locus-tag	class	description
CXR48_RS00010	COG0592	DNA-directed DNA polymerase activity
CXR48_RS00015	COG2501	S4 domain
CXR48_RS00030	COG0187	DNA topoisomerase II activity
CXR48_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR48_RS00070	COG0516	GMP reductase activity
CXR48_RS00070	COG0517	IMP dehydrogenase activity
CXR48_RS00075	COG1686	Belongs to the peptidase S11 family
CXR48_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
CXR48_RS00105	COG1428	Deoxynucleoside kinase
CXR48_RS00110	COG1428	Deoxynucleoside kinase
CXR48_RS00115	COG3858	chitin binding
CXR48_RS00115	COG1388	LysM domain
CXR48_RS00120	COG1335	isochorismatase
CXR48_RS00125	COG0590	tRNA wobble adenosine to inosine editing
CXR48_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXR48_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXR48_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CXR48_RS00195	COG3853	Toxic anion resistance protein (TelA)
CXR48_RS00200	COG1982	Orn Lys Arg decarboxylase major
CXR48_RS00210	COG3870	Protein conserved in bacteria
CXR48_RS00215	COG1728	Protein conserved in bacteria
CXR48_RS00220	COG0470	DNA polymerase III
CXR48_RS00225	COG1774	PSP1 C-terminal conserved region
CXR48_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CXR48_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CXR48_RS00250	COG2002	toxin-antitoxin pair type II binding
CXR48_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR48_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR48_RS00260	COG0084	hydrolase, TatD family'
CXR48_RS00265	COG3583	domain protein
CXR48_RS00265	COG3584	3D domain protein
CXR48_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CXR48_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR48_RS00285	COG4466	Protein conserved in bacteria
CXR48_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXR48_RS00305	COG0251	oxidation-reduction process
CXR48_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXR48_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXR48_RS00345	COG2002	toxin-antitoxin pair type II binding
CXR48_RS00350	COG2244	polysaccharide biosynthetic process
CXR48_RS00355	COG3956	TIGRFAM MazG family protein
CXR48_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CXR48_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CXR48_RS00380	COG1098	S1 RNA binding domain
CXR48_RS00395	COG2208	phosphoserine phosphatase activity
CXR48_RS00400	COG2304	oxidoreductase activity
CXR48_RS00405	COG0515	serine threonine protein kinase
CXR48_RS00410	COG0037	tRNA processing
CXR48_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXR48_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXR48_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXR48_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXR48_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CXR48_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
CXR48_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CXR48_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXR48_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CXR48_RS00475	COG1396	sequence-specific DNA binding
CXR48_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXR48_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXR48_RS00565	COG4463	regulation of RNA biosynthetic process
CXR48_RS00570	COG3880	PFAM UvrB UvrC protein
CXR48_RS00580	COG0542	response to heat
CXR48_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CXR48_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CXR48_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
CXR48_RS00620	COG1045	serine acetyltransferase
CXR48_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CXR48_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR48_RS00640	COG3688	RNA-binding protein containing a PIN domain
CXR48_RS00645	COG1595	DNA-templated transcription, initiation
CXR48_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXR48_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
CXR48_RS00685	COG2813	Specifically methylates the guanine in position
CXR48_RS00700	COG1358	cellular component organization or biogenesis
CXR48_RS00725	COG0596	Alpha beta hydrolase
CXR48_RS00835	COG0201	protein transport
CXR48_RS00845	COG0024	Methionine aminopeptidase
CXR48_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXR48_RS00885	COG1122	ATPase activity
CXR48_RS00890	COG1122	ATPase activity
CXR48_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXR48_RS00915	COG2226	methyltransferase
CXR48_RS00920	COG2318	DinB family
CXR48_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS00935	COG0489	protein tyrosine kinase activity
CXR48_RS00945	COG2194	sulfuric ester hydrolase activity
CXR48_RS00950	COG0726	polysaccharide deacetylase
CXR48_RS00970	COG0738	Major facilitator superfamily
CXR48_RS00975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS00990	COG0659	secondary active sulfate transmembrane transporter activity
CXR48_RS00995	COG0385	Bile acid
CXR48_RS01000	COG2819	hydrolase of the alpha beta superfamily
CXR48_RS01005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS01010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS01015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR48_RS01020	COG2207	Transcriptional regulator
CXR48_RS01020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR48_RS01025	COG3876	Protein conserved in bacteria
CXR48_RS01030	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR48_RS01035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR48_RS01040	COG1263	PTS System
CXR48_RS01040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS01050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR48_RS01055	COG1683	Conserved Protein
CXR48_RS01085	COG1595	DNA-templated transcription, initiation
CXR48_RS01090	COG5662	AntiSigma factor
CXR48_RS01095	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CXR48_RS01100	COG4856	YbbR-like protein
CXR48_RS01130	COG1346	cytolysis
CXR48_RS01135	COG1380	Effector of murein hydrolase LrgA
CXR48_RS01140	COG1846	Transcriptional regulator
CXR48_RS01145	COG1113	amino acid transport
CXR48_RS01150	COG1011	Hydrolase
CXR48_RS01155	COG4585	Histidine kinase
CXR48_RS01160	COG2197	response regulator
CXR48_RS01165	COG1131	(ABC) transporter
CXR48_RS01185	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CXR48_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS01205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS01205	COG4221	oxidoreductase activity
CXR48_RS01205	COG3321	synthase
CXR48_RS01210	COG3321	synthase
CXR48_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS01210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS01210	COG0300	oxidoreductase activity
CXR48_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS01250	COG0531	amino acid
CXR48_RS01255	COG0584	glycerophosphoryl diester phosphodiesterase
CXR48_RS01260	COG2271	Major facilitator Superfamily
CXR48_RS01275	COG2368	4-hydroxyphenylacetate
CXR48_RS01285	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS01300	COG0371	Dehydrogenase
CXR48_RS01310	COG1183	phosphatidylcholine synthase activity
CXR48_RS01315	COG0586	Pfam SNARE associated Golgi protein
CXR48_RS01320	COG0688	phosphatidylethanolamine metabolic process
CXR48_RS01335	COG1301	dicarboxylic acid transport
CXR48_RS01340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS01345	COG0833	amino acid
CXR48_RS01350	COG2040	homocysteine
CXR48_RS01355	COG1115	amino acid carrier protein
CXR48_RS01360	COG2066	Belongs to the glutaminase family
CXR48_RS01365	COG4191	Histidine kinase
CXR48_RS01370	COG0784	Response regulator, receiver
CXR48_RS01375	COG3173	Aminoglycoside phosphotransferase
CXR48_RS01385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CXR48_RS01390	COG0778	Nitroreductase
CXR48_RS01395	COG0346	lactoylglutathione lyase activity
CXR48_RS01400	COG2259	Doxx family
CXR48_RS01405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS01425	COG3773	Cell wall hydrolase
CXR48_RS01435	COG3540	Alkaline phosphatase
CXR48_RS01440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR48_RS01445	COG0805	protein transport
CXR48_RS01455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXR48_RS01460	COG0477	Major facilitator Superfamily
CXR48_RS01465	COG1309	transcriptional regulator
CXR48_RS01470	COG0252	asparaginase activity
CXR48_RS01475	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CXR48_RS01480	COG1405	negative regulation of cell septum assembly
CXR48_RS01480	COG3012	SEC-C Motif Domain Protein
CXR48_RS01485	COG0667	Aldo Keto reductase
CXR48_RS01495	COG1595	DNA-templated transcription, initiation
CXR48_RS01500	COG1595	DNA-templated transcription, initiation
CXR48_RS01505	COG1876	peptidase activity
CXR48_RS01510	COG0457	Tetratricopeptide repeat
CXR48_RS01515	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS01520	COG0366	Alpha amylase catalytic
CXR48_RS01525	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXR48_RS01530	COG1121	(ABC) transporter
CXR48_RS01535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXR48_RS01540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS01545	COG2310	stress, protein
CXR48_RS01550	COG2310	stress, protein
CXR48_RS01555	COG2310	stress, protein
CXR48_RS01560	COG0861	Integral membrane protein TerC family
CXR48_RS01570	COG3853	Toxic anion resistance protein (TelA)
CXR48_RS01575	COG0477	Major facilitator Superfamily
CXR48_RS01580	COG4175	Glycine betaine
CXR48_RS01580	COG0517	IMP dehydrogenase activity
CXR48_RS01585	COG4176	ABC-type proline glycine betaine transport system permease component
CXR48_RS01590	COG2113	Glycine betaine
CXR48_RS01595	COG1473	amidohydrolase
CXR48_RS01600	COG1288	antiporter activity
CXR48_RS01610	COG0366	Alpha amylase catalytic
CXR48_RS01625	COG2814	Major facilitator Superfamily
CXR48_RS01630	COG1846	Transcriptional regulator
CXR48_RS01635	COG1280	lysine exporter protein (LysE YggA)
CXR48_RS01640	COG3403	YqcI/YcgG family
CXR48_RS01645	COG1113	amino acid transport
CXR48_RS01650	COG3665	Urea carboxylase-associated protein
CXR48_RS01665	COG1660	Displays ATPase and GTPase activities
CXR48_RS01675	COG2271	Major facilitator Superfamily
CXR48_RS01680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXR48_RS01685	COG3458	cephalosporin-C deacetylase activity
CXR48_RS01690	COG3541	Predicted nucleotidyltransferase
CXR48_RS01695	COG0506	proline dehydrogenase activity
CXR48_RS01700	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS01705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR48_RS01710	COG2508	Transcriptional regulator
CXR48_RS01720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR48_RS01720	COG1587	Uroporphyrinogen-III synthase
CXR48_RS01725	COG2146	nitrite reductase [NAD(P)H] activity
CXR48_RS01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR48_RS01735	COG0523	cobalamin synthesis protein
CXR48_RS01740	COG1063	alcohol dehydrogenase
CXR48_RS01745	COG1714	RDD family
CXR48_RS01765	COG3209	COG3209 Rhs family protein
CXR48_RS01770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CXR48_RS01775	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CXR48_RS01780	COG1733	regulation of RNA biosynthetic process
CXR48_RS01785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS01795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS01800	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CXR48_RS01815	COG2364	Membrane
CXR48_RS01820	COG1126	abc transporter atp-binding protein
CXR48_RS01825	COG0765	amino acid transport
CXR48_RS01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS01835	COG0583	DNA-binding transcription factor activity
CXR48_RS01840	COG0163	prenyltransferase activity
CXR48_RS01845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXR48_RS01860	COG3104	oligopeptide transport
CXR48_RS01865	COG5434	Belongs to the glycosyl hydrolase 28 family
CXR48_RS01875	COG0697	spore germination
CXR48_RS01885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXR48_RS01890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS01895	COG0456	acetyltransferase
CXR48_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS01905	COG0765	amino acid transport
CXR48_RS01910	COG1126	abc transporter atp-binding protein
CXR48_RS01915	COG1473	amidohydrolase
CXR48_RS01920	COG2079	MmgE PrpD family protein
CXR48_RS01925	COG1136	(ABC) transporter
CXR48_RS01930	COG0577	efflux transmembrane transporter activity
CXR48_RS01935	COG0745	RESPONSE REGULATOR receiver
CXR48_RS01940	COG3850	Histidine kinase
CXR48_RS01940	COG5002	protein histidine kinase activity
CXR48_RS01945	COG0457	Tetratricopeptide repeat
CXR48_RS01960	COG0527	aspartate kinase activity
CXR48_RS01970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS01975	COG4605	iron ion homeostasis
CXR48_RS01980	COG4604	ABC transporter, ATP-binding protein
CXR48_RS01985	COG4607	ABC-type enterochelin transport system periplasmic component
CXR48_RS01990	COG2814	Major facilitator Superfamily
CXR48_RS01995	COG1309	transcriptional regulator
CXR48_RS02000	COG0778	Nitroreductase
CXR48_RS02005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CXR48_RS02010	COG0640	Transcriptional regulator
CXR48_RS02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR48_RS02020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS02030	COG4975	Glucose uptake
CXR48_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS02040	COG4549	nuclear export factor GLE1
CXR48_RS02045	COG1276	copper resistance
CXR48_RS02045	COG2372	response to copper ion
CXR48_RS02050	COG1349	DNA-binding transcription factor activity
CXR48_RS02060	COG2213	PTS system mannitol-specific
CXR48_RS02065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS02075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXR48_RS02085	COG0561	phosphatase activity
CXR48_RS02095	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR48_RS02105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXR48_RS02110	COG1984	allophanate hydrolase subunit 2
CXR48_RS02115	COG1414	Transcriptional regulator
CXR48_RS02120	COG2755	lipolytic protein G-D-S-L family
CXR48_RS02130	COG2329	Antibiotic biosynthesis monooxygenase
CXR48_RS02135	COG0768	penicillin binding
CXR48_RS02140	COG4989	oxidoreductase activity
CXR48_RS02145	COG3711	transcriptional antiterminator
CXR48_RS02150	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS02160	COG1917	Cupin 2, conserved barrel domain protein
CXR48_RS02165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR48_RS02170	COG3871	stress protein (general stress protein 26)
CXR48_RS02180	COG2814	Major facilitator Superfamily
CXR48_RS02185	COG1522	sequence-specific DNA binding
CXR48_RS02190	COG0551	DNA topoisomerase type I activity
CXR48_RS02190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXR48_RS02195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CXR48_RS02200	COG3706	GGDEF domain
CXR48_RS02205	COG5298	Protein conserved in bacteria
CXR48_RS02210	COG1215	transferase activity, transferring glycosyl groups
CXR48_RS02220	COG0531	amino acid
CXR48_RS02225	COG0494	nUDIX hydrolase
CXR48_RS02230	COG0028	Belongs to the TPP enzyme family
CXR48_RS02260	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR48_RS02275	COG4876	unkown
CXR48_RS02285	COG2076	Multidrug Resistance protein
CXR48_RS02290	COG2217	Heavy metal translocating P-type atpase
CXR48_RS02295	COG3729	General stress protein
CXR48_RS02300	COG0662	Cupin 2, conserved barrel domain protein
CXR48_RS02305	COG2329	Antibiotic biosynthesis monooxygenase
CXR48_RS02310	COG3546	catalase activity
CXR48_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXR48_RS02320	COG3290	protein histidine kinase activity
CXR48_RS02325	COG4565	transcriptional regulatory protein
CXR48_RS02330	COG1301	dicarboxylic acid transport
CXR48_RS02335	COG0628	permease
CXR48_RS02340	COG1131	(ABC) transporter
CXR48_RS02345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CXR48_RS02355	COG1960	acyl-CoA dehydrogenase activity
CXR48_RS02370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CXR48_RS02375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS02385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXR48_RS02390	COG0513	Belongs to the DEAD box helicase family
CXR48_RS02395	COG3402	PFAM membrane-flanked domain
CXR48_RS02400	COG3428	Bacterial PH domain
CXR48_RS02405	COG0705	Rhomboid family
CXR48_RS02415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXR48_RS02420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXR48_RS02425	COG0864	Transcriptional regulator
CXR48_RS02430	COG2337	Toxic component of a toxin-antitoxin (TA) module
CXR48_RS02435	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS02440	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS02445	COG2172	sigma factor antagonist activity
CXR48_RS02450	COG2208	phosphoserine phosphatase activity
CXR48_RS02455	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS02465	COG1191	sigma factor activity
CXR48_RS02470	COG2208	phosphoserine phosphatase activity
CXR48_RS02475	COG2183	response to ionizing radiation
CXR48_RS02525	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXR48_RS02540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR48_RS02545	COG0477	Major facilitator Superfamily
CXR48_RS02555	COG1764	response to oxidative stress
CXR48_RS02560	COG1846	Transcriptional regulator
CXR48_RS02570	COG1959	2 iron, 2 sulfur cluster binding
CXR48_RS02575	COG2910	NAD(P)H-binding
CXR48_RS02580	COG1278	Cold shock
CXR48_RS02590	COG1937	Protein conserved in bacteria
CXR48_RS02595	COG2210	Belongs to the sulfur carrier protein TusA family
CXR48_RS02600	COG1054	Belongs to the UPF0176 family
CXR48_RS02605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR48_RS02605	COG0425	Belongs to the sulfur carrier protein TusA family
CXR48_RS02610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS02610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR48_RS02615	COG0425	Belongs to the sulfur carrier protein TusA family
CXR48_RS02620	COG0730	response to heat
CXR48_RS02625	COG1794	racemase activity, acting on amino acids and derivatives
CXR48_RS02640	COG3621	Patatin-like phospholipase
CXR48_RS02650	COG0662	Cupin 2, conserved barrel domain protein
CXR48_RS02665	COG0277	FAD linked oxidase domain protein
CXR48_RS02700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR48_RS02725	COG1064	alcohol dehydrogenase
CXR48_RS02730	COG0789	Transcriptional regulator
CXR48_RS02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR48_RS02755	COG2814	Major facilitator Superfamily
CXR48_RS02760	COG1309	transcriptional regulator
CXR48_RS02770	COG5577	PFAM Coat F domain
CXR48_RS02780	COG1063	alcohol dehydrogenase
CXR48_RS02785	COG5577	PFAM Coat F domain
CXR48_RS02795	COG4585	Histidine kinase
CXR48_RS02800	COG2197	response regulator
CXR48_RS02805	COG2409	Drug exporters of the RND superfamily
CXR48_RS02810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXR48_RS02815	COG0488	(ABC) transporter
CXR48_RS02820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR48_RS02825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS02835	COG2814	Major facilitator Superfamily
CXR48_RS02840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR48_RS02850	COG0730	response to heat
CXR48_RS02855	COG0456	acetyltransferase
CXR48_RS02860	COG4978	Transcriptional regulator
CXR48_RS02860	COG0789	Transcriptional regulator
CXR48_RS02865	COG0697	spore germination
CXR48_RS02875	COG2226	methyltransferase
CXR48_RS02895	COG1802	Transcriptional regulator
CXR48_RS02900	COG1819	glycosyl
CXR48_RS02915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR48_RS02920	COG1388	LysM domain
CXR48_RS02925	COG2814	Major facilitator Superfamily
CXR48_RS02930	COG2188	Transcriptional regulator
CXR48_RS02935	COG2186	Transcriptional regulator
CXR48_RS02940	COG2807	transmembrane transport
CXR48_RS02945	COG2076	Multidrug Resistance protein
CXR48_RS02950	COG2076	Multidrug Resistance protein
CXR48_RS02955	COG1309	transcriptional regulator
CXR48_RS02960	COG0531	amino acid
CXR48_RS02970	COG3832	glyoxalase III activity
CXR48_RS02975	COG0604	alcohol dehydrogenase
CXR48_RS02980	COG2814	Major facilitator Superfamily
CXR48_RS03020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CXR48_RS03025	COG0802	atpase or kinase
CXR48_RS03030	COG1214	PFAM Peptidase M22, glycoprotease
CXR48_RS03035	COG0456	acetyltransferase
CXR48_RS03040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXR48_RS03045	COG0488	(ABC) transporter
CXR48_RS03060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR48_RS03065	COG0805	protein transport
CXR48_RS03075	COG1266	CAAX protease self-immunity
CXR48_RS03115	COG0457	Tetratricopeptide repeat
CXR48_RS03120	COG1063	alcohol dehydrogenase
CXR48_RS03125	COG2211	Major facilitator Superfamily
CXR48_RS03130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR48_RS03140	COG1842	Phage shock protein A
CXR48_RS03145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXR48_RS03150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXR48_RS03155	COG4260	virion core protein, lumpy skin disease virus
CXR48_RS03160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CXR48_RS03160	COG2755	lipolytic protein G-D-S-L family
CXR48_RS03170	COG1595	DNA-templated transcription, initiation
CXR48_RS03175	COG1063	alcohol dehydrogenase
CXR48_RS03180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXR48_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
CXR48_RS03200	COG2132	Multicopper oxidase
CXR48_RS03205	COG1113	amino acid transport
CXR48_RS03210	COG0714	Associated with various cellular activities
CXR48_RS03215	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CXR48_RS03220	COG1305	Transglutaminase-like
CXR48_RS03240	COG2252	PERMEase
CXR48_RS03245	COG3064	Membrane
CXR48_RS03265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXR48_RS03270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CXR48_RS03275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR48_RS03280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXR48_RS03285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR48_RS03300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CXR48_RS03310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXR48_RS03315	COG0138	bifunctional purine biosynthesis protein purh
CXR48_RS03320	COG0151	Belongs to the GarS family
CXR48_RS03330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CXR48_RS03335	COG1470	cell adhesion involved in biofilm formation
CXR48_RS03340	COG4496	protein, YerC YecD
CXR48_RS03345	COG0069	glutamate synthase activity
CXR48_RS03360	COG0210	DNA helicase
CXR48_RS03370	COG4851	CamS sex pheromone cAM373 precursor
CXR48_RS03375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CXR48_RS03380	COG1285	pathogenesis
CXR48_RS03385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR48_RS03405	COG1309	transcriptional regulator
CXR48_RS03410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXR48_RS03415	COG1597	lipid kinase activity
CXR48_RS03420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR48_RS03430	COG1131	(ABC) transporter
CXR48_RS03470	COG5444	nuclease activity
CXR48_RS03500	COG3546	catalase activity
CXR48_RS03505	COG0454	-acetyltransferase
CXR48_RS03515	COG2323	membrane
CXR48_RS03520	COG2329	Antibiotic biosynthesis monooxygenase
CXR48_RS03525	COG0346	lactoylglutathione lyase activity
CXR48_RS03530	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS03535	COG5583	Uncharacterized small protein (DUF2292)
CXR48_RS03540	COG0196	riboflavin kinase activity
CXR48_RS03545	COG0670	Belongs to the BI1 family
CXR48_RS03550	COG1846	Transcriptional regulator
CXR48_RS03555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR48_RS03565	COG2124	cytochrome p450
CXR48_RS03565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXR48_RS03570	COG1368	sulfuric ester hydrolase activity
CXR48_RS03575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXR48_RS03580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS03585	COG1442	glycosyl transferase family 8
CXR48_RS03590	COG1216	Glycosyl transferase, family 2
CXR48_RS03595	COG1442	glycosyl transferase family 8
CXR48_RS03600	COG2223	nitrite transmembrane transporter activity
CXR48_RS03605	COG0531	amino acid
CXR48_RS03610	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS03615	COG0840	transmembrane signaling receptor activity
CXR48_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS03625	COG0457	Tetratricopeptide repeat
CXR48_RS03625	COG0463	Glycosyl transferase, family 2
CXR48_RS03630	COG0488	(ABC) transporter
CXR48_RS03635	COG0789	Transcriptional regulator
CXR48_RS03640	COG2814	Major facilitator Superfamily
CXR48_RS03645	COG0488	(ABC) transporter
CXR48_RS03650	COG0513	Belongs to the DEAD box helicase family
CXR48_RS03660	COG2130	NADP-dependent
CXR48_RS03675	COG3866	Pectate lyase
CXR48_RS03680	COG0471	metal ion transport
CXR48_RS03695	COG2972	Histidine kinase
CXR48_RS03695	COG0745	RESPONSE REGULATOR receiver
CXR48_RS03700	COG3279	Response regulator of the LytR AlgR family
CXR48_RS03710	COG3764	Sortase (surface protein transpeptidase)
CXR48_RS03715	COG3290	protein histidine kinase activity
CXR48_RS03720	COG4565	transcriptional regulatory protein
CXR48_RS03725	COG3181	Tripartite tricarboxylate transporter family receptor
CXR48_RS03730	COG2851	Citrate transporter
CXR48_RS03735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS03740	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CXR48_RS03750	COG2258	MOSC domain
CXR48_RS03770	COG0024	Methionine aminopeptidase
CXR48_RS03775	COG1263	PTS System
CXR48_RS03775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS03785	COG1368	sulfuric ester hydrolase activity
CXR48_RS03795	COG0071	Belongs to the small heat shock protein (HSP20) family
CXR48_RS03810	COG1263	PTS System
CXR48_RS03810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS03815	COG0366	Alpha amylase catalytic
CXR48_RS03820	COG2188	Transcriptional regulator
CXR48_RS03825	COG0778	Nitroreductase
CXR48_RS03840	COG0737	Belongs to the 5'-nucleotidase family
CXR48_RS03845	COG0693	protein deglycase activity
CXR48_RS03850	COG1609	Transcriptional regulator
CXR48_RS03865	COG2814	Major facilitator Superfamily
CXR48_RS03875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR48_RS03880	COG4980	gas vesicle protein
CXR48_RS03885	COG1295	ribonuclease BN
CXR48_RS03890	COG0477	Major facilitator Superfamily
CXR48_RS03895	COG0387	Pfam Sodium calcium exchanger
CXR48_RS03905	COG0668	transmembrane transport
CXR48_RS03910	COG0535	radical SAM domain protein
CXR48_RS03920	COG0726	polysaccharide deacetylase
CXR48_RS03925	COG2084	Dehydrogenase
CXR48_RS03935	COG0598	Magnesium transport protein CorA
CXR48_RS03940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CXR48_RS03945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR48_RS03955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXR48_RS03960	COG4637	Psort location Cytoplasmic, score
CXR48_RS03965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXR48_RS03970	COG0022	dehydrogenase e1 component
CXR48_RS03975	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR48_RS03980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR48_RS03985	COG3284	Transcriptional regulator
CXR48_RS03995	COG1486	melibiose metabolic process
CXR48_RS04000	COG1737	Transcriptional regulator
CXR48_RS04005	COG1263	PTS System
CXR48_RS04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS04010	COG1132	(ABC) transporter
CXR48_RS04015	COG1132	(ABC) transporter
CXR48_RS04020	COG2259	Doxx family
CXR48_RS04025	COG2514	catechol 2,3-dioxygenase activity
CXR48_RS04040	COG1695	Transcriptional regulator
CXR48_RS04045	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXR48_RS04050	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CXR48_RS04055	COG0574	Belongs to the PEP-utilizing enzyme family
CXR48_RS04055	COG3848	Pyruvate phosphate dikinase
CXR48_RS04060	COG2732	(Barnase) inhibitor
CXR48_RS04065	COG2318	DinB family
CXR48_RS04070	COG2814	Major facilitator Superfamily
CXR48_RS04075	COG1846	Transcriptional regulator
CXR48_RS04080	COG0392	lysyltransferase activity
CXR48_RS04080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CXR48_RS04085	COG0384	phenazine biosynthesis protein PhzF
CXR48_RS04090	COG0778	Nitroreductase
CXR48_RS04105	COG1090	epimerase
CXR48_RS04120	COG2814	Major facilitator Superfamily
CXR48_RS04130	COG3591	Belongs to the peptidase S1B family
CXR48_RS04145	COG3103	Sh3 type 3 domain protein
CXR48_RS04150	COG5658	integral membrane protein
CXR48_RS04155	COG0596	Alpha beta hydrolase
CXR48_RS04160	COG0463	Glycosyl transferase, family 2
CXR48_RS04165	COG4485	Bacterial membrane protein, YfhO
CXR48_RS04170	COG1988	membrane-bound metal-dependent
CXR48_RS04175	COG1194	a g-specific adenine glycosylase
CXR48_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS04205	COG1132	(ABC) transporter
CXR48_RS04210	COG4129	membrane
CXR48_RS04220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXR48_RS04225	COG0735	belongs to the Fur family
CXR48_RS04340	COG3340	Belongs to the peptidase S51 family
CXR48_RS04350	COG0277	FAD linked oxidase domain protein
CXR48_RS04360	COG0747	negative chemotaxis
CXR48_RS04365	COG0601	transmembrane transport
CXR48_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR48_RS04375	COG0444	Belongs to the ABC transporter superfamily
CXR48_RS04380	COG4608	Belongs to the ABC transporter superfamily
CXR48_RS04385	COG0753	catalase activity
CXR48_RS04395	COG1116	anion transmembrane transporter activity
CXR48_RS04400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXR48_RS04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR48_RS04425	COG1476	TRANSCRIPTIONal
CXR48_RS04435	COG3382	B3 4 domain protein
CXR48_RS04440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXR48_RS04450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CXR48_RS04455	COG0789	Transcriptional regulator
CXR48_RS04460	COG1664	Polymer-forming cytoskeletal
CXR48_RS04465	COG1664	Polymer-forming cytoskeletal
CXR48_RS04470	COG2766	serine protein kinase
CXR48_RS04485	COG1846	Transcriptional regulator
CXR48_RS04490	COG1566	PFAM secretion protein HlyD family protein
CXR48_RS04495	COG2814	Major facilitator Superfamily
CXR48_RS04500	COG0655	NAD(P)H dehydrogenase (quinone) activity
CXR48_RS04515	COG1725	Transcriptional regulator
CXR48_RS04520	COG1131	(ABC) transporter
CXR48_RS04525	COG1131	(ABC) transporter
CXR48_RS04530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CXR48_RS04535	COG1278	Cold shock
CXR48_RS04545	COG1464	Belongs to the NlpA lipoprotein family
CXR48_RS04550	COG3706	GGDEF domain
CXR48_RS04555	COG1823	symporter activity
CXR48_RS04575	COG5577	PFAM Coat F domain
CXR48_RS04580	COG4085	toxin activity
CXR48_RS04580	COG1525	nuclease
CXR48_RS04580	COG0737	Belongs to the 5'-nucleotidase family
CXR48_RS04585	COG3764	Sortase (surface protein transpeptidase)
CXR48_RS04590	COG0564	pseudouridine synthase activity
CXR48_RS04600	COG0517	IMP dehydrogenase activity
CXR48_RS04605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR48_RS04610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR48_RS04610	COG3153	acetyltransferase
CXR48_RS04615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR48_RS04620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CXR48_RS04625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXR48_RS04635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CXR48_RS04640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR48_RS04655	COG0431	NADPH-dependent FMN reductase
CXR48_RS04670	COG0791	NLP P60 protein
CXR48_RS04670	COG1388	LysM domain
CXR48_RS04675	COG1959	2 iron, 2 sulfur cluster binding
CXR48_RS04680	COG0668	transmembrane transport
CXR48_RS04685	COG2719	SpoVR family
CXR48_RS04690	COG1785	Belongs to the alkaline phosphatase family
CXR48_RS04695	COG1388	LysM domain
CXR48_RS04695	COG0791	NLP P60 protein
CXR48_RS04700	COG0583	DNA-binding transcription factor activity
CXR48_RS04705	COG0372	Belongs to the citrate synthase family
CXR48_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS04715	COG0531	amino acid
CXR48_RS04720	COG0733	neurotransmitter:sodium symporter activity
CXR48_RS04735	COG1595	DNA-templated transcription, initiation
CXR48_RS04740	COG0204	Acyl-transferase
CXR48_RS04745	COG1253	flavin adenine dinucleotide binding
CXR48_RS04750	COG0789	Transcriptional regulator
CXR48_RS04755	COG0436	Aminotransferase
CXR48_RS04760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR48_RS04765	COG1253	flavin adenine dinucleotide binding
CXR48_RS04770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR48_RS04775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR48_RS04780	COG0584	glycerophosphoryl diester phosphodiesterase
CXR48_RS04790	COG0668	transmembrane transport
CXR48_RS04795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXR48_RS04800	COG0726	polysaccharide deacetylase
CXR48_RS04805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS04810	COG3226	Transcriptional regulator
CXR48_RS04820	COG0589	response to stress
CXR48_RS04825	COG1132	(ABC) transporter
CXR48_RS04830	COG1132	(ABC) transporter
CXR48_RS04835	COG0702	epimerase
CXR48_RS04855	COG0189	ligase activity
CXR48_RS04860	COG0189	ligase activity
CXR48_RS04875	COG4335	DNA alkylation repair
CXR48_RS04880	COG0561	phosphatase activity
CXR48_RS04885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXR48_RS04895	COG0475	glutathione-regulated potassium exporter activity
CXR48_RS04900	COG0490	domain, Protein
CXR48_RS04910	COG1024	Enoyl-CoA hydratase
CXR48_RS04920	COG4152	abc transporter atp-binding protein
CXR48_RS04925	COG1668	transmembrane transport
CXR48_RS04930	COG0420	3'-5' exonuclease activity
CXR48_RS04935	COG4717	serine-type aminopeptidase activity
CXR48_RS04950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXR48_RS04990	COG4980	gas vesicle protein
CXR48_RS05005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXR48_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
CXR48_RS05015	COG1131	(ABC) transporter
CXR48_RS05020	COG4473	ABC transporter
CXR48_RS05030	COG1473	amidohydrolase
CXR48_RS05035	COG3069	C4-dicarboxylate transmembrane transporter activity
CXR48_RS05040	COG2329	Antibiotic biosynthesis monooxygenase
CXR48_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR48_RS05055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXR48_RS05060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CXR48_RS05065	COG1309	transcriptional regulator
CXR48_RS05070	COG1511	domain protein
CXR48_RS05075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR48_RS05085	COG1363	Peptidase, m42
CXR48_RS05090	COG1301	dicarboxylic acid transport
CXR48_RS05100	COG1234	tRNA 3'-trailer cleavage
CXR48_RS05105	COG0095	Lipoate-protein ligase
CXR48_RS05110	COG0702	epimerase
CXR48_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS05125	COG0501	Belongs to the peptidase M48B family
CXR48_RS05130	COG1404	Belongs to the peptidase S8 family
CXR48_RS05140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CXR48_RS05145	COG0406	alpha-ribazole phosphatase activity
CXR48_RS05150	COG0183	Belongs to the thiolase family
CXR48_RS05155	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS05160	COG1268	BioY protein
CXR48_RS05165	COG0840	transmembrane signaling receptor activity
CXR48_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR48_RS05170	COG0723	plastoquinol--plastocyanin reductase activity
CXR48_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS05185	COG4903	ComK protein
CXR48_RS05195	COG5646	InterPro IPR014922
CXR48_RS05215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR48_RS05230	COG0398	Pfam SNARE associated Golgi protein
CXR48_RS05235	COG0681	Belongs to the peptidase S26 family
CXR48_RS05240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR48_RS05245	COG1846	Transcriptional regulator
CXR48_RS05250	COG3180	Ammonia monooxygenase
CXR48_RS05255	COG2814	Major facilitator Superfamily
CXR48_RS05265	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CXR48_RS05270	COG2323	membrane
CXR48_RS05285	COG0420	3'-5' exonuclease activity
CXR48_RS05290	COG0419	ATPase involved in DNA repair
CXR48_RS05295	COG1403	HNH endonuclease
CXR48_RS05335	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR48_RS05355	COG0367	asparagine synthase
CXR48_RS05360	COG1562	ergosterol biosynthetic process
CXR48_RS05365	COG0534	Mate efflux family protein
CXR48_RS05370	COG2207	Transcriptional regulator
CXR48_RS05370	COG1917	Cupin 2, conserved barrel domain protein
CXR48_RS05375	COG1609	Transcriptional regulator
CXR48_RS05380	COG0673	inositol 2-dehydrogenase activity
CXR48_RS05385	COG2318	DinB family
CXR48_RS05395	COG1357	PFAM Pentapeptide repeats (8 copies)
CXR48_RS05400	COG2153	protein acetylation
CXR48_RS05405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CXR48_RS05405	COG0646	methionine synthase
CXR48_RS05415	COG2996	Protein conserved in bacteria
CXR48_RS05420	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR48_RS05435	COG1307	EDD domain protein, DegV family
CXR48_RS05440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS05455	COG0561	phosphatase activity
CXR48_RS05460	COG1073	alpha beta
CXR48_RS05465	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR48_RS05475	COG0277	FAD linked oxidase domain protein
CXR48_RS05480	COG2271	Major facilitator Superfamily
CXR48_RS05490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXR48_RS05500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR48_RS05505	COG0505	Belongs to the CarA family
CXR48_RS05510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXR48_RS05515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXR48_RS05535	COG2267	carboxylic ester hydrolase activity
CXR48_RS05545	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR48_RS05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR48_RS05565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR48_RS05570	COG5504	Zn-dependent protease
CXR48_RS05575	COG0444	Belongs to the ABC transporter superfamily
CXR48_RS05580	COG4608	Belongs to the ABC transporter superfamily
CXR48_RS05590	COG0601	transmembrane transport
CXR48_RS05595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR48_RS05605	COG0180	Tryptophanyl-tRNA synthetase
CXR48_RS05610	COG4166	transmembrane transport
CXR48_RS05615	COG0601	transmembrane transport
CXR48_RS05630	COG4608	Belongs to the ABC transporter superfamily
CXR48_RS05640	COG0456	acetyltransferase
CXR48_RS05645	COG1393	Belongs to the ArsC family
CXR48_RS05650	COG0861	Integral membrane protein TerC family
CXR48_RS05655	COG4862	establishment of competence for transformation
CXR48_RS05660	COG4469	Competence protein
CXR48_RS05665	COG1164	Oligoendopeptidase f
CXR48_RS05670	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR48_RS05675	COG2346	COG2346, Truncated hemoglobins
CXR48_RS05680	COG0741	lytic transglycosylase activity
CXR48_RS05685	COG4116	CYTH
CXR48_RS05695	COG2357	RelA SpoT domain protein
CXR48_RS05700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR48_RS05705	COG0564	pseudouridine synthase activity
CXR48_RS05720	COG0569	domain protein
CXR48_RS05720	COG0475	glutathione-regulated potassium exporter activity
CXR48_RS05725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CXR48_RS05730	COG0352	thiamine-phosphate diphosphorylase activity
CXR48_RS05735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR48_RS05740	COG2104	thiamine diphosphate biosynthetic process
CXR48_RS05750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXR48_RS05755	COG0351	phosphomethylpyrimidine kinase
CXR48_RS05760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXR48_RS05815	COG0210	DNA helicase
CXR48_RS05835	COG1131	(ABC) transporter
CXR48_RS05845	COG2153	protein acetylation
CXR48_RS05855	COG2382	esterase
CXR48_RS05860	COG0626	cystathionine gamma-synthase activity
CXR48_RS05865	COG0626	cystathionine gamma-synthase activity
CXR48_RS05895	COG5444	nuclease activity
CXR48_RS05905	COG0346	lactoylglutathione lyase activity
CXR48_RS05910	COG2367	Beta-lactamase
CXR48_RS05915	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CXR48_RS05925	COG1846	Transcriptional regulator
CXR48_RS05935	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CXR48_RS05940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXR48_RS05945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CXR48_RS05950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS05950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS05955	COG1447	Phosphotransferase system cellobiose-specific component IIA
CXR48_RS05965	COG1349	DNA-binding transcription factor activity
CXR48_RS05990	COG1285	pathogenesis
CXR48_RS06005	COG2205	protein histidine kinase activity
CXR48_RS06015	COG3383	formate dehydrogenase (NAD+) activity
CXR48_RS06020	COG2427	Protein of unknown function (DUF1641)
CXR48_RS06025	COG2124	cytochrome p450
CXR48_RS06030	COG1819	glycosyl
CXR48_RS06040	COG1587	Uroporphyrinogen-III synthase
CXR48_RS06045	COG0390	transport system, permease component
CXR48_RS06050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR48_RS06055	COG0697	spore germination
CXR48_RS06060	COG4297	protein containing double-stranded beta helix domain
CXR48_RS06070	COG1252	NADH dehydrogenase
CXR48_RS06080	COG2211	Major facilitator Superfamily
CXR48_RS06085	COG1609	Transcriptional regulator
CXR48_RS06090	COG0246	Mannitol dehydrogenase
CXR48_RS06095	COG2721	sulfolactate sulfo-lyase activity
CXR48_RS06100	COG0745	RESPONSE REGULATOR receiver
CXR48_RS06105	COG2205	protein histidine kinase activity
CXR48_RS06105	COG2770	Histidine kinase
CXR48_RS06125	COG4585	Histidine kinase
CXR48_RS06130	COG2197	response regulator
CXR48_RS06155	COG0730	response to heat
CXR48_RS06160	COG2318	DinB family
CXR48_RS06165	COG0457	Tetratricopeptide repeat
CXR48_RS06170	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS06170	COG1388	LysM domain
CXR48_RS06170	COG5632	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS06180	COG4195	phage-related replication protein
CXR48_RS06185	COG2856	Zn peptidase
CXR48_RS06195	COG1396	sequence-specific DNA binding
CXR48_RS06205	COG1522	sequence-specific DNA binding
CXR48_RS06210	COG1484	DNA-dependent DNA replication
CXR48_RS06225	COG1595	DNA-templated transcription, initiation
CXR48_RS06230	COG5484	DNA packaging
CXR48_RS06230	COG3728	DNA packaging
CXR48_RS06235	COG1783	phage Terminase large subunit
CXR48_RS06240	COG5518	Phage portal protein
CXR48_RS06245	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CXR48_RS06250	COG4653	Phage capsid family
CXR48_RS06300	COG3953	SLT domain
CXR48_RS06300	COG3953	SLT domain
CXR48_RS06300	COG5412	phage tail tape measure protein
CXR48_RS06300	COG5412	phage tail tape measure protein
CXR48_RS06300	COG3953	SLT domain
CXR48_RS06300	COG5412	phage tail tape measure protein
CXR48_RS06305	COG1652	LysM domain
CXR48_RS06310	COG4193	domain, Protein
CXR48_RS06320	COG3628	GPW Gp25 family protein
CXR48_RS06325	COG3299	homolog of phage Mu protein gp47
CXR48_RS06330	COG3778	Protein conserved in bacteria
CXR48_RS06370	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS06370	COG5632	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS06385	COG0306	phosphate transporter
CXR48_RS06390	COG1392	Phosphate transport regulator
CXR48_RS06395	COG0531	amino acid
CXR48_RS06400	COG0346	lactoylglutathione lyase activity
CXR48_RS06405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXR48_RS06410	COG0463	Glycosyl transferase, family 2
CXR48_RS06415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR48_RS06420	COG0477	Major facilitator Superfamily
CXR48_RS06425	COG2362	D-Aminopeptidase
CXR48_RS06430	COG0601	transmembrane transport
CXR48_RS06435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR48_RS06440	COG0444	Belongs to the ABC transporter superfamily
CXR48_RS06445	COG4166	transmembrane transport
CXR48_RS06450	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXR48_RS06455	COG4948	Mandelate Racemase Muconate Lactonizing
CXR48_RS06460	COG0791	NLP P60 protein
CXR48_RS06465	COG4608	Belongs to the ABC transporter superfamily
CXR48_RS06470	COG2706	6-phosphogluconolactonase activity
CXR48_RS06475	COG1834	amidinotransferase
CXR48_RS06480	COG1607	acyl-coa hydrolase
CXR48_RS06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR48_RS06490	COG2076	Multidrug Resistance protein
CXR48_RS06495	COG2076	Multidrug Resistance protein
CXR48_RS06500	COG0788	formyltetrahydrofolate deformylase activity
CXR48_RS06505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXR48_RS06515	COG1764	response to oxidative stress
CXR48_RS06520	COG1846	Transcriptional regulator
CXR48_RS06525	COG1764	response to oxidative stress
CXR48_RS06540	COG0463	Glycosyl transferase, family 2
CXR48_RS06540	COG0457	Tetratricopeptide repeat
CXR48_RS06550	COG2814	Major facilitator Superfamily
CXR48_RS06555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR48_RS06565	COG1404	Belongs to the peptidase S8 family
CXR48_RS06570	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS06575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CXR48_RS06580	COG1122	ATPase activity
CXR48_RS06585	COG4721	ABC-type cobalt transport system, permease component
CXR48_RS06590	COG3858	chitin binding
CXR48_RS06590	COG1388	LysM domain
CXR48_RS06605	COG2239	Acts as a magnesium transporter
CXR48_RS06610	COG0789	Transcriptional regulator
CXR48_RS06625	COG1846	Transcriptional regulator
CXR48_RS06630	COG0726	polysaccharide deacetylase
CXR48_RS06635	COG1793	dna ligase
CXR48_RS06635	COG3285	dna ligase
CXR48_RS06640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CXR48_RS06650	COG0586	Pfam SNARE associated Golgi protein
CXR48_RS06655	COG0861	Integral membrane protein TerC family
CXR48_RS06660	COG1191	sigma factor activity
CXR48_RS06685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR48_RS06690	COG2323	membrane
CXR48_RS06700	COG3594	Acyltransferase
CXR48_RS06705	COG5002	protein histidine kinase activity
CXR48_RS06710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR48_RS06725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR48_RS06730	COG0436	Aminotransferase
CXR48_RS06760	COG3852	Histidine kinase
CXR48_RS06765	COG1846	Transcriptional regulator
CXR48_RS06770	COG1360	Flagellar Motor Protein
CXR48_RS06775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CXR48_RS06780	COG0542	response to heat
CXR48_RS06790	COG3949	Membrane
CXR48_RS06805	COG0720	synthase
CXR48_RS06810	COG0602	queuosine metabolic process
CXR48_RS06825	COG4873	Protein conserved in bacteria
CXR48_RS06835	COG3773	Cell wall hydrolase
CXR48_RS06840	COG2244	polysaccharide biosynthetic process
CXR48_RS06845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS06850	COG2217	Heavy metal translocating P-type atpase
CXR48_RS06855	COG0006	proline dipeptidase activity
CXR48_RS06860	COG1609	Transcriptional regulator
CXR48_RS06865	COG3711	transcriptional antiterminator
CXR48_RS06870	COG2190	(PTS) system
CXR48_RS06870	COG1263	PTS System
CXR48_RS06870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS06875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS06880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXR48_RS06890	COG1533	DNA photolyase activity
CXR48_RS06895	COG0840	transmembrane signaling receptor activity
CXR48_RS06900	COG2084	Dehydrogenase
CXR48_RS06905	COG2340	Cysteine-rich secretory protein family
CXR48_RS06910	COG0768	penicillin binding
CXR48_RS06915	COG4191	Histidine kinase
CXR48_RS06920	COG0436	Aminotransferase
CXR48_RS06930	COG0784	Response regulator, receiver
CXR48_RS06930	COG0835	chemotaxis
CXR48_RS06940	COG2814	Major facilitator Superfamily
CXR48_RS06945	COG1376	ErfK ybiS ycfS ynhG family protein
CXR48_RS06950	COG1408	metallophosphoesterase
CXR48_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS06970	COG2200	EAL domain
CXR48_RS06975	COG4703	Protein of unknown function (DUF1797)
CXR48_RS06980	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CXR48_RS06990	COG0517	IMP dehydrogenase activity
CXR48_RS06995	COG0583	DNA-binding transcription factor activity
CXR48_RS07000	COG0716	FMN binding
CXR48_RS07010	COG0716	FMN binding
CXR48_RS07030	COG0668	transmembrane transport
CXR48_RS07035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS07055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXR48_RS07060	COG0303	'Molybdopterin
CXR48_RS07065	COG1763	Mo-molybdopterin cofactor biosynthetic process
CXR48_RS07070	COG0314	molybdopterin synthase activity
CXR48_RS07075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CXR48_RS07085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXR48_RS07090	COG1136	(ABC) transporter
CXR48_RS07095	COG0577	efflux transmembrane transporter activity
CXR48_RS07100	COG1349	DNA-binding transcription factor activity
CXR48_RS07105	COG1105	Belongs to the carbohydrate kinase PfkB family
CXR48_RS07110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS07110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXR48_RS07110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXR48_RS07115	COG0681	Belongs to the peptidase S26 family
CXR48_RS07125	COG0488	(ABC) transporter
CXR48_RS07130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXR48_RS07135	COG2309	aminopeptidase activity
CXR48_RS07145	COG1077	Cell shape determining protein MreB Mrl
CXR48_RS07155	COG2002	toxin-antitoxin pair type II binding
CXR48_RS07160	COG3852	Histidine kinase
CXR48_RS07165	COG2105	PFAM AIG2 family protein
CXR48_RS07165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CXR48_RS07170	COG0569	domain protein
CXR48_RS07180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR48_RS07195	COG0561	phosphatase activity
CXR48_RS07200	COG0242	peptide deformylase activity
CXR48_RS07210	COG0497	DNA recombination
CXR48_RS07225	COG4221	oxidoreductase activity
CXR48_RS07225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS07225	COG3321	synthase
CXR48_RS07230	COG3321	synthase
CXR48_RS07230	COG0300	oxidoreductase activity
CXR48_RS07230	COG4221	oxidoreductase activity
CXR48_RS07230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS07235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS07235	COG3321	synthase
CXR48_RS07235	COG4221	oxidoreductase activity
CXR48_RS07240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS07240	COG3321	synthase
CXR48_RS07240	COG0300	oxidoreductase activity
CXR48_RS07240	COG4221	oxidoreductase activity
CXR48_RS07245	COG0300	oxidoreductase activity
CXR48_RS07245	COG3321	synthase
CXR48_RS07245	COG4221	oxidoreductase activity
CXR48_RS07245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS07250	COG4221	oxidoreductase activity
CXR48_RS07250	COG0300	oxidoreductase activity
CXR48_RS07250	COG3321	synthase
CXR48_RS07250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS07255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS07255	COG3321	synthase
CXR48_RS07255	COG4221	oxidoreductase activity
CXR48_RS07260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR48_RS07265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXR48_RS07270	COG0022	dehydrogenase e1 component
CXR48_RS07275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR48_RS07280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR48_RS07285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS07300	COG1982	Orn Lys Arg decarboxylase major
CXR48_RS07325	COG0483	inositol monophosphate 1-phosphatase activity
CXR48_RS07335	COG3227	Zinc metalloprotease (Elastase)
CXR48_RS07360	COG1217	gtp-binding protein TYPA
CXR48_RS07370	COG4896	Protein conserved in bacteria
CXR48_RS07380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXR48_RS07385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXR48_RS07390	COG2066	Belongs to the glutaminase family
CXR48_RS07400	COG0772	Belongs to the SEDS family
CXR48_RS07405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CXR48_RS07420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXR48_RS07420	COG2010	Cytochrome c
CXR48_RS07425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR48_RS07430	COG1845	cytochrome c oxidase, subunit III
CXR48_RS07435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXR48_RS07440	COG3336	cytochrome c oxidase
CXR48_RS07450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CXR48_RS07455	COG2340	Cysteine-rich secretory protein family
CXR48_RS07470	COG3679	Belongs to the UPF0342 family
CXR48_RS07485	COG0742	ribosomal rna small subunit methyltransferase
CXR48_RS07495	COG3314	Sporulation integral membrane protein YlbJ
CXR48_RS07500	COG1752	Esterase of the alpha-beta hydrolase superfamily
CXR48_RS07505	COG3480	Lon protease (S16) C-terminal proteolytic domain
CXR48_RS07515	COG1399	metal-binding, possibly nucleic acid-binding protein
CXR48_RS07535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXR48_RS07555	COG4839	cell division protein FtsL
CXR48_RS07560	COG0768	penicillin binding
CXR48_RS07565	COG0768	penicillin binding
CXR48_RS07585	COG0772	Belongs to the SEDS family
CXR48_RS07600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXR48_RS07605	COG0849	cell division
CXR48_RS07610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXR48_RS07615	COG4412	M6 family metalloprotease domain protein
CXR48_RS07615	COG1404	Belongs to the peptidase S8 family
CXR48_RS07625	COG1191	sigma factor activity
CXR48_RS07630	COG1191	sigma factor activity
CXR48_RS07635	COG1119	ATPase activity
CXR48_RS07640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR48_RS07645	COG1873	PFAM PRC-barrel domain
CXR48_RS07650	COG1496	oxidoreductase activity
CXR48_RS07655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXR48_RS07665	COG0762	integral membrane protein
CXR48_RS07670	COG2302	S4 RNA-binding domain
CXR48_RS07675	COG3599	regulation of cell shape
CXR48_RS07685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXR48_RS07690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXR48_RS07700	COG0564	pseudouridine synthase activity
CXR48_RS07710	COG2233	PERMEase
CXR48_RS07720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR48_RS07725	COG0505	Belongs to the CarA family
CXR48_RS07730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXR48_RS07745	COG0284	orotidine-5'-phosphate decarboxylase activity
CXR48_RS07750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXR48_RS07760	COG0306	phosphate transporter
CXR48_RS07775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR48_RS07780	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CXR48_RS07785	COG1648	precorrin-2 dehydrogenase activity
CXR48_RS07800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CXR48_RS07805	COG1561	YicC-like family, N-terminal region
CXR48_RS07815	COG0194	GDP metabolic process
CXR48_RS07825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXR48_RS07830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXR48_RS07835	COG0242	peptide deformylase activity
CXR48_RS07845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXR48_RS07845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXR48_RS07855	COG0631	protein serine/threonine phosphatase activity
CXR48_RS07860	COG0515	serine threonine protein kinase
CXR48_RS07860	COG2815	serine threonine protein kinase
CXR48_RS07870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXR48_RS07875	COG1564	THIamine pyrophosphokinase
CXR48_RS07890	COG1302	Protein conserved in bacteria
CXR48_RS07895	COG1461	Dihydroxyacetone kinase
CXR48_RS07900	COG1760	l-serine dehydratase
CXR48_RS07905	COG1760	l-serine dehydratase
CXR48_RS07910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXR48_RS07925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CXR48_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS07945	COG1196	nuclear chromosome segregation
CXR48_RS07950	COG0552	protein localization to endoplasmic reticulum
CXR48_RS07965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXR48_RS07975	COG1837	Belongs to the UPF0109 family
CXR48_RS08000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CXR48_RS08015	COG2257	FlhB HrpN YscU SpaS Family
CXR48_RS08025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXR48_RS08030	COG0758	DNA mediated transformation
CXR48_RS08035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXR48_RS08045	COG4974	Belongs to the 'phage' integrase family
CXR48_RS08065	COG1815	bacterial-type flagellum-dependent cell motility
CXR48_RS08070	COG1558	bacterial-type flagellum-dependent cell motility
CXR48_RS08075	COG1677	Flagellar hook-basal body complex protein FliE
CXR48_RS08080	COG1766	The M ring may be actively involved in energy transduction
CXR48_RS08085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXR48_RS08090	COG1317	bacterial-type flagellum organization
CXR48_RS08095	COG1157	protein secretion by the type III secretion system
CXR48_RS08100	COG2882	bacterial-type flagellum organization
CXR48_RS08105	COG3334	PFAM MgtE intracellular
CXR48_RS08110	COG3144	bacterial-type flagellum assembly
CXR48_RS08115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CXR48_RS08120	COG4786	Flagellar basal body rod
CXR48_RS08125	COG1582	Flagellar protein (FlbD)
CXR48_RS08130	COG1580	Controls the rotational direction of flagella during chemotaxis
CXR48_RS08135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXR48_RS08140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CXR48_RS08140	COG1776	CheC inhibitor of MCP methylation
CXR48_RS08145	COG2201	protein-glutamate methylesterase activity
CXR48_RS08150	COG3190	flagellar
CXR48_RS08155	COG1338	Plays a role in the flagellum-specific transport system
CXR48_RS08160	COG1987	bacterial-type flagellum assembly
CXR48_RS08165	COG1684	flagellar biosynthetic protein fliR
CXR48_RS08170	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXR48_RS08175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXR48_RS08180	COG1419	protein localization to endoplasmic reticulum
CXR48_RS08185	COG0455	bacterial-type flagellum organization
CXR48_RS08190	COG2201	protein-glutamate methylesterase activity
CXR48_RS08195	COG2198	Histidine kinase
CXR48_RS08195	COG0643	Histidine kinase
CXR48_RS08200	COG0835	chemotaxis
CXR48_RS08205	COG1776	CheC inhibitor of MCP methylation
CXR48_RS08215	COG1191	sigma factor activity
CXR48_RS08245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR48_RS08250	COG4589	Belongs to the CDS family
CXR48_RS08260	COG0750	zinc metalloprotease
CXR48_RS08270	COG2176	DNA-directed DNA polymerase activity
CXR48_RS08280	COG0195	Participates in both transcription termination and antitermination
CXR48_RS08285	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CXR48_RS08290	COG1358	cellular component organization or biogenesis
CXR48_RS08300	COG1550	Protein conserved in bacteria
CXR48_RS08315	COG0196	riboflavin kinase activity
CXR48_RS08330	COG0726	polysaccharide deacetylase
CXR48_RS08335	COG0612	Peptidase, M16
CXR48_RS08340	COG1873	PFAM PRC-barrel domain
CXR48_RS08345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXR48_RS08350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXR48_RS08355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXR48_RS08360	COG0527	aspartate kinase activity
CXR48_RS08370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR48_RS08375	COG0740	serine-type endopeptidase activity
CXR48_RS08385	COG1674	ftsk spoiiie
CXR48_RS08385	COG4980	gas vesicle protein
CXR48_RS08390	COG2188	Transcriptional regulator
CXR48_RS08395	COG2814	Major facilitator Superfamily
CXR48_RS08400	COG1846	Transcriptional regulator
CXR48_RS08405	COG2409	Drug exporters of the RND superfamily
CXR48_RS08405	COG1033	growth of symbiont in host cell
CXR48_RS08410	COG0612	Peptidase, M16
CXR48_RS08415	COG0612	Peptidase, M16
CXR48_RS08420	COG0300	oxidoreductase activity
CXR48_RS08435	COG1426	Protein conserved in bacteria
CXR48_RS08440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXR48_RS08455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR48_RS08465	COG1692	metallophosphoesterase
CXR48_RS08470	COG2359	stage V sporulation protein S
CXR48_RS08490	COG4550	Control of competence regulator ComK, YlbF/YmcA
CXR48_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS08545	COG3425	synthase
CXR48_RS08550	COG1024	Enoyl-CoA hydratase
CXR48_RS08555	COG1024	Enoyl-CoA hydratase
CXR48_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS08560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS08560	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS08560	COG0300	oxidoreductase activity
CXR48_RS08560	COG3321	synthase
CXR48_RS08565	COG3321	synthase
CXR48_RS08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS08565	COG0300	oxidoreductase activity
CXR48_RS08565	COG4221	oxidoreductase activity
CXR48_RS08570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS08570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS08570	COG3321	synthase
CXR48_RS08570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS08570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS08570	COG3321	synthase
CXR48_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS08575	COG3321	synthase
CXR48_RS08575	COG4221	oxidoreductase activity
CXR48_RS08580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS08580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXR48_RS08580	COG3321	synthase
CXR48_RS08580	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CXR48_RS08585	COG2124	cytochrome p450
CXR48_RS08590	COG3209	COG3209 Rhs family protein
CXR48_RS08595	COG3619	membrane
CXR48_RS08605	COG1404	Belongs to the peptidase S8 family
CXR48_RS08615	COG4195	phage-related replication protein
CXR48_RS08620	COG1764	response to oxidative stress
CXR48_RS08630	COG2076	Multidrug Resistance protein
CXR48_RS08670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR48_RS08675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR48_RS08685	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS08695	COG0464	growth
CXR48_RS08700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXR48_RS08705	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CXR48_RS08710	COG0789	Transcriptional regulator
CXR48_RS08715	COG0174	glutamine synthetase
CXR48_RS08725	COG2211	Major facilitator Superfamily
CXR48_RS08730	COG3507	Belongs to the glycosyl hydrolase 43 family
CXR48_RS08745	COG1070	Carbohydrate kinase
CXR48_RS08750	COG0574	Belongs to the PEP-utilizing enzyme family
CXR48_RS08750	COG3848	Pyruvate phosphate dikinase
CXR48_RS08775	COG1064	alcohol dehydrogenase
CXR48_RS08795	COG0456	acetyltransferase
CXR48_RS08815	COG3397	chitin binding
CXR48_RS08830	COG5434	Belongs to the glycosyl hydrolase 28 family
CXR48_RS08840	COG0756	dUTP diphosphatase activity
CXR48_RS08845	COG4195	phage-related replication protein
CXR48_RS08875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CXR48_RS08885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXR48_RS08905	COG0785	Cytochrome C biogenesis protein
CXR48_RS08910	COG2201	protein-glutamate methylesterase activity
CXR48_RS08915	COG4846	Membrane protein involved in cytochrome C biogenesis
CXR48_RS08925	COG0071	Belongs to the small heat shock protein (HSP20) family
CXR48_RS08940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXR48_RS08945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS08965	COG0824	Thioesterase
CXR48_RS08975	COG4841	protein insertion into membrane
CXR48_RS08985	COG1832	CoA-binding protein
CXR48_RS08990	COG0187	DNA topoisomerase II activity
CXR48_RS08995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR48_RS09005	COG1115	amino acid carrier protein
CXR48_RS09015	COG1063	alcohol dehydrogenase
CXR48_RS09020	COG0800	Aldolase
CXR48_RS09025	COG1312	Catalyzes the dehydration of D-mannonate
CXR48_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS09035	COG1609	Transcriptional regulator
CXR48_RS09040	COG2271	Major facilitator Superfamily
CXR48_RS09075	COG2205	protein histidine kinase activity
CXR48_RS09080	COG0745	RESPONSE REGULATOR receiver
CXR48_RS09090	COG3507	Belongs to the glycosyl hydrolase 43 family
CXR48_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS09125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXR48_RS09130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CXR48_RS09135	COG2610	gluconate transmembrane transporter activity
CXR48_RS09140	COG2124	cytochrome p450
CXR48_RS09160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR48_RS09170	COG2246	polysaccharide biosynthetic process
CXR48_RS09175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CXR48_RS09180	COG0586	Pfam SNARE associated Golgi protein
CXR48_RS09185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR48_RS09190	COG1024	Enoyl-CoA hydratase
CXR48_RS09195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR48_RS09200	COG0511	ligase activity, forming carbon-carbon bonds
CXR48_RS09205	COG0439	Biotin carboxylase
CXR48_RS09210	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS09215	COG1960	acyl-CoA dehydrogenase activity
CXR48_RS09220	COG1649	PFAM Uncharacterised BCR, COG1649
CXR48_RS09230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS09230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CXR48_RS09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS09240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS09260	COG2027	D-alanyl-D-alanine carboxypeptidase
CXR48_RS09265	COG2017	converts alpha-aldose to the beta-anomer
CXR48_RS09270	COG0534	Mate efflux family protein
CXR48_RS09285	COG0582	viral genome integration into host DNA
CXR48_RS09290	COG0166	Belongs to the GPI family
CXR48_RS09295	COG0405	Gamma-glutamyltransferase
CXR48_RS09300	COG2814	Major facilitator Superfamily
CXR48_RS09305	COG0640	Transcriptional regulator
CXR48_RS09320	COG0604	alcohol dehydrogenase
CXR48_RS09325	COG0493	'glutamate synthase
CXR48_RS09330	COG0069	glutamate synthase activity
CXR48_RS09330	COG0067	glutamate synthase
CXR48_RS09330	COG0070	glutamate synthase
CXR48_RS09335	COG0583	DNA-binding transcription factor activity
CXR48_RS09340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXR48_RS09355	COG0300	oxidoreductase activity
CXR48_RS09360	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CXR48_RS09370	COG2814	Major facilitator Superfamily
CXR48_RS09375	COG1070	Carbohydrate kinase
CXR48_RS09380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR48_RS09385	COG0243	molybdopterin cofactor binding
CXR48_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS09415	COG1733	regulation of RNA biosynthetic process
CXR48_RS09420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR48_RS09425	COG2207	Transcriptional regulator
CXR48_RS09425	COG0662	Cupin 2, conserved barrel domain protein
CXR48_RS09430	COG1309	transcriptional regulator
CXR48_RS09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS09445	COG0640	Transcriptional regulator
CXR48_RS09450	COG0741	lytic transglycosylase activity
CXR48_RS09455	COG2322	membrane
CXR48_RS09470	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXR48_RS09480	COG3584	3D domain protein
CXR48_RS09480	COG1388	LysM domain
CXR48_RS09485	COG0514	ATP-dependent DNA helicase (RecQ)
CXR48_RS09495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CXR48_RS09500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXR48_RS09515	COG0071	Belongs to the small heat shock protein (HSP20) family
CXR48_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS09550	COG1657	PFAM Prenyltransferase squalene oxidase
CXR48_RS09555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXR48_RS09560	COG0733	neurotransmitter:sodium symporter activity
CXR48_RS09565	COG0385	Bile acid
CXR48_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR48_RS09585	COG4548	von Willebrand factor, type A
CXR48_RS09590	COG0714	Associated with various cellular activities
CXR48_RS09595	COG2032	superoxide dismutase activity
CXR48_RS09600	COG1388	LysM domain
CXR48_RS09600	COG0791	NLP P60 protein
CXR48_RS09605	COG1819	glycosyl
CXR48_RS09610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CXR48_RS09615	COG0534	Mate efflux family protein
CXR48_RS09620	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS09625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR48_RS09630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR48_RS09640	COG2962	Rard protein
CXR48_RS09655	COG1942	4-Oxalocrotonate Tautomerase
CXR48_RS09665	COG1733	regulation of RNA biosynthetic process
CXR48_RS09670	COG0778	Nitroreductase
CXR48_RS09675	COG0400	carboxylic ester hydrolase activity
CXR48_RS09680	COG0346	lactoylglutathione lyase activity
CXR48_RS09690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR48_RS09700	COG2723	6-phospho-beta-galactosidase activity
CXR48_RS09705	COG2188	Transcriptional regulator
CXR48_RS09710	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS09710	COG0793	Belongs to the peptidase S41A family
CXR48_RS09715	COG2226	methyltransferase
CXR48_RS09725	COG1876	peptidase activity
CXR48_RS09745	COG0671	phosphoesterase, PA-phosphatase related
CXR48_RS09780	COG1509	lysine 2,3-aminomutase activity
CXR48_RS09785	COG0456	acetyltransferase
CXR48_RS09790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR48_RS09795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXR48_RS09800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CXR48_RS09805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR48_RS09810	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CXR48_RS09820	COG0456	acetyltransferase
CXR48_RS09825	COG0463	Glycosyl transferase, family 2
CXR48_RS09840	COG4641	Protein conserved in bacteria
CXR48_RS09850	COG1086	Polysaccharide biosynthesis protein
CXR48_RS09890	COG1793	dna ligase
CXR48_RS09905	COG1388	LysM domain
CXR48_RS09910	COG0457	Tetratricopeptide repeat
CXR48_RS09920	COG3391	amine dehydrogenase activity
CXR48_RS09955	COG5444	nuclease activity
CXR48_RS09970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CXR48_RS09990	COG1846	Transcriptional regulator
CXR48_RS09995	COG4698	Protein conserved in bacteria
CXR48_RS10000	COG2755	lipolytic protein G-D-S-L family
CXR48_RS10005	COG1999	signal sequence binding
CXR48_RS10015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXR48_RS10020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CXR48_RS10025	COG1272	protein, Hemolysin III
CXR48_RS10030	COG0204	Acyl-transferase
CXR48_RS10035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CXR48_RS10050	COG2521	methyltransferase
CXR48_RS10050	COG2136	Putative SAM-dependent methyltransferase
CXR48_RS10065	COG1413	lyase activity
CXR48_RS10070	COG1418	mRNA catabolic process
CXR48_RS10075	COG0386	Belongs to the glutathione peroxidase family
CXR48_RS10085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXR48_RS10090	COG1278	Cold shock
CXR48_RS10110	COG0328	RNA-DNA hybrid ribonuclease activity
CXR48_RS10115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXR48_RS10120	COG0328	RNA-DNA hybrid ribonuclease activity
CXR48_RS10130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR48_RS10145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CXR48_RS10155	COG1755	Isoprenylcysteine carboxyl methyltransferase
CXR48_RS10160	COG3424	synthase
CXR48_RS10185	COG1335	isochorismatase
CXR48_RS10225	COG4824	toxin secretion phage lysis holin
CXR48_RS10245	COG5434	Belongs to the glycosyl hydrolase 28 family
CXR48_RS10250	COG1705	Flagellar rod assembly protein muramidase FlgJ
CXR48_RS10260	COG3953	SLT domain
CXR48_RS10260	COG5280	Phage tail tape measure protein TP901
CXR48_RS10360	COG1595	DNA-templated transcription, initiation
CXR48_RS10385	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CXR48_RS10390	COG1484	DNA-dependent DNA replication
CXR48_RS10395	COG3935	DnaD domain protein
CXR48_RS10435	COG3646	Phage regulatory protein
CXR48_RS10435	COG3645	SOS response
CXR48_RS10450	COG3620	sequence-specific DNA binding
CXR48_RS10455	COG0582	viral genome integration into host DNA
CXR48_RS10460	COG2233	PERMEase
CXR48_RS10470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CXR48_RS10475	COG1199	ATP-dependent helicase activity
CXR48_RS10490	COG0116	Belongs to the methyltransferase superfamily
CXR48_RS10515	COG3359	exonuclease
CXR48_RS10520	COG1111	helicase
CXR48_RS10520	COG1205	dead DEAH box helicase
CXR48_RS10525	COG2190	(PTS) system
CXR48_RS10530	COG0071	Belongs to the small heat shock protein (HSP20) family
CXR48_RS10570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR48_RS10570	COG4499	WXG100 protein secretion system (Wss), protein YukC
CXR48_RS10580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXR48_RS10585	COG3935	DnaD domain protein
CXR48_RS10595	COG0436	Aminotransferase
CXR48_RS10600	COG5353	protein conserved in bacteria
CXR48_RS10610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXR48_RS10610	COG1199	ATP-dependent helicase activity
CXR48_RS10640	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS10645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR48_RS10660	COG1694	Mazg nucleotide pyrophosphohydrolase
CXR48_RS10665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS10670	COG2140	Oxalate decarboxylase
CXR48_RS10680	COG4347	Protein of unknown function (DUF1405)
CXR48_RS10685	COG2010	Cytochrome c
CXR48_RS10685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR48_RS10690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR48_RS10695	COG0723	plastoquinol--plastocyanin reductase activity
CXR48_RS10710	COG0457	Tetratricopeptide repeat
CXR48_RS10720	COG0287	Prephenate dehydrogenase
CXR48_RS10755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CXR48_RS10760	COG4401	Chorismate mutase type I
CXR48_RS10775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CXR48_RS10780	COG0105	UTP biosynthetic process
CXR48_RS10785	COG0142	geranyltranstransferase activity
CXR48_RS10795	COG0142	geranyltranstransferase activity
CXR48_RS10810	COG0776	regulation of translation
CXR48_RS10815	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CXR48_RS10855	COG0539	negative regulation of cytoplasmic translation
CXR48_RS10865	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXR48_RS10870	COG2959	enzyme of heme biosynthesis
CXR48_RS10875	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS10875	COG3773	Cell wall hydrolase
CXR48_RS10880	COG2339	peptidase activity
CXR48_RS10885	COG0492	ferredoxin-NADP+ reductase activity
CXR48_RS10890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR48_RS10895	COG4862	establishment of competence for transformation
CXR48_RS10900	COG1408	metallophosphoesterase
CXR48_RS10910	COG1388	LysM domain
CXR48_RS10915	COG1266	CAAX protease self-immunity
CXR48_RS10920	COG0514	ATP-dependent DNA helicase (RecQ)
CXR48_RS10925	COG4955	Helix-turn-helix domain
CXR48_RS10930	COG1141	Ferredoxin
CXR48_RS10935	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CXR48_RS10940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR48_RS10950	COG1595	DNA-templated transcription, initiation
CXR48_RS10955	COG5002	protein histidine kinase activity
CXR48_RS10960	COG0745	RESPONSE REGULATOR receiver
CXR48_RS10965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXR48_RS10970	COG1333	cytochrome c biogenesis protein
CXR48_RS10975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS10980	COG1187	pseudouridine synthase activity
CXR48_RS10985	COG0700	Nucleoside recognition
CXR48_RS10990	COG2715	membrane protein required for spore maturation
CXR48_RS10995	COG1686	Belongs to the peptidase S11 family
CXR48_RS11020	COG1547	Domain of unknown function (DUF309)
CXR48_RS11030	COG0456	acetyltransferase
CXR48_RS11045	COG0307	riboflavin synthase, alpha
CXR48_RS11050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXR48_RS11050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXR48_RS11060	COG0681	Belongs to the peptidase S26 family
CXR48_RS11070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXR48_RS11075	COG4086	secreted protein
CXR48_RS11080	COG0019	diaminopimelate decarboxylase activity
CXR48_RS11085	COG0697	spore germination
CXR48_RS11100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR48_RS11120	COG1191	sigma factor activity
CXR48_RS11130	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS11135	COG1686	Belongs to the peptidase S11 family
CXR48_RS11140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CXR48_RS11145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CXR48_RS11150	COG4974	Belongs to the 'phage' integrase family
CXR48_RS11160	COG0735	belongs to the Fur family
CXR48_RS11165	COG1300	Membrane
CXR48_RS11180	COG0281	malic enzyme
CXR48_RS11185	COG1757	Na H antiporter
CXR48_RS11190	COG1027	Aspartate ammonia-lyase
CXR48_RS11195	COG0252	asparaginase activity
CXR48_RS11200	COG1396	sequence-specific DNA binding
CXR48_RS11205	COG1379	DNA repair
CXR48_RS11210	COG0494	nUDIX hydrolase
CXR48_RS11220	COG0667	Aldo Keto reductase
CXR48_RS11240	COG4918	Iron-sulphur cluster biosynthesis
CXR48_RS11245	COG0456	acetyltransferase
CXR48_RS11245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CXR48_RS11250	COG2329	Antibiotic biosynthesis monooxygenase
CXR48_RS11255	COG0456	acetyltransferase
CXR48_RS11260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXR48_RS11275	COG0628	permease
CXR48_RS11285	COG0346	lactoylglutathione lyase activity
CXR48_RS11295	COG3048	D-serine ammonia-lyase activity
CXR48_RS11300	COG0300	oxidoreductase activity
CXR48_RS11305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS11310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CXR48_RS11315	COG1024	Enoyl-CoA hydratase
CXR48_RS11320	COG3425	synthase
CXR48_RS11325	COG2124	cytochrome p450
CXR48_RS11330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS11330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11330	COG3321	synthase
CXR48_RS11330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11335	COG3321	synthase
CXR48_RS11335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS11335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11340	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11340	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS11340	COG3321	synthase
CXR48_RS11340	COG0300	oxidoreductase activity
CXR48_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11345	COG3321	synthase
CXR48_RS11345	COG0300	oxidoreductase activity
CXR48_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS11350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11350	COG3321	synthase
CXR48_RS11355	COG0300	oxidoreductase activity
CXR48_RS11355	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS11355	COG3321	synthase
CXR48_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS11360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR48_RS11360	COG3321	synthase
CXR48_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS11370	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS11385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CXR48_RS11385	COG2070	2-Nitropropane dioxygenase
CXR48_RS11395	COG0250	Participates in transcription elongation, termination and antitermination
CXR48_RS11420	COG0596	Alpha beta hydrolase
CXR48_RS11435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CXR48_RS11440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CXR48_RS11455	COG0706	membrane insertase activity
CXR48_RS11460	COG2195	Cleaves the N-terminal amino acid of tripeptides
CXR48_RS11465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR48_RS11470	COG0346	lactoylglutathione lyase activity
CXR48_RS11475	COG1376	ErfK ybiS ycfS ynhG family protein
CXR48_RS11480	COG4129	membrane
CXR48_RS11485	COG1126	abc transporter atp-binding protein
CXR48_RS11490	COG0765	amino acid transport
CXR48_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS11505	COG1597	lipid kinase activity
CXR48_RS11510	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR48_RS11515	COG0022	dehydrogenase e1 component
CXR48_RS11520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXR48_RS11525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR48_RS11530	COG3426	butyrate kinase activity
CXR48_RS11535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR48_RS11540	COG0280	phosphate acetyltransferase
CXR48_RS11545	COG3829	transcription factor binding
CXR48_RS11545	COG3290	protein histidine kinase activity
CXR48_RS11555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CXR48_RS11560	COG2079	MmgE PrpD family protein
CXR48_RS11565	COG0372	Belongs to the citrate synthase family
CXR48_RS11570	COG1960	acyl-CoA dehydrogenase activity
CXR48_RS11575	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR48_RS11580	COG0183	Belongs to the thiolase family
CXR48_RS11585	COG0584	glycerophosphoryl diester phosphodiesterase
CXR48_RS11590	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS11610	COG1902	pentaerythritol trinitrate reductase activity
CXR48_RS11625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXR48_RS11630	COG0745	RESPONSE REGULATOR receiver
CXR48_RS11635	COG0750	zinc metalloprotease
CXR48_RS11640	COG0497	DNA recombination
CXR48_RS11650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CXR48_RS11660	COG0142	geranyltranstransferase activity
CXR48_RS11670	COG1570	exodeoxyribonuclease VII activity
CXR48_RS11685	COG1302	Protein conserved in bacteria
CXR48_RS11690	COG0439	Biotin carboxylase
CXR48_RS11695	COG0511	ligase activity, forming carbon-carbon bonds
CXR48_RS11735	COG3854	ATPases associated with a variety of cellular activities
CXR48_RS11750	COG0006	proline dipeptidase activity
CXR48_RS11760	COG3872	metal-dependent enzyme
CXR48_RS11770	COG1752	Esterase of the alpha-beta hydrolase superfamily
CXR48_RS11785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR48_RS11805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR48_RS11820	COG1396	sequence-specific DNA binding
CXR48_RS11830	COG0681	Belongs to the peptidase S26 family
CXR48_RS11855	COG4940	Competence protein ComGF
CXR48_RS11865	COG4970	Tfp pilus assembly protein FimT
CXR48_RS11870	COG4537	Required for transformation and DNA binding
CXR48_RS11875	COG1459	type II secretion system
CXR48_RS11880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CXR48_RS11885	COG0598	Magnesium transport protein CorA
CXR48_RS11890	COG1253	flavin adenine dinucleotide binding
CXR48_RS11895	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS11905	COG1393	Belongs to the ArsC family
CXR48_RS11915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS11925	COG0011	TIGRFAM Protein of
CXR48_RS11935	COG2866	Carboxypeptidase
CXR48_RS11940	COG1940	carbohydrate kinase activity
CXR48_RS11945	COG4483	Protein conserved in bacteria
CXR48_RS11950	COG1757	Na H antiporter
CXR48_RS11960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CXR48_RS11975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXR48_RS11980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR48_RS11985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR48_RS11990	COG0581	inorganic phosphate transmembrane transporter activity
CXR48_RS11995	COG0573	inorganic phosphate transmembrane transporter activity
CXR48_RS12000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXR48_RS12005	COG0768	penicillin binding
CXR48_RS12010	COG0477	Major facilitator Superfamily
CXR48_RS12015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXR48_RS12020	COG2839	Protein conserved in bacteria
CXR48_RS12025	COG5521	maltodextrose utilization protein MalA
CXR48_RS12030	COG1388	LysM domain
CXR48_RS12040	COG4709	membrane
CXR48_RS12045	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CXR48_RS12050	COG0735	belongs to the Fur family
CXR48_RS12055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS12070	COG0513	Belongs to the DEAD box helicase family
CXR48_RS12085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXR48_RS12090	COG2384	SAM-dependent methyltransferase
CXR48_RS12095	COG2010	Cytochrome c
CXR48_RS12100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXR48_RS12105	COG0358	DNA primase activity
CXR48_RS12120	COG0517	IMP dehydrogenase activity
CXR48_RS12125	COG0751	glycine-tRNA ligase activity
CXR48_RS12145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXR48_RS12150	COG0295	cytidine deaminase activity
CXR48_RS12155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CXR48_RS12165	COG1480	7TM receptor with intracellular HD hydrolase
CXR48_RS12170	COG1702	phosphate starvation-inducible protein PhoH
CXR48_RS12175	COG0561	phosphatase activity
CXR48_RS12190	COG4864	UPF0365 protein
CXR48_RS12195	COG1030	water channel activity
CXR48_RS12200	COG1610	YqeY-like protein
CXR48_RS12210	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXR48_RS12215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXR48_RS12220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXR48_RS12250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXR48_RS12265	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS12280	COG1466	dna polymerase III delta subunit
CXR48_RS12290	COG2333	competence protein COMEC
CXR48_RS12290	COG0658	competence protein
CXR48_RS12295	COG2131	deaminase
CXR48_RS12300	COG1555	photosystem II stabilization
CXR48_RS12300	COG1596	polysaccharide export
CXR48_RS12305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CXR48_RS12310	COG2226	methyltransferase
CXR48_RS12315	COG0799	negative regulation of ribosome biogenesis
CXR48_RS12320	COG1713	HD superfamily hydrolase involved in NAD metabolism
CXR48_RS12330	COG1534	Rna-binding protein
CXR48_RS12335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR48_RS12340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CXR48_RS12345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CXR48_RS12355	COG2755	lipolytic protein G-D-S-L family
CXR48_RS12365	COG0398	Pfam SNARE associated Golgi protein
CXR48_RS12395	COG3708	Transcriptional regulator
CXR48_RS12395	COG2207	Transcriptional regulator
CXR48_RS12405	COG0563	adenylate kinase activity
CXR48_RS12415	COG2814	Major facilitator Superfamily
CXR48_RS12420	COG0456	acetyltransferase
CXR48_RS12425	COG2318	DinB family
CXR48_RS12435	COG0561	phosphatase activity
CXR48_RS12440	COG0561	phosphatase activity
CXR48_RS12450	COG1482	cell wall glycoprotein biosynthetic process
CXR48_RS12455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXR48_RS12455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXR48_RS12455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS12460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS12460	COG3711	transcriptional antiterminator
CXR48_RS12470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXR48_RS12475	COG0583	DNA-binding transcription factor activity
CXR48_RS12480	COG2814	Major facilitator Superfamily
CXR48_RS12485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXR48_RS12485	COG2124	cytochrome p450
CXR48_RS12490	COG1309	transcriptional regulator
CXR48_RS12495	COG2226	methyltransferase
CXR48_RS12510	COG2116	formate transmembrane transporter activity
CXR48_RS12515	COG5609	conserved protein (DUF2294)
CXR48_RS12520	COG3383	formate dehydrogenase (NAD+) activity
CXR48_RS12525	COG2427	Protein of unknown function (DUF1641)
CXR48_RS12535	COG0626	cystathionine gamma-synthase activity
CXR48_RS12540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXR48_RS12565	COG0768	penicillin binding
CXR48_RS12580	COG0826	peptidase U32
CXR48_RS12585	COG0826	peptidase U32
CXR48_RS12590	COG4122	O-methyltransferase activity
CXR48_RS12595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXR48_RS12610	COG4472	Bacterial protein of unknown function (DUF965)
CXR48_RS12620	COG0628	permease
CXR48_RS12625	COG1126	abc transporter atp-binding protein
CXR48_RS12630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS12635	COG0765	amino acid transport
CXR48_RS12640	COG0765	amino acid transport
CXR48_RS12655	COG3881	PFAM PRC-barrel domain
CXR48_RS12660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXR48_RS12665	COG0457	Tetratricopeptide repeat
CXR48_RS12675	COG1104	cysteine desulfurase activity
CXR48_RS12680	COG1959	2 iron, 2 sulfur cluster binding
CXR48_RS12685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXR48_RS12690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXR48_RS12710	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS12710	COG3103	Sh3 type 3 domain protein
CXR48_RS12710	COG4991	sh3 domain protein
CXR48_RS12720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXR48_RS12730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXR48_RS12730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CXR48_RS12735	COG5416	Lipopolysaccharide assembly protein A domain
CXR48_RS12740	COG0490	domain, Protein
CXR48_RS12745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR48_RS12745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR48_RS12755	COG2244	polysaccharide biosynthetic process
CXR48_RS12760	COG2323	membrane
CXR48_RS12770	COG1862	Preprotein translocase
CXR48_RS12815	COG1388	LysM domain
CXR48_RS12825	COG0157	Belongs to the NadC ModD family
CXR48_RS12830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CXR48_RS12835	COG1104	cysteine desulfurase activity
CXR48_RS12840	COG1827	regulation of RNA biosynthetic process
CXR48_RS12845	COG0077	Prephenate dehydratase
CXR48_RS12860	COG3290	protein histidine kinase activity
CXR48_RS12865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXR48_RS12870	COG2868	ribosomal protein
CXR48_RS12880	COG1994	Peptidase M50
CXR48_RS12885	COG0739	heme binding
CXR48_RS12890	COG2894	cell division
CXR48_RS12900	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CXR48_RS12910	COG1077	Cell shape determining protein MreB Mrl
CXR48_RS12930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXR48_RS12935	COG0285	dihydrofolate synthase activity
CXR48_RS12940	COG0525	valine-tRNA ligase activity
CXR48_RS12950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CXR48_RS12955	COG1388	LysM domain
CXR48_RS12965	COG0113	porphobilinogen synthase activity
CXR48_RS12970	COG1587	Uroporphyrinogen-III synthase
CXR48_RS12980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXR48_RS13000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXR48_RS13005	COG0470	DNA polymerase III
CXR48_RS13005	COG1067	ATP-dependent peptidase activity
CXR48_RS13020	COG0457	Tetratricopeptide repeat
CXR48_RS13020	COG1477	protein flavinylation
CXR48_RS13035	COG0473	3-isopropylmalate dehydrogenase activity
CXR48_RS13050	COG0440	acetolactate synthase activity
CXR48_RS13055	COG0028	Belongs to the TPP enzyme family
CXR48_RS13080	COG0622	Phosphoesterase
CXR48_RS13085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXR48_RS13095	COG5401	PFAM Sporulation and spore germination
CXR48_RS13105	COG1846	Transcriptional regulator
CXR48_RS13110	COG2197	response regulator
CXR48_RS13115	COG0824	Thioesterase
CXR48_RS13120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXR48_RS13125	COG1053	succinate dehydrogenase
CXR48_RS13130	COG2009	succinate dehydrogenase
CXR48_RS13135	COG1719	4-vinyl reductase, 4VR
CXR48_RS13140	COG0527	aspartate kinase activity
CXR48_RS13155	COG3118	belongs to the thioredoxin family
CXR48_RS13160	COG3534	alpha-L-arabinofuranosidase
CXR48_RS13165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR48_RS13170	COG2086	electron transfer activity
CXR48_RS13175	COG1024	Enoyl-CoA hydratase
CXR48_RS13180	COG1309	transcriptional regulator
CXR48_RS13185	COG0318	PFAM AMP-dependent synthetase and ligase
CXR48_RS13195	COG3766	membrane
CXR48_RS13205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CXR48_RS13205	COG1796	DNA polymerase
CXR48_RS13210	COG1286	toxin biosynthetic process
CXR48_RS13225	COG0072	phenylalanine-tRNA ligase activity
CXR48_RS13225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR48_RS13230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXR48_RS13235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR48_RS13245	COG3835	regulator
CXR48_RS13250	COG0277	FAD linked oxidase domain protein
CXR48_RS13255	COG0247	lactate metabolic process
CXR48_RS13260	COG1966	Carbon starvation protein
CXR48_RS13265	COG3534	alpha-L-arabinofuranosidase
CXR48_RS13270	COG0395	ABC-type sugar transport system, permease component
CXR48_RS13275	COG1175	transmembrane transport
CXR48_RS13280	COG1653	transport
CXR48_RS13290	COG0647	UMP catabolic process
CXR48_RS13295	COG0235	Class ii aldolase
CXR48_RS13300	COG1069	ribulokinase activity
CXR48_RS13305	COG2160	L-arabinose isomerase activity
CXR48_RS13310	COG3507	Belongs to the glycosyl hydrolase 43 family
CXR48_RS13315	COG1363	Peptidase, m42
CXR48_RS13325	COG3326	Membrane
CXR48_RS13330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXR48_RS13340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXR48_RS13345	COG1346	cytolysis
CXR48_RS13350	COG1380	Effector of murein hydrolase LrgA
CXR48_RS13355	COG3279	Response regulator of the LytR AlgR family
CXR48_RS13360	COG3275	phosphorelay sensor kinase activity
CXR48_RS13370	COG1011	Hydrolase
CXR48_RS13385	COG0398	Pfam SNARE associated Golgi protein
CXR48_RS13390	COG1484	DNA-dependent DNA replication
CXR48_RS13395	COG3611	Membrane attachment protein
CXR48_RS13410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXR48_RS13415	COG1733	regulation of RNA biosynthetic process
CXR48_RS13420	COG2814	Major facilitator Superfamily
CXR48_RS13425	COG0656	L-ascorbic acid biosynthetic process
CXR48_RS13430	COG0237	dephospho-CoA kinase activity
CXR48_RS13435	COG1971	Probably functions as a manganese efflux pump
CXR48_RS13440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR48_RS13445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR48_RS13445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR48_RS13450	COG5002	protein histidine kinase activity
CXR48_RS13455	COG0745	RESPONSE REGULATOR receiver
CXR48_RS13465	COG0538	isocitrate dehydrogenase activity
CXR48_RS13470	COG0372	Belongs to the citrate synthase family
CXR48_RS13490	COG0628	permease
CXR48_RS13495	COG3030	protein affecting phage T7 exclusion by the F plasmid
CXR48_RS13500	COG0469	pyruvate kinase activity
CXR48_RS13520	COG0281	malic enzyme
CXR48_RS13525	COG0587	DNA-directed DNA polymerase activity
CXR48_RS13545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CXR48_RS13555	COG4109	DRTGG domain
CXR48_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS13580	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXR48_RS13590	COG0827	DNA restriction-modification system
CXR48_RS13595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CXR48_RS13600	COG3874	Sporulation protein YtfJ
CXR48_RS13610	COG1714	RDD family
CXR48_RS13615	COG0616	signal peptide processing
CXR48_RS13620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR48_RS13625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CXR48_RS13630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR48_RS13645	COG1104	cysteine desulfurase activity
CXR48_RS13650	COG1114	Component of the transport system for branched-chain amino acids
CXR48_RS13660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CXR48_RS13665	COG1309	transcriptional regulator
CXR48_RS13670	COG1956	GAF domain-containing protein
CXR48_RS13675	COG2199	diguanylate cyclase activity
CXR48_RS13675	COG2203	Gaf domain
CXR48_RS13695	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS13700	COG4282	regulation of fungal-type cell wall biogenesis
CXR48_RS13710	COG1017	nitric oxide dioxygenase activity
CXR48_RS13710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR48_RS13720	COG0693	protein deglycase activity
CXR48_RS13735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CXR48_RS13740	COG1378	Sugar-specific transcriptional regulator TrmB
CXR48_RS13765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR48_RS13770	COG0454	-acetyltransferase
CXR48_RS13775	COG0517	IMP dehydrogenase activity
CXR48_RS13780	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXR48_RS13785	COG1360	Flagellar Motor Protein
CXR48_RS13790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CXR48_RS13795	COG1609	Transcriptional regulator
CXR48_RS13800	COG1605	Chorismate mutase
CXR48_RS13800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CXR48_RS13805	COG3118	belongs to the thioredoxin family
CXR48_RS13810	COG4980	gas vesicle protein
CXR48_RS13815	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CXR48_RS13825	COG1674	ftsk spoiiie
CXR48_RS13830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR48_RS13840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS13850	COG1363	Peptidase, m42
CXR48_RS13855	COG5584	Small secreted protein
CXR48_RS13860	COG0281	malic enzyme
CXR48_RS13865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR48_RS13880	COG0510	thiamine kinase activity
CXR48_RS13885	COG1597	lipid kinase activity
CXR48_RS13895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CXR48_RS13900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXR48_RS13905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR48_RS13910	COG2252	PERMEase
CXR48_RS13915	COG4473	ABC transporter
CXR48_RS13920	COG1131	(ABC) transporter
CXR48_RS13930	COG1349	DNA-binding transcription factor activity
CXR48_RS13935	COG1187	pseudouridine synthase activity
CXR48_RS13940	COG2244	polysaccharide biosynthetic process
CXR48_RS13945	COG2081	HI0933 family
CXR48_RS13950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR48_RS13960	COG1609	Transcriptional regulator
CXR48_RS13965	COG1653	transport
CXR48_RS13970	COG1175	transmembrane transport
CXR48_RS13975	COG0395	ABC-type sugar transport system, permease component
CXR48_RS13980	COG1486	melibiose metabolic process
CXR48_RS13990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR48_RS14005	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR48_RS14005	COG2202	Pas domain
CXR48_RS14010	COG2814	Major facilitator Superfamily
CXR48_RS14015	COG5522	Integral membrane protein (intg_mem_TP0381)
CXR48_RS14020	COG0577	efflux transmembrane transporter activity
CXR48_RS14025	COG1136	(ABC) transporter
CXR48_RS14030	COG2205	protein histidine kinase activity
CXR48_RS14035	COG0745	RESPONSE REGULATOR receiver
CXR48_RS14040	COG0577	efflux transmembrane transporter activity
CXR48_RS14045	COG1136	(ABC) transporter
CXR48_RS14065	COG1131	(ABC) transporter
CXR48_RS14070	COG1725	Transcriptional regulator
CXR48_RS14080	COG0640	Transcriptional regulator
CXR48_RS14085	COG0477	Major facilitator Superfamily
CXR48_RS14090	COG1242	4 iron, 4 sulfur cluster binding
CXR48_RS14095	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CXR48_RS14105	COG0584	glycerophosphoryl diester phosphodiesterase
CXR48_RS14115	COG2267	carboxylic ester hydrolase activity
CXR48_RS14120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CXR48_RS14125	COG1113	amino acid transport
CXR48_RS14130	COG0367	asparagine synthase
CXR48_RS14150	COG1506	peptidase
CXR48_RS14155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXR48_RS14160	COG1116	anion transmembrane transporter activity
CXR48_RS14165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR48_RS14170	COG0494	nUDIX hydrolase
CXR48_RS14175	COG4824	toxin secretion phage lysis holin
CXR48_RS14180	COG0783	Belongs to the Dps family
CXR48_RS14205	COG0288	reversible hydration of carbon dioxide
CXR48_RS14215	COG1271	oxidase subunit
CXR48_RS14220	COG1294	oxidase, subunit
CXR48_RS14235	COG4948	Mandelate Racemase Muconate Lactonizing
CXR48_RS14245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXR48_RS14250	COG0596	Alpha beta hydrolase
CXR48_RS14260	COG1169	isochorismate synthase
CXR48_RS14265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXR48_RS14270	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CXR48_RS14395	COG3859	Proton-coupled thiamine transporter YuaJ
CXR48_RS14400	COG2268	Band 7 protein
CXR48_RS14405	COG1585	Membrane protein implicated in regulation of membrane protease activity
CXR48_RS14410	COG2318	DinB family
CXR48_RS14420	COG1454	alcohol dehydrogenase
CXR48_RS14425	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS14430	COG1510	regulation of RNA biosynthetic process
CXR48_RS14440	COG0569	domain protein
CXR48_RS14445	COG1705	Flagellar rod assembly protein muramidase FlgJ
CXR48_RS14450	COG1017	nitric oxide dioxygenase activity
CXR48_RS14450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR48_RS14475	COG0628	permease
CXR48_RS14480	COG0673	inositol 2-dehydrogenase activity
CXR48_RS14485	COG0693	protein deglycase activity
CXR48_RS14490	COG0840	transmembrane signaling receptor activity
CXR48_RS14495	COG0840	transmembrane signaling receptor activity
CXR48_RS14500	COG0840	transmembrane signaling receptor activity
CXR48_RS14505	COG0840	transmembrane signaling receptor activity
CXR48_RS14520	COG2070	2-Nitropropane dioxygenase
CXR48_RS14525	COG0432	Pfam Uncharacterised protein family UPF0047
CXR48_RS14530	COG0366	Alpha amylase catalytic
CXR48_RS14535	COG1253	flavin adenine dinucleotide binding
CXR48_RS14540	COG2738	Putative neutral zinc metallopeptidase
CXR48_RS14555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXR48_RS14585	COG1335	isochorismatase
CXR48_RS14595	COG1979	alcohol dehydrogenase
CXR48_RS14600	COG1979	alcohol dehydrogenase
CXR48_RS14605	COG2155	Conserved Protein
CXR48_RS14610	COG1098	S1 RNA binding domain
CXR48_RS14615	COG0436	Aminotransferase
CXR48_RS14620	COG1522	sequence-specific DNA binding
CXR48_RS14625	COG2267	carboxylic ester hydrolase activity
CXR48_RS14635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CXR48_RS14640	COG2205	protein histidine kinase activity
CXR48_RS14650	COG5018	Exonuclease
CXR48_RS14655	COG2814	Major facilitator Superfamily
CXR48_RS14660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR48_RS14665	COG3011	Protein conserved in bacteria
CXR48_RS14675	COG3290	protein histidine kinase activity
CXR48_RS14680	COG4565	transcriptional regulatory protein
CXR48_RS14685	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR48_RS14690	COG3845	ABC transporter
CXR48_RS14695	COG4603	Belongs to the binding-protein-dependent transport system permease family
CXR48_RS14700	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXR48_RS14710	COG2111	Na H antiporter
CXR48_RS14710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR48_RS14715	COG2111	Na H antiporter
CXR48_RS14720	COG1006	Multisubunit Na H antiporter MnhC subunit
CXR48_RS14725	COG0651	ATP synthesis coupled electron transport
CXR48_RS14730	COG1863	multisubunit Na H antiporter MnhE subunit
CXR48_RS14735	COG2212	antiporter activity
CXR48_RS14740	COG1320	monovalent cation:proton antiporter activity
CXR48_RS14745	COG2050	protein possibly involved in aromatic compounds catabolism
CXR48_RS14750	COG2197	response regulator
CXR48_RS14755	COG4585	Histidine kinase
CXR48_RS14765	COG0142	geranyltranstransferase activity
CXR48_RS14780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CXR48_RS14785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXR48_RS14790	COG1335	isochorismatase
CXR48_RS14795	COG5506	Protein of unknown function (DUF1694)
CXR48_RS14810	COG0628	permease
CXR48_RS14820	COG1418	mRNA catabolic process
CXR48_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS14835	COG1511	domain protein
CXR48_RS14840	COG0433	COG0433 Predicted ATPase
CXR48_RS14840	COG1674	ftsk spoiiie
CXR48_RS14845	COG4499	WXG100 protein secretion system (Wss), protein YukC
CXR48_RS14850	COG5417	Belongs to the EsaB family
CXR48_RS14855	COG4842	Belongs to the WXG100 family
CXR48_RS14860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CXR48_RS14860	COG2508	Transcriptional regulator
CXR48_RS14865	COG0686	Belongs to the AlaDH PNT family
CXR48_RS14870	COG5634	Uncharacterized conserved protein (DUF2278)
CXR48_RS14875	COG3251	PFAM MbtH domain protein
CXR48_RS14880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR48_RS14885	COG1535	isochorismatase
CXR48_RS14885	COG3433	isochorismatase activity
CXR48_RS14890	COG1021	2,3-dihydroxybenzoate-AMP ligase
CXR48_RS14895	COG1169	isochorismate synthase
CXR48_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS14905	COG2819	hydrolase of the alpha beta superfamily
CXR48_RS14910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXR48_RS14915	COG1268	BioY protein
CXR48_RS14920	COG2056	Na+-H+ antiporter family
CXR48_RS14930	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CXR48_RS14935	COG3584	3D domain protein
CXR48_RS14950	COG1252	NADH dehydrogenase
CXR48_RS14980	COG1131	(ABC) transporter
CXR48_RS15005	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CXR48_RS15020	COG0316	Belongs to the HesB IscA family
CXR48_RS15030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CXR48_RS15040	COG1252	NADH dehydrogenase
CXR48_RS15045	COG4837	Protein of unknown function (DUF1462)
CXR48_RS15050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CXR48_RS15055	COG0823	Involved in the tonB-independent uptake of proteins
CXR48_RS15055	COG1506	peptidase
CXR48_RS15055	COG4946	Tricorn protease homolog
CXR48_RS15065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CXR48_RS15070	COG0460	homoserine dehydrogenase
CXR48_RS15075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CXR48_RS15080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXR48_RS15085	COG0647	UMP catabolic process
CXR48_RS15090	COG2445	Protein of unknown function DUF86
CXR48_RS15095	COG4470	Protein conserved in bacteria
CXR48_RS15110	COG0739	heme binding
CXR48_RS15120	COG0737	Belongs to the 5'-nucleotidase family
CXR48_RS15125	COG0730	response to heat
CXR48_RS15130	COG1801	Protein of unknown function DUF72
CXR48_RS15145	COG2508	Transcriptional regulator
CXR48_RS15165	COG2814	Major facilitator Superfamily
CXR48_RS15170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CXR48_RS15175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR48_RS15180	COG2356	endonuclease I
CXR48_RS15185	COG3842	ATPase activity
CXR48_RS15190	COG2188	Transcriptional regulator
CXR48_RS15195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR48_RS15200	COG0395	ABC-type sugar transport system, permease component
CXR48_RS15205	COG1175	transmembrane transport
CXR48_RS15210	COG1653	transport
CXR48_RS15215	COG2222	sugar isomerase
CXR48_RS15220	COG0789	Transcriptional regulator
CXR48_RS15235	COG0322	excinuclease ABC activity
CXR48_RS15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR48_RS15245	COG2226	methyltransferase
CXR48_RS15255	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS15260	COG0719	Fe-S assembly protein
CXR48_RS15265	COG0822	iron-sulfur transferase activity
CXR48_RS15270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXR48_RS15275	COG0719	Fe-S assembly protein
CXR48_RS15280	COG0396	ATPase activity
CXR48_RS15290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR48_RS15295	COG1464	Belongs to the NlpA lipoprotein family
CXR48_RS15300	COG2011	ABC-type metal ion transport system permease component
CXR48_RS15305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXR48_RS15315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR48_RS15320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CXR48_RS15335	COG1393	Belongs to the ArsC family
CXR48_RS15340	COG1960	acyl-CoA dehydrogenase activity
CXR48_RS15345	COG0183	Belongs to the thiolase family
CXR48_RS15350	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR48_RS15350	COG1024	Enoyl-CoA hydratase
CXR48_RS15365	COG0477	Major facilitator Superfamily
CXR48_RS15375	COG5577	PFAM Coat F domain
CXR48_RS15380	COG1846	Transcriptional regulator
CXR48_RS15385	COG0477	Major facilitator Superfamily
CXR48_RS15390	COG0583	DNA-binding transcription factor activity
CXR48_RS15410	COG1120	ATPase activity
CXR48_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS15430	COG0783	Belongs to the Dps family
CXR48_RS15435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR48_RS15440	COG0745	RESPONSE REGULATOR receiver
CXR48_RS15445	COG2205	protein histidine kinase activity
CXR48_RS15445	COG2770	Histidine kinase
CXR48_RS15455	COG1309	transcriptional regulator
CXR48_RS15460	COG0114	fumarate hydratase activity
CXR48_RS15470	COG0697	spore germination
CXR48_RS15475	COG0814	amino acid
CXR48_RS15485	COG2197	response regulator
CXR48_RS15490	COG4585	Histidine kinase
CXR48_RS15495	COG4758	membrane
CXR48_RS15500	COG3595	metallopeptidase activity
CXR48_RS15505	COG1842	Phage shock protein A
CXR48_RS15510	COG4758	membrane
CXR48_RS15515	COG2814	Major facilitator Superfamily
CXR48_RS15520	COG2096	Adenosyltransferase
CXR48_RS15525	COG1120	ATPase activity
CXR48_RS15530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS15535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR48_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS15545	COG3386	PFAM SMP-30 Gluconolaconase
CXR48_RS15550	COG2205	protein histidine kinase activity
CXR48_RS15555	COG0745	RESPONSE REGULATOR receiver
CXR48_RS15565	COG1191	sigma factor activity
CXR48_RS15575	COG2140	Oxalate decarboxylase
CXR48_RS15585	COG1120	ATPase activity
CXR48_RS15590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS15595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS15600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR48_RS15605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CXR48_RS15610	COG0531	amino acid
CXR48_RS15625	COG1988	membrane-bound metal-dependent
CXR48_RS15630	COG1368	sulfuric ester hydrolase activity
CXR48_RS15635	COG1910	domain protein
CXR48_RS15640	COG0725	ABC transporter, periplasmic molybdate-binding protein
CXR48_RS15645	COG4149	molybdate abc transporter
CXR48_RS15650	COG2197	response regulator
CXR48_RS15655	COG3850	Histidine kinase
CXR48_RS15660	COG1131	(ABC) transporter
CXR48_RS15670	COG0842	Transport permease protein
CXR48_RS15675	COG0656	L-ascorbic acid biosynthetic process
CXR48_RS15700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXR48_RS15705	COG3973	AAA domain
CXR48_RS15710	COG2860	membrane
CXR48_RS15720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXR48_RS15725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR48_RS15730	COG2217	Heavy metal translocating P-type atpase
CXR48_RS15735	COG2217	Heavy metal translocating P-type atpase
CXR48_RS15740	COG2608	mercury ion transmembrane transporter activity
CXR48_RS15745	COG1937	Protein conserved in bacteria
CXR48_RS15750	COG0673	inositol 2-dehydrogenase activity
CXR48_RS15760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS15765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CXR48_RS15770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS15775	COG1126	abc transporter atp-binding protein
CXR48_RS15780	COG0765	amino acid transport
CXR48_RS15785	COG0765	amino acid transport
CXR48_RS15790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS15795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR48_RS15800	COG0454	-acetyltransferase
CXR48_RS15805	COG0583	DNA-binding transcription factor activity
CXR48_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS15815	COG2732	(Barnase) inhibitor
CXR48_RS15830	COG0557	exoribonuclease II activity
CXR48_RS15835	COG1647	Serine aminopeptidase, S33
CXR48_RS15840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXR48_RS15845	COG1476	TRANSCRIPTIONal
CXR48_RS15850	COG1396	sequence-specific DNA binding
CXR48_RS15855	COG1396	sequence-specific DNA binding
CXR48_RS15860	COG1733	regulation of RNA biosynthetic process
CXR48_RS15885	COG1131	(ABC) transporter
CXR48_RS15890	COG1174	glycine betaine transport
CXR48_RS15895	COG1732	Glycine betaine
CXR48_RS15900	COG1174	glycine betaine transport
CXR48_RS15905	COG0517	IMP dehydrogenase activity
CXR48_RS15905	COG1125	glycine betaine transport
CXR48_RS15910	COG1510	regulation of RNA biosynthetic process
CXR48_RS15915	COG1174	glycine betaine transport
CXR48_RS15920	COG1732	Glycine betaine
CXR48_RS15925	COG1174	glycine betaine transport
CXR48_RS15930	COG1125	glycine betaine transport
CXR48_RS15930	COG0517	IMP dehydrogenase activity
CXR48_RS15935	COG1510	regulation of RNA biosynthetic process
CXR48_RS15940	COG2095	MarC family integral membrane protein
CXR48_RS15945	COG3064	Membrane
CXR48_RS15950	COG4640	response to antibiotic
CXR48_RS15955	COG0456	acetyltransferase
CXR48_RS15970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR48_RS15985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXR48_RS15990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR48_RS15995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXR48_RS16005	COG2234	aminopeptidase activity
CXR48_RS16025	COG0126	phosphoglycerate kinase activity
CXR48_RS16035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXR48_RS16040	COG2390	Transcriptional regulator
CXR48_RS16045	COG2814	Major facilitator Superfamily
CXR48_RS16050	COG1609	Transcriptional regulator
CXR48_RS16055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS16065	COG0583	DNA-binding transcription factor activity
CXR48_RS16070	COG0697	spore germination
CXR48_RS16075	COG1113	amino acid transport
CXR48_RS16080	COG1737	Transcriptional regulator
CXR48_RS16085	COG1070	Carbohydrate kinase
CXR48_RS16110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR48_RS16115	COG2186	Transcriptional regulator
CXR48_RS16120	COG1620	l-lactate permease
CXR48_RS16125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXR48_RS16135	COG5039	Polysaccharide pyruvyl transferase
CXR48_RS16140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXR48_RS16145	COG0110	maltose O-acetyltransferase activity
CXR48_RS16150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXR48_RS16155	COG2244	polysaccharide biosynthetic process
CXR48_RS16160	COG1216	Glycosyl transferase, family 2
CXR48_RS16165	COG5039	Polysaccharide pyruvyl transferase
CXR48_RS16170	COG1216	Glycosyl transferase, family 2
CXR48_RS16180	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS16185	COG1215	transferase activity, transferring glycosyl groups
CXR48_RS16190	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS16195	COG1086	Polysaccharide biosynthesis protein
CXR48_RS16200	COG0489	protein tyrosine kinase activity
CXR48_RS16205	COG3944	biosynthesis protein
CXR48_RS16210	COG1396	sequence-specific DNA binding
CXR48_RS16215	COG2272	Belongs to the type-B carboxylesterase lipase family
CXR48_RS16225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CXR48_RS16230	COG2364	Membrane
CXR48_RS16235	COG0456	acetyltransferase
CXR48_RS16240	COG3479	Phenolic acid decarboxylase
CXR48_RS16295	COG2223	nitrite transmembrane transporter activity
CXR48_RS16300	COG1609	Transcriptional regulator
CXR48_RS16310	COG0583	DNA-binding transcription factor activity
CXR48_RS16315	COG2828	Protein conserved in bacteria
CXR48_RS16320	COG0477	Major facilitator Superfamily
CXR48_RS16320	COG2814	Major facilitator Superfamily
CXR48_RS16325	COG1611	Belongs to the LOG family
CXR48_RS16330	COG1694	Mazg nucleotide pyrophosphohydrolase
CXR48_RS16335	COG0659	secondary active sulfate transmembrane transporter activity
CXR48_RS16340	COG0288	reversible hydration of carbon dioxide
CXR48_RS16350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXR48_RS16355	COG4290	ribonuclease
CXR48_RS16360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CXR48_RS16365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS16375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CXR48_RS16385	COG1051	belongs to the nudix hydrolase family
CXR48_RS16390	COG0492	ferredoxin-NADP+ reductase activity
CXR48_RS16395	COG3883	PFAM NLP P60 protein
CXR48_RS16395	COG0791	NLP P60 protein
CXR48_RS16400	COG0457	Tetratricopeptide repeat
CXR48_RS16405	COG5002	protein histidine kinase activity
CXR48_RS16410	COG0745	RESPONSE REGULATOR receiver
CXR48_RS16420	COG1132	(ABC) transporter
CXR48_RS16425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXR48_RS16425	COG0140	phosphoribosyl-ATP diphosphatase activity
CXR48_RS16450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXR48_RS16465	COG4990	cell redox homeostasis
CXR48_RS16470	COG0110	maltose O-acetyltransferase activity
CXR48_RS16490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXR48_RS16500	COG2188	Transcriptional regulator
CXR48_RS16505	COG1309	transcriptional regulator
CXR48_RS16510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXR48_RS16515	COG1950	PFAM Membrane protein of
CXR48_RS16520	COG1983	PspC domain protein
CXR48_RS16525	COG3595	metallopeptidase activity
CXR48_RS16540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR48_RS16550	COG4897	Protein conserved in bacteria
CXR48_RS16555	COG0574	Belongs to the PEP-utilizing enzyme family
CXR48_RS16555	COG3848	Pyruvate phosphate dikinase
CXR48_RS16560	COG1309	transcriptional regulator
CXR48_RS16565	COG2814	Major facilitator Superfamily
CXR48_RS16575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR48_RS16585	COG3409	Peptidoglycan-binding domain 1 protein
CXR48_RS16585	COG0793	Belongs to the peptidase S41A family
CXR48_RS16590	COG3420	alginic acid biosynthetic process
CXR48_RS16595	COG2177	Part of the ABC transporter FtsEX involved in
CXR48_RS16600	COG2884	Cell division ATP-binding protein ftsE
CXR48_RS16605	COG2010	Cytochrome c
CXR48_RS16610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS16625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CXR48_RS16640	COG1516	flagellar protein fliS
CXR48_RS16645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CXR48_RS16650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXR48_RS16670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXR48_RS16675	COG1256	bacterial-type flagellum assembly
CXR48_RS16675	COG4786	Flagellar basal body rod
CXR48_RS16680	COG3418	PFAM FlgN family protein
CXR48_RS16685	COG2747	anti-sigma28 factor FlgM
CXR48_RS16695	COG1040	competence protein
CXR48_RS16705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CXR48_RS16710	COG1307	EDD domain protein, DegV family
CXR48_RS16715	COG2197	response regulator
CXR48_RS16720	COG4585	Histidine kinase
CXR48_RS16725	COG1739	Uncharacterized protein family UPF0029
CXR48_RS16730	COG1316	TRANSCRIPTIONal
CXR48_RS16735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR48_RS16740	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS16745	COG1215	transferase activity, transferring glycosyl groups
CXR48_RS16750	COG3206	protein involved in exopolysaccharide biosynthesis
CXR48_RS16755	COG3307	-O-antigen
CXR48_RS16760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR48_RS16765	COG0297	glycogen (starch) synthase activity
CXR48_RS16765	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS16770	COG2244	polysaccharide biosynthetic process
CXR48_RS16780	COG2247	cell wall binding repeat
CXR48_RS16780	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR48_RS16785	COG2247	cell wall binding repeat
CXR48_RS16785	COG2385	sporulation resulting in formation of a cellular spore
CXR48_RS16795	COG1316	TRANSCRIPTIONal
CXR48_RS16800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CXR48_RS16805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CXR48_RS16810	COG1134	teichoic acid transport
CXR48_RS16815	COG1682	transport, permease protein
CXR48_RS16820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR48_RS16830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXR48_RS16835	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CXR48_RS16840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR48_RS16845	COG4193	domain, Protein
CXR48_RS16850	COG1482	cell wall glycoprotein biosynthetic process
CXR48_RS16855	COG0697	spore germination
CXR48_RS16860	COG0814	amino acid
CXR48_RS16870	COG1215	transferase activity, transferring glycosyl groups
CXR48_RS16875	COG2814	Major facilitator Superfamily
CXR48_RS16880	COG1316	TRANSCRIPTIONal
CXR48_RS16885	COG0561	phosphatase activity
CXR48_RS16890	COG2433	Pfam Transposase IS66
CXR48_RS16895	COG0791	NLP P60 protein
CXR48_RS16905	COG2843	Capsule synthesis protein
CXR48_RS16915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXR48_RS16925	COG0697	spore germination
CXR48_RS16930	COG0814	amino acid
CXR48_RS16940	COG1609	Transcriptional regulator
CXR48_RS16945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR48_RS16955	COG1129	ABC transporter
CXR48_RS16960	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR48_RS16965	COG1879	ABC-type sugar transport system periplasmic component
CXR48_RS16970	COG3103	Sh3 type 3 domain protein
CXR48_RS16975	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXR48_RS16980	COG3527	Alpha-acetolactate decarboxylase
CXR48_RS16985	COG0028	Belongs to the TPP enzyme family
CXR48_RS16990	COG0583	DNA-binding transcription factor activity
CXR48_RS16995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CXR48_RS17010	COG5337	Spore coat protein CotH
CXR48_RS17020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXR48_RS17030	COG0405	Gamma-glutamyltransferase
CXR48_RS17035	COG1522	sequence-specific DNA binding
CXR48_RS17040	COG2059	Chromate
CXR48_RS17045	COG2059	Chromate
CXR48_RS17055	COG0655	NAD(P)H dehydrogenase (quinone) activity
CXR48_RS17060	COG0583	DNA-binding transcription factor activity
CXR48_RS17105	COG5444	nuclease activity
CXR48_RS17120	COG3878	Protein conserved in bacteria
CXR48_RS17125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR48_RS17130	COG4464	protein tyrosine phosphatase activity
CXR48_RS17135	COG0489	protein tyrosine kinase activity
CXR48_RS17140	COG3944	biosynthesis protein
CXR48_RS17155	COG4715	Zinc finger, swim domain protein
CXR48_RS17160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR48_RS17165	COG0561	phosphatase activity
CXR48_RS17170	COG1349	DNA-binding transcription factor activity
CXR48_RS17175	COG0629	single-stranded DNA binding
CXR48_RS17200	COG0457	Tetratricopeptide repeat
CXR48_RS17205	COG4786	Flagellar basal body rod
CXR48_RS17210	COG4786	Flagellar basal body rod
CXR48_RS17215	COG1077	Cell shape determining protein MreB Mrl
CXR48_RS17220	COG1609	Transcriptional regulator
CXR48_RS17225	COG1846	Transcriptional regulator
CXR48_RS17230	COG2814	Major facilitator Superfamily
CXR48_RS17235	COG1953	Uracil, thiamine, allantoin
CXR48_RS17240	COG0477	Major facilitator Superfamily
CXR48_RS17245	COG1335	isochorismatase
CXR48_RS17250	COG0004	ammonium transporteR
CXR48_RS17255	COG0347	Belongs to the P(II) protein family
CXR48_RS17260	COG0772	Belongs to the SEDS family
CXR48_RS17265	COG0671	phosphoesterase, PA-phosphatase related
CXR48_RS17275	COG0739	heme binding
CXR48_RS17280	COG1247	-acetyltransferase
CXR48_RS17295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR48_RS17305	COG0726	polysaccharide deacetylase
CXR48_RS17315	COG1959	2 iron, 2 sulfur cluster binding
CXR48_RS17330	COG0831	urea catabolic process
CXR48_RS17335	COG3237	CsbD-like
CXR48_RS17340	COG1994	Peptidase M50
CXR48_RS17345	COG0457	Tetratricopeptide repeat
CXR48_RS17355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXR48_RS17360	COG2304	oxidoreductase activity
CXR48_RS17365	COG2304	oxidoreductase activity
CXR48_RS17370	COG2385	sporulation resulting in formation of a cellular spore
CXR48_RS17375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR48_RS17385	COG4836	Membrane
CXR48_RS17455	COG0698	ribose 5-phosphate isomerase
CXR48_RS17460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR48_RS17470	COG0009	L-threonylcarbamoyladenylate synthase
CXR48_RS17475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXR48_RS17495	COG2890	protein-(glutamine-N5) methyltransferase activity
CXR48_RS17500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXR48_RS17505	COG0346	lactoylglutathione lyase activity
CXR48_RS17510	COG0789	Transcriptional regulator
CXR48_RS17515	COG0679	Auxin Efflux Carrier
CXR48_RS17520	COG0281	malic enzyme
CXR48_RS17535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXR48_RS17540	COG1494	fructose-1,6-bisphosphatase
CXR48_RS17545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR48_RS17555	COG0191	fructose-bisphosphate aldolase activity
CXR48_RS17560	COG2204	response regulator
CXR48_RS17565	COG4821	SIS domain
CXR48_RS17580	COG0247	lactate metabolic process
CXR48_RS17580	COG2181	nitrate reductase activity
CXR48_RS17585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR48_RS17600	COG1132	(ABC) transporter
CXR48_RS17605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXR48_RS17615	COG2181	nitrate reductase activity
CXR48_RS17620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CXR48_RS17625	COG1140	nitrate reductase beta subunit
CXR48_RS17630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CXR48_RS17635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR48_RS17645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR48_RS17650	COG2223	nitrite transmembrane transporter activity
CXR48_RS17660	COG4506	Protein conserved in bacteria
CXR48_RS17665	COG0457	Tetratricopeptide repeat
CXR48_RS17710	COG0010	Belongs to the arginase family
CXR48_RS17715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXR48_RS17720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR48_RS17735	COG1994	Peptidase M50
CXR48_RS17740	COG1942	4-Oxalocrotonate Tautomerase
CXR48_RS17745	COG1846	Transcriptional regulator
CXR48_RS17755	COG0531	amino acid
CXR48_RS17760	COG3465	dGTPase activity
CXR48_RS17765	COG1078	dGTPase activity
CXR48_RS17780	COG1695	Transcriptional regulator
CXR48_RS17800	COG0583	DNA-binding transcription factor activity
CXR48_RS17805	COG2855	membrane
CXR48_RS17810	COG0280	phosphate acetyltransferase
CXR48_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS17825	COG0436	Aminotransferase
CXR48_RS17855	COG2814	Major facilitator Superfamily
CXR48_RS17860	COG2814	Major facilitator Superfamily
CXR48_RS17865	COG0833	amino acid
CXR48_RS17870	COG4187	Peptidase family M20/M25/M40
CXR48_RS17875	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS17880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR48_RS17890	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CXR48_RS17895	COG1091	dTDP-4-dehydrorhamnose reductase activity
CXR48_RS17900	COG1088	dTDP-glucose 4,6-dehydratase activity
CXR48_RS17905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CXR48_RS17910	COG3980	spore coat polysaccharide biosynthesis protein
CXR48_RS17915	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CXR48_RS17920	COG2089	acid synthase
CXR48_RS17925	COG0456	acetyltransferase
CXR48_RS17930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXR48_RS17935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR48_RS17940	COG0463	Glycosyl transferase, family 2
CXR48_RS17950	COG2363	Small membrane protein
CXR48_RS17955	COG2233	PERMEase
CXR48_RS17970	COG1216	Glycosyl transferase, family 2
CXR48_RS17985	COG1695	Transcriptional regulator
CXR48_RS17990	COG0351	phosphomethylpyrimidine kinase
CXR48_RS18000	COG1621	beta-fructofuranosidase activity
CXR48_RS18005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CXR48_RS18005	COG1263	PTS System
CXR48_RS18010	COG3711	transcriptional antiterminator
CXR48_RS18020	COG1404	Belongs to the peptidase S8 family
CXR48_RS18025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR48_RS18030	COG0778	Nitroreductase
CXR48_RS18035	COG1136	(ABC) transporter
CXR48_RS18055	COG0772	Belongs to the SEDS family
CXR48_RS18060	COG0454	-acetyltransferase
CXR48_RS18080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR48_RS18085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXR48_RS18090	COG2261	transglycosylase associated protein
CXR48_RS18095	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CXR48_RS18105	COG2246	polysaccharide biosynthetic process
CXR48_RS18110	COG1309	transcriptional regulator
CXR48_RS18130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR48_RS18135	COG2837	iron assimilation
CXR48_RS18155	COG0583	DNA-binding transcription factor activity
CXR48_RS18165	COG1346	cytolysis
CXR48_RS18170	COG4895	conserved protein (DUF2196)
CXR48_RS18175	COG0789	Transcriptional regulator
CXR48_RS18180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXR48_RS18185	COG0346	lactoylglutathione lyase activity
CXR48_RS18190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS18195	COG1404	Belongs to the peptidase S8 family
CXR48_RS18200	COG1442	glycosyl transferase family 8
CXR48_RS18205	COG1846	Transcriptional regulator
CXR48_RS18210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXR48_RS18215	COG2357	RelA SpoT domain protein
CXR48_RS18220	COG1575	Belongs to the MenA family. Type 1 subfamily
CXR48_RS18240	COG1696	Membrane protein involved in D-alanine export
CXR48_RS18250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CXR48_RS18255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR48_RS18260	COG1486	melibiose metabolic process
CXR48_RS18265	COG1447	Phosphotransferase system cellobiose-specific component IIA
CXR48_RS18270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS18275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS18280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR48_RS18280	COG3711	transcriptional antiterminator
CXR48_RS18295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS18300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR48_RS18310	COG0640	Transcriptional regulator
CXR48_RS18315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CXR48_RS18320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS18325	COG1447	Phosphotransferase system cellobiose-specific component IIA
CXR48_RS18330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CXR48_RS18335	COG2723	6-phospho-beta-galactosidase activity
CXR48_RS18340	COG1940	carbohydrate kinase activity
CXR48_RS18345	COG1482	cell wall glycoprotein biosynthetic process
CXR48_RS18355	COG0753	catalase activity
CXR48_RS18360	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CXR48_RS18365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXR48_RS18370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXR48_RS18375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXR48_RS18380	COG4988	ABC transporter
CXR48_RS18385	COG1294	oxidase, subunit
CXR48_RS18390	COG1271	oxidase subunit
CXR48_RS18395	COG3493	citrate carrier protein
CXR48_RS18400	COG0726	polysaccharide deacetylase
CXR48_RS18405	COG3842	ATPase activity
CXR48_RS18410	COG2508	Transcriptional regulator
CXR48_RS18415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS18425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXR48_RS18435	COG4894	glucomannan catabolic process
CXR48_RS18440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXR48_RS18445	COG0500	methyltransferase
CXR48_RS18450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CXR48_RS18465	COG0753	catalase activity
CXR48_RS18465	COG0693	protein deglycase activity
CXR48_RS18470	COG2851	Citrate transporter
CXR48_RS18475	COG2273	Hydrolase Family 16
CXR48_RS18485	COG2270	Major facilitator Superfamily
CXR48_RS18490	COG0513	Belongs to the DEAD box helicase family
CXR48_RS18545	COG0697	spore germination
CXR48_RS18550	COG0589	response to stress
CXR48_RS18565	COG0494	nUDIX hydrolase
CXR48_RS18570	COG3507	Belongs to the glycosyl hydrolase 43 family
CXR48_RS18595	COG0010	Belongs to the arginase family
CXR48_RS18600	COG0833	amino acid
CXR48_RS18605	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CXR48_RS18610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CXR48_RS18620	COG2390	Transcriptional regulator
CXR48_RS18625	COG0561	phosphatase activity
CXR48_RS18655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CXR48_RS18660	COG5294	Protein conserved in bacteria
CXR48_RS18665	COG0577	efflux transmembrane transporter activity
CXR48_RS18670	COG1136	(ABC) transporter
CXR48_RS18675	COG2205	protein histidine kinase activity
CXR48_RS18680	COG0745	RESPONSE REGULATOR receiver
CXR48_RS18695	COG1082	Xylose isomerase domain protein TIM barrel
CXR48_RS18705	COG2814	Major facilitator Superfamily
CXR48_RS18735	COG1349	DNA-binding transcription factor activity
CXR48_RS18740	COG0667	Aldo Keto reductase
CXR48_RS18745	COG2814	Major facilitator Superfamily
CXR48_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS18760	COG2197	response regulator
CXR48_RS18765	COG4585	Histidine kinase
CXR48_RS18770	COG3239	Fatty acid desaturase
CXR48_RS18780	COG1309	transcriptional regulator
CXR48_RS18785	COG1012	belongs to the aldehyde dehydrogenase family
CXR48_RS18790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR48_RS18800	COG0640	Transcriptional regulator
CXR48_RS18805	COG2814	Major facilitator Superfamily
CXR48_RS18810	COG1714	RDD family
CXR48_RS18820	COG0450	alkyl hydroperoxide reductase
CXR48_RS18825	COG3634	alkyl hydroperoxide reductase activity
CXR48_RS18830	COG1113	amino acid transport
CXR48_RS18840	COG2080	2 iron, 2 sulfur cluster binding
CXR48_RS18855	COG2068	MobA-Related Protein
CXR48_RS18860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CXR48_RS18920	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CXR48_RS18925	COG0667	Aldo Keto reductase
CXR48_RS18930	COG0456	acetyltransferase
CXR48_RS18935	COG0457	Tetratricopeptide repeat
CXR48_RS18940	COG0010	Belongs to the arginase family
CXR48_RS18945	COG0833	amino acid
CXR48_RS18950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR48_RS18955	COG5658	integral membrane protein
CXR48_RS18960	COG0640	Transcriptional regulator
CXR48_RS18965	COG3829	transcription factor binding
CXR48_RS18975	COG0488	(ABC) transporter
CXR48_RS18990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXR48_RS18995	COG3850	Histidine kinase
CXR48_RS18995	COG5002	protein histidine kinase activity
CXR48_RS19000	COG0745	RESPONSE REGULATOR receiver
CXR48_RS19005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR48_RS19010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CXR48_RS19015	COG4853	Protein conserved in bacteria
CXR48_RS19020	COG4863	YycH protein
CXR48_RS19025	COG5002	protein histidine kinase activity
CXR48_RS19030	COG0745	RESPONSE REGULATOR receiver
CXR48_RS19065	COG0346	lactoylglutathione lyase activity
CXR48_RS19070	COG0305	Participates in initiation and elongation during chromosome replication
CXR48_RS19090	COG3093	addiction module antidote protein HigA
CXR48_RS19095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CXR48_RS19100	COG0297	glycogen (starch) synthase activity
CXR48_RS19110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXR48_RS19115	COG0438	transferase activity, transferring glycosyl groups
CXR48_RS19135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CXR48_RS19140	COG4241	membrane
CXR48_RS19150	COG5577	PFAM Coat F domain
CXR48_RS19155	COG1733	regulation of RNA biosynthetic process
CXR48_RS19165	COG0697	spore germination
CXR48_RS19170	COG1621	beta-fructofuranosidase activity
CXR48_RS19175	COG1621	beta-fructofuranosidase activity
CXR48_RS19180	COG1802	Transcriptional regulator
CXR48_RS19185	COG2318	DinB family
CXR48_RS19190	COG2211	Major facilitator Superfamily
CXR48_RS19200	COG0778	Nitroreductase
CXR48_RS19205	COG1846	Transcriptional regulator
CXR48_RS19210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CXR48_RS19215	COG1846	Transcriptional regulator
CXR48_RS19230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR48_RS19235	COG0583	DNA-binding transcription factor activity
CXR48_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
CXR48_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR48_RS19255	COG0697	spore germination
CXR48_RS19265	COG1959	2 iron, 2 sulfur cluster binding
CXR48_RS19270	COG1396	sequence-specific DNA binding
CXR48_RS19280	COG1331	Highly conserved protein containing a thioredoxin domain
CXR48_RS19300	COG1331	Highly conserved protein containing a thioredoxin domain
CXR48_RS19305	COG1331	Highly conserved protein containing a thioredoxin domain
CXR48_RS19310	COG1266	CAAX protease self-immunity
CXR48_RS19315	COG0477	Major facilitator Superfamily
CXR48_RS19315	COG2814	Major facilitator Superfamily
CXR48_RS19320	COG0346	lactoylglutathione lyase activity
CXR48_RS19325	COG1609	Transcriptional regulator
CXR48_RS19330	COG0708	Exodeoxyribonuclease III
CXR48_RS19335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR48_RS19340	COG2169	Transcriptional regulator
CXR48_RS19350	COG0629	single-stranded DNA binding
CXR48_RS19360	COG0012	GTP binding
CXR48_RS19365	COG0243	molybdopterin cofactor binding
CXR48_RS19370	COG4481	Protein conserved in bacteria
CXR48_RS19375	COG3949	Membrane
CXR48_RS19390	COG1475	DNA binding
CXR48_RS19395	COG1192	Involved in chromosome partitioning
CXR48_RS19420	COG1847	R3H domain protein
CXR48_RS19425	COG0706	membrane insertase activity