locus-tag	class	description
HCC49_RS00025	COG0516	GMP reductase activity
HCC49_RS00025	COG0517	IMP dehydrogenase activity
HCC49_RS00030	COG1686	Belongs to the peptidase S11 family
HCC49_RS00050	COG1929	Belongs to the glycerate kinase type-1 family
HCC49_RS00060	COG1428	Deoxynucleoside kinase
HCC49_RS00065	COG1428	Deoxynucleoside kinase
HCC49_RS00070	COG3858	chitin binding
HCC49_RS00070	COG1388	LysM domain
HCC49_RS00075	COG1335	isochorismatase
HCC49_RS00080	COG0590	tRNA wobble adenosine to inosine editing
HCC49_RS00090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCC49_RS00095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCC49_RS00125	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HCC49_RS00130	COG3853	Toxic anion resistance protein (TelA)
HCC49_RS00135	COG1982	Orn Lys Arg decarboxylase major
HCC49_RS00145	COG3870	Protein conserved in bacteria
HCC49_RS00150	COG1728	Protein conserved in bacteria
HCC49_RS00155	COG0470	DNA polymerase III
HCC49_RS00160	COG1774	PSP1 C-terminal conserved region
HCC49_RS00170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCC49_RS00180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCC49_RS00185	COG2002	toxin-antitoxin pair type II binding
HCC49_RS00190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCC49_RS00190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCC49_RS00195	COG0084	hydrolase, TatD family'
HCC49_RS00200	COG3584	3D domain protein
HCC49_RS00200	COG3583	domain protein
HCC49_RS00205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCC49_RS00210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCC49_RS00220	COG4466	Protein conserved in bacteria
HCC49_RS00235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCC49_RS00240	COG0251	oxidation-reduction process
HCC49_RS00255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCC49_RS00275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCC49_RS00280	COG2002	toxin-antitoxin pair type II binding
HCC49_RS00285	COG2244	polysaccharide biosynthetic process
HCC49_RS00290	COG3956	TIGRFAM MazG family protein
HCC49_RS00295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCC49_RS00310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HCC49_RS00315	COG1098	S1 RNA binding domain
HCC49_RS00330	COG2208	phosphoserine phosphatase activity
HCC49_RS00335	COG2304	oxidoreductase activity
HCC49_RS00340	COG0515	serine threonine protein kinase
HCC49_RS00345	COG0037	tRNA processing
HCC49_RS00355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCC49_RS00370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCC49_RS00375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCC49_RS00380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCC49_RS00385	COG0512	Glutamine amidotransferase of anthranilate synthase
HCC49_RS00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS00395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCC49_RS00400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCC49_RS00405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCC49_RS00410	COG1396	sequence-specific DNA binding
HCC49_RS00415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCC49_RS00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCC49_RS00480	COG4463	regulation of RNA biosynthetic process
HCC49_RS00485	COG3880	PFAM UvrB UvrC protein
HCC49_RS00495	COG0542	response to heat
HCC49_RS00500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCC49_RS00505	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HCC49_RS00510	COG4956	integral membrane protein (PIN domain superfamily)
HCC49_RS00530	COG1045	serine acetyltransferase
HCC49_RS00540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCC49_RS00545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCC49_RS00550	COG3688	RNA-binding protein containing a PIN domain
HCC49_RS00555	COG1595	DNA-templated transcription, initiation
HCC49_RS00565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCC49_RS00570	COG0250	Participates in transcription elongation, termination and antitermination
HCC49_RS00595	COG2813	Specifically methylates the guanine in position
HCC49_RS00610	COG1358	cellular component organization or biogenesis
HCC49_RS00635	COG0596	Alpha beta hydrolase
HCC49_RS00745	COG0201	protein transport
HCC49_RS00755	COG0024	Methionine aminopeptidase
HCC49_RS00770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCC49_RS00795	COG1122	ATPase activity
HCC49_RS00800	COG1122	ATPase activity
HCC49_RS00805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCC49_RS00825	COG2226	methyltransferase
HCC49_RS00830	COG2318	DinB family
HCC49_RS00840	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS00845	COG0489	protein tyrosine kinase activity
HCC49_RS00855	COG2194	sulfuric ester hydrolase activity
HCC49_RS00860	COG0726	polysaccharide deacetylase
HCC49_RS00910	COG0738	Major facilitator superfamily
HCC49_RS00915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS00930	COG0659	secondary active sulfate transmembrane transporter activity
HCC49_RS00935	COG0385	Bile acid
HCC49_RS00940	COG2819	hydrolase of the alpha beta superfamily
HCC49_RS00945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS00950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS00955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCC49_RS00960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCC49_RS00960	COG2207	Transcriptional regulator
HCC49_RS00965	COG3876	Protein conserved in bacteria
HCC49_RS00970	COG1472	Belongs to the glycosyl hydrolase 3 family
HCC49_RS00975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCC49_RS00980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS00980	COG1263	PTS System
HCC49_RS00990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCC49_RS00995	COG1683	Conserved Protein
HCC49_RS01025	COG1595	DNA-templated transcription, initiation
HCC49_RS01030	COG5662	AntiSigma factor
HCC49_RS01035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCC49_RS01040	COG4856	YbbR-like protein
HCC49_RS01080	COG1346	cytolysis
HCC49_RS01085	COG1380	Effector of murein hydrolase LrgA
HCC49_RS01090	COG1846	Transcriptional regulator
HCC49_RS01095	COG1113	amino acid transport
HCC49_RS01100	COG1011	Hydrolase
HCC49_RS01105	COG4585	Histidine kinase
HCC49_RS01110	COG2197	response regulator
HCC49_RS01115	COG1131	(ABC) transporter
HCC49_RS01155	COG0531	amino acid
HCC49_RS01160	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HCC49_RS01175	COG0584	glycerophosphoryl diester phosphodiesterase
HCC49_RS01180	COG2271	Major facilitator Superfamily
HCC49_RS01190	COG2368	4-hydroxyphenylacetate
HCC49_RS01200	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS01215	COG0371	Dehydrogenase
HCC49_RS01225	COG1183	phosphatidylcholine synthase activity
HCC49_RS01230	COG0586	Pfam SNARE associated Golgi protein
HCC49_RS01235	COG0688	phosphatidylethanolamine metabolic process
HCC49_RS01250	COG1301	dicarboxylic acid transport
HCC49_RS01255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS01260	COG0833	amino acid
HCC49_RS01265	COG2040	homocysteine
HCC49_RS01270	COG1115	amino acid carrier protein
HCC49_RS01275	COG2066	Belongs to the glutaminase family
HCC49_RS01280	COG4191	Histidine kinase
HCC49_RS01285	COG0784	Response regulator, receiver
HCC49_RS01290	COG3173	Aminoglycoside phosphotransferase
HCC49_RS01300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCC49_RS01305	COG0778	Nitroreductase
HCC49_RS01310	COG0346	lactoylglutathione lyase activity
HCC49_RS01315	COG2259	Doxx family
HCC49_RS01320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS01335	COG3773	Cell wall hydrolase
HCC49_RS01340	COG3540	Alkaline phosphatase
HCC49_RS01345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCC49_RS01350	COG0805	protein transport
HCC49_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCC49_RS01365	COG0477	Major facilitator Superfamily
HCC49_RS01370	COG1309	transcriptional regulator
HCC49_RS01375	COG0252	asparaginase activity
HCC49_RS01380	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCC49_RS01385	COG3012	SEC-C Motif Domain Protein
HCC49_RS01385	COG1405	negative regulation of cell septum assembly
HCC49_RS01390	COG0667	Aldo Keto reductase
HCC49_RS01400	COG1595	DNA-templated transcription, initiation
HCC49_RS01405	COG1595	DNA-templated transcription, initiation
HCC49_RS01410	COG1876	peptidase activity
HCC49_RS01415	COG0457	Tetratricopeptide repeat
HCC49_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS01425	COG0366	Alpha amylase catalytic
HCC49_RS01430	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCC49_RS01435	COG1121	(ABC) transporter
HCC49_RS01440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCC49_RS01445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS01450	COG2310	stress, protein
HCC49_RS01455	COG2310	stress, protein
HCC49_RS01460	COG2310	stress, protein
HCC49_RS01465	COG0861	Integral membrane protein TerC family
HCC49_RS01475	COG3853	Toxic anion resistance protein (TelA)
HCC49_RS01480	COG0477	Major facilitator Superfamily
HCC49_RS01485	COG2814	Major facilitator Superfamily
HCC49_RS01490	COG0640	Transcriptional regulator
HCC49_RS01495	COG4175	Glycine betaine
HCC49_RS01495	COG0517	IMP dehydrogenase activity
HCC49_RS01500	COG4176	ABC-type proline glycine betaine transport system permease component
HCC49_RS01505	COG2113	Glycine betaine
HCC49_RS01510	COG1473	amidohydrolase
HCC49_RS01515	COG1288	antiporter activity
HCC49_RS01525	COG0366	Alpha amylase catalytic
HCC49_RS01535	COG2814	Major facilitator Superfamily
HCC49_RS01540	COG1846	Transcriptional regulator
HCC49_RS01545	COG1280	lysine exporter protein (LysE YggA)
HCC49_RS01550	COG3403	YqcI/YcgG family
HCC49_RS01555	COG1113	amino acid transport
HCC49_RS01560	COG3665	Urea carboxylase-associated protein
HCC49_RS01575	COG1660	Displays ATPase and GTPase activities
HCC49_RS01585	COG2271	Major facilitator Superfamily
HCC49_RS01590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCC49_RS01595	COG3458	cephalosporin-C deacetylase activity
HCC49_RS01600	COG3541	Predicted nucleotidyltransferase
HCC49_RS01605	COG0506	proline dehydrogenase activity
HCC49_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS01615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCC49_RS01620	COG2508	Transcriptional regulator
HCC49_RS01630	COG1587	Uroporphyrinogen-III synthase
HCC49_RS01630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCC49_RS01635	COG2146	nitrite reductase [NAD(P)H] activity
HCC49_RS01640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCC49_RS01645	COG0523	cobalamin synthesis protein
HCC49_RS01650	COG1063	alcohol dehydrogenase
HCC49_RS01655	COG1714	RDD family
HCC49_RS01675	COG3209	COG3209 Rhs family protein
HCC49_RS01680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCC49_RS01685	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HCC49_RS01690	COG1733	regulation of RNA biosynthetic process
HCC49_RS01695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS01700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS01705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS01710	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HCC49_RS01725	COG2364	Membrane
HCC49_RS01730	COG1126	abc transporter atp-binding protein
HCC49_RS01735	COG0765	amino acid transport
HCC49_RS01740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS01745	COG0583	DNA-binding transcription factor activity
HCC49_RS01750	COG0163	prenyltransferase activity
HCC49_RS01755	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCC49_RS01770	COG3104	oligopeptide transport
HCC49_RS01775	COG5434	Belongs to the glycosyl hydrolase 28 family
HCC49_RS01785	COG0697	spore germination
HCC49_RS01795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCC49_RS01800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS01805	COG0456	acetyltransferase
HCC49_RS01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS01815	COG0765	amino acid transport
HCC49_RS01820	COG1126	abc transporter atp-binding protein
HCC49_RS01825	COG1473	amidohydrolase
HCC49_RS01830	COG2079	MmgE PrpD family protein
HCC49_RS01835	COG1136	(ABC) transporter
HCC49_RS01840	COG0577	efflux transmembrane transporter activity
HCC49_RS01845	COG0745	RESPONSE REGULATOR receiver
HCC49_RS01850	COG3850	Histidine kinase
HCC49_RS01850	COG5002	protein histidine kinase activity
HCC49_RS01855	COG0457	Tetratricopeptide repeat
HCC49_RS01870	COG0527	aspartate kinase activity
HCC49_RS01875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS01880	COG4605	iron ion homeostasis
HCC49_RS01885	COG4604	ABC transporter, ATP-binding protein
HCC49_RS01890	COG4607	ABC-type enterochelin transport system periplasmic component
HCC49_RS01895	COG2814	Major facilitator Superfamily
HCC49_RS01900	COG1309	transcriptional regulator
HCC49_RS01905	COG0778	Nitroreductase
HCC49_RS01910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCC49_RS01915	COG0640	Transcriptional regulator
HCC49_RS01920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS01935	COG4975	Glucose uptake
HCC49_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS01945	COG4549	nuclear export factor GLE1
HCC49_RS01950	COG1276	copper resistance
HCC49_RS01950	COG2372	response to copper ion
HCC49_RS01955	COG1349	DNA-binding transcription factor activity
HCC49_RS01965	COG2213	PTS system mannitol-specific
HCC49_RS01970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS01980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCC49_RS01990	COG0561	phosphatase activity
HCC49_RS02000	COG1914	H( )-stimulated, divalent metal cation uptake system
HCC49_RS02010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCC49_RS02015	COG1984	allophanate hydrolase subunit 2
HCC49_RS02020	COG1414	Transcriptional regulator
HCC49_RS02025	COG2755	lipolytic protein G-D-S-L family
HCC49_RS02035	COG2329	Antibiotic biosynthesis monooxygenase
HCC49_RS02040	COG0768	penicillin binding
HCC49_RS02045	COG4989	oxidoreductase activity
HCC49_RS02050	COG3711	transcriptional antiterminator
HCC49_RS02055	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS02065	COG1917	Cupin 2, conserved barrel domain protein
HCC49_RS02070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCC49_RS02075	COG3871	stress protein (general stress protein 26)
HCC49_RS02085	COG2814	Major facilitator Superfamily
HCC49_RS02090	COG1522	sequence-specific DNA binding
HCC49_RS02095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCC49_RS02095	COG0551	DNA topoisomerase type I activity
HCC49_RS02100	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCC49_RS02105	COG3706	GGDEF domain
HCC49_RS02110	COG5298	Protein conserved in bacteria
HCC49_RS02115	COG1215	transferase activity, transferring glycosyl groups
HCC49_RS02125	COG0531	amino acid
HCC49_RS02130	COG0494	nUDIX hydrolase
HCC49_RS02135	COG0028	Belongs to the TPP enzyme family
HCC49_RS02165	COG1914	H( )-stimulated, divalent metal cation uptake system
HCC49_RS02175	COG4876	unkown
HCC49_RS02185	COG2076	Multidrug Resistance protein
HCC49_RS02190	COG2217	Heavy metal translocating P-type atpase
HCC49_RS02195	COG3729	General stress protein
HCC49_RS02200	COG0662	Cupin 2, conserved barrel domain protein
HCC49_RS02205	COG2329	Antibiotic biosynthesis monooxygenase
HCC49_RS02210	COG3546	catalase activity
HCC49_RS02215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCC49_RS02220	COG3290	protein histidine kinase activity
HCC49_RS02225	COG4565	transcriptional regulatory protein
HCC49_RS02230	COG1301	dicarboxylic acid transport
HCC49_RS02235	COG0628	permease
HCC49_RS02240	COG1131	(ABC) transporter
HCC49_RS02245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCC49_RS02255	COG1960	acyl-CoA dehydrogenase activity
HCC49_RS02270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCC49_RS02275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS02285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCC49_RS02290	COG0513	Belongs to the DEAD box helicase family
HCC49_RS02295	COG3402	PFAM membrane-flanked domain
HCC49_RS02300	COG3428	Bacterial PH domain
HCC49_RS02305	COG0705	Rhomboid family
HCC49_RS02315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCC49_RS02320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCC49_RS02325	COG0864	Transcriptional regulator
HCC49_RS02330	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCC49_RS02335	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS02340	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS02345	COG2172	sigma factor antagonist activity
HCC49_RS02350	COG2208	phosphoserine phosphatase activity
HCC49_RS02355	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS02365	COG1191	sigma factor activity
HCC49_RS02370	COG2208	phosphoserine phosphatase activity
HCC49_RS02375	COG2183	response to ionizing radiation
HCC49_RS02445	COG0477	Major facilitator Superfamily
HCC49_RS02455	COG1764	response to oxidative stress
HCC49_RS02460	COG1846	Transcriptional regulator
HCC49_RS02470	COG1959	2 iron, 2 sulfur cluster binding
HCC49_RS02475	COG2910	NAD(P)H-binding
