locus-tag	class	description
H2N74_RS00010	COG0592	DNA-directed DNA polymerase activity
H2N74_RS00015	COG2501	S4 domain
H2N74_RS00030	COG0187	DNA topoisomerase II activity
H2N74_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2N74_RS00070	COG0516	GMP reductase activity
H2N74_RS00070	COG0517	IMP dehydrogenase activity
H2N74_RS00075	COG1686	Belongs to the peptidase S11 family
H2N74_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
H2N74_RS00105	COG1428	Deoxynucleoside kinase
H2N74_RS00110	COG1428	Deoxynucleoside kinase
H2N74_RS00115	COG3858	chitin binding
H2N74_RS00115	COG1388	LysM domain
H2N74_RS00120	COG1335	isochorismatase
H2N74_RS00125	COG0590	tRNA wobble adenosine to inosine editing
H2N74_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2N74_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H2N74_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H2N74_RS00195	COG3853	Toxic anion resistance protein (TelA)
H2N74_RS00200	COG1982	Orn Lys Arg decarboxylase major
H2N74_RS00210	COG3870	Protein conserved in bacteria
H2N74_RS00215	COG1728	Protein conserved in bacteria
H2N74_RS00220	COG0470	DNA polymerase III
H2N74_RS00225	COG1774	PSP1 C-terminal conserved region
H2N74_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H2N74_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H2N74_RS00250	COG2002	toxin-antitoxin pair type II binding
H2N74_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2N74_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2N74_RS00260	COG0084	hydrolase, TatD family'
H2N74_RS00265	COG3583	domain protein
H2N74_RS00265	COG3584	3D domain protein
H2N74_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H2N74_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2N74_RS00285	COG4466	Protein conserved in bacteria
H2N74_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2N74_RS00305	COG0251	oxidation-reduction process
H2N74_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2N74_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2N74_RS00345	COG2002	toxin-antitoxin pair type II binding
H2N74_RS00350	COG2244	polysaccharide biosynthetic process
H2N74_RS00355	COG3956	TIGRFAM MazG family protein
H2N74_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2N74_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2N74_RS00380	COG1098	S1 RNA binding domain
H2N74_RS00395	COG2208	phosphoserine phosphatase activity
H2N74_RS00400	COG2304	oxidoreductase activity
H2N74_RS00405	COG0515	serine threonine protein kinase
H2N74_RS00410	COG0037	tRNA processing
H2N74_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2N74_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2N74_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2N74_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2N74_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
H2N74_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2N74_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2N74_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2N74_RS00475	COG1396	sequence-specific DNA binding
H2N74_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2N74_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2N74_RS00565	COG4463	regulation of RNA biosynthetic process
H2N74_RS00570	COG3880	PFAM UvrB UvrC protein
H2N74_RS00580	COG0542	response to heat
H2N74_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H2N74_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H2N74_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
H2N74_RS00615	COG1045	serine acetyltransferase
H2N74_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H2N74_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2N74_RS00635	COG3688	RNA-binding protein containing a PIN domain
H2N74_RS00640	COG1595	DNA-templated transcription, initiation
H2N74_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2N74_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
H2N74_RS00680	COG2813	Specifically methylates the guanine in position
H2N74_RS00695	COG1358	cellular component organization or biogenesis
H2N74_RS00720	COG0596	Alpha beta hydrolase
H2N74_RS00830	COG0201	protein transport
H2N74_RS00840	COG0024	Methionine aminopeptidase
H2N74_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2N74_RS00875	COG1122	ATPase activity
H2N74_RS00880	COG1122	ATPase activity
H2N74_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2N74_RS00905	COG2226	methyltransferase
H2N74_RS00910	COG2318	DinB family
H2N74_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS00925	COG0489	protein tyrosine kinase activity
H2N74_RS00935	COG2194	sulfuric ester hydrolase activity
H2N74_RS00940	COG0726	polysaccharide deacetylase
H2N74_RS01000	COG0738	Major facilitator superfamily
H2N74_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
H2N74_RS01025	COG0385	Bile acid
H2N74_RS01030	COG2819	hydrolase of the alpha beta superfamily
H2N74_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2N74_RS01055	COG3876	Protein conserved in bacteria
H2N74_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
H2N74_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2N74_RS01070	COG1263	PTS System
H2N74_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2N74_RS01085	COG1683	Conserved Protein
H2N74_RS01115	COG1595	DNA-templated transcription, initiation
H2N74_RS01120	COG5662	AntiSigma factor
H2N74_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H2N74_RS01130	COG4856	YbbR-like protein
H2N74_RS01170	COG1346	cytolysis
H2N74_RS01175	COG1380	Effector of murein hydrolase LrgA
H2N74_RS01180	COG1846	Transcriptional regulator
H2N74_RS01185	COG1113	amino acid transport
H2N74_RS01190	COG1011	Hydrolase
H2N74_RS01195	COG4585	Histidine kinase
H2N74_RS01200	COG2197	response regulator
H2N74_RS01205	COG1131	(ABC) transporter
H2N74_RS01245	COG0531	amino acid
H2N74_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
H2N74_RS01275	COG2271	Major facilitator Superfamily
H2N74_RS01285	COG2368	4-hydroxyphenylacetate
H2N74_RS01295	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS01310	COG0371	Dehydrogenase
H2N74_RS01320	COG1183	phosphatidylcholine synthase activity
H2N74_RS01325	COG0586	Pfam SNARE associated Golgi protein
H2N74_RS01330	COG0688	phosphatidylethanolamine metabolic process
H2N74_RS01345	COG1301	dicarboxylic acid transport
H2N74_RS01350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS01355	COG0833	amino acid
H2N74_RS01360	COG2040	homocysteine
H2N74_RS01365	COG1115	amino acid carrier protein
H2N74_RS01370	COG2066	Belongs to the glutaminase family
H2N74_RS01375	COG4191	Histidine kinase
H2N74_RS01380	COG0784	Response regulator, receiver
H2N74_RS01385	COG3173	Aminoglycoside phosphotransferase
H2N74_RS01400	COG3773	Cell wall hydrolase
H2N74_RS01405	COG3540	Alkaline phosphatase
H2N74_RS01410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2N74_RS01415	COG0805	protein transport
H2N74_RS01425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2N74_RS01430	COG0477	Major facilitator Superfamily
H2N74_RS01435	COG1309	transcriptional regulator
H2N74_RS01440	COG0252	asparaginase activity
H2N74_RS01450	COG3012	SEC-C Motif Domain Protein
H2N74_RS01450	COG1405	negative regulation of cell septum assembly
H2N74_RS01455	COG0667	Aldo Keto reductase
H2N74_RS01465	COG1595	DNA-templated transcription, initiation
H2N74_RS01470	COG1595	DNA-templated transcription, initiation
H2N74_RS01475	COG1876	peptidase activity
H2N74_RS01480	COG0457	Tetratricopeptide repeat
H2N74_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS01490	COG0366	Alpha amylase catalytic
H2N74_RS01495	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2N74_RS01505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2N74_RS01510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS01515	COG2310	stress, protein
H2N74_RS01520	COG2310	stress, protein
H2N74_RS01525	COG2310	stress, protein
H2N74_RS01530	COG0861	Integral membrane protein TerC family
H2N74_RS01540	COG3853	Toxic anion resistance protein (TelA)
H2N74_RS01545	COG0477	Major facilitator Superfamily
H2N74_RS01550	COG0517	IMP dehydrogenase activity
H2N74_RS01550	COG4175	Glycine betaine
H2N74_RS01555	COG4176	ABC-type proline glycine betaine transport system permease component
H2N74_RS01560	COG2113	Glycine betaine
H2N74_RS01565	COG1473	amidohydrolase
H2N74_RS01570	COG1288	antiporter activity
H2N74_RS01580	COG0366	Alpha amylase catalytic
H2N74_RS01595	COG2814	Major facilitator Superfamily
H2N74_RS01600	COG1846	Transcriptional regulator
H2N74_RS01605	COG1280	lysine exporter protein (LysE YggA)
H2N74_RS01610	COG3403	YqcI/YcgG family
H2N74_RS01615	COG1113	amino acid transport
H2N74_RS01620	COG3665	Urea carboxylase-associated protein
H2N74_RS01635	COG1660	Displays ATPase and GTPase activities
H2N74_RS01640	COG1082	Xylose isomerase domain protein TIM barrel
H2N74_RS01645	COG2271	Major facilitator Superfamily
H2N74_RS01650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2N74_RS01655	COG2226	methyltransferase
H2N74_RS01660	COG0583	DNA-binding transcription factor activity
H2N74_RS01665	COG3458	cephalosporin-C deacetylase activity
H2N74_RS01670	COG3541	Predicted nucleotidyltransferase
H2N74_RS01675	COG0506	proline dehydrogenase activity
H2N74_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS01685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2N74_RS01690	COG2508	Transcriptional regulator
H2N74_RS01700	COG1587	Uroporphyrinogen-III synthase
H2N74_RS01700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2N74_RS01705	COG2146	nitrite reductase [NAD(P)H] activity
H2N74_RS01710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2N74_RS01715	COG0243	molybdopterin cofactor binding
H2N74_RS01720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2N74_RS01725	COG2223	nitrite transmembrane transporter activity
H2N74_RS01730	COG0523	cobalamin synthesis protein
H2N74_RS01735	COG1063	alcohol dehydrogenase
H2N74_RS01740	COG1714	RDD family
H2N74_RS01750	COG2723	6-phospho-beta-galactosidase activity
H2N74_RS01760	COG3209	COG3209 Rhs family protein
H2N74_RS01765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2N74_RS01770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H2N74_RS01775	COG1733	regulation of RNA biosynthetic process
H2N74_RS01780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS01785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS01790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS01795	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2N74_RS01810	COG2364	Membrane
H2N74_RS01815	COG1126	abc transporter atp-binding protein
H2N74_RS01820	COG0765	amino acid transport
H2N74_RS01825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS01830	COG0583	DNA-binding transcription factor activity
H2N74_RS01835	COG0163	prenyltransferase activity
H2N74_RS01840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2N74_RS01855	COG3104	oligopeptide transport
H2N74_RS01860	COG5434	Belongs to the glycosyl hydrolase 28 family
H2N74_RS01870	COG0697	spore germination
H2N74_RS01880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2N74_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS01890	COG0456	acetyltransferase
H2N74_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS01900	COG0765	amino acid transport
H2N74_RS01905	COG1126	abc transporter atp-binding protein
H2N74_RS01910	COG1473	amidohydrolase
H2N74_RS01915	COG2079	MmgE PrpD family protein
H2N74_RS01920	COG1136	(ABC) transporter
H2N74_RS01925	COG0577	efflux transmembrane transporter activity
H2N74_RS01930	COG0745	RESPONSE REGULATOR receiver
H2N74_RS01935	COG3850	Histidine kinase
H2N74_RS01935	COG5002	protein histidine kinase activity
H2N74_RS01940	COG0457	Tetratricopeptide repeat
H2N74_RS01955	COG0527	aspartate kinase activity
H2N74_RS01960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS01965	COG4605	iron ion homeostasis
H2N74_RS01970	COG4604	ABC transporter, ATP-binding protein
H2N74_RS01975	COG4607	ABC-type enterochelin transport system periplasmic component
H2N74_RS01980	COG2814	Major facilitator Superfamily
H2N74_RS01985	COG1309	transcriptional regulator
H2N74_RS01990	COG0778	Nitroreductase
H2N74_RS01995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2N74_RS02000	COG0640	Transcriptional regulator
H2N74_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS02010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS02015	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS02020	COG4975	Glucose uptake
H2N74_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS02030	COG4549	nuclear export factor GLE1
H2N74_RS02035	COG1276	copper resistance
H2N74_RS02035	COG2372	response to copper ion
H2N74_RS02040	COG1349	DNA-binding transcription factor activity
H2N74_RS02050	COG2213	PTS system mannitol-specific
H2N74_RS02055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2N74_RS02075	COG0561	phosphatase activity
H2N74_RS02085	COG1914	H( )-stimulated, divalent metal cation uptake system
H2N74_RS02095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H2N74_RS02100	COG1984	allophanate hydrolase subunit 2
H2N74_RS02105	COG1414	Transcriptional regulator
H2N74_RS02110	COG2755	lipolytic protein G-D-S-L family
H2N74_RS02120	COG2329	Antibiotic biosynthesis monooxygenase
H2N74_RS02125	COG0768	penicillin binding
H2N74_RS02130	COG4989	oxidoreductase activity
H2N74_RS02135	COG3711	transcriptional antiterminator
H2N74_RS02140	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS02150	COG1917	Cupin 2, conserved barrel domain protein
H2N74_RS02155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2N74_RS02160	COG3871	stress protein (general stress protein 26)
H2N74_RS02170	COG2814	Major facilitator Superfamily
H2N74_RS02175	COG1522	sequence-specific DNA binding
H2N74_RS02180	COG0551	DNA topoisomerase type I activity
H2N74_RS02180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2N74_RS02185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2N74_RS02190	COG3706	GGDEF domain
H2N74_RS02195	COG5298	Protein conserved in bacteria
H2N74_RS02200	COG1215	transferase activity, transferring glycosyl groups
H2N74_RS02210	COG0531	amino acid
H2N74_RS02215	COG0494	nUDIX hydrolase
H2N74_RS02220	COG0028	Belongs to the TPP enzyme family
H2N74_RS02260	COG1914	H( )-stimulated, divalent metal cation uptake system
H2N74_RS02270	COG4876	unkown
H2N74_RS02280	COG2076	Multidrug Resistance protein
H2N74_RS02285	COG2217	Heavy metal translocating P-type atpase
H2N74_RS02290	COG3729	General stress protein
H2N74_RS02295	COG0662	Cupin 2, conserved barrel domain protein
H2N74_RS02300	COG2329	Antibiotic biosynthesis monooxygenase
H2N74_RS02305	COG3546	catalase activity
H2N74_RS02310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H2N74_RS02315	COG3290	protein histidine kinase activity
H2N74_RS02320	COG4565	transcriptional regulatory protein
H2N74_RS02325	COG1301	dicarboxylic acid transport
H2N74_RS02330	COG0628	permease
H2N74_RS02335	COG1131	(ABC) transporter
H2N74_RS02340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2N74_RS02350	COG1960	acyl-CoA dehydrogenase activity
H2N74_RS02365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H2N74_RS02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS02380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2N74_RS02385	COG0513	Belongs to the DEAD box helicase family
H2N74_RS02390	COG3402	PFAM membrane-flanked domain
H2N74_RS02395	COG3428	Bacterial PH domain
H2N74_RS02400	COG0705	Rhomboid family
H2N74_RS02410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2N74_RS02415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2N74_RS02420	COG0864	Transcriptional regulator
H2N74_RS02425	COG2337	Toxic component of a toxin-antitoxin (TA) module
H2N74_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS02435	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS02440	COG2172	sigma factor antagonist activity
H2N74_RS02445	COG2208	phosphoserine phosphatase activity
H2N74_RS02450	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS02460	COG1191	sigma factor activity
H2N74_RS02465	COG2208	phosphoserine phosphatase activity
H2N74_RS02470	COG2183	response to ionizing radiation
H2N74_RS02525	COG5444	nuclease activity
H2N74_RS02530	COG0457	Tetratricopeptide repeat
H2N74_RS02535	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2N74_RS02540	COG0457	Tetratricopeptide repeat
H2N74_RS02565	COG0477	Major facilitator Superfamily
H2N74_RS02575	COG2030	dehydratase
H2N74_RS02590	COG1959	2 iron, 2 sulfur cluster binding
H2N74_RS02595	COG2910	NAD(P)H-binding
H2N74_RS02605	COG1309	transcriptional regulator
H2N74_RS02620	COG1278	Cold shock
H2N74_RS02625	COG1329	Transcriptional regulator
H2N74_RS02630	COG1937	Protein conserved in bacteria
H2N74_RS02635	COG2210	Belongs to the sulfur carrier protein TusA family
H2N74_RS02645	COG0425	Belongs to the sulfur carrier protein TusA family
H2N74_RS02645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2N74_RS02650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2N74_RS02650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS02655	COG0425	Belongs to the sulfur carrier protein TusA family
H2N74_RS02660	COG0730	response to heat
H2N74_RS02665	COG1794	racemase activity, acting on amino acids and derivatives
H2N74_RS02680	COG3621	Patatin-like phospholipase
H2N74_RS02690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2N74_RS02695	COG1802	Transcriptional regulator
H2N74_RS02700	COG0251	oxidation-reduction process
H2N74_RS02705	COG0814	amino acid
H2N74_RS02710	COG1473	amidohydrolase
H2N74_RS02715	COG1917	Cupin 2, conserved barrel domain protein
H2N74_RS02715	COG2207	Transcriptional regulator
H2N74_RS02725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS02730	COG0477	Major facilitator Superfamily
H2N74_RS02760	COG0662	Cupin 2, conserved barrel domain protein
H2N74_RS02770	COG2318	DinB family
H2N74_RS02800	COG0351	phosphomethylpyrimidine kinase
H2N74_RS02820	COG1064	alcohol dehydrogenase
H2N74_RS02825	COG0789	Transcriptional regulator
H2N74_RS02835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS02850	COG2814	Major facilitator Superfamily
H2N74_RS02855	COG1309	transcriptional regulator
H2N74_RS02860	COG0697	spore germination
H2N74_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS02870	COG5577	PFAM Coat F domain
H2N74_RS02880	COG1063	alcohol dehydrogenase
H2N74_RS02885	COG5577	PFAM Coat F domain
H2N74_RS02895	COG0738	Major facilitator superfamily
H2N74_RS02915	COG4585	Histidine kinase
H2N74_RS02920	COG2197	response regulator
H2N74_RS02925	COG2409	Drug exporters of the RND superfamily
H2N74_RS02930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H2N74_RS02935	COG0477	Major facilitator Superfamily
H2N74_RS02940	COG1959	2 iron, 2 sulfur cluster binding
H2N74_RS02950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2N74_RS02955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS02965	COG2814	Major facilitator Superfamily
H2N74_RS02970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2N74_RS02980	COG0730	response to heat
H2N74_RS02985	COG0456	acetyltransferase
H2N74_RS02990	COG0789	Transcriptional regulator
H2N74_RS02990	COG4978	Transcriptional regulator
H2N74_RS02995	COG0697	spore germination
H2N74_RS03000	COG1051	belongs to the nudix hydrolase family
H2N74_RS03005	COG2226	methyltransferase
H2N74_RS03010	COG0473	3-isopropylmalate dehydrogenase activity
H2N74_RS03015	COG1802	Transcriptional regulator
H2N74_RS03020	COG1819	glycosyl
H2N74_RS03035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2N74_RS03045	COG1388	LysM domain
H2N74_RS03050	COG2814	Major facilitator Superfamily
H2N74_RS03055	COG2188	Transcriptional regulator
H2N74_RS03060	COG2186	Transcriptional regulator
H2N74_RS03065	COG2807	transmembrane transport
H2N74_RS03070	COG2076	Multidrug Resistance protein
H2N74_RS03075	COG2076	Multidrug Resistance protein
H2N74_RS03080	COG1309	transcriptional regulator
H2N74_RS03085	COG0531	amino acid
H2N74_RS03095	COG3832	glyoxalase III activity
H2N74_RS03100	COG0604	alcohol dehydrogenase
H2N74_RS03105	COG2814	Major facilitator Superfamily
H2N74_RS03145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2N74_RS03150	COG0802	atpase or kinase
H2N74_RS03155	COG1214	PFAM Peptidase M22, glycoprotease
H2N74_RS03160	COG0456	acetyltransferase
H2N74_RS03165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2N74_RS03170	COG0488	(ABC) transporter
H2N74_RS03185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2N74_RS03190	COG0805	protein transport
H2N74_RS03200	COG1266	CAAX protease self-immunity
H2N74_RS03220	COG2856	Zn peptidase
H2N74_RS03230	COG1396	sequence-specific DNA binding
H2N74_RS03275	COG5377	YqaJ viral recombinase family
H2N74_RS03280	COG3723	Recombinational DNA repair protein, rece pathway
H2N74_RS03285	COG3935	DnaD domain protein
H2N74_RS03290	COG1484	DNA-dependent DNA replication
H2N74_RS03385	COG1595	DNA-templated transcription, initiation
H2N74_RS03405	COG5484	DNA packaging
H2N74_RS03555	COG0457	Tetratricopeptide repeat
H2N74_RS03560	COG1063	alcohol dehydrogenase
H2N74_RS03565	COG2211	Major facilitator Superfamily
H2N74_RS03570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2N74_RS03580	COG1842	Phage shock protein A
H2N74_RS03585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2N74_RS03590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2N74_RS03595	COG4260	virion core protein, lumpy skin disease virus
H2N74_RS03600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H2N74_RS03600	COG2755	lipolytic protein G-D-S-L family
H2N74_RS03610	COG1595	DNA-templated transcription, initiation
H2N74_RS03615	COG1063	alcohol dehydrogenase
H2N74_RS03620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H2N74_RS03625	COG0823	Involved in the tonB-independent uptake of proteins
H2N74_RS03640	COG2132	Multicopper oxidase
H2N74_RS03645	COG1113	amino acid transport
H2N74_RS03650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H2N74_RS03655	COG0714	Associated with various cellular activities
H2N74_RS03660	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H2N74_RS03665	COG1305	Transglutaminase-like
H2N74_RS03675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2N74_RS03690	COG0436	Aminotransferase
H2N74_RS03695	COG2211	Major facilitator Superfamily
H2N74_RS03710	COG2252	PERMEase
H2N74_RS03715	COG3064	Membrane
H2N74_RS03735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H2N74_RS03740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2N74_RS03745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2N74_RS03750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2N74_RS03755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2N74_RS03770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H2N74_RS03780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2N74_RS03785	COG0138	bifunctional purine biosynthesis protein purh
H2N74_RS03790	COG0151	Belongs to the GarS family
H2N74_RS03800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2N74_RS03805	COG1470	cell adhesion involved in biofilm formation
H2N74_RS03810	COG4496	protein, YerC YecD
H2N74_RS03815	COG0069	glutamate synthase activity
H2N74_RS03825	COG0210	DNA helicase
H2N74_RS03835	COG4851	CamS sex pheromone cAM373 precursor
H2N74_RS03840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2N74_RS03845	COG1285	pathogenesis
H2N74_RS03850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2N74_RS03870	COG1309	transcriptional regulator
H2N74_RS03875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2N74_RS03880	COG1597	lipid kinase activity
H2N74_RS03885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2N74_RS03895	COG1131	(ABC) transporter
H2N74_RS03940	COG5444	nuclease activity
H2N74_RS03970	COG3546	catalase activity
H2N74_RS03975	COG0454	-acetyltransferase
H2N74_RS03985	COG2323	membrane
H2N74_RS03990	COG2329	Antibiotic biosynthesis monooxygenase
H2N74_RS03995	COG0346	lactoylglutathione lyase activity
H2N74_RS04000	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS04005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2N74_RS04010	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2N74_RS04015	COG4208	sulfate ABC transporter
H2N74_RS04025	COG5583	Uncharacterized small protein (DUF2292)
H2N74_RS04030	COG0196	riboflavin kinase activity
H2N74_RS04035	COG0670	Belongs to the BI1 family
H2N74_RS04040	COG1846	Transcriptional regulator
H2N74_RS04045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2N74_RS04055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2N74_RS04055	COG2124	cytochrome p450
H2N74_RS04060	COG1368	sulfuric ester hydrolase activity
H2N74_RS04065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2N74_RS04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS04075	COG1442	glycosyl transferase family 8
H2N74_RS04080	COG1216	Glycosyl transferase, family 2
H2N74_RS04085	COG1442	glycosyl transferase family 8
H2N74_RS04090	COG2223	nitrite transmembrane transporter activity
H2N74_RS04095	COG0531	amino acid
H2N74_RS04100	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS04105	COG0840	transmembrane signaling receptor activity
H2N74_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS04115	COG0463	Glycosyl transferase, family 2
H2N74_RS04120	COG0488	(ABC) transporter
H2N74_RS04125	COG0789	Transcriptional regulator
H2N74_RS04130	COG2814	Major facilitator Superfamily
H2N74_RS04135	COG0488	(ABC) transporter
H2N74_RS04140	COG0513	Belongs to the DEAD box helicase family
H2N74_RS04145	COG0456	acetyltransferase
H2N74_RS04150	COG2130	NADP-dependent
H2N74_RS04165	COG3866	Pectate lyase
H2N74_RS04170	COG0471	metal ion transport
H2N74_RS04190	COG0745	RESPONSE REGULATOR receiver
H2N74_RS04190	COG2972	Histidine kinase
H2N74_RS04195	COG3279	Response regulator of the LytR AlgR family
H2N74_RS04205	COG3764	Sortase (surface protein transpeptidase)
H2N74_RS04210	COG3290	protein histidine kinase activity
H2N74_RS04215	COG4565	transcriptional regulatory protein
H2N74_RS04220	COG3181	Tripartite tricarboxylate transporter family receptor
H2N74_RS04225	COG2851	Citrate transporter
H2N74_RS04230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS04235	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H2N74_RS04245	COG2258	MOSC domain
H2N74_RS04265	COG0024	Methionine aminopeptidase
H2N74_RS04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS04270	COG1263	PTS System
H2N74_RS04280	COG1368	sulfuric ester hydrolase activity
H2N74_RS04290	COG0071	Belongs to the small heat shock protein (HSP20) family
H2N74_RS04305	COG1263	PTS System
H2N74_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS04310	COG0366	Alpha amylase catalytic
H2N74_RS04315	COG2188	Transcriptional regulator
H2N74_RS04320	COG0778	Nitroreductase
H2N74_RS04335	COG0737	Belongs to the 5'-nucleotidase family
H2N74_RS04340	COG0693	protein deglycase activity
H2N74_RS04345	COG1609	Transcriptional regulator
H2N74_RS04360	COG2814	Major facilitator Superfamily
H2N74_RS04370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2N74_RS04375	COG4980	gas vesicle protein
H2N74_RS04380	COG1295	ribonuclease BN
H2N74_RS04385	COG0477	Major facilitator Superfamily
H2N74_RS04390	COG0387	Pfam Sodium calcium exchanger
H2N74_RS04400	COG0668	transmembrane transport
H2N74_RS04405	COG0535	radical SAM domain protein
H2N74_RS04415	COG0726	polysaccharide deacetylase
H2N74_RS04420	COG2084	Dehydrogenase
H2N74_RS04430	COG0598	Magnesium transport protein CorA
H2N74_RS04435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H2N74_RS04440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2N74_RS04450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2N74_RS04455	COG4637	Psort location Cytoplasmic, score
H2N74_RS04460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2N74_RS04465	COG0022	dehydrogenase e1 component
H2N74_RS04470	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2N74_RS04475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2N74_RS04480	COG3284	Transcriptional regulator
H2N74_RS04490	COG1486	melibiose metabolic process
H2N74_RS04495	COG1737	Transcriptional regulator
H2N74_RS04500	COG1263	PTS System
H2N74_RS04500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS04505	COG5434	Belongs to the glycosyl hydrolase 28 family
H2N74_RS04510	COG1132	(ABC) transporter
H2N74_RS04515	COG1132	(ABC) transporter
H2N74_RS04520	COG2259	Doxx family
H2N74_RS04525	COG2514	catechol 2,3-dioxygenase activity
H2N74_RS04535	COG1695	Transcriptional regulator
H2N74_RS04540	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2N74_RS04545	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H2N74_RS04550	COG0574	Belongs to the PEP-utilizing enzyme family
H2N74_RS04550	COG3848	Pyruvate phosphate dikinase
H2N74_RS04555	COG2732	(Barnase) inhibitor
H2N74_RS04560	COG2318	DinB family
H2N74_RS04565	COG2814	Major facilitator Superfamily
H2N74_RS04570	COG1846	Transcriptional regulator
H2N74_RS04575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H2N74_RS04575	COG0392	lysyltransferase activity
H2N74_RS04580	COG0384	phenazine biosynthesis protein PhzF
H2N74_RS04585	COG0778	Nitroreductase
H2N74_RS04600	COG1090	epimerase
H2N74_RS04615	COG2814	Major facilitator Superfamily
H2N74_RS04625	COG3591	Belongs to the peptidase S1B family
H2N74_RS04640	COG3103	Sh3 type 3 domain protein
H2N74_RS04645	COG5658	integral membrane protein
H2N74_RS04650	COG0596	Alpha beta hydrolase
H2N74_RS04655	COG0463	Glycosyl transferase, family 2
H2N74_RS04660	COG4485	Bacterial membrane protein, YfhO
H2N74_RS04665	COG1988	membrane-bound metal-dependent
H2N74_RS04670	COG1194	a g-specific adenine glycosylase
H2N74_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS04700	COG1132	(ABC) transporter
H2N74_RS04705	COG4129	membrane
H2N74_RS04715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2N74_RS04720	COG0735	belongs to the Fur family
H2N74_RS04835	COG3340	Belongs to the peptidase S51 family
H2N74_RS04845	COG0277	FAD linked oxidase domain protein
H2N74_RS04855	COG0747	negative chemotaxis
H2N74_RS04860	COG0601	transmembrane transport
H2N74_RS04865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2N74_RS04870	COG0444	Belongs to the ABC transporter superfamily
H2N74_RS04875	COG4608	Belongs to the ABC transporter superfamily
H2N74_RS04880	COG0753	catalase activity
H2N74_RS04890	COG1116	anion transmembrane transporter activity
H2N74_RS04895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2N74_RS04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2N74_RS04920	COG1476	TRANSCRIPTIONal
H2N74_RS04930	COG3382	B3 4 domain protein
H2N74_RS04935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2N74_RS04945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2N74_RS04950	COG0789	Transcriptional regulator
H2N74_RS04955	COG1664	Polymer-forming cytoskeletal
H2N74_RS04960	COG1664	Polymer-forming cytoskeletal
H2N74_RS04965	COG2766	serine protein kinase
H2N74_RS04975	COG1846	Transcriptional regulator
H2N74_RS04980	COG1566	PFAM secretion protein HlyD family protein
H2N74_RS04985	COG2814	Major facilitator Superfamily
H2N74_RS04990	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2N74_RS05005	COG1725	Transcriptional regulator
H2N74_RS05010	COG1131	(ABC) transporter
H2N74_RS05015	COG1131	(ABC) transporter
H2N74_RS05020	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2N74_RS05025	COG1278	Cold shock
H2N74_RS05030	COG1464	Belongs to the NlpA lipoprotein family
H2N74_RS05035	COG3706	GGDEF domain
H2N74_RS05040	COG1823	symporter activity
H2N74_RS05060	COG5577	PFAM Coat F domain
H2N74_RS05065	COG4085	toxin activity
H2N74_RS05065	COG0737	Belongs to the 5'-nucleotidase family
H2N74_RS05065	COG1525	nuclease
H2N74_RS05070	COG3764	Sortase (surface protein transpeptidase)
H2N74_RS05075	COG0564	pseudouridine synthase activity
H2N74_RS05085	COG0517	IMP dehydrogenase activity
H2N74_RS05090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2N74_RS05095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2N74_RS05095	COG3153	acetyltransferase
H2N74_RS05100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2N74_RS05105	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H2N74_RS05110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2N74_RS05120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H2N74_RS05125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2N74_RS05140	COG0431	NADPH-dependent FMN reductase
H2N74_RS05155	COG1388	LysM domain
H2N74_RS05155	COG0791	NLP P60 protein
H2N74_RS05160	COG1959	2 iron, 2 sulfur cluster binding
H2N74_RS05165	COG0668	transmembrane transport
H2N74_RS05170	COG2719	SpoVR family
H2N74_RS05175	COG1785	Belongs to the alkaline phosphatase family
H2N74_RS05180	COG1388	LysM domain
H2N74_RS05180	COG0791	NLP P60 protein
H2N74_RS05185	COG0583	DNA-binding transcription factor activity
H2N74_RS05190	COG0372	Belongs to the citrate synthase family
H2N74_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS05200	COG0531	amino acid
H2N74_RS05205	COG0733	neurotransmitter:sodium symporter activity
H2N74_RS05220	COG1595	DNA-templated transcription, initiation
H2N74_RS05225	COG0204	Acyl-transferase
H2N74_RS05230	COG1253	flavin adenine dinucleotide binding
H2N74_RS05235	COG0789	Transcriptional regulator
H2N74_RS05240	COG0436	Aminotransferase
H2N74_RS05245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2N74_RS05250	COG1253	flavin adenine dinucleotide binding
H2N74_RS05255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2N74_RS05260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2N74_RS05265	COG0584	glycerophosphoryl diester phosphodiesterase
H2N74_RS05275	COG0668	transmembrane transport
H2N74_RS05280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H2N74_RS05285	COG0726	polysaccharide deacetylase
H2N74_RS05290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS05295	COG3226	Transcriptional regulator
H2N74_RS05305	COG0589	response to stress
H2N74_RS05310	COG1132	(ABC) transporter
H2N74_RS05315	COG1132	(ABC) transporter
H2N74_RS05320	COG0702	epimerase
H2N74_RS05335	COG0189	ligase activity
H2N74_RS05340	COG0189	ligase activity
H2N74_RS05355	COG4335	DNA alkylation repair
H2N74_RS05360	COG0561	phosphatase activity
H2N74_RS05365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2N74_RS05375	COG0475	glutathione-regulated potassium exporter activity
H2N74_RS05380	COG0490	domain, Protein
H2N74_RS05390	COG1024	Enoyl-CoA hydratase
H2N74_RS05405	COG1668	transmembrane transport
H2N74_RS05410	COG0420	3'-5' exonuclease activity
H2N74_RS05415	COG4717	serine-type aminopeptidase activity
H2N74_RS05430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2N74_RS05465	COG4980	gas vesicle protein
H2N74_RS05480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2N74_RS05485	COG0537	adenosine 5'-monophosphoramidase activity
H2N74_RS05490	COG1131	(ABC) transporter
H2N74_RS05495	COG4473	ABC transporter
H2N74_RS05505	COG1473	amidohydrolase
H2N74_RS05510	COG3069	C4-dicarboxylate transmembrane transporter activity
H2N74_RS05515	COG2329	Antibiotic biosynthesis monooxygenase
H2N74_RS05520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2N74_RS05540	COG1309	transcriptional regulator
H2N74_RS05545	COG1511	domain protein
H2N74_RS05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2N74_RS05560	COG1363	Peptidase, m42
H2N74_RS05565	COG1301	dicarboxylic acid transport
H2N74_RS05575	COG1234	tRNA 3'-trailer cleavage
H2N74_RS05580	COG0095	Lipoate-protein ligase
H2N74_RS05585	COG0702	epimerase
H2N74_RS05590	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS05600	COG0501	Belongs to the peptidase M48B family
H2N74_RS05605	COG1404	Belongs to the peptidase S8 family
H2N74_RS05610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H2N74_RS05615	COG0406	alpha-ribazole phosphatase activity
H2N74_RS05620	COG0183	Belongs to the thiolase family
H2N74_RS05625	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS05630	COG1268	BioY protein
H2N74_RS05635	COG0840	transmembrane signaling receptor activity
H2N74_RS05640	COG0723	plastoquinol--plastocyanin reductase activity
H2N74_RS05640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2N74_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS05655	COG4903	ComK protein
H2N74_RS05660	COG5646	InterPro IPR014922
H2N74_RS05665	COG5646	InterPro IPR014922
H2N74_RS05690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2N74_RS05705	COG0398	Pfam SNARE associated Golgi protein
H2N74_RS05710	COG0681	Belongs to the peptidase S26 family
H2N74_RS05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2N74_RS05720	COG1846	Transcriptional regulator
H2N74_RS05725	COG3180	Ammonia monooxygenase
H2N74_RS05730	COG2814	Major facilitator Superfamily
H2N74_RS05740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H2N74_RS05745	COG2323	membrane
H2N74_RS05760	COG0420	3'-5' exonuclease activity
H2N74_RS05765	COG0419	ATPase involved in DNA repair
H2N74_RS05770	COG1403	HNH endonuclease
H2N74_RS05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2N74_RS05825	COG0367	asparagine synthase
H2N74_RS05830	COG1562	ergosterol biosynthetic process
H2N74_RS05835	COG0534	Mate efflux family protein
H2N74_RS05840	COG1917	Cupin 2, conserved barrel domain protein
H2N74_RS05840	COG2207	Transcriptional regulator
H2N74_RS05845	COG1609	Transcriptional regulator
H2N74_RS05850	COG0673	inositol 2-dehydrogenase activity
H2N74_RS05855	COG2318	DinB family
H2N74_RS05860	COG1357	PFAM Pentapeptide repeats (8 copies)
H2N74_RS05865	COG2153	protein acetylation
H2N74_RS05870	COG0646	methionine synthase
H2N74_RS05870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2N74_RS05880	COG2996	Protein conserved in bacteria
H2N74_RS05890	COG0840	transmembrane signaling receptor activity
H2N74_RS05895	COG2124	cytochrome p450
H2N74_RS05905	COG1307	EDD domain protein, DegV family
H2N74_RS05910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS05930	COG0561	phosphatase activity
H2N74_RS05935	COG1073	alpha beta
H2N74_RS05940	COG2151	metal-sulfur cluster biosynthetic enzyme
H2N74_RS05950	COG0277	FAD linked oxidase domain protein
H2N74_RS05955	COG2271	Major facilitator Superfamily
H2N74_RS05965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2N74_RS05975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2N74_RS05980	COG0505	Belongs to the CarA family
H2N74_RS05985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2N74_RS05990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2N74_RS06005	COG2267	carboxylic ester hydrolase activity
H2N74_RS06015	COG1744	ABC transporter substrate-binding protein PnrA-like
H2N74_RS06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2N74_RS06035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2N74_RS06040	COG5504	Zn-dependent protease
H2N74_RS06045	COG0444	Belongs to the ABC transporter superfamily
H2N74_RS06050	COG4608	Belongs to the ABC transporter superfamily
H2N74_RS06060	COG0601	transmembrane transport
H2N74_RS06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2N74_RS06075	COG0180	Tryptophanyl-tRNA synthetase
H2N74_RS06080	COG4166	transmembrane transport
H2N74_RS06085	COG0601	transmembrane transport
H2N74_RS06090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2N74_RS06095	COG0444	Belongs to the ABC transporter superfamily
H2N74_RS06100	COG4608	Belongs to the ABC transporter superfamily
H2N74_RS06110	COG0456	acetyltransferase
H2N74_RS06115	COG1393	Belongs to the ArsC family
H2N74_RS06120	COG0861	Integral membrane protein TerC family
H2N74_RS06125	COG4862	establishment of competence for transformation
H2N74_RS06130	COG4469	Competence protein
H2N74_RS06135	COG1164	Oligoendopeptidase f
H2N74_RS06150	COG2346	COG2346, Truncated hemoglobins
H2N74_RS06155	COG0741	lytic transglycosylase activity
H2N74_RS06160	COG4116	CYTH
H2N74_RS06170	COG2357	RelA SpoT domain protein
H2N74_RS06175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2N74_RS06180	COG0564	pseudouridine synthase activity
H2N74_RS06190	COG0569	domain protein
H2N74_RS06190	COG0475	glutathione-regulated potassium exporter activity
H2N74_RS06195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2N74_RS06200	COG0352	thiamine-phosphate diphosphorylase activity
H2N74_RS06205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2N74_RS06210	COG2104	thiamine diphosphate biosynthetic process
H2N74_RS06220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2N74_RS06225	COG0351	phosphomethylpyrimidine kinase
H2N74_RS06230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H2N74_RS06285	COG0210	DNA helicase
H2N74_RS06305	COG1131	(ABC) transporter
H2N74_RS06315	COG2153	protein acetylation
H2N74_RS06325	COG2382	esterase
H2N74_RS06330	COG0626	cystathionine gamma-synthase activity
H2N74_RS06335	COG0626	cystathionine gamma-synthase activity
H2N74_RS06365	COG5444	nuclease activity
H2N74_RS06380	COG0135	phosphoribosylanthranilate isomerase activity
H2N74_RS06395	COG2367	Beta-lactamase
H2N74_RS06400	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2N74_RS06405	COG0477	Major facilitator Superfamily
H2N74_RS06410	COG1846	Transcriptional regulator
H2N74_RS06420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H2N74_RS06425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2N74_RS06430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H2N74_RS06435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS06435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS06440	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2N74_RS06470	COG1285	pathogenesis
H2N74_RS06485	COG2205	protein histidine kinase activity
H2N74_RS06495	COG3383	formate dehydrogenase (NAD+) activity
H2N74_RS06500	COG2427	Protein of unknown function (DUF1641)
H2N74_RS06505	COG2124	cytochrome p450
H2N74_RS06510	COG1819	glycosyl
H2N74_RS06520	COG1587	Uroporphyrinogen-III synthase
H2N74_RS06525	COG0390	transport system, permease component
H2N74_RS06530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2N74_RS06535	COG0697	spore germination
H2N74_RS06540	COG4297	protein containing double-stranded beta helix domain
H2N74_RS06550	COG1252	NADH dehydrogenase
H2N74_RS06560	COG2211	Major facilitator Superfamily
H2N74_RS06565	COG1609	Transcriptional regulator
H2N74_RS06570	COG0246	Mannitol dehydrogenase
H2N74_RS06575	COG2721	sulfolactate sulfo-lyase activity
H2N74_RS06580	COG0745	RESPONSE REGULATOR receiver
H2N74_RS06585	COG2205	protein histidine kinase activity
H2N74_RS06585	COG2770	Histidine kinase
H2N74_RS06605	COG4585	Histidine kinase
H2N74_RS06610	COG2197	response regulator
H2N74_RS06645	COG0730	response to heat
H2N74_RS06650	COG2318	DinB family
H2N74_RS06655	COG0457	Tetratricopeptide repeat
H2N74_RS06665	COG1388	LysM domain
H2N74_RS06665	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS06665	COG5632	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS06675	COG4195	phage-related replication protein
H2N74_RS06680	COG2856	Zn peptidase
H2N74_RS06685	COG1396	sequence-specific DNA binding
H2N74_RS06695	COG1522	sequence-specific DNA binding
H2N74_RS06700	COG1484	DNA-dependent DNA replication
H2N74_RS06720	COG1595	DNA-templated transcription, initiation
H2N74_RS06725	COG5484	DNA packaging
H2N74_RS06725	COG3728	DNA packaging
H2N74_RS06730	COG1783	phage Terminase large subunit
H2N74_RS06735	COG5518	Phage portal protein
H2N74_RS06740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H2N74_RS06745	COG4653	Phage capsid family
H2N74_RS06795	COG3953	SLT domain
H2N74_RS06795	COG3953	SLT domain
H2N74_RS06795	COG5412	phage tail tape measure protein
H2N74_RS06795	COG3953	SLT domain
H2N74_RS06795	COG5412	phage tail tape measure protein
H2N74_RS06795	COG5412	phage tail tape measure protein
H2N74_RS06800	COG1652	LysM domain
H2N74_RS06805	COG4193	domain, Protein
H2N74_RS06815	COG3628	GPW Gp25 family protein
H2N74_RS06820	COG3299	homolog of phage Mu protein gp47
H2N74_RS06825	COG3778	Protein conserved in bacteria
H2N74_RS06865	COG5632	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS06865	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS06880	COG0306	phosphate transporter
H2N74_RS06885	COG1392	Phosphate transport regulator
H2N74_RS06890	COG0531	amino acid
H2N74_RS06895	COG0346	lactoylglutathione lyase activity
H2N74_RS06900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H2N74_RS06905	COG0463	Glycosyl transferase, family 2
H2N74_RS06915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2N74_RS06920	COG0477	Major facilitator Superfamily
H2N74_RS06925	COG2362	D-Aminopeptidase
H2N74_RS06930	COG0601	transmembrane transport
H2N74_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2N74_RS06940	COG0444	Belongs to the ABC transporter superfamily
H2N74_RS06945	COG4166	transmembrane transport
H2N74_RS06950	COG1619	proteins homologs of microcin C7 resistance protein MccF
H2N74_RS06955	COG4948	Mandelate Racemase Muconate Lactonizing
H2N74_RS06960	COG0791	NLP P60 protein
H2N74_RS06965	COG4608	Belongs to the ABC transporter superfamily
H2N74_RS06975	COG2706	6-phosphogluconolactonase activity
H2N74_RS06980	COG1834	amidinotransferase
H2N74_RS06985	COG1607	acyl-coa hydrolase
H2N74_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2N74_RS06995	COG2076	Multidrug Resistance protein
H2N74_RS07000	COG2076	Multidrug Resistance protein
H2N74_RS07005	COG0788	formyltetrahydrofolate deformylase activity
H2N74_RS07010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2N74_RS07020	COG1764	response to oxidative stress
H2N74_RS07025	COG1846	Transcriptional regulator
H2N74_RS07030	COG1764	response to oxidative stress
H2N74_RS07045	COG0463	Glycosyl transferase, family 2
H2N74_RS07045	COG0457	Tetratricopeptide repeat
H2N74_RS07055	COG2814	Major facilitator Superfamily
H2N74_RS07060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2N74_RS07070	COG1404	Belongs to the peptidase S8 family
H2N74_RS07075	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS07080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H2N74_RS07085	COG1122	ATPase activity
H2N74_RS07090	COG4721	ABC-type cobalt transport system, permease component
H2N74_RS07095	COG1388	LysM domain
H2N74_RS07095	COG3858	chitin binding
H2N74_RS07105	COG2239	Acts as a magnesium transporter
H2N74_RS07115	COG0789	Transcriptional regulator
H2N74_RS07130	COG1846	Transcriptional regulator
H2N74_RS07135	COG0726	polysaccharide deacetylase
H2N74_RS07140	COG1793	dna ligase
H2N74_RS07140	COG3285	dna ligase
H2N74_RS07145	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H2N74_RS07150	COG0586	Pfam SNARE associated Golgi protein
H2N74_RS07155	COG0861	Integral membrane protein TerC family
H2N74_RS07160	COG1191	sigma factor activity
H2N74_RS07185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2N74_RS07190	COG2323	membrane
H2N74_RS07200	COG3594	Acyltransferase
H2N74_RS07205	COG5002	protein histidine kinase activity
H2N74_RS07210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2N74_RS07225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2N74_RS07230	COG0436	Aminotransferase
H2N74_RS07260	COG3852	Histidine kinase
H2N74_RS07265	COG1846	Transcriptional regulator
H2N74_RS07270	COG1360	Flagellar Motor Protein
H2N74_RS07275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H2N74_RS07280	COG0542	response to heat
H2N74_RS07285	COG3949	Membrane
H2N74_RS07300	COG0720	synthase
H2N74_RS07305	COG0602	queuosine metabolic process
H2N74_RS07315	COG1733	regulation of RNA biosynthetic process
H2N74_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS07340	COG4873	Protein conserved in bacteria
H2N74_RS07350	COG3773	Cell wall hydrolase
H2N74_RS07355	COG2244	polysaccharide biosynthetic process
H2N74_RS07360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS07365	COG2217	Heavy metal translocating P-type atpase
H2N74_RS07370	COG0006	proline dipeptidase activity
H2N74_RS07375	COG1609	Transcriptional regulator
H2N74_RS07380	COG3711	transcriptional antiterminator
H2N74_RS07385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS07385	COG1263	PTS System
H2N74_RS07385	COG2190	(PTS) system
H2N74_RS07390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS07395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2N74_RS07405	COG1533	DNA photolyase activity
H2N74_RS07410	COG0840	transmembrane signaling receptor activity
H2N74_RS07415	COG2084	Dehydrogenase
H2N74_RS07420	COG2340	Cysteine-rich secretory protein family
H2N74_RS07425	COG0768	penicillin binding
H2N74_RS07430	COG4191	Histidine kinase
H2N74_RS07435	COG0436	Aminotransferase
H2N74_RS07445	COG0835	chemotaxis
H2N74_RS07445	COG0784	Response regulator, receiver
H2N74_RS07455	COG2814	Major facilitator Superfamily
H2N74_RS07460	COG1376	ErfK ybiS ycfS ynhG family protein
H2N74_RS07465	COG1408	metallophosphoesterase
H2N74_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS07480	COG2200	EAL domain
H2N74_RS07485	COG4703	Protein of unknown function (DUF1797)
H2N74_RS07490	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H2N74_RS07500	COG0517	IMP dehydrogenase activity
H2N74_RS07505	COG0583	DNA-binding transcription factor activity
H2N74_RS07510	COG0716	FMN binding
H2N74_RS07540	COG0668	transmembrane transport
H2N74_RS07545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS07565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2N74_RS07570	COG0303	'Molybdopterin
H2N74_RS07575	COG1763	Mo-molybdopterin cofactor biosynthetic process
H2N74_RS07580	COG0314	molybdopterin synthase activity
H2N74_RS07585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H2N74_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2N74_RS07600	COG1136	(ABC) transporter
H2N74_RS07605	COG0577	efflux transmembrane transporter activity
H2N74_RS07610	COG1349	DNA-binding transcription factor activity
H2N74_RS07615	COG1105	Belongs to the carbohydrate kinase PfkB family
H2N74_RS07620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2N74_RS07620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2N74_RS07620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS07625	COG0681	Belongs to the peptidase S26 family
H2N74_RS07635	COG0488	(ABC) transporter
H2N74_RS07640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2N74_RS07645	COG2309	aminopeptidase activity
H2N74_RS07655	COG1077	Cell shape determining protein MreB Mrl
H2N74_RS07660	COG2002	toxin-antitoxin pair type II binding
H2N74_RS07665	COG3852	Histidine kinase
H2N74_RS07670	COG2105	PFAM AIG2 family protein
H2N74_RS07670	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H2N74_RS07675	COG0569	domain protein
H2N74_RS07685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2N74_RS07695	COG0561	phosphatase activity
H2N74_RS07700	COG0242	peptide deformylase activity
H2N74_RS07710	COG0497	DNA recombination
H2N74_RS07720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS07720	COG3321	synthase
H2N74_RS07720	COG4221	oxidoreductase activity
H2N74_RS07725	COG0300	oxidoreductase activity
H2N74_RS07725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS07725	COG4221	oxidoreductase activity
H2N74_RS07725	COG3321	synthase
H2N74_RS07730	COG4221	oxidoreductase activity
H2N74_RS07730	COG3321	synthase
H2N74_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS07730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS07735	COG4221	oxidoreductase activity
H2N74_RS07735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS07735	COG3321	synthase
H2N74_RS07735	COG0300	oxidoreductase activity
H2N74_RS07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS07740	COG4221	oxidoreductase activity
H2N74_RS07740	COG3321	synthase
H2N74_RS07740	COG0300	oxidoreductase activity
H2N74_RS07745	COG3321	synthase
H2N74_RS07745	COG4221	oxidoreductase activity
H2N74_RS07745	COG0300	oxidoreductase activity
H2N74_RS07745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS07750	COG4221	oxidoreductase activity
H2N74_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS07750	COG3321	synthase
H2N74_RS07750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS07755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2N74_RS07760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2N74_RS07765	COG0022	dehydrogenase e1 component
H2N74_RS07770	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2N74_RS07775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2N74_RS07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS07795	COG1982	Orn Lys Arg decarboxylase major
H2N74_RS07815	COG0483	inositol monophosphate 1-phosphatase activity
H2N74_RS07825	COG3227	Zinc metalloprotease (Elastase)
H2N74_RS07860	COG4896	Protein conserved in bacteria
H2N74_RS07870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H2N74_RS07875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2N74_RS07880	COG2066	Belongs to the glutaminase family
H2N74_RS07890	COG0772	Belongs to the SEDS family
H2N74_RS07895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H2N74_RS07910	COG2010	Cytochrome c
H2N74_RS07910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2N74_RS07915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2N74_RS07920	COG1845	cytochrome c oxidase, subunit III
H2N74_RS07925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2N74_RS07930	COG3336	cytochrome c oxidase
H2N74_RS07940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H2N74_RS07945	COG2340	Cysteine-rich secretory protein family
H2N74_RS07960	COG3679	Belongs to the UPF0342 family
H2N74_RS07970	COG0742	ribosomal rna small subunit methyltransferase
H2N74_RS07980	COG3314	Sporulation integral membrane protein YlbJ
H2N74_RS07985	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2N74_RS07990	COG3480	Lon protease (S16) C-terminal proteolytic domain
H2N74_RS08005	COG1399	metal-binding, possibly nucleic acid-binding protein
H2N74_RS08025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H2N74_RS08045	COG4839	cell division protein FtsL
H2N74_RS08055	COG0768	penicillin binding
H2N74_RS08075	COG0772	Belongs to the SEDS family
H2N74_RS08090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2N74_RS08095	COG0849	cell division
H2N74_RS08100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2N74_RS08105	COG4412	M6 family metalloprotease domain protein
H2N74_RS08105	COG1404	Belongs to the peptidase S8 family
H2N74_RS08115	COG1191	sigma factor activity
H2N74_RS08120	COG1191	sigma factor activity
H2N74_RS08125	COG1119	ATPase activity
H2N74_RS08130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2N74_RS08135	COG1873	PFAM PRC-barrel domain
H2N74_RS08145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H2N74_RS08155	COG0762	integral membrane protein
H2N74_RS08160	COG2302	S4 RNA-binding domain
H2N74_RS08165	COG3599	regulation of cell shape
H2N74_RS08170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2N74_RS08175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2N74_RS08185	COG0564	pseudouridine synthase activity
H2N74_RS08195	COG2233	PERMEase
H2N74_RS08205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2N74_RS08210	COG0505	Belongs to the CarA family
H2N74_RS08215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H2N74_RS08230	COG0284	orotidine-5'-phosphate decarboxylase activity
H2N74_RS08235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2N74_RS08245	COG0306	phosphate transporter
H2N74_RS08260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2N74_RS08265	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H2N74_RS08270	COG1648	precorrin-2 dehydrogenase activity
H2N74_RS08280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2N74_RS08285	COG1561	YicC-like family, N-terminal region
H2N74_RS08295	COG0194	GDP metabolic process
H2N74_RS08305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2N74_RS08310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2N74_RS08315	COG0242	peptide deformylase activity
H2N74_RS08325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2N74_RS08325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H2N74_RS08335	COG0631	protein serine/threonine phosphatase activity
H2N74_RS08340	COG2815	serine threonine protein kinase
H2N74_RS08340	COG0515	serine threonine protein kinase
H2N74_RS08350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2N74_RS08355	COG1564	THIamine pyrophosphokinase
H2N74_RS08370	COG1302	Protein conserved in bacteria
H2N74_RS08375	COG1461	Dihydroxyacetone kinase
H2N74_RS08380	COG1760	l-serine dehydratase
H2N74_RS08385	COG1760	l-serine dehydratase
H2N74_RS08390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2N74_RS08405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2N74_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS08425	COG1196	nuclear chromosome segregation
H2N74_RS08430	COG0552	protein localization to endoplasmic reticulum
H2N74_RS08445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2N74_RS08455	COG1837	Belongs to the UPF0109 family
H2N74_RS08480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H2N74_RS08495	COG2257	FlhB HrpN YscU SpaS Family
H2N74_RS08505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2N74_RS08510	COG0758	DNA mediated transformation
H2N74_RS08515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2N74_RS08525	COG4974	Belongs to the 'phage' integrase family
H2N74_RS08545	COG1815	bacterial-type flagellum-dependent cell motility
H2N74_RS08550	COG1558	bacterial-type flagellum-dependent cell motility
H2N74_RS08555	COG1677	Flagellar hook-basal body complex protein FliE
H2N74_RS08560	COG1766	The M ring may be actively involved in energy transduction
H2N74_RS08565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2N74_RS08570	COG1317	bacterial-type flagellum organization
H2N74_RS08575	COG1157	protein secretion by the type III secretion system
H2N74_RS08580	COG2882	bacterial-type flagellum organization
H2N74_RS08585	COG3334	PFAM MgtE intracellular
H2N74_RS08590	COG3144	bacterial-type flagellum assembly
H2N74_RS08595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H2N74_RS08600	COG4786	Flagellar basal body rod
H2N74_RS08605	COG1582	Flagellar protein (FlbD)
H2N74_RS08610	COG1580	Controls the rotational direction of flagella during chemotaxis
H2N74_RS08615	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H2N74_RS08625	COG2201	protein-glutamate methylesterase activity
H2N74_RS08630	COG3190	flagellar
H2N74_RS08635	COG1338	Plays a role in the flagellum-specific transport system
H2N74_RS08640	COG1987	bacterial-type flagellum assembly
H2N74_RS08645	COG1684	flagellar biosynthetic protein fliR
H2N74_RS08650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2N74_RS08655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2N74_RS08660	COG1419	protein localization to endoplasmic reticulum
H2N74_RS08665	COG0455	bacterial-type flagellum organization
H2N74_RS08670	COG2201	protein-glutamate methylesterase activity
H2N74_RS08675	COG0643	Histidine kinase
H2N74_RS08675	COG2198	Histidine kinase
H2N74_RS08680	COG0835	chemotaxis
H2N74_RS08685	COG1776	CheC inhibitor of MCP methylation
H2N74_RS08695	COG1191	sigma factor activity
H2N74_RS08725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2N74_RS08730	COG4589	Belongs to the CDS family
H2N74_RS08740	COG0750	zinc metalloprotease
H2N74_RS08750	COG2176	DNA-directed DNA polymerase activity
H2N74_RS08760	COG0195	Participates in both transcription termination and antitermination
H2N74_RS08765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H2N74_RS08770	COG1358	cellular component organization or biogenesis
H2N74_RS08780	COG1550	Protein conserved in bacteria
H2N74_RS08795	COG0196	riboflavin kinase activity
H2N74_RS08810	COG0726	polysaccharide deacetylase
H2N74_RS08815	COG0612	Peptidase, M16
H2N74_RS08820	COG1873	PFAM PRC-barrel domain
H2N74_RS08825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2N74_RS08830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2N74_RS08835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2N74_RS08840	COG0527	aspartate kinase activity
H2N74_RS08850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H2N74_RS08855	COG0740	serine-type endopeptidase activity
H2N74_RS08865	COG4980	gas vesicle protein
H2N74_RS08865	COG1674	ftsk spoiiie
H2N74_RS08870	COG2188	Transcriptional regulator
H2N74_RS08875	COG2814	Major facilitator Superfamily
H2N74_RS08880	COG1846	Transcriptional regulator
H2N74_RS08885	COG1033	growth of symbiont in host cell
H2N74_RS08885	COG2409	Drug exporters of the RND superfamily
H2N74_RS08890	COG0612	Peptidase, M16
H2N74_RS08895	COG0612	Peptidase, M16
H2N74_RS08900	COG0300	oxidoreductase activity
H2N74_RS08915	COG1426	Protein conserved in bacteria
H2N74_RS08920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2N74_RS08935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2N74_RS08945	COG1692	metallophosphoesterase
H2N74_RS08950	COG2359	stage V sporulation protein S
H2N74_RS08970	COG4550	Control of competence regulator ComK, YlbF/YmcA
H2N74_RS09025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS09030	COG3425	synthase
H2N74_RS09035	COG1024	Enoyl-CoA hydratase
H2N74_RS09040	COG1024	Enoyl-CoA hydratase
H2N74_RS09045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09045	COG0300	oxidoreductase activity
H2N74_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS09045	COG3321	synthase
H2N74_RS09050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS09050	COG4221	oxidoreductase activity
H2N74_RS09050	COG0300	oxidoreductase activity
H2N74_RS09050	COG3321	synthase
H2N74_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09055	COG3321	synthase
H2N74_RS09055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS09055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS09055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS09055	COG3321	synthase
H2N74_RS09060	COG3321	synthase
H2N74_RS09060	COG4221	oxidoreductase activity
H2N74_RS09060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2N74_RS09065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2N74_RS09065	COG3321	synthase
H2N74_RS09065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS09070	COG2124	cytochrome p450
H2N74_RS09075	COG3209	COG3209 Rhs family protein
H2N74_RS09080	COG3619	membrane
H2N74_RS09090	COG1404	Belongs to the peptidase S8 family
H2N74_RS09100	COG4195	phage-related replication protein
H2N74_RS09105	COG1764	response to oxidative stress
H2N74_RS09115	COG2076	Multidrug Resistance protein
H2N74_RS09155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2N74_RS09160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2N74_RS09165	COG4112	unkown
H2N74_RS09175	COG0464	growth
H2N74_RS09180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2N74_RS09185	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H2N74_RS09190	COG0789	Transcriptional regulator
H2N74_RS09195	COG0174	glutamine synthetase
H2N74_RS09210	COG2211	Major facilitator Superfamily
H2N74_RS09215	COG3507	Belongs to the glycosyl hydrolase 43 family
H2N74_RS09230	COG1070	Carbohydrate kinase
H2N74_RS09235	COG3848	Pyruvate phosphate dikinase
H2N74_RS09235	COG0574	Belongs to the PEP-utilizing enzyme family
H2N74_RS09260	COG2378	regulation of single-species biofilm formation
H2N74_RS09265	COG2318	DinB family
H2N74_RS09270	COG1064	alcohol dehydrogenase
H2N74_RS09290	COG0456	acetyltransferase
H2N74_RS09295	COG5444	nuclease activity
H2N74_RS09335	COG3397	chitin binding
H2N74_RS09350	COG5434	Belongs to the glycosyl hydrolase 28 family
H2N74_RS09355	COG0756	dUTP diphosphatase activity
H2N74_RS09360	COG4195	phage-related replication protein
H2N74_RS09395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H2N74_RS09405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2N74_RS09425	COG0785	Cytochrome C biogenesis protein
H2N74_RS09430	COG2201	protein-glutamate methylesterase activity
H2N74_RS09435	COG4846	Membrane protein involved in cytochrome C biogenesis
H2N74_RS09445	COG0071	Belongs to the small heat shock protein (HSP20) family
H2N74_RS09460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2N74_RS09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS09485	COG0824	Thioesterase
H2N74_RS09495	COG4841	protein insertion into membrane
H2N74_RS09505	COG1832	CoA-binding protein
H2N74_RS09510	COG0187	DNA topoisomerase II activity
H2N74_RS09515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H2N74_RS09525	COG1115	amino acid carrier protein
H2N74_RS09535	COG1063	alcohol dehydrogenase
H2N74_RS09540	COG0800	Aldolase
H2N74_RS09545	COG1312	Catalyzes the dehydration of D-mannonate
H2N74_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09555	COG1609	Transcriptional regulator
H2N74_RS09560	COG2271	Major facilitator Superfamily
H2N74_RS09610	COG2205	protein histidine kinase activity
H2N74_RS09615	COG0745	RESPONSE REGULATOR receiver
H2N74_RS09625	COG3507	Belongs to the glycosyl hydrolase 43 family
H2N74_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS09655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2N74_RS09660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2N74_RS09665	COG2610	gluconate transmembrane transporter activity
H2N74_RS09670	COG2124	cytochrome p450
H2N74_RS09690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2N74_RS09700	COG2246	polysaccharide biosynthetic process
H2N74_RS09705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2N74_RS09710	COG0586	Pfam SNARE associated Golgi protein
H2N74_RS09715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2N74_RS09720	COG1024	Enoyl-CoA hydratase
H2N74_RS09725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2N74_RS09730	COG0511	ligase activity, forming carbon-carbon bonds
H2N74_RS09735	COG0439	Biotin carboxylase
H2N74_RS09740	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS09745	COG1960	acyl-CoA dehydrogenase activity
H2N74_RS09750	COG1649	PFAM Uncharacterised BCR, COG1649
H2N74_RS09760	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2N74_RS09760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS09785	COG2027	D-alanyl-D-alanine carboxypeptidase
H2N74_RS09790	COG2017	converts alpha-aldose to the beta-anomer
H2N74_RS09795	COG0534	Mate efflux family protein
H2N74_RS09810	COG0582	viral genome integration into host DNA
H2N74_RS09815	COG0166	Belongs to the GPI family
H2N74_RS09820	COG0405	Gamma-glutamyltransferase
H2N74_RS09825	COG2814	Major facilitator Superfamily
H2N74_RS09830	COG0640	Transcriptional regulator
H2N74_RS09835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2N74_RS09845	COG0604	alcohol dehydrogenase
H2N74_RS09855	COG0493	'glutamate synthase
H2N74_RS09860	COG0070	glutamate synthase
H2N74_RS09860	COG0069	glutamate synthase activity
H2N74_RS09860	COG0067	glutamate synthase
H2N74_RS09865	COG0583	DNA-binding transcription factor activity
H2N74_RS09870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2N74_RS09885	COG0300	oxidoreductase activity
H2N74_RS09890	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H2N74_RS09900	COG2814	Major facilitator Superfamily
H2N74_RS09905	COG1070	Carbohydrate kinase
H2N74_RS09910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2N74_RS09915	COG0243	molybdopterin cofactor binding
H2N74_RS09945	COG5444	nuclease activity
H2N74_RS09950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2N74_RS09955	COG2207	Transcriptional regulator
H2N74_RS09955	COG0662	Cupin 2, conserved barrel domain protein
H2N74_RS09960	COG1309	transcriptional regulator
H2N74_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS09975	COG0640	Transcriptional regulator
H2N74_RS09980	COG0741	lytic transglycosylase activity
H2N74_RS09985	COG2322	membrane
H2N74_RS10000	COG1619	proteins homologs of microcin C7 resistance protein MccF
H2N74_RS10010	COG1388	LysM domain
H2N74_RS10010	COG3584	3D domain protein
H2N74_RS10015	COG0514	ATP-dependent DNA helicase (RecQ)
H2N74_RS10025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2N74_RS10030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2N74_RS10045	COG0071	Belongs to the small heat shock protein (HSP20) family
H2N74_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS10080	COG1657	PFAM Prenyltransferase squalene oxidase
H2N74_RS10085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2N74_RS10090	COG0733	neurotransmitter:sodium symporter activity
H2N74_RS10095	COG0385	Bile acid
H2N74_RS10100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS10105	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2N74_RS10115	COG4548	von Willebrand factor, type A
H2N74_RS10120	COG0714	Associated with various cellular activities
H2N74_RS10125	COG2032	superoxide dismutase activity
H2N74_RS10130	COG1388	LysM domain
H2N74_RS10130	COG0791	NLP P60 protein
H2N74_RS10135	COG1819	glycosyl
H2N74_RS10140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H2N74_RS10145	COG0534	Mate efflux family protein
H2N74_RS10150	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS10155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2N74_RS10160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2N74_RS10170	COG2962	Rard protein
H2N74_RS10185	COG1942	4-Oxalocrotonate Tautomerase
H2N74_RS10195	COG1733	regulation of RNA biosynthetic process
H2N74_RS10200	COG0778	Nitroreductase
H2N74_RS10205	COG0400	carboxylic ester hydrolase activity
H2N74_RS10210	COG0346	lactoylglutathione lyase activity
H2N74_RS10220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2N74_RS10230	COG2723	6-phospho-beta-galactosidase activity
H2N74_RS10235	COG2188	Transcriptional regulator
H2N74_RS10240	COG0793	Belongs to the peptidase S41A family
H2N74_RS10240	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS10245	COG2226	methyltransferase
H2N74_RS10255	COG1876	peptidase activity
H2N74_RS10275	COG0671	phosphoesterase, PA-phosphatase related
H2N74_RS10305	COG1509	lysine 2,3-aminomutase activity
H2N74_RS10310	COG0456	acetyltransferase
H2N74_RS10315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2N74_RS10320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2N74_RS10325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2N74_RS10330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2N74_RS10335	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H2N74_RS10345	COG0456	acetyltransferase
H2N74_RS10350	COG0463	Glycosyl transferase, family 2
H2N74_RS10365	COG4641	Protein conserved in bacteria
H2N74_RS10375	COG1086	Polysaccharide biosynthesis protein
H2N74_RS10395	COG1388	LysM domain
H2N74_RS10400	COG0457	Tetratricopeptide repeat
H2N74_RS10460	COG3655	Transcriptional regulator
H2N74_RS10500	COG4282	regulation of fungal-type cell wall biogenesis
H2N74_RS10505	COG1525	nuclease
H2N74_RS10520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H2N74_RS10540	COG1846	Transcriptional regulator
H2N74_RS10545	COG4698	Protein conserved in bacteria
H2N74_RS10550	COG2755	lipolytic protein G-D-S-L family
H2N74_RS10555	COG1999	signal sequence binding
H2N74_RS10565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2N74_RS10570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H2N74_RS10575	COG1272	protein, Hemolysin III
H2N74_RS10585	COG0204	Acyl-transferase
H2N74_RS10590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H2N74_RS10605	COG2136	Putative SAM-dependent methyltransferase
H2N74_RS10605	COG2521	methyltransferase
H2N74_RS10620	COG1413	lyase activity
H2N74_RS10625	COG1418	mRNA catabolic process
H2N74_RS10630	COG0386	Belongs to the glutathione peroxidase family
H2N74_RS10640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2N74_RS10650	COG1278	Cold shock
H2N74_RS10670	COG0328	RNA-DNA hybrid ribonuclease activity
H2N74_RS10675	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H2N74_RS10680	COG0328	RNA-DNA hybrid ribonuclease activity
H2N74_RS10690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2N74_RS10705	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2N74_RS10715	COG1755	Isoprenylcysteine carboxyl methyltransferase
H2N74_RS10720	COG3424	synthase
H2N74_RS10745	COG1335	isochorismatase
H2N74_RS10750	COG2233	PERMEase
H2N74_RS10760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H2N74_RS10765	COG1199	ATP-dependent helicase activity
H2N74_RS10780	COG0116	Belongs to the methyltransferase superfamily
H2N74_RS10810	COG3359	exonuclease
H2N74_RS10815	COG1205	dead DEAH box helicase
H2N74_RS10815	COG1111	helicase
H2N74_RS10820	COG2190	(PTS) system
H2N74_RS10825	COG0071	Belongs to the small heat shock protein (HSP20) family
H2N74_RS10865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2N74_RS10865	COG4499	WXG100 protein secretion system (Wss), protein YukC
H2N74_RS10875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2N74_RS10880	COG3935	DnaD domain protein
H2N74_RS10890	COG0436	Aminotransferase
H2N74_RS10895	COG5353	protein conserved in bacteria
H2N74_RS10905	COG1199	ATP-dependent helicase activity
H2N74_RS10905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2N74_RS10935	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS10940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2N74_RS10955	COG1694	Mazg nucleotide pyrophosphohydrolase
H2N74_RS10960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS10965	COG2140	Oxalate decarboxylase
H2N74_RS10975	COG4347	Protein of unknown function (DUF1405)
H2N74_RS10980	COG2010	Cytochrome c
H2N74_RS10980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2N74_RS10985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2N74_RS10990	COG0723	plastoquinol--plastocyanin reductase activity
H2N74_RS11005	COG0457	Tetratricopeptide repeat
H2N74_RS11015	COG0287	Prephenate dehydrogenase
H2N74_RS11050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2N74_RS11055	COG4401	Chorismate mutase type I
H2N74_RS11070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H2N74_RS11075	COG0105	UTP biosynthetic process
H2N74_RS11080	COG0142	geranyltranstransferase activity
H2N74_RS11090	COG0142	geranyltranstransferase activity
H2N74_RS11105	COG0776	regulation of translation
H2N74_RS11110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2N74_RS11150	COG0539	negative regulation of cytoplasmic translation
H2N74_RS11165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H2N74_RS11170	COG2959	enzyme of heme biosynthesis
H2N74_RS11175	COG3773	Cell wall hydrolase
H2N74_RS11175	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS11180	COG2339	peptidase activity
H2N74_RS11185	COG0492	ferredoxin-NADP+ reductase activity
H2N74_RS11190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2N74_RS11195	COG4862	establishment of competence for transformation
H2N74_RS11200	COG1408	metallophosphoesterase
H2N74_RS11210	COG1388	LysM domain
H2N74_RS11215	COG1266	CAAX protease self-immunity
H2N74_RS11220	COG0514	ATP-dependent DNA helicase (RecQ)
H2N74_RS11225	COG4955	Helix-turn-helix domain
H2N74_RS11230	COG1141	Ferredoxin
H2N74_RS11235	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H2N74_RS11240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2N74_RS11250	COG1595	DNA-templated transcription, initiation
H2N74_RS11255	COG5002	protein histidine kinase activity
H2N74_RS11260	COG0745	RESPONSE REGULATOR receiver
H2N74_RS11265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2N74_RS11270	COG1333	cytochrome c biogenesis protein
H2N74_RS11275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS11280	COG1187	pseudouridine synthase activity
H2N74_RS11285	COG0700	Nucleoside recognition
H2N74_RS11290	COG2715	membrane protein required for spore maturation
H2N74_RS11295	COG1686	Belongs to the peptidase S11 family
H2N74_RS11320	COG1547	Domain of unknown function (DUF309)
H2N74_RS11325	COG0456	acetyltransferase
H2N74_RS11340	COG0307	riboflavin synthase, alpha
H2N74_RS11345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2N74_RS11345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2N74_RS11355	COG0681	Belongs to the peptidase S26 family
H2N74_RS11365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2N74_RS11370	COG4086	secreted protein
H2N74_RS11375	COG0019	diaminopimelate decarboxylase activity
H2N74_RS11380	COG0697	spore germination
H2N74_RS11395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2N74_RS11415	COG1191	sigma factor activity
H2N74_RS11425	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS11430	COG1686	Belongs to the peptidase S11 family
H2N74_RS11435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H2N74_RS11440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H2N74_RS11445	COG4974	Belongs to the 'phage' integrase family
H2N74_RS11455	COG0735	belongs to the Fur family
H2N74_RS11460	COG1300	Membrane
H2N74_RS11475	COG0281	malic enzyme
H2N74_RS11480	COG1757	Na H antiporter
H2N74_RS11485	COG1027	Aspartate ammonia-lyase
H2N74_RS11490	COG0252	asparaginase activity
H2N74_RS11495	COG1396	sequence-specific DNA binding
H2N74_RS11500	COG1379	DNA repair
H2N74_RS11505	COG0494	nUDIX hydrolase
H2N74_RS11515	COG0667	Aldo Keto reductase
H2N74_RS11525	COG1073	alpha beta
H2N74_RS11535	COG4918	Iron-sulphur cluster biosynthesis
H2N74_RS11540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2N74_RS11540	COG0456	acetyltransferase
H2N74_RS11545	COG2329	Antibiotic biosynthesis monooxygenase
H2N74_RS11550	COG0456	acetyltransferase
H2N74_RS11555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2N74_RS11570	COG0628	permease
H2N74_RS11580	COG0346	lactoylglutathione lyase activity
H2N74_RS11590	COG3048	D-serine ammonia-lyase activity
H2N74_RS11595	COG0300	oxidoreductase activity
H2N74_RS11600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS11605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2N74_RS11610	COG1024	Enoyl-CoA hydratase
H2N74_RS11615	COG3425	synthase
H2N74_RS11620	COG2124	cytochrome p450
H2N74_RS11625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS11625	COG3321	synthase
H2N74_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS11625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS11630	COG3321	synthase
H2N74_RS11630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11635	COG0300	oxidoreductase activity
H2N74_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11635	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS11635	COG3321	synthase
H2N74_RS11640	COG0300	oxidoreductase activity
H2N74_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11640	COG3321	synthase
H2N74_RS11640	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS11645	COG3321	synthase
H2N74_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS11645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS11650	COG3321	synthase
H2N74_RS11650	COG0300	oxidoreductase activity
H2N74_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS11650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11655	COG3321	synthase
H2N74_RS11655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2N74_RS11655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS11655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2N74_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS11665	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS11680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2N74_RS11680	COG2070	2-Nitropropane dioxygenase
H2N74_RS11685	COG0250	Participates in transcription elongation, termination and antitermination
H2N74_RS11710	COG0596	Alpha beta hydrolase
H2N74_RS11725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2N74_RS11730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H2N74_RS11745	COG0706	membrane insertase activity
H2N74_RS11750	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2N74_RS11755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2N74_RS11760	COG0346	lactoylglutathione lyase activity
H2N74_RS11770	COG1376	ErfK ybiS ycfS ynhG family protein
H2N74_RS11775	COG4129	membrane
H2N74_RS11780	COG1126	abc transporter atp-binding protein
H2N74_RS11785	COG0765	amino acid transport
H2N74_RS11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS11800	COG1597	lipid kinase activity
H2N74_RS11805	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2N74_RS11810	COG0022	dehydrogenase e1 component
H2N74_RS11815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2N74_RS11820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2N74_RS11825	COG3426	butyrate kinase activity
H2N74_RS11830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2N74_RS11835	COG0280	phosphate acetyltransferase
H2N74_RS11840	COG3829	transcription factor binding
H2N74_RS11840	COG3290	protein histidine kinase activity
H2N74_RS11850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H2N74_RS11855	COG2079	MmgE PrpD family protein
H2N74_RS11860	COG0372	Belongs to the citrate synthase family
H2N74_RS11865	COG1960	acyl-CoA dehydrogenase activity
H2N74_RS11870	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2N74_RS11875	COG0183	Belongs to the thiolase family
H2N74_RS11880	COG0584	glycerophosphoryl diester phosphodiesterase
H2N74_RS11885	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS11910	COG1902	pentaerythritol trinitrate reductase activity
H2N74_RS11925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2N74_RS11930	COG0745	RESPONSE REGULATOR receiver
H2N74_RS11935	COG0750	zinc metalloprotease
H2N74_RS11940	COG0497	DNA recombination
H2N74_RS11950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H2N74_RS11960	COG0142	geranyltranstransferase activity
H2N74_RS11970	COG1570	exodeoxyribonuclease VII activity
H2N74_RS11985	COG1302	Protein conserved in bacteria
H2N74_RS11990	COG0439	Biotin carboxylase
H2N74_RS11995	COG0511	ligase activity, forming carbon-carbon bonds
H2N74_RS12035	COG3854	ATPases associated with a variety of cellular activities
H2N74_RS12050	COG0006	proline dipeptidase activity
H2N74_RS12060	COG3872	metal-dependent enzyme
H2N74_RS12070	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2N74_RS12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2N74_RS12105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2N74_RS12120	COG1396	sequence-specific DNA binding
H2N74_RS12130	COG0681	Belongs to the peptidase S26 family
H2N74_RS12155	COG4940	Competence protein ComGF
H2N74_RS12165	COG4970	Tfp pilus assembly protein FimT
H2N74_RS12170	COG4537	Required for transformation and DNA binding
H2N74_RS12175	COG1459	type II secretion system
H2N74_RS12180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2N74_RS12185	COG0598	Magnesium transport protein CorA
H2N74_RS12190	COG1253	flavin adenine dinucleotide binding
H2N74_RS12195	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS12205	COG1393	Belongs to the ArsC family
H2N74_RS12215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS12225	COG0011	TIGRFAM Protein of
H2N74_RS12235	COG2866	Carboxypeptidase
H2N74_RS12240	COG1940	carbohydrate kinase activity
H2N74_RS12245	COG4483	Protein conserved in bacteria
H2N74_RS12250	COG1757	Na H antiporter
H2N74_RS12260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2N74_RS12275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2N74_RS12280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2N74_RS12285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2N74_RS12290	COG0581	inorganic phosphate transmembrane transporter activity
H2N74_RS12295	COG0573	inorganic phosphate transmembrane transporter activity
H2N74_RS12300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2N74_RS12310	COG0477	Major facilitator Superfamily
H2N74_RS12315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2N74_RS12320	COG2839	Protein conserved in bacteria
H2N74_RS12325	COG5521	maltodextrose utilization protein MalA
H2N74_RS12330	COG1388	LysM domain
H2N74_RS12340	COG4709	membrane
H2N74_RS12345	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H2N74_RS12350	COG0735	belongs to the Fur family
H2N74_RS12355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS12370	COG0513	Belongs to the DEAD box helicase family
H2N74_RS12385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2N74_RS12390	COG2384	SAM-dependent methyltransferase
H2N74_RS12395	COG2010	Cytochrome c
H2N74_RS12400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2N74_RS12405	COG0358	DNA primase activity
H2N74_RS12420	COG0517	IMP dehydrogenase activity
H2N74_RS12425	COG0751	glycine-tRNA ligase activity
H2N74_RS12445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2N74_RS12450	COG0295	cytidine deaminase activity
H2N74_RS12455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H2N74_RS12465	COG1480	7TM receptor with intracellular HD hydrolase
H2N74_RS12470	COG1702	phosphate starvation-inducible protein PhoH
H2N74_RS12475	COG0561	phosphatase activity
H2N74_RS12490	COG4864	UPF0365 protein
H2N74_RS12495	COG1030	water channel activity
H2N74_RS12500	COG1610	YqeY-like protein
H2N74_RS12510	COG1283	sodium-dependent phosphate transmembrane transporter activity
H2N74_RS12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2N74_RS12520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2N74_RS12550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2N74_RS12565	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS12580	COG1466	dna polymerase III delta subunit
H2N74_RS12595	COG2333	competence protein COMEC
H2N74_RS12595	COG0658	competence protein
H2N74_RS12600	COG2131	deaminase
H2N74_RS12605	COG1596	polysaccharide export
H2N74_RS12605	COG1555	photosystem II stabilization
H2N74_RS12610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H2N74_RS12615	COG2226	methyltransferase
H2N74_RS12620	COG0799	negative regulation of ribosome biogenesis
H2N74_RS12625	COG1713	HD superfamily hydrolase involved in NAD metabolism
H2N74_RS12635	COG1534	Rna-binding protein
H2N74_RS12640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2N74_RS12645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H2N74_RS12650	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H2N74_RS12660	COG2755	lipolytic protein G-D-S-L family
H2N74_RS12670	COG0398	Pfam SNARE associated Golgi protein
H2N74_RS12690	COG1794	racemase activity, acting on amino acids and derivatives
H2N74_RS12700	COG1733	regulation of RNA biosynthetic process
H2N74_RS12760	COG3708	Transcriptional regulator
H2N74_RS12760	COG2207	Transcriptional regulator
H2N74_RS12765	COG0583	DNA-binding transcription factor activity
H2N74_RS12780	COG5002	protein histidine kinase activity
H2N74_RS12780	COG0642	Histidine kinase
H2N74_RS12785	COG0745	RESPONSE REGULATOR receiver
H2N74_RS12800	COG0454	-acetyltransferase
H2N74_RS12815	COG2814	Major facilitator Superfamily
H2N74_RS12825	COG0456	acetyltransferase
H2N74_RS12830	COG2318	DinB family
H2N74_RS12840	COG0561	phosphatase activity
H2N74_RS12845	COG0561	phosphatase activity
H2N74_RS12855	COG1482	cell wall glycoprotein biosynthetic process
H2N74_RS12860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS12860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2N74_RS12860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2N74_RS12865	COG3711	transcriptional antiterminator
H2N74_RS12865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS12875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2N74_RS12880	COG0583	DNA-binding transcription factor activity
H2N74_RS12885	COG2814	Major facilitator Superfamily
H2N74_RS12890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2N74_RS12890	COG2124	cytochrome p450
H2N74_RS12895	COG1309	transcriptional regulator
H2N74_RS12900	COG2226	methyltransferase
H2N74_RS12915	COG2116	formate transmembrane transporter activity
H2N74_RS12920	COG5609	conserved protein (DUF2294)
H2N74_RS12925	COG3383	formate dehydrogenase (NAD+) activity
H2N74_RS12930	COG2427	Protein of unknown function (DUF1641)
H2N74_RS12940	COG0626	cystathionine gamma-synthase activity
H2N74_RS12945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2N74_RS12970	COG0768	penicillin binding
H2N74_RS12995	COG4122	O-methyltransferase activity
H2N74_RS13000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2N74_RS13015	COG4472	Bacterial protein of unknown function (DUF965)
H2N74_RS13025	COG0628	permease
H2N74_RS13030	COG1126	abc transporter atp-binding protein
H2N74_RS13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS13040	COG0765	amino acid transport
H2N74_RS13045	COG0765	amino acid transport
H2N74_RS13060	COG3881	PFAM PRC-barrel domain
H2N74_RS13065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2N74_RS13070	COG0457	Tetratricopeptide repeat
H2N74_RS13080	COG1104	cysteine desulfurase activity
H2N74_RS13085	COG1959	2 iron, 2 sulfur cluster binding
H2N74_RS13090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2N74_RS13095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2N74_RS13120	COG3103	Sh3 type 3 domain protein
H2N74_RS13120	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS13120	COG4991	sh3 domain protein
H2N74_RS13130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2N74_RS13140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H2N74_RS13140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2N74_RS13145	COG5416	Lipopolysaccharide assembly protein A domain
H2N74_RS13150	COG0490	domain, Protein
H2N74_RS13155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2N74_RS13155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2N74_RS13165	COG2244	polysaccharide biosynthetic process
H2N74_RS13170	COG2323	membrane
H2N74_RS13180	COG1862	Preprotein translocase
H2N74_RS13225	COG1388	LysM domain
H2N74_RS13235	COG0157	Belongs to the NadC ModD family
H2N74_RS13240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2N74_RS13245	COG1104	cysteine desulfurase activity
H2N74_RS13250	COG1827	regulation of RNA biosynthetic process
H2N74_RS13255	COG0077	Prephenate dehydratase
H2N74_RS13270	COG3290	protein histidine kinase activity
H2N74_RS13275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2N74_RS13280	COG2868	ribosomal protein
H2N74_RS13290	COG1994	Peptidase M50
H2N74_RS13295	COG0739	heme binding
H2N74_RS13300	COG2894	cell division
H2N74_RS13310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2N74_RS13320	COG1077	Cell shape determining protein MreB Mrl
H2N74_RS13340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H2N74_RS13345	COG0285	dihydrofolate synthase activity
H2N74_RS13350	COG0525	valine-tRNA ligase activity
H2N74_RS13360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2N74_RS13365	COG1388	LysM domain
H2N74_RS13375	COG0113	porphobilinogen synthase activity
H2N74_RS13380	COG1587	Uroporphyrinogen-III synthase
H2N74_RS13390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2N74_RS13410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H2N74_RS13415	COG0470	DNA polymerase III
H2N74_RS13415	COG1067	ATP-dependent peptidase activity
H2N74_RS13430	COG0457	Tetratricopeptide repeat
H2N74_RS13430	COG1477	protein flavinylation
H2N74_RS13445	COG0473	3-isopropylmalate dehydrogenase activity
H2N74_RS13460	COG0440	acetolactate synthase activity
H2N74_RS13465	COG0028	Belongs to the TPP enzyme family
H2N74_RS13490	COG0622	Phosphoesterase
H2N74_RS13495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2N74_RS13505	COG5401	PFAM Sporulation and spore germination
H2N74_RS13515	COG1846	Transcriptional regulator
H2N74_RS13520	COG2197	response regulator
H2N74_RS13525	COG0824	Thioesterase
H2N74_RS13530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2N74_RS13535	COG1053	succinate dehydrogenase
H2N74_RS13540	COG2009	succinate dehydrogenase
H2N74_RS13545	COG1719	4-vinyl reductase, 4VR
H2N74_RS13550	COG0527	aspartate kinase activity
H2N74_RS13560	COG3118	belongs to the thioredoxin family
H2N74_RS13565	COG3534	alpha-L-arabinofuranosidase
H2N74_RS13570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2N74_RS13575	COG2086	electron transfer activity
H2N74_RS13580	COG1024	Enoyl-CoA hydratase
H2N74_RS13585	COG1309	transcriptional regulator
H2N74_RS13590	COG0318	PFAM AMP-dependent synthetase and ligase
H2N74_RS13600	COG3766	membrane
H2N74_RS13610	COG1796	DNA polymerase
H2N74_RS13610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2N74_RS13615	COG1286	toxin biosynthetic process
H2N74_RS13630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2N74_RS13630	COG0072	phenylalanine-tRNA ligase activity
H2N74_RS13635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2N74_RS13640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2N74_RS13650	COG3835	regulator
H2N74_RS13655	COG0277	FAD linked oxidase domain protein
H2N74_RS13660	COG0247	lactate metabolic process
H2N74_RS13665	COG1966	Carbon starvation protein
H2N74_RS13670	COG3534	alpha-L-arabinofuranosidase
H2N74_RS13675	COG0395	ABC-type sugar transport system, permease component
H2N74_RS13680	COG1175	transmembrane transport
H2N74_RS13685	COG1653	transport
H2N74_RS13695	COG0647	UMP catabolic process
H2N74_RS13700	COG0235	Class ii aldolase
H2N74_RS13705	COG1069	ribulokinase activity
H2N74_RS13710	COG2160	L-arabinose isomerase activity
H2N74_RS13715	COG3507	Belongs to the glycosyl hydrolase 43 family
H2N74_RS13720	COG1363	Peptidase, m42
H2N74_RS13730	COG3326	Membrane
H2N74_RS13745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2N74_RS13750	COG1346	cytolysis
H2N74_RS13755	COG1380	Effector of murein hydrolase LrgA
H2N74_RS13760	COG3279	Response regulator of the LytR AlgR family
H2N74_RS13765	COG3275	phosphorelay sensor kinase activity
H2N74_RS13770	COG1011	Hydrolase
H2N74_RS13785	COG0398	Pfam SNARE associated Golgi protein
H2N74_RS13790	COG1484	DNA-dependent DNA replication
H2N74_RS13795	COG3611	Membrane attachment protein
H2N74_RS13810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2N74_RS13815	COG1733	regulation of RNA biosynthetic process
H2N74_RS13820	COG2814	Major facilitator Superfamily
H2N74_RS13825	COG0656	L-ascorbic acid biosynthetic process
H2N74_RS13830	COG0237	dephospho-CoA kinase activity
H2N74_RS13835	COG1971	Probably functions as a manganese efflux pump
H2N74_RS13840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2N74_RS13845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2N74_RS13845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H2N74_RS13850	COG5002	protein histidine kinase activity
H2N74_RS13855	COG0745	RESPONSE REGULATOR receiver
H2N74_RS13865	COG0538	isocitrate dehydrogenase activity
H2N74_RS13870	COG0372	Belongs to the citrate synthase family
H2N74_RS13875	COG0457	Tetratricopeptide repeat
H2N74_RS13900	COG0628	permease
H2N74_RS13905	COG3030	protein affecting phage T7 exclusion by the F plasmid
H2N74_RS13910	COG0469	pyruvate kinase activity
H2N74_RS13930	COG0281	malic enzyme
H2N74_RS13935	COG0587	DNA-directed DNA polymerase activity
H2N74_RS13955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2N74_RS13965	COG4109	DRTGG domain
H2N74_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS13990	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2N74_RS14000	COG0827	DNA restriction-modification system
H2N74_RS14005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H2N74_RS14010	COG3874	Sporulation protein YtfJ
H2N74_RS14020	COG1714	RDD family
H2N74_RS14025	COG0616	signal peptide processing
H2N74_RS14030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2N74_RS14035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H2N74_RS14040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2N74_RS14055	COG1104	cysteine desulfurase activity
H2N74_RS14060	COG1114	Component of the transport system for branched-chain amino acids
H2N74_RS14070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H2N74_RS14075	COG1309	transcriptional regulator
H2N74_RS14080	COG1956	GAF domain-containing protein
H2N74_RS14085	COG2203	Gaf domain
H2N74_RS14085	COG2199	diguanylate cyclase activity
H2N74_RS14095	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS14100	COG0457	Tetratricopeptide repeat
H2N74_RS14120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2N74_RS14120	COG1017	nitric oxide dioxygenase activity
H2N74_RS14135	COG0693	protein deglycase activity
H2N74_RS14150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H2N74_RS14155	COG1378	Sugar-specific transcriptional regulator TrmB
H2N74_RS14175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2N74_RS14180	COG0454	-acetyltransferase
H2N74_RS14185	COG0517	IMP dehydrogenase activity
H2N74_RS14190	COG0123	including yeast histone deacetylase and acetoin utilization protein
H2N74_RS14195	COG1360	Flagellar Motor Protein
H2N74_RS14200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H2N74_RS14205	COG1609	Transcriptional regulator
H2N74_RS14210	COG1605	Chorismate mutase
H2N74_RS14210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2N74_RS14215	COG3118	belongs to the thioredoxin family
H2N74_RS14220	COG4980	gas vesicle protein
H2N74_RS14225	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H2N74_RS14235	COG1674	ftsk spoiiie
H2N74_RS14240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2N74_RS14250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS14260	COG1363	Peptidase, m42
H2N74_RS14265	COG5584	Small secreted protein
H2N74_RS14270	COG0281	malic enzyme
H2N74_RS14275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2N74_RS14290	COG0510	thiamine kinase activity
H2N74_RS14295	COG1597	lipid kinase activity
H2N74_RS14305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H2N74_RS14310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2N74_RS14315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2N74_RS14320	COG2252	PERMEase
H2N74_RS14325	COG4473	ABC transporter
H2N74_RS14330	COG1131	(ABC) transporter
H2N74_RS14335	COG1349	DNA-binding transcription factor activity
H2N74_RS14340	COG1187	pseudouridine synthase activity
H2N74_RS14345	COG2244	polysaccharide biosynthetic process
H2N74_RS14350	COG2081	HI0933 family
H2N74_RS14355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2N74_RS14365	COG1609	Transcriptional regulator
H2N74_RS14370	COG1653	transport
H2N74_RS14375	COG1175	transmembrane transport
H2N74_RS14380	COG0395	ABC-type sugar transport system, permease component
H2N74_RS14385	COG1486	melibiose metabolic process
H2N74_RS14395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2N74_RS14410	COG2202	Pas domain
H2N74_RS14410	COG1366	Belongs to the anti-sigma-factor antagonist family
H2N74_RS14415	COG2814	Major facilitator Superfamily
H2N74_RS14420	COG5522	Integral membrane protein (intg_mem_TP0381)
H2N74_RS14425	COG0577	efflux transmembrane transporter activity
H2N74_RS14430	COG1136	(ABC) transporter
H2N74_RS14435	COG2205	protein histidine kinase activity
H2N74_RS14440	COG0745	RESPONSE REGULATOR receiver
H2N74_RS14445	COG0577	efflux transmembrane transporter activity
H2N74_RS14450	COG1136	(ABC) transporter
H2N74_RS14470	COG1131	(ABC) transporter
H2N74_RS14475	COG1725	Transcriptional regulator
H2N74_RS14485	COG1242	4 iron, 4 sulfur cluster binding
H2N74_RS14490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H2N74_RS14500	COG0584	glycerophosphoryl diester phosphodiesterase
H2N74_RS14510	COG2267	carboxylic ester hydrolase activity
H2N74_RS14515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2N74_RS14520	COG1113	amino acid transport
H2N74_RS14525	COG0367	asparagine synthase
H2N74_RS14545	COG1506	peptidase
H2N74_RS14550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2N74_RS14555	COG1116	anion transmembrane transporter activity
H2N74_RS14560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2N74_RS14565	COG0494	nUDIX hydrolase
H2N74_RS14570	COG4824	toxin secretion phage lysis holin
H2N74_RS14575	COG0783	Belongs to the Dps family
H2N74_RS14600	COG0288	reversible hydration of carbon dioxide
H2N74_RS14610	COG1271	oxidase subunit
H2N74_RS14615	COG1294	oxidase, subunit
H2N74_RS14625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2N74_RS14630	COG1321	iron dependent repressor
H2N74_RS14630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2N74_RS14635	COG1121	(ABC) transporter
H2N74_RS14640	COG0803	Belongs to the bacterial solute-binding protein 9 family
H2N74_RS14645	COG4948	Mandelate Racemase Muconate Lactonizing
H2N74_RS14655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H2N74_RS14660	COG0596	Alpha beta hydrolase
H2N74_RS14670	COG1169	isochorismate synthase
H2N74_RS14675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2N74_RS14680	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H2N74_RS14810	COG3859	Proton-coupled thiamine transporter YuaJ
H2N74_RS14815	COG2268	Band 7 protein
H2N74_RS14820	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2N74_RS14825	COG2318	DinB family
H2N74_RS14835	COG1454	alcohol dehydrogenase
H2N74_RS14840	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS14845	COG1510	regulation of RNA biosynthetic process
H2N74_RS14855	COG0569	domain protein
H2N74_RS14860	COG1705	Flagellar rod assembly protein muramidase FlgJ
H2N74_RS14865	COG1017	nitric oxide dioxygenase activity
H2N74_RS14865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2N74_RS14890	COG0628	permease
H2N74_RS14895	COG0673	inositol 2-dehydrogenase activity
H2N74_RS14900	COG0693	protein deglycase activity
H2N74_RS14905	COG0840	transmembrane signaling receptor activity
H2N74_RS14910	COG0840	transmembrane signaling receptor activity
H2N74_RS14915	COG0840	transmembrane signaling receptor activity
H2N74_RS14920	COG0840	transmembrane signaling receptor activity
H2N74_RS14935	COG2070	2-Nitropropane dioxygenase
H2N74_RS14940	COG0432	Pfam Uncharacterised protein family UPF0047
H2N74_RS14945	COG0366	Alpha amylase catalytic
H2N74_RS14950	COG1253	flavin adenine dinucleotide binding
H2N74_RS14955	COG2738	Putative neutral zinc metallopeptidase
H2N74_RS14970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2N74_RS14995	COG1335	isochorismatase
H2N74_RS15000	COG1979	alcohol dehydrogenase
H2N74_RS15005	COG1979	alcohol dehydrogenase
H2N74_RS15010	COG2155	Conserved Protein
H2N74_RS15015	COG1098	S1 RNA binding domain
H2N74_RS15020	COG0436	Aminotransferase
H2N74_RS15025	COG1522	sequence-specific DNA binding
H2N74_RS15030	COG2267	carboxylic ester hydrolase activity
H2N74_RS15045	COG2205	protein histidine kinase activity
H2N74_RS15055	COG5018	Exonuclease
H2N74_RS15060	COG2814	Major facilitator Superfamily
H2N74_RS15065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2N74_RS15070	COG3011	Protein conserved in bacteria
H2N74_RS15080	COG3290	protein histidine kinase activity
H2N74_RS15085	COG4565	transcriptional regulatory protein
H2N74_RS15115	COG2111	Na H antiporter
H2N74_RS15115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2N74_RS15120	COG2111	Na H antiporter
H2N74_RS15125	COG1006	Multisubunit Na H antiporter MnhC subunit
H2N74_RS15130	COG0651	ATP synthesis coupled electron transport
H2N74_RS15135	COG1863	multisubunit Na H antiporter MnhE subunit
H2N74_RS15140	COG2212	antiporter activity
H2N74_RS15145	COG1320	monovalent cation:proton antiporter activity
H2N74_RS15150	COG2050	protein possibly involved in aromatic compounds catabolism
H2N74_RS15155	COG2197	response regulator
H2N74_RS15160	COG4585	Histidine kinase
H2N74_RS15165	COG0142	geranyltranstransferase activity
H2N74_RS15180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H2N74_RS15185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H2N74_RS15190	COG1335	isochorismatase
H2N74_RS15195	COG5506	Protein of unknown function (DUF1694)
H2N74_RS15210	COG0628	permease
H2N74_RS15220	COG1418	mRNA catabolic process
H2N74_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS15235	COG1511	domain protein
H2N74_RS15240	COG0433	COG0433 Predicted ATPase
H2N74_RS15240	COG1674	ftsk spoiiie
H2N74_RS15245	COG4499	WXG100 protein secretion system (Wss), protein YukC
H2N74_RS15250	COG5417	Belongs to the EsaB family
H2N74_RS15255	COG4842	Belongs to the WXG100 family
H2N74_RS15260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H2N74_RS15260	COG2508	Transcriptional regulator
H2N74_RS15265	COG0686	Belongs to the AlaDH PNT family
H2N74_RS15270	COG5634	Uncharacterized conserved protein (DUF2278)
H2N74_RS15275	COG3251	PFAM MbtH domain protein
H2N74_RS15280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2N74_RS15285	COG1535	isochorismatase
H2N74_RS15285	COG3433	isochorismatase activity
H2N74_RS15290	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2N74_RS15295	COG1169	isochorismate synthase
H2N74_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS15305	COG2819	hydrolase of the alpha beta superfamily
H2N74_RS15310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H2N74_RS15315	COG1268	BioY protein
H2N74_RS15320	COG2056	Na+-H+ antiporter family
H2N74_RS15330	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H2N74_RS15335	COG3584	3D domain protein
H2N74_RS15350	COG1252	NADH dehydrogenase
H2N74_RS15400	COG1131	(ABC) transporter
H2N74_RS15420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2N74_RS15425	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H2N74_RS15440	COG0316	Belongs to the HesB IscA family
H2N74_RS15450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2N74_RS15460	COG1252	NADH dehydrogenase
H2N74_RS15465	COG4837	Protein of unknown function (DUF1462)
H2N74_RS15470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H2N74_RS15475	COG1506	peptidase
H2N74_RS15475	COG4946	Tricorn protease homolog
H2N74_RS15475	COG0823	Involved in the tonB-independent uptake of proteins
H2N74_RS15490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2N74_RS15495	COG0460	homoserine dehydrogenase
H2N74_RS15500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2N74_RS15505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2N74_RS15510	COG0647	UMP catabolic process
H2N74_RS15515	COG2445	Protein of unknown function DUF86
H2N74_RS15520	COG4470	Protein conserved in bacteria
H2N74_RS15530	COG0739	heme binding
H2N74_RS15540	COG0737	Belongs to the 5'-nucleotidase family
H2N74_RS15545	COG0730	response to heat
H2N74_RS15550	COG1801	Protein of unknown function DUF72
H2N74_RS15565	COG2508	Transcriptional regulator
H2N74_RS15570	COG0457	Tetratricopeptide repeat
H2N74_RS15580	COG2814	Major facilitator Superfamily
H2N74_RS15585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2N74_RS15590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2N74_RS15595	COG2356	endonuclease I
H2N74_RS15600	COG3842	ATPase activity
H2N74_RS15605	COG2188	Transcriptional regulator
H2N74_RS15610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2N74_RS15615	COG0395	ABC-type sugar transport system, permease component
H2N74_RS15620	COG1175	transmembrane transport
H2N74_RS15625	COG1653	transport
H2N74_RS15630	COG2222	sugar isomerase
H2N74_RS15635	COG0789	Transcriptional regulator
H2N74_RS15660	COG0322	excinuclease ABC activity
H2N74_RS15665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2N74_RS15670	COG2226	methyltransferase
H2N74_RS15680	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS15685	COG0719	Fe-S assembly protein
H2N74_RS15690	COG0822	iron-sulfur transferase activity
H2N74_RS15695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2N74_RS15700	COG0719	Fe-S assembly protein
H2N74_RS15705	COG0396	ATPase activity
H2N74_RS15715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2N74_RS15720	COG1464	Belongs to the NlpA lipoprotein family
H2N74_RS15725	COG2011	ABC-type metal ion transport system permease component
H2N74_RS15730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2N74_RS15740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS15745	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H2N74_RS15760	COG1393	Belongs to the ArsC family
H2N74_RS15765	COG1960	acyl-CoA dehydrogenase activity
H2N74_RS15770	COG0183	Belongs to the thiolase family
H2N74_RS15775	COG1024	Enoyl-CoA hydratase
H2N74_RS15775	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2N74_RS15795	COG5577	PFAM Coat F domain
H2N74_RS15800	COG1846	Transcriptional regulator
H2N74_RS15805	COG0477	Major facilitator Superfamily
H2N74_RS15810	COG0583	DNA-binding transcription factor activity
H2N74_RS15830	COG1120	ATPase activity
H2N74_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS15850	COG0783	Belongs to the Dps family
H2N74_RS15855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2N74_RS15860	COG0745	RESPONSE REGULATOR receiver
H2N74_RS15865	COG2205	protein histidine kinase activity
H2N74_RS15865	COG2770	Histidine kinase
H2N74_RS15875	COG1309	transcriptional regulator
H2N74_RS15880	COG0114	fumarate hydratase activity
H2N74_RS15890	COG0697	spore germination
H2N74_RS15895	COG0814	amino acid
H2N74_RS15905	COG2197	response regulator
H2N74_RS15910	COG4585	Histidine kinase
H2N74_RS15915	COG4758	membrane
H2N74_RS15920	COG3595	metallopeptidase activity
H2N74_RS15925	COG1842	Phage shock protein A
H2N74_RS15930	COG4758	membrane
H2N74_RS15935	COG2814	Major facilitator Superfamily
H2N74_RS15940	COG2096	Adenosyltransferase
H2N74_RS15945	COG1120	ATPase activity
H2N74_RS15950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS15955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2N74_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS15965	COG3386	PFAM SMP-30 Gluconolaconase
H2N74_RS15970	COG2205	protein histidine kinase activity
H2N74_RS15975	COG0745	RESPONSE REGULATOR receiver
H2N74_RS15985	COG1191	sigma factor activity
H2N74_RS15995	COG2140	Oxalate decarboxylase
H2N74_RS16010	COG1120	ATPase activity
H2N74_RS16015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS16020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS16025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2N74_RS16055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS16060	COG0509	glycine decarboxylation via glycine cleavage system
H2N74_RS16065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2N74_RS16085	COG0492	ferredoxin-NADP+ reductase activity
H2N74_RS16090	COG3118	belongs to the thioredoxin family
H2N74_RS16100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2N74_RS16120	COG1309	transcriptional regulator
H2N74_RS16125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2N74_RS16130	COG0531	amino acid
H2N74_RS16140	COG1988	membrane-bound metal-dependent
H2N74_RS16145	COG1368	sulfuric ester hydrolase activity
H2N74_RS16150	COG1910	domain protein
H2N74_RS16155	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2N74_RS16160	COG4149	molybdate abc transporter
H2N74_RS16165	COG2197	response regulator
H2N74_RS16170	COG3850	Histidine kinase
H2N74_RS16175	COG1131	(ABC) transporter
H2N74_RS16185	COG0842	Transport permease protein
H2N74_RS16190	COG0656	L-ascorbic acid biosynthetic process
H2N74_RS16210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2N74_RS16215	COG3973	AAA domain
H2N74_RS16220	COG2860	membrane
H2N74_RS16230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H2N74_RS16235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2N74_RS16240	COG2217	Heavy metal translocating P-type atpase
H2N74_RS16245	COG2217	Heavy metal translocating P-type atpase
H2N74_RS16250	COG2608	mercury ion transmembrane transporter activity
H2N74_RS16255	COG1937	Protein conserved in bacteria
H2N74_RS16260	COG0673	inositol 2-dehydrogenase activity
H2N74_RS16270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS16275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2N74_RS16280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS16285	COG1126	abc transporter atp-binding protein
H2N74_RS16290	COG0765	amino acid transport
H2N74_RS16295	COG0765	amino acid transport
H2N74_RS16300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS16305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2N74_RS16310	COG0454	-acetyltransferase
H2N74_RS16315	COG0583	DNA-binding transcription factor activity
H2N74_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS16325	COG2732	(Barnase) inhibitor
H2N74_RS16330	COG2732	(Barnase) inhibitor
H2N74_RS16345	COG0557	exoribonuclease II activity
H2N74_RS16350	COG1647	Serine aminopeptidase, S33
H2N74_RS16355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H2N74_RS16360	COG1476	TRANSCRIPTIONal
H2N74_RS16365	COG1396	sequence-specific DNA binding
H2N74_RS16370	COG1396	sequence-specific DNA binding
H2N74_RS16375	COG1733	regulation of RNA biosynthetic process
H2N74_RS16400	COG1131	(ABC) transporter
H2N74_RS16405	COG1174	glycine betaine transport
H2N74_RS16410	COG1732	Glycine betaine
H2N74_RS16415	COG1174	glycine betaine transport
H2N74_RS16420	COG0517	IMP dehydrogenase activity
H2N74_RS16420	COG1125	glycine betaine transport
H2N74_RS16425	COG1510	regulation of RNA biosynthetic process
H2N74_RS16430	COG1174	glycine betaine transport
H2N74_RS16435	COG1732	Glycine betaine
H2N74_RS16440	COG1174	glycine betaine transport
H2N74_RS16445	COG1125	glycine betaine transport
H2N74_RS16445	COG0517	IMP dehydrogenase activity
H2N74_RS16450	COG1510	regulation of RNA biosynthetic process
H2N74_RS16455	COG2095	MarC family integral membrane protein
H2N74_RS16460	COG3064	Membrane
H2N74_RS16465	COG4640	response to antibiotic
H2N74_RS16470	COG0456	acetyltransferase
H2N74_RS16490	COG0126	phosphoglycerate kinase activity
H2N74_RS16495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2N74_RS16500	COG2390	Transcriptional regulator
H2N74_RS16505	COG2814	Major facilitator Superfamily
H2N74_RS16510	COG1609	Transcriptional regulator
H2N74_RS16515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS16520	COG0583	DNA-binding transcription factor activity
H2N74_RS16525	COG0697	spore germination
H2N74_RS16530	COG1113	amino acid transport
H2N74_RS16540	COG1737	Transcriptional regulator
H2N74_RS16545	COG1070	Carbohydrate kinase
H2N74_RS16570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS16575	COG2186	Transcriptional regulator
H2N74_RS16580	COG1620	l-lactate permease
H2N74_RS16585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H2N74_RS16595	COG5039	Polysaccharide pyruvyl transferase
H2N74_RS16600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2N74_RS16605	COG0110	maltose O-acetyltransferase activity
H2N74_RS16610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2N74_RS16615	COG2244	polysaccharide biosynthetic process
H2N74_RS16620	COG1216	Glycosyl transferase, family 2
H2N74_RS16625	COG5039	Polysaccharide pyruvyl transferase
H2N74_RS16630	COG1216	Glycosyl transferase, family 2
H2N74_RS16640	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS16645	COG1215	transferase activity, transferring glycosyl groups
H2N74_RS16650	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS16655	COG1086	Polysaccharide biosynthesis protein
H2N74_RS16660	COG0489	protein tyrosine kinase activity
H2N74_RS16665	COG3944	biosynthesis protein
H2N74_RS16670	COG1396	sequence-specific DNA binding
H2N74_RS16675	COG2272	Belongs to the type-B carboxylesterase lipase family
H2N74_RS16685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H2N74_RS16690	COG2364	Membrane
H2N74_RS16695	COG0456	acetyltransferase
H2N74_RS16700	COG3479	Phenolic acid decarboxylase
H2N74_RS16740	COG2223	nitrite transmembrane transporter activity
H2N74_RS16745	COG1609	Transcriptional regulator
H2N74_RS16755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2N74_RS16760	COG0366	Alpha amylase catalytic
H2N74_RS16765	COG1554	hydrolase, family 65, central catalytic
H2N74_RS16770	COG5521	maltodextrose utilization protein MalA
H2N74_RS16775	COG3833	ABC-type maltose transport systems, permease component
H2N74_RS16780	COG1175	transmembrane transport
H2N74_RS16785	COG2182	Extracellular solute-binding protein
H2N74_RS16790	COG0366	Alpha amylase catalytic
H2N74_RS16795	COG1609	Transcriptional regulator
H2N74_RS16800	COG1611	Belongs to the LOG family
H2N74_RS16805	COG1694	Mazg nucleotide pyrophosphohydrolase
H2N74_RS16810	COG0659	secondary active sulfate transmembrane transporter activity
H2N74_RS16815	COG0288	reversible hydration of carbon dioxide
H2N74_RS16820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2N74_RS16825	COG4290	ribonuclease
H2N74_RS16830	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H2N74_RS16835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS16845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H2N74_RS16855	COG1051	belongs to the nudix hydrolase family
H2N74_RS16860	COG0492	ferredoxin-NADP+ reductase activity
H2N74_RS16865	COG3883	PFAM NLP P60 protein
H2N74_RS16865	COG0791	NLP P60 protein
H2N74_RS16870	COG0457	Tetratricopeptide repeat
H2N74_RS16875	COG5002	protein histidine kinase activity
H2N74_RS16880	COG0745	RESPONSE REGULATOR receiver
H2N74_RS16890	COG1132	(ABC) transporter
H2N74_RS16895	COG0140	phosphoribosyl-ATP diphosphatase activity
H2N74_RS16895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2N74_RS16920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2N74_RS16935	COG4990	cell redox homeostasis
H2N74_RS16940	COG0110	maltose O-acetyltransferase activity
H2N74_RS16960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H2N74_RS16970	COG2188	Transcriptional regulator
H2N74_RS16975	COG1309	transcriptional regulator
H2N74_RS16980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2N74_RS16985	COG1950	PFAM Membrane protein of
H2N74_RS16990	COG1983	PspC domain protein
H2N74_RS16995	COG3595	metallopeptidase activity
H2N74_RS17010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2N74_RS17020	COG4897	Protein conserved in bacteria
H2N74_RS17025	COG3848	Pyruvate phosphate dikinase
H2N74_RS17025	COG0574	Belongs to the PEP-utilizing enzyme family
H2N74_RS17030	COG1309	transcriptional regulator
H2N74_RS17035	COG2814	Major facilitator Superfamily
H2N74_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS17080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2N74_RS17090	COG3409	Peptidoglycan-binding domain 1 protein
H2N74_RS17090	COG0793	Belongs to the peptidase S41A family
H2N74_RS17095	COG3420	alginic acid biosynthetic process
H2N74_RS17100	COG2177	Part of the ABC transporter FtsEX involved in
H2N74_RS17105	COG2884	Cell division ATP-binding protein ftsE
H2N74_RS17110	COG2010	Cytochrome c
H2N74_RS17115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS17130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H2N74_RS17145	COG1516	flagellar protein fliS
H2N74_RS17150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H2N74_RS17155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H2N74_RS17175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H2N74_RS17180	COG4786	Flagellar basal body rod
H2N74_RS17180	COG1256	bacterial-type flagellum assembly
H2N74_RS17185	COG3418	PFAM FlgN family protein
H2N74_RS17190	COG2747	anti-sigma28 factor FlgM
H2N74_RS17200	COG1040	competence protein
H2N74_RS17210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H2N74_RS17215	COG1307	EDD domain protein, DegV family
H2N74_RS17220	COG2197	response regulator
H2N74_RS17225	COG4585	Histidine kinase
H2N74_RS17230	COG1739	Uncharacterized protein family UPF0029
H2N74_RS17235	COG1316	TRANSCRIPTIONal
H2N74_RS17240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2N74_RS17245	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS17250	COG1215	transferase activity, transferring glycosyl groups
H2N74_RS17255	COG3206	protein involved in exopolysaccharide biosynthesis
H2N74_RS17260	COG3307	-O-antigen
H2N74_RS17265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2N74_RS17270	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS17270	COG0297	glycogen (starch) synthase activity
H2N74_RS17275	COG2244	polysaccharide biosynthetic process
H2N74_RS17285	COG2247	cell wall binding repeat
H2N74_RS17285	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2N74_RS17290	COG2247	cell wall binding repeat
H2N74_RS17290	COG2385	sporulation resulting in formation of a cellular spore
H2N74_RS17300	COG1316	TRANSCRIPTIONal
H2N74_RS17305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H2N74_RS17310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2N74_RS17315	COG1134	teichoic acid transport
H2N74_RS17320	COG1682	transport, permease protein
H2N74_RS17325	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2N74_RS17330	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS17335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2N74_RS17340	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H2N74_RS17345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2N74_RS17350	COG4193	domain, Protein
H2N74_RS17355	COG1482	cell wall glycoprotein biosynthetic process
H2N74_RS17360	COG0697	spore germination
H2N74_RS17365	COG0814	amino acid
H2N74_RS17375	COG1215	transferase activity, transferring glycosyl groups
H2N74_RS17380	COG2814	Major facilitator Superfamily
H2N74_RS17385	COG1316	TRANSCRIPTIONal
