locus-tag class description HNO13_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HNO13_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HNO13_RS00015 ENOG410848D S4 domain protein YaaA HNO13_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HNO13_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNO13_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNO13_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HNO13_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HNO13_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HNO13_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HNO13_RS00095 ENOG4105BZW Glycerate kinase HNO13_RS00105 ENOG4105ZMH deoxynucleoside kinase HNO13_RS00115 ENOG4105VRS hydrolase family 18 HNO13_RS00120 ENOG4105GTG Isochorismatase HNO13_RS00125 ENOG4108Z6B deaminase HNO13_RS00135 ENOG4105C6E dna polymerase iii HNO13_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HNO13_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HNO13_RS00155 ENOG41067KS pro-sigma K processing HNO13_RS00195 ENOG4105CDW Resistance protein HNO13_RS00200 ENOG4105CXN decarboxylase HNO13_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HNO13_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II HNO13_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) HNO13_RS00220 ENOG4105FA2 dna polymerase iii HNO13_RS00225 ENOG4105MA4 psp1 domain protein HNO13_RS00235 ENOG41060K3 Methyltransferase HNO13_RS00240 ENOG4105VC4 domain protein HNO13_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HNO13_RS00250 ENOG4105KRN Transcriptional regulator, abrb family HNO13_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HNO13_RS00260 ENOG4105F8V Hydrolase, tatD family HNO13_RS00265 ENOG41069ER domain protein HNO13_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HNO13_RS00280 ENOG4105XFA sporulation peptidase YabG HNO13_RS00285 ENOG4105W42 Veg protein HNO13_RS00290 ENOG4105XEW small acid-soluble spore protein HNO13_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HNO13_RS00300 ENOG4105DFT pur operon repressor HNO13_RS00305 ENOG4105KME endoribonuclease L-psp HNO13_RS00310 ENOG4105K4W Could be involved in septation (By similarity) HNO13_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HNO13_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HNO13_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HNO13_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor HNO13_RS00345 ENOG4108M14 stage v sporulation protein t HNO13_RS00355 ENOG4108IY2 MazG family HNO13_RS00360 ENOG41082I2 s4 domain protein HNO13_RS00365 ENOG4105VYY sporulation protein yabp HNO13_RS00380 ENOG41060GV RNA binding s1 domain protein HNO13_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HNO13_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase HNO13_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HNO13_RS00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HNO13_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HNO13_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HNO13_RS00440 ENOG4105C6T cysteine synthase HNO13_RS00445 ENOG4105CRQ synthase (Component I) HNO13_RS00450 ENOG4105DDQ anthranilate synthase HNO13_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HNO13_RS00460 ENOG4105EEI dihydropteroate synthase HNO13_RS00465 ENOG4105KRF dihydroneopterin aldolase HNO13_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HNO13_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HNO13_RS00485 ENOG4105CRK lysyL-tRNA synthetase HNO13_RS00570 ENOG4108Z0C Uvrb UvrC protein HNO13_RS00575 ENOG41066A3 ATP guanido phosphotransferase HNO13_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HNO13_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HNO13_RS00595 ENOG4105CTP PilT protein domain protein HNO13_RS00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HNO13_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HNO13_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HNO13_RS00615 ENOG4105D7W serine acetyltransferase HNO13_RS00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HNO13_RS00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 HNO13_RS00635 ENOG4105M0M Tetracycline resistance protein HNO13_RS00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HNO13_RS00670 ENOG4108VZM 50s ribosomal protein L10 HNO13_RS00680 ENOG4107Y49 methyltransferase HNO13_RS00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HNO13_RS00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HNO13_RS00695 ENOG4105XPM ribosomal protein HNO13_RS00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HNO13_RS00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HNO13_RS00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HNO13_RS00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HNO13_RS00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HNO13_RS00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HNO13_RS00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HNO13_RS00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HNO13_RS00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HNO13_RS00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HNO13_RS00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HNO13_RS00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HNO13_RS00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HNO13_RS00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HNO13_RS00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HNO13_RS00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HNO13_RS00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HNO13_RS00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HNO13_RS00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HNO13_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HNO13_RS00850 ENOG41067V7 50S ribosomal protein L36 HNO13_RS00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HNO13_RS00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HNO13_RS00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HNO13_RS00870 ENOG4108ZT0 50S ribosomal protein l17 HNO13_RS00875 ENOG4108JJB ABC transporter HNO13_RS00880 ENOG4108JJB ABC transporter HNO13_RS00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HNO13_RS00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HNO13_RS00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HNO13_RS00900 ENOG4108UJD 30S ribosomal protein S9 HNO13_RS00905 ENOG4108I0C methyltransferase HNO13_RS00925 ENOG4105D1F ATP-binding protein HNO13_RS00940 ENOG4108NMV polysaccharide deacetylase HNO13_RS01005 ENOG4108JPW Aminotransferase HNO13_RS01015 ENOG4105CPQ Dehydrogenase HNO13_RS01020 ENOG4105CHH sulfate transporter HNO13_RS01030 ENOG4108SA1 esterase HNO13_RS01050 ENOG410874W AraC family transcriptional regulator HNO13_RS01055 ENOG4105EHZ conserved protein UCP016719 HNO13_RS01060 ENOG4105D17 glycoside hydrolase, family 3 domain protein HNO13_RS01075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HNO13_RS01085 ENOG4105EWC Purine nucleoside phosphorylase HNO13_RS01115 ENOG4105EMN RNA polymerase sigma factor HNO13_RS01125 ENOG4105C8B TIGR00159 family HNO13_RS01130 ENOG4107U5W ybbr family HNO13_RS01135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HNO13_RS01160 ENOG4106K80 HNO13_RS01170 ENOG41067MG lrgb family HNO13_RS01180 ENOG41061AU MarR family Transcriptional regulator HNO13_RS01195 ENOG4105BZU Histidine kinase HNO13_RS01200 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS01205 ENOG4105CJ1 ABC, transporter HNO13_RS01245 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS01250 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS01275 ENOG4106DDH Sporulation-specific SASP protein HNO13_RS01290 ENOG4107QTZ amino acid HNO13_RS01295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HNO13_RS01300 ENOG4105CXY transporter HNO13_RS01335 ENOG4107SCQ Iron-containing alcohol dehydrogenase HNO13_RS01340 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HNO13_RS01345 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HNO13_RS01350 ENOG4107ZTW SNARE associated Golgi HNO13_RS01365 ENOG4105C72 UPF0176 protein HNO13_RS01375 ENOG4105CM2 brancheD-chain amino acid aminotransferase HNO13_RS01380 ENOG4108IQI permease HNO13_RS01385 ENOG4108J5H Homocysteine s-methyltransferase HNO13_RS01395 ENOG4105CSV Glutaminase HNO13_RS01420 ENOG41076HS cation diffusion facilitator family transporter HNO13_RS01425 ENOG4108TVJ Nitroreductase HNO13_RS01430 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HNO13_RS01435 ENOG4108VGI doxx family HNO13_RS01440 ENOG4105XXY Thioredoxin HNO13_RS01455 ENOG4105DGI Alkaline phosphatase HNO13_RS01460 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HNO13_RS01465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HNO13_RS01470 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HNO13_RS01475 ENOG4107EPV Aminotransferase class V HNO13_RS01480 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNO13_RS01485 ENOG4105J7D transcriptional regulator HNO13_RS01490 ENOG4107RB3 L-asparaginase HNO13_RS01495 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HNO13_RS01500 ENOG41060AI SEC-C motif HNO13_RS01505 ENOG4107SET aldo keto reductase HNO13_RS01535 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HNO13_RS01545 ENOG4105DSE periplasmic solute binding protein HNO13_RS01550 ENOG4105DIK (ABC) transporter HNO13_RS01560 ENOG4105DEN Luciferase family HNO13_RS01565 ENOG4108N0M stress protein HNO13_RS01570 ENOG4106FN3 tellurium resistance protein HNO13_RS01575 ENOG4106FN3 tellurium resistance protein HNO13_RS01580 ENOG4107TS3 membrane protein, TerC HNO13_RS01585 ENOG4108TTB tellurium resistance protein HNO13_RS01595 ENOG41079KZ Major Facilitator Superfamily HNO13_RS01600 ENOG4108IJ7 Glycine betaine HNO13_RS01605 ENOG4107SQ8 Glycine betaine HNO13_RS01635 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HNO13_RS01665 ENOG4105EIG urea carboxylase-associated protein 1 HNO13_RS01670 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HNO13_RS01680 ENOG4105I1F Resistance protein HNO13_RS01690 ENOG4105DJB Major Facilitator Superfamily HNO13_RS01695 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HNO13_RS01700 ENOG4105I82 acetyl xylan esterase HNO13_RS01705 ENOG410756H nucleotidyltransferase HNO13_RS01715 ENOG4105C26 Dehydrogenase HNO13_RS01720 ENOG4105CK7 Sodium proline symporter HNO13_RS01725 ENOG4107YHD transcriptional regulator HNO13_RS01730 ENOG4105CAY ferredoxin--nadp reductase HNO13_RS01735 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HNO13_RS01740 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HNO13_RS01745 ENOG4108IFG nitrite reductase, (NAD(P)H) HNO13_RS01750 ENOG4105CKI cobalamin synthesis protein HNO13_RS01755 ENOG4105E2A Dehydrogenase HNO13_RS01760 ENOG4105HHM rdd domain containing protein HNO13_RS01770 ENOG4105CS2 ec 3.2.1.21 HNO13_RS01790 ENOG41080HJ 6-phospho 3-hexuloisomerase HNO13_RS01795 ENOG4108VA3 3-hexulose-6-phosphate synthase HNO13_RS01800 ENOG4105KVH Transcriptional regulator HNO13_RS01805 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS01825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HNO13_RS01840 ENOG4105CDA abc transporter atp-binding protein HNO13_RS01845 ENOG4105DRP amino acid AbC transporter HNO13_RS01855 ENOG4106P55 Transcriptional regulator HNO13_RS01860 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HNO13_RS01865 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HNO13_RS01870 ENOG41069ZX HNO13_RS01875 ENOG41069ZX HNO13_RS01880 ENOG4105DUX Transporter HNO13_RS01895 ENOG4105E1K spore germination protein HNO13_RS01920 ENOG4105EAB amino acid AbC transporter HNO13_RS01925 ENOG4108HW4 amino acid AbC transporter HNO13_RS01940 ENOG4108PGP mmge prpd family protein HNO13_RS01950 ENOG4107WD8 ABC transporter, permease HNO13_RS01955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS01960 ENOG4105BZU Histidine kinase HNO13_RS01980 ENOG4105CFH Aspartokinase HNO13_RS01985 ENOG4105DHS permease protein HNO13_RS01990 ENOG4105CM4 permease protein HNO13_RS01995 ENOG4108IPW abc transporter atp-binding protein HNO13_RS02010 ENOG4105R8C Transcriptional regulator HNO13_RS02015 ENOG4108DBC nitroreductase HNO13_RS02020 ENOG41067V3 Antibiotic biosynthesis monooxygenase HNO13_RS02025 ENOG4105YVS arsR family transcriptional regulator HNO13_RS02035 ENOG4108JPW Aminotransferase HNO13_RS02040 ENOG4105C26 Dehydrogenase HNO13_RS02050 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HNO13_RS02055 ENOG4105KTB nuclear export factor GLE1 HNO13_RS02060 ENOG4108T5E Copper resistance protein HNO13_RS02065 ENOG4108ZYE Transcriptional regulator HNO13_RS02085 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HNO13_RS02105 ENOG4105E7W lamb ycsf family protein HNO13_RS02110 ENOG4105C5A transporter HNO13_RS02115 ENOG4105CFM UPF0317 protein HNO13_RS02120 ENOG4105P4J Allophanate hydrolase, subunit 1 HNO13_RS02130 ENOG4107258 Transcriptional regulator HNO13_RS02135 ENOG4105XJB lipolytic protein G-D-S-L family HNO13_RS02145 ENOG41061CK Antibiotic biosynthesis monooxygenase HNO13_RS02150 ENOG4107RVG penicillin-binding protein HNO13_RS02155 ENOG4107QM2 Aldo Keto reductase HNO13_RS02160 ENOG4105ETD TRANSCRIPTIONal HNO13_RS02170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HNO13_RS02185 ENOG410606W general stress protein HNO13_RS02195 ENOG4105VCH membrane HNO13_RS02205 ENOG4105C9U ATP-dependent DNA helicase RecQ HNO13_RS02220 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HNO13_RS02225 ENOG4107R8N Glycosyl transferase, family 2 HNO13_RS02235 ENOG4105C0X amino acid HNO13_RS02270 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HNO13_RS02280 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HNO13_RS02285 ENOG4105RXJ HNO13_RS02290 ENOG4105KPY Small multidrug resistance protein HNO13_RS02295 ENOG4105EU9 HNO13_RS02300 ENOG4105QVS general stress protein HNO13_RS02305 ENOG41082W1 Cupin 2, conserved barrel domain protein HNO13_RS02320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HNO13_RS02325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HNO13_RS02330 ENOG4108MRH transcriptional regulatory protein HNO13_RS02335 ENOG4107QJT sodium dicarboxylate symporter HNO13_RS02340 ENOG4106F5Q Membrane HNO13_RS02345 ENOG4105CJ1 ABC, transporter HNO13_RS02360 ENOG4105FDT acyl-CoA dehydrogenase HNO13_RS02380 ENOG4105SZ6 Thioredoxin HNO13_RS02385 ENOG4105CPF Cell wall formation (By similarity) HNO13_RS02390 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HNO13_RS02395 ENOG4105C1J atp-dependent rna helicase HNO13_RS02400 ENOG410905X membrane-flanked domain protein HNO13_RS02405 ENOG4105CKV Membrane HNO13_RS02415 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HNO13_RS02420 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HNO13_RS02425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HNO13_RS02435 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HNO13_RS02440 ENOG4107MMM Anti-sigma-factor antagonist HNO13_RS02445 ENOG4105FUA antagonist HNO13_RS02450 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HNO13_RS02455 ENOG4107SGM protein serine threonine phosphatase HNO13_RS02460 ENOG4105WN5 stage II sporulation protein HNO13_RS02465 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HNO13_RS02475 ENOG41064BQ Phosphatase HNO13_RS02490 ENOG410906U SprT-like HNO13_RS02535 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HNO13_RS02550 ENOG4105C94 Transporter HNO13_RS02555 ENOG4105CSH Transporter HNO13_RS02570 ENOG4105K56 Transcriptional regulator HNO13_RS02580 ENOG4108Z40 Transcriptional regulator HNO13_RS02585 ENOG4108RYK Nad-dependent epimerase dehydratase HNO13_RS02590 ENOG4105VEQ Cold shock protein HNO13_RS02595 ENOG4108VJ1 Transcriptional regulator (CarD family HNO13_RS02600 ENOG4105XTG Pfam:DUF156 HNO13_RS02605 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HNO13_RS02615 ENOG4105VFE sira family HNO13_RS02620 ENOG4107TPS domain protein HNO13_RS02625 ENOG4105VFE sira family HNO13_RS02630 ENOG41087NI Sulfite exporter TauE/SafE HNO13_RS02650 ENOG4105IRW patatin-like phospholipase family protein HNO13_RS02660 ENOG4107RCH Diaminopropionate ammonia-lyase HNO13_RS02665 ENOG4108WYP Transcriptional regulator HNO13_RS02670 ENOG4105KME endoribonuclease L-psp HNO13_RS02675 ENOG4105C44 Serine transporter HNO13_RS02680 ENOG4105CH2 amidohydrolase HNO13_RS02685 ENOG4108MCI Transcriptional regulator, ARAC family HNO13_RS02690 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HNO13_RS02695 ENOG4107U9B transcriptional regulator HNO13_RS02700 ENOG4105DXI Major Facilitator superfamily HNO13_RS02720 ENOG4105DNP FAD linked oxidase domain protein HNO13_RS02725 ENOG4105PGM cation diffusion facilitator family transporter HNO13_RS02730 ENOG4105H3G oxidoreductase HNO13_RS02745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HNO13_RS02770 ENOG4105DQ4 alcohol dehydrogenase HNO13_RS02775 ENOG4105VUF Transcriptional regulator HNO13_RS02785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HNO13_RS02795 ENOG4105EQ0 Major Facilitator superfamily HNO13_RS02800 ENOG4108JGH Tetr family transcriptional regulator HNO13_RS02815 ENOG4105E2A Dehydrogenase HNO13_RS02820 ENOG4105PGS Spore coat protein HNO13_RS02830 ENOG4105ENE Histidine kinase HNO13_RS02835 ENOG4108VB1 regulatoR HNO13_RS02840 ENOG4105EYF MMPL domain protein HNO13_RS02860 ENOG4108JYZ YitT family HNO13_RS02870 ENOG4105C2C drug resistance transporter, Bcr CflA HNO13_RS02875 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HNO13_RS02895 ENOG41090E6 transcriptional regulator MERR family HNO13_RS02910 ENOG4105F2W methyltransferase HNO13_RS02915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HNO13_RS02920 ENOG4105DRR Transcriptional regulator, GntR family HNO13_RS02940 ENOG4105FQP Beta-lactamase HNO13_RS02950 ENOG41090UD (LipO)protein HNO13_RS02955 ENOG4108SUT Major Facilitator Superfamily HNO13_RS02960 ENOG4108TZY GntR Family Transcriptional Regulator HNO13_RS02965 ENOG4105JXH GntR family transcriptional regulator HNO13_RS02970 ENOG4105DJ2 Major Facilitator Superfamily HNO13_RS02990 ENOG4107QTZ amino acid HNO13_RS03010 ENOG4107QNK )-transporter HNO13_RS03050 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HNO13_RS03055 ENOG4105K8N protein family UPF0079, ATPase HNO13_RS03060 ENOG41072GX Peptidase M22 Glycoprotease HNO13_RS03065 ENOG410801F ribosomal-protein-alanine acetyltransferase HNO13_RS03070 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HNO13_RS03075 ENOG4105C5H ABC transporter HNO13_RS03080 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HNO13_RS03085 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HNO13_RS03090 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HNO13_RS03095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HNO13_RS03105 ENOG4108TYN CAAX amino terminal protease family protein HNO13_RS03115 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HNO13_RS03125 ENOG4105PGZ NB-ARC domain HNO13_RS03130 ENOG4105CPQ Dehydrogenase HNO13_RS03135 ENOG4105CT4 transporter HNO13_RS03150 ENOG41087YS Phage shock protein A HNO13_RS03155 ENOG4105DQX Zinc finger domain HNO13_RS03160 ENOG4108WV1 Pfam:DUF477 HNO13_RS03170 ENOG4105EXC Acyl-transferase HNO13_RS03175 ENOG4108P49 AntiSigma factor HNO13_RS03180 ENOG4105JVQ RNA Polymerase HNO13_RS03210 ENOG4107STQ Multicopper oxidase HNO13_RS03215 ENOG4105C85 amino acid HNO13_RS03220 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HNO13_RS03235 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HNO13_RS03250 ENOG4105C7N Xanthine uracil vitamin C permease HNO13_RS03275 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HNO13_RS03280 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HNO13_RS03285 ENOG4105C83 adenylosuccinate lyase HNO13_RS03290 ENOG4105C8V SAICAR synthetase HNO13_RS03295 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HNO13_RS03300 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HNO13_RS03305 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HNO13_RS03315 ENOG4105CXB phosphoribosylaminoimidazole synthetase HNO13_RS03320 ENOG4108V3E phosphoribosylglycinamide formyltransferase HNO13_RS03325 ENOG4105DC1 bifunctional purine biosynthesis protein purh HNO13_RS03330 ENOG4105C12 Phosphoribosylglycinamide synthetase HNO13_RS03345 ENOG4108R5T secreted protein HNO13_RS03350 ENOG4105KGF protein, YerC YecD HNO13_RS03355 ENOG4105CBC glutamate synthase HNO13_RS03365 ENOG4105C4R Atp-dependent dna helicase HNO13_RS03370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HNO13_RS03380 ENOG4105CRN Aminoglycoside phosphotransferase HNO13_RS03385 ENOG4105KT7 mgtC SapB transporter HNO13_RS03390 ENOG4105CK7 Sodium proline symporter HNO13_RS03395 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HNO13_RS03400 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HNO13_RS03405 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HNO13_RS03410 ENOG4108IG5 Transcriptional regulator HNO13_RS03420 ENOG4105CBD Diacylglycerol kinase HNO13_RS03425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HNO13_RS03435 ENOG4105CJ1 ABC, transporter HNO13_RS03470 ENOG4105CDY transcriptional regulatory protein HNO13_RS03480 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HNO13_RS03495 ENOG4105WEF catalase HNO13_RS03500 ENOG4105M18 -acetyltransferase HNO13_RS03510 ENOG4105H67 Protein of unknown function (DUF421) HNO13_RS03515 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HNO13_RS03520 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HNO13_RS03540 ENOG4106I4J membrane HNO13_RS03550 ENOG41082F9 transcriptional regulator HNO13_RS03555 ENOG41061H0 Monooxygenase HNO13_RS03560 ENOG4108R1P HNO13_RS03565 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HNO13_RS03570 ENOG4105E0M Sulfatase HNO13_RS03575 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HNO13_RS03585 ENOG41090R9 glycosyltransferase HNO13_RS03590 ENOG4107R51 Glycosyl transferase, family 2 HNO13_RS03595 ENOG41090R9 glycosyltransferase HNO13_RS03600 ENOG4105EU0 Major facilitator Superfamily HNO13_RS03605 ENOG4105CUB amino acid HNO13_RS03610 ENOG4105C26 Dehydrogenase HNO13_RS03615 ENOG4105FKZ Methyl-accepting chemotaxis HNO13_RS03620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HNO13_RS03625 ENOG4107TVC Glycosyl transferase, family 2 HNO13_RS03630 ENOG4105C5H ABC transporter HNO13_RS03635 ENOG4107SWG transcriptional regulator MERR family HNO13_RS03640 ENOG4105DXB Major Facilitator superfamily HNO13_RS03645 ENOG4105C5H ABC transporter HNO13_RS03650 ENOG4105FDU atp-dependent rna helicase HNO13_RS03660 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HNO13_RS03675 ENOG4108J20 pectate lyase HNO13_RS03680 ENOG4107QPK )-transporter HNO13_RS03700 ENOG4108VAC response regulator HNO13_RS03710 ENOG4108Z6X (sortase) family HNO13_RS03720 ENOG4108MRH transcriptional regulatory protein HNO13_RS03745 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) HNO13_RS03750 ENOG4108RPX mosc domain containing protein HNO13_RS03770 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HNO13_RS03810 ENOG4105C5Y PTS System HNO13_RS03815 ENOG4105CG3 alpha amylase, catalytic region HNO13_RS03820 ENOG4107414 GntR family transcriptional regulator HNO13_RS03825 ENOG4108RCM Nitroreductase HNO13_RS03840 ENOG4105CGH 5'-nucleotidase HNO13_RS03845 ENOG4107RKG DJ-1/PfpI family HNO13_RS03850 ENOG4105ETE Transcriptional regulator (LacI family HNO13_RS03860 ENOG4105FF2 Type I DHQase HNO13_RS03875 ENOG4105KJF protein tyrosine phosphatase HNO13_RS03885 ENOG4107U9T Pfam:Ribonuclease_BN HNO13_RS03890 ENOG4108ISG Major Facilitator HNO13_RS03895 ENOG4105UPD Calcium Proton HNO13_RS03905 ENOG4105D8X mechanosensitive ion channel HNO13_RS03925 ENOG4106KE4 Dehydrogenase HNO13_RS03935 ENOG4105D7N magnesium and cobalt transport protein CorA HNO13_RS03945 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HNO13_RS03965 ENOG4107RUY (E1 component), alpha subunit HNO13_RS03975 ENOG4107QKR Dehydrogenase HNO13_RS03985 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HNO13_RS03995 ENOG4105F8D glycoside hydrolase family 4 HNO13_RS04000 ENOG4108Q3X Transcriptional regulator HNO13_RS04005 ENOG4105CI1 PTS System HNO13_RS04010 ENOG4105BZ1 (ABC) transporter HNO13_RS04015 ENOG4105BZ1 (ABC) transporter HNO13_RS04025 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HNO13_RS04030 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HNO13_RS04035 ENOG4105U3E Transcriptional regulator HNO13_RS04040 ENOG4105DYS nad(p)h dehydrogenase (quinone) HNO13_RS04045 ENOG4105H93 Acyltransferase family HNO13_RS04060 ENOG4108YYS metal-dependent hydrolase (By similarity) HNO13_RS04065 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNO13_RS04070 ENOG410834F Transcriptional regulator HNO13_RS04080 ENOG4105JAB phenazine biosynthesis protein, phzf family HNO13_RS04085 ENOG4107Y03 Nitroreductase HNO13_RS04100 ENOG4105ECP epimerase HNO13_RS04105 ENOG410902V Modulates RecA activity (By similarity) HNO13_RS04115 ENOG4105F27 Major Facilitator HNO13_RS04125 ENOG4108TCS Glutamyl endopeptidase HNO13_RS04145 ENOG4106AKJ HNO13_RS04150 ENOG4105D74 hydrolase HNO13_RS04155 ENOG4105CKK Glycosyl transferase, family 2 HNO13_RS04160 ENOG4105EJV Membrane HNO13_RS04165 ENOG41067AE Membrane-bound metal-dependent hydrolase HNO13_RS04170 ENOG4105CEN a g-specific adenine glycosylase HNO13_RS04175 ENOG4106BXE HNO13_RS04180 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HNO13_RS04200 ENOG4105BZ1 (ABC) transporter HNO13_RS04205 ENOG4107NBY Membrane HNO13_RS04210 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HNO13_RS04215 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HNO13_RS04220 ENOG4105G5W regulator Fur family HNO13_RS04225 ENOG4105TUA UPF0295 protein HNO13_RS04335 ENOG4105EC3 peptidase S51, dipeptidase E HNO13_RS04340 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HNO13_RS04345 ENOG4105DNP FAD linked oxidase domain protein HNO13_RS04355 ENOG4105DEF Extracellular solute-binding protein, family 5 HNO13_RS04365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNO13_RS04370 ENOG4105C3U ABC transporter HNO13_RS04375 ENOG4108JQ7 (ABC) transporter HNO13_RS04390 ENOG4105E2Y ABC, transporter HNO13_RS04395 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HNO13_RS04400 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HNO13_RS04410 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HNO13_RS04415 ENOG4107D63 HNO13_RS04420 ENOG4105VZ8 Transcriptional regulator HNO13_RS04435 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HNO13_RS04445 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HNO13_RS04465 ENOG4105CYN Serine protein kinase HNO13_RS04475 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HNO13_RS04480 ENOG4105CW7 secretion protein, HlyD family HNO13_RS04485 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNO13_RS04490 ENOG4105CS1 NAD(P)H quinone oxidoreductase HNO13_RS04505 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HNO13_RS04510 ENOG4105CZV ABC transporter HNO13_RS04515 ENOG4105CJ1 ABC, transporter HNO13_RS04520 ENOG4108TU7 Inherit from COG: (ABC) transporter HNO13_RS04525 ENOG4105VEQ Cold shock protein HNO13_RS04535 ENOG4105BZU Histidine kinase HNO13_RS04575 ENOG4108YBP pseudouridine synthase HNO13_RS04585 ENOG41080XP Cbs domain HNO13_RS04590 ENOG4107YBY Hydrolase HNO13_RS04595 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HNO13_RS04600 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HNO13_RS04605 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HNO13_RS04615 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HNO13_RS04620 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HNO13_RS04630 ENOG4105BZU Histidine kinase HNO13_RS04635 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS04670 ENOG4105ED1 spovr family HNO13_RS04675 ENOG4105G6Z alkaline phosphatase HNO13_RS04690 ENOG4105BZN citrate synthase HNO13_RS04695 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HNO13_RS04700 ENOG4105CUB amino acid HNO13_RS04705 ENOG4105C8J )-transporter HNO13_RS04715 ENOG4105J37 HNO13_RS04720 ENOG4108AEY RNA polymerase sigma factor HNO13_RS04725 ENOG4105F6E Acyl-transferase HNO13_RS04730 ENOG4105C37 (CBS) domain HNO13_RS04740 ENOG4105CHM Aminotransferase HNO13_RS04745 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HNO13_RS04750 ENOG4105C37 (CBS) domain HNO13_RS04760 ENOG4105WMR Protein CrcB homolog HNO13_RS04765 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HNO13_RS04775 ENOG4105D64 Mechanosensitive ion channel HNO13_RS04780 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HNO13_RS04785 ENOG4107VMI polysaccharide deacetylase HNO13_RS04790 ENOG4105F0I Aminotransferase HNO13_RS04795 ENOG4105W1N transcriptional regulator HNO13_RS04800 ENOG4105IIP Membrane HNO13_RS04810 ENOG4105BZ1 (ABC) transporter HNO13_RS04815 ENOG4105BZ1 (ABC) transporter HNO13_RS04835 ENOG410839P HNO13_RS04845 ENOG4106MP8 UPF0754 membrane protein HNO13_RS04850 ENOG4105WZB UPF0342 protein HNO13_RS04855 ENOG4105F1N DNA alkylation repair HNO13_RS04865 ENOG4105D4P Coproporphyrinogen iii oxidase HNO13_RS04875 ENOG4107S91 Sodium hydrogen exchanger HNO13_RS04880 ENOG4105NCW Trka-c domain protein HNO13_RS04890 ENOG4105CGU Enoyl-CoA hydratase HNO13_RS04900 ENOG4108IUX (ABC) transporter HNO13_RS04905 ENOG4105RHA ABC transporter, permease HNO13_RS04910 ENOG4107VRP DNA repair exonuclease HNO13_RS04915 ENOG4106D4I domain protein HNO13_RS04920 ENOG4105EQI Metal Dependent Phosphohydrolase HNO13_RS04930 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HNO13_RS04975 ENOG4105NBU tryptophan transport protein HNO13_RS04980 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HNO13_RS04985 ENOG4105K59 histidine triad (HIT) protein HNO13_RS05015 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HNO13_RS05020 ENOG4105BZ4 penicillin-binding protein HNO13_RS05025 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HNO13_RS05030 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HNO13_RS05035 ENOG4105C1Q protoporphyrinogen oxidase HNO13_RS05045 ENOG4105ECB domain protein HNO13_RS05060 ENOG4105DER m42 family HNO13_RS05070 ENOG4106AXD HNO13_RS05075 ENOG4108RQ5 Beta-lactamase domain-containing protein HNO13_RS05080 ENOG4105DF9 Lipoate-protein, ligase HNO13_RS05090 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS05100 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HNO13_RS05110 ENOG4108HUF Transporter HNO13_RS05115 ENOG4107TB6 phosphoglycerate mutase HNO13_RS05125 ENOG4107F3J Amp-dependent synthetase and ligase HNO13_RS05130 ENOG4107ZYJ bioY protein HNO13_RS05135 ENOG4106YBV Methyl-accepting chemotaxis HNO13_RS05155 ENOG4105XVF Competence transcription factor HNO13_RS05165 ENOG4108ZMX Domain of unknown function (DU1801) HNO13_RS05175 ENOG4105X3H Excalibur domain protein HNO13_RS05180 ENOG4105K8R UPF0145 protein HNO13_RS05185 ENOG4105E1V na solute symporter HNO13_RS05190 ENOG4106CAD Protein of unknown function (DUF3311) HNO13_RS05195 ENOG41060YP HNO13_RS05210 ENOG4107SCK Monooxygenase HNO13_RS05215 ENOG4108INS Transcriptional regulator HNO13_RS05220 ENOG4108KK1 membrane protein AbrB duplication HNO13_RS05230 ENOG4108IG5 Transcriptional regulator HNO13_RS05240 ENOG4108QY0 Membrane HNO13_RS05245 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HNO13_RS05250 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HNO13_RS05260 ENOG4105EYH Exonuclease HNO13_RS05305 ENOG4105ERH Fumarylacetoacetate hydrolase HNO13_RS05325 ENOG4105CAQ asparagine synthetase HNO13_RS05335 ENOG4105UQX Mate efflux family protein HNO13_RS05340 ENOG4106HBX Transcriptional Regulator AraC Family HNO13_RS05345 ENOG4105ETE Transcriptional regulator (LacI family HNO13_RS05350 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HNO13_RS05355 ENOG4105SF0 DinB family HNO13_RS05360 ENOG4105MYW Pentapeptide repeat protein HNO13_RS05365 ENOG4105MA6 gCN5-related N-acetyltransferase HNO13_RS05375 ENOG4108VPT UPF0234 protein HNO13_RS05380 ENOG4105QNR S1 RNA binding domain protein HNO13_RS05385 ENOG4105DIH basic membrane HNO13_RS05390 ENOG4105C8Q Methyl-accepting chemotaxis HNO13_RS05400 ENOG4105EPR degv family HNO13_RS05405 ENOG4107AYK membrAne HNO13_RS05415 ENOG41073B9 HNO13_RS05425 ENOG4108KP7 hydrolase HNO13_RS05430 ENOG4108MXZ Esterase HNO13_RS05435 ENOG4105VG1 fes assembly suf system protein HNO13_RS05440 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HNO13_RS05445 ENOG4105IQ5 FAD linked oxidase domain protein HNO13_RS05455 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HNO13_RS05460 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HNO13_RS05465 ENOG4105CAS nag kinase HNO13_RS05470 ENOG4105C8Y Acetylornithine aminotransferase HNO13_RS05475 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HNO13_RS05485 ENOG4105DBV ornithine carbamoyltransferase HNO13_RS05510 ENOG4107RMD Basic membrane lipoprotein HNO13_RS05525 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HNO13_RS05530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HNO13_RS05540 ENOG4105C3U ABC transporter HNO13_RS05545 ENOG4108JQ7 (ABC) transporter HNO13_RS05560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNO13_RS05570 ENOG4105C31 Tryptophanyl-tRNA synthetase HNO13_RS05575 ENOG4108J59 Extracellular solute-binding protein, family 5 HNO13_RS05580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNO13_RS05585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNO13_RS05595 ENOG4108JQ7 (ABC) transporter HNO13_RS05610 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HNO13_RS05615 ENOG4108ZCF integral membrane protein HNO13_RS05620 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HNO13_RS05630 ENOG4105DPN Oligoendopeptidase f HNO13_RS05640 ENOG4105T58 Dithiol-disulfide isomerase HNO13_RS05645 ENOG4108Z18 K06886 hemoglobin HNO13_RS05650 ENOG4105E4C Lytic transglycosylase catalytic HNO13_RS05655 ENOG4105MIX Adenylate cyclase HNO13_RS05670 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HNO13_RS05675 ENOG4105EMS pseudouridine synthase HNO13_RS05680 ENOG4107S1Q Phosphatase HNO13_RS05690 ENOG4105ETU transcriptional activator (TenA HNO13_RS05695 ENOG4108VEU Thiamine monophosphate synthase HNO13_RS05715 ENOG4105D06 uba thif-type nad fad binding protein HNO13_RS05720 ENOG4105DWF phosphomethylpyrimidine kinase HNO13_RS05725 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HNO13_RS05730 ENOG4107A88 HNO13_RS05780 ENOG4105ENA helicase HNO13_RS05800 ENOG4105CJ1 ABC, transporter HNO13_RS05815 ENOG4108ZMI UPF0477 protein HNO13_RS05825 ENOG4105C28 cystathionine HNO13_RS05830 ENOG4105C28 cystathionine HNO13_RS05850 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNO13_RS05895 ENOG4108NE4 HNO13_RS05970 ENOG4106BHF HNO13_RS05980 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase HNO13_RS06010 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HNO13_RS06015 ENOG4105CMR udp-glucose 4-epimerase HNO13_RS06020 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HNO13_RS06025 ENOG4105CK1 PTS System HNO13_RS06030 ENOG4105VCP PTS System HNO13_RS06040 ENOG4105E98 transcriptional regulator DeoR family HNO13_RS06055 ENOG4105KT7 mgtC SapB transporter HNO13_RS06080 ENOG4108IEG Formate dehydrogenase Alpha subunit HNO13_RS06090 ENOG4106A3M Cytochrome p-450 HNO13_RS06095 ENOG41087PP glycosyltransferase MGT family HNO13_RS06105 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HNO13_RS06110 ENOG4105C4B ABC transporter, permease HNO13_RS06115 ENOG4108IXI (ABC) transporter HNO13_RS06125 ENOG4105Q95 Cupin 2, conserved barrel domain protein HNO13_RS06140 ENOG4105D2H Uronic isomerase HNO13_RS06145 ENOG4105CT4 transporter HNO13_RS06150 ENOG4107KJX Transcriptional regulator HNO13_RS06155 ENOG4107QZW Altronate oxidoreductase HNO13_RS06160 ENOG4105CTX dehydratase HNO13_RS06165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS06170 ENOG4105F3H Histidine kinase HNO13_RS06190 ENOG4105BZU Histidine kinase HNO13_RS06195 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS06210 ENOG4108JJA ABC, transporter HNO13_RS06230 ENOG4107TSN permease HNO13_RS06250 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HNO13_RS06255 ENOG4105KWG Pfam:DUF1696 HNO13_RS06260 ENOG4105K7W phage-related replication protein HNO13_RS06270 ENOG410635T phage-like element pbsx protein HNO13_RS06315 ENOG4108TFU terminase (Small subunit) HNO13_RS06320 ENOG4105IG6 Phage terminase, large subunit HNO13_RS06325 ENOG4108MDF Phage Portal Protein HNO13_RS06350 ENOG41060SN HNO13_RS06365 ENOG4105PQS phage protein HNO13_RS06370 ENOG4105FR7 XkdM protein, phage-like element PBSX HNO13_RS06375 ENOG4105MTC XkdN-like protein HNO13_RS06385 ENOG4108FKH Transglycosylase SLT domain HNO13_RS06385 ENOG4108FKH Transglycosylase SLT domain HNO13_RS06385 ENOG4108FKH Transglycosylase SLT domain HNO13_RS06390 ENOG4108WZM domain protein HNO13_RS06395 ENOG4105X7F HNO13_RS06405 ENOG4105MFU Protein of unknown function (DUF2634) HNO13_RS06410 ENOG41066EA baseplate J family protein HNO13_RS06415 ENOG410906S phage-like element pbsx protein xkdt HNO13_RS06425 ENOG41068G1 HNO13_RS06455 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HNO13_RS06470 ENOG4105CJ3 phosphate transporter HNO13_RS06475 ENOG4107GRR phosphate transport regulator HNO13_RS06480 ENOG4107R7I amino acid HNO13_RS06490 ENOG4105EDW glycosyl transferase, family 39 HNO13_RS06495 ENOG4105CKK Glycosyl transferase, family 2 HNO13_RS06500 ENOG4105C0H protease HNO13_RS06510 ENOG4108ME1 Peptidase M55 D-aminopeptidase HNO13_RS06515 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HNO13_RS06520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HNO13_RS06525 ENOG4105C3U ABC transporter HNO13_RS06535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HNO13_RS06540 ENOG4105DTQ mandelate racemase muconate lactonizing HNO13_RS06545 ENOG4107SN7 NLP P60 protein HNO13_RS06550 ENOG4108JQ7 (ABC) transporter HNO13_RS06555 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HNO13_RS06560 ENOG4107TUM Amidinotransferase HNO13_RS06565 ENOG4108S4H thioesterase Superfamily protein HNO13_RS06570 ENOG4108428 Inherit from COG: -acetyltransferase HNO13_RS06580 ENOG41080TC multidrug resistance protein HNO13_RS06585 ENOG4105CIY formyltetrahydrofolate deformylase HNO13_RS06590 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HNO13_RS06605 ENOG4105K56 Transcriptional regulator HNO13_RS06610 ENOG4108ZHJ Organic hydroperoxide resistance protein HNO13_RS06625 ENOG4107TVC Glycosyl transferase, family 2 HNO13_RS06635 ENOG4105D8G Major Facilitator superfamily HNO13_RS06640 ENOG4108Y4K DNA-binding transcriptional activator HNO13_RS06645 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HNO13_RS06650 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HNO13_RS06660 ENOG4108W7F transporter, permease HNO13_RS06665 ENOG4108JJB ABC transporter HNO13_RS06670 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HNO13_RS06675 ENOG4105VRS hydrolase family 18 HNO13_RS06685 ENOG4105CJW magnesium transporter HNO13_RS06690 ENOG4105V75 Transcriptional regulator HNO13_RS06715 ENOG4105DQE DNA ligase HNO13_RS06720 ENOG4105FDF Could be involved in DNA repair (By similarity) HNO13_RS06725 ENOG4107T5V SNARE associated Golgi HNO13_RS06730 ENOG4107TS3 membrane protein, TerC HNO13_RS06735 ENOG4108WZW RNA polymerase sigma HNO13_RS06745 ENOG410681C small acid-soluble spore protein HNO13_RS06755 ENOG4105D0M Protease HtpX homolog HNO13_RS06765 ENOG410900G Protein of unknown function (DUF421) HNO13_RS06775 ENOG4108TGC Acyltransferase HNO13_RS06780 ENOG4105BZU Histidine kinase HNO13_RS06785 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HNO13_RS06790 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HNO13_RS06800 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HNO13_RS06810 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HNO13_RS06815 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HNO13_RS06820 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HNO13_RS06825 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HNO13_RS06835 ENOG4105BZU Histidine kinase HNO13_RS06840 ENOG41090MY MarR family Transcriptional regulator HNO13_RS06845 ENOG4105ER2 Ompa motb domain protein HNO13_RS06850 ENOG4105E14 MotA TolQ exbB proton channel HNO13_RS06860 ENOG4108K88 Membrane HNO13_RS06870 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HNO13_RS06875 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HNO13_RS06880 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HNO13_RS06885 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HNO13_RS06905 ENOG4105F0V Cell wall hydrolase HNO13_RS06920 ENOG4105C59 p-type ATPase HNO13_RS06925 ENOG4105DC7 peptidase M24 HNO13_RS06935 ENOG4105CID antiterminator HNO13_RS06945 ENOG4105KRI phosphocarrier protein (HPr HNO13_RS06950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HNO13_RS06960 ENOG4105F6S Spore photoproduct lyase HNO13_RS06965 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HNO13_RS06970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HNO13_RS06975 ENOG4105K4I Scp-like extracellular HNO13_RS06985 ENOG4105BZU Histidine kinase HNO13_RS06990 ENOG4105CHM Aminotransferase HNO13_RS07000 ENOG4107R88 Chemotaxis protein (CheV) HNO13_RS07005 ENOG4105UIN HNO13_RS07015 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HNO13_RS07025 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HNO13_RS07040 ENOG4105EPM Diguanylate phosphodiesterase HNO13_RS07045 ENOG4107IN1 Protein of unknown function (DUF1797) HNO13_RS07050 ENOG4108XRC Protein of unknown function (DUF458) HNO13_RS07080 ENOG4105NQC Flavodoxin HNO13_RS07100 ENOG4105D8X mechanosensitive ion channel HNO13_RS07105 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HNO13_RS07120 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HNO13_RS07125 ENOG4105D06 uba thif-type nad fad binding protein HNO13_RS07130 ENOG4105CVM Molybdenum cofactor synthesis domain protein HNO13_RS07135 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HNO13_RS07140 ENOG4108ZAF Molybdopterin HNO13_RS07145 ENOG41067WU Molybdopterin converting factor (Subunit 1) HNO13_RS07155 ENOG4107X8C Efflux transporter RND family MFP subunit HNO13_RS07160 ENOG4105C19 ABC transporter HNO13_RS07165 ENOG4107RBB ABC transporter, permease HNO13_RS07170 ENOG4105E98 transcriptional regulator DeoR family HNO13_RS07175 ENOG4105DE4 1-phosphofructokinase HNO13_RS07180 ENOG4105DM4 PTS System HNO13_RS07195 ENOG4105C5H ABC transporter HNO13_RS07200 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HNO13_RS07225 ENOG4105BZU Histidine kinase HNO13_RS07235 ENOG4107ZYR domain protein HNO13_RS07240 ENOG4105CPN adenine deaminase HNO13_RS07245 ENOG4105CN5 Metallo-Beta-Lactamase HNO13_RS07250 ENOG4106148 UPF0356 protein HNO13_RS07255 ENOG4108X4Q Hydrolase HNO13_RS07260 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HNO13_RS07275 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HNO13_RS07280 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS07285 ENOG4107SQU synthase HNO13_RS07290 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS07295 ENOG4107SQU synthase HNO13_RS07300 ENOG4107SQU synthase HNO13_RS07305 ENOG4107SQU synthase HNO13_RS07310 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS07315 ENOG4105FQP Beta-lactamase HNO13_RS07325 ENOG4105CPP Dehydrogenase, E1 component HNO13_RS07330 ENOG4105C7S Dehydrogenase HNO13_RS07335 ENOG4107QN2 dihydrolipoyl dehydrogenase HNO13_RS07355 ENOG4105CXN decarboxylase HNO13_RS07360 ENOG4105WBI UPF0223 protein HNO13_RS07375 ENOG4105ECY inositol monophosphatase HNO13_RS07385 ENOG4105D4Y metalloprotease HNO13_RS07420 ENOG4105CI3 gtp-binding protein typa HNO13_RS07425 ENOG4105QA2 HNO13_RS07440 ENOG4108IAB Phoh family HNO13_RS07450 ENOG4105CSV Glutaminase HNO13_RS07460 ENOG4105CNI cell division protein FtsW HNO13_RS07465 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HNO13_RS07475 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HNO13_RS07485 ENOG4105BZ9 Cytochrome C oxidase, subunit I HNO13_RS07490 ENOG4105CCU oxidase (Subunit III) HNO13_RS07495 ENOG41064X9 cytochrome C oxidase subunit IV HNO13_RS07510 ENOG41080XQ Signal transduction protein with cbs domains HNO13_RS07515 ENOG4106UY4 Inherit from COG: Scp-like extracellular HNO13_RS07545 ENOG4106H78 methyltransferase HNO13_RS07550 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HNO13_RS07555 ENOG4105H20 Sporulation integral membrane protein YlbJ HNO13_RS07560 ENOG4105D78 K07001 NTE family protein HNO13_RS07565 ENOG41063PX domain protein HNO13_RS07570 ENOG4105CDE UPF0348 protein HNO13_RS07575 ENOG4105KNH Nucleic acid-binding protein HNO13_RS07605 ENOG4108V6E Cell division protein mraZ HNO13_RS07610 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HNO13_RS07620 ENOG4105CJN penicillin-binding protein HNO13_RS07625 ENOG4105CJN penicillin-binding protein HNO13_RS07630 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HNO13_RS07635 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HNO13_RS07640 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HNO13_RS07645 ENOG4105CNI cell division protein FtsW HNO13_RS07650 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HNO13_RS07655 ENOG4105D4A Cell wall formation (By similarity) HNO13_RS07660 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HNO13_RS07665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HNO13_RS07670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HNO13_RS07680 ENOG4105FFI sigma-e processing peptidase spoiiga HNO13_RS07685 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS07695 ENOG4105DKW ABC transporter HNO13_RS07705 ENOG4105WR5 sporulation protein, YlmC YmxH family HNO13_RS07710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HNO13_RS07715 ENOG4105DFA alanine racemase domain protein HNO13_RS07720 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HNO13_RS07725 ENOG41067XK integral membrane protein HNO13_RS07730 ENOG4105DBK s4 domain protein HNO13_RS07740 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HNO13_RS07750 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HNO13_RS07755 ENOG4105C34 Pseudouridine synthase HNO13_RS07760 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HNO13_RS07770 ENOG4105CXT aspartate transcarbamylase HNO13_RS07780 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HNO13_RS07785 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HNO13_RS07790 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HNO13_RS07795 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HNO13_RS07800 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HNO13_RS07805 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HNO13_RS07820 ENOG4107RIQ Sulfate adenylate transferase HNO13_RS07830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HNO13_RS07835 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HNO13_RS07840 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HNO13_RS07855 ENOG4105DSJ YicC domain protein HNO13_RS07860 ENOG4105KC4 UPF0296 protein HNO13_RS07865 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HNO13_RS07875 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HNO13_RS07880 ENOG4105C25 Primosomal protein n' HNO13_RS07885 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HNO13_RS07890 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HNO13_RS07895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HNO13_RS07900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HNO13_RS07905 ENOG4108ZF3 Phosphatase HNO13_RS07910 ENOG4105D9P serine threonine protein kinase HNO13_RS07915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HNO13_RS07920 ENOG4105DJV ribulose-phosphate 3-epimerase HNO13_RS07925 ENOG4105FJ0 thiamine HNO13_RS07935 ENOG4105VB9 50S ribosomal protein l28 HNO13_RS07940 ENOG4108ZAA Alkaline-shock protein HNO13_RS07945 ENOG4105DP4 dak2 domain fusion protein ylov HNO13_RS07955 ENOG4105EJQ L-serine dehydratase HNO13_RS07960 ENOG4105CB5 ATP-dependent DNA helicase recG HNO13_RS07965 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HNO13_RS07970 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HNO13_RS07975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HNO13_RS07980 ENOG4105CHR reductase HNO13_RS07990 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HNO13_RS07995 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HNO13_RS08000 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HNO13_RS08010 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HNO13_RS08020 ENOG4105K5M 30s ribosomal protein S16 HNO13_RS08025 ENOG4108BW8 UPF0109 protein HNO13_RS08040 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HNO13_RS08045 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HNO13_RS08050 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HNO13_RS08055 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HNO13_RS08065 ENOG4105VM1 flagellar HNO13_RS08070 ENOG4105CMV Succinyl-CoA synthetase subunit beta HNO13_RS08075 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HNO13_RS08080 ENOG4105C79 DNA protecting protein DprA HNO13_RS08085 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HNO13_RS08090 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HNO13_RS08095 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNO13_RS08100 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HNO13_RS08105 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HNO13_RS08115 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HNO13_RS08120 ENOG4108ZC9 flagellar basal-body rod protein flgc HNO13_RS08125 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HNO13_RS08130 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HNO13_RS08135 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HNO13_RS08150 ENOG4106YF4 Flagellar biosynthesis chaperone HNO13_RS08160 ENOG410696Y Flagellar hook-length control protein HNO13_RS08165 ENOG410822I Flagellar hook capping protein HNO13_RS08170 ENOG4108JQA flagellar HNO13_RS08175 ENOG41068WV flagellar FlbD family protein HNO13_RS08185 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HNO13_RS08190 ENOG4105DD5 Flagellar motor switch protein HNO13_RS08195 ENOG4107YTP response regulator receiver protein HNO13_RS08205 ENOG4105CN7 Flagellar biosynthetic protein FliP HNO13_RS08210 ENOG4105VS8 Flagellar biosynthetic protein fliq HNO13_RS08215 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HNO13_RS08220 ENOG4105D00 flagellar biosynthetic protein flhB HNO13_RS08225 ENOG4105D7B Flagellar biosynthesis protein flha HNO13_RS08230 ENOG4105FZW flagellar biosynthesis regulator FlhF HNO13_RS08240 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HNO13_RS08245 ENOG4105CBS Chea signal transduction histidine kinase HNO13_RS08250 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HNO13_RS08260 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HNO13_RS08265 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS08275 ENOG4105CE9 30S ribosomal protein S2 HNO13_RS08285 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HNO13_RS08290 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HNO13_RS08295 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HNO13_RS08300 ENOG4105KNE Phosphatidate cytidylyltransferase HNO13_RS08310 ENOG4105DZP Membrane-associated zinc metalloprotease HNO13_RS08315 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HNO13_RS08320 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HNO13_RS08325 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HNO13_RS08330 ENOG4105CHV Transcription elongation factor NusA HNO13_RS08335 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HNO13_RS08340 ENOG4105VHM ribosomal protein HNO13_RS08345 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HNO13_RS08350 ENOG4105W7A Protein of unknown function (DUF503) HNO13_RS08355 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HNO13_RS08360 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HNO13_RS08365 ENOG4105DTN riboflavin biosynthesis protein ribF HNO13_RS08370 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HNO13_RS08375 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HNO13_RS08385 ENOG4105C1V Peptidase, M16 HNO13_RS08395 ENOG4105E35 Dipicolinate synthase subunit A HNO13_RS08400 ENOG4108S0H Dipicolinic acid synthetase, b subunit HNO13_RS08405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HNO13_RS08415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HNO13_RS08425 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HNO13_RS08435 ENOG4105CNU cell division protein FtsK HNO13_RS08440 ENOG4105FDP GntR family transcriptional regulator HNO13_RS08455 ENOG4105EYF MMPL domain protein HNO13_RS08470 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HNO13_RS08475 ENOG4105XZV Protein of unknown function (DUF3243) HNO13_RS08490 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HNO13_RS08495 ENOG4105CEV competence damage-inducible protein HNO13_RS08500 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HNO13_RS08505 ENOG4108A04 Beta-lactamase HNO13_RS08515 ENOG4105D48 metallophosphoesterase HNO13_RS08520 ENOG4105MCT stage V sporulation protein S HNO13_RS08525 ENOG4105CPQ Dehydrogenase HNO13_RS08530 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HNO13_RS08535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HNO13_RS08555 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HNO13_RS08580 ENOG4108151 Beta-lactamase domain protein HNO13_RS08585 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HNO13_RS08590 ENOG4108JA1 polyketide synthase HNO13_RS08595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HNO13_RS08600 ENOG41062T2 Acyl carrier protein HNO13_RS08605 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HNO13_RS08610 ENOG4108MGH Enoyl-CoA hydratase HNO13_RS08615 ENOG4108KQ6 Enoyl-CoA hydratase HNO13_RS08620 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS08625 ENOG4107SQU synthase HNO13_RS08635 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS08645 ENOG4106A3M Cytochrome p-450 HNO13_RS08650 ENOG4105WFK nuclease HNO13_RS08655 ENOG4105XPP Protein of unknown function (DUF1275) HNO13_RS08665 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HNO13_RS08675 ENOG4105K7W phage-related replication protein HNO13_RS08680 ENOG4108X3M OsmC Ohr family protein HNO13_RS08705 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HNO13_RS08730 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HNO13_RS08735 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HNO13_RS08745 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNO13_RS08750 ENOG4106F1P AAA ATPase, central domain protein HNO13_RS08755 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HNO13_RS08760 ENOG4105CXI aluminum resistance protein HNO13_RS08765 ENOG4105KV4 Transcriptional regulator HNO13_RS08770 ENOG4105C5F glutamine synthetase HNO13_RS08780 ENOG4105CT4 transporter HNO13_RS08785 ENOG4105DSG hydrolase family 43 HNO13_RS08795 ENOG4105C93 Xylose Isomerase HNO13_RS08800 ENOG4105CMG Carbohydrate kinase HNO13_RS08805 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HNO13_RS08825 ENOG4105DQ4 alcohol dehydrogenase HNO13_RS08865 ENOG4108M1A Chitin-binding protein HNO13_RS08890 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HNO13_RS08895 ENOG4105K7W phage-related replication protein HNO13_RS08920 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HNO13_RS08930 ENOG4108SVB resolvase HNO13_RS08935 ENOG4105VPS UPF0291 protein HNO13_RS08940 ENOG4105CV1 Transketolase (EC 2.2.1.1) HNO13_RS08950 ENOG4105VXM UPF0154 protein HNO13_RS08960 ENOG4107QIV Cytochrome c biogenesis protein HNO13_RS08995 ENOG4108I0Z Aconitate hydratase HNO13_RS09000 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HNO13_RS09015 ENOG41067CD Small, acid-soluble spore protein Tlp HNO13_RS09025 ENOG4105MI2 HNO13_RS09030 ENOG4105W8X HesB YadR YfhF-family protein HNO13_RS09035 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HNO13_RS09040 ENOG4105K4P CoA-binding domain protein HNO13_RS09045 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HNO13_RS09070 ENOG4105CPQ Dehydrogenase HNO13_RS09075 ENOG4108UHU Aldolase HNO13_RS09080 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HNO13_RS09085 ENOG4105DMW Dehydrogenase reductase HNO13_RS09110 ENOG4105FVX HNO13_RS09135 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HNO13_RS09145 ENOG4107SYN Glycosyl hydrolases family 43 HNO13_RS09170 ENOG4105DTD Dehydrogenase HNO13_RS09175 ENOG4108IIH CoA-transferase subunit B HNO13_RS09180 ENOG4105D6N CoA-transferase, subunit a HNO13_RS09185 ENOG4105CY2 Citrate transporter HNO13_RS09190 ENOG4106A3M Cytochrome p-450 HNO13_RS09195 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HNO13_RS09200 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HNO13_RS09205 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HNO13_RS09210 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HNO13_RS09215 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HNO13_RS09225 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HNO13_RS09230 ENOG4107T5V SNARE associated Golgi HNO13_RS09235 ENOG4107QX3 carboxylase HNO13_RS09240 ENOG4105E39 Enoyl-CoA hydratase HNO13_RS09245 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HNO13_RS09250 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HNO13_RS09255 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HNO13_RS09260 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS09265 ENOG4105C1G acyl-Coa dehydrogenase HNO13_RS09270 ENOG4105F32 YngK protein HNO13_RS09275 ENOG4106U2H Protein of unknown function (DUF1360) HNO13_RS09285 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS09290 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS09300 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS09305 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HNO13_RS09310 ENOG4108N2V aldose 1-epimerase HNO13_RS09315 ENOG4107QJQ Mate efflux family protein HNO13_RS09340 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HNO13_RS09345 ENOG4108RWP Major Facilitator Superfamily protein HNO13_RS09350 ENOG4105WAB arsR family transcriptional regulator HNO13_RS09355 ENOG4105C22 threonyL-tRNA synthetase HNO13_RS09360 ENOG4108KSA LysR family transcriptional regulator HNO13_RS09365 ENOG4105CB2 alcohol dehydrogenase HNO13_RS09370 ENOG4105BZ8 glutamate synthase HNO13_RS09375 ENOG4105CBC glutamate synthase HNO13_RS09380 ENOG4105C5Q Transcriptional regulator HNO13_RS09385 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HNO13_RS09410 ENOG4108UB7 HNO13_RS09415 ENOG4105IE8 Alpha-ketoglutarate permease HNO13_RS09420 ENOG4107U6E carbohydrate kinase FGGY HNO13_RS09425 ENOG4108M3J Dehydrogenase HNO13_RS09430 ENOG4108J2R molybdopterin oxidoreductase HNO13_RS09445 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HNO13_RS09455 ENOG4108Z7R Chaperone CsaA HNO13_RS09460 ENOG4105FTV AraC Family Transcriptional Regulator HNO13_RS09470 ENOG4108W8B Beta-lactamase domain protein HNO13_RS09480 ENOG4105KTU Transcriptional regulator, arsr family HNO13_RS09490 ENOG4108SJC Membrane HNO13_RS09515 ENOG41069ER domain protein HNO13_RS09520 ENOG4105C9U ATP-dependent DNA helicase RecQ HNO13_RS09530 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HNO13_RS09535 ENOG4105SCY DNAK suppressor HNO13_RS09580 ENOG4105C26 Dehydrogenase HNO13_RS09585 ENOG4105EWU Squalene--hopene cyclase HNO13_RS09590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HNO13_RS09595 ENOG4105C8J )-transporter HNO13_RS09600 ENOG4105C09 Bile acid HNO13_RS09610 ENOG4105C7S Dehydrogenase HNO13_RS09615 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HNO13_RS09620 ENOG4107T89 von Willebrand factor, type A HNO13_RS09625 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HNO13_RS09635 ENOG4105K4H Nlp p60 protein HNO13_RS09640 ENOG41087PP glycosyltransferase MGT family HNO13_RS09650 ENOG4107QMU Mate efflux family protein HNO13_RS09655 ENOG4106SCS STAS domain HNO13_RS09675 ENOG4105FR1 rard protein HNO13_RS09690 ENOG41090U3 tautomerase HNO13_RS09710 ENOG4105FBA Phospholipase Carboxylesterase HNO13_RS09725 ENOG4105E1V na solute symporter HNO13_RS09735 ENOG4105CS2 ec 3.2.1.21 HNO13_RS09740 ENOG4108S3Y transcriptional regulator HNO13_RS09760 ENOG4108VXD carboxy-peptidase HNO13_RS09765 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HNO13_RS09775 ENOG4106Z5R HNO13_RS09780 ENOG410841Q phosphoesterase PA-phosphatase related protein HNO13_RS09815 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HNO13_RS09820 ENOG4108TSC N-acetyltransferase HNO13_RS09825 ENOG4107S4Y M20 DapE family protein YgeY HNO13_RS09840 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HNO13_RS09845 ENOG4105FTQ Dna gyrase HNO13_RS09980 ENOG4106ANW SMI1_KNR4 HNO13_RS09985 ENOG4106BHF HNO13_RS10010 ENOG4105E0X reductase HNO13_RS10015 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HNO13_RS10025 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HNO13_RS10030 ENOG41090WU lipolytic protein G-D-S-L family HNO13_RS10035 ENOG4108KF3 Electron transport protein SCO1 SenC HNO13_RS10045 ENOG4105C7B Threonine dehydratase HNO13_RS10055 ENOG4108UT2 hemolysin iii HNO13_RS10065 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HNO13_RS10070 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HNO13_RS10080 ENOG4107YX5 Pfam:DUF548 HNO13_RS10085 ENOG4108Y6J UPF0403 protein HNO13_RS10090 ENOG4105C01 Dihydroxy-acid dehydratase HNO13_RS10105 ENOG4108V06 Glutathione peroxidase HNO13_RS10110 ENOG4105CVG Homoserine O-transsuccinylase HNO13_RS10155 ENOG41081VK Ribonuclease HNO13_RS10180 ENOG410890F Dynamin family HNO13_RS10195 ENOG41065KQ synthase HNO13_RS10245 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HNO13_RS10250 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HNO13_RS10270 ENOG41068G1 HNO13_RS10280 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HNO13_RS10290 ENOG4108FKH Transglycosylase SLT domain HNO13_RS10435 ENOG4105QBX endodeoxyribonuclease RusA HNO13_RS10480 ENOG4108ZUE Phage regulatory protein rha HNO13_RS10495 ENOG41067QW Transcriptional regulator HNO13_RS10500 ENOG4105VTR Integrase HNO13_RS10505 ENOG4105C2W permease HNO13_RS10510 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HNO13_RS10515 ENOG4105CTD carboxy-peptidase HNO13_RS10520 ENOG4105DVT helicase HNO13_RS10535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HNO13_RS10545 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HNO13_RS10550 ENOG4108UKS UPF0398 protein HNO13_RS10565 ENOG4107X2U Inherit from COG: Exonuclease-like protein HNO13_RS10570 ENOG4108I5C dEAD DEAH box helicase HNO13_RS10615 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HNO13_RS10620 ENOG4105BZ4 penicillin-binding protein HNO13_RS10630 ENOG4105CSM endonuclease III HNO13_RS10640 ENOG4105C5S asparaginyl-tRNA synthetase HNO13_RS10645 ENOG4105CHM Aminotransferase HNO13_RS10655 ENOG4105YAC HNO13_RS10660 ENOG4105DVT helicase HNO13_RS10665 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HNO13_RS10675 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HNO13_RS10685 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HNO13_RS10690 ENOG4105CPK Glycosyl transferase (Group 1 HNO13_RS10695 ENOG4105FJR Lmbe family HNO13_RS10700 ENOG4108Z5K methylglyoxal synthase HNO13_RS10705 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HNO13_RS10710 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HNO13_RS10715 ENOG4108JYZ YitT family HNO13_RS10720 ENOG4105F0F Oxalate decarboxylase HNO13_RS10740 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HNO13_RS10760 ENOG41068YB TPR repeat-containing protein HNO13_RS10765 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HNO13_RS10775 ENOG4105CIH Imidazole acetol-phosphate transaminase HNO13_RS10785 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HNO13_RS10790 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HNO13_RS10795 ENOG4105DK0 Indole-3-glycerol phosphate synthase HNO13_RS10805 ENOG4105CRQ synthase (Component I) HNO13_RS10810 ENOG4105KHN chorismate mutase HNO13_RS10820 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HNO13_RS10825 ENOG4105BZU Histidine kinase HNO13_RS10830 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HNO13_RS10835 ENOG4105EAH synthase HNO13_RS10840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HNO13_RS10845 ENOG4105XXQ heptaprenyl diphosphate synthase component I HNO13_RS10850 ENOG4105WP2 Tryptophan RNA-binding attenuator protein HNO13_RS10855 ENOG4105EUJ GTP cyclohydrolase i HNO13_RS10860 ENOG4105K70 DNA-binding protein HNO13_RS10865 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HNO13_RS10880 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HNO13_RS10885 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HNO13_RS10905 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HNO13_RS10910 ENOG4105CAT Cytidine monophosphate kinase HNO13_RS10925 ENOG4105MSI germination protein ypeb HNO13_RS10935 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HNO13_RS10940 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HNO13_RS10955 ENOG4107RGJ metallophosphoesterase HNO13_RS10970 ENOG4105I7S Abortive infection protein HNO13_RS10975 ENOG4105C9U ATP-dependent DNA helicase RecQ HNO13_RS10980 ENOG4105T7X HNO13_RS10990 ENOG4108SAX Membrane HNO13_RS10995 ENOG4108JQ1 Dehydrogenase HNO13_RS11010 ENOG4105BZU Histidine kinase HNO13_RS11015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS11020 ENOG4105CRE cytochrome C HNO13_RS11025 ENOG4107TWT Cytochrome c biogenesis protein HNO13_RS11035 ENOG4105FE9 pseudouridine synthase HNO13_RS11045 ENOG4108JIC nucleoside recognition domain protein HNO13_RS11050 ENOG4105DZ1 carboxypeptidase HNO13_RS11060 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HNO13_RS11065 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HNO13_RS11085 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HNO13_RS11090 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HNO13_RS11095 ENOG4108R6K riboflavin synthase, subunit alpha HNO13_RS11120 ENOG4107ZE5 PPIases accelerate the folding of proteins HNO13_RS11125 ENOG4105PTM secreted protein HNO13_RS11130 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HNO13_RS11140 ENOG4105G6R Stage v sporulation protein ae HNO13_RS11150 ENOG4105CZ3 stage V sporulation protein ad HNO13_RS11155 ENOG41090VF Stage v sporulation protein ac HNO13_RS11170 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS11175 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HNO13_RS11180 ENOG41082AN stage II sporulation protein HNO13_RS11185 ENOG4105DZ1 carboxypeptidase HNO13_RS11205 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HNO13_RS11210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HNO13_RS11220 ENOG4105I3K Ferric uptake regulator, Fur family HNO13_RS11225 ENOG4105MZ9 stage II sporulation protein m HNO13_RS11245 ENOG4105DFD Na H antiporter HNO13_RS11250 ENOG4108IJ0 Aspartate ammonia-lyase HNO13_RS11255 ENOG4105HDK L-asparaginase HNO13_RS11260 ENOG4108IMY Transcriptional regulator HNO13_RS11270 ENOG4108YZ4 nudix hydrolase HNO13_RS11280 ENOG4105CPC Aldo Keto reductase HNO13_RS11300 ENOG4106HZJ HNO13_RS11305 ENOG4105RHY Pfam:UPF0157 HNO13_RS11310 ENOG4105KAC Antibiotic biosynthesis monooxygenase HNO13_RS11315 ENOG4108XET gCN5-related N-acetyltransferase HNO13_RS11320 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HNO13_RS11335 ENOG4105C02 permease HNO13_RS11345 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HNO13_RS11350 ENOG4105CS9 pantothenic acid kinase HNO13_RS11360 ENOG4108IXY short-chain dehydrogenase reductase HNO13_RS11365 ENOG41069FQ Metallo-beta-lactamase superfamily HNO13_RS11370 ENOG4105II7 pyrroline-5-carboxylate reductase HNO13_RS11375 ENOG4108KQ6 Enoyl-CoA hydratase HNO13_RS11380 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HNO13_RS11385 ENOG4106A3M Cytochrome p-450 HNO13_RS11400 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS11405 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS11415 ENOG4105C0W non-ribosomal peptide synthetase HNO13_RS11425 ENOG4105CHR reductase HNO13_RS11430 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS11445 ENOG4107QKG PfaD family HNO13_RS11450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HNO13_RS11455 ENOG4108K70 Transcriptional regulator HNO13_RS11465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HNO13_RS11475 ENOG410861F 50S ribosomal protein L33 HNO13_RS11480 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HNO13_RS11485 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HNO13_RS11490 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HNO13_RS11495 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HNO13_RS11505 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HNO13_RS11510 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HNO13_RS11515 ENOG4108HNZ carboxyl transferase HNO13_RS11520 ENOG4108ZVT methylmalonyl-coA epimerase HNO13_RS11530 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HNO13_RS11535 ENOG4108QEG Membrane HNO13_RS11540 ENOG4105CDA abc transporter atp-binding protein HNO13_RS11545 ENOG4105E5Q amino acid AbC transporter HNO13_RS11550 ENOG4108HW3 (ABC) transporter HNO13_RS11555 ENOG4108Y6J UPF0403 protein HNO13_RS11560 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HNO13_RS11565 ENOG4105C7S Dehydrogenase HNO13_RS11570 ENOG4105CPP Dehydrogenase, E1 component HNO13_RS11585 ENOG4105CKM Branched-chain carboxylic acid kinase HNO13_RS11590 ENOG4107RDP Dehydrogenase HNO13_RS11600 ENOG4108JUB Transcriptional regulator HNO13_RS11605 ENOG4106CCJ Protein of unknown function (DUF2627) HNO13_RS11610 ENOG4105CR4 methylisocitrate lyase HNO13_RS11615 ENOG4105DXD 2-methylcitrate dehydratase HNO13_RS11625 ENOG4105C1G acyl-Coa dehydrogenase HNO13_RS11630 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HNO13_RS11640 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HNO13_RS11645 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNO13_RS11670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HNO13_RS11685 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HNO13_RS11690 ENOG4107QQR Sporulation HNO13_RS11695 ENOG4105S1Z Stage IV sporulation protein B HNO13_RS11700 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HNO13_RS11705 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HNO13_RS11710 ENOG4105DX0 Hemolysin A HNO13_RS11715 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HNO13_RS11720 ENOG4105CTB Polyprenyl synthetase HNO13_RS11725 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HNO13_RS11730 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HNO13_RS11735 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HNO13_RS11740 ENOG4105M7K Involved in the transcription termination process (By similarity) HNO13_RS11745 ENOG4108ZSR alkaline shock protein HNO13_RS11750 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HNO13_RS11770 ENOG410644B Stage III sporulation protein af HNO13_RS11780 ENOG4105KQ4 Stage iii sporulation protein ad HNO13_RS11785 ENOG4108CQH stage III sporulation protein AC HNO13_RS11790 ENOG4105KR5 Stage iii sporulation protein HNO13_RS11795 ENOG4105CD2 stage iii sporulation protein aa HNO13_RS11805 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HNO13_RS11810 ENOG4105DC7 peptidase M24 HNO13_RS11820 ENOG4105CBJ Metal-dependent enzyme HNO13_RS11840 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HNO13_RS11845 ENOG4105WZW rhodanese family HNO13_RS11850 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HNO13_RS11860 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HNO13_RS11865 ENOG4105C0D helicase HNO13_RS11880 ENOG4108IMY Transcriptional regulator HNO13_RS11890 ENOG4105VFR signal peptidase HNO13_RS11950 ENOG4105C37 (CBS) domain HNO13_RS11975 ENOG4105C5X domain protein HNO13_RS12020 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HNO13_RS12035 ENOG41068DG YceG-like family HNO13_RS12040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HNO13_RS12045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HNO13_RS12050 ENOG4105E2Z phosphate ABC transporter (Permease HNO13_RS12055 ENOG4105C8U phosphate abc transporter HNO13_RS12060 ENOG4105CVA phosphate HNO13_RS12065 ENOG4107RF6 penicillin-binding protein HNO13_RS12075 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HNO13_RS12080 ENOG4105SXS Protein of unknown function (DUF456) HNO13_RS12095 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HNO13_RS12100 ENOG41063Y9 HNO13_RS12105 ENOG4108U5J '-nucleotidase HNO13_RS12110 ENOG4105N80 Ferric uptake regulator, Fur family HNO13_RS12115 ENOG4108JYZ YitT family HNO13_RS12120 ENOG41069ZM Protein of unknown function (DUF2624) HNO13_RS12125 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HNO13_RS12140 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HNO13_RS12145 ENOG4105EGD dinuclear metal center protein, YbgI family HNO13_RS12160 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS12165 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HNO13_RS12170 ENOG4108UPT UPF0178 protein HNO13_RS12175 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HNO13_RS12185 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HNO13_RS12190 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HNO13_RS12195 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HNO13_RS12205 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HNO13_RS12210 ENOG4105KG3 cytidine deaminase HNO13_RS12215 ENOG4107YR5 Diacylglycerol kinase HNO13_RS12220 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HNO13_RS12225 ENOG4105CTJ Metal Dependent Phosphohydrolase HNO13_RS12230 ENOG4105C9A Phoh family HNO13_RS12235 ENOG4105EI1 sporulation protein yqfd HNO13_RS12240 ENOG41068P3 sporulation protein YqfC HNO13_RS12250 ENOG4105DI5 UPF0365 protein HNO13_RS12255 ENOG4105F7J membrane-bound serine protease HNO13_RS12260 ENOG4105KTH gatB Yqey HNO13_RS12275 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HNO13_RS12280 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HNO13_RS12285 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HNO13_RS12290 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HNO13_RS12295 ENOG4105CFG Acts as a chaperone (By similarity) HNO13_RS12300 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HNO13_RS12305 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HNO13_RS12310 ENOG4105CSA Coproporphyrinogen iii oxidase HNO13_RS12315 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HNO13_RS12325 ENOG4108ZRV stage ii sporulation protein p HNO13_RS12330 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HNO13_RS12335 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HNO13_RS12340 ENOG4105TQK DNA polymerase iii, delta' subunit HNO13_RS12355 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HNO13_RS12360 ENOG4108UK2 deaminase HNO13_RS12365 ENOG4105KQC Competence protein HNO13_RS12375 ENOG4108D32 Methyltransferase HNO13_RS12385 ENOG4108WF2 Metal Dependent Phosphohydrolase HNO13_RS12390 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HNO13_RS12395 ENOG410812S Rna-binding protein HNO13_RS12400 ENOG4105E2X shikimate dehydrogenase HNO13_RS12405 ENOG4105CQW ribosome biogenesis GTPase YqeH HNO13_RS12410 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HNO13_RS12430 ENOG41080BT SNARE associated Golgi HNO13_RS12440 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS12455 ENOG41086D8 Transcriptional regulator HNO13_RS12460 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HNO13_RS12465 ENOG4108J8C transporter major facilitator family protein HNO13_RS12475 ENOG4108U7W acetyltransferase HNO13_RS12490 ENOG4108HCJ Hydrolase HNO13_RS12495 ENOG4108HCJ Hydrolase HNO13_RS12505 ENOG4105DG6 mannose-6-phosphate isomerase HNO13_RS12510 ENOG4105DM4 PTS System HNO13_RS12525 ENOG4108Z66 YbaK ebsC protein HNO13_RS12530 ENOG4107RSM transcriptional regulator HNO13_RS12535 ENOG4105D94 Major Facilitator Superfamily HNO13_RS12540 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HNO13_RS12545 ENOG41082JN Transcriptional regulator HNO13_RS12565 ENOG4105TMB Formate nitrite transporter HNO13_RS12570 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HNO13_RS12575 ENOG4108JB9 formate dehydrogenase HNO13_RS12590 ENOG4105C28 cystathionine HNO13_RS12620 ENOG4107XRG penicillin-binding protein HNO13_RS12625 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HNO13_RS12635 ENOG4105CFP Peptidase U32 HNO13_RS12640 ENOG4105XYU peptidase (U32 family) HNO13_RS12650 ENOG4105HHA aminodeoxychorismate lyase HNO13_RS12660 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HNO13_RS12665 ENOG4105VBH UPF0297 protein HNO13_RS12670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HNO13_RS12675 ENOG4105C02 permease HNO13_RS12680 ENOG4105CDA abc transporter atp-binding protein HNO13_RS12685 ENOG4105CT1 (ABC) transporter HNO13_RS12690 ENOG4105EAD ABC transporter HNO13_RS12695 ENOG4105DRP amino acid AbC transporter HNO13_RS12705 ENOG41060CR HNO13_RS12715 ENOG4105C7H Helicase, RecD TraA family HNO13_RS12725 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HNO13_RS12730 ENOG4105C3J Cysteine desulfurase HNO13_RS12740 ENOG4105D1H recombination factor protein RarA HNO13_RS12745 ENOG4105CUZ uba thif-type nad fad binding protein HNO13_RS12755 ENOG4105C9M aspartyl-trna synthetase HNO13_RS12760 ENOG4105CUT histidyl-tRNA synthetase HNO13_RS12770 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNO13_RS12775 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HNO13_RS12780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HNO13_RS12790 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HNO13_RS12795 ENOG41067VP Protein of unknown function (DUF1049) HNO13_RS12800 ENOG4105NCW Trka-c domain protein HNO13_RS12805 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HNO13_RS12815 ENOG4105CKP Polysaccharide Biosynthesis Protein HNO13_RS12820 ENOG4108QG2 Membrane HNO13_RS12825 ENOG4105NAP HNO13_RS12830 ENOG4105VIE preprotein translocase, subunit YajC HNO13_RS12835 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HNO13_RS12840 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HNO13_RS12845 ENOG41061AI Protein of unknown function (DUF2905) HNO13_RS12850 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HNO13_RS12855 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HNO13_RS12875 ENOG4106678 morphogenetic protein associated with SpoVID HNO13_RS12880 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HNO13_RS12885 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HNO13_RS12890 ENOG4108IYU L-aspartate oxidase HNO13_RS12905 ENOG4105CQC Prephenate dehydratase HNO13_RS12915 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HNO13_RS12925 ENOG4105K46 50S ribosomal protein l27 HNO13_RS12930 ENOG4105X36 (ribosomal) protein HNO13_RS12935 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HNO13_RS12950 ENOG4107QMS site-determining protein HNO13_RS12955 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HNO13_RS12960 ENOG4105YHC Rod shape-determining protein MreD HNO13_RS12970 ENOG4105DFF Rod shape-determining protein mreb HNO13_RS12975 ENOG4105W5Q DNA repair protein (RadC HNO13_RS12980 ENOG4108Z03 MAF-like protein HNO13_RS12990 ENOG4106A3R peptidase HNO13_RS12995 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HNO13_RS13000 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HNO13_RS13010 ENOG4106AR7 Spore coat protein HNO13_RS13015 ENOG41068KH stage VI sporulation protein D HNO13_RS13020 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HNO13_RS13025 ENOG4105D52 delta-aminolevulinic acid dehydratase HNO13_RS13035 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HNO13_RS13045 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HNO13_RS13055 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HNO13_RS13060 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HNO13_RS13065 ENOG4108IUQ atp-dependent protease HNO13_RS13070 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HNO13_RS13075 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HNO13_RS13085 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HNO13_RS13090 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HNO13_RS13095 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HNO13_RS13105 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HNO13_RS13110 ENOG4108ZP8 Acetolactate synthase small subunit HNO13_RS13115 ENOG4105C7K acetolactate synthase HNO13_RS13140 ENOG4105M59 Phosphodiesterase, mj0936 family HNO13_RS13145 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HNO13_RS13150 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HNO13_RS13155 ENOG4108XJQ germination protein HNO13_RS13160 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HNO13_RS13165 ENOG41067TZ transcriptional regulator, MarR family HNO13_RS13170 ENOG4105PFC Transcriptional regulator HNO13_RS13180 ENOG4105E33 succinate dehydrogenase HNO13_RS13190 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HNO13_RS13200 ENOG4105CFH Aspartokinase HNO13_RS13205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HNO13_RS13210 ENOG4105K63 Thioredoxin HNO13_RS13215 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HNO13_RS13220 ENOG4105C10 Electron transfer flavoprotein HNO13_RS13225 ENOG4105BZJ Electron transfer flavoprotein HNO13_RS13230 ENOG41060WC Enoyl-CoA hydratase HNO13_RS13235 ENOG4107Z3H Transcriptional regulator, TetR family HNO13_RS13240 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS13245 ENOG4108YV3 Protein of unknown function (DUF2711) HNO13_RS13255 ENOG4105C98 muts2 protein HNO13_RS13260 ENOG4105DCG PHP domain protein HNO13_RS13275 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HNO13_RS13280 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HNO13_RS13285 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HNO13_RS13290 ENOG4108RWN rrna methyltransferase HNO13_RS13295 ENOG41067MF small acid-soluble spore protein HNO13_RS13305 ENOG4105CQB FAD linked oxidase domain protein HNO13_RS13310 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HNO13_RS13320 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HNO13_RS13325 ENOG4105DRS transport system, permease HNO13_RS13340 ENOG4108MDK Dehydrogenase HNO13_RS13350 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HNO13_RS13355 ENOG4105EF1 ribulokinase HNO13_RS13365 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HNO13_RS13370 ENOG4105CN9 Peptidase m42 family protein HNO13_RS13380 ENOG410696E Membrane HNO13_RS13385 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HNO13_RS13390 ENOG4105VJV 50s ribosomal protein L35 HNO13_RS13395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HNO13_RS13400 ENOG41067MG lrgb family HNO13_RS13410 ENOG4105DY9 regulatoR HNO13_RS13415 ENOG4108HRK Histidine kinase HNO13_RS13425 ENOG4105C22 threonyL-tRNA synthetase HNO13_RS13430 ENOG4108TDW sporulation protein YtxC HNO13_RS13455 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HNO13_RS13460 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HNO13_RS13465 ENOG4105KVH Transcriptional regulator HNO13_RS13470 ENOG4105F27 Major Facilitator HNO13_RS13475 ENOG4105CV8 reductase HNO13_RS13480 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HNO13_RS13490 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HNO13_RS13495 ENOG4105C2M dna polymerase I HNO13_RS13500 ENOG4105BZU Histidine kinase HNO13_RS13505 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HNO13_RS13515 ENOG4108HMX isocitrate dehydrogenase (NADP) HNO13_RS13520 ENOG4105BZN citrate synthase HNO13_RS13525 ENOG4105G7B Protein of unknown function (DUF2992) HNO13_RS13540 ENOG4108REF Sporulation integral membrane protein ytvi HNO13_RS13545 ENOG4105FS0 cytoplasmic membrane protein HNO13_RS13550 ENOG4105CA9 Pyruvate kinase HNO13_RS13555 ENOG4105CTQ phosphohexokinase HNO13_RS13560 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HNO13_RS13565 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HNO13_RS13570 ENOG4105C6K Malic enzyme HNO13_RS13575 ENOG4105C0B DNA polymerase III (alpha subunit) HNO13_RS13580 ENOG4105VV2 HNO13_RS13590 ENOG4106EVM HNO13_RS13595 ENOG4105SFS phosphoesterase RecJ domain protein HNO13_RS13610 ENOG4105E8R UPF0173 metal-dependent hydrolase HNO13_RS13620 ENOG4105CH7 arginosuccinase HNO13_RS13625 ENOG4105CDH Citrulline--aspartate ligase HNO13_RS13630 ENOG4105EPU Molybdenum cofactor synthesis domain protein HNO13_RS13635 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HNO13_RS13645 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HNO13_RS13650 ENOG4105KBJ sporulation protein ytfj HNO13_RS13660 ENOG4105VK3 rdd domain containing protein HNO13_RS13665 ENOG4105D07 Signal peptide peptidase, SppA HNO13_RS13670 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HNO13_RS13675 ENOG4105EFZ amidohydrolase HNO13_RS13680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HNO13_RS13690 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HNO13_RS13715 ENOG4105U5Y Transcriptional regulator HNO13_RS13725 ENOG4105BZU Histidine kinase HNO13_RS13730 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HNO13_RS13735 ENOG4105C26 Dehydrogenase HNO13_RS13745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HNO13_RS13755 ENOG4108Z0Z intracellular protease Pfpi family HNO13_RS13775 ENOG4108NGU Transcriptional regulator HNO13_RS13790 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HNO13_RS13800 ENOG4105F1V Acetoin utilization protein HNO13_RS13805 ENOG4105W87 Cbs domain HNO13_RS13810 ENOG4105DGU Histone deacetylase HNO13_RS13815 ENOG4105ER2 Ompa motb domain protein HNO13_RS13820 ENOG4107R0U MotA TolQ exbB proton channel HNO13_RS13825 ENOG4105ETE Transcriptional regulator (LacI family HNO13_RS13830 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HNO13_RS13850 ENOG4105DFU Cell wall formation (By similarity) HNO13_RS13860 ENOG4108VDD TRNA binding domain protein HNO13_RS13875 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HNO13_RS13890 ENOG4105C6K Malic enzyme HNO13_RS13895 ENOG4105C8F Beta-lactamase domain protein HNO13_RS13900 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HNO13_RS13910 ENOG4108V15 phosphotransferase enzyme family HNO13_RS13925 ENOG4107F58 2'-5' rna ligase HNO13_RS13930 ENOG4105C6T cysteine synthase HNO13_RS13935 ENOG4107QSE Dipeptidase HNO13_RS13940 ENOG4105C7N Xanthine uracil vitamin C permease HNO13_RS13955 ENOG4105YW5 deoR family transcriptional regulator HNO13_RS13970 ENOG4105CBX hi0933 family HNO13_RS13975 ENOG4105C94 Transporter HNO13_RS14015 ENOG41085GJ domain protein HNO13_RS14020 ENOG4105C8T Leucyl-tRNA synthetase HNO13_RS14030 ENOG4105BZU Histidine kinase HNO13_RS14035 ENOG410605W Major Facilitator HNO13_RS14050 ENOG4105C19 ABC transporter HNO13_RS14055 ENOG4105EWM Histidine kinase HNO13_RS14065 ENOG4107R34 abc transporter permease protein HNO13_RS14070 ENOG4105C19 ABC transporter HNO13_RS14090 ENOG4105DVE abc transporter atp-binding protein HNO13_RS14095 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HNO13_RS14115 ENOG4105N5T Radical SAM Protein HNO13_RS14130 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HNO13_RS14140 ENOG4105E8V Alpha Beta Hydrolase Fold protein HNO13_RS14145 ENOG4108Z0R Transferase HNO13_RS14150 ENOG4105C85 amino acid HNO13_RS14155 ENOG4105CAQ asparagine synthetase HNO13_RS14160 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HNO13_RS14165 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HNO13_RS14180 ENOG4105D2X ABC transporter substrate-binding protein HNO13_RS14190 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HNO13_RS14205 ENOG4108RMU ferritin dps family protein HNO13_RS14220 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HNO13_RS14225 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HNO13_RS14230 ENOG4108V2W Carbonate dehydratase HNO13_RS14235 ENOG4105NRA 50s ribosomal protein l31 type b HNO13_RS14255 ENOG4105DTQ mandelate racemase muconate lactonizing HNO13_RS14260 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS14265 ENOG4108IPT Naphthoate synthase HNO13_RS14270 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HNO13_RS14275 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HNO13_RS14280 ENOG4105E4F Isochorismate synthase HNO13_RS14415 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HNO13_RS14420 ENOG4105DZ6 Band 7 protein HNO13_RS14430 ENOG4106DF1 HNO13_RS14435 ENOG4108VNY MOSC domain protein HNO13_RS14440 ENOG4108JB8 alcohol dehydrogenase HNO13_RS14450 ENOG4105TRT Transcriptional regulator HNO13_RS14465 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HNO13_RS14470 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HNO13_RS14490 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HNO13_RS14500 ENOG4105EE0 oxidoreductase HNO13_RS14505 ENOG4108Z0Z intracellular protease Pfpi family HNO13_RS14510 ENOG4105C8Q Methyl-accepting chemotaxis HNO13_RS14515 ENOG4105C8Q Methyl-accepting chemotaxis HNO13_RS14520 ENOG4105C8Q Methyl-accepting chemotaxis HNO13_RS14525 ENOG4105C8Q Methyl-accepting chemotaxis HNO13_RS14540 ENOG4105EA8 2-Nitropropane dioxygenase HNO13_RS14545 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HNO13_RS14555 ENOG4105C37 (CBS) domain HNO13_RS14570 ENOG4107PBV potassium channel HNO13_RS14575 ENOG4107PBV potassium channel HNO13_RS14590 ENOG4107QYV phosphohexose isomerase HNO13_RS14600 ENOG4105CHJ isochorismatase hydrolase HNO13_RS14610 ENOG4107QW4 alcohol dehydrogenase HNO13_RS14615 ENOG4105WG9 Conserved Protein HNO13_RS14625 ENOG4105CHM Aminotransferase HNO13_RS14630 ENOG4108ZB6 transcriptional regulator AsnC family HNO13_RS14635 ENOG4108MUZ hydrolase HNO13_RS14645 ENOG4105C87 Aminotransferase class I and II HNO13_RS14650 ENOG4108HGU Histidine kinase HNO13_RS14655 ENOG4105Y38 Kinase-associated protein B HNO13_RS14670 ENOG4105BZ4 penicillin-binding protein HNO13_RS14675 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HNO13_RS14690 ENOG4108MRH transcriptional regulatory protein HNO13_RS14695 ENOG4105DIH basic membrane HNO13_RS14700 ENOG4108JQ9 ABC transporter HNO13_RS14705 ENOG4105UIB (ABC) transporter HNO13_RS14720 ENOG4105D65 subunit l HNO13_RS14725 ENOG4105HC0 Na H antiporter HNO13_RS14730 ENOG4108ZE9 Monovalent cation H antiporter subunit C HNO13_RS14735 ENOG4108JPZ Monovalent cation H antiporter subunit D HNO13_RS14740 ENOG4105SC1 monovalent cation H antiporter subunit E HNO13_RS14750 ENOG4105KJM monovalent cation h antiporter subunit g HNO13_RS14755 ENOG4105KA0 thioesterase Superfamily protein HNO13_RS14765 ENOG4105BZU Histidine kinase HNO13_RS14790 ENOG4105D58 Diguanylate phosphodiesterase HNO13_RS14795 ENOG4105DAP Nicotinate phosphoribosyltransferase HNO13_RS14820 ENOG4105C02 permease HNO13_RS14835 ENOG410904N short-chain dehydrogenase reductase HNO13_RS14870 ENOG4108K8K Transcriptional regulator HNO13_RS14875 ENOG4105DCF alanine dehydrogenase HNO13_RS14885 ENOG4105WQT MbtH domain protein HNO13_RS14890 ENOG4105CEY Amp-dependent synthetase and ligase HNO13_RS14895 ENOG4105WQI isochorismatase HNO13_RS14900 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HNO13_RS14905 ENOG4105E4F Isochorismate synthase HNO13_RS14910 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HNO13_RS14915 ENOG4105NIV Esterase HNO13_RS14935 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HNO13_RS14945 ENOG41069ER domain protein HNO13_RS14960 ENOG4105CEP NADH dehydrogenase HNO13_RS14975 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HNO13_RS14990 ENOG4105CJ1 ABC, transporter HNO13_RS15015 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HNO13_RS15020 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HNO13_RS15025 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HNO13_RS15035 ENOG4105ZKE UPF0349 protein HNO13_RS15050 ENOG41083MR nifu domain-containing protein HNO13_RS15055 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HNO13_RS15060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HNO13_RS15065 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HNO13_RS15070 ENOG4105D6E homoserine dehydrogenase HNO13_RS15080 ENOG4108W5N phosphatidylglycerophosphatase a HNO13_RS15085 ENOG4105D4U had-superfamily hydrolase, subfamily iia HNO13_RS15095 ENOG4105MMD transcriptional regulator HNO13_RS15100 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HNO13_RS15105 ENOG4105FAA peptidase M23 HNO13_RS15110 ENOG4108YTE sporulation protein YunB HNO13_RS15115 ENOG4107R8B 5'-nucleotidase HNO13_RS15125 ENOG4105I3N Conserved Protein HNO13_RS15135 ENOG4105CD3 dihydroorotase HNO13_RS15140 ENOG4105G9B Transcriptional regulator HNO13_RS15165 ENOG4105C5R Aminotransferase HNO13_RS15175 ENOG4108K8S endonuclease I HNO13_RS15180 ENOG4108IJ9 (ABC) transporter HNO13_RS15185 ENOG4105FDP GntR family transcriptional regulator HNO13_RS15190 ENOG4108KPW sugar kinase HNO13_RS15195 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HNO13_RS15200 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HNO13_RS15205 ENOG4105XN3 extracellular solute-binding protein family 1 HNO13_RS15210 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HNO13_RS15215 ENOG4108Z6Z Transcriptional regulator HNO13_RS15230 ENOG4105PKS Excinuclease abc c subunit domain protein HNO13_RS15235 ENOG4107VFR oxidoreductase HNO13_RS15240 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HNO13_RS15250 ENOG41083Q9 chitosanase HNO13_RS15265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HNO13_RS15285 ENOG41068G1 HNO13_RS15305 ENOG4108FKH Transglycosylase SLT domain HNO13_RS15380 ENOG4105CNU cell division protein FtsK HNO13_RS15390 ENOG410682Q Phage transcriptional regulator, ArpU HNO13_RS15480 ENOG4105CFF transcriptional regulator HNO13_RS15500 ENOG4105DIW FeS assembly protein SUFB HNO13_RS15505 ENOG4108UNV SUF system FeS assembly protein, NifU family HNO13_RS15510 ENOG4105C9B Cysteine desulfurase HNO13_RS15515 ENOG4105JRK feS assembly protein SufD HNO13_RS15520 ENOG4105C3K feS assembly ATPase SufC HNO13_RS15535 ENOG4105D01 (LipO)protein HNO13_RS15540 ENOG4108UMI ABC transporter, permease HNO13_RS15545 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HNO13_RS15570 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HNO13_RS15575 ENOG41080E8 Transcriptional regulator, Spx MgsR family HNO13_RS15580 ENOG4105C1G acyl-Coa dehydrogenase HNO13_RS15585 ENOG4105CHU acetyl-coa acetyltransferase HNO13_RS15605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNO13_RS15620 ENOG41067TZ transcriptional regulator, MarR family HNO13_RS15625 ENOG4105C0R drug resistance transporter emrb qaca subfamily HNO13_RS15630 ENOG4105C5Q Transcriptional regulator HNO13_RS15650 ENOG4105E0A ABC, transporter HNO13_RS15665 ENOG4105E1F short-chain dehydrogenase reductase HNO13_RS15670 ENOG4105HUF DNA protection during starvation protein HNO13_RS15675 ENOG4105C0H protease HNO13_RS15685 ENOG4105F3H Histidine kinase HNO13_RS15695 ENOG41067SE Tetr family transcriptional regulator HNO13_RS15700 ENOG4105C9Q fumarate hydratase class II HNO13_RS15725 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS15730 ENOG4105ENE Histidine kinase HNO13_RS15745 ENOG41087YS Phage shock protein A HNO13_RS15760 ENOG4108WBT adenosyltransferase HNO13_RS15765 ENOG4105E0A ABC, transporter HNO13_RS15770 ENOG4105EHG Permease protein HNO13_RS15775 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HNO13_RS15780 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HNO13_RS15785 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HNO13_RS15795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HNO13_RS15805 ENOG4106DF4 Sigma-70, region 4 HNO13_RS15815 ENOG4105F0F Oxalate decarboxylase HNO13_RS15825 ENOG4105E0A ABC, transporter HNO13_RS15830 ENOG4105EHG Permease protein HNO13_RS15835 ENOG4105DQ5 transport system permease protein HNO13_RS15845 ENOG4105JQZ Methyltransferase HNO13_RS15850 ENOG4105D5Q Arginine ornithine antiporter HNO13_RS15860 ENOG4107K5X Membrane-bound metal-dependent hydrolase HNO13_RS15865 ENOG4107QZ2 Sulfatase HNO13_RS15870 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HNO13_RS15875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HNO13_RS15880 ENOG4105E0C molybdate abc transporter HNO13_RS15885 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS15890 ENOG4105BZU Histidine kinase HNO13_RS15895 ENOG4105CJ1 ABC, transporter HNO13_RS15905 ENOG4108KYE ABC-2 type transporter HNO13_RS15920 ENOG4105EEQ Na H antiporter HNO13_RS15925 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HNO13_RS15930 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HNO13_RS15935 ENOG4105EEM helicase HNO13_RS15940 ENOG4105EN6 Membrane HNO13_RS15955 ENOG4107ZQN disulfide bond HNO13_RS15960 ENOG4105C59 p-type ATPase HNO13_RS15965 ENOG4105C59 p-type ATPase HNO13_RS15970 ENOG410681U heavy metal transport detoxification protein HNO13_RS15975 ENOG4105VPX protein, conserved in bacteria HNO13_RS15980 ENOG4105D9R oxidoreductase HNO13_RS15985 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HNO13_RS16020 ENOG4105DEN Luciferase family HNO13_RS16025 ENOG4105CDA abc transporter atp-binding protein HNO13_RS16050 ENOG4108XSB acetyltransferase, (GNAT) family HNO13_RS16055 ENOG4108KSA LysR family transcriptional regulator HNO13_RS16060 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HNO13_RS16065 ENOG41067XF inhibitor HNO13_RS16100 ENOG41068G1 HNO13_RS16110 ENOG4107X35 defense response to bacterium HNO13_RS16180 ENOG4105CAR Terminase, large subunit HNO13_RS16215 ENOG410682Q Phage transcriptional regulator, ArpU HNO13_RS16350 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HNO13_RS16360 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HNO13_RS16365 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HNO13_RS16375 ENOG4105XZU Preprotein translocase, subunit SecG HNO13_RS16395 ENOG4105KVH Transcriptional regulator HNO13_RS16420 ENOG4105DA5 (ABC) transporter HNO13_RS16425 ENOG4105R40 Glycine betaine carnitine choline HNO13_RS16430 ENOG4108HQR Glycine betaine HNO13_RS16435 ENOG4105E90 ABC transporter HNO13_RS16440 ENOG4108IJ8 ABC transporter HNO13_RS16445 ENOG4107HG4 Transcriptional regulator HNO13_RS16450 ENOG4105R40 Glycine betaine carnitine choline HNO13_RS16455 ENOG4108HQR Glycine betaine HNO13_RS16460 ENOG4105E90 ABC transporter HNO13_RS16465 ENOG4108IJ8 ABC transporter HNO13_RS16470 ENOG4107HG4 Transcriptional regulator HNO13_RS16475 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HNO13_RS16485 ENOG4105T65 Membrane-associated protein HNO13_RS16490 ENOG4108W0I acetyltransferase HNO13_RS16505 ENOG4105FJR Lmbe family HNO13_RS16520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNO13_RS16525 ENOG4108IAJ Nad-dependent epimerase dehydratase HNO13_RS16530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNO13_RS16535 ENOG4107QQG Dehydrogenase HNO13_RS16540 ENOG4105IIU Aminopeptidase HNO13_RS16545 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HNO13_RS16550 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HNO13_RS16555 ENOG4105CP7 Triose-phosphate isomerase HNO13_RS16560 ENOG4105BZA Phosphoglycerate kinase HNO13_RS16565 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HNO13_RS16580 ENOG4105CMD Transcriptional regulator, GntR family HNO13_RS16585 ENOG4105DEN Luciferase family HNO13_RS16595 ENOG4105GZI Transcriptional regulator HNO13_RS16600 ENOG4107RT3 EamA-like transporter family HNO13_RS16610 ENOG4106KNT transcriptional regulator HNO13_RS16615 ENOG4105CMG Carbohydrate kinase HNO13_RS16620 ENOG4105C6Z Gluconate HNO13_RS16630 ENOG4107QR9 Iron-sulfur cluster binding protein HNO13_RS16635 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HNO13_RS16640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HNO13_RS16645 ENOG4105JXH GntR family transcriptional regulator HNO13_RS16650 ENOG4105DAA L-lactate HNO13_RS16655 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HNO13_RS16665 ENOG4108ZPC Polysaccharide pyruvyl transferase HNO13_RS16670 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNO13_RS16675 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HNO13_RS16680 ENOG4105D3Q Sugar transferase HNO13_RS16690 ENOG4105K64 Glycosyl transferase, family 2 HNO13_RS16700 ENOG4107QRS glycosyltransferase group 2 family protein HNO13_RS16705 ENOG41068W6 Capsular polysaccharide biosynthesis protein HNO13_RS16710 ENOG4108KMV Glycosyl transferase (Group 1 HNO13_RS16715 ENOG4105K64 Glycosyl transferase, family 2 HNO13_RS16720 ENOG4108PQP glycosyl transferase group 1 HNO13_RS16730 ENOG4108QV3 biosynthesis protein HNO13_RS16735 ENOG4105HTX biosynthesis protein HNO13_RS16745 ENOG4105EBR Carboxylesterase HNO13_RS16755 ENOG4105NAE bifunctional deaminase-reductase domain protein HNO13_RS16765 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HNO13_RS16770 ENOG4105PY6 Phenolic acid decarboxylase HNO13_RS16775 ENOG4105NI3 Protein of unknown function (DUF3237) HNO13_RS16820 ENOG4108HKT sucrose-6-phosphate hydrolase HNO13_RS16825 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HNO13_RS16830 ENOG4105ETE Transcriptional regulator (LacI family HNO13_RS16835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HNO13_RS16840 ENOG4108KAM Transcriptional regulator HNO13_RS16845 ENOG4105C7F AcnD-accessory protein PrpF HNO13_RS16855 ENOG4108URH decarboxylase HNO13_RS16860 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HNO13_RS16865 ENOG4105CHH sulfate transporter HNO13_RS16870 ENOG4108V2W Carbonate dehydratase HNO13_RS16875 ENOG4105C5I Dehydrogenase HNO13_RS16880 ENOG4105GGE ribonuclease HNO13_RS16885 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HNO13_RS16890 ENOG4105KRI phosphocarrier protein (HPr HNO13_RS16895 ENOG4105CIE May be required for sporulation (By similarity) HNO13_RS16900 ENOG4105CHW UPF0052 protein HNO13_RS16905 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HNO13_RS16910 ENOG4108Z4K mutator MutT protein HNO13_RS16915 ENOG4105C3M thioredoxin reductase HNO13_RS16930 ENOG4105BZU Histidine kinase HNO13_RS16935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS16940 ENOG4105GIG HNO13_RS16945 ENOG4105BZ1 (ABC) transporter HNO13_RS16950 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HNO13_RS16955 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HNO13_RS16960 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HNO13_RS16965 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HNO13_RS16970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HNO13_RS16975 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HNO13_RS16980 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HNO13_RS16985 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HNO13_RS16995 ENOG4108S4C acetyltransferase HNO13_RS17000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HNO13_RS17010 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HNO13_RS17015 ENOG4105CE4 GlcNAc 6-P deacetylase HNO13_RS17020 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HNO13_RS17030 ENOG4105J7D transcriptional regulator HNO13_RS17035 ENOG41088CQ domain protein HNO13_RS17040 ENOG41086DT Membrane protein of unknown function HNO13_RS17045 ENOG41067S9 phage shock protein C, PspC HNO13_RS17050 ENOG4108PY7 HNO13_RS17065 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HNO13_RS17070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HNO13_RS17085 ENOG4105MKU Transcriptional regulator HNO13_RS17110 ENOG4105CN1 protease HNO13_RS17115 ENOG4108M26 parallel beta-helix repeat protein HNO13_RS17120 ENOG4105CRP Part of the ABC transporter FtsEX involved in HNO13_RS17125 ENOG4105CAK Cell division ATP-binding protein ftsE HNO13_RS17145 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HNO13_RS17150 ENOG4105MS2 ribosomal subunit Interface protein HNO13_RS17165 ENOG4105MQ3 flagellar protein FliS HNO13_RS17170 ENOG4107RT6 flagellar hook-associated HNO13_RS17175 ENOG4105I03 Flagellin HNO13_RS17180 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HNO13_RS17185 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HNO13_RS17195 ENOG4105DTJ flagellar hook-associated protein HNO13_RS17200 ENOG4105E1Q flagellar hook-associated protein HNO13_RS17215 ENOG4105RU3 HNO13_RS17220 ENOG41081UC Inherit from COG: Competence protein HNO13_RS17240 ENOG4105WH1 Two component transcriptional regulator luxr family HNO13_RS17245 ENOG4105BZU Histidine kinase HNO13_RS17250 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HNO13_RS17255 ENOG4108KGH TRANSCRIPTIONal HNO13_RS17260 ENOG4105ESV Glycosyl transferase, family 4 HNO13_RS17265 ENOG4107EF8 Glycosyl transferase (Group 1 HNO13_RS17280 ENOG4105QZI O-Antigen Polymerase HNO13_RS17285 ENOG4105C6Y Udp-glucose 6-dehydrogenase HNO13_RS17290 ENOG4107RA4 Glycosyl transferase (Group 1 HNO13_RS17295 ENOG4105PSV Polysaccharide Biosynthesis Protein HNO13_RS17300 ENOG4105D3Q Sugar transferase HNO13_RS17305 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HNO13_RS17310 ENOG4105JFG SpoIID LytB domain protein HNO13_RS17325 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HNO13_RS17330 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HNO13_RS17335 ENOG4105EY8 ABC transporter HNO13_RS17345 ENOG4107SJB teichoic acid biosynthesis HNO13_RS17355 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HNO13_RS17365 ENOG4107RZX Teichoic acid biosynthesis protein HNO13_RS17375 ENOG4105DG6 mannose-6-phosphate isomerase HNO13_RS17390 ENOG4108NHD germination protein HNO13_RS17395 ENOG4107R8N Glycosyl transferase, family 2 HNO13_RS17400 ENOG4105C54 Major Facilitator superfamily HNO13_RS17405 ENOG4108KGH TRANSCRIPTIONal HNO13_RS17410 ENOG4105J7I hydrolase HNO13_RS17415 ENOG4106UBQ HNO13_RS17420 ENOG4105K4H Nlp p60 protein HNO13_RS17430 ENOG4105PNM synthesis protein HNO13_RS17440 ENOG4105N98 Capsule biosynthesis protein capB HNO13_RS17445 ENOG4105E1K spore germination protein HNO13_RS17460 ENOG4105ETE Transcriptional regulator (LacI family HNO13_RS17465 ENOG4108RVA ribokinase HNO13_RS17470 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HNO13_RS17475 ENOG4105C2J ABC transporter HNO13_RS17480 ENOG4105CNN ABC, transporter HNO13_RS17485 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HNO13_RS17495 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HNO13_RS17500 ENOG4107FQX Alpha-acetolactate decarboxylase HNO13_RS17510 ENOG4107RSM transcriptional regulator HNO13_RS17525 ENOG4106UIA HNO13_RS17540 ENOG4107XC4 flavin reductase domain protein, FMN-binding HNO13_RS17550 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HNO13_RS17560 ENOG4105CAH Chromate HNO13_RS17565 ENOG4105FGV Chromate HNO13_RS17575 ENOG4108WS4 fmn reductase HNO13_RS17580 ENOG4107V2S Transcriptional regulator HNO13_RS17585 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HNO13_RS17635 ENOG4108XI2 Domain of unknown function (DUF1963) HNO13_RS17640 ENOG4105C6Y Udp-glucose 6-dehydrogenase HNO13_RS17645 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HNO13_RS17650 ENOG4107YJ4 chain length determinant protein HNO13_RS17655 ENOG4105HTX biosynthesis protein HNO13_RS17665 ENOG4105KBK Zinc finger, swim domain protein HNO13_RS17670 ENOG4105C0D helicase HNO13_RS17675 ENOG410667J hydrolase HNO13_RS17680 ENOG4105E98 transcriptional regulator DeoR family HNO13_RS17685 ENOG4105Z8H single-stranded DNA-binding protein HNO13_RS17700 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HNO13_RS17705 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HNO13_RS17715 ENOG4105CGA flagellar basal-body rod protein FlgG HNO13_RS17725 ENOG4105DFF Rod shape-determining protein mreb HNO13_RS17730 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HNO13_RS17735 ENOG4107MII Sugar-specific transcriptional regulator TrmB HNO13_RS17740 ENOG4105CZM Major Facilitator HNO13_RS17745 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HNO13_RS17750 ENOG41080V3 Major Facilitator superfamily HNO13_RS17755 ENOG4105D3W isochorismatase HNO13_RS17760 ENOG4105BZU Histidine kinase HNO13_RS17770 ENOG4105CNI cell division protein FtsW HNO13_RS17775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HNO13_RS17785 ENOG4105FRN stage II sporulation protein HNO13_RS17790 ENOG4107TCE N-acetyltransferase HNO13_RS17805 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HNO13_RS17810 ENOG4106BRK HNO13_RS17815 ENOG4107T94 Endo-14-beta-xylanase HNO13_RS17825 ENOG4108Z40 Transcriptional regulator HNO13_RS17830 ENOG4105CQM Urea amidohydrolase subunit alpha HNO13_RS17835 ENOG4105KI2 Urea amidohydrolase subunit beta HNO13_RS17840 ENOG4108YZ9 Urea amidohydrolase subunit gamma HNO13_RS17860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HNO13_RS17865 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HNO13_RS17875 ENOG4108TF4 von Willebrand factor, type A HNO13_RS17890 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HNO13_RS17900 ENOG4106778 Protein of unknown function (DUF1146) HNO13_RS17910 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HNO13_RS17915 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HNO13_RS17920 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HNO13_RS17925 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HNO13_RS17930 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HNO13_RS17945 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HNO13_RS17955 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HNO13_RS17960 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HNO13_RS17965 ENOG4108UIC UPF0340 protein HNO13_RS17970 ENOG4108YZG isomerase HNO13_RS17975 ENOG4107WAU Protein tyrosine phosphatase HNO13_RS17980 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HNO13_RS17985 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HNO13_RS17995 ENOG4108ZXQ stage ii sporulation protein r HNO13_RS18010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HNO13_RS18015 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HNO13_RS18020 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HNO13_RS18030 ENOG4107TT2 Auxin Efflux Carrier HNO13_RS18035 ENOG4105C6K Malic enzyme HNO13_RS18040 ENOG4107104 thymidine kinase HNO13_RS18050 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HNO13_RS18055 ENOG4105CBT Fructose-1,6-bisphosphatase HNO13_RS18060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HNO13_RS18070 ENOG4105D2N Aldolase HNO13_RS18075 ENOG410812K response regulator receiver protein HNO13_RS18085 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HNO13_RS18095 ENOG4105DF6 Fe-S oxidoreductase HNO13_RS18105 ENOG4105E5J UV damage endonuclease HNO13_RS18120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HNO13_RS18135 ENOG4105R3A Nitrate reductase HNO13_RS18140 ENOG4108IUE nitrate reductase beta subunit HNO13_RS18160 ENOG4107V6Q Cyclic nucleotide-binding domain HNO13_RS18170 ENOG4105C75 arginyL-tRNA synthetase HNO13_RS18175 ENOG410684U Domain of unknown function (DUF1934) HNO13_RS18180 ENOG4107JM4 Tetratricopeptide repeat HNO13_RS18220 ENOG4105C75 arginyL-tRNA synthetase HNO13_RS18225 ENOG4105CYW agmatinase HNO13_RS18230 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HNO13_RS18235 ENOG4105BZ4 penicillin-binding protein HNO13_RS18245 ENOG4108XFG YwhD family HNO13_RS18250 ENOG4108Z4T Peptidase M50 HNO13_RS18255 ENOG41069HH 4-oxalocrotonate tautomerase HNO13_RS18260 ENOG41067TZ transcriptional regulator, MarR family HNO13_RS18265 ENOG4105CUB amino acid HNO13_RS18275 ENOG4105DCI Phosphohydrolase HNO13_RS18285 ENOG4108VCI transcription factor, rsfa family HNO13_RS18290 ENOG4105K7K Transcriptional regulator HNO13_RS18305 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HNO13_RS18310 ENOG4105DUM transcriptional regulator, lysR family HNO13_RS18315 ENOG4105HMI Membrane HNO13_RS18320 ENOG4108IJ2 phosphate acetyltransferase HNO13_RS18325 ENOG4107JTW chlorite dismutase HNO13_RS18335 ENOG4105CHM Aminotransferase HNO13_RS18365 ENOG4105FCW Major Facilitator superfamily HNO13_RS18370 ENOG4105C2C drug resistance transporter, Bcr CflA HNO13_RS18385 ENOG4105C26 Dehydrogenase HNO13_RS18390 ENOG4105D82 Glutamate dehydrogenase HNO13_RS18400 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HNO13_RS18405 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HNO13_RS18410 ENOG4105C1B dTDP-glucose 4-6-dehydratase HNO13_RS18415 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HNO13_RS18420 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HNO13_RS18425 ENOG4107TY6 Acylneuraminate cytidylyltransferase HNO13_RS18435 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HNO13_RS18440 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HNO13_RS18475 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HNO13_RS18480 ENOG4108RJ9 Glycosyl transferase, family 2 HNO13_RS18500 ENOG4105DWF phosphomethylpyrimidine kinase HNO13_RS18515 ENOG4105C5Y PTS System HNO13_RS18530 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HNO13_RS18535 ENOG4105DEN Luciferase family HNO13_RS18540 ENOG4108DBC nitroreductase HNO13_RS18550 ENOG4105I4A GCN5-related N-acetyltransferase HNO13_RS18570 ENOG4105BZ9 Cytochrome C oxidase, subunit I HNO13_RS18575 ENOG4105E2S oxidase) subunit II HNO13_RS18580 ENOG4107BMA Transglycosylase associated protein HNO13_RS18595 ENOG4105WH5 Teichoic acid glycosylation protein HNO13_RS18620 ENOG4107ZXU DSBA oxidoreductase HNO13_RS18625 ENOG4105DBE peroxidase HNO13_RS18640 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HNO13_RS18645 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HNO13_RS18650 ENOG4105CMU LysR family (Transcriptional regulator HNO13_RS18655 ENOG4105VAW lrga family HNO13_RS18660 ENOG41067MG lrgb family HNO13_RS18670 ENOG4107TXC Transcriptional regulator HNO13_RS18675 ENOG4105DR4 Methyltransferase HNO13_RS18685 ENOG4105CK1 PTS System HNO13_RS18690 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HNO13_RS18695 ENOG4105X1N Glycosyl transferase family 8 HNO13_RS18705 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HNO13_RS18715 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HNO13_RS18720 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HNO13_RS18725 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HNO13_RS18730 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HNO13_RS18735 ENOG4105CM2 brancheD-chain amino acid aminotransferase HNO13_RS18740 ENOG4105F8D glycoside hydrolase family 4 HNO13_RS18745 ENOG4105VCP PTS System HNO13_RS18750 ENOG4105CK1 PTS System HNO13_RS18755 ENOG4105VZJ PTS System HNO13_RS18760 ENOG4105EMD TRANSCRIPTIONal HNO13_RS18770 ENOG4105DQ5 transport system permease protein HNO13_RS18775 ENOG4105EHG Permease protein HNO13_RS18785 ENOG41082YX Transcriptional regulator, arsr family HNO13_RS18790 ENOG4107R5R arsenical pump membrane protein HNO13_RS18795 ENOG4105VZJ PTS System HNO13_RS18800 ENOG4105VCP PTS System HNO13_RS18805 ENOG4105CK1 PTS System HNO13_RS18810 ENOG4105CS2 ec 3.2.1.21 HNO13_RS18815 ENOG4105EVU fructokinase HNO13_RS18820 ENOG4105DG6 mannose-6-phosphate isomerase HNO13_RS18830 ENOG4105CH6 catalase HNO13_RS18835 ENOG4107QHE Choloylglycine hydrolase HNO13_RS18840 ENOG4105ETS cytosine purines uracil thiamine allantoin HNO13_RS18845 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HNO13_RS18850 ENOG4108JJ8 (ABC) transporter HNO13_RS18855 ENOG4108JJ9 ABC, transporter HNO13_RS18860 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HNO13_RS18865 ENOG4105C4M (Ubiquinol oxidase) subunit I HNO13_RS18870 ENOG4105D2K citrate carrier protein HNO13_RS18875 ENOG4107BJW polysaccharide deacetylase HNO13_RS18890 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HNO13_RS18900 ENOG4105CMR udp-glucose 4-epimerase HNO13_RS18905 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HNO13_RS18925 ENOG4105DHI Methyltransferase HNO13_RS18945 ENOG4105CH6 catalase HNO13_RS18950 ENOG4105D4T Citrate transporter HNO13_RS18965 ENOG4105DEU major facilitator superfamily HNO13_RS18970 ENOG4105C1J atp-dependent rna helicase HNO13_RS19030 ENOG4108NR7 pectate lyase HNO13_RS19040 ENOG4107YZX Universal stress protein HNO13_RS19105 ENOG4106Z5D Glycoside Hydrolase Family 43 HNO13_RS19115 ENOG4105C84 Histidine ammonia-lyase HNO13_RS19120 ENOG4105CGP Urocanate hydratase HNO13_RS19125 ENOG4105CI2 imidazolone-5-propionate hydrolase HNO13_RS19130 ENOG4107W25 arginase agmatinase formiminoglutamase HNO13_RS19140 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HNO13_RS19145 ENOG4105D9N nucleoside HNO13_RS19150 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HNO13_RS19155 ENOG4107RHR regulatoR HNO13_RS19160 ENOG410667J hydrolase HNO13_RS19190 ENOG4108V5C ABC transporter HNO13_RS19225 ENOG4105WZ4 isomerase HNO13_RS19230 ENOG4105F0H myo-inositol catabolism protein HNO13_RS19235 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HNO13_RS19245 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HNO13_RS19255 ENOG4105EDK PfkB domain protein HNO13_RS19265 ENOG4105C26 Dehydrogenase HNO13_RS19275 ENOG4105CPC Aldo Keto reductase HNO13_RS19280 ENOG4107QNK )-transporter HNO13_RS19285 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HNO13_RS19290 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HNO13_RS19295 ENOG4108S01 response regulator HNO13_RS19300 ENOG4108ZGX Histidine kinase HNO13_RS19305 ENOG4105ECK Fatty Acid Desaturase HNO13_RS19310 ENOG4105ST3 Transcriptional regulator HNO13_RS19315 ENOG4105C26 Dehydrogenase HNO13_RS19320 ENOG4108ITS PQQ enzyme repeat HNO13_RS19330 ENOG4105WAB arsR family transcriptional regulator HNO13_RS19335 ENOG4105F27 Major Facilitator HNO13_RS19340 ENOG41085PJ rdd domain containing protein HNO13_RS19350 ENOG4105D3R alkyl hydroperoxide reductase HNO13_RS19355 ENOG4108JU3 Alkyl hydroperoxide reductase HNO13_RS19360 ENOG4105C85 amino acid HNO13_RS19365 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HNO13_RS19370 ENOG4108XHQ (2Fe-2S)-binding domain protein HNO13_RS19390 ENOG4105XRQ Xanthine dehydrogenase accessory factor HNO13_RS19410 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HNO13_RS19430 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HNO13_RS19435 ENOG4105CPC Aldo Keto reductase HNO13_RS19440 ENOG4105WQG acetyltransferase HNO13_RS19450 ENOG41066UZ arginase EC 3.5.3.1 HNO13_RS19455 ENOG4108IQI permease HNO13_RS19460 ENOG4105C8Y Acetylornithine aminotransferase HNO13_RS19465 ENOG4108JUB Transcriptional regulator HNO13_RS19475 ENOG4105C5H ABC transporter HNO13_RS19490 ENOG4105D06 uba thif-type nad fad binding protein HNO13_RS19495 ENOG41062D9 Histidine kinase HNO13_RS19500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS19505 ENOG4105C0H protease HNO13_RS19510 ENOG4105Q2H domain protein HNO13_RS19525 ENOG4105BZU Histidine kinase HNO13_RS19530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HNO13_RS19555 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HNO13_RS19560 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HNO13_RS19565 ENOG4105CDU Replicative dna helicase HNO13_RS19585 ENOG4107QPH glycogen) synthase HNO13_RS19595 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HNO13_RS19600 ENOG4105CPK Glycosyl transferase (Group 1 HNO13_RS19620 ENOG4105BZR domain protein HNO13_RS19625 ENOG4108XMW Membrane HNO13_RS19640 ENOG4105KVH Transcriptional regulator HNO13_RS19645 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HNO13_RS19650 ENOG4108UZ3 Transporter HNO13_RS19655 ENOG4105EDQ levansucrase EC 2.4.1.10 HNO13_RS19660 ENOG4108HKT sucrose-6-phosphate hydrolase HNO13_RS19665 ENOG4107XBN GntR Family Transcriptional Regulator HNO13_RS19685 ENOG4108TVJ Nitroreductase HNO13_RS19690 ENOG4105FS7 Transcriptional regulator HNO13_RS19700 ENOG4108U05 Transcriptional regulator HNO13_RS19715 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HNO13_RS19720 ENOG4105CMU LysR family (Transcriptional regulator HNO13_RS19725 ENOG4105DTD Dehydrogenase HNO13_RS19735 ENOG4107Y9U Membrane HNO13_RS19750 ENOG410847I Transcriptional regulator, BadM Rrf2 family HNO13_RS19755 ENOG4108IMY Transcriptional regulator HNO13_RS19765 ENOG4105C7Z Conserved Protein HNO13_RS19770 ENOG4107FCW Abortive infection protein HNO13_RS19780 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HNO13_RS19790 ENOG4105CGK Exodeoxyribonuclease III HNO13_RS19795 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HNO13_RS19805 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HNO13_RS19810 ENOG4108UUM single-stranded DNA-binding protein HNO13_RS19815 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HNO13_RS19820 ENOG4105C3G gtp-binding protein HNO13_RS19825 ENOG4108J2R molybdopterin oxidoreductase HNO13_RS19830 ENOG4105VDK protein, conserved in bacteria HNO13_RS19845 ENOG4108ZDA Sporulation protein YyaC HNO13_RS19850 ENOG4105FA0 parb-like partition protein HNO13_RS19855 ENOG4107QJE Chromosome Partitioning Protein HNO13_RS19870 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HNO13_RS19875 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HNO13_RS19890 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)