locus-tag	class	description
I8N72_RS00010	COG0592	DNA-directed DNA polymerase activity
I8N72_RS00015	COG2501	S4 domain
I8N72_RS00030	COG0187	DNA topoisomerase II activity
I8N72_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N72_RS00070	COG0517	IMP dehydrogenase activity
I8N72_RS00070	COG0516	GMP reductase activity
I8N72_RS00075	COG1686	Belongs to the peptidase S11 family
I8N72_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
I8N72_RS00105	COG1428	Deoxynucleoside kinase
I8N72_RS00110	COG1428	Deoxynucleoside kinase
I8N72_RS00115	COG3858	chitin binding
I8N72_RS00115	COG1388	LysM domain
I8N72_RS00120	COG1335	isochorismatase
I8N72_RS00125	COG0590	tRNA wobble adenosine to inosine editing
I8N72_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8N72_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I8N72_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I8N72_RS00195	COG3853	Toxic anion resistance protein (TelA)
I8N72_RS00200	COG1982	Orn Lys Arg decarboxylase major
I8N72_RS00210	COG3870	Protein conserved in bacteria
I8N72_RS00215	COG1728	Protein conserved in bacteria
I8N72_RS00220	COG0470	DNA polymerase III
I8N72_RS00225	COG1774	PSP1 C-terminal conserved region
I8N72_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I8N72_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I8N72_RS00250	COG2002	toxin-antitoxin pair type II binding
I8N72_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N72_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N72_RS00260	COG0084	hydrolase, TatD family'
I8N72_RS00265	COG3583	domain protein
I8N72_RS00265	COG3584	3D domain protein
I8N72_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N72_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8N72_RS00285	COG4466	Protein conserved in bacteria
I8N72_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N72_RS00305	COG0251	oxidation-reduction process
I8N72_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8N72_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I8N72_RS00345	COG2002	toxin-antitoxin pair type II binding
I8N72_RS00350	COG2244	polysaccharide biosynthetic process
I8N72_RS00355	COG3956	TIGRFAM MazG family protein
I8N72_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I8N72_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I8N72_RS00380	COG1098	S1 RNA binding domain
I8N72_RS00395	COG2208	phosphoserine phosphatase activity
I8N72_RS00400	COG2304	oxidoreductase activity
I8N72_RS00405	COG0515	serine threonine protein kinase
I8N72_RS00410	COG0037	tRNA processing
I8N72_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I8N72_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8N72_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N72_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N72_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N72_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
I8N72_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8N72_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8N72_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8N72_RS00475	COG1396	sequence-specific DNA binding
I8N72_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N72_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8N72_RS00565	COG4463	regulation of RNA biosynthetic process
I8N72_RS00570	COG3880	PFAM UvrB UvrC protein
I8N72_RS00580	COG0542	response to heat
I8N72_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I8N72_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I8N72_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
I8N72_RS00615	COG1045	serine acetyltransferase
I8N72_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I8N72_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N72_RS00635	COG3688	RNA-binding protein containing a PIN domain
I8N72_RS00640	COG1595	DNA-templated transcription, initiation
I8N72_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N72_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
I8N72_RS00680	COG2813	Specifically methylates the guanine in position
I8N72_RS00695	COG1358	cellular component organization or biogenesis
I8N72_RS00720	COG0596	Alpha beta hydrolase
I8N72_RS00830	COG0201	protein transport
I8N72_RS00840	COG0024	Methionine aminopeptidase
I8N72_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8N72_RS00875	COG1122	ATPase activity
I8N72_RS00880	COG1122	ATPase activity
I8N72_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N72_RS00905	COG2226	methyltransferase
I8N72_RS00910	COG2318	DinB family
I8N72_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS00925	COG0489	protein tyrosine kinase activity
I8N72_RS00935	COG2194	sulfuric ester hydrolase activity
I8N72_RS00940	COG0726	polysaccharide deacetylase
I8N72_RS01000	COG0738	Major facilitator superfamily
I8N72_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
I8N72_RS01025	COG0385	Bile acid
I8N72_RS01030	COG2819	hydrolase of the alpha beta superfamily
I8N72_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N72_RS01050	COG2207	Transcriptional regulator
I8N72_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N72_RS01055	COG3876	Protein conserved in bacteria
I8N72_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
I8N72_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N72_RS01070	COG1263	PTS System
I8N72_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N72_RS01085	COG1683	Conserved Protein
I8N72_RS01115	COG1595	DNA-templated transcription, initiation
I8N72_RS01120	COG5662	AntiSigma factor
I8N72_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N72_RS01130	COG4856	YbbR-like protein
I8N72_RS01175	COG1346	cytolysis
I8N72_RS01180	COG1380	Effector of murein hydrolase LrgA
I8N72_RS01185	COG1846	Transcriptional regulator
I8N72_RS01190	COG1113	amino acid transport
I8N72_RS01195	COG1011	Hydrolase
I8N72_RS01200	COG4585	Histidine kinase
I8N72_RS01205	COG2197	response regulator
I8N72_RS01210	COG1131	(ABC) transporter
I8N72_RS01250	COG0531	amino acid
I8N72_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
I8N72_RS01270	COG2271	Major facilitator Superfamily
I8N72_RS01280	COG2368	4-hydroxyphenylacetate
I8N72_RS01290	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS01305	COG0371	Dehydrogenase
I8N72_RS01315	COG1183	phosphatidylcholine synthase activity
I8N72_RS01320	COG0586	Pfam SNARE associated Golgi protein
I8N72_RS01325	COG0688	phosphatidylethanolamine metabolic process
I8N72_RS01340	COG1301	dicarboxylic acid transport
I8N72_RS01345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS01350	COG0833	amino acid
I8N72_RS01355	COG2040	homocysteine
I8N72_RS01360	COG1115	amino acid carrier protein
I8N72_RS01365	COG2066	Belongs to the glutaminase family
I8N72_RS01375	COG0784	Response regulator, receiver
I8N72_RS01380	COG3173	Aminoglycoside phosphotransferase
I8N72_RS01390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N72_RS01395	COG0778	Nitroreductase
I8N72_RS01400	COG0346	lactoylglutathione lyase activity
I8N72_RS01405	COG2259	Doxx family
I8N72_RS01410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS01420	COG3773	Cell wall hydrolase
I8N72_RS01425	COG3540	Alkaline phosphatase
I8N72_RS01430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N72_RS01435	COG0805	protein transport
I8N72_RS01445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N72_RS01450	COG0477	Major facilitator Superfamily
I8N72_RS01455	COG1309	transcriptional regulator
I8N72_RS01465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I8N72_RS01470	COG3012	SEC-C Motif Domain Protein
I8N72_RS01470	COG1405	negative regulation of cell septum assembly
I8N72_RS01475	COG0667	Aldo Keto reductase
I8N72_RS01485	COG1595	DNA-templated transcription, initiation
I8N72_RS01490	COG1595	DNA-templated transcription, initiation
I8N72_RS01495	COG1876	peptidase activity
I8N72_RS01500	COG0457	Tetratricopeptide repeat
I8N72_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS01510	COG0366	Alpha amylase catalytic
I8N72_RS01515	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8N72_RS01520	COG1121	(ABC) transporter
I8N72_RS01525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N72_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS01535	COG2310	stress, protein
I8N72_RS01540	COG2310	stress, protein
I8N72_RS01545	COG2310	stress, protein
I8N72_RS01550	COG0861	Integral membrane protein TerC family
I8N72_RS01560	COG3853	Toxic anion resistance protein (TelA)
I8N72_RS01565	COG0477	Major facilitator Superfamily
I8N72_RS01570	COG4175	Glycine betaine
I8N72_RS01570	COG0517	IMP dehydrogenase activity
I8N72_RS01575	COG4176	ABC-type proline glycine betaine transport system permease component
I8N72_RS01580	COG2113	Glycine betaine
I8N72_RS01585	COG1473	amidohydrolase
I8N72_RS01590	COG1288	antiporter activity
I8N72_RS01600	COG0366	Alpha amylase catalytic
I8N72_RS01610	COG2814	Major facilitator Superfamily
I8N72_RS01615	COG1846	Transcriptional regulator
I8N72_RS01620	COG1280	lysine exporter protein (LysE YggA)
I8N72_RS01625	COG3403	YqcI/YcgG family
I8N72_RS01630	COG1113	amino acid transport
I8N72_RS01635	COG3665	Urea carboxylase-associated protein
I8N72_RS01650	COG1660	Displays ATPase and GTPase activities
I8N72_RS01660	COG2271	Major facilitator Superfamily
I8N72_RS01665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8N72_RS01670	COG3458	cephalosporin-C deacetylase activity
I8N72_RS01675	COG3541	Predicted nucleotidyltransferase
I8N72_RS01680	COG0506	proline dehydrogenase activity
I8N72_RS01685	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS01690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N72_RS01695	COG2508	Transcriptional regulator
I8N72_RS01705	COG1587	Uroporphyrinogen-III synthase
I8N72_RS01705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N72_RS01710	COG2146	nitrite reductase [NAD(P)H] activity
I8N72_RS01715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N72_RS01720	COG0523	cobalamin synthesis protein
I8N72_RS01725	COG1063	alcohol dehydrogenase
I8N72_RS01730	COG1714	RDD family
I8N72_RS01755	COG3209	COG3209 Rhs family protein
I8N72_RS01760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I8N72_RS01765	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I8N72_RS01770	COG1733	regulation of RNA biosynthetic process
I8N72_RS01775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS01780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS01785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS01790	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N72_RS01805	COG2364	Membrane
I8N72_RS01810	COG1126	abc transporter atp-binding protein
I8N72_RS01815	COG0765	amino acid transport
I8N72_RS01820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS01825	COG0583	DNA-binding transcription factor activity
I8N72_RS01830	COG0163	prenyltransferase activity
I8N72_RS01835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I8N72_RS01850	COG3104	oligopeptide transport
I8N72_RS01855	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N72_RS01865	COG0697	spore germination
I8N72_RS01875	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N72_RS01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS01885	COG0456	acetyltransferase
I8N72_RS01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS01895	COG0765	amino acid transport
I8N72_RS01900	COG1126	abc transporter atp-binding protein
I8N72_RS01905	COG1473	amidohydrolase
I8N72_RS01910	COG2079	MmgE PrpD family protein
I8N72_RS01915	COG1136	(ABC) transporter
I8N72_RS01920	COG0577	efflux transmembrane transporter activity
I8N72_RS01925	COG0745	RESPONSE REGULATOR receiver
I8N72_RS01930	COG5002	protein histidine kinase activity
I8N72_RS01930	COG3850	Histidine kinase
I8N72_RS01935	COG0457	Tetratricopeptide repeat
I8N72_RS01950	COG0527	aspartate kinase activity
I8N72_RS01955	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS01960	COG4605	iron ion homeostasis
I8N72_RS01965	COG4604	ABC transporter, ATP-binding protein
I8N72_RS01970	COG4607	ABC-type enterochelin transport system periplasmic component
I8N72_RS01975	COG2814	Major facilitator Superfamily
I8N72_RS01980	COG1309	transcriptional regulator
I8N72_RS01985	COG0778	Nitroreductase
I8N72_RS01990	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N72_RS01995	COG0640	Transcriptional regulator
I8N72_RS02000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N72_RS02005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS02010	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS02015	COG4975	Glucose uptake
I8N72_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS02025	COG4549	nuclear export factor GLE1
I8N72_RS02030	COG1276	copper resistance
I8N72_RS02030	COG2372	response to copper ion
I8N72_RS02035	COG1349	DNA-binding transcription factor activity
I8N72_RS02045	COG2213	PTS system mannitol-specific
I8N72_RS02050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS02060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I8N72_RS02070	COG0561	phosphatase activity
I8N72_RS02080	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N72_RS02090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8N72_RS02095	COG1984	allophanate hydrolase subunit 2
I8N72_RS02100	COG1414	Transcriptional regulator
I8N72_RS02105	COG2755	lipolytic protein G-D-S-L family
I8N72_RS02115	COG2329	Antibiotic biosynthesis monooxygenase
I8N72_RS02120	COG0768	penicillin binding
I8N72_RS02125	COG4989	oxidoreductase activity
I8N72_RS02130	COG3711	transcriptional antiterminator
I8N72_RS02135	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS02145	COG1917	Cupin 2, conserved barrel domain protein
I8N72_RS02150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N72_RS02155	COG3871	stress protein (general stress protein 26)
I8N72_RS02165	COG2814	Major facilitator Superfamily
I8N72_RS02170	COG1522	sequence-specific DNA binding
I8N72_RS02175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N72_RS02175	COG0551	DNA topoisomerase type I activity
I8N72_RS02180	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I8N72_RS02185	COG3706	GGDEF domain
I8N72_RS02190	COG5298	Protein conserved in bacteria
I8N72_RS02195	COG1215	transferase activity, transferring glycosyl groups
I8N72_RS02205	COG0531	amino acid
I8N72_RS02210	COG0494	nUDIX hydrolase
I8N72_RS02215	COG0028	Belongs to the TPP enzyme family
I8N72_RS02235	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N72_RS02245	COG4876	unkown
I8N72_RS02255	COG2076	Multidrug Resistance protein
I8N72_RS02260	COG2217	Heavy metal translocating P-type atpase
I8N72_RS02265	COG3729	General stress protein
I8N72_RS02270	COG0662	Cupin 2, conserved barrel domain protein
I8N72_RS02275	COG2329	Antibiotic biosynthesis monooxygenase
I8N72_RS02280	COG3546	catalase activity
I8N72_RS02285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I8N72_RS02290	COG3290	protein histidine kinase activity
I8N72_RS02295	COG4565	transcriptional regulatory protein
I8N72_RS02300	COG1301	dicarboxylic acid transport
I8N72_RS02305	COG0628	permease
I8N72_RS02310	COG1131	(ABC) transporter
I8N72_RS02315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N72_RS02325	COG1960	acyl-CoA dehydrogenase activity
I8N72_RS02340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N72_RS02345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS02355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I8N72_RS02360	COG0513	Belongs to the DEAD box helicase family
I8N72_RS02365	COG3402	PFAM membrane-flanked domain
I8N72_RS02370	COG3428	Bacterial PH domain
I8N72_RS02375	COG0705	Rhomboid family
I8N72_RS02385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I8N72_RS02390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N72_RS02395	COG0864	Transcriptional regulator
I8N72_RS02400	COG2337	Toxic component of a toxin-antitoxin (TA) module
I8N72_RS02405	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS02410	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS02415	COG2172	sigma factor antagonist activity
I8N72_RS02420	COG2208	phosphoserine phosphatase activity
I8N72_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS02435	COG1191	sigma factor activity
I8N72_RS02440	COG2208	phosphoserine phosphatase activity
I8N72_RS02445	COG2183	response to ionizing radiation
I8N72_RS02530	COG5444	nuclease activity
I8N72_RS02545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N72_RS02550	COG0477	Major facilitator Superfamily
I8N72_RS02560	COG1764	response to oxidative stress
I8N72_RS02565	COG1846	Transcriptional regulator
I8N72_RS02575	COG2030	dehydratase
I8N72_RS02585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8N72_RS02590	COG1959	2 iron, 2 sulfur cluster binding
I8N72_RS02595	COG2910	NAD(P)H-binding
I8N72_RS02600	COG1278	Cold shock
I8N72_RS02610	COG1937	Protein conserved in bacteria
I8N72_RS02615	COG2210	Belongs to the sulfur carrier protein TusA family
I8N72_RS02620	COG1054	Belongs to the UPF0176 family
I8N72_RS02625	COG0425	Belongs to the sulfur carrier protein TusA family
I8N72_RS02625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N72_RS02630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N72_RS02630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS02635	COG0425	Belongs to the sulfur carrier protein TusA family
I8N72_RS02640	COG0730	response to heat
I8N72_RS02650	COG1794	racemase activity, acting on amino acids and derivatives
I8N72_RS02665	COG3621	Patatin-like phospholipase
I8N72_RS02675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8N72_RS02680	COG1802	Transcriptional regulator
I8N72_RS02685	COG0251	oxidation-reduction process
I8N72_RS02690	COG0814	amino acid
I8N72_RS02695	COG1473	amidohydrolase
I8N72_RS02700	COG1917	Cupin 2, conserved barrel domain protein
I8N72_RS02700	COG2207	Transcriptional regulator
I8N72_RS02710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N72_RS02715	COG0477	Major facilitator Superfamily
I8N72_RS02735	COG0277	FAD linked oxidase domain protein
I8N72_RS02765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8N72_RS02790	COG1064	alcohol dehydrogenase
I8N72_RS02795	COG0789	Transcriptional regulator
I8N72_RS02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N72_RS02815	COG2814	Major facilitator Superfamily
I8N72_RS02820	COG1309	transcriptional regulator
I8N72_RS02825	COG5577	PFAM Coat F domain
I8N72_RS02835	COG1063	alcohol dehydrogenase
I8N72_RS02840	COG5577	PFAM Coat F domain
I8N72_RS02850	COG4585	Histidine kinase
I8N72_RS02855	COG2197	response regulator
I8N72_RS02860	COG2409	Drug exporters of the RND superfamily
I8N72_RS02865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I8N72_RS02870	COG0488	(ABC) transporter
I8N72_RS02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N72_RS02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS02890	COG2814	Major facilitator Superfamily
I8N72_RS02895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N72_RS02905	COG0730	response to heat
I8N72_RS02910	COG0456	acetyltransferase
I8N72_RS02915	COG0789	Transcriptional regulator
I8N72_RS02915	COG4978	Transcriptional regulator
I8N72_RS02920	COG0697	spore germination
I8N72_RS02925	COG1051	belongs to the nudix hydrolase family
I8N72_RS02930	COG0596	Alpha beta hydrolase
I8N72_RS02935	COG0473	3-isopropylmalate dehydrogenase activity
I8N72_RS02940	COG1802	Transcriptional regulator
I8N72_RS02945	COG1819	glycosyl
I8N72_RS02970	COG1388	LysM domain
I8N72_RS02975	COG2814	Major facilitator Superfamily
I8N72_RS02980	COG2188	Transcriptional regulator
I8N72_RS02985	COG2186	Transcriptional regulator
I8N72_RS02990	COG2807	transmembrane transport
I8N72_RS02995	COG2076	Multidrug Resistance protein
I8N72_RS03000	COG2076	Multidrug Resistance protein
I8N72_RS03005	COG1309	transcriptional regulator
I8N72_RS03010	COG0531	amino acid
I8N72_RS03020	COG3832	glyoxalase III activity
I8N72_RS03025	COG0604	alcohol dehydrogenase
I8N72_RS03030	COG2814	Major facilitator Superfamily
I8N72_RS03070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8N72_RS03075	COG0802	atpase or kinase
I8N72_RS03080	COG1214	PFAM Peptidase M22, glycoprotease
I8N72_RS03085	COG0456	acetyltransferase
I8N72_RS03090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8N72_RS03095	COG0488	(ABC) transporter
I8N72_RS03110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N72_RS03115	COG0805	protein transport
I8N72_RS03125	COG1266	CAAX protease self-immunity
I8N72_RS03140	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS03155	COG0457	Tetratricopeptide repeat
I8N72_RS03160	COG1063	alcohol dehydrogenase
I8N72_RS03165	COG2211	Major facilitator Superfamily
I8N72_RS03170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N72_RS03180	COG1842	Phage shock protein A
I8N72_RS03185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N72_RS03190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I8N72_RS03195	COG4260	virion core protein, lumpy skin disease virus
I8N72_RS03200	COG2755	lipolytic protein G-D-S-L family
I8N72_RS03200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8N72_RS03210	COG1595	DNA-templated transcription, initiation
I8N72_RS03215	COG1063	alcohol dehydrogenase
I8N72_RS03220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I8N72_RS03225	COG0823	Involved in the tonB-independent uptake of proteins
I8N72_RS03240	COG2132	Multicopper oxidase
I8N72_RS03245	COG1113	amino acid transport
I8N72_RS03250	COG0714	Associated with various cellular activities
I8N72_RS03255	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I8N72_RS03260	COG1305	Transglutaminase-like
I8N72_RS03280	COG2252	PERMEase
I8N72_RS03285	COG3064	Membrane
I8N72_RS03305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I8N72_RS03310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I8N72_RS03315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8N72_RS03320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8N72_RS03325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8N72_RS03340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I8N72_RS03350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I8N72_RS03355	COG0138	bifunctional purine biosynthesis protein purh
I8N72_RS03360	COG0151	Belongs to the GarS family
I8N72_RS03370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8N72_RS03375	COG1470	cell adhesion involved in biofilm formation
I8N72_RS03380	COG4496	protein, YerC YecD
I8N72_RS03385	COG0069	glutamate synthase activity
I8N72_RS03395	COG0210	DNA helicase
I8N72_RS03405	COG4851	CamS sex pheromone cAM373 precursor
I8N72_RS03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N72_RS03415	COG1285	pathogenesis
I8N72_RS03420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N72_RS03440	COG1309	transcriptional regulator
I8N72_RS03445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8N72_RS03450	COG1597	lipid kinase activity
I8N72_RS03455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N72_RS03465	COG1131	(ABC) transporter
I8N72_RS03490	COG5444	nuclease activity
I8N72_RS03525	COG3546	catalase activity
I8N72_RS03530	COG0454	-acetyltransferase
I8N72_RS03540	COG2323	membrane
I8N72_RS03545	COG2329	Antibiotic biosynthesis monooxygenase
I8N72_RS03550	COG0346	lactoylglutathione lyase activity
I8N72_RS03555	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS03560	COG5583	Uncharacterized small protein (DUF2292)
I8N72_RS03565	COG0196	riboflavin kinase activity
I8N72_RS03570	COG0670	Belongs to the BI1 family
I8N72_RS03575	COG1846	Transcriptional regulator
I8N72_RS03580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N72_RS03590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N72_RS03590	COG2124	cytochrome p450
I8N72_RS03595	COG1368	sulfuric ester hydrolase activity
I8N72_RS03600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8N72_RS03605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS03610	COG1442	glycosyl transferase family 8
I8N72_RS03615	COG1216	Glycosyl transferase, family 2
I8N72_RS03620	COG1442	glycosyl transferase family 8
I8N72_RS03625	COG2223	nitrite transmembrane transporter activity
I8N72_RS03630	COG0531	amino acid
I8N72_RS03635	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS03640	COG0840	transmembrane signaling receptor activity
I8N72_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS03650	COG0457	Tetratricopeptide repeat
I8N72_RS03650	COG0463	Glycosyl transferase, family 2
I8N72_RS03655	COG0488	(ABC) transporter
I8N72_RS03660	COG0789	Transcriptional regulator
I8N72_RS03665	COG2814	Major facilitator Superfamily
I8N72_RS03670	COG0488	(ABC) transporter
I8N72_RS03675	COG0513	Belongs to the DEAD box helicase family
I8N72_RS03685	COG2130	NADP-dependent
I8N72_RS03700	COG3866	Pectate lyase
I8N72_RS03705	COG0471	metal ion transport
I8N72_RS03720	COG2972	Histidine kinase
I8N72_RS03720	COG0745	RESPONSE REGULATOR receiver
I8N72_RS03725	COG3279	Response regulator of the LytR AlgR family
I8N72_RS03735	COG3764	Sortase (surface protein transpeptidase)
I8N72_RS03740	COG3290	protein histidine kinase activity
I8N72_RS03745	COG4565	transcriptional regulatory protein
I8N72_RS03750	COG3181	Tripartite tricarboxylate transporter family receptor
I8N72_RS03755	COG2851	Citrate transporter
I8N72_RS03760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS03765	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I8N72_RS03775	COG2258	MOSC domain
I8N72_RS03795	COG0024	Methionine aminopeptidase
I8N72_RS03800	COG1263	PTS System
I8N72_RS03800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS03810	COG1368	sulfuric ester hydrolase activity
I8N72_RS03820	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N72_RS03835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS03835	COG1263	PTS System
I8N72_RS03840	COG0366	Alpha amylase catalytic
I8N72_RS03845	COG2188	Transcriptional regulator
I8N72_RS03850	COG0778	Nitroreductase
I8N72_RS03865	COG0737	Belongs to the 5'-nucleotidase family
I8N72_RS03870	COG0693	protein deglycase activity
I8N72_RS03875	COG1609	Transcriptional regulator
I8N72_RS03890	COG2814	Major facilitator Superfamily
I8N72_RS03900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N72_RS03905	COG4980	gas vesicle protein
I8N72_RS03910	COG1295	ribonuclease BN
I8N72_RS03915	COG0477	Major facilitator Superfamily
I8N72_RS03920	COG0387	Pfam Sodium calcium exchanger
I8N72_RS03930	COG0668	transmembrane transport
I8N72_RS03935	COG0535	radical SAM domain protein
I8N72_RS03945	COG0726	polysaccharide deacetylase
I8N72_RS03950	COG2084	Dehydrogenase
I8N72_RS03960	COG0598	Magnesium transport protein CorA
I8N72_RS03965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I8N72_RS03970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N72_RS03980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N72_RS03985	COG4637	Psort location Cytoplasmic, score
I8N72_RS03990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N72_RS03995	COG0022	dehydrogenase e1 component
I8N72_RS04000	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N72_RS04005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N72_RS04010	COG3284	Transcriptional regulator
I8N72_RS04020	COG1486	melibiose metabolic process
I8N72_RS04025	COG1737	Transcriptional regulator
I8N72_RS04030	COG1263	PTS System
I8N72_RS04030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS04035	COG1132	(ABC) transporter
I8N72_RS04040	COG1132	(ABC) transporter
I8N72_RS04045	COG2259	Doxx family
I8N72_RS04050	COG2514	catechol 2,3-dioxygenase activity
I8N72_RS04060	COG1695	Transcriptional regulator
I8N72_RS04065	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N72_RS04070	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I8N72_RS04075	COG0574	Belongs to the PEP-utilizing enzyme family
I8N72_RS04075	COG3848	Pyruvate phosphate dikinase
I8N72_RS04080	COG2732	(Barnase) inhibitor
I8N72_RS04085	COG2318	DinB family
I8N72_RS04090	COG2814	Major facilitator Superfamily
I8N72_RS04095	COG1846	Transcriptional regulator
I8N72_RS04100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I8N72_RS04100	COG0392	lysyltransferase activity
I8N72_RS04105	COG0384	phenazine biosynthesis protein PhzF
I8N72_RS04110	COG0778	Nitroreductase
I8N72_RS04125	COG1090	epimerase
I8N72_RS04140	COG2814	Major facilitator Superfamily
I8N72_RS04150	COG3591	Belongs to the peptidase S1B family
I8N72_RS04165	COG3103	Sh3 type 3 domain protein
I8N72_RS04170	COG5658	integral membrane protein
I8N72_RS04175	COG0596	Alpha beta hydrolase
I8N72_RS04180	COG0463	Glycosyl transferase, family 2
I8N72_RS04185	COG4485	Bacterial membrane protein, YfhO
I8N72_RS04190	COG1988	membrane-bound metal-dependent
I8N72_RS04195	COG1194	a g-specific adenine glycosylase
I8N72_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS04225	COG1132	(ABC) transporter
I8N72_RS04230	COG4129	membrane
I8N72_RS04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I8N72_RS04245	COG0735	belongs to the Fur family
I8N72_RS04360	COG3340	Belongs to the peptidase S51 family
I8N72_RS04370	COG0277	FAD linked oxidase domain protein
I8N72_RS04380	COG0747	negative chemotaxis
I8N72_RS04385	COG0601	transmembrane transport
I8N72_RS04390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N72_RS04395	COG0444	Belongs to the ABC transporter superfamily
I8N72_RS04400	COG4608	Belongs to the ABC transporter superfamily
I8N72_RS04405	COG0753	catalase activity
I8N72_RS04415	COG1116	anion transmembrane transporter activity
I8N72_RS04420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N72_RS04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N72_RS04445	COG1476	TRANSCRIPTIONal
I8N72_RS04455	COG3382	B3 4 domain protein
I8N72_RS04460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I8N72_RS04470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I8N72_RS04475	COG0789	Transcriptional regulator
I8N72_RS04480	COG1664	Polymer-forming cytoskeletal
I8N72_RS04485	COG1664	Polymer-forming cytoskeletal
I8N72_RS04490	COG2766	serine protein kinase
I8N72_RS04500	COG1846	Transcriptional regulator
I8N72_RS04505	COG1566	PFAM secretion protein HlyD family protein
I8N72_RS04510	COG2814	Major facilitator Superfamily
I8N72_RS04515	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N72_RS04530	COG1725	Transcriptional regulator
I8N72_RS04535	COG1131	(ABC) transporter
I8N72_RS04540	COG1131	(ABC) transporter
I8N72_RS04545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N72_RS04550	COG1278	Cold shock
I8N72_RS04555	COG1464	Belongs to the NlpA lipoprotein family
I8N72_RS04560	COG3706	GGDEF domain
I8N72_RS04565	COG1823	symporter activity
I8N72_RS04585	COG5577	PFAM Coat F domain
I8N72_RS04590	COG4085	toxin activity
I8N72_RS04590	COG0737	Belongs to the 5'-nucleotidase family
I8N72_RS04590	COG1525	nuclease
I8N72_RS04595	COG3764	Sortase (surface protein transpeptidase)
I8N72_RS04600	COG0564	pseudouridine synthase activity
I8N72_RS04610	COG0517	IMP dehydrogenase activity
I8N72_RS04615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8N72_RS04620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N72_RS04620	COG3153	acetyltransferase
I8N72_RS04625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N72_RS04630	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I8N72_RS04635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8N72_RS04645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8N72_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8N72_RS04655	COG4585	Histidine kinase
I8N72_RS04655	COG2203	Gaf domain
I8N72_RS04660	COG2197	response regulator
I8N72_RS04665	COG0431	NADPH-dependent FMN reductase
I8N72_RS04680	COG1388	LysM domain
I8N72_RS04680	COG0791	NLP P60 protein
I8N72_RS04685	COG1959	2 iron, 2 sulfur cluster binding
I8N72_RS04690	COG0668	transmembrane transport
I8N72_RS04695	COG2719	SpoVR family
I8N72_RS04700	COG1785	Belongs to the alkaline phosphatase family
I8N72_RS04705	COG1388	LysM domain
I8N72_RS04705	COG0791	NLP P60 protein
I8N72_RS04710	COG0583	DNA-binding transcription factor activity
I8N72_RS04715	COG0372	Belongs to the citrate synthase family
I8N72_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS04725	COG0531	amino acid
I8N72_RS04730	COG0733	neurotransmitter:sodium symporter activity
I8N72_RS04745	COG1595	DNA-templated transcription, initiation
I8N72_RS04750	COG0204	Acyl-transferase
I8N72_RS04755	COG1253	flavin adenine dinucleotide binding
I8N72_RS04760	COG0789	Transcriptional regulator
I8N72_RS04765	COG0436	Aminotransferase
I8N72_RS04770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N72_RS04775	COG1253	flavin adenine dinucleotide binding
I8N72_RS04780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N72_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N72_RS04790	COG0584	glycerophosphoryl diester phosphodiesterase
I8N72_RS04800	COG0668	transmembrane transport
I8N72_RS04805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8N72_RS04810	COG0726	polysaccharide deacetylase
I8N72_RS04815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS04820	COG3226	Transcriptional regulator
I8N72_RS04830	COG0589	response to stress
I8N72_RS04835	COG1132	(ABC) transporter
I8N72_RS04840	COG1132	(ABC) transporter
I8N72_RS04845	COG0702	epimerase
I8N72_RS04860	COG0189	ligase activity
I8N72_RS04865	COG0189	ligase activity
I8N72_RS04880	COG4335	DNA alkylation repair
I8N72_RS04885	COG0561	phosphatase activity
I8N72_RS04890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N72_RS04900	COG0475	glutathione-regulated potassium exporter activity
I8N72_RS04905	COG0490	domain, Protein
I8N72_RS04915	COG1024	Enoyl-CoA hydratase
I8N72_RS04925	COG4152	abc transporter atp-binding protein
I8N72_RS04930	COG1668	transmembrane transport
I8N72_RS04935	COG0420	3'-5' exonuclease activity
I8N72_RS04940	COG4717	serine-type aminopeptidase activity
I8N72_RS04955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N72_RS04990	COG4980	gas vesicle protein
I8N72_RS05005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I8N72_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
I8N72_RS05015	COG1131	(ABC) transporter
I8N72_RS05020	COG4473	ABC transporter
I8N72_RS05030	COG1473	amidohydrolase
I8N72_RS05035	COG3069	C4-dicarboxylate transmembrane transporter activity
I8N72_RS05040	COG2329	Antibiotic biosynthesis monooxygenase
I8N72_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N72_RS05055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8N72_RS05060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I8N72_RS05065	COG1309	transcriptional regulator
I8N72_RS05070	COG1511	domain protein
I8N72_RS05075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N72_RS05085	COG1363	Peptidase, m42
I8N72_RS05090	COG1301	dicarboxylic acid transport
I8N72_RS05100	COG1234	tRNA 3'-trailer cleavage
I8N72_RS05105	COG0095	Lipoate-protein ligase
I8N72_RS05110	COG0702	epimerase
I8N72_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS05125	COG0501	Belongs to the peptidase M48B family
I8N72_RS05130	COG1404	Belongs to the peptidase S8 family
I8N72_RS05135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8N72_RS05140	COG0406	alpha-ribazole phosphatase activity
I8N72_RS05145	COG0183	Belongs to the thiolase family
I8N72_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS05155	COG1268	BioY protein
I8N72_RS05160	COG0840	transmembrane signaling receptor activity
I8N72_RS05165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N72_RS05165	COG0723	plastoquinol--plastocyanin reductase activity
I8N72_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS05180	COG4903	ComK protein
I8N72_RS05190	COG5646	InterPro IPR014922
I8N72_RS05210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N72_RS05225	COG0398	Pfam SNARE associated Golgi protein
I8N72_RS05230	COG0681	Belongs to the peptidase S26 family
I8N72_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N72_RS05240	COG1846	Transcriptional regulator
I8N72_RS05245	COG3180	Ammonia monooxygenase
I8N72_RS05250	COG2814	Major facilitator Superfamily
I8N72_RS05260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I8N72_RS05265	COG2323	membrane
I8N72_RS05280	COG0420	3'-5' exonuclease activity
I8N72_RS05285	COG0419	ATPase involved in DNA repair
I8N72_RS05290	COG1403	HNH endonuclease
I8N72_RS05330	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8N72_RS05345	COG0367	asparagine synthase
I8N72_RS05350	COG1562	ergosterol biosynthetic process
I8N72_RS05355	COG0534	Mate efflux family protein
I8N72_RS05360	COG2207	Transcriptional regulator
I8N72_RS05360	COG1917	Cupin 2, conserved barrel domain protein
I8N72_RS05365	COG1609	Transcriptional regulator
I8N72_RS05370	COG0673	inositol 2-dehydrogenase activity
I8N72_RS05375	COG2318	DinB family
I8N72_RS05380	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N72_RS05385	COG2153	protein acetylation
I8N72_RS05390	COG0646	methionine synthase
I8N72_RS05390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I8N72_RS05400	COG2996	Protein conserved in bacteria
I8N72_RS05405	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N72_RS05410	COG0840	transmembrane signaling receptor activity
I8N72_RS05420	COG1307	EDD domain protein, DegV family
I8N72_RS05425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS05445	COG0561	phosphatase activity
I8N72_RS05450	COG1073	alpha beta
I8N72_RS05455	COG2151	metal-sulfur cluster biosynthetic enzyme
I8N72_RS05465	COG0277	FAD linked oxidase domain protein
I8N72_RS05470	COG2271	Major facilitator Superfamily
I8N72_RS05480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8N72_RS05490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N72_RS05495	COG0505	Belongs to the CarA family
I8N72_RS05500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N72_RS05505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8N72_RS05520	COG2267	carboxylic ester hydrolase activity
I8N72_RS05530	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N72_RS05545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N72_RS05550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N72_RS05555	COG5504	Zn-dependent protease
I8N72_RS05560	COG0444	Belongs to the ABC transporter superfamily
I8N72_RS05565	COG4608	Belongs to the ABC transporter superfamily
I8N72_RS05575	COG0601	transmembrane transport
I8N72_RS05580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N72_RS05590	COG0180	Tryptophanyl-tRNA synthetase
I8N72_RS05595	COG4166	transmembrane transport
I8N72_RS05600	COG0601	transmembrane transport
I8N72_RS05605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N72_RS05610	COG0444	Belongs to the ABC transporter superfamily
I8N72_RS05615	COG4608	Belongs to the ABC transporter superfamily
I8N72_RS05625	COG0456	acetyltransferase
I8N72_RS05630	COG1393	Belongs to the ArsC family
I8N72_RS05635	COG0861	Integral membrane protein TerC family
I8N72_RS05645	COG4862	establishment of competence for transformation
I8N72_RS05650	COG4469	Competence protein
I8N72_RS05655	COG1164	Oligoendopeptidase f
I8N72_RS05665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N72_RS05670	COG2346	COG2346, Truncated hemoglobins
I8N72_RS05675	COG0741	lytic transglycosylase activity
I8N72_RS05680	COG4116	CYTH
I8N72_RS05690	COG2357	RelA SpoT domain protein
I8N72_RS05695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N72_RS05700	COG0564	pseudouridine synthase activity
I8N72_RS05710	COG0569	domain protein
I8N72_RS05710	COG0475	glutathione-regulated potassium exporter activity
I8N72_RS05715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8N72_RS05720	COG0352	thiamine-phosphate diphosphorylase activity
I8N72_RS05725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N72_RS05730	COG2104	thiamine diphosphate biosynthetic process
I8N72_RS05740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N72_RS05745	COG0351	phosphomethylpyrimidine kinase
I8N72_RS05750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8N72_RS05805	COG0210	DNA helicase
I8N72_RS05825	COG1131	(ABC) transporter
I8N72_RS05835	COG2153	protein acetylation
I8N72_RS05845	COG2382	esterase
I8N72_RS05850	COG0626	cystathionine gamma-synthase activity
I8N72_RS05855	COG0626	cystathionine gamma-synthase activity
I8N72_RS05865	COG0582	viral genome integration into host DNA
I8N72_RS05870	COG2856	Zn peptidase
I8N72_RS05880	COG3620	sequence-specific DNA binding
I8N72_RS05935	COG3935	DnaD domain protein
I8N72_RS05940	COG1484	DNA-dependent DNA replication
I8N72_RS05950	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I8N72_RS05985	COG1595	DNA-templated transcription, initiation
I8N72_RS06010	COG5484	DNA packaging
I8N72_RS06125	COG4824	toxin secretion phage lysis holin
I8N72_RS06130	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS06130	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS06130	COG1388	LysM domain
I8N72_RS06160	COG5444	nuclease activity
I8N72_RS06170	COG0346	lactoylglutathione lyase activity
I8N72_RS06175	COG2367	Beta-lactamase
I8N72_RS06180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N72_RS06190	COG1846	Transcriptional regulator
I8N72_RS06200	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N72_RS06205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N72_RS06210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N72_RS06215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS06215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS06220	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N72_RS06230	COG1349	DNA-binding transcription factor activity
I8N72_RS06245	COG1846	Transcriptional regulator
I8N72_RS06250	COG1285	pathogenesis
I8N72_RS06260	COG2205	protein histidine kinase activity
I8N72_RS06270	COG3383	formate dehydrogenase (NAD+) activity
I8N72_RS06275	COG2427	Protein of unknown function (DUF1641)
I8N72_RS06280	COG2124	cytochrome p450
I8N72_RS06285	COG1819	glycosyl
I8N72_RS06295	COG1587	Uroporphyrinogen-III synthase
I8N72_RS06300	COG0390	transport system, permease component
I8N72_RS06305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N72_RS06310	COG0697	spore germination
I8N72_RS06315	COG4297	protein containing double-stranded beta helix domain
I8N72_RS06325	COG1252	NADH dehydrogenase
I8N72_RS06335	COG2211	Major facilitator Superfamily
I8N72_RS06340	COG1609	Transcriptional regulator
I8N72_RS06345	COG0246	Mannitol dehydrogenase
I8N72_RS06350	COG2721	sulfolactate sulfo-lyase activity
I8N72_RS06355	COG0745	RESPONSE REGULATOR receiver
I8N72_RS06360	COG2770	Histidine kinase
I8N72_RS06360	COG2205	protein histidine kinase activity
I8N72_RS06380	COG4585	Histidine kinase
I8N72_RS06385	COG2197	response regulator
I8N72_RS06420	COG0730	response to heat
I8N72_RS06425	COG2318	DinB family
I8N72_RS06430	COG0457	Tetratricopeptide repeat
I8N72_RS06440	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS06440	COG1388	LysM domain
I8N72_RS06440	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS06450	COG4195	phage-related replication protein
I8N72_RS06460	COG2856	Zn peptidase
I8N72_RS06465	COG1396	sequence-specific DNA binding
I8N72_RS06475	COG1522	sequence-specific DNA binding
I8N72_RS06480	COG1484	DNA-dependent DNA replication
I8N72_RS06500	COG1595	DNA-templated transcription, initiation
I8N72_RS06505	COG3728	DNA packaging
I8N72_RS06505	COG5484	DNA packaging
I8N72_RS06510	COG1783	phage Terminase large subunit
I8N72_RS06515	COG5518	Phage portal protein
I8N72_RS06520	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I8N72_RS06525	COG4653	Phage capsid family
I8N72_RS06575	COG5412	phage tail tape measure protein
I8N72_RS06575	COG3953	SLT domain
I8N72_RS06575	COG5412	phage tail tape measure protein
I8N72_RS06575	COG5412	phage tail tape measure protein
I8N72_RS06575	COG3953	SLT domain
I8N72_RS06575	COG3953	SLT domain
I8N72_RS06580	COG1652	LysM domain
I8N72_RS06585	COG4193	domain, Protein
I8N72_RS06595	COG3628	GPW Gp25 family protein
I8N72_RS06600	COG3299	homolog of phage Mu protein gp47
I8N72_RS06605	COG3778	Protein conserved in bacteria
I8N72_RS06645	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS06645	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS06660	COG0306	phosphate transporter
I8N72_RS06665	COG1392	Phosphate transport regulator
I8N72_RS06670	COG0531	amino acid
I8N72_RS06675	COG0346	lactoylglutathione lyase activity
I8N72_RS06680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N72_RS06685	COG0463	Glycosyl transferase, family 2
I8N72_RS06695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N72_RS06700	COG0477	Major facilitator Superfamily
I8N72_RS06705	COG2362	D-Aminopeptidase
I8N72_RS06710	COG0601	transmembrane transport
I8N72_RS06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N72_RS06720	COG0444	Belongs to the ABC transporter superfamily
I8N72_RS06725	COG4166	transmembrane transport
I8N72_RS06730	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N72_RS06735	COG4948	Mandelate Racemase Muconate Lactonizing
I8N72_RS06740	COG0791	NLP P60 protein
I8N72_RS06745	COG4608	Belongs to the ABC transporter superfamily
I8N72_RS06750	COG2706	6-phosphogluconolactonase activity
I8N72_RS06755	COG1834	amidinotransferase
I8N72_RS06760	COG1607	acyl-coa hydrolase
I8N72_RS06765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N72_RS06770	COG2076	Multidrug Resistance protein
I8N72_RS06775	COG2076	Multidrug Resistance protein
I8N72_RS06780	COG0788	formyltetrahydrofolate deformylase activity
I8N72_RS06785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N72_RS06795	COG1764	response to oxidative stress
I8N72_RS06800	COG1846	Transcriptional regulator
I8N72_RS06805	COG1764	response to oxidative stress
I8N72_RS06820	COG0457	Tetratricopeptide repeat
I8N72_RS06820	COG0463	Glycosyl transferase, family 2
I8N72_RS06830	COG2814	Major facilitator Superfamily
I8N72_RS06835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N72_RS06845	COG1404	Belongs to the peptidase S8 family
I8N72_RS06850	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS06855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N72_RS06860	COG1122	ATPase activity
I8N72_RS06865	COG4721	ABC-type cobalt transport system, permease component
I8N72_RS06870	COG1388	LysM domain
I8N72_RS06870	COG3858	chitin binding
I8N72_RS06880	COG2239	Acts as a magnesium transporter
I8N72_RS06885	COG0789	Transcriptional regulator
I8N72_RS06900	COG1846	Transcriptional regulator
I8N72_RS06905	COG0726	polysaccharide deacetylase
I8N72_RS06910	COG1793	dna ligase
I8N72_RS06910	COG3285	dna ligase
I8N72_RS06915	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8N72_RS06920	COG0586	Pfam SNARE associated Golgi protein
I8N72_RS06925	COG0861	Integral membrane protein TerC family
I8N72_RS06930	COG1191	sigma factor activity
I8N72_RS06955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8N72_RS06960	COG2323	membrane
I8N72_RS06970	COG3594	Acyltransferase
I8N72_RS06975	COG5002	protein histidine kinase activity
I8N72_RS06980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N72_RS06995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N72_RS07000	COG0436	Aminotransferase
I8N72_RS07030	COG3852	Histidine kinase
I8N72_RS07035	COG1846	Transcriptional regulator
I8N72_RS07040	COG1360	Flagellar Motor Protein
I8N72_RS07045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N72_RS07050	COG0542	response to heat
I8N72_RS07055	COG3949	Membrane
I8N72_RS07070	COG0720	synthase
I8N72_RS07075	COG0602	queuosine metabolic process
I8N72_RS07090	COG4873	Protein conserved in bacteria
I8N72_RS07100	COG3773	Cell wall hydrolase
I8N72_RS07105	COG2244	polysaccharide biosynthetic process
I8N72_RS07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS07115	COG2217	Heavy metal translocating P-type atpase
I8N72_RS07120	COG0006	proline dipeptidase activity
I8N72_RS07125	COG1609	Transcriptional regulator
I8N72_RS07130	COG3711	transcriptional antiterminator
I8N72_RS07135	COG1263	PTS System
I8N72_RS07135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS07135	COG2190	(PTS) system
I8N72_RS07140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS07145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8N72_RS07155	COG1533	DNA photolyase activity
I8N72_RS07160	COG0840	transmembrane signaling receptor activity
I8N72_RS07165	COG2084	Dehydrogenase
I8N72_RS07175	COG0347	Belongs to the P(II) protein family
I8N72_RS07180	COG2340	Cysteine-rich secretory protein family
I8N72_RS07185	COG0768	penicillin binding
I8N72_RS07190	COG4191	Histidine kinase
I8N72_RS07195	COG0436	Aminotransferase
I8N72_RS07205	COG0835	chemotaxis
I8N72_RS07205	COG0784	Response regulator, receiver
I8N72_RS07215	COG2814	Major facilitator Superfamily
I8N72_RS07220	COG1376	ErfK ybiS ycfS ynhG family protein
I8N72_RS07225	COG1408	metallophosphoesterase
I8N72_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS07240	COG2200	EAL domain
I8N72_RS07245	COG4703	Protein of unknown function (DUF1797)
I8N72_RS07250	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I8N72_RS07260	COG0517	IMP dehydrogenase activity
I8N72_RS07265	COG0583	DNA-binding transcription factor activity
I8N72_RS07270	COG0716	FMN binding
I8N72_RS07280	COG0716	FMN binding
I8N72_RS07300	COG0668	transmembrane transport
I8N72_RS07305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS07325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N72_RS07330	COG0303	'Molybdopterin
I8N72_RS07335	COG1763	Mo-molybdopterin cofactor biosynthetic process
I8N72_RS07340	COG0314	molybdopterin synthase activity
I8N72_RS07345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I8N72_RS07355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8N72_RS07360	COG1136	(ABC) transporter
I8N72_RS07365	COG0577	efflux transmembrane transporter activity
I8N72_RS07370	COG1349	DNA-binding transcription factor activity
I8N72_RS07375	COG1105	Belongs to the carbohydrate kinase PfkB family
I8N72_RS07380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N72_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS07380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N72_RS07385	COG0681	Belongs to the peptidase S26 family
I8N72_RS07395	COG0488	(ABC) transporter
I8N72_RS07400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N72_RS07405	COG2309	aminopeptidase activity
I8N72_RS07415	COG1077	Cell shape determining protein MreB Mrl
I8N72_RS07420	COG2002	toxin-antitoxin pair type II binding
I8N72_RS07425	COG3852	Histidine kinase
I8N72_RS07430	COG2105	PFAM AIG2 family protein
I8N72_RS07430	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I8N72_RS07435	COG0569	domain protein
I8N72_RS07445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N72_RS07455	COG0561	phosphatase activity
I8N72_RS07460	COG0242	peptide deformylase activity
I8N72_RS07470	COG0497	DNA recombination
I8N72_RS07480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS07480	COG4221	oxidoreductase activity
I8N72_RS07480	COG3321	synthase
I8N72_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS07485	COG3321	synthase
I8N72_RS07485	COG0300	oxidoreductase activity
I8N72_RS07485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS07485	COG4221	oxidoreductase activity
I8N72_RS07490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS07490	COG3321	synthase
I8N72_RS07490	COG4221	oxidoreductase activity
I8N72_RS07495	COG0300	oxidoreductase activity
I8N72_RS07495	COG3321	synthase
I8N72_RS07495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS07495	COG4221	oxidoreductase activity
I8N72_RS07500	COG3321	synthase
I8N72_RS07500	COG4221	oxidoreductase activity
I8N72_RS07500	COG0300	oxidoreductase activity
I8N72_RS07500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS07505	COG3321	synthase
I8N72_RS07505	COG0300	oxidoreductase activity
I8N72_RS07505	COG4221	oxidoreductase activity
I8N72_RS07505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS07510	COG4221	oxidoreductase activity
I8N72_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS07510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS07510	COG3321	synthase
I8N72_RS07515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N72_RS07520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N72_RS07525	COG0022	dehydrogenase e1 component
I8N72_RS07530	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N72_RS07535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N72_RS07540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS07555	COG1982	Orn Lys Arg decarboxylase major
I8N72_RS07575	COG0483	inositol monophosphate 1-phosphatase activity
I8N72_RS07585	COG3227	Zinc metalloprotease (Elastase)
I8N72_RS07605	COG1217	gtp-binding protein TYPA
I8N72_RS07615	COG4896	Protein conserved in bacteria
I8N72_RS07625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8N72_RS07630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N72_RS07635	COG2066	Belongs to the glutaminase family
I8N72_RS07645	COG0772	Belongs to the SEDS family
I8N72_RS07650	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I8N72_RS07665	COG2010	Cytochrome c
I8N72_RS07665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N72_RS07670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N72_RS07675	COG1845	cytochrome c oxidase, subunit III
I8N72_RS07680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8N72_RS07685	COG3336	cytochrome c oxidase
I8N72_RS07695	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I8N72_RS07700	COG2340	Cysteine-rich secretory protein family
I8N72_RS07715	COG3679	Belongs to the UPF0342 family
I8N72_RS07730	COG0742	ribosomal rna small subunit methyltransferase
I8N72_RS07740	COG3314	Sporulation integral membrane protein YlbJ
I8N72_RS07745	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N72_RS07750	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8N72_RS07760	COG1399	metal-binding, possibly nucleic acid-binding protein
I8N72_RS07780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N72_RS07800	COG4839	cell division protein FtsL
I8N72_RS07805	COG0768	penicillin binding
I8N72_RS07810	COG0768	penicillin binding
I8N72_RS07830	COG0772	Belongs to the SEDS family
I8N72_RS07845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8N72_RS07850	COG0849	cell division
I8N72_RS07855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8N72_RS07860	COG4412	M6 family metalloprotease domain protein
I8N72_RS07860	COG1404	Belongs to the peptidase S8 family
I8N72_RS07870	COG1191	sigma factor activity
I8N72_RS07875	COG1191	sigma factor activity
I8N72_RS07880	COG1119	ATPase activity
I8N72_RS07885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N72_RS07890	COG1873	PFAM PRC-barrel domain
I8N72_RS07895	COG1496	oxidoreductase activity
I8N72_RS07900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I8N72_RS07910	COG0762	integral membrane protein
I8N72_RS07915	COG2302	S4 RNA-binding domain
I8N72_RS07920	COG3599	regulation of cell shape
I8N72_RS07925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8N72_RS07930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N72_RS07940	COG0564	pseudouridine synthase activity
I8N72_RS07950	COG2233	PERMEase
I8N72_RS07960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8N72_RS07965	COG0505	Belongs to the CarA family
I8N72_RS07970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N72_RS07985	COG0284	orotidine-5'-phosphate decarboxylase activity
I8N72_RS07990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8N72_RS08000	COG0306	phosphate transporter
I8N72_RS08015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N72_RS08020	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I8N72_RS08025	COG1648	precorrin-2 dehydrogenase activity
I8N72_RS08035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8N72_RS08040	COG1561	YicC-like family, N-terminal region
I8N72_RS08050	COG0194	GDP metabolic process
I8N72_RS08060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N72_RS08065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N72_RS08070	COG0242	peptide deformylase activity
I8N72_RS08080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8N72_RS08080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I8N72_RS08090	COG0631	protein serine/threonine phosphatase activity
I8N72_RS08095	COG2815	serine threonine protein kinase
I8N72_RS08095	COG0515	serine threonine protein kinase
I8N72_RS08105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8N72_RS08110	COG1564	THIamine pyrophosphokinase
I8N72_RS08125	COG1302	Protein conserved in bacteria
I8N72_RS08130	COG1461	Dihydroxyacetone kinase
I8N72_RS08135	COG1760	l-serine dehydratase
I8N72_RS08140	COG1760	l-serine dehydratase
I8N72_RS08145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I8N72_RS08160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N72_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS08180	COG1196	nuclear chromosome segregation
I8N72_RS08185	COG0552	protein localization to endoplasmic reticulum
I8N72_RS08200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I8N72_RS08210	COG1837	Belongs to the UPF0109 family
I8N72_RS08235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N72_RS08250	COG2257	FlhB HrpN YscU SpaS Family
I8N72_RS08260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I8N72_RS08265	COG0758	DNA mediated transformation
I8N72_RS08270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N72_RS08280	COG4974	Belongs to the 'phage' integrase family
I8N72_RS08300	COG1815	bacterial-type flagellum-dependent cell motility
I8N72_RS08305	COG1558	bacterial-type flagellum-dependent cell motility
I8N72_RS08310	COG1677	Flagellar hook-basal body complex protein FliE
I8N72_RS08315	COG1766	The M ring may be actively involved in energy transduction
I8N72_RS08320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N72_RS08325	COG1317	bacterial-type flagellum organization
I8N72_RS08330	COG1157	protein secretion by the type III secretion system
I8N72_RS08335	COG2882	bacterial-type flagellum organization
I8N72_RS08340	COG3334	PFAM MgtE intracellular
I8N72_RS08345	COG3144	bacterial-type flagellum assembly
I8N72_RS08350	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I8N72_RS08355	COG4786	Flagellar basal body rod
I8N72_RS08360	COG1582	Flagellar protein (FlbD)
I8N72_RS08365	COG1580	Controls the rotational direction of flagella during chemotaxis
I8N72_RS08370	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N72_RS08375	COG1776	CheC inhibitor of MCP methylation
I8N72_RS08375	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N72_RS08380	COG2201	protein-glutamate methylesterase activity
I8N72_RS08385	COG3190	flagellar
I8N72_RS08390	COG1338	Plays a role in the flagellum-specific transport system
I8N72_RS08395	COG1987	bacterial-type flagellum assembly
I8N72_RS08400	COG1684	flagellar biosynthetic protein fliR
I8N72_RS08405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N72_RS08410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N72_RS08415	COG1419	protein localization to endoplasmic reticulum
I8N72_RS08420	COG0455	bacterial-type flagellum organization
I8N72_RS08425	COG2201	protein-glutamate methylesterase activity
I8N72_RS08430	COG2198	Histidine kinase
I8N72_RS08430	COG0643	Histidine kinase
I8N72_RS08435	COG0835	chemotaxis
I8N72_RS08440	COG1776	CheC inhibitor of MCP methylation
I8N72_RS08450	COG1191	sigma factor activity
I8N72_RS08480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8N72_RS08485	COG4589	Belongs to the CDS family
I8N72_RS08495	COG0750	zinc metalloprotease
I8N72_RS08505	COG2176	DNA-directed DNA polymerase activity
I8N72_RS08515	COG0195	Participates in both transcription termination and antitermination
I8N72_RS08520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I8N72_RS08525	COG1358	cellular component organization or biogenesis
I8N72_RS08535	COG1550	Protein conserved in bacteria
I8N72_RS08550	COG0196	riboflavin kinase activity
I8N72_RS08565	COG0726	polysaccharide deacetylase
I8N72_RS08570	COG0612	Peptidase, M16
I8N72_RS08575	COG1873	PFAM PRC-barrel domain
I8N72_RS08580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N72_RS08585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N72_RS08590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I8N72_RS08595	COG0527	aspartate kinase activity
I8N72_RS08605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N72_RS08610	COG0740	serine-type endopeptidase activity
I8N72_RS08620	COG4980	gas vesicle protein
I8N72_RS08620	COG1674	ftsk spoiiie
I8N72_RS08625	COG2188	Transcriptional regulator
I8N72_RS08630	COG2814	Major facilitator Superfamily
I8N72_RS08635	COG1846	Transcriptional regulator
I8N72_RS08640	COG1033	growth of symbiont in host cell
I8N72_RS08640	COG2409	Drug exporters of the RND superfamily
I8N72_RS08645	COG0612	Peptidase, M16
I8N72_RS08650	COG0612	Peptidase, M16
I8N72_RS08655	COG0300	oxidoreductase activity
I8N72_RS08670	COG1426	Protein conserved in bacteria
I8N72_RS08675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8N72_RS08690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N72_RS08700	COG1692	metallophosphoesterase
I8N72_RS08705	COG2359	stage V sporulation protein S
I8N72_RS08725	COG4550	Control of competence regulator ComK, YlbF/YmcA
I8N72_RS08770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS08775	COG3425	synthase
I8N72_RS08780	COG1024	Enoyl-CoA hydratase
I8N72_RS08785	COG1024	Enoyl-CoA hydratase
I8N72_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS08790	COG3321	synthase
I8N72_RS08790	COG0300	oxidoreductase activity
I8N72_RS08790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS08790	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS08795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS08795	COG0300	oxidoreductase activity
I8N72_RS08795	COG3321	synthase
I8N72_RS08795	COG4221	oxidoreductase activity
I8N72_RS08800	COG3321	synthase
I8N72_RS08800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS08800	COG3321	synthase
I8N72_RS08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS08800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS08800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS08800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS08805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS08805	COG4221	oxidoreductase activity
I8N72_RS08805	COG3321	synthase
I8N72_RS08810	COG3321	synthase
I8N72_RS08810	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N72_RS08810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS08810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8N72_RS08815	COG2124	cytochrome p450
I8N72_RS08820	COG3209	COG3209 Rhs family protein
I8N72_RS08825	COG3619	membrane
I8N72_RS08835	COG1404	Belongs to the peptidase S8 family
I8N72_RS08845	COG4195	phage-related replication protein
I8N72_RS08850	COG1764	response to oxidative stress
I8N72_RS08860	COG2076	Multidrug Resistance protein
I8N72_RS08900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N72_RS08905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N72_RS08910	COG4112	unkown
I8N72_RS08915	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS08920	COG0464	growth
I8N72_RS08925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8N72_RS08930	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I8N72_RS08935	COG0789	Transcriptional regulator
I8N72_RS08940	COG0174	glutamine synthetase
I8N72_RS08950	COG2211	Major facilitator Superfamily
I8N72_RS08955	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N72_RS08970	COG1070	Carbohydrate kinase
I8N72_RS08975	COG3848	Pyruvate phosphate dikinase
I8N72_RS08975	COG0574	Belongs to the PEP-utilizing enzyme family
I8N72_RS08995	COG2378	regulation of single-species biofilm formation
I8N72_RS09000	COG2318	DinB family
I8N72_RS09005	COG1064	alcohol dehydrogenase
I8N72_RS09025	COG0456	acetyltransferase
I8N72_RS09045	COG3397	chitin binding
I8N72_RS09055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N72_RS09070	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N72_RS09075	COG0756	dUTP diphosphatase activity
I8N72_RS09080	COG4195	phage-related replication protein
I8N72_RS09115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N72_RS09125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I8N72_RS09145	COG0785	Cytochrome C biogenesis protein
I8N72_RS09150	COG2201	protein-glutamate methylesterase activity
I8N72_RS09155	COG4846	Membrane protein involved in cytochrome C biogenesis
I8N72_RS09165	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N72_RS09180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8N72_RS09185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS09205	COG0824	Thioesterase
I8N72_RS09215	COG4841	protein insertion into membrane
I8N72_RS09225	COG1832	CoA-binding protein
I8N72_RS09230	COG0187	DNA topoisomerase II activity
I8N72_RS09235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N72_RS09245	COG1115	amino acid carrier protein
I8N72_RS09255	COG1063	alcohol dehydrogenase
I8N72_RS09260	COG0800	Aldolase
I8N72_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS09275	COG1609	Transcriptional regulator
I8N72_RS09280	COG2271	Major facilitator Superfamily
I8N72_RS09315	COG2205	protein histidine kinase activity
I8N72_RS09320	COG0745	RESPONSE REGULATOR receiver
I8N72_RS09330	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N72_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS09360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N72_RS09365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N72_RS09370	COG2610	gluconate transmembrane transporter activity
I8N72_RS09375	COG2124	cytochrome p450
I8N72_RS09395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N72_RS09405	COG2246	polysaccharide biosynthetic process
I8N72_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N72_RS09415	COG0586	Pfam SNARE associated Golgi protein
I8N72_RS09420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N72_RS09425	COG1024	Enoyl-CoA hydratase
I8N72_RS09430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8N72_RS09435	COG0511	ligase activity, forming carbon-carbon bonds
I8N72_RS09440	COG0439	Biotin carboxylase
I8N72_RS09445	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS09450	COG1960	acyl-CoA dehydrogenase activity
I8N72_RS09455	COG1649	PFAM Uncharacterised BCR, COG1649
I8N72_RS09465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS09465	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N72_RS09470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS09480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS09490	COG2027	D-alanyl-D-alanine carboxypeptidase
I8N72_RS09495	COG2017	converts alpha-aldose to the beta-anomer
I8N72_RS09500	COG0534	Mate efflux family protein
I8N72_RS09515	COG0582	viral genome integration into host DNA
I8N72_RS09520	COG0166	Belongs to the GPI family
I8N72_RS09525	COG0405	Gamma-glutamyltransferase
I8N72_RS09530	COG2814	Major facilitator Superfamily
I8N72_RS09535	COG0640	Transcriptional regulator
I8N72_RS09550	COG0604	alcohol dehydrogenase
I8N72_RS09555	COG0493	'glutamate synthase
I8N72_RS09560	COG0067	glutamate synthase
I8N72_RS09560	COG0069	glutamate synthase activity
I8N72_RS09560	COG0070	glutamate synthase
I8N72_RS09565	COG0583	DNA-binding transcription factor activity
I8N72_RS09570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N72_RS09585	COG0300	oxidoreductase activity
I8N72_RS09590	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N72_RS09600	COG2814	Major facilitator Superfamily
I8N72_RS09605	COG1070	Carbohydrate kinase
I8N72_RS09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N72_RS09615	COG0243	molybdopterin cofactor binding
I8N72_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS09640	COG1733	regulation of RNA biosynthetic process
I8N72_RS09645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N72_RS09650	COG2207	Transcriptional regulator
I8N72_RS09650	COG0662	Cupin 2, conserved barrel domain protein
I8N72_RS09655	COG1309	transcriptional regulator
I8N72_RS09660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS09670	COG0640	Transcriptional regulator
I8N72_RS09675	COG0741	lytic transglycosylase activity
I8N72_RS09680	COG2322	membrane
I8N72_RS09695	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N72_RS09705	COG1388	LysM domain
I8N72_RS09705	COG3584	3D domain protein
I8N72_RS09710	COG0514	ATP-dependent DNA helicase (RecQ)
I8N72_RS09720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8N72_RS09725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N72_RS09740	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N72_RS09770	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS09775	COG1657	PFAM Prenyltransferase squalene oxidase
I8N72_RS09780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N72_RS09785	COG0733	neurotransmitter:sodium symporter activity
I8N72_RS09790	COG0385	Bile acid
I8N72_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS09800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N72_RS09810	COG4548	von Willebrand factor, type A
I8N72_RS09815	COG0714	Associated with various cellular activities
I8N72_RS09820	COG2032	superoxide dismutase activity
I8N72_RS09825	COG0791	NLP P60 protein
I8N72_RS09825	COG1388	LysM domain
I8N72_RS09830	COG1819	glycosyl
I8N72_RS09835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N72_RS09840	COG0534	Mate efflux family protein
I8N72_RS09845	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS09850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N72_RS09855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N72_RS09865	COG2962	Rard protein
I8N72_RS09880	COG1942	4-Oxalocrotonate Tautomerase
I8N72_RS09890	COG1733	regulation of RNA biosynthetic process
I8N72_RS09895	COG0778	Nitroreductase
I8N72_RS09900	COG0400	carboxylic ester hydrolase activity
I8N72_RS09905	COG0346	lactoylglutathione lyase activity
I8N72_RS09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N72_RS09925	COG2723	6-phospho-beta-galactosidase activity
I8N72_RS09930	COG2188	Transcriptional regulator
I8N72_RS09935	COG0793	Belongs to the peptidase S41A family
I8N72_RS09935	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS09940	COG2226	methyltransferase
I8N72_RS09950	COG1876	peptidase activity
I8N72_RS09970	COG0671	phosphoesterase, PA-phosphatase related
I8N72_RS10005	COG1509	lysine 2,3-aminomutase activity
I8N72_RS10010	COG0456	acetyltransferase
I8N72_RS10015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N72_RS10020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N72_RS10025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N72_RS10030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N72_RS10045	COG0456	acetyltransferase
I8N72_RS10050	COG0463	Glycosyl transferase, family 2
I8N72_RS10065	COG4641	Protein conserved in bacteria
I8N72_RS10075	COG1086	Polysaccharide biosynthesis protein
I8N72_RS10090	COG1846	Transcriptional regulator
I8N72_RS10095	COG4698	Protein conserved in bacteria
I8N72_RS10100	COG2755	lipolytic protein G-D-S-L family
I8N72_RS10105	COG1999	signal sequence binding
I8N72_RS10115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8N72_RS10120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I8N72_RS10125	COG1272	protein, Hemolysin III
I8N72_RS10130	COG0204	Acyl-transferase
I8N72_RS10135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N72_RS10150	COG2521	methyltransferase
I8N72_RS10150	COG2136	Putative SAM-dependent methyltransferase
I8N72_RS10165	COG1413	lyase activity
I8N72_RS10170	COG1418	mRNA catabolic process
I8N72_RS10175	COG0386	Belongs to the glutathione peroxidase family
I8N72_RS10185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N72_RS10195	COG1278	Cold shock
I8N72_RS10215	COG0328	RNA-DNA hybrid ribonuclease activity
I8N72_RS10220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I8N72_RS10225	COG0328	RNA-DNA hybrid ribonuclease activity
I8N72_RS10235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N72_RS10250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N72_RS10260	COG1755	Isoprenylcysteine carboxyl methyltransferase
I8N72_RS10265	COG3424	synthase
I8N72_RS10290	COG1335	isochorismatase
I8N72_RS10300	COG2233	PERMEase
I8N72_RS10310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I8N72_RS10315	COG1199	ATP-dependent helicase activity
I8N72_RS10335	COG0116	Belongs to the methyltransferase superfamily
I8N72_RS10365	COG3359	exonuclease
I8N72_RS10370	COG1111	helicase
I8N72_RS10370	COG1205	dead DEAH box helicase
I8N72_RS10375	COG2190	(PTS) system
I8N72_RS10380	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N72_RS10420	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N72_RS10420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N72_RS10430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I8N72_RS10435	COG3935	DnaD domain protein
I8N72_RS10445	COG0436	Aminotransferase
I8N72_RS10450	COG5353	protein conserved in bacteria
I8N72_RS10460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8N72_RS10460	COG1199	ATP-dependent helicase activity
I8N72_RS10490	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS10495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N72_RS10510	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N72_RS10515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS10520	COG2140	Oxalate decarboxylase
I8N72_RS10530	COG4347	Protein of unknown function (DUF1405)
I8N72_RS10535	COG2010	Cytochrome c
I8N72_RS10535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N72_RS10540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N72_RS10545	COG0723	plastoquinol--plastocyanin reductase activity
I8N72_RS10560	COG0457	Tetratricopeptide repeat
I8N72_RS10570	COG0287	Prephenate dehydrogenase
I8N72_RS10605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N72_RS10610	COG4401	Chorismate mutase type I
I8N72_RS10625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I8N72_RS10630	COG0105	UTP biosynthetic process
I8N72_RS10635	COG0142	geranyltranstransferase activity
I8N72_RS10645	COG0142	geranyltranstransferase activity
I8N72_RS10660	COG0776	regulation of translation
I8N72_RS10665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N72_RS10705	COG0539	negative regulation of cytoplasmic translation
I8N72_RS10720	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I8N72_RS10725	COG2959	enzyme of heme biosynthesis
I8N72_RS10730	COG3773	Cell wall hydrolase
I8N72_RS10730	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS10735	COG2339	peptidase activity
I8N72_RS10740	COG0492	ferredoxin-NADP+ reductase activity
I8N72_RS10745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N72_RS10750	COG4862	establishment of competence for transformation
I8N72_RS10755	COG1408	metallophosphoesterase
I8N72_RS10765	COG1388	LysM domain
I8N72_RS10770	COG1266	CAAX protease self-immunity
I8N72_RS10775	COG0514	ATP-dependent DNA helicase (RecQ)
I8N72_RS10780	COG4955	Helix-turn-helix domain
I8N72_RS10785	COG1141	Ferredoxin
I8N72_RS10790	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I8N72_RS10795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N72_RS10805	COG1595	DNA-templated transcription, initiation
I8N72_RS10810	COG5002	protein histidine kinase activity
I8N72_RS10815	COG0745	RESPONSE REGULATOR receiver
I8N72_RS10820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N72_RS10825	COG1333	cytochrome c biogenesis protein
I8N72_RS10830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS10835	COG1187	pseudouridine synthase activity
I8N72_RS10840	COG0700	Nucleoside recognition
I8N72_RS10845	COG2715	membrane protein required for spore maturation
I8N72_RS10850	COG1686	Belongs to the peptidase S11 family
I8N72_RS10875	COG1547	Domain of unknown function (DUF309)
I8N72_RS10880	COG0456	acetyltransferase
I8N72_RS10895	COG0307	riboflavin synthase, alpha
I8N72_RS10900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N72_RS10900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N72_RS10910	COG0681	Belongs to the peptidase S26 family
I8N72_RS10920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I8N72_RS10925	COG4086	secreted protein
I8N72_RS10930	COG0019	diaminopimelate decarboxylase activity
I8N72_RS10935	COG0697	spore germination
I8N72_RS10950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N72_RS10970	COG1191	sigma factor activity
I8N72_RS10980	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS10985	COG1686	Belongs to the peptidase S11 family
I8N72_RS10990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8N72_RS10995	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I8N72_RS11000	COG4974	Belongs to the 'phage' integrase family
I8N72_RS11010	COG0735	belongs to the Fur family
I8N72_RS11015	COG1300	Membrane
I8N72_RS11030	COG0281	malic enzyme
I8N72_RS11035	COG1757	Na H antiporter
I8N72_RS11040	COG1027	Aspartate ammonia-lyase
I8N72_RS11045	COG0252	asparaginase activity
I8N72_RS11050	COG1396	sequence-specific DNA binding
I8N72_RS11055	COG1379	DNA repair
I8N72_RS11060	COG0494	nUDIX hydrolase
I8N72_RS11070	COG0667	Aldo Keto reductase
I8N72_RS11080	COG1073	alpha beta
I8N72_RS11090	COG4918	Iron-sulphur cluster biosynthesis
I8N72_RS11095	COG0456	acetyltransferase
I8N72_RS11095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8N72_RS11100	COG2329	Antibiotic biosynthesis monooxygenase
I8N72_RS11105	COG0456	acetyltransferase
I8N72_RS11110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N72_RS11125	COG0628	permease
I8N72_RS11135	COG0346	lactoylglutathione lyase activity
I8N72_RS11145	COG3048	D-serine ammonia-lyase activity
I8N72_RS11150	COG0300	oxidoreductase activity
I8N72_RS11155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS11160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N72_RS11165	COG1024	Enoyl-CoA hydratase
I8N72_RS11170	COG3425	synthase
I8N72_RS11175	COG2124	cytochrome p450
I8N72_RS11180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS11180	COG3321	synthase
I8N72_RS11180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS11185	COG3321	synthase
I8N72_RS11185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11190	COG3321	synthase
I8N72_RS11190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11190	COG0300	oxidoreductase activity
I8N72_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS11195	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS11195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11195	COG3321	synthase
I8N72_RS11195	COG0300	oxidoreductase activity
I8N72_RS11200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS11200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS11200	COG3321	synthase
I8N72_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11205	COG3321	synthase
I8N72_RS11205	COG0300	oxidoreductase activity
I8N72_RS11205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11205	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS11210	COG3321	synthase
I8N72_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS11210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS11210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N72_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS11220	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS11235	COG2070	2-Nitropropane dioxygenase
I8N72_RS11235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N72_RS11240	COG0250	Participates in transcription elongation, termination and antitermination
I8N72_RS11260	COG0596	Alpha beta hydrolase
I8N72_RS11275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8N72_RS11280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8N72_RS11295	COG0706	membrane insertase activity
I8N72_RS11300	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8N72_RS11305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N72_RS11310	COG0346	lactoylglutathione lyase activity
I8N72_RS11320	COG1376	ErfK ybiS ycfS ynhG family protein
I8N72_RS11325	COG4129	membrane
I8N72_RS11330	COG1126	abc transporter atp-binding protein
I8N72_RS11335	COG0765	amino acid transport
I8N72_RS11340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS11350	COG1597	lipid kinase activity
I8N72_RS11355	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N72_RS11360	COG0022	dehydrogenase e1 component
I8N72_RS11365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N72_RS11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N72_RS11375	COG3426	butyrate kinase activity
I8N72_RS11380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N72_RS11385	COG0280	phosphate acetyltransferase
I8N72_RS11390	COG3829	transcription factor binding
I8N72_RS11390	COG3290	protein histidine kinase activity
I8N72_RS11400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I8N72_RS11405	COG2079	MmgE PrpD family protein
I8N72_RS11410	COG0372	Belongs to the citrate synthase family
I8N72_RS11415	COG1960	acyl-CoA dehydrogenase activity
I8N72_RS11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N72_RS11425	COG0183	Belongs to the thiolase family
I8N72_RS11430	COG0584	glycerophosphoryl diester phosphodiesterase
I8N72_RS11435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS11460	COG1902	pentaerythritol trinitrate reductase activity
I8N72_RS11475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N72_RS11480	COG0745	RESPONSE REGULATOR receiver
I8N72_RS11485	COG0750	zinc metalloprotease
I8N72_RS11490	COG0497	DNA recombination
I8N72_RS11500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I8N72_RS11510	COG0142	geranyltranstransferase activity
I8N72_RS11520	COG1570	exodeoxyribonuclease VII activity
I8N72_RS11535	COG1302	Protein conserved in bacteria
I8N72_RS11540	COG0439	Biotin carboxylase
I8N72_RS11545	COG0511	ligase activity, forming carbon-carbon bonds
I8N72_RS11585	COG3854	ATPases associated with a variety of cellular activities
I8N72_RS11600	COG0006	proline dipeptidase activity
I8N72_RS11610	COG3872	metal-dependent enzyme
I8N72_RS11620	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N72_RS11635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N72_RS11655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N72_RS11670	COG1396	sequence-specific DNA binding
I8N72_RS11680	COG0681	Belongs to the peptidase S26 family
I8N72_RS11705	COG4940	Competence protein ComGF
I8N72_RS11715	COG4970	Tfp pilus assembly protein FimT
I8N72_RS11720	COG4537	Required for transformation and DNA binding
I8N72_RS11725	COG1459	type II secretion system
I8N72_RS11730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8N72_RS11735	COG0598	Magnesium transport protein CorA
I8N72_RS11740	COG1253	flavin adenine dinucleotide binding
I8N72_RS11745	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS11755	COG1393	Belongs to the ArsC family
I8N72_RS11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS11775	COG0011	TIGRFAM Protein of
I8N72_RS11785	COG2866	Carboxypeptidase
I8N72_RS11790	COG1940	carbohydrate kinase activity
I8N72_RS11795	COG4483	Protein conserved in bacteria
I8N72_RS11800	COG1757	Na H antiporter
I8N72_RS11810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8N72_RS11825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N72_RS11830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N72_RS11835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N72_RS11840	COG0581	inorganic phosphate transmembrane transporter activity
I8N72_RS11845	COG0573	inorganic phosphate transmembrane transporter activity
I8N72_RS11850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8N72_RS11855	COG0768	penicillin binding
I8N72_RS11860	COG0477	Major facilitator Superfamily
I8N72_RS11865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N72_RS11870	COG2839	Protein conserved in bacteria
I8N72_RS11875	COG5521	maltodextrose utilization protein MalA
I8N72_RS11880	COG1388	LysM domain
I8N72_RS11890	COG4709	membrane
I8N72_RS11895	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I8N72_RS11900	COG0735	belongs to the Fur family
I8N72_RS11905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS11920	COG0513	Belongs to the DEAD box helicase family
I8N72_RS11935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8N72_RS11940	COG2384	SAM-dependent methyltransferase
I8N72_RS11945	COG2010	Cytochrome c
I8N72_RS11950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8N72_RS11955	COG0358	DNA primase activity
I8N72_RS11970	COG0517	IMP dehydrogenase activity
I8N72_RS11975	COG0751	glycine-tRNA ligase activity
I8N72_RS11995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8N72_RS12000	COG0295	cytidine deaminase activity
I8N72_RS12005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I8N72_RS12015	COG1480	7TM receptor with intracellular HD hydrolase
I8N72_RS12020	COG1702	phosphate starvation-inducible protein PhoH
I8N72_RS12025	COG0561	phosphatase activity
I8N72_RS12040	COG4864	UPF0365 protein
I8N72_RS12045	COG1030	water channel activity
I8N72_RS12050	COG1610	YqeY-like protein
I8N72_RS12060	COG1283	sodium-dependent phosphate transmembrane transporter activity
I8N72_RS12065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8N72_RS12070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8N72_RS12100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N72_RS12115	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS12130	COG1466	dna polymerase III delta subunit
I8N72_RS12145	COG2333	competence protein COMEC
I8N72_RS12145	COG0658	competence protein
I8N72_RS12150	COG2131	deaminase
I8N72_RS12155	COG1555	photosystem II stabilization
I8N72_RS12155	COG1596	polysaccharide export
I8N72_RS12160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N72_RS12165	COG2226	methyltransferase
I8N72_RS12170	COG0799	negative regulation of ribosome biogenesis
I8N72_RS12175	COG1713	HD superfamily hydrolase involved in NAD metabolism
I8N72_RS12185	COG1534	Rna-binding protein
I8N72_RS12190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8N72_RS12195	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N72_RS12200	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I8N72_RS12210	COG2755	lipolytic protein G-D-S-L family
I8N72_RS12220	COG0398	Pfam SNARE associated Golgi protein
I8N72_RS12245	COG3708	Transcriptional regulator
I8N72_RS12245	COG2207	Transcriptional regulator
I8N72_RS12250	COG0563	adenylate kinase activity
I8N72_RS12255	COG2814	Major facilitator Superfamily
I8N72_RS12265	COG0456	acetyltransferase
I8N72_RS12270	COG2318	DinB family
I8N72_RS12280	COG0561	phosphatase activity
I8N72_RS12285	COG0561	phosphatase activity
I8N72_RS12295	COG1482	cell wall glycoprotein biosynthetic process
I8N72_RS12300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N72_RS12300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N72_RS12300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS12305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS12305	COG3711	transcriptional antiterminator
I8N72_RS12315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8N72_RS12320	COG0583	DNA-binding transcription factor activity
I8N72_RS12325	COG2814	Major facilitator Superfamily
I8N72_RS12330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N72_RS12330	COG2124	cytochrome p450
I8N72_RS12335	COG1309	transcriptional regulator
I8N72_RS12340	COG2226	methyltransferase
I8N72_RS12355	COG2116	formate transmembrane transporter activity
I8N72_RS12360	COG5609	conserved protein (DUF2294)
I8N72_RS12365	COG3383	formate dehydrogenase (NAD+) activity
I8N72_RS12370	COG2427	Protein of unknown function (DUF1641)
I8N72_RS12380	COG0626	cystathionine gamma-synthase activity
I8N72_RS12385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N72_RS12410	COG0768	penicillin binding
I8N72_RS12430	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS12430	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS12435	COG4824	toxin secretion phage lysis holin
I8N72_RS12455	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N72_RS12460	COG1705	Flagellar rod assembly protein muramidase FlgJ
I8N72_RS12470	COG5280	Phage tail tape measure protein TP901
I8N72_RS12470	COG3953	SLT domain
I8N72_RS12565	COG0582	viral genome integration into host DNA
I8N72_RS12570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I8N72_RS12575	COG1595	DNA-templated transcription, initiation
I8N72_RS12680	COG1396	sequence-specific DNA binding
I8N72_RS12700	COG0826	peptidase U32
I8N72_RS12705	COG0826	peptidase U32
I8N72_RS12710	COG4122	O-methyltransferase activity
I8N72_RS12715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N72_RS12730	COG4472	Bacterial protein of unknown function (DUF965)
I8N72_RS12740	COG0628	permease
I8N72_RS12745	COG1126	abc transporter atp-binding protein
I8N72_RS12750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS12755	COG0765	amino acid transport
I8N72_RS12760	COG0765	amino acid transport
I8N72_RS12775	COG3881	PFAM PRC-barrel domain
I8N72_RS12780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8N72_RS12785	COG0457	Tetratricopeptide repeat
I8N72_RS12795	COG1104	cysteine desulfurase activity
I8N72_RS12800	COG1959	2 iron, 2 sulfur cluster binding
I8N72_RS12805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8N72_RS12810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I8N72_RS12835	COG4991	sh3 domain protein
I8N72_RS12835	COG3103	Sh3 type 3 domain protein
I8N72_RS12835	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS12845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8N72_RS12855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8N72_RS12855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I8N72_RS12860	COG5416	Lipopolysaccharide assembly protein A domain
I8N72_RS12865	COG0490	domain, Protein
I8N72_RS12870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N72_RS12870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N72_RS12880	COG2244	polysaccharide biosynthetic process
I8N72_RS12885	COG2323	membrane
I8N72_RS12895	COG1862	Preprotein translocase
I8N72_RS12940	COG1388	LysM domain
I8N72_RS12950	COG0157	Belongs to the NadC ModD family
I8N72_RS12955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8N72_RS12960	COG1104	cysteine desulfurase activity
I8N72_RS12965	COG1827	regulation of RNA biosynthetic process
I8N72_RS12970	COG0077	Prephenate dehydratase
I8N72_RS12985	COG3290	protein histidine kinase activity
I8N72_RS12990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8N72_RS12995	COG2868	ribosomal protein
I8N72_RS13005	COG1994	Peptidase M50
I8N72_RS13010	COG0739	heme binding
I8N72_RS13015	COG2894	cell division
I8N72_RS13025	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I8N72_RS13035	COG1077	Cell shape determining protein MreB Mrl
I8N72_RS13055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I8N72_RS13060	COG0285	dihydrofolate synthase activity
I8N72_RS13065	COG0525	valine-tRNA ligase activity
I8N72_RS13075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N72_RS13080	COG1388	LysM domain
I8N72_RS13090	COG0113	porphobilinogen synthase activity
I8N72_RS13095	COG1587	Uroporphyrinogen-III synthase
I8N72_RS13105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N72_RS13125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8N72_RS13130	COG0470	DNA polymerase III
I8N72_RS13130	COG1067	ATP-dependent peptidase activity
I8N72_RS13145	COG0457	Tetratricopeptide repeat
I8N72_RS13145	COG1477	protein flavinylation
I8N72_RS13160	COG0473	3-isopropylmalate dehydrogenase activity
I8N72_RS13175	COG0440	acetolactate synthase activity
I8N72_RS13180	COG0028	Belongs to the TPP enzyme family
I8N72_RS13205	COG0622	Phosphoesterase
I8N72_RS13210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8N72_RS13220	COG5401	PFAM Sporulation and spore germination
I8N72_RS13230	COG1846	Transcriptional regulator
I8N72_RS13235	COG2197	response regulator
I8N72_RS13240	COG0824	Thioesterase
I8N72_RS13245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8N72_RS13250	COG1053	succinate dehydrogenase
I8N72_RS13255	COG2009	succinate dehydrogenase
I8N72_RS13260	COG1719	4-vinyl reductase, 4VR
I8N72_RS13265	COG0527	aspartate kinase activity
I8N72_RS13275	COG3118	belongs to the thioredoxin family
I8N72_RS13280	COG3534	alpha-L-arabinofuranosidase
I8N72_RS13285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I8N72_RS13290	COG2086	electron transfer activity
I8N72_RS13295	COG1024	Enoyl-CoA hydratase
I8N72_RS13300	COG1309	transcriptional regulator
I8N72_RS13305	COG0318	PFAM AMP-dependent synthetase and ligase
I8N72_RS13315	COG3766	membrane
I8N72_RS13325	COG1796	DNA polymerase
I8N72_RS13325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N72_RS13330	COG1286	toxin biosynthetic process
I8N72_RS13345	COG0072	phenylalanine-tRNA ligase activity
I8N72_RS13345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N72_RS13350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8N72_RS13355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N72_RS13365	COG3835	regulator
I8N72_RS13370	COG0277	FAD linked oxidase domain protein
I8N72_RS13375	COG0247	lactate metabolic process
I8N72_RS13380	COG1966	Carbon starvation protein
I8N72_RS13385	COG3534	alpha-L-arabinofuranosidase
I8N72_RS13390	COG0395	ABC-type sugar transport system, permease component
I8N72_RS13395	COG1175	transmembrane transport
I8N72_RS13400	COG1653	transport
I8N72_RS13410	COG0647	UMP catabolic process
I8N72_RS13415	COG0235	Class ii aldolase
I8N72_RS13420	COG1069	ribulokinase activity
I8N72_RS13425	COG2160	L-arabinose isomerase activity
I8N72_RS13430	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N72_RS13435	COG1363	Peptidase, m42
I8N72_RS13445	COG3326	Membrane
I8N72_RS13450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8N72_RS13460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8N72_RS13465	COG1346	cytolysis
I8N72_RS13470	COG1380	Effector of murein hydrolase LrgA
I8N72_RS13475	COG3279	Response regulator of the LytR AlgR family
I8N72_RS13480	COG3275	phosphorelay sensor kinase activity
I8N72_RS13485	COG1011	Hydrolase
I8N72_RS13500	COG0398	Pfam SNARE associated Golgi protein
I8N72_RS13505	COG1484	DNA-dependent DNA replication
I8N72_RS13510	COG3611	Membrane attachment protein
I8N72_RS13525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N72_RS13530	COG1733	regulation of RNA biosynthetic process
I8N72_RS13535	COG2814	Major facilitator Superfamily
I8N72_RS13540	COG0656	L-ascorbic acid biosynthetic process
I8N72_RS13545	COG0237	dephospho-CoA kinase activity
I8N72_RS13550	COG1971	Probably functions as a manganese efflux pump
I8N72_RS13555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8N72_RS13560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N72_RS13560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N72_RS13565	COG5002	protein histidine kinase activity
I8N72_RS13570	COG0745	RESPONSE REGULATOR receiver
I8N72_RS13580	COG0538	isocitrate dehydrogenase activity
I8N72_RS13585	COG0372	Belongs to the citrate synthase family
I8N72_RS13605	COG0628	permease
I8N72_RS13610	COG3030	protein affecting phage T7 exclusion by the F plasmid
I8N72_RS13615	COG0469	pyruvate kinase activity
I8N72_RS13635	COG0281	malic enzyme
I8N72_RS13640	COG0587	DNA-directed DNA polymerase activity
I8N72_RS13660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I8N72_RS13670	COG4109	DRTGG domain
I8N72_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS13695	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8N72_RS13705	COG0827	DNA restriction-modification system
I8N72_RS13710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I8N72_RS13715	COG3874	Sporulation protein YtfJ
I8N72_RS13725	COG1714	RDD family
I8N72_RS13730	COG0616	signal peptide processing
I8N72_RS13735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N72_RS13740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8N72_RS13745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N72_RS13760	COG1104	cysteine desulfurase activity
I8N72_RS13765	COG1114	Component of the transport system for branched-chain amino acids
I8N72_RS13775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N72_RS13780	COG1309	transcriptional regulator
I8N72_RS13785	COG1956	GAF domain-containing protein
I8N72_RS13790	COG2199	diguanylate cyclase activity
I8N72_RS13790	COG2203	Gaf domain
I8N72_RS13800	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS13805	COG4282	regulation of fungal-type cell wall biogenesis
I8N72_RS13810	COG1017	nitric oxide dioxygenase activity
I8N72_RS13810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N72_RS13820	COG0693	protein deglycase activity
I8N72_RS13835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N72_RS13840	COG1378	Sugar-specific transcriptional regulator TrmB
I8N72_RS13860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N72_RS13865	COG0454	-acetyltransferase
I8N72_RS13870	COG0517	IMP dehydrogenase activity
I8N72_RS13875	COG0123	including yeast histone deacetylase and acetoin utilization protein
I8N72_RS13880	COG1360	Flagellar Motor Protein
I8N72_RS13885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N72_RS13890	COG1609	Transcriptional regulator
I8N72_RS13895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I8N72_RS13895	COG1605	Chorismate mutase
I8N72_RS13900	COG3118	belongs to the thioredoxin family
I8N72_RS13905	COG4980	gas vesicle protein
I8N72_RS13910	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N72_RS13920	COG1674	ftsk spoiiie
I8N72_RS13925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N72_RS13935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS13945	COG1363	Peptidase, m42
I8N72_RS13950	COG5584	Small secreted protein
I8N72_RS13955	COG0281	malic enzyme
I8N72_RS13960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N72_RS13975	COG0510	thiamine kinase activity
I8N72_RS13980	COG1597	lipid kinase activity
I8N72_RS13990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I8N72_RS13995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N72_RS14000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N72_RS14005	COG2252	PERMEase
I8N72_RS14010	COG4473	ABC transporter
I8N72_RS14015	COG1131	(ABC) transporter
I8N72_RS14020	COG1349	DNA-binding transcription factor activity
I8N72_RS14025	COG1187	pseudouridine synthase activity
I8N72_RS14030	COG2244	polysaccharide biosynthetic process
I8N72_RS14035	COG2081	HI0933 family
I8N72_RS14040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N72_RS14050	COG1609	Transcriptional regulator
I8N72_RS14055	COG1653	transport
I8N72_RS14060	COG1175	transmembrane transport
I8N72_RS14065	COG0395	ABC-type sugar transport system, permease component
I8N72_RS14070	COG1486	melibiose metabolic process
I8N72_RS14080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N72_RS14095	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N72_RS14095	COG2202	Pas domain
I8N72_RS14100	COG2814	Major facilitator Superfamily
I8N72_RS14105	COG5522	Integral membrane protein (intg_mem_TP0381)
I8N72_RS14110	COG0577	efflux transmembrane transporter activity
I8N72_RS14115	COG1136	(ABC) transporter
I8N72_RS14120	COG2205	protein histidine kinase activity
I8N72_RS14125	COG0745	RESPONSE REGULATOR receiver
I8N72_RS14130	COG0577	efflux transmembrane transporter activity
I8N72_RS14135	COG1136	(ABC) transporter
I8N72_RS14155	COG1131	(ABC) transporter
I8N72_RS14160	COG1725	Transcriptional regulator
I8N72_RS14170	COG1242	4 iron, 4 sulfur cluster binding
I8N72_RS14175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I8N72_RS14180	COG0584	glycerophosphoryl diester phosphodiesterase
I8N72_RS14190	COG2267	carboxylic ester hydrolase activity
I8N72_RS14195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I8N72_RS14200	COG1113	amino acid transport
I8N72_RS14205	COG0367	asparagine synthase
I8N72_RS14225	COG1506	peptidase
I8N72_RS14230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N72_RS14235	COG1116	anion transmembrane transporter activity
I8N72_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N72_RS14245	COG0494	nUDIX hydrolase
I8N72_RS14250	COG4824	toxin secretion phage lysis holin
I8N72_RS14255	COG0783	Belongs to the Dps family
I8N72_RS14280	COG0288	reversible hydration of carbon dioxide
I8N72_RS14290	COG1271	oxidase subunit
I8N72_RS14295	COG1294	oxidase, subunit
I8N72_RS14305	COG4948	Mandelate Racemase Muconate Lactonizing
I8N72_RS14315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8N72_RS14320	COG0596	Alpha beta hydrolase
I8N72_RS14330	COG1169	isochorismate synthase
I8N72_RS14335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N72_RS14340	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I8N72_RS14465	COG3859	Proton-coupled thiamine transporter YuaJ
I8N72_RS14470	COG2268	Band 7 protein
I8N72_RS14475	COG1585	Membrane protein implicated in regulation of membrane protease activity
I8N72_RS14480	COG2318	DinB family
I8N72_RS14490	COG1454	alcohol dehydrogenase
I8N72_RS14495	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS14500	COG1510	regulation of RNA biosynthetic process
I8N72_RS14510	COG0569	domain protein
I8N72_RS14515	COG1705	Flagellar rod assembly protein muramidase FlgJ
I8N72_RS14520	COG1017	nitric oxide dioxygenase activity
I8N72_RS14520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N72_RS14535	COG0457	Tetratricopeptide repeat
I8N72_RS14560	COG0628	permease
I8N72_RS14565	COG0673	inositol 2-dehydrogenase activity
I8N72_RS14570	COG0693	protein deglycase activity
I8N72_RS14575	COG0840	transmembrane signaling receptor activity
I8N72_RS14580	COG0840	transmembrane signaling receptor activity
I8N72_RS14585	COG0840	transmembrane signaling receptor activity
I8N72_RS14590	COG0840	transmembrane signaling receptor activity
I8N72_RS14605	COG2070	2-Nitropropane dioxygenase
I8N72_RS14610	COG0432	Pfam Uncharacterised protein family UPF0047
I8N72_RS14615	COG0366	Alpha amylase catalytic
I8N72_RS14620	COG1253	flavin adenine dinucleotide binding
I8N72_RS14625	COG2738	Putative neutral zinc metallopeptidase
I8N72_RS14640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8N72_RS14670	COG1335	isochorismatase
I8N72_RS14675	COG1979	alcohol dehydrogenase
I8N72_RS14680	COG1979	alcohol dehydrogenase
I8N72_RS14685	COG2155	Conserved Protein
I8N72_RS14690	COG1098	S1 RNA binding domain
I8N72_RS14695	COG0436	Aminotransferase
I8N72_RS14700	COG1522	sequence-specific DNA binding
I8N72_RS14705	COG2267	carboxylic ester hydrolase activity
I8N72_RS14715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8N72_RS14720	COG2205	protein histidine kinase activity
I8N72_RS14730	COG5018	Exonuclease
I8N72_RS14735	COG2814	Major facilitator Superfamily
I8N72_RS14740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N72_RS14745	COG3011	Protein conserved in bacteria
I8N72_RS14755	COG3290	protein histidine kinase activity
I8N72_RS14760	COG4565	transcriptional regulatory protein
I8N72_RS14765	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N72_RS14770	COG3845	ABC transporter
I8N72_RS14775	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8N72_RS14780	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8N72_RS14790	COG2111	Na H antiporter
I8N72_RS14790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8N72_RS14795	COG2111	Na H antiporter
I8N72_RS14800	COG1006	Multisubunit Na H antiporter MnhC subunit
I8N72_RS14805	COG0651	ATP synthesis coupled electron transport
I8N72_RS14810	COG1863	multisubunit Na H antiporter MnhE subunit
I8N72_RS14815	COG2212	antiporter activity
I8N72_RS14820	COG1320	monovalent cation:proton antiporter activity
I8N72_RS14825	COG2050	protein possibly involved in aromatic compounds catabolism
I8N72_RS14830	COG2197	response regulator
I8N72_RS14835	COG4585	Histidine kinase
I8N72_RS14845	COG0142	geranyltranstransferase activity
I8N72_RS14860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I8N72_RS14865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I8N72_RS14870	COG1335	isochorismatase
I8N72_RS14875	COG5506	Protein of unknown function (DUF1694)
I8N72_RS14890	COG0628	permease
I8N72_RS14900	COG1418	mRNA catabolic process
I8N72_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS14915	COG1511	domain protein
I8N72_RS14920	COG0433	COG0433 Predicted ATPase
I8N72_RS14920	COG1674	ftsk spoiiie
I8N72_RS14925	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N72_RS14930	COG5417	Belongs to the EsaB family
I8N72_RS14935	COG4842	Belongs to the WXG100 family
I8N72_RS14940	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I8N72_RS14940	COG2508	Transcriptional regulator
I8N72_RS14945	COG0686	Belongs to the AlaDH PNT family
I8N72_RS14950	COG5634	Uncharacterized conserved protein (DUF2278)
I8N72_RS14955	COG3251	PFAM MbtH domain protein
I8N72_RS14960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N72_RS14965	COG1535	isochorismatase
I8N72_RS14965	COG3433	isochorismatase activity
I8N72_RS14970	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8N72_RS14975	COG1169	isochorismate synthase
I8N72_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS14985	COG2819	hydrolase of the alpha beta superfamily
I8N72_RS14990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N72_RS14995	COG1268	BioY protein
I8N72_RS15000	COG2056	Na+-H+ antiporter family
I8N72_RS15010	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I8N72_RS15015	COG3584	3D domain protein
I8N72_RS15030	COG1252	NADH dehydrogenase
I8N72_RS15060	COG1131	(ABC) transporter
I8N72_RS15085	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I8N72_RS15090	COG0316	Belongs to the HesB IscA family
I8N72_RS15100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N72_RS15110	COG1252	NADH dehydrogenase
I8N72_RS15115	COG4837	Protein of unknown function (DUF1462)
I8N72_RS15120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I8N72_RS15125	COG0823	Involved in the tonB-independent uptake of proteins
I8N72_RS15125	COG1506	peptidase
I8N72_RS15125	COG4946	Tricorn protease homolog
I8N72_RS15135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8N72_RS15140	COG0460	homoserine dehydrogenase
I8N72_RS15145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N72_RS15150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8N72_RS15155	COG0647	UMP catabolic process
I8N72_RS15160	COG2445	Protein of unknown function DUF86
I8N72_RS15165	COG4470	Protein conserved in bacteria
I8N72_RS15175	COG0739	heme binding
I8N72_RS15185	COG0737	Belongs to the 5'-nucleotidase family
I8N72_RS15190	COG0730	response to heat
I8N72_RS15195	COG1801	Protein of unknown function DUF72
I8N72_RS15210	COG2508	Transcriptional regulator
I8N72_RS15220	COG2814	Major facilitator Superfamily
I8N72_RS15225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8N72_RS15230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N72_RS15235	COG2356	endonuclease I
I8N72_RS15240	COG3842	ATPase activity
I8N72_RS15245	COG2188	Transcriptional regulator
I8N72_RS15250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N72_RS15255	COG0395	ABC-type sugar transport system, permease component
I8N72_RS15260	COG1175	transmembrane transport
I8N72_RS15265	COG1653	transport
I8N72_RS15270	COG2222	sugar isomerase
I8N72_RS15275	COG0789	Transcriptional regulator
I8N72_RS15290	COG0322	excinuclease ABC activity
I8N72_RS15295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N72_RS15305	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS15310	COG0719	Fe-S assembly protein
I8N72_RS15315	COG0822	iron-sulfur transferase activity
I8N72_RS15320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N72_RS15325	COG0719	Fe-S assembly protein
I8N72_RS15330	COG0396	ATPase activity
I8N72_RS15340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N72_RS15345	COG1464	Belongs to the NlpA lipoprotein family
I8N72_RS15350	COG2011	ABC-type metal ion transport system permease component
I8N72_RS15355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8N72_RS15365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N72_RS15370	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N72_RS15385	COG1393	Belongs to the ArsC family
I8N72_RS15390	COG1960	acyl-CoA dehydrogenase activity
I8N72_RS15395	COG0183	Belongs to the thiolase family
I8N72_RS15400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N72_RS15400	COG1024	Enoyl-CoA hydratase
I8N72_RS15420	COG5577	PFAM Coat F domain
I8N72_RS15425	COG1846	Transcriptional regulator
I8N72_RS15430	COG0477	Major facilitator Superfamily
I8N72_RS15435	COG0583	DNA-binding transcription factor activity
I8N72_RS15455	COG1120	ATPase activity
I8N72_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS15475	COG0783	Belongs to the Dps family
I8N72_RS15480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N72_RS15485	COG0745	RESPONSE REGULATOR receiver
I8N72_RS15490	COG2770	Histidine kinase
I8N72_RS15490	COG2205	protein histidine kinase activity
I8N72_RS15500	COG1309	transcriptional regulator
I8N72_RS15505	COG0114	fumarate hydratase activity
I8N72_RS15515	COG0697	spore germination
I8N72_RS15520	COG0814	amino acid
I8N72_RS15530	COG2197	response regulator
I8N72_RS15535	COG4585	Histidine kinase
I8N72_RS15540	COG4758	membrane
I8N72_RS15545	COG3595	metallopeptidase activity
I8N72_RS15550	COG1842	Phage shock protein A
I8N72_RS15555	COG4758	membrane
I8N72_RS15560	COG2814	Major facilitator Superfamily
I8N72_RS15565	COG2096	Adenosyltransferase
I8N72_RS15570	COG1120	ATPase activity
I8N72_RS15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS15580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N72_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS15590	COG3386	PFAM SMP-30 Gluconolaconase
I8N72_RS15595	COG2205	protein histidine kinase activity
I8N72_RS15600	COG0745	RESPONSE REGULATOR receiver
I8N72_RS15610	COG1191	sigma factor activity
I8N72_RS15620	COG2140	Oxalate decarboxylase
I8N72_RS15630	COG1120	ATPase activity
I8N72_RS15635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS15645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N72_RS15650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8N72_RS15655	COG0531	amino acid
I8N72_RS15665	COG1988	membrane-bound metal-dependent
I8N72_RS15670	COG1368	sulfuric ester hydrolase activity
I8N72_RS15675	COG1910	domain protein
I8N72_RS15680	COG0725	ABC transporter, periplasmic molybdate-binding protein
I8N72_RS15685	COG4149	molybdate abc transporter
I8N72_RS15690	COG2197	response regulator
I8N72_RS15695	COG3850	Histidine kinase
I8N72_RS15700	COG1131	(ABC) transporter
I8N72_RS15710	COG0842	Transport permease protein
I8N72_RS15715	COG0656	L-ascorbic acid biosynthetic process
I8N72_RS15735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N72_RS15740	COG3973	AAA domain
I8N72_RS15745	COG2860	membrane
I8N72_RS15755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I8N72_RS15760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8N72_RS15765	COG2217	Heavy metal translocating P-type atpase
I8N72_RS15770	COG2217	Heavy metal translocating P-type atpase
I8N72_RS15775	COG2608	mercury ion transmembrane transporter activity
I8N72_RS15780	COG1937	Protein conserved in bacteria
I8N72_RS15785	COG0673	inositol 2-dehydrogenase activity
I8N72_RS15800	COG2814	Major facilitator Superfamily
I8N72_RS15815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS15820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I8N72_RS15825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS15830	COG1126	abc transporter atp-binding protein
I8N72_RS15835	COG0765	amino acid transport
I8N72_RS15840	COG0765	amino acid transport
I8N72_RS15845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N72_RS15855	COG0454	-acetyltransferase
I8N72_RS15860	COG0583	DNA-binding transcription factor activity
I8N72_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS15870	COG2732	(Barnase) inhibitor
I8N72_RS15890	COG0557	exoribonuclease II activity
I8N72_RS15895	COG1647	Serine aminopeptidase, S33
I8N72_RS15900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N72_RS15905	COG1476	TRANSCRIPTIONal
I8N72_RS15910	COG1396	sequence-specific DNA binding
I8N72_RS15915	COG1396	sequence-specific DNA binding
I8N72_RS15920	COG1733	regulation of RNA biosynthetic process
I8N72_RS15945	COG1131	(ABC) transporter
I8N72_RS15950	COG1174	glycine betaine transport
I8N72_RS15955	COG1732	Glycine betaine
I8N72_RS15960	COG1174	glycine betaine transport
I8N72_RS15965	COG1125	glycine betaine transport
I8N72_RS15965	COG0517	IMP dehydrogenase activity
I8N72_RS15970	COG1510	regulation of RNA biosynthetic process
I8N72_RS15975	COG1174	glycine betaine transport
I8N72_RS15980	COG1732	Glycine betaine
I8N72_RS15985	COG1174	glycine betaine transport
I8N72_RS15990	COG0517	IMP dehydrogenase activity
I8N72_RS15990	COG1125	glycine betaine transport
I8N72_RS15995	COG1510	regulation of RNA biosynthetic process
I8N72_RS16000	COG2095	MarC family integral membrane protein
I8N72_RS16005	COG3064	Membrane
I8N72_RS16010	COG4640	response to antibiotic
I8N72_RS16015	COG0456	acetyltransferase
I8N72_RS16030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N72_RS16045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N72_RS16050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N72_RS16055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N72_RS16065	COG2234	aminopeptidase activity
I8N72_RS16085	COG0126	phosphoglycerate kinase activity
I8N72_RS16095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N72_RS16100	COG2390	Transcriptional regulator
I8N72_RS16105	COG2814	Major facilitator Superfamily
I8N72_RS16110	COG1609	Transcriptional regulator
I8N72_RS16115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS16125	COG0583	DNA-binding transcription factor activity
I8N72_RS16130	COG0697	spore germination
I8N72_RS16135	COG1113	amino acid transport
I8N72_RS16145	COG1609	Transcriptional regulator
I8N72_RS16155	COG0561	phosphatase activity
I8N72_RS16160	COG1737	Transcriptional regulator
I8N72_RS16165	COG1070	Carbohydrate kinase
I8N72_RS16190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N72_RS16195	COG2186	Transcriptional regulator
I8N72_RS16200	COG1620	l-lactate permease
I8N72_RS16205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I8N72_RS16215	COG5039	Polysaccharide pyruvyl transferase
I8N72_RS16220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N72_RS16225	COG0110	maltose O-acetyltransferase activity
I8N72_RS16230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8N72_RS16235	COG2244	polysaccharide biosynthetic process
I8N72_RS16240	COG1216	Glycosyl transferase, family 2
I8N72_RS16245	COG5039	Polysaccharide pyruvyl transferase
I8N72_RS16250	COG1216	Glycosyl transferase, family 2
I8N72_RS16260	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS16265	COG1215	transferase activity, transferring glycosyl groups
I8N72_RS16270	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS16275	COG1086	Polysaccharide biosynthesis protein
I8N72_RS16280	COG0489	protein tyrosine kinase activity
I8N72_RS16285	COG3944	biosynthesis protein
I8N72_RS16290	COG1396	sequence-specific DNA binding
I8N72_RS16295	COG2272	Belongs to the type-B carboxylesterase lipase family
I8N72_RS16305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N72_RS16310	COG2364	Membrane
I8N72_RS16315	COG0456	acetyltransferase
I8N72_RS16320	COG3479	Phenolic acid decarboxylase
I8N72_RS16385	COG2223	nitrite transmembrane transporter activity
I8N72_RS16390	COG1609	Transcriptional regulator
I8N72_RS16400	COG0583	DNA-binding transcription factor activity
I8N72_RS16405	COG2828	Protein conserved in bacteria
I8N72_RS16410	COG0477	Major facilitator Superfamily
I8N72_RS16410	COG2814	Major facilitator Superfamily
I8N72_RS16415	COG1611	Belongs to the LOG family
I8N72_RS16420	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N72_RS16425	COG0659	secondary active sulfate transmembrane transporter activity
I8N72_RS16430	COG0288	reversible hydration of carbon dioxide
I8N72_RS16435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N72_RS16440	COG4290	ribonuclease
I8N72_RS16445	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I8N72_RS16450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS16460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8N72_RS16470	COG1051	belongs to the nudix hydrolase family
I8N72_RS16475	COG0492	ferredoxin-NADP+ reductase activity
I8N72_RS16480	COG0791	NLP P60 protein
I8N72_RS16480	COG3883	PFAM NLP P60 protein
I8N72_RS16485	COG0457	Tetratricopeptide repeat
I8N72_RS16490	COG5002	protein histidine kinase activity
I8N72_RS16495	COG0745	RESPONSE REGULATOR receiver
I8N72_RS16505	COG1132	(ABC) transporter
I8N72_RS16510	COG0140	phosphoribosyl-ATP diphosphatase activity
I8N72_RS16510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8N72_RS16535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8N72_RS16550	COG4990	cell redox homeostasis
I8N72_RS16555	COG0110	maltose O-acetyltransferase activity
I8N72_RS16575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8N72_RS16585	COG2188	Transcriptional regulator
I8N72_RS16590	COG1309	transcriptional regulator
I8N72_RS16595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N72_RS16600	COG1950	PFAM Membrane protein of
I8N72_RS16605	COG1983	PspC domain protein
I8N72_RS16610	COG3595	metallopeptidase activity
I8N72_RS16625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8N72_RS16635	COG4897	Protein conserved in bacteria
I8N72_RS16640	COG0574	Belongs to the PEP-utilizing enzyme family
I8N72_RS16640	COG3848	Pyruvate phosphate dikinase
I8N72_RS16645	COG1309	transcriptional regulator
I8N72_RS16650	COG2814	Major facilitator Superfamily
I8N72_RS16685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N72_RS16695	COG0793	Belongs to the peptidase S41A family
I8N72_RS16695	COG3409	Peptidoglycan-binding domain 1 protein
I8N72_RS16700	COG3420	alginic acid biosynthetic process
I8N72_RS16705	COG2177	Part of the ABC transporter FtsEX involved in
I8N72_RS16710	COG2884	Cell division ATP-binding protein ftsE
I8N72_RS16715	COG2010	Cytochrome c
I8N72_RS16720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS16735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8N72_RS16750	COG1516	flagellar protein fliS
I8N72_RS16755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I8N72_RS16760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N72_RS16780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N72_RS16785	COG4786	Flagellar basal body rod
I8N72_RS16785	COG1256	bacterial-type flagellum assembly
I8N72_RS16790	COG3418	PFAM FlgN family protein
I8N72_RS16795	COG2747	anti-sigma28 factor FlgM
I8N72_RS16805	COG1040	competence protein
I8N72_RS16815	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I8N72_RS16820	COG1307	EDD domain protein, DegV family
I8N72_RS16825	COG2197	response regulator
I8N72_RS16830	COG4585	Histidine kinase
I8N72_RS16835	COG1739	Uncharacterized protein family UPF0029
I8N72_RS16840	COG1316	TRANSCRIPTIONal
I8N72_RS16845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8N72_RS16850	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS16855	COG1215	transferase activity, transferring glycosyl groups
I8N72_RS16860	COG3206	protein involved in exopolysaccharide biosynthesis
I8N72_RS16865	COG3307	-O-antigen
I8N72_RS16870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N72_RS16875	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS16875	COG0297	glycogen (starch) synthase activity
I8N72_RS16880	COG2244	polysaccharide biosynthetic process
I8N72_RS16890	COG2247	cell wall binding repeat
I8N72_RS16890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N72_RS16895	COG2247	cell wall binding repeat
I8N72_RS16895	COG2385	sporulation resulting in formation of a cellular spore
I8N72_RS16905	COG1316	TRANSCRIPTIONal
I8N72_RS16910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I8N72_RS16915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N72_RS16920	COG1134	teichoic acid transport
I8N72_RS16925	COG1682	transport, permease protein
I8N72_RS16930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N72_RS16940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8N72_RS16945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I8N72_RS16950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N72_RS16955	COG4193	domain, Protein
I8N72_RS16960	COG1482	cell wall glycoprotein biosynthetic process
I8N72_RS16965	COG0697	spore germination
I8N72_RS16970	COG0814	amino acid
I8N72_RS16980	COG1215	transferase activity, transferring glycosyl groups
I8N72_RS16985	COG2814	Major facilitator Superfamily
I8N72_RS16990	COG1316	TRANSCRIPTIONal
I8N72_RS16995	COG0561	phosphatase activity
I8N72_RS17000	COG2433	Pfam Transposase IS66
I8N72_RS17005	COG0791	NLP P60 protein
I8N72_RS17015	COG2843	Capsule synthesis protein
I8N72_RS17025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8N72_RS17030	COG0697	spore germination
I8N72_RS17035	COG0814	amino acid
I8N72_RS17045	COG1609	Transcriptional regulator
I8N72_RS17050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N72_RS17060	COG1129	ABC transporter
I8N72_RS17065	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8N72_RS17070	COG1879	ABC-type sugar transport system periplasmic component
I8N72_RS17075	COG3103	Sh3 type 3 domain protein
I8N72_RS17080	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N72_RS17085	COG3527	Alpha-acetolactate decarboxylase
I8N72_RS17090	COG0028	Belongs to the TPP enzyme family
I8N72_RS17095	COG0583	DNA-binding transcription factor activity
I8N72_RS17100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N72_RS17115	COG5337	Spore coat protein CotH
I8N72_RS17125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8N72_RS17135	COG0405	Gamma-glutamyltransferase
I8N72_RS17140	COG1522	sequence-specific DNA binding
I8N72_RS17145	COG2059	Chromate
I8N72_RS17150	COG2059	Chromate
I8N72_RS17160	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N72_RS17165	COG0583	DNA-binding transcription factor activity
I8N72_RS17190	COG5444	nuclease activity
I8N72_RS17215	COG5444	nuclease activity
I8N72_RS17230	COG3878	Protein conserved in bacteria
I8N72_RS17235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N72_RS17240	COG4464	protein tyrosine phosphatase activity
I8N72_RS17245	COG0489	protein tyrosine kinase activity
I8N72_RS17250	COG3944	biosynthesis protein
I8N72_RS17260	COG4715	Zinc finger, swim domain protein
I8N72_RS17265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N72_RS17270	COG0561	phosphatase activity
I8N72_RS17275	COG1349	DNA-binding transcription factor activity
I8N72_RS17280	COG0629	single-stranded DNA binding
I8N72_RS17305	COG0457	Tetratricopeptide repeat
I8N72_RS17310	COG4786	Flagellar basal body rod
I8N72_RS17315	COG4786	Flagellar basal body rod
I8N72_RS17320	COG1077	Cell shape determining protein MreB Mrl
I8N72_RS17330	COG1846	Transcriptional regulator
I8N72_RS17335	COG2814	Major facilitator Superfamily
I8N72_RS17340	COG1953	Uracil, thiamine, allantoin
I8N72_RS17345	COG0477	Major facilitator Superfamily
I8N72_RS17350	COG1335	isochorismatase
I8N72_RS17355	COG0004	ammonium transporteR
I8N72_RS17360	COG0347	Belongs to the P(II) protein family
I8N72_RS17365	COG0772	Belongs to the SEDS family
I8N72_RS17370	COG0671	phosphoesterase, PA-phosphatase related
I8N72_RS17380	COG0739	heme binding
I8N72_RS17385	COG1247	-acetyltransferase
I8N72_RS17400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N72_RS17410	COG0726	polysaccharide deacetylase
I8N72_RS17420	COG1959	2 iron, 2 sulfur cluster binding
I8N72_RS17435	COG0831	urea catabolic process
I8N72_RS17440	COG3237	CsbD-like
I8N72_RS17445	COG1994	Peptidase M50
I8N72_RS17450	COG0457	Tetratricopeptide repeat
I8N72_RS17460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8N72_RS17470	COG2304	oxidoreductase activity
I8N72_RS17475	COG2304	oxidoreductase activity
I8N72_RS17480	COG2385	sporulation resulting in formation of a cellular spore
I8N72_RS17485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N72_RS17495	COG4836	Membrane
I8N72_RS17565	COG0698	ribose 5-phosphate isomerase
I8N72_RS17570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N72_RS17580	COG0009	L-threonylcarbamoyladenylate synthase
I8N72_RS17585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8N72_RS17605	COG2890	protein-(glutamine-N5) methyltransferase activity
I8N72_RS17610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8N72_RS17615	COG0346	lactoylglutathione lyase activity
I8N72_RS17620	COG0789	Transcriptional regulator
I8N72_RS17625	COG0679	Auxin Efflux Carrier
I8N72_RS17630	COG0281	malic enzyme
I8N72_RS17645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I8N72_RS17650	COG1494	fructose-1,6-bisphosphatase
I8N72_RS17655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N72_RS17665	COG0191	fructose-bisphosphate aldolase activity
I8N72_RS17670	COG2204	response regulator
I8N72_RS17675	COG4821	SIS domain
I8N72_RS17690	COG2181	nitrate reductase activity
I8N72_RS17690	COG0247	lactate metabolic process
I8N72_RS17695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N72_RS17710	COG1132	(ABC) transporter
I8N72_RS17715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N72_RS17725	COG2181	nitrate reductase activity
I8N72_RS17730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I8N72_RS17735	COG1140	nitrate reductase beta subunit
I8N72_RS17745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N72_RS17755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N72_RS17760	COG2223	nitrite transmembrane transporter activity
I8N72_RS17770	COG4506	Protein conserved in bacteria
I8N72_RS17775	COG0457	Tetratricopeptide repeat
I8N72_RS17810	COG0010	Belongs to the arginase family
I8N72_RS17815	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I8N72_RS17820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N72_RS17835	COG1994	Peptidase M50
I8N72_RS17840	COG1942	4-Oxalocrotonate Tautomerase
I8N72_RS17845	COG1846	Transcriptional regulator
I8N72_RS17850	COG0531	amino acid
I8N72_RS17855	COG3465	dGTPase activity
I8N72_RS17860	COG1078	dGTPase activity
I8N72_RS17875	COG1695	Transcriptional regulator
I8N72_RS17895	COG0583	DNA-binding transcription factor activity
I8N72_RS17900	COG2855	membrane
I8N72_RS17905	COG0280	phosphate acetyltransferase
I8N72_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS17920	COG0436	Aminotransferase
I8N72_RS17950	COG2814	Major facilitator Superfamily
I8N72_RS17955	COG2814	Major facilitator Superfamily
I8N72_RS17960	COG0833	amino acid
I8N72_RS17965	COG4187	Peptidase family M20/M25/M40
I8N72_RS17970	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS17975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N72_RS17985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I8N72_RS17990	COG1091	dTDP-4-dehydrorhamnose reductase activity
I8N72_RS17995	COG1088	dTDP-glucose 4,6-dehydratase activity
I8N72_RS18000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I8N72_RS18005	COG3980	spore coat polysaccharide biosynthesis protein
I8N72_RS18010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I8N72_RS18015	COG2089	acid synthase
I8N72_RS18020	COG0456	acetyltransferase
I8N72_RS18025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N72_RS18030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N72_RS18035	COG0463	Glycosyl transferase, family 2
I8N72_RS18045	COG2363	Small membrane protein
I8N72_RS18050	COG2233	PERMEase
I8N72_RS18065	COG1216	Glycosyl transferase, family 2
I8N72_RS18080	COG1695	Transcriptional regulator
I8N72_RS18085	COG0351	phosphomethylpyrimidine kinase
I8N72_RS18095	COG1621	beta-fructofuranosidase activity
I8N72_RS18100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N72_RS18100	COG1263	PTS System
I8N72_RS18105	COG3711	transcriptional antiterminator
I8N72_RS18115	COG1404	Belongs to the peptidase S8 family
I8N72_RS18120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N72_RS18125	COG0778	Nitroreductase
I8N72_RS18130	COG0772	Belongs to the SEDS family
I8N72_RS18135	COG0454	-acetyltransferase
I8N72_RS18155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N72_RS18160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N72_RS18165	COG2261	transglycosylase associated protein
I8N72_RS18170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N72_RS18180	COG2246	polysaccharide biosynthetic process
I8N72_RS18185	COG1309	transcriptional regulator
I8N72_RS18205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N72_RS18210	COG2837	iron assimilation
I8N72_RS18230	COG0583	DNA-binding transcription factor activity
I8N72_RS18240	COG1346	cytolysis
I8N72_RS18245	COG4895	conserved protein (DUF2196)
I8N72_RS18250	COG0789	Transcriptional regulator
I8N72_RS18255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I8N72_RS18260	COG0346	lactoylglutathione lyase activity
I8N72_RS18265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS18270	COG1404	Belongs to the peptidase S8 family
I8N72_RS18275	COG1442	glycosyl transferase family 8
I8N72_RS18280	COG2357	RelA SpoT domain protein
I8N72_RS18285	COG1575	Belongs to the MenA family. Type 1 subfamily
I8N72_RS18300	COG1696	Membrane protein involved in D-alanine export
I8N72_RS18310	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I8N72_RS18315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N72_RS18320	COG1486	melibiose metabolic process
I8N72_RS18325	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N72_RS18330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS18335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS18340	COG3711	transcriptional antiterminator
I8N72_RS18340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N72_RS18350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N72_RS18365	COG0640	Transcriptional regulator
I8N72_RS18370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N72_RS18375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS18380	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N72_RS18385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N72_RS18390	COG2723	6-phospho-beta-galactosidase activity
I8N72_RS18395	COG1940	carbohydrate kinase activity
I8N72_RS18400	COG1482	cell wall glycoprotein biosynthetic process
I8N72_RS18410	COG0753	catalase activity
I8N72_RS18415	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I8N72_RS18420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N72_RS18425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8N72_RS18430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I8N72_RS18435	COG4988	ABC transporter
I8N72_RS18440	COG1294	oxidase, subunit
I8N72_RS18445	COG1271	oxidase subunit
I8N72_RS18450	COG3493	citrate carrier protein
I8N72_RS18455	COG0726	polysaccharide deacetylase
I8N72_RS18460	COG3842	ATPase activity
I8N72_RS18465	COG2508	Transcriptional regulator
I8N72_RS18470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS18480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N72_RS18495	COG4894	glucomannan catabolic process
I8N72_RS18500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N72_RS18505	COG0500	methyltransferase
I8N72_RS18510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N72_RS18525	COG0753	catalase activity
I8N72_RS18525	COG0693	protein deglycase activity
I8N72_RS18530	COG2851	Citrate transporter
I8N72_RS18535	COG2273	Hydrolase Family 16
I8N72_RS18545	COG2270	Major facilitator Superfamily
I8N72_RS18550	COG0513	Belongs to the DEAD box helicase family
I8N72_RS18630	COG0697	spore germination
I8N72_RS18635	COG0589	response to stress
I8N72_RS18645	COG0494	nUDIX hydrolase
I8N72_RS18650	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N72_RS18675	COG0010	Belongs to the arginase family
I8N72_RS18680	COG0833	amino acid
I8N72_RS18685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I8N72_RS18690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N72_RS18700	COG2390	Transcriptional regulator
I8N72_RS18705	COG0561	phosphatase activity
I8N72_RS18735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N72_RS18740	COG5294	Protein conserved in bacteria
I8N72_RS18745	COG0577	efflux transmembrane transporter activity
I8N72_RS18750	COG1136	(ABC) transporter
I8N72_RS18755	COG2205	protein histidine kinase activity
I8N72_RS18760	COG0745	RESPONSE REGULATOR receiver
I8N72_RS18775	COG1082	Xylose isomerase domain protein TIM barrel
I8N72_RS18785	COG2814	Major facilitator Superfamily
I8N72_RS18815	COG1349	DNA-binding transcription factor activity
I8N72_RS18820	COG0667	Aldo Keto reductase
I8N72_RS18825	COG2814	Major facilitator Superfamily
I8N72_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS18840	COG2197	response regulator
I8N72_RS18845	COG4585	Histidine kinase
I8N72_RS18850	COG3239	Fatty acid desaturase
I8N72_RS18855	COG1309	transcriptional regulator
I8N72_RS18860	COG1012	belongs to the aldehyde dehydrogenase family
I8N72_RS18865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8N72_RS18875	COG0640	Transcriptional regulator
I8N72_RS18880	COG2814	Major facilitator Superfamily
I8N72_RS18885	COG1714	RDD family
I8N72_RS18895	COG0450	alkyl hydroperoxide reductase
I8N72_RS18900	COG3634	alkyl hydroperoxide reductase activity
I8N72_RS18905	COG1113	amino acid transport
I8N72_RS18915	COG2080	2 iron, 2 sulfur cluster binding
I8N72_RS18930	COG2068	MobA-Related Protein
I8N72_RS18935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I8N72_RS18995	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I8N72_RS19000	COG0667	Aldo Keto reductase
I8N72_RS19005	COG0456	acetyltransferase
I8N72_RS19010	COG0457	Tetratricopeptide repeat
I8N72_RS19015	COG0010	Belongs to the arginase family
I8N72_RS19020	COG0833	amino acid
I8N72_RS19025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N72_RS19030	COG5658	integral membrane protein
I8N72_RS19035	COG0640	Transcriptional regulator
I8N72_RS19040	COG3829	transcription factor binding
I8N72_RS19050	COG0488	(ABC) transporter
I8N72_RS19065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N72_RS19070	COG5002	protein histidine kinase activity
I8N72_RS19070	COG3850	Histidine kinase
I8N72_RS19080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N72_RS19085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I8N72_RS19090	COG4853	Protein conserved in bacteria
I8N72_RS19095	COG4863	YycH protein
I8N72_RS19100	COG5002	protein histidine kinase activity
I8N72_RS19105	COG0745	RESPONSE REGULATOR receiver
I8N72_RS19135	COG0346	lactoylglutathione lyase activity
I8N72_RS19140	COG0305	Participates in initiation and elongation during chromosome replication
I8N72_RS19155	COG3093	addiction module antidote protein HigA
I8N72_RS19160	COG0297	glycogen (starch) synthase activity
I8N72_RS19170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I8N72_RS19175	COG0438	transferase activity, transferring glycosyl groups
I8N72_RS19185	COG0515	serine threonine protein kinase
I8N72_RS19195	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I8N72_RS19200	COG4241	membrane
I8N72_RS19210	COG5577	PFAM Coat F domain
I8N72_RS19225	COG0697	spore germination
I8N72_RS19230	COG1621	beta-fructofuranosidase activity
I8N72_RS19235	COG1621	beta-fructofuranosidase activity
I8N72_RS19240	COG1802	Transcriptional regulator
I8N72_RS19245	COG2318	DinB family
I8N72_RS19250	COG2211	Major facilitator Superfamily
I8N72_RS19260	COG0778	Nitroreductase
I8N72_RS19265	COG1846	Transcriptional regulator
I8N72_RS19270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N72_RS19275	COG1846	Transcriptional regulator
I8N72_RS19300	COG0583	DNA-binding transcription factor activity
I8N72_RS19305	COG1028	Short-chain dehydrogenase reductase Sdr
I8N72_RS19310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N72_RS19315	COG0697	spore germination
I8N72_RS19320	COG1090	epimerase
I8N72_RS19330	COG1959	2 iron, 2 sulfur cluster binding
I8N72_RS19335	COG1396	sequence-specific DNA binding
I8N72_RS19345	COG1331	Highly conserved protein containing a thioredoxin domain
I8N72_RS19350	COG1266	CAAX protease self-immunity
I8N72_RS19355	COG0477	Major facilitator Superfamily
I8N72_RS19355	COG2814	Major facilitator Superfamily
I8N72_RS19360	COG0346	lactoylglutathione lyase activity
I8N72_RS19365	COG1609	Transcriptional regulator
I8N72_RS19370	COG0708	Exodeoxyribonuclease III
I8N72_RS19375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N72_RS19380	COG2169	Transcriptional regulator
I8N72_RS19390	COG0629	single-stranded DNA binding
I8N72_RS19400	COG0012	GTP binding
I8N72_RS19405	COG0243	molybdopterin cofactor binding
I8N72_RS19410	COG4481	Protein conserved in bacteria
I8N72_RS19415	COG3949	Membrane
I8N72_RS19430	COG1475	DNA binding
I8N72_RS19435	COG1192	Involved in chromosome partitioning
I8N72_RS19460	COG1847	R3H domain protein
I8N72_RS19465	COG0706	membrane insertase activity