locus-tag	class	description
GWK37_RS00005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWK37_RS00015	COG1278	Cold shock
GWK37_RS00035	COG0328	RNA-DNA hybrid ribonuclease activity
GWK37_RS00040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWK37_RS00045	COG0328	RNA-DNA hybrid ribonuclease activity
GWK37_RS00055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK37_RS00070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK37_RS00080	COG1755	Isoprenylcysteine carboxyl methyltransferase
GWK37_RS00085	COG3424	synthase
GWK37_RS00110	COG1335	isochorismatase
GWK37_RS00115	COG2233	PERMEase
GWK37_RS00125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWK37_RS00130	COG1199	ATP-dependent helicase activity
GWK37_RS00145	COG0116	Belongs to the methyltransferase superfamily
GWK37_RS00175	COG3359	exonuclease
GWK37_RS00180	COG1205	dead DEAH box helicase
GWK37_RS00180	COG1111	helicase
GWK37_RS00185	COG2190	(PTS) system
GWK37_RS00190	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK37_RS00230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK37_RS00230	COG4499	WXG100 protein secretion system (Wss), protein YukC
GWK37_RS00240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK37_RS00245	COG3935	DnaD domain protein
GWK37_RS00255	COG0436	Aminotransferase
GWK37_RS00260	COG5353	protein conserved in bacteria
GWK37_RS00270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK37_RS00270	COG1199	ATP-dependent helicase activity
GWK37_RS00300	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS00305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK37_RS00320	COG1694	Mazg nucleotide pyrophosphohydrolase
GWK37_RS00325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS00330	COG2140	Oxalate decarboxylase
GWK37_RS00340	COG4347	Protein of unknown function (DUF1405)
GWK37_RS00345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK37_RS00345	COG2010	Cytochrome c
GWK37_RS00350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK37_RS00355	COG0723	plastoquinol--plastocyanin reductase activity
GWK37_RS00370	COG0457	Tetratricopeptide repeat
GWK37_RS00380	COG0287	Prephenate dehydrogenase
GWK37_RS00415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK37_RS00420	COG4401	Chorismate mutase type I
GWK37_RS00435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWK37_RS00440	COG0105	UTP biosynthetic process
GWK37_RS00445	COG0142	geranyltranstransferase activity
GWK37_RS00455	COG0142	geranyltranstransferase activity
GWK37_RS00470	COG0776	regulation of translation
GWK37_RS00475	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GWK37_RS00515	COG0539	negative regulation of cytoplasmic translation
GWK37_RS00530	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GWK37_RS00535	COG2959	enzyme of heme biosynthesis
GWK37_RS00540	COG3773	Cell wall hydrolase
GWK37_RS00540	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS00545	COG2339	peptidase activity
GWK37_RS00550	COG0492	ferredoxin-NADP+ reductase activity
GWK37_RS00555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK37_RS00560	COG4862	establishment of competence for transformation
GWK37_RS00565	COG1408	metallophosphoesterase
GWK37_RS00575	COG1388	LysM domain
GWK37_RS00580	COG1266	CAAX protease self-immunity
GWK37_RS00585	COG0514	ATP-dependent DNA helicase (RecQ)
GWK37_RS00590	COG4955	Helix-turn-helix domain
GWK37_RS00595	COG1141	Ferredoxin
GWK37_RS00600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GWK37_RS00605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK37_RS00615	COG1595	DNA-templated transcription, initiation
GWK37_RS00620	COG5002	protein histidine kinase activity
GWK37_RS00625	COG0745	RESPONSE REGULATOR receiver
GWK37_RS00630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK37_RS00635	COG1333	cytochrome c biogenesis protein
GWK37_RS00640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS00645	COG1187	pseudouridine synthase activity
GWK37_RS00650	COG0700	Nucleoside recognition
GWK37_RS00655	COG2715	membrane protein required for spore maturation
GWK37_RS00660	COG1686	Belongs to the peptidase S11 family
GWK37_RS00685	COG1547	Domain of unknown function (DUF309)
GWK37_RS00690	COG0456	acetyltransferase
GWK37_RS00705	COG0307	riboflavin synthase, alpha
GWK37_RS00710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK37_RS00710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK37_RS00720	COG0681	Belongs to the peptidase S26 family
GWK37_RS00730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWK37_RS00735	COG4086	secreted protein
GWK37_RS00740	COG0019	diaminopimelate decarboxylase activity
GWK37_RS00745	COG0697	spore germination
GWK37_RS00760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK37_RS00780	COG1191	sigma factor activity
GWK37_RS00790	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS00795	COG1686	Belongs to the peptidase S11 family
GWK37_RS00800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GWK37_RS00805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWK37_RS00810	COG4974	Belongs to the 'phage' integrase family
GWK37_RS00820	COG0735	belongs to the Fur family
GWK37_RS00825	COG1300	Membrane
GWK37_RS00840	COG0281	malic enzyme
GWK37_RS00845	COG1757	Na H antiporter
GWK37_RS00850	COG1027	Aspartate ammonia-lyase
GWK37_RS00855	COG0252	asparaginase activity
GWK37_RS00860	COG1396	sequence-specific DNA binding
GWK37_RS00865	COG1379	DNA repair
GWK37_RS00870	COG0494	nUDIX hydrolase
GWK37_RS00880	COG0667	Aldo Keto reductase
GWK37_RS00890	COG1073	alpha beta
GWK37_RS00900	COG4918	Iron-sulphur cluster biosynthesis
GWK37_RS00905	COG0456	acetyltransferase
GWK37_RS00905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWK37_RS00910	COG2329	Antibiotic biosynthesis monooxygenase
GWK37_RS00915	COG0456	acetyltransferase
GWK37_RS00920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK37_RS00935	COG0628	permease
GWK37_RS00945	COG0346	lactoylglutathione lyase activity
GWK37_RS00955	COG3048	D-serine ammonia-lyase activity
GWK37_RS00960	COG0300	oxidoreductase activity
GWK37_RS00965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS00970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK37_RS00975	COG1024	Enoyl-CoA hydratase
GWK37_RS00980	COG3425	synthase
GWK37_RS00985	COG2124	cytochrome p450
GWK37_RS00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS00990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS00990	COG3321	synthase
GWK37_RS00990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS00995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS00995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS00995	COG3321	synthase
GWK37_RS00995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01000	COG0300	oxidoreductase activity
GWK37_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS01000	COG3321	synthase
GWK37_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01005	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS01005	COG3321	synthase
GWK37_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01005	COG0300	oxidoreductase activity
GWK37_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01010	COG3321	synthase
GWK37_RS01010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS01010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS01015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01015	COG3321	synthase
GWK37_RS01015	COG0300	oxidoreductase activity
GWK37_RS01020	COG3321	synthase
GWK37_RS01020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS01020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS01020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01025	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS01030	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS01045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK37_RS01045	COG2070	2-Nitropropane dioxygenase
GWK37_RS01050	COG0250	Participates in transcription elongation, termination and antitermination
GWK37_RS01075	COG0596	Alpha beta hydrolase
GWK37_RS01090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GWK37_RS01095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GWK37_RS01110	COG0706	membrane insertase activity
GWK37_RS01115	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK37_RS01120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK37_RS01125	COG0346	lactoylglutathione lyase activity
GWK37_RS01135	COG1376	ErfK ybiS ycfS ynhG family protein
GWK37_RS01140	COG4129	membrane
GWK37_RS01145	COG1126	abc transporter atp-binding protein
GWK37_RS01150	COG0765	amino acid transport
GWK37_RS01155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS01165	COG1597	lipid kinase activity
GWK37_RS01170	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK37_RS01175	COG0022	dehydrogenase e1 component
GWK37_RS01180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK37_RS01185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK37_RS01190	COG3426	butyrate kinase activity
GWK37_RS01195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK37_RS01200	COG0280	phosphate acetyltransferase
GWK37_RS01205	COG3829	transcription factor binding
GWK37_RS01205	COG3290	protein histidine kinase activity
GWK37_RS01215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWK37_RS01220	COG2079	MmgE PrpD family protein
GWK37_RS01225	COG0372	Belongs to the citrate synthase family
GWK37_RS01230	COG1960	acyl-CoA dehydrogenase activity
GWK37_RS01235	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK37_RS01240	COG0183	Belongs to the thiolase family
GWK37_RS01245	COG0584	glycerophosphoryl diester phosphodiesterase
GWK37_RS01250	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS01270	COG1902	pentaerythritol trinitrate reductase activity
GWK37_RS01285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWK37_RS01290	COG0745	RESPONSE REGULATOR receiver
GWK37_RS01295	COG0750	zinc metalloprotease
GWK37_RS01300	COG0497	DNA recombination
GWK37_RS01310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GWK37_RS01320	COG0142	geranyltranstransferase activity
GWK37_RS01330	COG1570	exodeoxyribonuclease VII activity
GWK37_RS01345	COG1302	Protein conserved in bacteria
GWK37_RS01350	COG0439	Biotin carboxylase
GWK37_RS01355	COG0511	ligase activity, forming carbon-carbon bonds
GWK37_RS01395	COG3854	ATPases associated with a variety of cellular activities
GWK37_RS01410	COG0006	proline dipeptidase activity
GWK37_RS01420	COG3872	metal-dependent enzyme
GWK37_RS01430	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK37_RS01445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK37_RS01465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK37_RS01480	COG1396	sequence-specific DNA binding
GWK37_RS01490	COG0681	Belongs to the peptidase S26 family
GWK37_RS01515	COG4940	Competence protein ComGF
GWK37_RS01525	COG4970	Tfp pilus assembly protein FimT
GWK37_RS01530	COG4537	Required for transformation and DNA binding
GWK37_RS01535	COG1459	type II secretion system
GWK37_RS01540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK37_RS01545	COG0598	Magnesium transport protein CorA
GWK37_RS01550	COG1253	flavin adenine dinucleotide binding
GWK37_RS01555	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS01565	COG1393	Belongs to the ArsC family
GWK37_RS01575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS01585	COG0011	TIGRFAM Protein of
GWK37_RS01595	COG2866	Carboxypeptidase
GWK37_RS01600	COG1940	carbohydrate kinase activity
GWK37_RS01605	COG4483	Protein conserved in bacteria
GWK37_RS01610	COG1757	Na H antiporter
GWK37_RS01620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWK37_RS01625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWK37_RS01635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK37_RS01640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK37_RS01645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK37_RS01650	COG0581	inorganic phosphate transmembrane transporter activity
GWK37_RS01655	COG0573	inorganic phosphate transmembrane transporter activity
GWK37_RS01660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK37_RS01670	COG0477	Major facilitator Superfamily
GWK37_RS01675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK37_RS01680	COG2839	Protein conserved in bacteria
GWK37_RS01685	COG5521	maltodextrose utilization protein MalA
GWK37_RS01690	COG1388	LysM domain
GWK37_RS01700	COG4709	membrane
GWK37_RS01705	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GWK37_RS01710	COG0735	belongs to the Fur family
GWK37_RS01715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS01730	COG0513	Belongs to the DEAD box helicase family
GWK37_RS01745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWK37_RS01750	COG2384	SAM-dependent methyltransferase
GWK37_RS01755	COG2010	Cytochrome c
GWK37_RS01760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWK37_RS01765	COG0358	DNA primase activity
GWK37_RS01780	COG0517	IMP dehydrogenase activity
GWK37_RS01785	COG0751	glycine-tRNA ligase activity
GWK37_RS01805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK37_RS01810	COG0295	cytidine deaminase activity
GWK37_RS01815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWK37_RS01825	COG1480	7TM receptor with intracellular HD hydrolase
GWK37_RS01830	COG1702	phosphate starvation-inducible protein PhoH
GWK37_RS01835	COG0561	phosphatase activity
GWK37_RS01850	COG4864	UPF0365 protein
GWK37_RS01855	COG1030	water channel activity
GWK37_RS01860	COG1610	YqeY-like protein
GWK37_RS01865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWK37_RS01870	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWK37_RS01875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK37_RS01880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK37_RS01910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK37_RS01925	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS01940	COG1466	dna polymerase III delta subunit
GWK37_RS01955	COG0658	competence protein
GWK37_RS01955	COG2333	competence protein COMEC
GWK37_RS01960	COG2131	deaminase
GWK37_RS01965	COG1555	photosystem II stabilization
GWK37_RS01965	COG1596	polysaccharide export
GWK37_RS01970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWK37_RS01975	COG2226	methyltransferase
GWK37_RS01980	COG0799	negative regulation of ribosome biogenesis
GWK37_RS01985	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWK37_RS01995	COG1534	Rna-binding protein
GWK37_RS02000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK37_RS02005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK37_RS02010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GWK37_RS02020	COG2755	lipolytic protein G-D-S-L family
GWK37_RS02025	COG0726	polysaccharide deacetylase
GWK37_RS02030	COG0398	Pfam SNARE associated Golgi protein
GWK37_RS02060	COG0583	DNA-binding transcription factor activity
GWK37_RS02075	COG0642	Histidine kinase
GWK37_RS02075	COG5002	protein histidine kinase activity
GWK37_RS02080	COG0745	RESPONSE REGULATOR receiver
GWK37_RS02085	COG2311	Membrane
GWK37_RS02095	COG0454	-acetyltransferase
GWK37_RS02100	COG0563	adenylate kinase activity
GWK37_RS02110	COG2814	Major facilitator Superfamily
GWK37_RS02120	COG0456	acetyltransferase
GWK37_RS02125	COG2318	DinB family
GWK37_RS02135	COG0561	phosphatase activity
GWK37_RS02140	COG0561	phosphatase activity
GWK37_RS02150	COG1482	cell wall glycoprotein biosynthetic process
GWK37_RS02155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK37_RS02155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS02155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK37_RS02160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS02160	COG3711	transcriptional antiterminator
GWK37_RS02170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWK37_RS02175	COG0583	DNA-binding transcription factor activity
GWK37_RS02180	COG2814	Major facilitator Superfamily
GWK37_RS02185	COG2124	cytochrome p450
GWK37_RS02185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWK37_RS02190	COG1309	transcriptional regulator
GWK37_RS02195	COG2226	methyltransferase
GWK37_RS02205	COG2116	formate transmembrane transporter activity
GWK37_RS02210	COG5609	conserved protein (DUF2294)
GWK37_RS02215	COG3383	formate dehydrogenase (NAD+) activity
GWK37_RS02220	COG2427	Protein of unknown function (DUF1641)
GWK37_RS02230	COG0626	cystathionine gamma-synthase activity
GWK37_RS02235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK37_RS02260	COG0768	penicillin binding
GWK37_RS02290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK37_RS02305	COG4472	Bacterial protein of unknown function (DUF965)
GWK37_RS02315	COG0628	permease
GWK37_RS02320	COG1126	abc transporter atp-binding protein
GWK37_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS02330	COG0765	amino acid transport
GWK37_RS02335	COG0765	amino acid transport
GWK37_RS02350	COG3881	PFAM PRC-barrel domain
GWK37_RS02355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK37_RS02360	COG0457	Tetratricopeptide repeat
GWK37_RS02370	COG1104	cysteine desulfurase activity
GWK37_RS02375	COG1959	2 iron, 2 sulfur cluster binding
GWK37_RS02380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWK37_RS02385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWK37_RS02410	COG4991	sh3 domain protein
GWK37_RS02410	COG3103	Sh3 type 3 domain protein
GWK37_RS02410	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK37_RS02430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWK37_RS02430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWK37_RS02435	COG5416	Lipopolysaccharide assembly protein A domain
GWK37_RS02440	COG0490	domain, Protein
GWK37_RS02445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK37_RS02445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK37_RS02455	COG2244	polysaccharide biosynthetic process
GWK37_RS02460	COG2323	membrane
GWK37_RS02470	COG1862	Preprotein translocase
GWK37_RS02515	COG1388	LysM domain
GWK37_RS02525	COG0157	Belongs to the NadC ModD family
GWK37_RS02530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWK37_RS02535	COG1104	cysteine desulfurase activity
GWK37_RS02540	COG1827	regulation of RNA biosynthetic process
GWK37_RS02545	COG0077	Prephenate dehydratase
GWK37_RS02560	COG3290	protein histidine kinase activity
GWK37_RS02565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWK37_RS02570	COG2868	ribosomal protein
GWK37_RS02580	COG1994	Peptidase M50
GWK37_RS02585	COG0739	heme binding
GWK37_RS02590	COG2894	cell division
GWK37_RS02600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWK37_RS02605	COG1792	Involved in formation and maintenance of cell shape
GWK37_RS02610	COG1077	Cell shape determining protein MreB Mrl
GWK37_RS02630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWK37_RS02635	COG0285	dihydrofolate synthase activity
GWK37_RS02640	COG0525	valine-tRNA ligase activity
GWK37_RS02650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK37_RS02655	COG1388	LysM domain
GWK37_RS02665	COG0113	porphobilinogen synthase activity
GWK37_RS02670	COG1587	Uroporphyrinogen-III synthase
GWK37_RS02680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWK37_RS02700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWK37_RS02705	COG1067	ATP-dependent peptidase activity
GWK37_RS02705	COG0470	DNA polymerase III
GWK37_RS02720	COG1477	protein flavinylation
GWK37_RS02720	COG0457	Tetratricopeptide repeat
GWK37_RS02735	COG0473	3-isopropylmalate dehydrogenase activity
GWK37_RS02750	COG0440	acetolactate synthase activity
GWK37_RS02755	COG0028	Belongs to the TPP enzyme family
GWK37_RS02785	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GWK37_RS02810	COG0622	Phosphoesterase
GWK37_RS02815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK37_RS02825	COG5401	PFAM Sporulation and spore germination
GWK37_RS02835	COG1846	Transcriptional regulator
GWK37_RS02840	COG2197	response regulator
GWK37_RS02845	COG0824	Thioesterase
GWK37_RS02850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK37_RS02855	COG1053	succinate dehydrogenase
GWK37_RS02860	COG2009	succinate dehydrogenase
GWK37_RS02865	COG1719	4-vinyl reductase, 4VR
GWK37_RS02870	COG0527	aspartate kinase activity
GWK37_RS02880	COG3118	belongs to the thioredoxin family
GWK37_RS02885	COG3534	alpha-L-arabinofuranosidase
GWK37_RS02890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWK37_RS02895	COG2086	electron transfer activity
GWK37_RS02900	COG1024	Enoyl-CoA hydratase
GWK37_RS02905	COG1309	transcriptional regulator
GWK37_RS02910	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS02920	COG3766	membrane
GWK37_RS02930	COG1796	DNA polymerase
GWK37_RS02930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK37_RS02935	COG1286	toxin biosynthetic process
GWK37_RS02950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK37_RS02950	COG0072	phenylalanine-tRNA ligase activity
GWK37_RS02955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWK37_RS02960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK37_RS02970	COG3835	regulator
GWK37_RS02975	COG0277	FAD linked oxidase domain protein
GWK37_RS02980	COG0247	lactate metabolic process
GWK37_RS02985	COG1966	Carbon starvation protein
GWK37_RS02990	COG3534	alpha-L-arabinofuranosidase
GWK37_RS02995	COG0395	ABC-type sugar transport system, permease component
GWK37_RS03000	COG1175	transmembrane transport
GWK37_RS03005	COG1653	transport
GWK37_RS03020	COG0235	Class ii aldolase
GWK37_RS03025	COG1069	ribulokinase activity
GWK37_RS03030	COG2160	L-arabinose isomerase activity
GWK37_RS03035	COG3507	Belongs to the glycosyl hydrolase 43 family
GWK37_RS03040	COG1363	Peptidase, m42
GWK37_RS03050	COG3326	Membrane
GWK37_RS03065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWK37_RS03070	COG1346	cytolysis
GWK37_RS03075	COG1380	Effector of murein hydrolase LrgA
GWK37_RS03080	COG3279	Response regulator of the LytR AlgR family
GWK37_RS03085	COG3275	phosphorelay sensor kinase activity
GWK37_RS03105	COG0398	Pfam SNARE associated Golgi protein
GWK37_RS03110	COG1484	DNA-dependent DNA replication
GWK37_RS03115	COG3611	Membrane attachment protein
GWK37_RS03130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK37_RS03135	COG1733	regulation of RNA biosynthetic process
GWK37_RS03140	COG2814	Major facilitator Superfamily
GWK37_RS03145	COG0656	L-ascorbic acid biosynthetic process
GWK37_RS03150	COG0237	dephospho-CoA kinase activity
GWK37_RS03155	COG1971	Probably functions as a manganese efflux pump
GWK37_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWK37_RS03165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK37_RS03165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK37_RS03170	COG5002	protein histidine kinase activity
GWK37_RS03175	COG0745	RESPONSE REGULATOR receiver
GWK37_RS03185	COG0538	isocitrate dehydrogenase activity
GWK37_RS03190	COG0372	Belongs to the citrate synthase family
GWK37_RS03195	COG0457	Tetratricopeptide repeat
GWK37_RS03220	COG0628	permease
GWK37_RS03225	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWK37_RS03230	COG0469	pyruvate kinase activity
GWK37_RS03250	COG0281	malic enzyme
GWK37_RS03255	COG0587	DNA-directed DNA polymerase activity
GWK37_RS03275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWK37_RS03285	COG4109	DRTGG domain
GWK37_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS03310	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK37_RS03320	COG0827	DNA restriction-modification system
GWK37_RS03325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GWK37_RS03330	COG3874	Sporulation protein YtfJ
GWK37_RS03340	COG1714	RDD family
GWK37_RS03345	COG0616	signal peptide processing
GWK37_RS03350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK37_RS03355	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GWK37_RS03360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK37_RS03375	COG1104	cysteine desulfurase activity
GWK37_RS03380	COG1114	Component of the transport system for branched-chain amino acids
GWK37_RS03390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK37_RS03395	COG1309	transcriptional regulator
GWK37_RS03400	COG1956	GAF domain-containing protein
GWK37_RS03405	COG2203	Gaf domain
GWK37_RS03405	COG2199	diguanylate cyclase activity
GWK37_RS03420	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS03425	COG4282	regulation of fungal-type cell wall biogenesis
GWK37_RS03450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK37_RS03450	COG1017	nitric oxide dioxygenase activity
GWK37_RS03460	COG0693	protein deglycase activity
GWK37_RS03475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWK37_RS03480	COG1378	Sugar-specific transcriptional regulator TrmB
GWK37_RS03500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK37_RS03505	COG0454	-acetyltransferase
GWK37_RS03510	COG0517	IMP dehydrogenase activity
GWK37_RS03515	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWK37_RS03520	COG1360	Flagellar Motor Protein
GWK37_RS03525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWK37_RS03530	COG1609	Transcriptional regulator
GWK37_RS03535	COG1605	Chorismate mutase
GWK37_RS03535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GWK37_RS03540	COG3118	belongs to the thioredoxin family
GWK37_RS03545	COG4980	gas vesicle protein
GWK37_RS03550	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GWK37_RS03560	COG1674	ftsk spoiiie
GWK37_RS03565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK37_RS03575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS03585	COG1363	Peptidase, m42
GWK37_RS03590	COG5584	Small secreted protein
GWK37_RS03595	COG0281	malic enzyme
GWK37_RS03600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS03615	COG0510	thiamine kinase activity
GWK37_RS03620	COG1597	lipid kinase activity
GWK37_RS03630	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GWK37_RS03635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK37_RS03640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK37_RS03645	COG2252	PERMEase
GWK37_RS03650	COG4473	ABC transporter
GWK37_RS03655	COG1131	(ABC) transporter
GWK37_RS03660	COG1349	DNA-binding transcription factor activity
GWK37_RS03665	COG1187	pseudouridine synthase activity
GWK37_RS03670	COG2244	polysaccharide biosynthetic process
GWK37_RS03675	COG2081	HI0933 family
GWK37_RS03680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK37_RS03710	COG1486	melibiose metabolic process
GWK37_RS03720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK37_RS03735	COG2202	Pas domain
GWK37_RS03735	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS03740	COG2814	Major facilitator Superfamily
GWK37_RS03745	COG5522	Integral membrane protein (intg_mem_TP0381)
GWK37_RS03750	COG0577	efflux transmembrane transporter activity
GWK37_RS03755	COG1136	(ABC) transporter
GWK37_RS03760	COG2205	protein histidine kinase activity
GWK37_RS03765	COG0745	RESPONSE REGULATOR receiver
GWK37_RS03770	COG0577	efflux transmembrane transporter activity
GWK37_RS03775	COG1136	(ABC) transporter
GWK37_RS03795	COG1131	(ABC) transporter
GWK37_RS03800	COG1725	Transcriptional regulator
GWK37_RS03815	COG0477	Major facilitator Superfamily
GWK37_RS03820	COG1242	4 iron, 4 sulfur cluster binding
GWK37_RS03825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GWK37_RS03835	COG0584	glycerophosphoryl diester phosphodiesterase
GWK37_RS03845	COG2267	carboxylic ester hydrolase activity
GWK37_RS03850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWK37_RS03855	COG1113	amino acid transport
GWK37_RS03860	COG0367	asparagine synthase
GWK37_RS03880	COG1506	peptidase
GWK37_RS03885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK37_RS03890	COG1116	anion transmembrane transporter activity
GWK37_RS03895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK37_RS03900	COG0494	nUDIX hydrolase
GWK37_RS03905	COG4824	toxin secretion phage lysis holin
GWK37_RS03910	COG0783	Belongs to the Dps family
GWK37_RS03935	COG0288	reversible hydration of carbon dioxide
GWK37_RS03945	COG1271	oxidase subunit
GWK37_RS03950	COG1294	oxidase, subunit
GWK37_RS03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK37_RS03965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK37_RS03965	COG1321	iron dependent repressor
GWK37_RS03970	COG1121	(ABC) transporter
GWK37_RS03975	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWK37_RS03980	COG4948	Mandelate Racemase Muconate Lactonizing
GWK37_RS03990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWK37_RS03995	COG0596	Alpha beta hydrolase
GWK37_RS04005	COG1169	isochorismate synthase
GWK37_RS04010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK37_RS04015	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GWK37_RS04140	COG3859	Proton-coupled thiamine transporter YuaJ
GWK37_RS04145	COG2268	Band 7 protein
GWK37_RS04150	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWK37_RS04155	COG2318	DinB family
GWK37_RS04165	COG1454	alcohol dehydrogenase
GWK37_RS04175	COG1510	regulation of RNA biosynthetic process
GWK37_RS04185	COG0569	domain protein
GWK37_RS04190	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWK37_RS04195	COG1017	nitric oxide dioxygenase activity
GWK37_RS04195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK37_RS04220	COG0628	permease
GWK37_RS04225	COG0673	inositol 2-dehydrogenase activity
GWK37_RS04230	COG0693	protein deglycase activity
GWK37_RS04235	COG0840	transmembrane signaling receptor activity
GWK37_RS04240	COG0840	transmembrane signaling receptor activity
GWK37_RS04245	COG0840	transmembrane signaling receptor activity
GWK37_RS04250	COG0840	transmembrane signaling receptor activity
GWK37_RS04265	COG2070	2-Nitropropane dioxygenase
GWK37_RS04270	COG0432	Pfam Uncharacterised protein family UPF0047
GWK37_RS04275	COG0366	Alpha amylase catalytic
GWK37_RS04280	COG1253	flavin adenine dinucleotide binding
GWK37_RS04285	COG2738	Putative neutral zinc metallopeptidase
GWK37_RS04300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK37_RS04325	COG1335	isochorismatase
GWK37_RS04330	COG1979	alcohol dehydrogenase
GWK37_RS04335	COG1979	alcohol dehydrogenase
GWK37_RS04340	COG2155	Conserved Protein
GWK37_RS04345	COG1098	S1 RNA binding domain
GWK37_RS04350	COG0436	Aminotransferase
GWK37_RS04355	COG1522	sequence-specific DNA binding
GWK37_RS04360	COG2267	carboxylic ester hydrolase activity
GWK37_RS04370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWK37_RS04375	COG2205	protein histidine kinase activity
GWK37_RS04385	COG5018	Exonuclease
GWK37_RS04390	COG2814	Major facilitator Superfamily
GWK37_RS04395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK37_RS04400	COG3011	Protein conserved in bacteria
GWK37_RS04410	COG3290	protein histidine kinase activity
GWK37_RS04415	COG4565	transcriptional regulatory protein
GWK37_RS04445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK37_RS04445	COG2111	Na H antiporter
GWK37_RS04450	COG2111	Na H antiporter
GWK37_RS04455	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK37_RS04460	COG0651	ATP synthesis coupled electron transport
GWK37_RS04465	COG1863	multisubunit Na H antiporter MnhE subunit
GWK37_RS04470	COG2212	antiporter activity
GWK37_RS04475	COG1320	monovalent cation:proton antiporter activity
GWK37_RS04480	COG2050	protein possibly involved in aromatic compounds catabolism
GWK37_RS04485	COG2197	response regulator
GWK37_RS04490	COG4585	Histidine kinase
GWK37_RS04500	COG0142	geranyltranstransferase activity
GWK37_RS04515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWK37_RS04520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWK37_RS04525	COG1335	isochorismatase
GWK37_RS04530	COG5506	Protein of unknown function (DUF1694)
GWK37_RS04545	COG0628	permease
GWK37_RS04555	COG1418	mRNA catabolic process
GWK37_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS04570	COG1511	domain protein
GWK37_RS04575	COG0433	COG0433 Predicted ATPase
GWK37_RS04575	COG1674	ftsk spoiiie
GWK37_RS04580	COG4499	WXG100 protein secretion system (Wss), protein YukC
GWK37_RS04585	COG5417	Belongs to the EsaB family
GWK37_RS04590	COG4842	Belongs to the WXG100 family
GWK37_RS04595	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GWK37_RS04595	COG2508	Transcriptional regulator
GWK37_RS04600	COG0686	Belongs to the AlaDH PNT family
GWK37_RS04605	COG5634	Uncharacterized conserved protein (DUF2278)
GWK37_RS04610	COG3251	PFAM MbtH domain protein
GWK37_RS04615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS04620	COG1535	isochorismatase
GWK37_RS04620	COG3433	isochorismatase activity
GWK37_RS04625	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWK37_RS04630	COG1169	isochorismate synthase
GWK37_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS04640	COG2819	hydrolase of the alpha beta superfamily
GWK37_RS04645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWK37_RS04650	COG1268	BioY protein
GWK37_RS04655	COG2056	Na+-H+ antiporter family
GWK37_RS04665	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWK37_RS04670	COG3584	3D domain protein
GWK37_RS04685	COG1252	NADH dehydrogenase
GWK37_RS04715	COG1131	(ABC) transporter
GWK37_RS04735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS04740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GWK37_RS04745	COG0316	Belongs to the HesB IscA family
GWK37_RS04755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK37_RS04765	COG1252	NADH dehydrogenase
GWK37_RS04770	COG4837	Protein of unknown function (DUF1462)
GWK37_RS04775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWK37_RS04780	COG4946	Tricorn protease homolog
GWK37_RS04780	COG1506	peptidase
GWK37_RS04780	COG0823	Involved in the tonB-independent uptake of proteins
GWK37_RS04790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK37_RS04795	COG0460	homoserine dehydrogenase
GWK37_RS04800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK37_RS04805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK37_RS04810	COG0647	UMP catabolic process
GWK37_RS04815	COG2445	Protein of unknown function DUF86
GWK37_RS04820	COG4470	Protein conserved in bacteria
GWK37_RS04830	COG0739	heme binding
GWK37_RS04840	COG0737	Belongs to the 5'-nucleotidase family
GWK37_RS04845	COG0730	response to heat
GWK37_RS04850	COG1801	Protein of unknown function DUF72
GWK37_RS04865	COG2508	Transcriptional regulator
GWK37_RS04870	COG0457	Tetratricopeptide repeat
GWK37_RS04880	COG2814	Major facilitator Superfamily
GWK37_RS04885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK37_RS04890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK37_RS04895	COG2356	endonuclease I
GWK37_RS04900	COG3842	ATPase activity
GWK37_RS04905	COG2188	Transcriptional regulator
GWK37_RS04910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK37_RS04915	COG0395	ABC-type sugar transport system, permease component
GWK37_RS04920	COG1175	transmembrane transport
