locus-tag	class	description
HUO02_RS00010	COG0592	DNA-directed DNA polymerase activity
HUO02_RS00015	COG2501	S4 domain
HUO02_RS00030	COG0187	DNA topoisomerase II activity
HUO02_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUO02_RS00070	COG0516	GMP reductase activity
HUO02_RS00070	COG0517	IMP dehydrogenase activity
HUO02_RS00075	COG1686	Belongs to the peptidase S11 family
HUO02_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
HUO02_RS00105	COG1428	Deoxynucleoside kinase
HUO02_RS00110	COG1428	Deoxynucleoside kinase
HUO02_RS00115	COG3858	chitin binding
HUO02_RS00115	COG1388	LysM domain
HUO02_RS00120	COG1335	isochorismatase
HUO02_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HUO02_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUO02_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUO02_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HUO02_RS00195	COG3853	Toxic anion resistance protein (TelA)
HUO02_RS00200	COG1982	Orn Lys Arg decarboxylase major
HUO02_RS00210	COG3870	Protein conserved in bacteria
HUO02_RS00215	COG1728	Protein conserved in bacteria
HUO02_RS00220	COG0470	DNA polymerase III
HUO02_RS00225	COG1774	PSP1 C-terminal conserved region
HUO02_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUO02_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUO02_RS00250	COG2002	toxin-antitoxin pair type II binding
HUO02_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO02_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO02_RS00260	COG0084	hydrolase, TatD family'
HUO02_RS00265	COG3584	3D domain protein
HUO02_RS00265	COG3583	domain protein
HUO02_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUO02_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUO02_RS00285	COG4466	Protein conserved in bacteria
HUO02_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO02_RS00305	COG0251	oxidation-reduction process
HUO02_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUO02_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUO02_RS00345	COG2002	toxin-antitoxin pair type II binding
HUO02_RS00350	COG2244	polysaccharide biosynthetic process
HUO02_RS00355	COG3956	TIGRFAM MazG family protein
HUO02_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUO02_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HUO02_RS00380	COG1098	S1 RNA binding domain
HUO02_RS00395	COG2208	phosphoserine phosphatase activity
HUO02_RS00400	COG2304	oxidoreductase activity
HUO02_RS00405	COG0515	serine threonine protein kinase
HUO02_RS00410	COG0037	tRNA processing
HUO02_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUO02_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO02_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO02_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUO02_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HUO02_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUO02_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUO02_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUO02_RS00475	COG1396	sequence-specific DNA binding
HUO02_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO02_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUO02_RS00565	COG4463	regulation of RNA biosynthetic process
HUO02_RS00570	COG3880	PFAM UvrB UvrC protein
HUO02_RS00580	COG0542	response to heat
HUO02_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUO02_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUO02_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HUO02_RS00615	COG1045	serine acetyltransferase
HUO02_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUO02_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO02_RS00635	COG3688	RNA-binding protein containing a PIN domain
HUO02_RS00640	COG1595	DNA-templated transcription, initiation
HUO02_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUO02_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HUO02_RS00680	COG2813	Specifically methylates the guanine in position
HUO02_RS00695	COG1358	cellular component organization or biogenesis
HUO02_RS00720	COG0596	Alpha beta hydrolase
HUO02_RS00830	COG0201	protein transport
HUO02_RS00840	COG0024	Methionine aminopeptidase
HUO02_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUO02_RS00875	COG1122	ATPase activity
HUO02_RS00880	COG1122	ATPase activity
HUO02_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUO02_RS00905	COG2226	methyltransferase
HUO02_RS00910	COG2318	DinB family
HUO02_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS00925	COG0489	protein tyrosine kinase activity
HUO02_RS00935	COG2194	sulfuric ester hydrolase activity
HUO02_RS00940	COG0726	polysaccharide deacetylase
HUO02_RS01000	COG0738	Major facilitator superfamily
HUO02_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
HUO02_RS01025	COG0385	Bile acid
HUO02_RS01030	COG2819	hydrolase of the alpha beta superfamily
HUO02_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO02_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO02_RS01050	COG2207	Transcriptional regulator
HUO02_RS01055	COG3876	Protein conserved in bacteria
HUO02_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
HUO02_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO02_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS01070	COG1263	PTS System
HUO02_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO02_RS01085	COG1683	Conserved Protein
HUO02_RS01115	COG1595	DNA-templated transcription, initiation
HUO02_RS01120	COG5662	AntiSigma factor
HUO02_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUO02_RS01130	COG4856	YbbR-like protein
HUO02_RS01170	COG2205	protein histidine kinase activity
HUO02_RS01180	COG1136	(ABC) transporter
HUO02_RS01185	COG0577	efflux transmembrane transporter activity
HUO02_RS01205	COG1346	cytolysis
HUO02_RS01210	COG1380	Effector of murein hydrolase LrgA
HUO02_RS01215	COG1846	Transcriptional regulator
HUO02_RS01220	COG1113	amino acid transport
HUO02_RS01225	COG1011	Hydrolase
HUO02_RS01230	COG4585	Histidine kinase
HUO02_RS01235	COG2197	response regulator
HUO02_RS01240	COG1131	(ABC) transporter
HUO02_RS01280	COG0531	amino acid
HUO02_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
HUO02_RS01300	COG2271	Major facilitator Superfamily
HUO02_RS01310	COG2368	4-hydroxyphenylacetate
HUO02_RS01320	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS01335	COG0371	Dehydrogenase
HUO02_RS01345	COG1183	phosphatidylcholine synthase activity
HUO02_RS01350	COG0586	Pfam SNARE associated Golgi protein
HUO02_RS01355	COG0688	phosphatidylethanolamine metabolic process
HUO02_RS01370	COG1301	dicarboxylic acid transport
HUO02_RS01375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS01380	COG0833	amino acid
HUO02_RS01385	COG2040	homocysteine
HUO02_RS01390	COG1115	amino acid carrier protein
HUO02_RS01395	COG2066	Belongs to the glutaminase family
HUO02_RS01400	COG4191	Histidine kinase
HUO02_RS01405	COG0784	Response regulator, receiver
HUO02_RS01425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUO02_RS01430	COG0778	Nitroreductase
HUO02_RS01435	COG0346	lactoylglutathione lyase activity
HUO02_RS01440	COG2259	Doxx family
HUO02_RS01445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS01455	COG3773	Cell wall hydrolase
HUO02_RS01460	COG3540	Alkaline phosphatase
HUO02_RS01465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUO02_RS01470	COG0805	protein transport
HUO02_RS01480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUO02_RS01485	COG0477	Major facilitator Superfamily
HUO02_RS01490	COG1309	transcriptional regulator
HUO02_RS01495	COG0252	asparaginase activity
HUO02_RS01500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUO02_RS01505	COG3012	SEC-C Motif Domain Protein
HUO02_RS01505	COG1405	negative regulation of cell septum assembly
HUO02_RS01510	COG0667	Aldo Keto reductase
HUO02_RS01520	COG1595	DNA-templated transcription, initiation
HUO02_RS01525	COG1595	DNA-templated transcription, initiation
HUO02_RS01530	COG1876	peptidase activity
HUO02_RS01535	COG0457	Tetratricopeptide repeat
HUO02_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS01545	COG0366	Alpha amylase catalytic
HUO02_RS01550	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUO02_RS01555	COG1121	(ABC) transporter
HUO02_RS01560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUO02_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS01570	COG2310	stress, protein
HUO02_RS01575	COG2310	stress, protein
HUO02_RS01580	COG2310	stress, protein
HUO02_RS01585	COG0861	Integral membrane protein TerC family
HUO02_RS01595	COG3853	Toxic anion resistance protein (TelA)
HUO02_RS01600	COG0477	Major facilitator Superfamily
HUO02_RS01605	COG0517	IMP dehydrogenase activity
HUO02_RS01605	COG4175	Glycine betaine
HUO02_RS01610	COG4176	ABC-type proline glycine betaine transport system permease component
HUO02_RS01615	COG2113	Glycine betaine
HUO02_RS01620	COG1473	amidohydrolase
HUO02_RS01625	COG1288	antiporter activity
HUO02_RS01635	COG0366	Alpha amylase catalytic
HUO02_RS01645	COG2814	Major facilitator Superfamily
HUO02_RS01650	COG1846	Transcriptional regulator
HUO02_RS01655	COG1280	lysine exporter protein (LysE YggA)
HUO02_RS01660	COG3403	YqcI/YcgG family
HUO02_RS01665	COG1113	amino acid transport
HUO02_RS01670	COG3665	Urea carboxylase-associated protein
HUO02_RS01685	COG1660	Displays ATPase and GTPase activities
HUO02_RS01690	COG1082	Xylose isomerase domain protein TIM barrel
HUO02_RS01695	COG2271	Major facilitator Superfamily
HUO02_RS01700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUO02_RS01705	COG3458	cephalosporin-C deacetylase activity
HUO02_RS01710	COG3541	Predicted nucleotidyltransferase
HUO02_RS01715	COG0506	proline dehydrogenase activity
HUO02_RS01720	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS01725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO02_RS01730	COG2508	Transcriptional regulator
HUO02_RS01740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUO02_RS01740	COG1587	Uroporphyrinogen-III synthase
HUO02_RS01745	COG2146	nitrite reductase [NAD(P)H] activity
HUO02_RS01750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO02_RS01755	COG0243	molybdopterin cofactor binding
HUO02_RS01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO02_RS01765	COG2223	nitrite transmembrane transporter activity
HUO02_RS01770	COG0523	cobalamin synthesis protein
HUO02_RS01775	COG1063	alcohol dehydrogenase
HUO02_RS01780	COG1714	RDD family
HUO02_RS01790	COG2723	6-phospho-beta-galactosidase activity
HUO02_RS01800	COG3209	COG3209 Rhs family protein
HUO02_RS01805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUO02_RS01810	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HUO02_RS01815	COG1733	regulation of RNA biosynthetic process
HUO02_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS01825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS01835	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUO02_RS01850	COG0697	spore germination
HUO02_RS01855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO02_RS01865	COG2364	Membrane
HUO02_RS01870	COG1126	abc transporter atp-binding protein
HUO02_RS01875	COG0765	amino acid transport
HUO02_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO02_RS01885	COG0583	DNA-binding transcription factor activity
HUO02_RS01890	COG0163	prenyltransferase activity
HUO02_RS01895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUO02_RS01910	COG3104	oligopeptide transport
HUO02_RS01915	COG5434	Belongs to the glycosyl hydrolase 28 family
HUO02_RS01925	COG0697	spore germination
HUO02_RS01935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUO02_RS01940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS01945	COG0456	acetyltransferase
HUO02_RS01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO02_RS01955	COG0765	amino acid transport
HUO02_RS01960	COG1126	abc transporter atp-binding protein
HUO02_RS01965	COG1473	amidohydrolase
HUO02_RS01970	COG2079	MmgE PrpD family protein
HUO02_RS01975	COG1136	(ABC) transporter
HUO02_RS01980	COG0577	efflux transmembrane transporter activity
HUO02_RS01985	COG0745	RESPONSE REGULATOR receiver
HUO02_RS01990	COG5002	protein histidine kinase activity
HUO02_RS01990	COG3850	Histidine kinase
HUO02_RS01995	COG0457	Tetratricopeptide repeat
HUO02_RS02010	COG0527	aspartate kinase activity
HUO02_RS02015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS02020	COG4605	iron ion homeostasis
HUO02_RS02025	COG4604	ABC transporter, ATP-binding protein
HUO02_RS02030	COG4607	ABC-type enterochelin transport system periplasmic component
HUO02_RS02035	COG2814	Major facilitator Superfamily
HUO02_RS02040	COG1309	transcriptional regulator
HUO02_RS02045	COG0778	Nitroreductase
HUO02_RS02050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HUO02_RS02055	COG0640	Transcriptional regulator
HUO02_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO02_RS02065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS02070	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS02075	COG4975	Glucose uptake
HUO02_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS02085	COG4549	nuclear export factor GLE1
HUO02_RS02090	COG2372	response to copper ion
HUO02_RS02090	COG1276	copper resistance
HUO02_RS02095	COG1349	DNA-binding transcription factor activity
HUO02_RS02105	COG2213	PTS system mannitol-specific
HUO02_RS02110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS02120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUO02_RS02130	COG0561	phosphatase activity
HUO02_RS02140	COG1914	H( )-stimulated, divalent metal cation uptake system
HUO02_RS02150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUO02_RS02155	COG1984	allophanate hydrolase subunit 2
HUO02_RS02160	COG1414	Transcriptional regulator
HUO02_RS02165	COG2755	lipolytic protein G-D-S-L family
HUO02_RS02175	COG2329	Antibiotic biosynthesis monooxygenase
HUO02_RS02180	COG0768	penicillin binding
HUO02_RS02185	COG4989	oxidoreductase activity
HUO02_RS02190	COG3711	transcriptional antiterminator
HUO02_RS02195	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS02205	COG1917	Cupin 2, conserved barrel domain protein
HUO02_RS02210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO02_RS02215	COG3871	stress protein (general stress protein 26)
HUO02_RS02225	COG2814	Major facilitator Superfamily
HUO02_RS02230	COG1522	sequence-specific DNA binding
HUO02_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO02_RS02235	COG0551	DNA topoisomerase type I activity
HUO02_RS02240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUO02_RS02245	COG3706	GGDEF domain
HUO02_RS02250	COG5298	Protein conserved in bacteria
HUO02_RS02255	COG1215	transferase activity, transferring glycosyl groups
HUO02_RS02265	COG0531	amino acid
HUO02_RS02270	COG0494	nUDIX hydrolase
HUO02_RS02275	COG0028	Belongs to the TPP enzyme family
HUO02_RS02305	COG0457	Tetratricopeptide repeat
HUO02_RS02325	COG1914	H( )-stimulated, divalent metal cation uptake system
HUO02_RS02335	COG4876	unkown
HUO02_RS02345	COG2076	Multidrug Resistance protein
HUO02_RS02350	COG2217	Heavy metal translocating P-type atpase
HUO02_RS02355	COG3729	General stress protein
HUO02_RS02360	COG0662	Cupin 2, conserved barrel domain protein
HUO02_RS02365	COG2329	Antibiotic biosynthesis monooxygenase
HUO02_RS02370	COG3546	catalase activity
HUO02_RS02375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUO02_RS02380	COG3290	protein histidine kinase activity
HUO02_RS02385	COG4565	transcriptional regulatory protein
HUO02_RS02390	COG1301	dicarboxylic acid transport
HUO02_RS02395	COG0628	permease
HUO02_RS02400	COG1131	(ABC) transporter
HUO02_RS02405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HUO02_RS02415	COG1960	acyl-CoA dehydrogenase activity
HUO02_RS02435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUO02_RS02450	COG0513	Belongs to the DEAD box helicase family
HUO02_RS02455	COG3402	PFAM membrane-flanked domain
HUO02_RS02460	COG3428	Bacterial PH domain
HUO02_RS02465	COG0705	Rhomboid family
HUO02_RS02475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUO02_RS02480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUO02_RS02485	COG0864	Transcriptional regulator
HUO02_RS02490	COG2337	Toxic component of a toxin-antitoxin (TA) module
HUO02_RS02495	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS02500	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS02505	COG2172	sigma factor antagonist activity
HUO02_RS02510	COG2208	phosphoserine phosphatase activity
HUO02_RS02515	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS02525	COG1191	sigma factor activity
HUO02_RS02530	COG2208	phosphoserine phosphatase activity
HUO02_RS02535	COG2183	response to ionizing radiation
HUO02_RS02590	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUO02_RS02600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUO02_RS02605	COG1522	sequence-specific DNA binding
