locus-tag	class	description
I8N73_RS00010	COG0592	DNA-directed DNA polymerase activity
I8N73_RS00015	COG2501	S4 domain
I8N73_RS00030	COG0187	DNA topoisomerase II activity
I8N73_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N73_RS00070	COG0516	GMP reductase activity
I8N73_RS00070	COG0517	IMP dehydrogenase activity
I8N73_RS00075	COG1686	Belongs to the peptidase S11 family
I8N73_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
I8N73_RS00105	COG1428	Deoxynucleoside kinase
I8N73_RS00110	COG1428	Deoxynucleoside kinase
I8N73_RS00115	COG3858	chitin binding
I8N73_RS00115	COG1388	LysM domain
I8N73_RS00120	COG1335	isochorismatase
I8N73_RS00125	COG0590	tRNA wobble adenosine to inosine editing
I8N73_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8N73_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I8N73_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I8N73_RS00195	COG3853	Toxic anion resistance protein (TelA)
I8N73_RS00200	COG1982	Orn Lys Arg decarboxylase major
I8N73_RS00210	COG3870	Protein conserved in bacteria
I8N73_RS00215	COG1728	Protein conserved in bacteria
I8N73_RS00220	COG0470	DNA polymerase III
I8N73_RS00225	COG1774	PSP1 C-terminal conserved region
I8N73_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I8N73_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I8N73_RS00250	COG2002	toxin-antitoxin pair type II binding
I8N73_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_RS00260	COG0084	hydrolase, TatD family'
I8N73_RS00265	COG3583	domain protein
I8N73_RS00265	COG3584	3D domain protein
I8N73_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N73_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8N73_RS00285	COG4466	Protein conserved in bacteria
I8N73_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N73_RS00305	COG0251	oxidation-reduction process
I8N73_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8N73_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I8N73_RS00345	COG2002	toxin-antitoxin pair type II binding
I8N73_RS00350	COG2244	polysaccharide biosynthetic process
I8N73_RS00355	COG3956	TIGRFAM MazG family protein
I8N73_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I8N73_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I8N73_RS00380	COG1098	S1 RNA binding domain
I8N73_RS00395	COG2208	phosphoserine phosphatase activity
I8N73_RS00400	COG2304	oxidoreductase activity
I8N73_RS00405	COG0515	serine threonine protein kinase
I8N73_RS00410	COG0037	tRNA processing
I8N73_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I8N73_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8N73_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N73_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N73_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
I8N73_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8N73_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8N73_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8N73_RS00475	COG1396	sequence-specific DNA binding
I8N73_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N73_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8N73_RS00565	COG4463	regulation of RNA biosynthetic process
I8N73_RS00570	COG3880	PFAM UvrB UvrC protein
I8N73_RS00580	COG0542	response to heat
I8N73_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I8N73_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I8N73_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
I8N73_RS00615	COG1045	serine acetyltransferase
I8N73_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I8N73_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N73_RS00635	COG3688	RNA-binding protein containing a PIN domain
I8N73_RS00640	COG1595	DNA-templated transcription, initiation
I8N73_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N73_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
I8N73_RS00680	COG2813	Specifically methylates the guanine in position
I8N73_RS00695	COG1358	cellular component organization or biogenesis
I8N73_RS00720	COG0596	Alpha beta hydrolase
I8N73_RS00830	COG0201	protein transport
I8N73_RS00840	COG0024	Methionine aminopeptidase
I8N73_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8N73_RS00875	COG1122	ATPase activity
I8N73_RS00880	COG1122	ATPase activity
I8N73_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N73_RS00905	COG2226	methyltransferase
I8N73_RS00910	COG2318	DinB family
I8N73_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS00925	COG0489	protein tyrosine kinase activity
I8N73_RS00935	COG2194	sulfuric ester hydrolase activity
I8N73_RS00940	COG0726	polysaccharide deacetylase
I8N73_RS00980	COG3299	homolog of phage Mu protein gp47
I8N73_RS00985	COG3778	Protein conserved in bacteria
I8N73_RS01025	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS01025	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS01035	COG5444	nuclease activity
I8N73_RS01060	COG0457	Tetratricopeptide repeat
I8N73_RS01070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8N73_RS01105	COG0738	Major facilitator superfamily
I8N73_RS01110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS01125	COG0659	secondary active sulfate transmembrane transporter activity
I8N73_RS01130	COG0385	Bile acid
I8N73_RS01135	COG2819	hydrolase of the alpha beta superfamily
I8N73_RS01140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_RS01155	COG2207	Transcriptional regulator
I8N73_RS01155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_RS01160	COG3876	Protein conserved in bacteria
I8N73_RS01165	COG1472	Belongs to the glycosyl hydrolase 3 family
I8N73_RS01170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_RS01175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS01175	COG1263	PTS System
I8N73_RS01185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS01190	COG1683	Conserved Protein
I8N73_RS01220	COG1595	DNA-templated transcription, initiation
I8N73_RS01225	COG5662	AntiSigma factor
I8N73_RS01230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N73_RS01235	COG4856	YbbR-like protein
I8N73_RS01275	COG1346	cytolysis
I8N73_RS01280	COG1380	Effector of murein hydrolase LrgA
I8N73_RS01285	COG1846	Transcriptional regulator
I8N73_RS01290	COG1113	amino acid transport
I8N73_RS01295	COG1011	Hydrolase
I8N73_RS01300	COG4585	Histidine kinase
I8N73_RS01305	COG2197	response regulator
I8N73_RS01310	COG1131	(ABC) transporter
I8N73_RS01330	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N73_RS01350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS01350	COG4221	oxidoreductase activity
I8N73_RS01350	COG3321	synthase
I8N73_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS01355	COG3321	synthase
I8N73_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS01355	COG0300	oxidoreductase activity
I8N73_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS01355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS01395	COG0531	amino acid
I8N73_RS01405	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_RS01410	COG2271	Major facilitator Superfamily
I8N73_RS01420	COG2368	4-hydroxyphenylacetate
I8N73_RS01430	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS01445	COG0371	Dehydrogenase
I8N73_RS01455	COG1183	phosphatidylcholine synthase activity
I8N73_RS01460	COG0586	Pfam SNARE associated Golgi protein
I8N73_RS01465	COG0688	phosphatidylethanolamine metabolic process
I8N73_RS01480	COG1301	dicarboxylic acid transport
I8N73_RS01485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS01490	COG0833	amino acid
I8N73_RS01495	COG2040	homocysteine
I8N73_RS01500	COG1115	amino acid carrier protein
I8N73_RS01505	COG2066	Belongs to the glutaminase family
I8N73_RS01510	COG4191	Histidine kinase
I8N73_RS01515	COG0784	Response regulator, receiver
I8N73_RS01530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_RS01535	COG0778	Nitroreductase
I8N73_RS01540	COG0346	lactoylglutathione lyase activity
I8N73_RS01545	COG2259	Doxx family
I8N73_RS01550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS01560	COG3773	Cell wall hydrolase
I8N73_RS01565	COG3540	Alkaline phosphatase
I8N73_RS01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N73_RS01575	COG0805	protein transport
I8N73_RS01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N73_RS01590	COG0477	Major facilitator Superfamily
I8N73_RS01595	COG1309	transcriptional regulator
I8N73_RS01600	COG0252	asparaginase activity
I8N73_RS01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I8N73_RS01610	COG3012	SEC-C Motif Domain Protein
I8N73_RS01610	COG1405	negative regulation of cell septum assembly
I8N73_RS01615	COG0667	Aldo Keto reductase
I8N73_RS01625	COG1595	DNA-templated transcription, initiation
I8N73_RS01630	COG1595	DNA-templated transcription, initiation
I8N73_RS01635	COG1876	peptidase activity
I8N73_RS01640	COG0457	Tetratricopeptide repeat
I8N73_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS01650	COG0366	Alpha amylase catalytic
I8N73_RS01655	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8N73_RS01660	COG1121	(ABC) transporter
I8N73_RS01665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N73_RS01670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS01675	COG2310	stress, protein
I8N73_RS01680	COG2310	stress, protein
I8N73_RS01685	COG2310	stress, protein
I8N73_RS01690	COG0861	Integral membrane protein TerC family
I8N73_RS01700	COG3853	Toxic anion resistance protein (TelA)
I8N73_RS01705	COG0477	Major facilitator Superfamily
I8N73_RS01710	COG0517	IMP dehydrogenase activity
I8N73_RS01710	COG4175	Glycine betaine
I8N73_RS01715	COG4176	ABC-type proline glycine betaine transport system permease component
I8N73_RS01720	COG2113	Glycine betaine
I8N73_RS01725	COG1473	amidohydrolase
I8N73_RS01730	COG1288	antiporter activity
I8N73_RS01740	COG0366	Alpha amylase catalytic
I8N73_RS01750	COG2814	Major facilitator Superfamily
I8N73_RS01755	COG1846	Transcriptional regulator
I8N73_RS01760	COG1280	lysine exporter protein (LysE YggA)
I8N73_RS01765	COG3403	YqcI/YcgG family
I8N73_RS01770	COG1113	amino acid transport
I8N73_RS01775	COG3665	Urea carboxylase-associated protein
I8N73_RS01795	COG1082	Xylose isomerase domain protein TIM barrel
I8N73_RS01800	COG2271	Major facilitator Superfamily
I8N73_RS01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8N73_RS01810	COG3458	cephalosporin-C deacetylase activity
I8N73_RS01815	COG3541	Predicted nucleotidyltransferase
I8N73_RS01820	COG0506	proline dehydrogenase activity
I8N73_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS01830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_RS01835	COG2508	Transcriptional regulator
I8N73_RS01845	COG1587	Uroporphyrinogen-III synthase
I8N73_RS01845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N73_RS01850	COG2146	nitrite reductase [NAD(P)H] activity
I8N73_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N73_RS01860	COG0243	molybdopterin cofactor binding
I8N73_RS01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N73_RS01870	COG2223	nitrite transmembrane transporter activity
I8N73_RS01875	COG0523	cobalamin synthesis protein
I8N73_RS01880	COG1063	alcohol dehydrogenase
I8N73_RS01885	COG1714	RDD family
I8N73_RS01895	COG2723	6-phospho-beta-galactosidase activity
I8N73_RS01905	COG3209	COG3209 Rhs family protein
I8N73_RS01910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I8N73_RS01915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I8N73_RS01920	COG1733	regulation of RNA biosynthetic process
I8N73_RS01925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS01930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS01935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS01940	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N73_RS01955	COG0697	spore germination
I8N73_RS01960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS01970	COG2364	Membrane
I8N73_RS01975	COG1126	abc transporter atp-binding protein
I8N73_RS01980	COG0765	amino acid transport
I8N73_RS01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS01990	COG0583	DNA-binding transcription factor activity
I8N73_RS01995	COG0163	prenyltransferase activity
I8N73_RS02000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I8N73_RS02015	COG3104	oligopeptide transport
I8N73_RS02020	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_RS02030	COG0697	spore germination
I8N73_RS02040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N73_RS02045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS02050	COG0456	acetyltransferase
I8N73_RS02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS02060	COG0765	amino acid transport
I8N73_RS02065	COG1126	abc transporter atp-binding protein
I8N73_RS02070	COG1473	amidohydrolase
I8N73_RS02075	COG2079	MmgE PrpD family protein
I8N73_RS02080	COG1136	(ABC) transporter
I8N73_RS02085	COG0577	efflux transmembrane transporter activity
I8N73_RS02090	COG0745	RESPONSE REGULATOR receiver
I8N73_RS02095	COG3850	Histidine kinase
I8N73_RS02095	COG5002	protein histidine kinase activity
I8N73_RS02100	COG0457	Tetratricopeptide repeat
I8N73_RS02115	COG0527	aspartate kinase activity
I8N73_RS02120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS02125	COG4605	iron ion homeostasis
I8N73_RS02130	COG4604	ABC transporter, ATP-binding protein
I8N73_RS02135	COG4607	ABC-type enterochelin transport system periplasmic component
I8N73_RS02140	COG2814	Major facilitator Superfamily
I8N73_RS02145	COG1309	transcriptional regulator
I8N73_RS02150	COG0778	Nitroreductase
I8N73_RS02155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N73_RS02160	COG0640	Transcriptional regulator
I8N73_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS02170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS02180	COG4975	Glucose uptake
I8N73_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS02190	COG4549	nuclear export factor GLE1
I8N73_RS02195	COG2372	response to copper ion
I8N73_RS02195	COG1276	copper resistance
I8N73_RS02200	COG1349	DNA-binding transcription factor activity
I8N73_RS02210	COG2213	PTS system mannitol-specific
I8N73_RS02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS02225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I8N73_RS02235	COG0561	phosphatase activity
I8N73_RS02245	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N73_RS02255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8N73_RS02260	COG1984	allophanate hydrolase subunit 2
I8N73_RS02265	COG1414	Transcriptional regulator
I8N73_RS02270	COG2755	lipolytic protein G-D-S-L family
I8N73_RS02280	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_RS02285	COG0768	penicillin binding
I8N73_RS02290	COG4989	oxidoreductase activity
I8N73_RS02295	COG3711	transcriptional antiterminator
I8N73_RS02300	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS02310	COG1917	Cupin 2, conserved barrel domain protein
I8N73_RS02315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS02320	COG3871	stress protein (general stress protein 26)
I8N73_RS02330	COG2814	Major facilitator Superfamily
I8N73_RS02335	COG1522	sequence-specific DNA binding
I8N73_RS02340	COG0551	DNA topoisomerase type I activity
I8N73_RS02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N73_RS02345	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I8N73_RS02350	COG3706	GGDEF domain
I8N73_RS02355	COG5298	Protein conserved in bacteria
I8N73_RS02360	COG1215	transferase activity, transferring glycosyl groups
I8N73_RS02370	COG0531	amino acid
I8N73_RS02380	COG0028	Belongs to the TPP enzyme family
I8N73_RS02405	COG1794	racemase activity, acting on amino acids and derivatives
I8N73_RS02435	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N73_RS02445	COG4876	unkown
I8N73_RS02455	COG2076	Multidrug Resistance protein
I8N73_RS02460	COG2217	Heavy metal translocating P-type atpase
I8N73_RS02465	COG3729	General stress protein
I8N73_RS02470	COG0662	Cupin 2, conserved barrel domain protein
I8N73_RS02475	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_RS02480	COG3546	catalase activity
I8N73_RS02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I8N73_RS02490	COG3290	protein histidine kinase activity
I8N73_RS02495	COG4565	transcriptional regulatory protein
I8N73_RS02500	COG1301	dicarboxylic acid transport
I8N73_RS02505	COG0628	permease
I8N73_RS02510	COG1131	(ABC) transporter
I8N73_RS02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_RS02525	COG1960	acyl-CoA dehydrogenase activity
I8N73_RS02540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_RS02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I8N73_RS02560	COG0513	Belongs to the DEAD box helicase family
I8N73_RS02565	COG3402	PFAM membrane-flanked domain
I8N73_RS02570	COG3428	Bacterial PH domain
I8N73_RS02575	COG0705	Rhomboid family
I8N73_RS02585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I8N73_RS02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N73_RS02595	COG0864	Transcriptional regulator
I8N73_RS02600	COG2337	Toxic component of a toxin-antitoxin (TA) module
I8N73_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS02615	COG2172	sigma factor antagonist activity
I8N73_RS02620	COG2208	phosphoserine phosphatase activity
I8N73_RS02625	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS02635	COG1191	sigma factor activity
I8N73_RS02640	COG2208	phosphoserine phosphatase activity
I8N73_RS02645	COG2183	response to ionizing radiation
I8N73_RS02695	COG0582	viral genome integration into host DNA
I8N73_RS02700	COG2856	Zn peptidase
I8N73_RS02705	COG1396	sequence-specific DNA binding
I8N73_RS02735	COG1674	ftsk spoiiie
I8N73_RS02740	COG2946	Replication initiation factor
I8N73_RS02770	COG0433	COG0433 Predicted ATPase
I8N73_RS02780	COG5644	endopeptidase inhibitor activity
I8N73_RS02785	COG0791	NLP P60 protein
I8N73_RS02785	COG0741	lytic transglycosylase activity
I8N73_RS02800	COG0457	Tetratricopeptide repeat
I8N73_RS02810	COG3403	YqcI/YcgG family
I8N73_RS02815	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_RS02825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I8N73_RS02830	COG1522	sequence-specific DNA binding
I8N73_RS02845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N73_RS02850	COG0477	Major facilitator Superfamily
I8N73_RS02855	COG1846	Transcriptional regulator
I8N73_RS02865	COG2030	dehydratase
I8N73_RS02880	COG1959	2 iron, 2 sulfur cluster binding
I8N73_RS02885	COG2910	NAD(P)H-binding
I8N73_RS02890	COG3239	Fatty acid desaturase
I8N73_RS02900	COG1278	Cold shock
I8N73_RS02905	COG1329	Transcriptional regulator
I8N73_RS02910	COG1794	racemase activity, acting on amino acids and derivatives
I8N73_RS02925	COG3621	Patatin-like phospholipase
I8N73_RS02935	COG0662	Cupin 2, conserved barrel domain protein
I8N73_RS02950	COG0277	FAD linked oxidase domain protein
I8N73_RS02980	COG2318	DinB family
I8N73_RS03010	COG0351	phosphomethylpyrimidine kinase
I8N73_RS03025	COG1064	alcohol dehydrogenase
I8N73_RS03030	COG0789	Transcriptional regulator
I8N73_RS03040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS03055	COG2814	Major facilitator Superfamily
I8N73_RS03060	COG1309	transcriptional regulator
I8N73_RS03065	COG0697	spore germination
I8N73_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS03075	COG5577	PFAM Coat F domain
I8N73_RS03085	COG1063	alcohol dehydrogenase
I8N73_RS03090	COG5577	PFAM Coat F domain
I8N73_RS03100	COG4585	Histidine kinase
I8N73_RS03105	COG2197	response regulator
I8N73_RS03110	COG2409	Drug exporters of the RND superfamily
I8N73_RS03115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I8N73_RS03120	COG0488	(ABC) transporter
I8N73_RS03125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS03130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS03140	COG2814	Major facilitator Superfamily
I8N73_RS03150	COG0456	acetyltransferase
I8N73_RS03160	COG1051	belongs to the nudix hydrolase family
I8N73_RS03165	COG2226	methyltransferase
I8N73_RS03170	COG0473	3-isopropylmalate dehydrogenase activity
I8N73_RS03175	COG1802	Transcriptional regulator
I8N73_RS03180	COG1819	glycosyl
I8N73_RS03195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_RS03205	COG1388	LysM domain
I8N73_RS03210	COG2814	Major facilitator Superfamily
I8N73_RS03215	COG2188	Transcriptional regulator
I8N73_RS03220	COG2186	Transcriptional regulator
I8N73_RS03225	COG2807	transmembrane transport
I8N73_RS03230	COG2076	Multidrug Resistance protein
I8N73_RS03235	COG2076	Multidrug Resistance protein
I8N73_RS03240	COG1309	transcriptional regulator
I8N73_RS03245	COG0531	amino acid
I8N73_RS03255	COG3832	glyoxalase III activity
I8N73_RS03260	COG0604	alcohol dehydrogenase
I8N73_RS03265	COG2814	Major facilitator Superfamily
I8N73_RS03305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8N73_RS03310	COG0802	atpase or kinase
I8N73_RS03315	COG1214	PFAM Peptidase M22, glycoprotease
I8N73_RS03320	COG0456	acetyltransferase
I8N73_RS03325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8N73_RS03330	COG0488	(ABC) transporter
I8N73_RS03345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N73_RS03350	COG0805	protein transport
I8N73_RS03360	COG1266	CAAX protease self-immunity
I8N73_RS03375	COG0745	RESPONSE REGULATOR receiver
I8N73_RS03390	COG3290	protein histidine kinase activity
I8N73_RS03470	COG0457	Tetratricopeptide repeat
I8N73_RS03475	COG1063	alcohol dehydrogenase
I8N73_RS03480	COG2211	Major facilitator Superfamily
I8N73_RS03485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_RS03495	COG1842	Phage shock protein A
I8N73_RS03500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N73_RS03505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I8N73_RS03510	COG4260	virion core protein, lumpy skin disease virus
I8N73_RS03515	COG2755	lipolytic protein G-D-S-L family
I8N73_RS03515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8N73_RS03525	COG1595	DNA-templated transcription, initiation
I8N73_RS03530	COG1063	alcohol dehydrogenase
I8N73_RS03535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I8N73_RS03540	COG0823	Involved in the tonB-independent uptake of proteins
I8N73_RS03555	COG2132	Multicopper oxidase
I8N73_RS03560	COG1113	amino acid transport
I8N73_RS03565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_RS03570	COG0714	Associated with various cellular activities
I8N73_RS03575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I8N73_RS03580	COG1305	Transglutaminase-like
I8N73_RS03605	COG2252	PERMEase
I8N73_RS03610	COG3064	Membrane
I8N73_RS03630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I8N73_RS03635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I8N73_RS03640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8N73_RS03645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8N73_RS03650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8N73_RS03665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I8N73_RS03675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I8N73_RS03680	COG0138	bifunctional purine biosynthesis protein purh
I8N73_RS03685	COG0151	Belongs to the GarS family
I8N73_RS03695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8N73_RS03700	COG1470	cell adhesion involved in biofilm formation
I8N73_RS03705	COG4496	protein, YerC YecD
I8N73_RS03710	COG0069	glutamate synthase activity
I8N73_RS03720	COG0210	DNA helicase
I8N73_RS03730	COG4851	CamS sex pheromone cAM373 precursor
I8N73_RS03735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_RS03740	COG1285	pathogenesis
I8N73_RS03745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_RS03765	COG1309	transcriptional regulator
I8N73_RS03770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8N73_RS03775	COG1597	lipid kinase activity
I8N73_RS03780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N73_RS03790	COG1131	(ABC) transporter
I8N73_RS03810	COG5444	nuclease activity
I8N73_RS03830	COG5444	nuclease activity
I8N73_RS03855	COG3546	catalase activity
I8N73_RS03860	COG0454	-acetyltransferase
I8N73_RS03870	COG2323	membrane
I8N73_RS03875	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_RS03880	COG0346	lactoylglutathione lyase activity
I8N73_RS03885	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS03890	COG5583	Uncharacterized small protein (DUF2292)
I8N73_RS03895	COG0196	riboflavin kinase activity
I8N73_RS03900	COG0670	Belongs to the BI1 family
I8N73_RS03905	COG1846	Transcriptional regulator
I8N73_RS03910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N73_RS03920	COG2124	cytochrome p450
I8N73_RS03920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_RS03935	COG1131	(ABC) transporter
I8N73_RS03945	COG1368	sulfuric ester hydrolase activity
I8N73_RS03950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8N73_RS03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS03960	COG1442	glycosyl transferase family 8
I8N73_RS03965	COG1216	Glycosyl transferase, family 2
I8N73_RS03970	COG1442	glycosyl transferase family 8
I8N73_RS03975	COG2223	nitrite transmembrane transporter activity
I8N73_RS03980	COG0531	amino acid
I8N73_RS03985	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS03990	COG0840	transmembrane signaling receptor activity
I8N73_RS03995	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS04000	COG0463	Glycosyl transferase, family 2
I8N73_RS04000	COG0457	Tetratricopeptide repeat
I8N73_RS04005	COG0488	(ABC) transporter
I8N73_RS04010	COG0789	Transcriptional regulator
I8N73_RS04015	COG2814	Major facilitator Superfamily
I8N73_RS04020	COG0488	(ABC) transporter
I8N73_RS04025	COG0513	Belongs to the DEAD box helicase family
I8N73_RS04030	COG0456	acetyltransferase
I8N73_RS04035	COG2130	NADP-dependent
I8N73_RS04050	COG3866	Pectate lyase
I8N73_RS04055	COG0471	metal ion transport
I8N73_RS04075	COG0745	RESPONSE REGULATOR receiver
I8N73_RS04075	COG2972	Histidine kinase
I8N73_RS04080	COG3279	Response regulator of the LytR AlgR family
I8N73_RS04090	COG3764	Sortase (surface protein transpeptidase)
I8N73_RS04095	COG3290	protein histidine kinase activity
I8N73_RS04100	COG4565	transcriptional regulatory protein
I8N73_RS04105	COG3181	Tripartite tricarboxylate transporter family receptor
I8N73_RS04110	COG2851	Citrate transporter
I8N73_RS04115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS04120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I8N73_RS04130	COG2258	MOSC domain
I8N73_RS04150	COG0024	Methionine aminopeptidase
I8N73_RS04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS04155	COG1263	PTS System
I8N73_RS04165	COG1368	sulfuric ester hydrolase activity
I8N73_RS04175	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_RS04190	COG1263	PTS System
I8N73_RS04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS04195	COG0366	Alpha amylase catalytic
I8N73_RS04200	COG2188	Transcriptional regulator
I8N73_RS04205	COG0778	Nitroreductase
I8N73_RS04220	COG0737	Belongs to the 5'-nucleotidase family
I8N73_RS04225	COG0693	protein deglycase activity
I8N73_RS04230	COG1609	Transcriptional regulator
I8N73_RS04245	COG2814	Major facilitator Superfamily
I8N73_RS04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N73_RS04260	COG4980	gas vesicle protein
I8N73_RS04265	COG1295	ribonuclease BN
I8N73_RS04270	COG0477	Major facilitator Superfamily
I8N73_RS04275	COG0387	Pfam Sodium calcium exchanger
I8N73_RS04285	COG0668	transmembrane transport
I8N73_RS04290	COG0535	radical SAM domain protein
I8N73_RS04300	COG0726	polysaccharide deacetylase
I8N73_RS04305	COG2084	Dehydrogenase
I8N73_RS04315	COG0598	Magnesium transport protein CorA
I8N73_RS04320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I8N73_RS04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N73_RS04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N73_RS04345	COG4637	Psort location Cytoplasmic, score
I8N73_RS04350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_RS04355	COG0022	dehydrogenase e1 component
I8N73_RS04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_RS04365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_RS04370	COG3284	Transcriptional regulator
I8N73_RS04380	COG1486	melibiose metabolic process
I8N73_RS04385	COG1737	Transcriptional regulator
I8N73_RS04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS04390	COG1263	PTS System
I8N73_RS04395	COG1132	(ABC) transporter
I8N73_RS04400	COG1132	(ABC) transporter
I8N73_RS04405	COG2259	Doxx family
I8N73_RS04410	COG2514	catechol 2,3-dioxygenase activity
I8N73_RS04420	COG1695	Transcriptional regulator
I8N73_RS04425	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_RS04430	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I8N73_RS04435	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_RS04435	COG3848	Pyruvate phosphate dikinase
I8N73_RS04440	COG2732	(Barnase) inhibitor
I8N73_RS04445	COG2318	DinB family
I8N73_RS04450	COG2814	Major facilitator Superfamily
I8N73_RS04455	COG1846	Transcriptional regulator
I8N73_RS04460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I8N73_RS04460	COG0392	lysyltransferase activity
I8N73_RS04465	COG0384	phenazine biosynthesis protein PhzF
I8N73_RS04470	COG0778	Nitroreductase
I8N73_RS04485	COG1090	epimerase
I8N73_RS04500	COG2814	Major facilitator Superfamily
I8N73_RS04510	COG3591	Belongs to the peptidase S1B family
I8N73_RS04525	COG3103	Sh3 type 3 domain protein
I8N73_RS04530	COG5658	integral membrane protein
I8N73_RS04535	COG0596	Alpha beta hydrolase
I8N73_RS04540	COG0463	Glycosyl transferase, family 2
I8N73_RS04545	COG4485	Bacterial membrane protein, YfhO
I8N73_RS04550	COG1988	membrane-bound metal-dependent
I8N73_RS04555	COG1194	a g-specific adenine glycosylase
I8N73_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS04585	COG1132	(ABC) transporter
I8N73_RS04590	COG4129	membrane
I8N73_RS04600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I8N73_RS04605	COG0735	belongs to the Fur family
I8N73_RS04715	COG1757	Na H antiporter
I8N73_RS04720	COG3340	Belongs to the peptidase S51 family
I8N73_RS04730	COG0277	FAD linked oxidase domain protein
I8N73_RS04740	COG0747	negative chemotaxis
I8N73_RS04745	COG0601	transmembrane transport
I8N73_RS04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_RS04755	COG0444	Belongs to the ABC transporter superfamily
I8N73_RS04760	COG4608	Belongs to the ABC transporter superfamily
I8N73_RS04765	COG0753	catalase activity
I8N73_RS04775	COG1116	anion transmembrane transporter activity
I8N73_RS04780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N73_RS04785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N73_RS04805	COG1476	TRANSCRIPTIONal
I8N73_RS04815	COG3382	B3 4 domain protein
I8N73_RS04820	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I8N73_RS04830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I8N73_RS04835	COG0789	Transcriptional regulator
I8N73_RS04840	COG1664	Polymer-forming cytoskeletal
I8N73_RS04845	COG1664	Polymer-forming cytoskeletal
I8N73_RS04850	COG2766	serine protein kinase
I8N73_RS04860	COG1846	Transcriptional regulator
I8N73_RS04865	COG1566	PFAM secretion protein HlyD family protein
I8N73_RS04870	COG2814	Major facilitator Superfamily
I8N73_RS04875	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N73_RS04890	COG1725	Transcriptional regulator
I8N73_RS04895	COG1131	(ABC) transporter
I8N73_RS04900	COG1131	(ABC) transporter
I8N73_RS04905	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_RS04910	COG1278	Cold shock
I8N73_RS04915	COG1464	Belongs to the NlpA lipoprotein family
I8N73_RS04920	COG3706	GGDEF domain
I8N73_RS04925	COG1823	symporter activity
I8N73_RS04945	COG5577	PFAM Coat F domain
I8N73_RS04950	COG4085	toxin activity
I8N73_RS04950	COG0737	Belongs to the 5'-nucleotidase family
I8N73_RS04950	COG1525	nuclease
I8N73_RS04955	COG3764	Sortase (surface protein transpeptidase)
I8N73_RS04960	COG0564	pseudouridine synthase activity
I8N73_RS04970	COG0517	IMP dehydrogenase activity
I8N73_RS04975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8N73_RS04980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N73_RS04980	COG3153	acetyltransferase
I8N73_RS04985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_RS04990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I8N73_RS04995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8N73_RS05005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8N73_RS05010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8N73_RS05015	COG4585	Histidine kinase
I8N73_RS05015	COG2203	Gaf domain
I8N73_RS05020	COG2197	response regulator
I8N73_RS05025	COG0431	NADPH-dependent FMN reductase
I8N73_RS05040	COG0791	NLP P60 protein
I8N73_RS05040	COG1388	LysM domain
I8N73_RS05045	COG1959	2 iron, 2 sulfur cluster binding
I8N73_RS05050	COG0668	transmembrane transport
I8N73_RS05055	COG2719	SpoVR family
I8N73_RS05060	COG1785	Belongs to the alkaline phosphatase family
I8N73_RS05065	COG0791	NLP P60 protein
I8N73_RS05065	COG1388	LysM domain
I8N73_RS05070	COG0583	DNA-binding transcription factor activity
I8N73_RS05075	COG0372	Belongs to the citrate synthase family
I8N73_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS05085	COG0531	amino acid
I8N73_RS05090	COG0733	neurotransmitter:sodium symporter activity
I8N73_RS05105	COG1595	DNA-templated transcription, initiation
I8N73_RS05110	COG0204	Acyl-transferase
I8N73_RS05115	COG1253	flavin adenine dinucleotide binding
I8N73_RS05120	COG0789	Transcriptional regulator
I8N73_RS05125	COG0436	Aminotransferase
I8N73_RS05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N73_RS05135	COG1253	flavin adenine dinucleotide binding
I8N73_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N73_RS05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N73_RS05150	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_RS05160	COG0668	transmembrane transport
I8N73_RS05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8N73_RS05170	COG0726	polysaccharide deacetylase
I8N73_RS05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS05180	COG3226	Transcriptional regulator
I8N73_RS05190	COG0589	response to stress
I8N73_RS05195	COG1132	(ABC) transporter
I8N73_RS05200	COG1132	(ABC) transporter
I8N73_RS05205	COG0702	epimerase
I8N73_RS05220	COG0189	ligase activity
I8N73_RS05225	COG0189	ligase activity
I8N73_RS05240	COG4335	DNA alkylation repair
I8N73_RS05245	COG0561	phosphatase activity
I8N73_RS05250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N73_RS05260	COG0475	glutathione-regulated potassium exporter activity
I8N73_RS05265	COG0490	domain, Protein
I8N73_RS05275	COG1024	Enoyl-CoA hydratase
I8N73_RS05285	COG4152	abc transporter atp-binding protein
I8N73_RS05290	COG1668	transmembrane transport
I8N73_RS05295	COG0420	3'-5' exonuclease activity
I8N73_RS05300	COG4717	serine-type aminopeptidase activity
I8N73_RS05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N73_RS05350	COG4980	gas vesicle protein
I8N73_RS05365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I8N73_RS05370	COG0537	adenosine 5'-monophosphoramidase activity
I8N73_RS05375	COG1131	(ABC) transporter
I8N73_RS05380	COG4473	ABC transporter
I8N73_RS05390	COG1473	amidohydrolase
I8N73_RS05395	COG3069	C4-dicarboxylate transmembrane transporter activity
I8N73_RS05400	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_RS05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_RS05415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8N73_RS05425	COG1309	transcriptional regulator
I8N73_RS05430	COG1511	domain protein
I8N73_RS05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_RS05445	COG1363	Peptidase, m42
I8N73_RS05450	COG1301	dicarboxylic acid transport
I8N73_RS05460	COG1234	tRNA 3'-trailer cleavage
I8N73_RS05465	COG0095	Lipoate-protein ligase
I8N73_RS05470	COG0702	epimerase
I8N73_RS05475	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS05485	COG0501	Belongs to the peptidase M48B family
I8N73_RS05490	COG1404	Belongs to the peptidase S8 family
I8N73_RS05495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8N73_RS05500	COG0406	alpha-ribazole phosphatase activity
I8N73_RS05505	COG0183	Belongs to the thiolase family
I8N73_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS05515	COG1268	BioY protein
I8N73_RS05520	COG0840	transmembrane signaling receptor activity
I8N73_RS05525	COG0723	plastoquinol--plastocyanin reductase activity
I8N73_RS05525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS05540	COG4903	ComK protein
I8N73_RS05550	COG5646	InterPro IPR014922
I8N73_RS05575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_RS05590	COG0398	Pfam SNARE associated Golgi protein
I8N73_RS05595	COG0681	Belongs to the peptidase S26 family
I8N73_RS05600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N73_RS05605	COG1846	Transcriptional regulator
I8N73_RS05610	COG3180	Ammonia monooxygenase
I8N73_RS05615	COG2814	Major facilitator Superfamily
I8N73_RS05625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I8N73_RS05630	COG2323	membrane
I8N73_RS05645	COG0420	3'-5' exonuclease activity
I8N73_RS05650	COG0419	ATPase involved in DNA repair
I8N73_RS05655	COG1403	HNH endonuclease
I8N73_RS05695	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8N73_RS05715	COG0367	asparagine synthase
I8N73_RS05720	COG1562	ergosterol biosynthetic process
I8N73_RS05725	COG0534	Mate efflux family protein
I8N73_RS05730	COG2207	Transcriptional regulator
I8N73_RS05730	COG1917	Cupin 2, conserved barrel domain protein
I8N73_RS05735	COG2318	DinB family
I8N73_RS05740	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N73_RS05745	COG2153	protein acetylation
I8N73_RS05750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I8N73_RS05750	COG0646	methionine synthase
I8N73_RS05760	COG2996	Protein conserved in bacteria
I8N73_RS05765	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_RS05770	COG0840	transmembrane signaling receptor activity
I8N73_RS05775	COG2124	cytochrome p450
I8N73_RS05785	COG1307	EDD domain protein, DegV family
I8N73_RS05790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS05810	COG0561	phosphatase activity
I8N73_RS05815	COG1073	alpha beta
I8N73_RS05820	COG2151	metal-sulfur cluster biosynthetic enzyme
I8N73_RS05830	COG0277	FAD linked oxidase domain protein
I8N73_RS05835	COG2271	Major facilitator Superfamily
I8N73_RS05845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8N73_RS05855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N73_RS05860	COG0505	Belongs to the CarA family
I8N73_RS05865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N73_RS05870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8N73_RS05885	COG2267	carboxylic ester hydrolase activity
I8N73_RS05895	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_RS05910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_RS05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N73_RS05920	COG5504	Zn-dependent protease
I8N73_RS05925	COG0444	Belongs to the ABC transporter superfamily
I8N73_RS05930	COG4608	Belongs to the ABC transporter superfamily
I8N73_RS05940	COG0601	transmembrane transport
I8N73_RS05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_RS05960	COG0180	Tryptophanyl-tRNA synthetase
I8N73_RS05965	COG4166	transmembrane transport
I8N73_RS05970	COG0601	transmembrane transport
I8N73_RS05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_RS05980	COG0444	Belongs to the ABC transporter superfamily
I8N73_RS05985	COG4608	Belongs to the ABC transporter superfamily
I8N73_RS05995	COG0456	acetyltransferase
I8N73_RS06000	COG1393	Belongs to the ArsC family
I8N73_RS06005	COG0861	Integral membrane protein TerC family
I8N73_RS06015	COG4862	establishment of competence for transformation
I8N73_RS06020	COG4469	Competence protein
I8N73_RS06025	COG1164	Oligoendopeptidase f
I8N73_RS06035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N73_RS06040	COG2346	COG2346, Truncated hemoglobins
I8N73_RS06045	COG0741	lytic transglycosylase activity
I8N73_RS06050	COG4116	CYTH
I8N73_RS06060	COG2357	RelA SpoT domain protein
I8N73_RS06065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N73_RS06070	COG0564	pseudouridine synthase activity
I8N73_RS06080	COG0569	domain protein
I8N73_RS06080	COG0475	glutathione-regulated potassium exporter activity
I8N73_RS06085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8N73_RS06090	COG0352	thiamine-phosphate diphosphorylase activity
I8N73_RS06095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_RS06100	COG2104	thiamine diphosphate biosynthetic process
I8N73_RS06110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_RS06115	COG0351	phosphomethylpyrimidine kinase
I8N73_RS06120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8N73_RS06175	COG0210	DNA helicase
I8N73_RS06195	COG1131	(ABC) transporter
I8N73_RS06205	COG2153	protein acetylation
I8N73_RS06215	COG2382	esterase
I8N73_RS06220	COG0626	cystathionine gamma-synthase activity
I8N73_RS06225	COG0626	cystathionine gamma-synthase activity
I8N73_RS06255	COG5444	nuclease activity
I8N73_RS06295	COG0135	phosphoribosylanthranilate isomerase activity
I8N73_RS06305	COG2367	Beta-lactamase
I8N73_RS06310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N73_RS06320	COG1846	Transcriptional regulator
I8N73_RS06330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N73_RS06335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N73_RS06340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N73_RS06345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS06345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS06350	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_RS06375	COG1285	pathogenesis
I8N73_RS06390	COG2205	protein histidine kinase activity
I8N73_RS06400	COG3383	formate dehydrogenase (NAD+) activity
I8N73_RS06405	COG2427	Protein of unknown function (DUF1641)
I8N73_RS06410	COG2124	cytochrome p450
I8N73_RS06415	COG1819	glycosyl
I8N73_RS06425	COG1587	Uroporphyrinogen-III synthase
I8N73_RS06430	COG0390	transport system, permease component
I8N73_RS06435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_RS06440	COG0697	spore germination
I8N73_RS06445	COG4297	protein containing double-stranded beta helix domain
I8N73_RS06455	COG1252	NADH dehydrogenase
I8N73_RS06465	COG2211	Major facilitator Superfamily
I8N73_RS06470	COG1609	Transcriptional regulator
I8N73_RS06475	COG0246	Mannitol dehydrogenase
I8N73_RS06480	COG2721	sulfolactate sulfo-lyase activity
I8N73_RS06485	COG0745	RESPONSE REGULATOR receiver
I8N73_RS06490	COG2205	protein histidine kinase activity
I8N73_RS06490	COG2770	Histidine kinase
I8N73_RS06505	COG0730	response to heat
I8N73_RS06510	COG2318	DinB family
I8N73_RS06515	COG0457	Tetratricopeptide repeat
I8N73_RS06525	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS06525	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS06525	COG1388	LysM domain
I8N73_RS06535	COG4195	phage-related replication protein
I8N73_RS06545	COG2856	Zn peptidase
I8N73_RS06550	COG1396	sequence-specific DNA binding
I8N73_RS06560	COG1522	sequence-specific DNA binding
I8N73_RS06565	COG1484	DNA-dependent DNA replication
I8N73_RS06585	COG1595	DNA-templated transcription, initiation
I8N73_RS06590	COG5484	DNA packaging
I8N73_RS06590	COG3728	DNA packaging
I8N73_RS06595	COG1783	phage Terminase large subunit
I8N73_RS06600	COG5518	Phage portal protein
I8N73_RS06605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I8N73_RS06610	COG4653	Phage capsid family
I8N73_RS06660	COG5412	phage tail tape measure protein
I8N73_RS06660	COG5412	phage tail tape measure protein
I8N73_RS06660	COG3953	SLT domain
I8N73_RS06660	COG3953	SLT domain
I8N73_RS06660	COG3953	SLT domain
I8N73_RS06660	COG5412	phage tail tape measure protein
I8N73_RS06665	COG1652	LysM domain
I8N73_RS06670	COG4193	domain, Protein
I8N73_RS06680	COG3628	GPW Gp25 family protein
I8N73_RS06685	COG3299	homolog of phage Mu protein gp47
I8N73_RS06690	COG3778	Protein conserved in bacteria
I8N73_RS06730	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS06730	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS06745	COG0306	phosphate transporter
I8N73_RS06750	COG1392	Phosphate transport regulator
I8N73_RS06755	COG0531	amino acid
I8N73_RS06760	COG0346	lactoylglutathione lyase activity
I8N73_RS06765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N73_RS06770	COG0463	Glycosyl transferase, family 2
I8N73_RS06780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_RS06785	COG0477	Major facilitator Superfamily
I8N73_RS06790	COG2362	D-Aminopeptidase
I8N73_RS06795	COG0601	transmembrane transport
I8N73_RS06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_RS06805	COG0444	Belongs to the ABC transporter superfamily
I8N73_RS06810	COG4166	transmembrane transport
I8N73_RS06815	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N73_RS06820	COG4948	Mandelate Racemase Muconate Lactonizing
I8N73_RS06825	COG0791	NLP P60 protein
I8N73_RS06830	COG4608	Belongs to the ABC transporter superfamily
I8N73_RS06835	COG2706	6-phosphogluconolactonase activity
I8N73_RS06840	COG1834	amidinotransferase
I8N73_RS06845	COG1607	acyl-coa hydrolase
I8N73_RS06850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS06855	COG2076	Multidrug Resistance protein
I8N73_RS06860	COG2076	Multidrug Resistance protein
I8N73_RS06865	COG0788	formyltetrahydrofolate deformylase activity
I8N73_RS06870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N73_RS06880	COG1764	response to oxidative stress
I8N73_RS06885	COG1846	Transcriptional regulator
I8N73_RS06890	COG1764	response to oxidative stress
I8N73_RS06905	COG0463	Glycosyl transferase, family 2
I8N73_RS06905	COG0457	Tetratricopeptide repeat
I8N73_RS06915	COG2814	Major facilitator Superfamily
I8N73_RS06920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_RS06930	COG1404	Belongs to the peptidase S8 family
I8N73_RS06935	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS06940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N73_RS06945	COG1122	ATPase activity
I8N73_RS06950	COG4721	ABC-type cobalt transport system, permease component
I8N73_RS06955	COG3858	chitin binding
I8N73_RS06955	COG1388	LysM domain
I8N73_RS06965	COG2239	Acts as a magnesium transporter
I8N73_RS06970	COG0789	Transcriptional regulator
I8N73_RS06985	COG1846	Transcriptional regulator
I8N73_RS06990	COG0726	polysaccharide deacetylase
I8N73_RS06995	COG1793	dna ligase
I8N73_RS06995	COG3285	dna ligase
I8N73_RS07000	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8N73_RS07005	COG0586	Pfam SNARE associated Golgi protein
I8N73_RS07010	COG0861	Integral membrane protein TerC family
I8N73_RS07015	COG1191	sigma factor activity
I8N73_RS07040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8N73_RS07045	COG2323	membrane
I8N73_RS07055	COG3594	Acyltransferase
I8N73_RS07060	COG5002	protein histidine kinase activity
I8N73_RS07065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N73_RS07080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N73_RS07085	COG0436	Aminotransferase
I8N73_RS07115	COG3852	Histidine kinase
I8N73_RS07120	COG1846	Transcriptional regulator
I8N73_RS07125	COG1360	Flagellar Motor Protein
I8N73_RS07130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N73_RS07135	COG0542	response to heat
I8N73_RS07140	COG3949	Membrane
I8N73_RS07155	COG0720	synthase
I8N73_RS07160	COG0602	queuosine metabolic process
I8N73_RS07170	COG1733	regulation of RNA biosynthetic process
I8N73_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS07185	COG4641	Protein conserved in bacteria
I8N73_RS07185	COG1388	LysM domain
I8N73_RS07190	COG1388	LysM domain
I8N73_RS07195	COG3858	chitin binding
I8N73_RS07205	COG4873	Protein conserved in bacteria
I8N73_RS07215	COG3773	Cell wall hydrolase
I8N73_RS07220	COG2244	polysaccharide biosynthetic process
I8N73_RS07225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS07230	COG2217	Heavy metal translocating P-type atpase
I8N73_RS07235	COG0006	proline dipeptidase activity
I8N73_RS07240	COG1609	Transcriptional regulator
I8N73_RS07245	COG3711	transcriptional antiterminator
I8N73_RS07250	COG2190	(PTS) system
I8N73_RS07250	COG1263	PTS System
I8N73_RS07250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS07255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS07260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8N73_RS07270	COG1533	DNA photolyase activity
I8N73_RS07275	COG0840	transmembrane signaling receptor activity
I8N73_RS07280	COG2084	Dehydrogenase
I8N73_RS07285	COG2340	Cysteine-rich secretory protein family
I8N73_RS07290	COG0768	penicillin binding
I8N73_RS07295	COG4191	Histidine kinase
I8N73_RS07300	COG0436	Aminotransferase
I8N73_RS07310	COG0784	Response regulator, receiver
I8N73_RS07310	COG0835	chemotaxis
I8N73_RS07320	COG2814	Major facilitator Superfamily
I8N73_RS07325	COG1376	ErfK ybiS ycfS ynhG family protein
I8N73_RS07330	COG1408	metallophosphoesterase
I8N73_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS07345	COG2200	EAL domain
I8N73_RS07350	COG4703	Protein of unknown function (DUF1797)
I8N73_RS07355	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I8N73_RS07365	COG0517	IMP dehydrogenase activity
I8N73_RS07370	COG0583	DNA-binding transcription factor activity
I8N73_RS07375	COG0716	FMN binding
I8N73_RS07385	COG0716	FMN binding
I8N73_RS07405	COG0668	transmembrane transport
I8N73_RS07410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS07430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_RS07435	COG0303	'Molybdopterin
I8N73_RS07440	COG1763	Mo-molybdopterin cofactor biosynthetic process
I8N73_RS07445	COG0314	molybdopterin synthase activity
I8N73_RS07450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I8N73_RS07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8N73_RS07465	COG1136	(ABC) transporter
I8N73_RS07470	COG0577	efflux transmembrane transporter activity
I8N73_RS07475	COG1349	DNA-binding transcription factor activity
I8N73_RS07480	COG1105	Belongs to the carbohydrate kinase PfkB family
I8N73_RS07485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_RS07485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_RS07485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS07490	COG0681	Belongs to the peptidase S26 family
I8N73_RS07500	COG0488	(ABC) transporter
I8N73_RS07505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N73_RS07510	COG2309	aminopeptidase activity
I8N73_RS07520	COG1077	Cell shape determining protein MreB Mrl
I8N73_RS07525	COG2002	toxin-antitoxin pair type II binding
I8N73_RS07530	COG3852	Histidine kinase
I8N73_RS07535	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I8N73_RS07535	COG2105	PFAM AIG2 family protein
I8N73_RS07540	COG0569	domain protein
I8N73_RS07550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N73_RS07560	COG0561	phosphatase activity
I8N73_RS07565	COG0242	peptide deformylase activity
I8N73_RS07575	COG0497	DNA recombination
I8N73_RS07585	COG3321	synthase
I8N73_RS07585	COG4221	oxidoreductase activity
I8N73_RS07585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS07590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS07590	COG0300	oxidoreductase activity
I8N73_RS07590	COG3321	synthase
I8N73_RS07590	COG4221	oxidoreductase activity
I8N73_RS07595	COG4221	oxidoreductase activity
I8N73_RS07595	COG3321	synthase
I8N73_RS07595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS07600	COG0300	oxidoreductase activity
I8N73_RS07600	COG4221	oxidoreductase activity
I8N73_RS07600	COG3321	synthase
I8N73_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS07605	COG4221	oxidoreductase activity
I8N73_RS07605	COG3321	synthase
I8N73_RS07605	COG0300	oxidoreductase activity
I8N73_RS07605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS07610	COG4221	oxidoreductase activity
I8N73_RS07610	COG3321	synthase
I8N73_RS07610	COG0300	oxidoreductase activity
I8N73_RS07610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS07615	COG4221	oxidoreductase activity
I8N73_RS07615	COG3321	synthase
I8N73_RS07615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS07620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_RS07625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_RS07630	COG0022	dehydrogenase e1 component
I8N73_RS07635	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_RS07645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS07660	COG1982	Orn Lys Arg decarboxylase major
I8N73_RS07680	COG0483	inositol monophosphate 1-phosphatase activity
I8N73_RS07690	COG3227	Zinc metalloprotease (Elastase)
I8N73_RS07715	COG1217	gtp-binding protein TYPA
I8N73_RS07725	COG4896	Protein conserved in bacteria
I8N73_RS07735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8N73_RS07740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N73_RS07745	COG2066	Belongs to the glutaminase family
I8N73_RS07755	COG0772	Belongs to the SEDS family
I8N73_RS07760	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I8N73_RS07775	COG2010	Cytochrome c
I8N73_RS07775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N73_RS07780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N73_RS07785	COG1845	cytochrome c oxidase, subunit III
I8N73_RS07790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8N73_RS07795	COG3336	cytochrome c oxidase
I8N73_RS07805	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I8N73_RS07810	COG2340	Cysteine-rich secretory protein family
I8N73_RS07825	COG3679	Belongs to the UPF0342 family
I8N73_RS07840	COG0742	ribosomal rna small subunit methyltransferase
I8N73_RS07850	COG3314	Sporulation integral membrane protein YlbJ
I8N73_RS07855	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N73_RS07860	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8N73_RS07870	COG1399	metal-binding, possibly nucleic acid-binding protein
I8N73_RS07890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N73_RS07910	COG4839	cell division protein FtsL
I8N73_RS07915	COG0768	penicillin binding
I8N73_RS07920	COG0768	penicillin binding
I8N73_RS07940	COG0772	Belongs to the SEDS family
I8N73_RS07955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8N73_RS07960	COG0849	cell division
I8N73_RS07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8N73_RS07970	COG1404	Belongs to the peptidase S8 family
I8N73_RS07970	COG4412	M6 family metalloprotease domain protein
I8N73_RS07980	COG1191	sigma factor activity
I8N73_RS07985	COG1191	sigma factor activity
I8N73_RS07990	COG1119	ATPase activity
I8N73_RS07995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_RS08000	COG1873	PFAM PRC-barrel domain
I8N73_RS08005	COG1496	oxidoreductase activity
I8N73_RS08010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I8N73_RS08020	COG0762	integral membrane protein
I8N73_RS08025	COG2302	S4 RNA-binding domain
I8N73_RS08030	COG3599	regulation of cell shape
I8N73_RS08035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8N73_RS08040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_RS08050	COG0564	pseudouridine synthase activity
I8N73_RS08060	COG2233	PERMEase
I8N73_RS08070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8N73_RS08075	COG0505	Belongs to the CarA family
I8N73_RS08080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N73_RS08095	COG0284	orotidine-5'-phosphate decarboxylase activity
I8N73_RS08100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8N73_RS08110	COG0306	phosphate transporter
I8N73_RS08125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N73_RS08130	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I8N73_RS08135	COG1648	precorrin-2 dehydrogenase activity
I8N73_RS08145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8N73_RS08150	COG1561	YicC-like family, N-terminal region
I8N73_RS08160	COG0194	GDP metabolic process
I8N73_RS08170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N73_RS08175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N73_RS08180	COG0242	peptide deformylase activity
I8N73_RS08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8N73_RS08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I8N73_RS08200	COG0631	protein serine/threonine phosphatase activity
I8N73_RS08205	COG0515	serine threonine protein kinase
I8N73_RS08205	COG2815	serine threonine protein kinase
I8N73_RS08215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8N73_RS08220	COG1564	THIamine pyrophosphokinase
I8N73_RS08235	COG1302	Protein conserved in bacteria
I8N73_RS08240	COG1461	Dihydroxyacetone kinase
I8N73_RS08245	COG1760	l-serine dehydratase
I8N73_RS08250	COG1760	l-serine dehydratase
I8N73_RS08255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I8N73_RS08270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N73_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS08290	COG1196	nuclear chromosome segregation
I8N73_RS08295	COG0552	protein localization to endoplasmic reticulum
I8N73_RS08310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I8N73_RS08320	COG1837	Belongs to the UPF0109 family
I8N73_RS08345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N73_RS08360	COG2257	FlhB HrpN YscU SpaS Family
I8N73_RS08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I8N73_RS08375	COG0758	DNA mediated transformation
I8N73_RS08380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N73_RS08390	COG4974	Belongs to the 'phage' integrase family
I8N73_RS08410	COG1815	bacterial-type flagellum-dependent cell motility
I8N73_RS08415	COG1558	bacterial-type flagellum-dependent cell motility
I8N73_RS08420	COG1677	Flagellar hook-basal body complex protein FliE
I8N73_RS08425	COG1766	The M ring may be actively involved in energy transduction
I8N73_RS08430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_RS08435	COG1317	bacterial-type flagellum organization
I8N73_RS08440	COG1157	protein secretion by the type III secretion system
I8N73_RS08445	COG2882	bacterial-type flagellum organization
I8N73_RS08450	COG3334	PFAM MgtE intracellular
I8N73_RS08455	COG3144	bacterial-type flagellum assembly
I8N73_RS08460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I8N73_RS08465	COG4786	Flagellar basal body rod
I8N73_RS08470	COG1582	Flagellar protein (FlbD)
I8N73_RS08475	COG1580	Controls the rotational direction of flagella during chemotaxis
I8N73_RS08480	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_RS08485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_RS08485	COG1776	CheC inhibitor of MCP methylation
I8N73_RS08490	COG2201	protein-glutamate methylesterase activity
I8N73_RS08495	COG3190	flagellar
I8N73_RS08500	COG1338	Plays a role in the flagellum-specific transport system
I8N73_RS08505	COG1987	bacterial-type flagellum assembly
I8N73_RS08510	COG1684	flagellar biosynthetic protein fliR
I8N73_RS08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N73_RS08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N73_RS08525	COG1419	protein localization to endoplasmic reticulum
I8N73_RS08530	COG0455	bacterial-type flagellum organization
I8N73_RS08535	COG2201	protein-glutamate methylesterase activity
I8N73_RS08540	COG0643	Histidine kinase
I8N73_RS08540	COG2198	Histidine kinase
I8N73_RS08545	COG0835	chemotaxis
I8N73_RS08550	COG1776	CheC inhibitor of MCP methylation
I8N73_RS08560	COG1191	sigma factor activity
I8N73_RS08590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8N73_RS08595	COG4589	Belongs to the CDS family
I8N73_RS08605	COG0750	zinc metalloprotease
I8N73_RS08615	COG2176	DNA-directed DNA polymerase activity
I8N73_RS08625	COG0195	Participates in both transcription termination and antitermination
I8N73_RS08630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I8N73_RS08635	COG1358	cellular component organization or biogenesis
I8N73_RS08645	COG1550	Protein conserved in bacteria
I8N73_RS08660	COG0196	riboflavin kinase activity
I8N73_RS08675	COG0726	polysaccharide deacetylase
I8N73_RS08680	COG0612	Peptidase, M16
I8N73_RS08685	COG1873	PFAM PRC-barrel domain
I8N73_RS08690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N73_RS08695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N73_RS08700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I8N73_RS08705	COG0527	aspartate kinase activity
I8N73_RS08715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N73_RS08720	COG0740	serine-type endopeptidase activity
I8N73_RS08730	COG1674	ftsk spoiiie
I8N73_RS08730	COG4980	gas vesicle protein
I8N73_RS08735	COG2188	Transcriptional regulator
I8N73_RS08740	COG2814	Major facilitator Superfamily
I8N73_RS08745	COG1846	Transcriptional regulator
I8N73_RS08750	COG2409	Drug exporters of the RND superfamily
I8N73_RS08750	COG1033	growth of symbiont in host cell
I8N73_RS08755	COG0612	Peptidase, M16
I8N73_RS08760	COG0612	Peptidase, M16
I8N73_RS08765	COG0300	oxidoreductase activity
I8N73_RS08780	COG1426	Protein conserved in bacteria
I8N73_RS08785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8N73_RS08800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_RS08810	COG1692	metallophosphoesterase
I8N73_RS08815	COG2359	stage V sporulation protein S
I8N73_RS08835	COG4550	Control of competence regulator ComK, YlbF/YmcA
I8N73_RS08900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS08905	COG3425	synthase
I8N73_RS08910	COG1024	Enoyl-CoA hydratase
I8N73_RS08915	COG1024	Enoyl-CoA hydratase
I8N73_RS08920	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS08920	COG0300	oxidoreductase activity
I8N73_RS08920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS08920	COG3321	synthase
I8N73_RS08925	COG4221	oxidoreductase activity
I8N73_RS08925	COG3321	synthase
I8N73_RS08925	COG0300	oxidoreductase activity
I8N73_RS08925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS08930	COG3321	synthase
I8N73_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS08930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS08930	COG3321	synthase
I8N73_RS08930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS08930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS08930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS08935	COG4221	oxidoreductase activity
I8N73_RS08935	COG3321	synthase
I8N73_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS08935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS08940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8N73_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS08940	COG3321	synthase
I8N73_RS08940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N73_RS08945	COG2124	cytochrome p450
I8N73_RS08950	COG3209	COG3209 Rhs family protein
I8N73_RS08955	COG3619	membrane
I8N73_RS08980	COG4195	phage-related replication protein
I8N73_RS08985	COG1764	response to oxidative stress
I8N73_RS08995	COG2076	Multidrug Resistance protein
I8N73_RS09035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_RS09040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_RS09045	COG4112	unkown
I8N73_RS09050	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS09060	COG1525	nuclease
I8N73_RS09065	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_RS09075	COG5444	nuclease activity
I8N73_RS09120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N73_RS09125	COG0457	Tetratricopeptide repeat
I8N73_RS09145	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS09145	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS09150	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_RS09170	COG2433	Pfam Transposase IS66
I8N73_RS09180	COG1196	nuclear chromosome segregation
I8N73_RS09180	COG0741	lytic transglycosylase activity
I8N73_RS09180	COG0739	heme binding
I8N73_RS09195	COG0582	viral genome integration into host DNA
I8N73_RS09295	COG4373	Mu-like prophage FluMu protein gp28
I8N73_RS09340	COG0776	regulation of translation
I8N73_RS09420	COG3655	Transcriptional regulator
I8N73_RS09540	COG3655	Transcriptional regulator
I8N73_RS09615	COG3645	SOS response
I8N73_RS09615	COG3646	Phage regulatory protein
I8N73_RS09625	COG1793	dna ligase
I8N73_RS09630	COG2135	peptidase activity
I8N73_RS09650	COG4195	phage-related replication protein
I8N73_RS09655	COG3420	alginic acid biosynthetic process
I8N73_RS09655	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_RS09705	COG3584	3D domain protein
I8N73_RS09720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8N73_RS09725	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I8N73_RS09800	COG1780	Probably involved in ribonucleotide reductase function
I8N73_RS09805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_RS09805	COG1372	Participates in initiation and elongation during chromosome replication
I8N73_RS09815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_RS09820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS09830	COG0756	dUTP diphosphatase activity
I8N73_RS09850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I8N73_RS09855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_RS09890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N73_RS09925	COG3331	DNA recombination
I8N73_RS09940	COG0464	growth
I8N73_RS09945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8N73_RS09950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I8N73_RS09955	COG0789	Transcriptional regulator
I8N73_RS09960	COG0174	glutamine synthetase
I8N73_RS09970	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_RS09995	COG2211	Major facilitator Superfamily
I8N73_RS10000	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_RS10015	COG1070	Carbohydrate kinase
I8N73_RS10020	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_RS10020	COG3848	Pyruvate phosphate dikinase
I8N73_RS10040	COG1064	alcohol dehydrogenase
I8N73_RS10060	COG0456	acetyltransferase
I8N73_RS10085	COG3397	chitin binding
I8N73_RS10095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS10110	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_RS10115	COG0756	dUTP diphosphatase activity
I8N73_RS10120	COG4195	phage-related replication protein
I8N73_RS10155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N73_RS10165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I8N73_RS10185	COG0785	Cytochrome C biogenesis protein
I8N73_RS10190	COG2201	protein-glutamate methylesterase activity
I8N73_RS10195	COG4846	Membrane protein involved in cytochrome C biogenesis
I8N73_RS10205	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_RS10220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8N73_RS10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS10245	COG0824	Thioesterase
I8N73_RS10255	COG4841	protein insertion into membrane
I8N73_RS10265	COG1832	CoA-binding protein
I8N73_RS10270	COG0187	DNA topoisomerase II activity
I8N73_RS10275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N73_RS10285	COG1115	amino acid carrier protein
I8N73_RS10295	COG1063	alcohol dehydrogenase
I8N73_RS10300	COG0800	Aldolase
I8N73_RS10305	COG1312	Catalyzes the dehydration of D-mannonate
I8N73_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS10315	COG1609	Transcriptional regulator
I8N73_RS10320	COG2271	Major facilitator Superfamily
I8N73_RS10360	COG0457	Tetratricopeptide repeat
I8N73_RS10390	COG0577	efflux transmembrane transporter activity
I8N73_RS10390	COG1136	(ABC) transporter
I8N73_RS10420	COG2205	protein histidine kinase activity
I8N73_RS10425	COG0745	RESPONSE REGULATOR receiver
I8N73_RS10435	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS10465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N73_RS10470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N73_RS10475	COG2610	gluconate transmembrane transporter activity
I8N73_RS10480	COG2124	cytochrome p450
I8N73_RS10500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_RS10510	COG2246	polysaccharide biosynthetic process
I8N73_RS10515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N73_RS10520	COG0586	Pfam SNARE associated Golgi protein
I8N73_RS10525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N73_RS10530	COG1024	Enoyl-CoA hydratase
I8N73_RS10535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8N73_RS10540	COG0511	ligase activity, forming carbon-carbon bonds
I8N73_RS10545	COG0439	Biotin carboxylase
I8N73_RS10550	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS10555	COG1960	acyl-CoA dehydrogenase activity
I8N73_RS10560	COG1649	PFAM Uncharacterised BCR, COG1649
I8N73_RS10570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS10570	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N73_RS10575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS10580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS10585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS10590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS10595	COG2027	D-alanyl-D-alanine carboxypeptidase
I8N73_RS10600	COG2017	converts alpha-aldose to the beta-anomer
I8N73_RS10605	COG0534	Mate efflux family protein
I8N73_RS10620	COG0582	viral genome integration into host DNA
I8N73_RS10625	COG0166	Belongs to the GPI family
I8N73_RS10630	COG0405	Gamma-glutamyltransferase
I8N73_RS10635	COG2814	Major facilitator Superfamily
I8N73_RS10640	COG0640	Transcriptional regulator
I8N73_RS10645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8N73_RS10655	COG0604	alcohol dehydrogenase
I8N73_RS10660	COG0493	'glutamate synthase
I8N73_RS10665	COG0069	glutamate synthase activity
I8N73_RS10665	COG0070	glutamate synthase
I8N73_RS10665	COG0067	glutamate synthase
I8N73_RS10670	COG0583	DNA-binding transcription factor activity
I8N73_RS10675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N73_RS10690	COG0300	oxidoreductase activity
I8N73_RS10695	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N73_RS10705	COG2814	Major facilitator Superfamily
I8N73_RS10710	COG1070	Carbohydrate kinase
I8N73_RS10715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N73_RS10720	COG0243	molybdopterin cofactor binding
I8N73_RS10745	COG5444	nuclease activity
I8N73_RS10750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_RS10760	COG1309	transcriptional regulator
I8N73_RS10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS10775	COG0640	Transcriptional regulator
I8N73_RS10780	COG0741	lytic transglycosylase activity
I8N73_RS10785	COG2322	membrane
I8N73_RS10800	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N73_RS10810	COG3584	3D domain protein
I8N73_RS10810	COG1388	LysM domain
I8N73_RS10815	COG0514	ATP-dependent DNA helicase (RecQ)
I8N73_RS10825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8N73_RS10830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_RS10845	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_RS10875	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS10880	COG1657	PFAM Prenyltransferase squalene oxidase
I8N73_RS10885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N73_RS10890	COG0733	neurotransmitter:sodium symporter activity
I8N73_RS10895	COG0385	Bile acid
I8N73_RS10900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS10905	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_RS10915	COG4548	von Willebrand factor, type A
I8N73_RS10920	COG0714	Associated with various cellular activities
I8N73_RS10925	COG2032	superoxide dismutase activity
I8N73_RS10930	COG1388	LysM domain
I8N73_RS10930	COG0791	NLP P60 protein
I8N73_RS10935	COG1819	glycosyl
I8N73_RS10940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N73_RS10945	COG0534	Mate efflux family protein
I8N73_RS10950	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_RS10960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_RS10970	COG2962	Rard protein
I8N73_RS10985	COG1942	4-Oxalocrotonate Tautomerase
I8N73_RS10995	COG1733	regulation of RNA biosynthetic process
I8N73_RS11000	COG0778	Nitroreductase
I8N73_RS11005	COG0400	carboxylic ester hydrolase activity
I8N73_RS11010	COG0346	lactoylglutathione lyase activity
I8N73_RS11020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_RS11030	COG2723	6-phospho-beta-galactosidase activity
I8N73_RS11035	COG2188	Transcriptional regulator
I8N73_RS11040	COG0793	Belongs to the peptidase S41A family
I8N73_RS11040	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS11045	COG2226	methyltransferase
I8N73_RS11055	COG1876	peptidase activity
I8N73_RS11075	COG0671	phosphoesterase, PA-phosphatase related
I8N73_RS11105	COG1509	lysine 2,3-aminomutase activity
I8N73_RS11110	COG0456	acetyltransferase
I8N73_RS11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_RS11120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N73_RS11125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N73_RS11130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_RS11135	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I8N73_RS11145	COG0456	acetyltransferase
I8N73_RS11150	COG0463	Glycosyl transferase, family 2
I8N73_RS11165	COG4641	Protein conserved in bacteria
I8N73_RS11175	COG1086	Polysaccharide biosynthesis protein
I8N73_RS11220	COG1388	LysM domain
I8N73_RS11225	COG0457	Tetratricopeptide repeat
I8N73_RS11235	COG3391	amine dehydrogenase activity
I8N73_RS11250	COG5444	nuclease activity
I8N73_RS11255	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_RS11260	COG1525	nuclease
I8N73_RS11265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N73_RS11285	COG1846	Transcriptional regulator
I8N73_RS11290	COG4698	Protein conserved in bacteria
I8N73_RS11295	COG2755	lipolytic protein G-D-S-L family
I8N73_RS11300	COG1999	signal sequence binding
I8N73_RS11310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8N73_RS11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I8N73_RS11320	COG1272	protein, Hemolysin III
I8N73_RS11325	COG0204	Acyl-transferase
I8N73_RS11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_RS11345	COG2136	Putative SAM-dependent methyltransferase
I8N73_RS11345	COG2521	methyltransferase
I8N73_RS11360	COG1413	lyase activity
I8N73_RS11370	COG0386	Belongs to the glutathione peroxidase family
I8N73_RS11380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N73_RS11390	COG1278	Cold shock
I8N73_RS11410	COG0328	RNA-DNA hybrid ribonuclease activity
I8N73_RS11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I8N73_RS11420	COG0328	RNA-DNA hybrid ribonuclease activity
I8N73_RS11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_RS11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N73_RS11455	COG1755	Isoprenylcysteine carboxyl methyltransferase
I8N73_RS11460	COG3424	synthase
I8N73_RS11485	COG1335	isochorismatase
I8N73_RS11495	COG2233	PERMEase
I8N73_RS11505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I8N73_RS11510	COG1199	ATP-dependent helicase activity
I8N73_RS11525	COG0116	Belongs to the methyltransferase superfamily
I8N73_RS11555	COG3359	exonuclease
I8N73_RS11560	COG1205	dead DEAH box helicase
I8N73_RS11560	COG1111	helicase
I8N73_RS11565	COG2190	(PTS) system
I8N73_RS11570	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_RS11610	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N73_RS11610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_RS11620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I8N73_RS11625	COG3935	DnaD domain protein
I8N73_RS11635	COG0436	Aminotransferase
I8N73_RS11640	COG5353	protein conserved in bacteria
I8N73_RS11650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8N73_RS11650	COG1199	ATP-dependent helicase activity
I8N73_RS11680	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_RS11700	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N73_RS11705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS11710	COG2140	Oxalate decarboxylase
I8N73_RS11720	COG4347	Protein of unknown function (DUF1405)
I8N73_RS11725	COG2010	Cytochrome c
I8N73_RS11725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N73_RS11730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N73_RS11735	COG0723	plastoquinol--plastocyanin reductase activity
I8N73_RS11750	COG0457	Tetratricopeptide repeat
I8N73_RS11765	COG0287	Prephenate dehydrogenase
I8N73_RS11800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N73_RS11805	COG4401	Chorismate mutase type I
I8N73_RS11820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I8N73_RS11825	COG0105	UTP biosynthetic process
I8N73_RS11830	COG0142	geranyltranstransferase activity
I8N73_RS11840	COG0142	geranyltranstransferase activity
I8N73_RS11855	COG0776	regulation of translation
I8N73_RS11860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N73_RS11900	COG0539	negative regulation of cytoplasmic translation
I8N73_RS11915	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I8N73_RS11920	COG2959	enzyme of heme biosynthesis
I8N73_RS11925	COG3773	Cell wall hydrolase
I8N73_RS11925	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS11930	COG2339	peptidase activity
I8N73_RS11935	COG0492	ferredoxin-NADP+ reductase activity
I8N73_RS11940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_RS11945	COG4862	establishment of competence for transformation
I8N73_RS11950	COG1408	metallophosphoesterase
I8N73_RS11960	COG1388	LysM domain
I8N73_RS11965	COG1266	CAAX protease self-immunity
I8N73_RS11970	COG0514	ATP-dependent DNA helicase (RecQ)
I8N73_RS11975	COG4955	Helix-turn-helix domain
I8N73_RS11980	COG1141	Ferredoxin
I8N73_RS11985	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I8N73_RS11990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N73_RS12000	COG1595	DNA-templated transcription, initiation
I8N73_RS12005	COG5002	protein histidine kinase activity
I8N73_RS12010	COG0745	RESPONSE REGULATOR receiver
I8N73_RS12015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N73_RS12020	COG1333	cytochrome c biogenesis protein
I8N73_RS12025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS12030	COG1187	pseudouridine synthase activity
I8N73_RS12035	COG0700	Nucleoside recognition
I8N73_RS12040	COG2715	membrane protein required for spore maturation
I8N73_RS12045	COG1686	Belongs to the peptidase S11 family
I8N73_RS12070	COG1547	Domain of unknown function (DUF309)
I8N73_RS12075	COG0456	acetyltransferase
I8N73_RS12090	COG0307	riboflavin synthase, alpha
I8N73_RS12095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N73_RS12095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N73_RS12105	COG0681	Belongs to the peptidase S26 family
I8N73_RS12115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I8N73_RS12120	COG4086	secreted protein
I8N73_RS12125	COG0019	diaminopimelate decarboxylase activity
I8N73_RS12130	COG0697	spore germination
I8N73_RS12145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_RS12165	COG1191	sigma factor activity
I8N73_RS12175	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS12180	COG1686	Belongs to the peptidase S11 family
I8N73_RS12185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8N73_RS12190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I8N73_RS12195	COG4974	Belongs to the 'phage' integrase family
I8N73_RS12205	COG0735	belongs to the Fur family
I8N73_RS12210	COG1300	Membrane
I8N73_RS12225	COG0281	malic enzyme
I8N73_RS12230	COG1757	Na H antiporter
I8N73_RS12235	COG1027	Aspartate ammonia-lyase
I8N73_RS12240	COG0252	asparaginase activity
I8N73_RS12245	COG1396	sequence-specific DNA binding
I8N73_RS12250	COG1379	DNA repair
I8N73_RS12255	COG0494	nUDIX hydrolase
I8N73_RS12265	COG0667	Aldo Keto reductase
I8N73_RS12275	COG1073	alpha beta
I8N73_RS12285	COG4918	Iron-sulphur cluster biosynthesis
I8N73_RS12290	COG0456	acetyltransferase
I8N73_RS12290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8N73_RS12295	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_RS12300	COG0456	acetyltransferase
I8N73_RS12305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N73_RS12330	COG0346	lactoylglutathione lyase activity
I8N73_RS12340	COG3048	D-serine ammonia-lyase activity
I8N73_RS12345	COG0300	oxidoreductase activity
I8N73_RS12350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS12355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N73_RS12360	COG1024	Enoyl-CoA hydratase
I8N73_RS12365	COG3425	synthase
I8N73_RS12370	COG2124	cytochrome p450
I8N73_RS12375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS12375	COG3321	synthase
I8N73_RS12380	COG3321	synthase
I8N73_RS12380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS12380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12385	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS12385	COG0300	oxidoreductase activity
I8N73_RS12385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12385	COG3321	synthase
I8N73_RS12390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12390	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12390	COG3321	synthase
I8N73_RS12390	COG0300	oxidoreductase activity
I8N73_RS12395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS12395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS12395	COG3321	synthase
I8N73_RS12400	COG0300	oxidoreductase activity
I8N73_RS12400	COG3321	synthase
I8N73_RS12400	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS12400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS12405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS12405	COG3321	synthase
I8N73_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS12430	COG2070	2-Nitropropane dioxygenase
I8N73_RS12430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N73_RS12435	COG0250	Participates in transcription elongation, termination and antitermination
I8N73_RS12455	COG0596	Alpha beta hydrolase
I8N73_RS12470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8N73_RS12475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8N73_RS12490	COG0706	membrane insertase activity
I8N73_RS12495	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8N73_RS12500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N73_RS12505	COG0346	lactoylglutathione lyase activity
I8N73_RS12515	COG1376	ErfK ybiS ycfS ynhG family protein
I8N73_RS12520	COG4129	membrane
I8N73_RS12525	COG1126	abc transporter atp-binding protein
I8N73_RS12530	COG0765	amino acid transport
I8N73_RS12535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS12545	COG1597	lipid kinase activity
I8N73_RS12550	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_RS12555	COG0022	dehydrogenase e1 component
I8N73_RS12560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_RS12565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_RS12570	COG3426	butyrate kinase activity
I8N73_RS12575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_RS12580	COG0280	phosphate acetyltransferase
I8N73_RS12585	COG3290	protein histidine kinase activity
I8N73_RS12585	COG3829	transcription factor binding
I8N73_RS12595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I8N73_RS12600	COG2079	MmgE PrpD family protein
I8N73_RS12605	COG0372	Belongs to the citrate synthase family
I8N73_RS12610	COG1960	acyl-CoA dehydrogenase activity
I8N73_RS12615	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N73_RS12620	COG0183	Belongs to the thiolase family
I8N73_RS12625	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_RS12630	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS12655	COG1902	pentaerythritol trinitrate reductase activity
I8N73_RS12670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N73_RS12675	COG0745	RESPONSE REGULATOR receiver
I8N73_RS12680	COG0750	zinc metalloprotease
I8N73_RS12685	COG0497	DNA recombination
I8N73_RS12695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I8N73_RS12705	COG0142	geranyltranstransferase activity
I8N73_RS12715	COG1570	exodeoxyribonuclease VII activity
I8N73_RS12730	COG1302	Protein conserved in bacteria
I8N73_RS12735	COG0439	Biotin carboxylase
I8N73_RS12740	COG0511	ligase activity, forming carbon-carbon bonds
I8N73_RS12780	COG3854	ATPases associated with a variety of cellular activities
I8N73_RS12795	COG0006	proline dipeptidase activity
I8N73_RS12805	COG3872	metal-dependent enzyme
I8N73_RS12815	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N73_RS12830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N73_RS12850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N73_RS12865	COG1396	sequence-specific DNA binding
I8N73_RS12875	COG0681	Belongs to the peptidase S26 family
I8N73_RS12900	COG4940	Competence protein ComGF
I8N73_RS12910	COG4970	Tfp pilus assembly protein FimT
I8N73_RS12915	COG4537	Required for transformation and DNA binding
I8N73_RS12920	COG1459	type II secretion system
I8N73_RS12925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8N73_RS12930	COG0598	Magnesium transport protein CorA
I8N73_RS12935	COG1253	flavin adenine dinucleotide binding
I8N73_RS12940	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS12950	COG1393	Belongs to the ArsC family
I8N73_RS12960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS12970	COG0011	TIGRFAM Protein of
I8N73_RS12980	COG2866	Carboxypeptidase
I8N73_RS12985	COG1940	carbohydrate kinase activity
I8N73_RS12990	COG4483	Protein conserved in bacteria
I8N73_RS12995	COG1757	Na H antiporter
I8N73_RS13005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8N73_RS13020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N73_RS13025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_RS13030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_RS13035	COG0581	inorganic phosphate transmembrane transporter activity
I8N73_RS13040	COG0573	inorganic phosphate transmembrane transporter activity
I8N73_RS13045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8N73_RS13050	COG0768	penicillin binding
I8N73_RS13055	COG0477	Major facilitator Superfamily
I8N73_RS13060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N73_RS13065	COG2839	Protein conserved in bacteria
I8N73_RS13070	COG5521	maltodextrose utilization protein MalA
I8N73_RS13075	COG1388	LysM domain
I8N73_RS13085	COG4709	membrane
I8N73_RS13090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I8N73_RS13095	COG0735	belongs to the Fur family
I8N73_RS13100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS13115	COG0513	Belongs to the DEAD box helicase family
I8N73_RS13130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8N73_RS13135	COG2384	SAM-dependent methyltransferase
I8N73_RS13140	COG2010	Cytochrome c
I8N73_RS13145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8N73_RS13150	COG0358	DNA primase activity
I8N73_RS13165	COG0517	IMP dehydrogenase activity
I8N73_RS13170	COG0751	glycine-tRNA ligase activity
I8N73_RS13190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8N73_RS13195	COG0295	cytidine deaminase activity
I8N73_RS13200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I8N73_RS13210	COG1480	7TM receptor with intracellular HD hydrolase
I8N73_RS13215	COG1702	phosphate starvation-inducible protein PhoH
I8N73_RS13220	COG0561	phosphatase activity
I8N73_RS13235	COG4864	UPF0365 protein
I8N73_RS13240	COG1030	water channel activity
I8N73_RS13245	COG1610	YqeY-like protein
I8N73_RS13255	COG1283	sodium-dependent phosphate transmembrane transporter activity
I8N73_RS13260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8N73_RS13265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8N73_RS13295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N73_RS13310	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS13325	COG1466	dna polymerase III delta subunit
I8N73_RS13340	COG2333	competence protein COMEC
I8N73_RS13340	COG0658	competence protein
I8N73_RS13345	COG2131	deaminase
I8N73_RS13350	COG1555	photosystem II stabilization
I8N73_RS13350	COG1596	polysaccharide export
I8N73_RS13355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N73_RS13360	COG2226	methyltransferase
I8N73_RS13365	COG0799	negative regulation of ribosome biogenesis
I8N73_RS13370	COG1713	HD superfamily hydrolase involved in NAD metabolism
I8N73_RS13380	COG1534	Rna-binding protein
I8N73_RS13385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8N73_RS13390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N73_RS13395	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I8N73_RS13405	COG2755	lipolytic protein G-D-S-L family
I8N73_RS13415	COG0398	Pfam SNARE associated Golgi protein
I8N73_RS13450	COG5444	nuclease activity
I8N73_RS13455	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_RS13470	COG0583	DNA-binding transcription factor activity
I8N73_RS13485	COG5002	protein histidine kinase activity
I8N73_RS13485	COG0642	Histidine kinase
I8N73_RS13490	COG0745	RESPONSE REGULATOR receiver
I8N73_RS13495	COG2311	Membrane
I8N73_RS13505	COG0454	-acetyltransferase
I8N73_RS13510	COG0563	adenylate kinase activity
I8N73_RS13520	COG2814	Major facilitator Superfamily
I8N73_RS13530	COG0456	acetyltransferase
I8N73_RS13535	COG2318	DinB family
I8N73_RS13545	COG0561	phosphatase activity
I8N73_RS13550	COG0561	phosphatase activity
I8N73_RS13560	COG1482	cell wall glycoprotein biosynthetic process
I8N73_RS13565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_RS13565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_RS13565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS13570	COG3711	transcriptional antiterminator
I8N73_RS13570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS13580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8N73_RS13585	COG0583	DNA-binding transcription factor activity
I8N73_RS13590	COG2814	Major facilitator Superfamily
I8N73_RS13595	COG2124	cytochrome p450
I8N73_RS13595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_RS13600	COG1309	transcriptional regulator
I8N73_RS13605	COG2226	methyltransferase
I8N73_RS13620	COG2116	formate transmembrane transporter activity
I8N73_RS13625	COG5609	conserved protein (DUF2294)
I8N73_RS13630	COG3383	formate dehydrogenase (NAD+) activity
I8N73_RS13635	COG2427	Protein of unknown function (DUF1641)
I8N73_RS13645	COG0626	cystathionine gamma-synthase activity
I8N73_RS13650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_RS13675	COG0768	penicillin binding
I8N73_RS13690	COG0826	peptidase U32
I8N73_RS13695	COG0826	peptidase U32
I8N73_RS13700	COG4122	O-methyltransferase activity
I8N73_RS13705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N73_RS13720	COG4472	Bacterial protein of unknown function (DUF965)
I8N73_RS13730	COG0628	permease
I8N73_RS13735	COG1126	abc transporter atp-binding protein
I8N73_RS13740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS13745	COG0765	amino acid transport
I8N73_RS13750	COG0765	amino acid transport
I8N73_RS13765	COG3881	PFAM PRC-barrel domain
I8N73_RS13770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8N73_RS13775	COG0457	Tetratricopeptide repeat
I8N73_RS13785	COG1104	cysteine desulfurase activity
I8N73_RS13790	COG1959	2 iron, 2 sulfur cluster binding
I8N73_RS13795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8N73_RS13800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I8N73_RS13825	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS13825	COG4991	sh3 domain protein
I8N73_RS13825	COG3103	Sh3 type 3 domain protein
I8N73_RS13835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8N73_RS13845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I8N73_RS13845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8N73_RS13850	COG5416	Lipopolysaccharide assembly protein A domain
I8N73_RS13855	COG0490	domain, Protein
I8N73_RS13860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N73_RS13860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N73_RS13870	COG2244	polysaccharide biosynthetic process
I8N73_RS13875	COG2323	membrane
I8N73_RS13885	COG1862	Preprotein translocase
I8N73_RS13930	COG1388	LysM domain
I8N73_RS13940	COG0157	Belongs to the NadC ModD family
I8N73_RS13945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8N73_RS13950	COG1104	cysteine desulfurase activity
I8N73_RS13955	COG1827	regulation of RNA biosynthetic process
I8N73_RS13960	COG0077	Prephenate dehydratase
I8N73_RS13975	COG3290	protein histidine kinase activity
I8N73_RS13980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8N73_RS13985	COG2868	ribosomal protein
I8N73_RS13995	COG1994	Peptidase M50
I8N73_RS14000	COG0739	heme binding
I8N73_RS14005	COG2894	cell division
I8N73_RS14015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I8N73_RS14025	COG1077	Cell shape determining protein MreB Mrl
I8N73_RS14045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I8N73_RS14050	COG0285	dihydrofolate synthase activity
I8N73_RS14055	COG0525	valine-tRNA ligase activity
I8N73_RS14065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_RS14070	COG1388	LysM domain
I8N73_RS14080	COG0113	porphobilinogen synthase activity
I8N73_RS14085	COG1587	Uroporphyrinogen-III synthase
I8N73_RS14095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N73_RS14115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8N73_RS14120	COG0470	DNA polymerase III
I8N73_RS14120	COG1067	ATP-dependent peptidase activity
I8N73_RS14135	COG0457	Tetratricopeptide repeat
I8N73_RS14135	COG1477	protein flavinylation
I8N73_RS14150	COG0473	3-isopropylmalate dehydrogenase activity
I8N73_RS14165	COG0440	acetolactate synthase activity
I8N73_RS14170	COG0028	Belongs to the TPP enzyme family
I8N73_RS14200	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I8N73_RS14220	COG0622	Phosphoesterase
I8N73_RS14225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8N73_RS14235	COG5401	PFAM Sporulation and spore germination
I8N73_RS14245	COG1846	Transcriptional regulator
I8N73_RS14250	COG2197	response regulator
I8N73_RS14255	COG0824	Thioesterase
I8N73_RS14260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8N73_RS14265	COG1053	succinate dehydrogenase
I8N73_RS14270	COG2009	succinate dehydrogenase
I8N73_RS14275	COG1719	4-vinyl reductase, 4VR
I8N73_RS14280	COG0527	aspartate kinase activity
I8N73_RS14290	COG3118	belongs to the thioredoxin family
I8N73_RS14295	COG3534	alpha-L-arabinofuranosidase
I8N73_RS14300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I8N73_RS14305	COG2086	electron transfer activity
I8N73_RS14310	COG1024	Enoyl-CoA hydratase
I8N73_RS14315	COG1309	transcriptional regulator
I8N73_RS14320	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_RS14330	COG3766	membrane
I8N73_RS14340	COG1796	DNA polymerase
I8N73_RS14340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N73_RS14345	COG1286	toxin biosynthetic process
I8N73_RS14365	COG0072	phenylalanine-tRNA ligase activity
I8N73_RS14365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_RS14370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8N73_RS14375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N73_RS14385	COG3835	regulator
I8N73_RS14390	COG0277	FAD linked oxidase domain protein
I8N73_RS14395	COG0247	lactate metabolic process
I8N73_RS14400	COG1966	Carbon starvation protein
I8N73_RS14405	COG3534	alpha-L-arabinofuranosidase
I8N73_RS14410	COG0395	ABC-type sugar transport system, permease component
I8N73_RS14415	COG1175	transmembrane transport
I8N73_RS14420	COG1653	transport
I8N73_RS14430	COG0647	UMP catabolic process
I8N73_RS14435	COG0235	Class ii aldolase
I8N73_RS14440	COG1069	ribulokinase activity
I8N73_RS14445	COG2160	L-arabinose isomerase activity
I8N73_RS14450	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_RS14455	COG1363	Peptidase, m42
I8N73_RS14465	COG3326	Membrane
I8N73_RS14470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8N73_RS14480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8N73_RS14485	COG1346	cytolysis
I8N73_RS14490	COG1380	Effector of murein hydrolase LrgA
I8N73_RS14495	COG3279	Response regulator of the LytR AlgR family
I8N73_RS14500	COG3275	phosphorelay sensor kinase activity
I8N73_RS14505	COG1011	Hydrolase
I8N73_RS14520	COG0398	Pfam SNARE associated Golgi protein
I8N73_RS14525	COG1484	DNA-dependent DNA replication
I8N73_RS14530	COG3611	Membrane attachment protein
I8N73_RS14545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N73_RS14550	COG1733	regulation of RNA biosynthetic process
I8N73_RS14555	COG2814	Major facilitator Superfamily
I8N73_RS14560	COG0656	L-ascorbic acid biosynthetic process
I8N73_RS14565	COG0237	dephospho-CoA kinase activity
I8N73_RS14570	COG1971	Probably functions as a manganese efflux pump
I8N73_RS14575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8N73_RS14580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_RS14580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_RS14585	COG5002	protein histidine kinase activity
I8N73_RS14590	COG0745	RESPONSE REGULATOR receiver
I8N73_RS14600	COG0538	isocitrate dehydrogenase activity
I8N73_RS14605	COG0372	Belongs to the citrate synthase family
I8N73_RS14625	COG0628	permease
I8N73_RS14630	COG3030	protein affecting phage T7 exclusion by the F plasmid
I8N73_RS14635	COG0469	pyruvate kinase activity
I8N73_RS14655	COG0281	malic enzyme
I8N73_RS14660	COG0587	DNA-directed DNA polymerase activity
I8N73_RS14680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I8N73_RS14690	COG4109	DRTGG domain
I8N73_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS14715	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8N73_RS14725	COG0827	DNA restriction-modification system
I8N73_RS14730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I8N73_RS14735	COG3874	Sporulation protein YtfJ
I8N73_RS14745	COG1714	RDD family
I8N73_RS14750	COG0616	signal peptide processing
I8N73_RS14755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N73_RS14760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8N73_RS14765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N73_RS14780	COG1104	cysteine desulfurase activity
I8N73_RS14785	COG1114	Component of the transport system for branched-chain amino acids
I8N73_RS14795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N73_RS14800	COG1309	transcriptional regulator
I8N73_RS14805	COG1956	GAF domain-containing protein
I8N73_RS14810	COG2203	Gaf domain
I8N73_RS14810	COG2199	diguanylate cyclase activity
I8N73_RS14820	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS14825	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_RS14840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N73_RS14840	COG1017	nitric oxide dioxygenase activity
I8N73_RS14865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_RS14870	COG1378	Sugar-specific transcriptional regulator TrmB
I8N73_RS14890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N73_RS14895	COG0454	-acetyltransferase
I8N73_RS14900	COG0517	IMP dehydrogenase activity
I8N73_RS14905	COG0123	including yeast histone deacetylase and acetoin utilization protein
I8N73_RS14910	COG1360	Flagellar Motor Protein
I8N73_RS14915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N73_RS14920	COG1609	Transcriptional regulator
I8N73_RS14925	COG1605	Chorismate mutase
I8N73_RS14925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I8N73_RS14930	COG3118	belongs to the thioredoxin family
I8N73_RS14935	COG4980	gas vesicle protein
I8N73_RS14940	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N73_RS14950	COG1674	ftsk spoiiie
I8N73_RS14955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_RS14965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS14975	COG1363	Peptidase, m42
I8N73_RS14980	COG5584	Small secreted protein
I8N73_RS14985	COG0281	malic enzyme
I8N73_RS14990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_RS15005	COG0510	thiamine kinase activity
I8N73_RS15010	COG1597	lipid kinase activity
I8N73_RS15020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I8N73_RS15025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_RS15030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_RS15035	COG2252	PERMEase
I8N73_RS15040	COG4473	ABC transporter
I8N73_RS15045	COG1131	(ABC) transporter
I8N73_RS15050	COG1349	DNA-binding transcription factor activity
I8N73_RS15055	COG1187	pseudouridine synthase activity
I8N73_RS15060	COG2244	polysaccharide biosynthetic process
I8N73_RS15065	COG2081	HI0933 family
I8N73_RS15070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N73_RS15080	COG1609	Transcriptional regulator
I8N73_RS15085	COG1653	transport
I8N73_RS15090	COG1175	transmembrane transport
I8N73_RS15095	COG0395	ABC-type sugar transport system, permease component
I8N73_RS15100	COG1486	melibiose metabolic process
I8N73_RS15110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N73_RS15125	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_RS15125	COG2202	Pas domain
I8N73_RS15130	COG2814	Major facilitator Superfamily
I8N73_RS15135	COG5522	Integral membrane protein (intg_mem_TP0381)
I8N73_RS15140	COG0577	efflux transmembrane transporter activity
I8N73_RS15145	COG1136	(ABC) transporter
I8N73_RS15150	COG2205	protein histidine kinase activity
I8N73_RS15155	COG0745	RESPONSE REGULATOR receiver
I8N73_RS15160	COG0577	efflux transmembrane transporter activity
I8N73_RS15165	COG1136	(ABC) transporter
I8N73_RS15185	COG1131	(ABC) transporter
I8N73_RS15190	COG1725	Transcriptional regulator
I8N73_RS15200	COG0640	Transcriptional regulator
I8N73_RS15205	COG0477	Major facilitator Superfamily
I8N73_RS15210	COG1242	4 iron, 4 sulfur cluster binding
I8N73_RS15215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I8N73_RS15225	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_RS15235	COG2267	carboxylic ester hydrolase activity
I8N73_RS15240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I8N73_RS15245	COG1113	amino acid transport
I8N73_RS15250	COG0367	asparagine synthase
I8N73_RS15270	COG1506	peptidase
I8N73_RS15275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N73_RS15280	COG1116	anion transmembrane transporter activity
I8N73_RS15285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N73_RS15290	COG0494	nUDIX hydrolase
I8N73_RS15295	COG4824	toxin secretion phage lysis holin
I8N73_RS15300	COG0783	Belongs to the Dps family
I8N73_RS15325	COG0288	reversible hydration of carbon dioxide
I8N73_RS15335	COG1271	oxidase subunit
I8N73_RS15340	COG1294	oxidase, subunit
I8N73_RS15350	COG4948	Mandelate Racemase Muconate Lactonizing
I8N73_RS15360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8N73_RS15365	COG0596	Alpha beta hydrolase
I8N73_RS15375	COG1169	isochorismate synthase
I8N73_RS15380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_RS15385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I8N73_RS15510	COG3859	Proton-coupled thiamine transporter YuaJ
I8N73_RS15515	COG2268	Band 7 protein
I8N73_RS15520	COG1585	Membrane protein implicated in regulation of membrane protease activity
I8N73_RS15525	COG2318	DinB family
I8N73_RS15535	COG1454	alcohol dehydrogenase
I8N73_RS15540	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS15545	COG1510	regulation of RNA biosynthetic process
I8N73_RS15555	COG0569	domain protein
I8N73_RS15560	COG1705	Flagellar rod assembly protein muramidase FlgJ
I8N73_RS15565	COG1017	nitric oxide dioxygenase activity
I8N73_RS15565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N73_RS15590	COG0628	permease
I8N73_RS15595	COG0673	inositol 2-dehydrogenase activity
I8N73_RS15600	COG0693	protein deglycase activity
I8N73_RS15605	COG0840	transmembrane signaling receptor activity
I8N73_RS15610	COG0840	transmembrane signaling receptor activity
I8N73_RS15615	COG0840	transmembrane signaling receptor activity
I8N73_RS15620	COG0840	transmembrane signaling receptor activity
I8N73_RS15635	COG2070	2-Nitropropane dioxygenase
I8N73_RS15640	COG0432	Pfam Uncharacterised protein family UPF0047
I8N73_RS15645	COG0366	Alpha amylase catalytic
I8N73_RS15650	COG1253	flavin adenine dinucleotide binding
I8N73_RS15655	COG2738	Putative neutral zinc metallopeptidase
I8N73_RS15670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8N73_RS15695	COG1335	isochorismatase
I8N73_RS15700	COG1979	alcohol dehydrogenase
I8N73_RS15705	COG1979	alcohol dehydrogenase
I8N73_RS15710	COG2155	Conserved Protein
I8N73_RS15715	COG1098	S1 RNA binding domain
I8N73_RS15720	COG0436	Aminotransferase
I8N73_RS15725	COG1522	sequence-specific DNA binding
I8N73_RS15730	COG2267	carboxylic ester hydrolase activity
I8N73_RS15740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8N73_RS15745	COG2205	protein histidine kinase activity
I8N73_RS15755	COG5018	Exonuclease
I8N73_RS15760	COG2814	Major facilitator Superfamily
I8N73_RS15765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_RS15770	COG3011	Protein conserved in bacteria
I8N73_RS15780	COG3290	protein histidine kinase activity
I8N73_RS15785	COG4565	transcriptional regulatory protein
I8N73_RS15790	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_RS15795	COG3845	ABC transporter
I8N73_RS15800	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8N73_RS15805	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8N73_RS15815	COG2111	Na H antiporter
I8N73_RS15815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8N73_RS15820	COG2111	Na H antiporter
I8N73_RS15825	COG1006	Multisubunit Na H antiporter MnhC subunit
I8N73_RS15830	COG0651	ATP synthesis coupled electron transport
I8N73_RS15835	COG1863	multisubunit Na H antiporter MnhE subunit
I8N73_RS15840	COG2212	antiporter activity
I8N73_RS15845	COG1320	monovalent cation:proton antiporter activity
I8N73_RS15850	COG2050	protein possibly involved in aromatic compounds catabolism
I8N73_RS15855	COG2197	response regulator
I8N73_RS15860	COG4585	Histidine kinase
I8N73_RS15870	COG0142	geranyltranstransferase activity
I8N73_RS15885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I8N73_RS15890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I8N73_RS15895	COG1335	isochorismatase
I8N73_RS15900	COG5506	Protein of unknown function (DUF1694)
I8N73_RS15915	COG0628	permease
I8N73_RS15925	COG1418	mRNA catabolic process
I8N73_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS15940	COG1511	domain protein
I8N73_RS15945	COG1674	ftsk spoiiie
I8N73_RS15945	COG0433	COG0433 Predicted ATPase
I8N73_RS15950	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N73_RS15955	COG5417	Belongs to the EsaB family
I8N73_RS15960	COG4842	Belongs to the WXG100 family
I8N73_RS15965	COG2508	Transcriptional regulator
I8N73_RS15965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I8N73_RS15970	COG0686	Belongs to the AlaDH PNT family
I8N73_RS15975	COG5634	Uncharacterized conserved protein (DUF2278)
I8N73_RS15980	COG3251	PFAM MbtH domain protein
I8N73_RS15985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_RS15990	COG3433	isochorismatase activity
I8N73_RS15990	COG1535	isochorismatase
I8N73_RS15995	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8N73_RS16000	COG1169	isochorismate synthase
I8N73_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS16010	COG2819	hydrolase of the alpha beta superfamily
I8N73_RS16015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N73_RS16020	COG1268	BioY protein
I8N73_RS16025	COG2056	Na+-H+ antiporter family
I8N73_RS16035	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I8N73_RS16040	COG3584	3D domain protein
I8N73_RS16055	COG1252	NADH dehydrogenase
I8N73_RS16085	COG1131	(ABC) transporter
I8N73_RS16105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_RS16110	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I8N73_RS16115	COG0316	Belongs to the HesB IscA family
I8N73_RS16125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_RS16135	COG1252	NADH dehydrogenase
I8N73_RS16140	COG4837	Protein of unknown function (DUF1462)
I8N73_RS16145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I8N73_RS16150	COG0823	Involved in the tonB-independent uptake of proteins
I8N73_RS16150	COG4946	Tricorn protease homolog
I8N73_RS16150	COG1506	peptidase
I8N73_RS16160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8N73_RS16165	COG0460	homoserine dehydrogenase
I8N73_RS16170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_RS16175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8N73_RS16180	COG0647	UMP catabolic process
I8N73_RS16185	COG2445	Protein of unknown function DUF86
I8N73_RS16190	COG4470	Protein conserved in bacteria
I8N73_RS16200	COG0739	heme binding
I8N73_RS16210	COG0737	Belongs to the 5'-nucleotidase family
I8N73_RS16215	COG0730	response to heat
I8N73_RS16220	COG1801	Protein of unknown function DUF72
I8N73_RS16235	COG2508	Transcriptional regulator
I8N73_RS16250	COG2814	Major facilitator Superfamily
I8N73_RS16255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8N73_RS16260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_RS16265	COG2356	endonuclease I
I8N73_RS16270	COG3842	ATPase activity
I8N73_RS16275	COG2188	Transcriptional regulator
I8N73_RS16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_RS16285	COG0395	ABC-type sugar transport system, permease component
I8N73_RS16290	COG1175	transmembrane transport
I8N73_RS16295	COG1653	transport
I8N73_RS16300	COG2222	sugar isomerase
I8N73_RS16305	COG0789	Transcriptional regulator
I8N73_RS16330	COG0322	excinuclease ABC activity
I8N73_RS16335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_RS16340	COG2226	methyltransferase
I8N73_RS16350	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS16355	COG0719	Fe-S assembly protein
I8N73_RS16360	COG0822	iron-sulfur transferase activity
I8N73_RS16365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N73_RS16370	COG0719	Fe-S assembly protein
I8N73_RS16375	COG0396	ATPase activity
I8N73_RS16385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N73_RS16390	COG1464	Belongs to the NlpA lipoprotein family
I8N73_RS16395	COG2011	ABC-type metal ion transport system permease component
I8N73_RS16400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8N73_RS16410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_RS16415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N73_RS16430	COG1393	Belongs to the ArsC family
I8N73_RS16435	COG1960	acyl-CoA dehydrogenase activity
I8N73_RS16440	COG0183	Belongs to the thiolase family
I8N73_RS16445	COG1024	Enoyl-CoA hydratase
I8N73_RS16445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N73_RS16460	COG0477	Major facilitator Superfamily
I8N73_RS16470	COG5577	PFAM Coat F domain
I8N73_RS16475	COG1846	Transcriptional regulator
I8N73_RS16480	COG0477	Major facilitator Superfamily
I8N73_RS16485	COG0583	DNA-binding transcription factor activity
I8N73_RS16510	COG1120	ATPase activity
I8N73_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS16530	COG0783	Belongs to the Dps family
I8N73_RS16535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_RS16540	COG0745	RESPONSE REGULATOR receiver
I8N73_RS16545	COG2205	protein histidine kinase activity
I8N73_RS16545	COG2770	Histidine kinase
I8N73_RS16555	COG1309	transcriptional regulator
I8N73_RS16560	COG0114	fumarate hydratase activity
I8N73_RS16570	COG0697	spore germination
I8N73_RS16575	COG0814	amino acid
I8N73_RS16585	COG2197	response regulator
I8N73_RS16590	COG4585	Histidine kinase
I8N73_RS16595	COG4758	membrane
I8N73_RS16600	COG3595	metallopeptidase activity
I8N73_RS16605	COG1842	Phage shock protein A
I8N73_RS16610	COG4758	membrane
I8N73_RS16615	COG2814	Major facilitator Superfamily
I8N73_RS16620	COG2096	Adenosyltransferase
I8N73_RS16625	COG1120	ATPase activity
I8N73_RS16630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS16635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS16645	COG3386	PFAM SMP-30 Gluconolaconase
I8N73_RS16650	COG2205	protein histidine kinase activity
I8N73_RS16655	COG0745	RESPONSE REGULATOR receiver
I8N73_RS16665	COG1191	sigma factor activity
I8N73_RS16675	COG2140	Oxalate decarboxylase
I8N73_RS16685	COG1120	ATPase activity
I8N73_RS16690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS16695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS16700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_RS16705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8N73_RS16710	COG0531	amino acid
I8N73_RS16720	COG1988	membrane-bound metal-dependent
I8N73_RS16725	COG1368	sulfuric ester hydrolase activity
I8N73_RS16730	COG1910	domain protein
I8N73_RS16735	COG0725	ABC transporter, periplasmic molybdate-binding protein
I8N73_RS16740	COG4149	molybdate abc transporter
I8N73_RS16745	COG2197	response regulator
I8N73_RS16750	COG3850	Histidine kinase
I8N73_RS16755	COG1131	(ABC) transporter
I8N73_RS16765	COG0842	Transport permease protein
I8N73_RS16770	COG0656	L-ascorbic acid biosynthetic process
I8N73_RS16790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_RS16795	COG3973	AAA domain
I8N73_RS16800	COG2860	membrane
I8N73_RS16810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I8N73_RS16815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8N73_RS16820	COG2217	Heavy metal translocating P-type atpase
I8N73_RS16825	COG2217	Heavy metal translocating P-type atpase
I8N73_RS16830	COG2608	mercury ion transmembrane transporter activity
I8N73_RS16835	COG1937	Protein conserved in bacteria
I8N73_RS16840	COG0673	inositol 2-dehydrogenase activity
I8N73_RS16850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS16855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I8N73_RS16860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS16865	COG1126	abc transporter atp-binding protein
I8N73_RS16870	COG0765	amino acid transport
I8N73_RS16875	COG0765	amino acid transport
I8N73_RS16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS16885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_RS16890	COG0454	-acetyltransferase
I8N73_RS16895	COG0583	DNA-binding transcription factor activity
I8N73_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS16905	COG2732	(Barnase) inhibitor
I8N73_RS16910	COG2732	(Barnase) inhibitor
I8N73_RS16925	COG0557	exoribonuclease II activity
I8N73_RS16930	COG1647	Serine aminopeptidase, S33
I8N73_RS16935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N73_RS16940	COG1476	TRANSCRIPTIONal
I8N73_RS16945	COG1396	sequence-specific DNA binding
I8N73_RS16950	COG1396	sequence-specific DNA binding
I8N73_RS16955	COG1733	regulation of RNA biosynthetic process
I8N73_RS16980	COG1131	(ABC) transporter
I8N73_RS16985	COG1174	glycine betaine transport
I8N73_RS16990	COG1732	Glycine betaine
I8N73_RS16995	COG1174	glycine betaine transport
I8N73_RS17000	COG1125	glycine betaine transport
I8N73_RS17000	COG0517	IMP dehydrogenase activity
I8N73_RS17005	COG1510	regulation of RNA biosynthetic process
I8N73_RS17010	COG1174	glycine betaine transport
I8N73_RS17015	COG1732	Glycine betaine
I8N73_RS17020	COG1174	glycine betaine transport
I8N73_RS17025	COG1125	glycine betaine transport
I8N73_RS17025	COG0517	IMP dehydrogenase activity
I8N73_RS17030	COG1510	regulation of RNA biosynthetic process
I8N73_RS17035	COG2095	MarC family integral membrane protein
I8N73_RS17040	COG3064	Membrane
I8N73_RS17045	COG4640	response to antibiotic
I8N73_RS17050	COG0456	acetyltransferase
I8N73_RS17065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_RS17080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_RS17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_RS17090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_RS17100	COG2234	aminopeptidase activity
I8N73_RS17120	COG0126	phosphoglycerate kinase activity
I8N73_RS17125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N73_RS17130	COG2390	Transcriptional regulator
I8N73_RS17135	COG2814	Major facilitator Superfamily
I8N73_RS17140	COG1609	Transcriptional regulator
I8N73_RS17145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS17155	COG0583	DNA-binding transcription factor activity
I8N73_RS17160	COG0697	spore germination
I8N73_RS17175	COG1609	Transcriptional regulator
I8N73_RS17185	COG0561	phosphatase activity
I8N73_RS17190	COG1737	Transcriptional regulator
I8N73_RS17195	COG1070	Carbohydrate kinase
I8N73_RS17220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS17225	COG2186	Transcriptional regulator
I8N73_RS17230	COG1620	l-lactate permease
I8N73_RS17235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I8N73_RS17245	COG5039	Polysaccharide pyruvyl transferase
I8N73_RS17250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_RS17255	COG0110	maltose O-acetyltransferase activity
I8N73_RS17260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8N73_RS17265	COG2244	polysaccharide biosynthetic process
I8N73_RS17270	COG1216	Glycosyl transferase, family 2
I8N73_RS17275	COG5039	Polysaccharide pyruvyl transferase
I8N73_RS17280	COG1216	Glycosyl transferase, family 2
I8N73_RS17290	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS17295	COG1215	transferase activity, transferring glycosyl groups
I8N73_RS17300	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS17305	COG1086	Polysaccharide biosynthesis protein
I8N73_RS17310	COG0489	protein tyrosine kinase activity
I8N73_RS17315	COG3944	biosynthesis protein
I8N73_RS17320	COG1396	sequence-specific DNA binding
I8N73_RS17325	COG2272	Belongs to the type-B carboxylesterase lipase family
I8N73_RS17330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_RS17335	COG2364	Membrane
I8N73_RS17340	COG0456	acetyltransferase
I8N73_RS17345	COG3479	Phenolic acid decarboxylase
I8N73_RS17395	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N73_RS17415	COG2223	nitrite transmembrane transporter activity
I8N73_RS17420	COG1609	Transcriptional regulator
I8N73_RS17430	COG0583	DNA-binding transcription factor activity
I8N73_RS17435	COG2828	Protein conserved in bacteria
I8N73_RS17440	COG0477	Major facilitator Superfamily
I8N73_RS17440	COG2814	Major facilitator Superfamily
I8N73_RS17445	COG1611	Belongs to the LOG family
I8N73_RS17450	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N73_RS17455	COG0659	secondary active sulfate transmembrane transporter activity
I8N73_RS17460	COG0288	reversible hydration of carbon dioxide
I8N73_RS17465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N73_RS17470	COG4290	ribonuclease
I8N73_RS17475	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I8N73_RS17480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS17490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8N73_RS17500	COG1051	belongs to the nudix hydrolase family
I8N73_RS17505	COG0492	ferredoxin-NADP+ reductase activity
I8N73_RS17510	COG3883	PFAM NLP P60 protein
I8N73_RS17510	COG0791	NLP P60 protein
I8N73_RS17515	COG0457	Tetratricopeptide repeat
I8N73_RS17520	COG5002	protein histidine kinase activity
I8N73_RS17525	COG0745	RESPONSE REGULATOR receiver
I8N73_RS17530	COG1132	(ABC) transporter
I8N73_RS17535	COG0140	phosphoribosyl-ATP diphosphatase activity
I8N73_RS17535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8N73_RS17560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8N73_RS17575	COG4990	cell redox homeostasis
I8N73_RS17580	COG0110	maltose O-acetyltransferase activity
I8N73_RS17600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8N73_RS17610	COG2188	Transcriptional regulator
I8N73_RS17615	COG1309	transcriptional regulator
I8N73_RS17620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N73_RS17625	COG1950	PFAM Membrane protein of
I8N73_RS17630	COG1983	PspC domain protein
I8N73_RS17635	COG3595	metallopeptidase activity
I8N73_RS17650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8N73_RS17660	COG4897	Protein conserved in bacteria
I8N73_RS17665	COG3848	Pyruvate phosphate dikinase
I8N73_RS17665	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_RS17670	COG1309	transcriptional regulator
I8N73_RS17675	COG2814	Major facilitator Superfamily
I8N73_RS17685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_RS17695	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_RS17695	COG0793	Belongs to the peptidase S41A family
I8N73_RS17700	COG3420	alginic acid biosynthetic process
I8N73_RS17705	COG2177	Part of the ABC transporter FtsEX involved in
I8N73_RS17710	COG2884	Cell division ATP-binding protein ftsE
I8N73_RS17715	COG2010	Cytochrome c
I8N73_RS17720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS17735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8N73_RS17750	COG1516	flagellar protein fliS
I8N73_RS17755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I8N73_RS17760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N73_RS17780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N73_RS17785	COG4786	Flagellar basal body rod
I8N73_RS17785	COG1256	bacterial-type flagellum assembly
I8N73_RS17790	COG3418	PFAM FlgN family protein
I8N73_RS17795	COG2747	anti-sigma28 factor FlgM
I8N73_RS17805	COG1040	competence protein
I8N73_RS17815	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I8N73_RS17820	COG1307	EDD domain protein, DegV family
I8N73_RS17825	COG2197	response regulator
I8N73_RS17830	COG4585	Histidine kinase
I8N73_RS17835	COG1739	Uncharacterized protein family UPF0029
I8N73_RS17840	COG1316	TRANSCRIPTIONal
I8N73_RS17845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8N73_RS17850	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS17855	COG1215	transferase activity, transferring glycosyl groups
I8N73_RS17860	COG3206	protein involved in exopolysaccharide biosynthesis
I8N73_RS17865	COG3307	-O-antigen
I8N73_RS17870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N73_RS17875	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS17875	COG0297	glycogen (starch) synthase activity
I8N73_RS17880	COG2244	polysaccharide biosynthetic process
I8N73_RS17890	COG2247	cell wall binding repeat
I8N73_RS17890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_RS17895	COG2385	sporulation resulting in formation of a cellular spore
I8N73_RS17895	COG2247	cell wall binding repeat
I8N73_RS17905	COG1316	TRANSCRIPTIONal
I8N73_RS17910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I8N73_RS17915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N73_RS17920	COG1134	teichoic acid transport
I8N73_RS17925	COG1682	transport, permease protein
I8N73_RS17930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_RS17935	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS17940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8N73_RS17945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I8N73_RS17950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_RS17955	COG4193	domain, Protein
I8N73_RS17960	COG1482	cell wall glycoprotein biosynthetic process
I8N73_RS17965	COG0697	spore germination
I8N73_RS17970	COG0814	amino acid
I8N73_RS17980	COG1215	transferase activity, transferring glycosyl groups
I8N73_RS17985	COG2814	Major facilitator Superfamily
I8N73_RS17990	COG1316	TRANSCRIPTIONal
I8N73_RS17995	COG0561	phosphatase activity
I8N73_RS18000	COG2433	Pfam Transposase IS66
I8N73_RS18005	COG0791	NLP P60 protein
I8N73_RS18015	COG2843	Capsule synthesis protein
I8N73_RS18025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8N73_RS18030	COG0697	spore germination
I8N73_RS18035	COG0814	amino acid
I8N73_RS18045	COG1609	Transcriptional regulator
I8N73_RS18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_RS18060	COG1129	ABC transporter
I8N73_RS18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8N73_RS18070	COG1879	ABC-type sugar transport system periplasmic component
I8N73_RS18075	COG3103	Sh3 type 3 domain protein
I8N73_RS18080	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_RS18085	COG3527	Alpha-acetolactate decarboxylase
I8N73_RS18090	COG0028	Belongs to the TPP enzyme family
I8N73_RS18095	COG0583	DNA-binding transcription factor activity
I8N73_RS18100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N73_RS18115	COG5337	Spore coat protein CotH
I8N73_RS18125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8N73_RS18135	COG0405	Gamma-glutamyltransferase
I8N73_RS18140	COG1522	sequence-specific DNA binding
I8N73_RS18145	COG2059	Chromate
I8N73_RS18150	COG2059	Chromate
I8N73_RS18175	COG5444	nuclease activity
I8N73_RS18190	COG3878	Protein conserved in bacteria
I8N73_RS18195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N73_RS18200	COG4464	protein tyrosine phosphatase activity
I8N73_RS18205	COG0489	protein tyrosine kinase activity
I8N73_RS18210	COG3944	biosynthesis protein
I8N73_RS18220	COG4715	Zinc finger, swim domain protein
I8N73_RS18225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N73_RS18230	COG0561	phosphatase activity
I8N73_RS18235	COG1349	DNA-binding transcription factor activity
I8N73_RS18240	COG0629	single-stranded DNA binding
I8N73_RS18265	COG0457	Tetratricopeptide repeat
I8N73_RS18270	COG4786	Flagellar basal body rod
I8N73_RS18275	COG4786	Flagellar basal body rod
I8N73_RS18280	COG1077	Cell shape determining protein MreB Mrl
I8N73_RS18285	COG1609	Transcriptional regulator
I8N73_RS18290	COG1846	Transcriptional regulator
I8N73_RS18295	COG2814	Major facilitator Superfamily
I8N73_RS18300	COG1953	Uracil, thiamine, allantoin
I8N73_RS18305	COG0477	Major facilitator Superfamily
I8N73_RS18310	COG1335	isochorismatase
I8N73_RS18315	COG0004	ammonium transporteR
I8N73_RS18320	COG0347	Belongs to the P(II) protein family
I8N73_RS18325	COG0772	Belongs to the SEDS family
I8N73_RS18330	COG0671	phosphoesterase, PA-phosphatase related
I8N73_RS18340	COG0739	heme binding
I8N73_RS18345	COG1247	-acetyltransferase
I8N73_RS18360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_RS18370	COG0726	polysaccharide deacetylase
I8N73_RS18375	COG1959	2 iron, 2 sulfur cluster binding
I8N73_RS18390	COG0831	urea catabolic process
I8N73_RS18400	COG1994	Peptidase M50
I8N73_RS18405	COG0457	Tetratricopeptide repeat
I8N73_RS18415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8N73_RS18425	COG2304	oxidoreductase activity
I8N73_RS18430	COG2304	oxidoreductase activity
I8N73_RS18435	COG2385	sporulation resulting in formation of a cellular spore
I8N73_RS18440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N73_RS18450	COG4836	Membrane
I8N73_RS18520	COG0698	ribose 5-phosphate isomerase
I8N73_RS18525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N73_RS18535	COG0009	L-threonylcarbamoyladenylate synthase
I8N73_RS18540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8N73_RS18560	COG2890	protein-(glutamine-N5) methyltransferase activity
I8N73_RS18565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8N73_RS18570	COG0346	lactoylglutathione lyase activity
I8N73_RS18575	COG0789	Transcriptional regulator
I8N73_RS18580	COG0679	Auxin Efflux Carrier
I8N73_RS18585	COG0281	malic enzyme
I8N73_RS18600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I8N73_RS18605	COG1494	fructose-1,6-bisphosphatase
I8N73_RS18610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N73_RS18620	COG0191	fructose-bisphosphate aldolase activity
I8N73_RS18625	COG2204	response regulator
I8N73_RS18630	COG4821	SIS domain
I8N73_RS18645	COG0247	lactate metabolic process
I8N73_RS18645	COG2181	nitrate reductase activity
I8N73_RS18650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_RS18665	COG1132	(ABC) transporter
I8N73_RS18670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_RS18680	COG2181	nitrate reductase activity
I8N73_RS18685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I8N73_RS18690	COG1140	nitrate reductase beta subunit
I8N73_RS18695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I8N73_RS18700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_RS18710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_RS18715	COG2223	nitrite transmembrane transporter activity
I8N73_RS18725	COG4506	Protein conserved in bacteria
I8N73_RS18735	COG3391	amine dehydrogenase activity
I8N73_RS18740	COG3391	amine dehydrogenase activity
I8N73_RS18745	COG0457	Tetratricopeptide repeat
I8N73_RS18785	COG0010	Belongs to the arginase family
I8N73_RS18790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I8N73_RS18795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_RS18810	COG1994	Peptidase M50
I8N73_RS18815	COG1942	4-Oxalocrotonate Tautomerase
I8N73_RS18820	COG1846	Transcriptional regulator
I8N73_RS18825	COG0531	amino acid
I8N73_RS18830	COG3465	dGTPase activity
I8N73_RS18835	COG1078	dGTPase activity
I8N73_RS18850	COG1695	Transcriptional regulator
I8N73_RS18860	COG1131	(ABC) transporter
I8N73_RS18865	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_RS18895	COG0583	DNA-binding transcription factor activity
I8N73_RS18900	COG2855	membrane
I8N73_RS18905	COG0280	phosphate acetyltransferase
I8N73_RS18915	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS18920	COG0436	Aminotransferase
I8N73_RS18950	COG2814	Major facilitator Superfamily
I8N73_RS18955	COG2814	Major facilitator Superfamily
I8N73_RS18960	COG0833	amino acid
I8N73_RS18965	COG4187	Peptidase family M20/M25/M40
I8N73_RS18970	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS18975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_RS18985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I8N73_RS18990	COG1091	dTDP-4-dehydrorhamnose reductase activity
I8N73_RS18995	COG1088	dTDP-glucose 4,6-dehydratase activity
I8N73_RS19000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I8N73_RS19005	COG3980	spore coat polysaccharide biosynthesis protein
I8N73_RS19010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I8N73_RS19015	COG2089	acid synthase
I8N73_RS19020	COG0456	acetyltransferase
I8N73_RS19025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_RS19030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_RS19035	COG0463	Glycosyl transferase, family 2
I8N73_RS19045	COG2363	Small membrane protein
I8N73_RS19050	COG2233	PERMEase
I8N73_RS19065	COG1216	Glycosyl transferase, family 2
I8N73_RS19080	COG1695	Transcriptional regulator
I8N73_RS19085	COG0351	phosphomethylpyrimidine kinase
I8N73_RS19095	COG1621	beta-fructofuranosidase activity
I8N73_RS19100	COG1263	PTS System
I8N73_RS19100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS19105	COG3711	transcriptional antiterminator
I8N73_RS19115	COG1404	Belongs to the peptidase S8 family
I8N73_RS19120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_RS19125	COG0778	Nitroreductase
I8N73_RS19130	COG0772	Belongs to the SEDS family
I8N73_RS19135	COG0454	-acetyltransferase
I8N73_RS19155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N73_RS19160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N73_RS19165	COG2261	transglycosylase associated protein
I8N73_RS19170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N73_RS19175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N73_RS19180	COG2246	polysaccharide biosynthetic process
I8N73_RS19185	COG1309	transcriptional regulator
I8N73_RS19205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N73_RS19210	COG2837	iron assimilation
I8N73_RS19215	COG2822	iron ion transport
I8N73_RS19230	COG0583	DNA-binding transcription factor activity
I8N73_RS19240	COG1346	cytolysis
I8N73_RS19245	COG1131	(ABC) transporter
I8N73_RS19270	COG4895	conserved protein (DUF2196)
I8N73_RS19280	COG0789	Transcriptional regulator
I8N73_RS19285	COG5504	Zn-dependent protease
I8N73_RS19290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I8N73_RS19295	COG0346	lactoylglutathione lyase activity
I8N73_RS19300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS19305	COG1404	Belongs to the peptidase S8 family
I8N73_RS19310	COG1442	glycosyl transferase family 8
I8N73_RS19315	COG1846	Transcriptional regulator
I8N73_RS19320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8N73_RS19325	COG2357	RelA SpoT domain protein
I8N73_RS19330	COG1575	Belongs to the MenA family. Type 1 subfamily
I8N73_RS19345	COG1696	Membrane protein involved in D-alanine export
I8N73_RS19355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I8N73_RS19360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_RS19365	COG1486	melibiose metabolic process
I8N73_RS19370	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_RS19375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS19380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_RS19385	COG3711	transcriptional antiterminator
I8N73_RS19395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS19400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_RS19410	COG0640	Transcriptional regulator
I8N73_RS19415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N73_RS19420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS19425	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_RS19430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_RS19435	COG2723	6-phospho-beta-galactosidase activity
I8N73_RS19440	COG1940	carbohydrate kinase activity
I8N73_RS19445	COG1482	cell wall glycoprotein biosynthetic process
I8N73_RS19455	COG0753	catalase activity
I8N73_RS19460	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I8N73_RS19465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N73_RS19470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8N73_RS19475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I8N73_RS19480	COG4988	ABC transporter
I8N73_RS19485	COG1294	oxidase, subunit
I8N73_RS19490	COG1271	oxidase subunit
I8N73_RS19495	COG3493	citrate carrier protein
I8N73_RS19500	COG0726	polysaccharide deacetylase
I8N73_RS19505	COG3842	ATPase activity
I8N73_RS19510	COG2508	Transcriptional regulator
I8N73_RS19515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS19525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N73_RS19540	COG4894	glucomannan catabolic process
I8N73_RS19545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N73_RS19550	COG0500	methyltransferase
I8N73_RS19555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_RS19570	COG0693	protein deglycase activity
I8N73_RS19570	COG0753	catalase activity
I8N73_RS19575	COG2851	Citrate transporter
I8N73_RS19580	COG2273	Hydrolase Family 16
I8N73_RS19585	COG3711	transcriptional antiterminator
I8N73_RS19590	COG2270	Major facilitator Superfamily
I8N73_RS19595	COG0513	Belongs to the DEAD box helicase family
I8N73_RS19695	COG3209	COG3209 Rhs family protein
I8N73_RS19705	COG0697	spore germination
I8N73_RS19710	COG0589	response to stress
I8N73_RS19715	COG2723	6-phospho-beta-galactosidase activity
I8N73_RS19720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_RS19720	COG1263	PTS System
I8N73_RS19720	COG2190	(PTS) system
I8N73_RS19735	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_RS19760	COG0010	Belongs to the arginase family
I8N73_RS19765	COG0833	amino acid
I8N73_RS19770	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I8N73_RS19775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_RS19785	COG2390	Transcriptional regulator
I8N73_RS19790	COG0561	phosphatase activity
I8N73_RS19820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_RS19825	COG5294	Protein conserved in bacteria
I8N73_RS19830	COG0577	efflux transmembrane transporter activity
I8N73_RS19835	COG1136	(ABC) transporter
I8N73_RS19840	COG2205	protein histidine kinase activity
I8N73_RS19845	COG0745	RESPONSE REGULATOR receiver
I8N73_RS19860	COG1082	Xylose isomerase domain protein TIM barrel
I8N73_RS19870	COG2814	Major facilitator Superfamily
I8N73_RS19900	COG1349	DNA-binding transcription factor activity
I8N73_RS19905	COG0667	Aldo Keto reductase
I8N73_RS19915	COG2814	Major facilitator Superfamily
I8N73_RS19925	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS19930	COG2197	response regulator
I8N73_RS19935	COG4585	Histidine kinase
I8N73_RS19940	COG3239	Fatty acid desaturase
I8N73_RS19945	COG1309	transcriptional regulator
I8N73_RS19950	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_RS19955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8N73_RS19965	COG0640	Transcriptional regulator
I8N73_RS19970	COG2814	Major facilitator Superfamily
I8N73_RS19975	COG1714	RDD family
I8N73_RS19985	COG0450	alkyl hydroperoxide reductase
I8N73_RS19990	COG3634	alkyl hydroperoxide reductase activity
I8N73_RS19995	COG3177	Filamentation induced by cAMP protein fic
I8N73_RS20000	COG1113	amino acid transport
I8N73_RS20010	COG2080	2 iron, 2 sulfur cluster binding
I8N73_RS20025	COG2068	MobA-Related Protein
I8N73_RS20030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I8N73_RS20105	COG2003	Belongs to the UPF0758 family
I8N73_RS20145	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I8N73_RS20150	COG0667	Aldo Keto reductase
I8N73_RS20155	COG0456	acetyltransferase
I8N73_RS20160	COG0457	Tetratricopeptide repeat
I8N73_RS20165	COG0010	Belongs to the arginase family
I8N73_RS20170	COG0833	amino acid
I8N73_RS20175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N73_RS20180	COG5658	integral membrane protein
I8N73_RS20185	COG0640	Transcriptional regulator
I8N73_RS20190	COG3829	transcription factor binding
I8N73_RS20200	COG0488	(ABC) transporter
I8N73_RS20215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_RS20220	COG5002	protein histidine kinase activity
I8N73_RS20220	COG3850	Histidine kinase
I8N73_RS20225	COG0745	RESPONSE REGULATOR receiver
I8N73_RS20230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_RS20235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I8N73_RS20240	COG4853	Protein conserved in bacteria
I8N73_RS20245	COG4863	YycH protein
I8N73_RS20250	COG5002	protein histidine kinase activity
I8N73_RS20255	COG0745	RESPONSE REGULATOR receiver
I8N73_RS20285	COG0346	lactoylglutathione lyase activity
I8N73_RS20290	COG0305	Participates in initiation and elongation during chromosome replication
I8N73_RS20305	COG3093	addiction module antidote protein HigA
I8N73_RS20310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N73_RS20325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I8N73_RS20330	COG0438	transferase activity, transferring glycosyl groups
I8N73_RS20350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I8N73_RS20355	COG4241	membrane
I8N73_RS20365	COG5577	PFAM Coat F domain
I8N73_RS20370	COG1733	regulation of RNA biosynthetic process
I8N73_RS20380	COG0697	spore germination
I8N73_RS20385	COG1621	beta-fructofuranosidase activity
I8N73_RS20390	COG1621	beta-fructofuranosidase activity
I8N73_RS20395	COG1802	Transcriptional regulator
I8N73_RS20400	COG2318	DinB family
I8N73_RS20405	COG2211	Major facilitator Superfamily
I8N73_RS20410	COG0583	DNA-binding transcription factor activity
I8N73_RS20425	COG0778	Nitroreductase
I8N73_RS20430	COG1846	Transcriptional regulator
I8N73_RS20435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_RS20440	COG1846	Transcriptional regulator
I8N73_RS20445	COG2153	protein acetylation
I8N73_RS20455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N73_RS20460	COG0583	DNA-binding transcription factor activity
I8N73_RS20465	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_RS20475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_RS20480	COG0697	spore germination
I8N73_RS20485	COG1331	Highly conserved protein containing a thioredoxin domain
I8N73_RS20490	COG1266	CAAX protease self-immunity
I8N73_RS20495	COG2814	Major facilitator Superfamily
I8N73_RS20495	COG0477	Major facilitator Superfamily
I8N73_RS20500	COG0346	lactoylglutathione lyase activity
I8N73_RS20505	COG1609	Transcriptional regulator
I8N73_RS20510	COG0708	Exodeoxyribonuclease III
I8N73_RS20515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N73_RS20520	COG2169	Transcriptional regulator
I8N73_RS20530	COG0629	single-stranded DNA binding
I8N73_RS20540	COG0012	GTP binding
I8N73_RS20545	COG0243	molybdopterin cofactor binding
I8N73_RS20550	COG4481	Protein conserved in bacteria
I8N73_RS20555	COG3949	Membrane
I8N73_RS20570	COG1475	DNA binding
I8N73_RS20575	COG1192	Involved in chromosome partitioning
I8N73_RS20600	COG1847	R3H domain protein
I8N73_RS20605	COG0706	membrane insertase activity