GWK37_RS04925	COG1653	transport
GWK37_RS04930	COG2222	sugar isomerase
GWK37_RS04935	COG0789	Transcriptional regulator
GWK37_RS04960	COG0322	excinuclease ABC activity
GWK37_RS04965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK37_RS04970	COG2226	methyltransferase
GWK37_RS04980	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS04985	COG0719	Fe-S assembly protein
GWK37_RS04990	COG0822	iron-sulfur transferase activity
GWK37_RS04995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK37_RS05000	COG0719	Fe-S assembly protein
GWK37_RS05005	COG0396	ATPase activity
GWK37_RS05015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK37_RS05020	COG1464	Belongs to the NlpA lipoprotein family
GWK37_RS05025	COG2011	ABC-type metal ion transport system permease component
GWK37_RS05030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK37_RS05040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS05045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GWK37_RS05060	COG1393	Belongs to the ArsC family
GWK37_RS05065	COG1960	acyl-CoA dehydrogenase activity
GWK37_RS05070	COG0183	Belongs to the thiolase family
GWK37_RS05075	COG1024	Enoyl-CoA hydratase
GWK37_RS05075	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK37_RS05090	COG0477	Major facilitator Superfamily
GWK37_RS05100	COG5577	PFAM Coat F domain
GWK37_RS05105	COG1846	Transcriptional regulator
GWK37_RS05110	COG0477	Major facilitator Superfamily
GWK37_RS05115	COG0583	DNA-binding transcription factor activity
GWK37_RS05135	COG1120	ATPase activity
GWK37_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS05155	COG0783	Belongs to the Dps family
GWK37_RS05160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK37_RS05165	COG0745	RESPONSE REGULATOR receiver
GWK37_RS05170	COG2770	Histidine kinase
GWK37_RS05170	COG2205	protein histidine kinase activity
GWK37_RS05180	COG1309	transcriptional regulator
GWK37_RS05185	COG0114	fumarate hydratase activity
GWK37_RS05195	COG0697	spore germination
GWK37_RS05200	COG0814	amino acid
GWK37_RS05210	COG2197	response regulator
GWK37_RS05215	COG4585	Histidine kinase
GWK37_RS05220	COG4758	membrane
GWK37_RS05225	COG3595	metallopeptidase activity
GWK37_RS05230	COG1842	Phage shock protein A
GWK37_RS05235	COG4758	membrane
GWK37_RS05240	COG2814	Major facilitator Superfamily
GWK37_RS05245	COG2096	Adenosyltransferase
GWK37_RS05250	COG1120	ATPase activity
GWK37_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS05260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK37_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS05270	COG3386	PFAM SMP-30 Gluconolaconase
GWK37_RS05275	COG2205	protein histidine kinase activity
GWK37_RS05280	COG0745	RESPONSE REGULATOR receiver
GWK37_RS05290	COG1191	sigma factor activity
GWK37_RS05300	COG2140	Oxalate decarboxylase
GWK37_RS05310	COG1120	ATPase activity
GWK37_RS05315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS05320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS05325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK37_RS05330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWK37_RS05335	COG0531	amino acid
GWK37_RS05345	COG1988	membrane-bound metal-dependent
GWK37_RS05350	COG1368	sulfuric ester hydrolase activity
GWK37_RS05355	COG1910	domain protein
GWK37_RS05360	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK37_RS05365	COG4149	molybdate abc transporter
GWK37_RS05370	COG2197	response regulator
GWK37_RS05380	COG1131	(ABC) transporter
GWK37_RS05390	COG0842	Transport permease protein
GWK37_RS05395	COG0656	L-ascorbic acid biosynthetic process
GWK37_RS05415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWK37_RS05420	COG3973	AAA domain
GWK37_RS05425	COG2860	membrane
GWK37_RS05435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWK37_RS05440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK37_RS05445	COG2217	Heavy metal translocating P-type atpase
GWK37_RS05450	COG2217	Heavy metal translocating P-type atpase
GWK37_RS05455	COG2608	mercury ion transmembrane transporter activity
GWK37_RS05460	COG1937	Protein conserved in bacteria
GWK37_RS05465	COG0673	inositol 2-dehydrogenase activity
GWK37_RS05475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK37_RS05480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWK37_RS05485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK37_RS05490	COG1126	abc transporter atp-binding protein
GWK37_RS05495	COG0765	amino acid transport
GWK37_RS05500	COG0765	amino acid transport
GWK37_RS05505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS05510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS05515	COG0454	-acetyltransferase
GWK37_RS05520	COG0583	DNA-binding transcription factor activity
GWK37_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS05530	COG2732	(Barnase) inhibitor
GWK37_RS05535	COG2732	(Barnase) inhibitor
GWK37_RS05550	COG0557	exoribonuclease II activity
GWK37_RS05555	COG1647	Serine aminopeptidase, S33
GWK37_RS05560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK37_RS05565	COG1476	TRANSCRIPTIONal
GWK37_RS05570	COG1396	sequence-specific DNA binding
GWK37_RS05575	COG1396	sequence-specific DNA binding
GWK37_RS05580	COG1733	regulation of RNA biosynthetic process
GWK37_RS05610	COG1174	glycine betaine transport
GWK37_RS05615	COG1732	Glycine betaine
GWK37_RS05620	COG1174	glycine betaine transport
GWK37_RS05625	COG1125	glycine betaine transport
GWK37_RS05625	COG0517	IMP dehydrogenase activity
GWK37_RS05630	COG1510	regulation of RNA biosynthetic process
GWK37_RS05635	COG1174	glycine betaine transport
GWK37_RS05640	COG1732	Glycine betaine
GWK37_RS05645	COG1174	glycine betaine transport
GWK37_RS05650	COG1125	glycine betaine transport
GWK37_RS05650	COG0517	IMP dehydrogenase activity
GWK37_RS05655	COG1510	regulation of RNA biosynthetic process
GWK37_RS05660	COG2095	MarC family integral membrane protein
GWK37_RS05665	COG3064	Membrane
GWK37_RS05670	COG4640	response to antibiotic
GWK37_RS05675	COG0456	acetyltransferase
GWK37_RS05725	COG0126	phosphoglycerate kinase activity
GWK37_RS05730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK37_RS05735	COG2390	Transcriptional regulator
GWK37_RS05740	COG2814	Major facilitator Superfamily
GWK37_RS05745	COG1609	Transcriptional regulator
GWK37_RS05750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK37_RS05755	COG0583	DNA-binding transcription factor activity
GWK37_RS05760	COG0697	spore germination
GWK37_RS05765	COG1113	amino acid transport
GWK37_RS05770	COG1737	Transcriptional regulator
GWK37_RS05775	COG1070	Carbohydrate kinase
GWK37_RS05805	COG2186	Transcriptional regulator
GWK37_RS05810	COG1620	l-lactate permease
GWK37_RS05815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWK37_RS05825	COG5039	Polysaccharide pyruvyl transferase
GWK37_RS05830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWK37_RS05835	COG0110	maltose O-acetyltransferase activity
GWK37_RS05840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK37_RS05845	COG2244	polysaccharide biosynthetic process
GWK37_RS05850	COG1216	Glycosyl transferase, family 2
GWK37_RS05855	COG5039	Polysaccharide pyruvyl transferase
GWK37_RS05860	COG1216	Glycosyl transferase, family 2
GWK37_RS05870	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS05875	COG1215	transferase activity, transferring glycosyl groups
GWK37_RS05880	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS05885	COG1086	Polysaccharide biosynthesis protein
GWK37_RS05890	COG0489	protein tyrosine kinase activity
GWK37_RS05895	COG3944	biosynthesis protein
GWK37_RS05900	COG1396	sequence-specific DNA binding
GWK37_RS05905	COG2272	Belongs to the type-B carboxylesterase lipase family
GWK37_RS05915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWK37_RS05920	COG2364	Membrane
GWK37_RS05925	COG0456	acetyltransferase
GWK37_RS05930	COG3479	Phenolic acid decarboxylase
GWK37_RS05980	COG2223	nitrite transmembrane transporter activity
GWK37_RS05985	COG1609	Transcriptional regulator
GWK37_RS05995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK37_RS06000	COG0366	Alpha amylase catalytic
GWK37_RS06005	COG1554	hydrolase, family 65, central catalytic
GWK37_RS06010	COG5521	maltodextrose utilization protein MalA
GWK37_RS06015	COG3833	ABC-type maltose transport systems, permease component
GWK37_RS06020	COG1175	transmembrane transport
GWK37_RS06025	COG2182	Extracellular solute-binding protein
GWK37_RS06030	COG0366	Alpha amylase catalytic
GWK37_RS06035	COG1609	Transcriptional regulator
GWK37_RS06040	COG1611	Belongs to the LOG family
GWK37_RS06045	COG1694	Mazg nucleotide pyrophosphohydrolase
GWK37_RS06050	COG0659	secondary active sulfate transmembrane transporter activity
GWK37_RS06055	COG0288	reversible hydration of carbon dioxide
GWK37_RS06060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK37_RS06065	COG4290	ribonuclease
GWK37_RS06070	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GWK37_RS06075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS06085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWK37_RS06095	COG1051	belongs to the nudix hydrolase family
GWK37_RS06100	COG0492	ferredoxin-NADP+ reductase activity
GWK37_RS06105	COG3883	PFAM NLP P60 protein
GWK37_RS06105	COG0791	NLP P60 protein
GWK37_RS06110	COG0457	Tetratricopeptide repeat
GWK37_RS06115	COG5002	protein histidine kinase activity
GWK37_RS06120	COG0745	RESPONSE REGULATOR receiver
GWK37_RS06130	COG1132	(ABC) transporter
GWK37_RS06135	COG0140	phosphoribosyl-ATP diphosphatase activity
GWK37_RS06135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK37_RS06160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK37_RS06175	COG4990	cell redox homeostasis
GWK37_RS06180	COG0110	maltose O-acetyltransferase activity
GWK37_RS06200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWK37_RS06215	COG1309	transcriptional regulator
GWK37_RS06220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK37_RS06225	COG1950	PFAM Membrane protein of
GWK37_RS06230	COG1983	PspC domain protein
GWK37_RS06235	COG3595	metallopeptidase activity
GWK37_RS06250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK37_RS06260	COG4897	Protein conserved in bacteria
GWK37_RS06265	COG3848	Pyruvate phosphate dikinase
GWK37_RS06265	COG0574	Belongs to the PEP-utilizing enzyme family
GWK37_RS06270	COG1309	transcriptional regulator
GWK37_RS06275	COG2814	Major facilitator Superfamily
GWK37_RS06290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK37_RS06300	COG0793	Belongs to the peptidase S41A family
GWK37_RS06300	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS06305	COG3420	alginic acid biosynthetic process
GWK37_RS06310	COG2177	Part of the ABC transporter FtsEX involved in
GWK37_RS06315	COG2884	Cell division ATP-binding protein ftsE
GWK37_RS06320	COG2010	Cytochrome c
GWK37_RS06325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS06340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWK37_RS06355	COG1516	flagellar protein fliS
GWK37_RS06360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWK37_RS06365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWK37_RS06385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWK37_RS06390	COG4786	Flagellar basal body rod
GWK37_RS06390	COG1256	bacterial-type flagellum assembly
GWK37_RS06395	COG3418	PFAM FlgN family protein
GWK37_RS06400	COG2747	anti-sigma28 factor FlgM
GWK37_RS06410	COG1040	competence protein
GWK37_RS06420	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GWK37_RS06425	COG1307	EDD domain protein, DegV family
GWK37_RS06430	COG2197	response regulator
GWK37_RS06435	COG4585	Histidine kinase
GWK37_RS06440	COG1739	Uncharacterized protein family UPF0029
GWK37_RS06445	COG1316	TRANSCRIPTIONal
GWK37_RS06450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWK37_RS06455	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS06460	COG1215	transferase activity, transferring glycosyl groups
GWK37_RS06465	COG3206	protein involved in exopolysaccharide biosynthesis
GWK37_RS06470	COG3307	-O-antigen
GWK37_RS06475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK37_RS06480	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS06480	COG0297	glycogen (starch) synthase activity
GWK37_RS06485	COG2244	polysaccharide biosynthetic process
GWK37_RS06495	COG2247	cell wall binding repeat
GWK37_RS06495	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS06500	COG2385	sporulation resulting in formation of a cellular spore
GWK37_RS06500	COG2247	cell wall binding repeat
GWK37_RS06510	COG1316	TRANSCRIPTIONal
GWK37_RS06515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWK37_RS06520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK37_RS06525	COG1134	teichoic acid transport
GWK37_RS06530	COG1682	transport, permease protein
GWK37_RS06535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK37_RS06545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWK37_RS06550	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GWK37_RS06555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK37_RS06560	COG4193	domain, Protein
GWK37_RS06565	COG1482	cell wall glycoprotein biosynthetic process
GWK37_RS06570	COG0697	spore germination
GWK37_RS06575	COG0814	amino acid
GWK37_RS06585	COG1215	transferase activity, transferring glycosyl groups
GWK37_RS06590	COG2814	Major facilitator Superfamily
GWK37_RS06595	COG1316	TRANSCRIPTIONal
GWK37_RS06600	COG0561	phosphatase activity
GWK37_RS06605	COG2433	Pfam Transposase IS66
GWK37_RS06610	COG0791	NLP P60 protein
GWK37_RS06620	COG2843	Capsule synthesis protein
GWK37_RS06630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWK37_RS06635	COG0697	spore germination
GWK37_RS06640	COG0814	amino acid
GWK37_RS06650	COG1609	Transcriptional regulator
GWK37_RS06655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK37_RS06665	COG1129	ABC transporter
GWK37_RS06670	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWK37_RS06675	COG1879	ABC-type sugar transport system periplasmic component
GWK37_RS06680	COG3103	Sh3 type 3 domain protein
GWK37_RS06685	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK37_RS06690	COG3527	Alpha-acetolactate decarboxylase
GWK37_RS06695	COG0028	Belongs to the TPP enzyme family
GWK37_RS06700	COG0583	DNA-binding transcription factor activity
GWK37_RS06705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK37_RS06720	COG5337	Spore coat protein CotH
GWK37_RS06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK37_RS06740	COG0405	Gamma-glutamyltransferase
GWK37_RS06745	COG1522	sequence-specific DNA binding
GWK37_RS06750	COG2059	Chromate
GWK37_RS06755	COG2059	Chromate
GWK37_RS06765	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK37_RS06770	COG0583	DNA-binding transcription factor activity
GWK37_RS06775	COG1515	deoxyribonuclease V activity
GWK37_RS06780	COG2849	repeat protein
GWK37_RS06785	COG5444	nuclease activity
GWK37_RS06800	COG3878	Protein conserved in bacteria
GWK37_RS06805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK37_RS06810	COG4464	protein tyrosine phosphatase activity
GWK37_RS06815	COG0489	protein tyrosine kinase activity
GWK37_RS06820	COG3944	biosynthesis protein
GWK37_RS06830	COG4715	Zinc finger, swim domain protein
GWK37_RS06835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWK37_RS06840	COG0561	phosphatase activity
GWK37_RS06845	COG1349	DNA-binding transcription factor activity
GWK37_RS06850	COG0629	single-stranded DNA binding
GWK37_RS06875	COG0457	Tetratricopeptide repeat
GWK37_RS06880	COG4786	Flagellar basal body rod
GWK37_RS06885	COG4786	Flagellar basal body rod
GWK37_RS06890	COG1077	Cell shape determining protein MreB Mrl
GWK37_RS06895	COG1609	Transcriptional regulator
GWK37_RS06900	COG1846	Transcriptional regulator
GWK37_RS06905	COG2814	Major facilitator Superfamily
GWK37_RS06910	COG1953	Uracil, thiamine, allantoin
GWK37_RS06915	COG0477	Major facilitator Superfamily
GWK37_RS06920	COG1335	isochorismatase
GWK37_RS06925	COG0004	ammonium transporteR
GWK37_RS06930	COG0347	Belongs to the P(II) protein family
GWK37_RS06935	COG0772	Belongs to the SEDS family
GWK37_RS06940	COG0671	phosphoesterase, PA-phosphatase related
GWK37_RS06950	COG0739	heme binding
GWK37_RS06955	COG1247	-acetyltransferase
GWK37_RS06970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK37_RS06980	COG0726	polysaccharide deacetylase
GWK37_RS06985	COG1959	2 iron, 2 sulfur cluster binding
GWK37_RS07000	COG0831	urea catabolic process
GWK37_RS07010	COG1994	Peptidase M50
GWK37_RS07015	COG0457	Tetratricopeptide repeat
GWK37_RS07025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK37_RS07030	COG2304	oxidoreductase activity
GWK37_RS07035	COG2304	oxidoreductase activity
GWK37_RS07040	COG2385	sporulation resulting in formation of a cellular spore
GWK37_RS07045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK37_RS07055	COG4836	Membrane
GWK37_RS07095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWK37_RS07125	COG0698	ribose 5-phosphate isomerase
GWK37_RS07130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK37_RS07140	COG0009	L-threonylcarbamoyladenylate synthase
GWK37_RS07145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWK37_RS07165	COG2890	protein-(glutamine-N5) methyltransferase activity
GWK37_RS07170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWK37_RS07175	COG0346	lactoylglutathione lyase activity
GWK37_RS07180	COG0789	Transcriptional regulator
GWK37_RS07185	COG0679	Auxin Efflux Carrier
GWK37_RS07190	COG0281	malic enzyme
GWK37_RS07200	COG0254	rRNA binding
GWK37_RS07205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWK37_RS07210	COG1494	fructose-1,6-bisphosphatase
GWK37_RS07215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK37_RS07225	COG0191	fructose-bisphosphate aldolase activity
GWK37_RS07230	COG2204	response regulator
GWK37_RS07235	COG4821	SIS domain
GWK37_RS07250	COG0247	lactate metabolic process
GWK37_RS07250	COG2181	nitrate reductase activity
GWK37_RS07255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK37_RS07270	COG1132	(ABC) transporter
GWK37_RS07275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK37_RS07285	COG2181	nitrate reductase activity
GWK37_RS07290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GWK37_RS07295	COG1140	nitrate reductase beta subunit
GWK37_RS07300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GWK37_RS07305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK37_RS07315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK37_RS07320	COG2223	nitrite transmembrane transporter activity
GWK37_RS07330	COG4506	Protein conserved in bacteria
GWK37_RS07335	COG0457	Tetratricopeptide repeat
GWK37_RS07375	COG0018	arginyl-trna synthetase
GWK37_RS07380	COG0010	Belongs to the arginase family
GWK37_RS07385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWK37_RS07390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK37_RS07405	COG1994	Peptidase M50
GWK37_RS07410	COG1942	4-Oxalocrotonate Tautomerase
GWK37_RS07415	COG1846	Transcriptional regulator
GWK37_RS07425	COG0531	amino acid
GWK37_RS07430	COG3465	dGTPase activity
GWK37_RS07435	COG1078	dGTPase activity
GWK37_RS07450	COG1695	Transcriptional regulator
GWK37_RS07460	COG1131	(ABC) transporter
GWK37_RS07465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWK37_RS07495	COG0583	DNA-binding transcription factor activity
GWK37_RS07505	COG0280	phosphate acetyltransferase
GWK37_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS07520	COG0436	Aminotransferase
GWK37_RS07550	COG2814	Major facilitator Superfamily
GWK37_RS07555	COG2814	Major facilitator Superfamily
GWK37_RS07560	COG0833	amino acid
GWK37_RS07565	COG4187	Peptidase family M20/M25/M40
GWK37_RS07570	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS07575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK37_RS07580	COG2205	protein histidine kinase activity
GWK37_RS07585	COG0745	RESPONSE REGULATOR receiver
GWK37_RS07600	COG1131	(ABC) transporter
GWK37_RS07605	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GWK37_RS07610	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWK37_RS07615	COG1088	dTDP-glucose 4,6-dehydratase activity
GWK37_RS07620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWK37_RS07625	COG3980	spore coat polysaccharide biosynthesis protein
GWK37_RS07630	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GWK37_RS07635	COG2089	acid synthase
GWK37_RS07640	COG0456	acetyltransferase
GWK37_RS07645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWK37_RS07650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWK37_RS07655	COG0463	Glycosyl transferase, family 2
GWK37_RS07665	COG2363	Small membrane protein
GWK37_RS07670	COG2233	PERMEase
GWK37_RS07685	COG1216	Glycosyl transferase, family 2
GWK37_RS07700	COG1695	Transcriptional regulator
GWK37_RS07705	COG0351	phosphomethylpyrimidine kinase
GWK37_RS07715	COG1621	beta-fructofuranosidase activity
GWK37_RS07720	COG1263	PTS System
GWK37_RS07720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS07725	COG3711	transcriptional antiterminator
GWK37_RS07735	COG1404	Belongs to the peptidase S8 family
GWK37_RS07740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK37_RS07745	COG0778	Nitroreductase
GWK37_RS07750	COG0772	Belongs to the SEDS family
GWK37_RS07755	COG0454	-acetyltransferase
GWK37_RS07775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK37_RS07780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK37_RS07785	COG2261	transglycosylase associated protein
GWK37_RS07790	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GWK37_RS07795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWK37_RS07800	COG2246	polysaccharide biosynthetic process
GWK37_RS07805	COG1309	transcriptional regulator
GWK37_RS07825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK37_RS07830	COG2837	iron assimilation
GWK37_RS07835	COG2822	iron ion transport
GWK37_RS07850	COG0583	DNA-binding transcription factor activity
GWK37_RS07860	COG1346	cytolysis
GWK37_RS07865	COG4895	conserved protein (DUF2196)
GWK37_RS07870	COG0789	Transcriptional regulator
GWK37_RS07875	COG5504	Zn-dependent protease
GWK37_RS07880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWK37_RS07885	COG0346	lactoylglutathione lyase activity
GWK37_RS07890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS07895	COG1404	Belongs to the peptidase S8 family
GWK37_RS07900	COG1442	glycosyl transferase family 8
GWK37_RS07905	COG1846	Transcriptional regulator
GWK37_RS07910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK37_RS07915	COG2357	RelA SpoT domain protein
GWK37_RS07920	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK37_RS07935	COG1696	Membrane protein involved in D-alanine export
GWK37_RS07945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GWK37_RS07950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS07955	COG1486	melibiose metabolic process
GWK37_RS07960	COG1447	Phosphotransferase system cellobiose-specific component IIA
GWK37_RS07965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS07970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS07975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS07975	COG3711	transcriptional antiterminator
GWK37_RS07985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS07990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS08000	COG0640	Transcriptional regulator
GWK37_RS08005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GWK37_RS08010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS08015	COG1447	Phosphotransferase system cellobiose-specific component IIA
GWK37_RS08020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS08025	COG2723	6-phospho-beta-galactosidase activity
GWK37_RS08030	COG1940	carbohydrate kinase activity
GWK37_RS08035	COG1482	cell wall glycoprotein biosynthetic process
GWK37_RS08045	COG0753	catalase activity
GWK37_RS08050	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GWK37_RS08055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK37_RS08060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK37_RS08065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWK37_RS08070	COG4988	ABC transporter
GWK37_RS08075	COG1294	oxidase, subunit
GWK37_RS08080	COG1271	oxidase subunit
GWK37_RS08085	COG3493	citrate carrier protein
GWK37_RS08090	COG0726	polysaccharide deacetylase
GWK37_RS08095	COG3842	ATPase activity
GWK37_RS08100	COG2508	Transcriptional regulator
GWK37_RS08105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS08115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK37_RS08125	COG4894	glucomannan catabolic process
GWK37_RS08130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWK37_RS08135	COG0500	methyltransferase
GWK37_RS08140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK37_RS08160	COG0693	protein deglycase activity
GWK37_RS08160	COG0753	catalase activity
GWK37_RS08165	COG2851	Citrate transporter
GWK37_RS08170	COG2273	Hydrolase Family 16
GWK37_RS08175	COG3711	transcriptional antiterminator
GWK37_RS08180	COG2270	Major facilitator Superfamily
GWK37_RS08185	COG0513	Belongs to the DEAD box helicase family
GWK37_RS08255	COG0697	spore germination
GWK37_RS08260	COG0589	response to stress
GWK37_RS08270	COG0494	nUDIX hydrolase
GWK37_RS08275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GWK37_RS08280	COG3507	Belongs to the glycosyl hydrolase 43 family
GWK37_RS08305	COG0010	Belongs to the arginase family
GWK37_RS08310	COG0833	amino acid
GWK37_RS08315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWK37_RS08320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWK37_RS08330	COG2390	Transcriptional regulator
GWK37_RS08335	COG0561	phosphatase activity
GWK37_RS08365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK37_RS08370	COG5294	Protein conserved in bacteria
GWK37_RS08375	COG0577	efflux transmembrane transporter activity
GWK37_RS08380	COG1136	(ABC) transporter
GWK37_RS08385	COG2205	protein histidine kinase activity
GWK37_RS08390	COG0745	RESPONSE REGULATOR receiver
GWK37_RS08395	COG2205	protein histidine kinase activity
GWK37_RS08400	COG0745	RESPONSE REGULATOR receiver
GWK37_RS08430	COG1082	Xylose isomerase domain protein TIM barrel
GWK37_RS08440	COG2814	Major facilitator Superfamily
GWK37_RS08470	COG1349	DNA-binding transcription factor activity
GWK37_RS08475	COG0667	Aldo Keto reductase
GWK37_RS08480	COG2814	Major facilitator Superfamily
GWK37_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS08500	COG2197	response regulator
GWK37_RS08505	COG4585	Histidine kinase
GWK37_RS08510	COG3239	Fatty acid desaturase
GWK37_RS08515	COG1309	transcriptional regulator
GWK37_RS08520	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS08525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWK37_RS08535	COG0640	Transcriptional regulator
GWK37_RS08540	COG2814	Major facilitator Superfamily
GWK37_RS08545	COG1714	RDD family
GWK37_RS08555	COG0501	Belongs to the peptidase M48B family
GWK37_RS08560	COG1715	Restriction endonuclease
GWK37_RS08565	COG0450	alkyl hydroperoxide reductase
GWK37_RS08570	COG3634	alkyl hydroperoxide reductase activity
GWK37_RS08575	COG3177	Filamentation induced by cAMP protein fic
GWK37_RS08580	COG1113	amino acid transport
GWK37_RS08590	COG2080	2 iron, 2 sulfur cluster binding
GWK37_RS08605	COG2068	MobA-Related Protein
GWK37_RS08610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWK37_RS08650	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GWK37_RS08655	COG0667	Aldo Keto reductase
GWK37_RS08660	COG0456	acetyltransferase
GWK37_RS08665	COG0457	Tetratricopeptide repeat
GWK37_RS08670	COG0010	Belongs to the arginase family
GWK37_RS08675	COG0833	amino acid
GWK37_RS08680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK37_RS08685	COG5658	integral membrane protein
GWK37_RS08690	COG0640	Transcriptional regulator
GWK37_RS08695	COG3829	transcription factor binding
GWK37_RS08705	COG0488	(ABC) transporter
GWK37_RS08720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK37_RS08725	COG3850	Histidine kinase
GWK37_RS08725	COG5002	protein histidine kinase activity
GWK37_RS08740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK37_RS08745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GWK37_RS08750	COG4853	Protein conserved in bacteria
GWK37_RS08755	COG4863	YycH protein
GWK37_RS08760	COG5002	protein histidine kinase activity
GWK37_RS08765	COG0745	RESPONSE REGULATOR receiver
GWK37_RS08795	COG0346	lactoylglutathione lyase activity
GWK37_RS08800	COG0305	Participates in initiation and elongation during chromosome replication
GWK37_RS08815	COG3093	addiction module antidote protein HigA
GWK37_RS08820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWK37_RS08825	COG0297	glycogen (starch) synthase activity
GWK37_RS08835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWK37_RS08840	COG0438	transferase activity, transferring glycosyl groups
GWK37_RS08850	COG2112	serine threonine protein kinase
GWK37_RS08860	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GWK37_RS08865	COG4241	membrane
GWK37_RS08875	COG5577	PFAM Coat F domain
GWK37_RS08880	COG1733	regulation of RNA biosynthetic process
GWK37_RS08890	COG0697	spore germination
GWK37_RS08895	COG1621	beta-fructofuranosidase activity
GWK37_RS08900	COG1621	beta-fructofuranosidase activity
GWK37_RS08905	COG1802	Transcriptional regulator
GWK37_RS08910	COG2318	DinB family
GWK37_RS08915	COG2211	Major facilitator Superfamily
GWK37_RS08920	COG0697	spore germination
GWK37_RS08930	COG0778	Nitroreductase
GWK37_RS08935	COG1846	Transcriptional regulator
GWK37_RS08940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS08945	COG1846	Transcriptional regulator
GWK37_RS08950	COG2153	protein acetylation
GWK37_RS08960	COG0546	phosphoglycolate phosphatase activity
GWK37_RS08990	COG1404	Belongs to the peptidase S8 family
GWK37_RS09000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS09005	COG0697	spore germination
GWK37_RS09010	COG1078	dGTPase activity
GWK37_RS09020	COG1331	Highly conserved protein containing a thioredoxin domain
GWK37_RS09025	COG1266	CAAX protease self-immunity
GWK37_RS09030	COG2814	Major facilitator Superfamily
GWK37_RS09030	COG0477	Major facilitator Superfamily
GWK37_RS09035	COG0346	lactoylglutathione lyase activity
GWK37_RS09040	COG1609	Transcriptional regulator
GWK37_RS09045	COG0708	Exodeoxyribonuclease III
GWK37_RS09050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK37_RS09055	COG2169	Transcriptional regulator
GWK37_RS09065	COG0629	single-stranded DNA binding
GWK37_RS09075	COG0012	GTP binding
GWK37_RS09080	COG0243	molybdopterin cofactor binding
GWK37_RS09085	COG4481	Protein conserved in bacteria
GWK37_RS09090	COG3949	Membrane
GWK37_RS09105	COG1475	DNA binding
GWK37_RS09110	COG1192	Involved in chromosome partitioning
GWK37_RS09135	COG1847	R3H domain protein
GWK37_RS09140	COG0706	membrane insertase activity
GWK37_RS09150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWK37_RS09160	COG0592	DNA-directed DNA polymerase activity
GWK37_RS09165	COG2501	S4 domain
GWK37_RS09180	COG0187	DNA topoisomerase II activity
GWK37_RS09185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK37_RS09220	COG0516	GMP reductase activity
GWK37_RS09220	COG0517	IMP dehydrogenase activity
GWK37_RS09225	COG1686	Belongs to the peptidase S11 family
GWK37_RS09245	COG1929	Belongs to the glycerate kinase type-1 family
GWK37_RS09255	COG1428	Deoxynucleoside kinase
GWK37_RS09260	COG1428	Deoxynucleoside kinase
GWK37_RS09265	COG3858	chitin binding
GWK37_RS09265	COG1388	LysM domain
GWK37_RS09270	COG1335	isochorismatase
GWK37_RS09275	COG0590	tRNA wobble adenosine to inosine editing
GWK37_RS09285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWK37_RS09290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWK37_RS09340	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GWK37_RS09345	COG3853	Toxic anion resistance protein (TelA)
GWK37_RS09350	COG1982	Orn Lys Arg decarboxylase major
GWK37_RS09360	COG3870	Protein conserved in bacteria
GWK37_RS09365	COG1728	Protein conserved in bacteria
GWK37_RS09370	COG0470	DNA polymerase III
GWK37_RS09375	COG1774	PSP1 C-terminal conserved region
GWK37_RS09385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWK37_RS09395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWK37_RS09400	COG2002	toxin-antitoxin pair type II binding
GWK37_RS09405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK37_RS09405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK37_RS09410	COG0084	hydrolase, TatD family'
GWK37_RS09415	COG3583	domain protein
GWK37_RS09415	COG3584	3D domain protein
GWK37_RS09420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GWK37_RS09425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK37_RS09435	COG4466	Protein conserved in bacteria
GWK37_RS09450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK37_RS09455	COG0251	oxidation-reduction process
GWK37_RS09470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK37_RS09490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK37_RS09495	COG2002	toxin-antitoxin pair type II binding
GWK37_RS09500	COG2244	polysaccharide biosynthetic process
GWK37_RS09505	COG3956	TIGRFAM MazG family protein
GWK37_RS09510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWK37_RS09525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWK37_RS09530	COG1098	S1 RNA binding domain
GWK37_RS09545	COG2208	phosphoserine phosphatase activity
GWK37_RS09550	COG2304	oxidoreductase activity
GWK37_RS09555	COG0515	serine threonine protein kinase
GWK37_RS09560	COG0037	tRNA processing
GWK37_RS09570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK37_RS09585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK37_RS09590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK37_RS09595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK37_RS09600	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK37_RS09605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS09610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK37_RS09615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWK37_RS09620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWK37_RS09625	COG1396	sequence-specific DNA binding
GWK37_RS09630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK37_RS09635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWK37_RS09715	COG4463	regulation of RNA biosynthetic process
GWK37_RS09720	COG3880	PFAM UvrB UvrC protein
GWK37_RS09730	COG0542	response to heat
GWK37_RS09735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWK37_RS09740	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GWK37_RS09745	COG4956	integral membrane protein (PIN domain superfamily)
GWK37_RS09765	COG1045	serine acetyltransferase
GWK37_RS09775	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GWK37_RS09780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK37_RS09785	COG3688	RNA-binding protein containing a PIN domain
GWK37_RS09790	COG1595	DNA-templated transcription, initiation
GWK37_RS09795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWK37_RS09800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWK37_RS09805	COG0250	Participates in transcription elongation, termination and antitermination
GWK37_RS09810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWK37_RS09825	COG0222	ribosome binding
GWK37_RS09830	COG2813	Specifically methylates the guanine in position
GWK37_RS09845	COG1358	cellular component organization or biogenesis
GWK37_RS09870	COG0596	Alpha beta hydrolase
GWK37_RS09875	COG0051	transcription antitermination factor activity, RNA binding
GWK37_RS09890	COG0089	rRNA binding
GWK37_RS09900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWK37_RS09905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWK37_RS09915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWK37_RS09920	COG0255	Belongs to the universal ribosomal protein uL29 family
GWK37_RS09970	COG1841	ribosomal large subunit assembly
GWK37_RS09980	COG0201	protein transport
GWK37_RS09990	COG0024	Methionine aminopeptidase
GWK37_RS10000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWK37_RS10005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWK37_RS10030	COG1122	ATPase activity
GWK37_RS10035	COG1122	ATPase activity
GWK37_RS10040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GWK37_RS10060	COG2226	methyltransferase
GWK37_RS10065	COG2318	DinB family
GWK37_RS10075	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS10080	COG0489	protein tyrosine kinase activity
GWK37_RS10090	COG2194	sulfuric ester hydrolase activity
GWK37_RS10095	COG0726	polysaccharide deacetylase
GWK37_RS10155	COG0738	Major facilitator superfamily
GWK37_RS10160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS10175	COG0659	secondary active sulfate transmembrane transporter activity
GWK37_RS10180	COG0385	Bile acid
GWK37_RS10185	COG2819	hydrolase of the alpha beta superfamily
GWK37_RS10190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS10195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS10200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK37_RS10205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK37_RS10205	COG2207	Transcriptional regulator
GWK37_RS10210	COG3876	Protein conserved in bacteria
GWK37_RS10215	COG1472	Belongs to the glycosyl hydrolase 3 family
GWK37_RS10220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK37_RS10225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS10225	COG1263	PTS System
GWK37_RS10235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS10240	COG1683	Conserved Protein
GWK37_RS10270	COG1595	DNA-templated transcription, initiation
GWK37_RS10275	COG5662	AntiSigma factor
GWK37_RS10280	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWK37_RS10285	COG4856	YbbR-like protein
GWK37_RS10325	COG1346	cytolysis
GWK37_RS10330	COG1380	Effector of murein hydrolase LrgA
GWK37_RS10335	COG1846	Transcriptional regulator
GWK37_RS10340	COG1113	amino acid transport
GWK37_RS10345	COG1011	Hydrolase
GWK37_RS10350	COG4585	Histidine kinase
GWK37_RS10355	COG2197	response regulator
GWK37_RS10360	COG1131	(ABC) transporter
GWK37_RS10380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GWK37_RS10400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS10400	COG4221	oxidoreductase activity
GWK37_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS10400	COG3321	synthase
GWK37_RS10405	COG0300	oxidoreductase activity
GWK37_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS10405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS10405	COG3321	synthase
GWK37_RS10445	COG0531	amino acid
GWK37_RS10465	COG0584	glycerophosphoryl diester phosphodiesterase
GWK37_RS10470	COG2271	Major facilitator Superfamily
GWK37_RS10480	COG2368	4-hydroxyphenylacetate
GWK37_RS10490	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS10505	COG0371	Dehydrogenase
GWK37_RS10515	COG1183	phosphatidylcholine synthase activity
GWK37_RS10520	COG0586	Pfam SNARE associated Golgi protein
GWK37_RS10525	COG0688	phosphatidylethanolamine metabolic process
GWK37_RS10540	COG1301	dicarboxylic acid transport
GWK37_RS10545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS10550	COG0833	amino acid
GWK37_RS10555	COG2040	homocysteine
GWK37_RS10560	COG1115	amino acid carrier protein
GWK37_RS10565	COG2066	Belongs to the glutaminase family
GWK37_RS10570	COG4191	Histidine kinase
GWK37_RS10575	COG0784	Response regulator, receiver
GWK37_RS10580	COG3173	Aminoglycoside phosphotransferase
GWK37_RS10595	COG3773	Cell wall hydrolase
GWK37_RS10600	COG3540	Alkaline phosphatase
GWK37_RS10605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK37_RS10610	COG0805	protein transport
GWK37_RS10620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK37_RS10625	COG0477	Major facilitator Superfamily
GWK37_RS10630	COG1309	transcriptional regulator
GWK37_RS10635	COG0252	asparaginase activity
GWK37_RS10640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWK37_RS10645	COG3012	SEC-C Motif Domain Protein
GWK37_RS10645	COG1405	negative regulation of cell septum assembly
GWK37_RS10650	COG0667	Aldo Keto reductase
GWK37_RS10660	COG1595	DNA-templated transcription, initiation
GWK37_RS10665	COG1595	DNA-templated transcription, initiation
GWK37_RS10670	COG1876	peptidase activity
GWK37_RS10675	COG0457	Tetratricopeptide repeat
GWK37_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS10690	COG0366	Alpha amylase catalytic
GWK37_RS10695	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWK37_RS10700	COG1121	(ABC) transporter
GWK37_RS10705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK37_RS10710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK37_RS10715	COG2310	stress, protein
GWK37_RS10720	COG2310	stress, protein
GWK37_RS10725	COG2310	stress, protein
GWK37_RS10730	COG0861	Integral membrane protein TerC family
GWK37_RS10740	COG3853	Toxic anion resistance protein (TelA)
GWK37_RS10745	COG0477	Major facilitator Superfamily
GWK37_RS10750	COG4175	Glycine betaine
GWK37_RS10750	COG0517	IMP dehydrogenase activity
GWK37_RS10755	COG4176	ABC-type proline glycine betaine transport system permease component
GWK37_RS10760	COG2113	Glycine betaine
GWK37_RS10765	COG1473	amidohydrolase
GWK37_RS10770	COG1288	antiporter activity
GWK37_RS10790	COG2814	Major facilitator Superfamily
GWK37_RS10795	COG1846	Transcriptional regulator
GWK37_RS10800	COG1280	lysine exporter protein (LysE YggA)
GWK37_RS10805	COG3403	YqcI/YcgG family
GWK37_RS10810	COG1113	amino acid transport
GWK37_RS10815	COG3665	Urea carboxylase-associated protein
GWK37_RS10830	COG1660	Displays ATPase and GTPase activities
GWK37_RS10840	COG2271	Major facilitator Superfamily
GWK37_RS10845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWK37_RS10850	COG3458	cephalosporin-C deacetylase activity
GWK37_RS10855	COG3541	Predicted nucleotidyltransferase
GWK37_RS10860	COG0506	proline dehydrogenase activity
GWK37_RS10865	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS10870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK37_RS10875	COG2508	Transcriptional regulator
GWK37_RS10885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK37_RS10885	COG1587	Uroporphyrinogen-III synthase
GWK37_RS10890	COG2146	nitrite reductase [NAD(P)H] activity
GWK37_RS10895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK37_RS10900	COG0243	molybdopterin cofactor binding
GWK37_RS10905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK37_RS10910	COG2223	nitrite transmembrane transporter activity
GWK37_RS10915	COG0523	cobalamin synthesis protein
GWK37_RS10920	COG1063	alcohol dehydrogenase
GWK37_RS10925	COG1714	RDD family
GWK37_RS10935	COG2723	6-phospho-beta-galactosidase activity
GWK37_RS10945	COG3209	COG3209 Rhs family protein
GWK37_RS10950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWK37_RS10955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GWK37_RS10960	COG1733	regulation of RNA biosynthetic process
GWK37_RS10965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS10970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS10975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS10980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GWK37_RS10995	COG2364	Membrane
GWK37_RS11000	COG1126	abc transporter atp-binding protein
GWK37_RS11005	COG0765	amino acid transport
GWK37_RS11010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS11015	COG0583	DNA-binding transcription factor activity
GWK37_RS11020	COG0163	prenyltransferase activity
GWK37_RS11025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWK37_RS11040	COG3104	oligopeptide transport
GWK37_RS11045	COG5434	Belongs to the glycosyl hydrolase 28 family
GWK37_RS11055	COG0697	spore germination
GWK37_RS11065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK37_RS11080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK37_RS11085	COG0765	amino acid transport
GWK37_RS11090	COG1126	abc transporter atp-binding protein
GWK37_RS11100	COG2079	MmgE PrpD family protein
GWK37_RS11105	COG1136	(ABC) transporter
GWK37_RS11110	COG0577	efflux transmembrane transporter activity
GWK37_RS11115	COG0745	RESPONSE REGULATOR receiver
GWK37_RS11120	COG3850	Histidine kinase
GWK37_RS11120	COG5002	protein histidine kinase activity
GWK37_RS11125	COG0457	Tetratricopeptide repeat
GWK37_RS11140	COG0527	aspartate kinase activity
GWK37_RS11145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK37_RS11150	COG4605	iron ion homeostasis
GWK37_RS11155	COG4604	ABC transporter, ATP-binding protein
GWK37_RS11160	COG4607	ABC-type enterochelin transport system periplasmic component
GWK37_RS11165	COG2814	Major facilitator Superfamily
GWK37_RS11170	COG1309	transcriptional regulator
GWK37_RS11175	COG0778	Nitroreductase
GWK37_RS11180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GWK37_RS11185	COG0640	Transcriptional regulator
GWK37_RS11190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS11195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS11205	COG4975	Glucose uptake
GWK37_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS11215	COG4549	nuclear export factor GLE1
GWK37_RS11220	COG2372	response to copper ion
GWK37_RS11220	COG1276	copper resistance
GWK37_RS11225	COG1349	DNA-binding transcription factor activity
GWK37_RS11235	COG2213	PTS system mannitol-specific
GWK37_RS11240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS11250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWK37_RS11260	COG0561	phosphatase activity
GWK37_RS11270	COG1914	H( )-stimulated, divalent metal cation uptake system
GWK37_RS11280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GWK37_RS11285	COG1984	allophanate hydrolase subunit 2
GWK37_RS11290	COG1414	Transcriptional regulator
GWK37_RS11295	COG2755	lipolytic protein G-D-S-L family
GWK37_RS11305	COG2329	Antibiotic biosynthesis monooxygenase
GWK37_RS11310	COG0768	penicillin binding
GWK37_RS11315	COG4989	oxidoreductase activity
GWK37_RS11320	COG3711	transcriptional antiterminator
GWK37_RS11325	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS11335	COG1917	Cupin 2, conserved barrel domain protein
GWK37_RS11340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS11345	COG3871	stress protein (general stress protein 26)
GWK37_RS11355	COG2814	Major facilitator Superfamily
GWK37_RS11360	COG1522	sequence-specific DNA binding
GWK37_RS11365	COG0551	DNA topoisomerase type I activity
GWK37_RS11365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK37_RS11370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GWK37_RS11375	COG3706	GGDEF domain
GWK37_RS11380	COG5298	Protein conserved in bacteria
GWK37_RS11385	COG1215	transferase activity, transferring glycosyl groups
GWK37_RS11395	COG0531	amino acid
GWK37_RS11400	COG0494	nUDIX hydrolase
GWK37_RS11405	COG0028	Belongs to the TPP enzyme family
GWK37_RS11430	COG1914	H( )-stimulated, divalent metal cation uptake system
GWK37_RS11440	COG4876	unkown
GWK37_RS11450	COG2076	Multidrug Resistance protein
GWK37_RS11455	COG2217	Heavy metal translocating P-type atpase
GWK37_RS11460	COG3729	General stress protein
GWK37_RS11465	COG0662	Cupin 2, conserved barrel domain protein
GWK37_RS11470	COG2329	Antibiotic biosynthesis monooxygenase
GWK37_RS11475	COG3546	catalase activity
GWK37_RS11480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GWK37_RS11485	COG3290	protein histidine kinase activity
GWK37_RS11490	COG4565	transcriptional regulatory protein
GWK37_RS11495	COG1301	dicarboxylic acid transport
GWK37_RS11500	COG0628	permease
GWK37_RS11505	COG1131	(ABC) transporter
GWK37_RS11510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWK37_RS11520	COG1960	acyl-CoA dehydrogenase activity
GWK37_RS11535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWK37_RS11540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS11550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWK37_RS11555	COG0513	Belongs to the DEAD box helicase family
GWK37_RS11560	COG3402	PFAM membrane-flanked domain
GWK37_RS11565	COG3428	Bacterial PH domain
GWK37_RS11570	COG0705	Rhomboid family
GWK37_RS11580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWK37_RS11585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWK37_RS11590	COG0864	Transcriptional regulator
GWK37_RS11595	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWK37_RS11600	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS11605	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS11610	COG2172	sigma factor antagonist activity
GWK37_RS11615	COG2208	phosphoserine phosphatase activity
GWK37_RS11620	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS11630	COG1191	sigma factor activity
GWK37_RS11635	COG2208	phosphoserine phosphatase activity
GWK37_RS11640	COG2183	response to ionizing radiation
GWK37_RS11695	COG5444	nuclease activity
GWK37_RS11700	COG0457	Tetratricopeptide repeat
GWK37_RS11705	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK37_RS11725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK37_RS11730	COG0477	Major facilitator Superfamily
GWK37_RS11750	COG2030	dehydratase
GWK37_RS11765	COG1959	2 iron, 2 sulfur cluster binding
GWK37_RS11770	COG2910	NAD(P)H-binding
GWK37_RS11780	COG1278	Cold shock
GWK37_RS11785	COG1329	Transcriptional regulator
GWK37_RS11790	COG1937	Protein conserved in bacteria
GWK37_RS11795	COG2210	Belongs to the sulfur carrier protein TusA family
GWK37_RS11805	COG0425	Belongs to the sulfur carrier protein TusA family
GWK37_RS11805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK37_RS11810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK37_RS11810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS11815	COG0425	Belongs to the sulfur carrier protein TusA family
GWK37_RS11820	COG0730	response to heat
GWK37_RS11825	COG1794	racemase activity, acting on amino acids and derivatives
GWK37_RS11840	COG3621	Patatin-like phospholipase
GWK37_RS11850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK37_RS11860	COG0251	oxidation-reduction process
GWK37_RS11865	COG0814	amino acid
GWK37_RS11870	COG1473	amidohydrolase
GWK37_RS11875	COG1917	Cupin 2, conserved barrel domain protein
GWK37_RS11875	COG2207	Transcriptional regulator
GWK37_RS11885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS11890	COG0477	Major facilitator Superfamily
GWK37_RS11910	COG0277	FAD linked oxidase domain protein
GWK37_RS11935	COG0662	Cupin 2, conserved barrel domain protein
GWK37_RS11940	COG2318	DinB family
GWK37_RS11945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK37_RS11970	COG0351	phosphomethylpyrimidine kinase
GWK37_RS11985	COG1064	alcohol dehydrogenase
GWK37_RS11990	COG0789	Transcriptional regulator
GWK37_RS12000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS12015	COG2814	Major facilitator Superfamily
GWK37_RS12020	COG1309	transcriptional regulator
GWK37_RS12025	COG0697	spore germination
GWK37_RS12030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS12035	COG5577	PFAM Coat F domain
GWK37_RS12045	COG1063	alcohol dehydrogenase
GWK37_RS12050	COG5577	PFAM Coat F domain
GWK37_RS12060	COG4585	Histidine kinase
GWK37_RS12065	COG2197	response regulator
GWK37_RS12070	COG2409	Drug exporters of the RND superfamily
GWK37_RS12075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWK37_RS12085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS12090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS12100	COG2814	Major facilitator Superfamily
GWK37_RS12105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWK37_RS12115	COG0730	response to heat
GWK37_RS12120	COG0456	acetyltransferase
GWK37_RS12125	COG0789	Transcriptional regulator
GWK37_RS12125	COG4978	Transcriptional regulator
GWK37_RS12130	COG0697	spore germination
GWK37_RS12135	COG1051	belongs to the nudix hydrolase family
GWK37_RS12140	COG2226	methyltransferase
GWK37_RS12145	COG0473	3-isopropylmalate dehydrogenase activity
GWK37_RS12150	COG1802	Transcriptional regulator
GWK37_RS12155	COG1819	glycosyl
GWK37_RS12170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK37_RS12175	COG1388	LysM domain
GWK37_RS12180	COG2814	Major facilitator Superfamily
GWK37_RS12185	COG2188	Transcriptional regulator
GWK37_RS12190	COG2186	Transcriptional regulator
GWK37_RS12195	COG2807	transmembrane transport
GWK37_RS12200	COG2076	Multidrug Resistance protein
GWK37_RS12205	COG2076	Multidrug Resistance protein
GWK37_RS12210	COG1309	transcriptional regulator
GWK37_RS12215	COG0531	amino acid
GWK37_RS12225	COG3832	glyoxalase III activity
GWK37_RS12230	COG0604	alcohol dehydrogenase
GWK37_RS12235	COG2814	Major facilitator Superfamily
GWK37_RS12275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWK37_RS12280	COG0802	atpase or kinase
GWK37_RS12285	COG1214	PFAM Peptidase M22, glycoprotease
GWK37_RS12290	COG0456	acetyltransferase
GWK37_RS12295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWK37_RS12300	COG0488	(ABC) transporter
GWK37_RS12315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK37_RS12320	COG0805	protein transport
GWK37_RS12330	COG1266	CAAX protease self-immunity
GWK37_RS12335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWK37_RS12345	COG0156	8-amino-7-oxononanoate synthase activity
GWK37_RS12365	COG3403	YqcI/YcgG family
GWK37_RS12380	COG2814	Major facilitator Superfamily
GWK37_RS12385	COG0457	Tetratricopeptide repeat
GWK37_RS12390	COG1063	alcohol dehydrogenase
GWK37_RS12395	COG2211	Major facilitator Superfamily
GWK37_RS12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK37_RS12410	COG1842	Phage shock protein A
GWK37_RS12415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK37_RS12420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWK37_RS12425	COG4260	virion core protein, lumpy skin disease virus
GWK37_RS12430	COG2755	lipolytic protein G-D-S-L family
GWK37_RS12430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWK37_RS12440	COG1595	DNA-templated transcription, initiation
GWK37_RS12445	COG1063	alcohol dehydrogenase
GWK37_RS12450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWK37_RS12455	COG0823	Involved in the tonB-independent uptake of proteins
GWK37_RS12465	COG2132	Multicopper oxidase
GWK37_RS12470	COG1113	amino acid transport
GWK37_RS12475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWK37_RS12480	COG0714	Associated with various cellular activities
GWK37_RS12485	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GWK37_RS12490	COG1305	Transglutaminase-like
GWK37_RS12500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK37_RS12520	COG2211	Major facilitator Superfamily
GWK37_RS12535	COG2252	PERMEase
GWK37_RS12540	COG3064	Membrane
GWK37_RS12560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWK37_RS12565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWK37_RS12570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK37_RS12575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWK37_RS12580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWK37_RS12595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWK37_RS12605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWK37_RS12610	COG0138	bifunctional purine biosynthesis protein purh
GWK37_RS12615	COG0151	Belongs to the GarS family
GWK37_RS12625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWK37_RS12630	COG1470	cell adhesion involved in biofilm formation
GWK37_RS12635	COG4496	protein, YerC YecD
GWK37_RS12640	COG0069	glutamate synthase activity
GWK37_RS12650	COG0210	DNA helicase
GWK37_RS12660	COG4851	CamS sex pheromone cAM373 precursor
GWK37_RS12665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK37_RS12670	COG1285	pathogenesis
GWK37_RS12675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK37_RS12695	COG1309	transcriptional regulator
GWK37_RS12700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK37_RS12705	COG1597	lipid kinase activity
GWK37_RS12710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWK37_RS12715	COG1136	(ABC) transporter
GWK37_RS12725	COG1131	(ABC) transporter
GWK37_RS12755	COG5444	nuclease activity
GWK37_RS12765	COG5444	nuclease activity
GWK37_RS12795	COG3546	catalase activity
GWK37_RS12800	COG0454	-acetyltransferase
GWK37_RS12810	COG2323	membrane
GWK37_RS12815	COG2329	Antibiotic biosynthesis monooxygenase
GWK37_RS12820	COG0346	lactoylglutathione lyase activity
GWK37_RS12825	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS12830	COG5583	Uncharacterized small protein (DUF2292)
GWK37_RS12835	COG0196	riboflavin kinase activity
GWK37_RS12840	COG0670	Belongs to the BI1 family
GWK37_RS12845	COG1846	Transcriptional regulator
GWK37_RS12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK37_RS12860	COG2124	cytochrome p450
GWK37_RS12860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWK37_RS12865	COG1368	sulfuric ester hydrolase activity
GWK37_RS12870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK37_RS12875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS12880	COG1442	glycosyl transferase family 8
GWK37_RS12885	COG1216	Glycosyl transferase, family 2
GWK37_RS12890	COG1442	glycosyl transferase family 8
GWK37_RS12895	COG2223	nitrite transmembrane transporter activity
GWK37_RS12900	COG0531	amino acid
GWK37_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS12910	COG0840	transmembrane signaling receptor activity
GWK37_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS12920	COG0457	Tetratricopeptide repeat
GWK37_RS12920	COG0463	Glycosyl transferase, family 2
GWK37_RS12925	COG0488	(ABC) transporter
GWK37_RS12930	COG0789	Transcriptional regulator
GWK37_RS12935	COG2814	Major facilitator Superfamily
GWK37_RS12940	COG0488	(ABC) transporter
GWK37_RS12945	COG0513	Belongs to the DEAD box helicase family
GWK37_RS12950	COG0456	acetyltransferase
GWK37_RS12955	COG2130	NADP-dependent
GWK37_RS12970	COG3866	Pectate lyase
GWK37_RS12975	COG0471	metal ion transport
GWK37_RS12995	COG2972	Histidine kinase
GWK37_RS12995	COG0745	RESPONSE REGULATOR receiver
GWK37_RS13000	COG3279	Response regulator of the LytR AlgR family
GWK37_RS13010	COG3764	Sortase (surface protein transpeptidase)
GWK37_RS13015	COG3290	protein histidine kinase activity
GWK37_RS13020	COG4565	transcriptional regulatory protein
GWK37_RS13025	COG3181	Tripartite tricarboxylate transporter family receptor
GWK37_RS13030	COG2851	Citrate transporter
GWK37_RS13035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS13040	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GWK37_RS13050	COG2258	MOSC domain
GWK37_RS13070	COG0024	Methionine aminopeptidase
GWK37_RS13075	COG1263	PTS System
GWK37_RS13075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS13085	COG1368	sulfuric ester hydrolase activity
GWK37_RS13095	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK37_RS13110	COG1263	PTS System
GWK37_RS13110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS13115	COG0366	Alpha amylase catalytic
GWK37_RS13120	COG2188	Transcriptional regulator
GWK37_RS13125	COG0778	Nitroreductase
GWK37_RS13140	COG0737	Belongs to the 5'-nucleotidase family
GWK37_RS13145	COG0693	protein deglycase activity
GWK37_RS13150	COG1609	Transcriptional regulator
GWK37_RS13155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK37_RS13165	COG2814	Major facilitator Superfamily
GWK37_RS13175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK37_RS13180	COG4980	gas vesicle protein
GWK37_RS13185	COG1295	ribonuclease BN
GWK37_RS13190	COG0477	Major facilitator Superfamily
GWK37_RS13195	COG0387	Pfam Sodium calcium exchanger
GWK37_RS13205	COG0668	transmembrane transport
GWK37_RS13210	COG0535	radical SAM domain protein
GWK37_RS13220	COG0726	polysaccharide deacetylase
GWK37_RS13225	COG2084	Dehydrogenase
GWK37_RS13235	COG0598	Magnesium transport protein CorA
GWK37_RS13240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GWK37_RS13245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWK37_RS13260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK37_RS13265	COG4637	Psort location Cytoplasmic, score
GWK37_RS13270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK37_RS13275	COG0022	dehydrogenase e1 component
GWK37_RS13280	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK37_RS13285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK37_RS13290	COG3284	Transcriptional regulator
GWK37_RS13300	COG1486	melibiose metabolic process
GWK37_RS13305	COG1737	Transcriptional regulator
GWK37_RS13310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS13310	COG1263	PTS System
GWK37_RS13315	COG1132	(ABC) transporter
GWK37_RS13320	COG1132	(ABC) transporter
GWK37_RS13325	COG2259	Doxx family
GWK37_RS13330	COG2514	catechol 2,3-dioxygenase activity
GWK37_RS13340	COG1695	Transcriptional regulator
GWK37_RS13345	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK37_RS13350	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GWK37_RS13355	COG3848	Pyruvate phosphate dikinase
GWK37_RS13355	COG0574	Belongs to the PEP-utilizing enzyme family
GWK37_RS13360	COG2732	(Barnase) inhibitor
GWK37_RS13370	COG2814	Major facilitator Superfamily
GWK37_RS13375	COG1846	Transcriptional regulator
GWK37_RS13380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWK37_RS13380	COG0392	lysyltransferase activity
GWK37_RS13385	COG0384	phenazine biosynthesis protein PhzF
GWK37_RS13390	COG0778	Nitroreductase
GWK37_RS13405	COG1090	epimerase
GWK37_RS13420	COG2814	Major facilitator Superfamily
GWK37_RS13430	COG3591	Belongs to the peptidase S1B family
GWK37_RS13445	COG3103	Sh3 type 3 domain protein
GWK37_RS13450	COG5658	integral membrane protein
GWK37_RS13455	COG0596	Alpha beta hydrolase
GWK37_RS13460	COG0463	Glycosyl transferase, family 2
GWK37_RS13465	COG4485	Bacterial membrane protein, YfhO
GWK37_RS13470	COG1988	membrane-bound metal-dependent
GWK37_RS13475	COG1194	a g-specific adenine glycosylase
GWK37_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS13505	COG1132	(ABC) transporter
GWK37_RS13510	COG4129	membrane
GWK37_RS13520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK37_RS13525	COG0735	belongs to the Fur family
GWK37_RS13640	COG3340	Belongs to the peptidase S51 family
GWK37_RS13650	COG0277	FAD linked oxidase domain protein
GWK37_RS13660	COG0747	negative chemotaxis
GWK37_RS13665	COG0601	transmembrane transport
GWK37_RS13670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK37_RS13675	COG0444	Belongs to the ABC transporter superfamily
GWK37_RS13680	COG4608	Belongs to the ABC transporter superfamily
GWK37_RS13685	COG0753	catalase activity
GWK37_RS13695	COG1116	anion transmembrane transporter activity
GWK37_RS13700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK37_RS13705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK37_RS13725	COG1476	TRANSCRIPTIONal
GWK37_RS13735	COG3382	B3 4 domain protein
GWK37_RS13740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWK37_RS13750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWK37_RS13755	COG0789	Transcriptional regulator
GWK37_RS13760	COG1664	Polymer-forming cytoskeletal
GWK37_RS13765	COG1664	Polymer-forming cytoskeletal
GWK37_RS13770	COG2766	serine protein kinase
GWK37_RS13780	COG1846	Transcriptional regulator
GWK37_RS13785	COG1566	PFAM secretion protein HlyD family protein
GWK37_RS13790	COG2814	Major facilitator Superfamily
GWK37_RS13795	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK37_RS13810	COG1725	Transcriptional regulator
GWK37_RS13815	COG1131	(ABC) transporter
GWK37_RS13820	COG1131	(ABC) transporter
GWK37_RS13825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWK37_RS13830	COG1278	Cold shock
GWK37_RS13835	COG1464	Belongs to the NlpA lipoprotein family
GWK37_RS13840	COG3706	GGDEF domain
GWK37_RS13845	COG1823	symporter activity
GWK37_RS13865	COG5577	PFAM Coat F domain
GWK37_RS13870	COG0737	Belongs to the 5'-nucleotidase family
GWK37_RS13870	COG1525	nuclease
GWK37_RS13870	COG4085	toxin activity
GWK37_RS13875	COG3764	Sortase (surface protein transpeptidase)
GWK37_RS13880	COG0564	pseudouridine synthase activity
GWK37_RS13890	COG0517	IMP dehydrogenase activity
GWK37_RS13895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK37_RS13900	COG3153	acetyltransferase
GWK37_RS13900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK37_RS13905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWK37_RS13910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GWK37_RS13915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWK37_RS13925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWK37_RS13930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK37_RS13935	COG4585	Histidine kinase
GWK37_RS13935	COG2203	Gaf domain
GWK37_RS13940	COG2197	response regulator
GWK37_RS13945	COG0431	NADPH-dependent FMN reductase
GWK37_RS13960	COG0791	NLP P60 protein
GWK37_RS13960	COG1388	LysM domain
GWK37_RS13965	COG1959	2 iron, 2 sulfur cluster binding
GWK37_RS13970	COG0668	transmembrane transport
GWK37_RS13975	COG2719	SpoVR family
GWK37_RS13980	COG1785	Belongs to the alkaline phosphatase family
GWK37_RS13985	COG1388	LysM domain
GWK37_RS13985	COG0791	NLP P60 protein
GWK37_RS13990	COG0583	DNA-binding transcription factor activity
GWK37_RS13995	COG0372	Belongs to the citrate synthase family
GWK37_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS14005	COG0531	amino acid
GWK37_RS14010	COG0733	neurotransmitter:sodium symporter activity
GWK37_RS14025	COG1595	DNA-templated transcription, initiation
GWK37_RS14030	COG0204	Acyl-transferase
GWK37_RS14035	COG1253	flavin adenine dinucleotide binding
GWK37_RS14040	COG0789	Transcriptional regulator
GWK37_RS14045	COG0436	Aminotransferase
GWK37_RS14050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWK37_RS14055	COG1253	flavin adenine dinucleotide binding
GWK37_RS14060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK37_RS14065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK37_RS14070	COG0584	glycerophosphoryl diester phosphodiesterase
GWK37_RS14080	COG0668	transmembrane transport
GWK37_RS14085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWK37_RS14090	COG0726	polysaccharide deacetylase
GWK37_RS14095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK37_RS14100	COG3226	Transcriptional regulator
GWK37_RS14110	COG0589	response to stress
GWK37_RS14115	COG1132	(ABC) transporter
GWK37_RS14120	COG1132	(ABC) transporter
GWK37_RS14125	COG0702	epimerase
GWK37_RS14140	COG0189	ligase activity
GWK37_RS14145	COG0189	ligase activity
GWK37_RS14160	COG4335	DNA alkylation repair
GWK37_RS14165	COG0561	phosphatase activity
GWK37_RS14170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK37_RS14180	COG0475	glutathione-regulated potassium exporter activity
GWK37_RS14185	COG0490	domain, Protein
GWK37_RS14195	COG1024	Enoyl-CoA hydratase
GWK37_RS14205	COG4152	abc transporter atp-binding protein
GWK37_RS14210	COG1668	transmembrane transport
GWK37_RS14215	COG0420	3'-5' exonuclease activity
GWK37_RS14220	COG4717	serine-type aminopeptidase activity
GWK37_RS14235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK37_RS14270	COG4980	gas vesicle protein
GWK37_RS14285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWK37_RS14290	COG0537	adenosine 5'-monophosphoramidase activity
GWK37_RS14295	COG1131	(ABC) transporter
GWK37_RS14300	COG4473	ABC transporter
GWK37_RS14310	COG1473	amidohydrolase
GWK37_RS14315	COG3069	C4-dicarboxylate transmembrane transporter activity
GWK37_RS14320	COG2329	Antibiotic biosynthesis monooxygenase
GWK37_RS14325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK37_RS14345	COG1309	transcriptional regulator
GWK37_RS14350	COG1511	domain protein
GWK37_RS14355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK37_RS14365	COG1363	Peptidase, m42
GWK37_RS14370	COG1301	dicarboxylic acid transport
GWK37_RS14380	COG1234	tRNA 3'-trailer cleavage
GWK37_RS14385	COG0095	Lipoate-protein ligase
GWK37_RS14390	COG0702	epimerase
GWK37_RS14395	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS14405	COG0501	Belongs to the peptidase M48B family
GWK37_RS14410	COG1404	Belongs to the peptidase S8 family
GWK37_RS14420	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWK37_RS14425	COG0406	alpha-ribazole phosphatase activity
GWK37_RS14430	COG0183	Belongs to the thiolase family
GWK37_RS14435	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS14440	COG1268	BioY protein
GWK37_RS14445	COG0840	transmembrane signaling receptor activity
GWK37_RS14450	COG0723	plastoquinol--plastocyanin reductase activity
GWK37_RS14450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK37_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS14465	COG4903	ComK protein
GWK37_RS14475	COG5646	InterPro IPR014922
GWK37_RS14500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK37_RS14515	COG0398	Pfam SNARE associated Golgi protein
GWK37_RS14520	COG0681	Belongs to the peptidase S26 family
GWK37_RS14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK37_RS14530	COG1846	Transcriptional regulator
GWK37_RS14535	COG3180	Ammonia monooxygenase
GWK37_RS14540	COG2814	Major facilitator Superfamily
GWK37_RS14550	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GWK37_RS14555	COG2323	membrane
GWK37_RS14570	COG0420	3'-5' exonuclease activity
GWK37_RS14575	COG0419	ATPase involved in DNA repair
GWK37_RS14580	COG1403	HNH endonuclease
GWK37_RS14620	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK37_RS14635	COG0367	asparagine synthase
GWK37_RS14640	COG1562	ergosterol biosynthetic process
GWK37_RS14645	COG0534	Mate efflux family protein
GWK37_RS14650	COG1917	Cupin 2, conserved barrel domain protein
GWK37_RS14650	COG2207	Transcriptional regulator
GWK37_RS14655	COG1609	Transcriptional regulator
GWK37_RS14660	COG0673	inositol 2-dehydrogenase activity
GWK37_RS14665	COG2318	DinB family
GWK37_RS14670	COG1279	arginine transmembrane transporter activity
GWK37_RS14675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK37_RS14680	COG1357	PFAM Pentapeptide repeats (8 copies)
GWK37_RS14685	COG2153	protein acetylation
GWK37_RS14690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GWK37_RS14690	COG0646	methionine synthase
GWK37_RS14700	COG2996	Protein conserved in bacteria
GWK37_RS14710	COG0840	transmembrane signaling receptor activity
GWK37_RS14715	COG2124	cytochrome p450
GWK37_RS14725	COG1307	EDD domain protein, DegV family
GWK37_RS14730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWK37_RS14755	COG0561	phosphatase activity
GWK37_RS14760	COG1073	alpha beta
GWK37_RS14765	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK37_RS14775	COG0277	FAD linked oxidase domain protein
GWK37_RS14780	COG2271	Major facilitator Superfamily
GWK37_RS14800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK37_RS14805	COG0505	Belongs to the CarA family
GWK37_RS14810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK37_RS14815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWK37_RS14830	COG2267	carboxylic ester hydrolase activity
GWK37_RS14840	COG1744	ABC transporter substrate-binding protein PnrA-like
GWK37_RS14855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWK37_RS14860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWK37_RS14865	COG5504	Zn-dependent protease
GWK37_RS14870	COG0444	Belongs to the ABC transporter superfamily
GWK37_RS14875	COG4608	Belongs to the ABC transporter superfamily
GWK37_RS14885	COG0601	transmembrane transport
GWK37_RS14890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK37_RS14900	COG0180	Tryptophanyl-tRNA synthetase
GWK37_RS14905	COG4166	transmembrane transport
GWK37_RS14910	COG0601	transmembrane transport
GWK37_RS14915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK37_RS14920	COG0444	Belongs to the ABC transporter superfamily
GWK37_RS14925	COG4608	Belongs to the ABC transporter superfamily
GWK37_RS14935	COG0456	acetyltransferase
GWK37_RS14940	COG1393	Belongs to the ArsC family
GWK37_RS14945	COG0861	Integral membrane protein TerC family
GWK37_RS14950	COG4862	establishment of competence for transformation
GWK37_RS14955	COG4469	Competence protein
GWK37_RS14960	COG1164	Oligoendopeptidase f
GWK37_RS14970	COG2346	COG2346, Truncated hemoglobins
GWK37_RS14975	COG0741	lytic transglycosylase activity
GWK37_RS14980	COG4116	CYTH
GWK37_RS14990	COG2357	RelA SpoT domain protein
GWK37_RS14995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK37_RS15000	COG0564	pseudouridine synthase activity
GWK37_RS15010	COG0475	glutathione-regulated potassium exporter activity
GWK37_RS15010	COG0569	domain protein
GWK37_RS15015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK37_RS15020	COG0352	thiamine-phosphate diphosphorylase activity
GWK37_RS15025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK37_RS15030	COG2104	thiamine diphosphate biosynthetic process
GWK37_RS15040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK37_RS15045	COG0351	phosphomethylpyrimidine kinase
GWK37_RS15050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWK37_RS15105	COG0210	DNA helicase
GWK37_RS15125	COG1131	(ABC) transporter
GWK37_RS15135	COG2153	protein acetylation
GWK37_RS15145	COG2382	esterase
GWK37_RS15150	COG0626	cystathionine gamma-synthase activity
GWK37_RS15155	COG0626	cystathionine gamma-synthase activity
GWK37_RS15175	COG0582	viral genome integration into host DNA
GWK37_RS15310	COG5444	nuclease activity
GWK37_RS15350	COG0135	phosphoribosylanthranilate isomerase activity
GWK37_RS15360	COG0346	lactoylglutathione lyase activity
GWK37_RS15365	COG2367	Beta-lactamase
GWK37_RS15370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GWK37_RS15380	COG1846	Transcriptional regulator
GWK37_RS15390	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GWK37_RS15395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK37_RS15400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWK37_RS15405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS15405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWK37_RS15410	COG1447	Phosphotransferase system cellobiose-specific component IIA
GWK37_RS15440	COG1285	pathogenesis
GWK37_RS15455	COG2205	protein histidine kinase activity
GWK37_RS15465	COG3383	formate dehydrogenase (NAD+) activity
GWK37_RS15470	COG2427	Protein of unknown function (DUF1641)
GWK37_RS15475	COG2124	cytochrome p450
GWK37_RS15480	COG1819	glycosyl
GWK37_RS15490	COG1587	Uroporphyrinogen-III synthase
GWK37_RS15495	COG0390	transport system, permease component
GWK37_RS15500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK37_RS15505	COG0697	spore germination
GWK37_RS15510	COG4297	protein containing double-stranded beta helix domain
GWK37_RS15520	COG1252	NADH dehydrogenase
GWK37_RS15530	COG2211	Major facilitator Superfamily
GWK37_RS15535	COG1609	Transcriptional regulator
GWK37_RS15540	COG0246	Mannitol dehydrogenase
GWK37_RS15545	COG2721	sulfolactate sulfo-lyase activity
GWK37_RS15550	COG0745	RESPONSE REGULATOR receiver
GWK37_RS15555	COG2770	Histidine kinase
GWK37_RS15555	COG2205	protein histidine kinase activity
GWK37_RS15575	COG4585	Histidine kinase
GWK37_RS15580	COG2197	response regulator
GWK37_RS15605	COG0730	response to heat
GWK37_RS15610	COG2318	DinB family
GWK37_RS15615	COG0457	Tetratricopeptide repeat
GWK37_RS15625	COG1388	LysM domain
GWK37_RS15625	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS15625	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS15635	COG4195	phage-related replication protein
GWK37_RS15640	COG3546	catalase activity
GWK37_RS15645	COG2856	Zn peptidase
GWK37_RS15650	COG1396	sequence-specific DNA binding
GWK37_RS15660	COG1522	sequence-specific DNA binding
GWK37_RS15665	COG1484	DNA-dependent DNA replication
GWK37_RS15680	COG1595	DNA-templated transcription, initiation
GWK37_RS15685	COG5484	DNA packaging
GWK37_RS15685	COG3728	DNA packaging
GWK37_RS15690	COG1783	phage Terminase large subunit
GWK37_RS15695	COG5518	Phage portal protein
GWK37_RS15700	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWK37_RS15705	COG4653	Phage capsid family
GWK37_RS15755	COG3953	SLT domain
GWK37_RS15755	COG3953	SLT domain
GWK37_RS15755	COG5412	phage tail tape measure protein
GWK37_RS15755	COG3953	SLT domain
GWK37_RS15755	COG5412	phage tail tape measure protein
GWK37_RS15755	COG5412	phage tail tape measure protein
GWK37_RS15760	COG1652	LysM domain
GWK37_RS15765	COG4193	domain, Protein
GWK37_RS15775	COG3628	GPW Gp25 family protein
GWK37_RS15780	COG3299	homolog of phage Mu protein gp47
GWK37_RS15785	COG3778	Protein conserved in bacteria
GWK37_RS15825	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS15825	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS15840	COG0306	phosphate transporter
GWK37_RS15845	COG1392	Phosphate transport regulator
GWK37_RS15850	COG0531	amino acid
GWK37_RS15855	COG0346	lactoylglutathione lyase activity
GWK37_RS15860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWK37_RS15865	COG0463	Glycosyl transferase, family 2
GWK37_RS15870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK37_RS15875	COG0477	Major facilitator Superfamily
GWK37_RS15880	COG2362	D-Aminopeptidase
GWK37_RS15885	COG0601	transmembrane transport
GWK37_RS15890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK37_RS15895	COG0444	Belongs to the ABC transporter superfamily
GWK37_RS15900	COG4166	transmembrane transport
GWK37_RS15905	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWK37_RS15910	COG4948	Mandelate Racemase Muconate Lactonizing
GWK37_RS15915	COG0791	NLP P60 protein
GWK37_RS15920	COG4608	Belongs to the ABC transporter superfamily
GWK37_RS15925	COG2706	6-phosphogluconolactonase activity
GWK37_RS15930	COG1834	amidinotransferase
GWK37_RS15935	COG1607	acyl-coa hydrolase
GWK37_RS15940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS15945	COG2076	Multidrug Resistance protein
GWK37_RS15950	COG2076	Multidrug Resistance protein
GWK37_RS15955	COG0788	formyltetrahydrofolate deformylase activity
GWK37_RS15960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GWK37_RS15970	COG1764	response to oxidative stress
GWK37_RS15975	COG1846	Transcriptional regulator
GWK37_RS15980	COG1764	response to oxidative stress
GWK37_RS15995	COG0457	Tetratricopeptide repeat
GWK37_RS15995	COG0463	Glycosyl transferase, family 2
GWK37_RS16005	COG2814	Major facilitator Superfamily
GWK37_RS16010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK37_RS16020	COG1404	Belongs to the peptidase S8 family
GWK37_RS16025	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS16030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GWK37_RS16035	COG1122	ATPase activity
GWK37_RS16040	COG4721	ABC-type cobalt transport system, permease component
GWK37_RS16045	COG1388	LysM domain
GWK37_RS16045	COG3858	chitin binding
GWK37_RS16060	COG2239	Acts as a magnesium transporter
GWK37_RS16065	COG0789	Transcriptional regulator
GWK37_RS16080	COG1846	Transcriptional regulator
GWK37_RS16085	COG0726	polysaccharide deacetylase
GWK37_RS16090	COG3285	dna ligase
GWK37_RS16090	COG1793	dna ligase
GWK37_RS16095	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GWK37_RS16100	COG0586	Pfam SNARE associated Golgi protein
GWK37_RS16105	COG0861	Integral membrane protein TerC family
GWK37_RS16110	COG1191	sigma factor activity
GWK37_RS16135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK37_RS16140	COG2323	membrane
GWK37_RS16150	COG3594	Acyltransferase
GWK37_RS16155	COG5002	protein histidine kinase activity
GWK37_RS16160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK37_RS16175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK37_RS16180	COG0436	Aminotransferase
GWK37_RS16210	COG3852	Histidine kinase
GWK37_RS16215	COG1846	Transcriptional regulator
GWK37_RS16220	COG1360	Flagellar Motor Protein
GWK37_RS16225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWK37_RS16230	COG0542	response to heat
GWK37_RS16235	COG3949	Membrane
GWK37_RS16250	COG0720	synthase
GWK37_RS16255	COG0602	queuosine metabolic process
GWK37_RS16265	COG1733	regulation of RNA biosynthetic process
GWK37_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS16285	COG4873	Protein conserved in bacteria
GWK37_RS16295	COG3773	Cell wall hydrolase
GWK37_RS16300	COG2244	polysaccharide biosynthetic process
GWK37_RS16305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS16310	COG2217	Heavy metal translocating P-type atpase
GWK37_RS16315	COG0006	proline dipeptidase activity
GWK37_RS16320	COG1609	Transcriptional regulator
GWK37_RS16325	COG3711	transcriptional antiterminator
GWK37_RS16330	COG1263	PTS System
GWK37_RS16330	COG2190	(PTS) system
GWK37_RS16330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWK37_RS16335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS16340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWK37_RS16350	COG1533	DNA photolyase activity
GWK37_RS16355	COG0840	transmembrane signaling receptor activity
GWK37_RS16360	COG2084	Dehydrogenase
GWK37_RS16375	COG0347	Belongs to the P(II) protein family
GWK37_RS16380	COG2340	Cysteine-rich secretory protein family
GWK37_RS16385	COG0768	penicillin binding
GWK37_RS16390	COG4191	Histidine kinase
GWK37_RS16395	COG0436	Aminotransferase
GWK37_RS16400	COG0835	chemotaxis
GWK37_RS16400	COG0784	Response regulator, receiver
GWK37_RS16410	COG2814	Major facilitator Superfamily
GWK37_RS16415	COG1376	ErfK ybiS ycfS ynhG family protein
GWK37_RS16420	COG1408	metallophosphoesterase
GWK37_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS16435	COG2200	EAL domain
GWK37_RS16440	COG4703	Protein of unknown function (DUF1797)
GWK37_RS16445	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GWK37_RS16455	COG0517	IMP dehydrogenase activity
GWK37_RS16460	COG0583	DNA-binding transcription factor activity
GWK37_RS16465	COG0716	FMN binding
GWK37_RS16475	COG0716	FMN binding
GWK37_RS16495	COG0668	transmembrane transport
GWK37_RS16500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS16520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK37_RS16525	COG0303	'Molybdopterin
GWK37_RS16530	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWK37_RS16535	COG0314	molybdopterin synthase activity
GWK37_RS16540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWK37_RS16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK37_RS16555	COG1136	(ABC) transporter
GWK37_RS16560	COG0577	efflux transmembrane transporter activity
GWK37_RS16565	COG1349	DNA-binding transcription factor activity
GWK37_RS16570	COG1105	Belongs to the carbohydrate kinase PfkB family
GWK37_RS16575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK37_RS16575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK37_RS16575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK37_RS16580	COG0681	Belongs to the peptidase S26 family
GWK37_RS16590	COG0488	(ABC) transporter
GWK37_RS16595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK37_RS16600	COG2309	aminopeptidase activity
GWK37_RS16610	COG1077	Cell shape determining protein MreB Mrl
GWK37_RS16615	COG2002	toxin-antitoxin pair type II binding
GWK37_RS16620	COG3852	Histidine kinase
GWK37_RS16625	COG2105	PFAM AIG2 family protein
GWK37_RS16625	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GWK37_RS16630	COG0569	domain protein
GWK37_RS16640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK37_RS16650	COG0561	phosphatase activity
GWK37_RS16655	COG0242	peptide deformylase activity
GWK37_RS16665	COG0497	DNA recombination
GWK37_RS16675	COG3321	synthase
GWK37_RS16675	COG4221	oxidoreductase activity
GWK37_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS16675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS16680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS16680	COG0300	oxidoreductase activity
GWK37_RS16680	COG3321	synthase
GWK37_RS16680	COG4221	oxidoreductase activity
GWK37_RS16685	COG3321	synthase
GWK37_RS16685	COG4221	oxidoreductase activity
GWK37_RS16685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS16690	COG4221	oxidoreductase activity
GWK37_RS16690	COG0300	oxidoreductase activity
GWK37_RS16690	COG3321	synthase
GWK37_RS16690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS16695	COG4221	oxidoreductase activity
GWK37_RS16695	COG3321	synthase
GWK37_RS16695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS16695	COG0300	oxidoreductase activity
GWK37_RS16700	COG4221	oxidoreductase activity
GWK37_RS16700	COG3321	synthase
GWK37_RS16700	COG0300	oxidoreductase activity
GWK37_RS16700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS16705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS16705	COG3321	synthase
GWK37_RS16705	COG4221	oxidoreductase activity
GWK37_RS16710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK37_RS16715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK37_RS16720	COG0022	dehydrogenase e1 component
GWK37_RS16725	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK37_RS16730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK37_RS16735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS16750	COG1982	Orn Lys Arg decarboxylase major
GWK37_RS16770	COG0483	inositol monophosphate 1-phosphatase activity
GWK37_RS16780	COG3227	Zinc metalloprotease (Elastase)
GWK37_RS16795	COG1595	DNA-templated transcription, initiation
GWK37_RS16825	COG4896	Protein conserved in bacteria
GWK37_RS16835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWK37_RS16840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GWK37_RS16845	COG2066	Belongs to the glutaminase family
GWK37_RS16855	COG0772	Belongs to the SEDS family
GWK37_RS16860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GWK37_RS16875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK37_RS16875	COG2010	Cytochrome c
GWK37_RS16880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK37_RS16885	COG1845	cytochrome c oxidase, subunit III
GWK37_RS16890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK37_RS16895	COG3336	cytochrome c oxidase
GWK37_RS16905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GWK37_RS16910	COG2340	Cysteine-rich secretory protein family
GWK37_RS16925	COG3679	Belongs to the UPF0342 family
GWK37_RS16935	COG0742	ribosomal rna small subunit methyltransferase
GWK37_RS16945	COG3314	Sporulation integral membrane protein YlbJ
GWK37_RS16950	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK37_RS16955	COG3480	Lon protease (S16) C-terminal proteolytic domain
GWK37_RS16965	COG1399	metal-binding, possibly nucleic acid-binding protein
GWK37_RS16970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWK37_RS16985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWK37_RS17005	COG4839	cell division protein FtsL
GWK37_RS17015	COG0768	penicillin binding
GWK37_RS17035	COG0772	Belongs to the SEDS family
GWK37_RS17050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWK37_RS17055	COG0849	cell division
GWK37_RS17060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK37_RS17065	COG1404	Belongs to the peptidase S8 family
GWK37_RS17065	COG4412	M6 family metalloprotease domain protein
GWK37_RS17075	COG1191	sigma factor activity
GWK37_RS17080	COG1191	sigma factor activity
GWK37_RS17085	COG1119	ATPase activity
GWK37_RS17090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK37_RS17095	COG1873	PFAM PRC-barrel domain
GWK37_RS17105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWK37_RS17115	COG0762	integral membrane protein
GWK37_RS17120	COG2302	S4 RNA-binding domain
GWK37_RS17125	COG3599	regulation of cell shape
GWK37_RS17130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK37_RS17135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK37_RS17145	COG0564	pseudouridine synthase activity
GWK37_RS17155	COG2233	PERMEase
GWK37_RS17165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWK37_RS17170	COG0505	Belongs to the CarA family
GWK37_RS17175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK37_RS17190	COG0284	orotidine-5'-phosphate decarboxylase activity
GWK37_RS17195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWK37_RS17205	COG0306	phosphate transporter
GWK37_RS17220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK37_RS17225	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GWK37_RS17230	COG1648	precorrin-2 dehydrogenase activity
GWK37_RS17240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK37_RS17245	COG1561	YicC-like family, N-terminal region
GWK37_RS17250	COG2052	Domain of unknown function (DUF370)
GWK37_RS17255	COG0194	GDP metabolic process
GWK37_RS17265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK37_RS17270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK37_RS17275	COG0242	peptide deformylase activity
GWK37_RS17285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWK37_RS17285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK37_RS17295	COG0631	protein serine/threonine phosphatase activity
GWK37_RS17300	COG0515	serine threonine protein kinase
GWK37_RS17300	COG2815	serine threonine protein kinase
GWK37_RS17310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWK37_RS17315	COG1564	THIamine pyrophosphokinase
GWK37_RS17330	COG1302	Protein conserved in bacteria
GWK37_RS17335	COG1461	Dihydroxyacetone kinase
GWK37_RS17340	COG1760	l-serine dehydratase
GWK37_RS17345	COG1760	l-serine dehydratase
GWK37_RS17350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK37_RS17365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK37_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS17375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS17385	COG1196	nuclear chromosome segregation
GWK37_RS17390	COG0552	protein localization to endoplasmic reticulum
GWK37_RS17405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK37_RS17415	COG1837	Belongs to the UPF0109 family
GWK37_RS17440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWK37_RS17455	COG2257	FlhB HrpN YscU SpaS Family
GWK37_RS17465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWK37_RS17470	COG0758	DNA mediated transformation
GWK37_RS17475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK37_RS17485	COG4974	Belongs to the 'phage' integrase family
GWK37_RS17505	COG1815	bacterial-type flagellum-dependent cell motility
GWK37_RS17510	COG1558	bacterial-type flagellum-dependent cell motility
GWK37_RS17515	COG1677	Flagellar hook-basal body complex protein FliE
GWK37_RS17520	COG1766	The M ring may be actively involved in energy transduction
GWK37_RS17525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK37_RS17530	COG1317	bacterial-type flagellum organization
GWK37_RS17535	COG1157	protein secretion by the type III secretion system
GWK37_RS17540	COG2882	bacterial-type flagellum organization
GWK37_RS17545	COG3334	PFAM MgtE intracellular
GWK37_RS17550	COG3144	bacterial-type flagellum assembly
GWK37_RS17555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWK37_RS17560	COG4786	Flagellar basal body rod
GWK37_RS17565	COG1582	Flagellar protein (FlbD)
GWK37_RS17570	COG1580	Controls the rotational direction of flagella during chemotaxis
GWK37_RS17575	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK37_RS17580	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWK37_RS17580	COG1776	CheC inhibitor of MCP methylation
GWK37_RS17585	COG2201	protein-glutamate methylesterase activity
GWK37_RS17590	COG3190	flagellar
GWK37_RS17595	COG1338	Plays a role in the flagellum-specific transport system
GWK37_RS17600	COG1987	bacterial-type flagellum assembly
GWK37_RS17605	COG1684	flagellar biosynthetic protein fliR
GWK37_RS17610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWK37_RS17615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWK37_RS17620	COG1419	protein localization to endoplasmic reticulum
GWK37_RS17625	COG0455	bacterial-type flagellum organization
GWK37_RS17630	COG2201	protein-glutamate methylesterase activity
GWK37_RS17635	COG2198	Histidine kinase
GWK37_RS17635	COG0643	Histidine kinase
GWK37_RS17640	COG0835	chemotaxis
GWK37_RS17645	COG1776	CheC inhibitor of MCP methylation
GWK37_RS17655	COG1191	sigma factor activity
GWK37_RS17685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK37_RS17690	COG4589	Belongs to the CDS family
GWK37_RS17700	COG0750	zinc metalloprotease
GWK37_RS17710	COG2176	DNA-directed DNA polymerase activity
GWK37_RS17720	COG0195	Participates in both transcription termination and antitermination
GWK37_RS17725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GWK37_RS17730	COG1358	cellular component organization or biogenesis
GWK37_RS17740	COG1550	Protein conserved in bacteria
GWK37_RS17755	COG0196	riboflavin kinase activity
GWK37_RS17770	COG0726	polysaccharide deacetylase
GWK37_RS17775	COG0612	Peptidase, M16
GWK37_RS17780	COG1873	PFAM PRC-barrel domain
GWK37_RS17785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK37_RS17790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK37_RS17795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWK37_RS17800	COG0527	aspartate kinase activity
GWK37_RS17810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK37_RS17815	COG0740	serine-type endopeptidase activity
GWK37_RS17825	COG1674	ftsk spoiiie
GWK37_RS17825	COG4980	gas vesicle protein
GWK37_RS17830	COG2188	Transcriptional regulator
GWK37_RS17835	COG2814	Major facilitator Superfamily
GWK37_RS17840	COG1846	Transcriptional regulator
GWK37_RS17845	COG2409	Drug exporters of the RND superfamily
GWK37_RS17845	COG1033	growth of symbiont in host cell
GWK37_RS17850	COG0612	Peptidase, M16
GWK37_RS17855	COG0612	Peptidase, M16
GWK37_RS17860	COG0300	oxidoreductase activity
GWK37_RS17875	COG1426	Protein conserved in bacteria
GWK37_RS17880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK37_RS17895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK37_RS17905	COG1692	metallophosphoesterase
GWK37_RS17910	COG2359	stage V sporulation protein S
GWK37_RS17930	COG4550	Control of competence regulator ComK, YlbF/YmcA
GWK37_RS18000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS18005	COG3425	synthase
GWK37_RS18010	COG1024	Enoyl-CoA hydratase
GWK37_RS18015	COG1024	Enoyl-CoA hydratase
GWK37_RS18020	COG3321	synthase
GWK37_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18020	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS18020	COG0300	oxidoreductase activity
GWK37_RS18025	COG4221	oxidoreductase activity
GWK37_RS18025	COG3321	synthase
GWK37_RS18025	COG0300	oxidoreductase activity
GWK37_RS18025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS18030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS18030	COG3321	synthase
GWK37_RS18030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS18030	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK37_RS18030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS18030	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18030	COG3321	synthase
GWK37_RS18030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18035	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18035	COG3321	synthase
GWK37_RS18035	COG4221	oxidoreductase activity
GWK37_RS18040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK37_RS18040	COG3321	synthase
GWK37_RS18040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWK37_RS18040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWK37_RS18045	COG2124	cytochrome p450
GWK37_RS18050	COG3209	COG3209 Rhs family protein
GWK37_RS18055	COG3619	membrane
GWK37_RS18065	COG1404	Belongs to the peptidase S8 family
GWK37_RS18075	COG4195	phage-related replication protein
GWK37_RS18080	COG1764	response to oxidative stress
GWK37_RS18090	COG2076	Multidrug Resistance protein
GWK37_RS18130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK37_RS18135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK37_RS18140	COG4112	unkown
GWK37_RS18145	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWK37_RS18155	COG0464	growth
GWK37_RS18160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK37_RS18165	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GWK37_RS18170	COG0789	Transcriptional regulator
GWK37_RS18175	COG0174	glutamine synthetase
GWK37_RS18180	COG2211	Major facilitator Superfamily
GWK37_RS18185	COG3507	Belongs to the glycosyl hydrolase 43 family
GWK37_RS18200	COG1070	Carbohydrate kinase
GWK37_RS18205	COG0574	Belongs to the PEP-utilizing enzyme family
GWK37_RS18205	COG3848	Pyruvate phosphate dikinase
GWK37_RS18225	COG2378	regulation of single-species biofilm formation
GWK37_RS18230	COG2318	DinB family
GWK37_RS18235	COG1064	alcohol dehydrogenase
GWK37_RS18255	COG0456	acetyltransferase
GWK37_RS18260	COG5444	nuclease activity
GWK37_RS18295	COG3397	chitin binding
GWK37_RS18305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWK37_RS18315	COG5434	Belongs to the glycosyl hydrolase 28 family
GWK37_RS18320	COG0756	dUTP diphosphatase activity
GWK37_RS18325	COG4195	phage-related replication protein
GWK37_RS18355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK37_RS18365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWK37_RS18385	COG0785	Cytochrome C biogenesis protein
GWK37_RS18390	COG2201	protein-glutamate methylesterase activity
GWK37_RS18395	COG4846	Membrane protein involved in cytochrome C biogenesis
GWK37_RS18405	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK37_RS18420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK37_RS18425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWK37_RS18445	COG0824	Thioesterase
GWK37_RS18455	COG4841	protein insertion into membrane
GWK37_RS18465	COG1832	CoA-binding protein
GWK37_RS18470	COG0187	DNA topoisomerase II activity
GWK37_RS18475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK37_RS18485	COG1115	amino acid carrier protein
GWK37_RS18495	COG1063	alcohol dehydrogenase
GWK37_RS18500	COG0800	Aldolase
GWK37_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18515	COG1609	Transcriptional regulator
GWK37_RS18520	COG2271	Major facilitator Superfamily
GWK37_RS18560	COG2205	protein histidine kinase activity
GWK37_RS18565	COG0745	RESPONSE REGULATOR receiver
GWK37_RS18600	COG1028	Short-chain dehydrogenase reductase Sdr
GWK37_RS18605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK37_RS18610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK37_RS18615	COG2610	gluconate transmembrane transporter activity
GWK37_RS18620	COG2124	cytochrome p450
GWK37_RS18625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWK37_RS18640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWK37_RS18650	COG2246	polysaccharide biosynthetic process
GWK37_RS18655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK37_RS18660	COG0586	Pfam SNARE associated Golgi protein
GWK37_RS18665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK37_RS18670	COG1024	Enoyl-CoA hydratase
GWK37_RS18675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK37_RS18680	COG0511	ligase activity, forming carbon-carbon bonds
GWK37_RS18685	COG0439	Biotin carboxylase
GWK37_RS18690	COG0318	PFAM AMP-dependent synthetase and ligase
GWK37_RS18695	COG1960	acyl-CoA dehydrogenase activity
GWK37_RS18710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18710	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWK37_RS18715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK37_RS18735	COG2027	D-alanyl-D-alanine carboxypeptidase
GWK37_RS18740	COG2017	converts alpha-aldose to the beta-anomer
GWK37_RS18745	COG0534	Mate efflux family protein
GWK37_RS18760	COG0582	viral genome integration into host DNA
GWK37_RS18765	COG0166	Belongs to the GPI family
GWK37_RS18770	COG0405	Gamma-glutamyltransferase
GWK37_RS18775	COG2814	Major facilitator Superfamily
GWK37_RS18780	COG0640	Transcriptional regulator
GWK37_RS18785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWK37_RS18795	COG0604	alcohol dehydrogenase
GWK37_RS18805	COG0493	'glutamate synthase
GWK37_RS18810	COG0069	glutamate synthase activity
GWK37_RS18810	COG0067	glutamate synthase
GWK37_RS18810	COG0070	glutamate synthase
GWK37_RS18815	COG0583	DNA-binding transcription factor activity
GWK37_RS18820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GWK37_RS18835	COG0300	oxidoreductase activity
GWK37_RS18840	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GWK37_RS18850	COG2814	Major facilitator Superfamily
GWK37_RS18855	COG1070	Carbohydrate kinase
GWK37_RS18860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK37_RS18865	COG0243	molybdopterin cofactor binding
GWK37_RS18895	COG5444	nuclease activity
GWK37_RS18900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK37_RS18905	COG2207	Transcriptional regulator
GWK37_RS18905	COG0662	Cupin 2, conserved barrel domain protein
GWK37_RS18910	COG1309	transcriptional regulator
GWK37_RS18915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS18925	COG0640	Transcriptional regulator
GWK37_RS18930	COG0741	lytic transglycosylase activity
GWK37_RS18935	COG2322	membrane
GWK37_RS18950	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWK37_RS18960	COG3584	3D domain protein
GWK37_RS18960	COG1388	LysM domain
GWK37_RS18965	COG0514	ATP-dependent DNA helicase (RecQ)
GWK37_RS18975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWK37_RS18980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK37_RS18995	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK37_RS19025	COG1012	belongs to the aldehyde dehydrogenase family
GWK37_RS19030	COG1657	PFAM Prenyltransferase squalene oxidase
GWK37_RS19035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK37_RS19040	COG0733	neurotransmitter:sodium symporter activity
GWK37_RS19045	COG0385	Bile acid
GWK37_RS19050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK37_RS19055	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK37_RS19065	COG4548	von Willebrand factor, type A
GWK37_RS19070	COG0714	Associated with various cellular activities
GWK37_RS19075	COG2032	superoxide dismutase activity
GWK37_RS19080	COG1388	LysM domain
GWK37_RS19080	COG0791	NLP P60 protein
GWK37_RS19085	COG1819	glycosyl
GWK37_RS19090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWK37_RS19095	COG0534	Mate efflux family protein
GWK37_RS19100	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK37_RS19105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK37_RS19110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWK37_RS19120	COG2962	Rard protein
GWK37_RS19135	COG1942	4-Oxalocrotonate Tautomerase
GWK37_RS19145	COG1733	regulation of RNA biosynthetic process
GWK37_RS19150	COG0778	Nitroreductase
GWK37_RS19155	COG0400	carboxylic ester hydrolase activity
GWK37_RS19160	COG0346	lactoylglutathione lyase activity
GWK37_RS19170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK37_RS19180	COG2723	6-phospho-beta-galactosidase activity
GWK37_RS19185	COG2188	Transcriptional regulator
GWK37_RS19190	COG0793	Belongs to the peptidase S41A family
GWK37_RS19190	COG3409	Peptidoglycan-binding domain 1 protein
GWK37_RS19195	COG2226	methyltransferase
GWK37_RS19205	COG1876	peptidase activity
GWK37_RS19225	COG0671	phosphoesterase, PA-phosphatase related
GWK37_RS19255	COG1509	lysine 2,3-aminomutase activity
GWK37_RS19260	COG0456	acetyltransferase
GWK37_RS19265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK37_RS19270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK37_RS19275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK37_RS19280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWK37_RS19295	COG0456	acetyltransferase
GWK37_RS19300	COG0463	Glycosyl transferase, family 2
GWK37_RS19315	COG4641	Protein conserved in bacteria
GWK37_RS19325	COG1086	Polysaccharide biosynthesis protein
GWK37_RS19345	COG1388	LysM domain
GWK37_RS19350	COG0457	Tetratricopeptide repeat
GWK37_RS19360	COG3391	amine dehydrogenase activity
GWK37_RS19410	COG3655	Transcriptional regulator
GWK37_RS19445	COG5444	nuclease activity
GWK37_RS19455	COG1525	nuclease
GWK37_RS19470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK37_RS19490	COG1846	Transcriptional regulator
GWK37_RS19495	COG4698	Protein conserved in bacteria
GWK37_RS19500	COG2755	lipolytic protein G-D-S-L family
GWK37_RS19505	COG1999	signal sequence binding
GWK37_RS19515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK37_RS19520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWK37_RS19525	COG1272	protein, Hemolysin III
GWK37_RS19530	COG0204	Acyl-transferase
GWK37_RS19535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWK37_RS19550	COG2521	methyltransferase
GWK37_RS19550	COG2136	Putative SAM-dependent methyltransferase
GWK37_RS19565	COG1413	lyase activity
GWK37_RS19570	COG1418	mRNA catabolic process
GWK37_RS19575	COG0386	Belongs to the glutathione peroxidase family