H2N74_RS17390	COG0561	phosphatase activity
H2N74_RS17395	COG2433	Pfam Transposase IS66
H2N74_RS17400	COG0791	NLP P60 protein
H2N74_RS17410	COG2843	Capsule synthesis protein
H2N74_RS17420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2N74_RS17425	COG0697	spore germination
H2N74_RS17430	COG0814	amino acid
H2N74_RS17440	COG1609	Transcriptional regulator
H2N74_RS17445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2N74_RS17455	COG1129	ABC transporter
H2N74_RS17460	COG1172	Belongs to the binding-protein-dependent transport system permease family
H2N74_RS17465	COG1879	ABC-type sugar transport system periplasmic component
H2N74_RS17470	COG3103	Sh3 type 3 domain protein
H2N74_RS17475	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2N74_RS17480	COG3527	Alpha-acetolactate decarboxylase
H2N74_RS17485	COG0028	Belongs to the TPP enzyme family
H2N74_RS17490	COG0583	DNA-binding transcription factor activity
H2N74_RS17495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H2N74_RS17510	COG5337	Spore coat protein CotH
H2N74_RS17520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2N74_RS17530	COG0405	Gamma-glutamyltransferase
H2N74_RS17535	COG1522	sequence-specific DNA binding
H2N74_RS17540	COG2059	Chromate
H2N74_RS17545	COG2059	Chromate
H2N74_RS17555	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2N74_RS17560	COG0583	DNA-binding transcription factor activity
H2N74_RS17570	COG2849	repeat protein
H2N74_RS17575	COG5444	nuclease activity
H2N74_RS17590	COG3878	Protein conserved in bacteria
H2N74_RS17595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2N74_RS17600	COG4464	protein tyrosine phosphatase activity
H2N74_RS17605	COG0489	protein tyrosine kinase activity
H2N74_RS17610	COG3944	biosynthesis protein
H2N74_RS17620	COG4715	Zinc finger, swim domain protein
H2N74_RS17625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2N74_RS17630	COG0561	phosphatase activity
H2N74_RS17635	COG1349	DNA-binding transcription factor activity
H2N74_RS17640	COG0629	single-stranded DNA binding
H2N74_RS17665	COG0457	Tetratricopeptide repeat
H2N74_RS17670	COG4786	Flagellar basal body rod
H2N74_RS17675	COG4786	Flagellar basal body rod
H2N74_RS17680	COG1077	Cell shape determining protein MreB Mrl
H2N74_RS17685	COG1609	Transcriptional regulator
H2N74_RS17690	COG1846	Transcriptional regulator
H2N74_RS17695	COG2814	Major facilitator Superfamily
H2N74_RS17700	COG1953	Uracil, thiamine, allantoin
H2N74_RS17705	COG0477	Major facilitator Superfamily
H2N74_RS17710	COG1335	isochorismatase
H2N74_RS17715	COG0004	ammonium transporteR
H2N74_RS17720	COG0347	Belongs to the P(II) protein family
H2N74_RS17725	COG0772	Belongs to the SEDS family
H2N74_RS17730	COG0671	phosphoesterase, PA-phosphatase related
H2N74_RS17740	COG0739	heme binding
H2N74_RS17745	COG1247	-acetyltransferase
H2N74_RS17760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2N74_RS17770	COG0726	polysaccharide deacetylase
H2N74_RS17775	COG1959	2 iron, 2 sulfur cluster binding
H2N74_RS17790	COG0831	urea catabolic process
H2N74_RS17800	COG1994	Peptidase M50
H2N74_RS17805	COG0457	Tetratricopeptide repeat
H2N74_RS17815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2N74_RS17825	COG2304	oxidoreductase activity
H2N74_RS17830	COG2304	oxidoreductase activity
H2N74_RS17835	COG2385	sporulation resulting in formation of a cellular spore
H2N74_RS17840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2N74_RS17850	COG4836	Membrane
H2N74_RS17920	COG0698	ribose 5-phosphate isomerase
H2N74_RS17925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2N74_RS17935	COG0009	L-threonylcarbamoyladenylate synthase
H2N74_RS17940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2N74_RS17960	COG2890	protein-(glutamine-N5) methyltransferase activity
H2N74_RS17965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2N74_RS17970	COG0346	lactoylglutathione lyase activity
H2N74_RS17975	COG0789	Transcriptional regulator
H2N74_RS17980	COG0679	Auxin Efflux Carrier
H2N74_RS17985	COG0281	malic enzyme
H2N74_RS18000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H2N74_RS18005	COG1494	fructose-1,6-bisphosphatase
H2N74_RS18010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2N74_RS18020	COG0191	fructose-bisphosphate aldolase activity
H2N74_RS18025	COG2204	response regulator
H2N74_RS18030	COG4821	SIS domain
H2N74_RS18045	COG2181	nitrate reductase activity
H2N74_RS18045	COG0247	lactate metabolic process
H2N74_RS18050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2N74_RS18065	COG1132	(ABC) transporter
H2N74_RS18070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2N74_RS18080	COG2181	nitrate reductase activity
H2N74_RS18085	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H2N74_RS18090	COG1140	nitrate reductase beta subunit
H2N74_RS18095	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H2N74_RS18100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2N74_RS18110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2N74_RS18115	COG2223	nitrite transmembrane transporter activity
H2N74_RS18125	COG4506	Protein conserved in bacteria
H2N74_RS18130	COG0457	Tetratricopeptide repeat
H2N74_RS18170	COG0010	Belongs to the arginase family
H2N74_RS18175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2N74_RS18180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2N74_RS18195	COG1994	Peptidase M50
H2N74_RS18200	COG1942	4-Oxalocrotonate Tautomerase
H2N74_RS18205	COG1846	Transcriptional regulator
H2N74_RS18215	COG0531	amino acid
H2N74_RS18220	COG3465	dGTPase activity
H2N74_RS18225	COG1078	dGTPase activity
H2N74_RS18240	COG1695	Transcriptional regulator
H2N74_RS18250	COG1131	(ABC) transporter
H2N74_RS18255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H2N74_RS18285	COG0583	DNA-binding transcription factor activity
H2N74_RS18290	COG2855	membrane
H2N74_RS18295	COG0280	phosphate acetyltransferase
H2N74_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS18310	COG0436	Aminotransferase
H2N74_RS18340	COG2814	Major facilitator Superfamily
H2N74_RS18345	COG2814	Major facilitator Superfamily
H2N74_RS18350	COG0833	amino acid
H2N74_RS18355	COG4187	Peptidase family M20/M25/M40
H2N74_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS18365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2N74_RS18370	COG2205	protein histidine kinase activity
H2N74_RS18375	COG0745	RESPONSE REGULATOR receiver
H2N74_RS18390	COG1131	(ABC) transporter
H2N74_RS18395	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H2N74_RS18400	COG1091	dTDP-4-dehydrorhamnose reductase activity
H2N74_RS18405	COG1088	dTDP-glucose 4,6-dehydratase activity
H2N74_RS18410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2N74_RS18415	COG3980	spore coat polysaccharide biosynthesis protein
H2N74_RS18420	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H2N74_RS18425	COG2089	acid synthase
H2N74_RS18430	COG0456	acetyltransferase
H2N74_RS18435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2N74_RS18440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H2N74_RS18445	COG0463	Glycosyl transferase, family 2
H2N74_RS18455	COG2363	Small membrane protein
H2N74_RS18460	COG2233	PERMEase
H2N74_RS18475	COG1216	Glycosyl transferase, family 2
H2N74_RS18490	COG1695	Transcriptional regulator
H2N74_RS18495	COG0351	phosphomethylpyrimidine kinase
H2N74_RS18505	COG1621	beta-fructofuranosidase activity
H2N74_RS18510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H2N74_RS18510	COG1263	PTS System
H2N74_RS18515	COG3711	transcriptional antiterminator
H2N74_RS18525	COG1404	Belongs to the peptidase S8 family
H2N74_RS18530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2N74_RS18540	COG0778	Nitroreductase
H2N74_RS18545	COG0772	Belongs to the SEDS family
H2N74_RS18550	COG0454	-acetyltransferase
H2N74_RS18570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2N74_RS18575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2N74_RS18580	COG2261	transglycosylase associated protein
H2N74_RS18585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H2N74_RS18590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H2N74_RS18595	COG2246	polysaccharide biosynthetic process
H2N74_RS18600	COG1309	transcriptional regulator
H2N74_RS18620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2N74_RS18625	COG2837	iron assimilation
H2N74_RS18630	COG2822	iron ion transport
H2N74_RS18645	COG0583	DNA-binding transcription factor activity
H2N74_RS18655	COG1346	cytolysis
H2N74_RS18660	COG4895	conserved protein (DUF2196)
H2N74_RS18665	COG0789	Transcriptional regulator
H2N74_RS18670	COG5504	Zn-dependent protease
H2N74_RS18675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2N74_RS18680	COG0346	lactoylglutathione lyase activity
H2N74_RS18685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS18690	COG1404	Belongs to the peptidase S8 family
H2N74_RS18695	COG1442	glycosyl transferase family 8
H2N74_RS18700	COG1846	Transcriptional regulator
H2N74_RS18705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2N74_RS18710	COG2357	RelA SpoT domain protein
H2N74_RS18715	COG1575	Belongs to the MenA family. Type 1 subfamily
H2N74_RS18730	COG1696	Membrane protein involved in D-alanine export
H2N74_RS18740	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H2N74_RS18745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2N74_RS18750	COG1486	melibiose metabolic process
H2N74_RS18755	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2N74_RS18760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS18765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS18770	COG3711	transcriptional antiterminator
H2N74_RS18770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2N74_RS18780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS18785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2N74_RS18795	COG0640	Transcriptional regulator
H2N74_RS18800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H2N74_RS18805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS18810	COG1447	Phosphotransferase system cellobiose-specific component IIA
H2N74_RS18815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H2N74_RS18820	COG2723	6-phospho-beta-galactosidase activity
H2N74_RS18825	COG1940	carbohydrate kinase activity
H2N74_RS18830	COG1482	cell wall glycoprotein biosynthetic process
H2N74_RS18840	COG0753	catalase activity
H2N74_RS18845	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H2N74_RS18850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2N74_RS18855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2N74_RS18860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H2N74_RS18865	COG4988	ABC transporter
H2N74_RS18870	COG1294	oxidase, subunit
H2N74_RS18875	COG1271	oxidase subunit
H2N74_RS18880	COG3493	citrate carrier protein
H2N74_RS18885	COG0726	polysaccharide deacetylase
H2N74_RS18890	COG3842	ATPase activity
H2N74_RS18895	COG2508	Transcriptional regulator
H2N74_RS18900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS18910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2N74_RS18925	COG4894	glucomannan catabolic process
H2N74_RS18930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2N74_RS18935	COG0500	methyltransferase
H2N74_RS18940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2N74_RS18955	COG0753	catalase activity
H2N74_RS18955	COG0693	protein deglycase activity
H2N74_RS18960	COG2851	Citrate transporter
H2N74_RS18965	COG2273	Hydrolase Family 16
H2N74_RS18970	COG3711	transcriptional antiterminator
H2N74_RS18975	COG2270	Major facilitator Superfamily
H2N74_RS18980	COG0513	Belongs to the DEAD box helicase family
H2N74_RS19035	COG0697	spore germination
H2N74_RS19040	COG0589	response to stress
H2N74_RS19130	COG0010	Belongs to the arginase family
H2N74_RS19135	COG0833	amino acid
H2N74_RS19140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H2N74_RS19145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H2N74_RS19155	COG2390	Transcriptional regulator
H2N74_RS19160	COG0561	phosphatase activity
H2N74_RS19190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H2N74_RS19195	COG5294	Protein conserved in bacteria
H2N74_RS19200	COG0577	efflux transmembrane transporter activity
H2N74_RS19205	COG1136	(ABC) transporter
H2N74_RS19210	COG2205	protein histidine kinase activity
H2N74_RS19215	COG0745	RESPONSE REGULATOR receiver
H2N74_RS19220	COG2205	protein histidine kinase activity
H2N74_RS19225	COG0745	RESPONSE REGULATOR receiver
H2N74_RS19255	COG1082	Xylose isomerase domain protein TIM barrel
H2N74_RS19265	COG2814	Major facilitator Superfamily
H2N74_RS19295	COG1349	DNA-binding transcription factor activity
H2N74_RS19300	COG0667	Aldo Keto reductase
H2N74_RS19305	COG2814	Major facilitator Superfamily
H2N74_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
H2N74_RS19320	COG2197	response regulator
H2N74_RS19325	COG4585	Histidine kinase
H2N74_RS19330	COG3239	Fatty acid desaturase
H2N74_RS19335	COG1309	transcriptional regulator
H2N74_RS19340	COG1012	belongs to the aldehyde dehydrogenase family
H2N74_RS19345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2N74_RS19355	COG0640	Transcriptional regulator
H2N74_RS19360	COG2814	Major facilitator Superfamily
H2N74_RS19365	COG1714	RDD family
H2N74_RS19375	COG0450	alkyl hydroperoxide reductase
H2N74_RS19380	COG3634	alkyl hydroperoxide reductase activity
H2N74_RS19385	COG3177	Filamentation induced by cAMP protein fic
H2N74_RS19390	COG1113	amino acid transport
H2N74_RS19400	COG2080	2 iron, 2 sulfur cluster binding
H2N74_RS19415	COG2068	MobA-Related Protein
H2N74_RS19420	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H2N74_RS19465	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H2N74_RS19470	COG0667	Aldo Keto reductase
H2N74_RS19475	COG0456	acetyltransferase
H2N74_RS19480	COG0457	Tetratricopeptide repeat
H2N74_RS19485	COG0010	Belongs to the arginase family
H2N74_RS19490	COG0833	amino acid
H2N74_RS19495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2N74_RS19500	COG5658	integral membrane protein
H2N74_RS19505	COG0640	Transcriptional regulator
H2N74_RS19510	COG3829	transcription factor binding
H2N74_RS19520	COG0488	(ABC) transporter
H2N74_RS19535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2N74_RS19540	COG3850	Histidine kinase
H2N74_RS19540	COG5002	protein histidine kinase activity
H2N74_RS19545	COG0745	RESPONSE REGULATOR receiver
H2N74_RS19555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2N74_RS19560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H2N74_RS19565	COG4853	Protein conserved in bacteria
H2N74_RS19570	COG4863	YycH protein
H2N74_RS19575	COG5002	protein histidine kinase activity
H2N74_RS19580	COG0745	RESPONSE REGULATOR receiver
H2N74_RS19610	COG0346	lactoylglutathione lyase activity
H2N74_RS19615	COG0305	Participates in initiation and elongation during chromosome replication
H2N74_RS19630	COG3093	addiction module antidote protein HigA
H2N74_RS19635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H2N74_RS19650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H2N74_RS19655	COG0438	transferase activity, transferring glycosyl groups
H2N74_RS19665	COG2112	serine threonine protein kinase
H2N74_RS19675	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H2N74_RS19680	COG4241	membrane
H2N74_RS19690	COG5577	PFAM Coat F domain
H2N74_RS19695	COG1733	regulation of RNA biosynthetic process
H2N74_RS19705	COG0697	spore germination
H2N74_RS19710	COG1621	beta-fructofuranosidase activity
H2N74_RS19715	COG1621	beta-fructofuranosidase activity
H2N74_RS19720	COG1802	Transcriptional regulator
H2N74_RS19725	COG2318	DinB family
H2N74_RS19730	COG2211	Major facilitator Superfamily
H2N74_RS19735	COG0697	spore germination
H2N74_RS19745	COG0778	Nitroreductase
H2N74_RS19750	COG1846	Transcriptional regulator
H2N74_RS19755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H2N74_RS19760	COG1846	Transcriptional regulator
H2N74_RS19765	COG2153	protein acetylation
H2N74_RS19775	COG0546	phosphoglycolate phosphatase activity
H2N74_RS19805	COG1404	Belongs to the peptidase S8 family
H2N74_RS19810	COG1331	Highly conserved protein containing a thioredoxin domain
H2N74_RS19815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2N74_RS19820	COG0697	spore germination
H2N74_RS19825	COG1078	dGTPase activity
H2N74_RS19835	COG1331	Highly conserved protein containing a thioredoxin domain
H2N74_RS19840	COG1266	CAAX protease self-immunity
H2N74_RS19845	COG0477	Major facilitator Superfamily
H2N74_RS19845	COG2814	Major facilitator Superfamily
H2N74_RS19850	COG0346	lactoylglutathione lyase activity
H2N74_RS19855	COG1609	Transcriptional regulator
H2N74_RS19860	COG0708	Exodeoxyribonuclease III
H2N74_RS19865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2N74_RS19870	COG2169	Transcriptional regulator
H2N74_RS19880	COG0629	single-stranded DNA binding
H2N74_RS19890	COG0012	GTP binding
H2N74_RS19895	COG0243	molybdopterin cofactor binding
H2N74_RS19900	COG4481	Protein conserved in bacteria
H2N74_RS19905	COG3949	Membrane
H2N74_RS19920	COG1475	DNA binding
H2N74_RS19925	COG1192	Involved in chromosome partitioning
H2N74_RS19950	COG1847	R3H domain protein
H2N74_RS19955	COG0706	membrane insertase activity