locus-tag	class	description
DA378_RS00005	COG3829	transcription factor binding
DA378_RS00005	COG3290	protein histidine kinase activity
DA378_RS00010	COG0280	phosphate acetyltransferase
DA378_RS00015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA378_RS00020	COG3426	butyrate kinase activity
DA378_RS00025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA378_RS00030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA378_RS00035	COG0022	dehydrogenase e1 component
DA378_RS00040	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA378_RS00045	COG1597	lipid kinase activity
DA378_RS00055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS00060	COG0765	amino acid transport
DA378_RS00065	COG1126	abc transporter atp-binding protein
DA378_RS00070	COG4129	membrane
DA378_RS00075	COG1376	ErfK ybiS ycfS ynhG family protein
DA378_RS00080	COG0346	lactoylglutathione lyase activity
DA378_RS00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA378_RS00090	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA378_RS00095	COG0706	membrane insertase activity
DA378_RS00110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DA378_RS00115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DA378_RS00130	COG0596	Alpha beta hydrolase
DA378_RS00155	COG0250	Participates in transcription elongation, termination and antitermination
DA378_RS00165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA378_RS00165	COG2070	2-Nitropropane dioxygenase
DA378_RS00180	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS00195	COG3321	synthase
DA378_RS00195	COG0300	oxidoreductase activity
DA378_RS00195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00205	COG0300	oxidoreductase activity
DA378_RS00205	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS00205	COG3321	synthase
DA378_RS00210	COG0300	oxidoreductase activity
DA378_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS00210	COG3321	synthase
DA378_RS00210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00215	COG3321	synthase
DA378_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS00215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS00215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS00220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS00220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS00220	COG3321	synthase
DA378_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS00225	COG2124	cytochrome p450
DA378_RS00230	COG3425	synthase
DA378_RS00235	COG1024	Enoyl-CoA hydratase
DA378_RS00240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA378_RS00245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS00250	COG0300	oxidoreductase activity
DA378_RS00255	COG3048	D-serine ammonia-lyase activity
DA378_RS00265	COG0346	lactoylglutathione lyase activity
DA378_RS00275	COG0628	permease
DA378_RS00290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DA378_RS00295	COG0456	acetyltransferase
DA378_RS00300	COG2329	Antibiotic biosynthesis monooxygenase
DA378_RS00305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DA378_RS00305	COG0456	acetyltransferase
DA378_RS00310	COG4918	Iron-sulphur cluster biosynthesis
DA378_RS00320	COG1073	alpha beta
DA378_RS00330	COG0667	Aldo Keto reductase
DA378_RS00340	COG0494	nUDIX hydrolase
DA378_RS00345	COG1379	DNA repair
DA378_RS00350	COG1396	sequence-specific DNA binding
DA378_RS00355	COG0252	asparaginase activity
DA378_RS00360	COG1027	Aspartate ammonia-lyase
DA378_RS00365	COG1757	Na H antiporter
DA378_RS00370	COG0281	malic enzyme
DA378_RS00385	COG1300	Membrane
DA378_RS00390	COG0735	belongs to the Fur family
DA378_RS00400	COG4974	Belongs to the 'phage' integrase family
DA378_RS00405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA378_RS00410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA378_RS00415	COG1686	Belongs to the peptidase S11 family
DA378_RS00420	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS00430	COG1191	sigma factor activity
DA378_RS00450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA378_RS00465	COG0697	spore germination
DA378_RS00470	COG0019	diaminopimelate decarboxylase activity
DA378_RS00475	COG4086	secreted protein
DA378_RS00480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA378_RS00490	COG0681	Belongs to the peptidase S26 family
DA378_RS00500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA378_RS00500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA378_RS00505	COG0307	riboflavin synthase, alpha
DA378_RS00520	COG0456	acetyltransferase
DA378_RS00530	COG1547	Domain of unknown function (DUF309)
DA378_RS00555	COG1686	Belongs to the peptidase S11 family
DA378_RS00560	COG2715	membrane protein required for spore maturation
DA378_RS00565	COG0700	Nucleoside recognition
DA378_RS00570	COG1187	pseudouridine synthase activity
DA378_RS00575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS00580	COG1333	cytochrome c biogenesis protein
DA378_RS00585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA378_RS00590	COG0745	RESPONSE REGULATOR receiver
DA378_RS00595	COG5002	protein histidine kinase activity
DA378_RS00600	COG1595	DNA-templated transcription, initiation
DA378_RS00610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA378_RS00615	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DA378_RS00620	COG1141	Ferredoxin
DA378_RS00625	COG4955	Helix-turn-helix domain
DA378_RS00630	COG0514	ATP-dependent DNA helicase (RecQ)
DA378_RS00635	COG1266	CAAX protease self-immunity
DA378_RS00640	COG1388	LysM domain
DA378_RS00650	COG1408	metallophosphoesterase
DA378_RS00655	COG4862	establishment of competence for transformation
DA378_RS00660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA378_RS00665	COG0492	ferredoxin-NADP+ reductase activity
DA378_RS00670	COG2339	peptidase activity
DA378_RS00675	COG3773	Cell wall hydrolase
DA378_RS00675	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS00680	COG2959	enzyme of heme biosynthesis
DA378_RS00685	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DA378_RS00695	COG0539	negative regulation of cytoplasmic translation
DA378_RS00735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DA378_RS00740	COG0776	regulation of translation
DA378_RS00755	COG0142	geranyltranstransferase activity
DA378_RS00765	COG0142	geranyltranstransferase activity
DA378_RS00770	COG0105	UTP biosynthetic process
DA378_RS00775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DA378_RS00790	COG4401	Chorismate mutase type I
DA378_RS00795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA378_RS00830	COG0287	Prephenate dehydrogenase
DA378_RS00840	COG0457	Tetratricopeptide repeat
DA378_RS00855	COG0723	plastoquinol--plastocyanin reductase activity
DA378_RS00860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA378_RS00865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA378_RS00865	COG2010	Cytochrome c
DA378_RS00870	COG4347	Protein of unknown function (DUF1405)
DA378_RS00880	COG2140	Oxalate decarboxylase
DA378_RS00885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS00890	COG1694	Mazg nucleotide pyrophosphohydrolase
DA378_RS00905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA378_RS00910	COG0438	transferase activity, transferring glycosyl groups
DA378_RS00940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA378_RS00940	COG1199	ATP-dependent helicase activity
DA378_RS00950	COG5353	protein conserved in bacteria
DA378_RS00955	COG0436	Aminotransferase
DA378_RS00965	COG3935	DnaD domain protein
DA378_RS00970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DA378_RS00980	COG4499	WXG100 protein secretion system (Wss), protein YukC
DA378_RS00980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA378_RS01020	COG0071	Belongs to the small heat shock protein (HSP20) family
DA378_RS01025	COG2190	(PTS) system
DA378_RS01030	COG1205	dead DEAH box helicase
DA378_RS01030	COG1111	helicase
DA378_RS01035	COG3359	exonuclease
DA378_RS01060	COG0116	Belongs to the methyltransferase superfamily
DA378_RS01080	COG1199	ATP-dependent helicase activity
DA378_RS01085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DA378_RS01095	COG2233	PERMEase
DA378_RS01105	COG1335	isochorismatase
DA378_RS01130	COG3424	synthase
DA378_RS01135	COG1755	Isoprenylcysteine carboxyl methyltransferase
DA378_RS01145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DA378_RS01160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA378_RS01170	COG0328	RNA-DNA hybrid ribonuclease activity
DA378_RS01175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA378_RS01180	COG0328	RNA-DNA hybrid ribonuclease activity
DA378_RS01200	COG1278	Cold shock
DA378_RS01205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA378_RS01215	COG0386	Belongs to the glutathione peroxidase family
DA378_RS01220	COG1418	mRNA catabolic process
DA378_RS01225	COG1413	lyase activity
DA378_RS01240	COG2521	methyltransferase
DA378_RS01240	COG2136	Putative SAM-dependent methyltransferase
DA378_RS01255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA378_RS01260	COG0204	Acyl-transferase
DA378_RS01265	COG1272	protein, Hemolysin III
DA378_RS01270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DA378_RS01275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA378_RS01285	COG1999	signal sequence binding
DA378_RS01290	COG2755	lipolytic protein G-D-S-L family
DA378_RS01295	COG4698	Protein conserved in bacteria
DA378_RS01300	COG1846	Transcriptional regulator
DA378_RS01320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA378_RS01335	COG1525	nuclease
DA378_RS01340	COG4282	regulation of fungal-type cell wall biogenesis
DA378_RS01345	COG5444	nuclease activity
DA378_RS01370	COG0457	Tetratricopeptide repeat
DA378_RS01375	COG1388	LysM domain
DA378_RS01410	COG1086	Polysaccharide biosynthesis protein
DA378_RS01420	COG4641	Protein conserved in bacteria
DA378_RS01435	COG0463	Glycosyl transferase, family 2
DA378_RS01440	COG0456	acetyltransferase
DA378_RS01460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA378_RS01465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DA378_RS01470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DA378_RS01475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA378_RS01480	COG0456	acetyltransferase
DA378_RS01485	COG1509	lysine 2,3-aminomutase activity
DA378_RS01520	COG0671	phosphoesterase, PA-phosphatase related
DA378_RS01540	COG1876	peptidase activity
DA378_RS01550	COG2226	methyltransferase
DA378_RS01555	COG0793	Belongs to the peptidase S41A family
DA378_RS01555	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS01560	COG2188	Transcriptional regulator
DA378_RS01565	COG2723	6-phospho-beta-galactosidase activity
DA378_RS01575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA378_RS01585	COG0346	lactoylglutathione lyase activity
DA378_RS01590	COG0400	carboxylic ester hydrolase activity
DA378_RS01595	COG0778	Nitroreductase
DA378_RS01600	COG1733	regulation of RNA biosynthetic process
DA378_RS01610	COG1942	4-Oxalocrotonate Tautomerase
DA378_RS01625	COG2962	Rard protein
DA378_RS01635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA378_RS01640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA378_RS01645	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS01650	COG0534	Mate efflux family protein
DA378_RS01655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DA378_RS01660	COG1819	glycosyl
DA378_RS01665	COG1388	LysM domain
DA378_RS01665	COG0791	NLP P60 protein
DA378_RS01670	COG2032	superoxide dismutase activity
DA378_RS01675	COG0714	Associated with various cellular activities
DA378_RS01680	COG4548	von Willebrand factor, type A
DA378_RS01690	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA378_RS01695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS01700	COG0385	Bile acid
DA378_RS01705	COG0733	neurotransmitter:sodium symporter activity
DA378_RS01710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA378_RS01715	COG1657	PFAM Prenyltransferase squalene oxidase
DA378_RS01720	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS01750	COG0071	Belongs to the small heat shock protein (HSP20) family
DA378_RS01765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA378_RS01770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA378_RS01780	COG0514	ATP-dependent DNA helicase (RecQ)
DA378_RS01785	COG1388	LysM domain
DA378_RS01785	COG3584	3D domain protein
DA378_RS01795	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA378_RS01810	COG2322	membrane
DA378_RS01815	COG0741	lytic transglycosylase activity
DA378_RS01820	COG0640	Transcriptional regulator
DA378_RS01830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS01835	COG1309	transcriptional regulator
DA378_RS01840	COG0662	Cupin 2, conserved barrel domain protein
DA378_RS01840	COG2207	Transcriptional regulator
DA378_RS01845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA378_RS01850	COG1733	regulation of RNA biosynthetic process
DA378_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS01880	COG0243	molybdopterin cofactor binding
DA378_RS01885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA378_RS01890	COG1070	Carbohydrate kinase
DA378_RS01895	COG2814	Major facilitator Superfamily
DA378_RS01905	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DA378_RS01910	COG0300	oxidoreductase activity
DA378_RS01925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA378_RS01930	COG0583	DNA-binding transcription factor activity
DA378_RS01935	COG0070	glutamate synthase
DA378_RS01935	COG0067	glutamate synthase
DA378_RS01935	COG0069	glutamate synthase activity
DA378_RS01940	COG0493	'glutamate synthase
DA378_RS01965	COG0640	Transcriptional regulator
DA378_RS01970	COG2814	Major facilitator Superfamily
DA378_RS01975	COG0405	Gamma-glutamyltransferase
DA378_RS01980	COG0166	Belongs to the GPI family
DA378_RS01985	COG0582	viral genome integration into host DNA
DA378_RS02000	COG0534	Mate efflux family protein
DA378_RS02005	COG2017	converts alpha-aldose to the beta-anomer
DA378_RS02010	COG2027	D-alanyl-D-alanine carboxypeptidase
DA378_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DA378_RS02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02050	COG1649	PFAM Uncharacterised BCR, COG1649
DA378_RS02055	COG1960	acyl-CoA dehydrogenase activity
DA378_RS02060	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS02065	COG0439	Biotin carboxylase
DA378_RS02070	COG0511	ligase activity, forming carbon-carbon bonds
DA378_RS02075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA378_RS02080	COG1024	Enoyl-CoA hydratase
DA378_RS02085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA378_RS02090	COG0586	Pfam SNARE associated Golgi protein
DA378_RS02095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA378_RS02100	COG2246	polysaccharide biosynthetic process
DA378_RS02110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA378_RS02130	COG2124	cytochrome p450
DA378_RS02135	COG2610	gluconate transmembrane transporter activity
DA378_RS02140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DA378_RS02145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DA378_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02180	COG3507	Belongs to the glycosyl hydrolase 43 family
DA378_RS02190	COG0745	RESPONSE REGULATOR receiver
DA378_RS02195	COG2205	protein histidine kinase activity
DA378_RS02230	COG2271	Major facilitator Superfamily
DA378_RS02235	COG1609	Transcriptional regulator
DA378_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02250	COG0800	Aldolase
DA378_RS02255	COG1063	alcohol dehydrogenase
DA378_RS02265	COG1115	amino acid carrier protein
DA378_RS02275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA378_RS02280	COG0187	DNA topoisomerase II activity
DA378_RS02285	COG1832	CoA-binding protein
DA378_RS02295	COG4841	protein insertion into membrane
DA378_RS02305	COG0824	Thioesterase
DA378_RS02325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS02330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DA378_RS02345	COG0071	Belongs to the small heat shock protein (HSP20) family
DA378_RS02355	COG4846	Membrane protein involved in cytochrome C biogenesis
DA378_RS02360	COG2201	protein-glutamate methylesterase activity
DA378_RS02365	COG0785	Cytochrome C biogenesis protein
DA378_RS02385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DA378_RS02395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA378_RS02425	COG4195	phage-related replication protein
DA378_RS02430	COG0756	dUTP diphosphatase activity
DA378_RS02435	COG5434	Belongs to the glycosyl hydrolase 28 family
DA378_RS02450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA378_RS02460	COG3397	chitin binding
DA378_RS02490	COG1064	alcohol dehydrogenase
DA378_RS02515	COG3848	Pyruvate phosphate dikinase
DA378_RS02515	COG0574	Belongs to the PEP-utilizing enzyme family
DA378_RS02520	COG1070	Carbohydrate kinase
DA378_RS02535	COG3507	Belongs to the glycosyl hydrolase 43 family
DA378_RS02540	COG2211	Major facilitator Superfamily
DA378_RS02550	COG0174	glutamine synthetase
DA378_RS02555	COG0789	Transcriptional regulator
DA378_RS02560	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DA378_RS02565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA378_RS02570	COG0464	growth
DA378_RS02580	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS02585	COG4112	unkown
DA378_RS02590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA378_RS02595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA378_RS02635	COG2076	Multidrug Resistance protein
DA378_RS02645	COG1764	response to oxidative stress
DA378_RS02650	COG4195	phage-related replication protein
DA378_RS02660	COG1404	Belongs to the peptidase S8 family
DA378_RS02670	COG3619	membrane
DA378_RS02675	COG3209	COG3209 Rhs family protein
DA378_RS02680	COG2124	cytochrome p450
DA378_RS02685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS02685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA378_RS02685	COG3321	synthase
DA378_RS02685	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DA378_RS02690	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02690	COG4221	oxidoreductase activity
DA378_RS02690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02690	COG3321	synthase
DA378_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02695	COG3321	synthase
DA378_RS02695	COG3321	synthase
DA378_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS02695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS02695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02700	COG0300	oxidoreductase activity
DA378_RS02700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS02700	COG4221	oxidoreductase activity
DA378_RS02700	COG3321	synthase
DA378_RS02705	COG0300	oxidoreductase activity
DA378_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS02705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS02705	COG3321	synthase
DA378_RS02710	COG1024	Enoyl-CoA hydratase
DA378_RS02715	COG1024	Enoyl-CoA hydratase
DA378_RS02720	COG3425	synthase
DA378_RS02725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS02775	COG4550	Control of competence regulator ComK, YlbF/YmcA
DA378_RS02795	COG2359	stage V sporulation protein S
DA378_RS02800	COG1692	metallophosphoesterase
DA378_RS02810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA378_RS02825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA378_RS02830	COG1426	Protein conserved in bacteria
DA378_RS02845	COG0300	oxidoreductase activity
DA378_RS02850	COG0612	Peptidase, M16
DA378_RS02855	COG0612	Peptidase, M16
DA378_RS02860	COG1033	growth of symbiont in host cell
DA378_RS02860	COG2409	Drug exporters of the RND superfamily
DA378_RS02865	COG1846	Transcriptional regulator
DA378_RS02870	COG2814	Major facilitator Superfamily
DA378_RS02875	COG2188	Transcriptional regulator
DA378_RS02880	COG1674	ftsk spoiiie
DA378_RS02880	COG4980	gas vesicle protein
DA378_RS02890	COG0740	serine-type endopeptidase activity
DA378_RS02895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DA378_RS02905	COG0527	aspartate kinase activity
DA378_RS02910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA378_RS02915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA378_RS02920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA378_RS02925	COG1873	PFAM PRC-barrel domain
DA378_RS02930	COG0612	Peptidase, M16
DA378_RS02935	COG0726	polysaccharide deacetylase
DA378_RS02950	COG0196	riboflavin kinase activity
DA378_RS02965	COG1550	Protein conserved in bacteria
DA378_RS02975	COG1358	cellular component organization or biogenesis
DA378_RS02980	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DA378_RS02985	COG0195	Participates in both transcription termination and antitermination
DA378_RS02995	COG2176	DNA-directed DNA polymerase activity
DA378_RS03005	COG0750	zinc metalloprotease
DA378_RS03015	COG4589	Belongs to the CDS family
DA378_RS03020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA378_RS03050	COG1191	sigma factor activity
DA378_RS03060	COG1776	CheC inhibitor of MCP methylation
DA378_RS03065	COG0835	chemotaxis
DA378_RS03070	COG2198	Histidine kinase
DA378_RS03070	COG0643	Histidine kinase
DA378_RS03075	COG2201	protein-glutamate methylesterase activity
DA378_RS03080	COG0455	bacterial-type flagellum organization
DA378_RS03085	COG1419	protein localization to endoplasmic reticulum
DA378_RS03090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA378_RS03095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA378_RS03100	COG1684	flagellar biosynthetic protein fliR
DA378_RS03105	COG1987	bacterial-type flagellum assembly
DA378_RS03110	COG1338	Plays a role in the flagellum-specific transport system
DA378_RS03115	COG3190	flagellar
DA378_RS03120	COG2201	protein-glutamate methylesterase activity
DA378_RS03125	COG1776	CheC inhibitor of MCP methylation
DA378_RS03125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA378_RS03130	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA378_RS03135	COG1580	Controls the rotational direction of flagella during chemotaxis
DA378_RS03140	COG1582	Flagellar protein (FlbD)
DA378_RS03145	COG4786	Flagellar basal body rod
DA378_RS03150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA378_RS03155	COG3144	bacterial-type flagellum assembly
DA378_RS03160	COG3334	PFAM MgtE intracellular
DA378_RS03165	COG2882	bacterial-type flagellum organization
DA378_RS03170	COG1157	protein secretion by the type III secretion system
DA378_RS03175	COG1317	bacterial-type flagellum organization
DA378_RS03180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA378_RS03185	COG1766	The M ring may be actively involved in energy transduction
DA378_RS03190	COG1677	Flagellar hook-basal body complex protein FliE
DA378_RS03195	COG1558	bacterial-type flagellum-dependent cell motility
DA378_RS03200	COG1815	bacterial-type flagellum-dependent cell motility
DA378_RS03220	COG4974	Belongs to the 'phage' integrase family
DA378_RS03230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA378_RS03235	COG0758	DNA mediated transformation
DA378_RS03240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DA378_RS03250	COG2257	FlhB HrpN YscU SpaS Family
DA378_RS03265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA378_RS03290	COG1837	Belongs to the UPF0109 family
DA378_RS03300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA378_RS03315	COG0552	protein localization to endoplasmic reticulum
DA378_RS03320	COG1196	nuclear chromosome segregation
DA378_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS03340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA378_RS03355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DA378_RS03360	COG1760	l-serine dehydratase
DA378_RS03365	COG1760	l-serine dehydratase
DA378_RS03370	COG1461	Dihydroxyacetone kinase
DA378_RS03375	COG1302	Protein conserved in bacteria
DA378_RS03390	COG1564	THIamine pyrophosphokinase
DA378_RS03395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA378_RS03405	COG0515	serine threonine protein kinase
DA378_RS03405	COG2815	serine threonine protein kinase
DA378_RS03410	COG0631	protein serine/threonine phosphatase activity
DA378_RS03420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA378_RS03420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA378_RS03430	COG0242	peptide deformylase activity
DA378_RS03435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA378_RS03440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA378_RS03450	COG0194	GDP metabolic process
DA378_RS03460	COG1561	YicC-like family, N-terminal region
DA378_RS03465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA378_RS03480	COG1648	precorrin-2 dehydrogenase activity
DA378_RS03490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA378_RS03505	COG0306	phosphate transporter
DA378_RS03515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA378_RS03520	COG0284	orotidine-5'-phosphate decarboxylase activity
DA378_RS03535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA378_RS03540	COG0505	Belongs to the CarA family
DA378_RS03545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA378_RS03555	COG2233	PERMEase
DA378_RS03565	COG0564	pseudouridine synthase activity
DA378_RS03575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA378_RS03580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA378_RS03590	COG3599	regulation of cell shape
DA378_RS03595	COG2302	S4 RNA-binding domain
DA378_RS03600	COG0762	integral membrane protein
DA378_RS03610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DA378_RS03615	COG1496	oxidoreductase activity
DA378_RS03620	COG1873	PFAM PRC-barrel domain
DA378_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA378_RS03630	COG1119	ATPase activity
DA378_RS03635	COG1191	sigma factor activity
DA378_RS03640	COG1191	sigma factor activity
DA378_RS03650	COG4412	M6 family metalloprotease domain protein
DA378_RS03650	COG1404	Belongs to the peptidase S8 family
DA378_RS03655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA378_RS03660	COG0849	cell division
DA378_RS03665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA378_RS03680	COG0772	Belongs to the SEDS family
DA378_RS03700	COG0768	penicillin binding
DA378_RS03705	COG0768	penicillin binding
DA378_RS03710	COG4839	cell division protein FtsL
DA378_RS03730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA378_RS03750	COG1399	metal-binding, possibly nucleic acid-binding protein
DA378_RS03760	COG3480	Lon protease (S16) C-terminal proteolytic domain
DA378_RS03765	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA378_RS03770	COG3314	Sporulation integral membrane protein YlbJ
DA378_RS03780	COG0742	ribosomal rna small subunit methyltransferase
DA378_RS03795	COG3679	Belongs to the UPF0342 family
DA378_RS03810	COG2340	Cysteine-rich secretory protein family
DA378_RS03815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DA378_RS03825	COG3336	cytochrome c oxidase
DA378_RS03830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA378_RS03835	COG1845	cytochrome c oxidase, subunit III
DA378_RS03840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA378_RS03845	COG2010	Cytochrome c
DA378_RS03845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA378_RS03860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DA378_RS03865	COG0772	Belongs to the SEDS family
DA378_RS03875	COG2066	Belongs to the glutaminase family
DA378_RS03880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA378_RS03885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DA378_RS03895	COG4896	Protein conserved in bacteria
DA378_RS03905	COG1217	gtp-binding protein TYPA
DA378_RS03930	COG3227	Zinc metalloprotease (Elastase)
DA378_RS03940	COG0483	inositol monophosphate 1-phosphatase activity
DA378_RS03965	COG1982	Orn Lys Arg decarboxylase major
DA378_RS03980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS03985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA378_RS03990	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA378_RS03995	COG0022	dehydrogenase e1 component
DA378_RS04000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA378_RS04005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA378_RS04010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS04010	COG4221	oxidoreductase activity
DA378_RS04010	COG3321	synthase
DA378_RS04015	COG4221	oxidoreductase activity
DA378_RS04015	COG0300	oxidoreductase activity
DA378_RS04015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS04015	COG3321	synthase
DA378_RS04020	COG3321	synthase
DA378_RS04020	COG4221	oxidoreductase activity
DA378_RS04020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS04020	COG0300	oxidoreductase activity
DA378_RS04025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS04025	COG4221	oxidoreductase activity
DA378_RS04025	COG3321	synthase
DA378_RS04025	COG0300	oxidoreductase activity
DA378_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS04030	COG4221	oxidoreductase activity
DA378_RS04030	COG3321	synthase
DA378_RS04030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS04035	COG3321	synthase
DA378_RS04035	COG4221	oxidoreductase activity
DA378_RS04035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA378_RS04035	COG0300	oxidoreductase activity
DA378_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS04040	COG3321	synthase
DA378_RS04040	COG4221	oxidoreductase activity
DA378_RS04040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS04055	COG0497	DNA recombination
DA378_RS04065	COG0242	peptide deformylase activity
DA378_RS04070	COG0561	phosphatase activity
DA378_RS04080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DA378_RS04090	COG0569	domain protein
DA378_RS04095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DA378_RS04095	COG2105	PFAM AIG2 family protein
DA378_RS04100	COG3852	Histidine kinase
DA378_RS04105	COG2002	toxin-antitoxin pair type II binding
DA378_RS04115	COG1077	Cell shape determining protein MreB Mrl
DA378_RS04125	COG2309	aminopeptidase activity
DA378_RS04130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA378_RS04135	COG0488	(ABC) transporter
DA378_RS04145	COG0681	Belongs to the peptidase S26 family
DA378_RS04150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA378_RS04150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA378_RS04150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS04155	COG1105	Belongs to the carbohydrate kinase PfkB family
DA378_RS04160	COG1349	DNA-binding transcription factor activity
DA378_RS04165	COG0577	efflux transmembrane transporter activity
DA378_RS04170	COG1136	(ABC) transporter
DA378_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA378_RS04185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DA378_RS04190	COG0314	molybdopterin synthase activity
DA378_RS04195	COG1763	Mo-molybdopterin cofactor biosynthetic process
DA378_RS04200	COG0303	'Molybdopterin
DA378_RS04205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA378_RS04225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS04230	COG0668	transmembrane transport
DA378_RS04250	COG0716	FMN binding
DA378_RS04260	COG0716	FMN binding
DA378_RS04265	COG0583	DNA-binding transcription factor activity
DA378_RS04270	COG0517	IMP dehydrogenase activity
DA378_RS04280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DA378_RS04285	COG4703	Protein of unknown function (DUF1797)
DA378_RS04290	COG2200	EAL domain
DA378_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS04305	COG1408	metallophosphoesterase
DA378_RS04310	COG1376	ErfK ybiS ycfS ynhG family protein
DA378_RS04315	COG2814	Major facilitator Superfamily
DA378_RS04325	COG0835	chemotaxis
DA378_RS04325	COG0784	Response regulator, receiver
DA378_RS04335	COG0436	Aminotransferase
DA378_RS04340	COG4191	Histidine kinase
DA378_RS04345	COG0768	penicillin binding
DA378_RS04350	COG2340	Cysteine-rich secretory protein family
DA378_RS04355	COG0347	Belongs to the P(II) protein family
DA378_RS04365	COG2084	Dehydrogenase
DA378_RS04370	COG0840	transmembrane signaling receptor activity
DA378_RS04375	COG1533	DNA photolyase activity
DA378_RS04385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA378_RS04390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS04395	COG2190	(PTS) system
DA378_RS04395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA378_RS04395	COG1263	PTS System
DA378_RS04400	COG3711	transcriptional antiterminator
DA378_RS04405	COG1609	Transcriptional regulator
DA378_RS04410	COG0006	proline dipeptidase activity
DA378_RS04415	COG2217	Heavy metal translocating P-type atpase
DA378_RS04420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS04425	COG2244	polysaccharide biosynthetic process
DA378_RS04430	COG3773	Cell wall hydrolase
DA378_RS04440	COG4873	Protein conserved in bacteria
DA378_RS04455	COG0602	queuosine metabolic process
DA378_RS04460	COG0720	synthase
DA378_RS04475	COG3949	Membrane
DA378_RS04485	COG0542	response to heat
DA378_RS04490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA378_RS04495	COG1360	Flagellar Motor Protein
DA378_RS04500	COG1846	Transcriptional regulator
DA378_RS04505	COG3852	Histidine kinase
DA378_RS04535	COG0436	Aminotransferase
DA378_RS04540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA378_RS04560	COG5002	protein histidine kinase activity
DA378_RS04565	COG3594	Acyltransferase
DA378_RS04575	COG2323	membrane
DA378_RS04580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA378_RS04605	COG1191	sigma factor activity
DA378_RS04610	COG0861	Integral membrane protein TerC family
DA378_RS04615	COG0586	Pfam SNARE associated Golgi protein
DA378_RS04620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DA378_RS04625	COG1793	dna ligase
DA378_RS04625	COG3285	dna ligase
DA378_RS04630	COG0726	polysaccharide deacetylase
DA378_RS04635	COG1846	Transcriptional regulator
DA378_RS04650	COG0789	Transcriptional regulator
DA378_RS04655	COG2239	Acts as a magnesium transporter
DA378_RS04675	COG1388	LysM domain
DA378_RS04675	COG3858	chitin binding
DA378_RS04680	COG4721	ABC-type cobalt transport system, permease component
DA378_RS04685	COG1122	ATPase activity
DA378_RS04690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DA378_RS04695	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS04700	COG1404	Belongs to the peptidase S8 family
DA378_RS04710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA378_RS04715	COG2814	Major facilitator Superfamily
DA378_RS04725	COG0457	Tetratricopeptide repeat
DA378_RS04725	COG0463	Glycosyl transferase, family 2
DA378_RS04740	COG1764	response to oxidative stress
DA378_RS04745	COG1846	Transcriptional regulator
DA378_RS04750	COG1764	response to oxidative stress
DA378_RS04760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA378_RS04765	COG0788	formyltetrahydrofolate deformylase activity
DA378_RS04770	COG2076	Multidrug Resistance protein
DA378_RS04775	COG2076	Multidrug Resistance protein
DA378_RS04780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA378_RS04785	COG1607	acyl-coa hydrolase
DA378_RS04790	COG1834	amidinotransferase
DA378_RS04795	COG2706	6-phosphogluconolactonase activity
DA378_RS04800	COG4608	Belongs to the ABC transporter superfamily
DA378_RS04805	COG0791	NLP P60 protein
DA378_RS04810	COG4948	Mandelate Racemase Muconate Lactonizing
DA378_RS04815	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA378_RS04820	COG4166	transmembrane transport
DA378_RS04825	COG0444	Belongs to the ABC transporter superfamily
DA378_RS04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA378_RS04835	COG0601	transmembrane transport
DA378_RS04840	COG2362	D-Aminopeptidase
DA378_RS04845	COG0477	Major facilitator Superfamily
DA378_RS04850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA378_RS04855	COG0463	Glycosyl transferase, family 2
DA378_RS04860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA378_RS04865	COG0346	lactoylglutathione lyase activity
DA378_RS04870	COG0531	amino acid
DA378_RS04875	COG1392	Phosphate transport regulator
DA378_RS04880	COG0306	phosphate transporter
DA378_RS04895	COG5632	N-Acetylmuramoyl-L-alanine amidase
DA378_RS04895	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS04935	COG3778	Protein conserved in bacteria
DA378_RS04940	COG3299	homolog of phage Mu protein gp47
DA378_RS04945	COG3628	GPW Gp25 family protein
DA378_RS04955	COG4193	domain, Protein
DA378_RS04960	COG1652	LysM domain
DA378_RS04965	COG5412	phage tail tape measure protein
DA378_RS04965	COG3953	SLT domain
DA378_RS04965	COG5412	phage tail tape measure protein
DA378_RS04965	COG3953	SLT domain
DA378_RS04965	COG5412	phage tail tape measure protein
DA378_RS04965	COG3953	SLT domain
DA378_RS05015	COG4653	Phage capsid family
DA378_RS05020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DA378_RS05025	COG5518	Phage portal protein
DA378_RS05030	COG1783	phage Terminase large subunit
DA378_RS05035	COG3728	DNA packaging
DA378_RS05035	COG5484	DNA packaging
DA378_RS05040	COG1595	DNA-templated transcription, initiation
DA378_RS05055	COG1484	DNA-dependent DNA replication
DA378_RS05060	COG1522	sequence-specific DNA binding
DA378_RS05070	COG1396	sequence-specific DNA binding
DA378_RS05075	COG2856	Zn peptidase
DA378_RS05080	COG4195	phage-related replication protein
DA378_RS05090	COG5632	N-Acetylmuramoyl-L-alanine amidase
DA378_RS05090	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS05090	COG1388	LysM domain
DA378_RS05095	COG0457	Tetratricopeptide repeat
DA378_RS05100	COG2318	DinB family
DA378_RS05105	COG0730	response to heat
DA378_RS05130	COG2197	response regulator
DA378_RS05135	COG4585	Histidine kinase
DA378_RS05155	COG2205	protein histidine kinase activity
DA378_RS05155	COG2770	Histidine kinase
DA378_RS05160	COG0745	RESPONSE REGULATOR receiver
DA378_RS05165	COG2721	sulfolactate sulfo-lyase activity
DA378_RS05170	COG0246	Mannitol dehydrogenase
DA378_RS05175	COG1609	Transcriptional regulator
DA378_RS05180	COG2211	Major facilitator Superfamily
DA378_RS05190	COG1252	NADH dehydrogenase
DA378_RS05200	COG4297	protein containing double-stranded beta helix domain
DA378_RS05205	COG0697	spore germination
DA378_RS05210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA378_RS05215	COG0390	transport system, permease component
DA378_RS05220	COG1587	Uroporphyrinogen-III synthase
DA378_RS05230	COG1819	glycosyl
DA378_RS05235	COG2124	cytochrome p450
DA378_RS05240	COG2427	Protein of unknown function (DUF1641)
DA378_RS05245	COG3383	formate dehydrogenase (NAD+) activity
DA378_RS05255	COG2205	protein histidine kinase activity
DA378_RS05270	COG1285	pathogenesis
DA378_RS05285	COG1349	DNA-binding transcription factor activity
DA378_RS05295	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA378_RS05300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS05300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS05305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA378_RS05310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA378_RS05315	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DA378_RS05325	COG1846	Transcriptional regulator
DA378_RS05335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA378_RS05340	COG2367	Beta-lactamase
DA378_RS05345	COG0346	lactoylglutathione lyase activity
DA378_RS05355	COG5444	nuclease activity
DA378_RS05370	COG0626	cystathionine gamma-synthase activity
DA378_RS05375	COG0626	cystathionine gamma-synthase activity
DA378_RS05380	COG2382	esterase
DA378_RS05390	COG2153	protein acetylation
DA378_RS05400	COG1131	(ABC) transporter
DA378_RS05420	COG0210	DNA helicase
DA378_RS05475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA378_RS05480	COG0351	phosphomethylpyrimidine kinase
DA378_RS05485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA378_RS05495	COG2104	thiamine diphosphate biosynthetic process
DA378_RS05500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA378_RS05505	COG0352	thiamine-phosphate diphosphorylase activity
DA378_RS05510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DA378_RS05515	COG0475	glutathione-regulated potassium exporter activity
DA378_RS05515	COG0569	domain protein
DA378_RS05530	COG0564	pseudouridine synthase activity
DA378_RS05535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA378_RS05540	COG2357	RelA SpoT domain protein
DA378_RS05550	COG4116	CYTH
DA378_RS05555	COG0741	lytic transglycosylase activity
DA378_RS05560	COG2346	COG2346, Truncated hemoglobins
DA378_RS05565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DA378_RS05570	COG1164	Oligoendopeptidase f
DA378_RS05575	COG4469	Competence protein
DA378_RS05580	COG4862	establishment of competence for transformation
DA378_RS05585	COG0861	Integral membrane protein TerC family
DA378_RS05590	COG1393	Belongs to the ArsC family
DA378_RS05595	COG0456	acetyltransferase
DA378_RS05605	COG4608	Belongs to the ABC transporter superfamily
DA378_RS05610	COG0444	Belongs to the ABC transporter superfamily
DA378_RS05615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA378_RS05620	COG0601	transmembrane transport
DA378_RS05630	COG0180	Tryptophanyl-tRNA synthetase
DA378_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA378_RS05645	COG0601	transmembrane transport
DA378_RS05655	COG4608	Belongs to the ABC transporter superfamily
DA378_RS05660	COG0444	Belongs to the ABC transporter superfamily
DA378_RS05665	COG5504	Zn-dependent protease
DA378_RS05670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA378_RS05675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA378_RS05690	COG1744	ABC transporter substrate-binding protein PnrA-like
DA378_RS05700	COG2267	carboxylic ester hydrolase activity
DA378_RS05720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DA378_RS05725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA378_RS05730	COG0505	Belongs to the CarA family
DA378_RS05735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA378_RS05745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DA378_RS05755	COG2271	Major facilitator Superfamily
DA378_RS05760	COG0277	FAD linked oxidase domain protein
DA378_RS05770	COG2151	metal-sulfur cluster biosynthetic enzyme
DA378_RS05775	COG1073	alpha beta
DA378_RS05780	COG0561	phosphatase activity
DA378_RS05795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS05800	COG1307	EDD domain protein, DegV family
DA378_RS05810	COG0840	transmembrane signaling receptor activity
DA378_RS05815	COG1744	ABC transporter substrate-binding protein PnrA-like
DA378_RS05820	COG2996	Protein conserved in bacteria
DA378_RS05830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DA378_RS05830	COG0646	methionine synthase
DA378_RS05835	COG2153	protein acetylation
DA378_RS05840	COG1357	PFAM Pentapeptide repeats (8 copies)
DA378_RS05850	COG2318	DinB family
DA378_RS05855	COG0673	inositol 2-dehydrogenase activity
DA378_RS05860	COG1609	Transcriptional regulator
DA378_RS05865	COG1917	Cupin 2, conserved barrel domain protein
DA378_RS05865	COG2207	Transcriptional regulator
DA378_RS05870	COG0534	Mate efflux family protein
DA378_RS05875	COG1562	ergosterol biosynthetic process
DA378_RS05880	COG0367	asparagine synthase
DA378_RS05900	COG0179	Fumarylacetoacetate (FAA) hydrolase
DA378_RS05940	COG1403	HNH endonuclease
DA378_RS05945	COG0419	ATPase involved in DNA repair
DA378_RS05950	COG0420	3'-5' exonuclease activity
DA378_RS05965	COG2323	membrane
DA378_RS05970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DA378_RS05980	COG2814	Major facilitator Superfamily
DA378_RS05985	COG3180	Ammonia monooxygenase
DA378_RS05990	COG1846	Transcriptional regulator
DA378_RS05995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA378_RS06000	COG0681	Belongs to the peptidase S26 family
DA378_RS06005	COG0398	Pfam SNARE associated Golgi protein
DA378_RS06020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA378_RS06040	COG5646	InterPro IPR014922
DA378_RS06050	COG4903	ComK protein
DA378_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS06065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA378_RS06065	COG0723	plastoquinol--plastocyanin reductase activity
DA378_RS06070	COG0840	transmembrane signaling receptor activity
DA378_RS06075	COG1268	BioY protein
DA378_RS06080	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS06085	COG0183	Belongs to the thiolase family
DA378_RS06090	COG0406	alpha-ribazole phosphatase activity
DA378_RS06095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DA378_RS06105	COG1404	Belongs to the peptidase S8 family
DA378_RS06110	COG0501	Belongs to the peptidase M48B family
DA378_RS06120	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS06125	COG0702	epimerase
DA378_RS06130	COG0095	Lipoate-protein ligase
DA378_RS06135	COG1234	tRNA 3'-trailer cleavage
DA378_RS06145	COG1301	dicarboxylic acid transport
DA378_RS06150	COG1363	Peptidase, m42
DA378_RS06160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA378_RS06165	COG1511	domain protein
DA378_RS06170	COG1309	transcriptional regulator
DA378_RS06175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DA378_RS06180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DA378_RS06190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA378_RS06195	COG2329	Antibiotic biosynthesis monooxygenase
DA378_RS06200	COG3069	C4-dicarboxylate transmembrane transporter activity
DA378_RS06205	COG1473	amidohydrolase
DA378_RS06215	COG4473	ABC transporter
DA378_RS06220	COG1131	(ABC) transporter
DA378_RS06225	COG0537	adenosine 5'-monophosphoramidase activity
DA378_RS06230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DA378_RS06245	COG4980	gas vesicle protein
DA378_RS06285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA378_RS06300	COG4717	serine-type aminopeptidase activity
DA378_RS06305	COG0420	3'-5' exonuclease activity
DA378_RS06310	COG1668	transmembrane transport
DA378_RS06315	COG4152	abc transporter atp-binding protein
DA378_RS06335	COG0490	domain, Protein
DA378_RS06340	COG0475	glutathione-regulated potassium exporter activity
DA378_RS06350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA378_RS06355	COG0561	phosphatase activity
DA378_RS06360	COG4335	DNA alkylation repair
DA378_RS06375	COG0189	ligase activity
DA378_RS06380	COG0189	ligase activity
DA378_RS06400	COG0702	epimerase
DA378_RS06405	COG1132	(ABC) transporter
DA378_RS06410	COG1132	(ABC) transporter
DA378_RS06415	COG0589	response to stress
DA378_RS06425	COG3226	Transcriptional regulator
DA378_RS06430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA378_RS06435	COG0726	polysaccharide deacetylase
DA378_RS06440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DA378_RS06445	COG0668	transmembrane transport
DA378_RS06455	COG0584	glycerophosphoryl diester phosphodiesterase
DA378_RS06460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA378_RS06465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA378_RS06470	COG1253	flavin adenine dinucleotide binding
DA378_RS06475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA378_RS06480	COG0436	Aminotransferase
DA378_RS06485	COG0789	Transcriptional regulator
DA378_RS06490	COG1253	flavin adenine dinucleotide binding
DA378_RS06495	COG0204	Acyl-transferase
DA378_RS06500	COG1595	DNA-templated transcription, initiation
DA378_RS06515	COG0733	neurotransmitter:sodium symporter activity
DA378_RS06520	COG0531	amino acid
DA378_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS06530	COG0372	Belongs to the citrate synthase family
DA378_RS06535	COG0583	DNA-binding transcription factor activity
DA378_RS06540	COG0791	NLP P60 protein
DA378_RS06540	COG1388	LysM domain
DA378_RS06545	COG1785	Belongs to the alkaline phosphatase family
DA378_RS06550	COG2719	SpoVR family
DA378_RS06555	COG0668	transmembrane transport
DA378_RS06560	COG1959	2 iron, 2 sulfur cluster binding
DA378_RS06565	COG1388	LysM domain
DA378_RS06565	COG0791	NLP P60 protein
DA378_RS06580	COG0431	NADPH-dependent FMN reductase
DA378_RS06595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA378_RS06600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA378_RS06610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA378_RS06615	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DA378_RS06620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA378_RS06625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA378_RS06625	COG3153	acetyltransferase
DA378_RS06630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA378_RS06635	COG0517	IMP dehydrogenase activity
DA378_RS06645	COG0564	pseudouridine synthase activity
DA378_RS06650	COG3764	Sortase (surface protein transpeptidase)
DA378_RS06655	COG1525	nuclease
DA378_RS06655	COG0737	Belongs to the 5'-nucleotidase family
DA378_RS06655	COG4085	toxin activity
DA378_RS06660	COG5577	PFAM Coat F domain
DA378_RS06680	COG1823	symporter activity
DA378_RS06685	COG3706	GGDEF domain
DA378_RS06690	COG1464	Belongs to the NlpA lipoprotein family
DA378_RS06700	COG1278	Cold shock
DA378_RS06705	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA378_RS06710	COG1131	(ABC) transporter
DA378_RS06715	COG1131	(ABC) transporter
DA378_RS06720	COG1725	Transcriptional regulator
DA378_RS06735	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA378_RS06740	COG2814	Major facilitator Superfamily
DA378_RS06745	COG1566	PFAM secretion protein HlyD family protein
DA378_RS06750	COG1846	Transcriptional regulator
DA378_RS06765	COG2766	serine protein kinase
DA378_RS06770	COG1664	Polymer-forming cytoskeletal
DA378_RS06775	COG1664	Polymer-forming cytoskeletal
DA378_RS06780	COG0789	Transcriptional regulator
DA378_RS06785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA378_RS06795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DA378_RS06800	COG3382	B3 4 domain protein
DA378_RS06810	COG1476	TRANSCRIPTIONal
DA378_RS06830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA378_RS06835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA378_RS06840	COG1116	anion transmembrane transporter activity
DA378_RS06855	COG0753	catalase activity
DA378_RS06860	COG4608	Belongs to the ABC transporter superfamily
DA378_RS06865	COG0444	Belongs to the ABC transporter superfamily
DA378_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA378_RS06875	COG0601	transmembrane transport
DA378_RS06880	COG0747	negative chemotaxis
DA378_RS06890	COG0277	FAD linked oxidase domain protein
DA378_RS06900	COG3340	Belongs to the peptidase S51 family
DA378_RS07015	COG0735	belongs to the Fur family
DA378_RS07020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DA378_RS07030	COG4129	membrane
DA378_RS07035	COG1132	(ABC) transporter
DA378_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS07065	COG1194	a g-specific adenine glycosylase
DA378_RS07070	COG1988	membrane-bound metal-dependent
DA378_RS07075	COG4485	Bacterial membrane protein, YfhO
DA378_RS07080	COG0463	Glycosyl transferase, family 2
DA378_RS07085	COG0596	Alpha beta hydrolase
DA378_RS07090	COG5658	integral membrane protein
DA378_RS07095	COG3103	Sh3 type 3 domain protein
DA378_RS07110	COG3591	Belongs to the peptidase S1B family
DA378_RS07120	COG2814	Major facilitator Superfamily
DA378_RS07135	COG1090	epimerase
DA378_RS07150	COG0778	Nitroreductase
DA378_RS07155	COG0384	phenazine biosynthesis protein PhzF
DA378_RS07160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DA378_RS07160	COG0392	lysyltransferase activity
DA378_RS07165	COG1846	Transcriptional regulator
DA378_RS07170	COG2814	Major facilitator Superfamily
DA378_RS07175	COG2318	DinB family
DA378_RS07180	COG2732	(Barnase) inhibitor
DA378_RS07185	COG0574	Belongs to the PEP-utilizing enzyme family
DA378_RS07185	COG3848	Pyruvate phosphate dikinase
DA378_RS07190	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DA378_RS07195	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA378_RS07200	COG1695	Transcriptional regulator
DA378_RS07210	COG2514	catechol 2,3-dioxygenase activity
DA378_RS07215	COG2259	Doxx family
DA378_RS07220	COG1132	(ABC) transporter
DA378_RS07225	COG1132	(ABC) transporter
DA378_RS07230	COG1263	PTS System
DA378_RS07230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA378_RS07235	COG1737	Transcriptional regulator
DA378_RS07240	COG1486	melibiose metabolic process
DA378_RS07250	COG3284	Transcriptional regulator
DA378_RS07255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA378_RS07260	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA378_RS07265	COG0022	dehydrogenase e1 component
DA378_RS07270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA378_RS07275	COG4637	Psort location Cytoplasmic, score
DA378_RS07280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA378_RS07295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA378_RS07300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DA378_RS07305	COG0598	Magnesium transport protein CorA
DA378_RS07315	COG2084	Dehydrogenase
DA378_RS07320	COG0726	polysaccharide deacetylase
DA378_RS07330	COG0535	radical SAM domain protein
DA378_RS07335	COG0668	transmembrane transport
DA378_RS07345	COG0387	Pfam Sodium calcium exchanger
DA378_RS07350	COG0477	Major facilitator Superfamily
DA378_RS07355	COG1295	ribonuclease BN
DA378_RS07360	COG4980	gas vesicle protein
DA378_RS07365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA378_RS07375	COG2814	Major facilitator Superfamily
DA378_RS07390	COG1609	Transcriptional regulator
DA378_RS07395	COG0693	protein deglycase activity
DA378_RS07400	COG0737	Belongs to the 5'-nucleotidase family
DA378_RS07415	COG0778	Nitroreductase
DA378_RS07420	COG2188	Transcriptional regulator
DA378_RS07425	COG0366	Alpha amylase catalytic
DA378_RS07430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA378_RS07430	COG1263	PTS System
DA378_RS07445	COG0071	Belongs to the small heat shock protein (HSP20) family
DA378_RS07455	COG1368	sulfuric ester hydrolase activity
DA378_RS07465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA378_RS07465	COG1263	PTS System
DA378_RS07470	COG0024	Methionine aminopeptidase
DA378_RS07490	COG2258	MOSC domain
DA378_RS07500	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DA378_RS07505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS07510	COG2851	Citrate transporter
DA378_RS07515	COG3181	Tripartite tricarboxylate transporter family receptor
DA378_RS07520	COG4565	transcriptional regulatory protein
DA378_RS07525	COG3290	protein histidine kinase activity
DA378_RS07545	COG0471	metal ion transport
DA378_RS07550	COG3866	Pectate lyase
DA378_RS07565	COG2130	NADP-dependent
DA378_RS07575	COG0513	Belongs to the DEAD box helicase family
DA378_RS07580	COG0488	(ABC) transporter
DA378_RS07585	COG2814	Major facilitator Superfamily
DA378_RS07590	COG0789	Transcriptional regulator
DA378_RS07595	COG0488	(ABC) transporter
DA378_RS07600	COG0457	Tetratricopeptide repeat
DA378_RS07600	COG0463	Glycosyl transferase, family 2
DA378_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS07610	COG0840	transmembrane signaling receptor activity
DA378_RS07615	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS07620	COG0531	amino acid
DA378_RS07625	COG2223	nitrite transmembrane transporter activity
DA378_RS07630	COG1442	glycosyl transferase family 8
DA378_RS07635	COG1216	Glycosyl transferase, family 2
DA378_RS07640	COG1442	glycosyl transferase family 8
DA378_RS07645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS07650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA378_RS07655	COG1368	sulfuric ester hydrolase activity
DA378_RS07660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA378_RS07660	COG2124	cytochrome p450
DA378_RS07670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA378_RS07675	COG1846	Transcriptional regulator
DA378_RS07680	COG0670	Belongs to the BI1 family
DA378_RS07685	COG0196	riboflavin kinase activity
DA378_RS07690	COG5583	Uncharacterized small protein (DUF2292)
DA378_RS07695	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS07700	COG0346	lactoylglutathione lyase activity
DA378_RS07705	COG2329	Antibiotic biosynthesis monooxygenase
DA378_RS07710	COG2323	membrane
DA378_RS07720	COG0454	-acetyltransferase
DA378_RS07725	COG3546	catalase activity
DA378_RS07760	COG5444	nuclease activity
DA378_RS07785	COG1131	(ABC) transporter
DA378_RS07795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA378_RS07800	COG1597	lipid kinase activity
DA378_RS07805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA378_RS07810	COG1309	transcriptional regulator
DA378_RS07830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA378_RS07835	COG1285	pathogenesis
DA378_RS07840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA378_RS07845	COG4851	CamS sex pheromone cAM373 precursor
DA378_RS07855	COG0210	DNA helicase
DA378_RS07875	COG4496	protein, YerC YecD
DA378_RS07880	COG1470	cell adhesion involved in biofilm formation
DA378_RS07885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DA378_RS07895	COG0151	Belongs to the GarS family
DA378_RS07900	COG0138	bifunctional purine biosynthesis protein purh
DA378_RS07905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA378_RS07915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA378_RS07930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA378_RS07935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DA378_RS07940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA378_RS07945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DA378_RS07950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DA378_RS07970	COG3064	Membrane
DA378_RS07975	COG2252	PERMEase
DA378_RS07995	COG1305	Transglutaminase-like
DA378_RS08000	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DA378_RS08005	COG0714	Associated with various cellular activities
DA378_RS08010	COG1113	amino acid transport
DA378_RS08015	COG2132	Multicopper oxidase
DA378_RS08025	COG0823	Involved in the tonB-independent uptake of proteins
DA378_RS08030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA378_RS08035	COG1063	alcohol dehydrogenase
DA378_RS08040	COG1595	DNA-templated transcription, initiation
DA378_RS08050	COG2755	lipolytic protein G-D-S-L family
DA378_RS08050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DA378_RS08055	COG4260	virion core protein, lumpy skin disease virus
DA378_RS08060	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DA378_RS08065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA378_RS08070	COG1842	Phage shock protein A
DA378_RS08080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA378_RS08085	COG2211	Major facilitator Superfamily
DA378_RS08090	COG1063	alcohol dehydrogenase
DA378_RS08095	COG0457	Tetratricopeptide repeat
DA378_RS08130	COG4824	toxin secretion phage lysis holin
DA378_RS08245	COG5484	DNA packaging
DA378_RS08260	COG1595	DNA-templated transcription, initiation
DA378_RS08355	COG1484	DNA-dependent DNA replication
DA378_RS08360	COG3935	DnaD domain protein
DA378_RS08425	COG1396	sequence-specific DNA binding
DA378_RS08435	COG2856	Zn peptidase
DA378_RS08455	COG1266	CAAX protease self-immunity
DA378_RS08465	COG0805	protein transport
DA378_RS08470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA378_RS08485	COG0488	(ABC) transporter
DA378_RS08490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DA378_RS08495	COG0456	acetyltransferase
DA378_RS08500	COG1214	PFAM Peptidase M22, glycoprotease
DA378_RS08505	COG0802	atpase or kinase
DA378_RS08510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DA378_RS08550	COG2814	Major facilitator Superfamily
DA378_RS08555	COG0604	alcohol dehydrogenase
DA378_RS08560	COG3832	glyoxalase III activity
DA378_RS08570	COG0531	amino acid
DA378_RS08575	COG1309	transcriptional regulator
DA378_RS08580	COG2076	Multidrug Resistance protein
DA378_RS08585	COG2076	Multidrug Resistance protein
DA378_RS08590	COG2807	transmembrane transport
DA378_RS08595	COG2186	Transcriptional regulator
DA378_RS08600	COG2188	Transcriptional regulator
DA378_RS08605	COG2814	Major facilitator Superfamily
DA378_RS08610	COG1388	LysM domain
DA378_RS08615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA378_RS08630	COG1819	glycosyl
DA378_RS08635	COG1802	Transcriptional regulator
DA378_RS08645	COG2226	methyltransferase
DA378_RS08650	COG1051	belongs to the nudix hydrolase family
DA378_RS08655	COG0697	spore germination
DA378_RS08660	COG0789	Transcriptional regulator
DA378_RS08660	COG4978	Transcriptional regulator
DA378_RS08665	COG0456	acetyltransferase
DA378_RS08670	COG0730	response to heat
DA378_RS08680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA378_RS08685	COG2814	Major facilitator Superfamily
DA378_RS08695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS08700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA378_RS08705	COG0488	(ABC) transporter
DA378_RS08710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA378_RS08715	COG2409	Drug exporters of the RND superfamily
DA378_RS08720	COG2197	response regulator
DA378_RS08725	COG4585	Histidine kinase
DA378_RS08735	COG5577	PFAM Coat F domain
DA378_RS08740	COG1063	alcohol dehydrogenase
DA378_RS08750	COG5577	PFAM Coat F domain
DA378_RS08760	COG1309	transcriptional regulator
DA378_RS08765	COG2814	Major facilitator Superfamily
DA378_RS08780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA378_RS08790	COG0789	Transcriptional regulator
DA378_RS08795	COG1064	alcohol dehydrogenase
DA378_RS08820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA378_RS08855	COG0277	FAD linked oxidase domain protein
DA378_RS08875	COG0477	Major facilitator Superfamily
DA378_RS08880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA378_RS08890	COG1917	Cupin 2, conserved barrel domain protein
DA378_RS08890	COG2207	Transcriptional regulator
DA378_RS08895	COG1473	amidohydrolase
DA378_RS08900	COG0814	amino acid
DA378_RS08905	COG0251	oxidation-reduction process
DA378_RS08910	COG1802	Transcriptional regulator
DA378_RS08915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA378_RS08925	COG3621	Patatin-like phospholipase
DA378_RS08940	COG1794	racemase activity, acting on amino acids and derivatives
DA378_RS08945	COG0730	response to heat
DA378_RS08950	COG0425	Belongs to the sulfur carrier protein TusA family
DA378_RS08955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS08955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA378_RS08960	COG0425	Belongs to the sulfur carrier protein TusA family
DA378_RS08960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA378_RS08965	COG1054	Belongs to the UPF0176 family
DA378_RS08970	COG2210	Belongs to the sulfur carrier protein TusA family
DA378_RS08975	COG1937	Protein conserved in bacteria
DA378_RS08985	COG1278	Cold shock
DA378_RS08990	COG2910	NAD(P)H-binding
DA378_RS08995	COG1959	2 iron, 2 sulfur cluster binding
DA378_RS09000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA378_RS09010	COG2030	dehydratase
DA378_RS09020	COG1846	Transcriptional regulator
DA378_RS09025	COG1764	response to oxidative stress
DA378_RS09035	COG0477	Major facilitator Superfamily
DA378_RS09040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA378_RS09055	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA378_RS09105	COG2183	response to ionizing radiation
DA378_RS09110	COG2208	phosphoserine phosphatase activity
DA378_RS09115	COG1191	sigma factor activity
DA378_RS09125	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS09130	COG2208	phosphoserine phosphatase activity
DA378_RS09135	COG2172	sigma factor antagonist activity
DA378_RS09140	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS09145	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS09150	COG2337	Toxic component of a toxin-antitoxin (TA) module
DA378_RS09155	COG0864	Transcriptional regulator
DA378_RS09160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA378_RS09165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DA378_RS09175	COG0705	Rhomboid family
DA378_RS09180	COG3428	Bacterial PH domain
DA378_RS09185	COG3402	PFAM membrane-flanked domain
DA378_RS09190	COG0513	Belongs to the DEAD box helicase family
DA378_RS09195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DA378_RS09205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS09210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA378_RS09225	COG1960	acyl-CoA dehydrogenase activity
DA378_RS09235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA378_RS09240	COG1131	(ABC) transporter
DA378_RS09245	COG0628	permease
DA378_RS09250	COG1301	dicarboxylic acid transport
DA378_RS09255	COG4565	transcriptional regulatory protein
DA378_RS09260	COG3290	protein histidine kinase activity
DA378_RS09265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DA378_RS09270	COG3546	catalase activity
DA378_RS09275	COG2329	Antibiotic biosynthesis monooxygenase
DA378_RS09280	COG0662	Cupin 2, conserved barrel domain protein
DA378_RS09285	COG3729	General stress protein
DA378_RS09290	COG2217	Heavy metal translocating P-type atpase
DA378_RS09295	COG2076	Multidrug Resistance protein
DA378_RS09305	COG4876	unkown
DA378_RS09320	COG1914	H( )-stimulated, divalent metal cation uptake system
DA378_RS09350	COG0028	Belongs to the TPP enzyme family
DA378_RS09360	COG0531	amino acid
DA378_RS09370	COG1215	transferase activity, transferring glycosyl groups
DA378_RS09375	COG5298	Protein conserved in bacteria
DA378_RS09380	COG3706	GGDEF domain
DA378_RS09385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DA378_RS09390	COG0551	DNA topoisomerase type I activity
DA378_RS09390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA378_RS09395	COG1522	sequence-specific DNA binding
DA378_RS09400	COG2814	Major facilitator Superfamily
DA378_RS09410	COG3871	stress protein (general stress protein 26)
DA378_RS09415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA378_RS09420	COG1917	Cupin 2, conserved barrel domain protein
DA378_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS09430	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS09435	COG3711	transcriptional antiterminator
DA378_RS09440	COG4989	oxidoreductase activity
DA378_RS09445	COG0768	penicillin binding
DA378_RS09450	COG2329	Antibiotic biosynthesis monooxygenase
DA378_RS09460	COG2755	lipolytic protein G-D-S-L family
DA378_RS09465	COG1414	Transcriptional regulator
DA378_RS09470	COG1984	allophanate hydrolase subunit 2
DA378_RS09475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DA378_RS09485	COG1914	H( )-stimulated, divalent metal cation uptake system
DA378_RS09495	COG0561	phosphatase activity
DA378_RS09505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA378_RS09515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS09530	COG1349	DNA-binding transcription factor activity
DA378_RS09535	COG1276	copper resistance
DA378_RS09535	COG2372	response to copper ion
DA378_RS09540	COG4549	nuclear export factor GLE1
DA378_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS09550	COG4975	Glucose uptake
DA378_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS09560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA378_RS09565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA378_RS09570	COG0640	Transcriptional regulator
DA378_RS09575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA378_RS09580	COG0778	Nitroreductase
DA378_RS09585	COG1309	transcriptional regulator
DA378_RS09590	COG2814	Major facilitator Superfamily
DA378_RS09595	COG4607	ABC-type enterochelin transport system periplasmic component
DA378_RS09600	COG4604	ABC transporter, ATP-binding protein
DA378_RS09605	COG4605	iron ion homeostasis
DA378_RS09610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS09620	COG0527	aspartate kinase activity
DA378_RS09635	COG0457	Tetratricopeptide repeat