HUO02_RS02620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO02_RS02625	COG0477	Major facilitator Superfamily
HUO02_RS02630	COG1846	Transcriptional regulator
HUO02_RS02640	COG2030	dehydratase
HUO02_RS02655	COG1959	2 iron, 2 sulfur cluster binding
HUO02_RS02660	COG2910	NAD(P)H-binding
HUO02_RS02665	COG1309	transcriptional regulator
HUO02_RS02670	COG0300	oxidoreductase activity
HUO02_RS02680	COG0604	alcohol dehydrogenase
HUO02_RS02690	COG3239	Fatty acid desaturase
HUO02_RS02700	COG1278	Cold shock
HUO02_RS02705	COG1329	Transcriptional regulator
HUO02_RS02710	COG1937	Protein conserved in bacteria
HUO02_RS02715	COG2210	Belongs to the sulfur carrier protein TusA family
HUO02_RS02725	COG0425	Belongs to the sulfur carrier protein TusA family
HUO02_RS02725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO02_RS02730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS02730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO02_RS02735	COG0425	Belongs to the sulfur carrier protein TusA family
HUO02_RS02740	COG0730	response to heat
HUO02_RS02745	COG1794	racemase activity, acting on amino acids and derivatives
HUO02_RS02760	COG1846	Transcriptional regulator
HUO02_RS02760	COG0456	acetyltransferase
HUO02_RS02765	COG2271	Major facilitator Superfamily
HUO02_RS02770	COG3621	Patatin-like phospholipase
HUO02_RS02780	COG0662	Cupin 2, conserved barrel domain protein
HUO02_RS02795	COG0277	FAD linked oxidase domain protein
HUO02_RS02820	COG0662	Cupin 2, conserved barrel domain protein
HUO02_RS02830	COG2318	DinB family
HUO02_RS02835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUO02_RS02870	COG0351	phosphomethylpyrimidine kinase
HUO02_RS02885	COG1064	alcohol dehydrogenase
HUO02_RS02890	COG0789	Transcriptional regulator
HUO02_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO02_RS02930	COG2814	Major facilitator Superfamily
HUO02_RS02935	COG1309	transcriptional regulator
HUO02_RS02940	COG0697	spore germination
HUO02_RS02945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO02_RS02950	COG5577	PFAM Coat F domain
HUO02_RS02960	COG1063	alcohol dehydrogenase
HUO02_RS02965	COG5577	PFAM Coat F domain
HUO02_RS02975	COG4585	Histidine kinase
HUO02_RS02980	COG2197	response regulator
HUO02_RS02985	COG2409	Drug exporters of the RND superfamily
HUO02_RS02990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUO02_RS03000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO02_RS03005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS03015	COG2814	Major facilitator Superfamily
HUO02_RS03020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO02_RS03030	COG0730	response to heat
HUO02_RS03035	COG0456	acetyltransferase
HUO02_RS03040	COG0789	Transcriptional regulator
HUO02_RS03040	COG4978	Transcriptional regulator
HUO02_RS03045	COG0697	spore germination
HUO02_RS03050	COG1051	belongs to the nudix hydrolase family
HUO02_RS03055	COG2226	methyltransferase
HUO02_RS03065	COG1802	Transcriptional regulator
HUO02_RS03070	COG1819	glycosyl
HUO02_RS03085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO02_RS03095	COG1388	LysM domain
HUO02_RS03100	COG2814	Major facilitator Superfamily
HUO02_RS03105	COG2188	Transcriptional regulator
HUO02_RS03110	COG2186	Transcriptional regulator
HUO02_RS03115	COG2807	transmembrane transport
HUO02_RS03120	COG2076	Multidrug Resistance protein
HUO02_RS03125	COG2076	Multidrug Resistance protein
HUO02_RS03130	COG1309	transcriptional regulator
HUO02_RS03135	COG0531	amino acid
HUO02_RS03145	COG3832	glyoxalase III activity
HUO02_RS03150	COG0604	alcohol dehydrogenase
HUO02_RS03155	COG2814	Major facilitator Superfamily
HUO02_RS03195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUO02_RS03200	COG0802	atpase or kinase
HUO02_RS03205	COG1214	PFAM Peptidase M22, glycoprotease
HUO02_RS03210	COG0456	acetyltransferase
HUO02_RS03215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUO02_RS03220	COG0488	(ABC) transporter
HUO02_RS03235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUO02_RS03240	COG0805	protein transport
HUO02_RS03250	COG1266	CAAX protease self-immunity
HUO02_RS03265	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS03285	COG0457	Tetratricopeptide repeat
HUO02_RS03290	COG1063	alcohol dehydrogenase
HUO02_RS03295	COG2211	Major facilitator Superfamily
HUO02_RS03300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO02_RS03310	COG1842	Phage shock protein A
HUO02_RS03315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUO02_RS03320	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUO02_RS03325	COG4260	virion core protein, lumpy skin disease virus
HUO02_RS03330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUO02_RS03330	COG2755	lipolytic protein G-D-S-L family
HUO02_RS03340	COG1595	DNA-templated transcription, initiation
HUO02_RS03345	COG1063	alcohol dehydrogenase
HUO02_RS03350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUO02_RS03355	COG0823	Involved in the tonB-independent uptake of proteins
HUO02_RS03370	COG2132	Multicopper oxidase
HUO02_RS03375	COG1113	amino acid transport
HUO02_RS03380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUO02_RS03385	COG0714	Associated with various cellular activities
HUO02_RS03390	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HUO02_RS03395	COG1305	Transglutaminase-like
HUO02_RS03415	COG2252	PERMEase
HUO02_RS03420	COG3064	Membrane
HUO02_RS03440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUO02_RS03445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUO02_RS03450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUO02_RS03455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUO02_RS03460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUO02_RS03475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUO02_RS03485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUO02_RS03490	COG0138	bifunctional purine biosynthesis protein purh
HUO02_RS03495	COG0151	Belongs to the GarS family
HUO02_RS03505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUO02_RS03510	COG1470	cell adhesion involved in biofilm formation
HUO02_RS03515	COG4496	protein, YerC YecD
HUO02_RS03520	COG0069	glutamate synthase activity
HUO02_RS03530	COG0210	DNA helicase
HUO02_RS03540	COG4851	CamS sex pheromone cAM373 precursor
HUO02_RS03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUO02_RS03550	COG1285	pathogenesis
HUO02_RS03555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO02_RS03575	COG1309	transcriptional regulator
HUO02_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO02_RS03585	COG1597	lipid kinase activity
HUO02_RS03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUO02_RS03595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUO02_RS03605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUO02_RS03635	COG5444	nuclease activity
HUO02_RS03660	COG3546	catalase activity
HUO02_RS03665	COG0454	-acetyltransferase
HUO02_RS03675	COG2323	membrane
HUO02_RS03680	COG2329	Antibiotic biosynthesis monooxygenase
HUO02_RS03685	COG0346	lactoylglutathione lyase activity
HUO02_RS03690	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS03695	COG5583	Uncharacterized small protein (DUF2292)
HUO02_RS03700	COG0196	riboflavin kinase activity
HUO02_RS03705	COG0670	Belongs to the BI1 family
HUO02_RS03710	COG1846	Transcriptional regulator
HUO02_RS03715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUO02_RS03725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUO02_RS03725	COG2124	cytochrome p450
HUO02_RS03740	COG1131	(ABC) transporter
HUO02_RS03785	COG4106	trans-aconitate 2-methyltransferase activity
HUO02_RS03790	COG1368	sulfuric ester hydrolase activity
HUO02_RS03795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUO02_RS03800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS03805	COG1442	glycosyl transferase family 8
HUO02_RS03810	COG1216	Glycosyl transferase, family 2
HUO02_RS03815	COG1442	glycosyl transferase family 8
HUO02_RS03820	COG2223	nitrite transmembrane transporter activity
HUO02_RS03825	COG0531	amino acid
HUO02_RS03830	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS03835	COG0840	transmembrane signaling receptor activity
HUO02_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS03845	COG0457	Tetratricopeptide repeat
HUO02_RS03845	COG0463	Glycosyl transferase, family 2
HUO02_RS03850	COG0488	(ABC) transporter
HUO02_RS03855	COG0789	Transcriptional regulator
HUO02_RS03860	COG2814	Major facilitator Superfamily
HUO02_RS03865	COG0488	(ABC) transporter
HUO02_RS03870	COG0513	Belongs to the DEAD box helicase family
HUO02_RS03880	COG2130	NADP-dependent
HUO02_RS03895	COG3866	Pectate lyase
HUO02_RS03900	COG0471	metal ion transport
HUO02_RS03925	COG3290	protein histidine kinase activity
HUO02_RS03930	COG4565	transcriptional regulatory protein
HUO02_RS03935	COG3181	Tripartite tricarboxylate transporter family receptor
HUO02_RS03940	COG2851	Citrate transporter
HUO02_RS03945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS03950	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HUO02_RS03960	COG2258	MOSC domain
HUO02_RS03980	COG0024	Methionine aminopeptidase
HUO02_RS03985	COG1263	PTS System
HUO02_RS03985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS03995	COG1368	sulfuric ester hydrolase activity
HUO02_RS04005	COG0071	Belongs to the small heat shock protein (HSP20) family
HUO02_RS04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS04020	COG1263	PTS System
HUO02_RS04025	COG0366	Alpha amylase catalytic
HUO02_RS04030	COG2188	Transcriptional regulator
HUO02_RS04035	COG0778	Nitroreductase
HUO02_RS04050	COG0737	Belongs to the 5'-nucleotidase family
HUO02_RS04055	COG0693	protein deglycase activity
HUO02_RS04060	COG1609	Transcriptional regulator
HUO02_RS04075	COG2814	Major facilitator Superfamily
HUO02_RS04085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUO02_RS04090	COG4980	gas vesicle protein
HUO02_RS04095	COG1295	ribonuclease BN
HUO02_RS04100	COG0477	Major facilitator Superfamily
HUO02_RS04105	COG0387	Pfam Sodium calcium exchanger
HUO02_RS04115	COG0668	transmembrane transport
HUO02_RS04120	COG0535	radical SAM domain protein
HUO02_RS04130	COG0726	polysaccharide deacetylase
HUO02_RS04135	COG2084	Dehydrogenase
HUO02_RS04145	COG0598	Magnesium transport protein CorA
HUO02_RS04150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUO02_RS04155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUO02_RS04165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO02_RS04170	COG4637	Psort location Cytoplasmic, score
HUO02_RS04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUO02_RS04180	COG0022	dehydrogenase e1 component
HUO02_RS04185	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO02_RS04190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO02_RS04195	COG3284	Transcriptional regulator
HUO02_RS04205	COG1486	melibiose metabolic process
HUO02_RS04210	COG1737	Transcriptional regulator
HUO02_RS04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS04215	COG1263	PTS System
HUO02_RS04220	COG5434	Belongs to the glycosyl hydrolase 28 family
HUO02_RS04225	COG1132	(ABC) transporter
HUO02_RS04230	COG1132	(ABC) transporter
HUO02_RS04235	COG2259	Doxx family
HUO02_RS04240	COG2514	catechol 2,3-dioxygenase activity
HUO02_RS04250	COG1695	Transcriptional regulator
HUO02_RS04255	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUO02_RS04260	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HUO02_RS04265	COG0574	Belongs to the PEP-utilizing enzyme family
HUO02_RS04265	COG3848	Pyruvate phosphate dikinase
HUO02_RS04270	COG2732	(Barnase) inhibitor
HUO02_RS04275	COG2318	DinB family
HUO02_RS04280	COG2814	Major facilitator Superfamily
HUO02_RS04285	COG1846	Transcriptional regulator
HUO02_RS04290	COG0392	lysyltransferase activity
HUO02_RS04290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUO02_RS04295	COG0384	phenazine biosynthesis protein PhzF
HUO02_RS04300	COG0778	Nitroreductase
HUO02_RS04315	COG1090	epimerase
HUO02_RS04330	COG2814	Major facilitator Superfamily
HUO02_RS04340	COG3591	Belongs to the peptidase S1B family
HUO02_RS04355	COG3103	Sh3 type 3 domain protein
HUO02_RS04360	COG5658	integral membrane protein
HUO02_RS04365	COG0596	Alpha beta hydrolase
HUO02_RS04370	COG0463	Glycosyl transferase, family 2
HUO02_RS04375	COG4485	Bacterial membrane protein, YfhO
HUO02_RS04380	COG1988	membrane-bound metal-dependent
HUO02_RS04385	COG1194	a g-specific adenine glycosylase
HUO02_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS04415	COG1132	(ABC) transporter
HUO02_RS04420	COG4129	membrane
HUO02_RS04430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUO02_RS04435	COG0735	belongs to the Fur family
HUO02_RS04545	COG1757	Na H antiporter
HUO02_RS04550	COG3340	Belongs to the peptidase S51 family
HUO02_RS04560	COG0277	FAD linked oxidase domain protein
HUO02_RS04575	COG0753	catalase activity
HUO02_RS04585	COG1116	anion transmembrane transporter activity
HUO02_RS04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUO02_RS04595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUO02_RS04615	COG1476	TRANSCRIPTIONal
HUO02_RS04625	COG3382	B3 4 domain protein
HUO02_RS04630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUO02_RS04640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUO02_RS04645	COG0789	Transcriptional regulator
HUO02_RS04650	COG1664	Polymer-forming cytoskeletal
HUO02_RS04655	COG1664	Polymer-forming cytoskeletal
HUO02_RS04660	COG2766	serine protein kinase
HUO02_RS04670	COG1846	Transcriptional regulator
HUO02_RS04675	COG1566	PFAM secretion protein HlyD family protein
HUO02_RS04680	COG2814	Major facilitator Superfamily
HUO02_RS04685	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUO02_RS04700	COG1725	Transcriptional regulator
HUO02_RS04705	COG1131	(ABC) transporter
HUO02_RS04710	COG1131	(ABC) transporter
HUO02_RS04715	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HUO02_RS04720	COG1278	Cold shock
HUO02_RS04725	COG1464	Belongs to the NlpA lipoprotein family
HUO02_RS04730	COG3706	GGDEF domain
HUO02_RS04735	COG1823	symporter activity
HUO02_RS04755	COG5577	PFAM Coat F domain
HUO02_RS04765	COG3764	Sortase (surface protein transpeptidase)
HUO02_RS04770	COG0564	pseudouridine synthase activity
HUO02_RS04780	COG0517	IMP dehydrogenase activity
HUO02_RS04785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO02_RS04790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUO02_RS04790	COG3153	acetyltransferase
HUO02_RS04795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUO02_RS04800	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HUO02_RS04805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUO02_RS04815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUO02_RS04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO02_RS04825	COG4585	Histidine kinase
HUO02_RS04825	COG2203	Gaf domain
HUO02_RS04830	COG2197	response regulator
HUO02_RS04835	COG0431	NADPH-dependent FMN reductase
HUO02_RS04850	COG1388	LysM domain
HUO02_RS04850	COG0791	NLP P60 protein
HUO02_RS04855	COG1959	2 iron, 2 sulfur cluster binding
HUO02_RS04860	COG0668	transmembrane transport
HUO02_RS04865	COG2719	SpoVR family
HUO02_RS04870	COG1785	Belongs to the alkaline phosphatase family
HUO02_RS04875	COG0791	NLP P60 protein
HUO02_RS04875	COG1388	LysM domain
HUO02_RS04880	COG0583	DNA-binding transcription factor activity
HUO02_RS04885	COG0372	Belongs to the citrate synthase family
HUO02_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS04895	COG0531	amino acid
HUO02_RS04900	COG0733	neurotransmitter:sodium symporter activity
HUO02_RS04915	COG1595	DNA-templated transcription, initiation
HUO02_RS04920	COG0204	Acyl-transferase
HUO02_RS04925	COG1253	flavin adenine dinucleotide binding
HUO02_RS04930	COG0789	Transcriptional regulator
HUO02_RS04935	COG0436	Aminotransferase
HUO02_RS04940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO02_RS04945	COG1253	flavin adenine dinucleotide binding
HUO02_RS04950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUO02_RS04955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUO02_RS04960	COG0584	glycerophosphoryl diester phosphodiesterase
HUO02_RS04970	COG0668	transmembrane transport
HUO02_RS04975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUO02_RS04980	COG0726	polysaccharide deacetylase
HUO02_RS04985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS04990	COG3226	Transcriptional regulator
HUO02_RS05000	COG0589	response to stress
HUO02_RS05005	COG1132	(ABC) transporter
HUO02_RS05010	COG1132	(ABC) transporter
HUO02_RS05015	COG0702	epimerase
HUO02_RS05030	COG0189	ligase activity
HUO02_RS05035	COG0189	ligase activity
HUO02_RS05050	COG4335	DNA alkylation repair
HUO02_RS05055	COG0561	phosphatase activity
HUO02_RS05060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUO02_RS05070	COG0475	glutathione-regulated potassium exporter activity
HUO02_RS05075	COG0490	domain, Protein
HUO02_RS05085	COG1024	Enoyl-CoA hydratase
HUO02_RS05095	COG4152	abc transporter atp-binding protein
HUO02_RS05100	COG1668	transmembrane transport
HUO02_RS05105	COG0420	3'-5' exonuclease activity
HUO02_RS05110	COG4717	serine-type aminopeptidase activity
HUO02_RS05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO02_RS05160	COG4980	gas vesicle protein
HUO02_RS05175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUO02_RS05180	COG0537	adenosine 5'-monophosphoramidase activity
HUO02_RS05185	COG1131	(ABC) transporter
HUO02_RS05190	COG4473	ABC transporter
HUO02_RS05200	COG1473	amidohydrolase
HUO02_RS05205	COG3069	C4-dicarboxylate transmembrane transporter activity
HUO02_RS05210	COG2329	Antibiotic biosynthesis monooxygenase
HUO02_RS05215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO02_RS05235	COG1309	transcriptional regulator
HUO02_RS05240	COG1511	domain protein
HUO02_RS05245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO02_RS05255	COG1363	Peptidase, m42
HUO02_RS05260	COG1301	dicarboxylic acid transport
HUO02_RS05270	COG1234	tRNA 3'-trailer cleavage
HUO02_RS05275	COG0095	Lipoate-protein ligase
HUO02_RS05280	COG0702	epimerase
HUO02_RS05285	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS05295	COG0501	Belongs to the peptidase M48B family
HUO02_RS05330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUO02_RS05335	COG0406	alpha-ribazole phosphatase activity
HUO02_RS05340	COG0183	Belongs to the thiolase family
HUO02_RS05345	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS05350	COG1268	BioY protein
HUO02_RS05355	COG0840	transmembrane signaling receptor activity
HUO02_RS05360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO02_RS05360	COG0723	plastoquinol--plastocyanin reductase activity
HUO02_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS05375	COG4903	ComK protein
HUO02_RS05385	COG5646	InterPro IPR014922
HUO02_RS05410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO02_RS05425	COG0398	Pfam SNARE associated Golgi protein
HUO02_RS05430	COG0681	Belongs to the peptidase S26 family
HUO02_RS05435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUO02_RS05440	COG1846	Transcriptional regulator
HUO02_RS05445	COG3180	Ammonia monooxygenase
HUO02_RS05450	COG2814	Major facilitator Superfamily
HUO02_RS05460	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HUO02_RS05465	COG2323	membrane
HUO02_RS05480	COG0420	3'-5' exonuclease activity
HUO02_RS05485	COG0419	ATPase involved in DNA repair
HUO02_RS05490	COG1403	HNH endonuclease
HUO02_RS05530	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUO02_RS05550	COG0367	asparagine synthase
HUO02_RS05555	COG1562	ergosterol biosynthetic process
HUO02_RS05560	COG0534	Mate efflux family protein
HUO02_RS05565	COG1917	Cupin 2, conserved barrel domain protein
HUO02_RS05565	COG2207	Transcriptional regulator
HUO02_RS05570	COG2318	DinB family
HUO02_RS05575	COG1357	PFAM Pentapeptide repeats (8 copies)
HUO02_RS05580	COG2153	protein acetylation
HUO02_RS05585	COG0646	methionine synthase
HUO02_RS05585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUO02_RS05595	COG2996	Protein conserved in bacteria
HUO02_RS05605	COG0840	transmembrane signaling receptor activity
HUO02_RS05610	COG2124	cytochrome p450
HUO02_RS05620	COG1307	EDD domain protein, DegV family
HUO02_RS05625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS05645	COG0561	phosphatase activity
HUO02_RS05650	COG1073	alpha beta
HUO02_RS05655	COG2151	metal-sulfur cluster biosynthetic enzyme
HUO02_RS05665	COG0277	FAD linked oxidase domain protein
HUO02_RS05670	COG2271	Major facilitator Superfamily
HUO02_RS05680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUO02_RS05690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUO02_RS05695	COG0505	Belongs to the CarA family
HUO02_RS05700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUO02_RS05705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUO02_RS05720	COG2267	carboxylic ester hydrolase activity
HUO02_RS05730	COG1744	ABC transporter substrate-binding protein PnrA-like
HUO02_RS05745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO02_RS05750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO02_RS05755	COG5504	Zn-dependent protease
HUO02_RS05760	COG0444	Belongs to the ABC transporter superfamily
HUO02_RS05765	COG4608	Belongs to the ABC transporter superfamily
HUO02_RS05775	COG0601	transmembrane transport
HUO02_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO02_RS05790	COG0180	Tryptophanyl-tRNA synthetase
HUO02_RS05795	COG4166	transmembrane transport
HUO02_RS05800	COG0601	transmembrane transport
HUO02_RS05805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO02_RS05810	COG0444	Belongs to the ABC transporter superfamily
HUO02_RS05815	COG4608	Belongs to the ABC transporter superfamily
HUO02_RS05825	COG0456	acetyltransferase
HUO02_RS05830	COG1393	Belongs to the ArsC family
HUO02_RS05835	COG0861	Integral membrane protein TerC family
HUO02_RS05845	COG4862	establishment of competence for transformation
HUO02_RS05850	COG4469	Competence protein
HUO02_RS05855	COG1164	Oligoendopeptidase f
HUO02_RS05870	COG2346	COG2346, Truncated hemoglobins
HUO02_RS05875	COG0741	lytic transglycosylase activity
HUO02_RS05880	COG4116	CYTH
HUO02_RS05890	COG2357	RelA SpoT domain protein
HUO02_RS05895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUO02_RS05900	COG0564	pseudouridine synthase activity
HUO02_RS05910	COG0475	glutathione-regulated potassium exporter activity
HUO02_RS05910	COG0569	domain protein
HUO02_RS05915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HUO02_RS05920	COG0352	thiamine-phosphate diphosphorylase activity
HUO02_RS05925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO02_RS05930	COG2104	thiamine diphosphate biosynthetic process
HUO02_RS05940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUO02_RS05945	COG0351	phosphomethylpyrimidine kinase
HUO02_RS05950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUO02_RS06005	COG0210	DNA helicase
HUO02_RS06025	COG1131	(ABC) transporter
HUO02_RS06035	COG2153	protein acetylation
HUO02_RS06045	COG2382	esterase
HUO02_RS06050	COG0626	cystathionine gamma-synthase activity
HUO02_RS06055	COG0626	cystathionine gamma-synthase activity
HUO02_RS06070	COG5444	nuclease activity
HUO02_RS06105	COG5444	nuclease activity
HUO02_RS06135	COG2367	Beta-lactamase
HUO02_RS06140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HUO02_RS06145	COG0477	Major facilitator Superfamily
HUO02_RS06150	COG1846	Transcriptional regulator
HUO02_RS06160	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUO02_RS06165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUO02_RS06170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUO02_RS06175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS06175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS06180	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUO02_RS06210	COG1285	pathogenesis
HUO02_RS06225	COG2205	protein histidine kinase activity
HUO02_RS06235	COG3383	formate dehydrogenase (NAD+) activity
HUO02_RS06240	COG2427	Protein of unknown function (DUF1641)
HUO02_RS06245	COG2124	cytochrome p450
HUO02_RS06250	COG1819	glycosyl
HUO02_RS06260	COG1587	Uroporphyrinogen-III synthase
HUO02_RS06265	COG0390	transport system, permease component
HUO02_RS06270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO02_RS06275	COG0697	spore germination
HUO02_RS06280	COG4297	protein containing double-stranded beta helix domain
HUO02_RS06290	COG1252	NADH dehydrogenase
HUO02_RS06300	COG2211	Major facilitator Superfamily
HUO02_RS06305	COG1609	Transcriptional regulator
HUO02_RS06310	COG0246	Mannitol dehydrogenase
HUO02_RS06315	COG2721	sulfolactate sulfo-lyase activity
HUO02_RS06320	COG0730	response to heat
HUO02_RS06325	COG2318	DinB family
HUO02_RS06330	COG0457	Tetratricopeptide repeat
HUO02_RS06340	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS06340	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS06340	COG1388	LysM domain
HUO02_RS06350	COG4195	phage-related replication protein
HUO02_RS06355	COG2856	Zn peptidase
HUO02_RS06360	COG1396	sequence-specific DNA binding
HUO02_RS06375	COG1484	DNA-dependent DNA replication
HUO02_RS06395	COG1595	DNA-templated transcription, initiation
HUO02_RS06435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS06435	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS06450	COG0306	phosphate transporter
HUO02_RS06455	COG1392	Phosphate transport regulator
HUO02_RS06460	COG0531	amino acid
HUO02_RS06465	COG0346	lactoylglutathione lyase activity
HUO02_RS06470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUO02_RS06475	COG0463	Glycosyl transferase, family 2
HUO02_RS06485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO02_RS06490	COG0477	Major facilitator Superfamily
HUO02_RS06495	COG2362	D-Aminopeptidase
HUO02_RS06500	COG0601	transmembrane transport
HUO02_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO02_RS06510	COG0444	Belongs to the ABC transporter superfamily
HUO02_RS06515	COG4166	transmembrane transport
HUO02_RS06520	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUO02_RS06525	COG4948	Mandelate Racemase Muconate Lactonizing
HUO02_RS06530	COG0791	NLP P60 protein
HUO02_RS06535	COG4608	Belongs to the ABC transporter superfamily
HUO02_RS06540	COG2706	6-phosphogluconolactonase activity
HUO02_RS06545	COG1834	amidinotransferase
HUO02_RS06550	COG1607	acyl-coa hydrolase
HUO02_RS06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO02_RS06560	COG2076	Multidrug Resistance protein
HUO02_RS06565	COG2076	Multidrug Resistance protein
HUO02_RS06570	COG0788	formyltetrahydrofolate deformylase activity
HUO02_RS06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUO02_RS06585	COG1764	response to oxidative stress
HUO02_RS06590	COG1846	Transcriptional regulator
HUO02_RS06595	COG1764	response to oxidative stress
HUO02_RS06610	COG0463	Glycosyl transferase, family 2
HUO02_RS06610	COG0457	Tetratricopeptide repeat
HUO02_RS06620	COG2814	Major facilitator Superfamily
HUO02_RS06625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO02_RS06635	COG1404	Belongs to the peptidase S8 family
HUO02_RS06640	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS06645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUO02_RS06650	COG1122	ATPase activity
HUO02_RS06655	COG4721	ABC-type cobalt transport system, permease component
HUO02_RS06660	COG1388	LysM domain
HUO02_RS06660	COG3858	chitin binding
HUO02_RS06670	COG2239	Acts as a magnesium transporter
HUO02_RS06675	COG0789	Transcriptional regulator
HUO02_RS06690	COG1846	Transcriptional regulator
HUO02_RS06695	COG0726	polysaccharide deacetylase
HUO02_RS06700	COG3285	dna ligase
HUO02_RS06700	COG1793	dna ligase
HUO02_RS06705	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUO02_RS06710	COG0586	Pfam SNARE associated Golgi protein
HUO02_RS06715	COG0861	Integral membrane protein TerC family
HUO02_RS06720	COG1191	sigma factor activity
HUO02_RS06745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUO02_RS06750	COG2323	membrane
HUO02_RS06760	COG3594	Acyltransferase
HUO02_RS06765	COG5002	protein histidine kinase activity
HUO02_RS06770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUO02_RS06785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUO02_RS06790	COG0436	Aminotransferase
HUO02_RS06820	COG3852	Histidine kinase
HUO02_RS06825	COG1846	Transcriptional regulator
HUO02_RS06830	COG1360	Flagellar Motor Protein
HUO02_RS06835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUO02_RS06840	COG0542	response to heat
HUO02_RS06845	COG3949	Membrane
HUO02_RS06860	COG0720	synthase
HUO02_RS06865	COG0602	queuosine metabolic process
HUO02_RS06880	COG1733	regulation of RNA biosynthetic process
HUO02_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS06900	COG4873	Protein conserved in bacteria
HUO02_RS06910	COG3773	Cell wall hydrolase
HUO02_RS06915	COG2244	polysaccharide biosynthetic process
HUO02_RS06920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS06925	COG2217	Heavy metal translocating P-type atpase
HUO02_RS06930	COG0006	proline dipeptidase activity
HUO02_RS06935	COG1609	Transcriptional regulator
HUO02_RS06940	COG3711	transcriptional antiterminator
HUO02_RS06945	COG1263	PTS System
HUO02_RS06945	COG2190	(PTS) system
HUO02_RS06945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS06950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS06955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUO02_RS06965	COG1533	DNA photolyase activity
HUO02_RS06970	COG0840	transmembrane signaling receptor activity
HUO02_RS06975	COG2084	Dehydrogenase
HUO02_RS06985	COG2340	Cysteine-rich secretory protein family
HUO02_RS06990	COG0768	penicillin binding
HUO02_RS06995	COG4191	Histidine kinase
HUO02_RS07000	COG0436	Aminotransferase
HUO02_RS07010	COG0835	chemotaxis
HUO02_RS07010	COG0784	Response regulator, receiver
HUO02_RS07020	COG2814	Major facilitator Superfamily
HUO02_RS07025	COG1376	ErfK ybiS ycfS ynhG family protein
HUO02_RS07030	COG1408	metallophosphoesterase
HUO02_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS07045	COG2200	EAL domain
HUO02_RS07050	COG4703	Protein of unknown function (DUF1797)
HUO02_RS07055	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HUO02_RS07065	COG0517	IMP dehydrogenase activity
HUO02_RS07070	COG0583	DNA-binding transcription factor activity
HUO02_RS07075	COG0716	FMN binding
HUO02_RS07085	COG0716	FMN binding
HUO02_RS07105	COG0668	transmembrane transport
HUO02_RS07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS07130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUO02_RS07135	COG0303	'Molybdopterin
HUO02_RS07140	COG1763	Mo-molybdopterin cofactor biosynthetic process
HUO02_RS07145	COG0314	molybdopterin synthase activity
HUO02_RS07150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUO02_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO02_RS07165	COG1136	(ABC) transporter
HUO02_RS07170	COG0577	efflux transmembrane transporter activity
HUO02_RS07175	COG1349	DNA-binding transcription factor activity
HUO02_RS07180	COG1105	Belongs to the carbohydrate kinase PfkB family
HUO02_RS07185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO02_RS07185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS07185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO02_RS07190	COG0681	Belongs to the peptidase S26 family
HUO02_RS07200	COG0488	(ABC) transporter
HUO02_RS07205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUO02_RS07210	COG2309	aminopeptidase activity
HUO02_RS07220	COG1077	Cell shape determining protein MreB Mrl
HUO02_RS07225	COG2002	toxin-antitoxin pair type II binding
HUO02_RS07230	COG3852	Histidine kinase
HUO02_RS07235	COG2105	PFAM AIG2 family protein
HUO02_RS07235	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HUO02_RS07240	COG0569	domain protein
HUO02_RS07250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUO02_RS07260	COG0561	phosphatase activity
HUO02_RS07265	COG0242	peptide deformylase activity
HUO02_RS07275	COG0497	DNA recombination
HUO02_RS07285	COG3321	synthase
HUO02_RS07285	COG4221	oxidoreductase activity
HUO02_RS07285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS07290	COG4221	oxidoreductase activity
HUO02_RS07290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS07290	COG3321	synthase
HUO02_RS07290	COG0300	oxidoreductase activity
HUO02_RS07295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS07295	COG4221	oxidoreductase activity
HUO02_RS07295	COG3321	synthase
HUO02_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS07300	COG4221	oxidoreductase activity
HUO02_RS07300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS07300	COG0300	oxidoreductase activity
HUO02_RS07300	COG3321	synthase
HUO02_RS07305	COG4221	oxidoreductase activity
HUO02_RS07305	COG3321	synthase
HUO02_RS07305	COG0300	oxidoreductase activity
HUO02_RS07305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS07310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS07310	COG0300	oxidoreductase activity
HUO02_RS07310	COG3321	synthase
HUO02_RS07310	COG4221	oxidoreductase activity
HUO02_RS07315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS07315	COG4221	oxidoreductase activity
HUO02_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS07315	COG3321	synthase
HUO02_RS07320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO02_RS07325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUO02_RS07330	COG0022	dehydrogenase e1 component
HUO02_RS07335	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO02_RS07340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO02_RS07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS07360	COG1982	Orn Lys Arg decarboxylase major
HUO02_RS07380	COG0483	inositol monophosphate 1-phosphatase activity
HUO02_RS07425	COG1595	DNA-templated transcription, initiation
HUO02_RS07455	COG4896	Protein conserved in bacteria
HUO02_RS07465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUO02_RS07470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUO02_RS07475	COG2066	Belongs to the glutaminase family
HUO02_RS07485	COG0772	Belongs to the SEDS family
HUO02_RS07490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUO02_RS07505	COG2010	Cytochrome c
HUO02_RS07505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUO02_RS07510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUO02_RS07515	COG1845	cytochrome c oxidase, subunit III
HUO02_RS07520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUO02_RS07525	COG3336	cytochrome c oxidase
HUO02_RS07535	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HUO02_RS07540	COG2340	Cysteine-rich secretory protein family
HUO02_RS07555	COG3679	Belongs to the UPF0342 family
HUO02_RS07565	COG0742	ribosomal rna small subunit methyltransferase
HUO02_RS07575	COG3314	Sporulation integral membrane protein YlbJ
HUO02_RS07580	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUO02_RS07585	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUO02_RS07595	COG1399	metal-binding, possibly nucleic acid-binding protein
HUO02_RS07615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUO02_RS07635	COG4839	cell division protein FtsL
HUO02_RS07645	COG0768	penicillin binding
HUO02_RS07665	COG0772	Belongs to the SEDS family
HUO02_RS07680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUO02_RS07685	COG0849	cell division
HUO02_RS07690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUO02_RS07695	COG4412	M6 family metalloprotease domain protein
HUO02_RS07695	COG1404	Belongs to the peptidase S8 family
HUO02_RS07705	COG1191	sigma factor activity
HUO02_RS07710	COG1191	sigma factor activity
HUO02_RS07715	COG1119	ATPase activity
HUO02_RS07720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO02_RS07725	COG1873	PFAM PRC-barrel domain
HUO02_RS07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUO02_RS07745	COG0762	integral membrane protein
HUO02_RS07750	COG2302	S4 RNA-binding domain
HUO02_RS07755	COG3599	regulation of cell shape
HUO02_RS07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUO02_RS07765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUO02_RS07775	COG0564	pseudouridine synthase activity
HUO02_RS07785	COG2233	PERMEase
HUO02_RS07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUO02_RS07800	COG0505	Belongs to the CarA family
HUO02_RS07805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUO02_RS07820	COG0284	orotidine-5'-phosphate decarboxylase activity
HUO02_RS07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUO02_RS07835	COG0306	phosphate transporter
HUO02_RS07850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUO02_RS07855	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HUO02_RS07860	COG1648	precorrin-2 dehydrogenase activity
HUO02_RS07870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUO02_RS07875	COG1561	YicC-like family, N-terminal region
HUO02_RS07885	COG0194	GDP metabolic process
HUO02_RS07895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUO02_RS07900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUO02_RS07905	COG0242	peptide deformylase activity
HUO02_RS07915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUO02_RS07915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUO02_RS07925	COG0631	protein serine/threonine phosphatase activity
HUO02_RS07930	COG2815	serine threonine protein kinase
HUO02_RS07930	COG0515	serine threonine protein kinase
HUO02_RS07940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUO02_RS07945	COG1564	THIamine pyrophosphokinase
HUO02_RS07960	COG1302	Protein conserved in bacteria
HUO02_RS07965	COG1461	Dihydroxyacetone kinase
HUO02_RS07970	COG1760	l-serine dehydratase
HUO02_RS07975	COG1760	l-serine dehydratase
HUO02_RS07980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUO02_RS07995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUO02_RS08000	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS08015	COG1196	nuclear chromosome segregation
HUO02_RS08020	COG0552	protein localization to endoplasmic reticulum
HUO02_RS08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUO02_RS08045	COG1837	Belongs to the UPF0109 family
HUO02_RS08070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUO02_RS08085	COG2257	FlhB HrpN YscU SpaS Family
HUO02_RS08095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUO02_RS08100	COG0758	DNA mediated transformation
HUO02_RS08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO02_RS08115	COG4974	Belongs to the 'phage' integrase family
HUO02_RS08135	COG1815	bacterial-type flagellum-dependent cell motility
HUO02_RS08140	COG1558	bacterial-type flagellum-dependent cell motility
HUO02_RS08145	COG1677	Flagellar hook-basal body complex protein FliE
HUO02_RS08150	COG1766	The M ring may be actively involved in energy transduction
HUO02_RS08155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUO02_RS08160	COG1317	bacterial-type flagellum organization
HUO02_RS08165	COG1157	protein secretion by the type III secretion system
HUO02_RS08170	COG2882	bacterial-type flagellum organization
HUO02_RS08175	COG3334	PFAM MgtE intracellular
HUO02_RS08180	COG3144	bacterial-type flagellum assembly
HUO02_RS08185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUO02_RS08190	COG4786	Flagellar basal body rod
HUO02_RS08195	COG1582	Flagellar protein (FlbD)
HUO02_RS08200	COG1580	Controls the rotational direction of flagella during chemotaxis
HUO02_RS08205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUO02_RS08210	COG1776	CheC inhibitor of MCP methylation
HUO02_RS08210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUO02_RS08215	COG2201	protein-glutamate methylesterase activity
HUO02_RS08220	COG3190	flagellar
HUO02_RS08225	COG1338	Plays a role in the flagellum-specific transport system
HUO02_RS08230	COG1987	bacterial-type flagellum assembly
HUO02_RS08235	COG1684	flagellar biosynthetic protein fliR
HUO02_RS08240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUO02_RS08245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUO02_RS08250	COG1419	protein localization to endoplasmic reticulum
HUO02_RS08255	COG0455	bacterial-type flagellum organization
HUO02_RS08260	COG2201	protein-glutamate methylesterase activity
HUO02_RS08265	COG2198	Histidine kinase
HUO02_RS08265	COG0643	Histidine kinase
HUO02_RS08270	COG0835	chemotaxis
HUO02_RS08275	COG1776	CheC inhibitor of MCP methylation
HUO02_RS08285	COG1191	sigma factor activity
HUO02_RS08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUO02_RS08320	COG4589	Belongs to the CDS family
HUO02_RS08330	COG0750	zinc metalloprotease
HUO02_RS08340	COG2176	DNA-directed DNA polymerase activity
HUO02_RS08350	COG0195	Participates in both transcription termination and antitermination
HUO02_RS08355	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HUO02_RS08360	COG1358	cellular component organization or biogenesis
HUO02_RS08370	COG1550	Protein conserved in bacteria
HUO02_RS08385	COG0196	riboflavin kinase activity
HUO02_RS08400	COG0726	polysaccharide deacetylase
HUO02_RS08405	COG0612	Peptidase, M16
HUO02_RS08410	COG1873	PFAM PRC-barrel domain
HUO02_RS08415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUO02_RS08420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUO02_RS08425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUO02_RS08430	COG0527	aspartate kinase activity
HUO02_RS08440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUO02_RS08445	COG0740	serine-type endopeptidase activity
HUO02_RS08455	COG1674	ftsk spoiiie
HUO02_RS08455	COG4980	gas vesicle protein
HUO02_RS08460	COG2188	Transcriptional regulator
HUO02_RS08465	COG2814	Major facilitator Superfamily
HUO02_RS08470	COG1846	Transcriptional regulator
HUO02_RS08475	COG1033	growth of symbiont in host cell
HUO02_RS08475	COG2409	Drug exporters of the RND superfamily
HUO02_RS08480	COG0612	Peptidase, M16
HUO02_RS08485	COG0612	Peptidase, M16
HUO02_RS08490	COG0300	oxidoreductase activity
HUO02_RS08505	COG1426	Protein conserved in bacteria
HUO02_RS08510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUO02_RS08525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUO02_RS08535	COG1692	metallophosphoesterase
HUO02_RS08540	COG2359	stage V sporulation protein S
HUO02_RS08560	COG4550	Control of competence regulator ComK, YlbF/YmcA
HUO02_RS08605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS08610	COG3425	synthase
HUO02_RS08615	COG1024	Enoyl-CoA hydratase
HUO02_RS08620	COG1024	Enoyl-CoA hydratase
HUO02_RS08625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS08625	COG3321	synthase
HUO02_RS08625	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS08625	COG0300	oxidoreductase activity
HUO02_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS08630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS08630	COG3321	synthase
HUO02_RS08630	COG0300	oxidoreductase activity
HUO02_RS08630	COG4221	oxidoreductase activity
HUO02_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS08635	COG3321	synthase
HUO02_RS08635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS08635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS08635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS08635	COG3321	synthase
HUO02_RS08635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS08640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS08640	COG4221	oxidoreductase activity
HUO02_RS08640	COG3321	synthase
HUO02_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS08645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS08645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUO02_RS08645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HUO02_RS08645	COG3321	synthase
HUO02_RS08650	COG2124	cytochrome p450
HUO02_RS08655	COG3209	COG3209 Rhs family protein
HUO02_RS08660	COG3619	membrane
HUO02_RS08670	COG1404	Belongs to the peptidase S8 family
HUO02_RS08680	COG4195	phage-related replication protein
HUO02_RS08685	COG1764	response to oxidative stress
HUO02_RS08695	COG2076	Multidrug Resistance protein
HUO02_RS08735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUO02_RS08740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUO02_RS08745	COG4112	unkown
HUO02_RS08750	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS08755	COG0464	growth
HUO02_RS08760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUO02_RS08765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HUO02_RS08770	COG0789	Transcriptional regulator
HUO02_RS08775	COG0174	glutamine synthetase
HUO02_RS08800	COG2211	Major facilitator Superfamily
HUO02_RS08805	COG3507	Belongs to the glycosyl hydrolase 43 family
HUO02_RS08820	COG1070	Carbohydrate kinase
HUO02_RS08825	COG3848	Pyruvate phosphate dikinase
HUO02_RS08825	COG0574	Belongs to the PEP-utilizing enzyme family
HUO02_RS08855	COG1064	alcohol dehydrogenase
HUO02_RS08870	COG0456	acetyltransferase
HUO02_RS08905	COG3397	chitin binding
HUO02_RS08925	COG5434	Belongs to the glycosyl hydrolase 28 family
HUO02_RS08930	COG0756	dUTP diphosphatase activity
HUO02_RS08940	COG4195	phage-related replication protein
HUO02_RS08975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUO02_RS08985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUO02_RS09005	COG0785	Cytochrome C biogenesis protein
HUO02_RS09010	COG2201	protein-glutamate methylesterase activity
HUO02_RS09015	COG4846	Membrane protein involved in cytochrome C biogenesis
HUO02_RS09025	COG0071	Belongs to the small heat shock protein (HSP20) family
HUO02_RS09040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUO02_RS09045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS09065	COG0824	Thioesterase
HUO02_RS09075	COG4841	protein insertion into membrane
HUO02_RS09085	COG1832	CoA-binding protein
HUO02_RS09090	COG0187	DNA topoisomerase II activity
HUO02_RS09095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUO02_RS09105	COG1115	amino acid carrier protein
HUO02_RS09115	COG1063	alcohol dehydrogenase
HUO02_RS09120	COG0800	Aldolase
HUO02_RS09125	COG1312	Catalyzes the dehydration of D-mannonate
HUO02_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS09135	COG1609	Transcriptional regulator
HUO02_RS09140	COG2271	Major facilitator Superfamily
HUO02_RS09185	COG2205	protein histidine kinase activity
HUO02_RS09190	COG0745	RESPONSE REGULATOR receiver
HUO02_RS09200	COG3507	Belongs to the glycosyl hydrolase 43 family
HUO02_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS09230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUO02_RS09235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUO02_RS09240	COG2610	gluconate transmembrane transporter activity
HUO02_RS09245	COG2124	cytochrome p450
HUO02_RS09265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUO02_RS09275	COG2246	polysaccharide biosynthetic process
HUO02_RS09280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUO02_RS09285	COG0586	Pfam SNARE associated Golgi protein
HUO02_RS09290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUO02_RS09295	COG1024	Enoyl-CoA hydratase
HUO02_RS09300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUO02_RS09305	COG0511	ligase activity, forming carbon-carbon bonds
HUO02_RS09310	COG0439	Biotin carboxylase
HUO02_RS09315	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS09320	COG1960	acyl-CoA dehydrogenase activity
HUO02_RS09325	COG1649	PFAM Uncharacterised BCR, COG1649
HUO02_RS09335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS09335	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HUO02_RS09340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS09360	COG2027	D-alanyl-D-alanine carboxypeptidase
HUO02_RS09365	COG2017	converts alpha-aldose to the beta-anomer
HUO02_RS09370	COG0534	Mate efflux family protein
HUO02_RS09385	COG0582	viral genome integration into host DNA
HUO02_RS09390	COG0166	Belongs to the GPI family
HUO02_RS09395	COG0405	Gamma-glutamyltransferase
HUO02_RS09400	COG2814	Major facilitator Superfamily
HUO02_RS09405	COG0640	Transcriptional regulator
HUO02_RS09410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUO02_RS09420	COG0604	alcohol dehydrogenase
HUO02_RS09430	COG0493	'glutamate synthase
HUO02_RS09435	COG0069	glutamate synthase activity
HUO02_RS09435	COG0070	glutamate synthase
HUO02_RS09435	COG0067	glutamate synthase
HUO02_RS09440	COG0583	DNA-binding transcription factor activity
HUO02_RS09445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUO02_RS09480	COG0300	oxidoreductase activity
HUO02_RS09485	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HUO02_RS09495	COG2814	Major facilitator Superfamily
HUO02_RS09500	COG1070	Carbohydrate kinase
HUO02_RS09505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUO02_RS09510	COG0243	molybdopterin cofactor binding
HUO02_RS09540	COG5444	nuclease activity
HUO02_RS09545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO02_RS09550	COG2207	Transcriptional regulator
HUO02_RS09550	COG0662	Cupin 2, conserved barrel domain protein
HUO02_RS09555	COG1309	transcriptional regulator
HUO02_RS09560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS09570	COG0640	Transcriptional regulator
HUO02_RS09575	COG0741	lytic transglycosylase activity
HUO02_RS09580	COG2322	membrane
HUO02_RS09595	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUO02_RS09605	COG1388	LysM domain
HUO02_RS09605	COG3584	3D domain protein
HUO02_RS09610	COG0514	ATP-dependent DNA helicase (RecQ)
HUO02_RS09620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUO02_RS09625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUO02_RS09640	COG0071	Belongs to the small heat shock protein (HSP20) family
HUO02_RS09670	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS09675	COG1657	PFAM Prenyltransferase squalene oxidase
HUO02_RS09680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUO02_RS09685	COG0733	neurotransmitter:sodium symporter activity
HUO02_RS09690	COG0385	Bile acid
HUO02_RS09695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS09700	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO02_RS09710	COG4548	von Willebrand factor, type A
HUO02_RS09715	COG0714	Associated with various cellular activities
HUO02_RS09720	COG2032	superoxide dismutase activity
HUO02_RS09725	COG1388	LysM domain
HUO02_RS09725	COG0791	NLP P60 protein
HUO02_RS09730	COG1819	glycosyl
HUO02_RS09735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUO02_RS09740	COG0534	Mate efflux family protein
HUO02_RS09745	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS09750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUO02_RS09755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUO02_RS09765	COG2962	Rard protein
HUO02_RS09780	COG1942	4-Oxalocrotonate Tautomerase
HUO02_RS09790	COG1733	regulation of RNA biosynthetic process
HUO02_RS09795	COG0778	Nitroreductase
HUO02_RS09800	COG0400	carboxylic ester hydrolase activity
HUO02_RS09805	COG0346	lactoylglutathione lyase activity
HUO02_RS09815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO02_RS09825	COG2723	6-phospho-beta-galactosidase activity
HUO02_RS09830	COG2188	Transcriptional regulator
HUO02_RS09835	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS09835	COG0793	Belongs to the peptidase S41A family
HUO02_RS09840	COG2226	methyltransferase
HUO02_RS09850	COG1876	peptidase activity
HUO02_RS09870	COG0671	phosphoesterase, PA-phosphatase related
HUO02_RS09905	COG1509	lysine 2,3-aminomutase activity
HUO02_RS09910	COG0456	acetyltransferase
HUO02_RS09915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO02_RS09920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUO02_RS09925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUO02_RS09930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUO02_RS09945	COG0456	acetyltransferase
HUO02_RS09950	COG0463	Glycosyl transferase, family 2
HUO02_RS09965	COG4641	Protein conserved in bacteria
HUO02_RS09975	COG1086	Polysaccharide biosynthesis protein
HUO02_RS09995	COG1388	LysM domain
HUO02_RS10000	COG0457	Tetratricopeptide repeat
HUO02_RS10015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO02_RS10015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS10030	COG4585	Histidine kinase
HUO02_RS10035	COG0730	response to heat
HUO02_RS10060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUO02_RS10080	COG1846	Transcriptional regulator
HUO02_RS10085	COG4698	Protein conserved in bacteria
HUO02_RS10090	COG2755	lipolytic protein G-D-S-L family
HUO02_RS10095	COG1999	signal sequence binding
HUO02_RS10105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUO02_RS10110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HUO02_RS10115	COG1272	protein, Hemolysin III
HUO02_RS10120	COG0204	Acyl-transferase
HUO02_RS10125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUO02_RS10140	COG2521	methyltransferase
HUO02_RS10140	COG2136	Putative SAM-dependent methyltransferase
HUO02_RS10155	COG1413	lyase activity
HUO02_RS10160	COG1418	mRNA catabolic process
HUO02_RS10165	COG0386	Belongs to the glutathione peroxidase family
HUO02_RS10175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUO02_RS10185	COG1278	Cold shock
HUO02_RS10205	COG0328	RNA-DNA hybrid ribonuclease activity
HUO02_RS10210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUO02_RS10215	COG0328	RNA-DNA hybrid ribonuclease activity
HUO02_RS10225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO02_RS10240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUO02_RS10250	COG1755	Isoprenylcysteine carboxyl methyltransferase
HUO02_RS10255	COG3424	synthase
HUO02_RS10275	COG2323	membrane
HUO02_RS10280	COG1335	isochorismatase
HUO02_RS10290	COG2233	PERMEase
HUO02_RS10300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUO02_RS10305	COG1199	ATP-dependent helicase activity
HUO02_RS10325	COG0116	Belongs to the methyltransferase superfamily
HUO02_RS10355	COG3359	exonuclease
HUO02_RS10360	COG1111	helicase
HUO02_RS10360	COG1205	dead DEAH box helicase
HUO02_RS10365	COG2190	(PTS) system
HUO02_RS10370	COG0071	Belongs to the small heat shock protein (HSP20) family
HUO02_RS10410	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUO02_RS10410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO02_RS10420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUO02_RS10425	COG3935	DnaD domain protein
HUO02_RS10435	COG0436	Aminotransferase
HUO02_RS10440	COG5353	protein conserved in bacteria
HUO02_RS10450	COG1199	ATP-dependent helicase activity
HUO02_RS10450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUO02_RS10480	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS10485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUO02_RS10500	COG1694	Mazg nucleotide pyrophosphohydrolase
HUO02_RS10505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS10510	COG2140	Oxalate decarboxylase
HUO02_RS10520	COG4347	Protein of unknown function (DUF1405)
HUO02_RS10525	COG2010	Cytochrome c
HUO02_RS10525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUO02_RS10530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUO02_RS10535	COG0723	plastoquinol--plastocyanin reductase activity
HUO02_RS10550	COG0457	Tetratricopeptide repeat
HUO02_RS10560	COG0287	Prephenate dehydrogenase
HUO02_RS10595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUO02_RS10600	COG4401	Chorismate mutase type I
HUO02_RS10615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUO02_RS10620	COG0105	UTP biosynthetic process
HUO02_RS10625	COG0142	geranyltranstransferase activity
HUO02_RS10635	COG0142	geranyltranstransferase activity
HUO02_RS10650	COG0776	regulation of translation
HUO02_RS10655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUO02_RS10695	COG0539	negative regulation of cytoplasmic translation
HUO02_RS10715	COG2959	enzyme of heme biosynthesis
HUO02_RS10720	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS10720	COG3773	Cell wall hydrolase
HUO02_RS10725	COG2339	peptidase activity
HUO02_RS10730	COG0492	ferredoxin-NADP+ reductase activity
HUO02_RS10735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUO02_RS10740	COG4862	establishment of competence for transformation
HUO02_RS10745	COG1408	metallophosphoesterase
HUO02_RS10755	COG1388	LysM domain
HUO02_RS10760	COG1266	CAAX protease self-immunity
HUO02_RS10765	COG0514	ATP-dependent DNA helicase (RecQ)
HUO02_RS10770	COG4955	Helix-turn-helix domain
HUO02_RS10775	COG1141	Ferredoxin
HUO02_RS10780	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HUO02_RS10785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUO02_RS10795	COG1595	DNA-templated transcription, initiation
HUO02_RS10800	COG5002	protein histidine kinase activity
HUO02_RS10805	COG0745	RESPONSE REGULATOR receiver
HUO02_RS10810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUO02_RS10815	COG1333	cytochrome c biogenesis protein
HUO02_RS10820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS10825	COG1187	pseudouridine synthase activity
HUO02_RS10830	COG0700	Nucleoside recognition
HUO02_RS10835	COG2715	membrane protein required for spore maturation
HUO02_RS10840	COG1686	Belongs to the peptidase S11 family
HUO02_RS10865	COG1547	Domain of unknown function (DUF309)
HUO02_RS10870	COG0456	acetyltransferase
HUO02_RS10885	COG0307	riboflavin synthase, alpha
HUO02_RS10890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUO02_RS10890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUO02_RS10900	COG0681	Belongs to the peptidase S26 family
HUO02_RS10910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUO02_RS10915	COG4086	secreted protein
HUO02_RS10920	COG0019	diaminopimelate decarboxylase activity
HUO02_RS10925	COG0697	spore germination
HUO02_RS10940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO02_RS10960	COG1191	sigma factor activity
HUO02_RS10970	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS10975	COG1686	Belongs to the peptidase S11 family
HUO02_RS10980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUO02_RS10985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HUO02_RS10990	COG4974	Belongs to the 'phage' integrase family
HUO02_RS11000	COG0735	belongs to the Fur family
HUO02_RS11005	COG1300	Membrane
HUO02_RS11020	COG0281	malic enzyme
HUO02_RS11025	COG1757	Na H antiporter
HUO02_RS11030	COG1027	Aspartate ammonia-lyase
HUO02_RS11035	COG0252	asparaginase activity
HUO02_RS11040	COG1396	sequence-specific DNA binding
HUO02_RS11045	COG1379	DNA repair
HUO02_RS11050	COG0494	nUDIX hydrolase
HUO02_RS11060	COG0667	Aldo Keto reductase
HUO02_RS11070	COG1073	alpha beta
HUO02_RS11080	COG4918	Iron-sulphur cluster biosynthesis
HUO02_RS11085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUO02_RS11085	COG0456	acetyltransferase
HUO02_RS11090	COG2329	Antibiotic biosynthesis monooxygenase
HUO02_RS11095	COG0456	acetyltransferase
HUO02_RS11100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUO02_RS11115	COG0628	permease
HUO02_RS11125	COG0346	lactoylglutathione lyase activity
HUO02_RS11135	COG3048	D-serine ammonia-lyase activity
HUO02_RS11140	COG0300	oxidoreductase activity
HUO02_RS11145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS11150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUO02_RS11155	COG1024	Enoyl-CoA hydratase
HUO02_RS11160	COG3425	synthase
HUO02_RS11165	COG2124	cytochrome p450
HUO02_RS11170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS11170	COG3321	synthase
HUO02_RS11170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS11175	COG3321	synthase
HUO02_RS11175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS11180	COG3321	synthase
HUO02_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11180	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS11180	COG0300	oxidoreductase activity
HUO02_RS11185	COG3321	synthase
HUO02_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11185	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS11185	COG0300	oxidoreductase activity
HUO02_RS11190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS11190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS11190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11190	COG3321	synthase
HUO02_RS11195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11195	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS11195	COG0300	oxidoreductase activity
HUO02_RS11195	COG3321	synthase
HUO02_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO02_RS11200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS11200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS11200	COG3321	synthase
HUO02_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS11210	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS11225	COG2070	2-Nitropropane dioxygenase
HUO02_RS11225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUO02_RS11230	COG0250	Participates in transcription elongation, termination and antitermination
HUO02_RS11250	COG0596	Alpha beta hydrolase
HUO02_RS11265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUO02_RS11270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUO02_RS11285	COG0706	membrane insertase activity
HUO02_RS11290	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO02_RS11295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUO02_RS11300	COG0346	lactoylglutathione lyase activity
HUO02_RS11310	COG1376	ErfK ybiS ycfS ynhG family protein
HUO02_RS11315	COG4129	membrane
HUO02_RS11320	COG1126	abc transporter atp-binding protein
HUO02_RS11325	COG0765	amino acid transport
HUO02_RS11330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO02_RS11340	COG1597	lipid kinase activity
HUO02_RS11345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO02_RS11350	COG0022	dehydrogenase e1 component
HUO02_RS11355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUO02_RS11360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO02_RS11365	COG3426	butyrate kinase activity
HUO02_RS11370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUO02_RS11375	COG0280	phosphate acetyltransferase
HUO02_RS11380	COG3829	transcription factor binding
HUO02_RS11380	COG3290	protein histidine kinase activity
HUO02_RS11390	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUO02_RS11395	COG2079	MmgE PrpD family protein
HUO02_RS11400	COG0372	Belongs to the citrate synthase family
HUO02_RS11405	COG1960	acyl-CoA dehydrogenase activity
HUO02_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUO02_RS11415	COG0183	Belongs to the thiolase family
HUO02_RS11420	COG0584	glycerophosphoryl diester phosphodiesterase
HUO02_RS11425	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS11450	COG1902	pentaerythritol trinitrate reductase activity
HUO02_RS11465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUO02_RS11470	COG0745	RESPONSE REGULATOR receiver
HUO02_RS11475	COG0750	zinc metalloprotease
HUO02_RS11480	COG0497	DNA recombination
HUO02_RS11490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUO02_RS11500	COG0142	geranyltranstransferase activity
HUO02_RS11510	COG1570	exodeoxyribonuclease VII activity
HUO02_RS11525	COG1302	Protein conserved in bacteria
HUO02_RS11530	COG0439	Biotin carboxylase
HUO02_RS11535	COG0511	ligase activity, forming carbon-carbon bonds
HUO02_RS11575	COG3854	ATPases associated with a variety of cellular activities
HUO02_RS11590	COG0006	proline dipeptidase activity
HUO02_RS11600	COG3872	metal-dependent enzyme
HUO02_RS11610	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUO02_RS11625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO02_RS11645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUO02_RS11660	COG1396	sequence-specific DNA binding
HUO02_RS11670	COG0681	Belongs to the peptidase S26 family
HUO02_RS11695	COG4940	Competence protein ComGF
HUO02_RS11705	COG4970	Tfp pilus assembly protein FimT
HUO02_RS11710	COG4537	Required for transformation and DNA binding
HUO02_RS11715	COG1459	type II secretion system
HUO02_RS11720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO02_RS11725	COG0598	Magnesium transport protein CorA
HUO02_RS11730	COG1253	flavin adenine dinucleotide binding
HUO02_RS11735	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS11745	COG1393	Belongs to the ArsC family
HUO02_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS11765	COG0011	TIGRFAM Protein of
HUO02_RS11775	COG2866	Carboxypeptidase
HUO02_RS11780	COG1940	carbohydrate kinase activity
HUO02_RS11785	COG4483	Protein conserved in bacteria
HUO02_RS11790	COG1757	Na H antiporter
HUO02_RS11800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUO02_RS11815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUO02_RS11820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO02_RS11825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO02_RS11830	COG0581	inorganic phosphate transmembrane transporter activity
HUO02_RS11835	COG0573	inorganic phosphate transmembrane transporter activity
HUO02_RS11840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUO02_RS11855	COG0477	Major facilitator Superfamily
HUO02_RS11860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUO02_RS11865	COG2839	Protein conserved in bacteria
HUO02_RS11870	COG5521	maltodextrose utilization protein MalA
HUO02_RS11875	COG1388	LysM domain
HUO02_RS11885	COG4709	membrane
HUO02_RS11890	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HUO02_RS11895	COG0735	belongs to the Fur family
HUO02_RS11900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS11915	COG0513	Belongs to the DEAD box helicase family
HUO02_RS11930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUO02_RS11935	COG2384	SAM-dependent methyltransferase
HUO02_RS11940	COG2010	Cytochrome c
HUO02_RS11945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUO02_RS11950	COG0358	DNA primase activity
HUO02_RS11965	COG0517	IMP dehydrogenase activity
HUO02_RS11970	COG0751	glycine-tRNA ligase activity
HUO02_RS11990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUO02_RS11995	COG0295	cytidine deaminase activity
HUO02_RS12000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUO02_RS12010	COG1480	7TM receptor with intracellular HD hydrolase
HUO02_RS12015	COG1702	phosphate starvation-inducible protein PhoH
HUO02_RS12020	COG0561	phosphatase activity
HUO02_RS12035	COG4864	UPF0365 protein
HUO02_RS12040	COG1030	water channel activity
HUO02_RS12045	COG1610	YqeY-like protein
HUO02_RS12055	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUO02_RS12060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUO02_RS12065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUO02_RS12095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUO02_RS12110	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS12125	COG1466	dna polymerase III delta subunit
HUO02_RS12140	COG2333	competence protein COMEC
HUO02_RS12140	COG0658	competence protein
HUO02_RS12145	COG2131	deaminase
HUO02_RS12150	COG1596	polysaccharide export
HUO02_RS12150	COG1555	photosystem II stabilization
HUO02_RS12155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUO02_RS12160	COG2226	methyltransferase
HUO02_RS12165	COG0799	negative regulation of ribosome biogenesis
HUO02_RS12170	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUO02_RS12180	COG1534	Rna-binding protein
HUO02_RS12185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUO02_RS12190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUO02_RS12195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUO02_RS12205	COG2755	lipolytic protein G-D-S-L family
HUO02_RS12215	COG0398	Pfam SNARE associated Golgi protein
HUO02_RS12250	COG0642	Histidine kinase
HUO02_RS12250	COG5002	protein histidine kinase activity
HUO02_RS12255	COG0745	RESPONSE REGULATOR receiver
HUO02_RS12260	COG2311	Membrane
HUO02_RS12265	COG0454	-acetyltransferase
HUO02_RS12270	COG0563	adenylate kinase activity
HUO02_RS12285	COG2318	DinB family
HUO02_RS12295	COG0561	phosphatase activity
HUO02_RS12300	COG0561	phosphatase activity
HUO02_RS12310	COG1482	cell wall glycoprotein biosynthetic process
HUO02_RS12315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS12315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO02_RS12315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO02_RS12320	COG3711	transcriptional antiterminator
HUO02_RS12320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS12330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUO02_RS12335	COG0583	DNA-binding transcription factor activity
HUO02_RS12340	COG2814	Major facilitator Superfamily
HUO02_RS12345	COG2124	cytochrome p450
HUO02_RS12345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUO02_RS12350	COG1309	transcriptional regulator
HUO02_RS12355	COG2226	methyltransferase
HUO02_RS12370	COG2116	formate transmembrane transporter activity
HUO02_RS12375	COG5609	conserved protein (DUF2294)
HUO02_RS12380	COG3383	formate dehydrogenase (NAD+) activity
HUO02_RS12385	COG2427	Protein of unknown function (DUF1641)
HUO02_RS12395	COG0626	cystathionine gamma-synthase activity
HUO02_RS12400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO02_RS12425	COG0768	penicillin binding
HUO02_RS12450	COG4122	O-methyltransferase activity
HUO02_RS12455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUO02_RS12480	COG0628	permease
HUO02_RS12485	COG1126	abc transporter atp-binding protein
HUO02_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO02_RS12495	COG0765	amino acid transport
HUO02_RS12500	COG0765	amino acid transport
HUO02_RS12515	COG3881	PFAM PRC-barrel domain
HUO02_RS12520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUO02_RS12525	COG0457	Tetratricopeptide repeat
HUO02_RS12535	COG1104	cysteine desulfurase activity
HUO02_RS12540	COG1959	2 iron, 2 sulfur cluster binding
HUO02_RS12545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUO02_RS12550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUO02_RS12575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS12575	COG3103	Sh3 type 3 domain protein
HUO02_RS12575	COG4991	sh3 domain protein
HUO02_RS12585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUO02_RS12595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUO02_RS12595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUO02_RS12600	COG5416	Lipopolysaccharide assembly protein A domain
HUO02_RS12605	COG0490	domain, Protein
HUO02_RS12610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO02_RS12610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO02_RS12620	COG2244	polysaccharide biosynthetic process
HUO02_RS12625	COG2323	membrane
HUO02_RS12635	COG1862	Preprotein translocase
HUO02_RS12680	COG1388	LysM domain
HUO02_RS12690	COG0157	Belongs to the NadC ModD family
HUO02_RS12695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUO02_RS12700	COG1104	cysteine desulfurase activity
HUO02_RS12705	COG1827	regulation of RNA biosynthetic process
HUO02_RS12710	COG0077	Prephenate dehydratase
HUO02_RS12725	COG3290	protein histidine kinase activity
HUO02_RS12735	COG2868	ribosomal protein
HUO02_RS12745	COG1994	Peptidase M50
HUO02_RS12750	COG0739	heme binding
HUO02_RS12755	COG2894	cell division
HUO02_RS12765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HUO02_RS12775	COG1077	Cell shape determining protein MreB Mrl
HUO02_RS12795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUO02_RS12800	COG0285	dihydrofolate synthase activity
HUO02_RS12805	COG0525	valine-tRNA ligase activity
HUO02_RS12815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUO02_RS12820	COG1388	LysM domain
HUO02_RS12830	COG0113	porphobilinogen synthase activity
HUO02_RS12835	COG1587	Uroporphyrinogen-III synthase
HUO02_RS12845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUO02_RS12865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUO02_RS12870	COG1067	ATP-dependent peptidase activity
HUO02_RS12870	COG0470	DNA polymerase III
HUO02_RS12885	COG0457	Tetratricopeptide repeat
HUO02_RS12885	COG1477	protein flavinylation
HUO02_RS12900	COG0473	3-isopropylmalate dehydrogenase activity
HUO02_RS12915	COG0440	acetolactate synthase activity
HUO02_RS12920	COG0028	Belongs to the TPP enzyme family
HUO02_RS12945	COG0622	Phosphoesterase
HUO02_RS12950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUO02_RS12960	COG5401	PFAM Sporulation and spore germination
HUO02_RS12970	COG1846	Transcriptional regulator
HUO02_RS12975	COG2197	response regulator
HUO02_RS12980	COG0824	Thioesterase
HUO02_RS12985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUO02_RS12990	COG1053	succinate dehydrogenase
HUO02_RS12995	COG2009	succinate dehydrogenase
HUO02_RS13000	COG1719	4-vinyl reductase, 4VR
HUO02_RS13005	COG0527	aspartate kinase activity
HUO02_RS13015	COG3118	belongs to the thioredoxin family
HUO02_RS13020	COG3534	alpha-L-arabinofuranosidase
HUO02_RS13025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUO02_RS13030	COG2086	electron transfer activity
HUO02_RS13035	COG1024	Enoyl-CoA hydratase
HUO02_RS13040	COG1309	transcriptional regulator
HUO02_RS13045	COG0318	PFAM AMP-dependent synthetase and ligase
HUO02_RS13055	COG3766	membrane
HUO02_RS13065	COG1796	DNA polymerase
HUO02_RS13065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUO02_RS13070	COG1286	toxin biosynthetic process
HUO02_RS13085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO02_RS13085	COG0072	phenylalanine-tRNA ligase activity
HUO02_RS13090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUO02_RS13095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO02_RS13105	COG3835	regulator
HUO02_RS13110	COG0277	FAD linked oxidase domain protein
HUO02_RS13115	COG0247	lactate metabolic process
HUO02_RS13120	COG1966	Carbon starvation protein
HUO02_RS13125	COG3534	alpha-L-arabinofuranosidase
HUO02_RS13130	COG0395	ABC-type sugar transport system, permease component
HUO02_RS13135	COG1175	transmembrane transport
HUO02_RS13140	COG1653	transport
HUO02_RS13150	COG0647	UMP catabolic process
HUO02_RS13155	COG0235	Class ii aldolase
HUO02_RS13160	COG1069	ribulokinase activity
HUO02_RS13165	COG2160	L-arabinose isomerase activity
HUO02_RS13170	COG3507	Belongs to the glycosyl hydrolase 43 family
HUO02_RS13175	COG1363	Peptidase, m42
HUO02_RS13185	COG3326	Membrane
HUO02_RS13200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUO02_RS13205	COG1346	cytolysis
HUO02_RS13210	COG1380	Effector of murein hydrolase LrgA
HUO02_RS13215	COG3279	Response regulator of the LytR AlgR family
HUO02_RS13220	COG3275	phosphorelay sensor kinase activity
HUO02_RS13225	COG1011	Hydrolase
HUO02_RS13240	COG0398	Pfam SNARE associated Golgi protein
HUO02_RS13245	COG1484	DNA-dependent DNA replication
HUO02_RS13250	COG3611	Membrane attachment protein
HUO02_RS13265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUO02_RS13270	COG1733	regulation of RNA biosynthetic process
HUO02_RS13275	COG2814	Major facilitator Superfamily
HUO02_RS13280	COG0656	L-ascorbic acid biosynthetic process
HUO02_RS13285	COG0237	dephospho-CoA kinase activity
HUO02_RS13290	COG1971	Probably functions as a manganese efflux pump
HUO02_RS13295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUO02_RS13300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO02_RS13300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO02_RS13305	COG5002	protein histidine kinase activity
HUO02_RS13310	COG0745	RESPONSE REGULATOR receiver
HUO02_RS13320	COG0538	isocitrate dehydrogenase activity
HUO02_RS13325	COG0372	Belongs to the citrate synthase family
HUO02_RS13340	COG0628	permease
HUO02_RS13345	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUO02_RS13350	COG0469	pyruvate kinase activity
HUO02_RS13370	COG0281	malic enzyme
HUO02_RS13375	COG0587	DNA-directed DNA polymerase activity
HUO02_RS13395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUO02_RS13405	COG4109	DRTGG domain
HUO02_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS13430	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUO02_RS13440	COG0827	DNA restriction-modification system
HUO02_RS13445	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUO02_RS13450	COG3874	Sporulation protein YtfJ
HUO02_RS13460	COG1714	RDD family
HUO02_RS13465	COG0616	signal peptide processing
HUO02_RS13470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUO02_RS13475	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUO02_RS13480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUO02_RS13495	COG1104	cysteine desulfurase activity
HUO02_RS13500	COG1114	Component of the transport system for branched-chain amino acids
HUO02_RS13510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUO02_RS13515	COG1309	transcriptional regulator
HUO02_RS13520	COG1956	GAF domain-containing protein
HUO02_RS13525	COG2203	Gaf domain
HUO02_RS13525	COG2199	diguanylate cyclase activity
HUO02_RS13535	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS13540	COG4282	regulation of fungal-type cell wall biogenesis
HUO02_RS13560	COG1595	DNA-templated transcription, initiation
HUO02_RS13580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUO02_RS13580	COG1017	nitric oxide dioxygenase activity
HUO02_RS13595	COG0693	protein deglycase activity
HUO02_RS13610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUO02_RS13615	COG1378	Sugar-specific transcriptional regulator TrmB
HUO02_RS13635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUO02_RS13640	COG0454	-acetyltransferase
HUO02_RS13645	COG0517	IMP dehydrogenase activity
HUO02_RS13650	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUO02_RS13655	COG1360	Flagellar Motor Protein
HUO02_RS13660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUO02_RS13665	COG1609	Transcriptional regulator
HUO02_RS13670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUO02_RS13670	COG1605	Chorismate mutase
HUO02_RS13675	COG3118	belongs to the thioredoxin family
HUO02_RS13680	COG4980	gas vesicle protein
HUO02_RS13685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HUO02_RS13695	COG1674	ftsk spoiiie
HUO02_RS13700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO02_RS13710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS13720	COG1363	Peptidase, m42
HUO02_RS13725	COG5584	Small secreted protein
HUO02_RS13730	COG0281	malic enzyme
HUO02_RS13735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO02_RS13750	COG0510	thiamine kinase activity
HUO02_RS13755	COG1597	lipid kinase activity
HUO02_RS13765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HUO02_RS13770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO02_RS13775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO02_RS13780	COG2252	PERMEase
HUO02_RS13785	COG4473	ABC transporter
HUO02_RS13790	COG1131	(ABC) transporter
HUO02_RS13795	COG1349	DNA-binding transcription factor activity
HUO02_RS13800	COG1187	pseudouridine synthase activity
HUO02_RS13805	COG2244	polysaccharide biosynthetic process
HUO02_RS13810	COG2081	HI0933 family
HUO02_RS13815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO02_RS13825	COG1609	Transcriptional regulator
HUO02_RS13830	COG1653	transport
HUO02_RS13835	COG1175	transmembrane transport
HUO02_RS13840	COG0395	ABC-type sugar transport system, permease component
HUO02_RS13845	COG1486	melibiose metabolic process
HUO02_RS13855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO02_RS13870	COG2202	Pas domain
HUO02_RS13870	COG1366	Belongs to the anti-sigma-factor antagonist family
HUO02_RS13875	COG2814	Major facilitator Superfamily
HUO02_RS13880	COG5522	Integral membrane protein (intg_mem_TP0381)
HUO02_RS13885	COG0577	efflux transmembrane transporter activity
HUO02_RS13890	COG1136	(ABC) transporter
HUO02_RS13895	COG2205	protein histidine kinase activity
HUO02_RS13900	COG0745	RESPONSE REGULATOR receiver
HUO02_RS13905	COG0577	efflux transmembrane transporter activity
HUO02_RS13910	COG1136	(ABC) transporter
HUO02_RS13930	COG1131	(ABC) transporter
HUO02_RS13935	COG1725	Transcriptional regulator
HUO02_RS13950	COG0640	Transcriptional regulator
HUO02_RS13975	COG0477	Major facilitator Superfamily
HUO02_RS13980	COG1242	4 iron, 4 sulfur cluster binding
HUO02_RS13985	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUO02_RS13995	COG0584	glycerophosphoryl diester phosphodiesterase
HUO02_RS14005	COG2267	carboxylic ester hydrolase activity
HUO02_RS14010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUO02_RS14015	COG1113	amino acid transport
HUO02_RS14020	COG0367	asparagine synthase
HUO02_RS14040	COG1506	peptidase
HUO02_RS14045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUO02_RS14050	COG1116	anion transmembrane transporter activity
HUO02_RS14055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUO02_RS14060	COG0494	nUDIX hydrolase
HUO02_RS14065	COG4824	toxin secretion phage lysis holin
HUO02_RS14070	COG0783	Belongs to the Dps family
HUO02_RS14095	COG0288	reversible hydration of carbon dioxide
HUO02_RS14105	COG1271	oxidase subunit
HUO02_RS14110	COG1294	oxidase, subunit
HUO02_RS14120	COG4948	Mandelate Racemase Muconate Lactonizing
HUO02_RS14130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUO02_RS14135	COG0596	Alpha beta hydrolase
HUO02_RS14145	COG1169	isochorismate synthase
HUO02_RS14150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUO02_RS14155	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HUO02_RS14280	COG3859	Proton-coupled thiamine transporter YuaJ
HUO02_RS14285	COG2268	Band 7 protein
HUO02_RS14290	COG1585	Membrane protein implicated in regulation of membrane protease activity
HUO02_RS14295	COG2318	DinB family
HUO02_RS14305	COG1454	alcohol dehydrogenase
HUO02_RS14310	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS14315	COG1510	regulation of RNA biosynthetic process
HUO02_RS14325	COG0569	domain protein
HUO02_RS14330	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUO02_RS14335	COG1017	nitric oxide dioxygenase activity
HUO02_RS14335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUO02_RS14360	COG0628	permease
HUO02_RS14365	COG0673	inositol 2-dehydrogenase activity
HUO02_RS14370	COG0693	protein deglycase activity
HUO02_RS14375	COG0840	transmembrane signaling receptor activity
HUO02_RS14380	COG0840	transmembrane signaling receptor activity
HUO02_RS14385	COG0840	transmembrane signaling receptor activity
HUO02_RS14390	COG0840	transmembrane signaling receptor activity
HUO02_RS14405	COG2070	2-Nitropropane dioxygenase
HUO02_RS14410	COG0432	Pfam Uncharacterised protein family UPF0047
HUO02_RS14415	COG0366	Alpha amylase catalytic
HUO02_RS14420	COG1253	flavin adenine dinucleotide binding
HUO02_RS14425	COG2738	Putative neutral zinc metallopeptidase
HUO02_RS14440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUO02_RS14465	COG1335	isochorismatase
HUO02_RS14470	COG1979	alcohol dehydrogenase
HUO02_RS14475	COG1979	alcohol dehydrogenase
HUO02_RS14480	COG2155	Conserved Protein
HUO02_RS14485	COG1098	S1 RNA binding domain
HUO02_RS14490	COG0436	Aminotransferase
HUO02_RS14495	COG1522	sequence-specific DNA binding
HUO02_RS14500	COG2267	carboxylic ester hydrolase activity
HUO02_RS14510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUO02_RS14515	COG2205	protein histidine kinase activity
HUO02_RS14525	COG5018	Exonuclease
HUO02_RS14530	COG2814	Major facilitator Superfamily
HUO02_RS14535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO02_RS14540	COG3011	Protein conserved in bacteria
HUO02_RS14550	COG3290	protein histidine kinase activity
HUO02_RS14555	COG4565	transcriptional regulatory protein
HUO02_RS14585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUO02_RS14585	COG2111	Na H antiporter
HUO02_RS14590	COG2111	Na H antiporter
HUO02_RS14595	COG1006	Multisubunit Na H antiporter MnhC subunit
HUO02_RS14600	COG0651	ATP synthesis coupled electron transport
HUO02_RS14605	COG1863	multisubunit Na H antiporter MnhE subunit
HUO02_RS14610	COG2212	antiporter activity
HUO02_RS14615	COG1320	monovalent cation:proton antiporter activity
HUO02_RS14620	COG2050	protein possibly involved in aromatic compounds catabolism
HUO02_RS14625	COG2197	response regulator
HUO02_RS14630	COG4585	Histidine kinase
HUO02_RS14655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUO02_RS14660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUO02_RS14665	COG1335	isochorismatase
HUO02_RS14670	COG5506	Protein of unknown function (DUF1694)
HUO02_RS14685	COG0628	permease
HUO02_RS14695	COG1418	mRNA catabolic process
HUO02_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS14710	COG1511	domain protein
HUO02_RS14715	COG1674	ftsk spoiiie
HUO02_RS14715	COG0433	COG0433 Predicted ATPase
HUO02_RS14720	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUO02_RS14725	COG5417	Belongs to the EsaB family
HUO02_RS14730	COG4842	Belongs to the WXG100 family
HUO02_RS14735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUO02_RS14735	COG2508	Transcriptional regulator
HUO02_RS14740	COG0686	Belongs to the AlaDH PNT family
HUO02_RS14745	COG5634	Uncharacterized conserved protein (DUF2278)
HUO02_RS14750	COG3251	PFAM MbtH domain protein
HUO02_RS14755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUO02_RS14760	COG3433	isochorismatase activity
HUO02_RS14760	COG1535	isochorismatase
HUO02_RS14765	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUO02_RS14770	COG1169	isochorismate synthase
HUO02_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS14780	COG2819	hydrolase of the alpha beta superfamily
HUO02_RS14785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUO02_RS14790	COG1268	BioY protein
HUO02_RS14795	COG2056	Na+-H+ antiporter family
HUO02_RS14805	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HUO02_RS14810	COG3584	3D domain protein
HUO02_RS14825	COG1252	NADH dehydrogenase
HUO02_RS14855	COG1131	(ABC) transporter
HUO02_RS14875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO02_RS14880	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUO02_RS14885	COG0316	Belongs to the HesB IscA family
HUO02_RS14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO02_RS14905	COG1252	NADH dehydrogenase
HUO02_RS14910	COG4837	Protein of unknown function (DUF1462)
HUO02_RS14915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUO02_RS14920	COG1506	peptidase
HUO02_RS14920	COG0823	Involved in the tonB-independent uptake of proteins
HUO02_RS14920	COG4946	Tricorn protease homolog
HUO02_RS14930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUO02_RS14935	COG0460	homoserine dehydrogenase
HUO02_RS14940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUO02_RS14945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUO02_RS14950	COG0647	UMP catabolic process
HUO02_RS14955	COG2445	Protein of unknown function DUF86
HUO02_RS14960	COG4470	Protein conserved in bacteria
HUO02_RS14970	COG0739	heme binding
HUO02_RS14980	COG0737	Belongs to the 5'-nucleotidase family
HUO02_RS14985	COG0730	response to heat
HUO02_RS14990	COG1801	Protein of unknown function DUF72
HUO02_RS15005	COG2508	Transcriptional regulator
HUO02_RS15015	COG2814	Major facilitator Superfamily
HUO02_RS15020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUO02_RS15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO02_RS15030	COG2356	endonuclease I
HUO02_RS15035	COG3842	ATPase activity
HUO02_RS15040	COG2188	Transcriptional regulator
HUO02_RS15045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO02_RS15050	COG0395	ABC-type sugar transport system, permease component
HUO02_RS15055	COG1175	transmembrane transport
HUO02_RS15060	COG1653	transport
HUO02_RS15065	COG2222	sugar isomerase
HUO02_RS15070	COG0789	Transcriptional regulator
HUO02_RS15085	COG0322	excinuclease ABC activity
HUO02_RS15090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO02_RS15095	COG2226	methyltransferase
HUO02_RS15105	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS15110	COG0719	Fe-S assembly protein
HUO02_RS15115	COG0822	iron-sulfur transferase activity
HUO02_RS15120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUO02_RS15125	COG0719	Fe-S assembly protein
HUO02_RS15130	COG0396	ATPase activity
HUO02_RS15140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUO02_RS15145	COG1464	Belongs to the NlpA lipoprotein family
HUO02_RS15150	COG2011	ABC-type metal ion transport system permease component
HUO02_RS15155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUO02_RS15165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO02_RS15170	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUO02_RS15185	COG1393	Belongs to the ArsC family
HUO02_RS15190	COG1960	acyl-CoA dehydrogenase activity
HUO02_RS15195	COG0183	Belongs to the thiolase family
HUO02_RS15200	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUO02_RS15200	COG1024	Enoyl-CoA hydratase
HUO02_RS15220	COG5577	PFAM Coat F domain
HUO02_RS15225	COG1846	Transcriptional regulator
HUO02_RS15230	COG0477	Major facilitator Superfamily
HUO02_RS15235	COG1942	4-Oxalocrotonate Tautomerase
HUO02_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS15245	COG0583	DNA-binding transcription factor activity
HUO02_RS15255	COG0583	DNA-binding transcription factor activity
HUO02_RS15275	COG1120	ATPase activity
HUO02_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS15295	COG0783	Belongs to the Dps family
HUO02_RS15300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO02_RS15305	COG0745	RESPONSE REGULATOR receiver
HUO02_RS15310	COG2770	Histidine kinase
HUO02_RS15310	COG2205	protein histidine kinase activity
HUO02_RS15320	COG1309	transcriptional regulator
HUO02_RS15325	COG0114	fumarate hydratase activity
HUO02_RS15335	COG0697	spore germination
HUO02_RS15340	COG0814	amino acid
HUO02_RS15350	COG2197	response regulator
HUO02_RS15355	COG4585	Histidine kinase
HUO02_RS15360	COG4758	membrane
HUO02_RS15365	COG3595	metallopeptidase activity
HUO02_RS15370	COG1842	Phage shock protein A
HUO02_RS15375	COG4758	membrane
HUO02_RS15380	COG2814	Major facilitator Superfamily
HUO02_RS15385	COG2096	Adenosyltransferase
HUO02_RS15390	COG1120	ATPase activity
HUO02_RS15395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS15400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO02_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS15410	COG3386	PFAM SMP-30 Gluconolaconase
HUO02_RS15415	COG2205	protein histidine kinase activity
HUO02_RS15420	COG0745	RESPONSE REGULATOR receiver
HUO02_RS15430	COG1191	sigma factor activity
HUO02_RS15440	COG2140	Oxalate decarboxylase
HUO02_RS15450	COG1120	ATPase activity
HUO02_RS15455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS15460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS15465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO02_RS15470	COG0531	amino acid
HUO02_RS15480	COG1988	membrane-bound metal-dependent
HUO02_RS15485	COG1368	sulfuric ester hydrolase activity
HUO02_RS15490	COG1910	domain protein
HUO02_RS15495	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUO02_RS15500	COG4149	molybdate abc transporter
HUO02_RS15505	COG2197	response regulator
HUO02_RS15510	COG3850	Histidine kinase
HUO02_RS15515	COG1131	(ABC) transporter
HUO02_RS15525	COG0842	Transport permease protein
HUO02_RS15530	COG0656	L-ascorbic acid biosynthetic process
HUO02_RS15550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUO02_RS15555	COG3973	AAA domain
HUO02_RS15560	COG2860	membrane
HUO02_RS15570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUO02_RS15575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUO02_RS15580	COG2217	Heavy metal translocating P-type atpase
HUO02_RS15585	COG2217	Heavy metal translocating P-type atpase
HUO02_RS15590	COG2608	mercury ion transmembrane transporter activity
HUO02_RS15595	COG1937	Protein conserved in bacteria
HUO02_RS15600	COG0673	inositol 2-dehydrogenase activity
HUO02_RS15615	COG2814	Major facilitator Superfamily
HUO02_RS15630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS15635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUO02_RS15640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS15645	COG1126	abc transporter atp-binding protein
HUO02_RS15650	COG0765	amino acid transport
HUO02_RS15655	COG0765	amino acid transport
HUO02_RS15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO02_RS15670	COG0454	-acetyltransferase
HUO02_RS15675	COG0583	DNA-binding transcription factor activity
HUO02_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS15685	COG2732	(Barnase) inhibitor
HUO02_RS15700	COG0557	exoribonuclease II activity
HUO02_RS15705	COG1647	Serine aminopeptidase, S33
HUO02_RS15710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUO02_RS15715	COG1476	TRANSCRIPTIONal
HUO02_RS15720	COG1396	sequence-specific DNA binding
HUO02_RS15725	COG1396	sequence-specific DNA binding
HUO02_RS15730	COG1733	regulation of RNA biosynthetic process
HUO02_RS15755	COG1131	(ABC) transporter
HUO02_RS15760	COG1174	glycine betaine transport
HUO02_RS15765	COG1732	Glycine betaine
HUO02_RS15770	COG1174	glycine betaine transport
HUO02_RS15775	COG1125	glycine betaine transport
HUO02_RS15775	COG0517	IMP dehydrogenase activity
HUO02_RS15780	COG1510	regulation of RNA biosynthetic process
HUO02_RS15785	COG1174	glycine betaine transport
HUO02_RS15790	COG1732	Glycine betaine
HUO02_RS15795	COG1174	glycine betaine transport
HUO02_RS15800	COG1125	glycine betaine transport
HUO02_RS15800	COG0517	IMP dehydrogenase activity
HUO02_RS15805	COG1510	regulation of RNA biosynthetic process
HUO02_RS15810	COG2095	MarC family integral membrane protein
HUO02_RS15815	COG3064	Membrane
HUO02_RS15820	COG4640	response to antibiotic
HUO02_RS15825	COG0456	acetyltransferase
HUO02_RS15840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUO02_RS15855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUO02_RS15860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO02_RS15865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUO02_RS15875	COG2234	aminopeptidase activity
HUO02_RS15895	COG0126	phosphoglycerate kinase activity
HUO02_RS15900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUO02_RS15905	COG2390	Transcriptional regulator
HUO02_RS15910	COG2814	Major facilitator Superfamily
HUO02_RS15915	COG1609	Transcriptional regulator
HUO02_RS15920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS15930	COG0583	DNA-binding transcription factor activity
HUO02_RS15935	COG0697	spore germination
HUO02_RS15940	COG1113	amino acid transport
HUO02_RS15950	COG1609	Transcriptional regulator
HUO02_RS15960	COG0561	phosphatase activity
HUO02_RS15965	COG1737	Transcriptional regulator
HUO02_RS15970	COG1070	Carbohydrate kinase
HUO02_RS15995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO02_RS16000	COG2186	Transcriptional regulator
HUO02_RS16005	COG1620	l-lactate permease
HUO02_RS16010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUO02_RS16020	COG5039	Polysaccharide pyruvyl transferase
HUO02_RS16025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUO02_RS16030	COG0110	maltose O-acetyltransferase activity
HUO02_RS16035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUO02_RS16040	COG2244	polysaccharide biosynthetic process
HUO02_RS16045	COG1216	Glycosyl transferase, family 2
HUO02_RS16050	COG5039	Polysaccharide pyruvyl transferase
HUO02_RS16055	COG1216	Glycosyl transferase, family 2
HUO02_RS16065	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS16070	COG1215	transferase activity, transferring glycosyl groups
HUO02_RS16075	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS16080	COG1086	Polysaccharide biosynthesis protein
HUO02_RS16085	COG0489	protein tyrosine kinase activity
HUO02_RS16090	COG3944	biosynthesis protein
HUO02_RS16095	COG1396	sequence-specific DNA binding
HUO02_RS16100	COG2272	Belongs to the type-B carboxylesterase lipase family
HUO02_RS16105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUO02_RS16110	COG2364	Membrane
HUO02_RS16115	COG0456	acetyltransferase
HUO02_RS16120	COG3479	Phenolic acid decarboxylase
HUO02_RS16170	COG2223	nitrite transmembrane transporter activity
HUO02_RS16175	COG1609	Transcriptional regulator
HUO02_RS16185	COG0583	DNA-binding transcription factor activity
HUO02_RS16190	COG2828	Protein conserved in bacteria
HUO02_RS16195	COG0477	Major facilitator Superfamily
HUO02_RS16195	COG2814	Major facilitator Superfamily
HUO02_RS16200	COG1611	Belongs to the LOG family
HUO02_RS16205	COG1694	Mazg nucleotide pyrophosphohydrolase
HUO02_RS16210	COG0659	secondary active sulfate transmembrane transporter activity
HUO02_RS16215	COG0288	reversible hydration of carbon dioxide
HUO02_RS16220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUO02_RS16225	COG4290	ribonuclease
HUO02_RS16230	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HUO02_RS16235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS16245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUO02_RS16255	COG1051	belongs to the nudix hydrolase family
HUO02_RS16260	COG0492	ferredoxin-NADP+ reductase activity
HUO02_RS16265	COG3883	PFAM NLP P60 protein
HUO02_RS16265	COG0791	NLP P60 protein
HUO02_RS16270	COG0457	Tetratricopeptide repeat
HUO02_RS16275	COG5002	protein histidine kinase activity
HUO02_RS16280	COG0745	RESPONSE REGULATOR receiver
HUO02_RS16285	COG1132	(ABC) transporter
HUO02_RS16290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUO02_RS16290	COG0140	phosphoribosyl-ATP diphosphatase activity
HUO02_RS16315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUO02_RS16330	COG4990	cell redox homeostasis
HUO02_RS16335	COG0110	maltose O-acetyltransferase activity
HUO02_RS16355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUO02_RS16365	COG2188	Transcriptional regulator
HUO02_RS16370	COG1309	transcriptional regulator
HUO02_RS16375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUO02_RS16380	COG1950	PFAM Membrane protein of
HUO02_RS16385	COG1983	PspC domain protein
HUO02_RS16390	COG3595	metallopeptidase activity
HUO02_RS16405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUO02_RS16415	COG4897	Protein conserved in bacteria
HUO02_RS16420	COG0574	Belongs to the PEP-utilizing enzyme family
HUO02_RS16420	COG3848	Pyruvate phosphate dikinase
HUO02_RS16425	COG1309	transcriptional regulator
HUO02_RS16430	COG2814	Major facilitator Superfamily
HUO02_RS16435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO02_RS16445	COG0793	Belongs to the peptidase S41A family
HUO02_RS16445	COG3409	Peptidoglycan-binding domain 1 protein
HUO02_RS16450	COG3420	alginic acid biosynthetic process
HUO02_RS16455	COG2177	Part of the ABC transporter FtsEX involved in
HUO02_RS16460	COG2884	Cell division ATP-binding protein ftsE
HUO02_RS16465	COG2010	Cytochrome c
HUO02_RS16470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS16485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUO02_RS16500	COG1516	flagellar protein fliS
HUO02_RS16505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUO02_RS16510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO02_RS16530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO02_RS16535	COG1256	bacterial-type flagellum assembly
HUO02_RS16535	COG4786	Flagellar basal body rod
HUO02_RS16540	COG3418	PFAM FlgN family protein
HUO02_RS16545	COG2747	anti-sigma28 factor FlgM
HUO02_RS16555	COG1040	competence protein
HUO02_RS16565	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUO02_RS16570	COG1307	EDD domain protein, DegV family
HUO02_RS16575	COG2197	response regulator
HUO02_RS16580	COG4585	Histidine kinase
HUO02_RS16585	COG1739	Uncharacterized protein family UPF0029
HUO02_RS16590	COG1316	TRANSCRIPTIONal
HUO02_RS16595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUO02_RS16600	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS16605	COG1215	transferase activity, transferring glycosyl groups
HUO02_RS16610	COG3206	protein involved in exopolysaccharide biosynthesis
HUO02_RS16615	COG3307	-O-antigen
HUO02_RS16620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUO02_RS16625	COG0297	glycogen (starch) synthase activity
HUO02_RS16625	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS16630	COG2244	polysaccharide biosynthetic process
HUO02_RS16640	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUO02_RS16640	COG2247	cell wall binding repeat
HUO02_RS16645	COG2385	sporulation resulting in formation of a cellular spore
HUO02_RS16645	COG2247	cell wall binding repeat
HUO02_RS16655	COG1316	TRANSCRIPTIONal
HUO02_RS16660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUO02_RS16665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUO02_RS16670	COG1134	teichoic acid transport
HUO02_RS16675	COG1682	transport, permease protein
HUO02_RS16680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUO02_RS16690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUO02_RS16695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUO02_RS16700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUO02_RS16705	COG4193	domain, Protein
HUO02_RS16710	COG1482	cell wall glycoprotein biosynthetic process
HUO02_RS16715	COG0697	spore germination
HUO02_RS16720	COG0814	amino acid
HUO02_RS16730	COG1215	transferase activity, transferring glycosyl groups
HUO02_RS16735	COG2814	Major facilitator Superfamily
HUO02_RS16740	COG1316	TRANSCRIPTIONal
HUO02_RS16745	COG0561	phosphatase activity
HUO02_RS16750	COG2433	Pfam Transposase IS66
HUO02_RS16755	COG0791	NLP P60 protein
HUO02_RS16765	COG2843	Capsule synthesis protein
HUO02_RS16775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUO02_RS16785	COG0814	amino acid
HUO02_RS16795	COG1609	Transcriptional regulator
HUO02_RS16800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO02_RS16810	COG1129	ABC transporter
HUO02_RS16815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUO02_RS16820	COG1879	ABC-type sugar transport system periplasmic component
HUO02_RS16825	COG3103	Sh3 type 3 domain protein
HUO02_RS16830	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUO02_RS16835	COG3527	Alpha-acetolactate decarboxylase
HUO02_RS16840	COG0028	Belongs to the TPP enzyme family
HUO02_RS16845	COG0583	DNA-binding transcription factor activity
HUO02_RS16850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUO02_RS16865	COG5337	Spore coat protein CotH
HUO02_RS16875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUO02_RS16885	COG0405	Gamma-glutamyltransferase
HUO02_RS16890	COG1522	sequence-specific DNA binding
HUO02_RS16895	COG2059	Chromate
HUO02_RS16900	COG2059	Chromate
HUO02_RS16990	COG5444	nuclease activity
HUO02_RS17005	COG3878	Protein conserved in bacteria
HUO02_RS17010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUO02_RS17015	COG4464	protein tyrosine phosphatase activity
HUO02_RS17020	COG0489	protein tyrosine kinase activity
HUO02_RS17025	COG3944	biosynthesis protein
HUO02_RS17035	COG4715	Zinc finger, swim domain protein
HUO02_RS17040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUO02_RS17045	COG0561	phosphatase activity
HUO02_RS17050	COG1349	DNA-binding transcription factor activity
HUO02_RS17055	COG0629	single-stranded DNA binding
HUO02_RS17080	COG0457	Tetratricopeptide repeat
HUO02_RS17085	COG4786	Flagellar basal body rod
HUO02_RS17090	COG4786	Flagellar basal body rod
HUO02_RS17095	COG1077	Cell shape determining protein MreB Mrl
HUO02_RS17100	COG1609	Transcriptional regulator
HUO02_RS17105	COG1846	Transcriptional regulator
HUO02_RS17110	COG2814	Major facilitator Superfamily
HUO02_RS17115	COG1953	Uracil, thiamine, allantoin
HUO02_RS17120	COG0477	Major facilitator Superfamily
HUO02_RS17125	COG1335	isochorismatase
HUO02_RS17130	COG0004	ammonium transporteR
HUO02_RS17135	COG0347	Belongs to the P(II) protein family
HUO02_RS17140	COG0772	Belongs to the SEDS family
HUO02_RS17145	COG0671	phosphoesterase, PA-phosphatase related
HUO02_RS17155	COG0739	heme binding
HUO02_RS17160	COG1247	-acetyltransferase
HUO02_RS17175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO02_RS17185	COG0726	polysaccharide deacetylase
HUO02_RS17190	COG1959	2 iron, 2 sulfur cluster binding
HUO02_RS17205	COG0831	urea catabolic process
HUO02_RS17210	COG3237	CsbD-like
HUO02_RS17215	COG1994	Peptidase M50
HUO02_RS17220	COG0457	Tetratricopeptide repeat
HUO02_RS17230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUO02_RS17240	COG2304	oxidoreductase activity
HUO02_RS17245	COG2304	oxidoreductase activity
HUO02_RS17250	COG2385	sporulation resulting in formation of a cellular spore
HUO02_RS17255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUO02_RS17265	COG4836	Membrane
HUO02_RS17335	COG0698	ribose 5-phosphate isomerase
HUO02_RS17340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUO02_RS17350	COG0009	L-threonylcarbamoyladenylate synthase
HUO02_RS17355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUO02_RS17375	COG2890	protein-(glutamine-N5) methyltransferase activity
HUO02_RS17380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUO02_RS17385	COG0346	lactoylglutathione lyase activity
HUO02_RS17390	COG0789	Transcriptional regulator
HUO02_RS17395	COG0679	Auxin Efflux Carrier
HUO02_RS17400	COG0281	malic enzyme
HUO02_RS17415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUO02_RS17420	COG1494	fructose-1,6-bisphosphatase
HUO02_RS17425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUO02_RS17435	COG0191	fructose-bisphosphate aldolase activity
HUO02_RS17440	COG2204	response regulator
HUO02_RS17445	COG4821	SIS domain
HUO02_RS17460	COG2181	nitrate reductase activity
HUO02_RS17460	COG0247	lactate metabolic process
HUO02_RS17465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO02_RS17480	COG1132	(ABC) transporter
HUO02_RS17485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO02_RS17495	COG2181	nitrate reductase activity
HUO02_RS17500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUO02_RS17505	COG1140	nitrate reductase beta subunit
HUO02_RS17510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HUO02_RS17515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO02_RS17525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO02_RS17530	COG2223	nitrite transmembrane transporter activity
HUO02_RS17540	COG4506	Protein conserved in bacteria
HUO02_RS17550	COG3391	amine dehydrogenase activity
HUO02_RS17555	COG3391	amine dehydrogenase activity
HUO02_RS17560	COG0457	Tetratricopeptide repeat
HUO02_RS17600	COG0010	Belongs to the arginase family
HUO02_RS17605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUO02_RS17610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO02_RS17625	COG1994	Peptidase M50
HUO02_RS17630	COG1942	4-Oxalocrotonate Tautomerase
HUO02_RS17635	COG1846	Transcriptional regulator
HUO02_RS17640	COG0531	amino acid
HUO02_RS17645	COG3465	dGTPase activity
HUO02_RS17650	COG1078	dGTPase activity
HUO02_RS17665	COG1695	Transcriptional regulator
HUO02_RS17675	COG1131	(ABC) transporter
HUO02_RS17680	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HUO02_RS17710	COG0583	DNA-binding transcription factor activity
HUO02_RS17715	COG2855	membrane
HUO02_RS17720	COG0280	phosphate acetyltransferase
HUO02_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS17735	COG0436	Aminotransferase
HUO02_RS17765	COG2814	Major facilitator Superfamily
HUO02_RS17770	COG2814	Major facilitator Superfamily
HUO02_RS17775	COG0833	amino acid
HUO02_RS17780	COG4187	Peptidase family M20/M25/M40
HUO02_RS17785	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS17790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUO02_RS17795	COG2205	protein histidine kinase activity
HUO02_RS17800	COG0745	RESPONSE REGULATOR receiver
HUO02_RS17815	COG1131	(ABC) transporter
HUO02_RS17820	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HUO02_RS17825	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUO02_RS17830	COG1088	dTDP-glucose 4,6-dehydratase activity
HUO02_RS17835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUO02_RS17840	COG3980	spore coat polysaccharide biosynthesis protein
HUO02_RS17845	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUO02_RS17850	COG2089	acid synthase
HUO02_RS17855	COG0456	acetyltransferase
HUO02_RS17860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUO02_RS17865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUO02_RS17870	COG0463	Glycosyl transferase, family 2
HUO02_RS17880	COG2363	Small membrane protein
HUO02_RS17885	COG2233	PERMEase
HUO02_RS17900	COG1216	Glycosyl transferase, family 2
HUO02_RS17915	COG1695	Transcriptional regulator
HUO02_RS17920	COG0351	phosphomethylpyrimidine kinase
HUO02_RS17930	COG1621	beta-fructofuranosidase activity
HUO02_RS17935	COG1263	PTS System
HUO02_RS17935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS17940	COG3711	transcriptional antiterminator
HUO02_RS17950	COG1404	Belongs to the peptidase S8 family
HUO02_RS17955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO02_RS17965	COG0778	Nitroreductase
HUO02_RS17970	COG0772	Belongs to the SEDS family
HUO02_RS17975	COG0454	-acetyltransferase
HUO02_RS17995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUO02_RS18000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUO02_RS18005	COG2261	transglycosylase associated protein
HUO02_RS18010	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUO02_RS18015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUO02_RS18020	COG2246	polysaccharide biosynthetic process
HUO02_RS18025	COG1309	transcriptional regulator
HUO02_RS18045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUO02_RS18050	COG2837	iron assimilation
HUO02_RS18055	COG2822	iron ion transport
HUO02_RS18070	COG0583	DNA-binding transcription factor activity
HUO02_RS18080	COG1346	cytolysis
HUO02_RS18085	COG4895	conserved protein (DUF2196)
HUO02_RS18090	COG0789	Transcriptional regulator
HUO02_RS18095	COG5504	Zn-dependent protease
HUO02_RS18100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUO02_RS18105	COG0346	lactoylglutathione lyase activity
HUO02_RS18110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS18115	COG1404	Belongs to the peptidase S8 family
HUO02_RS18120	COG1442	glycosyl transferase family 8
HUO02_RS18125	COG2357	RelA SpoT domain protein
HUO02_RS18130	COG1575	Belongs to the MenA family. Type 1 subfamily
HUO02_RS18145	COG1696	Membrane protein involved in D-alanine export
HUO02_RS18155	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HUO02_RS18160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO02_RS18165	COG1486	melibiose metabolic process
HUO02_RS18170	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUO02_RS18175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS18180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS18185	COG3711	transcriptional antiterminator
HUO02_RS18185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO02_RS18195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS18200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO02_RS18210	COG0640	Transcriptional regulator
HUO02_RS18215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUO02_RS18220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS18225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUO02_RS18230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO02_RS18235	COG2723	6-phospho-beta-galactosidase activity
HUO02_RS18240	COG1940	carbohydrate kinase activity
HUO02_RS18245	COG1482	cell wall glycoprotein biosynthetic process
HUO02_RS18255	COG0753	catalase activity
HUO02_RS18260	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HUO02_RS18265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUO02_RS18270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUO02_RS18275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUO02_RS18280	COG4988	ABC transporter
HUO02_RS18285	COG1294	oxidase, subunit
HUO02_RS18290	COG1271	oxidase subunit
HUO02_RS18295	COG3493	citrate carrier protein
HUO02_RS18300	COG0726	polysaccharide deacetylase
HUO02_RS18305	COG3842	ATPase activity
HUO02_RS18310	COG2508	Transcriptional regulator
HUO02_RS18315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS18325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUO02_RS18340	COG4894	glucomannan catabolic process
HUO02_RS18345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUO02_RS18350	COG0500	methyltransferase
HUO02_RS18355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO02_RS18370	COG0753	catalase activity
HUO02_RS18370	COG0693	protein deglycase activity
HUO02_RS18375	COG2851	Citrate transporter
HUO02_RS18380	COG2273	Hydrolase Family 16
HUO02_RS18385	COG3711	transcriptional antiterminator
HUO02_RS18390	COG2270	Major facilitator Superfamily
HUO02_RS18395	COG0513	Belongs to the DEAD box helicase family
HUO02_RS18445	COG0697	spore germination
HUO02_RS18450	COG0589	response to stress
HUO02_RS18455	COG2723	6-phospho-beta-galactosidase activity
HUO02_RS18460	COG1263	PTS System
HUO02_RS18460	COG2190	(PTS) system
HUO02_RS18460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO02_RS18470	COG0494	nUDIX hydrolase
HUO02_RS18475	COG3507	Belongs to the glycosyl hydrolase 43 family
HUO02_RS18500	COG0010	Belongs to the arginase family
HUO02_RS18505	COG0833	amino acid
HUO02_RS18510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUO02_RS18515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO02_RS18525	COG2390	Transcriptional regulator
HUO02_RS18530	COG0561	phosphatase activity
HUO02_RS18560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO02_RS18570	COG5294	Protein conserved in bacteria
HUO02_RS18575	COG0577	efflux transmembrane transporter activity
HUO02_RS18580	COG1136	(ABC) transporter
HUO02_RS18585	COG2205	protein histidine kinase activity
HUO02_RS18590	COG0745	RESPONSE REGULATOR receiver
HUO02_RS18595	COG2205	protein histidine kinase activity
HUO02_RS18600	COG0745	RESPONSE REGULATOR receiver
HUO02_RS18630	COG1082	Xylose isomerase domain protein TIM barrel
HUO02_RS18640	COG2814	Major facilitator Superfamily
HUO02_RS18670	COG1349	DNA-binding transcription factor activity
HUO02_RS18675	COG0667	Aldo Keto reductase
HUO02_RS18680	COG2814	Major facilitator Superfamily
HUO02_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS18695	COG2197	response regulator
HUO02_RS18700	COG4585	Histidine kinase
HUO02_RS18705	COG3239	Fatty acid desaturase
HUO02_RS18710	COG1309	transcriptional regulator
HUO02_RS18715	COG1012	belongs to the aldehyde dehydrogenase family
HUO02_RS18720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUO02_RS18730	COG0640	Transcriptional regulator
HUO02_RS18735	COG2814	Major facilitator Superfamily
HUO02_RS18740	COG1714	RDD family
HUO02_RS18750	COG0450	alkyl hydroperoxide reductase
HUO02_RS18755	COG3634	alkyl hydroperoxide reductase activity
HUO02_RS18760	COG3177	Filamentation induced by cAMP protein fic
HUO02_RS18765	COG1113	amino acid transport
HUO02_RS18775	COG2080	2 iron, 2 sulfur cluster binding
HUO02_RS18790	COG2068	MobA-Related Protein
HUO02_RS18795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUO02_RS18860	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HUO02_RS18865	COG0667	Aldo Keto reductase
HUO02_RS18870	COG0456	acetyltransferase
HUO02_RS18875	COG0457	Tetratricopeptide repeat
HUO02_RS18880	COG0010	Belongs to the arginase family
HUO02_RS18885	COG0833	amino acid
HUO02_RS18890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUO02_RS18895	COG3829	transcription factor binding
HUO02_RS18905	COG0488	(ABC) transporter
HUO02_RS18920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUO02_RS18925	COG3850	Histidine kinase
HUO02_RS18925	COG5002	protein histidine kinase activity
HUO02_RS18930	COG0745	RESPONSE REGULATOR receiver
HUO02_RS18935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO02_RS18940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUO02_RS18945	COG4853	Protein conserved in bacteria
HUO02_RS18950	COG4863	YycH protein
HUO02_RS18955	COG5002	protein histidine kinase activity
HUO02_RS18960	COG0745	RESPONSE REGULATOR receiver
HUO02_RS18990	COG0346	lactoylglutathione lyase activity
HUO02_RS18995	COG0305	Participates in initiation and elongation during chromosome replication
HUO02_RS19010	COG3093	addiction module antidote protein HigA
HUO02_RS19015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUO02_RS19030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUO02_RS19035	COG0438	transferase activity, transferring glycosyl groups
HUO02_RS19055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HUO02_RS19060	COG4241	membrane
HUO02_RS19070	COG5577	PFAM Coat F domain
HUO02_RS19075	COG1733	regulation of RNA biosynthetic process
HUO02_RS19085	COG0697	spore germination
HUO02_RS19090	COG1621	beta-fructofuranosidase activity
HUO02_RS19095	COG1621	beta-fructofuranosidase activity
HUO02_RS19100	COG1802	Transcriptional regulator
HUO02_RS19105	COG2318	DinB family
HUO02_RS19115	COG0583	DNA-binding transcription factor activity
HUO02_RS19125	COG2814	Major facilitator Superfamily
HUO02_RS19130	COG0583	DNA-binding transcription factor activity
HUO02_RS19140	COG0778	Nitroreductase
HUO02_RS19145	COG1846	Transcriptional regulator
HUO02_RS19150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO02_RS19155	COG1846	Transcriptional regulator
HUO02_RS19160	COG2153	protein acetylation
HUO02_RS19170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUO02_RS19175	COG0583	DNA-binding transcription factor activity
HUO02_RS19180	COG1028	Short-chain dehydrogenase reductase Sdr
HUO02_RS19190	COG1331	Highly conserved protein containing a thioredoxin domain
HUO02_RS19210	COG0515	serine threonine protein kinase
HUO02_RS19210	COG2815	serine threonine protein kinase
HUO02_RS19215	COG1331	Highly conserved protein containing a thioredoxin domain
HUO02_RS19220	COG1266	CAAX protease self-immunity
HUO02_RS19225	COG2814	Major facilitator Superfamily
HUO02_RS19225	COG0477	Major facilitator Superfamily
HUO02_RS19230	COG0346	lactoylglutathione lyase activity
HUO02_RS19235	COG1609	Transcriptional regulator
HUO02_RS19240	COG0708	Exodeoxyribonuclease III
HUO02_RS19245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUO02_RS19250	COG2169	Transcriptional regulator
HUO02_RS19260	COG0629	single-stranded DNA binding
HUO02_RS19270	COG0012	GTP binding
HUO02_RS19275	COG0243	molybdopterin cofactor binding
HUO02_RS19280	COG4481	Protein conserved in bacteria
HUO02_RS19285	COG3949	Membrane
HUO02_RS19300	COG1475	DNA binding
HUO02_RS19305	COG1192	Involved in chromosome partitioning
HUO02_RS19330	COG1847	R3H domain protein
HUO02_RS19335	COG0706	membrane insertase activity