locus-tag class description HUO02_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUO02_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUO02_RS00015 ENOG410848D S4 domain protein YaaA HUO02_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUO02_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUO02_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUO02_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUO02_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUO02_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUO02_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUO02_RS00095 ENOG4105BZW Glycerate kinase HUO02_RS00105 ENOG4105ZMH deoxynucleoside kinase HUO02_RS00115 ENOG4105VRS hydrolase family 18 HUO02_RS00120 ENOG4105GTG Isochorismatase HUO02_RS00125 ENOG4108Z6B deaminase HUO02_RS00135 ENOG4105C6E dna polymerase iii HUO02_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUO02_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUO02_RS00155 ENOG41067KS pro-sigma K processing HUO02_RS00195 ENOG4105CDW Resistance protein HUO02_RS00200 ENOG4105CXN decarboxylase HUO02_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUO02_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II HUO02_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) HUO02_RS00220 ENOG4105FA2 dna polymerase iii HUO02_RS00225 ENOG4105MA4 psp1 domain protein HUO02_RS00235 ENOG41060K3 Methyltransferase HUO02_RS00240 ENOG4105VC4 domain protein HUO02_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HUO02_RS00250 ENOG4105KRN Transcriptional regulator, abrb family HUO02_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUO02_RS00260 ENOG4105F8V Hydrolase, tatD family HUO02_RS00265 ENOG41069ER domain protein HUO02_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUO02_RS00280 ENOG4105XFA sporulation peptidase YabG HUO02_RS00285 ENOG4105W42 Veg protein HUO02_RS00290 ENOG4105XEW small acid-soluble spore protein HUO02_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUO02_RS00300 ENOG4105DFT pur operon repressor HUO02_RS00305 ENOG4105KME endoribonuclease L-psp HUO02_RS00310 ENOG4105K4W Could be involved in septation (By similarity) HUO02_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUO02_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUO02_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUO02_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor HUO02_RS00345 ENOG4108M14 stage v sporulation protein t HUO02_RS00355 ENOG4108IY2 MazG family HUO02_RS00360 ENOG41082I2 s4 domain protein HUO02_RS00365 ENOG4105VYY sporulation protein yabp HUO02_RS00380 ENOG41060GV RNA binding s1 domain protein HUO02_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUO02_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUO02_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUO02_RS00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUO02_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HUO02_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HUO02_RS00440 ENOG4105C6T cysteine synthase HUO02_RS00445 ENOG4105CRQ synthase (Component I) HUO02_RS00450 ENOG4105DDQ anthranilate synthase HUO02_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HUO02_RS00460 ENOG4105EEI dihydropteroate synthase HUO02_RS00465 ENOG4105KRF dihydroneopterin aldolase HUO02_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUO02_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HUO02_RS00485 ENOG4105CRK lysyL-tRNA synthetase HUO02_RS00570 ENOG4108Z0C Uvrb UvrC protein HUO02_RS00575 ENOG41066A3 ATP guanido phosphotransferase HUO02_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUO02_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUO02_RS00595 ENOG4105CTP PilT protein domain protein HUO02_RS00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUO02_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUO02_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUO02_RS00615 ENOG4105D7W serine acetyltransferase HUO02_RS00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HUO02_RS00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUO02_RS00635 ENOG4105M0M Tetracycline resistance protein HUO02_RS00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUO02_RS00670 ENOG4108VZM 50s ribosomal protein L10 HUO02_RS00680 ENOG4107Y49 methyltransferase HUO02_RS00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUO02_RS00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUO02_RS00695 ENOG4105XPM ribosomal protein HUO02_RS00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUO02_RS00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUO02_RS00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUO02_RS00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUO02_RS00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HUO02_RS00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUO02_RS00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUO02_RS00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUO02_RS00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUO02_RS00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUO02_RS00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUO02_RS00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUO02_RS00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUO02_RS00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUO02_RS00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUO02_RS00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUO02_RS00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUO02_RS00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUO02_RS00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUO02_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUO02_RS00850 ENOG41067V7 50S ribosomal protein L36 HUO02_RS00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUO02_RS00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUO02_RS00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUO02_RS00870 ENOG4108ZT0 50S ribosomal protein l17 HUO02_RS00875 ENOG4108JJB ABC transporter HUO02_RS00880 ENOG4108JJB ABC transporter HUO02_RS00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HUO02_RS00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUO02_RS00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUO02_RS00900 ENOG4108UJD 30S ribosomal protein S9 HUO02_RS00905 ENOG4108I0C methyltransferase HUO02_RS00925 ENOG4105D1F ATP-binding protein HUO02_RS00940 ENOG4108NMV polysaccharide deacetylase HUO02_RS01005 ENOG4108JPW Aminotransferase HUO02_RS01015 ENOG4105CPQ Dehydrogenase HUO02_RS01020 ENOG4105CHH sulfate transporter HUO02_RS01030 ENOG4108SA1 esterase HUO02_RS01050 ENOG410874W AraC family transcriptional regulator HUO02_RS01055 ENOG4105EHZ conserved protein UCP016719 HUO02_RS01060 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUO02_RS01075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUO02_RS01085 ENOG4105EWC Purine nucleoside phosphorylase HUO02_RS01115 ENOG4105EMN RNA polymerase sigma factor HUO02_RS01125 ENOG4105C8B TIGR00159 family HUO02_RS01130 ENOG4107U5W ybbr family HUO02_RS01135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUO02_RS01170 ENOG4105EWM Histidine kinase HUO02_RS01180 ENOG4105C19 ABC transporter HUO02_RS01205 ENOG41067MG lrgb family HUO02_RS01215 ENOG41061AU MarR family Transcriptional regulator HUO02_RS01230 ENOG4105BZU Histidine kinase HUO02_RS01235 ENOG4105WH1 Two component transcriptional regulator luxr family HUO02_RS01240 ENOG4105CJ1 ABC, transporter HUO02_RS01265 ENOG4106DDH Sporulation-specific SASP protein HUO02_RS01280 ENOG4107QTZ amino acid HUO02_RS01295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HUO02_RS01300 ENOG4105CXY transporter HUO02_RS01335 ENOG4107SCQ Iron-containing alcohol dehydrogenase HUO02_RS01340 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUO02_RS01345 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HUO02_RS01350 ENOG4107ZTW SNARE associated Golgi HUO02_RS01365 ENOG4105C72 UPF0176 protein HUO02_RS01375 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUO02_RS01380 ENOG4108IQI permease HUO02_RS01385 ENOG4108J5H Homocysteine s-methyltransferase HUO02_RS01395 ENOG4105CSV Glutaminase HUO02_RS01425 ENOG41076HS cation diffusion facilitator family transporter HUO02_RS01430 ENOG4108TVJ Nitroreductase HUO02_RS01435 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HUO02_RS01440 ENOG4108VGI doxx family HUO02_RS01445 ENOG4105XXY Thioredoxin HUO02_RS01460 ENOG4105DGI Alkaline phosphatase HUO02_RS01465 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUO02_RS01470 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUO02_RS01475 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HUO02_RS01480 ENOG4107EPV Aminotransferase class V HUO02_RS01485 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUO02_RS01490 ENOG4105J7D transcriptional regulator HUO02_RS01495 ENOG4107RB3 L-asparaginase HUO02_RS01500 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HUO02_RS01505 ENOG41060AI SEC-C motif HUO02_RS01510 ENOG4107SET aldo keto reductase HUO02_RS01540 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUO02_RS01550 ENOG4105DSE periplasmic solute binding protein HUO02_RS01555 ENOG4105DIK (ABC) transporter HUO02_RS01565 ENOG4105DEN Luciferase family HUO02_RS01570 ENOG4108N0M stress protein HUO02_RS01575 ENOG4106FN3 tellurium resistance protein HUO02_RS01580 ENOG4106FN3 tellurium resistance protein HUO02_RS01585 ENOG4107TS3 membrane protein, TerC HUO02_RS01590 ENOG4108TTB tellurium resistance protein HUO02_RS01600 ENOG41079KZ Major Facilitator Superfamily HUO02_RS01605 ENOG4108IJ7 Glycine betaine HUO02_RS01610 ENOG4107SQ8 Glycine betaine HUO02_RS01640 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUO02_RS01670 ENOG4105EIG urea carboxylase-associated protein 1 HUO02_RS01675 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HUO02_RS01685 ENOG4105I1F Resistance protein HUO02_RS01690 ENOG4108WBH protein TIM barrel HUO02_RS01695 ENOG4105DJB Major Facilitator Superfamily HUO02_RS01700 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUO02_RS01705 ENOG4105I82 acetyl xylan esterase HUO02_RS01710 ENOG410756H nucleotidyltransferase HUO02_RS01720 ENOG4105C26 Dehydrogenase HUO02_RS01725 ENOG4105CK7 Sodium proline symporter HUO02_RS01730 ENOG4107YHD transcriptional regulator HUO02_RS01735 ENOG4105CAY ferredoxin--nadp reductase HUO02_RS01740 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUO02_RS01745 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HUO02_RS01750 ENOG4108IFG nitrite reductase, (NAD(P)H) HUO02_RS01755 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUO02_RS01770 ENOG4105CKI cobalamin synthesis protein HUO02_RS01775 ENOG4105E2A Dehydrogenase HUO02_RS01780 ENOG4105HHM rdd domain containing protein HUO02_RS01790 ENOG4105CS2 ec 3.2.1.21 HUO02_RS01805 ENOG41080HJ 6-phospho 3-hexuloisomerase HUO02_RS01810 ENOG4108VA3 3-hexulose-6-phosphate synthase HUO02_RS01815 ENOG4105KVH Transcriptional regulator HUO02_RS01820 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS01840 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUO02_RS01850 ENOG4105SX7 Transporter HUO02_RS01870 ENOG4105CDA abc transporter atp-binding protein HUO02_RS01875 ENOG4105DRP amino acid AbC transporter HUO02_RS01885 ENOG4106P55 Transcriptional regulator HUO02_RS01890 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUO02_RS01895 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUO02_RS01900 ENOG41069ZX HUO02_RS01905 ENOG41069ZX HUO02_RS01910 ENOG4105DUX Transporter HUO02_RS01925 ENOG4105E1K spore germination protein HUO02_RS01950 ENOG4105EAB amino acid AbC transporter HUO02_RS01955 ENOG4108HW4 amino acid AbC transporter HUO02_RS01970 ENOG4108PGP mmge prpd family protein HUO02_RS01980 ENOG4107WD8 ABC transporter, permease HUO02_RS01985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUO02_RS01990 ENOG4105BZU Histidine kinase HUO02_RS02010 ENOG4105CFH Aspartokinase HUO02_RS02015 ENOG4105DHS permease protein HUO02_RS02020 ENOG4105CM4 permease protein HUO02_RS02025 ENOG4108IPW abc transporter atp-binding protein HUO02_RS02040 ENOG4105R8C Transcriptional regulator HUO02_RS02045 ENOG4108DBC nitroreductase HUO02_RS02050 ENOG41067V3 Antibiotic biosynthesis monooxygenase HUO02_RS02055 ENOG4105YVS arsR family transcriptional regulator HUO02_RS02065 ENOG4108JPW Aminotransferase HUO02_RS02070 ENOG4105C26 Dehydrogenase HUO02_RS02080 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUO02_RS02085 ENOG4105KTB nuclear export factor GLE1 HUO02_RS02090 ENOG4108T5E Copper resistance protein HUO02_RS02095 ENOG4108ZYE Transcriptional regulator HUO02_RS02115 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HUO02_RS02135 ENOG4105E7W lamb ycsf family protein HUO02_RS02140 ENOG4105C5A transporter HUO02_RS02145 ENOG4105CFM UPF0317 protein HUO02_RS02150 ENOG4105P4J Allophanate hydrolase, subunit 1 HUO02_RS02160 ENOG4107258 Transcriptional regulator HUO02_RS02165 ENOG4105XJB lipolytic protein G-D-S-L family HUO02_RS02175 ENOG41061CK Antibiotic biosynthesis monooxygenase HUO02_RS02180 ENOG4107RVG penicillin-binding protein HUO02_RS02185 ENOG4107QM2 Aldo Keto reductase HUO02_RS02190 ENOG4105ETD TRANSCRIPTIONal HUO02_RS02200 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUO02_RS02215 ENOG410606W general stress protein HUO02_RS02225 ENOG4105VCH membrane HUO02_RS02235 ENOG4105C9U ATP-dependent DNA helicase RecQ HUO02_RS02250 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HUO02_RS02255 ENOG4107R8N Glycosyl transferase, family 2 HUO02_RS02265 ENOG4105C0X amino acid HUO02_RS02285 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HUO02_RS02325 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUO02_RS02335 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HUO02_RS02340 ENOG4105RXJ HUO02_RS02345 ENOG4105KPY Small multidrug resistance protein HUO02_RS02350 ENOG4105EU9 HUO02_RS02355 ENOG4105QVS general stress protein HUO02_RS02360 ENOG41082W1 Cupin 2, conserved barrel domain protein HUO02_RS02375 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HUO02_RS02380 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUO02_RS02385 ENOG4108MRH transcriptional regulatory protein HUO02_RS02390 ENOG4107QJT sodium dicarboxylate symporter HUO02_RS02395 ENOG4106F5Q Membrane HUO02_RS02400 ENOG4105CJ1 ABC, transporter HUO02_RS02415 ENOG4105FDT acyl-CoA dehydrogenase HUO02_RS02435 ENOG4105SZ6 Thioredoxin HUO02_RS02440 ENOG4105CPF Cell wall formation (By similarity) HUO02_RS02445 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HUO02_RS02450 ENOG4105C1J atp-dependent rna helicase HUO02_RS02455 ENOG410905X membrane-flanked domain protein HUO02_RS02460 ENOG4105CKV Membrane HUO02_RS02470 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUO02_RS02475 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HUO02_RS02480 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUO02_RS02490 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HUO02_RS02495 ENOG4107MMM Anti-sigma-factor antagonist HUO02_RS02500 ENOG4105FUA antagonist HUO02_RS02505 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUO02_RS02510 ENOG4107SGM protein serine threonine phosphatase HUO02_RS02515 ENOG4105WN5 stage II sporulation protein HUO02_RS02520 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUO02_RS02530 ENOG41064BQ Phosphatase HUO02_RS02545 ENOG410906U SprT-like HUO02_RS02590 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HUO02_RS02600 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HUO02_RS02620 ENOG4105C94 Transporter HUO02_RS02625 ENOG4105CSH Transporter HUO02_RS02630 ENOG4105K56 Transcriptional regulator HUO02_RS02640 ENOG4108ZMQ domain protein HUO02_RS02655 ENOG4108Z40 Transcriptional regulator HUO02_RS02660 ENOG4108RYK Nad-dependent epimerase dehydratase HUO02_RS02665 ENOG4105M4P Tetr family transcriptional regulator HUO02_RS02670 ENOG4105E1F short-chain dehydrogenase reductase HUO02_RS02675 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUO02_RS02680 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUO02_RS02690 ENOG4105ECK Fatty Acid Desaturase HUO02_RS02700 ENOG4105VEQ Cold shock protein HUO02_RS02705 ENOG4108VJ1 Transcriptional regulator (CarD family HUO02_RS02710 ENOG4105XTG Pfam:DUF156 HUO02_RS02715 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HUO02_RS02725 ENOG4105VFE sira family HUO02_RS02730 ENOG4107TPS domain protein HUO02_RS02735 ENOG4105VFE sira family HUO02_RS02740 ENOG41087NI Sulfite exporter TauE/SafE HUO02_RS02760 ENOG410645S MarR family Transcriptional regulator HUO02_RS02765 ENOG4105DCM major facilitator superfamily HUO02_RS02770 ENOG4105IRW patatin-like phospholipase family protein HUO02_RS02780 ENOG41082W1 Cupin 2, conserved barrel domain protein HUO02_RS02795 ENOG4105DNP FAD linked oxidase domain protein HUO02_RS02805 ENOG4105PGM cation diffusion facilitator family transporter HUO02_RS02810 ENOG4105H3G oxidoreductase HUO02_RS02820 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HUO02_RS02835 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUO02_RS02870 ENOG4105DWF phosphomethylpyrimidine kinase HUO02_RS02885 ENOG4105DQ4 alcohol dehydrogenase HUO02_RS02890 ENOG4105VUF Transcriptional regulator HUO02_RS02900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUO02_RS02930 ENOG4105EQ0 Major Facilitator superfamily HUO02_RS02935 ENOG4108JGH Tetr family transcriptional regulator HUO02_RS02940 ENOG4105T38 integral membrane protein HUO02_RS02945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUO02_RS02960 ENOG4105E2A Dehydrogenase HUO02_RS02965 ENOG4105PGS Spore coat protein HUO02_RS02975 ENOG4105ENE Histidine kinase HUO02_RS02980 ENOG4108VB1 regulatoR HUO02_RS02985 ENOG4105EYF MMPL domain protein HUO02_RS03005 ENOG4108JYZ YitT family HUO02_RS03015 ENOG4105C2C drug resistance transporter, Bcr CflA HUO02_RS03020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUO02_RS03040 ENOG41090E6 transcriptional regulator MERR family HUO02_RS03055 ENOG4105F2W methyltransferase HUO02_RS03065 ENOG4105DRR Transcriptional regulator, GntR family HUO02_RS03085 ENOG4105FQP Beta-lactamase HUO02_RS03095 ENOG41090UD (LipO)protein HUO02_RS03100 ENOG4108SUT Major Facilitator Superfamily HUO02_RS03105 ENOG4108TZY GntR Family Transcriptional Regulator HUO02_RS03110 ENOG4105JXH GntR family transcriptional regulator HUO02_RS03115 ENOG4105DJ2 Major Facilitator Superfamily HUO02_RS03135 ENOG4107QTZ amino acid HUO02_RS03155 ENOG4107QNK )-transporter HUO02_RS03195 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HUO02_RS03200 ENOG4105K8N protein family UPF0079, ATPase HUO02_RS03205 ENOG41072GX Peptidase M22 Glycoprotease HUO02_RS03210 ENOG410801F ribosomal-protein-alanine acetyltransferase HUO02_RS03215 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUO02_RS03220 ENOG4105C5H ABC transporter HUO02_RS03225 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUO02_RS03230 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUO02_RS03235 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUO02_RS03240 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUO02_RS03250 ENOG4108TYN CAAX amino terminal protease family protein HUO02_RS03260 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUO02_RS03265 ENOG4105ESF Peptidoglycan binding domain protein HUO02_RS03285 ENOG4105PGZ NB-ARC domain HUO02_RS03290 ENOG4105CPQ Dehydrogenase HUO02_RS03295 ENOG4105CT4 transporter HUO02_RS03310 ENOG41087YS Phage shock protein A HUO02_RS03315 ENOG4105DQX Zinc finger domain HUO02_RS03320 ENOG4108WV1 Pfam:DUF477 HUO02_RS03330 ENOG4105EXC Acyl-transferase HUO02_RS03335 ENOG4108P49 AntiSigma factor HUO02_RS03340 ENOG4105JVQ RNA Polymerase HUO02_RS03370 ENOG4107STQ Multicopper oxidase HUO02_RS03375 ENOG4105C85 amino acid HUO02_RS03385 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUO02_RS03400 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUO02_RS03415 ENOG4105C7N Xanthine uracil vitamin C permease HUO02_RS03440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HUO02_RS03445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HUO02_RS03450 ENOG4105C83 adenylosuccinate lyase HUO02_RS03455 ENOG4105C8V SAICAR synthetase HUO02_RS03460 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HUO02_RS03465 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUO02_RS03470 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUO02_RS03480 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUO02_RS03485 ENOG4108V3E phosphoribosylglycinamide formyltransferase HUO02_RS03490 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUO02_RS03495 ENOG4105C12 Phosphoribosylglycinamide synthetase HUO02_RS03510 ENOG4108R5T secreted protein HUO02_RS03515 ENOG4105KGF protein, YerC YecD HUO02_RS03520 ENOG4105CBC glutamate synthase HUO02_RS03530 ENOG4105C4R Atp-dependent dna helicase HUO02_RS03535 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUO02_RS03545 ENOG4105CRN Aminoglycoside phosphotransferase HUO02_RS03550 ENOG4105KT7 mgtC SapB transporter HUO02_RS03555 ENOG4105CK7 Sodium proline symporter HUO02_RS03560 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUO02_RS03565 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUO02_RS03570 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUO02_RS03575 ENOG4108IG5 Transcriptional regulator HUO02_RS03585 ENOG4105CBD Diacylglycerol kinase HUO02_RS03590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUO02_RS03595 ENOG4105CVR type I restriction-modification system HUO02_RS03605 ENOG4105DZR Type I site-specific deoxyribonuclease HUO02_RS03640 ENOG4105CDY transcriptional regulatory protein HUO02_RS03660 ENOG4105WEF catalase HUO02_RS03665 ENOG4105M18 -acetyltransferase HUO02_RS03675 ENOG4105H67 Protein of unknown function (DUF421) HUO02_RS03680 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HUO02_RS03685 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HUO02_RS03705 ENOG4106I4J membrane HUO02_RS03710 ENOG41082F9 transcriptional regulator HUO02_RS03715 ENOG41061H0 Monooxygenase HUO02_RS03720 ENOG4108R1P HUO02_RS03725 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUO02_RS03740 ENOG4105CJ1 ABC, transporter HUO02_RS03790 ENOG4105E0M Sulfatase HUO02_RS03795 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HUO02_RS03805 ENOG41090R9 glycosyltransferase HUO02_RS03810 ENOG4107R51 Glycosyl transferase, family 2 HUO02_RS03815 ENOG41090R9 glycosyltransferase HUO02_RS03820 ENOG4105EU0 Major facilitator Superfamily HUO02_RS03825 ENOG4105CUB amino acid HUO02_RS03830 ENOG4105C26 Dehydrogenase HUO02_RS03835 ENOG4105FKZ Methyl-accepting chemotaxis HUO02_RS03840 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUO02_RS03845 ENOG4107TVC Glycosyl transferase, family 2 HUO02_RS03850 ENOG4105C5H ABC transporter HUO02_RS03855 ENOG4107SWG transcriptional regulator MERR family HUO02_RS03860 ENOG4105DXB Major Facilitator superfamily HUO02_RS03865 ENOG4105C5H ABC transporter HUO02_RS03870 ENOG4105FDU atp-dependent rna helicase HUO02_RS03880 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUO02_RS03895 ENOG4108J20 pectate lyase HUO02_RS03900 ENOG4107QPK )-transporter HUO02_RS03930 ENOG4108MRH transcriptional regulatory protein HUO02_RS03955 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) HUO02_RS03960 ENOG4108RPX mosc domain containing protein HUO02_RS03980 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HUO02_RS04020 ENOG4105C5Y PTS System HUO02_RS04025 ENOG4105CG3 alpha amylase, catalytic region HUO02_RS04030 ENOG4107414 GntR family transcriptional regulator HUO02_RS04035 ENOG4108RCM Nitroreductase HUO02_RS04050 ENOG4105CGH 5'-nucleotidase HUO02_RS04055 ENOG4107RKG DJ-1/PfpI family HUO02_RS04060 ENOG4105ETE Transcriptional regulator (LacI family HUO02_RS04070 ENOG4105FF2 Type I DHQase HUO02_RS04085 ENOG4105KJF protein tyrosine phosphatase HUO02_RS04095 ENOG4107U9T Pfam:Ribonuclease_BN HUO02_RS04100 ENOG4108ISG Major Facilitator HUO02_RS04105 ENOG4105UPD Calcium Proton HUO02_RS04115 ENOG4105D8X mechanosensitive ion channel HUO02_RS04135 ENOG4106KE4 Dehydrogenase HUO02_RS04145 ENOG4105D7N magnesium and cobalt transport protein CorA HUO02_RS04155 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUO02_RS04175 ENOG4107RUY (E1 component), alpha subunit HUO02_RS04185 ENOG4107QKR Dehydrogenase HUO02_RS04195 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HUO02_RS04205 ENOG4105F8D glycoside hydrolase family 4 HUO02_RS04210 ENOG4108Q3X Transcriptional regulator HUO02_RS04215 ENOG4105CI1 PTS System HUO02_RS04225 ENOG4105BZ1 (ABC) transporter HUO02_RS04230 ENOG4105BZ1 (ABC) transporter HUO02_RS04240 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HUO02_RS04245 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUO02_RS04250 ENOG4105U3E Transcriptional regulator HUO02_RS04255 ENOG4105DYS nad(p)h dehydrogenase (quinone) HUO02_RS04260 ENOG4105H93 Acyltransferase family HUO02_RS04275 ENOG4108YYS metal-dependent hydrolase (By similarity) HUO02_RS04280 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUO02_RS04285 ENOG410834F Transcriptional regulator HUO02_RS04295 ENOG4105JAB phenazine biosynthesis protein, phzf family HUO02_RS04300 ENOG4107Y03 Nitroreductase HUO02_RS04315 ENOG4105ECP epimerase HUO02_RS04320 ENOG410902V Modulates RecA activity (By similarity) HUO02_RS04330 ENOG4105F27 Major Facilitator HUO02_RS04340 ENOG4108TCS Glutamyl endopeptidase HUO02_RS04360 ENOG4106AKJ HUO02_RS04365 ENOG4105D74 hydrolase HUO02_RS04370 ENOG4105CKK Glycosyl transferase, family 2 HUO02_RS04375 ENOG4105EJV Membrane HUO02_RS04380 ENOG41067AE Membrane-bound metal-dependent hydrolase HUO02_RS04385 ENOG4105CEN a g-specific adenine glycosylase HUO02_RS04390 ENOG4106BXE HUO02_RS04395 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HUO02_RS04415 ENOG4105BZ1 (ABC) transporter HUO02_RS04420 ENOG4107NBY Membrane HUO02_RS04425 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUO02_RS04430 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUO02_RS04435 ENOG4105G5W regulator Fur family HUO02_RS04440 ENOG4105TUA UPF0295 protein HUO02_RS04545 ENOG4107S6Z Na H antiporter HUO02_RS04550 ENOG4105EC3 peptidase S51, dipeptidase E HUO02_RS04555 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUO02_RS04560 ENOG4105DNP FAD linked oxidase domain protein HUO02_RS04585 ENOG4105E2Y ABC, transporter HUO02_RS04590 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HUO02_RS04595 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUO02_RS04605 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUO02_RS04610 ENOG4107D63 HUO02_RS04615 ENOG4105VZ8 Transcriptional regulator HUO02_RS04630 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HUO02_RS04640 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUO02_RS04660 ENOG4105CYN Serine protein kinase HUO02_RS04670 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUO02_RS04675 ENOG4105CW7 secretion protein, HlyD family HUO02_RS04680 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUO02_RS04685 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUO02_RS04700 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HUO02_RS04705 ENOG4105CZV ABC transporter HUO02_RS04710 ENOG4105CJ1 ABC, transporter HUO02_RS04715 ENOG4108TU7 Inherit from COG: (ABC) transporter HUO02_RS04720 ENOG4105VEQ Cold shock protein HUO02_RS04730 ENOG4105BZU Histidine kinase HUO02_RS04770 ENOG4108YBP pseudouridine synthase HUO02_RS04780 ENOG41080XP Cbs domain HUO02_RS04785 ENOG4107YBY Hydrolase HUO02_RS04790 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUO02_RS04795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUO02_RS04800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HUO02_RS04810 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUO02_RS04815 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUO02_RS04825 ENOG4105BZU Histidine kinase HUO02_RS04830 ENOG4105WH1 Two component transcriptional regulator luxr family HUO02_RS04865 ENOG4105ED1 spovr family HUO02_RS04870 ENOG4105G6Z alkaline phosphatase HUO02_RS04885 ENOG4105BZN citrate synthase HUO02_RS04890 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUO02_RS04895 ENOG4105CUB amino acid HUO02_RS04900 ENOG4105C8J )-transporter HUO02_RS04910 ENOG4105J37 HUO02_RS04915 ENOG4108AEY RNA polymerase sigma factor HUO02_RS04920 ENOG4105F6E Acyl-transferase HUO02_RS04925 ENOG4105C37 (CBS) domain HUO02_RS04935 ENOG4105CHM Aminotransferase HUO02_RS04940 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HUO02_RS04945 ENOG4105C37 (CBS) domain HUO02_RS04955 ENOG4105WMR Protein CrcB homolog HUO02_RS04960 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUO02_RS04970 ENOG4105D64 Mechanosensitive ion channel HUO02_RS04975 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUO02_RS04980 ENOG4107VMI polysaccharide deacetylase HUO02_RS04985 ENOG4105F0I Aminotransferase HUO02_RS04990 ENOG4105W1N transcriptional regulator HUO02_RS04995 ENOG4105IIP Membrane HUO02_RS05005 ENOG4105BZ1 (ABC) transporter HUO02_RS05010 ENOG4105BZ1 (ABC) transporter HUO02_RS05030 ENOG410839P HUO02_RS05040 ENOG4106MP8 UPF0754 membrane protein HUO02_RS05045 ENOG4105WZB UPF0342 protein HUO02_RS05050 ENOG4105F1N DNA alkylation repair HUO02_RS05060 ENOG4105D4P Coproporphyrinogen iii oxidase HUO02_RS05070 ENOG4107S91 Sodium hydrogen exchanger HUO02_RS05075 ENOG4105NCW Trka-c domain protein HUO02_RS05085 ENOG4105CGU Enoyl-CoA hydratase HUO02_RS05095 ENOG4108IUX (ABC) transporter HUO02_RS05100 ENOG4105RHA ABC transporter, permease HUO02_RS05105 ENOG4107VRP DNA repair exonuclease HUO02_RS05110 ENOG4106D4I domain protein HUO02_RS05115 ENOG4105EQI Metal Dependent Phosphohydrolase HUO02_RS05125 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HUO02_RS05170 ENOG4105NBU tryptophan transport protein HUO02_RS05175 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUO02_RS05180 ENOG4105K59 histidine triad (HIT) protein HUO02_RS05210 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HUO02_RS05215 ENOG4105BZ4 penicillin-binding protein HUO02_RS05220 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUO02_RS05225 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUO02_RS05230 ENOG4105C1Q protoporphyrinogen oxidase HUO02_RS05240 ENOG4105ECB domain protein HUO02_RS05255 ENOG4105DER m42 family HUO02_RS05265 ENOG4106AXD HUO02_RS05270 ENOG4108RQ5 Beta-lactamase domain-containing protein HUO02_RS05275 ENOG4105DF9 Lipoate-protein, ligase HUO02_RS05285 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS05295 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HUO02_RS05305 ENOG4106JUT Streptomycin 3''-adenylyltransferase HUO02_RS05330 ENOG4108HUF Transporter HUO02_RS05335 ENOG4107TB6 phosphoglycerate mutase HUO02_RS05345 ENOG4107F3J Amp-dependent synthetase and ligase HUO02_RS05350 ENOG4107ZYJ bioY protein HUO02_RS05355 ENOG4106YBV Methyl-accepting chemotaxis HUO02_RS05375 ENOG4105XVF Competence transcription factor HUO02_RS05385 ENOG4108ZMX Domain of unknown function (DU1801) HUO02_RS05400 ENOG4105X3H Excalibur domain protein HUO02_RS05405 ENOG4105K8R UPF0145 protein HUO02_RS05410 ENOG4105E1V na solute symporter HUO02_RS05415 ENOG4106CAD Protein of unknown function (DUF3311) HUO02_RS05420 ENOG41060YP HUO02_RS05435 ENOG4107SCK Monooxygenase HUO02_RS05440 ENOG4108INS Transcriptional regulator HUO02_RS05445 ENOG4108KK1 membrane protein AbrB duplication HUO02_RS05455 ENOG4108IG5 Transcriptional regulator HUO02_RS05465 ENOG4108QY0 Membrane HUO02_RS05470 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HUO02_RS05475 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HUO02_RS05485 ENOG4105EYH Exonuclease HUO02_RS05530 ENOG4105ERH Fumarylacetoacetate hydrolase HUO02_RS05550 ENOG4105CAQ asparagine synthetase HUO02_RS05560 ENOG4105UQX Mate efflux family protein HUO02_RS05565 ENOG4106HBX Transcriptional Regulator AraC Family HUO02_RS05570 ENOG4105SF0 DinB family HUO02_RS05575 ENOG4105MYW Pentapeptide repeat protein HUO02_RS05580 ENOG4105MA6 gCN5-related N-acetyltransferase HUO02_RS05590 ENOG4108VPT UPF0234 protein HUO02_RS05595 ENOG4105QNR S1 RNA binding domain protein HUO02_RS05600 ENOG4105DIH basic membrane HUO02_RS05605 ENOG4105C8Q Methyl-accepting chemotaxis HUO02_RS05610 ENOG4107E6A Cytochrome p-450 HUO02_RS05620 ENOG4105EPR degv family HUO02_RS05625 ENOG4107AYK membrAne HUO02_RS05635 ENOG41073B9 HUO02_RS05645 ENOG4108KP7 hydrolase HUO02_RS05650 ENOG4108MXZ Esterase HUO02_RS05655 ENOG4105VG1 fes assembly suf system protein HUO02_RS05660 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HUO02_RS05665 ENOG4105IQ5 FAD linked oxidase domain protein HUO02_RS05675 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUO02_RS05680 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUO02_RS05685 ENOG4105CAS nag kinase HUO02_RS05690 ENOG4105C8Y Acetylornithine aminotransferase HUO02_RS05695 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUO02_RS05705 ENOG4105DBV ornithine carbamoyltransferase HUO02_RS05730 ENOG4107RMD Basic membrane lipoprotein HUO02_RS05745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUO02_RS05750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUO02_RS05760 ENOG4105C3U ABC transporter HUO02_RS05765 ENOG4108JQ7 (ABC) transporter HUO02_RS05780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUO02_RS05790 ENOG4105C31 Tryptophanyl-tRNA synthetase HUO02_RS05795 ENOG4108J59 Extracellular solute-binding protein, family 5 HUO02_RS05800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUO02_RS05805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUO02_RS05815 ENOG4108JQ7 (ABC) transporter HUO02_RS05830 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HUO02_RS05835 ENOG4108ZCF integral membrane protein HUO02_RS05845 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HUO02_RS05855 ENOG4105DPN Oligoendopeptidase f HUO02_RS05865 ENOG4105T58 Dithiol-disulfide isomerase HUO02_RS05870 ENOG4108Z18 K06886 hemoglobin HUO02_RS05875 ENOG4105E4C Lytic transglycosylase catalytic HUO02_RS05880 ENOG4105MIX Adenylate cyclase HUO02_RS05895 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUO02_RS05900 ENOG4105EMS pseudouridine synthase HUO02_RS05905 ENOG4107S1Q Phosphatase HUO02_RS05915 ENOG4105ETU transcriptional activator (TenA HUO02_RS05920 ENOG4108VEU Thiamine monophosphate synthase HUO02_RS05940 ENOG4105D06 uba thif-type nad fad binding protein HUO02_RS05945 ENOG4105DWF phosphomethylpyrimidine kinase HUO02_RS05950 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUO02_RS05955 ENOG4107A88 HUO02_RS06005 ENOG4105ENA helicase HUO02_RS06025 ENOG4105CJ1 ABC, transporter HUO02_RS06040 ENOG4108ZMI UPF0477 protein HUO02_RS06050 ENOG4105C28 cystathionine HUO02_RS06055 ENOG4105C28 cystathionine HUO02_RS06070 ENOG4106BHF HUO02_RS06105 ENOG4106BHF HUO02_RS06145 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUO02_RS06160 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HUO02_RS06165 ENOG4105CMR udp-glucose 4-epimerase HUO02_RS06170 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUO02_RS06175 ENOG4105CK1 PTS System HUO02_RS06180 ENOG4105VCP PTS System HUO02_RS06210 ENOG4105KT7 mgtC SapB transporter HUO02_RS06235 ENOG4108IEG Formate dehydrogenase Alpha subunit HUO02_RS06245 ENOG4106A3M Cytochrome p-450 HUO02_RS06250 ENOG41087PP glycosyltransferase MGT family HUO02_RS06260 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HUO02_RS06265 ENOG4105C4B ABC transporter, permease HUO02_RS06270 ENOG4108IXI (ABC) transporter HUO02_RS06280 ENOG4105Q95 Cupin 2, conserved barrel domain protein HUO02_RS06295 ENOG4105D2H Uronic isomerase HUO02_RS06300 ENOG4105CT4 transporter HUO02_RS06305 ENOG4107KJX Transcriptional regulator HUO02_RS06310 ENOG4107QZW Altronate oxidoreductase HUO02_RS06315 ENOG4105CTX dehydratase HUO02_RS06320 ENOG4107TSN permease HUO02_RS06340 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HUO02_RS06345 ENOG4105KWG Pfam:DUF1696 HUO02_RS06350 ENOG4105K7W phage-related replication protein HUO02_RS06355 ENOG410635T phage-like element pbsx protein HUO02_RS06405 ENOG41068G1 HUO02_RS06435 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HUO02_RS06450 ENOG4105CJ3 phosphate transporter HUO02_RS06455 ENOG4107GRR phosphate transport regulator HUO02_RS06460 ENOG4107R7I amino acid HUO02_RS06470 ENOG4105EDW glycosyl transferase, family 39 HUO02_RS06475 ENOG4105CKK Glycosyl transferase, family 2 HUO02_RS06485 ENOG4105C0H protease HUO02_RS06495 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUO02_RS06500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUO02_RS06505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUO02_RS06510 ENOG4105C3U ABC transporter HUO02_RS06520 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUO02_RS06525 ENOG4105DTQ mandelate racemase muconate lactonizing HUO02_RS06530 ENOG4107SN7 NLP P60 protein HUO02_RS06535 ENOG4108JQ7 (ABC) transporter HUO02_RS06540 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUO02_RS06545 ENOG4107TUM Amidinotransferase HUO02_RS06550 ENOG4108S4H thioesterase Superfamily protein HUO02_RS06555 ENOG4108428 Inherit from COG: -acetyltransferase HUO02_RS06565 ENOG41080TC multidrug resistance protein HUO02_RS06570 ENOG4105CIY formyltetrahydrofolate deformylase HUO02_RS06575 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUO02_RS06590 ENOG4105K56 Transcriptional regulator HUO02_RS06595 ENOG4108ZHJ Organic hydroperoxide resistance protein HUO02_RS06610 ENOG4107TVC Glycosyl transferase, family 2 HUO02_RS06620 ENOG4105D8G Major Facilitator superfamily HUO02_RS06625 ENOG4108Y4K DNA-binding transcriptional activator HUO02_RS06630 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUO02_RS06635 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUO02_RS06645 ENOG4108W7F transporter, permease HUO02_RS06650 ENOG4108JJB ABC transporter HUO02_RS06655 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HUO02_RS06660 ENOG4105VRS hydrolase family 18 HUO02_RS06670 ENOG4105CJW magnesium transporter HUO02_RS06675 ENOG4105V75 Transcriptional regulator HUO02_RS06700 ENOG4105DQE DNA ligase HUO02_RS06705 ENOG4105FDF Could be involved in DNA repair (By similarity) HUO02_RS06710 ENOG4107T5V SNARE associated Golgi HUO02_RS06715 ENOG4107TS3 membrane protein, TerC HUO02_RS06720 ENOG4108WZW RNA polymerase sigma HUO02_RS06730 ENOG410681C small acid-soluble spore protein HUO02_RS06740 ENOG4105D0M Protease HtpX homolog HUO02_RS06750 ENOG410900G Protein of unknown function (DUF421) HUO02_RS06760 ENOG4108TGC Acyltransferase HUO02_RS06765 ENOG4105BZU Histidine kinase HUO02_RS06770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUO02_RS06775 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUO02_RS06785 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUO02_RS06795 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HUO02_RS06800 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HUO02_RS06805 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HUO02_RS06810 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HUO02_RS06820 ENOG4105BZU Histidine kinase HUO02_RS06825 ENOG41090MY MarR family Transcriptional regulator HUO02_RS06830 ENOG4105ER2 Ompa motb domain protein HUO02_RS06835 ENOG4105E14 MotA TolQ exbB proton channel HUO02_RS06845 ENOG4108K88 Membrane HUO02_RS06855 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HUO02_RS06860 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HUO02_RS06865 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HUO02_RS06870 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HUO02_RS06885 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUO02_RS06910 ENOG4105F0V Cell wall hydrolase HUO02_RS06925 ENOG4105C59 p-type ATPase HUO02_RS06930 ENOG4105DC7 peptidase M24 HUO02_RS06940 ENOG4105CID antiterminator HUO02_RS06950 ENOG4105KRI phosphocarrier protein (HPr HUO02_RS06955 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUO02_RS06965 ENOG4105F6S Spore photoproduct lyase HUO02_RS06970 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUO02_RS06975 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUO02_RS06985 ENOG4105K4I Scp-like extracellular HUO02_RS06995 ENOG4105BZU Histidine kinase HUO02_RS07000 ENOG4105CHM Aminotransferase HUO02_RS07010 ENOG4107R88 Chemotaxis protein (CheV) HUO02_RS07015 ENOG4105UIN HUO02_RS07025 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HUO02_RS07035 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HUO02_RS07045 ENOG4105EPM Diguanylate phosphodiesterase HUO02_RS07050 ENOG4107IN1 Protein of unknown function (DUF1797) HUO02_RS07055 ENOG4108XRC Protein of unknown function (DUF458) HUO02_RS07085 ENOG4105NQC Flavodoxin HUO02_RS07105 ENOG4105D8X mechanosensitive ion channel HUO02_RS07110 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUO02_RS07125 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUO02_RS07130 ENOG4105D06 uba thif-type nad fad binding protein HUO02_RS07135 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUO02_RS07140 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HUO02_RS07145 ENOG4108ZAF Molybdopterin HUO02_RS07150 ENOG41067WU Molybdopterin converting factor (Subunit 1) HUO02_RS07160 ENOG4107X8C Efflux transporter RND family MFP subunit HUO02_RS07165 ENOG4105C19 ABC transporter HUO02_RS07170 ENOG4107RBB ABC transporter, permease HUO02_RS07175 ENOG4105E98 transcriptional regulator DeoR family HUO02_RS07180 ENOG4105DE4 1-phosphofructokinase HUO02_RS07185 ENOG4105DM4 PTS System HUO02_RS07200 ENOG4105C5H ABC transporter HUO02_RS07205 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUO02_RS07230 ENOG4105BZU Histidine kinase HUO02_RS07240 ENOG4107ZYR domain protein HUO02_RS07245 ENOG4105CPN adenine deaminase HUO02_RS07250 ENOG4105CN5 Metallo-Beta-Lactamase HUO02_RS07255 ENOG4106148 UPF0356 protein HUO02_RS07260 ENOG4108X4Q Hydrolase HUO02_RS07265 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUO02_RS07280 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUO02_RS07285 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS07290 ENOG4107SQU synthase HUO02_RS07295 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS07300 ENOG4107SQU synthase HUO02_RS07305 ENOG4107SQU synthase HUO02_RS07310 ENOG4107SQU synthase HUO02_RS07315 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS07320 ENOG4105FQP Beta-lactamase HUO02_RS07330 ENOG4105CPP Dehydrogenase, E1 component HUO02_RS07335 ENOG4105C7S Dehydrogenase HUO02_RS07340 ENOG4107QN2 dihydrolipoyl dehydrogenase HUO02_RS07360 ENOG4105CXN decarboxylase HUO02_RS07365 ENOG4105WBI UPF0223 protein HUO02_RS07380 ENOG4105ECY inositol monophosphatase HUO02_RS07445 ENOG4105CI3 gtp-binding protein typa HUO02_RS07450 ENOG4105QA2 HUO02_RS07465 ENOG4108IAB Phoh family HUO02_RS07475 ENOG4105CSV Glutaminase HUO02_RS07485 ENOG4105CNI cell division protein FtsW HUO02_RS07490 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HUO02_RS07500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUO02_RS07510 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUO02_RS07515 ENOG4105CCU oxidase (Subunit III) HUO02_RS07520 ENOG41064X9 cytochrome C oxidase subunit IV HUO02_RS07535 ENOG41080XQ Signal transduction protein with cbs domains HUO02_RS07540 ENOG4106UY4 Inherit from COG: Scp-like extracellular HUO02_RS07565 ENOG4106H78 methyltransferase HUO02_RS07570 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUO02_RS07575 ENOG4105H20 Sporulation integral membrane protein YlbJ HUO02_RS07580 ENOG4105D78 K07001 NTE family protein HUO02_RS07585 ENOG41063PX domain protein HUO02_RS07590 ENOG4105CDE UPF0348 protein HUO02_RS07595 ENOG4105KNH Nucleic acid-binding protein HUO02_RS07625 ENOG4108V6E Cell division protein mraZ HUO02_RS07630 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUO02_RS07640 ENOG4105CJN penicillin-binding protein HUO02_RS07645 ENOG4105CJN penicillin-binding protein HUO02_RS07650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUO02_RS07655 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUO02_RS07660 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUO02_RS07665 ENOG4105CNI cell division protein FtsW HUO02_RS07670 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUO02_RS07675 ENOG4105D4A Cell wall formation (By similarity) HUO02_RS07680 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HUO02_RS07685 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HUO02_RS07690 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUO02_RS07700 ENOG4105FFI sigma-e processing peptidase spoiiga HUO02_RS07705 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS07715 ENOG4105DKW ABC transporter HUO02_RS07725 ENOG4105WR5 sporulation protein, YlmC YmxH family HUO02_RS07730 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUO02_RS07735 ENOG4105DFA alanine racemase domain protein HUO02_RS07740 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUO02_RS07745 ENOG41067XK integral membrane protein HUO02_RS07750 ENOG4105DBK s4 domain protein HUO02_RS07760 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUO02_RS07770 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUO02_RS07775 ENOG4105C34 Pseudouridine synthase HUO02_RS07780 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUO02_RS07790 ENOG4105CXT aspartate transcarbamylase HUO02_RS07800 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUO02_RS07805 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUO02_RS07810 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HUO02_RS07815 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HUO02_RS07820 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HUO02_RS07825 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUO02_RS07840 ENOG4107RIQ Sulfate adenylate transferase HUO02_RS07850 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUO02_RS07855 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HUO02_RS07860 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HUO02_RS07875 ENOG4105DSJ YicC domain protein HUO02_RS07880 ENOG4105KC4 UPF0296 protein HUO02_RS07885 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUO02_RS07895 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HUO02_RS07900 ENOG4105C25 Primosomal protein n' HUO02_RS07905 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUO02_RS07910 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUO02_RS07915 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HUO02_RS07920 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUO02_RS07925 ENOG4108ZF3 Phosphatase HUO02_RS07930 ENOG4105D9P serine threonine protein kinase HUO02_RS07935 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUO02_RS07940 ENOG4105DJV ribulose-phosphate 3-epimerase HUO02_RS07945 ENOG4105FJ0 thiamine HUO02_RS07955 ENOG4105VB9 50S ribosomal protein l28 HUO02_RS07960 ENOG4108ZAA Alkaline-shock protein HUO02_RS07965 ENOG4105DP4 dak2 domain fusion protein ylov HUO02_RS07975 ENOG4105EJQ L-serine dehydratase HUO02_RS07980 ENOG4105CB5 ATP-dependent DNA helicase recG HUO02_RS07985 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HUO02_RS07990 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUO02_RS07995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUO02_RS08000 ENOG4105CHR reductase HUO02_RS08010 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUO02_RS08015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUO02_RS08020 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HUO02_RS08030 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HUO02_RS08040 ENOG4105K5M 30s ribosomal protein S16 HUO02_RS08045 ENOG4108BW8 UPF0109 protein HUO02_RS08060 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUO02_RS08065 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUO02_RS08070 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HUO02_RS08075 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUO02_RS08085 ENOG4105VM1 flagellar HUO02_RS08090 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUO02_RS08095 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HUO02_RS08100 ENOG4105C79 DNA protecting protein DprA HUO02_RS08105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUO02_RS08110 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HUO02_RS08115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUO02_RS08120 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HUO02_RS08125 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HUO02_RS08135 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HUO02_RS08140 ENOG4108ZC9 flagellar basal-body rod protein flgc HUO02_RS08145 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HUO02_RS08150 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HUO02_RS08155 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HUO02_RS08170 ENOG4106YF4 Flagellar biosynthesis chaperone HUO02_RS08180 ENOG410696Y Flagellar hook-length control protein HUO02_RS08185 ENOG410822I Flagellar hook capping protein HUO02_RS08190 ENOG4108JQA flagellar HUO02_RS08195 ENOG41068WV flagellar FlbD family protein HUO02_RS08205 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HUO02_RS08210 ENOG4105DD5 Flagellar motor switch protein HUO02_RS08215 ENOG4107YTP response regulator receiver protein HUO02_RS08225 ENOG4105CN7 Flagellar biosynthetic protein FliP HUO02_RS08230 ENOG4105VS8 Flagellar biosynthetic protein fliq HUO02_RS08235 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HUO02_RS08240 ENOG4105D00 flagellar biosynthetic protein flhB HUO02_RS08245 ENOG4105D7B Flagellar biosynthesis protein flha HUO02_RS08250 ENOG4105FZW flagellar biosynthesis regulator FlhF HUO02_RS08260 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUO02_RS08265 ENOG4105CBS Chea signal transduction histidine kinase HUO02_RS08270 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HUO02_RS08280 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HUO02_RS08285 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS08295 ENOG4105CE9 30S ribosomal protein S2 HUO02_RS08305 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUO02_RS08310 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUO02_RS08315 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUO02_RS08320 ENOG4105KNE Phosphatidate cytidylyltransferase HUO02_RS08330 ENOG4105DZP Membrane-associated zinc metalloprotease HUO02_RS08335 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUO02_RS08340 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HUO02_RS08345 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HUO02_RS08350 ENOG4105CHV Transcription elongation factor NusA HUO02_RS08355 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HUO02_RS08360 ENOG4105VHM ribosomal protein HUO02_RS08365 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUO02_RS08370 ENOG4105W7A Protein of unknown function (DUF503) HUO02_RS08375 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUO02_RS08380 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUO02_RS08385 ENOG4105DTN riboflavin biosynthesis protein ribF HUO02_RS08390 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUO02_RS08395 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUO02_RS08405 ENOG4105C1V Peptidase, M16 HUO02_RS08415 ENOG4105E35 Dipicolinate synthase subunit A HUO02_RS08420 ENOG4108S0H Dipicolinic acid synthetase, b subunit HUO02_RS08425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HUO02_RS08435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUO02_RS08445 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HUO02_RS08455 ENOG4105CNU cell division protein FtsK HUO02_RS08460 ENOG4105FDP GntR family transcriptional regulator HUO02_RS08475 ENOG4105EYF MMPL domain protein HUO02_RS08490 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HUO02_RS08495 ENOG4105XZV Protein of unknown function (DUF3243) HUO02_RS08510 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HUO02_RS08515 ENOG4105CEV competence damage-inducible protein HUO02_RS08520 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUO02_RS08525 ENOG4108A04 Beta-lactamase HUO02_RS08535 ENOG4105D48 metallophosphoesterase HUO02_RS08540 ENOG4105MCT stage V sporulation protein S HUO02_RS08545 ENOG4105CPQ Dehydrogenase HUO02_RS08550 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUO02_RS08555 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUO02_RS08575 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUO02_RS08585 ENOG4108151 Beta-lactamase domain protein HUO02_RS08590 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUO02_RS08595 ENOG4108JA1 polyketide synthase HUO02_RS08600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUO02_RS08605 ENOG41062T2 Acyl carrier protein HUO02_RS08610 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HUO02_RS08615 ENOG4108MGH Enoyl-CoA hydratase HUO02_RS08620 ENOG4108KQ6 Enoyl-CoA hydratase HUO02_RS08625 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS08630 ENOG4107SQU synthase HUO02_RS08640 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS08650 ENOG4106A3M Cytochrome p-450 HUO02_RS08655 ENOG4105WFK nuclease HUO02_RS08660 ENOG4105XPP Protein of unknown function (DUF1275) HUO02_RS08670 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUO02_RS08680 ENOG4105K7W phage-related replication protein HUO02_RS08685 ENOG4108X3M OsmC Ohr family protein HUO02_RS08710 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUO02_RS08735 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUO02_RS08740 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUO02_RS08745 ENOG4105U6W MutT NUDIX family protein HUO02_RS08750 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUO02_RS08755 ENOG4106F1P AAA ATPase, central domain protein HUO02_RS08760 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUO02_RS08765 ENOG4105CXI aluminum resistance protein HUO02_RS08770 ENOG4105KV4 Transcriptional regulator HUO02_RS08775 ENOG4105C5F glutamine synthetase HUO02_RS08800 ENOG4105CT4 transporter HUO02_RS08805 ENOG4105DSG hydrolase family 43 HUO02_RS08815 ENOG4105C93 Xylose Isomerase HUO02_RS08820 ENOG4105CMG Carbohydrate kinase HUO02_RS08825 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUO02_RS08855 ENOG4105DQ4 alcohol dehydrogenase HUO02_RS08870 ENOG4105EPI acetyltransferase, (GNAT) family HUO02_RS08905 ENOG4108M1A Chitin-binding protein HUO02_RS08930 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUO02_RS08940 ENOG4105K7W phage-related replication protein HUO02_RS08965 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUO02_RS08975 ENOG4108SVB resolvase HUO02_RS08980 ENOG4105VPS UPF0291 protein HUO02_RS08985 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUO02_RS08995 ENOG4105VXM UPF0154 protein HUO02_RS09005 ENOG4107QIV Cytochrome c biogenesis protein HUO02_RS09040 ENOG4108I0Z Aconitate hydratase HUO02_RS09045 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUO02_RS09060 ENOG41067CD Small, acid-soluble spore protein Tlp HUO02_RS09070 ENOG4105MI2 HUO02_RS09075 ENOG4105W8X HesB YadR YfhF-family protein HUO02_RS09080 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HUO02_RS09085 ENOG4105K4P CoA-binding domain protein HUO02_RS09090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUO02_RS09115 ENOG4105CPQ Dehydrogenase HUO02_RS09120 ENOG4108UHU Aldolase HUO02_RS09125 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HUO02_RS09130 ENOG4105DMW Dehydrogenase reductase HUO02_RS09140 ENOG4108I5G Major Facilitator superfamily HUO02_RS09155 ENOG4105FVX HUO02_RS09190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS09200 ENOG4107SYN Glycosyl hydrolases family 43 HUO02_RS09225 ENOG4105DTD Dehydrogenase HUO02_RS09230 ENOG4108IIH CoA-transferase subunit B HUO02_RS09235 ENOG4105D6N CoA-transferase, subunit a HUO02_RS09240 ENOG4105CY2 Citrate transporter HUO02_RS09245 ENOG4106A3M Cytochrome p-450 HUO02_RS09250 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUO02_RS09255 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUO02_RS09260 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUO02_RS09265 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUO02_RS09270 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HUO02_RS09280 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUO02_RS09285 ENOG4107T5V SNARE associated Golgi HUO02_RS09290 ENOG4107QX3 carboxylase HUO02_RS09295 ENOG4105E39 Enoyl-CoA hydratase HUO02_RS09300 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUO02_RS09305 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HUO02_RS09310 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUO02_RS09315 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS09320 ENOG4105C1G acyl-Coa dehydrogenase HUO02_RS09325 ENOG4105F32 YngK protein HUO02_RS09330 ENOG4106U2H Protein of unknown function (DUF1360) HUO02_RS09340 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS09345 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS09355 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS09360 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HUO02_RS09365 ENOG4108N2V aldose 1-epimerase HUO02_RS09370 ENOG4107QJQ Mate efflux family protein HUO02_RS09395 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUO02_RS09400 ENOG4108RWP Major Facilitator Superfamily protein HUO02_RS09405 ENOG4105WAB arsR family transcriptional regulator HUO02_RS09410 ENOG4105C22 threonyL-tRNA synthetase HUO02_RS09415 ENOG4108KSA LysR family transcriptional regulator HUO02_RS09420 ENOG4105CB2 alcohol dehydrogenase HUO02_RS09430 ENOG4105BZ8 glutamate synthase HUO02_RS09435 ENOG4105CBC glutamate synthase HUO02_RS09440 ENOG4105C5Q Transcriptional regulator HUO02_RS09445 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUO02_RS09470 ENOG4105CHR reductase HUO02_RS09490 ENOG4108UB7 HUO02_RS09495 ENOG4105IE8 Alpha-ketoglutarate permease HUO02_RS09500 ENOG4107U6E carbohydrate kinase FGGY HUO02_RS09505 ENOG4108M3J Dehydrogenase HUO02_RS09510 ENOG4108J2R molybdopterin oxidoreductase HUO02_RS09535 ENOG4106ANW SMI1_KNR4 HUO02_RS09540 ENOG4106BHF HUO02_RS09545 ENOG4108Z7R Chaperone CsaA HUO02_RS09550 ENOG4105FTV AraC Family Transcriptional Regulator HUO02_RS09560 ENOG4108W8B Beta-lactamase domain protein HUO02_RS09570 ENOG4105KTU Transcriptional regulator, arsr family HUO02_RS09580 ENOG4108SJC Membrane HUO02_RS09605 ENOG41069ER domain protein HUO02_RS09610 ENOG4105C9U ATP-dependent DNA helicase RecQ HUO02_RS09620 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUO02_RS09625 ENOG4105SCY DNAK suppressor HUO02_RS09670 ENOG4105C26 Dehydrogenase HUO02_RS09675 ENOG4105EWU Squalene--hopene cyclase HUO02_RS09680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUO02_RS09685 ENOG4105C8J )-transporter HUO02_RS09690 ENOG4105C09 Bile acid HUO02_RS09700 ENOG4105C7S Dehydrogenase HUO02_RS09705 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUO02_RS09710 ENOG4107T89 von Willebrand factor, type A HUO02_RS09715 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUO02_RS09725 ENOG4105K4H Nlp p60 protein HUO02_RS09730 ENOG41087PP glycosyltransferase MGT family HUO02_RS09740 ENOG4107QMU Mate efflux family protein HUO02_RS09745 ENOG4106SCS STAS domain HUO02_RS09765 ENOG4105FR1 rard protein HUO02_RS09780 ENOG41090U3 tautomerase HUO02_RS09800 ENOG4105FBA Phospholipase Carboxylesterase HUO02_RS09815 ENOG4105E1V na solute symporter HUO02_RS09825 ENOG4105CS2 ec 3.2.1.21 HUO02_RS09830 ENOG4108S3Y transcriptional regulator HUO02_RS09850 ENOG4108VXD carboxy-peptidase HUO02_RS09855 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HUO02_RS09865 ENOG4106Z5R HUO02_RS09870 ENOG410841Q phosphoesterase PA-phosphatase related protein HUO02_RS09905 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUO02_RS09910 ENOG4108TSC N-acetyltransferase HUO02_RS09915 ENOG4107S4Y M20 DapE family protein YgeY HUO02_RS09930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUO02_RS10015 ENOG4107TPS domain protein HUO02_RS10030 ENOG4105BZU Histidine kinase HUO02_RS10035 ENOG41087NI Sulfite exporter TauE/SafE HUO02_RS10070 ENOG4105E0X reductase HUO02_RS10075 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUO02_RS10085 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HUO02_RS10090 ENOG41090WU lipolytic protein G-D-S-L family HUO02_RS10095 ENOG4108KF3 Electron transport protein SCO1 SenC HUO02_RS10105 ENOG4105C7B Threonine dehydratase HUO02_RS10115 ENOG4108UT2 hemolysin iii HUO02_RS10125 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUO02_RS10130 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUO02_RS10140 ENOG4107YX5 Pfam:DUF548 HUO02_RS10145 ENOG4108Y6J UPF0403 protein HUO02_RS10150 ENOG4105C01 Dihydroxy-acid dehydratase HUO02_RS10165 ENOG4108V06 Glutathione peroxidase HUO02_RS10170 ENOG4105CVG Homoserine O-transsuccinylase HUO02_RS10215 ENOG41081VK Ribonuclease HUO02_RS10240 ENOG410890F Dynamin family HUO02_RS10255 ENOG41065KQ synthase HUO02_RS10275 ENOG410900G Protein of unknown function (DUF421) HUO02_RS10290 ENOG4105C2W permease HUO02_RS10295 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HUO02_RS10300 ENOG4105CTD carboxy-peptidase HUO02_RS10305 ENOG4105DVT helicase HUO02_RS10325 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HUO02_RS10335 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HUO02_RS10340 ENOG4108UKS UPF0398 protein HUO02_RS10355 ENOG4107X2U Inherit from COG: Exonuclease-like protein HUO02_RS10360 ENOG4108I5C dEAD DEAH box helicase HUO02_RS10405 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HUO02_RS10410 ENOG4105BZ4 penicillin-binding protein HUO02_RS10420 ENOG4105CSM endonuclease III HUO02_RS10430 ENOG4105C5S asparaginyl-tRNA synthetase HUO02_RS10435 ENOG4105CHM Aminotransferase HUO02_RS10445 ENOG4105YAC HUO02_RS10450 ENOG4105DVT helicase HUO02_RS10455 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUO02_RS10465 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUO02_RS10475 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUO02_RS10480 ENOG4105CPK Glycosyl transferase (Group 1 HUO02_RS10485 ENOG4105FJR Lmbe family HUO02_RS10490 ENOG4108Z5K methylglyoxal synthase HUO02_RS10495 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUO02_RS10500 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HUO02_RS10505 ENOG4108JYZ YitT family HUO02_RS10510 ENOG4105F0F Oxalate decarboxylase HUO02_RS10530 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUO02_RS10550 ENOG41068YB TPR repeat-containing protein HUO02_RS10555 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUO02_RS10565 ENOG4105CIH Imidazole acetol-phosphate transaminase HUO02_RS10575 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUO02_RS10580 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HUO02_RS10585 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUO02_RS10595 ENOG4105CRQ synthase (Component I) HUO02_RS10600 ENOG4105KHN chorismate mutase HUO02_RS10610 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUO02_RS10615 ENOG4105BZU Histidine kinase HUO02_RS10620 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUO02_RS10625 ENOG4105EAH synthase HUO02_RS10630 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUO02_RS10635 ENOG4105XXQ heptaprenyl diphosphate synthase component I HUO02_RS10640 ENOG4105WP2 Tryptophan RNA-binding attenuator protein HUO02_RS10645 ENOG4105EUJ GTP cyclohydrolase i HUO02_RS10650 ENOG4105K70 DNA-binding protein HUO02_RS10655 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HUO02_RS10670 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUO02_RS10675 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUO02_RS10695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUO02_RS10700 ENOG4105CAT Cytidine monophosphate kinase HUO02_RS10715 ENOG4105MSI germination protein ypeb HUO02_RS10725 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HUO02_RS10730 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HUO02_RS10745 ENOG4107RGJ metallophosphoesterase HUO02_RS10760 ENOG4105I7S Abortive infection protein HUO02_RS10765 ENOG4105C9U ATP-dependent DNA helicase RecQ HUO02_RS10770 ENOG4105T7X HUO02_RS10780 ENOG4108SAX Membrane HUO02_RS10785 ENOG4108JQ1 Dehydrogenase HUO02_RS10800 ENOG4105BZU Histidine kinase HUO02_RS10805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUO02_RS10810 ENOG4105CRE cytochrome C HUO02_RS10815 ENOG4107TWT Cytochrome c biogenesis protein HUO02_RS10825 ENOG4105FE9 pseudouridine synthase HUO02_RS10835 ENOG4108JIC nucleoside recognition domain protein HUO02_RS10840 ENOG4105DZ1 carboxypeptidase HUO02_RS10850 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUO02_RS10855 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUO02_RS10875 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUO02_RS10880 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUO02_RS10885 ENOG4108R6K riboflavin synthase, subunit alpha HUO02_RS10910 ENOG4107ZE5 PPIases accelerate the folding of proteins HUO02_RS10915 ENOG4105PTM secreted protein HUO02_RS10920 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUO02_RS10930 ENOG4105G6R Stage v sporulation protein ae HUO02_RS10940 ENOG4105CZ3 stage V sporulation protein ad HUO02_RS10945 ENOG41090VF Stage v sporulation protein ac HUO02_RS10960 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS10965 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUO02_RS10970 ENOG41082AN stage II sporulation protein HUO02_RS10975 ENOG4105DZ1 carboxypeptidase HUO02_RS10980 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HUO02_RS10985 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HUO02_RS10990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUO02_RS11000 ENOG4105I3K Ferric uptake regulator, Fur family HUO02_RS11005 ENOG4105MZ9 stage II sporulation protein m HUO02_RS11025 ENOG4105DFD Na H antiporter HUO02_RS11030 ENOG4108IJ0 Aspartate ammonia-lyase HUO02_RS11035 ENOG4105HDK L-asparaginase HUO02_RS11040 ENOG4108IMY Transcriptional regulator HUO02_RS11050 ENOG4108YZ4 nudix hydrolase HUO02_RS11060 ENOG4105CPC Aldo Keto reductase HUO02_RS11080 ENOG4106HZJ HUO02_RS11085 ENOG4105RHY Pfam:UPF0157 HUO02_RS11090 ENOG4105KAC Antibiotic biosynthesis monooxygenase HUO02_RS11095 ENOG4108XET gCN5-related N-acetyltransferase HUO02_RS11100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUO02_RS11115 ENOG4105C02 permease HUO02_RS11125 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HUO02_RS11130 ENOG4105CS9 pantothenic acid kinase HUO02_RS11140 ENOG4108IXY short-chain dehydrogenase reductase HUO02_RS11145 ENOG41069FQ Metallo-beta-lactamase superfamily HUO02_RS11150 ENOG4105II7 pyrroline-5-carboxylate reductase HUO02_RS11155 ENOG4108KQ6 Enoyl-CoA hydratase HUO02_RS11160 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HUO02_RS11165 ENOG4106A3M Cytochrome p-450 HUO02_RS11180 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS11185 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS11195 ENOG4105C0W non-ribosomal peptide synthetase HUO02_RS11205 ENOG4105CHR reductase HUO02_RS11210 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS11225 ENOG4107QKG PfaD family HUO02_RS11230 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUO02_RS11235 ENOG4108K70 Transcriptional regulator HUO02_RS11245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUO02_RS11255 ENOG410861F 50S ribosomal protein L33 HUO02_RS11260 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUO02_RS11265 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUO02_RS11270 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUO02_RS11275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUO02_RS11285 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HUO02_RS11290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HUO02_RS11295 ENOG4108HNZ carboxyl transferase HUO02_RS11300 ENOG4108ZVT methylmalonyl-coA epimerase HUO02_RS11310 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HUO02_RS11315 ENOG4108QEG Membrane HUO02_RS11320 ENOG4105CDA abc transporter atp-binding protein HUO02_RS11325 ENOG4105E5Q amino acid AbC transporter HUO02_RS11330 ENOG4108HW3 (ABC) transporter HUO02_RS11335 ENOG4108Y6J UPF0403 protein HUO02_RS11340 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HUO02_RS11345 ENOG4105C7S Dehydrogenase HUO02_RS11350 ENOG4105CPP Dehydrogenase, E1 component HUO02_RS11365 ENOG4105CKM Branched-chain carboxylic acid kinase HUO02_RS11370 ENOG4107RDP Dehydrogenase HUO02_RS11380 ENOG4108JUB Transcriptional regulator HUO02_RS11385 ENOG4106CCJ Protein of unknown function (DUF2627) HUO02_RS11390 ENOG4105CR4 methylisocitrate lyase HUO02_RS11395 ENOG4105DXD 2-methylcitrate dehydratase HUO02_RS11405 ENOG4105C1G acyl-Coa dehydrogenase HUO02_RS11410 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUO02_RS11420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUO02_RS11425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUO02_RS11450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUO02_RS11465 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUO02_RS11470 ENOG4107QQR Sporulation HUO02_RS11475 ENOG4105S1Z Stage IV sporulation protein B HUO02_RS11480 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUO02_RS11485 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUO02_RS11490 ENOG4105DX0 Hemolysin A HUO02_RS11495 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUO02_RS11500 ENOG4105CTB Polyprenyl synthetase HUO02_RS11505 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUO02_RS11510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUO02_RS11515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUO02_RS11520 ENOG4105M7K Involved in the transcription termination process (By similarity) HUO02_RS11525 ENOG4108ZSR alkaline shock protein HUO02_RS11530 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUO02_RS11550 ENOG410644B Stage III sporulation protein af HUO02_RS11560 ENOG4105KQ4 Stage iii sporulation protein ad HUO02_RS11565 ENOG4108CQH stage III sporulation protein AC HUO02_RS11570 ENOG4105KR5 Stage iii sporulation protein HUO02_RS11575 ENOG4105CD2 stage iii sporulation protein aa HUO02_RS11585 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUO02_RS11590 ENOG4105DC7 peptidase M24 HUO02_RS11600 ENOG4105CBJ Metal-dependent enzyme HUO02_RS11620 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HUO02_RS11625 ENOG4105WZW rhodanese family HUO02_RS11630 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUO02_RS11640 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUO02_RS11645 ENOG4105C0D helicase HUO02_RS11660 ENOG4108IMY Transcriptional regulator HUO02_RS11670 ENOG4105VFR signal peptidase HUO02_RS11730 ENOG4105C37 (CBS) domain HUO02_RS11755 ENOG4105C5X domain protein HUO02_RS11800 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HUO02_RS11815 ENOG41068DG YceG-like family HUO02_RS11820 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUO02_RS11825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUO02_RS11830 ENOG4105E2Z phosphate ABC transporter (Permease HUO02_RS11835 ENOG4105C8U phosphate abc transporter HUO02_RS11840 ENOG4105CVA phosphate HUO02_RS11850 ENOG4107RF6 penicillin-binding protein HUO02_RS11860 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUO02_RS11865 ENOG4105SXS Protein of unknown function (DUF456) HUO02_RS11880 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUO02_RS11885 ENOG41063Y9 HUO02_RS11890 ENOG4108U5J '-nucleotidase HUO02_RS11895 ENOG4105N80 Ferric uptake regulator, Fur family HUO02_RS11900 ENOG4108JYZ YitT family HUO02_RS11905 ENOG41069ZM Protein of unknown function (DUF2624) HUO02_RS11910 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUO02_RS11925 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUO02_RS11930 ENOG4105EGD dinuclear metal center protein, YbgI family HUO02_RS11945 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS11950 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUO02_RS11955 ENOG4108UPT UPF0178 protein HUO02_RS11960 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HUO02_RS11970 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HUO02_RS11975 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HUO02_RS11980 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUO02_RS11990 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUO02_RS11995 ENOG4105KG3 cytidine deaminase HUO02_RS12000 ENOG4107YR5 Diacylglycerol kinase HUO02_RS12005 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUO02_RS12010 ENOG4105CTJ Metal Dependent Phosphohydrolase HUO02_RS12015 ENOG4105C9A Phoh family HUO02_RS12020 ENOG4105EI1 sporulation protein yqfd HUO02_RS12025 ENOG41068P3 sporulation protein YqfC HUO02_RS12035 ENOG4105DI5 UPF0365 protein HUO02_RS12040 ENOG4105F7J membrane-bound serine protease HUO02_RS12045 ENOG4105KTH gatB Yqey HUO02_RS12060 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUO02_RS12065 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HUO02_RS12070 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUO02_RS12075 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUO02_RS12080 ENOG4105CFG Acts as a chaperone (By similarity) HUO02_RS12085 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUO02_RS12090 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUO02_RS12095 ENOG4105CSA Coproporphyrinogen iii oxidase HUO02_RS12100 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUO02_RS12110 ENOG4108ZRV stage ii sporulation protein p HUO02_RS12115 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HUO02_RS12120 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUO02_RS12125 ENOG4105TQK DNA polymerase iii, delta' subunit HUO02_RS12140 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HUO02_RS12145 ENOG4108UK2 deaminase HUO02_RS12150 ENOG4105KQC Competence protein HUO02_RS12160 ENOG4108D32 Methyltransferase HUO02_RS12170 ENOG4108WF2 Metal Dependent Phosphohydrolase HUO02_RS12175 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUO02_RS12180 ENOG410812S Rna-binding protein HUO02_RS12185 ENOG4105E2X shikimate dehydrogenase HUO02_RS12190 ENOG4105CQW ribosome biogenesis GTPase YqeH HUO02_RS12195 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HUO02_RS12215 ENOG41080BT SNARE associated Golgi HUO02_RS12230 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS12250 ENOG4108SWU Histidine kinase HUO02_RS12255 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS12260 ENOG4105DHF Membrane HUO02_RS12265 ENOG4108UYN gCN5-related N-acetyltransferase HUO02_RS12270 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUO02_RS12295 ENOG4108HCJ Hydrolase HUO02_RS12300 ENOG4108HCJ Hydrolase HUO02_RS12310 ENOG4105DG6 mannose-6-phosphate isomerase HUO02_RS12315 ENOG4105DM4 PTS System HUO02_RS12330 ENOG4108Z66 YbaK ebsC protein HUO02_RS12335 ENOG4107RSM transcriptional regulator HUO02_RS12340 ENOG4105D94 Major Facilitator Superfamily HUO02_RS12345 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUO02_RS12350 ENOG41082JN Transcriptional regulator HUO02_RS12370 ENOG4105TMB Formate nitrite transporter HUO02_RS12375 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HUO02_RS12380 ENOG4108JB9 formate dehydrogenase HUO02_RS12395 ENOG4105C28 cystathionine HUO02_RS12425 ENOG4107XRG penicillin-binding protein HUO02_RS12430 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUO02_RS12440 ENOG4105CFP Peptidase U32 HUO02_RS12445 ENOG4105XYU peptidase (U32 family) HUO02_RS12455 ENOG4105HHA aminodeoxychorismate lyase HUO02_RS12465 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUO02_RS12470 ENOG4105VBH UPF0297 protein HUO02_RS12475 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUO02_RS12480 ENOG4105C02 permease HUO02_RS12485 ENOG4105CDA abc transporter atp-binding protein HUO02_RS12490 ENOG4105CT1 (ABC) transporter HUO02_RS12495 ENOG4105EAD ABC transporter HUO02_RS12500 ENOG4105DRP amino acid AbC transporter HUO02_RS12510 ENOG41060CR HUO02_RS12520 ENOG4105C7H Helicase, RecD TraA family HUO02_RS12530 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUO02_RS12535 ENOG4105C3J Cysteine desulfurase HUO02_RS12545 ENOG4105D1H recombination factor protein RarA HUO02_RS12550 ENOG4105CUZ uba thif-type nad fad binding protein HUO02_RS12560 ENOG4105C9M aspartyl-trna synthetase HUO02_RS12565 ENOG4105CUT histidyl-tRNA synthetase HUO02_RS12575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUO02_RS12580 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUO02_RS12585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUO02_RS12595 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HUO02_RS12600 ENOG41067VP Protein of unknown function (DUF1049) HUO02_RS12605 ENOG4105NCW Trka-c domain protein HUO02_RS12610 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUO02_RS12620 ENOG4105CKP Polysaccharide Biosynthesis Protein HUO02_RS12625 ENOG4108QG2 Membrane HUO02_RS12630 ENOG4105NAP HUO02_RS12635 ENOG4105VIE preprotein translocase, subunit YajC HUO02_RS12640 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HUO02_RS12645 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUO02_RS12650 ENOG41061AI Protein of unknown function (DUF2905) HUO02_RS12655 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUO02_RS12660 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUO02_RS12680 ENOG4106678 morphogenetic protein associated with SpoVID HUO02_RS12685 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUO02_RS12690 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HUO02_RS12695 ENOG4108IYU L-aspartate oxidase HUO02_RS12710 ENOG4105CQC Prephenate dehydratase HUO02_RS12720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUO02_RS12730 ENOG4105K46 50S ribosomal protein l27 HUO02_RS12735 ENOG4105X36 (ribosomal) protein HUO02_RS12740 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUO02_RS12755 ENOG4107QMS site-determining protein HUO02_RS12760 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HUO02_RS12765 ENOG4105YHC Rod shape-determining protein MreD HUO02_RS12775 ENOG4105DFF Rod shape-determining protein mreb HUO02_RS12780 ENOG4105W5Q DNA repair protein (RadC HUO02_RS12785 ENOG4108Z03 MAF-like protein HUO02_RS12795 ENOG4106A3R peptidase HUO02_RS12800 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUO02_RS12805 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUO02_RS12815 ENOG4106AR7 Spore coat protein HUO02_RS12820 ENOG41068KH stage VI sporulation protein D HUO02_RS12825 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUO02_RS12830 ENOG4105D52 delta-aminolevulinic acid dehydratase HUO02_RS12840 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUO02_RS12850 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUO02_RS12860 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HUO02_RS12865 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUO02_RS12870 ENOG4108IUQ atp-dependent protease HUO02_RS12875 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUO02_RS12880 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUO02_RS12890 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUO02_RS12895 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUO02_RS12900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUO02_RS12910 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUO02_RS12915 ENOG4108ZP8 Acetolactate synthase small subunit HUO02_RS12920 ENOG4105C7K acetolactate synthase HUO02_RS12945 ENOG4105M59 Phosphodiesterase, mj0936 family HUO02_RS12950 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUO02_RS12955 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUO02_RS12960 ENOG4108XJQ germination protein HUO02_RS12965 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUO02_RS12970 ENOG41067TZ transcriptional regulator, MarR family HUO02_RS12975 ENOG4105PFC Transcriptional regulator HUO02_RS12985 ENOG4105E33 succinate dehydrogenase HUO02_RS12995 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HUO02_RS13005 ENOG4105CFH Aspartokinase HUO02_RS13010 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUO02_RS13015 ENOG4105K63 Thioredoxin HUO02_RS13020 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUO02_RS13025 ENOG4105C10 Electron transfer flavoprotein HUO02_RS13030 ENOG4105BZJ Electron transfer flavoprotein HUO02_RS13035 ENOG41060WC Enoyl-CoA hydratase HUO02_RS13040 ENOG4107Z3H Transcriptional regulator, TetR family HUO02_RS13045 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS13050 ENOG4108YV3 Protein of unknown function (DUF2711) HUO02_RS13060 ENOG4105C98 muts2 protein HUO02_RS13065 ENOG4105DCG PHP domain protein HUO02_RS13080 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUO02_RS13085 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUO02_RS13090 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUO02_RS13095 ENOG4108RWN rrna methyltransferase HUO02_RS13100 ENOG41067MF small acid-soluble spore protein HUO02_RS13110 ENOG4105CQB FAD linked oxidase domain protein HUO02_RS13115 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUO02_RS13125 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUO02_RS13130 ENOG4105DRS transport system, permease HUO02_RS13145 ENOG4108MDK Dehydrogenase HUO02_RS13155 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HUO02_RS13160 ENOG4105EF1 ribulokinase HUO02_RS13170 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HUO02_RS13175 ENOG4105CN9 Peptidase m42 family protein HUO02_RS13185 ENOG410696E Membrane HUO02_RS13190 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUO02_RS13195 ENOG4105VJV 50s ribosomal protein L35 HUO02_RS13200 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUO02_RS13205 ENOG41067MG lrgb family HUO02_RS13215 ENOG4105DY9 regulatoR HUO02_RS13220 ENOG4108HRK Histidine kinase HUO02_RS13230 ENOG4105C22 threonyL-tRNA synthetase HUO02_RS13235 ENOG4108TDW sporulation protein YtxC HUO02_RS13260 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HUO02_RS13265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUO02_RS13270 ENOG4105KVH Transcriptional regulator HUO02_RS13275 ENOG4105F27 Major Facilitator HUO02_RS13280 ENOG4105CV8 reductase HUO02_RS13285 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUO02_RS13295 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUO02_RS13300 ENOG4105C2M dna polymerase I HUO02_RS13305 ENOG4105BZU Histidine kinase HUO02_RS13310 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS13320 ENOG4108HMX isocitrate dehydrogenase (NADP) HUO02_RS13325 ENOG4105BZN citrate synthase HUO02_RS13330 ENOG4105G7B Protein of unknown function (DUF2992) HUO02_RS13340 ENOG4108REF Sporulation integral membrane protein ytvi HUO02_RS13345 ENOG4105FS0 cytoplasmic membrane protein HUO02_RS13350 ENOG4105CA9 Pyruvate kinase HUO02_RS13355 ENOG4105CTQ phosphohexokinase HUO02_RS13360 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HUO02_RS13365 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HUO02_RS13370 ENOG4105C6K Malic enzyme HUO02_RS13375 ENOG4105C0B DNA polymerase III (alpha subunit) HUO02_RS13380 ENOG4105VV2 HUO02_RS13390 ENOG4106EVM HUO02_RS13395 ENOG4105SFS phosphoesterase RecJ domain protein HUO02_RS13410 ENOG4105E8R UPF0173 metal-dependent hydrolase HUO02_RS13420 ENOG4105CH7 arginosuccinase HUO02_RS13425 ENOG4105CDH Citrulline--aspartate ligase HUO02_RS13430 ENOG4105EPU Molybdenum cofactor synthesis domain protein HUO02_RS13435 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUO02_RS13445 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HUO02_RS13450 ENOG4105KBJ sporulation protein ytfj HUO02_RS13460 ENOG4105VK3 rdd domain containing protein HUO02_RS13465 ENOG4105D07 Signal peptide peptidase, SppA HUO02_RS13470 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUO02_RS13475 ENOG4105EFZ amidohydrolase HUO02_RS13480 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUO02_RS13490 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HUO02_RS13515 ENOG4105U5Y Transcriptional regulator HUO02_RS13525 ENOG4105BZU Histidine kinase HUO02_RS13530 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUO02_RS13535 ENOG4105C26 Dehydrogenase HUO02_RS13580 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUO02_RS13595 ENOG4108Z0Z intracellular protease Pfpi family HUO02_RS13615 ENOG4108NGU Transcriptional regulator HUO02_RS13630 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUO02_RS13640 ENOG4105F1V Acetoin utilization protein HUO02_RS13645 ENOG4105W87 Cbs domain HUO02_RS13650 ENOG4105DGU Histone deacetylase HUO02_RS13655 ENOG4105ER2 Ompa motb domain protein HUO02_RS13660 ENOG4107R0U MotA TolQ exbB proton channel HUO02_RS13665 ENOG4105ETE Transcriptional regulator (LacI family HUO02_RS13670 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HUO02_RS13690 ENOG4105DFU Cell wall formation (By similarity) HUO02_RS13700 ENOG4108VDD TRNA binding domain protein HUO02_RS13715 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HUO02_RS13730 ENOG4105C6K Malic enzyme HUO02_RS13735 ENOG4105C8F Beta-lactamase domain protein HUO02_RS13740 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUO02_RS13750 ENOG4108V15 phosphotransferase enzyme family HUO02_RS13765 ENOG4107F58 2'-5' rna ligase HUO02_RS13770 ENOG4105C6T cysteine synthase HUO02_RS13775 ENOG4107QSE Dipeptidase HUO02_RS13780 ENOG4105C7N Xanthine uracil vitamin C permease HUO02_RS13795 ENOG4105YW5 deoR family transcriptional regulator HUO02_RS13810 ENOG4105CBX hi0933 family HUO02_RS13815 ENOG4105C94 Transporter HUO02_RS13855 ENOG41085GJ domain protein HUO02_RS13860 ENOG4105C8T Leucyl-tRNA synthetase HUO02_RS13870 ENOG4105BZU Histidine kinase HUO02_RS13875 ENOG410605W Major Facilitator HUO02_RS13890 ENOG4105C19 ABC transporter HUO02_RS13895 ENOG4105EWM Histidine kinase HUO02_RS13905 ENOG4107R34 abc transporter permease protein HUO02_RS13910 ENOG4105C19 ABC transporter HUO02_RS13930 ENOG4105DVE abc transporter atp-binding protein HUO02_RS13935 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUO02_RS13980 ENOG4105N5T Radical SAM Protein HUO02_RS13995 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HUO02_RS14005 ENOG4105E8V Alpha Beta Hydrolase Fold protein HUO02_RS14010 ENOG4108Z0R Transferase HUO02_RS14015 ENOG4105C85 amino acid HUO02_RS14020 ENOG4105CAQ asparagine synthetase HUO02_RS14025 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUO02_RS14030 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HUO02_RS14045 ENOG4105D2X ABC transporter substrate-binding protein HUO02_RS14055 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HUO02_RS14070 ENOG4108RMU ferritin dps family protein HUO02_RS14085 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HUO02_RS14090 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUO02_RS14095 ENOG4108V2W Carbonate dehydratase HUO02_RS14100 ENOG4105NRA 50s ribosomal protein l31 type b HUO02_RS14120 ENOG4105DTQ mandelate racemase muconate lactonizing HUO02_RS14125 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS14130 ENOG4108IPT Naphthoate synthase HUO02_RS14135 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HUO02_RS14140 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HUO02_RS14145 ENOG4105E4F Isochorismate synthase HUO02_RS14280 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HUO02_RS14285 ENOG4105DZ6 Band 7 protein HUO02_RS14295 ENOG4106DF1 HUO02_RS14300 ENOG4108VNY MOSC domain protein HUO02_RS14305 ENOG4108JB8 alcohol dehydrogenase HUO02_RS14315 ENOG4105TRT Transcriptional regulator HUO02_RS14330 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HUO02_RS14335 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUO02_RS14355 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUO02_RS14365 ENOG4105EE0 oxidoreductase HUO02_RS14370 ENOG4108Z0Z intracellular protease Pfpi family HUO02_RS14375 ENOG4105C8Q Methyl-accepting chemotaxis HUO02_RS14380 ENOG4105C8Q Methyl-accepting chemotaxis HUO02_RS14385 ENOG4105C8Q Methyl-accepting chemotaxis HUO02_RS14390 ENOG4105C8Q Methyl-accepting chemotaxis HUO02_RS14405 ENOG4105EA8 2-Nitropropane dioxygenase HUO02_RS14410 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HUO02_RS14420 ENOG4105C37 (CBS) domain HUO02_RS14435 ENOG4107PBV potassium channel HUO02_RS14440 ENOG4107PBV potassium channel HUO02_RS14455 ENOG4107QYV phosphohexose isomerase HUO02_RS14465 ENOG4105CHJ isochorismatase hydrolase HUO02_RS14475 ENOG4107QW4 alcohol dehydrogenase HUO02_RS14480 ENOG4105WG9 Conserved Protein HUO02_RS14490 ENOG4105CHM Aminotransferase HUO02_RS14495 ENOG4108ZB6 transcriptional regulator AsnC family HUO02_RS14500 ENOG4108MUZ hydrolase HUO02_RS14510 ENOG4105C87 Aminotransferase class I and II HUO02_RS14515 ENOG4108HGU Histidine kinase HUO02_RS14520 ENOG4105Y38 Kinase-associated protein B HUO02_RS14535 ENOG4105BZ4 penicillin-binding protein HUO02_RS14540 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HUO02_RS14555 ENOG4108MRH transcriptional regulatory protein HUO02_RS14560 ENOG4105DIH basic membrane HUO02_RS14565 ENOG4108JQ9 ABC transporter HUO02_RS14570 ENOG4105UIB (ABC) transporter HUO02_RS14585 ENOG4105D65 subunit l HUO02_RS14590 ENOG4105HC0 Na H antiporter HUO02_RS14595 ENOG4108ZE9 Monovalent cation H antiporter subunit C HUO02_RS14600 ENOG4108JPZ Monovalent cation H antiporter subunit D HUO02_RS14605 ENOG4105SC1 monovalent cation H antiporter subunit E HUO02_RS14615 ENOG4105KJM monovalent cation h antiporter subunit g HUO02_RS14620 ENOG4105KA0 thioesterase Superfamily protein HUO02_RS14630 ENOG4105BZU Histidine kinase HUO02_RS14655 ENOG4105D58 Diguanylate phosphodiesterase HUO02_RS14660 ENOG4105DAP Nicotinate phosphoribosyltransferase HUO02_RS14685 ENOG4105C02 permease HUO02_RS14700 ENOG410904N short-chain dehydrogenase reductase HUO02_RS14735 ENOG4108K8K Transcriptional regulator HUO02_RS14740 ENOG4105DCF alanine dehydrogenase HUO02_RS14750 ENOG4105WQT MbtH domain protein HUO02_RS14755 ENOG4105CEY Amp-dependent synthetase and ligase HUO02_RS14760 ENOG4105WQI isochorismatase HUO02_RS14765 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUO02_RS14770 ENOG4105E4F Isochorismate synthase HUO02_RS14775 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUO02_RS14780 ENOG4105NIV Esterase HUO02_RS14800 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUO02_RS14810 ENOG41069ER domain protein HUO02_RS14825 ENOG4105CEP NADH dehydrogenase HUO02_RS14840 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HUO02_RS14855 ENOG4105CJ1 ABC, transporter HUO02_RS14875 ENOG4105D9U N-acetyltransferase HUO02_RS14880 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HUO02_RS14885 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HUO02_RS14890 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUO02_RS14900 ENOG4105ZKE UPF0349 protein HUO02_RS14915 ENOG41083MR nifu domain-containing protein HUO02_RS14920 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUO02_RS14925 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUO02_RS14930 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUO02_RS14935 ENOG4105D6E homoserine dehydrogenase HUO02_RS14945 ENOG4108W5N phosphatidylglycerophosphatase a HUO02_RS14950 ENOG4105D4U had-superfamily hydrolase, subfamily iia HUO02_RS14960 ENOG4105MMD transcriptional regulator HUO02_RS14965 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUO02_RS14970 ENOG4105FAA peptidase M23 HUO02_RS14975 ENOG4108YTE sporulation protein YunB HUO02_RS14980 ENOG4107R8B 5'-nucleotidase HUO02_RS14990 ENOG4105I3N Conserved Protein HUO02_RS15000 ENOG4105CD3 dihydroorotase HUO02_RS15005 ENOG4105G9B Transcriptional regulator HUO02_RS15020 ENOG4105C5R Aminotransferase HUO02_RS15030 ENOG4108K8S endonuclease I HUO02_RS15035 ENOG4108IJ9 (ABC) transporter HUO02_RS15040 ENOG4105FDP GntR family transcriptional regulator HUO02_RS15045 ENOG4108KPW sugar kinase HUO02_RS15050 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUO02_RS15055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUO02_RS15060 ENOG4105XN3 extracellular solute-binding protein family 1 HUO02_RS15065 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HUO02_RS15070 ENOG4108Z6Z Transcriptional regulator HUO02_RS15085 ENOG4105PKS Excinuclease abc c subunit domain protein HUO02_RS15090 ENOG4107VFR oxidoreductase HUO02_RS15095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUO02_RS15105 ENOG41083Q9 chitosanase HUO02_RS15110 ENOG4105DIW FeS assembly protein SUFB HUO02_RS15115 ENOG4108UNV SUF system FeS assembly protein, NifU family HUO02_RS15120 ENOG4105C9B Cysteine desulfurase HUO02_RS15125 ENOG4105JRK feS assembly protein SufD HUO02_RS15130 ENOG4105C3K feS assembly ATPase SufC HUO02_RS15145 ENOG4105D01 (LipO)protein HUO02_RS15150 ENOG4108UMI ABC transporter, permease HUO02_RS15155 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUO02_RS15180 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUO02_RS15185 ENOG41080E8 Transcriptional regulator, Spx MgsR family HUO02_RS15190 ENOG4105C1G acyl-Coa dehydrogenase HUO02_RS15195 ENOG4105CHU acetyl-coa acetyltransferase HUO02_RS15225 ENOG41067TZ transcriptional regulator, MarR family HUO02_RS15230 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUO02_RS15235 ENOG4105MDS 4-oxalocrotonate tautomerase HUO02_RS15245 ENOG4105EGI Transcriptional regulator HUO02_RS15255 ENOG4105C5Q Transcriptional regulator HUO02_RS15275 ENOG4105E0A ABC, transporter HUO02_RS15290 ENOG4105E1F short-chain dehydrogenase reductase HUO02_RS15295 ENOG4105HUF DNA protection during starvation protein HUO02_RS15300 ENOG4105C0H protease HUO02_RS15310 ENOG4105F3H Histidine kinase HUO02_RS15320 ENOG41067SE Tetr family transcriptional regulator HUO02_RS15325 ENOG4105C9Q fumarate hydratase class II HUO02_RS15350 ENOG4105WH1 Two component transcriptional regulator luxr family HUO02_RS15355 ENOG4105ENE Histidine kinase HUO02_RS15370 ENOG41087YS Phage shock protein A HUO02_RS15385 ENOG4108WBT adenosyltransferase HUO02_RS15390 ENOG4105E0A ABC, transporter HUO02_RS15395 ENOG4105EHG Permease protein HUO02_RS15400 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUO02_RS15405 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUO02_RS15410 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HUO02_RS15420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS15430 ENOG4106DF4 Sigma-70, region 4 HUO02_RS15440 ENOG4105F0F Oxalate decarboxylase HUO02_RS15450 ENOG4105E0A ABC, transporter HUO02_RS15455 ENOG4105EHG Permease protein HUO02_RS15460 ENOG4105DQ5 transport system permease protein HUO02_RS15470 ENOG4105D5Q Arginine ornithine antiporter HUO02_RS15480 ENOG4107K5X Membrane-bound metal-dependent hydrolase HUO02_RS15485 ENOG4107QZ2 Sulfatase HUO02_RS15490 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HUO02_RS15495 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HUO02_RS15500 ENOG4105E0C molybdate abc transporter HUO02_RS15505 ENOG4105WH1 Two component transcriptional regulator luxr family HUO02_RS15510 ENOG4105BZU Histidine kinase HUO02_RS15515 ENOG4105CJ1 ABC, transporter HUO02_RS15525 ENOG4108KYE ABC-2 type transporter HUO02_RS15540 ENOG4105EEQ Na H antiporter HUO02_RS15545 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUO02_RS15550 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUO02_RS15555 ENOG4105EEM helicase HUO02_RS15560 ENOG4105EN6 Membrane HUO02_RS15575 ENOG4107ZQN disulfide bond HUO02_RS15580 ENOG4105C59 p-type ATPase HUO02_RS15585 ENOG4105C59 p-type ATPase HUO02_RS15590 ENOG410681U heavy metal transport detoxification protein HUO02_RS15595 ENOG4105VPX protein, conserved in bacteria HUO02_RS15600 ENOG4105D9R oxidoreductase HUO02_RS15605 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUO02_RS15640 ENOG4105DEN Luciferase family HUO02_RS15645 ENOG4105CDA abc transporter atp-binding protein HUO02_RS15670 ENOG4108XSB acetyltransferase, (GNAT) family HUO02_RS15675 ENOG4108KSA LysR family transcriptional regulator HUO02_RS15680 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUO02_RS15685 ENOG41067XF inhibitor HUO02_RS15695 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUO02_RS15700 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUO02_RS15710 ENOG4105XZU Preprotein translocase, subunit SecG HUO02_RS15730 ENOG4105KVH Transcriptional regulator HUO02_RS15755 ENOG4105DA5 (ABC) transporter HUO02_RS15760 ENOG4105R40 Glycine betaine carnitine choline HUO02_RS15765 ENOG4108HQR Glycine betaine HUO02_RS15770 ENOG4105E90 ABC transporter HUO02_RS15775 ENOG4108IJ8 ABC transporter HUO02_RS15780 ENOG4107HG4 Transcriptional regulator HUO02_RS15785 ENOG4105R40 Glycine betaine carnitine choline HUO02_RS15790 ENOG4108HQR Glycine betaine HUO02_RS15795 ENOG4105E90 ABC transporter HUO02_RS15800 ENOG4108IJ8 ABC transporter HUO02_RS15805 ENOG4107HG4 Transcriptional regulator HUO02_RS15810 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HUO02_RS15820 ENOG4105T65 Membrane-associated protein HUO02_RS15825 ENOG4108W0I acetyltransferase HUO02_RS15840 ENOG4105FJR Lmbe family HUO02_RS15855 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUO02_RS15860 ENOG4108IAJ Nad-dependent epimerase dehydratase HUO02_RS15865 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUO02_RS15870 ENOG4107QQG Dehydrogenase HUO02_RS15875 ENOG4105IIU Aminopeptidase HUO02_RS15880 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUO02_RS15885 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUO02_RS15890 ENOG4105CP7 Triose-phosphate isomerase HUO02_RS15895 ENOG4105BZA Phosphoglycerate kinase HUO02_RS15900 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUO02_RS15915 ENOG4105CMD Transcriptional regulator, GntR family HUO02_RS15920 ENOG4105DEN Luciferase family HUO02_RS15930 ENOG4105GZI Transcriptional regulator HUO02_RS15935 ENOG4107RT3 EamA-like transporter family HUO02_RS15960 ENOG410667J hydrolase HUO02_RS15965 ENOG4106KNT transcriptional regulator HUO02_RS15970 ENOG4105CMG Carbohydrate kinase HUO02_RS15975 ENOG4105C6Z Gluconate HUO02_RS15985 ENOG4107QR9 Iron-sulfur cluster binding protein HUO02_RS15990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUO02_RS15995 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUO02_RS16000 ENOG4105JXH GntR family transcriptional regulator HUO02_RS16005 ENOG4105DAA L-lactate HUO02_RS16010 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUO02_RS16020 ENOG4108ZPC Polysaccharide pyruvyl transferase HUO02_RS16025 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUO02_RS16030 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HUO02_RS16035 ENOG4105D3Q Sugar transferase HUO02_RS16045 ENOG4105K64 Glycosyl transferase, family 2 HUO02_RS16055 ENOG4107QRS glycosyltransferase group 2 family protein HUO02_RS16060 ENOG41068W6 Capsular polysaccharide biosynthesis protein HUO02_RS16065 ENOG4108KMV Glycosyl transferase (Group 1 HUO02_RS16070 ENOG4105K64 Glycosyl transferase, family 2 HUO02_RS16075 ENOG4108PQP glycosyl transferase group 1 HUO02_RS16085 ENOG4108QV3 biosynthesis protein HUO02_RS16090 ENOG4105HTX biosynthesis protein HUO02_RS16100 ENOG4105EBR Carboxylesterase HUO02_RS16105 ENOG4105NAE bifunctional deaminase-reductase domain protein HUO02_RS16115 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HUO02_RS16120 ENOG4105PY6 Phenolic acid decarboxylase HUO02_RS16125 ENOG4105NI3 Protein of unknown function (DUF3237) HUO02_RS16165 ENOG4108HKT sucrose-6-phosphate hydrolase HUO02_RS16170 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HUO02_RS16175 ENOG4105ETE Transcriptional regulator (LacI family HUO02_RS16180 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUO02_RS16185 ENOG4108KAM Transcriptional regulator HUO02_RS16190 ENOG4105C7F AcnD-accessory protein PrpF HUO02_RS16200 ENOG4108URH decarboxylase HUO02_RS16205 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HUO02_RS16210 ENOG4105CHH sulfate transporter HUO02_RS16215 ENOG4108V2W Carbonate dehydratase HUO02_RS16220 ENOG4105C5I Dehydrogenase HUO02_RS16225 ENOG4105GGE ribonuclease HUO02_RS16230 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUO02_RS16235 ENOG4105KRI phosphocarrier protein (HPr HUO02_RS16240 ENOG4105CIE May be required for sporulation (By similarity) HUO02_RS16245 ENOG4105CHW UPF0052 protein HUO02_RS16250 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUO02_RS16255 ENOG4108Z4K mutator MutT protein HUO02_RS16260 ENOG4105C3M thioredoxin reductase HUO02_RS16275 ENOG4105BZU Histidine kinase HUO02_RS16280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUO02_RS16285 ENOG4105BZ1 (ABC) transporter HUO02_RS16290 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUO02_RS16295 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUO02_RS16300 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUO02_RS16305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUO02_RS16310 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUO02_RS16315 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUO02_RS16320 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUO02_RS16325 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HUO02_RS16335 ENOG4108S4C acetyltransferase HUO02_RS16340 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUO02_RS16350 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HUO02_RS16355 ENOG4105CE4 GlcNAc 6-P deacetylase HUO02_RS16360 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HUO02_RS16370 ENOG4105J7D transcriptional regulator HUO02_RS16375 ENOG41088CQ domain protein HUO02_RS16380 ENOG41086DT Membrane protein of unknown function HUO02_RS16385 ENOG41067S9 phage shock protein C, PspC HUO02_RS16390 ENOG4108PY7 HUO02_RS16405 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUO02_RS16410 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUO02_RS16425 ENOG4105MKU Transcriptional regulator HUO02_RS16445 ENOG4105CN1 protease HUO02_RS16450 ENOG4108M26 parallel beta-helix repeat protein HUO02_RS16455 ENOG4105CRP Part of the ABC transporter FtsEX involved in HUO02_RS16460 ENOG4105CAK Cell division ATP-binding protein ftsE HUO02_RS16480 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUO02_RS16485 ENOG4105MS2 ribosomal subunit Interface protein HUO02_RS16500 ENOG4105MQ3 flagellar protein FliS HUO02_RS16505 ENOG4107RT6 flagellar hook-associated HUO02_RS16510 ENOG4105I03 Flagellin HUO02_RS16515 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HUO02_RS16520 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HUO02_RS16530 ENOG4105DTJ flagellar hook-associated protein HUO02_RS16535 ENOG4105E1Q flagellar hook-associated protein HUO02_RS16550 ENOG4105RU3 HUO02_RS16555 ENOG41081UC Inherit from COG: Competence protein HUO02_RS16575 ENOG4105WH1 Two component transcriptional regulator luxr family HUO02_RS16580 ENOG4105BZU Histidine kinase HUO02_RS16585 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUO02_RS16590 ENOG4108KGH TRANSCRIPTIONal HUO02_RS16595 ENOG4105ESV Glycosyl transferase, family 4 HUO02_RS16600 ENOG4107EF8 Glycosyl transferase (Group 1 HUO02_RS16615 ENOG4105QZI O-Antigen Polymerase HUO02_RS16620 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUO02_RS16625 ENOG4107RA4 Glycosyl transferase (Group 1 HUO02_RS16630 ENOG4105PSV Polysaccharide Biosynthesis Protein HUO02_RS16635 ENOG4105D3Q Sugar transferase HUO02_RS16640 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUO02_RS16645 ENOG4105JFG SpoIID LytB domain protein HUO02_RS16660 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUO02_RS16665 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUO02_RS16670 ENOG4105EY8 ABC transporter HUO02_RS16680 ENOG4107SJB teichoic acid biosynthesis HUO02_RS16690 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HUO02_RS16700 ENOG4107RZX Teichoic acid biosynthesis protein HUO02_RS16710 ENOG4105DG6 mannose-6-phosphate isomerase HUO02_RS16725 ENOG4108NHD germination protein HUO02_RS16730 ENOG4107R8N Glycosyl transferase, family 2 HUO02_RS16735 ENOG4105C54 Major Facilitator superfamily HUO02_RS16740 ENOG4108KGH TRANSCRIPTIONal HUO02_RS16745 ENOG4105J7I hydrolase HUO02_RS16750 ENOG4106UBQ HUO02_RS16755 ENOG4105K4H Nlp p60 protein HUO02_RS16765 ENOG4105PNM synthesis protein HUO02_RS16775 ENOG4105N98 Capsule biosynthesis protein capB HUO02_RS16795 ENOG4105ETE Transcriptional regulator (LacI family HUO02_RS16800 ENOG4108RVA ribokinase HUO02_RS16805 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUO02_RS16810 ENOG4105C2J ABC transporter HUO02_RS16815 ENOG4105CNN ABC, transporter HUO02_RS16820 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUO02_RS16830 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HUO02_RS16835 ENOG4107FQX Alpha-acetolactate decarboxylase HUO02_RS16845 ENOG4107RSM transcriptional regulator HUO02_RS16860 ENOG4106UIA HUO02_RS16875 ENOG4107XC4 flavin reductase domain protein, FMN-binding HUO02_RS16885 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUO02_RS16895 ENOG4105CAH Chromate HUO02_RS16900 ENOG4105FGV Chromate HUO02_RS16905 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUO02_RS17005 ENOG4108XI2 Domain of unknown function (DUF1963) HUO02_RS17010 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUO02_RS17015 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HUO02_RS17020 ENOG4107YJ4 chain length determinant protein HUO02_RS17025 ENOG4105HTX biosynthesis protein HUO02_RS17035 ENOG4105KBK Zinc finger, swim domain protein HUO02_RS17040 ENOG4105C0D helicase HUO02_RS17045 ENOG410667J hydrolase HUO02_RS17050 ENOG4105E98 transcriptional regulator DeoR family HUO02_RS17055 ENOG4105Z8H single-stranded DNA-binding protein HUO02_RS17070 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUO02_RS17075 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUO02_RS17085 ENOG4105CGA flagellar basal-body rod protein FlgG HUO02_RS17095 ENOG4105DFF Rod shape-determining protein mreb HUO02_RS17100 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HUO02_RS17105 ENOG4107MII Sugar-specific transcriptional regulator TrmB HUO02_RS17110 ENOG4105CZM Major Facilitator HUO02_RS17115 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUO02_RS17120 ENOG41080V3 Major Facilitator superfamily HUO02_RS17125 ENOG4105D3W isochorismatase HUO02_RS17130 ENOG4105BZU Histidine kinase HUO02_RS17140 ENOG4105CNI cell division protein FtsW HUO02_RS17145 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUO02_RS17155 ENOG4105FRN stage II sporulation protein HUO02_RS17160 ENOG4107TCE N-acetyltransferase HUO02_RS17175 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUO02_RS17180 ENOG4106BRK HUO02_RS17185 ENOG4107T94 Endo-14-beta-xylanase HUO02_RS17190 ENOG4108Z40 Transcriptional regulator HUO02_RS17195 ENOG4105CQM Urea amidohydrolase subunit alpha HUO02_RS17200 ENOG4105KI2 Urea amidohydrolase subunit beta HUO02_RS17205 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUO02_RS17225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUO02_RS17230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUO02_RS17240 ENOG4108TF4 von Willebrand factor, type A HUO02_RS17255 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUO02_RS17265 ENOG4106778 Protein of unknown function (DUF1146) HUO02_RS17275 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUO02_RS17280 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUO02_RS17285 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUO02_RS17290 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUO02_RS17295 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUO02_RS17310 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HUO02_RS17320 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUO02_RS17325 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUO02_RS17330 ENOG4108UIC UPF0340 protein HUO02_RS17335 ENOG4108YZG isomerase HUO02_RS17340 ENOG4107WAU Protein tyrosine phosphatase HUO02_RS17345 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HUO02_RS17350 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUO02_RS17360 ENOG4108ZXQ stage ii sporulation protein r HUO02_RS17375 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUO02_RS17380 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUO02_RS17385 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HUO02_RS17395 ENOG4107TT2 Auxin Efflux Carrier HUO02_RS17400 ENOG4105C6K Malic enzyme HUO02_RS17405 ENOG4107104 thymidine kinase HUO02_RS17415 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HUO02_RS17420 ENOG4105CBT Fructose-1,6-bisphosphatase HUO02_RS17425 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUO02_RS17435 ENOG4105D2N Aldolase HUO02_RS17440 ENOG410812K response regulator receiver protein HUO02_RS17450 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUO02_RS17460 ENOG4105DF6 Fe-S oxidoreductase HUO02_RS17470 ENOG4105E5J UV damage endonuclease HUO02_RS17480 ENOG4105BZ1 (ABC) transporter HUO02_RS17485 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUO02_RS17500 ENOG4105R3A Nitrate reductase HUO02_RS17505 ENOG4108IUE nitrate reductase beta subunit HUO02_RS17525 ENOG4107V6Q Cyclic nucleotide-binding domain HUO02_RS17535 ENOG4105C75 arginyL-tRNA synthetase HUO02_RS17540 ENOG410684U Domain of unknown function (DUF1934) HUO02_RS17560 ENOG4107JM4 Tetratricopeptide repeat HUO02_RS17600 ENOG4105CYW agmatinase HUO02_RS17605 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUO02_RS17610 ENOG4105BZ4 penicillin-binding protein HUO02_RS17620 ENOG4108XFG YwhD family HUO02_RS17625 ENOG4108Z4T Peptidase M50 HUO02_RS17630 ENOG41069HH 4-oxalocrotonate tautomerase HUO02_RS17635 ENOG41067TZ transcriptional regulator, MarR family HUO02_RS17640 ENOG4105CUB amino acid HUO02_RS17650 ENOG4105DCI Phosphohydrolase HUO02_RS17660 ENOG4108VCI transcription factor, rsfa family HUO02_RS17665 ENOG4105K7K Transcriptional regulator HUO02_RS17675 ENOG4105CJ1 ABC, transporter HUO02_RS17680 ENOG4108TU7 Inherit from COG: (ABC) transporter HUO02_RS17705 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HUO02_RS17710 ENOG4105DUM transcriptional regulator, lysR family HUO02_RS17715 ENOG4105HMI Membrane HUO02_RS17720 ENOG4108IJ2 phosphate acetyltransferase HUO02_RS17725 ENOG4107JTW chlorite dismutase HUO02_RS17735 ENOG4105CHM Aminotransferase HUO02_RS17765 ENOG4105FCW Major Facilitator superfamily HUO02_RS17770 ENOG4105C2C drug resistance transporter, Bcr CflA HUO02_RS17785 ENOG4105C26 Dehydrogenase HUO02_RS17790 ENOG4105D82 Glutamate dehydrogenase HUO02_RS17800 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS17820 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HUO02_RS17825 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUO02_RS17830 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUO02_RS17835 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HUO02_RS17840 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HUO02_RS17845 ENOG4107TY6 Acylneuraminate cytidylyltransferase HUO02_RS17855 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HUO02_RS17860 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUO02_RS17895 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUO02_RS17900 ENOG4108RJ9 Glycosyl transferase, family 2 HUO02_RS17920 ENOG4105DWF phosphomethylpyrimidine kinase HUO02_RS17935 ENOG4105C5Y PTS System HUO02_RS17950 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HUO02_RS17955 ENOG4105DEN Luciferase family HUO02_RS17965 ENOG4108DBC nitroreductase HUO02_RS17975 ENOG4105I4A GCN5-related N-acetyltransferase HUO02_RS17995 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUO02_RS18000 ENOG4105E2S oxidase) subunit II HUO02_RS18005 ENOG4107BMA Transglycosylase associated protein HUO02_RS18015 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUO02_RS18020 ENOG4105WH5 Teichoic acid glycosylation protein HUO02_RS18045 ENOG4107ZXU DSBA oxidoreductase HUO02_RS18050 ENOG4105DBE peroxidase HUO02_RS18055 ENOG410650H (LipO)protein HUO02_RS18060 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUO02_RS18065 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HUO02_RS18070 ENOG4105CMU LysR family (Transcriptional regulator HUO02_RS18075 ENOG4105VAW lrga family HUO02_RS18080 ENOG41067MG lrgb family HUO02_RS18090 ENOG4107TXC Transcriptional regulator HUO02_RS18100 ENOG4105DR4 Methyltransferase HUO02_RS18110 ENOG4105CK1 PTS System HUO02_RS18115 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HUO02_RS18120 ENOG4105X1N Glycosyl transferase family 8 HUO02_RS18130 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HUO02_RS18140 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HUO02_RS18145 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HUO02_RS18150 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HUO02_RS18155 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HUO02_RS18160 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUO02_RS18165 ENOG4105F8D glycoside hydrolase family 4 HUO02_RS18170 ENOG4105VCP PTS System HUO02_RS18175 ENOG4105CK1 PTS System HUO02_RS18180 ENOG4105VZJ PTS System HUO02_RS18185 ENOG4105EMD TRANSCRIPTIONal HUO02_RS18195 ENOG4105DQ5 transport system permease protein HUO02_RS18200 ENOG4105EHG Permease protein HUO02_RS18210 ENOG41082YX Transcriptional regulator, arsr family HUO02_RS18215 ENOG4107R5R arsenical pump membrane protein HUO02_RS18220 ENOG4105VZJ PTS System HUO02_RS18225 ENOG4105VCP PTS System HUO02_RS18230 ENOG4105CK1 PTS System HUO02_RS18235 ENOG4105CS2 ec 3.2.1.21 HUO02_RS18240 ENOG4105EVU fructokinase HUO02_RS18245 ENOG4105DG6 mannose-6-phosphate isomerase HUO02_RS18255 ENOG4105CH6 catalase HUO02_RS18260 ENOG4107QHE Choloylglycine hydrolase HUO02_RS18265 ENOG4105ETS cytosine purines uracil thiamine allantoin HUO02_RS18270 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HUO02_RS18275 ENOG4108JJ8 (ABC) transporter HUO02_RS18280 ENOG4108JJ9 ABC, transporter HUO02_RS18285 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUO02_RS18290 ENOG4105C4M (Ubiquinol oxidase) subunit I HUO02_RS18295 ENOG4105D2K citrate carrier protein HUO02_RS18300 ENOG4107BJW polysaccharide deacetylase HUO02_RS18315 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HUO02_RS18325 ENOG4105CMR udp-glucose 4-epimerase HUO02_RS18330 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HUO02_RS18350 ENOG4105DHI Methyltransferase HUO02_RS18370 ENOG4105CH6 catalase HUO02_RS18375 ENOG4105D4T Citrate transporter HUO02_RS18385 ENOG4105CID antiterminator HUO02_RS18390 ENOG4105DEU major facilitator superfamily HUO02_RS18395 ENOG4105C1J atp-dependent rna helicase HUO02_RS18440 ENOG4108NR7 pectate lyase HUO02_RS18450 ENOG4107YZX Universal stress protein HUO02_RS18455 ENOG4105CS2 ec 3.2.1.21 HUO02_RS18460 ENOG4105C5Y PTS System HUO02_RS18470 ENOG4105M6F mutator MutT protein HUO02_RS18475 ENOG4106Z5D Glycoside Hydrolase Family 43 HUO02_RS18485 ENOG4105C84 Histidine ammonia-lyase HUO02_RS18490 ENOG4105CGP Urocanate hydratase HUO02_RS18495 ENOG4105CI2 imidazolone-5-propionate hydrolase HUO02_RS18500 ENOG4107W25 arginase agmatinase formiminoglutamase HUO02_RS18510 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HUO02_RS18515 ENOG4105D9N nucleoside HUO02_RS18520 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUO02_RS18525 ENOG4107RHR regulatoR HUO02_RS18530 ENOG410667J hydrolase HUO02_RS18560 ENOG4108V5C ABC transporter HUO02_RS18600 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUO02_RS18625 ENOG4105WZ4 isomerase HUO02_RS18630 ENOG4105F0H myo-inositol catabolism protein HUO02_RS18635 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUO02_RS18645 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUO02_RS18655 ENOG4105EDK PfkB domain protein HUO02_RS18665 ENOG4105C26 Dehydrogenase HUO02_RS18675 ENOG4105CPC Aldo Keto reductase HUO02_RS18680 ENOG4107QNK )-transporter HUO02_RS18685 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUO02_RS18690 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUO02_RS18695 ENOG4108S01 response regulator HUO02_RS18700 ENOG4108ZGX Histidine kinase HUO02_RS18705 ENOG4105ECK Fatty Acid Desaturase HUO02_RS18710 ENOG4105ST3 Transcriptional regulator HUO02_RS18715 ENOG4105C26 Dehydrogenase HUO02_RS18720 ENOG4108ITS PQQ enzyme repeat HUO02_RS18730 ENOG4105WAB arsR family transcriptional regulator HUO02_RS18735 ENOG4105F27 Major Facilitator HUO02_RS18740 ENOG41085PJ rdd domain containing protein HUO02_RS18750 ENOG4105D3R alkyl hydroperoxide reductase HUO02_RS18755 ENOG4108JU3 Alkyl hydroperoxide reductase HUO02_RS18760 ENOG4107R3N Filamentation induced by cAMP protein fic HUO02_RS18765 ENOG4105C85 amino acid HUO02_RS18770 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HUO02_RS18775 ENOG4108XHQ (2Fe-2S)-binding domain protein HUO02_RS18795 ENOG4105XRQ Xanthine dehydrogenase accessory factor HUO02_RS18840 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HUO02_RS18860 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HUO02_RS18865 ENOG4105CPC Aldo Keto reductase HUO02_RS18870 ENOG4105WQG acetyltransferase HUO02_RS18880 ENOG41066UZ arginase EC 3.5.3.1 HUO02_RS18885 ENOG4108IQI permease HUO02_RS18890 ENOG4105C8Y Acetylornithine aminotransferase HUO02_RS18895 ENOG4108JUB Transcriptional regulator HUO02_RS18905 ENOG4105C5H ABC transporter HUO02_RS18920 ENOG4105D06 uba thif-type nad fad binding protein HUO02_RS18925 ENOG41062D9 Histidine kinase HUO02_RS18930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUO02_RS18935 ENOG4105C0H protease HUO02_RS18940 ENOG4105Q2H domain protein HUO02_RS18955 ENOG4105BZU Histidine kinase HUO02_RS18960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUO02_RS18985 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUO02_RS18990 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HUO02_RS18995 ENOG4105CDU Replicative dna helicase HUO02_RS19015 ENOG4105EDW glycosyl transferase, family 39 HUO02_RS19030 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUO02_RS19035 ENOG4105CPK Glycosyl transferase (Group 1 HUO02_RS19055 ENOG4105BZR domain protein HUO02_RS19060 ENOG4108XMW Membrane HUO02_RS19075 ENOG4105KVH Transcriptional regulator HUO02_RS19080 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HUO02_RS19085 ENOG4108UZ3 Transporter HUO02_RS19090 ENOG4105EDQ levansucrase EC 2.4.1.10 HUO02_RS19095 ENOG4108HKT sucrose-6-phosphate hydrolase HUO02_RS19100 ENOG4107XBN GntR Family Transcriptional Regulator HUO02_RS19115 ENOG4107V2S Transcriptional regulator HUO02_RS19120 ENOG4108VP3 Lysine exporter protein (LysE YggA) HUO02_RS19125 ENOG4105D94 Major Facilitator Superfamily HUO02_RS19130 ENOG4107RSM transcriptional regulator HUO02_RS19140 ENOG4108TVJ Nitroreductase HUO02_RS19145 ENOG4105FS7 Transcriptional regulator HUO02_RS19155 ENOG4108U05 Transcriptional regulator HUO02_RS19160 ENOG41082BV acetyltransferase HUO02_RS19170 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUO02_RS19175 ENOG4105CMU LysR family (Transcriptional regulator HUO02_RS19180 ENOG4105DTD Dehydrogenase HUO02_RS19190 ENOG4105C7Z Conserved Protein HUO02_RS19210 ENOG4105D9P serine threonine protein kinase HUO02_RS19215 ENOG4105C7Z Conserved Protein HUO02_RS19220 ENOG4107FCW Abortive infection protein HUO02_RS19230 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HUO02_RS19240 ENOG4105CGK Exodeoxyribonuclease III HUO02_RS19245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUO02_RS19255 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUO02_RS19260 ENOG4108UUM single-stranded DNA-binding protein HUO02_RS19265 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HUO02_RS19270 ENOG4105C3G gtp-binding protein HUO02_RS19275 ENOG4108J2R molybdopterin oxidoreductase HUO02_RS19280 ENOG4105VDK protein, conserved in bacteria HUO02_RS19295 ENOG4108ZDA Sporulation protein YyaC HUO02_RS19300 ENOG4105FA0 parb-like partition protein HUO02_RS19305 ENOG4107QJE Chromosome Partitioning Protein HUO02_RS19320 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUO02_RS19325 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HUO02_RS19340 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)