HCC49_RS02480	COG1278	Cold shock
HCC49_RS02485	COG1329	Transcriptional regulator
HCC49_RS02490	COG1794	racemase activity, acting on amino acids and derivatives
HCC49_RS02505	COG0456	acetyltransferase
HCC49_RS02505	COG1846	Transcriptional regulator
HCC49_RS02510	COG2271	Major facilitator Superfamily
HCC49_RS02515	COG3621	Patatin-like phospholipase
HCC49_RS02525	COG0662	Cupin 2, conserved barrel domain protein
HCC49_RS02540	COG0277	FAD linked oxidase domain protein
HCC49_RS02560	COG0662	Cupin 2, conserved barrel domain protein
HCC49_RS02565	COG2318	DinB family
HCC49_RS02570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCC49_RS02595	COG0351	phosphomethylpyrimidine kinase
HCC49_RS02610	COG1064	alcohol dehydrogenase
HCC49_RS02615	COG0789	Transcriptional regulator
HCC49_RS02625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS02660	COG2814	Major facilitator Superfamily
HCC49_RS02665	COG1309	transcriptional regulator
HCC49_RS02670	COG0697	spore germination
HCC49_RS02675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS02680	COG5577	PFAM Coat F domain
HCC49_RS02690	COG1063	alcohol dehydrogenase
HCC49_RS02695	COG5577	PFAM Coat F domain
HCC49_RS02710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCC49_RS02720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCC49_RS02725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS02735	COG2814	Major facilitator Superfamily
HCC49_RS02740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCC49_RS02750	COG0730	response to heat
HCC49_RS02755	COG0456	acetyltransferase
HCC49_RS02760	COG4978	Transcriptional regulator
HCC49_RS02760	COG0789	Transcriptional regulator
HCC49_RS02765	COG0697	spore germination
HCC49_RS02770	COG1051	belongs to the nudix hydrolase family
HCC49_RS02775	COG0596	Alpha beta hydrolase
HCC49_RS02780	COG0473	3-isopropylmalate dehydrogenase activity
HCC49_RS02785	COG1802	Transcriptional regulator
HCC49_RS02790	COG1819	glycosyl
HCC49_RS02805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCC49_RS02815	COG1388	LysM domain
HCC49_RS02820	COG2814	Major facilitator Superfamily
HCC49_RS02825	COG2188	Transcriptional regulator
HCC49_RS02830	COG2186	Transcriptional regulator
HCC49_RS02835	COG2807	transmembrane transport
HCC49_RS02840	COG2076	Multidrug Resistance protein
HCC49_RS02845	COG2076	Multidrug Resistance protein
HCC49_RS02850	COG1309	transcriptional regulator
HCC49_RS02855	COG0531	amino acid
HCC49_RS02865	COG3832	glyoxalase III activity
HCC49_RS02870	COG0604	alcohol dehydrogenase
HCC49_RS02875	COG2814	Major facilitator Superfamily
HCC49_RS02905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCC49_RS02910	COG0802	atpase or kinase
HCC49_RS02915	COG1214	PFAM Peptidase M22, glycoprotease
HCC49_RS02920	COG0456	acetyltransferase
HCC49_RS02925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCC49_RS02930	COG0488	(ABC) transporter
HCC49_RS02945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCC49_RS02950	COG0805	protein transport
HCC49_RS02960	COG1266	CAAX protease self-immunity
HCC49_RS02990	COG0732	type I restriction modification DNA specificity domain
HCC49_RS03000	COG0457	Tetratricopeptide repeat
HCC49_RS03005	COG1063	alcohol dehydrogenase
HCC49_RS03010	COG2211	Major facilitator Superfamily
HCC49_RS03015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCC49_RS03025	COG1842	Phage shock protein A
HCC49_RS03030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCC49_RS03035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HCC49_RS03040	COG4260	virion core protein, lumpy skin disease virus
HCC49_RS03045	COG2755	lipolytic protein G-D-S-L family
HCC49_RS03045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCC49_RS03055	COG1595	DNA-templated transcription, initiation
HCC49_RS03060	COG1063	alcohol dehydrogenase
HCC49_RS03065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCC49_RS03070	COG0823	Involved in the tonB-independent uptake of proteins
HCC49_RS03085	COG2132	Multicopper oxidase
HCC49_RS03090	COG1113	amino acid transport
HCC49_RS03095	COG0714	Associated with various cellular activities
HCC49_RS03100	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HCC49_RS03105	COG1305	Transglutaminase-like
HCC49_RS03145	COG2252	PERMEase
HCC49_RS03150	COG3064	Membrane
HCC49_RS03170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCC49_RS03175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCC49_RS03180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCC49_RS03185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCC49_RS03190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCC49_RS03205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCC49_RS03215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCC49_RS03220	COG0138	bifunctional purine biosynthesis protein purh
HCC49_RS03225	COG0151	Belongs to the GarS family
HCC49_RS03235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCC49_RS03240	COG1470	cell adhesion involved in biofilm formation
HCC49_RS03245	COG4496	protein, YerC YecD
HCC49_RS03250	COG0069	glutamate synthase activity
HCC49_RS03265	COG0210	DNA helicase
HCC49_RS03275	COG4851	CamS sex pheromone cAM373 precursor
HCC49_RS03280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCC49_RS03285	COG1285	pathogenesis
HCC49_RS03290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCC49_RS03310	COG1309	transcriptional regulator
HCC49_RS03315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCC49_RS03320	COG1597	lipid kinase activity
HCC49_RS03325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCC49_RS03330	COG2197	response regulator
HCC49_RS03340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS03350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCC49_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS03365	COG1131	(ABC) transporter
HCC49_RS03420	COG3546	catalase activity
HCC49_RS03425	COG0454	-acetyltransferase
HCC49_RS03435	COG2323	membrane
HCC49_RS03440	COG2329	Antibiotic biosynthesis monooxygenase
HCC49_RS03445	COG0346	lactoylglutathione lyase activity
HCC49_RS03450	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS03455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCC49_RS03460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCC49_RS03465	COG4208	sulfate ABC transporter
HCC49_RS03475	COG5583	Uncharacterized small protein (DUF2292)
HCC49_RS03480	COG0196	riboflavin kinase activity
HCC49_RS03485	COG0670	Belongs to the BI1 family
HCC49_RS03500	COG2124	cytochrome p450
HCC49_RS03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCC49_RS03515	COG1131	(ABC) transporter
HCC49_RS03560	COG4106	trans-aconitate 2-methyltransferase activity
HCC49_RS03565	COG1368	sulfuric ester hydrolase activity
HCC49_RS03570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCC49_RS03575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS03580	COG1442	glycosyl transferase family 8
HCC49_RS03585	COG1216	Glycosyl transferase, family 2
HCC49_RS03590	COG1442	glycosyl transferase family 8
HCC49_RS03595	COG2223	nitrite transmembrane transporter activity
HCC49_RS03600	COG0531	amino acid
HCC49_RS03605	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS03610	COG0840	transmembrane signaling receptor activity
HCC49_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS03620	COG0463	Glycosyl transferase, family 2
HCC49_RS03620	COG0457	Tetratricopeptide repeat
HCC49_RS03625	COG0488	(ABC) transporter
HCC49_RS03630	COG0789	Transcriptional regulator
HCC49_RS03635	COG2814	Major facilitator Superfamily
HCC49_RS03640	COG0488	(ABC) transporter
HCC49_RS03645	COG0513	Belongs to the DEAD box helicase family
HCC49_RS03650	COG0456	acetyltransferase
HCC49_RS03655	COG2130	NADP-dependent
HCC49_RS03670	COG3866	Pectate lyase
HCC49_RS03675	COG0471	metal ion transport
HCC49_RS03695	COG3290	protein histidine kinase activity
HCC49_RS03700	COG4565	transcriptional regulatory protein
HCC49_RS03705	COG3181	Tripartite tricarboxylate transporter family receptor
HCC49_RS03710	COG2851	Citrate transporter
HCC49_RS03715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS03720	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCC49_RS03730	COG2258	MOSC domain
HCC49_RS03750	COG0024	Methionine aminopeptidase
HCC49_RS03755	COG1263	PTS System
HCC49_RS03755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS03765	COG1368	sulfuric ester hydrolase activity
HCC49_RS03775	COG0071	Belongs to the small heat shock protein (HSP20) family
HCC49_RS03790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS03790	COG1263	PTS System
HCC49_RS03795	COG0366	Alpha amylase catalytic
HCC49_RS03800	COG2188	Transcriptional regulator
HCC49_RS03805	COG0778	Nitroreductase
HCC49_RS03820	COG0737	Belongs to the 5'-nucleotidase family
HCC49_RS03825	COG0693	protein deglycase activity
HCC49_RS03830	COG1609	Transcriptional regulator
HCC49_RS03845	COG2814	Major facilitator Superfamily
HCC49_RS03855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCC49_RS03860	COG4980	gas vesicle protein
HCC49_RS03865	COG1295	ribonuclease BN
HCC49_RS03875	COG0477	Major facilitator Superfamily
HCC49_RS03880	COG0387	Pfam Sodium calcium exchanger
HCC49_RS03890	COG0668	transmembrane transport
HCC49_RS03895	COG0535	radical SAM domain protein
HCC49_RS03905	COG0726	polysaccharide deacetylase
HCC49_RS03910	COG2084	Dehydrogenase
HCC49_RS03920	COG0598	Magnesium transport protein CorA
HCC49_RS03925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCC49_RS03930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCC49_RS03940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCC49_RS03945	COG4637	Psort location Cytoplasmic, score
HCC49_RS03950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCC49_RS03955	COG0022	dehydrogenase e1 component
HCC49_RS03960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCC49_RS03965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCC49_RS03970	COG3284	Transcriptional regulator
HCC49_RS03980	COG1486	melibiose metabolic process
HCC49_RS03985	COG1737	Transcriptional regulator
HCC49_RS03990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS03990	COG1263	PTS System
HCC49_RS03995	COG1132	(ABC) transporter
HCC49_RS04000	COG1132	(ABC) transporter
HCC49_RS04005	COG2259	Doxx family
HCC49_RS04010	COG2514	catechol 2,3-dioxygenase activity
HCC49_RS04020	COG1695	Transcriptional regulator
HCC49_RS04025	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCC49_RS04030	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HCC49_RS04035	COG0574	Belongs to the PEP-utilizing enzyme family
HCC49_RS04035	COG3848	Pyruvate phosphate dikinase
HCC49_RS04040	COG2732	(Barnase) inhibitor
HCC49_RS04045	COG2318	DinB family
HCC49_RS04050	COG2814	Major facilitator Superfamily
HCC49_RS04055	COG1846	Transcriptional regulator
HCC49_RS04060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCC49_RS04060	COG0392	lysyltransferase activity
HCC49_RS04065	COG0384	phenazine biosynthesis protein PhzF
HCC49_RS04070	COG0778	Nitroreductase
HCC49_RS04085	COG1090	epimerase
HCC49_RS04100	COG2814	Major facilitator Superfamily
HCC49_RS04110	COG3591	Belongs to the peptidase S1B family
HCC49_RS04125	COG3103	Sh3 type 3 domain protein
HCC49_RS04130	COG5658	integral membrane protein
HCC49_RS04135	COG0596	Alpha beta hydrolase
HCC49_RS04140	COG0463	Glycosyl transferase, family 2
HCC49_RS04145	COG4485	Bacterial membrane protein, YfhO
HCC49_RS04150	COG1988	membrane-bound metal-dependent
HCC49_RS04155	COG1194	a g-specific adenine glycosylase
HCC49_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS04185	COG1132	(ABC) transporter
HCC49_RS04190	COG4129	membrane
HCC49_RS04200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCC49_RS04205	COG0735	belongs to the Fur family
HCC49_RS04330	COG0277	FAD linked oxidase domain protein
HCC49_RS04340	COG0747	negative chemotaxis
HCC49_RS04345	COG0601	transmembrane transport
HCC49_RS04350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCC49_RS04355	COG0444	Belongs to the ABC transporter superfamily
HCC49_RS04360	COG4608	Belongs to the ABC transporter superfamily
HCC49_RS04365	COG0753	catalase activity
HCC49_RS04375	COG1116	anion transmembrane transporter activity
HCC49_RS04380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCC49_RS04385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCC49_RS04405	COG1476	TRANSCRIPTIONal
HCC49_RS04415	COG3382	B3 4 domain protein
HCC49_RS04420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCC49_RS04430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCC49_RS04435	COG0789	Transcriptional regulator
HCC49_RS04440	COG1664	Polymer-forming cytoskeletal
HCC49_RS04445	COG1664	Polymer-forming cytoskeletal
HCC49_RS04450	COG2766	serine protein kinase
HCC49_RS04460	COG1846	Transcriptional regulator
HCC49_RS04465	COG1566	PFAM secretion protein HlyD family protein
HCC49_RS04470	COG2814	Major facilitator Superfamily
HCC49_RS04475	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCC49_RS04490	COG1725	Transcriptional regulator
HCC49_RS04495	COG1131	(ABC) transporter
HCC49_RS04500	COG1131	(ABC) transporter
HCC49_RS04505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCC49_RS04510	COG1278	Cold shock
HCC49_RS04515	COG1464	Belongs to the NlpA lipoprotein family
HCC49_RS04520	COG3706	GGDEF domain
HCC49_RS04525	COG1823	symporter activity
HCC49_RS04545	COG5577	PFAM Coat F domain
HCC49_RS04550	COG4085	toxin activity
HCC49_RS04550	COG1525	nuclease
HCC49_RS04550	COG0737	Belongs to the 5'-nucleotidase family
HCC49_RS04555	COG3764	Sortase (surface protein transpeptidase)
HCC49_RS04560	COG0564	pseudouridine synthase activity
HCC49_RS04570	COG0517	IMP dehydrogenase activity
HCC49_RS04575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCC49_RS04580	COG3153	acetyltransferase
HCC49_RS04580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCC49_RS04585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCC49_RS04590	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HCC49_RS04595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCC49_RS04605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCC49_RS04610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCC49_RS04615	COG4585	Histidine kinase
HCC49_RS04615	COG2203	Gaf domain
HCC49_RS04620	COG2197	response regulator
HCC49_RS04625	COG0431	NADPH-dependent FMN reductase
HCC49_RS04640	COG0791	NLP P60 protein
HCC49_RS04640	COG1388	LysM domain
HCC49_RS04645	COG1959	2 iron, 2 sulfur cluster binding
HCC49_RS04650	COG0668	transmembrane transport
HCC49_RS04655	COG2719	SpoVR family
HCC49_RS04660	COG1785	Belongs to the alkaline phosphatase family
HCC49_RS04665	COG0791	NLP P60 protein
HCC49_RS04665	COG1388	LysM domain
HCC49_RS04670	COG0583	DNA-binding transcription factor activity
HCC49_RS04675	COG0372	Belongs to the citrate synthase family
HCC49_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS04685	COG0531	amino acid
HCC49_RS04690	COG0733	neurotransmitter:sodium symporter activity
HCC49_RS04705	COG1595	DNA-templated transcription, initiation
HCC49_RS04710	COG0204	Acyl-transferase
HCC49_RS04715	COG1253	flavin adenine dinucleotide binding
HCC49_RS04720	COG0789	Transcriptional regulator
HCC49_RS04725	COG0436	Aminotransferase
HCC49_RS04730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCC49_RS04735	COG1253	flavin adenine dinucleotide binding
HCC49_RS04740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCC49_RS04745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCC49_RS04750	COG0584	glycerophosphoryl diester phosphodiesterase
HCC49_RS04760	COG0668	transmembrane transport
HCC49_RS04765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCC49_RS04770	COG0726	polysaccharide deacetylase
HCC49_RS04775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS04780	COG3226	Transcriptional regulator
HCC49_RS04790	COG0589	response to stress
HCC49_RS04795	COG1132	(ABC) transporter
HCC49_RS04800	COG1132	(ABC) transporter
HCC49_RS04805	COG0702	epimerase
HCC49_RS04820	COG0189	ligase activity
HCC49_RS04825	COG0189	ligase activity
HCC49_RS04840	COG4335	DNA alkylation repair
HCC49_RS04845	COG0561	phosphatase activity
HCC49_RS04850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCC49_RS04860	COG0475	glutathione-regulated potassium exporter activity
HCC49_RS04865	COG0490	domain, Protein
HCC49_RS04875	COG1024	Enoyl-CoA hydratase
HCC49_RS04885	COG4152	abc transporter atp-binding protein
HCC49_RS04890	COG1668	transmembrane transport
HCC49_RS04895	COG0420	3'-5' exonuclease activity
HCC49_RS04900	COG4717	serine-type aminopeptidase activity
HCC49_RS04915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCC49_RS04950	COG4980	gas vesicle protein
HCC49_RS04965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCC49_RS04970	COG0537	adenosine 5'-monophosphoramidase activity
HCC49_RS04975	COG1131	(ABC) transporter
HCC49_RS04980	COG4473	ABC transporter
HCC49_RS04990	COG1473	amidohydrolase
HCC49_RS04995	COG3069	C4-dicarboxylate transmembrane transporter activity
HCC49_RS05000	COG2329	Antibiotic biosynthesis monooxygenase
HCC49_RS05005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCC49_RS05025	COG1309	transcriptional regulator
HCC49_RS05030	COG1511	domain protein
HCC49_RS05035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCC49_RS05045	COG1363	Peptidase, m42
HCC49_RS05050	COG1301	dicarboxylic acid transport
HCC49_RS05060	COG1234	tRNA 3'-trailer cleavage
HCC49_RS05065	COG0095	Lipoate-protein ligase
HCC49_RS05070	COG0702	epimerase
HCC49_RS05075	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS05085	COG0501	Belongs to the peptidase M48B family
HCC49_RS05090	COG1404	Belongs to the peptidase S8 family
HCC49_RS05100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCC49_RS05105	COG0406	alpha-ribazole phosphatase activity
HCC49_RS05110	COG0183	Belongs to the thiolase family
HCC49_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS05120	COG1268	BioY protein
HCC49_RS05125	COG0840	transmembrane signaling receptor activity
HCC49_RS05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCC49_RS05130	COG0723	plastoquinol--plastocyanin reductase activity
HCC49_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS05145	COG4903	ComK protein
HCC49_RS05155	COG5646	InterPro IPR014922
HCC49_RS05175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCC49_RS05190	COG0398	Pfam SNARE associated Golgi protein
HCC49_RS05195	COG0681	Belongs to the peptidase S26 family
HCC49_RS05200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCC49_RS05205	COG1846	Transcriptional regulator
HCC49_RS05210	COG3180	Ammonia monooxygenase
HCC49_RS05215	COG2814	Major facilitator Superfamily
HCC49_RS05225	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCC49_RS05230	COG2323	membrane
HCC49_RS05245	COG0420	3'-5' exonuclease activity
HCC49_RS05250	COG0419	ATPase involved in DNA repair
HCC49_RS05255	COG1403	HNH endonuclease
HCC49_RS05295	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCC49_RS05310	COG0367	asparagine synthase
HCC49_RS05315	COG1562	ergosterol biosynthetic process
HCC49_RS05320	COG0534	Mate efflux family protein
HCC49_RS05325	COG1917	Cupin 2, conserved barrel domain protein
HCC49_RS05325	COG2207	Transcriptional regulator
HCC49_RS05330	COG1609	Transcriptional regulator
HCC49_RS05335	COG0673	inositol 2-dehydrogenase activity
HCC49_RS05340	COG2318	DinB family
HCC49_RS05345	COG1279	arginine transmembrane transporter activity
HCC49_RS05350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS05355	COG1357	PFAM Pentapeptide repeats (8 copies)
HCC49_RS05360	COG2153	protein acetylation
HCC49_RS05365	COG0646	methionine synthase
HCC49_RS05365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCC49_RS05375	COG2996	Protein conserved in bacteria
HCC49_RS05385	COG0840	transmembrane signaling receptor activity
HCC49_RS05395	COG1307	EDD domain protein, DegV family
HCC49_RS05400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS05420	COG0561	phosphatase activity
HCC49_RS05425	COG1073	alpha beta
HCC49_RS05430	COG2151	metal-sulfur cluster biosynthetic enzyme
HCC49_RS05440	COG0277	FAD linked oxidase domain protein
HCC49_RS05445	COG2271	Major facilitator Superfamily
HCC49_RS05455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCC49_RS05465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCC49_RS05470	COG0505	Belongs to the CarA family
HCC49_RS05475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCC49_RS05480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCC49_RS05495	COG2267	carboxylic ester hydrolase activity
HCC49_RS05505	COG1744	ABC transporter substrate-binding protein PnrA-like
HCC49_RS05520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCC49_RS05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCC49_RS05530	COG5504	Zn-dependent protease
HCC49_RS05535	COG0444	Belongs to the ABC transporter superfamily
HCC49_RS05540	COG4608	Belongs to the ABC transporter superfamily
HCC49_RS05550	COG0601	transmembrane transport
HCC49_RS05555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCC49_RS05565	COG0180	Tryptophanyl-tRNA synthetase
HCC49_RS05570	COG4166	transmembrane transport
HCC49_RS05575	COG0601	transmembrane transport
HCC49_RS05580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCC49_RS05585	COG0444	Belongs to the ABC transporter superfamily
HCC49_RS05590	COG4608	Belongs to the ABC transporter superfamily
HCC49_RS05600	COG0456	acetyltransferase
HCC49_RS05605	COG1393	Belongs to the ArsC family
HCC49_RS05610	COG0861	Integral membrane protein TerC family
HCC49_RS05615	COG4862	establishment of competence for transformation
HCC49_RS05620	COG4469	Competence protein
HCC49_RS05625	COG1164	Oligoendopeptidase f
HCC49_RS05640	COG2346	COG2346, Truncated hemoglobins
HCC49_RS05645	COG0741	lytic transglycosylase activity
HCC49_RS05650	COG4116	CYTH
HCC49_RS05660	COG2357	RelA SpoT domain protein
HCC49_RS05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCC49_RS05670	COG0564	pseudouridine synthase activity
HCC49_RS05680	COG0475	glutathione-regulated potassium exporter activity
HCC49_RS05680	COG0569	domain protein
HCC49_RS05685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCC49_RS05690	COG0352	thiamine-phosphate diphosphorylase activity
HCC49_RS05695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCC49_RS05700	COG2104	thiamine diphosphate biosynthetic process
HCC49_RS05710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCC49_RS05715	COG0351	phosphomethylpyrimidine kinase
HCC49_RS05720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCC49_RS05775	COG0210	DNA helicase
HCC49_RS05785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS05795	COG1131	(ABC) transporter
HCC49_RS05805	COG2153	protein acetylation
HCC49_RS05815	COG2382	esterase
HCC49_RS05820	COG0626	cystathionine gamma-synthase activity
HCC49_RS05825	COG0626	cystathionine gamma-synthase activity
HCC49_RS05850	COG2367	Beta-lactamase
HCC49_RS05855	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCC49_RS05860	COG0477	Major facilitator Superfamily
HCC49_RS05865	COG1846	Transcriptional regulator
HCC49_RS05875	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCC49_RS05880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCC49_RS05885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCC49_RS05890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS05890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS05895	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCC49_RS05905	COG1349	DNA-binding transcription factor activity
HCC49_RS05925	COG1285	pathogenesis
HCC49_RS05940	COG2205	protein histidine kinase activity
HCC49_RS05950	COG3383	formate dehydrogenase (NAD+) activity
HCC49_RS05955	COG2427	Protein of unknown function (DUF1641)
HCC49_RS05960	COG2124	cytochrome p450
HCC49_RS05965	COG1819	glycosyl
HCC49_RS05975	COG1587	Uroporphyrinogen-III synthase
HCC49_RS05980	COG0390	transport system, permease component
HCC49_RS05985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCC49_RS05990	COG0697	spore germination
HCC49_RS05995	COG4297	protein containing double-stranded beta helix domain
HCC49_RS06005	COG1252	NADH dehydrogenase
HCC49_RS06015	COG2211	Major facilitator Superfamily
HCC49_RS06020	COG1609	Transcriptional regulator
HCC49_RS06025	COG0246	Mannitol dehydrogenase
HCC49_RS06030	COG2721	sulfolactate sulfo-lyase activity
HCC49_RS06035	COG0730	response to heat
HCC49_RS06040	COG2318	DinB family
HCC49_RS06045	COG0457	Tetratricopeptide repeat
HCC49_RS06055	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS06055	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS06055	COG1388	LysM domain
HCC49_RS06065	COG4195	phage-related replication protein
HCC49_RS06070	COG2856	Zn peptidase
HCC49_RS06075	COG1396	sequence-specific DNA binding
HCC49_RS06085	COG1522	sequence-specific DNA binding
HCC49_RS06090	COG1484	DNA-dependent DNA replication
HCC49_RS06110	COG1595	DNA-templated transcription, initiation
HCC49_RS06115	COG5484	DNA packaging
HCC49_RS06115	COG3728	DNA packaging
HCC49_RS06120	COG1783	phage Terminase large subunit
HCC49_RS06125	COG5518	Phage portal protein
HCC49_RS06130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCC49_RS06135	COG4653	Phage capsid family
HCC49_RS06185	COG3953	SLT domain
HCC49_RS06185	COG5412	phage tail tape measure protein
HCC49_RS06185	COG5412	phage tail tape measure protein
HCC49_RS06185	COG3953	SLT domain
HCC49_RS06185	COG3953	SLT domain
HCC49_RS06185	COG5412	phage tail tape measure protein
HCC49_RS06190	COG1652	LysM domain
HCC49_RS06195	COG4193	domain, Protein
HCC49_RS06205	COG3628	GPW Gp25 family protein
HCC49_RS06210	COG3299	homolog of phage Mu protein gp47
HCC49_RS06215	COG3778	Protein conserved in bacteria
HCC49_RS06255	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS06255	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS06270	COG0306	phosphate transporter
HCC49_RS06275	COG1392	Phosphate transport regulator
HCC49_RS06280	COG0531	amino acid
HCC49_RS06285	COG0346	lactoylglutathione lyase activity
HCC49_RS06290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCC49_RS06295	COG0463	Glycosyl transferase, family 2
HCC49_RS06300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCC49_RS06305	COG0477	Major facilitator Superfamily
HCC49_RS06310	COG2362	D-Aminopeptidase
HCC49_RS06315	COG0601	transmembrane transport
HCC49_RS06320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCC49_RS06325	COG0444	Belongs to the ABC transporter superfamily
HCC49_RS06330	COG4166	transmembrane transport
HCC49_RS06335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCC49_RS06340	COG4948	Mandelate Racemase Muconate Lactonizing
HCC49_RS06345	COG0791	NLP P60 protein
HCC49_RS06350	COG4608	Belongs to the ABC transporter superfamily
HCC49_RS06355	COG2706	6-phosphogluconolactonase activity
HCC49_RS06360	COG1834	amidinotransferase
HCC49_RS06365	COG1607	acyl-coa hydrolase
HCC49_RS06370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCC49_RS06375	COG2076	Multidrug Resistance protein
HCC49_RS06380	COG2076	Multidrug Resistance protein
HCC49_RS06385	COG0788	formyltetrahydrofolate deformylase activity
HCC49_RS06390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCC49_RS06400	COG1764	response to oxidative stress
HCC49_RS06405	COG1846	Transcriptional regulator
HCC49_RS06410	COG1764	response to oxidative stress
HCC49_RS06425	COG0463	Glycosyl transferase, family 2
HCC49_RS06425	COG0457	Tetratricopeptide repeat
HCC49_RS06440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCC49_RS06450	COG1404	Belongs to the peptidase S8 family
HCC49_RS06455	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS06460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCC49_RS06465	COG1122	ATPase activity
HCC49_RS06470	COG4721	ABC-type cobalt transport system, permease component
HCC49_RS06475	COG3858	chitin binding
HCC49_RS06475	COG1388	LysM domain
HCC49_RS06490	COG2239	Acts as a magnesium transporter
HCC49_RS06495	COG0789	Transcriptional regulator
HCC49_RS06510	COG1846	Transcriptional regulator
HCC49_RS06515	COG0726	polysaccharide deacetylase
HCC49_RS06520	COG3285	dna ligase
HCC49_RS06520	COG1793	dna ligase
HCC49_RS06525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HCC49_RS06530	COG0586	Pfam SNARE associated Golgi protein
HCC49_RS06535	COG0861	Integral membrane protein TerC family
HCC49_RS06540	COG1191	sigma factor activity
HCC49_RS06565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCC49_RS06570	COG2323	membrane
HCC49_RS06580	COG3594	Acyltransferase
HCC49_RS06585	COG5002	protein histidine kinase activity
HCC49_RS06590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCC49_RS06605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCC49_RS06610	COG0436	Aminotransferase
HCC49_RS06640	COG3852	Histidine kinase
HCC49_RS06645	COG1846	Transcriptional regulator
HCC49_RS06650	COG1360	Flagellar Motor Protein
HCC49_RS06655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCC49_RS06660	COG0542	response to heat
HCC49_RS06665	COG3949	Membrane
HCC49_RS06680	COG0720	synthase
HCC49_RS06685	COG0602	queuosine metabolic process
HCC49_RS06710	COG4873	Protein conserved in bacteria
HCC49_RS06720	COG3773	Cell wall hydrolase
HCC49_RS06725	COG2244	polysaccharide biosynthetic process
HCC49_RS06730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS06735	COG2217	Heavy metal translocating P-type atpase
HCC49_RS06740	COG0006	proline dipeptidase activity
HCC49_RS06745	COG1609	Transcriptional regulator
HCC49_RS06750	COG3711	transcriptional antiterminator
HCC49_RS06755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS06755	COG1263	PTS System
HCC49_RS06755	COG2190	(PTS) system
HCC49_RS06760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCC49_RS06775	COG1533	DNA photolyase activity
HCC49_RS06780	COG0840	transmembrane signaling receptor activity
HCC49_RS06785	COG2084	Dehydrogenase
HCC49_RS06795	COG0347	Belongs to the P(II) protein family
HCC49_RS06800	COG2340	Cysteine-rich secretory protein family
HCC49_RS06805	COG0768	penicillin binding
HCC49_RS06810	COG4191	Histidine kinase
HCC49_RS06815	COG0436	Aminotransferase
HCC49_RS06825	COG0835	chemotaxis
HCC49_RS06825	COG0784	Response regulator, receiver
HCC49_RS06835	COG2814	Major facilitator Superfamily
HCC49_RS06840	COG1376	ErfK ybiS ycfS ynhG family protein
HCC49_RS06845	COG1408	metallophosphoesterase
HCC49_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS06860	COG2200	EAL domain
HCC49_RS06865	COG4703	Protein of unknown function (DUF1797)
HCC49_RS06870	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HCC49_RS06880	COG0517	IMP dehydrogenase activity
HCC49_RS06885	COG0583	DNA-binding transcription factor activity
HCC49_RS06890	COG0716	FMN binding
HCC49_RS06900	COG0716	FMN binding
HCC49_RS06920	COG0668	transmembrane transport
HCC49_RS06925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS06945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCC49_RS06950	COG0303	'Molybdopterin
HCC49_RS06955	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCC49_RS06960	COG0314	molybdopterin synthase activity
HCC49_RS06965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCC49_RS06975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCC49_RS06980	COG1136	(ABC) transporter
HCC49_RS06985	COG0577	efflux transmembrane transporter activity
HCC49_RS06990	COG1349	DNA-binding transcription factor activity
HCC49_RS06995	COG1105	Belongs to the carbohydrate kinase PfkB family
HCC49_RS07000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCC49_RS07000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCC49_RS07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS07005	COG0681	Belongs to the peptidase S26 family
HCC49_RS07015	COG0488	(ABC) transporter
HCC49_RS07020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCC49_RS07025	COG2309	aminopeptidase activity
HCC49_RS07035	COG1077	Cell shape determining protein MreB Mrl
HCC49_RS07040	COG2002	toxin-antitoxin pair type II binding
HCC49_RS07045	COG3852	Histidine kinase
HCC49_RS07050	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCC49_RS07050	COG2105	PFAM AIG2 family protein
HCC49_RS07055	COG0569	domain protein
HCC49_RS07065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCC49_RS07075	COG0561	phosphatase activity
HCC49_RS07080	COG0242	peptide deformylase activity
HCC49_RS07090	COG0497	DNA recombination
HCC49_RS07100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS07100	COG3321	synthase
HCC49_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS07100	COG4221	oxidoreductase activity
HCC49_RS07105	COG4221	oxidoreductase activity
HCC49_RS07105	COG3321	synthase
HCC49_RS07105	COG0300	oxidoreductase activity
HCC49_RS07105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS07110	COG4221	oxidoreductase activity
HCC49_RS07110	COG3321	synthase
HCC49_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS07110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS07115	COG3321	synthase
HCC49_RS07115	COG0300	oxidoreductase activity
HCC49_RS07115	COG4221	oxidoreductase activity
HCC49_RS07115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS07120	COG0300	oxidoreductase activity
HCC49_RS07120	COG4221	oxidoreductase activity
HCC49_RS07120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS07120	COG3321	synthase
HCC49_RS07125	COG4221	oxidoreductase activity
HCC49_RS07125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS07125	COG3321	synthase
HCC49_RS07125	COG0300	oxidoreductase activity
HCC49_RS07130	COG4221	oxidoreductase activity
HCC49_RS07130	COG3321	synthase
HCC49_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS07130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS07135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCC49_RS07140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCC49_RS07145	COG0022	dehydrogenase e1 component
HCC49_RS07150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCC49_RS07155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCC49_RS07160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS07175	COG1982	Orn Lys Arg decarboxylase major
HCC49_RS07195	COG0483	inositol monophosphate 1-phosphatase activity
HCC49_RS07205	COG3227	Zinc metalloprotease (Elastase)
HCC49_RS07220	COG1595	DNA-templated transcription, initiation
HCC49_RS07250	COG4896	Protein conserved in bacteria
HCC49_RS07260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCC49_RS07265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCC49_RS07270	COG2066	Belongs to the glutaminase family
HCC49_RS07280	COG0772	Belongs to the SEDS family
HCC49_RS07285	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HCC49_RS07300	COG2010	Cytochrome c
HCC49_RS07300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCC49_RS07305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCC49_RS07310	COG1845	cytochrome c oxidase, subunit III
HCC49_RS07315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCC49_RS07320	COG3336	cytochrome c oxidase
HCC49_RS07330	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HCC49_RS07335	COG2340	Cysteine-rich secretory protein family
HCC49_RS07350	COG3679	Belongs to the UPF0342 family
HCC49_RS07365	COG0742	ribosomal rna small subunit methyltransferase
HCC49_RS07375	COG3314	Sporulation integral membrane protein YlbJ
HCC49_RS07380	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCC49_RS07385	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCC49_RS07395	COG1399	metal-binding, possibly nucleic acid-binding protein
HCC49_RS07415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCC49_RS07435	COG4839	cell division protein FtsL
HCC49_RS07445	COG0768	penicillin binding
HCC49_RS07465	COG0772	Belongs to the SEDS family
HCC49_RS07480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCC49_RS07485	COG0849	cell division
HCC49_RS07490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCC49_RS07495	COG1404	Belongs to the peptidase S8 family
HCC49_RS07495	COG4412	M6 family metalloprotease domain protein
HCC49_RS07505	COG1191	sigma factor activity
HCC49_RS07510	COG1191	sigma factor activity
HCC49_RS07515	COG1119	ATPase activity
HCC49_RS07520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCC49_RS07525	COG1873	PFAM PRC-barrel domain
HCC49_RS07535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCC49_RS07545	COG0762	integral membrane protein
HCC49_RS07550	COG2302	S4 RNA-binding domain
HCC49_RS07555	COG3599	regulation of cell shape
HCC49_RS07560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCC49_RS07565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCC49_RS07575	COG0564	pseudouridine synthase activity
HCC49_RS07585	COG2233	PERMEase
HCC49_RS07595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCC49_RS07600	COG0505	Belongs to the CarA family
HCC49_RS07605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCC49_RS07620	COG0284	orotidine-5'-phosphate decarboxylase activity
HCC49_RS07625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCC49_RS07635	COG0306	phosphate transporter
HCC49_RS07650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCC49_RS07655	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HCC49_RS07660	COG1648	precorrin-2 dehydrogenase activity
HCC49_RS07675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCC49_RS07680	COG1561	YicC-like family, N-terminal region
HCC49_RS07690	COG0194	GDP metabolic process
HCC49_RS07700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCC49_RS07705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCC49_RS07710	COG0242	peptide deformylase activity
HCC49_RS07720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCC49_RS07720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCC49_RS07730	COG0631	protein serine/threonine phosphatase activity
HCC49_RS07735	COG2815	serine threonine protein kinase
HCC49_RS07735	COG0515	serine threonine protein kinase
HCC49_RS07745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCC49_RS07750	COG1564	THIamine pyrophosphokinase
HCC49_RS07765	COG1302	Protein conserved in bacteria
HCC49_RS07770	COG1461	Dihydroxyacetone kinase
HCC49_RS07775	COG1760	l-serine dehydratase
HCC49_RS07780	COG1760	l-serine dehydratase
HCC49_RS07785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCC49_RS07800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCC49_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS07820	COG1196	nuclear chromosome segregation
HCC49_RS07825	COG0552	protein localization to endoplasmic reticulum
HCC49_RS07840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCC49_RS07850	COG1837	Belongs to the UPF0109 family
HCC49_RS07875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCC49_RS07890	COG2257	FlhB HrpN YscU SpaS Family
HCC49_RS07900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCC49_RS07905	COG0758	DNA mediated transformation
HCC49_RS07910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCC49_RS07920	COG4974	Belongs to the 'phage' integrase family
HCC49_RS07940	COG1815	bacterial-type flagellum-dependent cell motility
HCC49_RS07945	COG1558	bacterial-type flagellum-dependent cell motility
HCC49_RS07950	COG1677	Flagellar hook-basal body complex protein FliE
HCC49_RS07955	COG1766	The M ring may be actively involved in energy transduction
HCC49_RS07960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCC49_RS07965	COG1317	bacterial-type flagellum organization
HCC49_RS07970	COG1157	protein secretion by the type III secretion system
HCC49_RS07975	COG2882	bacterial-type flagellum organization
HCC49_RS07980	COG3334	PFAM MgtE intracellular
HCC49_RS07985	COG3144	bacterial-type flagellum assembly
HCC49_RS07990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HCC49_RS07995	COG4786	Flagellar basal body rod
HCC49_RS08000	COG1582	Flagellar protein (FlbD)
HCC49_RS08005	COG1580	Controls the rotational direction of flagella during chemotaxis
HCC49_RS08010	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCC49_RS08015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCC49_RS08015	COG1776	CheC inhibitor of MCP methylation
HCC49_RS08020	COG2201	protein-glutamate methylesterase activity
HCC49_RS08025	COG3190	flagellar
HCC49_RS08030	COG1338	Plays a role in the flagellum-specific transport system
HCC49_RS08035	COG1987	bacterial-type flagellum assembly
HCC49_RS08040	COG1684	flagellar biosynthetic protein fliR
HCC49_RS08045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCC49_RS08050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCC49_RS08055	COG1419	protein localization to endoplasmic reticulum
HCC49_RS08060	COG0455	bacterial-type flagellum organization
HCC49_RS08065	COG2201	protein-glutamate methylesterase activity
HCC49_RS08070	COG2198	Histidine kinase
HCC49_RS08070	COG0643	Histidine kinase
HCC49_RS08075	COG0835	chemotaxis
HCC49_RS08080	COG1776	CheC inhibitor of MCP methylation
HCC49_RS08090	COG1191	sigma factor activity
HCC49_RS08120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCC49_RS08125	COG4589	Belongs to the CDS family
HCC49_RS08135	COG0750	zinc metalloprotease
HCC49_RS08145	COG2176	DNA-directed DNA polymerase activity
HCC49_RS08155	COG0195	Participates in both transcription termination and antitermination
HCC49_RS08160	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HCC49_RS08165	COG1358	cellular component organization or biogenesis
HCC49_RS08175	COG1550	Protein conserved in bacteria
HCC49_RS08190	COG0196	riboflavin kinase activity
HCC49_RS08205	COG0726	polysaccharide deacetylase
HCC49_RS08210	COG0612	Peptidase, M16
HCC49_RS08215	COG1873	PFAM PRC-barrel domain
HCC49_RS08220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCC49_RS08225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCC49_RS08230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCC49_RS08235	COG0527	aspartate kinase activity
HCC49_RS08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCC49_RS08250	COG0740	serine-type endopeptidase activity
HCC49_RS08260	COG4980	gas vesicle protein
HCC49_RS08260	COG1674	ftsk spoiiie
HCC49_RS08265	COG2188	Transcriptional regulator
HCC49_RS08270	COG2814	Major facilitator Superfamily
HCC49_RS08275	COG1846	Transcriptional regulator
HCC49_RS08280	COG2409	Drug exporters of the RND superfamily
HCC49_RS08280	COG1033	growth of symbiont in host cell
HCC49_RS08285	COG0612	Peptidase, M16
HCC49_RS08290	COG0612	Peptidase, M16
HCC49_RS08295	COG0300	oxidoreductase activity
HCC49_RS08310	COG1426	Protein conserved in bacteria
HCC49_RS08315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCC49_RS08330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCC49_RS08340	COG1692	metallophosphoesterase
HCC49_RS08345	COG2359	stage V sporulation protein S
HCC49_RS08365	COG4550	Control of competence regulator ComK, YlbF/YmcA
HCC49_RS08410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS08415	COG3425	synthase
HCC49_RS08420	COG1024	Enoyl-CoA hydratase
HCC49_RS08425	COG1024	Enoyl-CoA hydratase
HCC49_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS08430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08430	COG3321	synthase
HCC49_RS08430	COG0300	oxidoreductase activity
HCC49_RS08435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS08435	COG0300	oxidoreductase activity
HCC49_RS08435	COG3321	synthase
HCC49_RS08435	COG4221	oxidoreductase activity
HCC49_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS08440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS08440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS08440	COG3321	synthase
HCC49_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS08440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS08440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS08440	COG3321	synthase
HCC49_RS08445	COG3321	synthase
HCC49_RS08445	COG4221	oxidoreductase activity
HCC49_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS08450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS08450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCC49_RS08450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCC49_RS08450	COG3321	synthase
HCC49_RS08455	COG2124	cytochrome p450
HCC49_RS08460	COG3209	COG3209 Rhs family protein
HCC49_RS08465	COG3619	membrane
HCC49_RS08475	COG1404	Belongs to the peptidase S8 family
HCC49_RS08485	COG4195	phage-related replication protein
HCC49_RS08490	COG1764	response to oxidative stress
HCC49_RS08500	COG2076	Multidrug Resistance protein
HCC49_RS08540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCC49_RS08545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCC49_RS08550	COG4112	unkown
HCC49_RS08555	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS08565	COG0464	growth
HCC49_RS08570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCC49_RS08575	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCC49_RS08580	COG0789	Transcriptional regulator
HCC49_RS08585	COG0174	glutamine synthetase
HCC49_RS08595	COG2211	Major facilitator Superfamily
HCC49_RS08600	COG3507	Belongs to the glycosyl hydrolase 43 family
HCC49_RS08615	COG1070	Carbohydrate kinase
HCC49_RS08620	COG3848	Pyruvate phosphate dikinase
HCC49_RS08620	COG0574	Belongs to the PEP-utilizing enzyme family
HCC49_RS08635	COG1064	alcohol dehydrogenase
HCC49_RS08660	COG0456	acetyltransferase
HCC49_RS08680	COG3397	chitin binding
HCC49_RS08700	COG5434	Belongs to the glycosyl hydrolase 28 family
HCC49_RS08705	COG0756	dUTP diphosphatase activity
HCC49_RS08710	COG4195	phage-related replication protein
HCC49_RS08745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCC49_RS08755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCC49_RS08775	COG0785	Cytochrome C biogenesis protein
HCC49_RS08780	COG2201	protein-glutamate methylesterase activity
HCC49_RS08785	COG4846	Membrane protein involved in cytochrome C biogenesis
HCC49_RS08795	COG0071	Belongs to the small heat shock protein (HSP20) family
HCC49_RS08810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCC49_RS08815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS08835	COG0824	Thioesterase
HCC49_RS08845	COG4841	protein insertion into membrane
HCC49_RS08855	COG1832	CoA-binding protein
HCC49_RS08860	COG0187	DNA topoisomerase II activity
HCC49_RS08865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCC49_RS08875	COG1115	amino acid carrier protein
HCC49_RS08885	COG1063	alcohol dehydrogenase
HCC49_RS08890	COG0800	Aldolase
HCC49_RS08895	COG1312	Catalyzes the dehydration of D-mannonate
HCC49_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08905	COG1609	Transcriptional regulator
HCC49_RS08910	COG2271	Major facilitator Superfamily
HCC49_RS08950	COG2205	protein histidine kinase activity
HCC49_RS08955	COG0745	RESPONSE REGULATOR receiver
HCC49_RS08965	COG3507	Belongs to the glycosyl hydrolase 43 family
HCC49_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS08995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCC49_RS09000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCC49_RS09005	COG2610	gluconate transmembrane transporter activity
HCC49_RS09010	COG2124	cytochrome p450
HCC49_RS09030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCC49_RS09040	COG2246	polysaccharide biosynthetic process
HCC49_RS09045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCC49_RS09050	COG0586	Pfam SNARE associated Golgi protein
HCC49_RS09055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCC49_RS09060	COG1024	Enoyl-CoA hydratase
HCC49_RS09065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCC49_RS09070	COG0511	ligase activity, forming carbon-carbon bonds
HCC49_RS09075	COG0439	Biotin carboxylase
HCC49_RS09080	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS09085	COG1960	acyl-CoA dehydrogenase activity
HCC49_RS09090	COG1649	PFAM Uncharacterised BCR, COG1649
HCC49_RS09100	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCC49_RS09100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS09105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS09110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS09125	COG2027	D-alanyl-D-alanine carboxypeptidase
HCC49_RS09130	COG2017	converts alpha-aldose to the beta-anomer
HCC49_RS09135	COG0534	Mate efflux family protein
HCC49_RS09150	COG0582	viral genome integration into host DNA
HCC49_RS09155	COG0166	Belongs to the GPI family
HCC49_RS09160	COG0405	Gamma-glutamyltransferase
HCC49_RS09165	COG2814	Major facilitator Superfamily
HCC49_RS09170	COG0640	Transcriptional regulator
HCC49_RS09185	COG0604	alcohol dehydrogenase
HCC49_RS09195	COG0493	'glutamate synthase
HCC49_RS09200	COG0067	glutamate synthase
HCC49_RS09200	COG0069	glutamate synthase activity
HCC49_RS09200	COG0070	glutamate synthase
HCC49_RS09205	COG0583	DNA-binding transcription factor activity
HCC49_RS09210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCC49_RS09225	COG0300	oxidoreductase activity
HCC49_RS09230	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCC49_RS09240	COG2814	Major facilitator Superfamily
HCC49_RS09245	COG1070	Carbohydrate kinase
HCC49_RS09250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCC49_RS09255	COG0243	molybdopterin cofactor binding
HCC49_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS09280	COG1733	regulation of RNA biosynthetic process
HCC49_RS09285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCC49_RS09290	COG2207	Transcriptional regulator
HCC49_RS09290	COG0662	Cupin 2, conserved barrel domain protein
HCC49_RS09295	COG1309	transcriptional regulator
HCC49_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS09310	COG0640	Transcriptional regulator
HCC49_RS09315	COG0741	lytic transglycosylase activity
HCC49_RS09320	COG2322	membrane
HCC49_RS09335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCC49_RS09345	COG3584	3D domain protein
HCC49_RS09345	COG1388	LysM domain
HCC49_RS09350	COG0514	ATP-dependent DNA helicase (RecQ)
HCC49_RS09360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCC49_RS09365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCC49_RS09380	COG0071	Belongs to the small heat shock protein (HSP20) family
HCC49_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS09415	COG1657	PFAM Prenyltransferase squalene oxidase
HCC49_RS09420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCC49_RS09425	COG0733	neurotransmitter:sodium symporter activity
HCC49_RS09430	COG0385	Bile acid
HCC49_RS09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS09440	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCC49_RS09450	COG4548	von Willebrand factor, type A
HCC49_RS09455	COG0714	Associated with various cellular activities
HCC49_RS09460	COG2032	superoxide dismutase activity
HCC49_RS09465	COG1388	LysM domain
HCC49_RS09465	COG0791	NLP P60 protein
HCC49_RS09470	COG1819	glycosyl
HCC49_RS09475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCC49_RS09480	COG0534	Mate efflux family protein
HCC49_RS09485	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS09490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCC49_RS09495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCC49_RS09505	COG2962	Rard protein
HCC49_RS09520	COG1942	4-Oxalocrotonate Tautomerase
HCC49_RS09530	COG1733	regulation of RNA biosynthetic process
HCC49_RS09535	COG0778	Nitroreductase
HCC49_RS09540	COG0400	carboxylic ester hydrolase activity
HCC49_RS09545	COG0346	lactoylglutathione lyase activity
HCC49_RS09555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCC49_RS09565	COG2723	6-phospho-beta-galactosidase activity
HCC49_RS09570	COG2188	Transcriptional regulator
HCC49_RS09575	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS09575	COG0793	Belongs to the peptidase S41A family
HCC49_RS09580	COG2226	methyltransferase
HCC49_RS09590	COG1876	peptidase activity
HCC49_RS09610	COG0671	phosphoesterase, PA-phosphatase related
HCC49_RS09645	COG1509	lysine 2,3-aminomutase activity
HCC49_RS09650	COG0456	acetyltransferase
HCC49_RS09655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCC49_RS09660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCC49_RS09665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCC49_RS09670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCC49_RS09675	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HCC49_RS09685	COG0456	acetyltransferase
HCC49_RS09690	COG0463	Glycosyl transferase, family 2
HCC49_RS09705	COG4641	Protein conserved in bacteria
HCC49_RS09715	COG1086	Polysaccharide biosynthesis protein
HCC49_RS09745	COG1388	LysM domain
HCC49_RS09750	COG0457	Tetratricopeptide repeat
HCC49_RS09780	COG5444	nuclease activity
HCC49_RS09785	COG4282	regulation of fungal-type cell wall biogenesis
HCC49_RS09790	COG1525	nuclease
HCC49_RS09805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCC49_RS09825	COG1846	Transcriptional regulator
HCC49_RS09830	COG4698	Protein conserved in bacteria
HCC49_RS09835	COG2755	lipolytic protein G-D-S-L family
HCC49_RS09840	COG1999	signal sequence binding
HCC49_RS09850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCC49_RS09855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCC49_RS09860	COG1272	protein, Hemolysin III
HCC49_RS09865	COG0204	Acyl-transferase
HCC49_RS09870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCC49_RS09885	COG2521	methyltransferase
HCC49_RS09885	COG2136	Putative SAM-dependent methyltransferase
HCC49_RS09900	COG1413	lyase activity
HCC49_RS09905	COG1418	mRNA catabolic process
HCC49_RS09910	COG0386	Belongs to the glutathione peroxidase family
HCC49_RS09920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCC49_RS09930	COG1278	Cold shock
HCC49_RS09950	COG0328	RNA-DNA hybrid ribonuclease activity
HCC49_RS09955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCC49_RS09960	COG0328	RNA-DNA hybrid ribonuclease activity
HCC49_RS09970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCC49_RS09985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCC49_RS09995	COG1755	Isoprenylcysteine carboxyl methyltransferase
HCC49_RS10000	COG3424	synthase
HCC49_RS10025	COG1335	isochorismatase
HCC49_RS10035	COG2233	PERMEase
HCC49_RS10045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCC49_RS10050	COG1199	ATP-dependent helicase activity
HCC49_RS10065	COG0116	Belongs to the methyltransferase superfamily
HCC49_RS10095	COG3359	exonuclease
HCC49_RS10100	COG1111	helicase
HCC49_RS10100	COG1205	dead DEAH box helicase
HCC49_RS10105	COG2190	(PTS) system
HCC49_RS10110	COG0071	Belongs to the small heat shock protein (HSP20) family
HCC49_RS10150	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCC49_RS10150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCC49_RS10160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCC49_RS10165	COG3935	DnaD domain protein
HCC49_RS10175	COG0436	Aminotransferase
HCC49_RS10180	COG5353	protein conserved in bacteria
HCC49_RS10190	COG1199	ATP-dependent helicase activity
HCC49_RS10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCC49_RS10220	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS10225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCC49_RS10240	COG1694	Mazg nucleotide pyrophosphohydrolase
HCC49_RS10245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS10250	COG2140	Oxalate decarboxylase
HCC49_RS10260	COG4347	Protein of unknown function (DUF1405)
HCC49_RS10265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCC49_RS10265	COG2010	Cytochrome c
HCC49_RS10270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCC49_RS10275	COG0723	plastoquinol--plastocyanin reductase activity
HCC49_RS10290	COG0457	Tetratricopeptide repeat
HCC49_RS10300	COG0287	Prephenate dehydrogenase
HCC49_RS10335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCC49_RS10340	COG4401	Chorismate mutase type I
HCC49_RS10355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCC49_RS10360	COG0105	UTP biosynthetic process
HCC49_RS10365	COG0142	geranyltranstransferase activity
HCC49_RS10375	COG0142	geranyltranstransferase activity
HCC49_RS10390	COG0776	regulation of translation
HCC49_RS10395	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCC49_RS10435	COG0539	negative regulation of cytoplasmic translation
HCC49_RS10450	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HCC49_RS10455	COG2959	enzyme of heme biosynthesis
HCC49_RS10460	COG3773	Cell wall hydrolase
HCC49_RS10460	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS10465	COG2339	peptidase activity
HCC49_RS10470	COG0492	ferredoxin-NADP+ reductase activity
HCC49_RS10475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCC49_RS10480	COG4862	establishment of competence for transformation
HCC49_RS10485	COG1408	metallophosphoesterase
HCC49_RS10495	COG1388	LysM domain
HCC49_RS10500	COG1266	CAAX protease self-immunity
HCC49_RS10505	COG0514	ATP-dependent DNA helicase (RecQ)
HCC49_RS10510	COG4955	Helix-turn-helix domain
HCC49_RS10515	COG1141	Ferredoxin
HCC49_RS10520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HCC49_RS10525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCC49_RS10535	COG1595	DNA-templated transcription, initiation
HCC49_RS10540	COG5002	protein histidine kinase activity
HCC49_RS10545	COG0745	RESPONSE REGULATOR receiver
HCC49_RS10550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCC49_RS10555	COG1333	cytochrome c biogenesis protein
HCC49_RS10560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS10565	COG1187	pseudouridine synthase activity
HCC49_RS10570	COG0700	Nucleoside recognition
HCC49_RS10575	COG2715	membrane protein required for spore maturation
HCC49_RS10580	COG1686	Belongs to the peptidase S11 family
HCC49_RS10605	COG1547	Domain of unknown function (DUF309)
HCC49_RS10610	COG0456	acetyltransferase
HCC49_RS10625	COG0307	riboflavin synthase, alpha
HCC49_RS10630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCC49_RS10630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCC49_RS10640	COG0681	Belongs to the peptidase S26 family
HCC49_RS10650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCC49_RS10655	COG4086	secreted protein
HCC49_RS10660	COG0019	diaminopimelate decarboxylase activity
HCC49_RS10665	COG0697	spore germination
HCC49_RS10680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCC49_RS10700	COG1191	sigma factor activity
HCC49_RS10710	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS10715	COG1686	Belongs to the peptidase S11 family
HCC49_RS10720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCC49_RS10725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HCC49_RS10730	COG4974	Belongs to the 'phage' integrase family
HCC49_RS10740	COG0735	belongs to the Fur family
HCC49_RS10745	COG1300	Membrane
HCC49_RS10760	COG0281	malic enzyme
HCC49_RS10765	COG1757	Na H antiporter
HCC49_RS10770	COG1027	Aspartate ammonia-lyase
HCC49_RS10775	COG0252	asparaginase activity
HCC49_RS10780	COG1396	sequence-specific DNA binding
HCC49_RS10785	COG1379	DNA repair
HCC49_RS10790	COG0494	nUDIX hydrolase
HCC49_RS10800	COG0667	Aldo Keto reductase
HCC49_RS10810	COG1073	alpha beta
HCC49_RS10820	COG4918	Iron-sulphur cluster biosynthesis
HCC49_RS10825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCC49_RS10825	COG0456	acetyltransferase
HCC49_RS10830	COG2329	Antibiotic biosynthesis monooxygenase
HCC49_RS10835	COG0456	acetyltransferase
HCC49_RS10840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCC49_RS10855	COG0628	permease
HCC49_RS10865	COG0346	lactoylglutathione lyase activity
HCC49_RS10875	COG3048	D-serine ammonia-lyase activity
HCC49_RS10880	COG0300	oxidoreductase activity
HCC49_RS10885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS10890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCC49_RS10895	COG1024	Enoyl-CoA hydratase
HCC49_RS10900	COG3425	synthase
HCC49_RS10905	COG2124	cytochrome p450
HCC49_RS10910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS10910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS10910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10910	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10910	COG3321	synthase
HCC49_RS10915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS10915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS10915	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10915	COG3321	synthase
HCC49_RS10920	COG3321	synthase
HCC49_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10920	COG0300	oxidoreductase activity
HCC49_RS10920	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10925	COG3321	synthase
HCC49_RS10925	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS10925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10925	COG0300	oxidoreductase activity
HCC49_RS10930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS10930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS10930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10930	COG3321	synthase
HCC49_RS10935	COG0300	oxidoreductase activity
HCC49_RS10935	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS10935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10935	COG3321	synthase
HCC49_RS10940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS10940	COG3321	synthase
HCC49_RS10940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCC49_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS10950	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS10965	COG2070	2-Nitropropane dioxygenase
HCC49_RS10965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCC49_RS10970	COG0250	Participates in transcription elongation, termination and antitermination
HCC49_RS10990	COG0596	Alpha beta hydrolase
HCC49_RS11005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCC49_RS11010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCC49_RS11025	COG0706	membrane insertase activity
HCC49_RS11030	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCC49_RS11035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCC49_RS11040	COG0346	lactoylglutathione lyase activity
HCC49_RS11050	COG1376	ErfK ybiS ycfS ynhG family protein
HCC49_RS11055	COG4129	membrane
HCC49_RS11060	COG1126	abc transporter atp-binding protein
HCC49_RS11065	COG0765	amino acid transport
HCC49_RS11070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS11080	COG1597	lipid kinase activity
HCC49_RS11085	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCC49_RS11090	COG0022	dehydrogenase e1 component
HCC49_RS11095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCC49_RS11100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCC49_RS11105	COG3426	butyrate kinase activity
HCC49_RS11110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCC49_RS11115	COG0280	phosphate acetyltransferase
HCC49_RS11120	COG3829	transcription factor binding
HCC49_RS11120	COG3290	protein histidine kinase activity
HCC49_RS11130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCC49_RS11135	COG2079	MmgE PrpD family protein
HCC49_RS11140	COG0372	Belongs to the citrate synthase family
HCC49_RS11145	COG1960	acyl-CoA dehydrogenase activity
HCC49_RS11150	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCC49_RS11155	COG0183	Belongs to the thiolase family
HCC49_RS11160	COG0584	glycerophosphoryl diester phosphodiesterase
HCC49_RS11165	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS11190	COG1902	pentaerythritol trinitrate reductase activity
HCC49_RS11205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCC49_RS11210	COG0745	RESPONSE REGULATOR receiver
HCC49_RS11215	COG0750	zinc metalloprotease
HCC49_RS11220	COG0497	DNA recombination
HCC49_RS11230	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCC49_RS11240	COG0142	geranyltranstransferase activity
HCC49_RS11250	COG1570	exodeoxyribonuclease VII activity
HCC49_RS11265	COG1302	Protein conserved in bacteria
HCC49_RS11270	COG0439	Biotin carboxylase
HCC49_RS11275	COG0511	ligase activity, forming carbon-carbon bonds
HCC49_RS11315	COG3854	ATPases associated with a variety of cellular activities
HCC49_RS11330	COG0006	proline dipeptidase activity
HCC49_RS11340	COG3872	metal-dependent enzyme
HCC49_RS11350	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCC49_RS11365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCC49_RS11385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCC49_RS11400	COG1396	sequence-specific DNA binding
HCC49_RS11410	COG0681	Belongs to the peptidase S26 family
HCC49_RS11435	COG4940	Competence protein ComGF
HCC49_RS11445	COG4970	Tfp pilus assembly protein FimT
HCC49_RS11450	COG4537	Required for transformation and DNA binding
HCC49_RS11455	COG1459	type II secretion system
HCC49_RS11460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCC49_RS11465	COG0598	Magnesium transport protein CorA
HCC49_RS11470	COG1253	flavin adenine dinucleotide binding
HCC49_RS11475	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS11485	COG1393	Belongs to the ArsC family
HCC49_RS11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS11505	COG0011	TIGRFAM Protein of
HCC49_RS11515	COG2866	Carboxypeptidase
HCC49_RS11520	COG1940	carbohydrate kinase activity
HCC49_RS11525	COG4483	Protein conserved in bacteria
HCC49_RS11530	COG1757	Na H antiporter
HCC49_RS11540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCC49_RS11555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCC49_RS11560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCC49_RS11565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCC49_RS11570	COG0581	inorganic phosphate transmembrane transporter activity
HCC49_RS11575	COG0573	inorganic phosphate transmembrane transporter activity
HCC49_RS11580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCC49_RS11590	COG0477	Major facilitator Superfamily
HCC49_RS11595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCC49_RS11600	COG2839	Protein conserved in bacteria
HCC49_RS11605	COG5521	maltodextrose utilization protein MalA
HCC49_RS11610	COG1388	LysM domain
HCC49_RS11620	COG4709	membrane
HCC49_RS11625	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HCC49_RS11630	COG0735	belongs to the Fur family
HCC49_RS11635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS11650	COG0513	Belongs to the DEAD box helicase family
HCC49_RS11665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCC49_RS11670	COG2384	SAM-dependent methyltransferase
HCC49_RS11675	COG2010	Cytochrome c
HCC49_RS11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCC49_RS11685	COG0358	DNA primase activity
HCC49_RS11700	COG0517	IMP dehydrogenase activity
HCC49_RS11705	COG0751	glycine-tRNA ligase activity
HCC49_RS11725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCC49_RS11730	COG0295	cytidine deaminase activity
HCC49_RS11735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCC49_RS11745	COG1480	7TM receptor with intracellular HD hydrolase
HCC49_RS11750	COG1702	phosphate starvation-inducible protein PhoH
HCC49_RS11755	COG0561	phosphatase activity
HCC49_RS11770	COG4864	UPF0365 protein
HCC49_RS11775	COG1030	water channel activity
HCC49_RS11780	COG1610	YqeY-like protein
HCC49_RS11790	COG1283	sodium-dependent phosphate transmembrane transporter activity
HCC49_RS11795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCC49_RS11800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCC49_RS11830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCC49_RS11845	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS11860	COG1466	dna polymerase III delta subunit
HCC49_RS11875	COG2333	competence protein COMEC
HCC49_RS11875	COG0658	competence protein
HCC49_RS11880	COG2131	deaminase
HCC49_RS11885	COG1555	photosystem II stabilization
HCC49_RS11885	COG1596	polysaccharide export
HCC49_RS11890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCC49_RS11895	COG2226	methyltransferase
HCC49_RS11900	COG0799	negative regulation of ribosome biogenesis
HCC49_RS11905	COG1713	HD superfamily hydrolase involved in NAD metabolism
HCC49_RS11915	COG1534	Rna-binding protein
HCC49_RS11920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCC49_RS11925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCC49_RS11930	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCC49_RS11940	COG2755	lipolytic protein G-D-S-L family
HCC49_RS11950	COG0398	Pfam SNARE associated Golgi protein
HCC49_RS12000	COG0512	Glutamine amidotransferase of anthranilate synthase
HCC49_RS12025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCC49_RS12040	COG2378	regulation of single-species biofilm formation
HCC49_RS12045	COG0693	protein deglycase activity
HCC49_RS12085	COG1794	racemase activity, acting on amino acids and derivatives
HCC49_RS12095	COG1733	regulation of RNA biosynthetic process
HCC49_RS12100	COG0656	L-ascorbic acid biosynthetic process
HCC49_RS12135	COG0563	adenylate kinase activity
HCC49_RS12145	COG2814	Major facilitator Superfamily
HCC49_RS12155	COG0456	acetyltransferase
HCC49_RS12160	COG2318	DinB family
HCC49_RS12170	COG0561	phosphatase activity
HCC49_RS12175	COG0561	phosphatase activity
HCC49_RS12185	COG1482	cell wall glycoprotein biosynthetic process
HCC49_RS12190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS12190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCC49_RS12190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCC49_RS12195	COG3711	transcriptional antiterminator
HCC49_RS12195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS12205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCC49_RS12210	COG0583	DNA-binding transcription factor activity
HCC49_RS12215	COG2814	Major facilitator Superfamily
HCC49_RS12220	COG2124	cytochrome p450
HCC49_RS12220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCC49_RS12225	COG1309	transcriptional regulator
HCC49_RS12230	COG2226	methyltransferase
HCC49_RS12245	COG2116	formate transmembrane transporter activity
HCC49_RS12250	COG5609	conserved protein (DUF2294)
HCC49_RS12255	COG3383	formate dehydrogenase (NAD+) activity
HCC49_RS12260	COG2427	Protein of unknown function (DUF1641)
HCC49_RS12270	COG0626	cystathionine gamma-synthase activity
HCC49_RS12275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCC49_RS12300	COG0768	penicillin binding
HCC49_RS12325	COG4122	O-methyltransferase activity
HCC49_RS12330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCC49_RS12345	COG4472	Bacterial protein of unknown function (DUF965)
HCC49_RS12355	COG0628	permease
HCC49_RS12360	COG1126	abc transporter atp-binding protein
HCC49_RS12365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS12370	COG0765	amino acid transport
HCC49_RS12375	COG0765	amino acid transport
HCC49_RS12390	COG3881	PFAM PRC-barrel domain
HCC49_RS12395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCC49_RS12400	COG0457	Tetratricopeptide repeat
HCC49_RS12410	COG1104	cysteine desulfurase activity
HCC49_RS12415	COG1959	2 iron, 2 sulfur cluster binding
HCC49_RS12420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCC49_RS12425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCC49_RS12450	COG3103	Sh3 type 3 domain protein
HCC49_RS12450	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS12450	COG4991	sh3 domain protein
HCC49_RS12460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCC49_RS12470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCC49_RS12470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCC49_RS12475	COG5416	Lipopolysaccharide assembly protein A domain
HCC49_RS12480	COG0490	domain, Protein
HCC49_RS12485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCC49_RS12485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCC49_RS12495	COG2244	polysaccharide biosynthetic process
HCC49_RS12500	COG2323	membrane
HCC49_RS12510	COG1862	Preprotein translocase
HCC49_RS12550	COG1388	LysM domain
HCC49_RS12560	COG0157	Belongs to the NadC ModD family
HCC49_RS12565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCC49_RS12570	COG1104	cysteine desulfurase activity
HCC49_RS12575	COG1827	regulation of RNA biosynthetic process
HCC49_RS12580	COG0077	Prephenate dehydratase
HCC49_RS12595	COG3290	protein histidine kinase activity
HCC49_RS12600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCC49_RS12605	COG2868	ribosomal protein
HCC49_RS12615	COG1994	Peptidase M50
HCC49_RS12620	COG0739	heme binding
HCC49_RS12625	COG2894	cell division
HCC49_RS12635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCC49_RS12645	COG1077	Cell shape determining protein MreB Mrl
HCC49_RS12665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCC49_RS12670	COG0285	dihydrofolate synthase activity
HCC49_RS12675	COG0525	valine-tRNA ligase activity
HCC49_RS12685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCC49_RS12690	COG1388	LysM domain
HCC49_RS12700	COG0113	porphobilinogen synthase activity
HCC49_RS12705	COG1587	Uroporphyrinogen-III synthase
HCC49_RS12715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCC49_RS12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCC49_RS12740	COG1067	ATP-dependent peptidase activity
HCC49_RS12740	COG0470	DNA polymerase III
HCC49_RS12755	COG1477	protein flavinylation
HCC49_RS12755	COG0457	Tetratricopeptide repeat
HCC49_RS12770	COG0473	3-isopropylmalate dehydrogenase activity
HCC49_RS12785	COG0440	acetolactate synthase activity
HCC49_RS12790	COG0028	Belongs to the TPP enzyme family
HCC49_RS12815	COG0622	Phosphoesterase
HCC49_RS12820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCC49_RS12830	COG5401	PFAM Sporulation and spore germination
HCC49_RS12840	COG1846	Transcriptional regulator
HCC49_RS12845	COG2197	response regulator
HCC49_RS12850	COG0824	Thioesterase
HCC49_RS12855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCC49_RS12860	COG1053	succinate dehydrogenase
HCC49_RS12865	COG2009	succinate dehydrogenase
HCC49_RS12870	COG1719	4-vinyl reductase, 4VR
HCC49_RS12875	COG0527	aspartate kinase activity
HCC49_RS12885	COG3118	belongs to the thioredoxin family
HCC49_RS12890	COG3534	alpha-L-arabinofuranosidase
HCC49_RS12895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCC49_RS12900	COG2086	electron transfer activity
HCC49_RS12905	COG1024	Enoyl-CoA hydratase
HCC49_RS12910	COG1309	transcriptional regulator
HCC49_RS12915	COG0318	PFAM AMP-dependent synthetase and ligase
HCC49_RS12925	COG3766	membrane
HCC49_RS12935	COG1796	DNA polymerase
HCC49_RS12935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCC49_RS12940	COG1286	toxin biosynthetic process
HCC49_RS12955	COG0072	phenylalanine-tRNA ligase activity
HCC49_RS12955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCC49_RS12960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCC49_RS12965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCC49_RS12975	COG3835	regulator
HCC49_RS12980	COG0277	FAD linked oxidase domain protein
HCC49_RS12985	COG0247	lactate metabolic process
HCC49_RS12990	COG1966	Carbon starvation protein
HCC49_RS12995	COG3534	alpha-L-arabinofuranosidase
HCC49_RS13000	COG0395	ABC-type sugar transport system, permease component
HCC49_RS13005	COG1175	transmembrane transport
HCC49_RS13010	COG1653	transport
HCC49_RS13020	COG0647	UMP catabolic process
HCC49_RS13025	COG0235	Class ii aldolase
HCC49_RS13030	COG1069	ribulokinase activity
HCC49_RS13035	COG2160	L-arabinose isomerase activity
HCC49_RS13040	COG3507	Belongs to the glycosyl hydrolase 43 family
HCC49_RS13045	COG1363	Peptidase, m42
HCC49_RS13055	COG3326	Membrane
HCC49_RS13060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCC49_RS13070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCC49_RS13075	COG1346	cytolysis
HCC49_RS13080	COG1380	Effector of murein hydrolase LrgA
HCC49_RS13085	COG3279	Response regulator of the LytR AlgR family
HCC49_RS13090	COG3275	phosphorelay sensor kinase activity
HCC49_RS13095	COG1011	Hydrolase
HCC49_RS13110	COG0398	Pfam SNARE associated Golgi protein
HCC49_RS13115	COG1484	DNA-dependent DNA replication
HCC49_RS13120	COG3611	Membrane attachment protein
HCC49_RS13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCC49_RS13140	COG1733	regulation of RNA biosynthetic process
HCC49_RS13145	COG2814	Major facilitator Superfamily
HCC49_RS13150	COG0656	L-ascorbic acid biosynthetic process
HCC49_RS13155	COG0237	dephospho-CoA kinase activity
HCC49_RS13160	COG1971	Probably functions as a manganese efflux pump
HCC49_RS13165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCC49_RS13170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCC49_RS13170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCC49_RS13175	COG5002	protein histidine kinase activity
HCC49_RS13180	COG0745	RESPONSE REGULATOR receiver
HCC49_RS13190	COG0538	isocitrate dehydrogenase activity
HCC49_RS13195	COG0372	Belongs to the citrate synthase family
HCC49_RS13205	COG0457	Tetratricopeptide repeat
HCC49_RS13235	COG0628	permease
HCC49_RS13240	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCC49_RS13245	COG0469	pyruvate kinase activity
HCC49_RS13265	COG0281	malic enzyme
HCC49_RS13270	COG0587	DNA-directed DNA polymerase activity
HCC49_RS13290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCC49_RS13300	COG4109	DRTGG domain
HCC49_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS13325	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCC49_RS13335	COG0827	DNA restriction-modification system
HCC49_RS13340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCC49_RS13345	COG3874	Sporulation protein YtfJ
HCC49_RS13355	COG1714	RDD family
HCC49_RS13360	COG0616	signal peptide processing
HCC49_RS13365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCC49_RS13370	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCC49_RS13375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCC49_RS13390	COG1104	cysteine desulfurase activity
HCC49_RS13395	COG1114	Component of the transport system for branched-chain amino acids
HCC49_RS13405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCC49_RS13410	COG1309	transcriptional regulator
HCC49_RS13415	COG1956	GAF domain-containing protein
HCC49_RS13420	COG2203	Gaf domain
HCC49_RS13420	COG2199	diguanylate cyclase activity
HCC49_RS13435	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS13440	COG4282	regulation of fungal-type cell wall biogenesis
HCC49_RS13445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCC49_RS13445	COG1017	nitric oxide dioxygenase activity
HCC49_RS13455	COG0693	protein deglycase activity
HCC49_RS13470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCC49_RS13475	COG1378	Sugar-specific transcriptional regulator TrmB
HCC49_RS13495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCC49_RS13500	COG0454	-acetyltransferase
HCC49_RS13505	COG0517	IMP dehydrogenase activity
HCC49_RS13510	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCC49_RS13515	COG1360	Flagellar Motor Protein
HCC49_RS13520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCC49_RS13525	COG1609	Transcriptional regulator
HCC49_RS13530	COG1605	Chorismate mutase
HCC49_RS13530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCC49_RS13535	COG3118	belongs to the thioredoxin family
HCC49_RS13540	COG4980	gas vesicle protein
HCC49_RS13545	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCC49_RS13555	COG1674	ftsk spoiiie
HCC49_RS13560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCC49_RS13570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS13580	COG1363	Peptidase, m42
HCC49_RS13585	COG5584	Small secreted protein
HCC49_RS13590	COG0281	malic enzyme
HCC49_RS13595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCC49_RS13610	COG0510	thiamine kinase activity
HCC49_RS13615	COG1597	lipid kinase activity
HCC49_RS13625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCC49_RS13630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCC49_RS13635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCC49_RS13640	COG2252	PERMEase
HCC49_RS13645	COG4473	ABC transporter
HCC49_RS13650	COG1131	(ABC) transporter
HCC49_RS13655	COG1349	DNA-binding transcription factor activity
HCC49_RS13660	COG1187	pseudouridine synthase activity
HCC49_RS13665	COG2244	polysaccharide biosynthetic process
HCC49_RS13670	COG2081	HI0933 family
HCC49_RS13675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCC49_RS13685	COG1609	Transcriptional regulator
HCC49_RS13690	COG1653	transport
HCC49_RS13695	COG1175	transmembrane transport
HCC49_RS13700	COG0395	ABC-type sugar transport system, permease component
HCC49_RS13705	COG1486	melibiose metabolic process
HCC49_RS13715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCC49_RS13730	COG1366	Belongs to the anti-sigma-factor antagonist family
HCC49_RS13730	COG2202	Pas domain
HCC49_RS13735	COG2814	Major facilitator Superfamily
HCC49_RS13740	COG5522	Integral membrane protein (intg_mem_TP0381)
HCC49_RS13745	COG0577	efflux transmembrane transporter activity
HCC49_RS13750	COG1136	(ABC) transporter
HCC49_RS13755	COG2205	protein histidine kinase activity
HCC49_RS13760	COG0745	RESPONSE REGULATOR receiver
HCC49_RS13765	COG0577	efflux transmembrane transporter activity
HCC49_RS13770	COG1136	(ABC) transporter
HCC49_RS13790	COG1131	(ABC) transporter
HCC49_RS13795	COG1725	Transcriptional regulator
HCC49_RS13805	COG0640	Transcriptional regulator
HCC49_RS13810	COG0477	Major facilitator Superfamily
HCC49_RS13815	COG1242	4 iron, 4 sulfur cluster binding
HCC49_RS13820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCC49_RS13830	COG0584	glycerophosphoryl diester phosphodiesterase
HCC49_RS13840	COG2267	carboxylic ester hydrolase activity
HCC49_RS13845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCC49_RS13850	COG1113	amino acid transport
HCC49_RS13855	COG0367	asparagine synthase
HCC49_RS13875	COG1506	peptidase
HCC49_RS13880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCC49_RS13885	COG1116	anion transmembrane transporter activity
HCC49_RS13890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCC49_RS13895	COG0494	nUDIX hydrolase
HCC49_RS13900	COG4824	toxin secretion phage lysis holin
HCC49_RS13905	COG0783	Belongs to the Dps family
HCC49_RS13930	COG0288	reversible hydration of carbon dioxide
HCC49_RS13940	COG1271	oxidase subunit
HCC49_RS13945	COG1294	oxidase, subunit
HCC49_RS13955	COG4948	Mandelate Racemase Muconate Lactonizing
HCC49_RS13965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCC49_RS13970	COG0596	Alpha beta hydrolase
HCC49_RS13980	COG1169	isochorismate synthase
HCC49_RS13985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCC49_RS13990	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HCC49_RS14105	COG3859	Proton-coupled thiamine transporter YuaJ
HCC49_RS14110	COG2268	Band 7 protein
HCC49_RS14115	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCC49_RS14120	COG2318	DinB family
HCC49_RS14130	COG1454	alcohol dehydrogenase
HCC49_RS14135	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS14140	COG1510	regulation of RNA biosynthetic process
HCC49_RS14150	COG0569	domain protein
HCC49_RS14155	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCC49_RS14160	COG1017	nitric oxide dioxygenase activity
HCC49_RS14160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCC49_RS14175	COG0457	Tetratricopeptide repeat
HCC49_RS14200	COG0628	permease
HCC49_RS14205	COG0673	inositol 2-dehydrogenase activity
HCC49_RS14210	COG0693	protein deglycase activity
HCC49_RS14215	COG0840	transmembrane signaling receptor activity
HCC49_RS14220	COG0840	transmembrane signaling receptor activity
HCC49_RS14225	COG0840	transmembrane signaling receptor activity
HCC49_RS14230	COG0840	transmembrane signaling receptor activity
HCC49_RS14245	COG2070	2-Nitropropane dioxygenase
HCC49_RS14250	COG0432	Pfam Uncharacterised protein family UPF0047
HCC49_RS14255	COG0366	Alpha amylase catalytic
HCC49_RS14260	COG1253	flavin adenine dinucleotide binding
HCC49_RS14265	COG2738	Putative neutral zinc metallopeptidase
HCC49_RS14280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCC49_RS14305	COG1335	isochorismatase
HCC49_RS14310	COG1979	alcohol dehydrogenase
HCC49_RS14315	COG1979	alcohol dehydrogenase
HCC49_RS14320	COG2155	Conserved Protein
HCC49_RS14325	COG1098	S1 RNA binding domain
HCC49_RS14330	COG0436	Aminotransferase
HCC49_RS14335	COG1522	sequence-specific DNA binding
HCC49_RS14340	COG2267	carboxylic ester hydrolase activity
HCC49_RS14355	COG2205	protein histidine kinase activity
HCC49_RS14365	COG5018	Exonuclease
HCC49_RS14370	COG2814	Major facilitator Superfamily
HCC49_RS14375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCC49_RS14380	COG3011	Protein conserved in bacteria
HCC49_RS14390	COG3290	protein histidine kinase activity
HCC49_RS14395	COG4565	transcriptional regulatory protein
HCC49_RS14425	COG2111	Na H antiporter
HCC49_RS14425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCC49_RS14430	COG2111	Na H antiporter
HCC49_RS14435	COG1006	Multisubunit Na H antiporter MnhC subunit
HCC49_RS14440	COG0651	ATP synthesis coupled electron transport
HCC49_RS14445	COG1863	multisubunit Na H antiporter MnhE subunit
HCC49_RS14450	COG2212	antiporter activity
HCC49_RS14455	COG1320	monovalent cation:proton antiporter activity
HCC49_RS14460	COG2050	protein possibly involved in aromatic compounds catabolism
HCC49_RS14465	COG2197	response regulator
HCC49_RS14470	COG4585	Histidine kinase
HCC49_RS14495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HCC49_RS14500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCC49_RS14505	COG1335	isochorismatase
HCC49_RS14510	COG5506	Protein of unknown function (DUF1694)
HCC49_RS14525	COG0628	permease
HCC49_RS14535	COG1418	mRNA catabolic process
HCC49_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS14550	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HCC49_RS14550	COG2508	Transcriptional regulator
HCC49_RS14555	COG0686	Belongs to the AlaDH PNT family
HCC49_RS14560	COG5634	Uncharacterized conserved protein (DUF2278)
HCC49_RS14565	COG3251	PFAM MbtH domain protein
HCC49_RS14570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCC49_RS14575	COG3433	isochorismatase activity
HCC49_RS14575	COG1535	isochorismatase
HCC49_RS14580	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCC49_RS14585	COG1169	isochorismate synthase
HCC49_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS14595	COG2819	hydrolase of the alpha beta superfamily
HCC49_RS14600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCC49_RS14605	COG1268	BioY protein
HCC49_RS14610	COG2056	Na+-H+ antiporter family
HCC49_RS14620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCC49_RS14625	COG3584	3D domain protein
HCC49_RS14640	COG1252	NADH dehydrogenase
HCC49_RS14670	COG1131	(ABC) transporter
HCC49_RS14695	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HCC49_RS14700	COG0316	Belongs to the HesB IscA family
HCC49_RS14710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCC49_RS14720	COG1252	NADH dehydrogenase
HCC49_RS14725	COG4837	Protein of unknown function (DUF1462)
HCC49_RS14730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCC49_RS14735	COG4946	Tricorn protease homolog
HCC49_RS14735	COG1506	peptidase
HCC49_RS14735	COG0823	Involved in the tonB-independent uptake of proteins
HCC49_RS14745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCC49_RS14750	COG0460	homoserine dehydrogenase
HCC49_RS14755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCC49_RS14760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCC49_RS14765	COG0647	UMP catabolic process
HCC49_RS14770	COG2445	Protein of unknown function DUF86
HCC49_RS14775	COG4470	Protein conserved in bacteria
HCC49_RS14785	COG0739	heme binding
HCC49_RS14795	COG0737	Belongs to the 5'-nucleotidase family
HCC49_RS14800	COG0730	response to heat
HCC49_RS14805	COG1801	Protein of unknown function DUF72
HCC49_RS14820	COG2508	Transcriptional regulator
HCC49_RS14835	COG2814	Major facilitator Superfamily
HCC49_RS14840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCC49_RS14845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCC49_RS14850	COG2356	endonuclease I
HCC49_RS14855	COG3842	ATPase activity
HCC49_RS14860	COG2188	Transcriptional regulator
HCC49_RS14865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCC49_RS14870	COG0395	ABC-type sugar transport system, permease component
HCC49_RS14875	COG1175	transmembrane transport
HCC49_RS14880	COG1653	transport
HCC49_RS14885	COG2222	sugar isomerase
HCC49_RS14890	COG0789	Transcriptional regulator
HCC49_RS14915	COG0322	excinuclease ABC activity
HCC49_RS14920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCC49_RS14925	COG2226	methyltransferase
HCC49_RS14935	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS14940	COG0719	Fe-S assembly protein
HCC49_RS14945	COG0822	iron-sulfur transferase activity
HCC49_RS14950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCC49_RS14955	COG0719	Fe-S assembly protein
HCC49_RS14960	COG0396	ATPase activity
HCC49_RS14970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCC49_RS14975	COG1464	Belongs to the NlpA lipoprotein family
HCC49_RS14980	COG2011	ABC-type metal ion transport system permease component
HCC49_RS14985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCC49_RS14995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS15000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCC49_RS15015	COG1393	Belongs to the ArsC family
HCC49_RS15020	COG1960	acyl-CoA dehydrogenase activity
HCC49_RS15025	COG0183	Belongs to the thiolase family
HCC49_RS15030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCC49_RS15030	COG1024	Enoyl-CoA hydratase
HCC49_RS15050	COG5577	PFAM Coat F domain
HCC49_RS15055	COG1846	Transcriptional regulator
HCC49_RS15060	COG0477	Major facilitator Superfamily
HCC49_RS15065	COG0583	DNA-binding transcription factor activity
HCC49_RS15085	COG1120	ATPase activity
HCC49_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS15105	COG0783	Belongs to the Dps family
HCC49_RS15110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCC49_RS15115	COG0745	RESPONSE REGULATOR receiver
HCC49_RS15120	COG2205	protein histidine kinase activity
HCC49_RS15120	COG2770	Histidine kinase
HCC49_RS15130	COG1309	transcriptional regulator
HCC49_RS15135	COG0114	fumarate hydratase activity
HCC49_RS15145	COG0697	spore germination
HCC49_RS15150	COG0814	amino acid
HCC49_RS15160	COG2197	response regulator
HCC49_RS15165	COG4585	Histidine kinase
HCC49_RS15170	COG4758	membrane
HCC49_RS15175	COG3595	metallopeptidase activity
HCC49_RS15180	COG1842	Phage shock protein A
HCC49_RS15185	COG4758	membrane
HCC49_RS15190	COG2814	Major facilitator Superfamily
HCC49_RS15195	COG2096	Adenosyltransferase
HCC49_RS15200	COG1120	ATPase activity
HCC49_RS15205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS15210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCC49_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS15220	COG3386	PFAM SMP-30 Gluconolaconase
HCC49_RS15225	COG2205	protein histidine kinase activity
HCC49_RS15230	COG0745	RESPONSE REGULATOR receiver
HCC49_RS15240	COG1191	sigma factor activity
HCC49_RS15250	COG2140	Oxalate decarboxylase
HCC49_RS15260	COG1120	ATPase activity
HCC49_RS15265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS15270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS15275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCC49_RS15280	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HCC49_RS15285	COG0531	amino acid
HCC49_RS15295	COG1988	membrane-bound metal-dependent
HCC49_RS15300	COG1368	sulfuric ester hydrolase activity
HCC49_RS15305	COG1910	domain protein
HCC49_RS15310	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCC49_RS15315	COG4149	molybdate abc transporter
HCC49_RS15320	COG2197	response regulator
HCC49_RS15325	COG3850	Histidine kinase
HCC49_RS15330	COG1131	(ABC) transporter
HCC49_RS15340	COG0842	Transport permease protein
HCC49_RS15345	COG0656	L-ascorbic acid biosynthetic process
HCC49_RS15365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCC49_RS15370	COG3973	AAA domain
HCC49_RS15375	COG2860	membrane
HCC49_RS15385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HCC49_RS15390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCC49_RS15395	COG2217	Heavy metal translocating P-type atpase
HCC49_RS15400	COG2217	Heavy metal translocating P-type atpase
HCC49_RS15405	COG2608	mercury ion transmembrane transporter activity
HCC49_RS15410	COG1937	Protein conserved in bacteria
HCC49_RS15415	COG0673	inositol 2-dehydrogenase activity
HCC49_RS15425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS15430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCC49_RS15435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS15440	COG1126	abc transporter atp-binding protein
HCC49_RS15445	COG0765	amino acid transport
HCC49_RS15450	COG0765	amino acid transport
HCC49_RS15455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS15460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCC49_RS15465	COG0454	-acetyltransferase
HCC49_RS15470	COG0583	DNA-binding transcription factor activity
HCC49_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS15480	COG2732	(Barnase) inhibitor
HCC49_RS15500	COG0557	exoribonuclease II activity
HCC49_RS15505	COG1647	Serine aminopeptidase, S33
HCC49_RS15510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCC49_RS15515	COG1476	TRANSCRIPTIONal
HCC49_RS15520	COG1396	sequence-specific DNA binding
HCC49_RS15525	COG1396	sequence-specific DNA binding
HCC49_RS15530	COG1733	regulation of RNA biosynthetic process
HCC49_RS15555	COG1131	(ABC) transporter
HCC49_RS15560	COG1174	glycine betaine transport
HCC49_RS15565	COG1732	Glycine betaine
HCC49_RS15570	COG1174	glycine betaine transport
HCC49_RS15575	COG1125	glycine betaine transport
HCC49_RS15575	COG0517	IMP dehydrogenase activity
HCC49_RS15580	COG1510	regulation of RNA biosynthetic process
HCC49_RS15585	COG1174	glycine betaine transport
HCC49_RS15590	COG1732	Glycine betaine
HCC49_RS15595	COG1174	glycine betaine transport
HCC49_RS15600	COG0517	IMP dehydrogenase activity
HCC49_RS15600	COG1125	glycine betaine transport
HCC49_RS15605	COG1510	regulation of RNA biosynthetic process
HCC49_RS15610	COG2095	MarC family integral membrane protein
HCC49_RS15615	COG3064	Membrane
HCC49_RS15620	COG4640	response to antibiotic
HCC49_RS15625	COG0456	acetyltransferase
HCC49_RS15640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCC49_RS15655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCC49_RS15660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCC49_RS15665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCC49_RS15675	COG2234	aminopeptidase activity
HCC49_RS15695	COG0126	phosphoglycerate kinase activity
HCC49_RS15705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCC49_RS15710	COG2390	Transcriptional regulator
HCC49_RS15715	COG2814	Major facilitator Superfamily
HCC49_RS15720	COG1609	Transcriptional regulator
HCC49_RS15730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS15740	COG0583	DNA-binding transcription factor activity
HCC49_RS15745	COG0697	spore germination
HCC49_RS15750	COG1113	amino acid transport
HCC49_RS15760	COG1609	Transcriptional regulator
HCC49_RS15770	COG0561	phosphatase activity
HCC49_RS15775	COG1737	Transcriptional regulator
HCC49_RS15780	COG1070	Carbohydrate kinase
HCC49_RS15805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS15810	COG2186	Transcriptional regulator
HCC49_RS15815	COG1620	l-lactate permease
HCC49_RS15820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCC49_RS15830	COG5039	Polysaccharide pyruvyl transferase
HCC49_RS15835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCC49_RS15840	COG0110	maltose O-acetyltransferase activity
HCC49_RS15845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCC49_RS15850	COG2244	polysaccharide biosynthetic process
HCC49_RS15855	COG1216	Glycosyl transferase, family 2
HCC49_RS15860	COG5039	Polysaccharide pyruvyl transferase
HCC49_RS15865	COG1216	Glycosyl transferase, family 2
HCC49_RS15875	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS15880	COG1215	transferase activity, transferring glycosyl groups
HCC49_RS15885	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS15890	COG1086	Polysaccharide biosynthesis protein
HCC49_RS15895	COG0489	protein tyrosine kinase activity
HCC49_RS15900	COG3944	biosynthesis protein
HCC49_RS15905	COG1396	sequence-specific DNA binding
HCC49_RS15910	COG2272	Belongs to the type-B carboxylesterase lipase family
HCC49_RS15920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCC49_RS15925	COG2364	Membrane
HCC49_RS15930	COG0456	acetyltransferase
HCC49_RS15935	COG3479	Phenolic acid decarboxylase
HCC49_RS15995	COG1357	PFAM Pentapeptide repeats (8 copies)
HCC49_RS16015	COG2223	nitrite transmembrane transporter activity
HCC49_RS16020	COG1609	Transcriptional regulator
HCC49_RS16030	COG0583	DNA-binding transcription factor activity
HCC49_RS16035	COG2828	Protein conserved in bacteria
HCC49_RS16040	COG2814	Major facilitator Superfamily
HCC49_RS16040	COG0477	Major facilitator Superfamily
HCC49_RS16070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS16075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCC49_RS16095	COG0492	ferredoxin-NADP+ reductase activity
HCC49_RS16100	COG3118	belongs to the thioredoxin family
HCC49_RS16110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCC49_RS16120	COG0509	glycine decarboxylation via glycine cleavage system
HCC49_RS16130	COG1309	transcriptional regulator
HCC49_RS16135	COG1609	Transcriptional regulator
HCC49_RS16145	COG1175	transmembrane transport
HCC49_RS16150	COG0395	ABC-type sugar transport system, permease component
HCC49_RS16160	COG1621	beta-fructofuranosidase activity
HCC49_RS16185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCC49_RS16210	COG0210	DNA helicase
HCC49_RS16215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCC49_RS16220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCC49_RS16255	COG1694	Mazg nucleotide pyrophosphohydrolase
HCC49_RS16260	COG0659	secondary active sulfate transmembrane transporter activity
HCC49_RS16265	COG0288	reversible hydration of carbon dioxide
HCC49_RS16275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCC49_RS16280	COG4290	ribonuclease
HCC49_RS16285	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCC49_RS16290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS16300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCC49_RS16310	COG1051	belongs to the nudix hydrolase family
HCC49_RS16315	COG0492	ferredoxin-NADP+ reductase activity
HCC49_RS16320	COG0791	NLP P60 protein
HCC49_RS16320	COG3883	PFAM NLP P60 protein
HCC49_RS16325	COG0457	Tetratricopeptide repeat
HCC49_RS16330	COG5002	protein histidine kinase activity
HCC49_RS16335	COG0745	RESPONSE REGULATOR receiver
HCC49_RS16345	COG1132	(ABC) transporter
HCC49_RS16350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCC49_RS16350	COG0140	phosphoribosyl-ATP diphosphatase activity
HCC49_RS16375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCC49_RS16390	COG4990	cell redox homeostasis
HCC49_RS16395	COG0110	maltose O-acetyltransferase activity
HCC49_RS16415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCC49_RS16425	COG2188	Transcriptional regulator
HCC49_RS16430	COG1309	transcriptional regulator
HCC49_RS16435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCC49_RS16440	COG1950	PFAM Membrane protein of
HCC49_RS16445	COG1983	PspC domain protein
HCC49_RS16450	COG3595	metallopeptidase activity
HCC49_RS16465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCC49_RS16475	COG4897	Protein conserved in bacteria
HCC49_RS16480	COG3848	Pyruvate phosphate dikinase
HCC49_RS16480	COG0574	Belongs to the PEP-utilizing enzyme family
HCC49_RS16485	COG1309	transcriptional regulator
HCC49_RS16490	COG2814	Major facilitator Superfamily
HCC49_RS16505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCC49_RS16515	COG0793	Belongs to the peptidase S41A family
HCC49_RS16515	COG3409	Peptidoglycan-binding domain 1 protein
HCC49_RS16520	COG3420	alginic acid biosynthetic process
HCC49_RS16525	COG2177	Part of the ABC transporter FtsEX involved in
HCC49_RS16530	COG2884	Cell division ATP-binding protein ftsE
HCC49_RS16535	COG2010	Cytochrome c
HCC49_RS16540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS16555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCC49_RS16570	COG1516	flagellar protein fliS
HCC49_RS16575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCC49_RS16580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCC49_RS16600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCC49_RS16605	COG1256	bacterial-type flagellum assembly
HCC49_RS16605	COG4786	Flagellar basal body rod
HCC49_RS16610	COG3418	PFAM FlgN family protein
HCC49_RS16615	COG2747	anti-sigma28 factor FlgM
HCC49_RS16625	COG1040	competence protein
HCC49_RS16635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HCC49_RS16640	COG1307	EDD domain protein, DegV family
HCC49_RS16645	COG2197	response regulator
HCC49_RS16650	COG4585	Histidine kinase
HCC49_RS16655	COG1739	Uncharacterized protein family UPF0029
HCC49_RS16660	COG1316	TRANSCRIPTIONal
HCC49_RS16665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCC49_RS16670	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS16675	COG1215	transferase activity, transferring glycosyl groups
HCC49_RS16680	COG3206	protein involved in exopolysaccharide biosynthesis
HCC49_RS16685	COG3307	-O-antigen
HCC49_RS16690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCC49_RS16695	COG0297	glycogen (starch) synthase activity
HCC49_RS16695	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS16700	COG2244	polysaccharide biosynthetic process
HCC49_RS16710	COG2247	cell wall binding repeat
HCC49_RS16710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCC49_RS16715	COG2247	cell wall binding repeat
HCC49_RS16715	COG2385	sporulation resulting in formation of a cellular spore
HCC49_RS16725	COG1316	TRANSCRIPTIONal
HCC49_RS16730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCC49_RS16735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCC49_RS16740	COG1134	teichoic acid transport
HCC49_RS16745	COG1682	transport, permease protein
HCC49_RS16750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCC49_RS16760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCC49_RS16765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCC49_RS16770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCC49_RS16775	COG4193	domain, Protein
HCC49_RS16780	COG1482	cell wall glycoprotein biosynthetic process
HCC49_RS16785	COG0697	spore germination
HCC49_RS16790	COG0814	amino acid
HCC49_RS16800	COG1215	transferase activity, transferring glycosyl groups
HCC49_RS16805	COG2814	Major facilitator Superfamily
HCC49_RS16810	COG1316	TRANSCRIPTIONal
HCC49_RS16815	COG0561	phosphatase activity
HCC49_RS16820	COG2433	Pfam Transposase IS66
HCC49_RS16825	COG0791	NLP P60 protein
HCC49_RS16835	COG2843	Capsule synthesis protein
HCC49_RS16845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCC49_RS16850	COG0697	spore germination
HCC49_RS16855	COG0814	amino acid
HCC49_RS16865	COG1609	Transcriptional regulator
HCC49_RS16870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCC49_RS16880	COG1129	ABC transporter
HCC49_RS16885	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCC49_RS16890	COG1879	ABC-type sugar transport system periplasmic component
HCC49_RS16895	COG3103	Sh3 type 3 domain protein
HCC49_RS16900	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCC49_RS16905	COG3527	Alpha-acetolactate decarboxylase
HCC49_RS16910	COG0028	Belongs to the TPP enzyme family
HCC49_RS16915	COG0583	DNA-binding transcription factor activity
HCC49_RS16920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCC49_RS16935	COG5337	Spore coat protein CotH
HCC49_RS16945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCC49_RS16955	COG0405	Gamma-glutamyltransferase
HCC49_RS16960	COG1522	sequence-specific DNA binding
HCC49_RS16965	COG2059	Chromate
HCC49_RS16970	COG2059	Chromate
HCC49_RS16980	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCC49_RS16985	COG0583	DNA-binding transcription factor activity
HCC49_RS17000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCC49_RS17005	COG4464	protein tyrosine phosphatase activity
HCC49_RS17010	COG0489	protein tyrosine kinase activity
HCC49_RS17015	COG3944	biosynthesis protein
HCC49_RS17025	COG4715	Zinc finger, swim domain protein
HCC49_RS17030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCC49_RS17035	COG0561	phosphatase activity
HCC49_RS17040	COG1349	DNA-binding transcription factor activity
HCC49_RS17045	COG0629	single-stranded DNA binding
HCC49_RS17070	COG0457	Tetratricopeptide repeat
HCC49_RS17075	COG4786	Flagellar basal body rod
HCC49_RS17080	COG4786	Flagellar basal body rod
HCC49_RS17085	COG1077	Cell shape determining protein MreB Mrl
HCC49_RS17090	COG1609	Transcriptional regulator
HCC49_RS17095	COG1846	Transcriptional regulator
HCC49_RS17100	COG2814	Major facilitator Superfamily
HCC49_RS17105	COG1953	Uracil, thiamine, allantoin
HCC49_RS17110	COG0477	Major facilitator Superfamily
HCC49_RS17115	COG1335	isochorismatase
HCC49_RS17120	COG0004	ammonium transporteR
HCC49_RS17125	COG0347	Belongs to the P(II) protein family
HCC49_RS17130	COG0772	Belongs to the SEDS family
HCC49_RS17135	COG0671	phosphoesterase, PA-phosphatase related
HCC49_RS17145	COG0739	heme binding
HCC49_RS17150	COG1247	-acetyltransferase
HCC49_RS17165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCC49_RS17175	COG0726	polysaccharide deacetylase
HCC49_RS17185	COG1959	2 iron, 2 sulfur cluster binding
HCC49_RS17200	COG0831	urea catabolic process
HCC49_RS17205	COG3237	CsbD-like
HCC49_RS17210	COG1994	Peptidase M50
HCC49_RS17215	COG0457	Tetratricopeptide repeat
HCC49_RS17225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCC49_RS17235	COG2304	oxidoreductase activity
HCC49_RS17240	COG2304	oxidoreductase activity
HCC49_RS17245	COG2385	sporulation resulting in formation of a cellular spore
HCC49_RS17250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCC49_RS17260	COG4836	Membrane
HCC49_RS17330	COG0698	ribose 5-phosphate isomerase
HCC49_RS17335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCC49_RS17345	COG0009	L-threonylcarbamoyladenylate synthase
HCC49_RS17350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCC49_RS17370	COG2890	protein-(glutamine-N5) methyltransferase activity
HCC49_RS17375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCC49_RS17380	COG0346	lactoylglutathione lyase activity
HCC49_RS17385	COG0789	Transcriptional regulator
HCC49_RS17390	COG0679	Auxin Efflux Carrier
HCC49_RS17395	COG0281	malic enzyme
HCC49_RS17410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCC49_RS17415	COG1494	fructose-1,6-bisphosphatase
HCC49_RS17420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCC49_RS17430	COG0191	fructose-bisphosphate aldolase activity
HCC49_RS17435	COG2204	response regulator
HCC49_RS17440	COG4821	SIS domain
HCC49_RS17455	COG0247	lactate metabolic process
HCC49_RS17455	COG2181	nitrate reductase activity
HCC49_RS17460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCC49_RS17475	COG1132	(ABC) transporter
HCC49_RS17480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCC49_RS17490	COG2181	nitrate reductase activity
HCC49_RS17495	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCC49_RS17500	COG1140	nitrate reductase beta subunit
HCC49_RS17505	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCC49_RS17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCC49_RS17520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCC49_RS17525	COG2223	nitrite transmembrane transporter activity
HCC49_RS17535	COG4506	Protein conserved in bacteria
HCC49_RS17545	COG3391	amine dehydrogenase activity
HCC49_RS17550	COG3391	amine dehydrogenase activity
HCC49_RS17555	COG0457	Tetratricopeptide repeat
HCC49_RS17600	COG0010	Belongs to the arginase family
HCC49_RS17605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCC49_RS17610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCC49_RS17625	COG1994	Peptidase M50
HCC49_RS17630	COG1942	4-Oxalocrotonate Tautomerase
HCC49_RS17635	COG1846	Transcriptional regulator
HCC49_RS17640	COG0531	amino acid
HCC49_RS17645	COG3465	dGTPase activity
HCC49_RS17650	COG1078	dGTPase activity
HCC49_RS17665	COG1695	Transcriptional regulator
HCC49_RS17685	COG0583	DNA-binding transcription factor activity
HCC49_RS17695	COG0280	phosphate acetyltransferase
HCC49_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS17710	COG0436	Aminotransferase
HCC49_RS17740	COG2814	Major facilitator Superfamily
HCC49_RS17745	COG2814	Major facilitator Superfamily
HCC49_RS17750	COG0833	amino acid
HCC49_RS17755	COG4187	Peptidase family M20/M25/M40
HCC49_RS17760	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS17765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCC49_RS17775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HCC49_RS17780	COG1091	dTDP-4-dehydrorhamnose reductase activity
HCC49_RS17785	COG1088	dTDP-glucose 4,6-dehydratase activity
HCC49_RS17790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCC49_RS17795	COG3980	spore coat polysaccharide biosynthesis protein
HCC49_RS17800	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HCC49_RS17805	COG2089	acid synthase
HCC49_RS17810	COG0456	acetyltransferase
HCC49_RS17815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCC49_RS17820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCC49_RS17825	COG0463	Glycosyl transferase, family 2
HCC49_RS17835	COG2363	Small membrane protein
HCC49_RS17840	COG2233	PERMEase
HCC49_RS17855	COG1216	Glycosyl transferase, family 2
HCC49_RS17870	COG1695	Transcriptional regulator
HCC49_RS17875	COG0351	phosphomethylpyrimidine kinase
HCC49_RS17885	COG1621	beta-fructofuranosidase activity
HCC49_RS17890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS17890	COG1263	PTS System
HCC49_RS17895	COG3711	transcriptional antiterminator
HCC49_RS17905	COG1404	Belongs to the peptidase S8 family
HCC49_RS17910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCC49_RS17915	COG0778	Nitroreductase
HCC49_RS17920	COG0772	Belongs to the SEDS family
HCC49_RS17925	COG0454	-acetyltransferase
HCC49_RS17945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCC49_RS17950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCC49_RS17955	COG2261	transglycosylase associated protein
HCC49_RS17960	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCC49_RS17970	COG2246	polysaccharide biosynthetic process
HCC49_RS17975	COG1309	transcriptional regulator
HCC49_RS17995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCC49_RS18000	COG2837	iron assimilation
HCC49_RS18025	COG0583	DNA-binding transcription factor activity
HCC49_RS18035	COG1346	cytolysis
HCC49_RS18040	COG4895	conserved protein (DUF2196)
HCC49_RS18045	COG0789	Transcriptional regulator
HCC49_RS18050	COG5504	Zn-dependent protease
HCC49_RS18055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCC49_RS18060	COG0346	lactoylglutathione lyase activity
HCC49_RS18065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS18070	COG1404	Belongs to the peptidase S8 family
HCC49_RS18075	COG1442	glycosyl transferase family 8
HCC49_RS18080	COG2357	RelA SpoT domain protein
HCC49_RS18085	COG1575	Belongs to the MenA family. Type 1 subfamily
HCC49_RS18100	COG1696	Membrane protein involved in D-alanine export
HCC49_RS18110	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCC49_RS18115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCC49_RS18120	COG1486	melibiose metabolic process
HCC49_RS18125	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCC49_RS18130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS18135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS18140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCC49_RS18140	COG3711	transcriptional antiterminator
HCC49_RS18150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS18155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCC49_RS18165	COG0640	Transcriptional regulator
HCC49_RS18170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCC49_RS18175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS18180	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCC49_RS18185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCC49_RS18190	COG2723	6-phospho-beta-galactosidase activity
HCC49_RS18195	COG1940	carbohydrate kinase activity
HCC49_RS18200	COG1482	cell wall glycoprotein biosynthetic process
HCC49_RS18210	COG0753	catalase activity
HCC49_RS18215	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HCC49_RS18220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCC49_RS18225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCC49_RS18230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCC49_RS18235	COG4988	ABC transporter
HCC49_RS18240	COG1294	oxidase, subunit
HCC49_RS18245	COG1271	oxidase subunit
HCC49_RS18250	COG3493	citrate carrier protein
HCC49_RS18255	COG0726	polysaccharide deacetylase
HCC49_RS18260	COG3842	ATPase activity
HCC49_RS18265	COG2508	Transcriptional regulator
HCC49_RS18270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS18280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCC49_RS18295	COG4894	glucomannan catabolic process
HCC49_RS18300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCC49_RS18305	COG0500	methyltransferase
HCC49_RS18310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCC49_RS18325	COG0693	protein deglycase activity
HCC49_RS18325	COG0753	catalase activity
HCC49_RS18330	COG2851	Citrate transporter
HCC49_RS18335	COG2273	Hydrolase Family 16
HCC49_RS18340	COG3711	transcriptional antiterminator
HCC49_RS18345	COG2270	Major facilitator Superfamily
HCC49_RS18350	COG0513	Belongs to the DEAD box helicase family
HCC49_RS18390	COG3209	COG3209 Rhs family protein
HCC49_RS18400	COG0697	spore germination
HCC49_RS18405	COG0589	response to stress
HCC49_RS18410	COG2723	6-phospho-beta-galactosidase activity
HCC49_RS18415	COG1263	PTS System
HCC49_RS18415	COG2190	(PTS) system
HCC49_RS18415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCC49_RS18425	COG3507	Belongs to the glycosyl hydrolase 43 family
HCC49_RS18450	COG0010	Belongs to the arginase family
HCC49_RS18455	COG0833	amino acid
HCC49_RS18460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HCC49_RS18465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCC49_RS18475	COG2390	Transcriptional regulator
HCC49_RS18480	COG0561	phosphatase activity
HCC49_RS18510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCC49_RS18515	COG5294	Protein conserved in bacteria
HCC49_RS18520	COG0577	efflux transmembrane transporter activity
HCC49_RS18525	COG1136	(ABC) transporter
HCC49_RS18530	COG2205	protein histidine kinase activity
HCC49_RS18535	COG0745	RESPONSE REGULATOR receiver
HCC49_RS18550	COG1082	Xylose isomerase domain protein TIM barrel
HCC49_RS18560	COG2814	Major facilitator Superfamily
HCC49_RS18590	COG1349	DNA-binding transcription factor activity
HCC49_RS18595	COG0667	Aldo Keto reductase
HCC49_RS18600	COG2814	Major facilitator Superfamily
HCC49_RS18615	COG1028	Short-chain dehydrogenase reductase Sdr
HCC49_RS18620	COG2197	response regulator
HCC49_RS18625	COG4585	Histidine kinase
HCC49_RS18630	COG3239	Fatty acid desaturase
HCC49_RS18635	COG1309	transcriptional regulator
HCC49_RS18640	COG1012	belongs to the aldehyde dehydrogenase family
HCC49_RS18655	COG0640	Transcriptional regulator
HCC49_RS18660	COG2814	Major facilitator Superfamily
HCC49_RS18665	COG1714	RDD family
HCC49_RS18675	COG0450	alkyl hydroperoxide reductase
HCC49_RS18680	COG3634	alkyl hydroperoxide reductase activity
HCC49_RS18685	COG3177	Filamentation induced by cAMP protein fic
HCC49_RS18690	COG1113	amino acid transport
HCC49_RS18700	COG2080	2 iron, 2 sulfur cluster binding
HCC49_RS18715	COG2068	MobA-Related Protein
HCC49_RS18730	COG1196	nuclear chromosome segregation
HCC49_RS18760	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HCC49_RS18765	COG0667	Aldo Keto reductase
HCC49_RS18770	COG0456	acetyltransferase
HCC49_RS18775	COG0457	Tetratricopeptide repeat
HCC49_RS18780	COG0010	Belongs to the arginase family
HCC49_RS18785	COG0833	amino acid
HCC49_RS18790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCC49_RS18795	COG5658	integral membrane protein
HCC49_RS18800	COG0640	Transcriptional regulator
HCC49_RS18805	COG3829	transcription factor binding
HCC49_RS18815	COG0488	(ABC) transporter
HCC49_RS18830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCC49_RS18845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCC49_RS18850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCC49_RS18855	COG4853	Protein conserved in bacteria
HCC49_RS18860	COG4863	YycH protein
HCC49_RS18865	COG5002	protein histidine kinase activity
HCC49_RS18870	COG0745	RESPONSE REGULATOR receiver
HCC49_RS18900	COG0346	lactoylglutathione lyase activity
HCC49_RS18905	COG0305	Participates in initiation and elongation during chromosome replication
HCC49_RS18920	COG3093	addiction module antidote protein HigA
HCC49_RS18925	COG0297	glycogen (starch) synthase activity
HCC49_RS18935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HCC49_RS18940	COG0438	transferase activity, transferring glycosyl groups
HCC49_RS18960	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HCC49_RS18965	COG4241	membrane
HCC49_RS18975	COG5577	PFAM Coat F domain
HCC49_RS18980	COG1733	regulation of RNA biosynthetic process
HCC49_RS19000	COG0697	spore germination
HCC49_RS19005	COG1621	beta-fructofuranosidase activity
HCC49_RS19010	COG1621	beta-fructofuranosidase activity
HCC49_RS19015	COG1802	Transcriptional regulator
HCC49_RS19020	COG2318	DinB family
HCC49_RS19025	COG2211	Major facilitator Superfamily
HCC49_RS19035	COG0778	Nitroreductase
HCC49_RS19040	COG1846	Transcriptional regulator
HCC49_RS19045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCC49_RS19050	COG1846	Transcriptional regulator
HCC49_RS19055	COG2153	protein acetylation
HCC49_RS19060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCC49_RS19065	COG0697	spore germination
HCC49_RS19070	COG1090	epimerase
HCC49_RS19080	COG1959	2 iron, 2 sulfur cluster binding
HCC49_RS19085	COG1396	sequence-specific DNA binding
HCC49_RS19090	COG2856	Zn peptidase
HCC49_RS19100	COG1331	Highly conserved protein containing a thioredoxin domain
HCC49_RS19105	COG1331	Highly conserved protein containing a thioredoxin domain
HCC49_RS19110	COG1266	CAAX protease self-immunity
HCC49_RS19115	COG2814	Major facilitator Superfamily
HCC49_RS19115	COG0477	Major facilitator Superfamily
HCC49_RS19120	COG0346	lactoylglutathione lyase activity
HCC49_RS19125	COG1609	Transcriptional regulator
HCC49_RS19130	COG0708	Exodeoxyribonuclease III
HCC49_RS19135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCC49_RS19140	COG2169	Transcriptional regulator
HCC49_RS19150	COG0629	single-stranded DNA binding
HCC49_RS19160	COG0012	GTP binding
HCC49_RS19165	COG0243	molybdopterin cofactor binding
HCC49_RS19170	COG4481	Protein conserved in bacteria
HCC49_RS19175	COG3949	Membrane
HCC49_RS19190	COG1475	DNA binding
HCC49_RS19195	COG1192	Involved in chromosome partitioning
HCC49_RS19220	COG1847	R3H domain protein
HCC49_RS19225	COG0706	membrane insertase activity
HCC49_RS19245	COG0592	DNA-directed DNA polymerase activity
HCC49_RS19250	COG2501	S4 domain
HCC49_RS19265	COG0187	DNA topoisomerase II activity
HCC49_RS19270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner