyl groups
HZT45_RS16640	COG2814	Major facilitator Superfamily
HZT45_RS16645	COG1316	TRANSCRIPTIONal
HZT45_RS16650	COG0561	phosphatase activity
HZT45_RS16655	COG2433	Pfam Transposase IS66
HZT45_RS16660	COG0791	NLP P60 protein
HZT45_RS16670	COG2843	Capsule synthesis protein
HZT45_RS16680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZT45_RS16685	COG0697	spore germination
HZT45_RS16690	COG0814	amino acid
HZT45_RS16700	COG1609	Transcriptional regulator
HZT45_RS16705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZT45_RS16715	COG1129	ABC transporter
HZT45_RS16720	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZT45_RS16725	COG1879	ABC-type sugar transport system periplasmic component
HZT45_RS16730	COG3103	Sh3 type 3 domain protein
HZT45_RS16735	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZT45_RS16740	COG3527	Alpha-acetolactate decarboxylase
HZT45_RS16745	COG0028	Belongs to the TPP enzyme family
HZT45_RS16750	COG0583	DNA-binding transcription factor activity
HZT45_RS16755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZT45_RS16770	COG5337	Spore coat protein CotH
HZT45_RS16780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZT45_RS16790	COG0405	Gamma-glutamyltransferase
HZT45_RS16795	COG1522	sequence-specific DNA binding
HZT45_RS16800	COG2059	Chromate
HZT45_RS16805	COG2059	Chromate
HZT45_RS16850	COG5444	nuclease activity
HZT45_RS16865	COG3878	Protein conserved in bacteria
HZT45_RS16870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZT45_RS16875	COG4464	protein tyrosine phosphatase activity
HZT45_RS16880	COG0489	protein tyrosine kinase activity
HZT45_RS16885	COG3944	biosynthesis protein
HZT45_RS16895	COG4715	Zinc finger, swim domain protein
HZT45_RS16900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZT45_RS16905	COG0561	phosphatase activity
HZT45_RS16910	COG1349	DNA-binding transcription factor activity
HZT45_RS16915	COG0629	single-stranded DNA binding
HZT45_RS16940	COG0457	Tetratricopeptide repeat
HZT45_RS16945	COG4786	Flagellar basal body rod
HZT45_RS16950	COG4786	Flagellar basal body rod
HZT45_RS16955	COG1077	Cell shape determining protein MreB Mrl
HZT45_RS16960	COG1609	Transcriptional regulator
HZT45_RS16965	COG1846	Transcriptional regulator
HZT45_RS16970	COG2814	Major facilitator Superfamily
HZT45_RS16975	COG1953	Uracil, thiamine, allantoin
HZT45_RS16980	COG0477	Major facilitator Superfamily
HZT45_RS16985	COG1335	isochorismatase
HZT45_RS16990	COG0004	ammonium transporteR
HZT45_RS16995	COG0347	Belongs to the P(II) protein family
HZT45_RS17000	COG0772	Belongs to the SEDS family
HZT45_RS17005	COG0671	phosphoesterase, PA-phosphatase related
HZT45_RS17015	COG0739	heme binding
HZT45_RS17020	COG1247	-acetyltransferase
HZT45_RS17035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZT45_RS17045	COG0726	polysaccharide deacetylase
HZT45_RS17050	COG1959	2 iron, 2 sulfur cluster binding
HZT45_RS17065	COG0831	urea catabolic process
HZT45_RS17070	COG3237	CsbD-like
HZT45_RS17075	COG1994	Peptidase M50
HZT45_RS17080	COG0457	Tetratricopeptide repeat
HZT45_RS17090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZT45_RS17100	COG2304	oxidoreductase activity
HZT45_RS17105	COG2304	oxidoreductase activity
HZT45_RS17110	COG2385	sporulation resulting in formation of a cellular spore
HZT45_RS17115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZT45_RS17125	COG4836	Membrane
HZT45_RS17195	COG0698	ribose 5-phosphate isomerase
HZT45_RS17200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZT45_RS17210	COG0009	L-threonylcarbamoyladenylate synthase
HZT45_RS17215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZT45_RS17235	COG2890	protein-(glutamine-N5) methyltransferase activity
HZT45_RS17240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZT45_RS17245	COG0346	lactoylglutathione lyase activity
HZT45_RS17250	COG0789	Transcriptional regulator
HZT45_RS17255	COG0679	Auxin Efflux Carrier
HZT45_RS17260	COG0281	malic enzyme
HZT45_RS17275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZT45_RS17280	COG1494	fructose-1,6-bisphosphatase
HZT45_RS17285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZT45_RS17295	COG0191	fructose-bisphosphate aldolase activity
HZT45_RS17300	COG2204	response regulator
HZT45_RS17305	COG4821	SIS domain
HZT45_RS17320	COG2181	nitrate reductase activity
HZT45_RS17320	COG0247	lactate metabolic process
HZT45_RS17325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZT45_RS17340	COG1132	(ABC) transporter
HZT45_RS17345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZT45_RS17355	COG2181	nitrate reductase activity
HZT45_RS17360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZT45_RS17365	COG1140	nitrate reductase beta subunit
HZT45_RS17370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZT45_RS17375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT45_RS17385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZT45_RS17390	COG2223	nitrite transmembrane transporter activity
HZT45_RS17400	COG4506	Protein conserved in bacteria
HZT45_RS17410	COG3391	amine dehydrogenase activity
HZT45_RS17415	COG3391	amine dehydrogenase activity
HZT45_RS17420	COG0457	Tetratricopeptide repeat
HZT45_RS17460	COG0010	Belongs to the arginase family
HZT45_RS17465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZT45_RS17470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZT45_RS17485	COG1994	Peptidase M50
HZT45_RS17490	COG1942	4-Oxalocrotonate Tautomerase
HZT45_RS17495	COG1846	Transcriptional regulator
HZT45_RS17500	COG0531	amino acid
HZT45_RS17505	COG3465	dGTPase activity
HZT45_RS17510	COG1078	dGTPase activity
HZT45_RS17525	COG1695	Transcriptional regulator
HZT45_RS17535	COG1131	(ABC) transporter
HZT45_RS17540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZT45_RS17570	COG0583	DNA-binding transcription factor activity
HZT45_RS17580	COG0280	phosphate acetyltransferase
HZT45_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS17595	COG0436	Aminotransferase
HZT45_RS17625	COG2814	Major facilitator Superfamily
HZT45_RS17630	COG2814	Major facilitator Superfamily
HZT45_RS17635	COG0833	amino acid
HZT45_RS17640	COG4187	Peptidase family M20/M25/M40
HZT45_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS17650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZT45_RS17655	COG2205	protein histidine kinase activity
HZT45_RS17660	COG0745	RESPONSE REGULATOR receiver
HZT45_RS17675	COG1131	(ABC) transporter
HZT45_RS17680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HZT45_RS17685	COG1091	dTDP-4-dehydrorhamnose reductase activity
HZT45_RS17690	COG1088	dTDP-glucose 4,6-dehydratase activity
HZT45_RS17695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZT45_RS17700	COG3980	spore coat polysaccharide biosynthesis protein
HZT45_RS17705	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HZT45_RS17710	COG2089	acid synthase
HZT45_RS17715	COG0456	acetyltransferase
HZT45_RS17720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZT45_RS17725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZT45_RS17730	COG0463	Glycosyl transferase, family 2
HZT45_RS17740	COG2363	Small membrane protein
HZT45_RS17745	COG2233	PERMEase
HZT45_RS17760	COG1216	Glycosyl transferase, family 2
HZT45_RS17775	COG1695	Transcriptional regulator
HZT45_RS17780	COG0351	phosphomethylpyrimidine kinase
HZT45_RS17790	COG1621	beta-fructofuranosidase activity
HZT45_RS17795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS17795	COG1263	PTS System
HZT45_RS17800	COG3711	transcriptional antiterminator
HZT45_RS17810	COG1404	Belongs to the peptidase S8 family
HZT45_RS17815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZT45_RS17820	COG0778	Nitroreductase
HZT45_RS17825	COG0772	Belongs to the SEDS family
HZT45_RS17830	COG0454	-acetyltransferase
HZT45_RS17850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZT45_RS17855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZT45_RS17860	COG2261	transglycosylase associated protein
HZT45_RS17865	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZT45_RS17875	COG2246	polysaccharide biosynthetic process
HZT45_RS17880	COG1309	transcriptional regulator
HZT45_RS17900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZT45_RS17905	COG2837	iron assimilation
HZT45_RS17910	COG2822	iron ion transport
HZT45_RS17925	COG0583	DNA-binding transcription factor activity
HZT45_RS17935	COG1346	cytolysis
HZT45_RS17940	COG4895	conserved protein (DUF2196)
HZT45_RS17945	COG0789	Transcriptional regulator
HZT45_RS17950	COG5504	Zn-dependent protease
HZT45_RS17955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZT45_RS17960	COG0346	lactoylglutathione lyase activity
HZT45_RS17965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS17970	COG1404	Belongs to the peptidase S8 family
HZT45_RS17975	COG1442	glycosyl transferase family 8
HZT45_RS17980	COG2357	RelA SpoT domain protein
HZT45_RS17985	COG1575	Belongs to the MenA family. Type 1 subfamily
HZT45_RS18000	COG1696	Membrane protein involved in D-alanine export
HZT45_RS18010	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HZT45_RS18015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZT45_RS18020	COG1486	melibiose metabolic process
HZT45_RS18025	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZT45_RS18030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS18035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS18040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZT45_RS18040	COG3711	transcriptional antiterminator
HZT45_RS18050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS18055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZT45_RS18065	COG0640	Transcriptional regulator
HZT45_RS18070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZT45_RS18075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS18080	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZT45_RS18085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZT45_RS18090	COG2723	6-phospho-beta-galactosidase activity
HZT45_RS18095	COG1940	carbohydrate kinase activity
HZT45_RS18100	COG1482	cell wall glycoprotein biosynthetic process
HZT45_RS18110	COG0753	catalase activity
HZT45_RS18115	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HZT45_RS18120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZT45_RS18125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZT45_RS18130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZT45_RS18135	COG4988	ABC transporter
HZT45_RS18140	COG1294	oxidase, subunit
HZT45_RS18145	COG1271	oxidase subunit
HZT45_RS18150	COG3493	citrate carrier protein
HZT45_RS18155	COG0726	polysaccharide deacetylase
HZT45_RS18160	COG3842	ATPase activity
HZT45_RS18165	COG2508	Transcriptional regulator
HZT45_RS18170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS18180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZT45_RS18195	COG4894	glucomannan catabolic process
HZT45_RS18200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZT45_RS18205	COG0500	methyltransferase
HZT45_RS18210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZT45_RS18230	COG0753	catalase activity
HZT45_RS18230	COG0693	protein deglycase activity
HZT45_RS18235	COG2851	Citrate transporter
HZT45_RS18240	COG2273	Hydrolase Family 16
HZT45_RS18245	COG3711	transcriptional antiterminator
HZT45_RS18250	COG2270	Major facilitator Superfamily
HZT45_RS18255	COG0513	Belongs to the DEAD box helicase family
HZT45_RS18320	COG0697	spore germination
HZT45_RS18325	COG0589	response to stress
HZT45_RS18330	COG2723	6-phospho-beta-galactosidase activity
HZT45_RS18335	COG1263	PTS System
HZT45_RS18335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZT45_RS18335	COG2190	(PTS) system
HZT45_RS18365	COG3507	Belongs to the glycosyl hydrolase 43 family
HZT45_RS18390	COG0010	Belongs to the arginase family
HZT45_RS18395	COG0833	amino acid
HZT45_RS18400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HZT45_RS18405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZT45_RS18415	COG2390	Transcriptional regulator
HZT45_RS18420	COG0561	phosphatase activity
HZT45_RS18450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZT45_RS18455	COG5294	Protein conserved in bacteria
HZT45_RS18460	COG0577	efflux transmembrane transporter activity
HZT45_RS18465	COG1136	(ABC) transporter
HZT45_RS18470	COG2205	protein histidine kinase activity
HZT45_RS18475	COG0745	RESPONSE REGULATOR receiver
HZT45_RS18490	COG1082	Xylose isomerase domain protein TIM barrel
HZT45_RS18500	COG2814	Major facilitator Superfamily
HZT45_RS18530	COG1349	DNA-binding transcription factor activity
HZT45_RS18535	COG0667	Aldo Keto reductase
HZT45_RS18540	COG2814	Major facilitator Superfamily
HZT45_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS18555	COG2197	response regulator
HZT45_RS18560	COG4585	Histidine kinase
HZT45_RS18565	COG3239	Fatty acid desaturase
HZT45_RS18570	COG1309	transcriptional regulator
HZT45_RS18575	COG1012	belongs to the aldehyde dehydrogenase family
HZT45_RS18580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZT45_RS18590	COG0640	Transcriptional regulator
HZT45_RS18595	COG2814	Major facilitator Superfamily
HZT45_RS18600	COG1714	RDD family
HZT45_RS18610	COG0450	alkyl hydroperoxide reductase
HZT45_RS18615	COG3634	alkyl hydroperoxide reductase activity
HZT45_RS18620	COG3177	Filamentation induced by cAMP protein fic
HZT45_RS18625	COG1113	amino acid transport
HZT45_RS18635	COG2080	2 iron, 2 sulfur cluster binding
HZT45_RS18650	COG2068	MobA-Related Protein
HZT45_RS18655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZT45_RS18705	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HZT45_RS18710	COG0667	Aldo Keto reductase
HZT45_RS18715	COG0456	acetyltransferase
HZT45_RS18720	COG0457	Tetratricopeptide repeat
HZT45_RS18725	COG0010	Belongs to the arginase family
HZT45_RS18730	COG0833	amino acid
HZT45_RS18735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZT45_RS18740	COG3829	transcription factor binding
HZT45_RS18750	COG0488	(ABC) transporter
HZT45_RS18765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZT45_RS18770	COG5002	protein histidine kinase activity
HZT45_RS18770	COG3850	Histidine kinase
HZT45_RS18780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZT45_RS18785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZT45_RS18790	COG4853	Protein conserved in bacteria
HZT45_RS18795	COG4863	YycH protein
HZT45_RS18800	COG5002	protein histidine kinase activity
HZT45_RS18805	COG0745	RESPONSE REGULATOR receiver
HZT45_RS18835	COG0346	lactoylglutathione lyase activity
HZT45_RS18840	COG0305	Participates in initiation and elongation during chromosome replication
HZT45_RS18855	COG3093	addiction module antidote protein HigA
HZT45_RS18860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZT45_RS18875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZT45_RS18880	COG0438	transferase activity, transferring glycosyl groups
HZT45_RS18900	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HZT45_RS18905	COG4241	membrane
HZT45_RS18915	COG5577	PFAM Coat F domain
HZT45_RS18920	COG1733	regulation of RNA biosynthetic process
HZT45_RS18930	COG0697	spore germination
HZT45_RS18935	COG1621	beta-fructofuranosidase activity
HZT45_RS18940	COG1621	beta-fructofuranosidase activity
HZT45_RS18945	COG1802	Transcriptional regulator
HZT45_RS18950	COG2318	DinB family
HZT45_RS18955	COG2211	Major facilitator Superfamily
HZT45_RS18960	COG0583	DNA-binding transcription factor activity
HZT45_RS18970	COG2814	Major facilitator Superfamily
HZT45_RS18975	COG0583	DNA-binding transcription factor activity
HZT45_RS18985	COG0778	Nitroreductase
HZT45_RS18990	COG1846	Transcriptional regulator
HZT45_RS18995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZT45_RS19000	COG1846	Transcriptional regulator
HZT45_RS19005	COG2153	protein acetylation
HZT45_RS19015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZT45_RS19020	COG0583	DNA-binding transcription factor activity
HZT45_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
HZT45_RS19035	COG1331	Highly conserved protein containing a thioredoxin domain
HZT45_RS19040	COG5293	efflux transmembrane transporter activity
HZT45_RS19050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZT45_RS19065	COG1266	CAAX protease self-immunity
HZT45_RS19070	COG2814	Major facilitator Superfamily
HZT45_RS19070	COG0477	Major facilitator Superfamily
HZT45_RS19075	COG0346	lactoylglutathione lyase activity
HZT45_RS19080	COG1609	Transcriptional regulator
HZT45_RS19085	COG0708	Exodeoxyribonuclease III
HZT45_RS19090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZT45_RS19095	COG2169	Transcriptional regulator
HZT45_RS19105	COG0629	single-stranded DNA binding
HZT45_RS19115	COG0012	GTP binding
HZT45_RS19120	COG0243	molybdopterin cofactor binding
HZT45_RS19125	COG4481	Protein conserved in bacteria
HZT45_RS19130	COG3949	Membrane
HZT45_RS19145	COG1475	DNA binding
HZT45_RS19150	COG1192	Involved in chromosome partitioning
HZT45_RS19175	COG1847	R3H domain protein
HZT45_RS19180	COG0706	membrane insertase activity