DA378_RS09640	COG3850	Histidine kinase
DA378_RS09640	COG5002	protein histidine kinase activity
DA378_RS09645	COG0745	RESPONSE REGULATOR receiver
DA378_RS09650	COG0577	efflux transmembrane transporter activity
DA378_RS09655	COG1136	(ABC) transporter
DA378_RS09660	COG2079	MmgE PrpD family protein
DA378_RS09665	COG1473	amidohydrolase
DA378_RS09670	COG1126	abc transporter atp-binding protein
DA378_RS09675	COG0765	amino acid transport
DA378_RS09680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS09685	COG0456	acetyltransferase
DA378_RS09690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS09695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA378_RS09705	COG0697	spore germination
DA378_RS09715	COG5434	Belongs to the glycosyl hydrolase 28 family
DA378_RS09720	COG3104	oligopeptide transport
DA378_RS09735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DA378_RS09740	COG0163	prenyltransferase activity
DA378_RS09745	COG0583	DNA-binding transcription factor activity
DA378_RS09750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS09755	COG0765	amino acid transport
DA378_RS09760	COG1126	abc transporter atp-binding protein
DA378_RS09765	COG2364	Membrane
DA378_RS09780	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DA378_RS09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS09790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS09795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS09800	COG1733	regulation of RNA biosynthetic process
DA378_RS09805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DA378_RS09810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DA378_RS09815	COG3209	COG3209 Rhs family protein
DA378_RS09830	COG2723	6-phospho-beta-galactosidase activity
DA378_RS09840	COG1714	RDD family
DA378_RS09845	COG1063	alcohol dehydrogenase
DA378_RS09850	COG0523	cobalamin synthesis protein
DA378_RS09855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA378_RS09860	COG2146	nitrite reductase [NAD(P)H] activity
DA378_RS09865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA378_RS09865	COG1587	Uroporphyrinogen-III synthase
DA378_RS09875	COG2508	Transcriptional regulator
DA378_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS09890	COG0506	proline dehydrogenase activity
DA378_RS09895	COG3541	Predicted nucleotidyltransferase
DA378_RS09900	COG3458	cephalosporin-C deacetylase activity
DA378_RS09905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA378_RS09910	COG2271	Major facilitator Superfamily
DA378_RS09920	COG1660	Displays ATPase and GTPase activities
DA378_RS09935	COG3665	Urea carboxylase-associated protein
DA378_RS09940	COG1113	amino acid transport
DA378_RS09945	COG3403	YqcI/YcgG family
DA378_RS09950	COG1280	lysine exporter protein (LysE YggA)
DA378_RS09955	COG1846	Transcriptional regulator
DA378_RS09960	COG2814	Major facilitator Superfamily
DA378_RS09970	COG0366	Alpha amylase catalytic
DA378_RS09980	COG1288	antiporter activity
DA378_RS09985	COG1473	amidohydrolase
DA378_RS09990	COG2113	Glycine betaine
DA378_RS09995	COG4176	ABC-type proline glycine betaine transport system permease component
DA378_RS10000	COG4175	Glycine betaine
DA378_RS10000	COG0517	IMP dehydrogenase activity
DA378_RS10005	COG0477	Major facilitator Superfamily
DA378_RS10010	COG3853	Toxic anion resistance protein (TelA)
DA378_RS10020	COG0861	Integral membrane protein TerC family
DA378_RS10025	COG2310	stress, protein
DA378_RS10030	COG2310	stress, protein
DA378_RS10035	COG2310	stress, protein
DA378_RS10040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS10045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA378_RS10050	COG1121	(ABC) transporter
DA378_RS10055	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA378_RS10060	COG0366	Alpha amylase catalytic
DA378_RS10065	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS10070	COG0457	Tetratricopeptide repeat
DA378_RS10075	COG1876	peptidase activity
DA378_RS10080	COG1595	DNA-templated transcription, initiation
DA378_RS10085	COG1595	DNA-templated transcription, initiation
DA378_RS10095	COG0667	Aldo Keto reductase
DA378_RS10100	COG3012	SEC-C Motif Domain Protein
DA378_RS10100	COG1405	negative regulation of cell septum assembly
DA378_RS10105	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DA378_RS10110	COG0252	asparaginase activity
DA378_RS10115	COG1309	transcriptional regulator
DA378_RS10120	COG0477	Major facilitator Superfamily
DA378_RS10125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA378_RS10135	COG0805	protein transport
DA378_RS10140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA378_RS10145	COG3540	Alkaline phosphatase
DA378_RS10155	COG3773	Cell wall hydrolase
DA378_RS10175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS10180	COG2259	Doxx family
DA378_RS10185	COG0346	lactoylglutathione lyase activity
DA378_RS10190	COG0778	Nitroreductase
DA378_RS10195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA378_RS10205	COG3173	Aminoglycoside phosphotransferase
DA378_RS10210	COG0784	Response regulator, receiver
DA378_RS10215	COG4191	Histidine kinase
DA378_RS10220	COG2066	Belongs to the glutaminase family
DA378_RS10225	COG1115	amino acid carrier protein
DA378_RS10230	COG2040	homocysteine
DA378_RS10235	COG0833	amino acid
DA378_RS10240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA378_RS10245	COG1301	dicarboxylic acid transport
DA378_RS10260	COG0688	phosphatidylethanolamine metabolic process
DA378_RS10265	COG0586	Pfam SNARE associated Golgi protein
DA378_RS10270	COG1183	phosphatidylcholine synthase activity
DA378_RS10280	COG0371	Dehydrogenase
DA378_RS10295	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS10305	COG2368	4-hydroxyphenylacetate
DA378_RS10320	COG2271	Major facilitator Superfamily
DA378_RS10325	COG0584	glycerophosphoryl diester phosphodiesterase
DA378_RS10330	COG0531	amino acid
DA378_RS10370	COG1131	(ABC) transporter
DA378_RS10375	COG2197	response regulator
DA378_RS10380	COG4585	Histidine kinase
DA378_RS10385	COG1011	Hydrolase
DA378_RS10390	COG1113	amino acid transport
DA378_RS10395	COG1846	Transcriptional regulator
DA378_RS10400	COG1380	Effector of murein hydrolase LrgA
DA378_RS10405	COG1346	cytolysis
DA378_RS10450	COG4856	YbbR-like protein
DA378_RS10455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DA378_RS10460	COG5662	AntiSigma factor
DA378_RS10465	COG1595	DNA-templated transcription, initiation
DA378_RS10495	COG1683	Conserved Protein
DA378_RS10500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA378_RS10510	COG1263	PTS System
DA378_RS10510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA378_RS10515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA378_RS10520	COG1472	Belongs to the glycosyl hydrolase 3 family
DA378_RS10525	COG3876	Protein conserved in bacteria
DA378_RS10530	COG2207	Transcriptional regulator
DA378_RS10530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA378_RS10535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA378_RS10540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS10550	COG2819	hydrolase of the alpha beta superfamily
DA378_RS10555	COG0385	Bile acid
DA378_RS10560	COG0659	secondary active sulfate transmembrane transporter activity
DA378_RS10575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA378_RS10580	COG0738	Major facilitator superfamily
DA378_RS10640	COG0726	polysaccharide deacetylase
DA378_RS10645	COG2194	sulfuric ester hydrolase activity
DA378_RS10655	COG0489	protein tyrosine kinase activity
DA378_RS10660	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS10670	COG2318	DinB family
DA378_RS10675	COG2226	methyltransferase
DA378_RS10695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DA378_RS10700	COG1122	ATPase activity
DA378_RS10705	COG1122	ATPase activity
DA378_RS10730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DA378_RS10745	COG0024	Methionine aminopeptidase
DA378_RS10755	COG0201	protein transport
DA378_RS10865	COG0596	Alpha beta hydrolase
DA378_RS10890	COG1358	cellular component organization or biogenesis
DA378_RS10905	COG2813	Specifically methylates the guanine in position
DA378_RS10930	COG0250	Participates in transcription elongation, termination and antitermination
DA378_RS10935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA378_RS10945	COG1595	DNA-templated transcription, initiation
DA378_RS10950	COG3688	RNA-binding protein containing a PIN domain
DA378_RS10955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA378_RS10960	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DA378_RS10970	COG1045	serine acetyltransferase
DA378_RS10995	COG4956	integral membrane protein (PIN domain superfamily)
DA378_RS11000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DA378_RS11005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DA378_RS11010	COG0542	response to heat
DA378_RS11020	COG3880	PFAM UvrB UvrC protein
DA378_RS11025	COG4463	regulation of RNA biosynthetic process
DA378_RS11105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DA378_RS11110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA378_RS11115	COG1396	sequence-specific DNA binding
DA378_RS11120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA378_RS11125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA378_RS11130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA378_RS11135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA378_RS11140	COG0512	Glutamine amidotransferase of anthranilate synthase
DA378_RS11145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA378_RS11150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA378_RS11155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA378_RS11170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA378_RS11175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DA378_RS11180	COG0037	tRNA processing
DA378_RS11185	COG0515	serine threonine protein kinase
DA378_RS11190	COG2304	oxidoreductase activity
DA378_RS11195	COG2208	phosphoserine phosphatase activity
DA378_RS11210	COG1098	S1 RNA binding domain
DA378_RS11215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA378_RS11230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DA378_RS11235	COG3956	TIGRFAM MazG family protein
DA378_RS11240	COG2244	polysaccharide biosynthetic process
DA378_RS11245	COG2002	toxin-antitoxin pair type II binding
DA378_RS11250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DA378_RS11270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA378_RS11285	COG0251	oxidation-reduction process
DA378_RS11290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DA378_RS11305	COG4466	Protein conserved in bacteria
DA378_RS11315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA378_RS11320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DA378_RS11325	COG3583	domain protein
DA378_RS11325	COG3584	3D domain protein
DA378_RS11330	COG0084	hydrolase, TatD family'
DA378_RS11335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA378_RS11335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA378_RS11340	COG2002	toxin-antitoxin pair type II binding
DA378_RS11345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA378_RS11355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DA378_RS11365	COG1774	PSP1 C-terminal conserved region
DA378_RS11370	COG0470	DNA polymerase III
DA378_RS11375	COG1728	Protein conserved in bacteria
DA378_RS11380	COG3870	Protein conserved in bacteria
DA378_RS11390	COG1982	Orn Lys Arg decarboxylase major
DA378_RS11395	COG3853	Toxic anion resistance protein (TelA)
DA378_RS11400	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DA378_RS11450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DA378_RS11455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DA378_RS11465	COG0590	tRNA wobble adenosine to inosine editing
DA378_RS11470	COG1335	isochorismatase
DA378_RS11475	COG3858	chitin binding
DA378_RS11475	COG1388	LysM domain
DA378_RS11480	COG1428	Deoxynucleoside kinase
DA378_RS11485	COG1428	Deoxynucleoside kinase
DA378_RS11495	COG1929	Belongs to the glycerate kinase type-1 family
DA378_RS11515	COG1686	Belongs to the peptidase S11 family
DA378_RS11520	COG0516	GMP reductase activity
DA378_RS11520	COG0517	IMP dehydrogenase activity
DA378_RS11555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA378_RS11560	COG0187	DNA topoisomerase II activity
DA378_RS11575	COG2501	S4 domain
DA378_RS11580	COG0592	DNA-directed DNA polymerase activity
DA378_RS11600	COG0706	membrane insertase activity
DA378_RS11605	COG1847	R3H domain protein
DA378_RS11630	COG1192	Involved in chromosome partitioning
DA378_RS11635	COG1475	DNA binding
DA378_RS11650	COG3949	Membrane
DA378_RS11655	COG4481	Protein conserved in bacteria
DA378_RS11660	COG0243	molybdopterin cofactor binding
DA378_RS11665	COG0012	GTP binding
DA378_RS11675	COG0629	single-stranded DNA binding
DA378_RS11685	COG2169	Transcriptional regulator
DA378_RS11690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA378_RS11695	COG0708	Exodeoxyribonuclease III
DA378_RS11700	COG1609	Transcriptional regulator
DA378_RS11705	COG0346	lactoylglutathione lyase activity
DA378_RS11710	COG2814	Major facilitator Superfamily
DA378_RS11710	COG0477	Major facilitator Superfamily
DA378_RS11715	COG1266	CAAX protease self-immunity
DA378_RS11720	COG1331	Highly conserved protein containing a thioredoxin domain
DA378_RS11735	COG1959	2 iron, 2 sulfur cluster binding
DA378_RS11745	COG1090	epimerase
DA378_RS11750	COG1331	Highly conserved protein containing a thioredoxin domain
DA378_RS11755	COG0697	spore germination
DA378_RS11760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA378_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS11775	COG0583	DNA-binding transcription factor activity
DA378_RS11800	COG1846	Transcriptional regulator
DA378_RS11805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS11810	COG1846	Transcriptional regulator
DA378_RS11815	COG0778	Nitroreductase
DA378_RS11825	COG2211	Major facilitator Superfamily
DA378_RS11830	COG2318	DinB family
DA378_RS11835	COG1802	Transcriptional regulator
DA378_RS11840	COG1621	beta-fructofuranosidase activity
DA378_RS11845	COG1621	beta-fructofuranosidase activity
DA378_RS11850	COG0697	spore germination
DA378_RS11860	COG1733	regulation of RNA biosynthetic process
DA378_RS11865	COG5577	PFAM Coat F domain
DA378_RS11875	COG4241	membrane
DA378_RS11880	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DA378_RS11900	COG0438	transferase activity, transferring glycosyl groups
DA378_RS11905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DA378_RS11915	COG0297	glycogen (starch) synthase activity
DA378_RS11925	COG3093	addiction module antidote protein HigA
DA378_RS11940	COG0305	Participates in initiation and elongation during chromosome replication
DA378_RS11945	COG0346	lactoylglutathione lyase activity
DA378_RS11980	COG0745	RESPONSE REGULATOR receiver
DA378_RS11985	COG5002	protein histidine kinase activity
DA378_RS11990	COG4863	YycH protein
DA378_RS11995	COG4853	Protein conserved in bacteria
DA378_RS12000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DA378_RS12005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA378_RS12015	COG5002	protein histidine kinase activity
DA378_RS12020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA378_RS12035	COG0488	(ABC) transporter
DA378_RS12045	COG3829	transcription factor binding
DA378_RS12050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA378_RS12055	COG0833	amino acid
DA378_RS12060	COG0010	Belongs to the arginase family
DA378_RS12065	COG0457	Tetratricopeptide repeat
DA378_RS12070	COG0456	acetyltransferase
DA378_RS12075	COG0667	Aldo Keto reductase
DA378_RS12080	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DA378_RS12140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DA378_RS12160	COG2080	2 iron, 2 sulfur cluster binding
DA378_RS12170	COG1113	amino acid transport
DA378_RS12175	COG3634	alkyl hydroperoxide reductase activity
DA378_RS12180	COG0450	alkyl hydroperoxide reductase
DA378_RS12190	COG1714	RDD family
DA378_RS12195	COG2814	Major facilitator Superfamily
DA378_RS12200	COG0640	Transcriptional regulator
DA378_RS12210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA378_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS12220	COG1309	transcriptional regulator
DA378_RS12230	COG3239	Fatty acid desaturase
DA378_RS12235	COG4585	Histidine kinase
DA378_RS12240	COG2197	response regulator
DA378_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS12255	COG2814	Major facilitator Superfamily
DA378_RS12260	COG0667	Aldo Keto reductase
DA378_RS12265	COG1349	DNA-binding transcription factor activity
DA378_RS12295	COG2814	Major facilitator Superfamily
DA378_RS12305	COG1082	Xylose isomerase domain protein TIM barrel
DA378_RS12320	COG0745	RESPONSE REGULATOR receiver
DA378_RS12325	COG2205	protein histidine kinase activity
DA378_RS12330	COG1136	(ABC) transporter
DA378_RS12335	COG0577	efflux transmembrane transporter activity
DA378_RS12340	COG5294	Protein conserved in bacteria
DA378_RS12345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA378_RS12375	COG0561	phosphatase activity
DA378_RS12380	COG2390	Transcriptional regulator
DA378_RS12390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA378_RS12395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DA378_RS12400	COG0833	amino acid
DA378_RS12405	COG0010	Belongs to the arginase family
DA378_RS12435	COG0494	nUDIX hydrolase
DA378_RS12445	COG0589	response to stress
DA378_RS12450	COG0697	spore germination
DA378_RS12525	COG0513	Belongs to the DEAD box helicase family
DA378_RS12530	COG2270	Major facilitator Superfamily
DA378_RS12540	COG2273	Hydrolase Family 16
DA378_RS12545	COG2851	Citrate transporter
DA378_RS12550	COG0753	catalase activity
DA378_RS12550	COG0693	protein deglycase activity
DA378_RS12565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA378_RS12570	COG0500	methyltransferase
DA378_RS12575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA378_RS12580	COG4894	glucomannan catabolic process
DA378_RS12590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA378_RS12600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS12605	COG2508	Transcriptional regulator
DA378_RS12610	COG3842	ATPase activity
DA378_RS12615	COG0726	polysaccharide deacetylase
DA378_RS12620	COG3493	citrate carrier protein
DA378_RS12625	COG1271	oxidase subunit
DA378_RS12630	COG1294	oxidase, subunit
DA378_RS12635	COG4988	ABC transporter
DA378_RS12640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DA378_RS12645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA378_RS12650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA378_RS12655	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DA378_RS12660	COG0753	catalase activity
DA378_RS12670	COG1482	cell wall glycoprotein biosynthetic process
DA378_RS12675	COG1940	carbohydrate kinase activity
DA378_RS12680	COG2723	6-phospho-beta-galactosidase activity
DA378_RS12685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS12690	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA378_RS12695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS12700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA378_RS12705	COG0640	Transcriptional regulator
DA378_RS12715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS12735	COG3711	transcriptional antiterminator
DA378_RS12735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS12740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS12745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS12750	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA378_RS12755	COG1486	melibiose metabolic process
DA378_RS12760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA378_RS12765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DA378_RS12775	COG1696	Membrane protein involved in D-alanine export
DA378_RS12800	COG1575	Belongs to the MenA family. Type 1 subfamily
DA378_RS12805	COG2357	RelA SpoT domain protein
DA378_RS12810	COG1442	glycosyl transferase family 8
DA378_RS12815	COG1404	Belongs to the peptidase S8 family
DA378_RS12820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA378_RS12825	COG0346	lactoylglutathione lyase activity
DA378_RS12830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA378_RS12835	COG0789	Transcriptional regulator
DA378_RS12840	COG4895	conserved protein (DUF2196)
DA378_RS12845	COG1346	cytolysis
DA378_RS12855	COG0583	DNA-binding transcription factor activity
DA378_RS12875	COG2822	iron ion transport
DA378_RS12880	COG2837	iron assimilation
DA378_RS12885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DA378_RS12905	COG1309	transcriptional regulator
DA378_RS12910	COG2246	polysaccharide biosynthetic process
DA378_RS12915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA378_RS12915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA378_RS12920	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DA378_RS12925	COG2261	transglycosylase associated protein
DA378_RS12930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA378_RS12935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA378_RS12955	COG0454	-acetyltransferase
DA378_RS12960	COG0772	Belongs to the SEDS family
DA378_RS12965	COG0778	Nitroreductase
DA378_RS12970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS12975	COG1404	Belongs to the peptidase S8 family
DA378_RS12985	COG3711	transcriptional antiterminator
DA378_RS12995	COG1621	beta-fructofuranosidase activity
DA378_RS13005	COG0351	phosphomethylpyrimidine kinase
DA378_RS13010	COG1695	Transcriptional regulator
DA378_RS13025	COG1216	Glycosyl transferase, family 2
DA378_RS13040	COG2233	PERMEase
DA378_RS13045	COG2363	Small membrane protein
DA378_RS13055	COG0463	Glycosyl transferase, family 2
DA378_RS13060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA378_RS13065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA378_RS13070	COG0456	acetyltransferase
DA378_RS13075	COG2089	acid synthase
DA378_RS13080	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DA378_RS13085	COG3980	spore coat polysaccharide biosynthesis protein
DA378_RS13090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DA378_RS13095	COG1088	dTDP-glucose 4,6-dehydratase activity
DA378_RS13100	COG1091	dTDP-4-dehydrorhamnose reductase activity
DA378_RS13105	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DA378_RS13115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA378_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS13125	COG4187	Peptidase family M20/M25/M40
DA378_RS13130	COG0833	amino acid
DA378_RS13135	COG2814	Major facilitator Superfamily
DA378_RS13140	COG2814	Major facilitator Superfamily
DA378_RS13170	COG0436	Aminotransferase
DA378_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS13185	COG0280	phosphate acetyltransferase
DA378_RS13190	COG2855	membrane
DA378_RS13195	COG0583	DNA-binding transcription factor activity
DA378_RS13225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DA378_RS13230	COG1131	(ABC) transporter
DA378_RS13240	COG1695	Transcriptional regulator
DA378_RS13255	COG1078	dGTPase activity
DA378_RS13260	COG3465	dGTPase activity
DA378_RS13265	COG0531	amino acid
DA378_RS13275	COG1846	Transcriptional regulator
DA378_RS13280	COG1942	4-Oxalocrotonate Tautomerase
DA378_RS13285	COG1994	Peptidase M50
DA378_RS13300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA378_RS13305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA378_RS13310	COG0010	Belongs to the arginase family
DA378_RS13355	COG0457	Tetratricopeptide repeat
DA378_RS13360	COG4506	Protein conserved in bacteria
DA378_RS13370	COG2223	nitrite transmembrane transporter activity
DA378_RS13375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA378_RS13385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA378_RS13395	COG1140	nitrate reductase beta subunit
DA378_RS13400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DA378_RS13405	COG2181	nitrate reductase activity
DA378_RS13415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA378_RS13420	COG1132	(ABC) transporter
DA378_RS13435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA378_RS13440	COG2181	nitrate reductase activity
DA378_RS13440	COG0247	lactate metabolic process
DA378_RS13455	COG4821	SIS domain
DA378_RS13460	COG2204	response regulator
DA378_RS13465	COG0191	fructose-bisphosphate aldolase activity
DA378_RS13475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA378_RS13480	COG1494	fructose-1,6-bisphosphatase
DA378_RS13485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA378_RS13500	COG0281	malic enzyme
DA378_RS13505	COG0679	Auxin Efflux Carrier
DA378_RS13510	COG0789	Transcriptional regulator
DA378_RS13515	COG0346	lactoylglutathione lyase activity
DA378_RS13520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA378_RS13525	COG2890	protein-(glutamine-N5) methyltransferase activity
DA378_RS13545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA378_RS13550	COG0009	L-threonylcarbamoyladenylate synthase
DA378_RS13560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA378_RS13565	COG0698	ribose 5-phosphate isomerase
DA378_RS13635	COG4836	Membrane
DA378_RS13645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA378_RS13650	COG2385	sporulation resulting in formation of a cellular spore
DA378_RS13655	COG2304	oxidoreductase activity
DA378_RS13660	COG2304	oxidoreductase activity
DA378_RS13665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA378_RS13675	COG0457	Tetratricopeptide repeat
DA378_RS13680	COG1994	Peptidase M50
DA378_RS13685	COG3237	CsbD-like
DA378_RS13690	COG0831	urea catabolic process
DA378_RS13705	COG1959	2 iron, 2 sulfur cluster binding
DA378_RS13715	COG0726	polysaccharide deacetylase
DA378_RS13725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA378_RS13740	COG1247	-acetyltransferase
DA378_RS13745	COG0739	heme binding
DA378_RS13755	COG0671	phosphoesterase, PA-phosphatase related
DA378_RS13760	COG0772	Belongs to the SEDS family
DA378_RS13765	COG0347	Belongs to the P(II) protein family
DA378_RS13770	COG0004	ammonium transporteR
DA378_RS13775	COG1335	isochorismatase
DA378_RS13780	COG0477	Major facilitator Superfamily
DA378_RS13785	COG1953	Uracil, thiamine, allantoin
DA378_RS13790	COG2814	Major facilitator Superfamily
DA378_RS13795	COG1846	Transcriptional regulator
DA378_RS13805	COG1077	Cell shape determining protein MreB Mrl
DA378_RS13810	COG4786	Flagellar basal body rod
DA378_RS13815	COG4786	Flagellar basal body rod
DA378_RS13820	COG0457	Tetratricopeptide repeat
DA378_RS13845	COG0629	single-stranded DNA binding
DA378_RS13850	COG1349	DNA-binding transcription factor activity
DA378_RS13855	COG0561	phosphatase activity
DA378_RS13860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA378_RS13865	COG4715	Zinc finger, swim domain protein
DA378_RS13880	COG3944	biosynthesis protein
DA378_RS13885	COG0489	protein tyrosine kinase activity
DA378_RS13890	COG4464	protein tyrosine phosphatase activity
DA378_RS13895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA378_RS13900	COG3878	Protein conserved in bacteria
DA378_RS13915	COG5444	nuclease activity
DA378_RS13970	COG0583	DNA-binding transcription factor activity
DA378_RS13975	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA378_RS13985	COG2059	Chromate
DA378_RS13990	COG2059	Chromate
DA378_RS13995	COG1522	sequence-specific DNA binding
DA378_RS14000	COG0405	Gamma-glutamyltransferase
DA378_RS14010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA378_RS14020	COG5337	Spore coat protein CotH
DA378_RS14035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA378_RS14040	COG0583	DNA-binding transcription factor activity
DA378_RS14045	COG0028	Belongs to the TPP enzyme family
DA378_RS14050	COG3527	Alpha-acetolactate decarboxylase
DA378_RS14055	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA378_RS14060	COG3103	Sh3 type 3 domain protein
DA378_RS14065	COG1879	ABC-type sugar transport system periplasmic component
DA378_RS14070	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA378_RS14075	COG1129	ABC transporter
DA378_RS14085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA378_RS14090	COG1609	Transcriptional regulator
DA378_RS14100	COG0814	amino acid
DA378_RS14105	COG0697	spore germination
DA378_RS14115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DA378_RS14125	COG2843	Capsule synthesis protein
DA378_RS14135	COG0791	NLP P60 protein
DA378_RS14140	COG2433	Pfam Transposase IS66
DA378_RS14145	COG0561	phosphatase activity
DA378_RS14150	COG1316	TRANSCRIPTIONal
DA378_RS14155	COG2814	Major facilitator Superfamily
DA378_RS14160	COG1215	transferase activity, transferring glycosyl groups
DA378_RS14175	COG0697	spore germination
DA378_RS14180	COG1482	cell wall glycoprotein biosynthetic process
DA378_RS14185	COG4193	domain, Protein
DA378_RS14190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA378_RS14195	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DA378_RS14200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DA378_RS14210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA378_RS14215	COG1682	transport, permease protein
DA378_RS14220	COG1134	teichoic acid transport
DA378_RS14225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA378_RS14230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DA378_RS14235	COG1316	TRANSCRIPTIONal
DA378_RS14245	COG2385	sporulation resulting in formation of a cellular spore
DA378_RS14245	COG2247	cell wall binding repeat
DA378_RS14250	COG2247	cell wall binding repeat
DA378_RS14250	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS14260	COG2244	polysaccharide biosynthetic process
DA378_RS14265	COG0297	glycogen (starch) synthase activity
DA378_RS14265	COG0438	transferase activity, transferring glycosyl groups
DA378_RS14270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA378_RS14275	COG3307	-O-antigen
DA378_RS14280	COG3206	protein involved in exopolysaccharide biosynthesis
DA378_RS14285	COG1215	transferase activity, transferring glycosyl groups
DA378_RS14290	COG0438	transferase activity, transferring glycosyl groups
DA378_RS14295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA378_RS14300	COG1316	TRANSCRIPTIONal
DA378_RS14305	COG1739	Uncharacterized protein family UPF0029
DA378_RS14310	COG4585	Histidine kinase
DA378_RS14315	COG2197	response regulator
DA378_RS14320	COG1307	EDD domain protein, DegV family
DA378_RS14325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DA378_RS14335	COG1040	competence protein
DA378_RS14345	COG2747	anti-sigma28 factor FlgM
DA378_RS14350	COG3418	PFAM FlgN family protein
DA378_RS14355	COG4786	Flagellar basal body rod
DA378_RS14355	COG1256	bacterial-type flagellum assembly
DA378_RS14360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA378_RS14380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA378_RS14385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DA378_RS14390	COG1516	flagellar protein fliS
DA378_RS14405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA378_RS14420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS14425	COG2010	Cytochrome c
DA378_RS14430	COG2884	Cell division ATP-binding protein ftsE
DA378_RS14435	COG2177	Part of the ABC transporter FtsEX involved in
DA378_RS14440	COG3420	alginic acid biosynthetic process
DA378_RS14445	COG0793	Belongs to the peptidase S41A family
DA378_RS14445	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS14455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA378_RS14485	COG2814	Major facilitator Superfamily
DA378_RS14490	COG1309	transcriptional regulator
DA378_RS14495	COG3848	Pyruvate phosphate dikinase
DA378_RS14495	COG0574	Belongs to the PEP-utilizing enzyme family
DA378_RS14500	COG4897	Protein conserved in bacteria
DA378_RS14510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA378_RS14525	COG3595	metallopeptidase activity
DA378_RS14530	COG1983	PspC domain protein
DA378_RS14535	COG1950	PFAM Membrane protein of
DA378_RS14540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DA378_RS14545	COG1309	transcriptional regulator
DA378_RS14550	COG2188	Transcriptional regulator
DA378_RS14560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA378_RS14580	COG0110	maltose O-acetyltransferase activity
DA378_RS14585	COG4990	cell redox homeostasis
DA378_RS14600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DA378_RS14625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DA378_RS14625	COG0140	phosphoribosyl-ATP diphosphatase activity
DA378_RS14630	COG1132	(ABC) transporter
DA378_RS14640	COG0745	RESPONSE REGULATOR receiver
DA378_RS14645	COG5002	protein histidine kinase activity
DA378_RS14650	COG0457	Tetratricopeptide repeat
DA378_RS14655	COG0791	NLP P60 protein
DA378_RS14655	COG3883	PFAM NLP P60 protein
DA378_RS14660	COG0492	ferredoxin-NADP+ reductase activity
DA378_RS14665	COG1051	belongs to the nudix hydrolase family
DA378_RS14675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA378_RS14685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS14690	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DA378_RS14695	COG4290	ribonuclease
DA378_RS14700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA378_RS14710	COG0288	reversible hydration of carbon dioxide
DA378_RS14715	COG0659	secondary active sulfate transmembrane transporter activity
DA378_RS14720	COG1694	Mazg nucleotide pyrophosphohydrolase
DA378_RS14725	COG1611	Belongs to the LOG family
DA378_RS14730	COG2814	Major facilitator Superfamily
DA378_RS14730	COG0477	Major facilitator Superfamily
DA378_RS14735	COG2828	Protein conserved in bacteria
DA378_RS14740	COG0583	DNA-binding transcription factor activity
DA378_RS14750	COG1609	Transcriptional regulator
DA378_RS14755	COG2223	nitrite transmembrane transporter activity
DA378_RS14810	COG3479	Phenolic acid decarboxylase
DA378_RS14815	COG0456	acetyltransferase
DA378_RS14820	COG2364	Membrane
DA378_RS14825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA378_RS14835	COG2272	Belongs to the type-B carboxylesterase lipase family
DA378_RS14840	COG1396	sequence-specific DNA binding
DA378_RS14845	COG3944	biosynthesis protein
DA378_RS14850	COG0489	protein tyrosine kinase activity
DA378_RS14855	COG1086	Polysaccharide biosynthesis protein
DA378_RS14860	COG0438	transferase activity, transferring glycosyl groups
DA378_RS14865	COG1215	transferase activity, transferring glycosyl groups
DA378_RS14870	COG0438	transferase activity, transferring glycosyl groups
DA378_RS14880	COG1216	Glycosyl transferase, family 2
DA378_RS14885	COG5039	Polysaccharide pyruvyl transferase
DA378_RS14890	COG1216	Glycosyl transferase, family 2
DA378_RS14895	COG2244	polysaccharide biosynthetic process
DA378_RS14900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA378_RS14905	COG0110	maltose O-acetyltransferase activity
DA378_RS14910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA378_RS14915	COG5039	Polysaccharide pyruvyl transferase
DA378_RS14925	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DA378_RS14930	COG1620	l-lactate permease
DA378_RS14935	COG2186	Transcriptional regulator
DA378_RS14940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA378_RS14965	COG1070	Carbohydrate kinase
DA378_RS14970	COG1737	Transcriptional regulator
DA378_RS14975	COG1113	amino acid transport
DA378_RS14980	COG0697	spore germination
DA378_RS14985	COG0583	DNA-binding transcription factor activity
DA378_RS14995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS15000	COG1609	Transcriptional regulator
DA378_RS15005	COG2814	Major facilitator Superfamily
DA378_RS15010	COG2390	Transcriptional regulator
DA378_RS15015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA378_RS15025	COG0126	phosphoglycerate kinase activity
DA378_RS15045	COG2234	aminopeptidase activity
DA378_RS15055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA378_RS15060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA378_RS15065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA378_RS15080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA378_RS15095	COG0456	acetyltransferase
DA378_RS15100	COG4640	response to antibiotic
DA378_RS15105	COG3064	Membrane
DA378_RS15110	COG2095	MarC family integral membrane protein
DA378_RS15115	COG1510	regulation of RNA biosynthetic process
DA378_RS15120	COG0517	IMP dehydrogenase activity
DA378_RS15120	COG1125	glycine betaine transport
DA378_RS15125	COG1174	glycine betaine transport
DA378_RS15130	COG1732	Glycine betaine
DA378_RS15135	COG1174	glycine betaine transport
DA378_RS15140	COG1510	regulation of RNA biosynthetic process
DA378_RS15145	COG1125	glycine betaine transport
DA378_RS15145	COG0517	IMP dehydrogenase activity
DA378_RS15150	COG1174	glycine betaine transport
DA378_RS15155	COG1732	Glycine betaine
DA378_RS15160	COG1174	glycine betaine transport
DA378_RS15165	COG1131	(ABC) transporter
DA378_RS15190	COG1733	regulation of RNA biosynthetic process
DA378_RS15195	COG1396	sequence-specific DNA binding
DA378_RS15200	COG1396	sequence-specific DNA binding
DA378_RS15205	COG1476	TRANSCRIPTIONal
DA378_RS15210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA378_RS15215	COG1647	Serine aminopeptidase, S33
DA378_RS15220	COG0557	exoribonuclease II activity
DA378_RS15245	COG2732	(Barnase) inhibitor
DA378_RS15250	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS15255	COG0583	DNA-binding transcription factor activity
DA378_RS15260	COG0454	-acetyltransferase
DA378_RS15265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS15270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS15275	COG0765	amino acid transport
DA378_RS15280	COG0765	amino acid transport
DA378_RS15285	COG1126	abc transporter atp-binding protein
DA378_RS15290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS15295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA378_RS15300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA378_RS15310	COG0673	inositol 2-dehydrogenase activity
DA378_RS15315	COG1937	Protein conserved in bacteria
DA378_RS15320	COG2608	mercury ion transmembrane transporter activity
DA378_RS15325	COG2217	Heavy metal translocating P-type atpase
DA378_RS15330	COG2217	Heavy metal translocating P-type atpase
DA378_RS15335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA378_RS15340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DA378_RS15350	COG2860	membrane
DA378_RS15355	COG3973	AAA domain
DA378_RS15360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA378_RS15385	COG0656	L-ascorbic acid biosynthetic process
DA378_RS15390	COG0842	Transport permease protein
DA378_RS15400	COG1131	(ABC) transporter
DA378_RS15405	COG3850	Histidine kinase
DA378_RS15410	COG2197	response regulator
DA378_RS15415	COG4149	molybdate abc transporter
DA378_RS15420	COG0725	ABC transporter, periplasmic molybdate-binding protein
DA378_RS15425	COG1910	domain protein
DA378_RS15430	COG1368	sulfuric ester hydrolase activity
DA378_RS15435	COG1988	membrane-bound metal-dependent
DA378_RS15450	COG0531	amino acid
DA378_RS15455	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DA378_RS15460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA378_RS15465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS15470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS15475	COG1120	ATPase activity
DA378_RS15485	COG2140	Oxalate decarboxylase
DA378_RS15495	COG1191	sigma factor activity
DA378_RS15505	COG0745	RESPONSE REGULATOR receiver
DA378_RS15510	COG2205	protein histidine kinase activity
DA378_RS15515	COG3386	PFAM SMP-30 Gluconolaconase
DA378_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS15525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA378_RS15530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA378_RS15535	COG1120	ATPase activity
DA378_RS15540	COG2096	Adenosyltransferase
DA378_RS15545	COG2814	Major facilitator Superfamily
DA378_RS15550	COG4758	membrane
DA378_RS15555	COG1842	Phage shock protein A
DA378_RS15560	COG3595	metallopeptidase activity
DA378_RS15565	COG4758	membrane
DA378_RS15570	COG4585	Histidine kinase
DA378_RS15575	COG2197	response regulator
DA378_RS15585	COG0814	amino acid
DA378_RS15590	COG0697	spore germination
DA378_RS15600	COG0114	fumarate hydratase activity
DA378_RS15605	COG1309	transcriptional regulator
DA378_RS15615	COG2205	protein histidine kinase activity
DA378_RS15615	COG2770	Histidine kinase
DA378_RS15620	COG0745	RESPONSE REGULATOR receiver
DA378_RS15625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA378_RS15630	COG0783	Belongs to the Dps family
DA378_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS15650	COG1120	ATPase activity
DA378_RS15670	COG0583	DNA-binding transcription factor activity
DA378_RS15675	COG0477	Major facilitator Superfamily
DA378_RS15680	COG1846	Transcriptional regulator
DA378_RS15685	COG5577	PFAM Coat F domain
DA378_RS15705	COG1024	Enoyl-CoA hydratase
DA378_RS15705	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA378_RS15710	COG0183	Belongs to the thiolase family
DA378_RS15715	COG1960	acyl-CoA dehydrogenase activity
DA378_RS15720	COG1393	Belongs to the ArsC family
DA378_RS15735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DA378_RS15740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS15750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA378_RS15755	COG2011	ABC-type metal ion transport system permease component
DA378_RS15760	COG1464	Belongs to the NlpA lipoprotein family
DA378_RS15765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA378_RS15775	COG0396	ATPase activity
DA378_RS15780	COG0719	Fe-S assembly protein
DA378_RS15785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA378_RS15790	COG0822	iron-sulfur transferase activity
DA378_RS15795	COG0719	Fe-S assembly protein
DA378_RS15800	COG3409	Peptidoglycan-binding domain 1 protein
DA378_RS15810	COG2226	methyltransferase
DA378_RS15815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA378_RS15820	COG0322	excinuclease ABC activity
DA378_RS15835	COG0789	Transcriptional regulator
DA378_RS15840	COG2222	sugar isomerase
DA378_RS15845	COG1653	transport
DA378_RS15850	COG1175	transmembrane transport
DA378_RS15855	COG0395	ABC-type sugar transport system, permease component
DA378_RS15860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA378_RS15865	COG2188	Transcriptional regulator
DA378_RS15870	COG3842	ATPase activity
DA378_RS15875	COG2356	endonuclease I
DA378_RS15880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA378_RS15885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DA378_RS15890	COG2814	Major facilitator Superfamily
DA378_RS15900	COG2508	Transcriptional regulator
DA378_RS15920	COG0730	response to heat
DA378_RS15925	COG0737	Belongs to the 5'-nucleotidase family
DA378_RS15935	COG0739	heme binding
DA378_RS15950	COG4470	Protein conserved in bacteria
DA378_RS15955	COG2445	Protein of unknown function DUF86
DA378_RS15960	COG0647	UMP catabolic process
DA378_RS15965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DA378_RS15970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA378_RS15975	COG0460	homoserine dehydrogenase
DA378_RS15980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DA378_RS15990	COG4946	Tricorn protease homolog
DA378_RS15990	COG0823	Involved in the tonB-independent uptake of proteins
DA378_RS15990	COG1506	peptidase
DA378_RS15995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DA378_RS16000	COG4837	Protein of unknown function (DUF1462)
DA378_RS16005	COG1252	NADH dehydrogenase
DA378_RS16015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA378_RS16025	COG0316	Belongs to the HesB IscA family
DA378_RS16030	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DA378_RS16055	COG1131	(ABC) transporter
DA378_RS16085	COG1252	NADH dehydrogenase
DA378_RS16100	COG3584	3D domain protein
DA378_RS16105	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DA378_RS16115	COG2056	Na+-H+ antiporter family
DA378_RS16120	COG1268	BioY protein
DA378_RS16125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA378_RS16130	COG2819	hydrolase of the alpha beta superfamily
DA378_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS16140	COG1169	isochorismate synthase
DA378_RS16145	COG1021	2,3-dihydroxybenzoate-AMP ligase
DA378_RS16150	COG1535	isochorismatase
DA378_RS16150	COG3433	isochorismatase activity
DA378_RS16155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA378_RS16160	COG3251	PFAM MbtH domain protein
DA378_RS16165	COG5634	Uncharacterized conserved protein (DUF2278)
DA378_RS16170	COG0686	Belongs to the AlaDH PNT family
DA378_RS16175	COG2508	Transcriptional regulator
DA378_RS16175	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DA378_RS16180	COG4842	Belongs to the WXG100 family
DA378_RS16185	COG5417	Belongs to the EsaB family
DA378_RS16190	COG4499	WXG100 protein secretion system (Wss), protein YukC
DA378_RS16195	COG1674	ftsk spoiiie
DA378_RS16195	COG0433	COG0433 Predicted ATPase
DA378_RS16200	COG1511	domain protein
DA378_RS16210	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS16215	COG1418	mRNA catabolic process
DA378_RS16225	COG0628	permease
DA378_RS16240	COG5506	Protein of unknown function (DUF1694)
DA378_RS16245	COG1335	isochorismatase
DA378_RS16250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DA378_RS16255	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DA378_RS16270	COG0142	geranyltranstransferase activity
DA378_RS16280	COG4585	Histidine kinase
DA378_RS16285	COG2197	response regulator
DA378_RS16290	COG2050	protein possibly involved in aromatic compounds catabolism
DA378_RS16295	COG1320	monovalent cation:proton antiporter activity
DA378_RS16300	COG2212	antiporter activity
DA378_RS16305	COG1863	multisubunit Na H antiporter MnhE subunit
DA378_RS16310	COG0651	ATP synthesis coupled electron transport
DA378_RS16315	COG1006	Multisubunit Na H antiporter MnhC subunit
DA378_RS16320	COG2111	Na H antiporter
DA378_RS16325	COG2111	Na H antiporter
DA378_RS16325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA378_RS16335	COG1079	Belongs to the binding-protein-dependent transport system permease family
DA378_RS16340	COG4603	Belongs to the binding-protein-dependent transport system permease family
DA378_RS16345	COG3845	ABC transporter
DA378_RS16350	COG1744	ABC transporter substrate-binding protein PnrA-like
DA378_RS16355	COG4565	transcriptional regulatory protein
DA378_RS16360	COG3290	protein histidine kinase activity
DA378_RS16370	COG3011	Protein conserved in bacteria
DA378_RS16375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA378_RS16380	COG2814	Major facilitator Superfamily
DA378_RS16385	COG5018	Exonuclease
DA378_RS16395	COG2205	protein histidine kinase activity
DA378_RS16400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DA378_RS16410	COG2267	carboxylic ester hydrolase activity
DA378_RS16415	COG1522	sequence-specific DNA binding
DA378_RS16420	COG0436	Aminotransferase
DA378_RS16425	COG1098	S1 RNA binding domain
DA378_RS16430	COG2155	Conserved Protein
DA378_RS16435	COG1979	alcohol dehydrogenase
DA378_RS16440	COG1979	alcohol dehydrogenase
DA378_RS16450	COG1335	isochorismatase
DA378_RS16480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA378_RS16495	COG2738	Putative neutral zinc metallopeptidase
DA378_RS16500	COG1253	flavin adenine dinucleotide binding
DA378_RS16505	COG0366	Alpha amylase catalytic
DA378_RS16510	COG0432	Pfam Uncharacterised protein family UPF0047
DA378_RS16515	COG2070	2-Nitropropane dioxygenase
DA378_RS16530	COG0840	transmembrane signaling receptor activity
DA378_RS16535	COG0840	transmembrane signaling receptor activity
DA378_RS16540	COG0840	transmembrane signaling receptor activity
DA378_RS16545	COG0840	transmembrane signaling receptor activity
DA378_RS16550	COG0693	protein deglycase activity
DA378_RS16555	COG0673	inositol 2-dehydrogenase activity
DA378_RS16560	COG0628	permease
DA378_RS16585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA378_RS16585	COG1017	nitric oxide dioxygenase activity
DA378_RS16590	COG1705	Flagellar rod assembly protein muramidase FlgJ
DA378_RS16595	COG0569	domain protein
DA378_RS16605	COG1510	regulation of RNA biosynthetic process
DA378_RS16610	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS16615	COG1454	alcohol dehydrogenase
DA378_RS16625	COG2318	DinB family
DA378_RS16630	COG1585	Membrane protein implicated in regulation of membrane protease activity
DA378_RS16635	COG2268	Band 7 protein
DA378_RS16640	COG3859	Proton-coupled thiamine transporter YuaJ
DA378_RS16765	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DA378_RS16770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA378_RS16775	COG1169	isochorismate synthase
DA378_RS16785	COG0596	Alpha beta hydrolase
DA378_RS16790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DA378_RS16800	COG4948	Mandelate Racemase Muconate Lactonizing
DA378_RS16815	COG1294	oxidase, subunit
DA378_RS16820	COG1271	oxidase subunit
DA378_RS16830	COG0288	reversible hydration of carbon dioxide
DA378_RS16855	COG0783	Belongs to the Dps family
DA378_RS16860	COG4824	toxin secretion phage lysis holin
DA378_RS16865	COG0494	nUDIX hydrolase
DA378_RS16870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA378_RS16875	COG1116	anion transmembrane transporter activity
DA378_RS16880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA378_RS16885	COG1506	peptidase
DA378_RS16905	COG0367	asparagine synthase
DA378_RS16910	COG1113	amino acid transport
DA378_RS16915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA378_RS16920	COG2267	carboxylic ester hydrolase activity
DA378_RS16930	COG0584	glycerophosphoryl diester phosphodiesterase
DA378_RS16940	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DA378_RS16945	COG1242	4 iron, 4 sulfur cluster binding
DA378_RS16955	COG1725	Transcriptional regulator
DA378_RS16960	COG1131	(ABC) transporter
DA378_RS16980	COG1136	(ABC) transporter
DA378_RS16985	COG0577	efflux transmembrane transporter activity
DA378_RS16990	COG0745	RESPONSE REGULATOR receiver
DA378_RS16995	COG2205	protein histidine kinase activity
DA378_RS17000	COG1136	(ABC) transporter
DA378_RS17005	COG0577	efflux transmembrane transporter activity
DA378_RS17010	COG5522	Integral membrane protein (intg_mem_TP0381)
DA378_RS17015	COG2814	Major facilitator Superfamily
DA378_RS17020	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS17020	COG2202	Pas domain
DA378_RS17035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA378_RS17045	COG1486	melibiose metabolic process
DA378_RS17050	COG0395	ABC-type sugar transport system, permease component
DA378_RS17055	COG1175	transmembrane transport
