locus-tag	class	description
DA376_RS00015	COG0629	single-stranded DNA binding
DA376_RS00025	COG0012	GTP binding
DA376_RS00030	COG0243	molybdopterin cofactor binding
DA376_RS00035	COG4481	Protein conserved in bacteria
DA376_RS00040	COG3949	Membrane
DA376_RS00055	COG1475	DNA binding
DA376_RS00060	COG1192	Involved in chromosome partitioning
DA376_RS00085	COG1847	R3H domain protein
DA376_RS00090	COG0706	membrane insertase activity
DA376_RS00115	COG0592	DNA-directed DNA polymerase activity
DA376_RS00120	COG2501	S4 domain
DA376_RS00135	COG0187	DNA topoisomerase II activity
DA376_RS00140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA376_RS00175	COG0516	GMP reductase activity
DA376_RS00175	COG0517	IMP dehydrogenase activity
DA376_RS00180	COG1686	Belongs to the peptidase S11 family
DA376_RS00200	COG1929	Belongs to the glycerate kinase type-1 family
DA376_RS00210	COG1428	Deoxynucleoside kinase
DA376_RS00215	COG1428	Deoxynucleoside kinase
DA376_RS00220	COG1388	LysM domain
DA376_RS00220	COG3858	chitin binding
DA376_RS00225	COG1335	isochorismatase
DA376_RS00230	COG0590	tRNA wobble adenosine to inosine editing
DA376_RS00240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DA376_RS00245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DA376_RS00250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DA376_RS00295	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DA376_RS00300	COG3853	Toxic anion resistance protein (TelA)
DA376_RS00305	COG1982	Orn Lys Arg decarboxylase major
DA376_RS00315	COG3870	Protein conserved in bacteria
DA376_RS00320	COG1728	Protein conserved in bacteria
DA376_RS00325	COG0470	DNA polymerase III
DA376_RS00330	COG1774	PSP1 C-terminal conserved region
DA376_RS00340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DA376_RS00350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA376_RS00355	COG2002	toxin-antitoxin pair type II binding
DA376_RS00360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA376_RS00360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA376_RS00365	COG0084	hydrolase, TatD family'
DA376_RS00370	COG3583	domain protein
DA376_RS00370	COG3584	3D domain protein
DA376_RS00375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DA376_RS00380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA376_RS00390	COG4466	Protein conserved in bacteria
DA376_RS00405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DA376_RS00410	COG0251	oxidation-reduction process
DA376_RS00425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA376_RS00445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DA376_RS00450	COG2002	toxin-antitoxin pair type II binding
DA376_RS00455	COG2244	polysaccharide biosynthetic process
DA376_RS00460	COG3956	TIGRFAM MazG family protein
DA376_RS00465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DA376_RS00480	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA376_RS00485	COG1098	S1 RNA binding domain
DA376_RS00500	COG2208	phosphoserine phosphatase activity
DA376_RS00505	COG2304	oxidoreductase activity
DA376_RS00510	COG0515	serine threonine protein kinase
DA376_RS00515	COG0037	tRNA processing
DA376_RS00520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DA376_RS00525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA376_RS00540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA376_RS00545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA376_RS00550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA376_RS00555	COG0512	Glutamine amidotransferase of anthranilate synthase
DA376_RS00560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA376_RS00565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA376_RS00570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA376_RS00575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA376_RS00580	COG1396	sequence-specific DNA binding
DA376_RS00585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA376_RS00590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DA376_RS00670	COG4463	regulation of RNA biosynthetic process
DA376_RS00675	COG3880	PFAM UvrB UvrC protein
DA376_RS00685	COG0542	response to heat
DA376_RS00690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DA376_RS00695	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DA376_RS00700	COG4956	integral membrane protein (PIN domain superfamily)
DA376_RS00720	COG1045	serine acetyltransferase
DA376_RS00730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DA376_RS00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA376_RS00740	COG3688	RNA-binding protein containing a PIN domain
DA376_RS00745	COG1595	DNA-templated transcription, initiation
DA376_RS00755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA376_RS00760	COG0250	Participates in transcription elongation, termination and antitermination
DA376_RS00785	COG2813	Specifically methylates the guanine in position
DA376_RS00800	COG1358	cellular component organization or biogenesis
DA376_RS00825	COG0596	Alpha beta hydrolase
DA376_RS00920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DA376_RS00935	COG0201	protein transport
DA376_RS00945	COG0024	Methionine aminopeptidase
DA376_RS00960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DA376_RS00985	COG1122	ATPase activity
DA376_RS00990	COG1122	ATPase activity
DA376_RS00995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DA376_RS01015	COG2226	methyltransferase
DA376_RS01020	COG2318	DinB family
DA376_RS01030	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS01035	COG0489	protein tyrosine kinase activity
DA376_RS01045	COG2194	sulfuric ester hydrolase activity
DA376_RS01050	COG0726	polysaccharide deacetylase
DA376_RS01110	COG0738	Major facilitator superfamily
DA376_RS01115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA376_RS01125	COG1063	alcohol dehydrogenase
DA376_RS01130	COG0659	secondary active sulfate transmembrane transporter activity
DA376_RS01135	COG0385	Bile acid
DA376_RS01140	COG2819	hydrolase of the alpha beta superfamily
DA376_RS01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS01150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS01155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA376_RS01160	COG2207	Transcriptional regulator
DA376_RS01160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA376_RS01165	COG3876	Protein conserved in bacteria
DA376_RS01170	COG1472	Belongs to the glycosyl hydrolase 3 family
DA376_RS01175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA376_RS01180	COG1263	PTS System
DA376_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS01190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA376_RS01195	COG1683	Conserved Protein
DA376_RS01225	COG1595	DNA-templated transcription, initiation
DA376_RS01230	COG5662	AntiSigma factor
DA376_RS01235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DA376_RS01240	COG4856	YbbR-like protein
DA376_RS01275	COG5002	protein histidine kinase activity
DA376_RS01280	COG1136	(ABC) transporter
DA376_RS01285	COG0577	efflux transmembrane transporter activity
DA376_RS01305	COG1346	cytolysis
DA376_RS01310	COG1380	Effector of murein hydrolase LrgA
DA376_RS01315	COG1846	Transcriptional regulator
DA376_RS01320	COG1113	amino acid transport
DA376_RS01325	COG1011	Hydrolase
DA376_RS01330	COG4585	Histidine kinase
DA376_RS01335	COG2197	response regulator
DA376_RS01340	COG1131	(ABC) transporter
DA376_RS01380	COG0531	amino acid
DA376_RS01385	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DA376_RS01400	COG0584	glycerophosphoryl diester phosphodiesterase
DA376_RS01405	COG2271	Major facilitator Superfamily
DA376_RS01420	COG2368	4-hydroxyphenylacetate
DA376_RS01430	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS01445	COG1397	ADP-ribosylglycohydrolase
DA376_RS01450	COG5444	nuclease activity
DA376_RS01460	COG0371	Dehydrogenase
DA376_RS01470	COG1183	phosphatidylcholine synthase activity
DA376_RS01475	COG0586	Pfam SNARE associated Golgi protein
DA376_RS01480	COG0688	phosphatidylethanolamine metabolic process
DA376_RS01495	COG1301	dicarboxylic acid transport
DA376_RS01500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA376_RS01505	COG0833	amino acid
DA376_RS01510	COG2040	homocysteine
DA376_RS01515	COG1115	amino acid carrier protein
DA376_RS01520	COG2066	Belongs to the glutaminase family
DA376_RS01525	COG4191	Histidine kinase
DA376_RS01530	COG0784	Response regulator, receiver
DA376_RS01535	COG3173	Aminoglycoside phosphotransferase
DA376_RS01550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA376_RS01555	COG0778	Nitroreductase
DA376_RS01560	COG0346	lactoylglutathione lyase activity
DA376_RS01565	COG2259	Doxx family
DA376_RS01570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS01590	COG3773	Cell wall hydrolase
DA376_RS01600	COG3540	Alkaline phosphatase
DA376_RS01605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA376_RS01610	COG0805	protein transport
DA376_RS01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA376_RS01625	COG0477	Major facilitator Superfamily
DA376_RS01630	COG1309	transcriptional regulator
DA376_RS01635	COG0252	asparaginase activity
DA376_RS01640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DA376_RS01645	COG1405	negative regulation of cell septum assembly
DA376_RS01645	COG3012	SEC-C Motif Domain Protein
DA376_RS01660	COG1595	DNA-templated transcription, initiation
DA376_RS01665	COG1595	DNA-templated transcription, initiation
DA376_RS01670	COG1876	peptidase activity
DA376_RS01675	COG0457	Tetratricopeptide repeat
DA376_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS01685	COG0366	Alpha amylase catalytic
DA376_RS01690	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA376_RS01695	COG1121	(ABC) transporter
DA376_RS01700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA376_RS01705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS01710	COG2310	stress, protein
DA376_RS01715	COG2310	stress, protein
DA376_RS01720	COG2310	stress, protein
DA376_RS01725	COG0861	Integral membrane protein TerC family
DA376_RS01735	COG3853	Toxic anion resistance protein (TelA)
DA376_RS01740	COG0477	Major facilitator Superfamily
DA376_RS01745	COG4175	Glycine betaine
DA376_RS01745	COG0517	IMP dehydrogenase activity
DA376_RS01750	COG4176	ABC-type proline glycine betaine transport system permease component
DA376_RS01755	COG2113	Glycine betaine
DA376_RS01760	COG1473	amidohydrolase
DA376_RS01765	COG1288	antiporter activity
DA376_RS01785	COG2814	Major facilitator Superfamily
DA376_RS01790	COG1846	Transcriptional regulator
DA376_RS01795	COG1280	lysine exporter protein (LysE YggA)
DA376_RS01800	COG3403	YqcI/YcgG family
DA376_RS01805	COG1113	amino acid transport
DA376_RS01810	COG3665	Urea carboxylase-associated protein
DA376_RS01825	COG1660	Displays ATPase and GTPase activities
DA376_RS01830	COG1082	Xylose isomerase domain protein TIM barrel
DA376_RS01835	COG2271	Major facilitator Superfamily
DA376_RS01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA376_RS01845	COG3458	cephalosporin-C deacetylase activity
DA376_RS01850	COG3541	Predicted nucleotidyltransferase
DA376_RS01855	COG0506	proline dehydrogenase activity
DA376_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA376_RS01870	COG2508	Transcriptional regulator
DA376_RS01880	COG1587	Uroporphyrinogen-III synthase
DA376_RS01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA376_RS01885	COG2146	nitrite reductase [NAD(P)H] activity
DA376_RS01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA376_RS01895	COG0243	molybdopterin cofactor binding
DA376_RS01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA376_RS01905	COG2223	nitrite transmembrane transporter activity
DA376_RS01910	COG0523	cobalamin synthesis protein
DA376_RS01915	COG1063	alcohol dehydrogenase
DA376_RS01920	COG1714	RDD family
DA376_RS01930	COG2723	6-phospho-beta-galactosidase activity
DA376_RS01945	COG3209	COG3209 Rhs family protein
DA376_RS01950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DA376_RS01955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DA376_RS01960	COG1733	regulation of RNA biosynthetic process
DA376_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DA376_RS02000	COG2364	Membrane
DA376_RS02005	COG1126	abc transporter atp-binding protein
DA376_RS02010	COG0765	amino acid transport
DA376_RS02020	COG0583	DNA-binding transcription factor activity
DA376_RS02025	COG0163	prenyltransferase activity
DA376_RS02030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DA376_RS02045	COG3104	oligopeptide transport
DA376_RS02050	COG5434	Belongs to the glycosyl hydrolase 28 family
DA376_RS02060	COG0697	spore germination
DA376_RS02070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA376_RS02075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS02080	COG0456	acetyltransferase
DA376_RS02085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA376_RS02090	COG0765	amino acid transport
DA376_RS02095	COG1126	abc transporter atp-binding protein
DA376_RS02100	COG1473	amidohydrolase
DA376_RS02105	COG2079	MmgE PrpD family protein
DA376_RS02110	COG1136	(ABC) transporter
DA376_RS02115	COG0577	efflux transmembrane transporter activity
DA376_RS02120	COG0745	RESPONSE REGULATOR receiver
DA376_RS02125	COG3850	Histidine kinase
DA376_RS02125	COG5002	protein histidine kinase activity
DA376_RS02130	COG0457	Tetratricopeptide repeat
DA376_RS02145	COG0527	aspartate kinase activity
DA376_RS02150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS02155	COG4605	iron ion homeostasis
DA376_RS02160	COG4604	ABC transporter, ATP-binding protein
DA376_RS02165	COG4607	ABC-type enterochelin transport system periplasmic component
DA376_RS02170	COG2814	Major facilitator Superfamily
DA376_RS02175	COG1309	transcriptional regulator
DA376_RS02180	COG0778	Nitroreductase
DA376_RS02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA376_RS02190	COG0640	Transcriptional regulator
DA376_RS02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA376_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS02210	COG4975	Glucose uptake
DA376_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS02220	COG4549	nuclear export factor GLE1
DA376_RS02225	COG1276	copper resistance
DA376_RS02225	COG2372	response to copper ion
DA376_RS02230	COG1349	DNA-binding transcription factor activity
DA376_RS02240	COG2213	PTS system mannitol-specific
DA376_RS02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS02255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA376_RS02265	COG0561	phosphatase activity
DA376_RS02275	COG1914	H( )-stimulated, divalent metal cation uptake system
DA376_RS02285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DA376_RS02290	COG1984	allophanate hydrolase subunit 2
DA376_RS02295	COG1414	Transcriptional regulator
DA376_RS02300	COG2755	lipolytic protein G-D-S-L family
DA376_RS02310	COG2329	Antibiotic biosynthesis monooxygenase
DA376_RS02315	COG0768	penicillin binding
DA376_RS02320	COG4989	oxidoreductase activity
DA376_RS02325	COG3711	transcriptional antiterminator
DA376_RS02330	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS02340	COG1917	Cupin 2, conserved barrel domain protein
DA376_RS02345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA376_RS02350	COG3871	stress protein (general stress protein 26)
DA376_RS02360	COG2814	Major facilitator Superfamily
DA376_RS02365	COG1522	sequence-specific DNA binding
DA376_RS02370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA376_RS02370	COG0551	DNA topoisomerase type I activity
DA376_RS02375	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DA376_RS02380	COG3706	GGDEF domain
DA376_RS02385	COG5298	Protein conserved in bacteria
DA376_RS02390	COG1215	transferase activity, transferring glycosyl groups
DA376_RS02400	COG0531	amino acid
DA376_RS02410	COG0028	Belongs to the TPP enzyme family
DA376_RS02440	COG0457	Tetratricopeptide repeat
DA376_RS02470	COG1914	H( )-stimulated, divalent metal cation uptake system
DA376_RS02485	COG4876	unkown
DA376_RS02495	COG2076	Multidrug Resistance protein
DA376_RS02500	COG2217	Heavy metal translocating P-type atpase
DA376_RS02505	COG3729	General stress protein
DA376_RS02510	COG0662	Cupin 2, conserved barrel domain protein
DA376_RS02515	COG2329	Antibiotic biosynthesis monooxygenase
DA376_RS02520	COG3546	catalase activity
DA376_RS02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DA376_RS02530	COG3290	protein histidine kinase activity
DA376_RS02535	COG4565	transcriptional regulatory protein
DA376_RS02540	COG1301	dicarboxylic acid transport
DA376_RS02545	COG0628	permease
DA376_RS02550	COG1131	(ABC) transporter
DA376_RS02555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA376_RS02565	COG1960	acyl-CoA dehydrogenase activity
DA376_RS02580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA376_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS02595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DA376_RS02600	COG0513	Belongs to the DEAD box helicase family
DA376_RS02605	COG3402	PFAM membrane-flanked domain
DA376_RS02610	COG3428	Bacterial PH domain
DA376_RS02615	COG0705	Rhomboid family
DA376_RS02625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DA376_RS02630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA376_RS02635	COG0864	Transcriptional regulator
DA376_RS02640	COG2337	Toxic component of a toxin-antitoxin (TA) module
DA376_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS02655	COG2172	sigma factor antagonist activity
DA376_RS02660	COG2208	phosphoserine phosphatase activity
DA376_RS02665	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS02675	COG1191	sigma factor activity
DA376_RS02680	COG2208	phosphoserine phosphatase activity
DA376_RS02685	COG2183	response to ionizing radiation
DA376_RS02755	COG5444	nuclease activity
DA376_RS02760	COG0457	Tetratricopeptide repeat
DA376_RS02775	COG0477	Major facilitator Superfamily
DA376_RS02780	COG1846	Transcriptional regulator
DA376_RS02790	COG2030	dehydratase
DA376_RS02805	COG1959	2 iron, 2 sulfur cluster binding
DA376_RS02810	COG2910	NAD(P)H-binding
DA376_RS02825	COG1278	Cold shock
DA376_RS02830	COG1329	Transcriptional regulator
DA376_RS02835	COG1937	Protein conserved in bacteria
DA376_RS02840	COG2210	Belongs to the sulfur carrier protein TusA family
DA376_RS02845	COG1054	Belongs to the UPF0176 family
DA376_RS02850	COG0425	Belongs to the sulfur carrier protein TusA family
DA376_RS02850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA376_RS02855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA376_RS02855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS02860	COG0425	Belongs to the sulfur carrier protein TusA family
DA376_RS02865	COG0730	response to heat
DA376_RS02870	COG1794	racemase activity, acting on amino acids and derivatives
DA376_RS02885	COG3621	Patatin-like phospholipase
DA376_RS02895	COG0662	Cupin 2, conserved barrel domain protein
DA376_RS02910	COG0277	FAD linked oxidase domain protein
DA376_RS02935	COG0662	Cupin 2, conserved barrel domain protein
DA376_RS02940	COG2318	DinB family
DA376_RS02975	COG1064	alcohol dehydrogenase
DA376_RS02980	COG0789	Transcriptional regulator
DA376_RS02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS03005	COG2814	Major facilitator Superfamily
DA376_RS03010	COG1309	transcriptional regulator
DA376_RS03015	COG0697	spore germination
DA376_RS03020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS03025	COG5577	PFAM Coat F domain
DA376_RS03035	COG1063	alcohol dehydrogenase
DA376_RS03040	COG5577	PFAM Coat F domain
DA376_RS03050	COG4585	Histidine kinase
DA376_RS03055	COG2197	response regulator
DA376_RS03060	COG2409	Drug exporters of the RND superfamily
DA376_RS03065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA376_RS03070	COG0488	(ABC) transporter
DA376_RS03075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA376_RS03080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS03090	COG2814	Major facilitator Superfamily
DA376_RS03095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA376_RS03105	COG0730	response to heat
DA376_RS03110	COG0456	acetyltransferase
DA376_RS03115	COG0789	Transcriptional regulator
DA376_RS03115	COG4978	Transcriptional regulator
DA376_RS03120	COG0697	spore germination
DA376_RS03125	COG1051	belongs to the nudix hydrolase family
DA376_RS03130	COG2226	methyltransferase
DA376_RS03135	COG0473	3-isopropylmalate dehydrogenase activity
DA376_RS03140	COG1802	Transcriptional regulator
DA376_RS03145	COG1819	glycosyl
DA376_RS03160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA376_RS03165	COG1388	LysM domain
DA376_RS03170	COG2814	Major facilitator Superfamily
DA376_RS03175	COG2188	Transcriptional regulator
DA376_RS03180	COG2186	Transcriptional regulator
DA376_RS03185	COG2807	transmembrane transport
DA376_RS03190	COG2076	Multidrug Resistance protein
DA376_RS03195	COG2076	Multidrug Resistance protein
DA376_RS03200	COG1309	transcriptional regulator
DA376_RS03205	COG0531	amino acid
DA376_RS03215	COG3832	glyoxalase III activity
DA376_RS03220	COG0604	alcohol dehydrogenase
DA376_RS03225	COG2814	Major facilitator Superfamily
DA376_RS03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DA376_RS03270	COG0802	atpase or kinase
DA376_RS03275	COG1214	PFAM Peptidase M22, glycoprotease
DA376_RS03280	COG0456	acetyltransferase
DA376_RS03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DA376_RS03290	COG0488	(ABC) transporter
DA376_RS03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA376_RS03310	COG0805	protein transport
DA376_RS03320	COG1266	CAAX protease self-immunity
DA376_RS03360	COG0457	Tetratricopeptide repeat
DA376_RS03365	COG1063	alcohol dehydrogenase
DA376_RS03370	COG2211	Major facilitator Superfamily
DA376_RS03375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA376_RS03385	COG1842	Phage shock protein A
DA376_RS03390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA376_RS03395	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DA376_RS03400	COG4260	virion core protein, lumpy skin disease virus
DA376_RS03405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DA376_RS03405	COG2755	lipolytic protein G-D-S-L family
DA376_RS03415	COG1595	DNA-templated transcription, initiation
DA376_RS03420	COG1063	alcohol dehydrogenase
DA376_RS03425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA376_RS03430	COG0823	Involved in the tonB-independent uptake of proteins
DA376_RS03440	COG2132	Multicopper oxidase
DA376_RS03445	COG1113	amino acid transport
DA376_RS03450	COG0714	Associated with various cellular activities
DA376_RS03455	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DA376_RS03460	COG1305	Transglutaminase-like
DA376_RS03485	COG2252	PERMEase
DA376_RS03490	COG3064	Membrane
DA376_RS03510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DA376_RS03515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DA376_RS03520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA376_RS03525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DA376_RS03530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA376_RS03545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA376_RS03555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA376_RS03560	COG0138	bifunctional purine biosynthesis protein purh
DA376_RS03565	COG0151	Belongs to the GarS family
DA376_RS03575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DA376_RS03580	COG1470	cell adhesion involved in biofilm formation
DA376_RS03585	COG4496	protein, YerC YecD
DA376_RS03590	COG0069	glutamate synthase activity
DA376_RS03605	COG0210	DNA helicase
DA376_RS03615	COG4851	CamS sex pheromone cAM373 precursor
DA376_RS03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA376_RS03625	COG1285	pathogenesis
DA376_RS03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA376_RS03650	COG1309	transcriptional regulator
DA376_RS03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA376_RS03660	COG1597	lipid kinase activity
DA376_RS03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA376_RS03675	COG1131	(ABC) transporter
DA376_RS03715	COG5444	nuclease activity
DA376_RS03745	COG3546	catalase activity
DA376_RS03750	COG0454	-acetyltransferase
DA376_RS03760	COG2323	membrane
DA376_RS03765	COG2329	Antibiotic biosynthesis monooxygenase
DA376_RS03770	COG0346	lactoylglutathione lyase activity
DA376_RS03775	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS03780	COG5583	Uncharacterized small protein (DUF2292)
DA376_RS03785	COG0196	riboflavin kinase activity
DA376_RS03790	COG0670	Belongs to the BI1 family
DA376_RS03795	COG1846	Transcriptional regulator
DA376_RS03800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA376_RS03810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA376_RS03810	COG2124	cytochrome p450
DA376_RS03815	COG1368	sulfuric ester hydrolase activity
DA376_RS03820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA376_RS03825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS03830	COG1442	glycosyl transferase family 8
DA376_RS03835	COG1216	Glycosyl transferase, family 2
DA376_RS03840	COG1442	glycosyl transferase family 8
DA376_RS03845	COG2223	nitrite transmembrane transporter activity
DA376_RS03850	COG0531	amino acid
DA376_RS03855	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS03860	COG0840	transmembrane signaling receptor activity
DA376_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS03870	COG0463	Glycosyl transferase, family 2
DA376_RS03870	COG0457	Tetratricopeptide repeat
DA376_RS03875	COG0488	(ABC) transporter
DA376_RS03880	COG0789	Transcriptional regulator
DA376_RS03885	COG2814	Major facilitator Superfamily
DA376_RS03890	COG0488	(ABC) transporter
DA376_RS03895	COG0513	Belongs to the DEAD box helicase family
DA376_RS03900	COG0456	acetyltransferase
DA376_RS03905	COG2130	NADP-dependent
DA376_RS03920	COG3866	Pectate lyase
DA376_RS03925	COG0471	metal ion transport
DA376_RS03945	COG3290	protein histidine kinase activity
DA376_RS03950	COG4565	transcriptional regulatory protein
DA376_RS03955	COG3181	Tripartite tricarboxylate transporter family receptor
DA376_RS03960	COG2851	Citrate transporter
DA376_RS03965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS03970	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DA376_RS03980	COG2258	MOSC domain
DA376_RS04000	COG0024	Methionine aminopeptidase
DA376_RS04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS04005	COG1263	PTS System
DA376_RS04015	COG1368	sulfuric ester hydrolase activity
DA376_RS04025	COG0071	Belongs to the small heat shock protein (HSP20) family
DA376_RS04040	COG1263	PTS System
DA376_RS04040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS04045	COG0366	Alpha amylase catalytic
DA376_RS04050	COG2188	Transcriptional regulator
DA376_RS04055	COG0778	Nitroreductase
DA376_RS04070	COG0737	Belongs to the 5'-nucleotidase family
DA376_RS04075	COG0693	protein deglycase activity
DA376_RS04080	COG1609	Transcriptional regulator
DA376_RS04095	COG2814	Major facilitator Superfamily
DA376_RS04105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA376_RS04110	COG4980	gas vesicle protein
DA376_RS04115	COG1295	ribonuclease BN
DA376_RS04120	COG0477	Major facilitator Superfamily
DA376_RS04125	COG0387	Pfam Sodium calcium exchanger
DA376_RS04135	COG0668	transmembrane transport
DA376_RS04140	COG0535	radical SAM domain protein
DA376_RS04150	COG0726	polysaccharide deacetylase
DA376_RS04170	COG0745	RESPONSE REGULATOR receiver
DA376_RS04175	COG2205	protein histidine kinase activity
DA376_RS04180	COG2084	Dehydrogenase
DA376_RS04190	COG0598	Magnesium transport protein CorA
DA376_RS04195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DA376_RS04200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA376_RS04215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA376_RS04220	COG4637	Psort location Cytoplasmic, score
DA376_RS04225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA376_RS04230	COG0022	dehydrogenase e1 component
DA376_RS04235	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA376_RS04240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA376_RS04245	COG3284	Transcriptional regulator
DA376_RS04255	COG1486	melibiose metabolic process
DA376_RS04260	COG1737	Transcriptional regulator
DA376_RS04265	COG1263	PTS System
DA376_RS04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS04275	COG1132	(ABC) transporter
DA376_RS04280	COG1132	(ABC) transporter
DA376_RS04285	COG2259	Doxx family
DA376_RS04290	COG2514	catechol 2,3-dioxygenase activity
DA376_RS04300	COG1695	Transcriptional regulator
DA376_RS04305	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA376_RS04310	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DA376_RS04315	COG0574	Belongs to the PEP-utilizing enzyme family
DA376_RS04315	COG3848	Pyruvate phosphate dikinase
DA376_RS04320	COG2732	(Barnase) inhibitor
DA376_RS04325	COG2318	DinB family
DA376_RS04330	COG2814	Major facilitator Superfamily
DA376_RS04335	COG1846	Transcriptional regulator
DA376_RS04340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DA376_RS04340	COG0392	lysyltransferase activity
DA376_RS04345	COG0384	phenazine biosynthesis protein PhzF
DA376_RS04350	COG0778	Nitroreductase
DA376_RS04365	COG1090	epimerase
DA376_RS04380	COG2814	Major facilitator Superfamily
DA376_RS04390	COG3591	Belongs to the peptidase S1B family
DA376_RS04405	COG3103	Sh3 type 3 domain protein
DA376_RS04410	COG5658	integral membrane protein
DA376_RS04415	COG0596	Alpha beta hydrolase
DA376_RS04420	COG0463	Glycosyl transferase, family 2
DA376_RS04425	COG4485	Bacterial membrane protein, YfhO
DA376_RS04430	COG1988	membrane-bound metal-dependent
DA376_RS04435	COG1194	a g-specific adenine glycosylase
DA376_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS04465	COG1132	(ABC) transporter
DA376_RS04470	COG4129	membrane
DA376_RS04480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DA376_RS04485	COG0735	belongs to the Fur family
DA376_RS04600	COG3340	Belongs to the peptidase S51 family
DA376_RS04610	COG0277	FAD linked oxidase domain protein
DA376_RS04620	COG0747	negative chemotaxis
DA376_RS04625	COG0601	transmembrane transport
DA376_RS04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA376_RS04635	COG0444	Belongs to the ABC transporter superfamily
DA376_RS04640	COG4608	Belongs to the ABC transporter superfamily
DA376_RS04645	COG0753	catalase activity
DA376_RS04655	COG1116	anion transmembrane transporter activity
DA376_RS04660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA376_RS04665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA376_RS04685	COG1476	TRANSCRIPTIONal
DA376_RS04695	COG3382	B3 4 domain protein
DA376_RS04700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DA376_RS04710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA376_RS04715	COG0789	Transcriptional regulator
DA376_RS04720	COG1664	Polymer-forming cytoskeletal
DA376_RS04725	COG1664	Polymer-forming cytoskeletal
DA376_RS04735	COG2766	serine protein kinase
DA376_RS04750	COG1846	Transcriptional regulator
DA376_RS04755	COG1566	PFAM secretion protein HlyD family protein
DA376_RS04760	COG2814	Major facilitator Superfamily
DA376_RS04765	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA376_RS04780	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA376_RS04785	COG1278	Cold shock
DA376_RS04795	COG1464	Belongs to the NlpA lipoprotein family
DA376_RS04800	COG3706	GGDEF domain
DA376_RS04805	COG1823	symporter activity
DA376_RS04825	COG5577	PFAM Coat F domain
DA376_RS04830	COG1525	nuclease
DA376_RS04830	COG4085	toxin activity
DA376_RS04830	COG0737	Belongs to the 5'-nucleotidase family
DA376_RS04835	COG3764	Sortase (surface protein transpeptidase)
DA376_RS04840	COG0564	pseudouridine synthase activity
DA376_RS04850	COG0517	IMP dehydrogenase activity
DA376_RS04855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA376_RS04860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA376_RS04860	COG3153	acetyltransferase
DA376_RS04865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA376_RS04870	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DA376_RS04875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA376_RS04885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA376_RS04890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA376_RS04895	COG4585	Histidine kinase
DA376_RS04895	COG2203	Gaf domain
DA376_RS04900	COG2197	response regulator
DA376_RS04905	COG0431	NADPH-dependent FMN reductase
DA376_RS04920	COG1388	LysM domain
DA376_RS04920	COG0791	NLP P60 protein
DA376_RS04925	COG1959	2 iron, 2 sulfur cluster binding
DA376_RS04935	COG0668	transmembrane transport
DA376_RS04940	COG2719	SpoVR family
DA376_RS04945	COG1785	Belongs to the alkaline phosphatase family
DA376_RS04950	COG1388	LysM domain
DA376_RS04950	COG0791	NLP P60 protein
DA376_RS04955	COG0583	DNA-binding transcription factor activity
DA376_RS04960	COG0372	Belongs to the citrate synthase family
DA376_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS04970	COG0531	amino acid
DA376_RS04975	COG0733	neurotransmitter:sodium symporter activity
DA376_RS04990	COG1595	DNA-templated transcription, initiation
DA376_RS04995	COG0204	Acyl-transferase
DA376_RS05000	COG1253	flavin adenine dinucleotide binding
DA376_RS05005	COG0789	Transcriptional regulator
DA376_RS05010	COG0436	Aminotransferase
DA376_RS05015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA376_RS05020	COG1253	flavin adenine dinucleotide binding
DA376_RS05025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA376_RS05030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA376_RS05035	COG0584	glycerophosphoryl diester phosphodiesterase
DA376_RS05045	COG0668	transmembrane transport
DA376_RS05050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DA376_RS05055	COG0726	polysaccharide deacetylase
DA376_RS05060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA376_RS05065	COG3226	Transcriptional regulator
DA376_RS05075	COG0589	response to stress
DA376_RS05080	COG1132	(ABC) transporter
DA376_RS05085	COG1132	(ABC) transporter
DA376_RS05090	COG0702	epimerase
DA376_RS05110	COG0189	ligase activity
DA376_RS05115	COG0189	ligase activity
DA376_RS05130	COG4335	DNA alkylation repair
DA376_RS05135	COG0561	phosphatase activity
DA376_RS05140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA376_RS05150	COG0475	glutathione-regulated potassium exporter activity
DA376_RS05155	COG0490	domain, Protein
DA376_RS05165	COG1024	Enoyl-CoA hydratase
DA376_RS05175	COG4152	abc transporter atp-binding protein
DA376_RS05180	COG1668	transmembrane transport
DA376_RS05185	COG0420	3'-5' exonuclease activity
DA376_RS05190	COG4717	serine-type aminopeptidase activity
DA376_RS05205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA376_RS05245	COG4980	gas vesicle protein
DA376_RS05260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DA376_RS05265	COG0537	adenosine 5'-monophosphoramidase activity
DA376_RS05270	COG1131	(ABC) transporter
DA376_RS05275	COG4473	ABC transporter
DA376_RS05285	COG1473	amidohydrolase
DA376_RS05290	COG3069	C4-dicarboxylate transmembrane transporter activity
DA376_RS05295	COG2329	Antibiotic biosynthesis monooxygenase
DA376_RS05300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA376_RS05310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DA376_RS05315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DA376_RS05320	COG1309	transcriptional regulator
DA376_RS05325	COG1511	domain protein
DA376_RS05330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA376_RS05340	COG1363	Peptidase, m42
DA376_RS05345	COG1301	dicarboxylic acid transport
DA376_RS05355	COG1234	tRNA 3'-trailer cleavage
DA376_RS05360	COG0095	Lipoate-protein ligase
DA376_RS05365	COG0702	epimerase
DA376_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS05380	COG0501	Belongs to the peptidase M48B family
DA376_RS05385	COG1404	Belongs to the peptidase S8 family
DA376_RS05395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DA376_RS05400	COG0406	alpha-ribazole phosphatase activity
DA376_RS05405	COG0183	Belongs to the thiolase family
DA376_RS05410	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS05415	COG1268	BioY protein
DA376_RS05420	COG0840	transmembrane signaling receptor activity
DA376_RS05425	COG0723	plastoquinol--plastocyanin reductase activity
DA376_RS05425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA376_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS05440	COG4903	ComK protein
DA376_RS05450	COG5646	InterPro IPR014922
DA376_RS05470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA376_RS05485	COG0398	Pfam SNARE associated Golgi protein
DA376_RS05490	COG0681	Belongs to the peptidase S26 family
DA376_RS05495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA376_RS05500	COG1846	Transcriptional regulator
DA376_RS05505	COG3180	Ammonia monooxygenase
DA376_RS05510	COG2814	Major facilitator Superfamily
DA376_RS05520	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DA376_RS05525	COG2323	membrane
DA376_RS05540	COG0420	3'-5' exonuclease activity
DA376_RS05545	COG0419	ATPase involved in DNA repair
DA376_RS05550	COG1403	HNH endonuclease
DA376_RS05590	COG0179	Fumarylacetoacetate (FAA) hydrolase
DA376_RS05610	COG0367	asparagine synthase
DA376_RS05615	COG1562	ergosterol biosynthetic process
DA376_RS05620	COG0534	Mate efflux family protein
DA376_RS05625	COG1917	Cupin 2, conserved barrel domain protein
DA376_RS05625	COG2207	Transcriptional regulator
DA376_RS05635	COG2318	DinB family
DA376_RS05640	COG1279	arginine transmembrane transporter activity
DA376_RS05645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS05650	COG1357	PFAM Pentapeptide repeats (8 copies)
DA376_RS05655	COG2153	protein acetylation
DA376_RS05660	COG0646	methionine synthase
DA376_RS05660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DA376_RS05670	COG2996	Protein conserved in bacteria
DA376_RS05675	COG1744	ABC transporter substrate-binding protein PnrA-like
DA376_RS05680	COG0840	transmembrane signaling receptor activity
DA376_RS05685	COG2124	cytochrome p450
DA376_RS05695	COG1307	EDD domain protein, DegV family
DA376_RS05700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS05715	COG0561	phosphatase activity
DA376_RS05720	COG1073	alpha beta
DA376_RS05725	COG2151	metal-sulfur cluster biosynthetic enzyme
DA376_RS05735	COG0277	FAD linked oxidase domain protein
DA376_RS05740	COG2271	Major facilitator Superfamily
DA376_RS05750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DA376_RS05760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA376_RS05765	COG0505	Belongs to the CarA family
DA376_RS05770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA376_RS05775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DA376_RS05795	COG2267	carboxylic ester hydrolase activity
DA376_RS05805	COG1744	ABC transporter substrate-binding protein PnrA-like
DA376_RS05820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA376_RS05825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA376_RS05830	COG5504	Zn-dependent protease
DA376_RS05835	COG0444	Belongs to the ABC transporter superfamily
DA376_RS05840	COG4608	Belongs to the ABC transporter superfamily
DA376_RS05850	COG0601	transmembrane transport
DA376_RS05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA376_RS05865	COG0180	Tryptophanyl-tRNA synthetase
DA376_RS05870	COG4166	transmembrane transport
DA376_RS05875	COG0601	transmembrane transport
DA376_RS05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA376_RS05885	COG0444	Belongs to the ABC transporter superfamily
DA376_RS05890	COG4608	Belongs to the ABC transporter superfamily
DA376_RS05900	COG0456	acetyltransferase
DA376_RS05905	COG1393	Belongs to the ArsC family
DA376_RS05910	COG0861	Integral membrane protein TerC family
DA376_RS05915	COG4862	establishment of competence for transformation
DA376_RS05920	COG4469	Competence protein
DA376_RS05925	COG1164	Oligoendopeptidase f
DA376_RS05930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DA376_RS05935	COG2346	COG2346, Truncated hemoglobins
DA376_RS05940	COG0741	lytic transglycosylase activity
DA376_RS05945	COG4116	CYTH
DA376_RS05955	COG2357	RelA SpoT domain protein
DA376_RS05960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA376_RS05965	COG0564	pseudouridine synthase activity
DA376_RS05980	COG0569	domain protein
DA376_RS05980	COG0475	glutathione-regulated potassium exporter activity
DA376_RS05985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DA376_RS05990	COG0352	thiamine-phosphate diphosphorylase activity
DA376_RS05995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA376_RS06000	COG2104	thiamine diphosphate biosynthetic process
DA376_RS06010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA376_RS06015	COG0351	phosphomethylpyrimidine kinase
DA376_RS06020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA376_RS06075	COG0210	DNA helicase
DA376_RS06095	COG1131	(ABC) transporter
DA376_RS06105	COG2153	protein acetylation
DA376_RS06115	COG2382	esterase
DA376_RS06120	COG0626	cystathionine gamma-synthase activity
DA376_RS06125	COG0626	cystathionine gamma-synthase activity
DA376_RS06155	COG5444	nuclease activity
DA376_RS06165	COG0346	lactoylglutathione lyase activity
DA376_RS06170	COG2367	Beta-lactamase
DA376_RS06175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA376_RS06180	COG0477	Major facilitator Superfamily
DA376_RS06185	COG1846	Transcriptional regulator
DA376_RS06195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DA376_RS06200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA376_RS06205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA376_RS06210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS06210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS06215	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA376_RS06225	COG1349	DNA-binding transcription factor activity
DA376_RS06245	COG1285	pathogenesis
DA376_RS06260	COG2205	protein histidine kinase activity
DA376_RS06270	COG3383	formate dehydrogenase (NAD+) activity
DA376_RS06275	COG2427	Protein of unknown function (DUF1641)
DA376_RS06280	COG2124	cytochrome p450
DA376_RS06285	COG1819	glycosyl
DA376_RS06295	COG1587	Uroporphyrinogen-III synthase
DA376_RS06300	COG0390	transport system, permease component
DA376_RS06305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA376_RS06310	COG0697	spore germination
DA376_RS06315	COG4297	protein containing double-stranded beta helix domain
DA376_RS06325	COG1252	NADH dehydrogenase
DA376_RS06335	COG2211	Major facilitator Superfamily
DA376_RS06340	COG1609	Transcriptional regulator
DA376_RS06345	COG0246	Mannitol dehydrogenase
DA376_RS06350	COG2721	sulfolactate sulfo-lyase activity
DA376_RS06355	COG0745	RESPONSE REGULATOR receiver
DA376_RS06360	COG2770	Histidine kinase
DA376_RS06360	COG2205	protein histidine kinase activity
DA376_RS06380	COG4585	Histidine kinase
DA376_RS06385	COG2197	response regulator
DA376_RS06410	COG0730	response to heat
DA376_RS06415	COG2318	DinB family
DA376_RS06420	COG0457	Tetratricopeptide repeat
DA376_RS06425	COG5632	N-Acetylmuramoyl-L-alanine amidase
DA376_RS06425	COG1388	LysM domain
DA376_RS06425	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS06435	COG4195	phage-related replication protein
DA376_RS06440	COG2856	Zn peptidase
DA376_RS06445	COG1396	sequence-specific DNA binding
DA376_RS06455	COG1522	sequence-specific DNA binding
DA376_RS06460	COG1484	DNA-dependent DNA replication
DA376_RS06475	COG1595	DNA-templated transcription, initiation
DA376_RS06480	COG5484	DNA packaging
DA376_RS06480	COG3728	DNA packaging
DA376_RS06485	COG1783	phage Terminase large subunit
DA376_RS06490	COG5518	Phage portal protein
DA376_RS06495	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DA376_RS06500	COG4653	Phage capsid family
DA376_RS06550	COG5412	phage tail tape measure protein
DA376_RS06550	COG3953	SLT domain
DA376_RS06550	COG3953	SLT domain
DA376_RS06550	COG3953	SLT domain
DA376_RS06550	COG5412	phage tail tape measure protein
DA376_RS06550	COG5412	phage tail tape measure protein
DA376_RS06555	COG1652	LysM domain
DA376_RS06560	COG4193	domain, Protein
DA376_RS06570	COG3628	GPW Gp25 family protein
DA376_RS06575	COG3299	homolog of phage Mu protein gp47
DA376_RS06580	COG3778	Protein conserved in bacteria
DA376_RS06620	COG5632	N-Acetylmuramoyl-L-alanine amidase
DA376_RS06620	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS06635	COG0306	phosphate transporter
DA376_RS06640	COG1392	Phosphate transport regulator
DA376_RS06645	COG0531	amino acid
DA376_RS06650	COG0346	lactoylglutathione lyase activity
DA376_RS06655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA376_RS06660	COG0463	Glycosyl transferase, family 2
DA376_RS06665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA376_RS06670	COG0477	Major facilitator Superfamily
DA376_RS06675	COG2362	D-Aminopeptidase
DA376_RS06680	COG0601	transmembrane transport
DA376_RS06685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA376_RS06690	COG0444	Belongs to the ABC transporter superfamily
DA376_RS06695	COG4166	transmembrane transport
DA376_RS06700	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA376_RS06705	COG4948	Mandelate Racemase Muconate Lactonizing
DA376_RS06710	COG0791	NLP P60 protein
DA376_RS06715	COG4608	Belongs to the ABC transporter superfamily
DA376_RS06720	COG2706	6-phosphogluconolactonase activity
DA376_RS06725	COG1834	amidinotransferase
DA376_RS06730	COG1607	acyl-coa hydrolase
DA376_RS06735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA376_RS06740	COG2076	Multidrug Resistance protein
DA376_RS06745	COG2076	Multidrug Resistance protein
DA376_RS06750	COG0788	formyltetrahydrofolate deformylase activity
DA376_RS06755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA376_RS06765	COG1764	response to oxidative stress
DA376_RS06770	COG1846	Transcriptional regulator
DA376_RS06775	COG1764	response to oxidative stress
DA376_RS06790	COG0463	Glycosyl transferase, family 2
DA376_RS06790	COG0457	Tetratricopeptide repeat
DA376_RS06815	COG1404	Belongs to the peptidase S8 family
DA376_RS06820	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS06825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DA376_RS06830	COG1122	ATPase activity
DA376_RS06835	COG4721	ABC-type cobalt transport system, permease component
DA376_RS06840	COG3858	chitin binding
DA376_RS06840	COG1388	LysM domain
DA376_RS06860	COG2239	Acts as a magnesium transporter
DA376_RS06865	COG0789	Transcriptional regulator
DA376_RS06880	COG1846	Transcriptional regulator
DA376_RS06885	COG0726	polysaccharide deacetylase
DA376_RS06890	COG1793	dna ligase
DA376_RS06890	COG3285	dna ligase
DA376_RS06895	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DA376_RS06905	COG0586	Pfam SNARE associated Golgi protein
DA376_RS06910	COG0861	Integral membrane protein TerC family
DA376_RS06915	COG1191	sigma factor activity
DA376_RS06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA376_RS06945	COG2323	membrane
DA376_RS06955	COG3594	Acyltransferase
DA376_RS06960	COG5002	protein histidine kinase activity
DA376_RS06965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA376_RS06980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA376_RS06985	COG0436	Aminotransferase
DA376_RS07015	COG3852	Histidine kinase
DA376_RS07020	COG1846	Transcriptional regulator
DA376_RS07025	COG1360	Flagellar Motor Protein
DA376_RS07030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA376_RS07035	COG0542	response to heat
DA376_RS07045	COG3949	Membrane
DA376_RS07060	COG0720	synthase
DA376_RS07065	COG0602	queuosine metabolic process
DA376_RS07080	COG1733	regulation of RNA biosynthetic process
DA376_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS07100	COG4873	Protein conserved in bacteria
DA376_RS07110	COG3773	Cell wall hydrolase
DA376_RS07115	COG2244	polysaccharide biosynthetic process
DA376_RS07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS07125	COG2217	Heavy metal translocating P-type atpase
DA376_RS07130	COG0006	proline dipeptidase activity
DA376_RS07135	COG1609	Transcriptional regulator
DA376_RS07140	COG3711	transcriptional antiterminator
DA376_RS07145	COG2190	(PTS) system
DA376_RS07145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS07145	COG1263	PTS System
DA376_RS07150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS07155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA376_RS07165	COG1533	DNA photolyase activity
DA376_RS07170	COG0840	transmembrane signaling receptor activity
DA376_RS07175	COG2084	Dehydrogenase
DA376_RS07180	COG2340	Cysteine-rich secretory protein family
DA376_RS07185	COG0768	penicillin binding
DA376_RS07190	COG4191	Histidine kinase
DA376_RS07195	COG0436	Aminotransferase
DA376_RS07205	COG0784	Response regulator, receiver
DA376_RS07205	COG0835	chemotaxis
DA376_RS07215	COG2814	Major facilitator Superfamily
DA376_RS07220	COG1376	ErfK ybiS ycfS ynhG family protein
DA376_RS07225	COG1408	metallophosphoesterase
DA376_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS07240	COG2200	EAL domain
DA376_RS07245	COG4703	Protein of unknown function (DUF1797)
DA376_RS07250	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DA376_RS07260	COG0517	IMP dehydrogenase activity
DA376_RS07265	COG0583	DNA-binding transcription factor activity
DA376_RS07270	COG0716	FMN binding
DA376_RS07280	COG0716	FMN binding
DA376_RS07300	COG0668	transmembrane transport
DA376_RS07305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS07325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA376_RS07330	COG0303	'Molybdopterin
DA376_RS07335	COG1763	Mo-molybdopterin cofactor biosynthetic process
DA376_RS07340	COG0314	molybdopterin synthase activity
DA376_RS07345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DA376_RS07355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA376_RS07360	COG1136	(ABC) transporter
DA376_RS07365	COG0577	efflux transmembrane transporter activity
DA376_RS07370	COG1349	DNA-binding transcription factor activity
DA376_RS07375	COG1105	Belongs to the carbohydrate kinase PfkB family
DA376_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS07380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA376_RS07380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA376_RS07385	COG0681	Belongs to the peptidase S26 family
DA376_RS07395	COG0488	(ABC) transporter
DA376_RS07400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA376_RS07405	COG2309	aminopeptidase activity
DA376_RS07415	COG1077	Cell shape determining protein MreB Mrl
DA376_RS07425	COG2002	toxin-antitoxin pair type II binding
DA376_RS07430	COG3852	Histidine kinase
DA376_RS07435	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DA376_RS07435	COG2105	PFAM AIG2 family protein
DA376_RS07440	COG0569	domain protein
DA376_RS07450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DA376_RS07460	COG0561	phosphatase activity
DA376_RS07465	COG0242	peptide deformylase activity
DA376_RS07475	COG0497	DNA recombination
DA376_RS07485	COG2070	2-Nitropropane dioxygenase
DA376_RS07485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA376_RS07490	COG4221	oxidoreductase activity
DA376_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS07490	COG3321	synthase
DA376_RS07490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS07495	COG0300	oxidoreductase activity
DA376_RS07495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS07495	COG4221	oxidoreductase activity
DA376_RS07495	COG3321	synthase
DA376_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS07500	COG3321	synthase
DA376_RS07500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS07500	COG4221	oxidoreductase activity
DA376_RS07505	COG4221	oxidoreductase activity
DA376_RS07505	COG0300	oxidoreductase activity
DA376_RS07505	COG3321	synthase
DA376_RS07505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS07510	COG0300	oxidoreductase activity
DA376_RS07510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS07510	COG4221	oxidoreductase activity
DA376_RS07510	COG3321	synthase
DA376_RS07515	COG4221	oxidoreductase activity
DA376_RS07515	COG0300	oxidoreductase activity
DA376_RS07515	COG3321	synthase
DA376_RS07515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS07520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS07520	COG4221	oxidoreductase activity
DA376_RS07520	COG3321	synthase
DA376_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS07525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA376_RS07530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA376_RS07535	COG0022	dehydrogenase e1 component
DA376_RS07540	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA376_RS07545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA376_RS07550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS07565	COG1982	Orn Lys Arg decarboxylase major
DA376_RS07590	COG0483	inositol monophosphate 1-phosphatase activity
DA376_RS07600	COG3227	Zinc metalloprotease (Elastase)
DA376_RS07625	COG1217	gtp-binding protein TYPA
DA376_RS07635	COG4896	Protein conserved in bacteria
DA376_RS07645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DA376_RS07650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA376_RS07655	COG2066	Belongs to the glutaminase family
DA376_RS07665	COG0772	Belongs to the SEDS family
DA376_RS07670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DA376_RS07685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA376_RS07685	COG2010	Cytochrome c
DA376_RS07690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA376_RS07695	COG1845	cytochrome c oxidase, subunit III
DA376_RS07700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA376_RS07705	COG3336	cytochrome c oxidase
DA376_RS07715	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DA376_RS07720	COG2340	Cysteine-rich secretory protein family
DA376_RS07735	COG3679	Belongs to the UPF0342 family
DA376_RS07745	COG0742	ribosomal rna small subunit methyltransferase
DA376_RS07755	COG3314	Sporulation integral membrane protein YlbJ
DA376_RS07760	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA376_RS07765	COG3480	Lon protease (S16) C-terminal proteolytic domain
DA376_RS07775	COG1399	metal-binding, possibly nucleic acid-binding protein
DA376_RS07795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA376_RS07815	COG4839	cell division protein FtsL
DA376_RS07820	COG0768	penicillin binding
DA376_RS07825	COG0768	penicillin binding
DA376_RS07845	COG0772	Belongs to the SEDS family
DA376_RS07860	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA376_RS07865	COG0849	cell division
DA376_RS07870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA376_RS07875	COG4412	M6 family metalloprotease domain protein
DA376_RS07875	COG1404	Belongs to the peptidase S8 family
DA376_RS07885	COG1191	sigma factor activity
DA376_RS07890	COG1191	sigma factor activity
DA376_RS07895	COG1119	ATPase activity
DA376_RS07900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA376_RS07905	COG1873	PFAM PRC-barrel domain
DA376_RS07910	COG1496	oxidoreductase activity
DA376_RS07915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DA376_RS07925	COG0762	integral membrane protein
DA376_RS07930	COG2302	S4 RNA-binding domain
DA376_RS07935	COG3599	regulation of cell shape
DA376_RS07945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA376_RS07950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA376_RS07960	COG0564	pseudouridine synthase activity
DA376_RS07970	COG2233	PERMEase
DA376_RS07980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA376_RS07985	COG0505	Belongs to the CarA family
DA376_RS07990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA376_RS08005	COG0284	orotidine-5'-phosphate decarboxylase activity
DA376_RS08010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA376_RS08020	COG0306	phosphate transporter
DA376_RS08035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA376_RS08040	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DA376_RS08045	COG1648	precorrin-2 dehydrogenase activity
DA376_RS08060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA376_RS08065	COG1561	YicC-like family, N-terminal region
DA376_RS08075	COG0194	GDP metabolic process
DA376_RS08085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA376_RS08090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA376_RS08095	COG0242	peptide deformylase activity
DA376_RS08105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA376_RS08105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA376_RS08115	COG0631	protein serine/threonine phosphatase activity
DA376_RS08120	COG0515	serine threonine protein kinase
DA376_RS08120	COG2815	serine threonine protein kinase
DA376_RS08130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA376_RS08135	COG1564	THIamine pyrophosphokinase
DA376_RS08150	COG1302	Protein conserved in bacteria
DA376_RS08155	COG1461	Dihydroxyacetone kinase
DA376_RS08160	COG1760	l-serine dehydratase
DA376_RS08165	COG1760	l-serine dehydratase
DA376_RS08170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DA376_RS08185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA376_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS08205	COG1196	nuclear chromosome segregation
DA376_RS08210	COG0552	protein localization to endoplasmic reticulum
DA376_RS08225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA376_RS08235	COG1837	Belongs to the UPF0109 family
DA376_RS08260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA376_RS08275	COG2257	FlhB HrpN YscU SpaS Family
DA376_RS08285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DA376_RS08290	COG0758	DNA mediated transformation
DA376_RS08305	COG4974	Belongs to the 'phage' integrase family
DA376_RS08325	COG1815	bacterial-type flagellum-dependent cell motility
DA376_RS08330	COG1558	bacterial-type flagellum-dependent cell motility
DA376_RS08335	COG1677	Flagellar hook-basal body complex protein FliE
DA376_RS08340	COG1766	The M ring may be actively involved in energy transduction
DA376_RS08345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA376_RS08350	COG1317	bacterial-type flagellum organization
DA376_RS08355	COG1157	protein secretion by the type III secretion system
DA376_RS08360	COG2882	bacterial-type flagellum organization
DA376_RS08365	COG3334	PFAM MgtE intracellular
DA376_RS08370	COG3144	bacterial-type flagellum assembly
DA376_RS08375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA376_RS08380	COG4786	Flagellar basal body rod
DA376_RS08385	COG1582	Flagellar protein (FlbD)
DA376_RS08390	COG1580	Controls the rotational direction of flagella during chemotaxis
DA376_RS08395	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA376_RS08400	COG1776	CheC inhibitor of MCP methylation
DA376_RS08400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA376_RS08405	COG2201	protein-glutamate methylesterase activity
DA376_RS08410	COG3190	flagellar
DA376_RS08415	COG1338	Plays a role in the flagellum-specific transport system
DA376_RS08420	COG1987	bacterial-type flagellum assembly
DA376_RS08425	COG1684	flagellar biosynthetic protein fliR
DA376_RS08430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA376_RS08435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA376_RS08440	COG1419	protein localization to endoplasmic reticulum
DA376_RS08445	COG0455	bacterial-type flagellum organization
DA376_RS08450	COG2201	protein-glutamate methylesterase activity
DA376_RS08455	COG0643	Histidine kinase
DA376_RS08455	COG2198	Histidine kinase
DA376_RS08460	COG0835	chemotaxis
DA376_RS08465	COG1776	CheC inhibitor of MCP methylation
DA376_RS08475	COG1191	sigma factor activity
DA376_RS08505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA376_RS08510	COG4589	Belongs to the CDS family
DA376_RS08520	COG0750	zinc metalloprotease
DA376_RS08530	COG2176	DNA-directed DNA polymerase activity
DA376_RS08540	COG0195	Participates in both transcription termination and antitermination
DA376_RS08545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DA376_RS08550	COG1358	cellular component organization or biogenesis
DA376_RS08560	COG1550	Protein conserved in bacteria
DA376_RS08575	COG0196	riboflavin kinase activity
DA376_RS08590	COG0726	polysaccharide deacetylase
DA376_RS08595	COG0612	Peptidase, M16
DA376_RS08600	COG1873	PFAM PRC-barrel domain
DA376_RS08605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA376_RS08610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA376_RS08615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA376_RS08620	COG0527	aspartate kinase activity
DA376_RS08630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DA376_RS08635	COG0740	serine-type endopeptidase activity
DA376_RS08645	COG1674	ftsk spoiiie
DA376_RS08645	COG4980	gas vesicle protein
DA376_RS08650	COG2188	Transcriptional regulator
DA376_RS08655	COG2814	Major facilitator Superfamily
DA376_RS08660	COG1846	Transcriptional regulator
DA376_RS08665	COG2409	Drug exporters of the RND superfamily
DA376_RS08665	COG1033	growth of symbiont in host cell
DA376_RS08670	COG0612	Peptidase, M16
DA376_RS08675	COG0612	Peptidase, M16
DA376_RS08680	COG0300	oxidoreductase activity
DA376_RS08695	COG1426	Protein conserved in bacteria
DA376_RS08700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA376_RS08715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA376_RS08725	COG1692	metallophosphoesterase
DA376_RS08730	COG2359	stage V sporulation protein S
DA376_RS08750	COG4550	Control of competence regulator ComK, YlbF/YmcA
DA376_RS08795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS08800	COG3425	synthase
DA376_RS08805	COG1024	Enoyl-CoA hydratase
DA376_RS08810	COG1024	Enoyl-CoA hydratase
DA376_RS08815	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS08815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS08815	COG3321	synthase
DA376_RS08815	COG0300	oxidoreductase activity
DA376_RS08820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS08820	COG0300	oxidoreductase activity
DA376_RS08820	COG3321	synthase
DA376_RS08820	COG4221	oxidoreductase activity
DA376_RS08825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS08825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS08825	COG3321	synthase
DA376_RS08825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS08825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS08825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS08825	COG3321	synthase
DA376_RS08825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS08830	COG4221	oxidoreductase activity
DA376_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS08830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS08830	COG3321	synthase
DA376_RS08835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA376_RS08835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS08835	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DA376_RS08835	COG3321	synthase
DA376_RS08840	COG2124	cytochrome p450
DA376_RS08845	COG3209	COG3209 Rhs family protein
DA376_RS08850	COG3619	membrane
DA376_RS08860	COG1404	Belongs to the peptidase S8 family
DA376_RS08870	COG4195	phage-related replication protein
DA376_RS08875	COG1764	response to oxidative stress
DA376_RS08885	COG2076	Multidrug Resistance protein
DA376_RS08925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA376_RS08930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA376_RS08935	COG4112	unkown
DA376_RS08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS08950	COG0464	growth
DA376_RS08955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA376_RS08960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DA376_RS08965	COG0789	Transcriptional regulator
DA376_RS08970	COG0174	glutamine synthetase
DA376_RS09015	COG2211	Major facilitator Superfamily
DA376_RS09020	COG3507	Belongs to the glycosyl hydrolase 43 family
DA376_RS09035	COG1070	Carbohydrate kinase
DA376_RS09040	COG3848	Pyruvate phosphate dikinase
DA376_RS09040	COG0574	Belongs to the PEP-utilizing enzyme family
DA376_RS09070	COG1064	alcohol dehydrogenase
DA376_RS09075	COG4451	ribulose bisphosphate carboxylase, small
DA376_RS09075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA376_RS09120	COG3397	chitin binding
DA376_RS09135	COG5434	Belongs to the glycosyl hydrolase 28 family
DA376_RS09140	COG0756	dUTP diphosphatase activity
DA376_RS09150	COG4195	phage-related replication protein
DA376_RS09180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA376_RS09190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DA376_RS09210	COG0785	Cytochrome C biogenesis protein
DA376_RS09215	COG2201	protein-glutamate methylesterase activity
DA376_RS09220	COG4846	Membrane protein involved in cytochrome C biogenesis
DA376_RS09230	COG0071	Belongs to the small heat shock protein (HSP20) family
DA376_RS09245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DA376_RS09250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS09270	COG0824	Thioesterase
DA376_RS09280	COG4841	protein insertion into membrane
DA376_RS09290	COG1832	CoA-binding protein
DA376_RS09295	COG0187	DNA topoisomerase II activity
DA376_RS09300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA376_RS09310	COG1115	amino acid carrier protein
DA376_RS09320	COG1063	alcohol dehydrogenase
DA376_RS09325	COG0800	Aldolase
DA376_RS09330	COG1312	Catalyzes the dehydration of D-mannonate
DA376_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS09340	COG1609	Transcriptional regulator
DA376_RS09345	COG2271	Major facilitator Superfamily
DA376_RS09400	COG2205	protein histidine kinase activity
DA376_RS09405	COG0745	RESPONSE REGULATOR receiver
DA376_RS09415	COG3507	Belongs to the glycosyl hydrolase 43 family
DA376_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS09445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DA376_RS09450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DA376_RS09455	COG2610	gluconate transmembrane transporter activity
DA376_RS09460	COG2124	cytochrome p450
DA376_RS09480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA376_RS09490	COG2246	polysaccharide biosynthetic process
DA376_RS09500	COG0586	Pfam SNARE associated Golgi protein
DA376_RS09505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA376_RS09510	COG1024	Enoyl-CoA hydratase
DA376_RS09515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA376_RS09520	COG0511	ligase activity, forming carbon-carbon bonds
DA376_RS09525	COG0439	Biotin carboxylase
DA376_RS09530	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS09535	COG1960	acyl-CoA dehydrogenase activity
DA376_RS09540	COG1649	PFAM Uncharacterised BCR, COG1649
DA376_RS09550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS09550	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DA376_RS09555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS09560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS09565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS09570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS09580	COG2027	D-alanyl-D-alanine carboxypeptidase
DA376_RS09585	COG2017	converts alpha-aldose to the beta-anomer
DA376_RS09590	COG0534	Mate efflux family protein
DA376_RS09605	COG0582	viral genome integration into host DNA
DA376_RS09610	COG0166	Belongs to the GPI family
DA376_RS09615	COG0405	Gamma-glutamyltransferase
DA376_RS09620	COG2814	Major facilitator Superfamily
DA376_RS09625	COG0640	Transcriptional regulator
DA376_RS09630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DA376_RS09645	COG0604	alcohol dehydrogenase
DA376_RS09650	COG0493	'glutamate synthase
DA376_RS09655	COG0067	glutamate synthase
DA376_RS09655	COG0069	glutamate synthase activity
DA376_RS09655	COG0070	glutamate synthase
DA376_RS09660	COG0583	DNA-binding transcription factor activity
DA376_RS09665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA376_RS09680	COG0300	oxidoreductase activity
DA376_RS09685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DA376_RS09695	COG2814	Major facilitator Superfamily
DA376_RS09700	COG1070	Carbohydrate kinase
DA376_RS09705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA376_RS09710	COG0243	molybdopterin cofactor binding
DA376_RS09740	COG5444	nuclease activity
DA376_RS09745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA376_RS09750	COG0662	Cupin 2, conserved barrel domain protein
DA376_RS09750	COG2207	Transcriptional regulator
DA376_RS09755	COG1309	transcriptional regulator
DA376_RS09760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS09770	COG0640	Transcriptional regulator
DA376_RS09775	COG0741	lytic transglycosylase activity
DA376_RS09780	COG2322	membrane
DA376_RS09795	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA376_RS09805	COG1388	LysM domain
DA376_RS09805	COG3584	3D domain protein
DA376_RS09810	COG0514	ATP-dependent DNA helicase (RecQ)
DA376_RS09820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA376_RS09825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA376_RS09840	COG0071	Belongs to the small heat shock protein (HSP20) family
DA376_RS09870	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS09875	COG1657	PFAM Prenyltransferase squalene oxidase
DA376_RS09880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA376_RS09885	COG0733	neurotransmitter:sodium symporter activity
DA376_RS09890	COG0385	Bile acid
DA376_RS09895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS09900	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA376_RS09910	COG4548	von Willebrand factor, type A
DA376_RS09915	COG0714	Associated with various cellular activities
DA376_RS09920	COG2032	superoxide dismutase activity
DA376_RS09925	COG1388	LysM domain
DA376_RS09925	COG0791	NLP P60 protein
DA376_RS09930	COG1819	glycosyl
DA376_RS09935	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DA376_RS09940	COG0534	Mate efflux family protein
DA376_RS09945	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS09950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA376_RS09955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA376_RS09965	COG2962	Rard protein
DA376_RS09980	COG1942	4-Oxalocrotonate Tautomerase
DA376_RS09990	COG1733	regulation of RNA biosynthetic process
DA376_RS09995	COG0778	Nitroreductase
DA376_RS10000	COG0400	carboxylic ester hydrolase activity
DA376_RS10005	COG0346	lactoylglutathione lyase activity
DA376_RS10015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA376_RS10025	COG2723	6-phospho-beta-galactosidase activity
DA376_RS10030	COG2188	Transcriptional regulator
DA376_RS10035	COG0793	Belongs to the peptidase S41A family
DA376_RS10035	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS10040	COG2226	methyltransferase
DA376_RS10050	COG1876	peptidase activity
DA376_RS10070	COG0671	phosphoesterase, PA-phosphatase related
DA376_RS10095	COG1509	lysine 2,3-aminomutase activity
DA376_RS10100	COG0456	acetyltransferase
DA376_RS10105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA376_RS10110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DA376_RS10115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DA376_RS10120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA376_RS10125	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DA376_RS10135	COG0456	acetyltransferase
DA376_RS10140	COG0463	Glycosyl transferase, family 2
DA376_RS10155	COG4641	Protein conserved in bacteria
DA376_RS10165	COG1086	Polysaccharide biosynthesis protein
DA376_RS10205	COG0457	Tetratricopeptide repeat
DA376_RS10215	COG3391	amine dehydrogenase activity
DA376_RS10240	COG5444	nuclease activity
DA376_RS10245	COG4282	regulation of fungal-type cell wall biogenesis
DA376_RS10250	COG1525	nuclease
DA376_RS10255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA376_RS10275	COG1846	Transcriptional regulator
DA376_RS10280	COG4698	Protein conserved in bacteria
DA376_RS10285	COG2755	lipolytic protein G-D-S-L family
DA376_RS10290	COG1999	signal sequence binding
DA376_RS10300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA376_RS10305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DA376_RS10310	COG1272	protein, Hemolysin III
DA376_RS10315	COG0204	Acyl-transferase
DA376_RS10320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA376_RS10335	COG2136	Putative SAM-dependent methyltransferase
DA376_RS10335	COG2521	methyltransferase
DA376_RS10350	COG1413	lyase activity
DA376_RS10355	COG1418	mRNA catabolic process
DA376_RS10360	COG0386	Belongs to the glutathione peroxidase family
DA376_RS10370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA376_RS10375	COG1278	Cold shock
DA376_RS10395	COG0328	RNA-DNA hybrid ribonuclease activity
DA376_RS10400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA376_RS10405	COG0328	RNA-DNA hybrid ribonuclease activity
DA376_RS10415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA376_RS10430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DA376_RS10440	COG1755	Isoprenylcysteine carboxyl methyltransferase
DA376_RS10445	COG3424	synthase
DA376_RS10465	COG1335	isochorismatase
DA376_RS10475	COG2233	PERMEase
DA376_RS10485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DA376_RS10490	COG1199	ATP-dependent helicase activity
DA376_RS10505	COG0116	Belongs to the methyltransferase superfamily
DA376_RS10530	COG3359	exonuclease
DA376_RS10535	COG1205	dead DEAH box helicase
DA376_RS10535	COG1111	helicase
DA376_RS10540	COG2190	(PTS) system
DA376_RS10545	COG0071	Belongs to the small heat shock protein (HSP20) family
DA376_RS10585	COG4499	WXG100 protein secretion system (Wss), protein YukC
DA376_RS10585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA376_RS10595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DA376_RS10600	COG3935	DnaD domain protein
DA376_RS10610	COG0436	Aminotransferase
DA376_RS10615	COG5353	protein conserved in bacteria
DA376_RS10625	COG1199	ATP-dependent helicase activity
DA376_RS10625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA376_RS10655	COG0438	transferase activity, transferring glycosyl groups
DA376_RS10660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA376_RS10675	COG1694	Mazg nucleotide pyrophosphohydrolase
DA376_RS10680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS10695	COG4347	Protein of unknown function (DUF1405)
DA376_RS10700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA376_RS10700	COG2010	Cytochrome c
DA376_RS10705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA376_RS10710	COG0723	plastoquinol--plastocyanin reductase activity
DA376_RS10725	COG0457	Tetratricopeptide repeat
DA376_RS10735	COG0287	Prephenate dehydrogenase
DA376_RS10770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA376_RS10775	COG4401	Chorismate mutase type I
DA376_RS10790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DA376_RS10795	COG0105	UTP biosynthetic process
DA376_RS10800	COG0142	geranyltranstransferase activity
DA376_RS10810	COG0142	geranyltranstransferase activity
DA376_RS10825	COG0776	regulation of translation
DA376_RS10830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DA376_RS10870	COG0539	negative regulation of cytoplasmic translation
DA376_RS10880	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DA376_RS10885	COG2959	enzyme of heme biosynthesis
DA376_RS10890	COG3773	Cell wall hydrolase
DA376_RS10890	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS10895	COG2339	peptidase activity
DA376_RS10900	COG0492	ferredoxin-NADP+ reductase activity
DA376_RS10905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA376_RS10910	COG4862	establishment of competence for transformation
DA376_RS10915	COG1408	metallophosphoesterase
DA376_RS10925	COG1388	LysM domain
DA376_RS10930	COG1266	CAAX protease self-immunity
DA376_RS10935	COG0514	ATP-dependent DNA helicase (RecQ)
DA376_RS10940	COG4955	Helix-turn-helix domain
DA376_RS10945	COG1141	Ferredoxin
DA376_RS10950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DA376_RS10955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA376_RS10965	COG1595	DNA-templated transcription, initiation
DA376_RS10970	COG5002	protein histidine kinase activity
DA376_RS10975	COG0745	RESPONSE REGULATOR receiver
DA376_RS10980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA376_RS10985	COG1333	cytochrome c biogenesis protein
DA376_RS10990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS10995	COG1187	pseudouridine synthase activity
DA376_RS11000	COG0700	Nucleoside recognition
DA376_RS11005	COG2715	membrane protein required for spore maturation
DA376_RS11010	COG1686	Belongs to the peptidase S11 family
DA376_RS11035	COG1547	Domain of unknown function (DUF309)
DA376_RS11045	COG0456	acetyltransferase
DA376_RS11060	COG0307	riboflavin synthase, alpha
DA376_RS11065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA376_RS11065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA376_RS11075	COG0681	Belongs to the peptidase S26 family
DA376_RS11085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA376_RS11090	COG4086	secreted protein
DA376_RS11095	COG0019	diaminopimelate decarboxylase activity
DA376_RS11100	COG0697	spore germination
DA376_RS11115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA376_RS11135	COG1191	sigma factor activity
DA376_RS11145	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS11150	COG1686	Belongs to the peptidase S11 family
DA376_RS11155	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA376_RS11160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA376_RS11165	COG4974	Belongs to the 'phage' integrase family
DA376_RS11175	COG0735	belongs to the Fur family
DA376_RS11180	COG1300	Membrane
DA376_RS11195	COG0281	malic enzyme
DA376_RS11200	COG1757	Na H antiporter
DA376_RS11205	COG1027	Aspartate ammonia-lyase
DA376_RS11210	COG0252	asparaginase activity
DA376_RS11215	COG1396	sequence-specific DNA binding
DA376_RS11220	COG1379	DNA repair
DA376_RS11225	COG0494	nUDIX hydrolase
DA376_RS11235	COG0667	Aldo Keto reductase
DA376_RS11245	COG1073	alpha beta
DA376_RS11255	COG4918	Iron-sulphur cluster biosynthesis
DA376_RS11260	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DA376_RS11260	COG0456	acetyltransferase
DA376_RS11265	COG2329	Antibiotic biosynthesis monooxygenase
DA376_RS11270	COG0456	acetyltransferase
DA376_RS11275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DA376_RS11290	COG0628	permease
DA376_RS11300	COG0346	lactoylglutathione lyase activity
DA376_RS11310	COG3048	D-serine ammonia-lyase activity
DA376_RS11315	COG0300	oxidoreductase activity
DA376_RS11320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS11325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA376_RS11330	COG1024	Enoyl-CoA hydratase
DA376_RS11335	COG3425	synthase
DA376_RS11340	COG2124	cytochrome p450
DA376_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS11345	COG3321	synthase
DA376_RS11345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS11350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11350	COG3321	synthase
DA376_RS11350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS11355	COG0300	oxidoreductase activity
DA376_RS11355	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS11355	COG3321	synthase
DA376_RS11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11360	COG3321	synthase
DA376_RS11360	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS11360	COG0300	oxidoreductase activity
DA376_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11365	COG3321	synthase
DA376_RS11365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS11370	COG3321	synthase
DA376_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11370	COG0300	oxidoreductase activity
DA376_RS11370	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS11375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA376_RS11375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS11375	COG3321	synthase
DA376_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS11385	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS11400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA376_RS11400	COG2070	2-Nitropropane dioxygenase
DA376_RS11410	COG0250	Participates in transcription elongation, termination and antitermination
DA376_RS11435	COG0596	Alpha beta hydrolase
DA376_RS11450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DA376_RS11455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DA376_RS11470	COG0706	membrane insertase activity
DA376_RS11475	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA376_RS11480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA376_RS11485	COG0346	lactoylglutathione lyase activity
DA376_RS11495	COG4129	membrane
DA376_RS11500	COG1126	abc transporter atp-binding protein
DA376_RS11505	COG0765	amino acid transport
DA376_RS11510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA376_RS11520	COG1597	lipid kinase activity
DA376_RS11525	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA376_RS11530	COG0022	dehydrogenase e1 component
DA376_RS11535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA376_RS11540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA376_RS11545	COG3426	butyrate kinase activity
DA376_RS11550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA376_RS11555	COG0280	phosphate acetyltransferase
DA376_RS11560	COG3290	protein histidine kinase activity
DA376_RS11560	COG3829	transcription factor binding
DA376_RS11570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DA376_RS11575	COG2079	MmgE PrpD family protein
DA376_RS11580	COG0372	Belongs to the citrate synthase family
DA376_RS11585	COG1960	acyl-CoA dehydrogenase activity
DA376_RS11590	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA376_RS11595	COG0183	Belongs to the thiolase family
DA376_RS11600	COG0584	glycerophosphoryl diester phosphodiesterase
DA376_RS11605	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS11630	COG1902	pentaerythritol trinitrate reductase activity
DA376_RS11645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA376_RS11650	COG0745	RESPONSE REGULATOR receiver
DA376_RS11655	COG0750	zinc metalloprotease
DA376_RS11660	COG0497	DNA recombination
DA376_RS11670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DA376_RS11680	COG0142	geranyltranstransferase activity
DA376_RS11690	COG1570	exodeoxyribonuclease VII activity
DA376_RS11705	COG1302	Protein conserved in bacteria
DA376_RS11710	COG0439	Biotin carboxylase
DA376_RS11715	COG0511	ligase activity, forming carbon-carbon bonds
DA376_RS11755	COG3854	ATPases associated with a variety of cellular activities
DA376_RS11770	COG0006	proline dipeptidase activity
DA376_RS11780	COG3872	metal-dependent enzyme
DA376_RS11790	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA376_RS11805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA376_RS11825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA376_RS11840	COG1396	sequence-specific DNA binding
DA376_RS11850	COG0681	Belongs to the peptidase S26 family
DA376_RS11875	COG4940	Competence protein ComGF
DA376_RS11885	COG4970	Tfp pilus assembly protein FimT
DA376_RS11890	COG4537	Required for transformation and DNA binding
DA376_RS11895	COG1459	type II secretion system
DA376_RS11900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA376_RS11905	COG0598	Magnesium transport protein CorA
DA376_RS11910	COG1253	flavin adenine dinucleotide binding
DA376_RS11915	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS11925	COG1393	Belongs to the ArsC family
DA376_RS11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS11945	COG0011	TIGRFAM Protein of
DA376_RS11955	COG2866	Carboxypeptidase
DA376_RS11960	COG1940	carbohydrate kinase activity
DA376_RS11965	COG4483	Protein conserved in bacteria
DA376_RS11970	COG1757	Na H antiporter
DA376_RS11980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DA376_RS11995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA376_RS12000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA376_RS12005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA376_RS12010	COG0581	inorganic phosphate transmembrane transporter activity
DA376_RS12015	COG0573	inorganic phosphate transmembrane transporter activity
DA376_RS12020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA376_RS12025	COG0768	penicillin binding
DA376_RS12030	COG0477	Major facilitator Superfamily
DA376_RS12035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA376_RS12040	COG2839	Protein conserved in bacteria
DA376_RS12045	COG5521	maltodextrose utilization protein MalA
DA376_RS12050	COG1388	LysM domain
DA376_RS12060	COG4709	membrane
DA376_RS12065	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DA376_RS12070	COG0735	belongs to the Fur family
DA376_RS12075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS12090	COG0513	Belongs to the DEAD box helicase family
DA376_RS12105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DA376_RS12110	COG2384	SAM-dependent methyltransferase
DA376_RS12115	COG2010	Cytochrome c
DA376_RS12120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA376_RS12125	COG0358	DNA primase activity
DA376_RS12140	COG0517	IMP dehydrogenase activity
DA376_RS12145	COG0751	glycine-tRNA ligase activity
DA376_RS12165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DA376_RS12170	COG0295	cytidine deaminase activity
DA376_RS12175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA376_RS12185	COG1480	7TM receptor with intracellular HD hydrolase
DA376_RS12190	COG1702	phosphate starvation-inducible protein PhoH
DA376_RS12195	COG0561	phosphatase activity
DA376_RS12210	COG4864	UPF0365 protein
DA376_RS12215	COG1030	water channel activity
DA376_RS12220	COG1610	YqeY-like protein
DA376_RS12230	COG1283	sodium-dependent phosphate transmembrane transporter activity
DA376_RS12235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA376_RS12240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DA376_RS12270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA376_RS12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS12300	COG1466	dna polymerase III delta subunit
DA376_RS12310	COG0658	competence protein
DA376_RS12310	COG2333	competence protein COMEC
DA376_RS12315	COG2131	deaminase
DA376_RS12320	COG1596	polysaccharide export
DA376_RS12320	COG1555	photosystem II stabilization
DA376_RS12325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA376_RS12330	COG2226	methyltransferase
DA376_RS12335	COG0799	negative regulation of ribosome biogenesis
DA376_RS12340	COG1713	HD superfamily hydrolase involved in NAD metabolism
DA376_RS12350	COG1534	Rna-binding protein
DA376_RS12355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA376_RS12360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA376_RS12365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DA376_RS12375	COG2755	lipolytic protein G-D-S-L family
DA376_RS12385	COG0398	Pfam SNARE associated Golgi protein
DA376_RS12410	COG1794	racemase activity, acting on amino acids and derivatives
DA376_RS12420	COG1733	regulation of RNA biosynthetic process
DA376_RS12425	COG0656	L-ascorbic acid biosynthetic process
DA376_RS12455	COG3677	Transposase
DA376_RS12495	COG0642	Histidine kinase
DA376_RS12495	COG5002	protein histidine kinase activity
DA376_RS12500	COG0745	RESPONSE REGULATOR receiver
DA376_RS12505	COG2311	Membrane
DA376_RS12510	COG0454	-acetyltransferase
DA376_RS12515	COG0563	adenylate kinase activity
DA376_RS12525	COG2814	Major facilitator Superfamily
DA376_RS12535	COG0456	acetyltransferase
DA376_RS12540	COG2318	DinB family
DA376_RS12550	COG0561	phosphatase activity
DA376_RS12555	COG0561	phosphatase activity
DA376_RS12565	COG1482	cell wall glycoprotein biosynthetic process
DA376_RS12570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA376_RS12570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS12570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA376_RS12575	COG3711	transcriptional antiterminator
DA376_RS12575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS12585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DA376_RS12590	COG0583	DNA-binding transcription factor activity
DA376_RS12595	COG2814	Major facilitator Superfamily
DA376_RS12600	COG2124	cytochrome p450
DA376_RS12600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA376_RS12605	COG1309	transcriptional regulator
DA376_RS12610	COG2226	methyltransferase
DA376_RS12625	COG2116	formate transmembrane transporter activity
DA376_RS12630	COG5609	conserved protein (DUF2294)
DA376_RS12635	COG3383	formate dehydrogenase (NAD+) activity
DA376_RS12640	COG2427	Protein of unknown function (DUF1641)
DA376_RS12650	COG0626	cystathionine gamma-synthase activity
DA376_RS12655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA376_RS12680	COG0768	penicillin binding
DA376_RS12695	COG0826	peptidase U32
DA376_RS12700	COG0826	peptidase U32
DA376_RS12705	COG4122	O-methyltransferase activity
DA376_RS12710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA376_RS12735	COG0628	permease
DA376_RS12740	COG1126	abc transporter atp-binding protein
DA376_RS12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA376_RS12750	COG0765	amino acid transport
DA376_RS12755	COG0765	amino acid transport
DA376_RS12770	COG3881	PFAM PRC-barrel domain
DA376_RS12775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA376_RS12780	COG0457	Tetratricopeptide repeat
DA376_RS12790	COG1104	cysteine desulfurase activity
DA376_RS12795	COG1959	2 iron, 2 sulfur cluster binding
DA376_RS12800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA376_RS12805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA376_RS12825	COG3103	Sh3 type 3 domain protein
DA376_RS12825	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS12825	COG4991	sh3 domain protein
DA376_RS12835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA376_RS12845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DA376_RS12845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DA376_RS12850	COG5416	Lipopolysaccharide assembly protein A domain
DA376_RS12855	COG0490	domain, Protein
DA376_RS12860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA376_RS12860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA376_RS12870	COG2244	polysaccharide biosynthetic process
DA376_RS12875	COG2323	membrane
DA376_RS12885	COG1862	Preprotein translocase
DA376_RS12925	COG1388	LysM domain
DA376_RS12935	COG0157	Belongs to the NadC ModD family
DA376_RS12940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA376_RS12945	COG1104	cysteine desulfurase activity
DA376_RS12950	COG1827	regulation of RNA biosynthetic process
DA376_RS12955	COG0077	Prephenate dehydratase
DA376_RS12970	COG3290	protein histidine kinase activity
DA376_RS12975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DA376_RS12980	COG2868	ribosomal protein
DA376_RS12990	COG1994	Peptidase M50
DA376_RS12995	COG0739	heme binding
DA376_RS13000	COG2894	cell division
DA376_RS13005	COG0850	regulation of cytokinetic process
DA376_RS13010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DA376_RS13020	COG1077	Cell shape determining protein MreB Mrl
DA376_RS13040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DA376_RS13045	COG0285	dihydrofolate synthase activity
DA376_RS13050	COG0525	valine-tRNA ligase activity
DA376_RS13060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA376_RS13065	COG1388	LysM domain
DA376_RS13075	COG0113	porphobilinogen synthase activity
DA376_RS13080	COG1587	Uroporphyrinogen-III synthase
DA376_RS13090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA376_RS13110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA376_RS13115	COG1067	ATP-dependent peptidase activity
DA376_RS13115	COG0470	DNA polymerase III
DA376_RS13130	COG0457	Tetratricopeptide repeat
DA376_RS13130	COG1477	protein flavinylation
DA376_RS13145	COG0473	3-isopropylmalate dehydrogenase activity
DA376_RS13160	COG0440	acetolactate synthase activity
DA376_RS13165	COG0028	Belongs to the TPP enzyme family
DA376_RS13190	COG0622	Phosphoesterase
DA376_RS13195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA376_RS13205	COG5401	PFAM Sporulation and spore germination
DA376_RS13215	COG1846	Transcriptional regulator
DA376_RS13220	COG2197	response regulator
DA376_RS13225	COG0824	Thioesterase
DA376_RS13230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA376_RS13235	COG1053	succinate dehydrogenase
DA376_RS13240	COG2009	succinate dehydrogenase
DA376_RS13245	COG1719	4-vinyl reductase, 4VR
DA376_RS13250	COG0527	aspartate kinase activity
DA376_RS13265	COG3118	belongs to the thioredoxin family
DA376_RS13270	COG3534	alpha-L-arabinofuranosidase
DA376_RS13275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DA376_RS13280	COG2086	electron transfer activity
DA376_RS13285	COG1024	Enoyl-CoA hydratase
DA376_RS13290	COG1309	transcriptional regulator
DA376_RS13295	COG0318	PFAM AMP-dependent synthetase and ligase
DA376_RS13305	COG3766	membrane
DA376_RS13315	COG1796	DNA polymerase
DA376_RS13315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA376_RS13320	COG1286	toxin biosynthetic process
DA376_RS13335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA376_RS13335	COG0072	phenylalanine-tRNA ligase activity
DA376_RS13340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DA376_RS13345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA376_RS13355	COG3835	regulator
DA376_RS13360	COG0277	FAD linked oxidase domain protein
DA376_RS13365	COG0247	lactate metabolic process
DA376_RS13370	COG1966	Carbon starvation protein
DA376_RS13375	COG3534	alpha-L-arabinofuranosidase
DA376_RS13380	COG0395	ABC-type sugar transport system, permease component
DA376_RS13385	COG1175	transmembrane transport
DA376_RS13390	COG1653	transport
DA376_RS13400	COG0647	UMP catabolic process
DA376_RS13405	COG0235	Class ii aldolase
DA376_RS13410	COG1069	ribulokinase activity
DA376_RS13415	COG2160	L-arabinose isomerase activity
DA376_RS13420	COG3507	Belongs to the glycosyl hydrolase 43 family
DA376_RS13425	COG1363	Peptidase, m42
DA376_RS13435	COG3326	Membrane
DA376_RS13450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DA376_RS13455	COG1346	cytolysis
DA376_RS13460	COG1380	Effector of murein hydrolase LrgA
DA376_RS13465	COG3279	Response regulator of the LytR AlgR family
DA376_RS13470	COG3275	phosphorelay sensor kinase activity
DA376_RS13480	COG1011	Hydrolase
DA376_RS13495	COG0398	Pfam SNARE associated Golgi protein
DA376_RS13500	COG1484	DNA-dependent DNA replication
DA376_RS13505	COG3611	Membrane attachment protein
DA376_RS13520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA376_RS13525	COG1733	regulation of RNA biosynthetic process
DA376_RS13530	COG2814	Major facilitator Superfamily
DA376_RS13535	COG0656	L-ascorbic acid biosynthetic process
DA376_RS13540	COG0237	dephospho-CoA kinase activity
DA376_RS13545	COG1971	Probably functions as a manganese efflux pump
DA376_RS13550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA376_RS13555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA376_RS13555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA376_RS13560	COG5002	protein histidine kinase activity
DA376_RS13565	COG0745	RESPONSE REGULATOR receiver
DA376_RS13575	COG0538	isocitrate dehydrogenase activity
DA376_RS13580	COG0372	Belongs to the citrate synthase family
DA376_RS13605	COG0628	permease
DA376_RS13610	COG3030	protein affecting phage T7 exclusion by the F plasmid
DA376_RS13615	COG0469	pyruvate kinase activity
DA376_RS13635	COG0281	malic enzyme
DA376_RS13640	COG0587	DNA-directed DNA polymerase activity
DA376_RS13660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DA376_RS13670	COG4109	DRTGG domain
DA376_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS13695	COG0521	Mo-molybdopterin cofactor biosynthetic process
DA376_RS13705	COG0827	DNA restriction-modification system
DA376_RS13710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DA376_RS13715	COG3874	Sporulation protein YtfJ
DA376_RS13725	COG1714	RDD family
DA376_RS13730	COG0616	signal peptide processing
DA376_RS13735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA376_RS13740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DA376_RS13745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA376_RS13760	COG1104	cysteine desulfurase activity
DA376_RS13765	COG1114	Component of the transport system for branched-chain amino acids
DA376_RS13775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA376_RS13780	COG1309	transcriptional regulator
DA376_RS13785	COG1956	GAF domain-containing protein
DA376_RS13790	COG2203	Gaf domain
DA376_RS13790	COG2199	diguanylate cyclase activity
DA376_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS13810	COG4282	regulation of fungal-type cell wall biogenesis
DA376_RS13860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA376_RS13860	COG1017	nitric oxide dioxygenase activity
DA376_RS13875	COG0693	protein deglycase activity
DA376_RS13890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA376_RS13895	COG1378	Sugar-specific transcriptional regulator TrmB
DA376_RS13920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA376_RS13925	COG0454	-acetyltransferase
DA376_RS13930	COG0517	IMP dehydrogenase activity
DA376_RS13935	COG0123	including yeast histone deacetylase and acetoin utilization protein
DA376_RS13940	COG1360	Flagellar Motor Protein
DA376_RS13945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA376_RS13950	COG1609	Transcriptional regulator
DA376_RS13955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DA376_RS13955	COG1605	Chorismate mutase
DA376_RS13960	COG3118	belongs to the thioredoxin family
DA376_RS13965	COG4980	gas vesicle protein
DA376_RS13970	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DA376_RS13980	COG1674	ftsk spoiiie
DA376_RS13985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA376_RS13995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS14005	COG1363	Peptidase, m42
DA376_RS14010	COG5584	Small secreted protein
DA376_RS14015	COG0281	malic enzyme
DA376_RS14020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA376_RS14035	COG0510	thiamine kinase activity
DA376_RS14040	COG1597	lipid kinase activity
DA376_RS14050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DA376_RS14055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA376_RS14060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA376_RS14065	COG2252	PERMEase
DA376_RS14070	COG4473	ABC transporter
DA376_RS14075	COG1131	(ABC) transporter
DA376_RS14085	COG1349	DNA-binding transcription factor activity
DA376_RS14090	COG1187	pseudouridine synthase activity
DA376_RS14095	COG2244	polysaccharide biosynthetic process
DA376_RS14100	COG2081	HI0933 family
DA376_RS14105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA376_RS14115	COG1609	Transcriptional regulator
DA376_RS14120	COG1653	transport
DA376_RS14125	COG1175	transmembrane transport
DA376_RS14130	COG0395	ABC-type sugar transport system, permease component
DA376_RS14135	COG1486	melibiose metabolic process
DA376_RS14145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA376_RS14160	COG2202	Pas domain
DA376_RS14160	COG1366	Belongs to the anti-sigma-factor antagonist family
DA376_RS14165	COG2814	Major facilitator Superfamily
DA376_RS14170	COG5522	Integral membrane protein (intg_mem_TP0381)
DA376_RS14175	COG0577	efflux transmembrane transporter activity
DA376_RS14180	COG1136	(ABC) transporter
DA376_RS14185	COG2205	protein histidine kinase activity
DA376_RS14190	COG0745	RESPONSE REGULATOR receiver
DA376_RS14195	COG0577	efflux transmembrane transporter activity
DA376_RS14200	COG1136	(ABC) transporter
DA376_RS14220	COG1131	(ABC) transporter
DA376_RS14225	COG1725	Transcriptional regulator
DA376_RS14235	COG1242	4 iron, 4 sulfur cluster binding
DA376_RS14240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DA376_RS14250	COG0584	glycerophosphoryl diester phosphodiesterase
DA376_RS14260	COG2267	carboxylic ester hydrolase activity
DA376_RS14265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA376_RS14270	COG1113	amino acid transport
DA376_RS14275	COG0367	asparagine synthase
DA376_RS14295	COG1506	peptidase
DA376_RS14300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA376_RS14305	COG1116	anion transmembrane transporter activity
DA376_RS14310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA376_RS14315	COG0494	nUDIX hydrolase
DA376_RS14320	COG4824	toxin secretion phage lysis holin
DA376_RS14325	COG0783	Belongs to the Dps family
DA376_RS14350	COG0288	reversible hydration of carbon dioxide
DA376_RS14360	COG1271	oxidase subunit
DA376_RS14365	COG1294	oxidase, subunit
DA376_RS14380	COG4948	Mandelate Racemase Muconate Lactonizing
DA376_RS14390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DA376_RS14395	COG0596	Alpha beta hydrolase
DA376_RS14405	COG1169	isochorismate synthase
DA376_RS14410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA376_RS14415	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DA376_RS14540	COG3859	Proton-coupled thiamine transporter YuaJ
DA376_RS14545	COG2268	Band 7 protein
DA376_RS14550	COG1585	Membrane protein implicated in regulation of membrane protease activity
DA376_RS14555	COG2318	DinB family
DA376_RS14565	COG1454	alcohol dehydrogenase
DA376_RS14570	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS14575	COG1510	regulation of RNA biosynthetic process
DA376_RS14585	COG0569	domain protein
DA376_RS14590	COG1705	Flagellar rod assembly protein muramidase FlgJ
DA376_RS14595	COG1017	nitric oxide dioxygenase activity
DA376_RS14595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA376_RS14620	COG0628	permease
DA376_RS14625	COG0673	inositol 2-dehydrogenase activity
DA376_RS14630	COG0693	protein deglycase activity
DA376_RS14635	COG0840	transmembrane signaling receptor activity
DA376_RS14640	COG0840	transmembrane signaling receptor activity
DA376_RS14645	COG0840	transmembrane signaling receptor activity
DA376_RS14650	COG0840	transmembrane signaling receptor activity
DA376_RS14665	COG2070	2-Nitropropane dioxygenase
DA376_RS14670	COG0432	Pfam Uncharacterised protein family UPF0047
DA376_RS14675	COG0366	Alpha amylase catalytic
DA376_RS14680	COG1253	flavin adenine dinucleotide binding
DA376_RS14685	COG2738	Putative neutral zinc metallopeptidase
DA376_RS14700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA376_RS14730	COG1335	isochorismatase
DA376_RS14740	COG1979	alcohol dehydrogenase
DA376_RS14745	COG1979	alcohol dehydrogenase
DA376_RS14750	COG2155	Conserved Protein
DA376_RS14755	COG1098	S1 RNA binding domain
DA376_RS14760	COG0436	Aminotransferase
DA376_RS14765	COG1522	sequence-specific DNA binding
DA376_RS14770	COG2267	carboxylic ester hydrolase activity
DA376_RS14780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DA376_RS14785	COG2205	protein histidine kinase activity
DA376_RS14795	COG5018	Exonuclease
DA376_RS14800	COG2814	Major facilitator Superfamily
DA376_RS14805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA376_RS14810	COG3011	Protein conserved in bacteria
DA376_RS14820	COG3290	protein histidine kinase activity
DA376_RS14825	COG4565	transcriptional regulatory protein
DA376_RS14830	COG1744	ABC transporter substrate-binding protein PnrA-like
DA376_RS14835	COG3845	ABC transporter
DA376_RS14840	COG4603	Belongs to the binding-protein-dependent transport system permease family
DA376_RS14845	COG1079	Belongs to the binding-protein-dependent transport system permease family
DA376_RS14855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA376_RS14855	COG2111	Na H antiporter
DA376_RS14860	COG2111	Na H antiporter
DA376_RS14865	COG1006	Multisubunit Na H antiporter MnhC subunit
DA376_RS14870	COG0651	ATP synthesis coupled electron transport
DA376_RS14875	COG1863	multisubunit Na H antiporter MnhE subunit
DA376_RS14880	COG2212	antiporter activity
DA376_RS14885	COG1320	monovalent cation:proton antiporter activity
DA376_RS14890	COG2050	protein possibly involved in aromatic compounds catabolism
DA376_RS14895	COG2197	response regulator
DA376_RS14900	COG4585	Histidine kinase
DA376_RS14930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DA376_RS14935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DA376_RS14940	COG1335	isochorismatase
DA376_RS14945	COG5506	Protein of unknown function (DUF1694)
DA376_RS14960	COG0628	permease
DA376_RS14970	COG1418	mRNA catabolic process
DA376_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS14985	COG1511	domain protein
DA376_RS14990	COG1674	ftsk spoiiie
DA376_RS14990	COG0433	COG0433 Predicted ATPase
DA376_RS14995	COG4499	WXG100 protein secretion system (Wss), protein YukC
DA376_RS15000	COG5417	Belongs to the EsaB family
DA376_RS15005	COG4842	Belongs to the WXG100 family
DA376_RS15010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DA376_RS15010	COG2508	Transcriptional regulator
DA376_RS15015	COG0686	Belongs to the AlaDH PNT family
DA376_RS15020	COG5634	Uncharacterized conserved protein (DUF2278)
DA376_RS15025	COG3251	PFAM MbtH domain protein
DA376_RS15030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA376_RS15035	COG3433	isochorismatase activity
DA376_RS15035	COG1535	isochorismatase
DA376_RS15040	COG1021	2,3-dihydroxybenzoate-AMP ligase
DA376_RS15045	COG1169	isochorismate synthase
DA376_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS15055	COG2819	hydrolase of the alpha beta superfamily
DA376_RS15060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA376_RS15065	COG1268	BioY protein
DA376_RS15070	COG2056	Na+-H+ antiporter family
DA376_RS15080	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DA376_RS15085	COG3584	3D domain protein
DA376_RS15100	COG1252	NADH dehydrogenase
DA376_RS15130	COG1131	(ABC) transporter
DA376_RS15150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA376_RS15155	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DA376_RS15160	COG0316	Belongs to the HesB IscA family
DA376_RS15170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA376_RS15180	COG1252	NADH dehydrogenase
DA376_RS15185	COG4837	Protein of unknown function (DUF1462)
DA376_RS15190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DA376_RS15195	COG4946	Tricorn protease homolog
DA376_RS15195	COG1506	peptidase
DA376_RS15195	COG0823	Involved in the tonB-independent uptake of proteins
DA376_RS15205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DA376_RS15210	COG0460	homoserine dehydrogenase
DA376_RS15215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA376_RS15220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DA376_RS15225	COG0647	UMP catabolic process
DA376_RS15230	COG2445	Protein of unknown function DUF86
DA376_RS15235	COG4470	Protein conserved in bacteria
DA376_RS15250	COG0739	heme binding
DA376_RS15260	COG0737	Belongs to the 5'-nucleotidase family
DA376_RS15265	COG0730	response to heat
DA376_RS15270	COG1801	Protein of unknown function DUF72
DA376_RS15285	COG2508	Transcriptional regulator
DA376_RS15310	COG2814	Major facilitator Superfamily
DA376_RS15315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DA376_RS15320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA376_RS15325	COG2356	endonuclease I
DA376_RS15330	COG3842	ATPase activity
DA376_RS15335	COG2188	Transcriptional regulator
DA376_RS15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA376_RS15345	COG0395	ABC-type sugar transport system, permease component
DA376_RS15350	COG1175	transmembrane transport
DA376_RS15355	COG1653	transport
DA376_RS15360	COG2222	sugar isomerase
DA376_RS15365	COG0789	Transcriptional regulator
DA376_RS15390	COG0322	excinuclease ABC activity
DA376_RS15395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA376_RS15415	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS15420	COG0719	Fe-S assembly protein
DA376_RS15425	COG0822	iron-sulfur transferase activity
DA376_RS15430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA376_RS15435	COG0719	Fe-S assembly protein
DA376_RS15440	COG0396	ATPase activity
DA376_RS15450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA376_RS15455	COG1464	Belongs to the NlpA lipoprotein family
DA376_RS15460	COG2011	ABC-type metal ion transport system permease component
DA376_RS15465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA376_RS15475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA376_RS15480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DA376_RS15495	COG1393	Belongs to the ArsC family
DA376_RS15500	COG1960	acyl-CoA dehydrogenase activity
DA376_RS15505	COG0183	Belongs to the thiolase family
DA376_RS15510	COG1024	Enoyl-CoA hydratase
DA376_RS15510	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA376_RS15530	COG5577	PFAM Coat F domain
DA376_RS15535	COG1846	Transcriptional regulator
DA376_RS15540	COG0477	Major facilitator Superfamily
DA376_RS15545	COG1942	4-Oxalocrotonate Tautomerase
DA376_RS15550	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS15555	COG0583	DNA-binding transcription factor activity
DA376_RS15565	COG0583	DNA-binding transcription factor activity
DA376_RS15590	COG1120	ATPase activity
DA376_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS15610	COG0783	Belongs to the Dps family
DA376_RS15615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA376_RS15620	COG0745	RESPONSE REGULATOR receiver
DA376_RS15625	COG2205	protein histidine kinase activity
DA376_RS15625	COG2770	Histidine kinase
DA376_RS15635	COG1309	transcriptional regulator
DA376_RS15640	COG0114	fumarate hydratase activity
DA376_RS15650	COG0697	spore germination
DA376_RS15655	COG0814	amino acid
DA376_RS15665	COG2197	response regulator
DA376_RS15670	COG4585	Histidine kinase
DA376_RS15675	COG4758	membrane
DA376_RS15680	COG3595	metallopeptidase activity
DA376_RS15685	COG1842	Phage shock protein A
DA376_RS15690	COG4758	membrane
DA376_RS15695	COG2814	Major facilitator Superfamily
DA376_RS15700	COG2096	Adenosyltransferase
DA376_RS15705	COG1120	ATPase activity
DA376_RS15710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS15715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA376_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS15725	COG3386	PFAM SMP-30 Gluconolaconase
DA376_RS15730	COG2205	protein histidine kinase activity
DA376_RS15735	COG0745	RESPONSE REGULATOR receiver
DA376_RS15745	COG1191	sigma factor activity
DA376_RS15755	COG2140	Oxalate decarboxylase
DA376_RS15765	COG1120	ATPase activity
DA376_RS15770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS15775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS15780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA376_RS15785	COG0531	amino acid
DA376_RS15800	COG1988	membrane-bound metal-dependent
DA376_RS15805	COG1368	sulfuric ester hydrolase activity
DA376_RS15810	COG1910	domain protein
DA376_RS15815	COG0725	ABC transporter, periplasmic molybdate-binding protein
DA376_RS15820	COG4149	molybdate abc transporter
DA376_RS15825	COG2197	response regulator
DA376_RS15830	COG3850	Histidine kinase
DA376_RS15835	COG1131	(ABC) transporter
DA376_RS15845	COG0842	Transport permease protein
DA376_RS15850	COG0656	L-ascorbic acid biosynthetic process
DA376_RS15875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA376_RS15880	COG3973	AAA domain
DA376_RS15885	COG2860	membrane
DA376_RS15895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DA376_RS15900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA376_RS15905	COG2217	Heavy metal translocating P-type atpase
DA376_RS15910	COG2217	Heavy metal translocating P-type atpase
DA376_RS15915	COG2608	mercury ion transmembrane transporter activity
DA376_RS15920	COG1937	Protein conserved in bacteria
DA376_RS15925	COG0673	inositol 2-dehydrogenase activity
DA376_RS15935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS15940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA376_RS15945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS15950	COG1126	abc transporter atp-binding protein
DA376_RS15955	COG0765	amino acid transport
DA376_RS15960	COG0765	amino acid transport
DA376_RS15965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA376_RS15970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA376_RS15975	COG0454	-acetyltransferase
DA376_RS15980	COG0583	DNA-binding transcription factor activity
DA376_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS16035	COG0557	exoribonuclease II activity
DA376_RS16040	COG1647	Serine aminopeptidase, S33
DA376_RS16045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA376_RS16050	COG1476	TRANSCRIPTIONal
DA376_RS16055	COG1396	sequence-specific DNA binding
DA376_RS16060	COG1396	sequence-specific DNA binding
DA376_RS16065	COG1733	regulation of RNA biosynthetic process
DA376_RS16090	COG1131	(ABC) transporter
DA376_RS16095	COG1174	glycine betaine transport
DA376_RS16100	COG1732	Glycine betaine
DA376_RS16105	COG1174	glycine betaine transport
DA376_RS16110	COG1125	glycine betaine transport
DA376_RS16110	COG0517	IMP dehydrogenase activity
DA376_RS16115	COG1510	regulation of RNA biosynthetic process
DA376_RS16120	COG1174	glycine betaine transport
DA376_RS16125	COG1732	Glycine betaine
DA376_RS16130	COG1174	glycine betaine transport
DA376_RS16135	COG0517	IMP dehydrogenase activity
DA376_RS16135	COG1125	glycine betaine transport
DA376_RS16140	COG1510	regulation of RNA biosynthetic process
DA376_RS16145	COG2095	MarC family integral membrane protein
DA376_RS16150	COG3064	Membrane
DA376_RS16155	COG4640	response to antibiotic
DA376_RS16160	COG0456	acetyltransferase
DA376_RS16175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA376_RS16195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA376_RS16200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA376_RS16210	COG2234	aminopeptidase activity
DA376_RS16230	COG0126	phosphoglycerate kinase activity
DA376_RS16240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA376_RS16245	COG2390	Transcriptional regulator
DA376_RS16250	COG2814	Major facilitator Superfamily
DA376_RS16255	COG1609	Transcriptional regulator
DA376_RS16260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS16270	COG0583	DNA-binding transcription factor activity
DA376_RS16275	COG0697	spore germination
DA376_RS16280	COG1113	amino acid transport
DA376_RS16290	COG1609	Transcriptional regulator
DA376_RS16300	COG0561	phosphatase activity
DA376_RS16305	COG1737	Transcriptional regulator
DA376_RS16310	COG1070	Carbohydrate kinase
DA376_RS16350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS16355	COG2186	Transcriptional regulator
DA376_RS16360	COG1620	l-lactate permease
DA376_RS16365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DA376_RS16375	COG5039	Polysaccharide pyruvyl transferase
DA376_RS16380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA376_RS16385	COG0110	maltose O-acetyltransferase activity
DA376_RS16390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA376_RS16395	COG2244	polysaccharide biosynthetic process
DA376_RS16400	COG1216	Glycosyl transferase, family 2
DA376_RS16405	COG5039	Polysaccharide pyruvyl transferase
DA376_RS16410	COG1216	Glycosyl transferase, family 2
DA376_RS16420	COG0438	transferase activity, transferring glycosyl groups
DA376_RS16425	COG1215	transferase activity, transferring glycosyl groups
DA376_RS16430	COG0438	transferase activity, transferring glycosyl groups
DA376_RS16435	COG1086	Polysaccharide biosynthesis protein
DA376_RS16440	COG0489	protein tyrosine kinase activity
DA376_RS16445	COG3944	biosynthesis protein
DA376_RS16450	COG1396	sequence-specific DNA binding
DA376_RS16455	COG2272	Belongs to the type-B carboxylesterase lipase family
DA376_RS16460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA376_RS16465	COG2364	Membrane
DA376_RS16470	COG0456	acetyltransferase
DA376_RS16475	COG3479	Phenolic acid decarboxylase
DA376_RS16525	COG2223	nitrite transmembrane transporter activity
DA376_RS16530	COG1609	Transcriptional regulator
DA376_RS16540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA376_RS16545	COG0366	Alpha amylase catalytic
DA376_RS16550	COG1554	hydrolase, family 65, central catalytic
DA376_RS16555	COG5521	maltodextrose utilization protein MalA
DA376_RS16560	COG3833	ABC-type maltose transport systems, permease component
DA376_RS16565	COG1175	transmembrane transport
DA376_RS16570	COG2182	Extracellular solute-binding protein
DA376_RS16575	COG0366	Alpha amylase catalytic
DA376_RS16580	COG1609	Transcriptional regulator
DA376_RS16585	COG1611	Belongs to the LOG family
DA376_RS16590	COG1694	Mazg nucleotide pyrophosphohydrolase
DA376_RS16595	COG0659	secondary active sulfate transmembrane transporter activity
DA376_RS16600	COG0288	reversible hydration of carbon dioxide
DA376_RS16610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA376_RS16615	COG4290	ribonuclease
DA376_RS16620	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DA376_RS16625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS16635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA376_RS16645	COG1051	belongs to the nudix hydrolase family
DA376_RS16650	COG0492	ferredoxin-NADP+ reductase activity
DA376_RS16655	COG3883	PFAM NLP P60 protein
DA376_RS16655	COG0791	NLP P60 protein
DA376_RS16660	COG0457	Tetratricopeptide repeat
DA376_RS16665	COG5002	protein histidine kinase activity
DA376_RS16670	COG0745	RESPONSE REGULATOR receiver
DA376_RS16675	COG1132	(ABC) transporter
DA376_RS16680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DA376_RS16680	COG0140	phosphoribosyl-ATP diphosphatase activity
DA376_RS16705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DA376_RS16720	COG4990	cell redox homeostasis
DA376_RS16725	COG0110	maltose O-acetyltransferase activity
DA376_RS16745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA376_RS16755	COG2188	Transcriptional regulator
DA376_RS16760	COG1309	transcriptional regulator
DA376_RS16765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DA376_RS16770	COG1950	PFAM Membrane protein of
DA376_RS16775	COG1983	PspC domain protein
DA376_RS16780	COG3595	metallopeptidase activity
DA376_RS16795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA376_RS16805	COG4897	Protein conserved in bacteria
DA376_RS16810	COG0574	Belongs to the PEP-utilizing enzyme family
DA376_RS16810	COG3848	Pyruvate phosphate dikinase
DA376_RS16815	COG1309	transcriptional regulator
DA376_RS16820	COG2814	Major facilitator Superfamily
DA376_RS16835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA376_RS16845	COG0793	Belongs to the peptidase S41A family
DA376_RS16845	COG3409	Peptidoglycan-binding domain 1 protein
DA376_RS16850	COG3420	alginic acid biosynthetic process
DA376_RS16855	COG2177	Part of the ABC transporter FtsEX involved in
DA376_RS16860	COG2884	Cell division ATP-binding protein ftsE
DA376_RS16865	COG2010	Cytochrome c
DA376_RS16870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS16885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA376_RS16900	COG1516	flagellar protein fliS
DA376_RS16905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DA376_RS16910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA376_RS16930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA376_RS16935	COG1256	bacterial-type flagellum assembly
DA376_RS16935	COG4786	Flagellar basal body rod
DA376_RS16940	COG3418	PFAM FlgN family protein
DA376_RS16945	COG2747	anti-sigma28 factor FlgM
DA376_RS16955	COG1040	competence protein
DA376_RS16965	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DA376_RS16970	COG1307	EDD domain protein, DegV family
DA376_RS16975	COG2197	response regulator
DA376_RS16980	COG4585	Histidine kinase
DA376_RS16985	COG1739	Uncharacterized protein family UPF0029
DA376_RS16990	COG1316	TRANSCRIPTIONal
DA376_RS16995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA376_RS17000	COG0438	transferase activity, transferring glycosyl groups
DA376_RS17005	COG1215	transferase activity, transferring glycosyl groups
DA376_RS17010	COG3206	protein involved in exopolysaccharide biosynthesis
DA376_RS17015	COG3307	-O-antigen
DA376_RS17020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA376_RS17025	COG0297	glycogen (starch) synthase activity
DA376_RS17025	COG0438	transferase activity, transferring glycosyl groups
DA376_RS17030	COG2244	polysaccharide biosynthetic process
DA376_RS17040	COG2247	cell wall binding repeat
DA376_RS17040	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA376_RS17045	COG2247	cell wall binding repeat
DA376_RS17045	COG2385	sporulation resulting in formation of a cellular spore
DA376_RS17055	COG1316	TRANSCRIPTIONal
DA376_RS17060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DA376_RS17065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA376_RS17070	COG1134	teichoic acid transport
DA376_RS17075	COG1682	transport, permease protein
DA376_RS17080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA376_RS17090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DA376_RS17095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DA376_RS17100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA376_RS17105	COG4193	domain, Protein
DA376_RS17110	COG1482	cell wall glycoprotein biosynthetic process
DA376_RS17115	COG0697	spore germination
DA376_RS17120	COG0814	amino acid
DA376_RS17130	COG1215	transferase activity, transferring glycosyl groups
DA376_RS17135	COG2814	Major facilitator Superfamily
DA376_RS17140	COG1316	TRANSCRIPTIONal
DA376_RS17145	COG0561	phosphatase activity
DA376_RS17150	COG2433	Pfam Transposase IS66
DA376_RS17155	COG0791	NLP P60 protein
DA376_RS17165	COG2843	Capsule synthesis protein
DA376_RS17175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DA376_RS17185	COG0697	spore germination
DA376_RS17190	COG0814	amino acid
DA376_RS17200	COG1609	Transcriptional regulator
DA376_RS17205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA376_RS17215	COG1129	ABC transporter
DA376_RS17220	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA376_RS17225	COG1879	ABC-type sugar transport system periplasmic component
DA376_RS17230	COG3103	Sh3 type 3 domain protein
DA376_RS17235	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA376_RS17240	COG3527	Alpha-acetolactate decarboxylase
DA376_RS17245	COG0028	Belongs to the TPP enzyme family
DA376_RS17250	COG0583	DNA-binding transcription factor activity
DA376_RS17255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA376_RS17270	COG5337	Spore coat protein CotH
DA376_RS17280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA376_RS17290	COG0405	Gamma-glutamyltransferase
DA376_RS17295	COG1522	sequence-specific DNA binding
DA376_RS17300	COG2059	Chromate
DA376_RS17305	COG2059	Chromate
DA376_RS17315	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA376_RS17320	COG0583	DNA-binding transcription factor activity
DA376_RS17355	COG5444	nuclease activity
DA376_RS17370	COG3878	Protein conserved in bacteria
DA376_RS17375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA376_RS17380	COG4464	protein tyrosine phosphatase activity
DA376_RS17385	COG0489	protein tyrosine kinase activity
DA376_RS17390	COG3944	biosynthesis protein
DA376_RS17405	COG4715	Zinc finger, swim domain protein
DA376_RS17410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA376_RS17415	COG0561	phosphatase activity
DA376_RS17420	COG1349	DNA-binding transcription factor activity
DA376_RS17425	COG0629	single-stranded DNA binding
DA376_RS17450	COG0457	Tetratricopeptide repeat
DA376_RS17455	COG4786	Flagellar basal body rod
DA376_RS17460	COG4786	Flagellar basal body rod
DA376_RS17465	COG1077	Cell shape determining protein MreB Mrl
DA376_RS17470	COG1609	Transcriptional regulator
DA376_RS17475	COG1846	Transcriptional regulator
DA376_RS17480	COG2814	Major facilitator Superfamily
DA376_RS17485	COG1953	Uracil, thiamine, allantoin
DA376_RS17490	COG0477	Major facilitator Superfamily
DA376_RS17495	COG1335	isochorismatase
DA376_RS17500	COG0004	ammonium transporteR
DA376_RS17505	COG0347	Belongs to the P(II) protein family
DA376_RS17510	COG0772	Belongs to the SEDS family
DA376_RS17515	COG0671	phosphoesterase, PA-phosphatase related
DA376_RS17525	COG0739	heme binding
DA376_RS17530	COG1247	-acetyltransferase
DA376_RS17545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA376_RS17555	COG0726	polysaccharide deacetylase
DA376_RS17565	COG1959	2 iron, 2 sulfur cluster binding
DA376_RS17580	COG0831	urea catabolic process
DA376_RS17585	COG3237	CsbD-like
DA376_RS17590	COG1994	Peptidase M50
DA376_RS17595	COG0457	Tetratricopeptide repeat
DA376_RS17605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA376_RS17610	COG2304	oxidoreductase activity
DA376_RS17615	COG2304	oxidoreductase activity
DA376_RS17625	COG2385	sporulation resulting in formation of a cellular spore
DA376_RS17630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA376_RS17640	COG4836	Membrane
DA376_RS17710	COG0698	ribose 5-phosphate isomerase
DA376_RS17715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA376_RS17725	COG0009	L-threonylcarbamoyladenylate synthase
DA376_RS17730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA376_RS17750	COG2890	protein-(glutamine-N5) methyltransferase activity
DA376_RS17755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA376_RS17760	COG0346	lactoylglutathione lyase activity
DA376_RS17765	COG0789	Transcriptional regulator
DA376_RS17770	COG0679	Auxin Efflux Carrier
DA376_RS17775	COG0281	malic enzyme
DA376_RS17790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA376_RS17795	COG1494	fructose-1,6-bisphosphatase
DA376_RS17800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA376_RS17815	COG0191	fructose-bisphosphate aldolase activity
DA376_RS17820	COG2204	response regulator
DA376_RS17825	COG4821	SIS domain
DA376_RS17840	COG2181	nitrate reductase activity
DA376_RS17840	COG0247	lactate metabolic process
DA376_RS17845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA376_RS17860	COG1132	(ABC) transporter
DA376_RS17865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA376_RS17875	COG2181	nitrate reductase activity
DA376_RS17880	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DA376_RS17885	COG1140	nitrate reductase beta subunit
DA376_RS17890	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DA376_RS17895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA376_RS17905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA376_RS17910	COG2223	nitrite transmembrane transporter activity
DA376_RS17920	COG4506	Protein conserved in bacteria
DA376_RS17930	COG3391	amine dehydrogenase activity
DA376_RS17935	COG3391	amine dehydrogenase activity
DA376_RS17945	COG0457	Tetratricopeptide repeat
DA376_RS17955	COG0010	Belongs to the arginase family
DA376_RS17960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA376_RS17965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA376_RS17980	COG1994	Peptidase M50
DA376_RS17985	COG1942	4-Oxalocrotonate Tautomerase
DA376_RS17990	COG1846	Transcriptional regulator
DA376_RS18000	COG0531	amino acid
DA376_RS18005	COG3465	dGTPase activity
DA376_RS18010	COG1078	dGTPase activity
DA376_RS18025	COG1695	Transcriptional regulator
DA376_RS18035	COG1131	(ABC) transporter
DA376_RS18040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA376_RS18070	COG0583	DNA-binding transcription factor activity
DA376_RS18075	COG2855	membrane
DA376_RS18080	COG0280	phosphate acetyltransferase
DA376_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS18095	COG0436	Aminotransferase
DA376_RS18125	COG2814	Major facilitator Superfamily
DA376_RS18130	COG2814	Major facilitator Superfamily
DA376_RS18135	COG0833	amino acid
DA376_RS18140	COG4187	Peptidase family M20/M25/M40
DA376_RS18145	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS18150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA376_RS18155	COG2205	protein histidine kinase activity
DA376_RS18160	COG0745	RESPONSE REGULATOR receiver
DA376_RS18175	COG1131	(ABC) transporter
DA376_RS18180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DA376_RS18185	COG1091	dTDP-4-dehydrorhamnose reductase activity
DA376_RS18190	COG1088	dTDP-glucose 4,6-dehydratase activity
DA376_RS18195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DA376_RS18200	COG3980	spore coat polysaccharide biosynthesis protein
DA376_RS18205	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DA376_RS18210	COG2089	acid synthase
DA376_RS18215	COG0456	acetyltransferase
DA376_RS18220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA376_RS18230	COG0463	Glycosyl transferase, family 2
DA376_RS18240	COG2363	Small membrane protein
DA376_RS18245	COG2233	PERMEase
DA376_RS18260	COG1216	Glycosyl transferase, family 2
DA376_RS18275	COG1695	Transcriptional regulator
DA376_RS18280	COG0351	phosphomethylpyrimidine kinase
DA376_RS18290	COG1621	beta-fructofuranosidase activity
DA376_RS18295	COG1263	PTS System
DA376_RS18295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA376_RS18300	COG3711	transcriptional antiterminator
DA376_RS18310	COG1404	Belongs to the peptidase S8 family
DA376_RS18315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA376_RS18320	COG0778	Nitroreductase
DA376_RS18325	COG0772	Belongs to the SEDS family
DA376_RS18330	COG0454	-acetyltransferase
DA376_RS18350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA376_RS18355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA376_RS18360	COG2261	transglycosylase associated protein
DA376_RS18365	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DA376_RS18370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA376_RS18375	COG2246	polysaccharide biosynthetic process
DA376_RS18380	COG1309	transcriptional regulator
DA376_RS18400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DA376_RS18405	COG2837	iron assimilation
DA376_RS18420	COG0583	DNA-binding transcription factor activity
DA376_RS18430	COG1346	cytolysis
DA376_RS18435	COG4895	conserved protein (DUF2196)
DA376_RS18440	COG0789	Transcriptional regulator
DA376_RS18445	COG5504	Zn-dependent protease
DA376_RS18450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA376_RS18455	COG0346	lactoylglutathione lyase activity
DA376_RS18460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS18465	COG1404	Belongs to the peptidase S8 family
DA376_RS18470	COG1442	glycosyl transferase family 8
DA376_RS18475	COG2357	RelA SpoT domain protein
DA376_RS18480	COG1575	Belongs to the MenA family. Type 1 subfamily
DA376_RS18500	COG1696	Membrane protein involved in D-alanine export
DA376_RS18510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DA376_RS18515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA376_RS18520	COG1486	melibiose metabolic process
DA376_RS18525	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA376_RS18530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS18535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS18540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA376_RS18540	COG3711	transcriptional antiterminator
DA376_RS18555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS18560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA376_RS18570	COG0640	Transcriptional regulator
DA376_RS18575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA376_RS18580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS18585	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA376_RS18590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA376_RS18595	COG2723	6-phospho-beta-galactosidase activity
DA376_RS18605	COG1482	cell wall glycoprotein biosynthetic process
DA376_RS18615	COG0753	catalase activity
DA376_RS18620	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DA376_RS18625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA376_RS18645	COG3279	Response regulator of the LytR AlgR family
DA376_RS18665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA376_RS18670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DA376_RS18675	COG4988	ABC transporter
DA376_RS18680	COG1294	oxidase, subunit
DA376_RS18685	COG1271	oxidase subunit
DA376_RS18690	COG3493	citrate carrier protein
DA376_RS18695	COG0726	polysaccharide deacetylase
DA376_RS18700	COG3842	ATPase activity
DA376_RS18705	COG2508	Transcriptional regulator
DA376_RS18710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS18720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA376_RS18730	COG4894	glucomannan catabolic process
DA376_RS18735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA376_RS18740	COG0500	methyltransferase
DA376_RS18745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA376_RS18760	COG0693	protein deglycase activity
DA376_RS18760	COG0753	catalase activity
DA376_RS18765	COG2851	Citrate transporter
DA376_RS18770	COG2273	Hydrolase Family 16
DA376_RS18780	COG2270	Major facilitator Superfamily
DA376_RS18785	COG0513	Belongs to the DEAD box helicase family
DA376_RS18795	COG0697	spore germination
DA376_RS18800	COG0589	response to stress
DA376_RS18850	COG3507	Belongs to the glycosyl hydrolase 43 family
DA376_RS18880	COG0010	Belongs to the arginase family
DA376_RS18885	COG0833	amino acid
DA376_RS18890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DA376_RS18895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA376_RS18905	COG2390	Transcriptional regulator
DA376_RS18910	COG0561	phosphatase activity
DA376_RS18940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA376_RS18945	COG5294	Protein conserved in bacteria
DA376_RS18950	COG0577	efflux transmembrane transporter activity
DA376_RS18955	COG1136	(ABC) transporter
DA376_RS18960	COG2205	protein histidine kinase activity
DA376_RS18965	COG0745	RESPONSE REGULATOR receiver
DA376_RS18970	COG2205	protein histidine kinase activity
DA376_RS18975	COG0745	RESPONSE REGULATOR receiver
DA376_RS19005	COG1082	Xylose isomerase domain protein TIM barrel
DA376_RS19015	COG2814	Major facilitator Superfamily
DA376_RS19045	COG1349	DNA-binding transcription factor activity
DA376_RS19050	COG0667	Aldo Keto reductase
DA376_RS19055	COG2814	Major facilitator Superfamily
DA376_RS19070	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS19075	COG2197	response regulator
DA376_RS19080	COG4585	Histidine kinase
DA376_RS19085	COG3239	Fatty acid desaturase
DA376_RS19090	COG1309	transcriptional regulator
DA376_RS19095	COG1012	belongs to the aldehyde dehydrogenase family
DA376_RS19100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA376_RS19110	COG0640	Transcriptional regulator
DA376_RS19115	COG2814	Major facilitator Superfamily
DA376_RS19120	COG1714	RDD family
DA376_RS19130	COG0450	alkyl hydroperoxide reductase
DA376_RS19135	COG3634	alkyl hydroperoxide reductase activity
DA376_RS19140	COG3177	Filamentation induced by cAMP protein fic
DA376_RS19145	COG1113	amino acid transport
DA376_RS19155	COG2080	2 iron, 2 sulfur cluster binding
DA376_RS19170	COG2068	MobA-Related Protein
DA376_RS19175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DA376_RS19230	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DA376_RS19235	COG0667	Aldo Keto reductase
DA376_RS19240	COG0456	acetyltransferase
DA376_RS19245	COG0457	Tetratricopeptide repeat
DA376_RS19250	COG0010	Belongs to the arginase family
DA376_RS19255	COG0833	amino acid
DA376_RS19260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA376_RS19265	COG5658	integral membrane protein
DA376_RS19270	COG0640	Transcriptional regulator
DA376_RS19275	COG3829	transcription factor binding
DA376_RS19285	COG0488	(ABC) transporter
DA376_RS19300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA376_RS19305	COG5002	protein histidine kinase activity
DA376_RS19305	COG3850	Histidine kinase
DA376_RS19310	COG0745	RESPONSE REGULATOR receiver
DA376_RS19315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA376_RS19320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DA376_RS19325	COG4853	Protein conserved in bacteria
DA376_RS19330	COG4863	YycH protein
DA376_RS19335	COG5002	protein histidine kinase activity
DA376_RS19340	COG0745	RESPONSE REGULATOR receiver
DA376_RS19375	COG0346	lactoylglutathione lyase activity
DA376_RS19380	COG0305	Participates in initiation and elongation during chromosome replication
DA376_RS19395	COG3093	addiction module antidote protein HigA
DA376_RS19400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA376_RS19405	COG0297	glycogen (starch) synthase activity
DA376_RS19415	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DA376_RS19420	COG0438	transferase activity, transferring glycosyl groups
DA376_RS19440	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DA376_RS19445	COG4241	membrane
DA376_RS19455	COG5577	PFAM Coat F domain
DA376_RS19460	COG1733	regulation of RNA biosynthetic process
DA376_RS19470	COG0697	spore germination
DA376_RS19475	COG1621	beta-fructofuranosidase activity
DA376_RS19480	COG1621	beta-fructofuranosidase activity
DA376_RS19490	COG2318	DinB family
DA376_RS19495	COG2211	Major facilitator Superfamily
DA376_RS19505	COG0778	Nitroreductase
DA376_RS19510	COG1846	Transcriptional regulator
DA376_RS19515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA376_RS19520	COG1846	Transcriptional regulator
DA376_RS19525	COG2153	protein acetylation
DA376_RS19535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA376_RS19540	COG0583	DNA-binding transcription factor activity
DA376_RS19545	COG1028	Short-chain dehydrogenase reductase Sdr
DA376_RS19550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA376_RS19555	COG0697	spore germination
DA376_RS19560	COG1331	Highly conserved protein containing a thioredoxin domain
DA376_RS19585	COG1331	Highly conserved protein containing a thioredoxin domain
DA376_RS19590	COG1266	CAAX protease self-immunity
DA376_RS19595	COG0477	Major facilitator Superfamily
DA376_RS19595	COG2814	Major facilitator Superfamily
DA376_RS19600	COG0346	lactoylglutathione lyase activity
DA376_RS19605	COG1609	Transcriptional regulator
DA376_RS19610	COG0708	Exodeoxyribonuclease III
DA376_RS19615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated