locus-tag	class	description
SB45_RS00010	COG0517	IMP dehydrogenase activity
SB45_RS00010	COG0516	GMP reductase activity
SB45_RS00015	COG1686	Belongs to the peptidase S11 family
SB45_RS00035	COG1929	Belongs to the glycerate kinase type-1 family
SB45_RS00045	COG1428	Deoxynucleoside kinase
SB45_RS00050	COG1428	Deoxynucleoside kinase
SB45_RS00055	COG1388	LysM domain
SB45_RS00055	COG3858	chitin binding
SB45_RS00060	COG1335	isochorismatase
SB45_RS00065	COG0590	tRNA wobble adenosine to inosine editing
SB45_RS00070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SB45_RS00075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SB45_RS00115	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
SB45_RS00120	COG3853	Toxic anion resistance protein (TelA)
SB45_RS00125	COG1982	Orn Lys Arg decarboxylase major
SB45_RS00135	COG3870	Protein conserved in bacteria
SB45_RS00140	COG1728	Protein conserved in bacteria
SB45_RS00145	COG0470	DNA polymerase III
SB45_RS00150	COG1774	PSP1 C-terminal conserved region
SB45_RS00160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SB45_RS00170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SB45_RS00175	COG2002	toxin-antitoxin pair type II binding
SB45_RS00180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB45_RS00180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB45_RS00185	COG0084	hydrolase, TatD family'
SB45_RS00190	COG3584	3D domain protein
SB45_RS00190	COG3583	domain protein
SB45_RS00195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SB45_RS00200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SB45_RS00210	COG4466	Protein conserved in bacteria
SB45_RS00225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB45_RS00230	COG0251	oxidation-reduction process
SB45_RS00245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SB45_RS00265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SB45_RS00270	COG2002	toxin-antitoxin pair type II binding
SB45_RS00275	COG2244	polysaccharide biosynthetic process
SB45_RS00280	COG3956	TIGRFAM MazG family protein
SB45_RS00285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SB45_RS00300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SB45_RS00305	COG1098	S1 RNA binding domain
SB45_RS00320	COG2208	phosphoserine phosphatase activity
SB45_RS00325	COG2304	oxidoreductase activity
SB45_RS00330	COG0515	serine threonine protein kinase
SB45_RS00335	COG0037	tRNA processing
SB45_RS00340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SB45_RS00345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SB45_RS00360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB45_RS00365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB45_RS00370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SB45_RS00375	COG0512	Glutamine amidotransferase of anthranilate synthase
SB45_RS00380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB45_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SB45_RS00390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SB45_RS00395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SB45_RS00400	COG1396	sequence-specific DNA binding
SB45_RS00405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB45_RS00410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SB45_RS00490	COG4463	regulation of RNA biosynthetic process
SB45_RS00495	COG3880	PFAM UvrB UvrC protein
SB45_RS00505	COG0542	response to heat
SB45_RS00510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SB45_RS00515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SB45_RS00520	COG4956	integral membrane protein (PIN domain superfamily)
SB45_RS00540	COG1045	serine acetyltransferase
SB45_RS00550	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SB45_RS00555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB45_RS00560	COG3688	RNA-binding protein containing a PIN domain
SB45_RS00565	COG1595	DNA-templated transcription, initiation
SB45_RS00575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB45_RS00580	COG0250	Participates in transcription elongation, termination and antitermination
SB45_RS00605	COG2813	Specifically methylates the guanine in position
SB45_RS00620	COG1358	cellular component organization or biogenesis
SB45_RS00645	COG0596	Alpha beta hydrolase
SB45_RS00750	COG0201	protein transport
SB45_RS00760	COG0024	Methionine aminopeptidase
SB45_RS00770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SB45_RS00795	COG1122	ATPase activity
SB45_RS00800	COG1122	ATPase activity
SB45_RS00805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB45_RS00825	COG2226	methyltransferase
SB45_RS00830	COG2318	DinB family
SB45_RS00840	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB45_RS00845	COG0489	protein tyrosine kinase activity
SB45_RS00855	COG2194	sulfuric ester hydrolase activity
SB45_RS00860	COG0726	polysaccharide deacetylase
SB45_RS00955	COG0738	Major facilitator superfamily
SB45_RS00960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SB45_RS00975	COG0659	secondary active sulfate transmembrane transporter activity
SB45_RS00980	COG0385	Bile acid
SB45_RS00985	COG2819	hydrolase of the alpha beta superfamily
SB45_RS00990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS01000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB45_RS01005	COG2207	Transcriptional regulator
SB45_RS01005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB45_RS01010	COG3876	Protein conserved in bacteria
SB45_RS01015	COG1472	Belongs to the glycosyl hydrolase 3 family
SB45_RS01020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB45_RS01025	COG1263	PTS System
SB45_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS01035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB45_RS01040	COG1683	Conserved Protein
SB45_RS01070	COG1595	DNA-templated transcription, initiation
SB45_RS01075	COG5662	AntiSigma factor
SB45_RS01080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB45_RS01085	COG4856	YbbR-like protein
SB45_RS01115	COG1346	cytolysis
SB45_RS01120	COG1380	Effector of murein hydrolase LrgA
SB45_RS01125	COG1846	Transcriptional regulator
SB45_RS01130	COG1113	amino acid transport
SB45_RS01135	COG1011	Hydrolase
SB45_RS01140	COG4585	Histidine kinase
SB45_RS01145	COG2197	response regulator
SB45_RS01150	COG1131	(ABC) transporter
SB45_RS01190	COG0531	amino acid
SB45_RS01195	COG0584	glycerophosphoryl diester phosphodiesterase
SB45_RS01200	COG2271	Major facilitator Superfamily
SB45_RS01210	COG2368	4-hydroxyphenylacetate
SB45_RS01220	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS01235	COG0371	Dehydrogenase
SB45_RS01245	COG1183	phosphatidylcholine synthase activity
SB45_RS01250	COG0586	Pfam SNARE associated Golgi protein
SB45_RS01255	COG0688	phosphatidylethanolamine metabolic process
SB45_RS01270	COG1301	dicarboxylic acid transport
SB45_RS01275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB45_RS01280	COG0833	amino acid
SB45_RS01285	COG2040	homocysteine
SB45_RS01290	COG1115	amino acid carrier protein
SB45_RS01295	COG2066	Belongs to the glutaminase family
SB45_RS01300	COG4191	Histidine kinase
SB45_RS01305	COG0784	Response regulator, receiver
SB45_RS01310	COG3173	Aminoglycoside phosphotransferase
SB45_RS01320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB45_RS01325	COG0778	Nitroreductase
SB45_RS01330	COG0346	lactoylglutathione lyase activity
SB45_RS01335	COG2259	Doxx family
SB45_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS01350	COG3773	Cell wall hydrolase
SB45_RS01355	COG3540	Alkaline phosphatase
SB45_RS01360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB45_RS01365	COG0805	protein transport
SB45_RS01375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB45_RS01380	COG0477	Major facilitator Superfamily
SB45_RS01385	COG1309	transcriptional regulator
SB45_RS01390	COG0252	asparaginase activity
SB45_RS01395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SB45_RS01400	COG3012	SEC-C Motif Domain Protein
SB45_RS01400	COG1405	negative regulation of cell septum assembly
SB45_RS01405	COG0667	Aldo Keto reductase
SB45_RS01415	COG1595	DNA-templated transcription, initiation
SB45_RS01420	COG1595	DNA-templated transcription, initiation
SB45_RS01425	COG1876	peptidase activity
SB45_RS01430	COG0457	Tetratricopeptide repeat
SB45_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS01440	COG0366	Alpha amylase catalytic
SB45_RS01445	COG0803	Belongs to the bacterial solute-binding protein 9 family
SB45_RS01450	COG1121	(ABC) transporter
SB45_RS01455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SB45_RS01460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS01465	COG2310	stress, protein
SB45_RS01470	COG2310	stress, protein
SB45_RS01475	COG2310	stress, protein
SB45_RS01480	COG0861	Integral membrane protein TerC family
SB45_RS01490	COG3853	Toxic anion resistance protein (TelA)
SB45_RS01495	COG0477	Major facilitator Superfamily
SB45_RS01500	COG4175	Glycine betaine
SB45_RS01500	COG0517	IMP dehydrogenase activity
SB45_RS01505	COG4176	ABC-type proline glycine betaine transport system permease component
SB45_RS01510	COG2113	Glycine betaine
SB45_RS01515	COG1473	amidohydrolase
SB45_RS01520	COG1288	antiporter activity
SB45_RS01530	COG0366	Alpha amylase catalytic
SB45_RS01540	COG2814	Major facilitator Superfamily
SB45_RS01545	COG1846	Transcriptional regulator
SB45_RS01550	COG1280	lysine exporter protein (LysE YggA)
SB45_RS01555	COG3403	YqcI/YcgG family
SB45_RS01560	COG1113	amino acid transport
SB45_RS01565	COG3665	Urea carboxylase-associated protein
SB45_RS01580	COG1660	Displays ATPase and GTPase activities
SB45_RS01585	COG1082	Xylose isomerase domain protein TIM barrel
SB45_RS01590	COG2271	Major facilitator Superfamily
SB45_RS01595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SB45_RS01600	COG3458	cephalosporin-C deacetylase activity
SB45_RS01605	COG3541	Predicted nucleotidyltransferase
SB45_RS01610	COG0506	proline dehydrogenase activity
SB45_RS01615	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS01620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB45_RS01625	COG2508	Transcriptional regulator
SB45_RS01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SB45_RS01635	COG1587	Uroporphyrinogen-III synthase
SB45_RS01640	COG2146	nitrite reductase [NAD(P)H] activity
SB45_RS01645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SB45_RS01650	COG0523	cobalamin synthesis protein
SB45_RS01655	COG1063	alcohol dehydrogenase
SB45_RS01660	COG1714	RDD family
SB45_RS01680	COG3209	COG3209 Rhs family protein
SB45_RS01685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB45_RS01690	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SB45_RS01695	COG1733	regulation of RNA biosynthetic process
SB45_RS01700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS01705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS01710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS01715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SB45_RS01730	COG2364	Membrane
SB45_RS01735	COG1126	abc transporter atp-binding protein
SB45_RS01740	COG0765	amino acid transport
SB45_RS01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS01750	COG0583	DNA-binding transcription factor activity
SB45_RS01755	COG0163	prenyltransferase activity
SB45_RS01760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SB45_RS01775	COG3104	oligopeptide transport
SB45_RS01780	COG5434	Belongs to the glycosyl hydrolase 28 family
SB45_RS01790	COG0697	spore germination
SB45_RS01800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB45_RS01805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS01810	COG0456	acetyltransferase
SB45_RS01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS01820	COG0765	amino acid transport
SB45_RS01825	COG1126	abc transporter atp-binding protein
SB45_RS01830	COG1473	amidohydrolase
SB45_RS01835	COG2079	MmgE PrpD family protein
SB45_RS01840	COG1136	(ABC) transporter
SB45_RS01845	COG0577	efflux transmembrane transporter activity
SB45_RS01850	COG0745	RESPONSE REGULATOR receiver
SB45_RS01855	COG5002	protein histidine kinase activity
SB45_RS01855	COG3850	Histidine kinase
SB45_RS01860	COG0457	Tetratricopeptide repeat
SB45_RS01870	COG0527	aspartate kinase activity
SB45_RS01875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS01880	COG4605	iron ion homeostasis
SB45_RS01885	COG4604	ABC transporter, ATP-binding protein
SB45_RS01890	COG4607	ABC-type enterochelin transport system periplasmic component
SB45_RS01895	COG2814	Major facilitator Superfamily
SB45_RS01900	COG1309	transcriptional regulator
SB45_RS01905	COG0778	Nitroreductase
SB45_RS01910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SB45_RS01915	COG0640	Transcriptional regulator
SB45_RS01920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB45_RS01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SB45_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS01935	COG4975	Glucose uptake
SB45_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS01945	COG4549	nuclear export factor GLE1
SB45_RS01950	COG2372	response to copper ion
SB45_RS01950	COG1276	copper resistance
SB45_RS01955	COG1349	DNA-binding transcription factor activity
SB45_RS01965	COG2213	PTS system mannitol-specific
SB45_RS01970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS01980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SB45_RS01985	COG0561	phosphatase activity
SB45_RS01995	COG1914	H( )-stimulated, divalent metal cation uptake system
SB45_RS02005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SB45_RS02010	COG1984	allophanate hydrolase subunit 2
SB45_RS02015	COG1414	Transcriptional regulator
SB45_RS02020	COG2755	lipolytic protein G-D-S-L family
SB45_RS02030	COG2329	Antibiotic biosynthesis monooxygenase
SB45_RS02035	COG0768	penicillin binding
SB45_RS02040	COG4989	oxidoreductase activity
SB45_RS02045	COG3711	transcriptional antiterminator
SB45_RS02050	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS02060	COG1917	Cupin 2, conserved barrel domain protein
SB45_RS02065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB45_RS02070	COG3871	stress protein (general stress protein 26)
SB45_RS02080	COG2814	Major facilitator Superfamily
SB45_RS02085	COG1522	sequence-specific DNA binding
SB45_RS02090	COG0551	DNA topoisomerase type I activity
SB45_RS02090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB45_RS02095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SB45_RS02100	COG3706	GGDEF domain
SB45_RS02105	COG5298	Protein conserved in bacteria
SB45_RS02110	COG1215	transferase activity, transferring glycosyl groups
SB45_RS02120	COG0531	amino acid
SB45_RS02125	COG0494	nUDIX hydrolase
SB45_RS02130	COG0028	Belongs to the TPP enzyme family
SB45_RS02160	COG1914	H( )-stimulated, divalent metal cation uptake system
SB45_RS02175	COG4876	unkown
SB45_RS02185	COG2076	Multidrug Resistance protein
SB45_RS02190	COG2217	Heavy metal translocating P-type atpase
SB45_RS02195	COG3729	General stress protein
SB45_RS02200	COG0662	Cupin 2, conserved barrel domain protein
SB45_RS02205	COG2329	Antibiotic biosynthesis monooxygenase
SB45_RS02215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SB45_RS02220	COG3290	protein histidine kinase activity
SB45_RS02225	COG4565	transcriptional regulatory protein
SB45_RS02230	COG1301	dicarboxylic acid transport
SB45_RS02235	COG0628	permease
SB45_RS02240	COG1131	(ABC) transporter
SB45_RS02245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB45_RS02255	COG1960	acyl-CoA dehydrogenase activity
SB45_RS02265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB45_RS02270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS02280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SB45_RS02285	COG0513	Belongs to the DEAD box helicase family
SB45_RS02290	COG3402	PFAM membrane-flanked domain
SB45_RS02295	COG3428	Bacterial PH domain
SB45_RS02300	COG0705	Rhomboid family
SB45_RS02310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SB45_RS02315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SB45_RS02320	COG0864	Transcriptional regulator
SB45_RS02325	COG2337	Toxic component of a toxin-antitoxin (TA) module
SB45_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS02335	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS02340	COG2172	sigma factor antagonist activity
SB45_RS02345	COG2208	phosphoserine phosphatase activity
SB45_RS02350	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS02360	COG1191	sigma factor activity
SB45_RS02365	COG2208	phosphoserine phosphatase activity
SB45_RS02370	COG2183	response to ionizing radiation
SB45_RS02415	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB45_RS02425	COG0477	Major facilitator Superfamily
SB45_RS02435	COG1764	response to oxidative stress
SB45_RS02440	COG1846	Transcriptional regulator
SB45_RS02450	COG2030	dehydratase
SB45_RS02460	COG1959	2 iron, 2 sulfur cluster binding
SB45_RS02465	COG2910	NAD(P)H-binding
SB45_RS02470	COG1278	Cold shock
SB45_RS02475	COG1937	Protein conserved in bacteria
SB45_RS02480	COG2210	Belongs to the sulfur carrier protein TusA family
SB45_RS02485	COG0425	Belongs to the sulfur carrier protein TusA family
SB45_RS02485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB45_RS02490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS02490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB45_RS02495	COG0425	Belongs to the sulfur carrier protein TusA family
SB45_RS02500	COG0730	response to heat
SB45_RS02505	COG1794	racemase activity, acting on amino acids and derivatives
SB45_RS02520	COG3621	Patatin-like phospholipase
SB45_RS02530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SB45_RS02535	COG1802	Transcriptional regulator
SB45_RS02540	COG0251	oxidation-reduction process
SB45_RS02545	COG0814	amino acid
SB45_RS02550	COG1473	amidohydrolase
SB45_RS02555	COG2207	Transcriptional regulator
SB45_RS02555	COG1917	Cupin 2, conserved barrel domain protein
SB45_RS02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB45_RS02570	COG0477	Major facilitator Superfamily
SB45_RS02590	COG0277	FAD linked oxidase domain protein
SB45_RS02620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SB45_RS02645	COG1064	alcohol dehydrogenase
SB45_RS02650	COG0789	Transcriptional regulator
SB45_RS02660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB45_RS02675	COG2814	Major facilitator Superfamily
SB45_RS02680	COG1309	transcriptional regulator
SB45_RS02685	COG5577	PFAM Coat F domain
SB45_RS02695	COG1063	alcohol dehydrogenase
SB45_RS02700	COG5577	PFAM Coat F domain
SB45_RS02715	COG4585	Histidine kinase
SB45_RS02720	COG2197	response regulator
SB45_RS02725	COG2409	Drug exporters of the RND superfamily
SB45_RS02730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SB45_RS02735	COG0488	(ABC) transporter
SB45_RS02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB45_RS02745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS02755	COG2814	Major facilitator Superfamily
SB45_RS02760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB45_RS02770	COG0730	response to heat
SB45_RS02775	COG0456	acetyltransferase
SB45_RS02780	COG0789	Transcriptional regulator
SB45_RS02780	COG4978	Transcriptional regulator
SB45_RS02785	COG0697	spore germination
SB45_RS02795	COG2226	methyltransferase
SB45_RS02800	COG0473	3-isopropylmalate dehydrogenase activity
SB45_RS02805	COG1802	Transcriptional regulator
SB45_RS02810	COG1819	glycosyl
SB45_RS02825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB45_RS02830	COG1388	LysM domain
SB45_RS02835	COG2814	Major facilitator Superfamily
SB45_RS02840	COG2188	Transcriptional regulator
SB45_RS02845	COG2186	Transcriptional regulator
SB45_RS02850	COG2807	transmembrane transport
SB45_RS02855	COG2076	Multidrug Resistance protein
SB45_RS02860	COG2076	Multidrug Resistance protein
SB45_RS02865	COG1309	transcriptional regulator
SB45_RS02870	COG0531	amino acid
SB45_RS02880	COG3832	glyoxalase III activity
SB45_RS02885	COG0604	alcohol dehydrogenase
SB45_RS02890	COG2814	Major facilitator Superfamily
SB45_RS02925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SB45_RS02930	COG0802	atpase or kinase
SB45_RS02935	COG1214	PFAM Peptidase M22, glycoprotease
SB45_RS02940	COG0456	acetyltransferase
SB45_RS02945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SB45_RS02950	COG0488	(ABC) transporter
SB45_RS02965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB45_RS02970	COG0805	protein transport
SB45_RS02980	COG1266	CAAX protease self-immunity
SB45_RS02995	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS03010	COG0457	Tetratricopeptide repeat
SB45_RS03015	COG1063	alcohol dehydrogenase
SB45_RS03020	COG2211	Major facilitator Superfamily
SB45_RS03025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB45_RS03035	COG1842	Phage shock protein A
SB45_RS03040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB45_RS03045	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SB45_RS03050	COG4260	virion core protein, lumpy skin disease virus
SB45_RS03055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SB45_RS03055	COG2755	lipolytic protein G-D-S-L family
SB45_RS03065	COG1595	DNA-templated transcription, initiation
SB45_RS03070	COG1063	alcohol dehydrogenase
SB45_RS03075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SB45_RS03080	COG0823	Involved in the tonB-independent uptake of proteins
SB45_RS03095	COG2132	Multicopper oxidase
SB45_RS03100	COG1113	amino acid transport
SB45_RS03105	COG0714	Associated with various cellular activities
SB45_RS03110	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
SB45_RS03115	COG1305	Transglutaminase-like
SB45_RS03135	COG2252	PERMEase
SB45_RS03140	COG3064	Membrane
SB45_RS03155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SB45_RS03160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SB45_RS03165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SB45_RS03170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SB45_RS03175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB45_RS03190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SB45_RS03200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SB45_RS03205	COG0138	bifunctional purine biosynthesis protein purh
SB45_RS03210	COG0151	Belongs to the GarS family
SB45_RS03220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SB45_RS03225	COG1470	cell adhesion involved in biofilm formation
SB45_RS03230	COG4496	protein, YerC YecD
SB45_RS03235	COG0069	glutamate synthase activity
SB45_RS03250	COG0210	DNA helicase
SB45_RS03260	COG4851	CamS sex pheromone cAM373 precursor
SB45_RS03265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB45_RS03270	COG1285	pathogenesis
SB45_RS03275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB45_RS03295	COG1309	transcriptional regulator
SB45_RS03300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SB45_RS03305	COG1597	lipid kinase activity
SB45_RS03310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB45_RS03320	COG1131	(ABC) transporter
SB45_RS03345	COG5444	nuclease activity
SB45_RS03380	COG3546	catalase activity
SB45_RS03385	COG0454	-acetyltransferase
SB45_RS03395	COG2323	membrane
SB45_RS03400	COG2329	Antibiotic biosynthesis monooxygenase
SB45_RS03405	COG0346	lactoylglutathione lyase activity
SB45_RS03410	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS03415	COG0196	riboflavin kinase activity
SB45_RS03420	COG0670	Belongs to the BI1 family
SB45_RS03435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB45_RS03435	COG2124	cytochrome p450
SB45_RS03445	COG1368	sulfuric ester hydrolase activity
SB45_RS03450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SB45_RS03455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS03460	COG1442	glycosyl transferase family 8
SB45_RS03465	COG1216	Glycosyl transferase, family 2
SB45_RS03470	COG1442	glycosyl transferase family 8
SB45_RS03475	COG2223	nitrite transmembrane transporter activity
SB45_RS03480	COG0531	amino acid
SB45_RS03485	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS03490	COG0840	transmembrane signaling receptor activity
SB45_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS03500	COG0463	Glycosyl transferase, family 2
SB45_RS03500	COG0457	Tetratricopeptide repeat
SB45_RS03505	COG0488	(ABC) transporter
SB45_RS03510	COG0789	Transcriptional regulator
SB45_RS03515	COG2814	Major facilitator Superfamily
SB45_RS03520	COG0488	(ABC) transporter
SB45_RS03525	COG0513	Belongs to the DEAD box helicase family
SB45_RS03535	COG2130	NADP-dependent
SB45_RS03550	COG3866	Pectate lyase
SB45_RS03555	COG0471	metal ion transport
SB45_RS03575	COG0745	RESPONSE REGULATOR receiver
SB45_RS03575	COG2972	Histidine kinase
SB45_RS03580	COG3279	Response regulator of the LytR AlgR family
SB45_RS03590	COG3764	Sortase (surface protein transpeptidase)
SB45_RS03595	COG3290	protein histidine kinase activity
SB45_RS03600	COG4565	transcriptional regulatory protein
SB45_RS03605	COG3181	Tripartite tricarboxylate transporter family receptor
SB45_RS03610	COG2851	Citrate transporter
SB45_RS03615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS03620	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SB45_RS03630	COG2258	MOSC domain
SB45_RS03640	COG0024	Methionine aminopeptidase
SB45_RS03645	COG1263	PTS System
SB45_RS03645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS03655	COG1368	sulfuric ester hydrolase activity
SB45_RS03665	COG0071	Belongs to the small heat shock protein (HSP20) family
SB45_RS03680	COG1263	PTS System
SB45_RS03680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS03685	COG0366	Alpha amylase catalytic
SB45_RS03690	COG2188	Transcriptional regulator
SB45_RS03695	COG0778	Nitroreductase
SB45_RS03710	COG0737	Belongs to the 5'-nucleotidase family
SB45_RS03715	COG0693	protein deglycase activity
SB45_RS03720	COG1609	Transcriptional regulator
SB45_RS03735	COG2814	Major facilitator Superfamily
SB45_RS03745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SB45_RS03750	COG4980	gas vesicle protein
SB45_RS03755	COG1295	ribonuclease BN
SB45_RS03760	COG0477	Major facilitator Superfamily
SB45_RS03765	COG0387	Pfam Sodium calcium exchanger
SB45_RS03775	COG0668	transmembrane transport
SB45_RS03780	COG0535	radical SAM domain protein
SB45_RS03790	COG0726	polysaccharide deacetylase
SB45_RS03795	COG2084	Dehydrogenase
SB45_RS03805	COG0598	Magnesium transport protein CorA
SB45_RS03810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SB45_RS03815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB45_RS03825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB45_RS03830	COG4637	Psort location Cytoplasmic, score
SB45_RS03835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB45_RS03840	COG0022	dehydrogenase e1 component
SB45_RS03845	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB45_RS03850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB45_RS03855	COG3284	Transcriptional regulator
SB45_RS03865	COG1486	melibiose metabolic process
SB45_RS03870	COG1737	Transcriptional regulator
SB45_RS03875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS03875	COG1263	PTS System
SB45_RS03880	COG1132	(ABC) transporter
SB45_RS03885	COG1132	(ABC) transporter
SB45_RS03890	COG2259	Doxx family
SB45_RS03895	COG2514	catechol 2,3-dioxygenase activity
SB45_RS03905	COG1695	Transcriptional regulator
SB45_RS03910	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB45_RS03915	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SB45_RS03920	COG0574	Belongs to the PEP-utilizing enzyme family
SB45_RS03920	COG3848	Pyruvate phosphate dikinase
SB45_RS03925	COG2732	(Barnase) inhibitor
SB45_RS03930	COG2318	DinB family
SB45_RS03935	COG2814	Major facilitator Superfamily
SB45_RS03940	COG1846	Transcriptional regulator
SB45_RS03945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SB45_RS03945	COG0392	lysyltransferase activity
SB45_RS03950	COG0384	phenazine biosynthesis protein PhzF
SB45_RS03955	COG0778	Nitroreductase
SB45_RS03965	COG1090	epimerase
SB45_RS03980	COG2814	Major facilitator Superfamily
SB45_RS03990	COG3591	Belongs to the peptidase S1B family
SB45_RS04005	COG3103	Sh3 type 3 domain protein
SB45_RS04010	COG5658	integral membrane protein
SB45_RS04015	COG0596	Alpha beta hydrolase
SB45_RS04020	COG0463	Glycosyl transferase, family 2
SB45_RS04025	COG4485	Bacterial membrane protein, YfhO
SB45_RS04030	COG1988	membrane-bound metal-dependent
SB45_RS04035	COG1194	a g-specific adenine glycosylase
SB45_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS04065	COG1132	(ABC) transporter
SB45_RS04070	COG4129	membrane
SB45_RS04080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SB45_RS04085	COG0735	belongs to the Fur family
SB45_RS04200	COG0277	FAD linked oxidase domain protein
SB45_RS04210	COG0747	negative chemotaxis
SB45_RS04215	COG0601	transmembrane transport
SB45_RS04220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB45_RS04225	COG0444	Belongs to the ABC transporter superfamily
SB45_RS04230	COG4608	Belongs to the ABC transporter superfamily
SB45_RS04235	COG0753	catalase activity
SB45_RS04245	COG1116	anion transmembrane transporter activity
SB45_RS04250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB45_RS04255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB45_RS04275	COG1476	TRANSCRIPTIONal
SB45_RS04285	COG3382	B3 4 domain protein
SB45_RS04290	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SB45_RS04300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SB45_RS04305	COG0789	Transcriptional regulator
SB45_RS04310	COG1664	Polymer-forming cytoskeletal
SB45_RS04315	COG1664	Polymer-forming cytoskeletal
SB45_RS04320	COG2766	serine protein kinase
SB45_RS04330	COG1846	Transcriptional regulator
SB45_RS04335	COG1566	PFAM secretion protein HlyD family protein
SB45_RS04340	COG2814	Major facilitator Superfamily
SB45_RS04345	COG0655	NAD(P)H dehydrogenase (quinone) activity
SB45_RS04360	COG1725	Transcriptional regulator
SB45_RS04365	COG1131	(ABC) transporter
SB45_RS04370	COG1131	(ABC) transporter
SB45_RS04375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB45_RS04380	COG1278	Cold shock
SB45_RS04385	COG1464	Belongs to the NlpA lipoprotein family
SB45_RS04390	COG3706	GGDEF domain
SB45_RS04395	COG1823	symporter activity
SB45_RS04415	COG5577	PFAM Coat F domain
SB45_RS04420	COG0737	Belongs to the 5'-nucleotidase family
SB45_RS04420	COG4085	toxin activity
SB45_RS04420	COG1525	nuclease
SB45_RS04425	COG3764	Sortase (surface protein transpeptidase)
SB45_RS04430	COG0564	pseudouridine synthase activity
SB45_RS04440	COG0517	IMP dehydrogenase activity
SB45_RS04445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB45_RS04450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB45_RS04450	COG3153	acetyltransferase
SB45_RS04455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB45_RS04460	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB45_RS04465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SB45_RS04475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SB45_RS04480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB45_RS04495	COG0431	NADPH-dependent FMN reductase
SB45_RS04510	COG0791	NLP P60 protein
SB45_RS04510	COG1388	LysM domain
SB45_RS04515	COG1959	2 iron, 2 sulfur cluster binding
SB45_RS04520	COG0668	transmembrane transport
SB45_RS04525	COG2719	SpoVR family
SB45_RS04530	COG1785	Belongs to the alkaline phosphatase family
SB45_RS04535	COG1388	LysM domain
SB45_RS04535	COG0791	NLP P60 protein
SB45_RS04540	COG0583	DNA-binding transcription factor activity
SB45_RS04545	COG0372	Belongs to the citrate synthase family
SB45_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS04555	COG0531	amino acid
SB45_RS04560	COG0733	neurotransmitter:sodium symporter activity
SB45_RS04575	COG1595	DNA-templated transcription, initiation
SB45_RS04580	COG0204	Acyl-transferase
SB45_RS04585	COG1253	flavin adenine dinucleotide binding
SB45_RS04590	COG0789	Transcriptional regulator
SB45_RS04595	COG0436	Aminotransferase
SB45_RS04600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB45_RS04605	COG1253	flavin adenine dinucleotide binding
SB45_RS04610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SB45_RS04615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SB45_RS04620	COG0584	glycerophosphoryl diester phosphodiesterase
SB45_RS04625	COG0668	transmembrane transport
SB45_RS04630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SB45_RS04635	COG0726	polysaccharide deacetylase
SB45_RS04640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB45_RS04645	COG3226	Transcriptional regulator
SB45_RS04655	COG0589	response to stress
SB45_RS04660	COG1132	(ABC) transporter
SB45_RS04665	COG1132	(ABC) transporter
SB45_RS04670	COG0702	epimerase
SB45_RS04685	COG0189	ligase activity
SB45_RS04690	COG0189	ligase activity
SB45_RS04705	COG4335	DNA alkylation repair
SB45_RS04710	COG0561	phosphatase activity
SB45_RS04715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB45_RS04725	COG0475	glutathione-regulated potassium exporter activity
SB45_RS04730	COG0490	domain, Protein
SB45_RS04740	COG1024	Enoyl-CoA hydratase
SB45_RS04750	COG4152	abc transporter atp-binding protein
SB45_RS04755	COG1668	transmembrane transport
SB45_RS04760	COG0420	3'-5' exonuclease activity
SB45_RS04765	COG4717	serine-type aminopeptidase activity
SB45_RS04780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB45_RS04820	COG4980	gas vesicle protein
SB45_RS04835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SB45_RS04840	COG0537	adenosine 5'-monophosphoramidase activity
SB45_RS04845	COG1131	(ABC) transporter
SB45_RS04850	COG4473	ABC transporter
SB45_RS04860	COG1473	amidohydrolase
SB45_RS04865	COG3069	C4-dicarboxylate transmembrane transporter activity
SB45_RS04870	COG2329	Antibiotic biosynthesis monooxygenase
SB45_RS04875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB45_RS04885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SB45_RS04890	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SB45_RS04895	COG1309	transcriptional regulator
SB45_RS04900	COG1511	domain protein
SB45_RS04905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB45_RS04915	COG1363	Peptidase, m42
SB45_RS04920	COG1301	dicarboxylic acid transport
SB45_RS04925	COG1234	tRNA 3'-trailer cleavage
SB45_RS04930	COG0095	Lipoate-protein ligase
SB45_RS04935	COG0702	epimerase
SB45_RS04940	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS04950	COG0501	Belongs to the peptidase M48B family
SB45_RS04955	COG1404	Belongs to the peptidase S8 family
SB45_RS04970	COG0406	alpha-ribazole phosphatase activity
SB45_RS04975	COG0183	Belongs to the thiolase family
SB45_RS04980	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS04985	COG1268	BioY protein
SB45_RS04990	COG0840	transmembrane signaling receptor activity
SB45_RS04995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB45_RS04995	COG0723	plastoquinol--plastocyanin reductase activity
SB45_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS05010	COG4903	ComK protein
SB45_RS05020	COG5646	InterPro IPR014922
SB45_RS05040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB45_RS05055	COG0398	Pfam SNARE associated Golgi protein
SB45_RS05060	COG0681	Belongs to the peptidase S26 family
SB45_RS05065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SB45_RS05070	COG1846	Transcriptional regulator
SB45_RS05075	COG3180	Ammonia monooxygenase
SB45_RS05080	COG2814	Major facilitator Superfamily
SB45_RS05090	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SB45_RS05095	COG2323	membrane
SB45_RS05110	COG0420	3'-5' exonuclease activity
SB45_RS05115	COG0419	ATPase involved in DNA repair
SB45_RS05120	COG1403	HNH endonuclease
SB45_RS05160	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB45_RS05180	COG0367	asparagine synthase
SB45_RS05185	COG1562	ergosterol biosynthetic process
SB45_RS05190	COG0534	Mate efflux family protein
SB45_RS05195	COG1917	Cupin 2, conserved barrel domain protein
SB45_RS05195	COG2207	Transcriptional regulator
SB45_RS05200	COG1609	Transcriptional regulator
SB45_RS05205	COG0673	inositol 2-dehydrogenase activity
SB45_RS05210	COG2318	DinB family
SB45_RS05215	COG1357	PFAM Pentapeptide repeats (8 copies)
SB45_RS05220	COG2153	protein acetylation
SB45_RS05225	COG0646	methionine synthase
SB45_RS05225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SB45_RS05235	COG2996	Protein conserved in bacteria
SB45_RS05240	COG1744	ABC transporter substrate-binding protein PnrA-like
SB45_RS05245	COG0840	transmembrane signaling receptor activity
SB45_RS05250	COG1307	EDD domain protein, DegV family
SB45_RS05255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS05270	COG0561	phosphatase activity
SB45_RS05275	COG1073	alpha beta
SB45_RS05280	COG2151	metal-sulfur cluster biosynthetic enzyme
SB45_RS05290	COG0277	FAD linked oxidase domain protein
SB45_RS05295	COG2271	Major facilitator Superfamily
SB45_RS05305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SB45_RS05315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB45_RS05320	COG0505	Belongs to the CarA family
SB45_RS05325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB45_RS05330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SB45_RS05350	COG2267	carboxylic ester hydrolase activity
SB45_RS05360	COG1744	ABC transporter substrate-binding protein PnrA-like
SB45_RS05375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB45_RS05380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB45_RS05385	COG5504	Zn-dependent protease
SB45_RS05390	COG0444	Belongs to the ABC transporter superfamily
SB45_RS05395	COG4608	Belongs to the ABC transporter superfamily
SB45_RS05405	COG0601	transmembrane transport
SB45_RS05410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB45_RS05430	COG0180	Tryptophanyl-tRNA synthetase
SB45_RS05435	COG4166	transmembrane transport
SB45_RS05440	COG0601	transmembrane transport
SB45_RS05445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB45_RS05450	COG0444	Belongs to the ABC transporter superfamily
SB45_RS05455	COG4608	Belongs to the ABC transporter superfamily
SB45_RS05465	COG0456	acetyltransferase
SB45_RS05470	COG1393	Belongs to the ArsC family
SB45_RS05475	COG0861	Integral membrane protein TerC family
SB45_RS05480	COG4862	establishment of competence for transformation
SB45_RS05485	COG4469	Competence protein
SB45_RS05490	COG1164	Oligoendopeptidase f
SB45_RS05500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB45_RS05505	COG2346	COG2346, Truncated hemoglobins
SB45_RS05510	COG0741	lytic transglycosylase activity
SB45_RS05515	COG4116	CYTH
SB45_RS05525	COG2357	RelA SpoT domain protein
SB45_RS05530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SB45_RS05535	COG0564	pseudouridine synthase activity
SB45_RS05545	COG0569	domain protein
SB45_RS05545	COG0475	glutathione-regulated potassium exporter activity
SB45_RS05550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SB45_RS05555	COG0352	thiamine-phosphate diphosphorylase activity
SB45_RS05560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB45_RS05565	COG2104	thiamine diphosphate biosynthetic process
SB45_RS05575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB45_RS05580	COG0351	phosphomethylpyrimidine kinase
SB45_RS05585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SB45_RS05640	COG0210	DNA helicase
SB45_RS05660	COG1131	(ABC) transporter
SB45_RS05670	COG2153	protein acetylation
SB45_RS05680	COG2382	esterase
SB45_RS05685	COG0626	cystathionine gamma-synthase activity
SB45_RS05690	COG0626	cystathionine gamma-synthase activity
SB45_RS05705	COG5444	nuclease activity
SB45_RS05715	COG0346	lactoylglutathione lyase activity
SB45_RS05720	COG2367	Beta-lactamase
SB45_RS05725	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SB45_RS05735	COG1846	Transcriptional regulator
SB45_RS05745	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB45_RS05750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB45_RS05755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SB45_RS05760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS05760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS05765	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB45_RS05775	COG1349	DNA-binding transcription factor activity
SB45_RS05795	COG1285	pathogenesis
SB45_RS05800	COG2205	protein histidine kinase activity
SB45_RS05810	COG3383	formate dehydrogenase (NAD+) activity
SB45_RS05815	COG2427	Protein of unknown function (DUF1641)
SB45_RS05820	COG2124	cytochrome p450
SB45_RS05825	COG1819	glycosyl
SB45_RS05835	COG1587	Uroporphyrinogen-III synthase
SB45_RS05840	COG0390	transport system, permease component
SB45_RS05845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB45_RS05850	COG0697	spore germination
SB45_RS05855	COG4297	protein containing double-stranded beta helix domain
SB45_RS05865	COG1252	NADH dehydrogenase
SB45_RS05875	COG2211	Major facilitator Superfamily
SB45_RS05880	COG1609	Transcriptional regulator
SB45_RS05895	COG0745	RESPONSE REGULATOR receiver
SB45_RS05900	COG2770	Histidine kinase
SB45_RS05900	COG2205	protein histidine kinase activity
SB45_RS05920	COG4585	Histidine kinase
SB45_RS05925	COG2197	response regulator
SB45_RS05950	COG0730	response to heat
SB45_RS05955	COG2318	DinB family
SB45_RS05960	COG0457	Tetratricopeptide repeat
SB45_RS05970	COG5632	N-Acetylmuramoyl-L-alanine amidase
SB45_RS05970	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS05970	COG1388	LysM domain
SB45_RS05980	COG4195	phage-related replication protein
SB45_RS05985	COG2856	Zn peptidase
SB45_RS05990	COG1396	sequence-specific DNA binding
SB45_RS06000	COG1522	sequence-specific DNA binding
SB45_RS06005	COG1484	DNA-dependent DNA replication
SB45_RS06020	COG1595	DNA-templated transcription, initiation
SB45_RS06025	COG3728	DNA packaging
SB45_RS06025	COG5484	DNA packaging
SB45_RS06030	COG1783	phage Terminase large subunit
SB45_RS06035	COG5518	Phage portal protein
SB45_RS06040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SB45_RS06045	COG4653	Phage capsid family
SB45_RS06090	COG3953	SLT domain
SB45_RS06090	COG5412	phage tail tape measure protein
SB45_RS06090	COG3953	SLT domain
SB45_RS06090	COG5412	phage tail tape measure protein
SB45_RS06090	COG3953	SLT domain
SB45_RS06090	COG5412	phage tail tape measure protein
SB45_RS06095	COG1652	LysM domain
SB45_RS06100	COG4193	domain, Protein
SB45_RS06110	COG3628	GPW Gp25 family protein
SB45_RS06115	COG3299	homolog of phage Mu protein gp47
SB45_RS06120	COG3778	Protein conserved in bacteria
SB45_RS06160	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS06160	COG5632	N-Acetylmuramoyl-L-alanine amidase
SB45_RS06175	COG0306	phosphate transporter
SB45_RS06180	COG1392	Phosphate transport regulator
SB45_RS06185	COG0531	amino acid
SB45_RS06190	COG0346	lactoylglutathione lyase activity
SB45_RS06195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SB45_RS06200	COG0463	Glycosyl transferase, family 2
SB45_RS06205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB45_RS06210	COG0477	Major facilitator Superfamily
SB45_RS06215	COG2362	D-Aminopeptidase
SB45_RS06220	COG0601	transmembrane transport
SB45_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB45_RS06230	COG0444	Belongs to the ABC transporter superfamily
SB45_RS06235	COG4166	transmembrane transport
SB45_RS06240	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB45_RS06245	COG4948	Mandelate Racemase Muconate Lactonizing
SB45_RS06250	COG0791	NLP P60 protein
SB45_RS06255	COG4608	Belongs to the ABC transporter superfamily
SB45_RS06260	COG2706	6-phosphogluconolactonase activity
SB45_RS06265	COG1834	amidinotransferase
SB45_RS06270	COG1607	acyl-coa hydrolase
SB45_RS06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB45_RS06280	COG2076	Multidrug Resistance protein
SB45_RS06285	COG2076	Multidrug Resistance protein
SB45_RS06290	COG0788	formyltetrahydrofolate deformylase activity
SB45_RS06295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB45_RS06305	COG1764	response to oxidative stress
SB45_RS06310	COG1846	Transcriptional regulator
SB45_RS06315	COG1764	response to oxidative stress
SB45_RS06330	COG0463	Glycosyl transferase, family 2
SB45_RS06330	COG0457	Tetratricopeptide repeat
SB45_RS06340	COG2814	Major facilitator Superfamily
SB45_RS06345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB45_RS06355	COG1404	Belongs to the peptidase S8 family
SB45_RS06360	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS06365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB45_RS06370	COG1122	ATPase activity
SB45_RS06375	COG4721	ABC-type cobalt transport system, permease component
SB45_RS06380	COG1388	LysM domain
SB45_RS06380	COG3858	chitin binding
SB45_RS06385	COG2239	Acts as a magnesium transporter
SB45_RS06390	COG0789	Transcriptional regulator
SB45_RS06400	COG1846	Transcriptional regulator
SB45_RS06405	COG0726	polysaccharide deacetylase
SB45_RS06410	COG3285	dna ligase
SB45_RS06410	COG1793	dna ligase
SB45_RS06415	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SB45_RS06425	COG0586	Pfam SNARE associated Golgi protein
SB45_RS06430	COG0861	Integral membrane protein TerC family
SB45_RS06435	COG1191	sigma factor activity
SB45_RS06460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SB45_RS06465	COG2323	membrane
SB45_RS06470	COG3594	Acyltransferase
SB45_RS06475	COG5002	protein histidine kinase activity
SB45_RS06480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB45_RS06495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB45_RS06500	COG0436	Aminotransferase
SB45_RS06530	COG3852	Histidine kinase
SB45_RS06535	COG1846	Transcriptional regulator
SB45_RS06540	COG1360	Flagellar Motor Protein
SB45_RS06545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB45_RS06550	COG0542	response to heat
SB45_RS06560	COG3949	Membrane
SB45_RS06575	COG0720	synthase
SB45_RS06580	COG0602	queuosine metabolic process
SB45_RS06625	COG4873	Protein conserved in bacteria
SB45_RS06635	COG3773	Cell wall hydrolase
SB45_RS06640	COG2244	polysaccharide biosynthetic process
SB45_RS06645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS06650	COG2217	Heavy metal translocating P-type atpase
SB45_RS06655	COG0006	proline dipeptidase activity
SB45_RS06660	COG1609	Transcriptional regulator
SB45_RS06665	COG3711	transcriptional antiterminator
SB45_RS06670	COG2190	(PTS) system
SB45_RS06670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS06670	COG1263	PTS System
SB45_RS06675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS06680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SB45_RS06690	COG1533	DNA photolyase activity
SB45_RS06695	COG0840	transmembrane signaling receptor activity
SB45_RS06700	COG2084	Dehydrogenase
SB45_RS06710	COG0347	Belongs to the P(II) protein family
SB45_RS06715	COG2340	Cysteine-rich secretory protein family
SB45_RS06720	COG0768	penicillin binding
SB45_RS06725	COG4191	Histidine kinase
SB45_RS06730	COG0436	Aminotransferase
SB45_RS06735	COG0835	chemotaxis
SB45_RS06735	COG0784	Response regulator, receiver
SB45_RS06745	COG2814	Major facilitator Superfamily
SB45_RS06750	COG1376	ErfK ybiS ycfS ynhG family protein
SB45_RS06755	COG1408	metallophosphoesterase
SB45_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS06770	COG2200	EAL domain
SB45_RS06775	COG4703	Protein of unknown function (DUF1797)
SB45_RS06780	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SB45_RS06790	COG0517	IMP dehydrogenase activity
SB45_RS06795	COG0583	DNA-binding transcription factor activity
SB45_RS06800	COG0716	FMN binding
SB45_RS06810	COG0716	FMN binding
SB45_RS06830	COG0668	transmembrane transport
SB45_RS06835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS06855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB45_RS06860	COG0303	'Molybdopterin
SB45_RS06865	COG1763	Mo-molybdopterin cofactor biosynthetic process
SB45_RS06870	COG0314	molybdopterin synthase activity
SB45_RS06875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SB45_RS06885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SB45_RS06890	COG1136	(ABC) transporter
SB45_RS06895	COG0577	efflux transmembrane transporter activity
SB45_RS06900	COG1349	DNA-binding transcription factor activity
SB45_RS06905	COG1105	Belongs to the carbohydrate kinase PfkB family
SB45_RS06910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB45_RS06910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS06910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB45_RS06915	COG0681	Belongs to the peptidase S26 family
SB45_RS06925	COG0488	(ABC) transporter
SB45_RS06930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB45_RS06935	COG2309	aminopeptidase activity
SB45_RS06940	COG1077	Cell shape determining protein MreB Mrl
SB45_RS06950	COG2002	toxin-antitoxin pair type II binding
SB45_RS06955	COG3852	Histidine kinase
SB45_RS06960	COG2105	PFAM AIG2 family protein
SB45_RS06960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SB45_RS06965	COG0569	domain protein
SB45_RS06975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB45_RS06985	COG0561	phosphatase activity
SB45_RS06990	COG0242	peptide deformylase activity
SB45_RS07000	COG0497	DNA recombination
SB45_RS07010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS07010	COG4221	oxidoreductase activity
SB45_RS07010	COG3321	synthase
SB45_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS07015	COG4221	oxidoreductase activity
SB45_RS07015	COG3321	synthase
SB45_RS07015	COG0300	oxidoreductase activity
SB45_RS07015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS07020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS07020	COG3321	synthase
SB45_RS07020	COG4221	oxidoreductase activity
SB45_RS07025	COG0300	oxidoreductase activity
SB45_RS07025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS07025	COG3321	synthase
SB45_RS07025	COG4221	oxidoreductase activity
SB45_RS07030	COG4221	oxidoreductase activity
SB45_RS07030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS07030	COG3321	synthase
SB45_RS07030	COG0300	oxidoreductase activity
SB45_RS07035	COG4221	oxidoreductase activity
SB45_RS07035	COG3321	synthase
SB45_RS07035	COG0300	oxidoreductase activity
SB45_RS07035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS07040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS07040	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS07040	COG3321	synthase
SB45_RS07040	COG4221	oxidoreductase activity
SB45_RS07045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB45_RS07050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB45_RS07055	COG0022	dehydrogenase e1 component
SB45_RS07060	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB45_RS07065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB45_RS07070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS07080	COG1982	Orn Lys Arg decarboxylase major
SB45_RS07100	COG0483	inositol monophosphate 1-phosphatase activity
SB45_RS07110	COG3227	Zinc metalloprotease (Elastase)
SB45_RS07125	COG1595	DNA-templated transcription, initiation
SB45_RS07145	COG1217	gtp-binding protein TYPA
SB45_RS07155	COG4896	Protein conserved in bacteria
SB45_RS07165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SB45_RS07170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB45_RS07175	COG2066	Belongs to the glutaminase family
SB45_RS07185	COG0772	Belongs to the SEDS family
SB45_RS07190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SB45_RS07205	COG2010	Cytochrome c
SB45_RS07205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB45_RS07210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SB45_RS07215	COG1845	cytochrome c oxidase, subunit III
SB45_RS07220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB45_RS07225	COG3336	cytochrome c oxidase
SB45_RS07235	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SB45_RS07240	COG2340	Cysteine-rich secretory protein family
SB45_RS07255	COG3679	Belongs to the UPF0342 family
SB45_RS07270	COG0742	ribosomal rna small subunit methyltransferase
SB45_RS07280	COG3314	Sporulation integral membrane protein YlbJ
SB45_RS07285	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB45_RS07290	COG3480	Lon protease (S16) C-terminal proteolytic domain
SB45_RS07300	COG1399	metal-binding, possibly nucleic acid-binding protein
SB45_RS07315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB45_RS07335	COG4839	cell division protein FtsL
SB45_RS07340	COG0768	penicillin binding
SB45_RS07345	COG0768	penicillin binding
SB45_RS07365	COG0772	Belongs to the SEDS family
SB45_RS07380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SB45_RS07385	COG0849	cell division
SB45_RS07390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SB45_RS07395	COG1404	Belongs to the peptidase S8 family
SB45_RS07395	COG4412	M6 family metalloprotease domain protein
SB45_RS07405	COG1191	sigma factor activity
SB45_RS07410	COG1191	sigma factor activity
SB45_RS07415	COG1119	ATPase activity
SB45_RS07420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB45_RS07425	COG1873	PFAM PRC-barrel domain
SB45_RS07430	COG1496	oxidoreductase activity
SB45_RS07435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SB45_RS07445	COG0762	integral membrane protein
SB45_RS07450	COG2302	S4 RNA-binding domain
SB45_RS07455	COG3599	regulation of cell shape
SB45_RS07465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SB45_RS07470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB45_RS07480	COG0564	pseudouridine synthase activity
SB45_RS07490	COG2233	PERMEase
SB45_RS07500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SB45_RS07505	COG0505	Belongs to the CarA family
SB45_RS07510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB45_RS07525	COG0284	orotidine-5'-phosphate decarboxylase activity
SB45_RS07530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SB45_RS07540	COG0306	phosphate transporter
SB45_RS07555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SB45_RS07560	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SB45_RS07565	COG1648	precorrin-2 dehydrogenase activity
SB45_RS07575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SB45_RS07580	COG1561	YicC-like family, N-terminal region
SB45_RS07590	COG0194	GDP metabolic process
SB45_RS07600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB45_RS07605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB45_RS07610	COG0242	peptide deformylase activity
SB45_RS07620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB45_RS07620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SB45_RS07630	COG0631	protein serine/threonine phosphatase activity
SB45_RS07635	COG0515	serine threonine protein kinase
SB45_RS07635	COG2815	serine threonine protein kinase
SB45_RS07645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB45_RS07650	COG1564	THIamine pyrophosphokinase
SB45_RS07665	COG1302	Protein conserved in bacteria
SB45_RS07670	COG1461	Dihydroxyacetone kinase
SB45_RS07675	COG1760	l-serine dehydratase
SB45_RS07680	COG1760	l-serine dehydratase
SB45_RS07685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SB45_RS07700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB45_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS07720	COG1196	nuclear chromosome segregation
SB45_RS07725	COG0552	protein localization to endoplasmic reticulum
SB45_RS07740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SB45_RS07750	COG1837	Belongs to the UPF0109 family
SB45_RS07775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB45_RS07790	COG2257	FlhB HrpN YscU SpaS Family
SB45_RS07800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SB45_RS07805	COG0758	DNA mediated transformation
SB45_RS07810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB45_RS07820	COG4974	Belongs to the 'phage' integrase family
SB45_RS07840	COG1815	bacterial-type flagellum-dependent cell motility
SB45_RS07845	COG1558	bacterial-type flagellum-dependent cell motility
SB45_RS07850	COG1677	Flagellar hook-basal body complex protein FliE
SB45_RS07855	COG1766	The M ring may be actively involved in energy transduction
SB45_RS07860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB45_RS07865	COG1317	bacterial-type flagellum organization
SB45_RS07870	COG1157	protein secretion by the type III secretion system
SB45_RS07875	COG2882	bacterial-type flagellum organization
SB45_RS07880	COG3334	PFAM MgtE intracellular
SB45_RS07885	COG3144	bacterial-type flagellum assembly
SB45_RS07890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SB45_RS07895	COG4786	Flagellar basal body rod
SB45_RS07900	COG1582	Flagellar protein (FlbD)
SB45_RS07905	COG1580	Controls the rotational direction of flagella during chemotaxis
SB45_RS07910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB45_RS07915	COG1776	CheC inhibitor of MCP methylation
SB45_RS07915	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB45_RS07920	COG2201	protein-glutamate methylesterase activity
SB45_RS07925	COG3190	flagellar
SB45_RS07930	COG1338	Plays a role in the flagellum-specific transport system
SB45_RS07935	COG1987	bacterial-type flagellum assembly
SB45_RS07940	COG1684	flagellar biosynthetic protein fliR
SB45_RS07945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB45_RS07950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB45_RS07955	COG1419	protein localization to endoplasmic reticulum
SB45_RS07960	COG0455	bacterial-type flagellum organization
SB45_RS07965	COG2201	protein-glutamate methylesterase activity
SB45_RS07970	COG2198	Histidine kinase
SB45_RS07970	COG0643	Histidine kinase
SB45_RS07975	COG0835	chemotaxis
SB45_RS07980	COG1776	CheC inhibitor of MCP methylation
SB45_RS07990	COG1191	sigma factor activity
SB45_RS08020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SB45_RS08025	COG4589	Belongs to the CDS family
SB45_RS08035	COG0750	zinc metalloprotease
SB45_RS08045	COG2176	DNA-directed DNA polymerase activity
SB45_RS08055	COG0195	Participates in both transcription termination and antitermination
SB45_RS08060	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SB45_RS08065	COG1358	cellular component organization or biogenesis
SB45_RS08075	COG1550	Protein conserved in bacteria
SB45_RS08090	COG0196	riboflavin kinase activity
SB45_RS08105	COG0726	polysaccharide deacetylase
SB45_RS08110	COG0612	Peptidase, M16
SB45_RS08115	COG1873	PFAM PRC-barrel domain
SB45_RS08120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB45_RS08125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB45_RS08130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SB45_RS08135	COG0527	aspartate kinase activity
SB45_RS08145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB45_RS08150	COG0740	serine-type endopeptidase activity
SB45_RS08160	COG4980	gas vesicle protein
SB45_RS08160	COG1674	ftsk spoiiie
SB45_RS08165	COG2188	Transcriptional regulator
SB45_RS08170	COG2814	Major facilitator Superfamily
SB45_RS08175	COG1846	Transcriptional regulator
SB45_RS08180	COG2409	Drug exporters of the RND superfamily
SB45_RS08180	COG1033	growth of symbiont in host cell
SB45_RS08185	COG0612	Peptidase, M16
SB45_RS08190	COG0612	Peptidase, M16
SB45_RS08195	COG0300	oxidoreductase activity
SB45_RS08210	COG1426	Protein conserved in bacteria
SB45_RS08215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SB45_RS08230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB45_RS08240	COG1692	metallophosphoesterase
SB45_RS08245	COG2359	stage V sporulation protein S
SB45_RS08265	COG4550	Control of competence regulator ComK, YlbF/YmcA
SB45_RS08285	COG0582	viral genome integration into host DNA
SB45_RS08295	COG1396	sequence-specific DNA binding
SB45_RS08380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SB45_RS08385	COG0582	viral genome integration into host DNA
SB45_RS08480	COG5280	Phage tail tape measure protein TP901
SB45_RS08480	COG3953	SLT domain
SB45_RS08490	COG1705	Flagellar rod assembly protein muramidase FlgJ
SB45_RS08495	COG5434	Belongs to the glycosyl hydrolase 28 family
SB45_RS08515	COG4824	toxin secretion phage lysis holin
SB45_RS08520	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS08520	COG5632	N-Acetylmuramoyl-L-alanine amidase
SB45_RS08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS08570	COG3425	synthase
SB45_RS08575	COG1024	Enoyl-CoA hydratase
SB45_RS08580	COG1024	Enoyl-CoA hydratase
SB45_RS08585	COG3321	synthase
SB45_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS08585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS08585	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS08585	COG0300	oxidoreductase activity
SB45_RS08590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS08590	COG4221	oxidoreductase activity
SB45_RS08590	COG0300	oxidoreductase activity
SB45_RS08590	COG3321	synthase
SB45_RS08595	COG3321	synthase
SB45_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS08595	COG3321	synthase
SB45_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS08595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS08595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS08595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS08595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS08600	COG3321	synthase
SB45_RS08600	COG4221	oxidoreductase activity
SB45_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS08600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS08605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS08605	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SB45_RS08605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SB45_RS08605	COG3321	synthase
SB45_RS08610	COG2124	cytochrome p450
SB45_RS08615	COG3209	COG3209 Rhs family protein
SB45_RS08620	COG3619	membrane
SB45_RS08630	COG1404	Belongs to the peptidase S8 family
SB45_RS08640	COG4195	phage-related replication protein
SB45_RS08645	COG1764	response to oxidative stress
SB45_RS08655	COG2076	Multidrug Resistance protein
SB45_RS08695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB45_RS08700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB45_RS08705	COG4112	unkown
SB45_RS08720	COG0464	growth
SB45_RS08725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SB45_RS08730	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SB45_RS08735	COG0789	Transcriptional regulator
SB45_RS08740	COG0174	glutamine synthetase
SB45_RS08750	COG2211	Major facilitator Superfamily
SB45_RS08755	COG3507	Belongs to the glycosyl hydrolase 43 family
SB45_RS08770	COG1070	Carbohydrate kinase
SB45_RS08775	COG0574	Belongs to the PEP-utilizing enzyme family
SB45_RS08775	COG3848	Pyruvate phosphate dikinase
SB45_RS08795	COG1064	alcohol dehydrogenase
SB45_RS08825	COG3397	chitin binding
SB45_RS08840	COG5434	Belongs to the glycosyl hydrolase 28 family
SB45_RS08845	COG0756	dUTP diphosphatase activity
SB45_RS08850	COG4195	phage-related replication protein
SB45_RS08880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SB45_RS08890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SB45_RS08910	COG0785	Cytochrome C biogenesis protein
SB45_RS08915	COG2201	protein-glutamate methylesterase activity
SB45_RS08920	COG4846	Membrane protein involved in cytochrome C biogenesis
SB45_RS08930	COG0071	Belongs to the small heat shock protein (HSP20) family
SB45_RS08945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SB45_RS08950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS08970	COG0824	Thioesterase
SB45_RS08980	COG4841	protein insertion into membrane
SB45_RS08990	COG1832	CoA-binding protein
SB45_RS08995	COG0187	DNA topoisomerase II activity
SB45_RS09000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB45_RS09010	COG1115	amino acid carrier protein
SB45_RS09020	COG1063	alcohol dehydrogenase
SB45_RS09025	COG0800	Aldolase
SB45_RS09030	COG1312	Catalyzes the dehydration of D-mannonate
SB45_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS09040	COG1609	Transcriptional regulator
SB45_RS09045	COG2271	Major facilitator Superfamily
SB45_RS09095	COG2205	protein histidine kinase activity
SB45_RS09100	COG0745	RESPONSE REGULATOR receiver
SB45_RS09110	COG3507	Belongs to the glycosyl hydrolase 43 family
SB45_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS09140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SB45_RS09145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SB45_RS09150	COG2610	gluconate transmembrane transporter activity
SB45_RS09155	COG2124	cytochrome p450
SB45_RS09175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB45_RS09185	COG2246	polysaccharide biosynthetic process
SB45_RS09190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB45_RS09195	COG0586	Pfam SNARE associated Golgi protein
SB45_RS09200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB45_RS09205	COG1024	Enoyl-CoA hydratase
SB45_RS09210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB45_RS09215	COG0511	ligase activity, forming carbon-carbon bonds
SB45_RS09220	COG0439	Biotin carboxylase
SB45_RS09225	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS09230	COG1960	acyl-CoA dehydrogenase activity
SB45_RS09235	COG1649	PFAM Uncharacterised BCR, COG1649
SB45_RS09245	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SB45_RS09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS09255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS09275	COG2027	D-alanyl-D-alanine carboxypeptidase
SB45_RS09280	COG2017	converts alpha-aldose to the beta-anomer
SB45_RS09285	COG0534	Mate efflux family protein
SB45_RS09300	COG0582	viral genome integration into host DNA
SB45_RS09305	COG0166	Belongs to the GPI family
SB45_RS09310	COG0405	Gamma-glutamyltransferase
SB45_RS09315	COG2814	Major facilitator Superfamily
SB45_RS09320	COG0640	Transcriptional regulator
SB45_RS09335	COG0604	alcohol dehydrogenase
SB45_RS09340	COG0493	'glutamate synthase
SB45_RS09345	COG0069	glutamate synthase activity
SB45_RS09345	COG0070	glutamate synthase
SB45_RS09345	COG0067	glutamate synthase
SB45_RS09350	COG0583	DNA-binding transcription factor activity
SB45_RS09355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB45_RS09370	COG0300	oxidoreductase activity
SB45_RS09375	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SB45_RS09385	COG2814	Major facilitator Superfamily
SB45_RS09390	COG1070	Carbohydrate kinase
SB45_RS09395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB45_RS09400	COG0243	molybdopterin cofactor binding
SB45_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS09425	COG1733	regulation of RNA biosynthetic process
SB45_RS09430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB45_RS09435	COG2207	Transcriptional regulator
SB45_RS09435	COG0662	Cupin 2, conserved barrel domain protein
SB45_RS09440	COG1309	transcriptional regulator
SB45_RS09445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS09455	COG0640	Transcriptional regulator
SB45_RS09460	COG0741	lytic transglycosylase activity
SB45_RS09465	COG2322	membrane
SB45_RS09480	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB45_RS09490	COG1388	LysM domain
SB45_RS09490	COG3584	3D domain protein
SB45_RS09495	COG0514	ATP-dependent DNA helicase (RecQ)
SB45_RS09500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SB45_RS09505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB45_RS09520	COG0071	Belongs to the small heat shock protein (HSP20) family
SB45_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS09550	COG1657	PFAM Prenyltransferase squalene oxidase
SB45_RS09555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB45_RS09560	COG0733	neurotransmitter:sodium symporter activity
SB45_RS09565	COG0385	Bile acid
SB45_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB45_RS09585	COG4548	von Willebrand factor, type A
SB45_RS09590	COG0714	Associated with various cellular activities
SB45_RS09595	COG2032	superoxide dismutase activity
SB45_RS09600	COG1388	LysM domain
SB45_RS09600	COG0791	NLP P60 protein
SB45_RS09605	COG1819	glycosyl
SB45_RS09610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB45_RS09615	COG0534	Mate efflux family protein
SB45_RS09620	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS09625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB45_RS09630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB45_RS09640	COG2962	Rard protein
SB45_RS09655	COG1942	4-Oxalocrotonate Tautomerase
SB45_RS09665	COG1733	regulation of RNA biosynthetic process
SB45_RS09670	COG0778	Nitroreductase
SB45_RS09675	COG0400	carboxylic ester hydrolase activity
SB45_RS09680	COG0346	lactoylglutathione lyase activity
SB45_RS09690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB45_RS09700	COG2723	6-phospho-beta-galactosidase activity
SB45_RS09705	COG2188	Transcriptional regulator
SB45_RS09710	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS09710	COG0793	Belongs to the peptidase S41A family
SB45_RS09715	COG2226	methyltransferase
SB45_RS09725	COG1876	peptidase activity
SB45_RS09740	COG0671	phosphoesterase, PA-phosphatase related
SB45_RS09770	COG1509	lysine 2,3-aminomutase activity
SB45_RS09775	COG0456	acetyltransferase
SB45_RS09780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB45_RS09785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SB45_RS09790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SB45_RS09795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB45_RS09800	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SB45_RS09810	COG0456	acetyltransferase
SB45_RS09815	COG0463	Glycosyl transferase, family 2
SB45_RS09830	COG4641	Protein conserved in bacteria
SB45_RS09840	COG1086	Polysaccharide biosynthesis protein
SB45_RS09885	COG1388	LysM domain
SB45_RS09890	COG0457	Tetratricopeptide repeat
SB45_RS09900	COG3391	amine dehydrogenase activity
SB45_RS09935	COG5444	nuclease activity
SB45_RS09940	COG4282	regulation of fungal-type cell wall biogenesis
SB45_RS09950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SB45_RS09970	COG1846	Transcriptional regulator
SB45_RS09975	COG4698	Protein conserved in bacteria
SB45_RS09980	COG2755	lipolytic protein G-D-S-L family
SB45_RS09985	COG1999	signal sequence binding
SB45_RS09995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SB45_RS10000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB45_RS10005	COG1272	protein, Hemolysin III
SB45_RS10010	COG0204	Acyl-transferase
SB45_RS10015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB45_RS10030	COG2136	Putative SAM-dependent methyltransferase
SB45_RS10030	COG2521	methyltransferase
SB45_RS10045	COG1413	lyase activity
SB45_RS10055	COG0386	Belongs to the glutathione peroxidase family
SB45_RS10065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB45_RS10070	COG1278	Cold shock
SB45_RS10090	COG0328	RNA-DNA hybrid ribonuclease activity
SB45_RS10095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SB45_RS10100	COG0328	RNA-DNA hybrid ribonuclease activity
SB45_RS10110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB45_RS10120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB45_RS10125	COG1755	Isoprenylcysteine carboxyl methyltransferase
SB45_RS10130	COG3424	synthase
SB45_RS10155	COG1335	isochorismatase
SB45_RS10165	COG2233	PERMEase
SB45_RS10175	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SB45_RS10180	COG1199	ATP-dependent helicase activity
SB45_RS10195	COG0116	Belongs to the methyltransferase superfamily
SB45_RS10210	COG3359	exonuclease
SB45_RS10215	COG1111	helicase
SB45_RS10215	COG1205	dead DEAH box helicase
SB45_RS10220	COG2190	(PTS) system
SB45_RS10225	COG0071	Belongs to the small heat shock protein (HSP20) family
SB45_RS10265	COG4499	WXG100 protein secretion system (Wss), protein YukC
SB45_RS10265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB45_RS10275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SB45_RS10280	COG3935	DnaD domain protein
SB45_RS10290	COG0436	Aminotransferase
SB45_RS10295	COG5353	protein conserved in bacteria
SB45_RS10300	COG1199	ATP-dependent helicase activity
SB45_RS10300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SB45_RS10330	COG0438	transferase activity, transferring glycosyl groups
SB45_RS10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB45_RS10350	COG1694	Mazg nucleotide pyrophosphohydrolase
SB45_RS10355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS10360	COG2140	Oxalate decarboxylase
SB45_RS10370	COG4347	Protein of unknown function (DUF1405)
SB45_RS10375	COG2010	Cytochrome c
SB45_RS10375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB45_RS10380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB45_RS10385	COG0723	plastoquinol--plastocyanin reductase activity
SB45_RS10400	COG0457	Tetratricopeptide repeat
SB45_RS10410	COG0287	Prephenate dehydrogenase
SB45_RS10445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SB45_RS10450	COG4401	Chorismate mutase type I
SB45_RS10465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB45_RS10470	COG0105	UTP biosynthetic process
SB45_RS10475	COG0142	geranyltranstransferase activity
SB45_RS10485	COG0142	geranyltranstransferase activity
SB45_RS10500	COG0776	regulation of translation
SB45_RS10505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB45_RS10540	COG0539	negative regulation of cytoplasmic translation
SB45_RS10550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SB45_RS10555	COG2959	enzyme of heme biosynthesis
SB45_RS10560	COG3773	Cell wall hydrolase
SB45_RS10560	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS10565	COG2339	peptidase activity
SB45_RS10570	COG0492	ferredoxin-NADP+ reductase activity
SB45_RS10575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB45_RS10580	COG4862	establishment of competence for transformation
SB45_RS10585	COG1408	metallophosphoesterase
SB45_RS10595	COG1388	LysM domain
SB45_RS10600	COG1266	CAAX protease self-immunity
SB45_RS10605	COG0514	ATP-dependent DNA helicase (RecQ)
SB45_RS10610	COG4955	Helix-turn-helix domain
SB45_RS10615	COG1141	Ferredoxin
SB45_RS10620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SB45_RS10625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB45_RS10635	COG1595	DNA-templated transcription, initiation
SB45_RS10640	COG5002	protein histidine kinase activity
SB45_RS10645	COG0745	RESPONSE REGULATOR receiver
SB45_RS10650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB45_RS10655	COG1333	cytochrome c biogenesis protein
SB45_RS10660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS10665	COG1187	pseudouridine synthase activity
SB45_RS10670	COG0700	Nucleoside recognition
SB45_RS10675	COG2715	membrane protein required for spore maturation
SB45_RS10680	COG1686	Belongs to the peptidase S11 family
SB45_RS10700	COG1547	Domain of unknown function (DUF309)
SB45_RS10705	COG0456	acetyltransferase
SB45_RS10720	COG0307	riboflavin synthase, alpha
SB45_RS10725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB45_RS10725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB45_RS10735	COG0681	Belongs to the peptidase S26 family
SB45_RS10745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SB45_RS10750	COG4086	secreted protein
SB45_RS10755	COG0019	diaminopimelate decarboxylase activity
SB45_RS10760	COG0697	spore germination
SB45_RS10775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB45_RS10795	COG1191	sigma factor activity
SB45_RS10805	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS10810	COG1686	Belongs to the peptidase S11 family
SB45_RS10815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SB45_RS10820	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SB45_RS10825	COG4974	Belongs to the 'phage' integrase family
SB45_RS10835	COG0735	belongs to the Fur family
SB45_RS10840	COG1300	Membrane
SB45_RS10855	COG0281	malic enzyme
SB45_RS10860	COG1757	Na H antiporter
SB45_RS10865	COG1027	Aspartate ammonia-lyase
SB45_RS10870	COG0252	asparaginase activity
SB45_RS10875	COG1396	sequence-specific DNA binding
SB45_RS10880	COG1379	DNA repair
SB45_RS10885	COG0494	nUDIX hydrolase
SB45_RS10895	COG0667	Aldo Keto reductase
SB45_RS10905	COG1073	alpha beta
SB45_RS10915	COG4918	Iron-sulphur cluster biosynthesis
SB45_RS10920	COG0456	acetyltransferase
SB45_RS10920	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SB45_RS10925	COG2329	Antibiotic biosynthesis monooxygenase
SB45_RS10930	COG0456	acetyltransferase
SB45_RS10935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB45_RS10950	COG0628	permease
SB45_RS10955	COG0346	lactoylglutathione lyase activity
SB45_RS10965	COG3048	D-serine ammonia-lyase activity
SB45_RS10970	COG0300	oxidoreductase activity
SB45_RS10975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS10980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB45_RS10985	COG1024	Enoyl-CoA hydratase
SB45_RS10990	COG3425	synthase
SB45_RS10995	COG2124	cytochrome p450
SB45_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS11000	COG3321	synthase
SB45_RS11000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS11005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS11005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11005	COG3321	synthase
SB45_RS11005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11010	COG0300	oxidoreductase activity
SB45_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11010	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS11010	COG3321	synthase
SB45_RS11010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11015	COG3321	synthase
SB45_RS11015	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS11015	COG0300	oxidoreductase activity
SB45_RS11020	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS11020	COG3321	synthase
SB45_RS11020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11025	COG3321	synthase
SB45_RS11025	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS11025	COG0300	oxidoreductase activity
SB45_RS11025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS11030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS11030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB45_RS11030	COG3321	synthase
SB45_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS11055	COG2070	2-Nitropropane dioxygenase
SB45_RS11055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB45_RS11060	COG0250	Participates in transcription elongation, termination and antitermination
SB45_RS11080	COG0596	Alpha beta hydrolase
SB45_RS11095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SB45_RS11100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SB45_RS11115	COG0706	membrane insertase activity
SB45_RS11120	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB45_RS11125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB45_RS11130	COG0346	lactoylglutathione lyase activity
SB45_RS11135	COG1376	ErfK ybiS ycfS ynhG family protein
SB45_RS11140	COG4129	membrane
SB45_RS11145	COG1126	abc transporter atp-binding protein
SB45_RS11150	COG0765	amino acid transport
SB45_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS11165	COG1597	lipid kinase activity
SB45_RS11170	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB45_RS11175	COG0022	dehydrogenase e1 component
SB45_RS11180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB45_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB45_RS11190	COG3426	butyrate kinase activity
SB45_RS11195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB45_RS11200	COG0280	phosphate acetyltransferase
SB45_RS11205	COG3829	transcription factor binding
SB45_RS11205	COG3290	protein histidine kinase activity
SB45_RS11215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SB45_RS11220	COG2079	MmgE PrpD family protein
SB45_RS11225	COG0372	Belongs to the citrate synthase family
SB45_RS11230	COG1960	acyl-CoA dehydrogenase activity
SB45_RS11235	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB45_RS11240	COG0183	Belongs to the thiolase family
SB45_RS11245	COG0584	glycerophosphoryl diester phosphodiesterase
SB45_RS11250	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB45_RS11275	COG1902	pentaerythritol trinitrate reductase activity
SB45_RS11290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SB45_RS11295	COG0745	RESPONSE REGULATOR receiver
SB45_RS11300	COG0750	zinc metalloprotease
SB45_RS11305	COG0497	DNA recombination
SB45_RS11315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SB45_RS11325	COG0142	geranyltranstransferase activity
SB45_RS11335	COG1570	exodeoxyribonuclease VII activity
SB45_RS11350	COG1302	Protein conserved in bacteria
SB45_RS11355	COG0439	Biotin carboxylase
SB45_RS11360	COG0511	ligase activity, forming carbon-carbon bonds
SB45_RS11400	COG3854	ATPases associated with a variety of cellular activities
SB45_RS11415	COG0006	proline dipeptidase activity
SB45_RS11425	COG3872	metal-dependent enzyme
SB45_RS11435	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB45_RS11450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB45_RS11470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB45_RS11485	COG1396	sequence-specific DNA binding
SB45_RS11495	COG0681	Belongs to the peptidase S26 family
SB45_RS11520	COG4940	Competence protein ComGF
SB45_RS11530	COG4970	Tfp pilus assembly protein FimT
SB45_RS11535	COG4537	Required for transformation and DNA binding
SB45_RS11540	COG1459	type II secretion system
SB45_RS11545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB45_RS11550	COG0598	Magnesium transport protein CorA
SB45_RS11555	COG1253	flavin adenine dinucleotide binding
SB45_RS11560	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS11570	COG1393	Belongs to the ArsC family
SB45_RS11580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS11590	COG0011	TIGRFAM Protein of
SB45_RS11600	COG2866	Carboxypeptidase
SB45_RS11605	COG1940	carbohydrate kinase activity
SB45_RS11610	COG4483	Protein conserved in bacteria
SB45_RS11615	COG1757	Na H antiporter
SB45_RS11620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SB45_RS11630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB45_RS11635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB45_RS11640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB45_RS11645	COG0581	inorganic phosphate transmembrane transporter activity
SB45_RS11650	COG0573	inorganic phosphate transmembrane transporter activity
SB45_RS11655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SB45_RS11660	COG0768	penicillin binding
SB45_RS11665	COG0477	Major facilitator Superfamily
SB45_RS11670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB45_RS11675	COG2839	Protein conserved in bacteria
SB45_RS11680	COG5521	maltodextrose utilization protein MalA
SB45_RS11685	COG1388	LysM domain
SB45_RS11695	COG4709	membrane
SB45_RS11700	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
SB45_RS11705	COG0735	belongs to the Fur family
SB45_RS11710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS11725	COG0513	Belongs to the DEAD box helicase family
SB45_RS11740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SB45_RS11745	COG2384	SAM-dependent methyltransferase
SB45_RS11750	COG2010	Cytochrome c
SB45_RS11755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SB45_RS11760	COG0358	DNA primase activity
SB45_RS11775	COG0517	IMP dehydrogenase activity
SB45_RS11780	COG0751	glycine-tRNA ligase activity
SB45_RS11795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SB45_RS11800	COG0295	cytidine deaminase activity
SB45_RS11805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SB45_RS11815	COG1480	7TM receptor with intracellular HD hydrolase
SB45_RS11820	COG1702	phosphate starvation-inducible protein PhoH
SB45_RS11825	COG0561	phosphatase activity
SB45_RS11840	COG4864	UPF0365 protein
SB45_RS11845	COG1030	water channel activity
SB45_RS11850	COG1610	YqeY-like protein
SB45_RS11860	COG1283	sodium-dependent phosphate transmembrane transporter activity
SB45_RS11865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB45_RS11870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SB45_RS11900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB45_RS11915	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB45_RS11930	COG1466	dna polymerase III delta subunit
SB45_RS11940	COG2333	competence protein COMEC
SB45_RS11940	COG0658	competence protein
SB45_RS11945	COG2131	deaminase
SB45_RS11950	COG1596	polysaccharide export
SB45_RS11950	COG1555	photosystem II stabilization
SB45_RS11955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB45_RS11960	COG2226	methyltransferase
SB45_RS11965	COG0799	negative regulation of ribosome biogenesis
SB45_RS11970	COG1713	HD superfamily hydrolase involved in NAD metabolism
SB45_RS11980	COG1534	Rna-binding protein
SB45_RS11985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SB45_RS11990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB45_RS11995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SB45_RS12005	COG2755	lipolytic protein G-D-S-L family
SB45_RS12015	COG0398	Pfam SNARE associated Golgi protein
SB45_RS12040	COG2207	Transcriptional regulator
SB45_RS12040	COG3708	Transcriptional regulator
SB45_RS12045	COG0563	adenylate kinase activity
SB45_RS12055	COG2814	Major facilitator Superfamily
SB45_RS12060	COG0456	acetyltransferase
SB45_RS12065	COG2318	DinB family
SB45_RS12075	COG0561	phosphatase activity
SB45_RS12080	COG0561	phosphatase activity
SB45_RS12090	COG1482	cell wall glycoprotein biosynthetic process
SB45_RS12095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB45_RS12095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB45_RS12095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS12100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS12100	COG3711	transcriptional antiterminator
SB45_RS12110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB45_RS12115	COG0583	DNA-binding transcription factor activity
SB45_RS12120	COG2814	Major facilitator Superfamily
SB45_RS12125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB45_RS12125	COG2124	cytochrome p450
SB45_RS12130	COG1309	transcriptional regulator
SB45_RS12135	COG2226	methyltransferase
SB45_RS12145	COG2116	formate transmembrane transporter activity
SB45_RS12150	COG5609	conserved protein (DUF2294)
SB45_RS12155	COG3383	formate dehydrogenase (NAD+) activity
SB45_RS12160	COG2427	Protein of unknown function (DUF1641)
SB45_RS12170	COG0626	cystathionine gamma-synthase activity
SB45_RS12175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB45_RS12200	COG0768	penicillin binding
SB45_RS12215	COG0826	peptidase U32
SB45_RS12220	COG0826	peptidase U32
SB45_RS12225	COG4122	O-methyltransferase activity
SB45_RS12230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB45_RS12245	COG4472	Bacterial protein of unknown function (DUF965)
SB45_RS12255	COG0628	permease
SB45_RS12260	COG1126	abc transporter atp-binding protein
SB45_RS12265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS12270	COG0765	amino acid transport
SB45_RS12275	COG0765	amino acid transport
SB45_RS12285	COG3881	PFAM PRC-barrel domain
SB45_RS12290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SB45_RS12295	COG0457	Tetratricopeptide repeat
SB45_RS12305	COG1104	cysteine desulfurase activity
SB45_RS12310	COG1959	2 iron, 2 sulfur cluster binding
SB45_RS12315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB45_RS12320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SB45_RS12335	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB45_RS12335	COG3103	Sh3 type 3 domain protein
SB45_RS12335	COG4991	sh3 domain protein
SB45_RS12345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB45_RS12355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SB45_RS12355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SB45_RS12360	COG5416	Lipopolysaccharide assembly protein A domain
SB45_RS12365	COG0490	domain, Protein
SB45_RS12370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB45_RS12370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB45_RS12380	COG2244	polysaccharide biosynthetic process
SB45_RS12385	COG2323	membrane
SB45_RS12395	COG1862	Preprotein translocase
SB45_RS12440	COG1388	LysM domain
SB45_RS12450	COG0157	Belongs to the NadC ModD family
SB45_RS12455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SB45_RS12460	COG1104	cysteine desulfurase activity
SB45_RS12465	COG1827	regulation of RNA biosynthetic process
SB45_RS12470	COG0077	Prephenate dehydratase
SB45_RS12485	COG3290	protein histidine kinase activity
SB45_RS12490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SB45_RS12495	COG2868	ribosomal protein
SB45_RS12505	COG1994	Peptidase M50
SB45_RS12510	COG0739	heme binding
SB45_RS12515	COG2894	cell division
SB45_RS12525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SB45_RS12535	COG1077	Cell shape determining protein MreB Mrl
SB45_RS12555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SB45_RS12560	COG0285	dihydrofolate synthase activity
SB45_RS12565	COG0525	valine-tRNA ligase activity
SB45_RS12575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB45_RS12580	COG1388	LysM domain
SB45_RS12590	COG0113	porphobilinogen synthase activity
SB45_RS12595	COG1587	Uroporphyrinogen-III synthase
SB45_RS12605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB45_RS12625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SB45_RS12630	COG1067	ATP-dependent peptidase activity
SB45_RS12630	COG0470	DNA polymerase III
SB45_RS12645	COG0457	Tetratricopeptide repeat
SB45_RS12645	COG1477	protein flavinylation
SB45_RS12660	COG0473	3-isopropylmalate dehydrogenase activity
SB45_RS12675	COG0440	acetolactate synthase activity
SB45_RS12680	COG0028	Belongs to the TPP enzyme family
SB45_RS12710	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SB45_RS12730	COG0622	Phosphoesterase
SB45_RS12735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SB45_RS12745	COG5401	PFAM Sporulation and spore germination
SB45_RS12755	COG1846	Transcriptional regulator
SB45_RS12760	COG2197	response regulator
SB45_RS12765	COG0824	Thioesterase
SB45_RS12770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SB45_RS12775	COG1053	succinate dehydrogenase
SB45_RS12780	COG2009	succinate dehydrogenase
SB45_RS12785	COG1719	4-vinyl reductase, 4VR
SB45_RS12790	COG0527	aspartate kinase activity
SB45_RS12800	COG3118	belongs to the thioredoxin family
SB45_RS12805	COG3534	alpha-L-arabinofuranosidase
SB45_RS12810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SB45_RS12815	COG2086	electron transfer activity
SB45_RS12820	COG1024	Enoyl-CoA hydratase
SB45_RS12825	COG1309	transcriptional regulator
SB45_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
SB45_RS12840	COG3766	membrane
SB45_RS12850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB45_RS12850	COG1796	DNA polymerase
SB45_RS12855	COG1286	toxin biosynthetic process
SB45_RS12870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB45_RS12870	COG0072	phenylalanine-tRNA ligase activity
SB45_RS12875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SB45_RS12880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB45_RS12890	COG3835	regulator
SB45_RS12895	COG0277	FAD linked oxidase domain protein
SB45_RS12900	COG0247	lactate metabolic process
SB45_RS12905	COG1966	Carbon starvation protein
SB45_RS12910	COG3534	alpha-L-arabinofuranosidase
SB45_RS12915	COG0395	ABC-type sugar transport system, permease component
SB45_RS12920	COG1175	transmembrane transport
SB45_RS12925	COG1653	transport
SB45_RS12935	COG0647	UMP catabolic process
SB45_RS12940	COG0235	Class ii aldolase
SB45_RS12945	COG1069	ribulokinase activity
SB45_RS12950	COG2160	L-arabinose isomerase activity
SB45_RS12955	COG3507	Belongs to the glycosyl hydrolase 43 family
SB45_RS12960	COG1363	Peptidase, m42
SB45_RS12970	COG3326	Membrane
SB45_RS12975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SB45_RS12985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SB45_RS12990	COG1346	cytolysis
SB45_RS12995	COG1380	Effector of murein hydrolase LrgA
SB45_RS13000	COG3279	Response regulator of the LytR AlgR family
SB45_RS13005	COG3275	phosphorelay sensor kinase activity
SB45_RS13010	COG1011	Hydrolase
SB45_RS13025	COG0398	Pfam SNARE associated Golgi protein
SB45_RS13030	COG1484	DNA-dependent DNA replication
SB45_RS13035	COG3611	Membrane attachment protein
SB45_RS13050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB45_RS13055	COG1733	regulation of RNA biosynthetic process
SB45_RS13060	COG2814	Major facilitator Superfamily
SB45_RS13065	COG0656	L-ascorbic acid biosynthetic process
SB45_RS13070	COG0237	dephospho-CoA kinase activity
SB45_RS13075	COG1971	Probably functions as a manganese efflux pump
SB45_RS13080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB45_RS13085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB45_RS13085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB45_RS13090	COG5002	protein histidine kinase activity
SB45_RS13095	COG0745	RESPONSE REGULATOR receiver
SB45_RS13105	COG0538	isocitrate dehydrogenase activity
SB45_RS13110	COG0372	Belongs to the citrate synthase family
SB45_RS13125	COG0628	permease
SB45_RS13130	COG3030	protein affecting phage T7 exclusion by the F plasmid
SB45_RS13135	COG0469	pyruvate kinase activity
SB45_RS13160	COG0281	malic enzyme
SB45_RS13165	COG0587	DNA-directed DNA polymerase activity
SB45_RS13185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SB45_RS13195	COG4109	DRTGG domain
SB45_RS13205	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS13220	COG0521	Mo-molybdopterin cofactor biosynthetic process
SB45_RS13230	COG0827	DNA restriction-modification system
SB45_RS13235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SB45_RS13240	COG3874	Sporulation protein YtfJ
SB45_RS13250	COG1714	RDD family
SB45_RS13255	COG0616	signal peptide processing
SB45_RS13260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SB45_RS13265	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SB45_RS13270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB45_RS13285	COG1104	cysteine desulfurase activity
SB45_RS13290	COG1114	Component of the transport system for branched-chain amino acids
SB45_RS13300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB45_RS13305	COG1309	transcriptional regulator
SB45_RS13310	COG1956	GAF domain-containing protein
SB45_RS13315	COG2199	diguanylate cyclase activity
SB45_RS13315	COG2203	Gaf domain
SB45_RS13325	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS13330	COG4282	regulation of fungal-type cell wall biogenesis
SB45_RS13335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SB45_RS13335	COG1017	nitric oxide dioxygenase activity
SB45_RS13345	COG0693	protein deglycase activity
SB45_RS13360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB45_RS13365	COG1378	Sugar-specific transcriptional regulator TrmB
SB45_RS13385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB45_RS13390	COG0454	-acetyltransferase
SB45_RS13395	COG0517	IMP dehydrogenase activity
SB45_RS13400	COG0123	including yeast histone deacetylase and acetoin utilization protein
SB45_RS13405	COG1360	Flagellar Motor Protein
SB45_RS13410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB45_RS13415	COG1609	Transcriptional regulator
SB45_RS13420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SB45_RS13420	COG1605	Chorismate mutase
SB45_RS13425	COG3118	belongs to the thioredoxin family
SB45_RS13430	COG4980	gas vesicle protein
SB45_RS13435	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SB45_RS13445	COG1674	ftsk spoiiie
SB45_RS13450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB45_RS13460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS13470	COG1363	Peptidase, m42
SB45_RS13475	COG5584	Small secreted protein
SB45_RS13480	COG0281	malic enzyme
SB45_RS13485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB45_RS13500	COG0510	thiamine kinase activity
SB45_RS13505	COG1597	lipid kinase activity
SB45_RS13515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SB45_RS13520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB45_RS13525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB45_RS13530	COG2252	PERMEase
SB45_RS13535	COG4473	ABC transporter
SB45_RS13540	COG1131	(ABC) transporter
SB45_RS13545	COG1187	pseudouridine synthase activity
SB45_RS13550	COG2244	polysaccharide biosynthetic process
SB45_RS13555	COG2081	HI0933 family
SB45_RS13560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SB45_RS13570	COG1609	Transcriptional regulator
SB45_RS13575	COG1653	transport
SB45_RS13580	COG1175	transmembrane transport
SB45_RS13585	COG0395	ABC-type sugar transport system, permease component
SB45_RS13590	COG1486	melibiose metabolic process
SB45_RS13600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB45_RS13615	COG1366	Belongs to the anti-sigma-factor antagonist family
SB45_RS13615	COG2202	Pas domain
SB45_RS13620	COG2814	Major facilitator Superfamily
SB45_RS13625	COG5522	Integral membrane protein (intg_mem_TP0381)
SB45_RS13630	COG0577	efflux transmembrane transporter activity
SB45_RS13635	COG1136	(ABC) transporter
SB45_RS13640	COG2205	protein histidine kinase activity
SB45_RS13645	COG0745	RESPONSE REGULATOR receiver
SB45_RS13650	COG0577	efflux transmembrane transporter activity
SB45_RS13655	COG1136	(ABC) transporter
SB45_RS13675	COG1131	(ABC) transporter
SB45_RS13680	COG1725	Transcriptional regulator
SB45_RS13690	COG1242	4 iron, 4 sulfur cluster binding
SB45_RS13695	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SB45_RS13705	COG0584	glycerophosphoryl diester phosphodiesterase
SB45_RS13715	COG2267	carboxylic ester hydrolase activity
SB45_RS13720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SB45_RS13725	COG1113	amino acid transport
SB45_RS13730	COG0367	asparagine synthase
SB45_RS13750	COG1506	peptidase
SB45_RS13755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB45_RS13760	COG1116	anion transmembrane transporter activity
SB45_RS13765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB45_RS13770	COG0494	nUDIX hydrolase
SB45_RS13775	COG4824	toxin secretion phage lysis holin
SB45_RS13780	COG0783	Belongs to the Dps family
SB45_RS13805	COG0288	reversible hydration of carbon dioxide
SB45_RS13815	COG1271	oxidase subunit
SB45_RS13820	COG1294	oxidase, subunit
SB45_RS13825	COG4948	Mandelate Racemase Muconate Lactonizing
SB45_RS13835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SB45_RS13840	COG0596	Alpha beta hydrolase
SB45_RS13850	COG1169	isochorismate synthase
SB45_RS13855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB45_RS13860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SB45_RS13980	COG3859	Proton-coupled thiamine transporter YuaJ
SB45_RS13985	COG2268	Band 7 protein
SB45_RS13990	COG1585	Membrane protein implicated in regulation of membrane protease activity
SB45_RS13995	COG2318	DinB family
SB45_RS14005	COG1454	alcohol dehydrogenase
SB45_RS14010	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS14015	COG1510	regulation of RNA biosynthetic process
SB45_RS14025	COG0569	domain protein
SB45_RS14030	COG1705	Flagellar rod assembly protein muramidase FlgJ
SB45_RS14035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SB45_RS14035	COG1017	nitric oxide dioxygenase activity
SB45_RS14060	COG0628	permease
SB45_RS14065	COG0673	inositol 2-dehydrogenase activity
SB45_RS14070	COG0693	protein deglycase activity
SB45_RS14075	COG0840	transmembrane signaling receptor activity
SB45_RS14080	COG0840	transmembrane signaling receptor activity
SB45_RS14085	COG0840	transmembrane signaling receptor activity
SB45_RS14090	COG0840	transmembrane signaling receptor activity
SB45_RS14105	COG2070	2-Nitropropane dioxygenase
SB45_RS14110	COG0432	Pfam Uncharacterised protein family UPF0047
SB45_RS14115	COG0366	Alpha amylase catalytic
SB45_RS14120	COG1253	flavin adenine dinucleotide binding
SB45_RS14125	COG2738	Putative neutral zinc metallopeptidase
SB45_RS14140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SB45_RS14165	COG1335	isochorismatase
SB45_RS14170	COG1979	alcohol dehydrogenase
SB45_RS14175	COG1979	alcohol dehydrogenase
SB45_RS14180	COG2155	Conserved Protein
SB45_RS14185	COG1098	S1 RNA binding domain
SB45_RS14190	COG0436	Aminotransferase
SB45_RS14195	COG1522	sequence-specific DNA binding
SB45_RS14200	COG2267	carboxylic ester hydrolase activity
SB45_RS14210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SB45_RS14215	COG2205	protein histidine kinase activity
SB45_RS14225	COG5018	Exonuclease
SB45_RS14230	COG2814	Major facilitator Superfamily
SB45_RS14235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB45_RS14240	COG3011	Protein conserved in bacteria
SB45_RS14250	COG3290	protein histidine kinase activity
SB45_RS14255	COG4565	transcriptional regulatory protein
SB45_RS14260	COG1744	ABC transporter substrate-binding protein PnrA-like
SB45_RS14265	COG3845	ABC transporter
SB45_RS14270	COG4603	Belongs to the binding-protein-dependent transport system permease family
SB45_RS14275	COG1079	Belongs to the binding-protein-dependent transport system permease family
SB45_RS14285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SB45_RS14285	COG2111	Na H antiporter
SB45_RS14290	COG2111	Na H antiporter
SB45_RS14295	COG1006	Multisubunit Na H antiporter MnhC subunit
SB45_RS14300	COG0651	ATP synthesis coupled electron transport
SB45_RS14305	COG1863	multisubunit Na H antiporter MnhE subunit
SB45_RS14310	COG2212	antiporter activity
SB45_RS14315	COG1320	monovalent cation:proton antiporter activity
SB45_RS14320	COG2050	protein possibly involved in aromatic compounds catabolism
SB45_RS14325	COG2197	response regulator
SB45_RS14330	COG4585	Histidine kinase
SB45_RS14340	COG0142	geranyltranstransferase activity
SB45_RS14355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SB45_RS14360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SB45_RS14365	COG1335	isochorismatase
SB45_RS14370	COG5506	Protein of unknown function (DUF1694)
SB45_RS14385	COG0628	permease
SB45_RS14395	COG1418	mRNA catabolic process
SB45_RS14400	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS14410	COG1511	domain protein
SB45_RS14415	COG0433	COG0433 Predicted ATPase
SB45_RS14415	COG1674	ftsk spoiiie
SB45_RS14420	COG4499	WXG100 protein secretion system (Wss), protein YukC
SB45_RS14425	COG5417	Belongs to the EsaB family
SB45_RS14430	COG4842	Belongs to the WXG100 family
SB45_RS14435	COG2508	Transcriptional regulator
SB45_RS14435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SB45_RS14440	COG0686	Belongs to the AlaDH PNT family
SB45_RS14445	COG5634	Uncharacterized conserved protein (DUF2278)
SB45_RS14450	COG3251	PFAM MbtH domain protein
SB45_RS14455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB45_RS14460	COG3433	isochorismatase activity
SB45_RS14460	COG1535	isochorismatase
SB45_RS14465	COG1021	2,3-dihydroxybenzoate-AMP ligase
SB45_RS14470	COG1169	isochorismate synthase
SB45_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS14480	COG2819	hydrolase of the alpha beta superfamily
SB45_RS14485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB45_RS14490	COG1268	BioY protein
SB45_RS14495	COG2056	Na+-H+ antiporter family
SB45_RS14505	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SB45_RS14510	COG3584	3D domain protein
SB45_RS14520	COG1252	NADH dehydrogenase
SB45_RS14550	COG1131	(ABC) transporter
SB45_RS14575	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SB45_RS14580	COG0316	Belongs to the HesB IscA family
SB45_RS14590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB45_RS14600	COG1252	NADH dehydrogenase
SB45_RS14605	COG4837	Protein of unknown function (DUF1462)
SB45_RS14610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SB45_RS14615	COG1506	peptidase
SB45_RS14615	COG0823	Involved in the tonB-independent uptake of proteins
SB45_RS14615	COG4946	Tricorn protease homolog
SB45_RS14625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SB45_RS14630	COG0460	homoserine dehydrogenase
SB45_RS14635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB45_RS14640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SB45_RS14645	COG0647	UMP catabolic process
SB45_RS14650	COG2445	Protein of unknown function DUF86
SB45_RS14655	COG4470	Protein conserved in bacteria
SB45_RS14665	COG0739	heme binding
SB45_RS14675	COG0737	Belongs to the 5'-nucleotidase family
SB45_RS14680	COG0730	response to heat
SB45_RS14685	COG1801	Protein of unknown function DUF72
SB45_RS14700	COG2508	Transcriptional regulator
SB45_RS14725	COG2814	Major facilitator Superfamily
SB45_RS14730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB45_RS14735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB45_RS14740	COG2356	endonuclease I
SB45_RS14745	COG3842	ATPase activity
SB45_RS14750	COG2188	Transcriptional regulator
SB45_RS14755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB45_RS14760	COG0395	ABC-type sugar transport system, permease component
SB45_RS14765	COG1175	transmembrane transport
SB45_RS14770	COG1653	transport
SB45_RS14775	COG2222	sugar isomerase
SB45_RS14785	COG0322	excinuclease ABC activity
SB45_RS14790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB45_RS14800	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS14805	COG0719	Fe-S assembly protein
SB45_RS14810	COG0822	iron-sulfur transferase activity
SB45_RS14815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB45_RS14820	COG0719	Fe-S assembly protein
SB45_RS14825	COG0396	ATPase activity
SB45_RS14830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SB45_RS14835	COG1464	Belongs to the NlpA lipoprotein family
SB45_RS14840	COG2011	ABC-type metal ion transport system permease component
SB45_RS14845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SB45_RS14855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB45_RS14860	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SB45_RS14875	COG1393	Belongs to the ArsC family
SB45_RS14880	COG1960	acyl-CoA dehydrogenase activity
SB45_RS14885	COG0183	Belongs to the thiolase family
SB45_RS14890	COG1024	Enoyl-CoA hydratase
SB45_RS14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB45_RS14905	COG5577	PFAM Coat F domain
SB45_RS14910	COG1846	Transcriptional regulator
SB45_RS14915	COG0477	Major facilitator Superfamily
SB45_RS14920	COG0583	DNA-binding transcription factor activity
SB45_RS14940	COG1120	ATPase activity
SB45_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS14960	COG0783	Belongs to the Dps family
SB45_RS14965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB45_RS14970	COG0745	RESPONSE REGULATOR receiver
SB45_RS14975	COG2205	protein histidine kinase activity
SB45_RS14975	COG2770	Histidine kinase
SB45_RS14980	COG1309	transcriptional regulator
SB45_RS14985	COG0114	fumarate hydratase activity
SB45_RS14995	COG0697	spore germination
SB45_RS15000	COG0814	amino acid
SB45_RS15010	COG2197	response regulator
SB45_RS15015	COG4585	Histidine kinase
SB45_RS15020	COG4758	membrane
SB45_RS15025	COG3595	metallopeptidase activity
SB45_RS15030	COG1842	Phage shock protein A
SB45_RS15035	COG4758	membrane
SB45_RS15040	COG2814	Major facilitator Superfamily
SB45_RS15045	COG2096	Adenosyltransferase
SB45_RS15050	COG1120	ATPase activity
SB45_RS15055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS15060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB45_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS15070	COG3386	PFAM SMP-30 Gluconolaconase
SB45_RS15075	COG2205	protein histidine kinase activity
SB45_RS15080	COG0745	RESPONSE REGULATOR receiver
SB45_RS15090	COG1191	sigma factor activity
SB45_RS15095	COG2140	Oxalate decarboxylase
SB45_RS15105	COG1120	ATPase activity
SB45_RS15110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS15115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS15120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB45_RS15125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SB45_RS15130	COG0531	amino acid
SB45_RS15140	COG1988	membrane-bound metal-dependent
SB45_RS15145	COG1368	sulfuric ester hydrolase activity
SB45_RS15150	COG1910	domain protein
SB45_RS15155	COG0725	ABC transporter, periplasmic molybdate-binding protein
SB45_RS15160	COG4149	molybdate abc transporter
SB45_RS15165	COG2197	response regulator
SB45_RS15170	COG3850	Histidine kinase
SB45_RS15175	COG1131	(ABC) transporter
SB45_RS15185	COG0842	Transport permease protein
SB45_RS15190	COG0656	L-ascorbic acid biosynthetic process
SB45_RS15215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB45_RS15220	COG3973	AAA domain
SB45_RS15225	COG2860	membrane
SB45_RS15235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SB45_RS15240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SB45_RS15245	COG2217	Heavy metal translocating P-type atpase
SB45_RS15250	COG2217	Heavy metal translocating P-type atpase
SB45_RS15255	COG2608	mercury ion transmembrane transporter activity
SB45_RS15260	COG1937	Protein conserved in bacteria
SB45_RS15265	COG0673	inositol 2-dehydrogenase activity
SB45_RS15280	COG2814	Major facilitator Superfamily
SB45_RS15295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS15300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SB45_RS15305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS15310	COG1126	abc transporter atp-binding protein
SB45_RS15315	COG0765	amino acid transport
SB45_RS15320	COG0765	amino acid transport
SB45_RS15325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS15330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB45_RS15335	COG0454	-acetyltransferase
SB45_RS15340	COG0583	DNA-binding transcription factor activity
SB45_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS15350	COG2732	(Barnase) inhibitor
SB45_RS15360	COG0557	exoribonuclease II activity
SB45_RS15365	COG1647	Serine aminopeptidase, S33
SB45_RS15370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB45_RS15375	COG1476	TRANSCRIPTIONal
SB45_RS15380	COG1396	sequence-specific DNA binding
SB45_RS15385	COG1396	sequence-specific DNA binding
SB45_RS15390	COG1733	regulation of RNA biosynthetic process
SB45_RS15415	COG1131	(ABC) transporter
SB45_RS15420	COG1174	glycine betaine transport
SB45_RS15425	COG1732	Glycine betaine
SB45_RS15430	COG1174	glycine betaine transport
SB45_RS15435	COG0517	IMP dehydrogenase activity
SB45_RS15435	COG1125	glycine betaine transport
SB45_RS15440	COG1510	regulation of RNA biosynthetic process
SB45_RS15445	COG1174	glycine betaine transport
SB45_RS15450	COG1732	Glycine betaine
SB45_RS15455	COG1174	glycine betaine transport
SB45_RS15460	COG1125	glycine betaine transport
SB45_RS15460	COG0517	IMP dehydrogenase activity
SB45_RS15465	COG1510	regulation of RNA biosynthetic process
SB45_RS15470	COG2095	MarC family integral membrane protein
SB45_RS15475	COG3064	Membrane
SB45_RS15480	COG4640	response to antibiotic
SB45_RS15485	COG0456	acetyltransferase
SB45_RS15500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB45_RS15515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB45_RS15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB45_RS15525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB45_RS15535	COG2234	aminopeptidase activity
SB45_RS15555	COG0126	phosphoglycerate kinase activity
SB45_RS15565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB45_RS15570	COG2390	Transcriptional regulator
SB45_RS15575	COG2814	Major facilitator Superfamily
SB45_RS15580	COG1609	Transcriptional regulator
SB45_RS15585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS15595	COG0583	DNA-binding transcription factor activity
SB45_RS15600	COG0697	spore germination
SB45_RS15605	COG1113	amino acid transport
SB45_RS15610	COG1737	Transcriptional regulator
SB45_RS15615	COG1070	Carbohydrate kinase
SB45_RS15640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB45_RS15645	COG2186	Transcriptional regulator
SB45_RS15650	COG1620	l-lactate permease
SB45_RS15655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SB45_RS15665	COG5039	Polysaccharide pyruvyl transferase
SB45_RS15670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB45_RS15675	COG0110	maltose O-acetyltransferase activity
SB45_RS15680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SB45_RS15685	COG2244	polysaccharide biosynthetic process
SB45_RS15690	COG1216	Glycosyl transferase, family 2
SB45_RS15695	COG5039	Polysaccharide pyruvyl transferase
SB45_RS15700	COG1216	Glycosyl transferase, family 2
SB45_RS15710	COG0438	transferase activity, transferring glycosyl groups
SB45_RS15715	COG1215	transferase activity, transferring glycosyl groups
SB45_RS15720	COG0438	transferase activity, transferring glycosyl groups
SB45_RS15725	COG1086	Polysaccharide biosynthesis protein
SB45_RS15730	COG0489	protein tyrosine kinase activity
SB45_RS15735	COG3944	biosynthesis protein
SB45_RS15740	COG1396	sequence-specific DNA binding
SB45_RS15745	COG2272	Belongs to the type-B carboxylesterase lipase family
SB45_RS15750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB45_RS15755	COG2364	Membrane
SB45_RS15760	COG0456	acetyltransferase
SB45_RS15765	COG3479	Phenolic acid decarboxylase
SB45_RS15815	COG2223	nitrite transmembrane transporter activity
SB45_RS15820	COG1609	Transcriptional regulator
SB45_RS15830	COG0583	DNA-binding transcription factor activity
SB45_RS15835	COG2828	Protein conserved in bacteria
SB45_RS15840	COG0477	Major facilitator Superfamily
SB45_RS15840	COG2814	Major facilitator Superfamily
SB45_RS15845	COG1611	Belongs to the LOG family
SB45_RS15850	COG1694	Mazg nucleotide pyrophosphohydrolase
SB45_RS15855	COG0659	secondary active sulfate transmembrane transporter activity
SB45_RS15860	COG0288	reversible hydration of carbon dioxide
SB45_RS15870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB45_RS15875	COG4290	ribonuclease
SB45_RS15880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SB45_RS15885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS15895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SB45_RS15905	COG1051	belongs to the nudix hydrolase family
SB45_RS15910	COG0492	ferredoxin-NADP+ reductase activity
SB45_RS15915	COG0791	NLP P60 protein
SB45_RS15915	COG3883	PFAM NLP P60 protein
SB45_RS15920	COG0457	Tetratricopeptide repeat
SB45_RS15925	COG5002	protein histidine kinase activity
SB45_RS15930	COG0745	RESPONSE REGULATOR receiver
SB45_RS15940	COG1132	(ABC) transporter
SB45_RS15945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SB45_RS15945	COG0140	phosphoribosyl-ATP diphosphatase activity
SB45_RS15970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SB45_RS15985	COG4990	cell redox homeostasis
SB45_RS15990	COG0110	maltose O-acetyltransferase activity
SB45_RS16010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SB45_RS16020	COG2188	Transcriptional regulator
SB45_RS16025	COG1309	transcriptional regulator
SB45_RS16030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SB45_RS16035	COG1950	PFAM Membrane protein of
SB45_RS16040	COG1983	PspC domain protein
SB45_RS16045	COG3595	metallopeptidase activity
SB45_RS16060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SB45_RS16070	COG4897	Protein conserved in bacteria
SB45_RS16075	COG3848	Pyruvate phosphate dikinase
SB45_RS16075	COG0574	Belongs to the PEP-utilizing enzyme family
SB45_RS16080	COG1309	transcriptional regulator
SB45_RS16085	COG2814	Major facilitator Superfamily
SB45_RS16110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB45_RS16120	COG0793	Belongs to the peptidase S41A family
SB45_RS16120	COG3409	Peptidoglycan-binding domain 1 protein
SB45_RS16125	COG3420	alginic acid biosynthetic process
SB45_RS16130	COG2177	Part of the ABC transporter FtsEX involved in
SB45_RS16135	COG2884	Cell division ATP-binding protein ftsE
SB45_RS16140	COG2010	Cytochrome c
SB45_RS16145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS16160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SB45_RS16175	COG1516	flagellar protein fliS
SB45_RS16180	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SB45_RS16185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB45_RS16205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB45_RS16210	COG4786	Flagellar basal body rod
SB45_RS16210	COG1256	bacterial-type flagellum assembly
SB45_RS16215	COG3418	PFAM FlgN family protein
SB45_RS16220	COG2747	anti-sigma28 factor FlgM
SB45_RS16230	COG1040	competence protein
SB45_RS16240	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SB45_RS16245	COG1307	EDD domain protein, DegV family
SB45_RS16250	COG2197	response regulator
SB45_RS16255	COG4585	Histidine kinase
SB45_RS16260	COG1739	Uncharacterized protein family UPF0029
SB45_RS16265	COG1316	TRANSCRIPTIONal
SB45_RS16270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB45_RS16275	COG0438	transferase activity, transferring glycosyl groups
SB45_RS16280	COG1215	transferase activity, transferring glycosyl groups
SB45_RS16285	COG3206	protein involved in exopolysaccharide biosynthesis
SB45_RS16290	COG3307	-O-antigen
SB45_RS16295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB45_RS16300	COG0297	glycogen (starch) synthase activity
SB45_RS16300	COG0438	transferase activity, transferring glycosyl groups
SB45_RS16305	COG2244	polysaccharide biosynthetic process
SB45_RS16315	COG2247	cell wall binding repeat
SB45_RS16315	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB45_RS16320	COG2385	sporulation resulting in formation of a cellular spore
SB45_RS16320	COG2247	cell wall binding repeat
SB45_RS16330	COG1316	TRANSCRIPTIONal
SB45_RS16335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SB45_RS16340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB45_RS16345	COG1134	teichoic acid transport
SB45_RS16350	COG1682	transport, permease protein
SB45_RS16355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB45_RS16365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SB45_RS16370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SB45_RS16375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB45_RS16380	COG4193	domain, Protein
SB45_RS16385	COG1482	cell wall glycoprotein biosynthetic process
SB45_RS16390	COG0697	spore germination
SB45_RS16395	COG0814	amino acid
SB45_RS16405	COG1215	transferase activity, transferring glycosyl groups
SB45_RS16410	COG2814	Major facilitator Superfamily
SB45_RS16415	COG1316	TRANSCRIPTIONal
SB45_RS16420	COG0561	phosphatase activity
SB45_RS16425	COG2433	Pfam Transposase IS66
SB45_RS16430	COG0791	NLP P60 protein
SB45_RS16435	COG2843	Capsule synthesis protein
SB45_RS16445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SB45_RS16450	COG0697	spore germination
SB45_RS16455	COG0814	amino acid
SB45_RS16465	COG1609	Transcriptional regulator
SB45_RS16470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB45_RS16480	COG1129	ABC transporter
SB45_RS16485	COG1172	Belongs to the binding-protein-dependent transport system permease family
SB45_RS16490	COG1879	ABC-type sugar transport system periplasmic component
SB45_RS16495	COG3103	Sh3 type 3 domain protein
SB45_RS16500	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB45_RS16505	COG3527	Alpha-acetolactate decarboxylase
SB45_RS16510	COG0028	Belongs to the TPP enzyme family
SB45_RS16515	COG0583	DNA-binding transcription factor activity
SB45_RS16520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SB45_RS16535	COG5337	Spore coat protein CotH
SB45_RS16545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SB45_RS16560	COG1522	sequence-specific DNA binding
SB45_RS16565	COG2059	Chromate
SB45_RS16570	COG2059	Chromate
SB45_RS16580	COG0655	NAD(P)H dehydrogenase (quinone) activity
SB45_RS16585	COG0583	DNA-binding transcription factor activity
SB45_RS16605	COG5444	nuclease activity
SB45_RS16620	COG3878	Protein conserved in bacteria
SB45_RS16625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB45_RS16630	COG4464	protein tyrosine phosphatase activity
SB45_RS16635	COG0489	protein tyrosine kinase activity
SB45_RS16640	COG3944	biosynthesis protein
SB45_RS16650	COG4715	Zinc finger, swim domain protein
SB45_RS16655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB45_RS16660	COG0561	phosphatase activity
SB45_RS16665	COG1349	DNA-binding transcription factor activity
SB45_RS16670	COG0629	single-stranded DNA binding
SB45_RS16695	COG0457	Tetratricopeptide repeat
SB45_RS16700	COG4786	Flagellar basal body rod
SB45_RS16705	COG4786	Flagellar basal body rod
SB45_RS16710	COG1077	Cell shape determining protein MreB Mrl
SB45_RS16715	COG1609	Transcriptional regulator
SB45_RS16720	COG1846	Transcriptional regulator
SB45_RS16725	COG2814	Major facilitator Superfamily
SB45_RS16730	COG1953	Uracil, thiamine, allantoin
SB45_RS16735	COG0477	Major facilitator Superfamily
SB45_RS16740	COG1335	isochorismatase
SB45_RS16745	COG0004	ammonium transporteR
SB45_RS16750	COG0347	Belongs to the P(II) protein family
SB45_RS16755	COG0772	Belongs to the SEDS family
SB45_RS16760	COG0671	phosphoesterase, PA-phosphatase related
SB45_RS16770	COG0739	heme binding
SB45_RS16775	COG1247	-acetyltransferase
SB45_RS16790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB45_RS16800	COG0726	polysaccharide deacetylase
SB45_RS16810	COG1959	2 iron, 2 sulfur cluster binding
SB45_RS16825	COG0831	urea catabolic process
SB45_RS16830	COG3237	CsbD-like
SB45_RS16835	COG1994	Peptidase M50
SB45_RS16840	COG0457	Tetratricopeptide repeat
SB45_RS16850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SB45_RS16855	COG2304	oxidoreductase activity
SB45_RS16860	COG2304	oxidoreductase activity
SB45_RS16865	COG2385	sporulation resulting in formation of a cellular spore
SB45_RS16870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB45_RS16880	COG4836	Membrane
SB45_RS16950	COG0698	ribose 5-phosphate isomerase
SB45_RS16955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SB45_RS16965	COG0009	L-threonylcarbamoyladenylate synthase
SB45_RS16970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SB45_RS16990	COG2890	protein-(glutamine-N5) methyltransferase activity
SB45_RS16995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SB45_RS17000	COG0346	lactoylglutathione lyase activity
SB45_RS17005	COG0789	Transcriptional regulator
SB45_RS17010	COG0679	Auxin Efflux Carrier
SB45_RS17015	COG0281	malic enzyme
SB45_RS17030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SB45_RS17035	COG1494	fructose-1,6-bisphosphatase
SB45_RS17040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB45_RS17050	COG0191	fructose-bisphosphate aldolase activity
SB45_RS17055	COG2204	response regulator
SB45_RS17060	COG4821	SIS domain
SB45_RS17075	COG2181	nitrate reductase activity
SB45_RS17075	COG0247	lactate metabolic process
SB45_RS17080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB45_RS17095	COG1132	(ABC) transporter
SB45_RS17100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB45_RS17110	COG2181	nitrate reductase activity
SB45_RS17115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SB45_RS17120	COG1140	nitrate reductase beta subunit
SB45_RS17125	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SB45_RS17130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB45_RS17140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB45_RS17145	COG2223	nitrite transmembrane transporter activity
SB45_RS17155	COG4506	Protein conserved in bacteria
SB45_RS17160	COG0457	Tetratricopeptide repeat
SB45_RS17195	COG0010	Belongs to the arginase family
SB45_RS17200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SB45_RS17205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB45_RS17220	COG1994	Peptidase M50
SB45_RS17225	COG1942	4-Oxalocrotonate Tautomerase
SB45_RS17230	COG1846	Transcriptional regulator
SB45_RS17240	COG0531	amino acid
SB45_RS17245	COG3465	dGTPase activity
SB45_RS17250	COG1078	dGTPase activity
SB45_RS17265	COG1695	Transcriptional regulator
SB45_RS17280	COG0583	DNA-binding transcription factor activity
SB45_RS17285	COG2855	membrane
SB45_RS17290	COG0280	phosphate acetyltransferase
SB45_RS17300	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS17305	COG0436	Aminotransferase
SB45_RS17335	COG2814	Major facilitator Superfamily
SB45_RS17340	COG2814	Major facilitator Superfamily
SB45_RS17345	COG0833	amino acid
SB45_RS17350	COG4187	Peptidase family M20/M25/M40
SB45_RS17355	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS17360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB45_RS17370	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SB45_RS17375	COG1091	dTDP-4-dehydrorhamnose reductase activity
SB45_RS17380	COG1088	dTDP-glucose 4,6-dehydratase activity
SB45_RS17385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SB45_RS17390	COG3980	spore coat polysaccharide biosynthesis protein
SB45_RS17395	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SB45_RS17400	COG2089	acid synthase
SB45_RS17405	COG0456	acetyltransferase
SB45_RS17410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB45_RS17415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB45_RS17420	COG0463	Glycosyl transferase, family 2
SB45_RS17430	COG2363	Small membrane protein
SB45_RS17435	COG2233	PERMEase
SB45_RS17450	COG1216	Glycosyl transferase, family 2
SB45_RS17465	COG1695	Transcriptional regulator
SB45_RS17470	COG0351	phosphomethylpyrimidine kinase
SB45_RS17480	COG1621	beta-fructofuranosidase activity
SB45_RS17485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS17485	COG1263	PTS System
SB45_RS17490	COG3711	transcriptional antiterminator
SB45_RS17500	COG1404	Belongs to the peptidase S8 family
SB45_RS17505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB45_RS17510	COG0778	Nitroreductase
SB45_RS17515	COG1136	(ABC) transporter
SB45_RS17535	COG0772	Belongs to the SEDS family
SB45_RS17540	COG0454	-acetyltransferase
SB45_RS17560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SB45_RS17565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB45_RS17570	COG2261	transglycosylase associated protein
SB45_RS17575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB45_RS17580	COG2246	polysaccharide biosynthetic process
SB45_RS17585	COG1309	transcriptional regulator
SB45_RS17605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB45_RS17610	COG2837	iron assimilation
SB45_RS17615	COG2822	iron ion transport
SB45_RS17630	COG0583	DNA-binding transcription factor activity
SB45_RS17640	COG1346	cytolysis
SB45_RS17645	COG4895	conserved protein (DUF2196)
SB45_RS17650	COG0789	Transcriptional regulator
SB45_RS17655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SB45_RS17660	COG0346	lactoylglutathione lyase activity
SB45_RS17665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS17670	COG1404	Belongs to the peptidase S8 family
SB45_RS17675	COG1442	glycosyl transferase family 8
SB45_RS17680	COG2357	RelA SpoT domain protein
SB45_RS17685	COG1575	Belongs to the MenA family. Type 1 subfamily
SB45_RS17700	COG1696	Membrane protein involved in D-alanine export
SB45_RS17710	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SB45_RS17715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB45_RS17720	COG1486	melibiose metabolic process
SB45_RS17725	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB45_RS17730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS17735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS17740	COG3711	transcriptional antiterminator
SB45_RS17740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB45_RS17750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS17755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB45_RS17765	COG0640	Transcriptional regulator
SB45_RS17770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SB45_RS17775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS17780	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB45_RS17785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB45_RS17790	COG2723	6-phospho-beta-galactosidase activity
SB45_RS17795	COG1940	carbohydrate kinase activity
SB45_RS17800	COG1482	cell wall glycoprotein biosynthetic process
SB45_RS17810	COG0753	catalase activity
SB45_RS17815	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SB45_RS17820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB45_RS17825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SB45_RS17830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SB45_RS17835	COG4988	ABC transporter
SB45_RS17840	COG1294	oxidase, subunit
SB45_RS17845	COG1271	oxidase subunit
SB45_RS17850	COG3493	citrate carrier protein
SB45_RS17855	COG0726	polysaccharide deacetylase
SB45_RS17860	COG3842	ATPase activity
SB45_RS17865	COG2508	Transcriptional regulator
SB45_RS17870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS17880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB45_RS17890	COG4894	glucomannan catabolic process
SB45_RS17895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB45_RS17900	COG0500	methyltransferase
SB45_RS17905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB45_RS17925	COG0753	catalase activity
SB45_RS17925	COG0693	protein deglycase activity
SB45_RS17930	COG2851	Citrate transporter
SB45_RS17935	COG2273	Hydrolase Family 16
SB45_RS17945	COG2270	Major facilitator Superfamily
SB45_RS17950	COG0513	Belongs to the DEAD box helicase family
SB45_RS18020	COG0697	spore germination
SB45_RS18025	COG0589	response to stress
SB45_RS18030	COG2723	6-phospho-beta-galactosidase activity
SB45_RS18035	COG2190	(PTS) system
SB45_RS18035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB45_RS18035	COG1263	PTS System
SB45_RS18050	COG3507	Belongs to the glycosyl hydrolase 43 family
SB45_RS18075	COG0010	Belongs to the arginase family
SB45_RS18080	COG0833	amino acid
SB45_RS18085	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SB45_RS18090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB45_RS18100	COG2390	Transcriptional regulator
SB45_RS18105	COG0561	phosphatase activity
SB45_RS18135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB45_RS18140	COG5294	Protein conserved in bacteria
SB45_RS18145	COG0577	efflux transmembrane transporter activity
SB45_RS18150	COG1136	(ABC) transporter
SB45_RS18155	COG2205	protein histidine kinase activity
SB45_RS18160	COG0745	RESPONSE REGULATOR receiver
SB45_RS18175	COG1082	Xylose isomerase domain protein TIM barrel
SB45_RS18185	COG2814	Major facilitator Superfamily
SB45_RS18215	COG1349	DNA-binding transcription factor activity
SB45_RS18220	COG0667	Aldo Keto reductase
SB45_RS18225	COG2814	Major facilitator Superfamily
SB45_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS18245	COG2197	response regulator
SB45_RS18250	COG4585	Histidine kinase
SB45_RS18255	COG3239	Fatty acid desaturase
SB45_RS18265	COG1309	transcriptional regulator
SB45_RS18270	COG1012	belongs to the aldehyde dehydrogenase family
SB45_RS18275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SB45_RS18285	COG0640	Transcriptional regulator
SB45_RS18290	COG2814	Major facilitator Superfamily
SB45_RS18295	COG1714	RDD family
SB45_RS18305	COG0450	alkyl hydroperoxide reductase
SB45_RS18310	COG3634	alkyl hydroperoxide reductase activity
SB45_RS18315	COG1113	amino acid transport
SB45_RS18325	COG2080	2 iron, 2 sulfur cluster binding
SB45_RS18340	COG2068	MobA-Related Protein
SB45_RS18345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SB45_RS18365	COG1192	Involved in chromosome partitioning
SB45_RS18385	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
SB45_RS18390	COG0667	Aldo Keto reductase
SB45_RS18395	COG0456	acetyltransferase
SB45_RS18400	COG0457	Tetratricopeptide repeat
SB45_RS18405	COG0010	Belongs to the arginase family
SB45_RS18410	COG0833	amino acid
SB45_RS18415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB45_RS18420	COG5658	integral membrane protein
SB45_RS18425	COG0640	Transcriptional regulator
SB45_RS18430	COG3829	transcription factor binding
SB45_RS18440	COG0488	(ABC) transporter
SB45_RS18455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB45_RS18460	COG5002	protein histidine kinase activity
SB45_RS18470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB45_RS18475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SB45_RS18480	COG4853	Protein conserved in bacteria
SB45_RS18485	COG4863	YycH protein
SB45_RS18490	COG5002	protein histidine kinase activity
SB45_RS18495	COG0745	RESPONSE REGULATOR receiver
SB45_RS18530	COG0346	lactoylglutathione lyase activity
SB45_RS18535	COG0305	Participates in initiation and elongation during chromosome replication
SB45_RS18555	COG0297	glycogen (starch) synthase activity
SB45_RS18565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SB45_RS18570	COG0438	transferase activity, transferring glycosyl groups
SB45_RS18580	COG0515	serine threonine protein kinase
SB45_RS18590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SB45_RS18595	COG4241	membrane
SB45_RS18605	COG5577	PFAM Coat F domain
SB45_RS18610	COG1733	regulation of RNA biosynthetic process
SB45_RS18620	COG0697	spore germination
SB45_RS18625	COG1621	beta-fructofuranosidase activity
SB45_RS18630	COG1621	beta-fructofuranosidase activity
SB45_RS18635	COG1802	Transcriptional regulator
SB45_RS18640	COG2318	DinB family
SB45_RS18645	COG2211	Major facilitator Superfamily
SB45_RS18655	COG0778	Nitroreductase
SB45_RS18660	COG1846	Transcriptional regulator
SB45_RS18665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB45_RS18670	COG1846	Transcriptional regulator
SB45_RS18685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SB45_RS18690	COG0583	DNA-binding transcription factor activity
SB45_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
SB45_RS18700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB45_RS18705	COG0697	spore germination
SB45_RS18725	COG1331	Highly conserved protein containing a thioredoxin domain
SB45_RS18730	COG1266	CAAX protease self-immunity
SB45_RS18735	COG2814	Major facilitator Superfamily
SB45_RS18735	COG0477	Major facilitator Superfamily
SB45_RS18740	COG0346	lactoylglutathione lyase activity
SB45_RS18745	COG1609	Transcriptional regulator
SB45_RS18750	COG0708	Exodeoxyribonuclease III
SB45_RS18755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB45_RS18760	COG2169	Transcriptional regulator
SB45_RS18770	COG0629	single-stranded DNA binding
SB45_RS18780	COG0012	GTP binding
SB45_RS18785	COG0243	molybdopterin cofactor binding
SB45_RS18790	COG4481	Protein conserved in bacteria
SB45_RS18795	COG3949	Membrane
SB45_RS18810	COG1475	DNA binding
SB45_RS18815	COG1192	Involved in chromosome partitioning
SB45_RS18840	COG1847	R3H domain protein
SB45_RS18845	COG0706	membrane insertase activity
SB45_RS18860	COG0592	DNA-directed DNA polymerase activity
SB45_RS18865	COG2501	S4 domain
SB45_RS18880	COG0187	DNA topoisomerase II activity
SB45_RS18885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB45_RS18970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SB45_RS18975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB45_RS18985	COG1054	Belongs to the UPF0176 family
SB45_RS19005	COG5583	Uncharacterized small protein (DUF2292)
SB45_RS19075	COG2721	sulfolactate sulfo-lyase activity
SB45_RS19340	COG1349	DNA-binding transcription factor activity
SB45_RS19470	COG3093	addiction module antidote protein HigA
SB45_RS19545	COG2723	6-phospho-beta-galactosidase activity