locus-tag	class	description
M8X21_RS00010	COG0592	DNA-directed DNA polymerase activity
M8X21_RS00015	COG2501	S4 domain
M8X21_RS00030	COG0187	DNA topoisomerase II activity
M8X21_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8X21_RS00070	COG0516	GMP reductase activity
M8X21_RS00070	COG0517	IMP dehydrogenase activity
M8X21_RS00075	COG1686	Belongs to the peptidase S11 family
M8X21_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
M8X21_RS00105	COG1428	Deoxynucleoside kinase
M8X21_RS00110	COG1428	Deoxynucleoside kinase
M8X21_RS00115	COG1388	LysM domain
M8X21_RS00115	COG3858	chitin binding
M8X21_RS00120	COG1335	isochorismatase
M8X21_RS00125	COG0590	tRNA wobble adenosine to inosine editing
M8X21_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M8X21_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M8X21_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M8X21_RS00195	COG3853	Toxic anion resistance protein (TelA)
M8X21_RS00200	COG1982	Orn Lys Arg decarboxylase major
M8X21_RS00210	COG3870	Protein conserved in bacteria
M8X21_RS00215	COG1728	Protein conserved in bacteria
M8X21_RS00220	COG0470	DNA polymerase III
M8X21_RS00225	COG1774	PSP1 C-terminal conserved region
M8X21_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M8X21_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M8X21_RS00250	COG2002	toxin-antitoxin pair type II binding
M8X21_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8X21_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8X21_RS00260	COG0084	hydrolase, TatD family'
M8X21_RS00265	COG3584	3D domain protein
M8X21_RS00265	COG3583	domain protein
M8X21_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8X21_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M8X21_RS00285	COG4466	Protein conserved in bacteria
M8X21_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8X21_RS00305	COG0251	oxidation-reduction process
M8X21_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M8X21_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M8X21_RS00345	COG2002	toxin-antitoxin pair type II binding
M8X21_RS00350	COG2244	polysaccharide biosynthetic process
M8X21_RS00355	COG3956	TIGRFAM MazG family protein
M8X21_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M8X21_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M8X21_RS00380	COG1098	S1 RNA binding domain
M8X21_RS00395	COG2208	phosphoserine phosphatase activity
M8X21_RS00400	COG2304	oxidoreductase activity
M8X21_RS00405	COG0515	serine threonine protein kinase
M8X21_RS00410	COG0037	tRNA processing
M8X21_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M8X21_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M8X21_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8X21_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8X21_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8X21_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
M8X21_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M8X21_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M8X21_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M8X21_RS00475	COG1396	sequence-specific DNA binding
M8X21_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8X21_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M8X21_RS00565	COG4463	regulation of RNA biosynthetic process
M8X21_RS00570	COG3880	PFAM UvrB UvrC protein
M8X21_RS00580	COG0542	response to heat
M8X21_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M8X21_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M8X21_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
M8X21_RS00615	COG1045	serine acetyltransferase
M8X21_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M8X21_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8X21_RS00635	COG3688	RNA-binding protein containing a PIN domain
M8X21_RS00640	COG1595	DNA-templated transcription, initiation
M8X21_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8X21_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
M8X21_RS00680	COG2813	Specifically methylates the guanine in position
M8X21_RS00695	COG1358	cellular component organization or biogenesis
M8X21_RS00720	COG0596	Alpha beta hydrolase
M8X21_RS00830	COG0201	protein transport
M8X21_RS00840	COG0024	Methionine aminopeptidase
M8X21_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M8X21_RS00880	COG1122	ATPase activity
M8X21_RS00885	COG1122	ATPase activity
M8X21_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8X21_RS00910	COG2226	methyltransferase
M8X21_RS00915	COG2318	DinB family
M8X21_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS00930	COG0489	protein tyrosine kinase activity
M8X21_RS00940	COG2194	sulfuric ester hydrolase activity
M8X21_RS00945	COG0726	polysaccharide deacetylase
M8X21_RS01005	COG0738	Major facilitator superfamily
M8X21_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
M8X21_RS01030	COG0385	Bile acid
M8X21_RS01035	COG2819	hydrolase of the alpha beta superfamily
M8X21_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8X21_RS01055	COG2207	Transcriptional regulator
M8X21_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8X21_RS01060	COG3876	Protein conserved in bacteria
M8X21_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
M8X21_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8X21_RS01075	COG1263	PTS System
M8X21_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8X21_RS01090	COG1683	Conserved Protein
M8X21_RS01120	COG1595	DNA-templated transcription, initiation
M8X21_RS01125	COG5662	AntiSigma factor
M8X21_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8X21_RS01135	COG4856	YbbR-like protein
M8X21_RS01175	COG1346	cytolysis
M8X21_RS01180	COG1380	Effector of murein hydrolase LrgA
M8X21_RS01185	COG1846	Transcriptional regulator
M8X21_RS01190	COG1113	amino acid transport
M8X21_RS01195	COG1011	Hydrolase
M8X21_RS01200	COG4585	Histidine kinase
M8X21_RS01205	COG2197	response regulator
M8X21_RS01210	COG1131	(ABC) transporter
M8X21_RS01250	COG0531	amino acid
M8X21_RS01275	COG0584	glycerophosphoryl diester phosphodiesterase
M8X21_RS01280	COG2271	Major facilitator Superfamily
M8X21_RS01290	COG2368	4-hydroxyphenylacetate
M8X21_RS01300	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS01315	COG0371	Dehydrogenase
M8X21_RS01325	COG1183	phosphatidylcholine synthase activity
M8X21_RS01330	COG0586	Pfam SNARE associated Golgi protein
M8X21_RS01335	COG0688	phosphatidylethanolamine metabolic process
M8X21_RS01350	COG1301	dicarboxylic acid transport
M8X21_RS01355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS01360	COG0833	amino acid
M8X21_RS01365	COG2040	homocysteine
M8X21_RS01370	COG1115	amino acid carrier protein
M8X21_RS01375	COG2066	Belongs to the glutaminase family
M8X21_RS01380	COG4191	Histidine kinase
M8X21_RS01385	COG0784	Response regulator, receiver
M8X21_RS01390	COG3173	Aminoglycoside phosphotransferase
M8X21_RS01405	COG3773	Cell wall hydrolase
M8X21_RS01410	COG3540	Alkaline phosphatase
M8X21_RS01415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8X21_RS01420	COG0805	protein transport
M8X21_RS01430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8X21_RS01435	COG0477	Major facilitator Superfamily
M8X21_RS01440	COG1309	transcriptional regulator
M8X21_RS01445	COG0252	asparaginase activity
M8X21_RS01450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M8X21_RS01455	COG3012	SEC-C Motif Domain Protein
M8X21_RS01455	COG1405	negative regulation of cell septum assembly
M8X21_RS01460	COG0667	Aldo Keto reductase
M8X21_RS01470	COG1595	DNA-templated transcription, initiation
M8X21_RS01475	COG1595	DNA-templated transcription, initiation
M8X21_RS01480	COG1876	peptidase activity
M8X21_RS01485	COG0457	Tetratricopeptide repeat
M8X21_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS01495	COG0366	Alpha amylase catalytic
M8X21_RS01500	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8X21_RS01505	COG1121	(ABC) transporter
M8X21_RS01510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8X21_RS01515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS01520	COG2310	stress, protein
M8X21_RS01525	COG2310	stress, protein
M8X21_RS01530	COG2310	stress, protein
M8X21_RS01535	COG0861	Integral membrane protein TerC family
M8X21_RS01545	COG3853	Toxic anion resistance protein (TelA)
M8X21_RS01550	COG0477	Major facilitator Superfamily
M8X21_RS01555	COG0517	IMP dehydrogenase activity
M8X21_RS01555	COG4175	Glycine betaine
M8X21_RS01560	COG4176	ABC-type proline glycine betaine transport system permease component
M8X21_RS01565	COG2113	Glycine betaine
M8X21_RS01570	COG1473	amidohydrolase
M8X21_RS01575	COG1288	antiporter activity
M8X21_RS01585	COG0366	Alpha amylase catalytic
M8X21_RS01595	COG2814	Major facilitator Superfamily
M8X21_RS01600	COG1846	Transcriptional regulator
M8X21_RS01605	COG1280	lysine exporter protein (LysE YggA)
M8X21_RS01610	COG3403	YqcI/YcgG family
M8X21_RS01615	COG1113	amino acid transport
M8X21_RS01620	COG3665	Urea carboxylase-associated protein
M8X21_RS01635	COG1660	Displays ATPase and GTPase activities
M8X21_RS01645	COG2271	Major facilitator Superfamily
M8X21_RS01650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M8X21_RS01655	COG3458	cephalosporin-C deacetylase activity
M8X21_RS01660	COG3541	Predicted nucleotidyltransferase
M8X21_RS01665	COG0506	proline dehydrogenase activity
M8X21_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS01675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8X21_RS01680	COG2508	Transcriptional regulator
M8X21_RS01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8X21_RS01690	COG1587	Uroporphyrinogen-III synthase
M8X21_RS01695	COG2146	nitrite reductase [NAD(P)H] activity
M8X21_RS01700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8X21_RS01705	COG0243	molybdopterin cofactor binding
M8X21_RS01710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8X21_RS01715	COG2223	nitrite transmembrane transporter activity
M8X21_RS01720	COG0523	cobalamin synthesis protein
M8X21_RS01725	COG1063	alcohol dehydrogenase
M8X21_RS01730	COG1714	RDD family
M8X21_RS01740	COG2723	6-phospho-beta-galactosidase activity
M8X21_RS01750	COG3209	COG3209 Rhs family protein
M8X21_RS01755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M8X21_RS01760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M8X21_RS01765	COG1733	regulation of RNA biosynthetic process
M8X21_RS01770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS01795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS01800	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M8X21_RS01815	COG2364	Membrane
M8X21_RS01820	COG1126	abc transporter atp-binding protein
M8X21_RS01825	COG0765	amino acid transport
M8X21_RS01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS01835	COG0583	DNA-binding transcription factor activity
M8X21_RS01840	COG0163	prenyltransferase activity
M8X21_RS01845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M8X21_RS01865	COG3104	oligopeptide transport
M8X21_RS01870	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS01880	COG0697	spore germination
M8X21_RS01890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8X21_RS01895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS01900	COG0456	acetyltransferase
M8X21_RS01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS01910	COG0765	amino acid transport
M8X21_RS01915	COG1126	abc transporter atp-binding protein
M8X21_RS01920	COG1473	amidohydrolase
M8X21_RS01925	COG2079	MmgE PrpD family protein
M8X21_RS01930	COG1136	(ABC) transporter
M8X21_RS01935	COG0577	efflux transmembrane transporter activity
M8X21_RS01940	COG0745	RESPONSE REGULATOR receiver
M8X21_RS01945	COG3850	Histidine kinase
M8X21_RS01945	COG5002	protein histidine kinase activity
M8X21_RS01950	COG0457	Tetratricopeptide repeat
M8X21_RS01965	COG0527	aspartate kinase activity
M8X21_RS01970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS01975	COG4605	iron ion homeostasis
M8X21_RS01980	COG4604	ABC transporter, ATP-binding protein
M8X21_RS01985	COG4607	ABC-type enterochelin transport system periplasmic component
M8X21_RS01990	COG2814	Major facilitator Superfamily
M8X21_RS01995	COG1309	transcriptional regulator
M8X21_RS02000	COG0778	Nitroreductase
M8X21_RS02005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8X21_RS02010	COG0640	Transcriptional regulator
M8X21_RS02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS02020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS02030	COG4975	Glucose uptake
M8X21_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS02040	COG4549	nuclear export factor GLE1
M8X21_RS02045	COG1276	copper resistance
M8X21_RS02045	COG2372	response to copper ion
M8X21_RS02050	COG1349	DNA-binding transcription factor activity
M8X21_RS02060	COG2213	PTS system mannitol-specific
M8X21_RS02065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS02075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M8X21_RS02085	COG0561	phosphatase activity
M8X21_RS02095	COG1914	H( )-stimulated, divalent metal cation uptake system
M8X21_RS02105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8X21_RS02110	COG1984	allophanate hydrolase subunit 2
M8X21_RS02115	COG1414	Transcriptional regulator
M8X21_RS02120	COG2755	lipolytic protein G-D-S-L family
M8X21_RS02130	COG2329	Antibiotic biosynthesis monooxygenase
M8X21_RS02135	COG0768	penicillin binding
M8X21_RS02140	COG4989	oxidoreductase activity
M8X21_RS02145	COG3711	transcriptional antiterminator
M8X21_RS02150	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS02160	COG1917	Cupin 2, conserved barrel domain protein
M8X21_RS02165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8X21_RS02170	COG3871	stress protein (general stress protein 26)
M8X21_RS02180	COG2814	Major facilitator Superfamily
M8X21_RS02185	COG1522	sequence-specific DNA binding
M8X21_RS02190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8X21_RS02190	COG0551	DNA topoisomerase type I activity
M8X21_RS02195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M8X21_RS02200	COG3706	GGDEF domain
M8X21_RS02205	COG5298	Protein conserved in bacteria
M8X21_RS02210	COG1215	transferase activity, transferring glycosyl groups
M8X21_RS02220	COG0531	amino acid
M8X21_RS02225	COG0494	nUDIX hydrolase
M8X21_RS02230	COG0028	Belongs to the TPP enzyme family
M8X21_RS02265	COG1914	H( )-stimulated, divalent metal cation uptake system
M8X21_RS02285	COG2076	Multidrug Resistance protein
M8X21_RS02290	COG2217	Heavy metal translocating P-type atpase
M8X21_RS02295	COG3729	General stress protein
M8X21_RS02300	COG0662	Cupin 2, conserved barrel domain protein
M8X21_RS02305	COG2329	Antibiotic biosynthesis monooxygenase
M8X21_RS02310	COG3546	catalase activity
M8X21_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M8X21_RS02320	COG3290	protein histidine kinase activity
M8X21_RS02325	COG4565	transcriptional regulatory protein
M8X21_RS02330	COG1301	dicarboxylic acid transport
M8X21_RS02335	COG0628	permease
M8X21_RS02340	COG1131	(ABC) transporter
M8X21_RS02345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8X21_RS02355	COG1960	acyl-CoA dehydrogenase activity
M8X21_RS02370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8X21_RS02375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS02385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M8X21_RS02390	COG0513	Belongs to the DEAD box helicase family
M8X21_RS02395	COG3402	PFAM membrane-flanked domain
M8X21_RS02400	COG3428	Bacterial PH domain
M8X21_RS02405	COG0705	Rhomboid family
M8X21_RS02415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M8X21_RS02420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8X21_RS02425	COG0864	Transcriptional regulator
M8X21_RS02430	COG2337	Toxic component of a toxin-antitoxin (TA) module
M8X21_RS02435	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS02440	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS02445	COG2172	sigma factor antagonist activity
M8X21_RS02450	COG2208	phosphoserine phosphatase activity
M8X21_RS02455	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS02465	COG1191	sigma factor activity
M8X21_RS02470	COG2208	phosphoserine phosphatase activity
M8X21_RS02475	COG2183	response to ionizing radiation
M8X21_RS02540	COG1959	2 iron, 2 sulfur cluster binding
M8X21_RS02565	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8X21_RS02595	COG0477	Major facilitator Superfamily
M8X21_RS02610	COG2030	dehydratase
M8X21_RS02625	COG1959	2 iron, 2 sulfur cluster binding
M8X21_RS02630	COG2910	NAD(P)H-binding
M8X21_RS02635	COG1278	Cold shock
M8X21_RS02640	COG1329	Transcriptional regulator
M8X21_RS02645	COG1937	Protein conserved in bacteria
M8X21_RS02650	COG2210	Belongs to the sulfur carrier protein TusA family
M8X21_RS02655	COG1054	Belongs to the UPF0176 family
M8X21_RS02660	COG0425	Belongs to the sulfur carrier protein TusA family
M8X21_RS02660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8X21_RS02670	COG0425	Belongs to the sulfur carrier protein TusA family
M8X21_RS02675	COG0730	response to heat
M8X21_RS02680	COG1794	racemase activity, acting on amino acids and derivatives
M8X21_RS02695	COG3621	Patatin-like phospholipase
M8X21_RS02705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8X21_RS02710	COG1802	Transcriptional regulator
M8X21_RS02715	COG0251	oxidation-reduction process
M8X21_RS02720	COG0814	amino acid
M8X21_RS02725	COG1473	amidohydrolase
M8X21_RS02730	COG2207	Transcriptional regulator
M8X21_RS02730	COG1917	Cupin 2, conserved barrel domain protein
M8X21_RS02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS02745	COG0477	Major facilitator Superfamily
M8X21_RS02785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M8X21_RS02810	COG0351	phosphomethylpyrimidine kinase
M8X21_RS02825	COG1064	alcohol dehydrogenase
M8X21_RS02830	COG0789	Transcriptional regulator
M8X21_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS02855	COG2814	Major facilitator Superfamily
M8X21_RS02860	COG1309	transcriptional regulator
M8X21_RS02865	COG0697	spore germination
M8X21_RS02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS02875	COG5577	PFAM Coat F domain
M8X21_RS02885	COG1063	alcohol dehydrogenase
M8X21_RS02890	COG5577	PFAM Coat F domain
M8X21_RS02900	COG0738	Major facilitator superfamily
M8X21_RS02920	COG4585	Histidine kinase
M8X21_RS02925	COG2197	response regulator
M8X21_RS02930	COG2409	Drug exporters of the RND superfamily
M8X21_RS02935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M8X21_RS02940	COG0488	(ABC) transporter
M8X21_RS02945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8X21_RS02950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS02960	COG2814	Major facilitator Superfamily
M8X21_RS02965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8X21_RS02975	COG0730	response to heat
M8X21_RS02980	COG0456	acetyltransferase
M8X21_RS02985	COG4978	Transcriptional regulator
M8X21_RS02985	COG0789	Transcriptional regulator
M8X21_RS02990	COG0697	spore germination
M8X21_RS02995	COG1051	belongs to the nudix hydrolase family
M8X21_RS03000	COG2226	methyltransferase
M8X21_RS03005	COG0473	3-isopropylmalate dehydrogenase activity
M8X21_RS03010	COG1802	Transcriptional regulator
M8X21_RS03015	COG1819	glycosyl
M8X21_RS03030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8X21_RS03040	COG1388	LysM domain
M8X21_RS03045	COG2814	Major facilitator Superfamily
M8X21_RS03050	COG2188	Transcriptional regulator
M8X21_RS03055	COG2186	Transcriptional regulator
M8X21_RS03060	COG2807	transmembrane transport
M8X21_RS03065	COG2076	Multidrug Resistance protein
M8X21_RS03070	COG2076	Multidrug Resistance protein
M8X21_RS03075	COG1309	transcriptional regulator
M8X21_RS03080	COG0531	amino acid
M8X21_RS03090	COG3832	glyoxalase III activity
M8X21_RS03095	COG0604	alcohol dehydrogenase
M8X21_RS03100	COG2814	Major facilitator Superfamily
M8X21_RS03140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M8X21_RS03145	COG0802	atpase or kinase
M8X21_RS03150	COG1214	PFAM Peptidase M22, glycoprotease
M8X21_RS03155	COG0456	acetyltransferase
M8X21_RS03160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M8X21_RS03165	COG0488	(ABC) transporter
M8X21_RS03180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8X21_RS03185	COG0805	protein transport
M8X21_RS03195	COG1266	CAAX protease self-immunity
M8X21_RS03215	COG0457	Tetratricopeptide repeat
M8X21_RS03220	COG1063	alcohol dehydrogenase
M8X21_RS03225	COG2211	Major facilitator Superfamily
M8X21_RS03230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8X21_RS03240	COG1842	Phage shock protein A
M8X21_RS03245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8X21_RS03250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M8X21_RS03255	COG4260	virion core protein, lumpy skin disease virus
M8X21_RS03260	COG2755	lipolytic protein G-D-S-L family
M8X21_RS03260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M8X21_RS03270	COG1595	DNA-templated transcription, initiation
M8X21_RS03275	COG1063	alcohol dehydrogenase
M8X21_RS03280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8X21_RS03285	COG0823	Involved in the tonB-independent uptake of proteins
M8X21_RS03300	COG2132	Multicopper oxidase
M8X21_RS03305	COG1113	amino acid transport
M8X21_RS03310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8X21_RS03315	COG0714	Associated with various cellular activities
M8X21_RS03320	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M8X21_RS03325	COG1305	Transglutaminase-like
M8X21_RS03335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8X21_RS03355	COG2211	Major facilitator Superfamily
M8X21_RS03370	COG2252	PERMEase
M8X21_RS03375	COG3064	Membrane
M8X21_RS03395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M8X21_RS03400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M8X21_RS03405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M8X21_RS03410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M8X21_RS03415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8X21_RS03430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M8X21_RS03440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M8X21_RS03445	COG0138	bifunctional purine biosynthesis protein purh
M8X21_RS03450	COG0151	Belongs to the GarS family
M8X21_RS03460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M8X21_RS03465	COG1470	cell adhesion involved in biofilm formation
M8X21_RS03470	COG4496	protein, YerC YecD
M8X21_RS03475	COG0069	glutamate synthase activity
M8X21_RS03485	COG0210	DNA helicase
M8X21_RS03495	COG4851	CamS sex pheromone cAM373 precursor
M8X21_RS03500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8X21_RS03505	COG1285	pathogenesis
M8X21_RS03510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8X21_RS03530	COG1309	transcriptional regulator
M8X21_RS03535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8X21_RS03540	COG1597	lipid kinase activity
M8X21_RS03545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8X21_RS03585	COG5444	nuclease activity
M8X21_RS03615	COG3546	catalase activity
M8X21_RS03620	COG0454	-acetyltransferase
M8X21_RS03630	COG2323	membrane
M8X21_RS03635	COG2329	Antibiotic biosynthesis monooxygenase
M8X21_RS03640	COG0346	lactoylglutathione lyase activity
M8X21_RS03645	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS03650	COG5583	Uncharacterized small protein (DUF2292)
M8X21_RS03655	COG0196	riboflavin kinase activity
M8X21_RS03660	COG0670	Belongs to the BI1 family
M8X21_RS03665	COG1846	Transcriptional regulator
M8X21_RS03670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8X21_RS03680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8X21_RS03680	COG2124	cytochrome p450
M8X21_RS03695	COG1131	(ABC) transporter
M8X21_RS03740	COG4106	trans-aconitate 2-methyltransferase activity
M8X21_RS03745	COG1368	sulfuric ester hydrolase activity
M8X21_RS03750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M8X21_RS03755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS03760	COG1442	glycosyl transferase family 8
M8X21_RS03765	COG1216	Glycosyl transferase, family 2
M8X21_RS03770	COG1442	glycosyl transferase family 8
M8X21_RS03775	COG2223	nitrite transmembrane transporter activity
M8X21_RS03780	COG0531	amino acid
M8X21_RS03785	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS03790	COG0840	transmembrane signaling receptor activity
M8X21_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS03800	COG0457	Tetratricopeptide repeat
M8X21_RS03800	COG0463	Glycosyl transferase, family 2
M8X21_RS03805	COG0488	(ABC) transporter
M8X21_RS03810	COG0789	Transcriptional regulator
M8X21_RS03815	COG2814	Major facilitator Superfamily
M8X21_RS03820	COG0488	(ABC) transporter
M8X21_RS03825	COG0513	Belongs to the DEAD box helicase family
M8X21_RS03830	COG0456	acetyltransferase
M8X21_RS03835	COG2130	NADP-dependent
M8X21_RS03850	COG3866	Pectate lyase
M8X21_RS03855	COG0471	metal ion transport
M8X21_RS03885	COG2972	Histidine kinase
M8X21_RS03885	COG0745	RESPONSE REGULATOR receiver
M8X21_RS03895	COG3279	Response regulator of the LytR AlgR family
M8X21_RS03905	COG3764	Sortase (surface protein transpeptidase)
M8X21_RS03910	COG3290	protein histidine kinase activity
M8X21_RS03915	COG4565	transcriptional regulatory protein
M8X21_RS03920	COG3181	Tripartite tricarboxylate transporter family receptor
M8X21_RS03925	COG2851	Citrate transporter
M8X21_RS03930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS03935	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M8X21_RS03945	COG2258	MOSC domain
M8X21_RS03965	COG0024	Methionine aminopeptidase
M8X21_RS03970	COG1263	PTS System
M8X21_RS03970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS03980	COG1368	sulfuric ester hydrolase activity
M8X21_RS03990	COG0071	Belongs to the small heat shock protein (HSP20) family
M8X21_RS04005	COG1263	PTS System
M8X21_RS04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS04010	COG0366	Alpha amylase catalytic
M8X21_RS04015	COG2188	Transcriptional regulator
M8X21_RS04020	COG0778	Nitroreductase
M8X21_RS04035	COG0737	Belongs to the 5'-nucleotidase family
M8X21_RS04040	COG0693	protein deglycase activity
M8X21_RS04045	COG1609	Transcriptional regulator
M8X21_RS04060	COG2814	Major facilitator Superfamily
M8X21_RS04070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8X21_RS04075	COG4980	gas vesicle protein
M8X21_RS04080	COG1295	ribonuclease BN
M8X21_RS04085	COG0477	Major facilitator Superfamily
M8X21_RS04090	COG0387	Pfam Sodium calcium exchanger
M8X21_RS04100	COG0668	transmembrane transport
M8X21_RS04105	COG0535	radical SAM domain protein
M8X21_RS04115	COG0726	polysaccharide deacetylase
M8X21_RS04120	COG2084	Dehydrogenase
M8X21_RS04130	COG0598	Magnesium transport protein CorA
M8X21_RS04135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M8X21_RS04140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8X21_RS04150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8X21_RS04155	COG4637	Psort location Cytoplasmic, score
M8X21_RS04160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8X21_RS04165	COG0022	dehydrogenase e1 component
M8X21_RS04170	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8X21_RS04175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8X21_RS04180	COG3284	Transcriptional regulator
M8X21_RS04190	COG1486	melibiose metabolic process
M8X21_RS04195	COG1737	Transcriptional regulator
M8X21_RS04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS04200	COG1263	PTS System
M8X21_RS04205	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS04210	COG1132	(ABC) transporter
M8X21_RS04215	COG1132	(ABC) transporter
M8X21_RS04220	COG2259	Doxx family
M8X21_RS04225	COG2514	catechol 2,3-dioxygenase activity
M8X21_RS04235	COG1695	Transcriptional regulator
M8X21_RS04240	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8X21_RS04245	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M8X21_RS04250	COG3848	Pyruvate phosphate dikinase
M8X21_RS04250	COG0574	Belongs to the PEP-utilizing enzyme family
M8X21_RS04255	COG2732	(Barnase) inhibitor
M8X21_RS04260	COG2318	DinB family
M8X21_RS04265	COG2814	Major facilitator Superfamily
M8X21_RS04270	COG1846	Transcriptional regulator
M8X21_RS04275	COG0392	lysyltransferase activity
M8X21_RS04275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M8X21_RS04280	COG0384	phenazine biosynthesis protein PhzF
M8X21_RS04285	COG0778	Nitroreductase
M8X21_RS04300	COG1090	epimerase
M8X21_RS04315	COG2814	Major facilitator Superfamily
M8X21_RS04325	COG3591	Belongs to the peptidase S1B family
M8X21_RS04340	COG3103	Sh3 type 3 domain protein
M8X21_RS04345	COG5658	integral membrane protein
M8X21_RS04350	COG0596	Alpha beta hydrolase
M8X21_RS04355	COG0463	Glycosyl transferase, family 2
M8X21_RS04360	COG4485	Bacterial membrane protein, YfhO
M8X21_RS04365	COG1988	membrane-bound metal-dependent
M8X21_RS04370	COG1194	a g-specific adenine glycosylase
M8X21_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS04400	COG1132	(ABC) transporter
M8X21_RS04405	COG4129	membrane
M8X21_RS04415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M8X21_RS04420	COG0735	belongs to the Fur family
M8X21_RS04525	COG4974	Belongs to the 'phage' integrase family
M8X21_RS04595	COG1484	DNA-dependent DNA replication
M8X21_RS04615	COG3655	Transcriptional regulator
M8X21_RS04670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS04670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS04690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M8X21_RS04715	COG1780	Probably involved in ribonucleotide reductase function
M8X21_RS04735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8X21_RS04750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M8X21_RS04760	COG3584	3D domain protein
M8X21_RS04760	COG1388	LysM domain
M8X21_RS04795	COG1595	DNA-templated transcription, initiation
M8X21_RS04810	COG1793	dna ligase
M8X21_RS04865	COG0582	viral genome integration into host DNA
M8X21_RS04945	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8X21_RS04955	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS04980	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS04980	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS05015	COG1757	Na H antiporter
M8X21_RS05020	COG3340	Belongs to the peptidase S51 family
M8X21_RS05030	COG0277	FAD linked oxidase domain protein
M8X21_RS05040	COG0747	negative chemotaxis
M8X21_RS05045	COG0601	transmembrane transport
M8X21_RS05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8X21_RS05055	COG0444	Belongs to the ABC transporter superfamily
M8X21_RS05060	COG4608	Belongs to the ABC transporter superfamily
M8X21_RS05065	COG0753	catalase activity
M8X21_RS05075	COG1116	anion transmembrane transporter activity
M8X21_RS05080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8X21_RS05085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8X21_RS05105	COG1476	TRANSCRIPTIONal
M8X21_RS05115	COG3382	B3 4 domain protein
M8X21_RS05120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8X21_RS05130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M8X21_RS05135	COG0789	Transcriptional regulator
M8X21_RS05140	COG1664	Polymer-forming cytoskeletal
M8X21_RS05145	COG1664	Polymer-forming cytoskeletal
M8X21_RS05150	COG2766	serine protein kinase
M8X21_RS05160	COG1846	Transcriptional regulator
M8X21_RS05165	COG1566	PFAM secretion protein HlyD family protein
M8X21_RS05170	COG2814	Major facilitator Superfamily
M8X21_RS05175	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8X21_RS05190	COG1725	Transcriptional regulator
M8X21_RS05195	COG1131	(ABC) transporter
M8X21_RS05200	COG1131	(ABC) transporter
M8X21_RS05205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8X21_RS05210	COG1278	Cold shock
M8X21_RS05215	COG1464	Belongs to the NlpA lipoprotein family
M8X21_RS05220	COG3706	GGDEF domain
M8X21_RS05225	COG1823	symporter activity
M8X21_RS05245	COG5577	PFAM Coat F domain
M8X21_RS05250	COG1525	nuclease
M8X21_RS05250	COG0737	Belongs to the 5'-nucleotidase family
M8X21_RS05250	COG4085	toxin activity
M8X21_RS05255	COG3764	Sortase (surface protein transpeptidase)
M8X21_RS05260	COG0564	pseudouridine synthase activity
M8X21_RS05270	COG0517	IMP dehydrogenase activity
M8X21_RS05275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8X21_RS05280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8X21_RS05280	COG3153	acetyltransferase
M8X21_RS05285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8X21_RS05290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M8X21_RS05295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M8X21_RS05305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M8X21_RS05310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8X21_RS05315	COG4585	Histidine kinase
M8X21_RS05315	COG2203	Gaf domain
M8X21_RS05320	COG2197	response regulator
M8X21_RS05325	COG0431	NADPH-dependent FMN reductase
M8X21_RS05340	COG0791	NLP P60 protein
M8X21_RS05340	COG1388	LysM domain
M8X21_RS05345	COG1959	2 iron, 2 sulfur cluster binding
M8X21_RS05355	COG2719	SpoVR family
M8X21_RS05360	COG1785	Belongs to the alkaline phosphatase family
M8X21_RS05365	COG1388	LysM domain
M8X21_RS05365	COG0791	NLP P60 protein
M8X21_RS05370	COG0583	DNA-binding transcription factor activity
M8X21_RS05375	COG0372	Belongs to the citrate synthase family
M8X21_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS05385	COG0531	amino acid
M8X21_RS05390	COG0733	neurotransmitter:sodium symporter activity
M8X21_RS05405	COG1595	DNA-templated transcription, initiation
M8X21_RS05410	COG0204	Acyl-transferase
M8X21_RS05415	COG1253	flavin adenine dinucleotide binding
M8X21_RS05420	COG0789	Transcriptional regulator
M8X21_RS05425	COG0436	Aminotransferase
M8X21_RS05430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8X21_RS05435	COG1253	flavin adenine dinucleotide binding
M8X21_RS05440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8X21_RS05445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8X21_RS05450	COG0584	glycerophosphoryl diester phosphodiesterase
M8X21_RS05460	COG0668	transmembrane transport
M8X21_RS05465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M8X21_RS05470	COG0726	polysaccharide deacetylase
M8X21_RS05475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS05480	COG3226	Transcriptional regulator
M8X21_RS05490	COG0589	response to stress
M8X21_RS05495	COG1132	(ABC) transporter
M8X21_RS05500	COG1132	(ABC) transporter
M8X21_RS05505	COG0702	epimerase
M8X21_RS05525	COG0189	ligase activity
M8X21_RS05530	COG0189	ligase activity
M8X21_RS05545	COG4335	DNA alkylation repair
M8X21_RS05550	COG0561	phosphatase activity
M8X21_RS05555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8X21_RS05565	COG0475	glutathione-regulated potassium exporter activity
M8X21_RS05570	COG0490	domain, Protein
M8X21_RS05580	COG1024	Enoyl-CoA hydratase
M8X21_RS05590	COG4152	abc transporter atp-binding protein
M8X21_RS05595	COG1668	transmembrane transport
M8X21_RS05600	COG0420	3'-5' exonuclease activity
M8X21_RS05605	COG4717	serine-type aminopeptidase activity
M8X21_RS05620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8X21_RS05655	COG4980	gas vesicle protein
M8X21_RS05670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M8X21_RS05675	COG0537	adenosine 5'-monophosphoramidase activity
M8X21_RS05680	COG1131	(ABC) transporter
M8X21_RS05685	COG4473	ABC transporter
M8X21_RS05695	COG1473	amidohydrolase
M8X21_RS05700	COG3069	C4-dicarboxylate transmembrane transporter activity
M8X21_RS05705	COG2329	Antibiotic biosynthesis monooxygenase
M8X21_RS05710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8X21_RS05720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M8X21_RS05725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M8X21_RS05730	COG1309	transcriptional regulator
M8X21_RS05735	COG1511	domain protein
M8X21_RS05740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8X21_RS05750	COG1363	Peptidase, m42
M8X21_RS05755	COG1301	dicarboxylic acid transport
M8X21_RS05765	COG1234	tRNA 3'-trailer cleavage
M8X21_RS05770	COG0095	Lipoate-protein ligase
M8X21_RS05775	COG0702	epimerase
M8X21_RS05780	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS05790	COG0501	Belongs to the peptidase M48B family
M8X21_RS05795	COG1404	Belongs to the peptidase S8 family
M8X21_RS05800	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M8X21_RS05805	COG0406	alpha-ribazole phosphatase activity
M8X21_RS05810	COG0183	Belongs to the thiolase family
M8X21_RS05815	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS05820	COG1268	BioY protein
M8X21_RS05825	COG0840	transmembrane signaling receptor activity
M8X21_RS05830	COG0723	plastoquinol--plastocyanin reductase activity
M8X21_RS05830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8X21_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS05845	COG4903	ComK protein
M8X21_RS05855	COG5646	InterPro IPR014922
M8X21_RS05880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8X21_RS05895	COG0398	Pfam SNARE associated Golgi protein
M8X21_RS05900	COG0681	Belongs to the peptidase S26 family
M8X21_RS05905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8X21_RS05910	COG1846	Transcriptional regulator
M8X21_RS05915	COG3180	Ammonia monooxygenase
M8X21_RS05920	COG2814	Major facilitator Superfamily
M8X21_RS05930	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M8X21_RS05935	COG2323	membrane
M8X21_RS05950	COG0420	3'-5' exonuclease activity
M8X21_RS05955	COG0419	ATPase involved in DNA repair
M8X21_RS05960	COG1403	HNH endonuclease
M8X21_RS06000	COG0179	Fumarylacetoacetate (FAA) hydrolase
M8X21_RS06015	COG0367	asparagine synthase
M8X21_RS06020	COG1562	ergosterol biosynthetic process
M8X21_RS06025	COG0534	Mate efflux family protein
M8X21_RS06030	COG1917	Cupin 2, conserved barrel domain protein
M8X21_RS06030	COG2207	Transcriptional regulator
M8X21_RS06035	COG1609	Transcriptional regulator
M8X21_RS06040	COG0673	inositol 2-dehydrogenase activity
M8X21_RS06045	COG2318	DinB family
M8X21_RS06050	COG1357	PFAM Pentapeptide repeats (8 copies)
M8X21_RS06055	COG2153	protein acetylation
M8X21_RS06060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M8X21_RS06060	COG0646	methionine synthase
M8X21_RS06070	COG2996	Protein conserved in bacteria
M8X21_RS06075	COG1744	ABC transporter substrate-binding protein PnrA-like
M8X21_RS06080	COG0840	transmembrane signaling receptor activity
M8X21_RS06085	COG2124	cytochrome p450
M8X21_RS06095	COG1307	EDD domain protein, DegV family
M8X21_RS06100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS06120	COG0561	phosphatase activity
M8X21_RS06125	COG1073	alpha beta
M8X21_RS06130	COG2151	metal-sulfur cluster biosynthetic enzyme
M8X21_RS06140	COG0277	FAD linked oxidase domain protein
M8X21_RS06145	COG2271	Major facilitator Superfamily
M8X21_RS06155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M8X21_RS06165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8X21_RS06170	COG0505	Belongs to the CarA family
M8X21_RS06175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8X21_RS06180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8X21_RS06195	COG2267	carboxylic ester hydrolase activity
M8X21_RS06205	COG1744	ABC transporter substrate-binding protein PnrA-like
M8X21_RS06220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8X21_RS06225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8X21_RS06230	COG5504	Zn-dependent protease
M8X21_RS06235	COG0444	Belongs to the ABC transporter superfamily
M8X21_RS06240	COG4608	Belongs to the ABC transporter superfamily
M8X21_RS06250	COG0601	transmembrane transport
M8X21_RS06255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8X21_RS06265	COG0180	Tryptophanyl-tRNA synthetase
M8X21_RS06270	COG4166	transmembrane transport
M8X21_RS06275	COG0601	transmembrane transport
M8X21_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8X21_RS06285	COG0444	Belongs to the ABC transporter superfamily
M8X21_RS06290	COG4608	Belongs to the ABC transporter superfamily
M8X21_RS06300	COG0456	acetyltransferase
M8X21_RS06305	COG1393	Belongs to the ArsC family
M8X21_RS06310	COG0861	Integral membrane protein TerC family
M8X21_RS06315	COG4862	establishment of competence for transformation
M8X21_RS06320	COG4469	Competence protein
M8X21_RS06325	COG1164	Oligoendopeptidase f
M8X21_RS06335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8X21_RS06340	COG2346	COG2346, Truncated hemoglobins
M8X21_RS06345	COG0741	lytic transglycosylase activity
M8X21_RS06350	COG4116	CYTH
M8X21_RS06360	COG2357	RelA SpoT domain protein
M8X21_RS06365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8X21_RS06370	COG0564	pseudouridine synthase activity
M8X21_RS06380	COG0475	glutathione-regulated potassium exporter activity
M8X21_RS06380	COG0569	domain protein
M8X21_RS06385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M8X21_RS06390	COG0352	thiamine-phosphate diphosphorylase activity
M8X21_RS06395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8X21_RS06400	COG2104	thiamine diphosphate biosynthetic process
M8X21_RS06410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8X21_RS06415	COG0351	phosphomethylpyrimidine kinase
M8X21_RS06420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M8X21_RS06475	COG0210	DNA helicase
M8X21_RS06495	COG1131	(ABC) transporter
M8X21_RS06505	COG2153	protein acetylation
M8X21_RS06515	COG2382	esterase
M8X21_RS06520	COG0626	cystathionine gamma-synthase activity
M8X21_RS06525	COG0626	cystathionine gamma-synthase activity
M8X21_RS06555	COG5444	nuclease activity
M8X21_RS06570	COG0135	phosphoribosylanthranilate isomerase activity
M8X21_RS06625	COG2367	Beta-lactamase
M8X21_RS06630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8X21_RS06635	COG0477	Major facilitator Superfamily
M8X21_RS06640	COG1846	Transcriptional regulator
M8X21_RS06650	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8X21_RS06655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8X21_RS06660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8X21_RS06665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS06665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS06670	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8X21_RS06700	COG1285	pathogenesis
M8X21_RS06715	COG2205	protein histidine kinase activity
M8X21_RS06725	COG3383	formate dehydrogenase (NAD+) activity
M8X21_RS06730	COG2427	Protein of unknown function (DUF1641)
M8X21_RS06735	COG2124	cytochrome p450
M8X21_RS06740	COG1819	glycosyl
M8X21_RS06750	COG1587	Uroporphyrinogen-III synthase
M8X21_RS06755	COG0390	transport system, permease component
M8X21_RS06760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8X21_RS06765	COG0697	spore germination
M8X21_RS06770	COG4297	protein containing double-stranded beta helix domain
M8X21_RS06780	COG1252	NADH dehydrogenase
M8X21_RS06790	COG2211	Major facilitator Superfamily
M8X21_RS06795	COG1609	Transcriptional regulator
M8X21_RS06800	COG0246	Mannitol dehydrogenase
M8X21_RS06805	COG2721	sulfolactate sulfo-lyase activity
M8X21_RS06810	COG0730	response to heat
M8X21_RS06815	COG2318	DinB family
M8X21_RS06820	COG0457	Tetratricopeptide repeat
M8X21_RS06830	COG1388	LysM domain
M8X21_RS06830	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS06830	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS06840	COG4195	phage-related replication protein
M8X21_RS06845	COG3546	catalase activity
M8X21_RS06850	COG2856	Zn peptidase
M8X21_RS06855	COG1396	sequence-specific DNA binding
M8X21_RS06865	COG1522	sequence-specific DNA binding
M8X21_RS06870	COG1484	DNA-dependent DNA replication
M8X21_RS06890	COG1595	DNA-templated transcription, initiation
M8X21_RS06895	COG3728	DNA packaging
M8X21_RS06895	COG5484	DNA packaging
M8X21_RS06900	COG1783	phage Terminase large subunit
M8X21_RS06905	COG5518	Phage portal protein
M8X21_RS06910	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M8X21_RS06915	COG4653	Phage capsid family
M8X21_RS06965	COG5412	phage tail tape measure protein
M8X21_RS06965	COG3953	SLT domain
M8X21_RS06965	COG5412	phage tail tape measure protein
M8X21_RS06965	COG3953	SLT domain
M8X21_RS06965	COG5412	phage tail tape measure protein
M8X21_RS06965	COG3953	SLT domain
M8X21_RS06970	COG1652	LysM domain
M8X21_RS06975	COG4193	domain, Protein
M8X21_RS06985	COG3628	GPW Gp25 family protein
M8X21_RS06990	COG3299	homolog of phage Mu protein gp47
M8X21_RS06995	COG3778	Protein conserved in bacteria
M8X21_RS07035	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS07035	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS07055	COG0306	phosphate transporter
M8X21_RS07060	COG1392	Phosphate transport regulator
M8X21_RS07065	COG0531	amino acid
M8X21_RS07070	COG0346	lactoylglutathione lyase activity
M8X21_RS07075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8X21_RS07080	COG0463	Glycosyl transferase, family 2
M8X21_RS07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8X21_RS07095	COG0477	Major facilitator Superfamily
M8X21_RS07100	COG2362	D-Aminopeptidase
M8X21_RS07105	COG0601	transmembrane transport
M8X21_RS07110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8X21_RS07115	COG0444	Belongs to the ABC transporter superfamily
M8X21_RS07120	COG4166	transmembrane transport
M8X21_RS07125	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8X21_RS07130	COG4948	Mandelate Racemase Muconate Lactonizing
M8X21_RS07135	COG0791	NLP P60 protein
M8X21_RS07140	COG4608	Belongs to the ABC transporter superfamily
M8X21_RS07145	COG2706	6-phosphogluconolactonase activity
M8X21_RS07150	COG1834	amidinotransferase
M8X21_RS07155	COG1607	acyl-coa hydrolase
M8X21_RS07160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8X21_RS07165	COG2076	Multidrug Resistance protein
M8X21_RS07170	COG2076	Multidrug Resistance protein
M8X21_RS07175	COG0788	formyltetrahydrofolate deformylase activity
M8X21_RS07180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8X21_RS07190	COG1764	response to oxidative stress
M8X21_RS07195	COG1846	Transcriptional regulator
M8X21_RS07200	COG1764	response to oxidative stress
M8X21_RS07215	COG0463	Glycosyl transferase, family 2
M8X21_RS07215	COG0457	Tetratricopeptide repeat
M8X21_RS07225	COG2814	Major facilitator Superfamily
M8X21_RS07230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8X21_RS07240	COG1404	Belongs to the peptidase S8 family
M8X21_RS07245	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS07250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8X21_RS07255	COG1122	ATPase activity
M8X21_RS07260	COG4721	ABC-type cobalt transport system, permease component
M8X21_RS07265	COG1388	LysM domain
M8X21_RS07265	COG3858	chitin binding
M8X21_RS07275	COG2239	Acts as a magnesium transporter
M8X21_RS07280	COG0789	Transcriptional regulator
M8X21_RS07295	COG1846	Transcriptional regulator
M8X21_RS07300	COG0726	polysaccharide deacetylase
M8X21_RS07305	COG3285	dna ligase
M8X21_RS07305	COG1793	dna ligase
M8X21_RS07310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M8X21_RS07315	COG0586	Pfam SNARE associated Golgi protein
M8X21_RS07325	COG1191	sigma factor activity
M8X21_RS07350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8X21_RS07355	COG2323	membrane
M8X21_RS07370	COG3594	Acyltransferase
M8X21_RS07375	COG5002	protein histidine kinase activity
M8X21_RS07380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8X21_RS07400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8X21_RS07405	COG0436	Aminotransferase
M8X21_RS07435	COG3852	Histidine kinase
M8X21_RS07440	COG1846	Transcriptional regulator
M8X21_RS07445	COG1360	Flagellar Motor Protein
M8X21_RS07450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8X21_RS07455	COG0542	response to heat
M8X21_RS07460	COG3949	Membrane
M8X21_RS07475	COG0720	synthase
M8X21_RS07480	COG0602	queuosine metabolic process
M8X21_RS07490	COG1733	regulation of RNA biosynthetic process
M8X21_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS07515	COG4873	Protein conserved in bacteria
M8X21_RS07525	COG3773	Cell wall hydrolase
M8X21_RS07530	COG2244	polysaccharide biosynthetic process
M8X21_RS07535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS07540	COG2217	Heavy metal translocating P-type atpase
M8X21_RS07545	COG0006	proline dipeptidase activity
M8X21_RS07550	COG1609	Transcriptional regulator
M8X21_RS07555	COG3711	transcriptional antiterminator
M8X21_RS07560	COG1263	PTS System
M8X21_RS07560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS07560	COG2190	(PTS) system
M8X21_RS07565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS07570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8X21_RS07580	COG1533	DNA photolyase activity
M8X21_RS07585	COG0840	transmembrane signaling receptor activity
M8X21_RS07590	COG2084	Dehydrogenase
M8X21_RS07595	COG2340	Cysteine-rich secretory protein family
M8X21_RS07600	COG0768	penicillin binding
M8X21_RS07605	COG4191	Histidine kinase
M8X21_RS07610	COG0436	Aminotransferase
M8X21_RS07620	COG0784	Response regulator, receiver
M8X21_RS07620	COG0835	chemotaxis
M8X21_RS07630	COG2814	Major facilitator Superfamily
M8X21_RS07635	COG1376	ErfK ybiS ycfS ynhG family protein
M8X21_RS07640	COG1408	metallophosphoesterase
M8X21_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS07655	COG2200	EAL domain
M8X21_RS07660	COG4703	Protein of unknown function (DUF1797)
M8X21_RS07665	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M8X21_RS07675	COG0517	IMP dehydrogenase activity
M8X21_RS07680	COG0583	DNA-binding transcription factor activity
M8X21_RS07685	COG0716	FMN binding
M8X21_RS07695	COG0716	FMN binding
M8X21_RS07715	COG0668	transmembrane transport
M8X21_RS07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS07740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8X21_RS07745	COG0303	'Molybdopterin
M8X21_RS07750	COG1763	Mo-molybdopterin cofactor biosynthetic process
M8X21_RS07755	COG0314	molybdopterin synthase activity
M8X21_RS07760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M8X21_RS07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M8X21_RS07775	COG1136	(ABC) transporter
M8X21_RS07780	COG0577	efflux transmembrane transporter activity
M8X21_RS07785	COG1349	DNA-binding transcription factor activity
M8X21_RS07790	COG1105	Belongs to the carbohydrate kinase PfkB family
M8X21_RS07795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8X21_RS07795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8X21_RS07795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS07800	COG0681	Belongs to the peptidase S26 family
M8X21_RS07810	COG0488	(ABC) transporter
M8X21_RS07815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8X21_RS07820	COG2309	aminopeptidase activity
M8X21_RS07830	COG1077	Cell shape determining protein MreB Mrl
M8X21_RS07835	COG2002	toxin-antitoxin pair type II binding
M8X21_RS07840	COG3852	Histidine kinase
M8X21_RS07845	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M8X21_RS07845	COG2105	PFAM AIG2 family protein
M8X21_RS07850	COG0569	domain protein
M8X21_RS07860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8X21_RS07870	COG0561	phosphatase activity
M8X21_RS07875	COG0242	peptide deformylase activity
M8X21_RS07885	COG0497	DNA recombination
M8X21_RS07895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS07895	COG3321	synthase
M8X21_RS07895	COG4221	oxidoreductase activity
M8X21_RS07900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS07900	COG4221	oxidoreductase activity
M8X21_RS07900	COG3321	synthase
M8X21_RS07900	COG0300	oxidoreductase activity
M8X21_RS07905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS07905	COG3321	synthase
M8X21_RS07905	COG4221	oxidoreductase activity
M8X21_RS07910	COG4221	oxidoreductase activity
M8X21_RS07910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS07910	COG0300	oxidoreductase activity
M8X21_RS07910	COG3321	synthase
M8X21_RS07915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS07915	COG4221	oxidoreductase activity
M8X21_RS07915	COG3321	synthase
M8X21_RS07915	COG0300	oxidoreductase activity
M8X21_RS07920	COG0300	oxidoreductase activity
M8X21_RS07920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS07920	COG4221	oxidoreductase activity
M8X21_RS07920	COG3321	synthase
M8X21_RS07925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS07925	COG3321	synthase
M8X21_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS07925	COG4221	oxidoreductase activity
M8X21_RS07930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8X21_RS07935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8X21_RS07940	COG0022	dehydrogenase e1 component
M8X21_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8X21_RS07950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8X21_RS07955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS07970	COG1982	Orn Lys Arg decarboxylase major
M8X21_RS07990	COG0483	inositol monophosphate 1-phosphatase activity
M8X21_RS08000	COG3227	Zinc metalloprotease (Elastase)
M8X21_RS08005	COG1595	DNA-templated transcription, initiation
M8X21_RS08025	COG1217	gtp-binding protein TYPA
M8X21_RS08035	COG4896	Protein conserved in bacteria
M8X21_RS08045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M8X21_RS08050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8X21_RS08055	COG2066	Belongs to the glutaminase family
M8X21_RS08065	COG0772	Belongs to the SEDS family
M8X21_RS08070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M8X21_RS08085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8X21_RS08085	COG2010	Cytochrome c
M8X21_RS08090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8X21_RS08095	COG1845	cytochrome c oxidase, subunit III
M8X21_RS08100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M8X21_RS08105	COG3336	cytochrome c oxidase
M8X21_RS08115	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M8X21_RS08120	COG2340	Cysteine-rich secretory protein family
M8X21_RS08135	COG3679	Belongs to the UPF0342 family
M8X21_RS08145	COG0742	ribosomal rna small subunit methyltransferase
M8X21_RS08155	COG3314	Sporulation integral membrane protein YlbJ
M8X21_RS08160	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8X21_RS08165	COG3480	Lon protease (S16) C-terminal proteolytic domain
M8X21_RS08180	COG1399	metal-binding, possibly nucleic acid-binding protein
M8X21_RS08200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8X21_RS08220	COG4839	cell division protein FtsL
M8X21_RS08225	COG0768	penicillin binding
M8X21_RS08230	COG0768	penicillin binding
M8X21_RS08250	COG0772	Belongs to the SEDS family
M8X21_RS08265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M8X21_RS08270	COG0849	cell division
M8X21_RS08275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M8X21_RS08280	COG4412	M6 family metalloprotease domain protein
M8X21_RS08280	COG1404	Belongs to the peptidase S8 family
M8X21_RS08290	COG1191	sigma factor activity
M8X21_RS08295	COG1191	sigma factor activity
M8X21_RS08300	COG1119	ATPase activity
M8X21_RS08305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8X21_RS08310	COG1873	PFAM PRC-barrel domain
M8X21_RS08315	COG1496	oxidoreductase activity
M8X21_RS08320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M8X21_RS08330	COG0762	integral membrane protein
M8X21_RS08335	COG2302	S4 RNA-binding domain
M8X21_RS08340	COG3599	regulation of cell shape
M8X21_RS08345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M8X21_RS08350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8X21_RS08360	COG0564	pseudouridine synthase activity
M8X21_RS08370	COG2233	PERMEase
M8X21_RS08380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M8X21_RS08385	COG0505	Belongs to the CarA family
M8X21_RS08390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8X21_RS08405	COG0284	orotidine-5'-phosphate decarboxylase activity
M8X21_RS08410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M8X21_RS08420	COG0306	phosphate transporter
M8X21_RS08435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8X21_RS08440	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M8X21_RS08445	COG1648	precorrin-2 dehydrogenase activity
M8X21_RS08455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M8X21_RS08460	COG1561	YicC-like family, N-terminal region
M8X21_RS08470	COG0194	GDP metabolic process
M8X21_RS08480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8X21_RS08485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8X21_RS08490	COG0242	peptide deformylase activity
M8X21_RS08500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M8X21_RS08500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8X21_RS08510	COG0631	protein serine/threonine phosphatase activity
M8X21_RS08515	COG0515	serine threonine protein kinase
M8X21_RS08515	COG2815	serine threonine protein kinase
M8X21_RS08525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M8X21_RS08530	COG1564	THIamine pyrophosphokinase
M8X21_RS08545	COG1302	Protein conserved in bacteria
M8X21_RS08550	COG1461	Dihydroxyacetone kinase
M8X21_RS08555	COG1760	l-serine dehydratase
M8X21_RS08560	COG1760	l-serine dehydratase
M8X21_RS08565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M8X21_RS08580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8X21_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS08600	COG1196	nuclear chromosome segregation
M8X21_RS08605	COG0552	protein localization to endoplasmic reticulum
M8X21_RS08620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M8X21_RS08630	COG1837	Belongs to the UPF0109 family
M8X21_RS08655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8X21_RS08670	COG2257	FlhB HrpN YscU SpaS Family
M8X21_RS08680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M8X21_RS08685	COG0758	DNA mediated transformation
M8X21_RS08690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8X21_RS08700	COG4974	Belongs to the 'phage' integrase family
M8X21_RS08720	COG1815	bacterial-type flagellum-dependent cell motility
M8X21_RS08725	COG1558	bacterial-type flagellum-dependent cell motility
M8X21_RS08730	COG1677	Flagellar hook-basal body complex protein FliE
M8X21_RS08735	COG1766	The M ring may be actively involved in energy transduction
M8X21_RS08740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8X21_RS08745	COG1317	bacterial-type flagellum organization
M8X21_RS08750	COG1157	protein secretion by the type III secretion system
M8X21_RS08755	COG2882	bacterial-type flagellum organization
M8X21_RS08760	COG3334	PFAM MgtE intracellular
M8X21_RS08765	COG3144	bacterial-type flagellum assembly
M8X21_RS08770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M8X21_RS08775	COG4786	Flagellar basal body rod
M8X21_RS08780	COG1582	Flagellar protein (FlbD)
M8X21_RS08785	COG1580	Controls the rotational direction of flagella during chemotaxis
M8X21_RS08790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8X21_RS08795	COG1776	CheC inhibitor of MCP methylation
M8X21_RS08795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8X21_RS08800	COG2201	protein-glutamate methylesterase activity
M8X21_RS08805	COG3190	flagellar
M8X21_RS08810	COG1338	Plays a role in the flagellum-specific transport system
M8X21_RS08815	COG1987	bacterial-type flagellum assembly
M8X21_RS08820	COG1684	flagellar biosynthetic protein fliR
M8X21_RS08825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8X21_RS08830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8X21_RS08835	COG1419	protein localization to endoplasmic reticulum
M8X21_RS08840	COG0455	bacterial-type flagellum organization
M8X21_RS08845	COG2201	protein-glutamate methylesterase activity
M8X21_RS08850	COG0643	Histidine kinase
M8X21_RS08850	COG2198	Histidine kinase
M8X21_RS08855	COG0835	chemotaxis
M8X21_RS08860	COG1776	CheC inhibitor of MCP methylation
M8X21_RS08870	COG1191	sigma factor activity
M8X21_RS08900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M8X21_RS08905	COG4589	Belongs to the CDS family
M8X21_RS08915	COG0750	zinc metalloprotease
M8X21_RS08925	COG2176	DNA-directed DNA polymerase activity
M8X21_RS08935	COG0195	Participates in both transcription termination and antitermination
M8X21_RS08940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M8X21_RS08945	COG1358	cellular component organization or biogenesis
M8X21_RS08955	COG1550	Protein conserved in bacteria
M8X21_RS08970	COG0196	riboflavin kinase activity
M8X21_RS08985	COG0726	polysaccharide deacetylase
M8X21_RS08990	COG0612	Peptidase, M16
M8X21_RS08995	COG1873	PFAM PRC-barrel domain
M8X21_RS09000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8X21_RS09005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8X21_RS09010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M8X21_RS09015	COG0527	aspartate kinase activity
M8X21_RS09025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8X21_RS09030	COG0740	serine-type endopeptidase activity
M8X21_RS09040	COG4980	gas vesicle protein
M8X21_RS09040	COG1674	ftsk spoiiie
M8X21_RS09045	COG2188	Transcriptional regulator
M8X21_RS09050	COG2814	Major facilitator Superfamily
M8X21_RS09055	COG1846	Transcriptional regulator
M8X21_RS09060	COG1033	growth of symbiont in host cell
M8X21_RS09060	COG2409	Drug exporters of the RND superfamily
M8X21_RS09065	COG0612	Peptidase, M16
M8X21_RS09070	COG0612	Peptidase, M16
M8X21_RS09075	COG0300	oxidoreductase activity
M8X21_RS09090	COG1426	Protein conserved in bacteria
M8X21_RS09095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M8X21_RS09110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8X21_RS09120	COG1692	metallophosphoesterase
M8X21_RS09125	COG2359	stage V sporulation protein S
M8X21_RS09145	COG4550	Control of competence regulator ComK, YlbF/YmcA
M8X21_RS09165	COG0582	viral genome integration into host DNA
M8X21_RS09195	COG5444	nuclease activity
M8X21_RS09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS09230	COG3425	synthase
M8X21_RS09235	COG1024	Enoyl-CoA hydratase
M8X21_RS09240	COG1024	Enoyl-CoA hydratase
M8X21_RS09245	COG0300	oxidoreductase activity
M8X21_RS09245	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS09245	COG3321	synthase
M8X21_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09250	COG4221	oxidoreductase activity
M8X21_RS09250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS09250	COG0300	oxidoreductase activity
M8X21_RS09250	COG3321	synthase
M8X21_RS09255	COG3321	synthase
M8X21_RS09255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS09255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09255	COG3321	synthase
M8X21_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS09260	COG3321	synthase
M8X21_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09260	COG4221	oxidoreductase activity
M8X21_RS09265	COG3321	synthase
M8X21_RS09265	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8X21_RS09265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M8X21_RS09265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS09270	COG2124	cytochrome p450
M8X21_RS09275	COG3209	COG3209 Rhs family protein
M8X21_RS09280	COG3619	membrane
M8X21_RS09290	COG1404	Belongs to the peptidase S8 family
M8X21_RS09300	COG4195	phage-related replication protein
M8X21_RS09305	COG1764	response to oxidative stress
M8X21_RS09315	COG2076	Multidrug Resistance protein
M8X21_RS09355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8X21_RS09360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8X21_RS09370	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS09375	COG0464	growth
M8X21_RS09380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M8X21_RS09385	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M8X21_RS09390	COG0789	Transcriptional regulator
M8X21_RS09395	COG0174	glutamine synthetase
M8X21_RS09415	COG2211	Major facilitator Superfamily
M8X21_RS09420	COG3507	Belongs to the glycosyl hydrolase 43 family
M8X21_RS09435	COG1070	Carbohydrate kinase
M8X21_RS09440	COG0574	Belongs to the PEP-utilizing enzyme family
M8X21_RS09440	COG3848	Pyruvate phosphate dikinase
M8X21_RS09460	COG2378	regulation of single-species biofilm formation
M8X21_RS09465	COG2318	DinB family
M8X21_RS09470	COG1064	alcohol dehydrogenase
M8X21_RS09495	COG0456	acetyltransferase
M8X21_RS09500	COG5444	nuclease activity
M8X21_RS09530	COG0243	molybdopterin cofactor binding
M8X21_RS09535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8X21_RS09540	COG1070	Carbohydrate kinase
M8X21_RS09545	COG2814	Major facilitator Superfamily
M8X21_RS09555	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8X21_RS09560	COG0300	oxidoreductase activity
M8X21_RS09575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8X21_RS09580	COG0583	DNA-binding transcription factor activity
M8X21_RS09585	COG0067	glutamate synthase
M8X21_RS09585	COG0069	glutamate synthase activity
M8X21_RS09585	COG0070	glutamate synthase
M8X21_RS09590	COG0493	'glutamate synthase
M8X21_RS09600	COG0604	alcohol dehydrogenase
M8X21_RS09610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M8X21_RS09615	COG0640	Transcriptional regulator
M8X21_RS09620	COG2814	Major facilitator Superfamily
M8X21_RS09625	COG0405	Gamma-glutamyltransferase
M8X21_RS09630	COG0166	Belongs to the GPI family
M8X21_RS09635	COG0582	viral genome integration into host DNA
M8X21_RS09650	COG0534	Mate efflux family protein
M8X21_RS09655	COG2017	converts alpha-aldose to the beta-anomer
M8X21_RS09660	COG2027	D-alanyl-D-alanine carboxypeptidase
M8X21_RS09665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS09685	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8X21_RS09695	COG1649	PFAM Uncharacterised BCR, COG1649
M8X21_RS09700	COG1960	acyl-CoA dehydrogenase activity
M8X21_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS09710	COG0439	Biotin carboxylase
M8X21_RS09715	COG0511	ligase activity, forming carbon-carbon bonds
M8X21_RS09720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M8X21_RS09725	COG1024	Enoyl-CoA hydratase
M8X21_RS09730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8X21_RS09735	COG0586	Pfam SNARE associated Golgi protein
M8X21_RS09740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8X21_RS09745	COG2246	polysaccharide biosynthetic process
M8X21_RS09755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8X21_RS09775	COG2124	cytochrome p450
M8X21_RS09780	COG2610	gluconate transmembrane transporter activity
M8X21_RS09785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8X21_RS09790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8X21_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09820	COG3507	Belongs to the glycosyl hydrolase 43 family
M8X21_RS09830	COG0745	RESPONSE REGULATOR receiver
M8X21_RS09835	COG2205	protein histidine kinase activity
M8X21_RS09860	COG0577	efflux transmembrane transporter activity
M8X21_RS09860	COG1136	(ABC) transporter
M8X21_RS09885	COG2271	Major facilitator Superfamily
M8X21_RS09890	COG1609	Transcriptional regulator
M8X21_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS09900	COG1312	Catalyzes the dehydration of D-mannonate
M8X21_RS09905	COG0800	Aldolase
M8X21_RS09910	COG1063	alcohol dehydrogenase
M8X21_RS09920	COG1115	amino acid carrier protein
M8X21_RS09930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8X21_RS09935	COG0187	DNA topoisomerase II activity
M8X21_RS09940	COG1832	CoA-binding protein
M8X21_RS09950	COG4841	protein insertion into membrane
M8X21_RS09960	COG0824	Thioesterase
M8X21_RS09980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS09985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M8X21_RS10000	COG0071	Belongs to the small heat shock protein (HSP20) family
M8X21_RS10010	COG4846	Membrane protein involved in cytochrome C biogenesis
M8X21_RS10015	COG2201	protein-glutamate methylesterase activity
M8X21_RS10020	COG0785	Cytochrome C biogenesis protein
M8X21_RS10040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M8X21_RS10050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M8X21_RS10085	COG4195	phage-related replication protein
M8X21_RS10090	COG0756	dUTP diphosphatase activity
M8X21_RS10095	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS10115	COG3397	chitin binding
M8X21_RS10160	COG5444	nuclease activity
M8X21_RS10165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8X21_RS10170	COG0662	Cupin 2, conserved barrel domain protein
M8X21_RS10170	COG2207	Transcriptional regulator
M8X21_RS10175	COG1309	transcriptional regulator
M8X21_RS10180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS10190	COG0640	Transcriptional regulator
M8X21_RS10195	COG0741	lytic transglycosylase activity
M8X21_RS10200	COG2322	membrane
M8X21_RS10215	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8X21_RS10225	COG3584	3D domain protein
M8X21_RS10225	COG1388	LysM domain
M8X21_RS10230	COG0514	ATP-dependent DNA helicase (RecQ)
M8X21_RS10240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M8X21_RS10245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8X21_RS10260	COG0071	Belongs to the small heat shock protein (HSP20) family
M8X21_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS10295	COG1657	PFAM Prenyltransferase squalene oxidase
M8X21_RS10300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8X21_RS10305	COG0733	neurotransmitter:sodium symporter activity
M8X21_RS10310	COG0385	Bile acid
M8X21_RS10315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS10320	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8X21_RS10330	COG4548	von Willebrand factor, type A
M8X21_RS10335	COG0714	Associated with various cellular activities
M8X21_RS10340	COG2032	superoxide dismutase activity
M8X21_RS10345	COG0791	NLP P60 protein
M8X21_RS10345	COG1388	LysM domain
M8X21_RS10350	COG1819	glycosyl
M8X21_RS10355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8X21_RS10360	COG0534	Mate efflux family protein
M8X21_RS10365	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS10370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8X21_RS10375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8X21_RS10385	COG2962	Rard protein
M8X21_RS10400	COG1942	4-Oxalocrotonate Tautomerase
M8X21_RS10410	COG1733	regulation of RNA biosynthetic process
M8X21_RS10415	COG0778	Nitroreductase
M8X21_RS10420	COG0400	carboxylic ester hydrolase activity
M8X21_RS10425	COG0346	lactoylglutathione lyase activity
M8X21_RS10435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8X21_RS10445	COG2723	6-phospho-beta-galactosidase activity
M8X21_RS10450	COG2188	Transcriptional regulator
M8X21_RS10455	COG0793	Belongs to the peptidase S41A family
M8X21_RS10455	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS10460	COG2226	methyltransferase
M8X21_RS10470	COG1876	peptidase activity
M8X21_RS10495	COG0671	phosphoesterase, PA-phosphatase related
M8X21_RS10525	COG1509	lysine 2,3-aminomutase activity
M8X21_RS10530	COG0456	acetyltransferase
M8X21_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8X21_RS10540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8X21_RS10545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8X21_RS10550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8X21_RS10555	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M8X21_RS10565	COG0456	acetyltransferase
M8X21_RS10570	COG0463	Glycosyl transferase, family 2
M8X21_RS10585	COG4641	Protein conserved in bacteria
M8X21_RS10595	COG1086	Polysaccharide biosynthesis protein
M8X21_RS10620	COG1388	LysM domain
M8X21_RS10625	COG0457	Tetratricopeptide repeat
M8X21_RS10660	COG3655	Transcriptional regulator
M8X21_RS10690	COG0457	Tetratricopeptide repeat
M8X21_RS10715	COG2197	response regulator
M8X21_RS10720	COG4585	Histidine kinase
M8X21_RS10725	COG0730	response to heat
M8X21_RS10750	COG5444	nuclease activity
M8X21_RS10760	COG1525	nuclease
M8X21_RS10795	COG1846	Transcriptional regulator
M8X21_RS10800	COG4698	Protein conserved in bacteria
M8X21_RS10805	COG2755	lipolytic protein G-D-S-L family
M8X21_RS10810	COG1999	signal sequence binding
M8X21_RS10820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8X21_RS10825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M8X21_RS10830	COG1272	protein, Hemolysin III
M8X21_RS10840	COG0204	Acyl-transferase
M8X21_RS10845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8X21_RS10860	COG2521	methyltransferase
M8X21_RS10860	COG2136	Putative SAM-dependent methyltransferase
M8X21_RS10875	COG1413	lyase activity
M8X21_RS10880	COG1418	mRNA catabolic process
M8X21_RS10885	COG0386	Belongs to the glutathione peroxidase family
M8X21_RS10895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8X21_RS10905	COG1278	Cold shock
M8X21_RS10925	COG0328	RNA-DNA hybrid ribonuclease activity
M8X21_RS10930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M8X21_RS10935	COG0328	RNA-DNA hybrid ribonuclease activity
M8X21_RS10945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS10960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8X21_RS10970	COG1755	Isoprenylcysteine carboxyl methyltransferase
M8X21_RS10975	COG3424	synthase
M8X21_RS10995	COG1335	isochorismatase
M8X21_RS11000	COG2233	PERMEase
M8X21_RS11010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M8X21_RS11015	COG1199	ATP-dependent helicase activity
M8X21_RS11030	COG0116	Belongs to the methyltransferase superfamily
M8X21_RS11060	COG3359	exonuclease
M8X21_RS11065	COG1205	dead DEAH box helicase
M8X21_RS11065	COG1111	helicase
M8X21_RS11070	COG2190	(PTS) system
M8X21_RS11075	COG0071	Belongs to the small heat shock protein (HSP20) family
M8X21_RS11115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8X21_RS11115	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8X21_RS11125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8X21_RS11130	COG3935	DnaD domain protein
M8X21_RS11140	COG0436	Aminotransferase
M8X21_RS11145	COG5353	protein conserved in bacteria
M8X21_RS11155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M8X21_RS11155	COG1199	ATP-dependent helicase activity
M8X21_RS11185	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS11190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8X21_RS11205	COG1694	Mazg nucleotide pyrophosphohydrolase
M8X21_RS11210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS11215	COG2140	Oxalate decarboxylase
M8X21_RS11225	COG4347	Protein of unknown function (DUF1405)
M8X21_RS11230	COG2010	Cytochrome c
M8X21_RS11230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8X21_RS11235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8X21_RS11240	COG0723	plastoquinol--plastocyanin reductase activity
M8X21_RS11255	COG0457	Tetratricopeptide repeat
M8X21_RS11265	COG0287	Prephenate dehydrogenase
M8X21_RS11300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8X21_RS11305	COG4401	Chorismate mutase type I
M8X21_RS11320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M8X21_RS11325	COG0105	UTP biosynthetic process
M8X21_RS11330	COG0142	geranyltranstransferase activity
M8X21_RS11340	COG0142	geranyltranstransferase activity
M8X21_RS11355	COG0776	regulation of translation
M8X21_RS11360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8X21_RS11400	COG0539	negative regulation of cytoplasmic translation
M8X21_RS11415	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M8X21_RS11420	COG2959	enzyme of heme biosynthesis
M8X21_RS11425	COG3773	Cell wall hydrolase
M8X21_RS11425	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS11430	COG2339	peptidase activity
M8X21_RS11435	COG0492	ferredoxin-NADP+ reductase activity
M8X21_RS11440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8X21_RS11445	COG4862	establishment of competence for transformation
M8X21_RS11450	COG1408	metallophosphoesterase
M8X21_RS11460	COG1388	LysM domain
M8X21_RS11465	COG1266	CAAX protease self-immunity
M8X21_RS11470	COG0514	ATP-dependent DNA helicase (RecQ)
M8X21_RS11475	COG4955	Helix-turn-helix domain
M8X21_RS11480	COG1141	Ferredoxin
M8X21_RS11485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M8X21_RS11490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8X21_RS11500	COG1595	DNA-templated transcription, initiation
M8X21_RS11505	COG5002	protein histidine kinase activity
M8X21_RS11510	COG0745	RESPONSE REGULATOR receiver
M8X21_RS11515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8X21_RS11520	COG1333	cytochrome c biogenesis protein
M8X21_RS11525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS11530	COG1187	pseudouridine synthase activity
M8X21_RS11535	COG0700	Nucleoside recognition
M8X21_RS11540	COG2715	membrane protein required for spore maturation
M8X21_RS11545	COG1686	Belongs to the peptidase S11 family
M8X21_RS11570	COG1547	Domain of unknown function (DUF309)
M8X21_RS11575	COG0456	acetyltransferase
M8X21_RS11590	COG0307	riboflavin synthase, alpha
M8X21_RS11595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8X21_RS11595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8X21_RS11605	COG0681	Belongs to the peptidase S26 family
M8X21_RS11615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M8X21_RS11620	COG4086	secreted protein
M8X21_RS11625	COG0019	diaminopimelate decarboxylase activity
M8X21_RS11630	COG0697	spore germination
M8X21_RS11645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8X21_RS11665	COG1191	sigma factor activity
M8X21_RS11675	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS11680	COG1686	Belongs to the peptidase S11 family
M8X21_RS11685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M8X21_RS11690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M8X21_RS11695	COG4974	Belongs to the 'phage' integrase family
M8X21_RS11705	COG0735	belongs to the Fur family
M8X21_RS11710	COG1300	Membrane
M8X21_RS11725	COG0281	malic enzyme
M8X21_RS11730	COG1757	Na H antiporter
M8X21_RS11735	COG1027	Aspartate ammonia-lyase
M8X21_RS11740	COG0252	asparaginase activity
M8X21_RS11745	COG1396	sequence-specific DNA binding
M8X21_RS11750	COG1379	DNA repair
M8X21_RS11755	COG0494	nUDIX hydrolase
M8X21_RS11765	COG0667	Aldo Keto reductase
M8X21_RS11775	COG1073	alpha beta
M8X21_RS11785	COG4918	Iron-sulphur cluster biosynthesis
M8X21_RS11790	COG0456	acetyltransferase
M8X21_RS11790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M8X21_RS11795	COG2329	Antibiotic biosynthesis monooxygenase
M8X21_RS11800	COG0456	acetyltransferase
M8X21_RS11805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8X21_RS11820	COG0628	permease
M8X21_RS11830	COG0346	lactoylglutathione lyase activity
M8X21_RS11840	COG3048	D-serine ammonia-lyase activity
M8X21_RS11845	COG0300	oxidoreductase activity
M8X21_RS11850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS11855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8X21_RS11860	COG1024	Enoyl-CoA hydratase
M8X21_RS11865	COG3425	synthase
M8X21_RS11870	COG2124	cytochrome p450
M8X21_RS11875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS11875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS11875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11875	COG3321	synthase
M8X21_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11880	COG3321	synthase
M8X21_RS11880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS11880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS11885	COG3321	synthase
M8X21_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11885	COG0300	oxidoreductase activity
M8X21_RS11885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11890	COG0300	oxidoreductase activity
M8X21_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS11890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11890	COG3321	synthase
M8X21_RS11895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS11895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS11895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11895	COG3321	synthase
M8X21_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11900	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS11900	COG0300	oxidoreductase activity
M8X21_RS11900	COG3321	synthase
M8X21_RS11905	COG3321	synthase
M8X21_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8X21_RS11905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8X21_RS11905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS11915	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS11930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8X21_RS11930	COG2070	2-Nitropropane dioxygenase
M8X21_RS11935	COG0250	Participates in transcription elongation, termination and antitermination
M8X21_RS11960	COG0596	Alpha beta hydrolase
M8X21_RS11975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M8X21_RS11980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M8X21_RS11995	COG0706	membrane insertase activity
M8X21_RS12000	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8X21_RS12005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8X21_RS12010	COG0346	lactoylglutathione lyase activity
M8X21_RS12020	COG1376	ErfK ybiS ycfS ynhG family protein
M8X21_RS12025	COG4129	membrane
M8X21_RS12030	COG1126	abc transporter atp-binding protein
M8X21_RS12035	COG0765	amino acid transport
M8X21_RS12040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS12050	COG1597	lipid kinase activity
M8X21_RS12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8X21_RS12060	COG0022	dehydrogenase e1 component
M8X21_RS12065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8X21_RS12070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8X21_RS12075	COG3426	butyrate kinase activity
M8X21_RS12080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8X21_RS12085	COG0280	phosphate acetyltransferase
M8X21_RS12090	COG3829	transcription factor binding
M8X21_RS12090	COG3290	protein histidine kinase activity
M8X21_RS12100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M8X21_RS12105	COG2079	MmgE PrpD family protein
M8X21_RS12110	COG0372	Belongs to the citrate synthase family
M8X21_RS12115	COG1960	acyl-CoA dehydrogenase activity
M8X21_RS12120	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8X21_RS12125	COG0183	Belongs to the thiolase family
M8X21_RS12130	COG0584	glycerophosphoryl diester phosphodiesterase
M8X21_RS12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS12160	COG1902	pentaerythritol trinitrate reductase activity
M8X21_RS12175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8X21_RS12180	COG0745	RESPONSE REGULATOR receiver
M8X21_RS12185	COG0750	zinc metalloprotease
M8X21_RS12190	COG0497	DNA recombination
M8X21_RS12200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M8X21_RS12210	COG0142	geranyltranstransferase activity
M8X21_RS12220	COG1570	exodeoxyribonuclease VII activity
M8X21_RS12235	COG1302	Protein conserved in bacteria
M8X21_RS12240	COG0439	Biotin carboxylase
M8X21_RS12245	COG0511	ligase activity, forming carbon-carbon bonds
M8X21_RS12285	COG3854	ATPases associated with a variety of cellular activities
M8X21_RS12300	COG0006	proline dipeptidase activity
M8X21_RS12310	COG3872	metal-dependent enzyme
M8X21_RS12320	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8X21_RS12335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8X21_RS12355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8X21_RS12370	COG1396	sequence-specific DNA binding
M8X21_RS12380	COG0681	Belongs to the peptidase S26 family
M8X21_RS12405	COG4940	Competence protein ComGF
M8X21_RS12415	COG4970	Tfp pilus assembly protein FimT
M8X21_RS12420	COG4537	Required for transformation and DNA binding
M8X21_RS12425	COG1459	type II secretion system
M8X21_RS12430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M8X21_RS12435	COG0598	Magnesium transport protein CorA
M8X21_RS12440	COG1253	flavin adenine dinucleotide binding
M8X21_RS12445	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS12455	COG1393	Belongs to the ArsC family
M8X21_RS12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS12475	COG0011	TIGRFAM Protein of
M8X21_RS12485	COG2866	Carboxypeptidase
M8X21_RS12490	COG1940	carbohydrate kinase activity
M8X21_RS12495	COG4483	Protein conserved in bacteria
M8X21_RS12500	COG1757	Na H antiporter
M8X21_RS12510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M8X21_RS12525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8X21_RS12530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8X21_RS12535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8X21_RS12540	COG0581	inorganic phosphate transmembrane transporter activity
M8X21_RS12545	COG0573	inorganic phosphate transmembrane transporter activity
M8X21_RS12550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M8X21_RS12555	COG0768	penicillin binding
M8X21_RS12560	COG0477	Major facilitator Superfamily
M8X21_RS12565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8X21_RS12570	COG2839	Protein conserved in bacteria
M8X21_RS12575	COG5521	maltodextrose utilization protein MalA
M8X21_RS12580	COG1388	LysM domain
M8X21_RS12595	COG4709	membrane
M8X21_RS12600	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M8X21_RS12605	COG0735	belongs to the Fur family
M8X21_RS12610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS12625	COG0513	Belongs to the DEAD box helicase family
M8X21_RS12640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M8X21_RS12645	COG2384	SAM-dependent methyltransferase
M8X21_RS12650	COG2010	Cytochrome c
M8X21_RS12655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M8X21_RS12660	COG0358	DNA primase activity
M8X21_RS12675	COG0517	IMP dehydrogenase activity
M8X21_RS12680	COG0751	glycine-tRNA ligase activity
M8X21_RS12700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M8X21_RS12705	COG0295	cytidine deaminase activity
M8X21_RS12710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M8X21_RS12720	COG1480	7TM receptor with intracellular HD hydrolase
M8X21_RS12725	COG1702	phosphate starvation-inducible protein PhoH
M8X21_RS12730	COG0561	phosphatase activity
M8X21_RS12745	COG4864	UPF0365 protein
M8X21_RS12750	COG1030	water channel activity
M8X21_RS12755	COG1610	YqeY-like protein
M8X21_RS12765	COG1283	sodium-dependent phosphate transmembrane transporter activity
M8X21_RS12770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8X21_RS12775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M8X21_RS12805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8X21_RS12820	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS12850	COG0658	competence protein
M8X21_RS12850	COG2333	competence protein COMEC
M8X21_RS12855	COG2131	deaminase
M8X21_RS12860	COG1555	photosystem II stabilization
M8X21_RS12860	COG1596	polysaccharide export
M8X21_RS12865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8X21_RS12870	COG2226	methyltransferase
M8X21_RS12875	COG0799	negative regulation of ribosome biogenesis
M8X21_RS12880	COG1713	HD superfamily hydrolase involved in NAD metabolism
M8X21_RS12890	COG1534	Rna-binding protein
M8X21_RS12895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M8X21_RS12900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8X21_RS12905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M8X21_RS12915	COG2755	lipolytic protein G-D-S-L family
M8X21_RS12925	COG0398	Pfam SNARE associated Golgi protein
M8X21_RS12960	COG5444	nuclease activity
M8X21_RS12965	COG4282	regulation of fungal-type cell wall biogenesis
M8X21_RS12980	COG2207	Transcriptional regulator
M8X21_RS12980	COG3708	Transcriptional regulator
M8X21_RS12985	COG0583	DNA-binding transcription factor activity
M8X21_RS13000	COG5002	protein histidine kinase activity
M8X21_RS13000	COG0642	Histidine kinase
M8X21_RS13005	COG0745	RESPONSE REGULATOR receiver
M8X21_RS13010	COG2311	Membrane
M8X21_RS13020	COG0454	-acetyltransferase
M8X21_RS13025	COG0563	adenylate kinase activity
M8X21_RS13035	COG2814	Major facilitator Superfamily
M8X21_RS13050	COG5444	nuclease activity
M8X21_RS13080	COG0456	acetyltransferase
M8X21_RS13085	COG2318	DinB family
M8X21_RS13095	COG0561	phosphatase activity
M8X21_RS13100	COG0561	phosphatase activity
M8X21_RS13110	COG1482	cell wall glycoprotein biosynthetic process
M8X21_RS13115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8X21_RS13115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8X21_RS13115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS13120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS13120	COG3711	transcriptional antiterminator
M8X21_RS13130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M8X21_RS13135	COG0583	DNA-binding transcription factor activity
M8X21_RS13140	COG2814	Major facilitator Superfamily
M8X21_RS13145	COG2124	cytochrome p450
M8X21_RS13145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8X21_RS13150	COG1309	transcriptional regulator
M8X21_RS13155	COG2226	methyltransferase
M8X21_RS13170	COG2116	formate transmembrane transporter activity
M8X21_RS13175	COG5609	conserved protein (DUF2294)
M8X21_RS13180	COG3383	formate dehydrogenase (NAD+) activity
M8X21_RS13185	COG2427	Protein of unknown function (DUF1641)
M8X21_RS13195	COG0626	cystathionine gamma-synthase activity
M8X21_RS13200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8X21_RS13225	COG0768	penicillin binding
M8X21_RS13240	COG0826	peptidase U32
M8X21_RS13245	COG0826	peptidase U32
M8X21_RS13250	COG4122	O-methyltransferase activity
M8X21_RS13255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8X21_RS13270	COG4472	Bacterial protein of unknown function (DUF965)
M8X21_RS13280	COG0628	permease
M8X21_RS13285	COG1126	abc transporter atp-binding protein
M8X21_RS13290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS13295	COG0765	amino acid transport
M8X21_RS13300	COG0765	amino acid transport
M8X21_RS13315	COG3881	PFAM PRC-barrel domain
M8X21_RS13320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M8X21_RS13325	COG0457	Tetratricopeptide repeat
M8X21_RS13335	COG1104	cysteine desulfurase activity
M8X21_RS13340	COG1959	2 iron, 2 sulfur cluster binding
M8X21_RS13345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8X21_RS13350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M8X21_RS13375	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS13375	COG3103	Sh3 type 3 domain protein
M8X21_RS13375	COG4991	sh3 domain protein
M8X21_RS13385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M8X21_RS13395	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M8X21_RS13395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M8X21_RS13400	COG5416	Lipopolysaccharide assembly protein A domain
M8X21_RS13405	COG0490	domain, Protein
M8X21_RS13410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8X21_RS13410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8X21_RS13420	COG2244	polysaccharide biosynthetic process
M8X21_RS13425	COG2323	membrane
M8X21_RS13435	COG1862	Preprotein translocase
M8X21_RS13475	COG1388	LysM domain
M8X21_RS13485	COG0157	Belongs to the NadC ModD family
M8X21_RS13490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M8X21_RS13495	COG1104	cysteine desulfurase activity
M8X21_RS13500	COG1827	regulation of RNA biosynthetic process
M8X21_RS13505	COG0077	Prephenate dehydratase
M8X21_RS13520	COG3290	protein histidine kinase activity
M8X21_RS13525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M8X21_RS13530	COG2868	ribosomal protein
M8X21_RS13540	COG1994	Peptidase M50
M8X21_RS13545	COG0739	heme binding
M8X21_RS13550	COG2894	cell division
M8X21_RS13560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M8X21_RS13570	COG1077	Cell shape determining protein MreB Mrl
M8X21_RS13590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M8X21_RS13595	COG0285	dihydrofolate synthase activity
M8X21_RS13600	COG0525	valine-tRNA ligase activity
M8X21_RS13610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8X21_RS13615	COG1388	LysM domain
M8X21_RS13625	COG0113	porphobilinogen synthase activity
M8X21_RS13630	COG1587	Uroporphyrinogen-III synthase
M8X21_RS13640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8X21_RS13660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M8X21_RS13665	COG1067	ATP-dependent peptidase activity
M8X21_RS13665	COG0470	DNA polymerase III
M8X21_RS13680	COG0457	Tetratricopeptide repeat
M8X21_RS13680	COG1477	protein flavinylation
M8X21_RS13695	COG0473	3-isopropylmalate dehydrogenase activity
M8X21_RS13710	COG0440	acetolactate synthase activity
M8X21_RS13715	COG0028	Belongs to the TPP enzyme family
M8X21_RS13740	COG0622	Phosphoesterase
M8X21_RS13745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M8X21_RS13755	COG5401	PFAM Sporulation and spore germination
M8X21_RS13765	COG1846	Transcriptional regulator
M8X21_RS13775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M8X21_RS13780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M8X21_RS13805	COG0457	Tetratricopeptide repeat
M8X21_RS13810	COG5444	nuclease activity
M8X21_RS13900	COG5280	Phage tail tape measure protein TP901
M8X21_RS13900	COG3953	SLT domain
M8X21_RS13970	COG5484	DNA packaging
M8X21_RS13980	COG3677	Transposase
M8X21_RS14080	COG1484	DNA-dependent DNA replication
M8X21_RS14090	COG3723	Recombinational DNA repair protein, rece pathway
M8X21_RS14095	COG5377	YqaJ viral recombinase family
M8X21_RS14125	COG3617	BRO family, N-terminal domain
M8X21_RS14140	COG3620	sequence-specific DNA binding
M8X21_RS14150	COG2856	Zn peptidase
M8X21_RS14155	COG2197	response regulator
M8X21_RS14160	COG0824	Thioesterase
M8X21_RS14165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M8X21_RS14170	COG1053	succinate dehydrogenase
M8X21_RS14175	COG2009	succinate dehydrogenase
M8X21_RS14180	COG1719	4-vinyl reductase, 4VR
M8X21_RS14185	COG0527	aspartate kinase activity
M8X21_RS14195	COG3118	belongs to the thioredoxin family
M8X21_RS14200	COG3534	alpha-L-arabinofuranosidase
M8X21_RS14205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M8X21_RS14210	COG2086	electron transfer activity
M8X21_RS14215	COG1024	Enoyl-CoA hydratase
M8X21_RS14220	COG1309	transcriptional regulator
M8X21_RS14225	COG0318	PFAM AMP-dependent synthetase and ligase
M8X21_RS14235	COG3766	membrane
M8X21_RS14245	COG1796	DNA polymerase
M8X21_RS14245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8X21_RS14250	COG1286	toxin biosynthetic process
M8X21_RS14265	COG0072	phenylalanine-tRNA ligase activity
M8X21_RS14265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8X21_RS14270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M8X21_RS14275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8X21_RS14285	COG3835	regulator
M8X21_RS14290	COG0277	FAD linked oxidase domain protein
M8X21_RS14295	COG0247	lactate metabolic process
M8X21_RS14300	COG1966	Carbon starvation protein
M8X21_RS14305	COG3534	alpha-L-arabinofuranosidase
M8X21_RS14310	COG0395	ABC-type sugar transport system, permease component
M8X21_RS14315	COG1175	transmembrane transport
M8X21_RS14320	COG1653	transport
M8X21_RS14330	COG0647	UMP catabolic process
M8X21_RS14335	COG0235	Class ii aldolase
M8X21_RS14340	COG1069	ribulokinase activity
M8X21_RS14345	COG2160	L-arabinose isomerase activity
M8X21_RS14350	COG3507	Belongs to the glycosyl hydrolase 43 family
M8X21_RS14355	COG1363	Peptidase, m42
M8X21_RS14365	COG3326	Membrane
M8X21_RS14380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M8X21_RS14385	COG1346	cytolysis
M8X21_RS14390	COG1380	Effector of murein hydrolase LrgA
M8X21_RS14395	COG3279	Response regulator of the LytR AlgR family
M8X21_RS14400	COG3275	phosphorelay sensor kinase activity
M8X21_RS14405	COG1011	Hydrolase
M8X21_RS14420	COG0398	Pfam SNARE associated Golgi protein
M8X21_RS14425	COG1484	DNA-dependent DNA replication
M8X21_RS14430	COG3611	Membrane attachment protein
M8X21_RS14445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8X21_RS14450	COG1733	regulation of RNA biosynthetic process
M8X21_RS14455	COG2814	Major facilitator Superfamily
M8X21_RS14460	COG0656	L-ascorbic acid biosynthetic process
M8X21_RS14465	COG0237	dephospho-CoA kinase activity
M8X21_RS14470	COG1971	Probably functions as a manganese efflux pump
M8X21_RS14475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M8X21_RS14480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS14480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS14485	COG5002	protein histidine kinase activity
M8X21_RS14490	COG0745	RESPONSE REGULATOR receiver
M8X21_RS14500	COG0538	isocitrate dehydrogenase activity
M8X21_RS14505	COG0372	Belongs to the citrate synthase family
M8X21_RS14515	COG0457	Tetratricopeptide repeat
M8X21_RS14540	COG0628	permease
M8X21_RS14545	COG3030	protein affecting phage T7 exclusion by the F plasmid
M8X21_RS14550	COG0469	pyruvate kinase activity
M8X21_RS14570	COG0281	malic enzyme
M8X21_RS14575	COG0587	DNA-directed DNA polymerase activity
M8X21_RS14595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M8X21_RS14605	COG4109	DRTGG domain
M8X21_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS14630	COG0521	Mo-molybdopterin cofactor biosynthetic process
M8X21_RS14640	COG0827	DNA restriction-modification system
M8X21_RS14645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M8X21_RS14650	COG3874	Sporulation protein YtfJ
M8X21_RS14660	COG1714	RDD family
M8X21_RS14665	COG0616	signal peptide processing
M8X21_RS14670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8X21_RS14675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M8X21_RS14680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8X21_RS14695	COG1104	cysteine desulfurase activity
M8X21_RS14700	COG1114	Component of the transport system for branched-chain amino acids
M8X21_RS14710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8X21_RS14715	COG1309	transcriptional regulator
M8X21_RS14720	COG1956	GAF domain-containing protein
M8X21_RS14725	COG2199	diguanylate cyclase activity
M8X21_RS14725	COG2203	Gaf domain
M8X21_RS14735	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS14770	COG1017	nitric oxide dioxygenase activity
M8X21_RS14770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8X21_RS14780	COG0693	protein deglycase activity
M8X21_RS14795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8X21_RS14800	COG1378	Sugar-specific transcriptional regulator TrmB
M8X21_RS14820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8X21_RS14825	COG0454	-acetyltransferase
M8X21_RS14830	COG0517	IMP dehydrogenase activity
M8X21_RS14835	COG0123	including yeast histone deacetylase and acetoin utilization protein
M8X21_RS14840	COG1360	Flagellar Motor Protein
M8X21_RS14845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8X21_RS14850	COG1609	Transcriptional regulator
M8X21_RS14855	COG1605	Chorismate mutase
M8X21_RS14855	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M8X21_RS14860	COG3118	belongs to the thioredoxin family
M8X21_RS14865	COG4980	gas vesicle protein
M8X21_RS14870	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8X21_RS14880	COG1674	ftsk spoiiie
M8X21_RS14885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8X21_RS14895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS14905	COG1363	Peptidase, m42
M8X21_RS14910	COG5584	Small secreted protein
M8X21_RS14915	COG0281	malic enzyme
M8X21_RS14920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8X21_RS14935	COG0510	thiamine kinase activity
M8X21_RS14940	COG1597	lipid kinase activity
M8X21_RS14950	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M8X21_RS14955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8X21_RS14960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8X21_RS14965	COG2252	PERMEase
M8X21_RS14970	COG4473	ABC transporter
M8X21_RS14975	COG1131	(ABC) transporter
M8X21_RS14980	COG1349	DNA-binding transcription factor activity
M8X21_RS14985	COG1187	pseudouridine synthase activity
M8X21_RS14990	COG2244	polysaccharide biosynthetic process
M8X21_RS14995	COG2081	HI0933 family
M8X21_RS15000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M8X21_RS15015	COG1609	Transcriptional regulator
M8X21_RS15020	COG1653	transport
M8X21_RS15025	COG1175	transmembrane transport
M8X21_RS15030	COG0395	ABC-type sugar transport system, permease component
M8X21_RS15035	COG1486	melibiose metabolic process
M8X21_RS15045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8X21_RS15060	COG2202	Pas domain
M8X21_RS15060	COG1366	Belongs to the anti-sigma-factor antagonist family
M8X21_RS15065	COG2814	Major facilitator Superfamily
M8X21_RS15070	COG5522	Integral membrane protein (intg_mem_TP0381)
M8X21_RS15075	COG0577	efflux transmembrane transporter activity
M8X21_RS15080	COG1136	(ABC) transporter
M8X21_RS15085	COG2205	protein histidine kinase activity
M8X21_RS15090	COG0745	RESPONSE REGULATOR receiver
M8X21_RS15095	COG0577	efflux transmembrane transporter activity
M8X21_RS15100	COG1136	(ABC) transporter
M8X21_RS15120	COG1131	(ABC) transporter
M8X21_RS15125	COG1725	Transcriptional regulator
M8X21_RS15140	COG1242	4 iron, 4 sulfur cluster binding
M8X21_RS15145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M8X21_RS15155	COG0584	glycerophosphoryl diester phosphodiesterase
M8X21_RS15165	COG2267	carboxylic ester hydrolase activity
M8X21_RS15170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8X21_RS15175	COG1113	amino acid transport
M8X21_RS15180	COG0367	asparagine synthase
M8X21_RS15200	COG1506	peptidase
M8X21_RS15205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8X21_RS15210	COG1116	anion transmembrane transporter activity
M8X21_RS15215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8X21_RS15220	COG0494	nUDIX hydrolase
M8X21_RS15225	COG4824	toxin secretion phage lysis holin
M8X21_RS15230	COG0783	Belongs to the Dps family
M8X21_RS15255	COG0288	reversible hydration of carbon dioxide
M8X21_RS15265	COG1271	oxidase subunit
M8X21_RS15270	COG1294	oxidase, subunit
M8X21_RS15280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8X21_RS15285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8X21_RS15285	COG1321	iron dependent repressor
M8X21_RS15290	COG1121	(ABC) transporter
M8X21_RS15295	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8X21_RS15300	COG4948	Mandelate Racemase Muconate Lactonizing
M8X21_RS15310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M8X21_RS15315	COG0596	Alpha beta hydrolase
M8X21_RS15325	COG1169	isochorismate synthase
M8X21_RS15330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8X21_RS15335	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M8X21_RS15460	COG3859	Proton-coupled thiamine transporter YuaJ
M8X21_RS15465	COG2268	Band 7 protein
M8X21_RS15470	COG1585	Membrane protein implicated in regulation of membrane protease activity
M8X21_RS15475	COG2318	DinB family
M8X21_RS15485	COG1454	alcohol dehydrogenase
M8X21_RS15490	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS15495	COG1510	regulation of RNA biosynthetic process
M8X21_RS15505	COG0569	domain protein
M8X21_RS15510	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8X21_RS15515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8X21_RS15515	COG1017	nitric oxide dioxygenase activity
M8X21_RS15560	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS15560	COG1388	LysM domain
M8X21_RS15560	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS15585	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS15600	COG5280	Phage tail tape measure protein TP901
M8X21_RS15600	COG3953	SLT domain
M8X21_RS15645	COG0740	serine-type endopeptidase activity
M8X21_RS15715	COG1216	Glycosyl transferase, family 2
M8X21_RS15725	COG4195	phage-related replication protein
M8X21_RS15730	COG3420	alginic acid biosynthetic process
M8X21_RS15730	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS15755	COG1793	dna ligase
M8X21_RS15780	COG1595	DNA-templated transcription, initiation
M8X21_RS15815	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M8X21_RS15820	COG0756	dUTP diphosphatase activity
M8X21_RS15830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8X21_RS15850	COG1780	Probably involved in ribonucleotide reductase function
M8X21_RS15875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M8X21_RS15895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS15895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8X21_RS15985	COG1484	DNA-dependent DNA replication
M8X21_RS16045	COG4974	Belongs to the 'phage' integrase family
M8X21_RS16060	COG0628	permease
M8X21_RS16065	COG0673	inositol 2-dehydrogenase activity
M8X21_RS16070	COG0693	protein deglycase activity
M8X21_RS16075	COG0840	transmembrane signaling receptor activity
M8X21_RS16080	COG0840	transmembrane signaling receptor activity
M8X21_RS16085	COG0840	transmembrane signaling receptor activity
M8X21_RS16090	COG0840	transmembrane signaling receptor activity
M8X21_RS16105	COG2070	2-Nitropropane dioxygenase
M8X21_RS16110	COG0432	Pfam Uncharacterised protein family UPF0047
M8X21_RS16115	COG0366	Alpha amylase catalytic
M8X21_RS16120	COG1253	flavin adenine dinucleotide binding
M8X21_RS16125	COG2738	Putative neutral zinc metallopeptidase
M8X21_RS16140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M8X21_RS16165	COG1335	isochorismatase
M8X21_RS16170	COG1979	alcohol dehydrogenase
M8X21_RS16175	COG1979	alcohol dehydrogenase
M8X21_RS16180	COG2155	Conserved Protein
M8X21_RS16185	COG1098	S1 RNA binding domain
M8X21_RS16190	COG0436	Aminotransferase
M8X21_RS16195	COG1522	sequence-specific DNA binding
M8X21_RS16200	COG2267	carboxylic ester hydrolase activity
M8X21_RS16210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M8X21_RS16215	COG2205	protein histidine kinase activity
M8X21_RS16225	COG5018	Exonuclease
M8X21_RS16230	COG2814	Major facilitator Superfamily
M8X21_RS16235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8X21_RS16240	COG3011	Protein conserved in bacteria
M8X21_RS16250	COG3290	protein histidine kinase activity
M8X21_RS16255	COG4565	transcriptional regulatory protein
M8X21_RS16260	COG1744	ABC transporter substrate-binding protein PnrA-like
M8X21_RS16265	COG3845	ABC transporter
M8X21_RS16270	COG4603	Belongs to the binding-protein-dependent transport system permease family
M8X21_RS16275	COG1079	Belongs to the binding-protein-dependent transport system permease family
M8X21_RS16285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8X21_RS16285	COG2111	Na H antiporter
M8X21_RS16290	COG2111	Na H antiporter
M8X21_RS16295	COG1006	Multisubunit Na H antiporter MnhC subunit
M8X21_RS16300	COG0651	ATP synthesis coupled electron transport
M8X21_RS16305	COG1863	multisubunit Na H antiporter MnhE subunit
M8X21_RS16310	COG2212	antiporter activity
M8X21_RS16315	COG1320	monovalent cation:proton antiporter activity
M8X21_RS16320	COG2050	protein possibly involved in aromatic compounds catabolism
M8X21_RS16325	COG2197	response regulator
M8X21_RS16340	COG0142	geranyltranstransferase activity
M8X21_RS16355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M8X21_RS16360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M8X21_RS16365	COG1335	isochorismatase
M8X21_RS16370	COG5506	Protein of unknown function (DUF1694)
M8X21_RS16385	COG0628	permease
M8X21_RS16395	COG1418	mRNA catabolic process
M8X21_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS16410	COG1511	domain protein
M8X21_RS16415	COG0433	COG0433 Predicted ATPase
M8X21_RS16415	COG1674	ftsk spoiiie
M8X21_RS16420	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8X21_RS16425	COG5417	Belongs to the EsaB family
M8X21_RS16430	COG4842	Belongs to the WXG100 family
M8X21_RS16435	COG2508	Transcriptional regulator
M8X21_RS16435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M8X21_RS16440	COG0686	Belongs to the AlaDH PNT family
M8X21_RS16445	COG5634	Uncharacterized conserved protein (DUF2278)
M8X21_RS16450	COG3251	PFAM MbtH domain protein
M8X21_RS16455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS16460	COG3433	isochorismatase activity
M8X21_RS16460	COG1535	isochorismatase
M8X21_RS16465	COG1021	2,3-dihydroxybenzoate-AMP ligase
M8X21_RS16470	COG1169	isochorismate synthase
M8X21_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS16480	COG2819	hydrolase of the alpha beta superfamily
M8X21_RS16485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8X21_RS16490	COG1268	BioY protein
M8X21_RS16495	COG2056	Na+-H+ antiporter family
M8X21_RS16505	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M8X21_RS16510	COG3584	3D domain protein
M8X21_RS16525	COG1252	NADH dehydrogenase
M8X21_RS16555	COG1131	(ABC) transporter
M8X21_RS16575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8X21_RS16580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M8X21_RS16585	COG0316	Belongs to the HesB IscA family
M8X21_RS16595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8X21_RS16605	COG1252	NADH dehydrogenase
M8X21_RS16610	COG4837	Protein of unknown function (DUF1462)
M8X21_RS16615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M8X21_RS16620	COG0823	Involved in the tonB-independent uptake of proteins
M8X21_RS16620	COG1506	peptidase
M8X21_RS16620	COG4946	Tricorn protease homolog
M8X21_RS16630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M8X21_RS16635	COG0460	homoserine dehydrogenase
M8X21_RS16640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8X21_RS16645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M8X21_RS16650	COG0647	UMP catabolic process
M8X21_RS16655	COG2445	Protein of unknown function DUF86
M8X21_RS16660	COG4470	Protein conserved in bacteria
M8X21_RS16670	COG0739	heme binding
M8X21_RS16680	COG0737	Belongs to the 5'-nucleotidase family
M8X21_RS16685	COG0730	response to heat
M8X21_RS16690	COG1801	Protein of unknown function DUF72
M8X21_RS16705	COG2508	Transcriptional regulator
M8X21_RS16710	COG0457	Tetratricopeptide repeat
M8X21_RS16725	COG2814	Major facilitator Superfamily
M8X21_RS16730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M8X21_RS16735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8X21_RS16740	COG2356	endonuclease I
M8X21_RS16745	COG3842	ATPase activity
M8X21_RS16750	COG2188	Transcriptional regulator
M8X21_RS16755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8X21_RS16760	COG0395	ABC-type sugar transport system, permease component
M8X21_RS16765	COG1175	transmembrane transport
M8X21_RS16770	COG1653	transport
M8X21_RS16775	COG2222	sugar isomerase
M8X21_RS16780	COG0789	Transcriptional regulator
M8X21_RS16805	COG0322	excinuclease ABC activity
M8X21_RS16810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8X21_RS16830	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS16835	COG0719	Fe-S assembly protein
M8X21_RS16840	COG0822	iron-sulfur transferase activity
M8X21_RS16845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8X21_RS16850	COG0719	Fe-S assembly protein
M8X21_RS16855	COG0396	ATPase activity
M8X21_RS16865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8X21_RS16870	COG1464	Belongs to the NlpA lipoprotein family
M8X21_RS16875	COG2011	ABC-type metal ion transport system permease component
M8X21_RS16880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8X21_RS16890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS16895	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8X21_RS16910	COG1393	Belongs to the ArsC family
M8X21_RS16915	COG1960	acyl-CoA dehydrogenase activity
M8X21_RS16920	COG0183	Belongs to the thiolase family
M8X21_RS16925	COG1024	Enoyl-CoA hydratase
M8X21_RS16925	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8X21_RS16945	COG5577	PFAM Coat F domain
M8X21_RS16950	COG1846	Transcriptional regulator
M8X21_RS16955	COG0477	Major facilitator Superfamily
M8X21_RS16960	COG0583	DNA-binding transcription factor activity
M8X21_RS16980	COG1120	ATPase activity
M8X21_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS17000	COG0783	Belongs to the Dps family
M8X21_RS17005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8X21_RS17010	COG0745	RESPONSE REGULATOR receiver
M8X21_RS17015	COG2770	Histidine kinase
M8X21_RS17015	COG2205	protein histidine kinase activity
M8X21_RS17025	COG1309	transcriptional regulator
M8X21_RS17030	COG0114	fumarate hydratase activity
M8X21_RS17040	COG0697	spore germination
M8X21_RS17045	COG0814	amino acid
M8X21_RS17055	COG2197	response regulator
M8X21_RS17060	COG4585	Histidine kinase
M8X21_RS17065	COG4758	membrane
M8X21_RS17070	COG3595	metallopeptidase activity
M8X21_RS17075	COG1842	Phage shock protein A
M8X21_RS17080	COG4758	membrane
M8X21_RS17085	COG2814	Major facilitator Superfamily
M8X21_RS17090	COG2096	Adenosyltransferase
M8X21_RS17095	COG1120	ATPase activity
M8X21_RS17100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS17105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8X21_RS17110	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS17115	COG3386	PFAM SMP-30 Gluconolaconase
M8X21_RS17120	COG2205	protein histidine kinase activity
M8X21_RS17125	COG0745	RESPONSE REGULATOR receiver
M8X21_RS17135	COG1191	sigma factor activity
M8X21_RS17145	COG2140	Oxalate decarboxylase
M8X21_RS17155	COG1120	ATPase activity
M8X21_RS17160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS17165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS17170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8X21_RS17175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M8X21_RS17180	COG0531	amino acid
M8X21_RS17190	COG1988	membrane-bound metal-dependent
M8X21_RS17195	COG1368	sulfuric ester hydrolase activity
M8X21_RS17200	COG1910	domain protein
M8X21_RS17205	COG0725	ABC transporter, periplasmic molybdate-binding protein
M8X21_RS17210	COG4149	molybdate abc transporter
M8X21_RS17215	COG2197	response regulator
M8X21_RS17220	COG3850	Histidine kinase
M8X21_RS17225	COG1131	(ABC) transporter
M8X21_RS17235	COG0842	Transport permease protein
M8X21_RS17240	COG0656	L-ascorbic acid biosynthetic process
M8X21_RS17260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8X21_RS17265	COG3973	AAA domain
M8X21_RS17270	COG2860	membrane
M8X21_RS17280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M8X21_RS17285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M8X21_RS17290	COG2217	Heavy metal translocating P-type atpase
M8X21_RS17300	COG2608	mercury ion transmembrane transporter activity
M8X21_RS17305	COG1937	Protein conserved in bacteria
M8X21_RS17310	COG0673	inositol 2-dehydrogenase activity
M8X21_RS17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS17325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M8X21_RS17330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS17335	COG1126	abc transporter atp-binding protein
M8X21_RS17340	COG0765	amino acid transport
M8X21_RS17345	COG0765	amino acid transport
M8X21_RS17350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS17355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8X21_RS17360	COG0454	-acetyltransferase
M8X21_RS17365	COG0583	DNA-binding transcription factor activity
M8X21_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS17375	COG2732	(Barnase) inhibitor
M8X21_RS17380	COG2732	(Barnase) inhibitor
M8X21_RS17395	COG0557	exoribonuclease II activity
M8X21_RS17400	COG1647	Serine aminopeptidase, S33
M8X21_RS17405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8X21_RS17410	COG1476	TRANSCRIPTIONal
M8X21_RS17415	COG1396	sequence-specific DNA binding
M8X21_RS17420	COG1396	sequence-specific DNA binding
M8X21_RS17425	COG1733	regulation of RNA biosynthetic process
M8X21_RS17450	COG1131	(ABC) transporter
M8X21_RS17455	COG1174	glycine betaine transport
M8X21_RS17460	COG1732	Glycine betaine
M8X21_RS17465	COG1174	glycine betaine transport
M8X21_RS17470	COG1125	glycine betaine transport
M8X21_RS17470	COG0517	IMP dehydrogenase activity
M8X21_RS17475	COG1510	regulation of RNA biosynthetic process
M8X21_RS17480	COG1174	glycine betaine transport
M8X21_RS17485	COG1732	Glycine betaine
M8X21_RS17490	COG1174	glycine betaine transport
M8X21_RS17495	COG0517	IMP dehydrogenase activity
M8X21_RS17495	COG1125	glycine betaine transport
M8X21_RS17500	COG1510	regulation of RNA biosynthetic process
M8X21_RS17505	COG2095	MarC family integral membrane protein
M8X21_RS17510	COG3064	Membrane
M8X21_RS17515	COG4640	response to antibiotic
M8X21_RS17520	COG0456	acetyltransferase
M8X21_RS17540	COG0126	phosphoglycerate kinase activity
M8X21_RS17545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8X21_RS17550	COG2390	Transcriptional regulator
M8X21_RS17555	COG2814	Major facilitator Superfamily
M8X21_RS17560	COG1609	Transcriptional regulator
M8X21_RS17565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS17570	COG0583	DNA-binding transcription factor activity
M8X21_RS17575	COG0697	spore germination
M8X21_RS17580	COG1113	amino acid transport
M8X21_RS17590	COG1737	Transcriptional regulator
M8X21_RS17595	COG1070	Carbohydrate kinase
M8X21_RS17625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS17630	COG2186	Transcriptional regulator
M8X21_RS17635	COG1620	l-lactate permease
M8X21_RS17640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M8X21_RS17650	COG5039	Polysaccharide pyruvyl transferase
M8X21_RS17655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8X21_RS17660	COG0110	maltose O-acetyltransferase activity
M8X21_RS17665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M8X21_RS17670	COG2244	polysaccharide biosynthetic process
M8X21_RS17675	COG1216	Glycosyl transferase, family 2
M8X21_RS17680	COG5039	Polysaccharide pyruvyl transferase
M8X21_RS17685	COG1216	Glycosyl transferase, family 2
M8X21_RS17695	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS17700	COG1215	transferase activity, transferring glycosyl groups
M8X21_RS17705	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS17710	COG1086	Polysaccharide biosynthesis protein
M8X21_RS17715	COG0489	protein tyrosine kinase activity
M8X21_RS17720	COG3944	biosynthesis protein
M8X21_RS17725	COG1396	sequence-specific DNA binding
M8X21_RS17730	COG2272	Belongs to the type-B carboxylesterase lipase family
M8X21_RS17740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8X21_RS17745	COG2364	Membrane
M8X21_RS17750	COG0456	acetyltransferase
M8X21_RS17755	COG3479	Phenolic acid decarboxylase
M8X21_RS17815	COG2223	nitrite transmembrane transporter activity
M8X21_RS17820	COG1609	Transcriptional regulator
M8X21_RS17830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8X21_RS17835	COG0366	Alpha amylase catalytic
M8X21_RS17840	COG1554	hydrolase, family 65, central catalytic
M8X21_RS17845	COG5521	maltodextrose utilization protein MalA
M8X21_RS17850	COG3833	ABC-type maltose transport systems, permease component
M8X21_RS17855	COG1175	transmembrane transport
M8X21_RS17860	COG2182	Extracellular solute-binding protein
M8X21_RS17865	COG0366	Alpha amylase catalytic
M8X21_RS17870	COG1609	Transcriptional regulator
M8X21_RS17875	COG1611	Belongs to the LOG family
M8X21_RS17880	COG1694	Mazg nucleotide pyrophosphohydrolase
M8X21_RS17885	COG0659	secondary active sulfate transmembrane transporter activity
M8X21_RS17890	COG0288	reversible hydration of carbon dioxide
M8X21_RS17895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8X21_RS17900	COG4290	ribonuclease
M8X21_RS17905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M8X21_RS17910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS17920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M8X21_RS17930	COG1051	belongs to the nudix hydrolase family
M8X21_RS17935	COG0492	ferredoxin-NADP+ reductase activity
M8X21_RS17940	COG3883	PFAM NLP P60 protein
M8X21_RS17940	COG0791	NLP P60 protein
M8X21_RS17945	COG0457	Tetratricopeptide repeat
M8X21_RS17950	COG5002	protein histidine kinase activity
M8X21_RS17955	COG0745	RESPONSE REGULATOR receiver
M8X21_RS17965	COG1132	(ABC) transporter
M8X21_RS17970	COG0140	phosphoribosyl-ATP diphosphatase activity
M8X21_RS17970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M8X21_RS17995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M8X21_RS18010	COG4990	cell redox homeostasis
M8X21_RS18015	COG0110	maltose O-acetyltransferase activity
M8X21_RS18035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M8X21_RS18045	COG2188	Transcriptional regulator
M8X21_RS18050	COG1309	transcriptional regulator
M8X21_RS18055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M8X21_RS18060	COG1950	PFAM Membrane protein of
M8X21_RS18065	COG1983	PspC domain protein
M8X21_RS18070	COG3595	metallopeptidase activity
M8X21_RS18085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M8X21_RS18095	COG4897	Protein conserved in bacteria
M8X21_RS18100	COG3848	Pyruvate phosphate dikinase
M8X21_RS18100	COG0574	Belongs to the PEP-utilizing enzyme family
M8X21_RS18105	COG1309	transcriptional regulator
M8X21_RS18110	COG2814	Major facilitator Superfamily
M8X21_RS18135	COG1132	(ABC) transporter
M8X21_RS18140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8X21_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS18160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8X21_RS18170	COG3409	Peptidoglycan-binding domain 1 protein
M8X21_RS18170	COG0793	Belongs to the peptidase S41A family
M8X21_RS18175	COG3420	alginic acid biosynthetic process
M8X21_RS18180	COG2177	Part of the ABC transporter FtsEX involved in
M8X21_RS18185	COG2884	Cell division ATP-binding protein ftsE
M8X21_RS18190	COG2010	Cytochrome c
M8X21_RS18195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS18210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M8X21_RS18225	COG1516	flagellar protein fliS
M8X21_RS18230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M8X21_RS18235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8X21_RS18255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8X21_RS18260	COG1256	bacterial-type flagellum assembly
M8X21_RS18260	COG4786	Flagellar basal body rod
M8X21_RS18265	COG3418	PFAM FlgN family protein
M8X21_RS18270	COG2747	anti-sigma28 factor FlgM
M8X21_RS18280	COG1040	competence protein
M8X21_RS18290	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M8X21_RS18295	COG1307	EDD domain protein, DegV family
M8X21_RS18300	COG2197	response regulator
M8X21_RS18305	COG4585	Histidine kinase
M8X21_RS18310	COG1739	Uncharacterized protein family UPF0029
M8X21_RS18315	COG1316	TRANSCRIPTIONal
M8X21_RS18320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8X21_RS18325	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS18330	COG1215	transferase activity, transferring glycosyl groups
M8X21_RS18335	COG3206	protein involved in exopolysaccharide biosynthesis
M8X21_RS18340	COG3307	-O-antigen
M8X21_RS18345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8X21_RS18350	COG0297	glycogen (starch) synthase activity
M8X21_RS18350	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS18355	COG2244	polysaccharide biosynthetic process
M8X21_RS18365	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8X21_RS18365	COG2247	cell wall binding repeat
M8X21_RS18370	COG2247	cell wall binding repeat
M8X21_RS18370	COG2385	sporulation resulting in formation of a cellular spore
M8X21_RS18380	COG1316	TRANSCRIPTIONal
M8X21_RS18385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M8X21_RS18390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8X21_RS18395	COG1134	teichoic acid transport
M8X21_RS18400	COG1682	transport, permease protein
M8X21_RS18405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8X21_RS18410	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS18415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M8X21_RS18420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M8X21_RS18425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8X21_RS18430	COG4193	domain, Protein
M8X21_RS18435	COG1482	cell wall glycoprotein biosynthetic process
M8X21_RS18440	COG0697	spore germination
M8X21_RS18445	COG0814	amino acid
M8X21_RS18455	COG1215	transferase activity, transferring glycosyl groups
M8X21_RS18460	COG2814	Major facilitator Superfamily
M8X21_RS18465	COG1316	TRANSCRIPTIONal
M8X21_RS18470	COG0561	phosphatase activity
M8X21_RS18475	COG2433	Pfam Transposase IS66
M8X21_RS18480	COG0791	NLP P60 protein
M8X21_RS18490	COG2843	Capsule synthesis protein
M8X21_RS18500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8X21_RS18505	COG0697	spore germination
M8X21_RS18510	COG0814	amino acid
M8X21_RS18520	COG1609	Transcriptional regulator
M8X21_RS18525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8X21_RS18535	COG1129	ABC transporter
M8X21_RS18540	COG1172	Belongs to the binding-protein-dependent transport system permease family
M8X21_RS18545	COG1879	ABC-type sugar transport system periplasmic component
M8X21_RS18550	COG3103	Sh3 type 3 domain protein
M8X21_RS18555	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8X21_RS18560	COG3527	Alpha-acetolactate decarboxylase
M8X21_RS18565	COG0028	Belongs to the TPP enzyme family
M8X21_RS18570	COG0583	DNA-binding transcription factor activity
M8X21_RS18575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8X21_RS18590	COG5337	Spore coat protein CotH
M8X21_RS18600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8X21_RS18610	COG0405	Gamma-glutamyltransferase
M8X21_RS18615	COG1522	sequence-specific DNA binding
M8X21_RS18620	COG2059	Chromate
M8X21_RS18625	COG2059	Chromate
M8X21_RS18635	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8X21_RS18640	COG0583	DNA-binding transcription factor activity
M8X21_RS18655	COG5444	nuclease activity
M8X21_RS18670	COG3878	Protein conserved in bacteria
M8X21_RS18675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8X21_RS18680	COG4464	protein tyrosine phosphatase activity
M8X21_RS18685	COG0489	protein tyrosine kinase activity
M8X21_RS18690	COG3944	biosynthesis protein
M8X21_RS18700	COG4715	Zinc finger, swim domain protein
M8X21_RS18705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8X21_RS18710	COG0561	phosphatase activity
M8X21_RS18715	COG1349	DNA-binding transcription factor activity
M8X21_RS18720	COG0629	single-stranded DNA binding
M8X21_RS18745	COG0457	Tetratricopeptide repeat
M8X21_RS18750	COG4786	Flagellar basal body rod
M8X21_RS18755	COG4786	Flagellar basal body rod
M8X21_RS18760	COG1077	Cell shape determining protein MreB Mrl
M8X21_RS18765	COG1609	Transcriptional regulator
M8X21_RS18770	COG1846	Transcriptional regulator
M8X21_RS18775	COG2814	Major facilitator Superfamily
M8X21_RS18780	COG1953	Uracil, thiamine, allantoin
M8X21_RS18785	COG0477	Major facilitator Superfamily
M8X21_RS18790	COG1335	isochorismatase
M8X21_RS18795	COG0004	ammonium transporteR
M8X21_RS18800	COG0347	Belongs to the P(II) protein family
M8X21_RS18805	COG0772	Belongs to the SEDS family
M8X21_RS18810	COG0671	phosphoesterase, PA-phosphatase related
M8X21_RS18820	COG0739	heme binding
M8X21_RS18825	COG1247	-acetyltransferase
M8X21_RS18840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8X21_RS18850	COG0726	polysaccharide deacetylase
M8X21_RS18855	COG1959	2 iron, 2 sulfur cluster binding
M8X21_RS18870	COG0831	urea catabolic process
M8X21_RS18880	COG1994	Peptidase M50
M8X21_RS18885	COG0457	Tetratricopeptide repeat
M8X21_RS18895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M8X21_RS18905	COG2304	oxidoreductase activity
M8X21_RS18910	COG2304	oxidoreductase activity
M8X21_RS18915	COG2385	sporulation resulting in formation of a cellular spore
M8X21_RS18920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8X21_RS18930	COG4836	Membrane
M8X21_RS19000	COG0698	ribose 5-phosphate isomerase
M8X21_RS19005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8X21_RS19015	COG0009	L-threonylcarbamoyladenylate synthase
M8X21_RS19020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M8X21_RS19040	COG2890	protein-(glutamine-N5) methyltransferase activity
M8X21_RS19045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M8X21_RS19050	COG0346	lactoylglutathione lyase activity
M8X21_RS19055	COG0789	Transcriptional regulator
M8X21_RS19060	COG0679	Auxin Efflux Carrier
M8X21_RS19065	COG0281	malic enzyme
M8X21_RS19080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M8X21_RS19090	COG1494	fructose-1,6-bisphosphatase
M8X21_RS19095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8X21_RS19105	COG0191	fructose-bisphosphate aldolase activity
M8X21_RS19110	COG2204	response regulator
M8X21_RS19115	COG4821	SIS domain
M8X21_RS19130	COG0247	lactate metabolic process
M8X21_RS19130	COG2181	nitrate reductase activity
M8X21_RS19135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8X21_RS19150	COG1132	(ABC) transporter
M8X21_RS19155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8X21_RS19165	COG2181	nitrate reductase activity
M8X21_RS19170	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M8X21_RS19175	COG1140	nitrate reductase beta subunit
M8X21_RS19180	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M8X21_RS19185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8X21_RS19195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8X21_RS19200	COG2223	nitrite transmembrane transporter activity
M8X21_RS19210	COG4506	Protein conserved in bacteria
M8X21_RS19215	COG0457	Tetratricopeptide repeat
M8X21_RS19255	COG0010	Belongs to the arginase family
M8X21_RS19260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M8X21_RS19265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8X21_RS19280	COG1994	Peptidase M50
M8X21_RS19285	COG1942	4-Oxalocrotonate Tautomerase
M8X21_RS19290	COG1846	Transcriptional regulator
M8X21_RS19295	COG0531	amino acid
M8X21_RS19300	COG3465	dGTPase activity
M8X21_RS19305	COG1078	dGTPase activity
M8X21_RS19320	COG1695	Transcriptional regulator
M8X21_RS19330	COG1131	(ABC) transporter
M8X21_RS19335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8X21_RS19365	COG0583	DNA-binding transcription factor activity
M8X21_RS19370	COG2855	membrane
M8X21_RS19375	COG0280	phosphate acetyltransferase
M8X21_RS19385	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS19390	COG0436	Aminotransferase
M8X21_RS19420	COG2814	Major facilitator Superfamily
M8X21_RS19425	COG2814	Major facilitator Superfamily
M8X21_RS19430	COG0833	amino acid
M8X21_RS19435	COG4187	Peptidase family M20/M25/M40
M8X21_RS19440	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS19445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8X21_RS19450	COG2205	protein histidine kinase activity
M8X21_RS19455	COG0745	RESPONSE REGULATOR receiver
M8X21_RS19470	COG1131	(ABC) transporter
M8X21_RS19475	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M8X21_RS19480	COG1091	dTDP-4-dehydrorhamnose reductase activity
M8X21_RS19485	COG1088	dTDP-glucose 4,6-dehydratase activity
M8X21_RS19490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M8X21_RS19495	COG3980	spore coat polysaccharide biosynthesis protein
M8X21_RS19500	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M8X21_RS19505	COG2089	acid synthase
M8X21_RS19510	COG0456	acetyltransferase
M8X21_RS19515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8X21_RS19520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8X21_RS19525	COG0463	Glycosyl transferase, family 2
M8X21_RS19535	COG2363	Small membrane protein
M8X21_RS19540	COG2233	PERMEase
M8X21_RS19555	COG1216	Glycosyl transferase, family 2
M8X21_RS19570	COG1695	Transcriptional regulator
M8X21_RS19575	COG0351	phosphomethylpyrimidine kinase
M8X21_RS19585	COG1621	beta-fructofuranosidase activity
M8X21_RS19590	COG1263	PTS System
M8X21_RS19590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8X21_RS19595	COG3711	transcriptional antiterminator
M8X21_RS19605	COG1404	Belongs to the peptidase S8 family
M8X21_RS19610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8X21_RS19615	COG0778	Nitroreductase
M8X21_RS19620	COG0772	Belongs to the SEDS family
M8X21_RS19625	COG0454	-acetyltransferase
M8X21_RS19645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8X21_RS19650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8X21_RS19655	COG2261	transglycosylase associated protein
M8X21_RS19660	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8X21_RS19670	COG2246	polysaccharide biosynthetic process
M8X21_RS19675	COG1309	transcriptional regulator
M8X21_RS19695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8X21_RS19700	COG2837	iron assimilation
M8X21_RS19720	COG0583	DNA-binding transcription factor activity
M8X21_RS19730	COG1346	cytolysis
M8X21_RS19735	COG4895	conserved protein (DUF2196)
M8X21_RS19740	COG0789	Transcriptional regulator
M8X21_RS19745	COG5504	Zn-dependent protease
M8X21_RS19750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M8X21_RS19755	COG0346	lactoylglutathione lyase activity
M8X21_RS19760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS19765	COG1404	Belongs to the peptidase S8 family
M8X21_RS19770	COG1442	glycosyl transferase family 8
M8X21_RS19775	COG1846	Transcriptional regulator
M8X21_RS19780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M8X21_RS19785	COG2357	RelA SpoT domain protein
M8X21_RS19790	COG1575	Belongs to the MenA family. Type 1 subfamily
M8X21_RS19805	COG1696	Membrane protein involved in D-alanine export
M8X21_RS19815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M8X21_RS19820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8X21_RS19825	COG1486	melibiose metabolic process
M8X21_RS19830	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8X21_RS19835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS19840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS19845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8X21_RS19845	COG3711	transcriptional antiterminator
M8X21_RS19860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS19865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8X21_RS19875	COG0640	Transcriptional regulator
M8X21_RS19880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8X21_RS19885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS19890	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8X21_RS19895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8X21_RS19900	COG2723	6-phospho-beta-galactosidase activity
M8X21_RS19905	COG1940	carbohydrate kinase activity
M8X21_RS19910	COG1482	cell wall glycoprotein biosynthetic process
M8X21_RS19920	COG0753	catalase activity
M8X21_RS19925	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M8X21_RS19930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8X21_RS19935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M8X21_RS19940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M8X21_RS19945	COG4988	ABC transporter
M8X21_RS19950	COG1294	oxidase, subunit
M8X21_RS19955	COG1271	oxidase subunit
M8X21_RS19960	COG3493	citrate carrier protein
M8X21_RS19965	COG0726	polysaccharide deacetylase
M8X21_RS19970	COG3842	ATPase activity
M8X21_RS19975	COG2508	Transcriptional regulator
M8X21_RS19980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS19990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8X21_RS20005	COG4894	glucomannan catabolic process
M8X21_RS20010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M8X21_RS20015	COG0500	methyltransferase
M8X21_RS20020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8X21_RS20040	COG0753	catalase activity
M8X21_RS20040	COG0693	protein deglycase activity
M8X21_RS20045	COG2851	Citrate transporter
M8X21_RS20050	COG2273	Hydrolase Family 16
M8X21_RS20055	COG3711	transcriptional antiterminator
M8X21_RS20060	COG2270	Major facilitator Superfamily
M8X21_RS20065	COG0513	Belongs to the DEAD box helicase family
M8X21_RS20165	COG3209	COG3209 Rhs family protein
M8X21_RS20175	COG0697	spore germination
M8X21_RS20180	COG0589	response to stress
M8X21_RS20190	COG0494	nUDIX hydrolase
M8X21_RS20195	COG3507	Belongs to the glycosyl hydrolase 43 family
M8X21_RS20220	COG0010	Belongs to the arginase family
M8X21_RS20225	COG0833	amino acid
M8X21_RS20230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M8X21_RS20235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8X21_RS20245	COG2390	Transcriptional regulator
M8X21_RS20250	COG0561	phosphatase activity
M8X21_RS20280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8X21_RS20285	COG5294	Protein conserved in bacteria
M8X21_RS20290	COG0577	efflux transmembrane transporter activity
M8X21_RS20295	COG1136	(ABC) transporter
M8X21_RS20300	COG2205	protein histidine kinase activity
M8X21_RS20305	COG0745	RESPONSE REGULATOR receiver
M8X21_RS20310	COG2205	protein histidine kinase activity
M8X21_RS20315	COG0745	RESPONSE REGULATOR receiver
M8X21_RS20345	COG1082	Xylose isomerase domain protein TIM barrel
M8X21_RS20355	COG2814	Major facilitator Superfamily
M8X21_RS20385	COG1349	DNA-binding transcription factor activity
M8X21_RS20390	COG0667	Aldo Keto reductase
M8X21_RS20395	COG2814	Major facilitator Superfamily
M8X21_RS20410	COG1028	Short-chain dehydrogenase reductase Sdr
M8X21_RS20415	COG2197	response regulator
M8X21_RS20420	COG4585	Histidine kinase
M8X21_RS20425	COG3239	Fatty acid desaturase
M8X21_RS20430	COG1309	transcriptional regulator
M8X21_RS20435	COG1012	belongs to the aldehyde dehydrogenase family
M8X21_RS20440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M8X21_RS20450	COG0640	Transcriptional regulator
M8X21_RS20455	COG2814	Major facilitator Superfamily
M8X21_RS20460	COG1714	RDD family
M8X21_RS20470	COG0501	Belongs to the peptidase M48B family
M8X21_RS20475	COG1715	Restriction endonuclease
M8X21_RS20480	COG0450	alkyl hydroperoxide reductase
M8X21_RS20485	COG3634	alkyl hydroperoxide reductase activity
M8X21_RS20500	COG1113	amino acid transport
M8X21_RS20510	COG2080	2 iron, 2 sulfur cluster binding
M8X21_RS20525	COG2068	MobA-Related Protein
M8X21_RS20530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M8X21_RS20570	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8X21_RS20575	COG0667	Aldo Keto reductase
M8X21_RS20580	COG0456	acetyltransferase
M8X21_RS20585	COG0457	Tetratricopeptide repeat
M8X21_RS20590	COG0010	Belongs to the arginase family
M8X21_RS20595	COG0833	amino acid
M8X21_RS20600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8X21_RS20605	COG3829	transcription factor binding
M8X21_RS20615	COG0488	(ABC) transporter
M8X21_RS20630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8X21_RS20635	COG5002	protein histidine kinase activity
M8X21_RS20640	COG0745	RESPONSE REGULATOR receiver
M8X21_RS20650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8X21_RS20655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M8X21_RS20660	COG4853	Protein conserved in bacteria
M8X21_RS20665	COG4863	YycH protein
M8X21_RS20670	COG5002	protein histidine kinase activity
M8X21_RS20675	COG0745	RESPONSE REGULATOR receiver
M8X21_RS20705	COG0346	lactoylglutathione lyase activity
M8X21_RS20710	COG0305	Participates in initiation and elongation during chromosome replication
M8X21_RS20725	COG3093	addiction module antidote protein HigA
M8X21_RS20730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8X21_RS20745	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M8X21_RS20750	COG0438	transferase activity, transferring glycosyl groups
M8X21_RS20760	COG2112	serine threonine protein kinase
M8X21_RS20770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M8X21_RS20775	COG4241	membrane
M8X21_RS20785	COG5577	PFAM Coat F domain
M8X21_RS20790	COG1733	regulation of RNA biosynthetic process
M8X21_RS20800	COG0697	spore germination
M8X21_RS20805	COG1621	beta-fructofuranosidase activity
M8X21_RS20810	COG1621	beta-fructofuranosidase activity
M8X21_RS20815	COG1802	Transcriptional regulator
M8X21_RS20820	COG2318	DinB family
M8X21_RS20825	COG2211	Major facilitator Superfamily
M8X21_RS20835	COG0778	Nitroreductase
M8X21_RS20840	COG1846	Transcriptional regulator
M8X21_RS20845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8X21_RS20850	COG1846	Transcriptional regulator
M8X21_RS20855	COG2153	protein acetylation
M8X21_RS20865	COG0546	phosphoglycolate phosphatase activity
M8X21_RS20895	COG1404	Belongs to the peptidase S8 family
M8X21_RS20905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8X21_RS20910	COG0697	spore germination
M8X21_RS20915	COG1078	dGTPase activity
M8X21_RS20925	COG1331	Highly conserved protein containing a thioredoxin domain
M8X21_RS20930	COG1266	CAAX protease self-immunity
M8X21_RS20935	COG2814	Major facilitator Superfamily
M8X21_RS20935	COG0477	Major facilitator Superfamily
M8X21_RS20940	COG0346	lactoylglutathione lyase activity
M8X21_RS20945	COG1609	Transcriptional regulator
M8X21_RS20950	COG0708	Exodeoxyribonuclease III
M8X21_RS20955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8X21_RS20960	COG2169	Transcriptional regulator
M8X21_RS20970	COG0629	single-stranded DNA binding
M8X21_RS20980	COG0012	GTP binding
M8X21_RS20985	COG0243	molybdopterin cofactor binding
M8X21_RS20990	COG4481	Protein conserved in bacteria
M8X21_RS20995	COG3949	Membrane
M8X21_RS21010	COG1475	DNA binding
M8X21_RS21015	COG1192	Involved in chromosome partitioning
M8X21_RS21040	COG1847	R3H domain protein
M8X21_RS21045	COG0706	membrane insertase activity
M8X21_RS21165	COG3655	Transcriptional regulator
M8X21_RS21255	COG1793	dna ligase
M8X21_RS21260	COG2135	peptidase activity
M8X21_RS21275	COG4195	phage-related replication protein
M8X21_RS21280	COG3420	alginic acid biosynthetic process
M8X21_RS21280	COG5434	Belongs to the glycosyl hydrolase 28 family
M8X21_RS21305	COG2404	hydrolase activity, acting on ester bonds
M8X21_RS21345	COG3584	3D domain protein
M8X21_RS21360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M8X21_RS21460	COG1780	Probably involved in ribonucleotide reductase function
M8X21_RS21490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8X21_RS21495	COG0756	dUTP diphosphatase activity
M8X21_RS21525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M8X21_RS21530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8X21_RS21565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M8X21_RS21610	COG3331	DNA recombination
M8X21_RS21625	COG1525	nuclease
M8X21_RS21630	COG5444	nuclease activity
M8X21_RS21670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8X21_RS21705	COG4974	Belongs to the 'phage' integrase family
M8X21_RS21855	COG0776	regulation of translation
M8X21_RS21945	COG3655	Transcriptional regulator
M8X21_RS21950	COG3655	Transcriptional regulator