DA378_RS17060	COG1653	transport
DA378_RS17065	COG1609	Transcriptional regulator
DA378_RS17075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA378_RS17080	COG2081	HI0933 family
DA378_RS17085	COG2244	polysaccharide biosynthetic process
DA378_RS17090	COG1187	pseudouridine synthase activity
DA378_RS17095	COG1349	DNA-binding transcription factor activity
DA378_RS17100	COG1131	(ABC) transporter
DA378_RS17105	COG4473	ABC transporter
DA378_RS17110	COG2252	PERMEase
DA378_RS17115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA378_RS17120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA378_RS17125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DA378_RS17135	COG1597	lipid kinase activity
DA378_RS17140	COG0510	thiamine kinase activity
DA378_RS17155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS17160	COG0281	malic enzyme
DA378_RS17165	COG5584	Small secreted protein
DA378_RS17170	COG1363	Peptidase, m42
DA378_RS17180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA378_RS17190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA378_RS17195	COG1674	ftsk spoiiie
DA378_RS17205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DA378_RS17210	COG4980	gas vesicle protein
DA378_RS17215	COG3118	belongs to the thioredoxin family
DA378_RS17220	COG1605	Chorismate mutase
DA378_RS17220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DA378_RS17225	COG1609	Transcriptional regulator
DA378_RS17230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA378_RS17235	COG1360	Flagellar Motor Protein
DA378_RS17240	COG0123	including yeast histone deacetylase and acetoin utilization protein
DA378_RS17245	COG0517	IMP dehydrogenase activity
DA378_RS17250	COG0454	-acetyltransferase
DA378_RS17255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA378_RS17280	COG1378	Sugar-specific transcriptional regulator TrmB
DA378_RS17285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA378_RS17300	COG0693	protein deglycase activity
DA378_RS17310	COG1017	nitric oxide dioxygenase activity
DA378_RS17310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA378_RS17320	COG4282	regulation of fungal-type cell wall biogenesis
DA378_RS17325	COG1012	belongs to the aldehyde dehydrogenase family
DA378_RS17345	COG1956	GAF domain-containing protein
DA378_RS17350	COG1309	transcriptional regulator
DA378_RS17355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA378_RS17365	COG1114	Component of the transport system for branched-chain amino acids
DA378_RS17370	COG1104	cysteine desulfurase activity
DA378_RS17385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA378_RS17390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DA378_RS17395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA378_RS17400	COG0616	signal peptide processing
DA378_RS17405	COG1714	RDD family
DA378_RS17415	COG3874	Sporulation protein YtfJ
DA378_RS17420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DA378_RS17425	COG0827	DNA restriction-modification system
DA378_RS17435	COG0521	Mo-molybdopterin cofactor biosynthetic process
DA378_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
DA378_RS17460	COG4109	DRTGG domain
DA378_RS17470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DA378_RS17490	COG0587	DNA-directed DNA polymerase activity
DA378_RS17495	COG0281	malic enzyme
DA378_RS17515	COG0469	pyruvate kinase activity
DA378_RS17520	COG3030	protein affecting phage T7 exclusion by the F plasmid
DA378_RS17525	COG0628	permease
DA378_RS17555	COG0372	Belongs to the citrate synthase family
DA378_RS17560	COG0538	isocitrate dehydrogenase activity
DA378_RS17570	COG0745	RESPONSE REGULATOR receiver
DA378_RS17575	COG5002	protein histidine kinase activity
DA378_RS17585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA378_RS17590	COG1971	Probably functions as a manganese efflux pump
DA378_RS17595	COG0237	dephospho-CoA kinase activity
DA378_RS17600	COG0656	L-ascorbic acid biosynthetic process
DA378_RS17605	COG2814	Major facilitator Superfamily
DA378_RS17610	COG1733	regulation of RNA biosynthetic process
DA378_RS17615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA378_RS17630	COG3611	Membrane attachment protein
DA378_RS17635	COG1484	DNA-dependent DNA replication
DA378_RS17640	COG0398	Pfam SNARE associated Golgi protein
DA378_RS17655	COG1011	Hydrolase
DA378_RS17660	COG3275	phosphorelay sensor kinase activity
DA378_RS17665	COG3279	Response regulator of the LytR AlgR family
DA378_RS17670	COG1380	Effector of murein hydrolase LrgA
DA378_RS17675	COG1346	cytolysis
DA378_RS17680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DA378_RS17690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DA378_RS17695	COG3326	Membrane
DA378_RS17705	COG1363	Peptidase, m42
DA378_RS17715	COG2160	L-arabinose isomerase activity
DA378_RS17720	COG1069	ribulokinase activity
DA378_RS17725	COG0235	Class ii aldolase
DA378_RS17730	COG0647	UMP catabolic process
DA378_RS17740	COG1653	transport
DA378_RS17745	COG1175	transmembrane transport
DA378_RS17750	COG0395	ABC-type sugar transport system, permease component
DA378_RS17755	COG3534	alpha-L-arabinofuranosidase
DA378_RS17760	COG1966	Carbon starvation protein
DA378_RS17765	COG0247	lactate metabolic process
DA378_RS17770	COG0277	FAD linked oxidase domain protein
DA378_RS17775	COG3835	regulator
DA378_RS17785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA378_RS17790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DA378_RS17795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA378_RS17795	COG0072	phenylalanine-tRNA ligase activity
DA378_RS17810	COG1286	toxin biosynthetic process
DA378_RS17815	COG1796	DNA polymerase
DA378_RS17815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA378_RS17825	COG3766	membrane
DA378_RS17835	COG0318	PFAM AMP-dependent synthetase and ligase
DA378_RS17840	COG1309	transcriptional regulator
DA378_RS17845	COG1024	Enoyl-CoA hydratase
DA378_RS17850	COG2086	electron transfer activity
DA378_RS17855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DA378_RS17860	COG3534	alpha-L-arabinofuranosidase
DA378_RS17865	COG3118	belongs to the thioredoxin family
DA378_RS17880	COG0527	aspartate kinase activity
DA378_RS17885	COG1719	4-vinyl reductase, 4VR
DA378_RS17890	COG2009	succinate dehydrogenase
DA378_RS17895	COG1053	succinate dehydrogenase
DA378_RS17900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA378_RS17905	COG0824	Thioesterase
DA378_RS17910	COG2197	response regulator
DA378_RS17915	COG1846	Transcriptional regulator
DA378_RS17925	COG5401	PFAM Sporulation and spore germination
DA378_RS17935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA378_RS17940	COG0622	Phosphoesterase
DA378_RS17970	COG0440	acetolactate synthase activity
DA378_RS17985	COG0473	3-isopropylmalate dehydrogenase activity
DA378_RS18000	COG1477	protein flavinylation
DA378_RS18000	COG0457	Tetratricopeptide repeat
DA378_RS18015	COG1067	ATP-dependent peptidase activity
DA378_RS18015	COG0470	DNA polymerase III
DA378_RS18020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA378_RS18040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA378_RS18050	COG1587	Uroporphyrinogen-III synthase
DA378_RS18055	COG0113	porphobilinogen synthase activity
DA378_RS18065	COG1388	LysM domain
DA378_RS18070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA378_RS18080	COG0525	valine-tRNA ligase activity
DA378_RS18085	COG0285	dihydrofolate synthase activity
DA378_RS18090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DA378_RS18110	COG1077	Cell shape determining protein MreB Mrl
DA378_RS18120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DA378_RS18130	COG2894	cell division
DA378_RS18135	COG0739	heme binding
DA378_RS18140	COG1994	Peptidase M50
DA378_RS18150	COG2868	ribosomal protein
DA378_RS18155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DA378_RS18160	COG3290	protein histidine kinase activity
DA378_RS18175	COG0077	Prephenate dehydratase
DA378_RS18180	COG1827	regulation of RNA biosynthetic process
DA378_RS18185	COG1104	cysteine desulfurase activity
DA378_RS18190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA378_RS18195	COG0157	Belongs to the NadC ModD family
DA378_RS18205	COG1388	LysM domain
DA378_RS18250	COG1862	Preprotein translocase
DA378_RS18260	COG2323	membrane
DA378_RS18265	COG2244	polysaccharide biosynthetic process
DA378_RS18275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA378_RS18275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA378_RS18280	COG0490	domain, Protein
DA378_RS18285	COG5416	Lipopolysaccharide assembly protein A domain
DA378_RS18290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DA378_RS18290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DA378_RS18300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA378_RS18310	COG4991	sh3 domain protein
DA378_RS18310	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS18310	COG3103	Sh3 type 3 domain protein
DA378_RS18330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA378_RS18335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA378_RS18340	COG1959	2 iron, 2 sulfur cluster binding
DA378_RS18345	COG1104	cysteine desulfurase activity
DA378_RS18355	COG0457	Tetratricopeptide repeat
DA378_RS18360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA378_RS18365	COG3881	PFAM PRC-barrel domain
DA378_RS18380	COG0765	amino acid transport
DA378_RS18385	COG0765	amino acid transport
DA378_RS18390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA378_RS18395	COG1126	abc transporter atp-binding protein
DA378_RS18400	COG0628	permease
DA378_RS18410	COG4472	Bacterial protein of unknown function (DUF965)
DA378_RS18425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA378_RS18430	COG4122	O-methyltransferase activity
DA378_RS18435	COG0826	peptidase U32
DA378_RS18440	COG0826	peptidase U32
DA378_RS18455	COG0768	penicillin binding
DA378_RS18480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA378_RS18485	COG0626	cystathionine gamma-synthase activity
DA378_RS18495	COG2427	Protein of unknown function (DUF1641)
DA378_RS18500	COG3383	formate dehydrogenase (NAD+) activity
DA378_RS18505	COG5609	conserved protein (DUF2294)
DA378_RS18510	COG2116	formate transmembrane transporter activity
DA378_RS18525	COG2226	methyltransferase
DA378_RS18530	COG1309	transcriptional regulator
DA378_RS18535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA378_RS18535	COG2124	cytochrome p450
DA378_RS18540	COG2814	Major facilitator Superfamily
DA378_RS18545	COG0583	DNA-binding transcription factor activity
DA378_RS18550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DA378_RS18560	COG3711	transcriptional antiterminator
DA378_RS18560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS18565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA378_RS18565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA378_RS18565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA378_RS18570	COG1482	cell wall glycoprotein biosynthetic process
DA378_RS18580	COG0561	phosphatase activity
DA378_RS18585	COG0561	phosphatase activity
DA378_RS18595	COG2318	DinB family
DA378_RS18600	COG0456	acetyltransferase
DA378_RS18610	COG2814	Major facilitator Superfamily
DA378_RS18620	COG0563	adenylate kinase activity
DA378_RS18630	COG3708	Transcriptional regulator
DA378_RS18630	COG2207	Transcriptional regulator
DA378_RS18645	COG4282	regulation of fungal-type cell wall biogenesis
DA378_RS18650	COG5444	nuclease activity
DA378_RS18685	COG0398	Pfam SNARE associated Golgi protein
DA378_RS18695	COG2755	lipolytic protein G-D-S-L family
DA378_RS18705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DA378_RS18710	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA378_RS18715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA378_RS18720	COG1534	Rna-binding protein
DA378_RS18730	COG1713	HD superfamily hydrolase involved in NAD metabolism
DA378_RS18735	COG0799	negative regulation of ribosome biogenesis
DA378_RS18740	COG2226	methyltransferase
DA378_RS18745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA378_RS18750	COG1555	photosystem II stabilization
DA378_RS18750	COG1596	polysaccharide export
DA378_RS18755	COG2131	deaminase
DA378_RS18760	COG0658	competence protein
DA378_RS18760	COG2333	competence protein COMEC
DA378_RS18770	COG1466	dna polymerase III delta subunit
DA378_RS18785	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS18800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA378_RS18830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DA378_RS18835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA378_RS18840	COG1283	sodium-dependent phosphate transmembrane transporter activity
DA378_RS18850	COG1610	YqeY-like protein
DA378_RS18855	COG1030	water channel activity
DA378_RS18860	COG4864	UPF0365 protein
DA378_RS18875	COG0561	phosphatase activity
DA378_RS18880	COG1702	phosphate starvation-inducible protein PhoH
DA378_RS18885	COG1480	7TM receptor with intracellular HD hydrolase
DA378_RS18895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA378_RS18900	COG0295	cytidine deaminase activity
DA378_RS18905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DA378_RS18925	COG0751	glycine-tRNA ligase activity
DA378_RS18930	COG0517	IMP dehydrogenase activity
DA378_RS18945	COG0358	DNA primase activity
DA378_RS18950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA378_RS18955	COG2010	Cytochrome c
DA378_RS18960	COG2384	SAM-dependent methyltransferase
DA378_RS18965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DA378_RS18980	COG0513	Belongs to the DEAD box helicase family
DA378_RS18995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA378_RS19000	COG0735	belongs to the Fur family
DA378_RS19005	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DA378_RS19010	COG4709	membrane
DA378_RS19020	COG1388	LysM domain
DA378_RS19025	COG5521	maltodextrose utilization protein MalA
DA378_RS19030	COG2839	Protein conserved in bacteria
DA378_RS19035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA378_RS19040	COG0477	Major facilitator Superfamily
DA378_RS19045	COG0768	penicillin binding
DA378_RS19055	COG0573	inorganic phosphate transmembrane transporter activity
DA378_RS19060	COG0581	inorganic phosphate transmembrane transporter activity
DA378_RS19065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA378_RS19070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA378_RS19075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA378_RS19090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DA378_RS19100	COG1757	Na H antiporter
DA378_RS19105	COG4483	Protein conserved in bacteria
DA378_RS19110	COG1940	carbohydrate kinase activity
DA378_RS19115	COG2866	Carboxypeptidase
DA378_RS19125	COG0011	TIGRFAM Protein of
DA378_RS19135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA378_RS19145	COG1393	Belongs to the ArsC family
DA378_RS19155	COG1366	Belongs to the anti-sigma-factor antagonist family
DA378_RS19160	COG1253	flavin adenine dinucleotide binding
DA378_RS19165	COG0598	Magnesium transport protein CorA
DA378_RS19170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA378_RS19175	COG1459	type II secretion system
DA378_RS19180	COG4537	Required for transformation and DNA binding
DA378_RS19185	COG4970	Tfp pilus assembly protein FimT
DA378_RS19220	COG0681	Belongs to the peptidase S26 family
DA378_RS19230	COG1396	sequence-specific DNA binding
DA378_RS19245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA378_RS19265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA378_RS19280	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA378_RS19290	COG3872	metal-dependent enzyme
DA378_RS19300	COG0006	proline dipeptidase activity
DA378_RS19315	COG3854	ATPases associated with a variety of cellular activities
DA378_RS19355	COG0511	ligase activity, forming carbon-carbon bonds
DA378_RS19360	COG0439	Biotin carboxylase
DA378_RS19365	COG1302	Protein conserved in bacteria
DA378_RS19380	COG1570	exodeoxyribonuclease VII activity
DA378_RS19390	COG0142	geranyltranstransferase activity
DA378_RS19400	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DA378_RS19410	COG0497	DNA recombination
DA378_RS19415	COG0750	zinc metalloprotease
DA378_RS19420	COG0745	RESPONSE REGULATOR receiver
DA378_RS19425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA378_RS19440	COG1902	pentaerythritol trinitrate reductase activity
DA378_RS19460	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA378_RS19465	COG0584	glycerophosphoryl diester phosphodiesterase
DA378_RS19470	COG0183	Belongs to the thiolase family
DA378_RS19475	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA378_RS19480	COG1960	acyl-CoA dehydrogenase activity
DA378_RS19485	COG0372	Belongs to the citrate synthase family
DA378_RS19490	COG2079	MmgE PrpD family protein
DA378_RS19495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate