locus-tag	class	description
H5405_RS00010	COG0187	DNA topoisomerase II activity
H5405_RS00025	COG2501	S4 domain
H5405_RS00030	COG0592	DNA-directed DNA polymerase activity
H5405_RS00050	COG0706	membrane insertase activity
H5405_RS00055	COG1847	R3H domain protein
H5405_RS00080	COG1192	Involved in chromosome partitioning
H5405_RS00085	COG1475	DNA binding
H5405_RS00100	COG3949	Membrane
H5405_RS00105	COG4481	Protein conserved in bacteria
H5405_RS00110	COG0243	molybdopterin cofactor binding
H5405_RS00115	COG0012	GTP binding
H5405_RS00125	COG0629	single-stranded DNA binding
H5405_RS00135	COG2169	Transcriptional regulator
H5405_RS00140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5405_RS00145	COG0708	Exodeoxyribonuclease III
H5405_RS00150	COG1609	Transcriptional regulator
H5405_RS00155	COG0346	lactoylglutathione lyase activity
H5405_RS00160	COG0477	Major facilitator Superfamily
H5405_RS00160	COG2814	Major facilitator Superfamily
H5405_RS00165	COG1266	CAAX protease self-immunity
H5405_RS00170	COG1331	Highly conserved protein containing a thioredoxin domain
H5405_RS00175	COG3621	Patatin-like phospholipase
H5405_RS00180	COG0697	spore germination
H5405_RS00185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS00190	COG1331	Highly conserved protein containing a thioredoxin domain
H5405_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS00205	COG0583	DNA-binding transcription factor activity
H5405_RS00210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5405_RS00220	COG2153	protein acetylation
H5405_RS00225	COG1846	Transcriptional regulator
H5405_RS00230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS00235	COG1846	Transcriptional regulator
H5405_RS00240	COG0778	Nitroreductase
H5405_RS00250	COG2211	Major facilitator Superfamily
H5405_RS00255	COG2318	DinB family
H5405_RS00265	COG1621	beta-fructofuranosidase activity
H5405_RS00270	COG1621	beta-fructofuranosidase activity
H5405_RS00275	COG0697	spore germination
H5405_RS00285	COG1733	regulation of RNA biosynthetic process
H5405_RS00290	COG5577	PFAM Coat F domain
H5405_RS00300	COG4241	membrane
H5405_RS00305	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H5405_RS00325	COG0438	transferase activity, transferring glycosyl groups
H5405_RS00330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H5405_RS00345	COG3093	addiction module antidote protein HigA
H5405_RS00360	COG0305	Participates in initiation and elongation during chromosome replication
H5405_RS00365	COG0346	lactoylglutathione lyase activity
H5405_RS00395	COG0745	RESPONSE REGULATOR receiver
H5405_RS00400	COG5002	protein histidine kinase activity
H5405_RS00405	COG4863	YycH protein
H5405_RS00410	COG4853	Protein conserved in bacteria
H5405_RS00415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5405_RS00420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5405_RS00430	COG5002	protein histidine kinase activity
H5405_RS00435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5405_RS00465	COG0640	Transcriptional regulator
H5405_RS00470	COG5658	integral membrane protein
H5405_RS00475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5405_RS00480	COG0833	amino acid
H5405_RS00485	COG0010	Belongs to the arginase family
H5405_RS00495	COG0456	acetyltransferase
H5405_RS00500	COG0667	Aldo Keto reductase
H5405_RS00505	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H5405_RS00550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H5405_RS00555	COG2068	MobA-Related Protein
H5405_RS00570	COG2080	2 iron, 2 sulfur cluster binding
H5405_RS00580	COG1113	amino acid transport
H5405_RS00585	COG3634	alkyl hydroperoxide reductase activity
H5405_RS00590	COG0450	alkyl hydroperoxide reductase
H5405_RS00600	COG1714	RDD family
H5405_RS00605	COG2814	Major facilitator Superfamily
H5405_RS00610	COG0640	Transcriptional regulator
H5405_RS00620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5405_RS00625	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS00630	COG1309	transcriptional regulator
H5405_RS00635	COG3239	Fatty acid desaturase
H5405_RS00640	COG4585	Histidine kinase
H5405_RS00645	COG2197	response regulator
H5405_RS00650	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS00660	COG2814	Major facilitator Superfamily
H5405_RS00665	COG0667	Aldo Keto reductase
H5405_RS00670	COG1349	DNA-binding transcription factor activity
H5405_RS00700	COG2814	Major facilitator Superfamily
H5405_RS00710	COG1082	Xylose isomerase domain protein TIM barrel
H5405_RS00740	COG0745	RESPONSE REGULATOR receiver
H5405_RS00765	COG0745	RESPONSE REGULATOR receiver
H5405_RS00770	COG2205	protein histidine kinase activity
H5405_RS00775	COG0745	RESPONSE REGULATOR receiver
H5405_RS00780	COG2205	protein histidine kinase activity
H5405_RS00785	COG1136	(ABC) transporter
H5405_RS00790	COG0577	efflux transmembrane transporter activity
H5405_RS00795	COG5294	Protein conserved in bacteria
H5405_RS00800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5405_RS00830	COG0561	phosphatase activity
H5405_RS00835	COG2390	Transcriptional regulator
H5405_RS00845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5405_RS00850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H5405_RS00855	COG0833	amino acid
H5405_RS00860	COG0010	Belongs to the arginase family
H5405_RS00885	COG3507	Belongs to the glycosyl hydrolase 43 family
H5405_RS00905	COG0589	response to stress
H5405_RS00910	COG0697	spore germination
H5405_RS00990	COG0513	Belongs to the DEAD box helicase family
H5405_RS00995	COG2270	Major facilitator Superfamily
H5405_RS01005	COG2273	Hydrolase Family 16
H5405_RS01010	COG2851	Citrate transporter
H5405_RS01015	COG0753	catalase activity
H5405_RS01015	COG0693	protein deglycase activity
H5405_RS01030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5405_RS01035	COG0500	methyltransferase
H5405_RS01040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5405_RS01045	COG4894	glucomannan catabolic process
H5405_RS01060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5405_RS01070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS01080	COG3842	ATPase activity
H5405_RS01085	COG0726	polysaccharide deacetylase
H5405_RS01090	COG3493	citrate carrier protein
H5405_RS01095	COG1271	oxidase subunit
H5405_RS01100	COG1294	oxidase, subunit
H5405_RS01105	COG4988	ABC transporter
H5405_RS01110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H5405_RS01115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5405_RS01120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5405_RS01125	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H5405_RS01130	COG0753	catalase activity
H5405_RS01140	COG1482	cell wall glycoprotein biosynthetic process
H5405_RS01145	COG1940	carbohydrate kinase activity
H5405_RS01150	COG2723	6-phospho-beta-galactosidase activity
H5405_RS01155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS01160	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5405_RS01165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS01170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5405_RS01175	COG0640	Transcriptional regulator
H5405_RS01185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS01190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS01200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS01200	COG3711	transcriptional antiterminator
H5405_RS01205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS01210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS01215	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5405_RS01220	COG1486	melibiose metabolic process
H5405_RS01225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5405_RS01230	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H5405_RS01240	COG1696	Membrane protein involved in D-alanine export
H5405_RS01255	COG1575	Belongs to the MenA family. Type 1 subfamily
H5405_RS01260	COG2357	RelA SpoT domain protein
H5405_RS01265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5405_RS01270	COG1846	Transcriptional regulator
H5405_RS01275	COG1442	glycosyl transferase family 8
H5405_RS01280	COG1404	Belongs to the peptidase S8 family
H5405_RS01285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS01290	COG0346	lactoylglutathione lyase activity
H5405_RS01295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5405_RS01300	COG5504	Zn-dependent protease
H5405_RS01305	COG0789	Transcriptional regulator
H5405_RS01310	COG4895	conserved protein (DUF2196)
H5405_RS01315	COG1346	cytolysis
H5405_RS01325	COG0583	DNA-binding transcription factor activity
H5405_RS01345	COG2837	iron assimilation
H5405_RS01350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H5405_RS01360	COG2813	Specifically methylates the guanine in position
H5405_RS01370	COG1309	transcriptional regulator
H5405_RS01375	COG2246	polysaccharide biosynthetic process
H5405_RS01380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5405_RS01385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H5405_RS01390	COG2261	transglycosylase associated protein
H5405_RS01395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5405_RS01400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5405_RS01420	COG0454	-acetyltransferase
H5405_RS01425	COG0772	Belongs to the SEDS family
H5405_RS01430	COG0778	Nitroreductase
H5405_RS01435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS01440	COG1404	Belongs to the peptidase S8 family
H5405_RS01450	COG3711	transcriptional antiterminator
H5405_RS01455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS01455	COG1263	PTS System
H5405_RS01460	COG1621	beta-fructofuranosidase activity
H5405_RS01470	COG0351	phosphomethylpyrimidine kinase
H5405_RS01475	COG1695	Transcriptional regulator
H5405_RS01490	COG1216	Glycosyl transferase, family 2
H5405_RS01505	COG2233	PERMEase
H5405_RS01510	COG2363	Small membrane protein
H5405_RS01520	COG0463	Glycosyl transferase, family 2
H5405_RS01525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5405_RS01530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5405_RS01535	COG0456	acetyltransferase
H5405_RS01540	COG2089	acid synthase
H5405_RS01545	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H5405_RS01550	COG3980	spore coat polysaccharide biosynthesis protein
H5405_RS01555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H5405_RS01560	COG1088	dTDP-glucose 4,6-dehydratase activity
H5405_RS01565	COG1091	dTDP-4-dehydrorhamnose reductase activity
H5405_RS01570	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H5405_RS01575	COG1131	(ABC) transporter
H5405_RS01590	COG0745	RESPONSE REGULATOR receiver
H5405_RS01595	COG2205	protein histidine kinase activity
H5405_RS01600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5405_RS01605	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS01610	COG4187	Peptidase family M20/M25/M40
H5405_RS01615	COG0833	amino acid
H5405_RS01620	COG2814	Major facilitator Superfamily
H5405_RS01625	COG2814	Major facilitator Superfamily
H5405_RS01655	COG0436	Aminotransferase
H5405_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS01670	COG0280	phosphate acetyltransferase
H5405_RS01675	COG2855	membrane
H5405_RS01680	COG0583	DNA-binding transcription factor activity
H5405_RS01710	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H5405_RS01715	COG1131	(ABC) transporter
H5405_RS01725	COG1695	Transcriptional regulator
H5405_RS01740	COG1078	dGTPase activity
H5405_RS01745	COG3465	dGTPase activity
H5405_RS01750	COG0531	amino acid
H5405_RS01755	COG1846	Transcriptional regulator
H5405_RS01760	COG1942	4-Oxalocrotonate Tautomerase
H5405_RS01765	COG1994	Peptidase M50
H5405_RS01780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5405_RS01785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H5405_RS01790	COG0010	Belongs to the arginase family
H5405_RS01830	COG0457	Tetratricopeptide repeat
H5405_RS01835	COG3391	amine dehydrogenase activity
H5405_RS01840	COG3391	amine dehydrogenase activity
H5405_RS01850	COG4506	Protein conserved in bacteria
H5405_RS01860	COG2223	nitrite transmembrane transporter activity
H5405_RS01865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5405_RS01875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5405_RS01880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H5405_RS01885	COG1140	nitrate reductase beta subunit
H5405_RS01890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H5405_RS01895	COG2181	nitrate reductase activity
H5405_RS01910	COG1132	(ABC) transporter
H5405_RS01925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5405_RS01930	COG0247	lactate metabolic process
H5405_RS01930	COG2181	nitrate reductase activity
H5405_RS01945	COG4821	SIS domain
H5405_RS01950	COG2204	response regulator
H5405_RS01955	COG0191	fructose-bisphosphate aldolase activity
H5405_RS01965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5405_RS01970	COG1494	fructose-1,6-bisphosphatase
H5405_RS01975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5405_RS01990	COG0281	malic enzyme
H5405_RS01995	COG0679	Auxin Efflux Carrier
H5405_RS02000	COG0789	Transcriptional regulator
H5405_RS02005	COG0346	lactoylglutathione lyase activity
H5405_RS02010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5405_RS02015	COG2890	protein-(glutamine-N5) methyltransferase activity
H5405_RS02035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5405_RS02040	COG0009	L-threonylcarbamoyladenylate synthase
H5405_RS02050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5405_RS02055	COG0698	ribose 5-phosphate isomerase
H5405_RS02125	COG4836	Membrane
H5405_RS02135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5405_RS02140	COG2385	sporulation resulting in formation of a cellular spore
H5405_RS02145	COG2304	oxidoreductase activity
H5405_RS02150	COG2304	oxidoreductase activity
H5405_RS02160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5405_RS02170	COG0457	Tetratricopeptide repeat
H5405_RS02175	COG1994	Peptidase M50
H5405_RS02180	COG3237	CsbD-like
H5405_RS02185	COG0831	urea catabolic process
H5405_RS02200	COG1959	2 iron, 2 sulfur cluster binding
H5405_RS02210	COG0726	polysaccharide deacetylase
H5405_RS02220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5405_RS02235	COG1247	-acetyltransferase
H5405_RS02240	COG0739	heme binding
H5405_RS02250	COG0671	phosphoesterase, PA-phosphatase related
H5405_RS02255	COG0772	Belongs to the SEDS family
H5405_RS02260	COG0347	Belongs to the P(II) protein family
H5405_RS02265	COG0004	ammonium transporteR
H5405_RS02270	COG1335	isochorismatase
H5405_RS02275	COG0477	Major facilitator Superfamily
H5405_RS02280	COG1953	Uracil, thiamine, allantoin
H5405_RS02285	COG2814	Major facilitator Superfamily
H5405_RS02290	COG1846	Transcriptional regulator
H5405_RS02295	COG1609	Transcriptional regulator
H5405_RS02300	COG1077	Cell shape determining protein MreB Mrl
H5405_RS02305	COG4786	Flagellar basal body rod
H5405_RS02310	COG4786	Flagellar basal body rod
H5405_RS02315	COG0457	Tetratricopeptide repeat
H5405_RS02340	COG0629	single-stranded DNA binding
H5405_RS02345	COG1349	DNA-binding transcription factor activity
H5405_RS02350	COG0561	phosphatase activity
H5405_RS02355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5405_RS02370	COG3944	biosynthesis protein
H5405_RS02375	COG0489	protein tyrosine kinase activity
H5405_RS02380	COG4464	protein tyrosine phosphatase activity
H5405_RS02385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H5405_RS02390	COG3878	Protein conserved in bacteria
H5405_RS02435	COG0583	DNA-binding transcription factor activity
H5405_RS02440	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5405_RS02450	COG2059	Chromate
H5405_RS02455	COG2059	Chromate
H5405_RS02460	COG1522	sequence-specific DNA binding
H5405_RS02465	COG0405	Gamma-glutamyltransferase
H5405_RS02475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5405_RS02485	COG5337	Spore coat protein CotH
H5405_RS02500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5405_RS02505	COG0583	DNA-binding transcription factor activity
H5405_RS02510	COG0028	Belongs to the TPP enzyme family
H5405_RS02515	COG3527	Alpha-acetolactate decarboxylase
H5405_RS02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5405_RS02525	COG3103	Sh3 type 3 domain protein
H5405_RS02530	COG1879	ABC-type sugar transport system periplasmic component
H5405_RS02535	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5405_RS02540	COG1129	ABC transporter
H5405_RS02550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5405_RS02555	COG1609	Transcriptional regulator
H5405_RS02565	COG0814	amino acid
H5405_RS02570	COG0697	spore germination
H5405_RS02575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5405_RS02585	COG2843	Capsule synthesis protein
H5405_RS02595	COG0791	NLP P60 protein
H5405_RS02600	COG2433	Pfam Transposase IS66
H5405_RS02605	COG0561	phosphatase activity
H5405_RS02610	COG1316	TRANSCRIPTIONal
H5405_RS02615	COG2814	Major facilitator Superfamily
H5405_RS02620	COG1215	transferase activity, transferring glycosyl groups
H5405_RS02630	COG0814	amino acid
H5405_RS02635	COG0697	spore germination
H5405_RS02640	COG1482	cell wall glycoprotein biosynthetic process
H5405_RS02650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5405_RS02655	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H5405_RS02660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H5405_RS02670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5405_RS02675	COG1682	transport, permease protein
H5405_RS02680	COG1134	teichoic acid transport
H5405_RS02685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5405_RS02690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H5405_RS02695	COG1316	TRANSCRIPTIONal
H5405_RS02705	COG2247	cell wall binding repeat
H5405_RS02705	COG2385	sporulation resulting in formation of a cellular spore
H5405_RS02710	COG2247	cell wall binding repeat
H5405_RS02710	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS02720	COG2244	polysaccharide biosynthetic process
H5405_RS02725	COG0297	glycogen (starch) synthase activity
H5405_RS02725	COG0438	transferase activity, transferring glycosyl groups
H5405_RS02730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H5405_RS02735	COG3307	-O-antigen
H5405_RS02740	COG3206	protein involved in exopolysaccharide biosynthesis
H5405_RS02745	COG1215	transferase activity, transferring glycosyl groups
H5405_RS02750	COG0438	transferase activity, transferring glycosyl groups
H5405_RS02755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5405_RS02760	COG1316	TRANSCRIPTIONal
H5405_RS02765	COG1739	Uncharacterized protein family UPF0029
H5405_RS02770	COG4585	Histidine kinase
H5405_RS02775	COG2197	response regulator
H5405_RS02780	COG1307	EDD domain protein, DegV family
H5405_RS02785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H5405_RS02795	COG1040	competence protein
H5405_RS02805	COG2747	anti-sigma28 factor FlgM
H5405_RS02810	COG3418	PFAM FlgN family protein
H5405_RS02815	COG4786	Flagellar basal body rod
H5405_RS02815	COG1256	bacterial-type flagellum assembly
H5405_RS02820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5405_RS02840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5405_RS02845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5405_RS02850	COG1516	flagellar protein fliS
H5405_RS02865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5405_RS02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS02885	COG2010	Cytochrome c
H5405_RS02890	COG2884	Cell division ATP-binding protein ftsE
H5405_RS02895	COG2177	Part of the ABC transporter FtsEX involved in
H5405_RS02900	COG3420	alginic acid biosynthetic process
H5405_RS02905	COG0793	Belongs to the peptidase S41A family
H5405_RS02905	COG3409	Peptidoglycan-binding domain 1 protein
H5405_RS02915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5405_RS02940	COG2814	Major facilitator Superfamily
H5405_RS02945	COG1309	transcriptional regulator
H5405_RS02950	COG0574	Belongs to the PEP-utilizing enzyme family
H5405_RS02950	COG3848	Pyruvate phosphate dikinase
H5405_RS02955	COG4897	Protein conserved in bacteria
H5405_RS02965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5405_RS02980	COG3595	metallopeptidase activity
H5405_RS02985	COG1983	PspC domain protein
H5405_RS02990	COG1950	PFAM Membrane protein of
H5405_RS02995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5405_RS03000	COG1309	transcriptional regulator
H5405_RS03005	COG2188	Transcriptional regulator
H5405_RS03015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5405_RS03035	COG0110	maltose O-acetyltransferase activity
H5405_RS03040	COG4990	cell redox homeostasis
H5405_RS03055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5405_RS03080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5405_RS03080	COG0140	phosphoribosyl-ATP diphosphatase activity
H5405_RS03085	COG1132	(ABC) transporter
H5405_RS03090	COG0745	RESPONSE REGULATOR receiver
H5405_RS03100	COG0457	Tetratricopeptide repeat
H5405_RS03105	COG0791	NLP P60 protein
H5405_RS03105	COG3883	PFAM NLP P60 protein
H5405_RS03110	COG0492	ferredoxin-NADP+ reductase activity
H5405_RS03115	COG1051	belongs to the nudix hydrolase family
H5405_RS03125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H5405_RS03135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS03140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H5405_RS03145	COG4290	ribonuclease
H5405_RS03150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5405_RS03155	COG0288	reversible hydration of carbon dioxide
H5405_RS03160	COG0659	secondary active sulfate transmembrane transporter activity
H5405_RS03165	COG1694	Mazg nucleotide pyrophosphohydrolase
H5405_RS03170	COG1611	Belongs to the LOG family
H5405_RS03175	COG2814	Major facilitator Superfamily
H5405_RS03175	COG0477	Major facilitator Superfamily
H5405_RS03180	COG2828	Protein conserved in bacteria
H5405_RS03185	COG0583	DNA-binding transcription factor activity
H5405_RS03195	COG1609	Transcriptional regulator
H5405_RS03200	COG2223	nitrite transmembrane transporter activity
H5405_RS03250	COG3479	Phenolic acid decarboxylase
H5405_RS03255	COG0456	acetyltransferase
H5405_RS03260	COG2364	Membrane
H5405_RS03265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5405_RS03275	COG2272	Belongs to the type-B carboxylesterase lipase family
H5405_RS03280	COG1396	sequence-specific DNA binding
H5405_RS03285	COG3944	biosynthesis protein
H5405_RS03290	COG0489	protein tyrosine kinase activity
H5405_RS03295	COG1086	Polysaccharide biosynthesis protein
H5405_RS03300	COG0438	transferase activity, transferring glycosyl groups
H5405_RS03305	COG1215	transferase activity, transferring glycosyl groups
H5405_RS03310	COG0438	transferase activity, transferring glycosyl groups
H5405_RS03320	COG1216	Glycosyl transferase, family 2
H5405_RS03325	COG5039	Polysaccharide pyruvyl transferase
H5405_RS03330	COG1216	Glycosyl transferase, family 2
H5405_RS03335	COG2244	polysaccharide biosynthetic process
H5405_RS03340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5405_RS03345	COG0110	maltose O-acetyltransferase activity
H5405_RS03350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5405_RS03355	COG5039	Polysaccharide pyruvyl transferase
H5405_RS03365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H5405_RS03370	COG1620	l-lactate permease
H5405_RS03375	COG2186	Transcriptional regulator
H5405_RS03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS03405	COG1070	Carbohydrate kinase
H5405_RS03410	COG1737	Transcriptional regulator
H5405_RS03420	COG1113	amino acid transport
H5405_RS03425	COG0697	spore germination
H5405_RS03430	COG0583	DNA-binding transcription factor activity
H5405_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS03445	COG1609	Transcriptional regulator
H5405_RS03450	COG2814	Major facilitator Superfamily
H5405_RS03455	COG2390	Transcriptional regulator
H5405_RS03460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5405_RS03465	COG0126	phosphoglycerate kinase activity
H5405_RS03485	COG2234	aminopeptidase activity
H5405_RS03495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5405_RS03500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS03520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H5405_RS03535	COG0456	acetyltransferase
H5405_RS03540	COG4640	response to antibiotic
H5405_RS03550	COG2095	MarC family integral membrane protein
H5405_RS03555	COG1510	regulation of RNA biosynthetic process
H5405_RS03560	COG0517	IMP dehydrogenase activity
H5405_RS03560	COG1125	glycine betaine transport
H5405_RS03565	COG1174	glycine betaine transport
H5405_RS03570	COG1732	Glycine betaine
H5405_RS03575	COG1174	glycine betaine transport
H5405_RS03580	COG1510	regulation of RNA biosynthetic process
H5405_RS03585	COG0517	IMP dehydrogenase activity
H5405_RS03585	COG1125	glycine betaine transport
H5405_RS03590	COG1174	glycine betaine transport
H5405_RS03595	COG1732	Glycine betaine
H5405_RS03600	COG1174	glycine betaine transport
H5405_RS03605	COG1131	(ABC) transporter
H5405_RS03630	COG1733	regulation of RNA biosynthetic process
H5405_RS03635	COG1396	sequence-specific DNA binding
H5405_RS03640	COG1396	sequence-specific DNA binding
H5405_RS03645	COG1476	TRANSCRIPTIONal
H5405_RS03650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5405_RS03655	COG1647	Serine aminopeptidase, S33
H5405_RS03660	COG0557	exoribonuclease II activity
H5405_RS03675	COG2732	(Barnase) inhibitor
H5405_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS03685	COG0583	DNA-binding transcription factor activity
H5405_RS03690	COG0454	-acetyltransferase
H5405_RS03695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS03705	COG0765	amino acid transport
H5405_RS03710	COG0765	amino acid transport
H5405_RS03715	COG1126	abc transporter atp-binding protein
H5405_RS03720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS03725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5405_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS03740	COG0673	inositol 2-dehydrogenase activity
H5405_RS03745	COG1937	Protein conserved in bacteria
H5405_RS03750	COG2608	mercury ion transmembrane transporter activity
H5405_RS03755	COG2217	Heavy metal translocating P-type atpase
H5405_RS03760	COG2217	Heavy metal translocating P-type atpase
H5405_RS03765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5405_RS03770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5405_RS03780	COG2860	membrane
H5405_RS03785	COG3973	AAA domain
H5405_RS03790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5405_RS03810	COG0656	L-ascorbic acid biosynthetic process
H5405_RS03815	COG0842	Transport permease protein
H5405_RS03825	COG1131	(ABC) transporter
H5405_RS03830	COG3850	Histidine kinase
H5405_RS03835	COG2197	response regulator
H5405_RS03840	COG4149	molybdate abc transporter
H5405_RS03845	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5405_RS03850	COG1910	domain protein
H5405_RS03855	COG1368	sulfuric ester hydrolase activity
H5405_RS03860	COG1988	membrane-bound metal-dependent
H5405_RS03870	COG0531	amino acid
H5405_RS03875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5405_RS03880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS03885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS03890	COG1120	ATPase activity
H5405_RS03900	COG2140	Oxalate decarboxylase
H5405_RS03910	COG1191	sigma factor activity
H5405_RS03920	COG0745	RESPONSE REGULATOR receiver
H5405_RS03925	COG2205	protein histidine kinase activity
H5405_RS03930	COG3386	PFAM SMP-30 Gluconolaconase
H5405_RS03935	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS03940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5405_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS03950	COG1120	ATPase activity
H5405_RS03955	COG2096	Adenosyltransferase
H5405_RS03960	COG2814	Major facilitator Superfamily
H5405_RS03965	COG4758	membrane
H5405_RS03970	COG1842	Phage shock protein A
H5405_RS03975	COG3595	metallopeptidase activity
H5405_RS03980	COG4758	membrane
H5405_RS03985	COG4585	Histidine kinase
H5405_RS03990	COG2197	response regulator
H5405_RS04000	COG0814	amino acid
H5405_RS04005	COG0697	spore germination
H5405_RS04015	COG0114	fumarate hydratase activity
H5405_RS04020	COG1309	transcriptional regulator
H5405_RS04030	COG2205	protein histidine kinase activity
H5405_RS04030	COG2770	Histidine kinase
H5405_RS04035	COG0745	RESPONSE REGULATOR receiver
H5405_RS04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5405_RS04045	COG0783	Belongs to the Dps family
H5405_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS04065	COG1120	ATPase activity
H5405_RS04085	COG0583	DNA-binding transcription factor activity
H5405_RS04090	COG0477	Major facilitator Superfamily
H5405_RS04095	COG1846	Transcriptional regulator
H5405_RS04100	COG5577	PFAM Coat F domain
H5405_RS04120	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5405_RS04120	COG1024	Enoyl-CoA hydratase
H5405_RS04125	COG0183	Belongs to the thiolase family
H5405_RS04130	COG1960	acyl-CoA dehydrogenase activity
H5405_RS04135	COG1393	Belongs to the ArsC family
H5405_RS04150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H5405_RS04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS04165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5405_RS04170	COG2011	ABC-type metal ion transport system permease component
H5405_RS04175	COG1464	Belongs to the NlpA lipoprotein family
H5405_RS04180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5405_RS04190	COG0396	ATPase activity
H5405_RS04195	COG0719	Fe-S assembly protein
H5405_RS04200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5405_RS04205	COG0822	iron-sulfur transferase activity
H5405_RS04210	COG0719	Fe-S assembly protein
H5405_RS04215	COG3409	Peptidoglycan-binding domain 1 protein
H5405_RS04225	COG2226	methyltransferase
H5405_RS04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5405_RS04235	COG0322	excinuclease ABC activity
H5405_RS04245	COG2222	sugar isomerase
H5405_RS04250	COG1653	transport
H5405_RS04255	COG1175	transmembrane transport
H5405_RS04260	COG0395	ABC-type sugar transport system, permease component
H5405_RS04265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5405_RS04270	COG2188	Transcriptional regulator
H5405_RS04275	COG3842	ATPase activity
H5405_RS04280	COG2356	endonuclease I
H5405_RS04285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5405_RS04290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5405_RS04295	COG2814	Major facilitator Superfamily
H5405_RS04315	COG2508	Transcriptional regulator
H5405_RS04330	COG1801	Protein of unknown function DUF72
H5405_RS04335	COG0730	response to heat
H5405_RS04340	COG0737	Belongs to the 5'-nucleotidase family
H5405_RS04350	COG0739	heme binding
H5405_RS04360	COG4470	Protein conserved in bacteria
H5405_RS04365	COG2445	Protein of unknown function DUF86
H5405_RS04370	COG0647	UMP catabolic process
H5405_RS04375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5405_RS04380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5405_RS04385	COG0460	homoserine dehydrogenase
H5405_RS04390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5405_RS04400	COG4946	Tricorn protease homolog
H5405_RS04400	COG1506	peptidase
H5405_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
H5405_RS04405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5405_RS04410	COG4837	Protein of unknown function (DUF1462)
H5405_RS04415	COG1252	NADH dehydrogenase
H5405_RS04425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5405_RS04435	COG0316	Belongs to the HesB IscA family
H5405_RS04440	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H5405_RS04465	COG1131	(ABC) transporter
H5405_RS04495	COG1252	NADH dehydrogenase
H5405_RS04510	COG3584	3D domain protein
H5405_RS04515	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H5405_RS04525	COG2056	Na+-H+ antiporter family
H5405_RS04530	COG1268	BioY protein
H5405_RS04535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5405_RS04540	COG2819	hydrolase of the alpha beta superfamily
H5405_RS04545	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS04550	COG1169	isochorismate synthase
H5405_RS04555	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5405_RS04560	COG3433	isochorismatase activity
H5405_RS04560	COG1535	isochorismatase
H5405_RS04565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS04570	COG3251	PFAM MbtH domain protein
H5405_RS04575	COG5634	Uncharacterized conserved protein (DUF2278)
H5405_RS04580	COG0686	Belongs to the AlaDH PNT family
H5405_RS04585	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H5405_RS04585	COG2508	Transcriptional regulator
H5405_RS04590	COG4842	Belongs to the WXG100 family
H5405_RS04595	COG5417	Belongs to the EsaB family
H5405_RS04600	COG4499	WXG100 protein secretion system (Wss), protein YukC
H5405_RS04605	COG0433	COG0433 Predicted ATPase
H5405_RS04605	COG1674	ftsk spoiiie
H5405_RS04610	COG1511	domain protein
H5405_RS04620	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS04625	COG1418	mRNA catabolic process
H5405_RS04635	COG0628	permease
H5405_RS04650	COG5506	Protein of unknown function (DUF1694)
H5405_RS04655	COG1335	isochorismatase
H5405_RS04660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5405_RS04665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5405_RS04680	COG0142	geranyltranstransferase activity
H5405_RS04690	COG4585	Histidine kinase
H5405_RS04695	COG2197	response regulator
H5405_RS04700	COG2050	protein possibly involved in aromatic compounds catabolism
H5405_RS04705	COG1320	monovalent cation:proton antiporter activity
H5405_RS04710	COG2212	antiporter activity
H5405_RS04715	COG1863	multisubunit Na H antiporter MnhE subunit
H5405_RS04720	COG0651	ATP synthesis coupled electron transport
H5405_RS04725	COG1006	Multisubunit Na H antiporter MnhC subunit
H5405_RS04730	COG2111	Na H antiporter
H5405_RS04735	COG2111	Na H antiporter
H5405_RS04735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5405_RS04745	COG1079	Belongs to the binding-protein-dependent transport system permease family
H5405_RS04750	COG4603	Belongs to the binding-protein-dependent transport system permease family
H5405_RS04755	COG3845	ABC transporter
H5405_RS04760	COG1744	ABC transporter substrate-binding protein PnrA-like
H5405_RS04765	COG4565	transcriptional regulatory protein
H5405_RS04770	COG3290	protein histidine kinase activity
H5405_RS04780	COG3011	Protein conserved in bacteria
H5405_RS04785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5405_RS04790	COG2814	Major facilitator Superfamily
H5405_RS04795	COG5018	Exonuclease
H5405_RS04805	COG2205	protein histidine kinase activity
H5405_RS04810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H5405_RS04820	COG2267	carboxylic ester hydrolase activity
H5405_RS04825	COG1522	sequence-specific DNA binding
H5405_RS04830	COG0436	Aminotransferase
H5405_RS04835	COG1098	S1 RNA binding domain
H5405_RS04840	COG2155	Conserved Protein
H5405_RS04845	COG1979	alcohol dehydrogenase
H5405_RS04850	COG1979	alcohol dehydrogenase
H5405_RS04855	COG1335	isochorismatase
H5405_RS04880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5405_RS04895	COG2738	Putative neutral zinc metallopeptidase
H5405_RS04900	COG1253	flavin adenine dinucleotide binding
H5405_RS04905	COG0366	Alpha amylase catalytic
H5405_RS04910	COG0432	Pfam Uncharacterised protein family UPF0047
H5405_RS04915	COG2070	2-Nitropropane dioxygenase
H5405_RS04930	COG0840	transmembrane signaling receptor activity
H5405_RS04935	COG0840	transmembrane signaling receptor activity
H5405_RS04940	COG0840	transmembrane signaling receptor activity
H5405_RS04945	COG0840	transmembrane signaling receptor activity
H5405_RS04950	COG0693	protein deglycase activity
H5405_RS04955	COG0673	inositol 2-dehydrogenase activity
H5405_RS04960	COG0628	permease
H5405_RS04985	COG1017	nitric oxide dioxygenase activity
H5405_RS04985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5405_RS04990	COG1705	Flagellar rod assembly protein muramidase FlgJ
H5405_RS04995	COG0569	domain protein
H5405_RS05005	COG1510	regulation of RNA biosynthetic process
H5405_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS05015	COG1454	alcohol dehydrogenase
H5405_RS05025	COG2318	DinB family
H5405_RS05030	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5405_RS05035	COG2268	Band 7 protein
H5405_RS05040	COG3859	Proton-coupled thiamine transporter YuaJ
H5405_RS05165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H5405_RS05170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5405_RS05175	COG1169	isochorismate synthase
H5405_RS05185	COG0596	Alpha beta hydrolase
H5405_RS05190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H5405_RS05200	COG4948	Mandelate Racemase Muconate Lactonizing
H5405_RS05210	COG1294	oxidase, subunit
H5405_RS05215	COG1271	oxidase subunit
H5405_RS05225	COG0288	reversible hydration of carbon dioxide
H5405_RS05250	COG0783	Belongs to the Dps family
H5405_RS05255	COG4824	toxin secretion phage lysis holin
H5405_RS05260	COG0494	nUDIX hydrolase
H5405_RS05265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5405_RS05270	COG1116	anion transmembrane transporter activity
H5405_RS05275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5405_RS05280	COG1506	peptidase
H5405_RS05300	COG0367	asparagine synthase
H5405_RS05305	COG1113	amino acid transport
H5405_RS05310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5405_RS05315	COG2267	carboxylic ester hydrolase activity
H5405_RS05335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H5405_RS05340	COG1242	4 iron, 4 sulfur cluster binding
H5405_RS05350	COG1725	Transcriptional regulator
H5405_RS05355	COG1131	(ABC) transporter
H5405_RS05375	COG1136	(ABC) transporter
H5405_RS05380	COG0577	efflux transmembrane transporter activity
H5405_RS05385	COG0745	RESPONSE REGULATOR receiver
H5405_RS05390	COG2205	protein histidine kinase activity
H5405_RS05395	COG1136	(ABC) transporter
H5405_RS05400	COG0577	efflux transmembrane transporter activity
H5405_RS05405	COG5522	Integral membrane protein (intg_mem_TP0381)
H5405_RS05410	COG2814	Major facilitator Superfamily
H5405_RS05415	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS05415	COG2202	Pas domain
H5405_RS05430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5405_RS05440	COG1486	melibiose metabolic process
H5405_RS05445	COG0395	ABC-type sugar transport system, permease component
H5405_RS05450	COG1175	transmembrane transport
H5405_RS05455	COG1653	transport
H5405_RS05460	COG1609	Transcriptional regulator
H5405_RS05470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5405_RS05475	COG2081	HI0933 family
H5405_RS05480	COG2244	polysaccharide biosynthetic process
H5405_RS05485	COG1187	pseudouridine synthase activity
H5405_RS05490	COG1349	DNA-binding transcription factor activity
H5405_RS05495	COG1131	(ABC) transporter
H5405_RS05500	COG4473	ABC transporter
H5405_RS05505	COG2252	PERMEase
H5405_RS05510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5405_RS05515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5405_RS05520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H5405_RS05530	COG1597	lipid kinase activity
H5405_RS05535	COG0510	thiamine kinase activity
H5405_RS05550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS05555	COG0281	malic enzyme
H5405_RS05560	COG5584	Small secreted protein
H5405_RS05565	COG1363	Peptidase, m42
H5405_RS05575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS05585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5405_RS05590	COG1674	ftsk spoiiie
H5405_RS05600	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H5405_RS05605	COG4980	gas vesicle protein
H5405_RS05610	COG3118	belongs to the thioredoxin family
H5405_RS05615	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H5405_RS05615	COG1605	Chorismate mutase
H5405_RS05620	COG1609	Transcriptional regulator
H5405_RS05625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5405_RS05630	COG1360	Flagellar Motor Protein
H5405_RS05635	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5405_RS05640	COG0517	IMP dehydrogenase activity
H5405_RS05645	COG0454	-acetyltransferase
H5405_RS05650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5405_RS05670	COG1378	Sugar-specific transcriptional regulator TrmB
H5405_RS05675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5405_RS05690	COG0693	protein deglycase activity
H5405_RS05700	COG1017	nitric oxide dioxygenase activity
H5405_RS05700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5405_RS05705	COG0582	viral genome integration into host DNA
H5405_RS05730	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS05740	COG2199	diguanylate cyclase activity
H5405_RS05740	COG2203	Gaf domain
H5405_RS05745	COG1956	GAF domain-containing protein
H5405_RS05750	COG1309	transcriptional regulator
H5405_RS05755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5405_RS05765	COG1114	Component of the transport system for branched-chain amino acids
H5405_RS05770	COG1104	cysteine desulfurase activity
H5405_RS05785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5405_RS05790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H5405_RS05795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5405_RS05800	COG0616	signal peptide processing
H5405_RS05805	COG1714	RDD family
H5405_RS05815	COG3874	Sporulation protein YtfJ
H5405_RS05820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H5405_RS05825	COG0827	DNA restriction-modification system
H5405_RS05835	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5405_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS05860	COG4109	DRTGG domain
H5405_RS05870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H5405_RS05890	COG0587	DNA-directed DNA polymerase activity
H5405_RS05895	COG0281	malic enzyme
H5405_RS05915	COG0469	pyruvate kinase activity
H5405_RS05920	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5405_RS05925	COG0628	permease
H5405_RS05940	COG0372	Belongs to the citrate synthase family
H5405_RS05945	COG0538	isocitrate dehydrogenase activity
H5405_RS05955	COG0745	RESPONSE REGULATOR receiver
H5405_RS05960	COG5002	protein histidine kinase activity
H5405_RS05965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5405_RS05965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5405_RS05970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5405_RS05975	COG1971	Probably functions as a manganese efflux pump
H5405_RS05980	COG0237	dephospho-CoA kinase activity
H5405_RS05985	COG0656	L-ascorbic acid biosynthetic process
H5405_RS05990	COG2814	Major facilitator Superfamily
H5405_RS05995	COG1733	regulation of RNA biosynthetic process
H5405_RS06000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5405_RS06015	COG3611	Membrane attachment protein
H5405_RS06020	COG1484	DNA-dependent DNA replication
H5405_RS06025	COG0398	Pfam SNARE associated Golgi protein
H5405_RS06040	COG1011	Hydrolase
H5405_RS06045	COG3275	phosphorelay sensor kinase activity
H5405_RS06050	COG3279	Response regulator of the LytR AlgR family
H5405_RS06055	COG1380	Effector of murein hydrolase LrgA
H5405_RS06060	COG1346	cytolysis
H5405_RS06065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5405_RS06080	COG3326	Membrane
H5405_RS06095	COG3507	Belongs to the glycosyl hydrolase 43 family
H5405_RS06100	COG2160	L-arabinose isomerase activity
H5405_RS06105	COG1069	ribulokinase activity
H5405_RS06110	COG0235	Class ii aldolase
H5405_RS06115	COG0647	UMP catabolic process
H5405_RS06125	COG1653	transport
H5405_RS06130	COG1175	transmembrane transport
H5405_RS06135	COG0395	ABC-type sugar transport system, permease component
H5405_RS06140	COG3534	alpha-L-arabinofuranosidase
H5405_RS06145	COG1966	Carbon starvation protein
H5405_RS06150	COG0247	lactate metabolic process
H5405_RS06155	COG0277	FAD linked oxidase domain protein
H5405_RS06160	COG3835	regulator
H5405_RS06170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5405_RS06175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5405_RS06180	COG0072	phenylalanine-tRNA ligase activity
H5405_RS06180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5405_RS06195	COG1286	toxin biosynthetic process
H5405_RS06200	COG1796	DNA polymerase
H5405_RS06200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5405_RS06210	COG3766	membrane
H5405_RS06220	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS06225	COG1309	transcriptional regulator
H5405_RS06230	COG1024	Enoyl-CoA hydratase
H5405_RS06235	COG2086	electron transfer activity
H5405_RS06240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H5405_RS06245	COG3534	alpha-L-arabinofuranosidase
H5405_RS06250	COG3118	belongs to the thioredoxin family
H5405_RS06260	COG0527	aspartate kinase activity
H5405_RS06265	COG1719	4-vinyl reductase, 4VR
H5405_RS06270	COG2009	succinate dehydrogenase
H5405_RS06275	COG1053	succinate dehydrogenase
H5405_RS06280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5405_RS06285	COG0824	Thioesterase
H5405_RS06290	COG2197	response regulator
H5405_RS06295	COG1846	Transcriptional regulator
H5405_RS06305	COG5401	PFAM Sporulation and spore germination
H5405_RS06315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5405_RS06320	COG0622	Phosphoesterase
H5405_RS06360	COG0028	Belongs to the TPP enzyme family
H5405_RS06365	COG0440	acetolactate synthase activity
H5405_RS06380	COG0473	3-isopropylmalate dehydrogenase activity
H5405_RS06395	COG0457	Tetratricopeptide repeat
H5405_RS06395	COG1477	protein flavinylation
H5405_RS06410	COG0470	DNA polymerase III
H5405_RS06410	COG1067	ATP-dependent peptidase activity
H5405_RS06415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5405_RS06435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5405_RS06445	COG1587	Uroporphyrinogen-III synthase
H5405_RS06450	COG0113	porphobilinogen synthase activity
H5405_RS06460	COG1388	LysM domain
H5405_RS06465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5405_RS06475	COG0525	valine-tRNA ligase activity
H5405_RS06480	COG0285	dihydrofolate synthase activity
H5405_RS06485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H5405_RS06505	COG1077	Cell shape determining protein MreB Mrl
H5405_RS06515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5405_RS06525	COG2894	cell division
H5405_RS06530	COG0739	heme binding
H5405_RS06535	COG1994	Peptidase M50
H5405_RS06545	COG2868	ribosomal protein
H5405_RS06550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5405_RS06555	COG3290	protein histidine kinase activity
H5405_RS06570	COG0077	Prephenate dehydratase
H5405_RS06575	COG1827	regulation of RNA biosynthetic process
H5405_RS06580	COG1104	cysteine desulfurase activity
H5405_RS06585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H5405_RS06590	COG0157	Belongs to the NadC ModD family
H5405_RS06600	COG1388	LysM domain
H5405_RS06645	COG1862	Preprotein translocase
H5405_RS06655	COG2323	membrane
H5405_RS06660	COG2244	polysaccharide biosynthetic process
H5405_RS06670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5405_RS06670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5405_RS06675	COG0490	domain, Protein
H5405_RS06680	COG5416	Lipopolysaccharide assembly protein A domain
H5405_RS06685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5405_RS06685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H5405_RS06695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5405_RS06705	COG4991	sh3 domain protein
H5405_RS06705	COG3103	Sh3 type 3 domain protein
H5405_RS06705	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS06730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5405_RS06735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5405_RS06740	COG1959	2 iron, 2 sulfur cluster binding
H5405_RS06745	COG1104	cysteine desulfurase activity
H5405_RS06755	COG0457	Tetratricopeptide repeat
H5405_RS06765	COG3881	PFAM PRC-barrel domain
H5405_RS06780	COG0765	amino acid transport
H5405_RS06785	COG0765	amino acid transport
H5405_RS06790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS06795	COG1126	abc transporter atp-binding protein
H5405_RS06800	COG0628	permease
H5405_RS06825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5405_RS06830	COG4122	O-methyltransferase activity
H5405_RS06835	COG0826	peptidase U32
H5405_RS06840	COG0826	peptidase U32
H5405_RS06855	COG0768	penicillin binding
H5405_RS06880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5405_RS06885	COG0626	cystathionine gamma-synthase activity
H5405_RS06895	COG2427	Protein of unknown function (DUF1641)
H5405_RS06900	COG3383	formate dehydrogenase (NAD+) activity
H5405_RS06905	COG5609	conserved protein (DUF2294)
H5405_RS06910	COG2116	formate transmembrane transporter activity
H5405_RS06925	COG2226	methyltransferase
H5405_RS06930	COG1309	transcriptional regulator
H5405_RS06935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5405_RS06935	COG2124	cytochrome p450
H5405_RS06940	COG2814	Major facilitator Superfamily
H5405_RS06945	COG0583	DNA-binding transcription factor activity
H5405_RS06950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5405_RS06960	COG3711	transcriptional antiterminator
H5405_RS06960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS06965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS06965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5405_RS06965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5405_RS06970	COG1482	cell wall glycoprotein biosynthetic process
H5405_RS06980	COG0561	phosphatase activity
H5405_RS06985	COG0561	phosphatase activity
H5405_RS06995	COG2318	DinB family
H5405_RS07000	COG0456	acetyltransferase
H5405_RS07015	COG0563	adenylate kinase activity
H5405_RS07020	COG2207	Transcriptional regulator
H5405_RS07020	COG3708	Transcriptional regulator
H5405_RS07050	COG0398	Pfam SNARE associated Golgi protein
H5405_RS07060	COG2755	lipolytic protein G-D-S-L family
H5405_RS07070	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H5405_RS07075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H5405_RS07080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5405_RS07085	COG1534	Rna-binding protein
H5405_RS07095	COG1713	HD superfamily hydrolase involved in NAD metabolism
H5405_RS07100	COG0799	negative regulation of ribosome biogenesis
H5405_RS07105	COG2226	methyltransferase
H5405_RS07110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5405_RS07115	COG1596	polysaccharide export
H5405_RS07115	COG1555	photosystem II stabilization
H5405_RS07120	COG2131	deaminase
H5405_RS07125	COG0658	competence protein
H5405_RS07125	COG2333	competence protein COMEC
H5405_RS07140	COG1466	dna polymerase III delta subunit
H5405_RS07155	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS07170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5405_RS07200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5405_RS07205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5405_RS07210	COG1283	sodium-dependent phosphate transmembrane transporter activity
H5405_RS07220	COG1610	YqeY-like protein
H5405_RS07225	COG1030	water channel activity
H5405_RS07230	COG4864	UPF0365 protein
H5405_RS07245	COG0561	phosphatase activity
H5405_RS07250	COG1702	phosphate starvation-inducible protein PhoH
H5405_RS07255	COG1480	7TM receptor with intracellular HD hydrolase
H5405_RS07265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5405_RS07270	COG0295	cytidine deaminase activity
H5405_RS07275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5405_RS07295	COG0751	glycine-tRNA ligase activity
H5405_RS07300	COG0517	IMP dehydrogenase activity
H5405_RS07315	COG0358	DNA primase activity
H5405_RS07320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5405_RS07325	COG2010	Cytochrome c
H5405_RS07330	COG2384	SAM-dependent methyltransferase
H5405_RS07335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5405_RS07350	COG0513	Belongs to the DEAD box helicase family
H5405_RS07365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS07370	COG0735	belongs to the Fur family
H5405_RS07375	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H5405_RS07380	COG4709	membrane
H5405_RS07390	COG1388	LysM domain
H5405_RS07395	COG5521	maltodextrose utilization protein MalA
H5405_RS07400	COG2839	Protein conserved in bacteria
H5405_RS07405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5405_RS07410	COG0477	Major facilitator Superfamily
H5405_RS07415	COG0768	penicillin binding
H5405_RS07420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5405_RS07425	COG0573	inorganic phosphate transmembrane transporter activity
H5405_RS07430	COG0581	inorganic phosphate transmembrane transporter activity
H5405_RS07435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5405_RS07440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5405_RS07445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5405_RS07460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5405_RS07470	COG1757	Na H antiporter
H5405_RS07475	COG4483	Protein conserved in bacteria
H5405_RS07480	COG1940	carbohydrate kinase activity
H5405_RS07485	COG2866	Carboxypeptidase
H5405_RS07495	COG0011	TIGRFAM Protein of
H5405_RS07505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS07515	COG1393	Belongs to the ArsC family
H5405_RS07525	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS07530	COG1253	flavin adenine dinucleotide binding
H5405_RS07535	COG0598	Magnesium transport protein CorA
H5405_RS07540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5405_RS07545	COG1459	type II secretion system
H5405_RS07550	COG4537	Required for transformation and DNA binding
H5405_RS07555	COG4970	Tfp pilus assembly protein FimT
H5405_RS07565	COG4940	Competence protein ComGF
H5405_RS07590	COG0681	Belongs to the peptidase S26 family
H5405_RS07600	COG1396	sequence-specific DNA binding
H5405_RS07615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5405_RS07635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5405_RS07650	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5405_RS07660	COG3872	metal-dependent enzyme
H5405_RS07670	COG0006	proline dipeptidase activity
H5405_RS07685	COG3854	ATPases associated with a variety of cellular activities
H5405_RS07725	COG0511	ligase activity, forming carbon-carbon bonds
H5405_RS07730	COG0439	Biotin carboxylase
H5405_RS07735	COG1302	Protein conserved in bacteria
H5405_RS07750	COG1570	exodeoxyribonuclease VII activity
H5405_RS07760	COG0142	geranyltranstransferase activity
H5405_RS07770	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H5405_RS07780	COG0497	DNA recombination
H5405_RS07785	COG0750	zinc metalloprotease
H5405_RS07790	COG0745	RESPONSE REGULATOR receiver
H5405_RS07795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5405_RS07810	COG1902	pentaerythritol trinitrate reductase activity
H5405_RS07835	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS07840	COG0584	glycerophosphoryl diester phosphodiesterase
H5405_RS07845	COG0183	Belongs to the thiolase family
H5405_RS07850	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5405_RS07855	COG1960	acyl-CoA dehydrogenase activity
H5405_RS07860	COG0372	Belongs to the citrate synthase family
H5405_RS07865	COG2079	MmgE PrpD family protein
H5405_RS07870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H5405_RS07880	COG3290	protein histidine kinase activity
H5405_RS07880	COG3829	transcription factor binding
H5405_RS07885	COG0280	phosphate acetyltransferase
H5405_RS07890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5405_RS07895	COG3426	butyrate kinase activity
H5405_RS07900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5405_RS07905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5405_RS07910	COG0022	dehydrogenase e1 component
H5405_RS07915	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5405_RS07920	COG1597	lipid kinase activity
H5405_RS07930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS07935	COG0765	amino acid transport
H5405_RS07940	COG1126	abc transporter atp-binding protein
H5405_RS07945	COG4129	membrane
H5405_RS07950	COG1376	ErfK ybiS ycfS ynhG family protein
H5405_RS07960	COG0346	lactoylglutathione lyase activity
H5405_RS07965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5405_RS07970	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5405_RS07975	COG0706	membrane insertase activity
H5405_RS07990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H5405_RS07995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5405_RS08010	COG0596	Alpha beta hydrolase
H5405_RS08030	COG0250	Participates in transcription elongation, termination and antitermination
H5405_RS08035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5405_RS08035	COG2070	2-Nitropropane dioxygenase
H5405_RS08050	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS08060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS08060	COG3321	synthase
H5405_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08065	COG3321	synthase
H5405_RS08065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS08065	COG0300	oxidoreductase activity
H5405_RS08075	COG3321	synthase
H5405_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08075	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS08075	COG0300	oxidoreductase activity
H5405_RS08080	COG0300	oxidoreductase activity
H5405_RS08080	COG3321	synthase
H5405_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS08085	COG3321	synthase
H5405_RS08085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS08090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS08090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS08090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS08090	COG3321	synthase
H5405_RS08095	COG2124	cytochrome p450
H5405_RS08100	COG3425	synthase
H5405_RS08105	COG1024	Enoyl-CoA hydratase
H5405_RS08110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5405_RS08115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS08120	COG0300	oxidoreductase activity
H5405_RS08125	COG3048	D-serine ammonia-lyase activity
H5405_RS08135	COG0346	lactoylglutathione lyase activity
H5405_RS08160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5405_RS08165	COG0456	acetyltransferase
H5405_RS08170	COG2329	Antibiotic biosynthesis monooxygenase
H5405_RS08175	COG0456	acetyltransferase
H5405_RS08175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H5405_RS08180	COG4918	Iron-sulphur cluster biosynthesis
H5405_RS08190	COG1073	alpha beta
H5405_RS08200	COG0667	Aldo Keto reductase
H5405_RS08210	COG0494	nUDIX hydrolase
H5405_RS08215	COG1379	DNA repair
H5405_RS08220	COG1396	sequence-specific DNA binding
H5405_RS08225	COG0252	asparaginase activity
H5405_RS08230	COG1027	Aspartate ammonia-lyase
H5405_RS08235	COG1757	Na H antiporter
H5405_RS08240	COG0281	malic enzyme
H5405_RS08255	COG1300	Membrane
H5405_RS08260	COG0735	belongs to the Fur family
H5405_RS08270	COG4974	Belongs to the 'phage' integrase family
H5405_RS08275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H5405_RS08280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H5405_RS08285	COG1686	Belongs to the peptidase S11 family
H5405_RS08290	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS08300	COG1191	sigma factor activity
H5405_RS08320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5405_RS08335	COG0697	spore germination
H5405_RS08340	COG0019	diaminopimelate decarboxylase activity
H5405_RS08345	COG4086	secreted protein
H5405_RS08350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5405_RS08360	COG0681	Belongs to the peptidase S26 family
H5405_RS08370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5405_RS08370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5405_RS08375	COG0307	riboflavin synthase, alpha
H5405_RS08390	COG0456	acetyltransferase
H5405_RS08395	COG1547	Domain of unknown function (DUF309)
H5405_RS08420	COG1686	Belongs to the peptidase S11 family
H5405_RS08425	COG2715	membrane protein required for spore maturation
H5405_RS08430	COG0700	Nucleoside recognition
H5405_RS08435	COG1187	pseudouridine synthase activity
H5405_RS08440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS08445	COG1333	cytochrome c biogenesis protein
H5405_RS08450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5405_RS08455	COG0745	RESPONSE REGULATOR receiver
H5405_RS08460	COG5002	protein histidine kinase activity
H5405_RS08465	COG1595	DNA-templated transcription, initiation
H5405_RS08475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5405_RS08480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H5405_RS08485	COG1141	Ferredoxin
H5405_RS08490	COG4955	Helix-turn-helix domain
H5405_RS08495	COG0514	ATP-dependent DNA helicase (RecQ)
H5405_RS08500	COG1266	CAAX protease self-immunity
H5405_RS08505	COG1388	LysM domain
H5405_RS08515	COG1408	metallophosphoesterase
H5405_RS08520	COG4862	establishment of competence for transformation
H5405_RS08525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5405_RS08530	COG0492	ferredoxin-NADP+ reductase activity
H5405_RS08535	COG2339	peptidase activity
H5405_RS08540	COG3409	Peptidoglycan-binding domain 1 protein
H5405_RS08540	COG3773	Cell wall hydrolase
H5405_RS08545	COG2959	enzyme of heme biosynthesis
H5405_RS08550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H5405_RS08565	COG0539	negative regulation of cytoplasmic translation
H5405_RS08605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H5405_RS08610	COG0776	regulation of translation
H5405_RS08625	COG0142	geranyltranstransferase activity
H5405_RS08635	COG0142	geranyltranstransferase activity
H5405_RS08640	COG0105	UTP biosynthetic process
H5405_RS08645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5405_RS08660	COG4401	Chorismate mutase type I
H5405_RS08665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5405_RS08700	COG0287	Prephenate dehydrogenase
H5405_RS08710	COG0457	Tetratricopeptide repeat
H5405_RS08725	COG0723	plastoquinol--plastocyanin reductase activity
H5405_RS08730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5405_RS08735	COG2010	Cytochrome c
H5405_RS08735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5405_RS08740	COG4347	Protein of unknown function (DUF1405)
H5405_RS08750	COG2140	Oxalate decarboxylase
H5405_RS08755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS08760	COG1694	Mazg nucleotide pyrophosphohydrolase
H5405_RS08775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H5405_RS08780	COG0438	transferase activity, transferring glycosyl groups
H5405_RS08810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5405_RS08810	COG1199	ATP-dependent helicase activity
H5405_RS08820	COG5353	protein conserved in bacteria
H5405_RS08825	COG0436	Aminotransferase
H5405_RS08835	COG3935	DnaD domain protein
H5405_RS08840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5405_RS08850	COG4499	WXG100 protein secretion system (Wss), protein YukC
H5405_RS08850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5405_RS08890	COG0071	Belongs to the small heat shock protein (HSP20) family
H5405_RS08895	COG2190	(PTS) system
H5405_RS08900	COG1111	helicase
H5405_RS08900	COG1205	dead DEAH box helicase
H5405_RS08905	COG3359	exonuclease
H5405_RS08935	COG0116	Belongs to the methyltransferase superfamily
H5405_RS08950	COG1199	ATP-dependent helicase activity
H5405_RS08955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H5405_RS08965	COG2233	PERMEase
H5405_RS08975	COG1335	isochorismatase
H5405_RS08980	COG2323	membrane
H5405_RS09000	COG3424	synthase
H5405_RS09005	COG1755	Isoprenylcysteine carboxyl methyltransferase
H5405_RS09015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H5405_RS09030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5405_RS09040	COG0328	RNA-DNA hybrid ribonuclease activity
H5405_RS09045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H5405_RS09050	COG0328	RNA-DNA hybrid ribonuclease activity
H5405_RS09070	COG1278	Cold shock
H5405_RS09080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5405_RS09090	COG0386	Belongs to the glutathione peroxidase family
H5405_RS09095	COG1418	mRNA catabolic process
H5405_RS09100	COG1413	lyase activity
H5405_RS09115	COG2521	methyltransferase
H5405_RS09115	COG2136	Putative SAM-dependent methyltransferase
H5405_RS09130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5405_RS09135	COG0204	Acyl-transferase
H5405_RS09140	COG1272	protein, Hemolysin III
H5405_RS09145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5405_RS09150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5405_RS09160	COG1999	signal sequence binding
H5405_RS09165	COG2755	lipolytic protein G-D-S-L family
H5405_RS09170	COG4698	Protein conserved in bacteria
H5405_RS09175	COG1846	Transcriptional regulator
H5405_RS09195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5405_RS09200	COG1525	nuclease
H5405_RS09210	COG5444	nuclease activity
H5405_RS09240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5405_RS09250	COG0457	Tetratricopeptide repeat
H5405_RS09255	COG1388	LysM domain
H5405_RS09275	COG3331	DNA recombination
H5405_RS09285	COG1086	Polysaccharide biosynthesis protein
H5405_RS09295	COG4641	Protein conserved in bacteria
H5405_RS09310	COG0463	Glycosyl transferase, family 2
H5405_RS09315	COG0456	acetyltransferase
H5405_RS09325	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5405_RS09330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5405_RS09335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5405_RS09340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5405_RS09345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5405_RS09350	COG0456	acetyltransferase
H5405_RS09355	COG1509	lysine 2,3-aminomutase activity
H5405_RS09385	COG0671	phosphoesterase, PA-phosphatase related
H5405_RS09405	COG1876	peptidase activity
H5405_RS09415	COG2226	methyltransferase
H5405_RS09425	COG2188	Transcriptional regulator
H5405_RS09430	COG2723	6-phospho-beta-galactosidase activity
H5405_RS09440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5405_RS09450	COG0346	lactoylglutathione lyase activity
H5405_RS09455	COG0400	carboxylic ester hydrolase activity
H5405_RS09460	COG0778	Nitroreductase
H5405_RS09465	COG1733	regulation of RNA biosynthetic process
H5405_RS09475	COG1942	4-Oxalocrotonate Tautomerase
H5405_RS09490	COG2962	Rard protein
H5405_RS09500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H5405_RS09505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H5405_RS09510	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS09515	COG0534	Mate efflux family protein
H5405_RS09520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H5405_RS09525	COG1819	glycosyl
H5405_RS09530	COG1388	LysM domain
H5405_RS09530	COG0791	NLP P60 protein
H5405_RS09535	COG2032	superoxide dismutase activity
H5405_RS09540	COG0714	Associated with various cellular activities
H5405_RS09545	COG4548	von Willebrand factor, type A
H5405_RS09555	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5405_RS09560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS09565	COG0385	Bile acid
H5405_RS09570	COG0733	neurotransmitter:sodium symporter activity
H5405_RS09575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5405_RS09580	COG1657	PFAM Prenyltransferase squalene oxidase
H5405_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS09615	COG0071	Belongs to the small heat shock protein (HSP20) family
H5405_RS09630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5405_RS09635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5405_RS09645	COG0514	ATP-dependent DNA helicase (RecQ)
H5405_RS09650	COG1388	LysM domain
H5405_RS09650	COG3584	3D domain protein
H5405_RS09660	COG1619	proteins homologs of microcin C7 resistance protein MccF
H5405_RS09675	COG2322	membrane
H5405_RS09680	COG0741	lytic transglycosylase activity
H5405_RS09685	COG0640	Transcriptional regulator
H5405_RS09695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS09700	COG1309	transcriptional regulator
H5405_RS09705	COG0662	Cupin 2, conserved barrel domain protein
H5405_RS09705	COG2207	Transcriptional regulator
H5405_RS09710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5405_RS09715	COG5444	nuclease activity
H5405_RS09745	COG0243	molybdopterin cofactor binding
H5405_RS09750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5405_RS09755	COG1070	Carbohydrate kinase
H5405_RS09760	COG2814	Major facilitator Superfamily
H5405_RS09770	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H5405_RS09775	COG0300	oxidoreductase activity
H5405_RS09790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5405_RS09795	COG0583	DNA-binding transcription factor activity
H5405_RS09800	COG0067	glutamate synthase
H5405_RS09800	COG0069	glutamate synthase activity
H5405_RS09800	COG0070	glutamate synthase
H5405_RS09805	COG0493	'glutamate synthase
H5405_RS09820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5405_RS09825	COG0640	Transcriptional regulator
H5405_RS09830	COG2814	Major facilitator Superfamily
H5405_RS09835	COG0405	Gamma-glutamyltransferase
H5405_RS09840	COG0166	Belongs to the GPI family
H5405_RS09845	COG0582	viral genome integration into host DNA
H5405_RS09860	COG0534	Mate efflux family protein
H5405_RS09865	COG2017	converts alpha-aldose to the beta-anomer
H5405_RS09870	COG2027	D-alanyl-D-alanine carboxypeptidase
H5405_RS09875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS09880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS09885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS09895	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5405_RS09905	COG1649	PFAM Uncharacterised BCR, COG1649
H5405_RS09910	COG1960	acyl-CoA dehydrogenase activity
H5405_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS09920	COG0439	Biotin carboxylase
H5405_RS09925	COG0511	ligase activity, forming carbon-carbon bonds
H5405_RS09930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5405_RS09935	COG1024	Enoyl-CoA hydratase
H5405_RS09940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5405_RS09945	COG0586	Pfam SNARE associated Golgi protein
H5405_RS09950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5405_RS09955	COG2246	polysaccharide biosynthetic process
H5405_RS09965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5405_RS09990	COG2610	gluconate transmembrane transporter activity
H5405_RS09995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5405_RS10000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5405_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10030	COG3507	Belongs to the glycosyl hydrolase 43 family
H5405_RS10040	COG0745	RESPONSE REGULATOR receiver
H5405_RS10045	COG2205	protein histidine kinase activity
H5405_RS10095	COG2271	Major facilitator Superfamily
H5405_RS10100	COG1609	Transcriptional regulator
H5405_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10110	COG1312	Catalyzes the dehydration of D-mannonate
H5405_RS10115	COG0800	Aldolase
H5405_RS10120	COG1063	alcohol dehydrogenase
H5405_RS10130	COG1115	amino acid carrier protein
H5405_RS10140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H5405_RS10145	COG0187	DNA topoisomerase II activity
H5405_RS10150	COG1832	CoA-binding protein
H5405_RS10160	COG4841	protein insertion into membrane
H5405_RS10170	COG0824	Thioesterase
H5405_RS10190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS10195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5405_RS10210	COG0071	Belongs to the small heat shock protein (HSP20) family
H5405_RS10220	COG4846	Membrane protein involved in cytochrome C biogenesis
H5405_RS10225	COG2201	protein-glutamate methylesterase activity
H5405_RS10230	COG0785	Cytochrome C biogenesis protein
H5405_RS10250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5405_RS10260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5405_RS10295	COG4195	phage-related replication protein
H5405_RS10300	COG0756	dUTP diphosphatase activity
H5405_RS10305	COG5434	Belongs to the glycosyl hydrolase 28 family
H5405_RS10325	COG3397	chitin binding
H5405_RS10355	COG0456	acetyltransferase
H5405_RS10375	COG1064	alcohol dehydrogenase
H5405_RS10380	COG2318	DinB family
H5405_RS10405	COG3848	Pyruvate phosphate dikinase
H5405_RS10405	COG0574	Belongs to the PEP-utilizing enzyme family
H5405_RS10410	COG1070	Carbohydrate kinase
H5405_RS10425	COG3507	Belongs to the glycosyl hydrolase 43 family
H5405_RS10430	COG2211	Major facilitator Superfamily
H5405_RS10450	COG0174	glutamine synthetase
H5405_RS10455	COG0789	Transcriptional regulator
H5405_RS10460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H5405_RS10465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5405_RS10470	COG0464	growth
H5405_RS10475	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS10480	COG4112	unkown
H5405_RS10485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5405_RS10490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5405_RS10530	COG2076	Multidrug Resistance protein
H5405_RS10540	COG1764	response to oxidative stress
H5405_RS10545	COG4195	phage-related replication protein
H5405_RS10555	COG1404	Belongs to the peptidase S8 family
H5405_RS10565	COG3619	membrane
H5405_RS10570	COG3209	COG3209 Rhs family protein
H5405_RS10575	COG2124	cytochrome p450
H5405_RS10580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5405_RS10580	COG3321	synthase
H5405_RS10580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS10580	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5405_RS10585	COG4221	oxidoreductase activity
H5405_RS10585	COG3321	synthase
H5405_RS10585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10590	COG3321	synthase
H5405_RS10590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS10590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS10590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS10590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS10590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS10590	COG3321	synthase
H5405_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS10595	COG4221	oxidoreductase activity
H5405_RS10595	COG3321	synthase
H5405_RS10595	COG0300	oxidoreductase activity
H5405_RS10600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS10600	COG0300	oxidoreductase activity
H5405_RS10600	COG3321	synthase
H5405_RS10600	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS10605	COG1024	Enoyl-CoA hydratase
H5405_RS10610	COG1024	Enoyl-CoA hydratase
H5405_RS10615	COG3425	synthase
H5405_RS10620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS10665	COG4550	Control of competence regulator ComK, YlbF/YmcA
H5405_RS10685	COG2359	stage V sporulation protein S
H5405_RS10690	COG1692	metallophosphoesterase
H5405_RS10700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5405_RS10715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5405_RS10720	COG1426	Protein conserved in bacteria
H5405_RS10735	COG0300	oxidoreductase activity
H5405_RS10740	COG0612	Peptidase, M16
H5405_RS10745	COG0612	Peptidase, M16
H5405_RS10750	COG1033	growth of symbiont in host cell
H5405_RS10750	COG2409	Drug exporters of the RND superfamily
H5405_RS10755	COG1846	Transcriptional regulator
H5405_RS10760	COG2814	Major facilitator Superfamily
H5405_RS10765	COG2188	Transcriptional regulator
H5405_RS10780	COG0740	serine-type endopeptidase activity
H5405_RS10785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H5405_RS10795	COG0527	aspartate kinase activity
H5405_RS10800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5405_RS10805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5405_RS10810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5405_RS10815	COG1873	PFAM PRC-barrel domain
H5405_RS10820	COG0612	Peptidase, M16
H5405_RS10825	COG0726	polysaccharide deacetylase
H5405_RS10840	COG0196	riboflavin kinase activity
H5405_RS10855	COG1550	Protein conserved in bacteria
H5405_RS10865	COG1358	cellular component organization or biogenesis
H5405_RS10870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H5405_RS10875	COG0195	Participates in both transcription termination and antitermination
H5405_RS10885	COG2176	DNA-directed DNA polymerase activity
H5405_RS10905	COG4589	Belongs to the CDS family
H5405_RS10910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5405_RS10940	COG1191	sigma factor activity
H5405_RS10950	COG1776	CheC inhibitor of MCP methylation
H5405_RS10955	COG0835	chemotaxis
H5405_RS10960	COG2198	Histidine kinase
H5405_RS10960	COG0643	Histidine kinase
H5405_RS10965	COG2201	protein-glutamate methylesterase activity
H5405_RS10970	COG0455	bacterial-type flagellum organization
H5405_RS10975	COG1419	protein localization to endoplasmic reticulum
H5405_RS10980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5405_RS10985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5405_RS10990	COG1684	flagellar biosynthetic protein fliR
H5405_RS10995	COG1987	bacterial-type flagellum assembly
H5405_RS11000	COG1338	Plays a role in the flagellum-specific transport system
H5405_RS11005	COG3190	flagellar
H5405_RS11010	COG2201	protein-glutamate methylesterase activity
H5405_RS11015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5405_RS11015	COG1776	CheC inhibitor of MCP methylation
H5405_RS11020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5405_RS11025	COG1580	Controls the rotational direction of flagella during chemotaxis
H5405_RS11030	COG1582	Flagellar protein (FlbD)
H5405_RS11035	COG4786	Flagellar basal body rod
H5405_RS11040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5405_RS11045	COG3144	bacterial-type flagellum assembly
H5405_RS11050	COG3334	PFAM MgtE intracellular
H5405_RS11055	COG2882	bacterial-type flagellum organization
H5405_RS11060	COG1157	protein secretion by the type III secretion system
H5405_RS11065	COG1317	bacterial-type flagellum organization
H5405_RS11070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5405_RS11075	COG1766	The M ring may be actively involved in energy transduction
H5405_RS11080	COG1677	Flagellar hook-basal body complex protein FliE
H5405_RS11085	COG1558	bacterial-type flagellum-dependent cell motility
H5405_RS11090	COG1815	bacterial-type flagellum-dependent cell motility
H5405_RS11110	COG4974	Belongs to the 'phage' integrase family
H5405_RS11120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5405_RS11125	COG0758	DNA mediated transformation
H5405_RS11130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5405_RS11140	COG2257	FlhB HrpN YscU SpaS Family
H5405_RS11155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H5405_RS11180	COG1837	Belongs to the UPF0109 family
H5405_RS11190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5405_RS11205	COG0552	protein localization to endoplasmic reticulum
H5405_RS11210	COG1196	nuclear chromosome segregation
H5405_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS11230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5405_RS11245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5405_RS11250	COG1760	l-serine dehydratase
H5405_RS11255	COG1760	l-serine dehydratase
H5405_RS11260	COG1461	Dihydroxyacetone kinase
H5405_RS11265	COG1302	Protein conserved in bacteria
H5405_RS11280	COG1564	THIamine pyrophosphokinase
H5405_RS11285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5405_RS11295	COG0515	serine threonine protein kinase
H5405_RS11295	COG2815	serine threonine protein kinase
H5405_RS11300	COG0631	protein serine/threonine phosphatase activity
H5405_RS11310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5405_RS11310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5405_RS11320	COG0242	peptide deformylase activity
H5405_RS11325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5405_RS11330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5405_RS11340	COG0194	GDP metabolic process
H5405_RS11350	COG1561	YicC-like family, N-terminal region
H5405_RS11355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H5405_RS11370	COG1648	precorrin-2 dehydrogenase activity
H5405_RS11375	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H5405_RS11380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5405_RS11395	COG0306	phosphate transporter
H5405_RS11405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5405_RS11410	COG0284	orotidine-5'-phosphate decarboxylase activity
H5405_RS11425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5405_RS11430	COG0505	Belongs to the CarA family
H5405_RS11435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5405_RS11445	COG2233	PERMEase
H5405_RS11455	COG0564	pseudouridine synthase activity
H5405_RS11465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5405_RS11470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5405_RS11475	COG3599	regulation of cell shape
H5405_RS11480	COG2302	S4 RNA-binding domain
H5405_RS11485	COG0762	integral membrane protein
H5405_RS11495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5405_RS11500	COG1496	oxidoreductase activity
H5405_RS11505	COG1873	PFAM PRC-barrel domain
H5405_RS11510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5405_RS11515	COG1119	ATPase activity
H5405_RS11520	COG1191	sigma factor activity
H5405_RS11525	COG1191	sigma factor activity
H5405_RS11535	COG4412	M6 family metalloprotease domain protein
H5405_RS11535	COG1404	Belongs to the peptidase S8 family
H5405_RS11540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5405_RS11545	COG0849	cell division
H5405_RS11550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5405_RS11565	COG0772	Belongs to the SEDS family
H5405_RS11585	COG0768	penicillin binding
H5405_RS11590	COG0768	penicillin binding
H5405_RS11595	COG4839	cell division protein FtsL
H5405_RS11615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H5405_RS11635	COG1399	metal-binding, possibly nucleic acid-binding protein
H5405_RS11645	COG3480	Lon protease (S16) C-terminal proteolytic domain
H5405_RS11650	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5405_RS11655	COG3314	Sporulation integral membrane protein YlbJ
H5405_RS11665	COG0742	ribosomal rna small subunit methyltransferase
H5405_RS11680	COG3679	Belongs to the UPF0342 family
H5405_RS11695	COG2340	Cysteine-rich secretory protein family
H5405_RS11700	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H5405_RS11710	COG3336	cytochrome c oxidase
H5405_RS11715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5405_RS11720	COG1845	cytochrome c oxidase, subunit III
H5405_RS11725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5405_RS11730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5405_RS11730	COG2010	Cytochrome c
H5405_RS11745	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H5405_RS11750	COG0772	Belongs to the SEDS family
H5405_RS11760	COG2066	Belongs to the glutaminase family
H5405_RS11765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5405_RS11770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H5405_RS11780	COG4896	Protein conserved in bacteria
H5405_RS11790	COG1217	gtp-binding protein TYPA
H5405_RS11810	COG1595	DNA-templated transcription, initiation
H5405_RS11825	COG3227	Zinc metalloprotease (Elastase)
H5405_RS11835	COG0483	inositol monophosphate 1-phosphatase activity
H5405_RS11855	COG1982	Orn Lys Arg decarboxylase major
H5405_RS11870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS11875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5405_RS11880	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5405_RS11885	COG0022	dehydrogenase e1 component
H5405_RS11890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5405_RS11895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5405_RS11900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS11900	COG3321	synthase
H5405_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS11900	COG4221	oxidoreductase activity
H5405_RS11905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS11905	COG0300	oxidoreductase activity
H5405_RS11905	COG4221	oxidoreductase activity
H5405_RS11905	COG3321	synthase
H5405_RS11910	COG0300	oxidoreductase activity
H5405_RS11910	COG3321	synthase
H5405_RS11910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS11910	COG4221	oxidoreductase activity
H5405_RS11915	COG4221	oxidoreductase activity
H5405_RS11915	COG0300	oxidoreductase activity
H5405_RS11915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS11915	COG3321	synthase
H5405_RS11920	COG4221	oxidoreductase activity
H5405_RS11920	COG3321	synthase
H5405_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS11920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS11925	COG0300	oxidoreductase activity
H5405_RS11925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS11925	COG3321	synthase
H5405_RS11925	COG4221	oxidoreductase activity
H5405_RS11930	COG4221	oxidoreductase activity
H5405_RS11930	COG3321	synthase
H5405_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS11930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS11935	COG2070	2-Nitropropane dioxygenase
H5405_RS11935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5405_RS11940	COG0497	DNA recombination
H5405_RS11950	COG0242	peptide deformylase activity
H5405_RS11955	COG0561	phosphatase activity
H5405_RS11965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H5405_RS11975	COG0569	domain protein
H5405_RS11980	COG2105	PFAM AIG2 family protein
H5405_RS11980	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H5405_RS11985	COG3852	Histidine kinase
H5405_RS11990	COG2002	toxin-antitoxin pair type II binding
H5405_RS11995	COG1077	Cell shape determining protein MreB Mrl
H5405_RS12005	COG2309	aminopeptidase activity
H5405_RS12010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H5405_RS12015	COG0488	(ABC) transporter
H5405_RS12025	COG0681	Belongs to the peptidase S26 family
H5405_RS12030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5405_RS12030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5405_RS12030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS12035	COG1105	Belongs to the carbohydrate kinase PfkB family
H5405_RS12040	COG1349	DNA-binding transcription factor activity
H5405_RS12045	COG0577	efflux transmembrane transporter activity
H5405_RS12050	COG1136	(ABC) transporter
H5405_RS12055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5405_RS12065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5405_RS12070	COG0314	molybdopterin synthase activity
H5405_RS12075	COG1763	Mo-molybdopterin cofactor biosynthetic process
H5405_RS12080	COG0303	'Molybdopterin
H5405_RS12085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5405_RS12105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS12110	COG0668	transmembrane transport
H5405_RS12130	COG0716	FMN binding
H5405_RS12140	COG0716	FMN binding
H5405_RS12145	COG0583	DNA-binding transcription factor activity
H5405_RS12150	COG0517	IMP dehydrogenase activity
H5405_RS12160	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H5405_RS12165	COG4703	Protein of unknown function (DUF1797)
H5405_RS12170	COG2200	EAL domain
H5405_RS12180	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS12185	COG1408	metallophosphoesterase
H5405_RS12190	COG1376	ErfK ybiS ycfS ynhG family protein
H5405_RS12195	COG2814	Major facilitator Superfamily
H5405_RS12205	COG0835	chemotaxis
H5405_RS12205	COG0784	Response regulator, receiver
H5405_RS12215	COG0436	Aminotransferase
H5405_RS12220	COG4191	Histidine kinase
H5405_RS12225	COG0768	penicillin binding
H5405_RS12230	COG2340	Cysteine-rich secretory protein family
H5405_RS12235	COG2084	Dehydrogenase
H5405_RS12240	COG0840	transmembrane signaling receptor activity
H5405_RS12245	COG1533	DNA photolyase activity
H5405_RS12255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5405_RS12260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS12265	COG1263	PTS System
H5405_RS12265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS12265	COG2190	(PTS) system
H5405_RS12270	COG3711	transcriptional antiterminator
H5405_RS12275	COG1609	Transcriptional regulator
H5405_RS12280	COG0006	proline dipeptidase activity
H5405_RS12285	COG2217	Heavy metal translocating P-type atpase
H5405_RS12290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS12295	COG2244	polysaccharide biosynthetic process
H5405_RS12300	COG3773	Cell wall hydrolase
H5405_RS12310	COG4873	Protein conserved in bacteria
H5405_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS12330	COG1733	regulation of RNA biosynthetic process
H5405_RS12345	COG0602	queuosine metabolic process
H5405_RS12350	COG0720	synthase
H5405_RS12365	COG3949	Membrane
H5405_RS12370	COG0542	response to heat
H5405_RS12375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5405_RS12380	COG1360	Flagellar Motor Protein
H5405_RS12385	COG1846	Transcriptional regulator
H5405_RS12390	COG3852	Histidine kinase
H5405_RS12420	COG0436	Aminotransferase
H5405_RS12425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5405_RS12440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5405_RS12445	COG5002	protein histidine kinase activity
H5405_RS12450	COG3594	Acyltransferase
H5405_RS12460	COG2323	membrane
H5405_RS12465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5405_RS12490	COG1191	sigma factor activity
H5405_RS12495	COG0861	Integral membrane protein TerC family
H5405_RS12500	COG0586	Pfam SNARE associated Golgi protein
H5405_RS12505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H5405_RS12510	COG3285	dna ligase
H5405_RS12510	COG1793	dna ligase
H5405_RS12515	COG0726	polysaccharide deacetylase
H5405_RS12520	COG1846	Transcriptional regulator
H5405_RS12535	COG0789	Transcriptional regulator
H5405_RS12540	COG2239	Acts as a magnesium transporter
H5405_RS12550	COG3858	chitin binding
H5405_RS12550	COG1388	LysM domain
H5405_RS12555	COG4721	ABC-type cobalt transport system, permease component
H5405_RS12560	COG1122	ATPase activity
H5405_RS12565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H5405_RS12570	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS12575	COG1404	Belongs to the peptidase S8 family
H5405_RS12585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5405_RS12590	COG2814	Major facilitator Superfamily
H5405_RS12600	COG0463	Glycosyl transferase, family 2
H5405_RS12600	COG0457	Tetratricopeptide repeat
H5405_RS12615	COG1764	response to oxidative stress
H5405_RS12620	COG1846	Transcriptional regulator
H5405_RS12625	COG1764	response to oxidative stress
H5405_RS12635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5405_RS12640	COG0788	formyltetrahydrofolate deformylase activity
H5405_RS12645	COG2076	Multidrug Resistance protein
H5405_RS12650	COG2076	Multidrug Resistance protein
H5405_RS12655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5405_RS12660	COG1607	acyl-coa hydrolase
H5405_RS12665	COG1834	amidinotransferase
H5405_RS12670	COG2706	6-phosphogluconolactonase activity
H5405_RS12675	COG4608	Belongs to the ABC transporter superfamily
H5405_RS12680	COG0791	NLP P60 protein
H5405_RS12685	COG4948	Mandelate Racemase Muconate Lactonizing
H5405_RS12690	COG1619	proteins homologs of microcin C7 resistance protein MccF
H5405_RS12695	COG4166	transmembrane transport
H5405_RS12700	COG0444	Belongs to the ABC transporter superfamily
H5405_RS12705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5405_RS12710	COG0601	transmembrane transport
H5405_RS12715	COG2362	D-Aminopeptidase
H5405_RS12720	COG0477	Major facilitator Superfamily
H5405_RS12725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5405_RS12735	COG0463	Glycosyl transferase, family 2
H5405_RS12740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5405_RS12745	COG0346	lactoylglutathione lyase activity
H5405_RS12750	COG0531	amino acid
H5405_RS12755	COG1392	Phosphate transport regulator
H5405_RS12760	COG0306	phosphate transporter
H5405_RS12775	COG5632	N-Acetylmuramoyl-L-alanine amidase
H5405_RS12775	COG3409	Peptidoglycan-binding domain 1 protein
H5405_RS12815	COG3778	Protein conserved in bacteria
H5405_RS12820	COG3299	homolog of phage Mu protein gp47
H5405_RS12825	COG3628	GPW Gp25 family protein
H5405_RS12835	COG4193	domain, Protein
H5405_RS12840	COG1652	LysM domain
H5405_RS12845	COG5412	phage tail tape measure protein
H5405_RS12845	COG3953	SLT domain
H5405_RS12845	COG3953	SLT domain
H5405_RS12845	COG5412	phage tail tape measure protein
H5405_RS12845	COG3953	SLT domain
H5405_RS12845	COG5412	phage tail tape measure protein
H5405_RS12895	COG4653	Phage capsid family
H5405_RS12900	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H5405_RS12905	COG5518	Phage portal protein
H5405_RS12915	COG3728	DNA packaging
H5405_RS12915	COG5484	DNA packaging
H5405_RS12920	COG1595	DNA-templated transcription, initiation
H5405_RS12940	COG1484	DNA-dependent DNA replication
H5405_RS12945	COG1522	sequence-specific DNA binding
H5405_RS12955	COG1396	sequence-specific DNA binding
H5405_RS12960	COG2856	Zn peptidase
H5405_RS12965	COG4195	phage-related replication protein
H5405_RS12975	COG3409	Peptidoglycan-binding domain 1 protein
H5405_RS12975	COG5632	N-Acetylmuramoyl-L-alanine amidase
H5405_RS12975	COG1388	LysM domain
H5405_RS12985	COG0457	Tetratricopeptide repeat
H5405_RS12990	COG2318	DinB family
H5405_RS12995	COG0730	response to heat
H5405_RS13000	COG2721	sulfolactate sulfo-lyase activity
H5405_RS13005	COG0246	Mannitol dehydrogenase
H5405_RS13010	COG1609	Transcriptional regulator
H5405_RS13015	COG2211	Major facilitator Superfamily
H5405_RS13025	COG1252	NADH dehydrogenase
H5405_RS13035	COG4297	protein containing double-stranded beta helix domain
H5405_RS13045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5405_RS13050	COG0390	transport system, permease component
H5405_RS13055	COG1587	Uroporphyrinogen-III synthase
H5405_RS13065	COG1819	glycosyl
H5405_RS13070	COG2124	cytochrome p450
H5405_RS13075	COG2427	Protein of unknown function (DUF1641)
H5405_RS13080	COG3383	formate dehydrogenase (NAD+) activity
H5405_RS13090	COG2205	protein histidine kinase activity
H5405_RS13105	COG1285	pathogenesis
H5405_RS13135	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5405_RS13140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS13140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5405_RS13145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5405_RS13150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5405_RS13155	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H5405_RS13165	COG1846	Transcriptional regulator
H5405_RS13170	COG0477	Major facilitator Superfamily
H5405_RS13175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5405_RS13180	COG2367	Beta-lactamase
H5405_RS13185	COG0346	lactoylglutathione lyase activity
H5405_RS13195	COG5444	nuclease activity
H5405_RS13210	COG0626	cystathionine gamma-synthase activity
H5405_RS13215	COG0626	cystathionine gamma-synthase activity
H5405_RS13220	COG2382	esterase
H5405_RS13230	COG2153	protein acetylation
H5405_RS13240	COG1131	(ABC) transporter
H5405_RS13260	COG0210	DNA helicase
H5405_RS13315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5405_RS13320	COG0351	phosphomethylpyrimidine kinase
H5405_RS13325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5405_RS13335	COG2104	thiamine diphosphate biosynthetic process
H5405_RS13340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5405_RS13345	COG0352	thiamine-phosphate diphosphorylase activity
H5405_RS13350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5405_RS13355	COG0569	domain protein
H5405_RS13355	COG0475	glutathione-regulated potassium exporter activity
H5405_RS13365	COG0564	pseudouridine synthase activity
H5405_RS13370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5405_RS13375	COG2357	RelA SpoT domain protein
H5405_RS13385	COG4116	CYTH
H5405_RS13390	COG0741	lytic transglycosylase activity
H5405_RS13395	COG2346	COG2346, Truncated hemoglobins
H5405_RS13400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H5405_RS13410	COG1164	Oligoendopeptidase f
H5405_RS13415	COG4469	Competence protein
H5405_RS13420	COG4862	establishment of competence for transformation
H5405_RS13430	COG0861	Integral membrane protein TerC family
H5405_RS13435	COG1393	Belongs to the ArsC family
H5405_RS13440	COG0456	acetyltransferase
H5405_RS13450	COG4608	Belongs to the ABC transporter superfamily
H5405_RS13455	COG0444	Belongs to the ABC transporter superfamily
H5405_RS13460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5405_RS13465	COG0601	transmembrane transport
H5405_RS13470	COG4166	transmembrane transport
H5405_RS13475	COG0180	Tryptophanyl-tRNA synthetase
H5405_RS13485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5405_RS13490	COG0601	transmembrane transport
H5405_RS13500	COG4608	Belongs to the ABC transporter superfamily
H5405_RS13505	COG0444	Belongs to the ABC transporter superfamily
H5405_RS13510	COG5504	Zn-dependent protease
H5405_RS13515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5405_RS13520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5405_RS13535	COG1744	ABC transporter substrate-binding protein PnrA-like
H5405_RS13545	COG2267	carboxylic ester hydrolase activity
H5405_RS13560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5405_RS13565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5405_RS13570	COG0505	Belongs to the CarA family
H5405_RS13575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5405_RS13585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5405_RS13595	COG2271	Major facilitator Superfamily
H5405_RS13600	COG0277	FAD linked oxidase domain protein
H5405_RS13610	COG2151	metal-sulfur cluster biosynthetic enzyme
H5405_RS13615	COG1073	alpha beta
H5405_RS13620	COG0561	phosphatase activity
H5405_RS13640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS13645	COG1307	EDD domain protein, DegV family
H5405_RS13655	COG2124	cytochrome p450
H5405_RS13660	COG0840	transmembrane signaling receptor activity
H5405_RS13665	COG1744	ABC transporter substrate-binding protein PnrA-like
H5405_RS13670	COG2996	Protein conserved in bacteria
H5405_RS13680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5405_RS13680	COG0646	methionine synthase
H5405_RS13685	COG2153	protein acetylation
H5405_RS13690	COG1357	PFAM Pentapeptide repeats (8 copies)
H5405_RS13695	COG2318	DinB family
H5405_RS13705	COG2207	Transcriptional regulator
H5405_RS13705	COG1917	Cupin 2, conserved barrel domain protein
H5405_RS13710	COG0534	Mate efflux family protein
H5405_RS13715	COG1562	ergosterol biosynthetic process
H5405_RS13720	COG0367	asparagine synthase
H5405_RS13740	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5405_RS13780	COG1403	HNH endonuclease
H5405_RS13785	COG0419	ATPase involved in DNA repair
H5405_RS13790	COG0420	3'-5' exonuclease activity
H5405_RS13805	COG2323	membrane
H5405_RS13810	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H5405_RS13820	COG2814	Major facilitator Superfamily
H5405_RS13825	COG3180	Ammonia monooxygenase
H5405_RS13830	COG1846	Transcriptional regulator
H5405_RS13835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5405_RS13840	COG0681	Belongs to the peptidase S26 family
H5405_RS13845	COG0398	Pfam SNARE associated Golgi protein
H5405_RS13860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5405_RS13885	COG5646	InterPro IPR014922
H5405_RS13895	COG4903	ComK protein
H5405_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5405_RS13910	COG0723	plastoquinol--plastocyanin reductase activity
H5405_RS13915	COG0840	transmembrane signaling receptor activity
H5405_RS13920	COG1268	BioY protein
H5405_RS13925	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS13930	COG0183	Belongs to the thiolase family
H5405_RS13935	COG0406	alpha-ribazole phosphatase activity
H5405_RS13940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5405_RS13945	COG1404	Belongs to the peptidase S8 family
H5405_RS13950	COG0501	Belongs to the peptidase M48B family
H5405_RS13960	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS13965	COG0702	epimerase
H5405_RS13970	COG0095	Lipoate-protein ligase
H5405_RS13975	COG1234	tRNA 3'-trailer cleavage
H5405_RS13985	COG1301	dicarboxylic acid transport
H5405_RS13990	COG1363	Peptidase, m42
H5405_RS14000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5405_RS14005	COG1511	domain protein
H5405_RS14010	COG1309	transcriptional regulator
H5405_RS14015	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H5405_RS14020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5405_RS14030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5405_RS14035	COG2329	Antibiotic biosynthesis monooxygenase
H5405_RS14040	COG3069	C4-dicarboxylate transmembrane transporter activity
H5405_RS14045	COG1473	amidohydrolase
H5405_RS14055	COG4473	ABC transporter
H5405_RS14060	COG1131	(ABC) transporter
H5405_RS14065	COG0537	adenosine 5'-monophosphoramidase activity
H5405_RS14070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5405_RS14085	COG4980	gas vesicle protein
H5405_RS14120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5405_RS14135	COG4717	serine-type aminopeptidase activity
H5405_RS14140	COG0420	3'-5' exonuclease activity
H5405_RS14145	COG1668	transmembrane transport
H5405_RS14150	COG4152	abc transporter atp-binding protein
H5405_RS14160	COG1024	Enoyl-CoA hydratase
H5405_RS14170	COG0490	domain, Protein
H5405_RS14175	COG0475	glutathione-regulated potassium exporter activity
H5405_RS14185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5405_RS14190	COG0561	phosphatase activity
H5405_RS14195	COG4335	DNA alkylation repair
H5405_RS14210	COG0189	ligase activity
H5405_RS14215	COG0189	ligase activity
H5405_RS14230	COG0702	epimerase
H5405_RS14235	COG1132	(ABC) transporter
H5405_RS14240	COG1132	(ABC) transporter
H5405_RS14245	COG0589	response to stress
H5405_RS14255	COG3226	Transcriptional regulator
H5405_RS14260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5405_RS14265	COG0726	polysaccharide deacetylase
H5405_RS14270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5405_RS14275	COG0668	transmembrane transport
H5405_RS14285	COG0584	glycerophosphoryl diester phosphodiesterase
H5405_RS14290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5405_RS14295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5405_RS14300	COG1253	flavin adenine dinucleotide binding
H5405_RS14305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5405_RS14310	COG0436	Aminotransferase
H5405_RS14315	COG0789	Transcriptional regulator
H5405_RS14320	COG1253	flavin adenine dinucleotide binding
H5405_RS14325	COG0204	Acyl-transferase
H5405_RS14330	COG1595	DNA-templated transcription, initiation
H5405_RS14345	COG0733	neurotransmitter:sodium symporter activity
H5405_RS14350	COG0531	amino acid
H5405_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS14360	COG0372	Belongs to the citrate synthase family
H5405_RS14365	COG0583	DNA-binding transcription factor activity
H5405_RS14370	COG1388	LysM domain
H5405_RS14370	COG0791	NLP P60 protein
H5405_RS14375	COG1785	Belongs to the alkaline phosphatase family
H5405_RS14380	COG2719	SpoVR family
H5405_RS14385	COG0668	transmembrane transport
H5405_RS14390	COG1959	2 iron, 2 sulfur cluster binding
H5405_RS14395	COG0791	NLP P60 protein
H5405_RS14395	COG1388	LysM domain
H5405_RS14410	COG0431	NADPH-dependent FMN reductase
H5405_RS14415	COG2197	response regulator
H5405_RS14420	COG4585	Histidine kinase
H5405_RS14420	COG2203	Gaf domain
H5405_RS14425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5405_RS14430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5405_RS14440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5405_RS14445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H5405_RS14450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5405_RS14455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5405_RS14455	COG3153	acetyltransferase
H5405_RS14460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5405_RS14465	COG0517	IMP dehydrogenase activity
H5405_RS14475	COG0564	pseudouridine synthase activity
H5405_RS14480	COG3764	Sortase (surface protein transpeptidase)
H5405_RS14485	COG1525	nuclease
H5405_RS14485	COG0737	Belongs to the 5'-nucleotidase family
H5405_RS14485	COG4085	toxin activity
H5405_RS14490	COG5577	PFAM Coat F domain
H5405_RS14510	COG1823	symporter activity
H5405_RS14515	COG3706	GGDEF domain
H5405_RS14520	COG1464	Belongs to the NlpA lipoprotein family
H5405_RS14525	COG1278	Cold shock
H5405_RS14530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H5405_RS14535	COG1131	(ABC) transporter
H5405_RS14540	COG1131	(ABC) transporter
H5405_RS14545	COG1725	Transcriptional regulator
H5405_RS14560	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5405_RS14565	COG2814	Major facilitator Superfamily
H5405_RS14570	COG1566	PFAM secretion protein HlyD family protein
H5405_RS14575	COG1846	Transcriptional regulator
H5405_RS14585	COG2766	serine protein kinase
H5405_RS14590	COG1664	Polymer-forming cytoskeletal
H5405_RS14595	COG1664	Polymer-forming cytoskeletal
H5405_RS14600	COG0789	Transcriptional regulator
H5405_RS14605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5405_RS14615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5405_RS14620	COG3382	B3 4 domain protein
H5405_RS14630	COG1476	TRANSCRIPTIONal
H5405_RS14650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5405_RS14655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5405_RS14660	COG1116	anion transmembrane transporter activity
H5405_RS14670	COG0753	catalase activity
H5405_RS14675	COG4608	Belongs to the ABC transporter superfamily
H5405_RS14680	COG0444	Belongs to the ABC transporter superfamily
H5405_RS14685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5405_RS14690	COG0601	transmembrane transport
H5405_RS14695	COG0747	negative chemotaxis
H5405_RS14705	COG0277	FAD linked oxidase domain protein
H5405_RS14715	COG3340	Belongs to the peptidase S51 family
H5405_RS14720	COG1757	Na H antiporter
H5405_RS14830	COG0735	belongs to the Fur family
H5405_RS14835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5405_RS14845	COG4129	membrane
H5405_RS14850	COG1132	(ABC) transporter
H5405_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS14880	COG1194	a g-specific adenine glycosylase
H5405_RS14885	COG1988	membrane-bound metal-dependent
H5405_RS14890	COG4485	Bacterial membrane protein, YfhO
H5405_RS14895	COG0463	Glycosyl transferase, family 2
H5405_RS14900	COG0596	Alpha beta hydrolase
H5405_RS14905	COG5658	integral membrane protein
H5405_RS14910	COG3103	Sh3 type 3 domain protein
H5405_RS14925	COG3591	Belongs to the peptidase S1B family
H5405_RS14935	COG2814	Major facilitator Superfamily
H5405_RS14950	COG1090	epimerase
H5405_RS14965	COG0778	Nitroreductase
H5405_RS14970	COG0384	phenazine biosynthesis protein PhzF
H5405_RS14975	COG0392	lysyltransferase activity
H5405_RS14975	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H5405_RS14980	COG1846	Transcriptional regulator
H5405_RS14985	COG2814	Major facilitator Superfamily
H5405_RS14990	COG2318	DinB family
H5405_RS14995	COG2732	(Barnase) inhibitor
H5405_RS15000	COG0574	Belongs to the PEP-utilizing enzyme family
H5405_RS15000	COG3848	Pyruvate phosphate dikinase
H5405_RS15005	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H5405_RS15010	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5405_RS15015	COG1695	Transcriptional regulator
H5405_RS15025	COG2514	catechol 2,3-dioxygenase activity
H5405_RS15030	COG2259	Doxx family
H5405_RS15035	COG1132	(ABC) transporter
H5405_RS15040	COG1132	(ABC) transporter
H5405_RS15045	COG5434	Belongs to the glycosyl hydrolase 28 family
H5405_RS15050	COG1263	PTS System
H5405_RS15050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS15055	COG1737	Transcriptional regulator
H5405_RS15060	COG1486	melibiose metabolic process
H5405_RS15070	COG3284	Transcriptional regulator
H5405_RS15075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5405_RS15080	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5405_RS15085	COG0022	dehydrogenase e1 component
H5405_RS15090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5405_RS15100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5405_RS15110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5405_RS15115	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H5405_RS15120	COG0598	Magnesium transport protein CorA
H5405_RS15130	COG2084	Dehydrogenase
H5405_RS15135	COG0726	polysaccharide deacetylase
H5405_RS15145	COG0535	radical SAM domain protein
H5405_RS15150	COG0668	transmembrane transport
H5405_RS15160	COG0387	Pfam Sodium calcium exchanger
H5405_RS15165	COG0477	Major facilitator Superfamily
H5405_RS15170	COG1295	ribonuclease BN
H5405_RS15175	COG4980	gas vesicle protein
H5405_RS15180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5405_RS15190	COG2814	Major facilitator Superfamily
H5405_RS15205	COG1609	Transcriptional regulator
H5405_RS15210	COG0693	protein deglycase activity
H5405_RS15215	COG0737	Belongs to the 5'-nucleotidase family
H5405_RS15230	COG0778	Nitroreductase
H5405_RS15235	COG2188	Transcriptional regulator
H5405_RS15240	COG0366	Alpha amylase catalytic
H5405_RS15245	COG1263	PTS System
H5405_RS15245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS15260	COG0071	Belongs to the small heat shock protein (HSP20) family
H5405_RS15270	COG1368	sulfuric ester hydrolase activity
H5405_RS15280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS15280	COG1263	PTS System
H5405_RS15285	COG0024	Methionine aminopeptidase
H5405_RS15305	COG2258	MOSC domain
H5405_RS15315	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H5405_RS15320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5405_RS15325	COG2851	Citrate transporter
H5405_RS15330	COG3181	Tripartite tricarboxylate transporter family receptor
H5405_RS15335	COG4565	transcriptional regulatory protein
H5405_RS15340	COG3290	protein histidine kinase activity
H5405_RS15345	COG3764	Sortase (surface protein transpeptidase)
H5405_RS15355	COG3279	Response regulator of the LytR AlgR family
H5405_RS15360	COG0745	RESPONSE REGULATOR receiver
H5405_RS15360	COG2972	Histidine kinase
H5405_RS15380	COG0471	metal ion transport
H5405_RS15385	COG3866	Pectate lyase
H5405_RS15400	COG2130	NADP-dependent
H5405_RS15410	COG0513	Belongs to the DEAD box helicase family
H5405_RS15415	COG0488	(ABC) transporter
H5405_RS15420	COG2814	Major facilitator Superfamily
H5405_RS15425	COG0789	Transcriptional regulator
H5405_RS15430	COG0488	(ABC) transporter
H5405_RS15435	COG0457	Tetratricopeptide repeat
H5405_RS15435	COG0463	Glycosyl transferase, family 2
H5405_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS15445	COG0840	transmembrane signaling receptor activity
H5405_RS15450	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS15455	COG0531	amino acid
H5405_RS15460	COG2223	nitrite transmembrane transporter activity
H5405_RS15465	COG1442	glycosyl transferase family 8
H5405_RS15470	COG1216	Glycosyl transferase, family 2
H5405_RS15475	COG1442	glycosyl transferase family 8
H5405_RS15480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5405_RS15485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5405_RS15490	COG1368	sulfuric ester hydrolase activity
H5405_RS15500	COG1131	(ABC) transporter
H5405_RS15515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5405_RS15515	COG2124	cytochrome p450
H5405_RS15525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5405_RS15530	COG1846	Transcriptional regulator
H5405_RS15535	COG0670	Belongs to the BI1 family
H5405_RS15540	COG0196	riboflavin kinase activity
H5405_RS15545	COG5583	Uncharacterized small protein (DUF2292)
H5405_RS15550	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS15555	COG0346	lactoylglutathione lyase activity
H5405_RS15560	COG2329	Antibiotic biosynthesis monooxygenase
H5405_RS15565	COG2323	membrane
H5405_RS15575	COG0454	-acetyltransferase
H5405_RS15580	COG3546	catalase activity
H5405_RS15610	COG5444	nuclease activity
H5405_RS15645	COG1131	(ABC) transporter
H5405_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS15660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5405_RS15670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5405_RS15680	COG2197	response regulator
H5405_RS15685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5405_RS15690	COG1597	lipid kinase activity
H5405_RS15695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5405_RS15700	COG1309	transcriptional regulator
H5405_RS15720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5405_RS15725	COG1285	pathogenesis
H5405_RS15730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5405_RS15735	COG4851	CamS sex pheromone cAM373 precursor
H5405_RS15745	COG0210	DNA helicase
H5405_RS15755	COG0069	glutamate synthase activity
H5405_RS15760	COG4496	protein, YerC YecD
H5405_RS15765	COG1470	cell adhesion involved in biofilm formation
H5405_RS15770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5405_RS15780	COG0151	Belongs to the GarS family
H5405_RS15785	COG0138	bifunctional purine biosynthesis protein purh
H5405_RS15790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5405_RS15800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5405_RS15815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5405_RS15820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5405_RS15825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5405_RS15830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5405_RS15835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5405_RS15855	COG3064	Membrane
H5405_RS15860	COG2252	PERMEase
H5405_RS15885	COG1305	Transglutaminase-like
H5405_RS15890	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H5405_RS15895	COG0714	Associated with various cellular activities
H5405_RS15900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5405_RS15905	COG1113	amino acid transport
H5405_RS15910	COG2132	Multicopper oxidase
H5405_RS15925	COG0823	Involved in the tonB-independent uptake of proteins
H5405_RS15930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5405_RS15935	COG1063	alcohol dehydrogenase
H5405_RS15940	COG1595	DNA-templated transcription, initiation
H5405_RS15950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5405_RS15950	COG2755	lipolytic protein G-D-S-L family
H5405_RS15955	COG4260	virion core protein, lumpy skin disease virus
H5405_RS15960	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H5405_RS15965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5405_RS15970	COG1842	Phage shock protein A
H5405_RS15980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5405_RS15985	COG2211	Major facilitator Superfamily
H5405_RS15990	COG1063	alcohol dehydrogenase
H5405_RS15995	COG0457	Tetratricopeptide repeat
H5405_RS16000	COG1073	alpha beta
H5405_RS16015	COG1266	CAAX protease self-immunity
H5405_RS16025	COG0805	protein transport
H5405_RS16030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5405_RS16045	COG0488	(ABC) transporter
H5405_RS16050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5405_RS16055	COG0456	acetyltransferase
H5405_RS16060	COG1214	PFAM Peptidase M22, glycoprotease
H5405_RS16065	COG0802	atpase or kinase
H5405_RS16070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5405_RS16110	COG2814	Major facilitator Superfamily
H5405_RS16115	COG0604	alcohol dehydrogenase
H5405_RS16120	COG3832	glyoxalase III activity
H5405_RS16130	COG0531	amino acid
H5405_RS16135	COG1309	transcriptional regulator
H5405_RS16140	COG2076	Multidrug Resistance protein
H5405_RS16145	COG2076	Multidrug Resistance protein
H5405_RS16150	COG2807	transmembrane transport
H5405_RS16155	COG2186	Transcriptional regulator
H5405_RS16160	COG2188	Transcriptional regulator
H5405_RS16165	COG2814	Major facilitator Superfamily
H5405_RS16170	COG1388	LysM domain
H5405_RS16180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5405_RS16195	COG1819	glycosyl
H5405_RS16200	COG1802	Transcriptional regulator
H5405_RS16205	COG0473	3-isopropylmalate dehydrogenase activity
H5405_RS16210	COG0596	Alpha beta hydrolase
H5405_RS16215	COG1051	belongs to the nudix hydrolase family
H5405_RS16220	COG0697	spore germination
H5405_RS16225	COG0789	Transcriptional regulator
H5405_RS16225	COG4978	Transcriptional regulator
H5405_RS16230	COG0456	acetyltransferase
H5405_RS16235	COG0730	response to heat
H5405_RS16245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5405_RS16250	COG2814	Major facilitator Superfamily
H5405_RS16260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5405_RS16265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5405_RS16270	COG0488	(ABC) transporter
H5405_RS16275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H5405_RS16280	COG2409	Drug exporters of the RND superfamily
H5405_RS16285	COG2197	response regulator
H5405_RS16290	COG4585	Histidine kinase
H5405_RS16300	COG5577	PFAM Coat F domain
H5405_RS16305	COG1063	alcohol dehydrogenase
H5405_RS16315	COG5577	PFAM Coat F domain
H5405_RS16320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS16325	COG0697	spore germination
H5405_RS16330	COG1309	transcriptional regulator
H5405_RS16335	COG2814	Major facilitator Superfamily
H5405_RS16345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS16355	COG0789	Transcriptional regulator
H5405_RS16360	COG1064	alcohol dehydrogenase
H5405_RS16385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5405_RS16390	COG2318	DinB family
H5405_RS16395	COG0662	Cupin 2, conserved barrel domain protein
H5405_RS16420	COG0277	FAD linked oxidase domain protein
H5405_RS16435	COG0662	Cupin 2, conserved barrel domain protein
H5405_RS16445	COG3621	Patatin-like phospholipase
H5405_RS16450	COG2271	Major facilitator Superfamily
H5405_RS16455	COG1846	Transcriptional regulator
H5405_RS16455	COG0456	acetyltransferase
H5405_RS16470	COG1794	racemase activity, acting on amino acids and derivatives
H5405_RS16475	COG1329	Transcriptional regulator
H5405_RS16480	COG1278	Cold shock
H5405_RS16490	COG3239	Fatty acid desaturase
H5405_RS16500	COG0300	oxidoreductase activity
H5405_RS16505	COG1309	transcriptional regulator
H5405_RS16510	COG2910	NAD(P)H-binding
H5405_RS16515	COG1959	2 iron, 2 sulfur cluster binding
H5405_RS16530	COG2030	dehydratase
H5405_RS16540	COG1846	Transcriptional regulator
H5405_RS16545	COG0477	Major facilitator Superfamily
H5405_RS16550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5405_RS16555	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5405_RS16615	COG2183	response to ionizing radiation
H5405_RS16620	COG2208	phosphoserine phosphatase activity
H5405_RS16625	COG1191	sigma factor activity
H5405_RS16635	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS16640	COG2208	phosphoserine phosphatase activity
H5405_RS16645	COG2172	sigma factor antagonist activity
H5405_RS16650	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS16655	COG1366	Belongs to the anti-sigma-factor antagonist family
H5405_RS16660	COG2337	Toxic component of a toxin-antitoxin (TA) module
H5405_RS16665	COG0864	Transcriptional regulator
H5405_RS16670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5405_RS16675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5405_RS16685	COG0705	Rhomboid family
H5405_RS16690	COG3428	Bacterial PH domain
H5405_RS16695	COG3402	PFAM membrane-flanked domain
H5405_RS16700	COG0513	Belongs to the DEAD box helicase family
H5405_RS16705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5405_RS16715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS16720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5405_RS16735	COG1960	acyl-CoA dehydrogenase activity
H5405_RS16745	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H5405_RS16750	COG1131	(ABC) transporter
H5405_RS16755	COG0628	permease
H5405_RS16760	COG1301	dicarboxylic acid transport
H5405_RS16765	COG4565	transcriptional regulatory protein
H5405_RS16770	COG3290	protein histidine kinase activity
H5405_RS16775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5405_RS16780	COG3546	catalase activity
H5405_RS16790	COG0662	Cupin 2, conserved barrel domain protein
H5405_RS16795	COG3729	General stress protein
H5405_RS16800	COG2217	Heavy metal translocating P-type atpase
H5405_RS16805	COG2076	Multidrug Resistance protein
H5405_RS16825	COG1914	H( )-stimulated, divalent metal cation uptake system
H5405_RS16845	COG0457	Tetratricopeptide repeat
H5405_RS16880	COG0494	nUDIX hydrolase
H5405_RS16885	COG0531	amino acid
H5405_RS16895	COG1215	transferase activity, transferring glycosyl groups
H5405_RS16900	COG5298	Protein conserved in bacteria
H5405_RS16905	COG3706	GGDEF domain
H5405_RS16910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H5405_RS16915	COG0551	DNA topoisomerase type I activity
H5405_RS16915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5405_RS16920	COG1522	sequence-specific DNA binding
H5405_RS16925	COG2814	Major facilitator Superfamily
H5405_RS16935	COG3871	stress protein (general stress protein 26)
H5405_RS16940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5405_RS16945	COG1917	Cupin 2, conserved barrel domain protein
H5405_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS16955	COG0318	PFAM AMP-dependent synthetase and ligase
H5405_RS16960	COG3711	transcriptional antiterminator
H5405_RS16965	COG4989	oxidoreductase activity
H5405_RS16970	COG0768	penicillin binding
H5405_RS16975	COG2329	Antibiotic biosynthesis monooxygenase
H5405_RS16985	COG2755	lipolytic protein G-D-S-L family
H5405_RS16990	COG1414	Transcriptional regulator
H5405_RS16995	COG1984	allophanate hydrolase subunit 2
H5405_RS17000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5405_RS17010	COG1914	H( )-stimulated, divalent metal cation uptake system
H5405_RS17020	COG0561	phosphatase activity
H5405_RS17030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5405_RS17040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5405_RS17045	COG2213	PTS system mannitol-specific
H5405_RS17055	COG1349	DNA-binding transcription factor activity
H5405_RS17060	COG1276	copper resistance
H5405_RS17060	COG2372	response to copper ion
H5405_RS17065	COG4549	nuclear export factor GLE1
H5405_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS17075	COG4975	Glucose uptake
H5405_RS17080	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS17085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5405_RS17090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS17095	COG0640	Transcriptional regulator
H5405_RS17100	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5405_RS17105	COG0778	Nitroreductase
H5405_RS17110	COG1309	transcriptional regulator
H5405_RS17115	COG2814	Major facilitator Superfamily
H5405_RS17120	COG4607	ABC-type enterochelin transport system periplasmic component
H5405_RS17125	COG4604	ABC transporter, ATP-binding protein
H5405_RS17130	COG4605	iron ion homeostasis
H5405_RS17135	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS17140	COG0527	aspartate kinase activity
H5405_RS17155	COG0457	Tetratricopeptide repeat
H5405_RS17160	COG5002	protein histidine kinase activity
H5405_RS17160	COG3850	Histidine kinase
H5405_RS17165	COG0745	RESPONSE REGULATOR receiver
H5405_RS17170	COG0577	efflux transmembrane transporter activity
H5405_RS17175	COG1136	(ABC) transporter
H5405_RS17180	COG2079	MmgE PrpD family protein
H5405_RS17185	COG1473	amidohydrolase
H5405_RS17190	COG1126	abc transporter atp-binding protein
H5405_RS17195	COG0765	amino acid transport
H5405_RS17200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS17205	COG0456	acetyltransferase
H5405_RS17210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS17215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5405_RS17225	COG0697	spore germination
H5405_RS17235	COG5434	Belongs to the glycosyl hydrolase 28 family
H5405_RS17240	COG3104	oligopeptide transport
H5405_RS17255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5405_RS17260	COG0163	prenyltransferase activity
H5405_RS17265	COG0583	DNA-binding transcription factor activity
H5405_RS17270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5405_RS17275	COG0765	amino acid transport
H5405_RS17280	COG1126	abc transporter atp-binding protein
H5405_RS17285	COG2364	Membrane
H5405_RS17295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5405_RS17300	COG0697	spore germination
H5405_RS17315	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H5405_RS17320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS17325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS17330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5405_RS17335	COG1733	regulation of RNA biosynthetic process
H5405_RS17340	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H5405_RS17345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5405_RS17350	COG3209	COG3209 Rhs family protein
H5405_RS17365	COG1714	RDD family
H5405_RS17370	COG1063	alcohol dehydrogenase
H5405_RS17375	COG0523	cobalamin synthesis protein
H5405_RS17380	COG2223	nitrite transmembrane transporter activity
H5405_RS17385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5405_RS17390	COG0243	molybdopterin cofactor binding
H5405_RS17395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5405_RS17400	COG2146	nitrite reductase [NAD(P)H] activity
H5405_RS17405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5405_RS17405	COG1587	Uroporphyrinogen-III synthase
H5405_RS17415	COG2508	Transcriptional regulator
H5405_RS17420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5405_RS17425	COG1012	belongs to the aldehyde dehydrogenase family
H5405_RS17430	COG0506	proline dehydrogenase activity
H5405_RS17435	COG3541	Predicted nucleotidyltransferase
H5405_RS17440	COG3458	cephalosporin-C deacetylase activity
H5405_RS17445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5405_RS17450	COG2271	Major facilitator Superfamily
H5405_RS17455	COG1082	Xylose isomerase domain protein TIM barrel
H5405_RS17470	COG3665	Urea carboxylase-associated protein
H5405_RS17475	COG1113	amino acid transport
H5405_RS17480	COG3403	YqcI/YcgG family
H5405_RS17485	COG1280	lysine exporter protein (LysE YggA)
H5405_RS17490	COG1846	Transcriptional regulator
H5405_RS17495	COG2814	Major facilitator Superfamily
H5405_RS17505	COG0366	Alpha amylase catalytic
H5405_RS17515	COG1288	antiporter activity
H5405_RS17520	COG1473	amidohydrolase
H5405_RS17525	COG2113	Glycine betaine
H5405_RS17530	COG4176	ABC-type proline glycine betaine transport system permease component
H5405_RS17535	COG4175	Glycine betaine
H5405_RS17535	COG0517	IMP dehydrogenase activity
H5405_RS17540	COG0477	Major facilitator Superfamily
H5405_RS17545	COG3853	Toxic anion resistance protein (TelA)
H5405_RS17555	COG0861	Integral membrane protein TerC family
H5405_RS17560	COG2310	stress, protein
H5405_RS17565	COG2310	stress, protein
H5405_RS17570	COG2310	stress, protein
H5405_RS17575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5405_RS17580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5405_RS17585	COG1121	(ABC) transporter
H5405_RS17590	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5405_RS17595	COG0366	Alpha amylase catalytic
H5405_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
H5405_RS17605	COG0457	Tetratricopeptide repeat
H5405_RS17610	COG1876	peptidase activity
H5405_RS17615	COG1595	DNA-templated transcription, initiation
H5405_RS17620	COG1595	DNA-templated transcription, initiation
H5405_RS17630	COG0667	Aldo Keto reductase
H5405_RS17635	COG3012	SEC-C Motif Domain Protein
H5405_RS17635	COG1405	negative regulation of cell septum assembly
H5405_RS17640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H5405_RS17645	COG0252	asparaginase activity
H5405_RS17650	COG1309	transcriptional regulator
H5405_RS17655	COG0477	Major facilitator Superfamily
H5405_RS17660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5405_RS17670	COG0805	protein transport
H5405_RS17675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5405_RS17680	COG3540	Alkaline phosphatase
H5405_RS17685	COG3773	Cell wall hydrolase
H5405_RS17700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5405_RS17705	COG2259	Doxx family
H5405_RS17710	COG0346	lactoylglutathione lyase activity
H5405_RS17715	COG0778	Nitroreductase
H5405_RS17720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5405_RS17735	COG3173	Aminoglycoside phosphotransferase
H5405_RS17740	COG0784	Response regulator, receiver
H5405_RS17745	COG4191	Histidine kinase
H5405_RS17750	COG2066	Belongs to the glutaminase family
H5405_RS17755	COG1115	amino acid carrier protein
H5405_RS17760	COG2040	homocysteine
H5405_RS17765	COG0833	amino acid
H5405_RS17770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5405_RS17775	COG1301	dicarboxylic acid transport
H5405_RS17790	COG0688	phosphatidylethanolamine metabolic process
H5405_RS17795	COG0586	Pfam SNARE associated Golgi protein
H5405_RS17800	COG1183	phosphatidylcholine synthase activity
H5405_RS17810	COG0371	Dehydrogenase
H5405_RS17835	COG2368	4-hydroxyphenylacetate
H5405_RS17845	COG2271	Major facilitator Superfamily
H5405_RS17850	COG0584	glycerophosphoryl diester phosphodiesterase
H5405_RS17865	COG0531	amino acid
H5405_RS17905	COG1131	(ABC) transporter
H5405_RS17910	COG2197	response regulator
H5405_RS17915	COG4585	Histidine kinase
H5405_RS17920	COG1011	Hydrolase
H5405_RS17925	COG1113	amino acid transport
H5405_RS17930	COG1846	Transcriptional regulator
H5405_RS17935	COG1380	Effector of murein hydrolase LrgA
H5405_RS17940	COG1346	cytolysis
H5405_RS17955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5405_RS17960	COG0577	efflux transmembrane transporter activity
H5405_RS17965	COG1136	(ABC) transporter
H5405_RS17970	COG5002	protein histidine kinase activity
H5405_RS18010	COG4856	YbbR-like protein
H5405_RS18015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H5405_RS18020	COG5662	AntiSigma factor
H5405_RS18025	COG1595	DNA-templated transcription, initiation
H5405_RS18055	COG1683	Conserved Protein
H5405_RS18060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5405_RS18070	COG1263	PTS System
H5405_RS18070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5405_RS18075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5405_RS18080	COG1472	Belongs to the glycosyl hydrolase 3 family
H5405_RS18085	COG3876	Protein conserved in bacteria
H5405_RS18090	COG2207	Transcriptional regulator
H5405_RS18090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5405_RS18095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5405_RS18100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS18105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5405_RS18110	COG2819	hydrolase of the alpha beta superfamily
H5405_RS18115	COG0385	Bile acid
H5405_RS18120	COG0659	secondary active sulfate transmembrane transporter activity
H5405_RS18135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5405_RS18140	COG0738	Major facilitator superfamily
H5405_RS18200	COG0726	polysaccharide deacetylase
H5405_RS18205	COG2194	sulfuric ester hydrolase activity
H5405_RS18215	COG0489	protein tyrosine kinase activity
H5405_RS18220	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5405_RS18235	COG2226	methyltransferase
H5405_RS18255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H5405_RS18260	COG1122	ATPase activity
H5405_RS18265	COG1122	ATPase activity
H5405_RS18290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5405_RS18300	COG0024	Methionine aminopeptidase
H5405_RS18310	COG0201	protein transport
H5405_RS18420	COG0596	Alpha beta hydrolase
H5405_RS18445	COG1358	cellular component organization or biogenesis
H5405_RS18460	COG2813	Specifically methylates the guanine in position
H5405_RS18485	COG0250	Participates in transcription elongation, termination and antitermination
H5405_RS18490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5405_RS18500	COG1595	DNA-templated transcription, initiation
H5405_RS18505	COG3688	RNA-binding protein containing a PIN domain
H5405_RS18510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5405_RS18515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H5405_RS18525	COG1045	serine acetyltransferase
H5405_RS18545	COG4956	integral membrane protein (PIN domain superfamily)
H5405_RS18550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H5405_RS18555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5405_RS18560	COG0542	response to heat
H5405_RS18570	COG3880	PFAM UvrB UvrC protein
H5405_RS18575	COG4463	regulation of RNA biosynthetic process
H5405_RS18655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5405_RS18660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5405_RS18665	COG1396	sequence-specific DNA binding
H5405_RS18670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5405_RS18675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5405_RS18680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5405_RS18685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5405_RS18690	COG0512	Glutamine amidotransferase of anthranilate synthase
H5405_RS18695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5405_RS18700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5405_RS18705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5405_RS18720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5405_RS18725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H5405_RS18730	COG0037	tRNA processing
H5405_RS18735	COG0515	serine threonine protein kinase
H5405_RS18740	COG2304	oxidoreductase activity
H5405_RS18745	COG2208	phosphoserine phosphatase activity
H5405_RS18760	COG1098	S1 RNA binding domain
H5405_RS18765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5405_RS18780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5405_RS18785	COG3956	TIGRFAM MazG family protein
H5405_RS18790	COG2244	polysaccharide biosynthetic process
H5405_RS18795	COG2002	toxin-antitoxin pair type II binding
H5405_RS18800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5405_RS18820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5405_RS18835	COG0251	oxidation-reduction process
H5405_RS18840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5405_RS18855	COG4466	Protein conserved in bacteria
H5405_RS18865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5405_RS18870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H5405_RS18875	COG3583	domain protein
H5405_RS18875	COG3584	3D domain protein
H5405_RS18880	COG0084	hydrolase, TatD family'
H5405_RS18885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5405_RS18885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5405_RS18890	COG2002	toxin-antitoxin pair type II binding
H5405_RS18895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5405_RS18905	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H5405_RS18915	COG1774	PSP1 C-terminal conserved region
H5405_RS18920	COG0470	DNA polymerase III
H5405_RS18925	COG1728	Protein conserved in bacteria
H5405_RS18930	COG3870	Protein conserved in bacteria
H5405_RS18940	COG1982	Orn Lys Arg decarboxylase major
H5405_RS18945	COG3853	Toxic anion resistance protein (TelA)
H5405_RS18950	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H5405_RS18995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5405_RS19000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5405_RS19005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5405_RS19015	COG0590	tRNA wobble adenosine to inosine editing
H5405_RS19020	COG1335	isochorismatase
H5405_RS19025	COG3858	chitin binding
H5405_RS19025	COG1388	LysM domain
H5405_RS19030	COG1428	Deoxynucleoside kinase
H5405_RS19035	COG1428	Deoxynucleoside kinase
H5405_RS19045	COG1929	Belongs to the glycerate kinase type-1 family
H5405_RS19065	COG1686	Belongs to the peptidase S11 family
H5405_RS19070	COG0517	IMP dehydrogenase activity
H5405_RS19070	COG0516	GMP reductase activity