locus-tag	class	description
HWH77_RS00020	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS00025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWH77_RS00030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWH77_RS00035	COG2610	gluconate transmembrane transporter activity
HWH77_RS00040	COG2124	cytochrome p450
HWH77_RS00060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWH77_RS00070	COG2246	polysaccharide biosynthetic process
HWH77_RS00075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWH77_RS00080	COG0586	Pfam SNARE associated Golgi protein
HWH77_RS00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWH77_RS00090	COG1024	Enoyl-CoA hydratase
HWH77_RS00095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWH77_RS00100	COG0511	ligase activity, forming carbon-carbon bonds
HWH77_RS00105	COG0439	Biotin carboxylase
HWH77_RS00110	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS00115	COG1960	acyl-CoA dehydrogenase activity
HWH77_RS00120	COG1649	PFAM Uncharacterised BCR, COG1649
HWH77_RS00130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWH77_RS00130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS00135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS00140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS00145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS00150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS00155	COG2027	D-alanyl-D-alanine carboxypeptidase
HWH77_RS00160	COG2017	converts alpha-aldose to the beta-anomer
HWH77_RS00165	COG0534	Mate efflux family protein
HWH77_RS00175	COG5444	nuclease activity
HWH77_RS00195	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS00195	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS00200	COG4824	toxin secretion phage lysis holin
HWH77_RS00220	COG5434	Belongs to the glycosyl hydrolase 28 family
HWH77_RS00225	COG1388	LysM domain
HWH77_RS00225	COG1705	Flagellar rod assembly protein muramidase FlgJ
HWH77_RS00300	COG4626	Terminase
HWH77_RS00300	COG1802	Transcriptional regulator
HWH77_RS00325	COG0582	viral genome integration into host DNA
HWH77_RS00330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HWH77_RS00435	COG0582	viral genome integration into host DNA
HWH77_RS00440	COG0166	Belongs to the GPI family
HWH77_RS00445	COG0405	Gamma-glutamyltransferase
HWH77_RS00450	COG2814	Major facilitator Superfamily
HWH77_RS00455	COG0640	Transcriptional regulator
HWH77_RS00470	COG0604	alcohol dehydrogenase
HWH77_RS00475	COG0493	'glutamate synthase
HWH77_RS00480	COG0069	glutamate synthase activity
HWH77_RS00480	COG0067	glutamate synthase
HWH77_RS00480	COG0070	glutamate synthase
HWH77_RS00485	COG0583	DNA-binding transcription factor activity
HWH77_RS00490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWH77_RS00505	COG0300	oxidoreductase activity
HWH77_RS00510	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWH77_RS00520	COG2814	Major facilitator Superfamily
HWH77_RS00525	COG1070	Carbohydrate kinase
HWH77_RS00530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWH77_RS00535	COG0243	molybdopterin cofactor binding
HWH77_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS00560	COG1733	regulation of RNA biosynthetic process
HWH77_RS00565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWH77_RS00575	COG1309	transcriptional regulator
HWH77_RS00580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS00590	COG0640	Transcriptional regulator
HWH77_RS00595	COG0741	lytic transglycosylase activity
HWH77_RS00600	COG2322	membrane
HWH77_RS00615	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWH77_RS00625	COG3584	3D domain protein
HWH77_RS00625	COG1388	LysM domain
HWH77_RS00630	COG0514	ATP-dependent DNA helicase (RecQ)
HWH77_RS00640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWH77_RS00645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWH77_RS00660	COG0071	Belongs to the small heat shock protein (HSP20) family
HWH77_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS00695	COG1657	PFAM Prenyltransferase squalene oxidase
HWH77_RS00700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWH77_RS00705	COG0733	neurotransmitter:sodium symporter activity
HWH77_RS00710	COG0385	Bile acid
HWH77_RS00715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS00720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWH77_RS00730	COG4548	von Willebrand factor, type A
HWH77_RS00735	COG0714	Associated with various cellular activities
HWH77_RS00740	COG2032	superoxide dismutase activity
HWH77_RS00745	COG0791	NLP P60 protein
HWH77_RS00745	COG1388	LysM domain
HWH77_RS00750	COG1819	glycosyl
HWH77_RS00755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWH77_RS00760	COG0534	Mate efflux family protein
HWH77_RS00765	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS00770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWH77_RS00775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWH77_RS00785	COG2962	Rard protein
HWH77_RS00800	COG1942	4-Oxalocrotonate Tautomerase
HWH77_RS00810	COG1733	regulation of RNA biosynthetic process
HWH77_RS00815	COG0778	Nitroreductase
HWH77_RS00820	COG0400	carboxylic ester hydrolase activity
HWH77_RS00825	COG0346	lactoylglutathione lyase activity
HWH77_RS00835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWH77_RS00845	COG2723	6-phospho-beta-galactosidase activity
HWH77_RS00850	COG2188	Transcriptional regulator
HWH77_RS00855	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS00855	COG0793	Belongs to the peptidase S41A family
HWH77_RS00860	COG2226	methyltransferase
HWH77_RS00870	COG1876	peptidase activity
HWH77_RS00890	COG0671	phosphoesterase, PA-phosphatase related
HWH77_RS00925	COG1509	lysine 2,3-aminomutase activity
HWH77_RS00930	COG0456	acetyltransferase
HWH77_RS00935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWH77_RS00940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWH77_RS00945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWH77_RS00950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWH77_RS00955	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HWH77_RS00965	COG0456	acetyltransferase
HWH77_RS00970	COG0463	Glycosyl transferase, family 2
HWH77_RS00985	COG4641	Protein conserved in bacteria
HWH77_RS00995	COG1086	Polysaccharide biosynthesis protein
HWH77_RS01035	COG1388	LysM domain
HWH77_RS01040	COG0457	Tetratricopeptide repeat
HWH77_RS01050	COG3391	amine dehydrogenase activity
HWH77_RS01085	COG5444	nuclease activity
HWH77_RS01090	COG4282	regulation of fungal-type cell wall biogenesis
HWH77_RS01100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWH77_RS01120	COG1846	Transcriptional regulator
HWH77_RS01125	COG4698	Protein conserved in bacteria
HWH77_RS01130	COG2755	lipolytic protein G-D-S-L family
HWH77_RS01135	COG1999	signal sequence binding
HWH77_RS01145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWH77_RS01150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HWH77_RS01155	COG1272	protein, Hemolysin III
HWH77_RS01160	COG0204	Acyl-transferase
HWH77_RS01165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWH77_RS01180	COG2521	methyltransferase
HWH77_RS01180	COG2136	Putative SAM-dependent methyltransferase
HWH77_RS01195	COG1413	lyase activity
HWH77_RS01200	COG1418	mRNA catabolic process
HWH77_RS01205	COG0386	Belongs to the glutathione peroxidase family
HWH77_RS01215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWH77_RS01225	COG1278	Cold shock
HWH77_RS01245	COG0328	RNA-DNA hybrid ribonuclease activity
HWH77_RS01250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HWH77_RS01255	COG0328	RNA-DNA hybrid ribonuclease activity
HWH77_RS01265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWH77_RS01280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWH77_RS01290	COG1755	Isoprenylcysteine carboxyl methyltransferase
HWH77_RS01295	COG3424	synthase
HWH77_RS01320	COG1335	isochorismatase
HWH77_RS01330	COG2233	PERMEase
HWH77_RS01340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HWH77_RS01345	COG1199	ATP-dependent helicase activity
HWH77_RS01360	COG0116	Belongs to the methyltransferase superfamily
HWH77_RS01390	COG3359	exonuclease
HWH77_RS01395	COG1111	helicase
HWH77_RS01395	COG1205	dead DEAH box helicase
HWH77_RS01400	COG2190	(PTS) system
HWH77_RS01405	COG0071	Belongs to the small heat shock protein (HSP20) family
HWH77_RS01445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWH77_RS01445	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWH77_RS01455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWH77_RS01460	COG3935	DnaD domain protein
HWH77_RS01470	COG0436	Aminotransferase
HWH77_RS01475	COG5353	protein conserved in bacteria
HWH77_RS01485	COG1199	ATP-dependent helicase activity
HWH77_RS01485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWH77_RS01515	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS01520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWH77_RS01535	COG1694	Mazg nucleotide pyrophosphohydrolase
HWH77_RS01540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS01545	COG2140	Oxalate decarboxylase
HWH77_RS01555	COG4347	Protein of unknown function (DUF1405)
HWH77_RS01560	COG2010	Cytochrome c
HWH77_RS01560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWH77_RS01565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWH77_RS01570	COG0723	plastoquinol--plastocyanin reductase activity
HWH77_RS01585	COG0457	Tetratricopeptide repeat
HWH77_RS01595	COG0287	Prephenate dehydrogenase
HWH77_RS01630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWH77_RS01635	COG4401	Chorismate mutase type I
HWH77_RS01650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HWH77_RS01655	COG0105	UTP biosynthetic process
HWH77_RS01660	COG0142	geranyltranstransferase activity
HWH77_RS01670	COG0142	geranyltranstransferase activity
HWH77_RS01685	COG0776	regulation of translation
HWH77_RS01690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWH77_RS01730	COG0539	negative regulation of cytoplasmic translation
HWH77_RS01745	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HWH77_RS01750	COG2959	enzyme of heme biosynthesis
HWH77_RS01755	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS01755	COG3773	Cell wall hydrolase
HWH77_RS01760	COG2339	peptidase activity
HWH77_RS01765	COG0492	ferredoxin-NADP+ reductase activity
HWH77_RS01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWH77_RS01775	COG4862	establishment of competence for transformation
HWH77_RS01780	COG1408	metallophosphoesterase
HWH77_RS01790	COG1388	LysM domain
HWH77_RS01795	COG1266	CAAX protease self-immunity
HWH77_RS01800	COG0514	ATP-dependent DNA helicase (RecQ)
HWH77_RS01805	COG4955	Helix-turn-helix domain
HWH77_RS01810	COG1141	Ferredoxin
HWH77_RS01815	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HWH77_RS01820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWH77_RS01830	COG1595	DNA-templated transcription, initiation
HWH77_RS01835	COG5002	protein histidine kinase activity
HWH77_RS01840	COG0745	RESPONSE REGULATOR receiver
HWH77_RS01845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWH77_RS01850	COG1333	cytochrome c biogenesis protein
HWH77_RS01855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS01860	COG1187	pseudouridine synthase activity
HWH77_RS01865	COG0700	Nucleoside recognition
HWH77_RS01870	COG2715	membrane protein required for spore maturation
HWH77_RS01875	COG1686	Belongs to the peptidase S11 family
HWH77_RS01900	COG1547	Domain of unknown function (DUF309)
HWH77_RS01905	COG0456	acetyltransferase
HWH77_RS01920	COG0307	riboflavin synthase, alpha
HWH77_RS01925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWH77_RS01925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWH77_RS01935	COG0681	Belongs to the peptidase S26 family
HWH77_RS01945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWH77_RS01950	COG4086	secreted protein
HWH77_RS01955	COG0019	diaminopimelate decarboxylase activity
HWH77_RS01960	COG0697	spore germination
HWH77_RS01975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWH77_RS01995	COG1191	sigma factor activity
HWH77_RS02005	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS02010	COG1686	Belongs to the peptidase S11 family
HWH77_RS02015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HWH77_RS02020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HWH77_RS02025	COG4974	Belongs to the 'phage' integrase family
HWH77_RS02035	COG0735	belongs to the Fur family
HWH77_RS02040	COG1300	Membrane
HWH77_RS02055	COG0281	malic enzyme
HWH77_RS02060	COG1757	Na H antiporter
HWH77_RS02065	COG1027	Aspartate ammonia-lyase
HWH77_RS02070	COG0252	asparaginase activity
HWH77_RS02075	COG1396	sequence-specific DNA binding
HWH77_RS02080	COG1379	DNA repair
HWH77_RS02085	COG0494	nUDIX hydrolase
HWH77_RS02095	COG0667	Aldo Keto reductase
HWH77_RS02105	COG1073	alpha beta
HWH77_RS02115	COG4918	Iron-sulphur cluster biosynthesis
HWH77_RS02120	COG0456	acetyltransferase
HWH77_RS02120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWH77_RS02125	COG2329	Antibiotic biosynthesis monooxygenase
HWH77_RS02130	COG0456	acetyltransferase
HWH77_RS02135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWH77_RS02150	COG0628	permease
HWH77_RS02160	COG0346	lactoylglutathione lyase activity
HWH77_RS02170	COG3048	D-serine ammonia-lyase activity
HWH77_RS02175	COG0300	oxidoreductase activity
HWH77_RS02180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS02185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWH77_RS02190	COG1024	Enoyl-CoA hydratase
HWH77_RS02195	COG3425	synthase
HWH77_RS02200	COG2124	cytochrome p450
HWH77_RS02205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS02205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02205	COG3321	synthase
HWH77_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS02210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS02210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02210	COG3321	synthase
HWH77_RS02210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS02215	COG0300	oxidoreductase activity
HWH77_RS02215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02215	COG3321	synthase
HWH77_RS02215	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS02220	COG0300	oxidoreductase activity
HWH77_RS02220	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS02220	COG3321	synthase
HWH77_RS02220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS02225	COG3321	synthase
HWH77_RS02225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS02230	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS02230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02230	COG3321	synthase
HWH77_RS02230	COG0300	oxidoreductase activity
HWH77_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS02235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS02235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS02235	COG3321	synthase
HWH77_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS02245	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS02260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWH77_RS02260	COG2070	2-Nitropropane dioxygenase
HWH77_RS02265	COG0250	Participates in transcription elongation, termination and antitermination
HWH77_RS02285	COG0596	Alpha beta hydrolase
HWH77_RS02300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWH77_RS02305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWH77_RS02320	COG0706	membrane insertase activity
HWH77_RS02325	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWH77_RS02330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWH77_RS02335	COG0346	lactoylglutathione lyase activity
HWH77_RS02345	COG1376	ErfK ybiS ycfS ynhG family protein
HWH77_RS02350	COG4129	membrane
HWH77_RS02355	COG1126	abc transporter atp-binding protein
HWH77_RS02360	COG0765	amino acid transport
HWH77_RS02365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS02375	COG1597	lipid kinase activity
HWH77_RS02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWH77_RS02385	COG0022	dehydrogenase e1 component
HWH77_RS02390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWH77_RS02395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWH77_RS02400	COG3426	butyrate kinase activity
HWH77_RS02405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWH77_RS02410	COG0280	phosphate acetyltransferase
HWH77_RS02415	COG3829	transcription factor binding
HWH77_RS02415	COG3290	protein histidine kinase activity
HWH77_RS02425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWH77_RS02430	COG2079	MmgE PrpD family protein
HWH77_RS02435	COG0372	Belongs to the citrate synthase family
HWH77_RS02440	COG1960	acyl-CoA dehydrogenase activity
HWH77_RS02445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWH77_RS02450	COG0183	Belongs to the thiolase family
HWH77_RS02455	COG0584	glycerophosphoryl diester phosphodiesterase
HWH77_RS02460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS02485	COG1902	pentaerythritol trinitrate reductase activity
HWH77_RS02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWH77_RS02505	COG0745	RESPONSE REGULATOR receiver
HWH77_RS02510	COG0750	zinc metalloprotease
HWH77_RS02515	COG0497	DNA recombination
HWH77_RS02525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HWH77_RS02535	COG0142	geranyltranstransferase activity
HWH77_RS02545	COG1570	exodeoxyribonuclease VII activity
HWH77_RS02560	COG1302	Protein conserved in bacteria
HWH77_RS02565	COG0439	Biotin carboxylase
HWH77_RS02570	COG0511	ligase activity, forming carbon-carbon bonds
HWH77_RS02610	COG3854	ATPases associated with a variety of cellular activities
HWH77_RS02625	COG0006	proline dipeptidase activity
HWH77_RS02635	COG3872	metal-dependent enzyme
HWH77_RS02645	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWH77_RS02660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWH77_RS02680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWH77_RS02695	COG1396	sequence-specific DNA binding
HWH77_RS02705	COG0681	Belongs to the peptidase S26 family
HWH77_RS02730	COG4940	Competence protein ComGF
HWH77_RS02740	COG4970	Tfp pilus assembly protein FimT
HWH77_RS02745	COG4537	Required for transformation and DNA binding
HWH77_RS02750	COG1459	type II secretion system
HWH77_RS02755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWH77_RS02760	COG0598	Magnesium transport protein CorA
HWH77_RS02765	COG1253	flavin adenine dinucleotide binding
HWH77_RS02770	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS02780	COG1393	Belongs to the ArsC family
HWH77_RS02790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS02800	COG0011	TIGRFAM Protein of
HWH77_RS02810	COG2866	Carboxypeptidase
HWH77_RS02815	COG1940	carbohydrate kinase activity
HWH77_RS02820	COG4483	Protein conserved in bacteria
HWH77_RS02825	COG1757	Na H antiporter
HWH77_RS02835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWH77_RS02850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWH77_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWH77_RS02860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWH77_RS02865	COG0581	inorganic phosphate transmembrane transporter activity
HWH77_RS02870	COG0573	inorganic phosphate transmembrane transporter activity
HWH77_RS02875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWH77_RS02880	COG0768	penicillin binding
HWH77_RS02885	COG0477	Major facilitator Superfamily
HWH77_RS02890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWH77_RS02895	COG2839	Protein conserved in bacteria
HWH77_RS02900	COG5521	maltodextrose utilization protein MalA
HWH77_RS02905	COG1388	LysM domain
HWH77_RS02915	COG4709	membrane
HWH77_RS02920	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HWH77_RS02925	COG0735	belongs to the Fur family
HWH77_RS02930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS02945	COG0513	Belongs to the DEAD box helicase family
HWH77_RS02960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWH77_RS02965	COG2384	SAM-dependent methyltransferase
HWH77_RS02970	COG2010	Cytochrome c
HWH77_RS02975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWH77_RS02980	COG0358	DNA primase activity
HWH77_RS02995	COG0517	IMP dehydrogenase activity
HWH77_RS03000	COG0751	glycine-tRNA ligase activity
HWH77_RS03020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWH77_RS03025	COG0295	cytidine deaminase activity
HWH77_RS03030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HWH77_RS03040	COG1480	7TM receptor with intracellular HD hydrolase
HWH77_RS03045	COG1702	phosphate starvation-inducible protein PhoH
HWH77_RS03050	COG0561	phosphatase activity
HWH77_RS03065	COG4864	UPF0365 protein
HWH77_RS03070	COG1030	water channel activity
HWH77_RS03075	COG1610	YqeY-like protein
HWH77_RS03085	COG1283	sodium-dependent phosphate transmembrane transporter activity
HWH77_RS03090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWH77_RS03095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWH77_RS03125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWH77_RS03140	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS03155	COG1466	dna polymerase III delta subunit
HWH77_RS03170	COG0658	competence protein
HWH77_RS03170	COG2333	competence protein COMEC
HWH77_RS03175	COG2131	deaminase
HWH77_RS03180	COG1596	polysaccharide export
HWH77_RS03180	COG1555	photosystem II stabilization
HWH77_RS03185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWH77_RS03190	COG2226	methyltransferase
HWH77_RS03195	COG0799	negative regulation of ribosome biogenesis
HWH77_RS03200	COG1713	HD superfamily hydrolase involved in NAD metabolism
HWH77_RS03210	COG1534	Rna-binding protein
HWH77_RS03215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWH77_RS03220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWH77_RS03225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HWH77_RS03235	COG2755	lipolytic protein G-D-S-L family
HWH77_RS03245	COG0398	Pfam SNARE associated Golgi protein
HWH77_RS03270	COG2207	Transcriptional regulator
HWH77_RS03270	COG3708	Transcriptional regulator
HWH77_RS03275	COG0563	adenylate kinase activity
HWH77_RS03280	COG2814	Major facilitator Superfamily
HWH77_RS03290	COG0456	acetyltransferase
HWH77_RS03295	COG2318	DinB family
HWH77_RS03305	COG0561	phosphatase activity
HWH77_RS03310	COG0561	phosphatase activity
HWH77_RS03320	COG1482	cell wall glycoprotein biosynthetic process
HWH77_RS03325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWH77_RS03325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWH77_RS03325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS03330	COG3711	transcriptional antiterminator
HWH77_RS03330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS03340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWH77_RS03345	COG0583	DNA-binding transcription factor activity
HWH77_RS03350	COG2814	Major facilitator Superfamily
HWH77_RS03355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWH77_RS03355	COG2124	cytochrome p450
HWH77_RS03360	COG1309	transcriptional regulator
HWH77_RS03365	COG2226	methyltransferase
HWH77_RS03380	COG2116	formate transmembrane transporter activity
HWH77_RS03385	COG5609	conserved protein (DUF2294)
HWH77_RS03390	COG3383	formate dehydrogenase (NAD+) activity
HWH77_RS03395	COG2427	Protein of unknown function (DUF1641)
HWH77_RS03405	COG0626	cystathionine gamma-synthase activity
HWH77_RS03410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWH77_RS03435	COG0768	penicillin binding
HWH77_RS03450	COG0826	peptidase U32
HWH77_RS03455	COG0826	peptidase U32
HWH77_RS03460	COG4122	O-methyltransferase activity
HWH77_RS03465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWH77_RS03480	COG4472	Bacterial protein of unknown function (DUF965)
HWH77_RS03490	COG0628	permease
HWH77_RS03495	COG1126	abc transporter atp-binding protein
HWH77_RS03500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS03505	COG0765	amino acid transport
HWH77_RS03510	COG0765	amino acid transport
HWH77_RS03525	COG3881	PFAM PRC-barrel domain
HWH77_RS03530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWH77_RS03535	COG0457	Tetratricopeptide repeat
HWH77_RS03545	COG1104	cysteine desulfurase activity
HWH77_RS03550	COG1959	2 iron, 2 sulfur cluster binding
HWH77_RS03555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWH77_RS03560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWH77_RS03585	COG4991	sh3 domain protein
HWH77_RS03585	COG3103	Sh3 type 3 domain protein
HWH77_RS03585	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS03595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWH77_RS03605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWH77_RS03605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HWH77_RS03610	COG5416	Lipopolysaccharide assembly protein A domain
HWH77_RS03615	COG0490	domain, Protein
HWH77_RS03620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWH77_RS03620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWH77_RS03630	COG2244	polysaccharide biosynthetic process
HWH77_RS03635	COG2323	membrane
HWH77_RS03645	COG1862	Preprotein translocase
HWH77_RS03690	COG1388	LysM domain
HWH77_RS03700	COG0157	Belongs to the NadC ModD family
HWH77_RS03705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWH77_RS03710	COG1104	cysteine desulfurase activity
HWH77_RS03715	COG1827	regulation of RNA biosynthetic process
HWH77_RS03720	COG0077	Prephenate dehydratase
HWH77_RS03735	COG3290	protein histidine kinase activity
HWH77_RS03740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWH77_RS03745	COG2868	ribosomal protein
HWH77_RS03755	COG1994	Peptidase M50
HWH77_RS03760	COG0739	heme binding
HWH77_RS03765	COG2894	cell division
HWH77_RS03775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWH77_RS03785	COG1077	Cell shape determining protein MreB Mrl
HWH77_RS03805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HWH77_RS03810	COG0285	dihydrofolate synthase activity
HWH77_RS03815	COG0525	valine-tRNA ligase activity
HWH77_RS03825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWH77_RS03830	COG1388	LysM domain
HWH77_RS03840	COG0113	porphobilinogen synthase activity
HWH77_RS03845	COG1587	Uroporphyrinogen-III synthase
HWH77_RS03855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWH77_RS03875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWH77_RS03880	COG1067	ATP-dependent peptidase activity
HWH77_RS03880	COG0470	DNA polymerase III
HWH77_RS03895	COG0457	Tetratricopeptide repeat
HWH77_RS03895	COG1477	protein flavinylation
HWH77_RS03910	COG0473	3-isopropylmalate dehydrogenase activity
HWH77_RS03925	COG0440	acetolactate synthase activity
HWH77_RS03930	COG0028	Belongs to the TPP enzyme family
HWH77_RS03960	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HWH77_RS03980	COG0622	Phosphoesterase
HWH77_RS03985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWH77_RS03995	COG5401	PFAM Sporulation and spore germination
HWH77_RS04005	COG1846	Transcriptional regulator
HWH77_RS04010	COG2197	response regulator
HWH77_RS04015	COG0824	Thioesterase
HWH77_RS04020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWH77_RS04025	COG1053	succinate dehydrogenase
HWH77_RS04030	COG2009	succinate dehydrogenase
HWH77_RS04035	COG1719	4-vinyl reductase, 4VR
HWH77_RS04040	COG0527	aspartate kinase activity
HWH77_RS04050	COG3118	belongs to the thioredoxin family
HWH77_RS04055	COG3534	alpha-L-arabinofuranosidase
HWH77_RS04060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HWH77_RS04065	COG2086	electron transfer activity
HWH77_RS04070	COG1024	Enoyl-CoA hydratase
HWH77_RS04075	COG1309	transcriptional regulator
HWH77_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS04090	COG3766	membrane
HWH77_RS04100	COG1796	DNA polymerase
HWH77_RS04100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWH77_RS04105	COG1286	toxin biosynthetic process
HWH77_RS04120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWH77_RS04120	COG0072	phenylalanine-tRNA ligase activity
HWH77_RS04125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWH77_RS04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWH77_RS04140	COG3835	regulator
HWH77_RS04145	COG0277	FAD linked oxidase domain protein
HWH77_RS04150	COG0247	lactate metabolic process
HWH77_RS04155	COG1966	Carbon starvation protein
HWH77_RS04160	COG3534	alpha-L-arabinofuranosidase
HWH77_RS04165	COG0395	ABC-type sugar transport system, permease component
HWH77_RS04170	COG1175	transmembrane transport
HWH77_RS04175	COG1653	transport
HWH77_RS04185	COG0647	UMP catabolic process
HWH77_RS04190	COG0235	Class ii aldolase
HWH77_RS04195	COG1069	ribulokinase activity
HWH77_RS04200	COG2160	L-arabinose isomerase activity
HWH77_RS04205	COG3507	Belongs to the glycosyl hydrolase 43 family
HWH77_RS04210	COG1363	Peptidase, m42
HWH77_RS04220	COG3326	Membrane
HWH77_RS04225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWH77_RS04235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWH77_RS04240	COG1346	cytolysis
HWH77_RS04245	COG1380	Effector of murein hydrolase LrgA
HWH77_RS04250	COG3279	Response regulator of the LytR AlgR family
HWH77_RS04255	COG3275	phosphorelay sensor kinase activity
HWH77_RS04260	COG1011	Hydrolase
HWH77_RS04275	COG0398	Pfam SNARE associated Golgi protein
HWH77_RS04280	COG1484	DNA-dependent DNA replication
HWH77_RS04285	COG3611	Membrane attachment protein
HWH77_RS04300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWH77_RS04305	COG1733	regulation of RNA biosynthetic process
HWH77_RS04310	COG2814	Major facilitator Superfamily
HWH77_RS04315	COG0656	L-ascorbic acid biosynthetic process
HWH77_RS04320	COG0237	dephospho-CoA kinase activity
HWH77_RS04325	COG1971	Probably functions as a manganese efflux pump
HWH77_RS04330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWH77_RS04335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWH77_RS04335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWH77_RS04340	COG5002	protein histidine kinase activity
HWH77_RS04345	COG0745	RESPONSE REGULATOR receiver
HWH77_RS04355	COG0538	isocitrate dehydrogenase activity
HWH77_RS04360	COG0372	Belongs to the citrate synthase family
HWH77_RS04380	COG0628	permease
HWH77_RS04385	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWH77_RS04390	COG0469	pyruvate kinase activity
HWH77_RS04410	COG0281	malic enzyme
HWH77_RS04415	COG0587	DNA-directed DNA polymerase activity
HWH77_RS04435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HWH77_RS04445	COG4109	DRTGG domain
HWH77_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS04470	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWH77_RS04480	COG0827	DNA restriction-modification system
HWH77_RS04485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HWH77_RS04490	COG3874	Sporulation protein YtfJ
HWH77_RS04500	COG1714	RDD family
HWH77_RS04505	COG0616	signal peptide processing
HWH77_RS04510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWH77_RS04515	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HWH77_RS04520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWH77_RS04535	COG1104	cysteine desulfurase activity
HWH77_RS04540	COG1114	Component of the transport system for branched-chain amino acids
HWH77_RS04550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWH77_RS04555	COG1309	transcriptional regulator
HWH77_RS04560	COG1956	GAF domain-containing protein
HWH77_RS04565	COG2203	Gaf domain
HWH77_RS04565	COG2199	diguanylate cyclase activity
HWH77_RS04575	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS04580	COG4282	regulation of fungal-type cell wall biogenesis
HWH77_RS04610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWH77_RS04610	COG1017	nitric oxide dioxygenase activity
HWH77_RS04635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWH77_RS04640	COG1378	Sugar-specific transcriptional regulator TrmB
HWH77_RS04660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWH77_RS04665	COG0454	-acetyltransferase
HWH77_RS04670	COG0517	IMP dehydrogenase activity
HWH77_RS04675	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWH77_RS04680	COG1360	Flagellar Motor Protein
HWH77_RS04685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWH77_RS04690	COG1609	Transcriptional regulator
HWH77_RS04695	COG1605	Chorismate mutase
HWH77_RS04695	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HWH77_RS04700	COG3118	belongs to the thioredoxin family
HWH77_RS04705	COG4980	gas vesicle protein
HWH77_RS04710	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWH77_RS04720	COG1674	ftsk spoiiie
HWH77_RS04725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWH77_RS04735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS04745	COG1363	Peptidase, m42
HWH77_RS04750	COG5584	Small secreted protein
HWH77_RS04755	COG0281	malic enzyme
HWH77_RS04760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS04775	COG0510	thiamine kinase activity
HWH77_RS04780	COG1597	lipid kinase activity
HWH77_RS04790	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWH77_RS04795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWH77_RS04800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWH77_RS04805	COG2252	PERMEase
HWH77_RS04810	COG4473	ABC transporter
HWH77_RS04815	COG1131	(ABC) transporter
HWH77_RS04820	COG1349	DNA-binding transcription factor activity
HWH77_RS04825	COG1187	pseudouridine synthase activity
HWH77_RS04830	COG2244	polysaccharide biosynthetic process
HWH77_RS04835	COG2081	HI0933 family
HWH77_RS04840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWH77_RS04850	COG1609	Transcriptional regulator
HWH77_RS04855	COG1653	transport
HWH77_RS04860	COG1175	transmembrane transport
HWH77_RS04865	COG0395	ABC-type sugar transport system, permease component
HWH77_RS04870	COG1486	melibiose metabolic process
HWH77_RS04880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWH77_RS04895	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS04895	COG2202	Pas domain
HWH77_RS04900	COG2814	Major facilitator Superfamily
HWH77_RS04905	COG5522	Integral membrane protein (intg_mem_TP0381)
HWH77_RS04910	COG0577	efflux transmembrane transporter activity
HWH77_RS04915	COG1136	(ABC) transporter
HWH77_RS04920	COG2205	protein histidine kinase activity
HWH77_RS04925	COG0745	RESPONSE REGULATOR receiver
HWH77_RS04930	COG0577	efflux transmembrane transporter activity
HWH77_RS04935	COG1136	(ABC) transporter
HWH77_RS04955	COG1131	(ABC) transporter
HWH77_RS04960	COG1725	Transcriptional regulator
HWH77_RS04975	COG0477	Major facilitator Superfamily
HWH77_RS04980	COG1242	4 iron, 4 sulfur cluster binding
HWH77_RS04985	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HWH77_RS04995	COG0584	glycerophosphoryl diester phosphodiesterase
HWH77_RS05005	COG2267	carboxylic ester hydrolase activity
HWH77_RS05010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWH77_RS05015	COG1113	amino acid transport
HWH77_RS05020	COG0367	asparagine synthase
HWH77_RS05040	COG1506	peptidase
HWH77_RS05045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWH77_RS05050	COG1116	anion transmembrane transporter activity
HWH77_RS05055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWH77_RS05060	COG0494	nUDIX hydrolase
HWH77_RS05065	COG4824	toxin secretion phage lysis holin
HWH77_RS05070	COG0783	Belongs to the Dps family
HWH77_RS05095	COG0288	reversible hydration of carbon dioxide
HWH77_RS05105	COG1271	oxidase subunit
HWH77_RS05110	COG1294	oxidase, subunit
HWH77_RS05120	COG4948	Mandelate Racemase Muconate Lactonizing
HWH77_RS05130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HWH77_RS05135	COG0596	Alpha beta hydrolase
HWH77_RS05145	COG1169	isochorismate synthase
HWH77_RS05150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWH77_RS05155	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HWH77_RS05280	COG3859	Proton-coupled thiamine transporter YuaJ
HWH77_RS05285	COG2268	Band 7 protein
HWH77_RS05290	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWH77_RS05295	COG2318	DinB family
HWH77_RS05305	COG1454	alcohol dehydrogenase
HWH77_RS05310	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS05315	COG1510	regulation of RNA biosynthetic process
HWH77_RS05325	COG0569	domain protein
HWH77_RS05330	COG1705	Flagellar rod assembly protein muramidase FlgJ
HWH77_RS05335	COG1017	nitric oxide dioxygenase activity
HWH77_RS05335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWH77_RS05500	COG5484	DNA packaging
HWH77_RS05525	COG1595	DNA-templated transcription, initiation
HWH77_RS05600	COG1484	DNA-dependent DNA replication
HWH77_RS05605	COG3935	DnaD domain protein
HWH77_RS05655	COG3620	sequence-specific DNA binding
HWH77_RS05665	COG2856	Zn peptidase
HWH77_RS05670	COG0582	viral genome integration into host DNA
HWH77_RS05685	COG0628	permease
HWH77_RS05690	COG0673	inositol 2-dehydrogenase activity
HWH77_RS05695	COG0693	protein deglycase activity
HWH77_RS05700	COG0840	transmembrane signaling receptor activity
HWH77_RS05705	COG0840	transmembrane signaling receptor activity
HWH77_RS05710	COG0840	transmembrane signaling receptor activity
HWH77_RS05715	COG0840	transmembrane signaling receptor activity
HWH77_RS05730	COG2070	2-Nitropropane dioxygenase
HWH77_RS05735	COG0432	Pfam Uncharacterised protein family UPF0047
HWH77_RS05740	COG0366	Alpha amylase catalytic
HWH77_RS05745	COG1253	flavin adenine dinucleotide binding
HWH77_RS05750	COG2738	Putative neutral zinc metallopeptidase
HWH77_RS05765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWH77_RS05790	COG1335	isochorismatase
HWH77_RS05795	COG1979	alcohol dehydrogenase
HWH77_RS05800	COG1979	alcohol dehydrogenase
HWH77_RS05805	COG2155	Conserved Protein
HWH77_RS05810	COG1098	S1 RNA binding domain
HWH77_RS05815	COG0436	Aminotransferase
HWH77_RS05820	COG1522	sequence-specific DNA binding
HWH77_RS05825	COG2267	carboxylic ester hydrolase activity
HWH77_RS05835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HWH77_RS05840	COG2205	protein histidine kinase activity
HWH77_RS05850	COG5018	Exonuclease
HWH77_RS05855	COG2814	Major facilitator Superfamily
HWH77_RS05860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWH77_RS05865	COG3011	Protein conserved in bacteria
HWH77_RS05875	COG3290	protein histidine kinase activity
HWH77_RS05880	COG4565	transcriptional regulatory protein
HWH77_RS05885	COG1744	ABC transporter substrate-binding protein PnrA-like
HWH77_RS05890	COG3845	ABC transporter
HWH77_RS05895	COG4603	Belongs to the binding-protein-dependent transport system permease family
HWH77_RS05900	COG1079	Belongs to the binding-protein-dependent transport system permease family
HWH77_RS05910	COG2111	Na H antiporter
HWH77_RS05910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWH77_RS05915	COG2111	Na H antiporter
HWH77_RS05920	COG1006	Multisubunit Na H antiporter MnhC subunit
HWH77_RS05925	COG0651	ATP synthesis coupled electron transport
HWH77_RS05930	COG1863	multisubunit Na H antiporter MnhE subunit
HWH77_RS05935	COG2212	antiporter activity
HWH77_RS05940	COG1320	monovalent cation:proton antiporter activity
HWH77_RS05945	COG2050	protein possibly involved in aromatic compounds catabolism
HWH77_RS05950	COG2197	response regulator
HWH77_RS05975	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HWH77_RS05980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HWH77_RS05985	COG1335	isochorismatase
HWH77_RS05990	COG5506	Protein of unknown function (DUF1694)
HWH77_RS06005	COG0628	permease
HWH77_RS06015	COG1418	mRNA catabolic process
HWH77_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS06030	COG1511	domain protein
HWH77_RS06035	COG0433	COG0433 Predicted ATPase
HWH77_RS06035	COG1674	ftsk spoiiie
HWH77_RS06040	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWH77_RS06045	COG5417	Belongs to the EsaB family
HWH77_RS06050	COG4842	Belongs to the WXG100 family
HWH77_RS06055	COG2508	Transcriptional regulator
HWH77_RS06055	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWH77_RS06060	COG0686	Belongs to the AlaDH PNT family
HWH77_RS06065	COG5634	Uncharacterized conserved protein (DUF2278)
HWH77_RS06070	COG3251	PFAM MbtH domain protein
HWH77_RS06075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS06080	COG1535	isochorismatase
HWH77_RS06080	COG3433	isochorismatase activity
HWH77_RS06085	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWH77_RS06090	COG1169	isochorismate synthase
HWH77_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS06100	COG2819	hydrolase of the alpha beta superfamily
HWH77_RS06105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWH77_RS06110	COG1268	BioY protein
HWH77_RS06115	COG2056	Na+-H+ antiporter family
HWH77_RS06125	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HWH77_RS06130	COG3584	3D domain protein
HWH77_RS06145	COG1252	NADH dehydrogenase
HWH77_RS06175	COG1131	(ABC) transporter
HWH77_RS06200	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HWH77_RS06205	COG0316	Belongs to the HesB IscA family
HWH77_RS06215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWH77_RS06225	COG1252	NADH dehydrogenase
HWH77_RS06230	COG4837	Protein of unknown function (DUF1462)
HWH77_RS06235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HWH77_RS06240	COG4946	Tricorn protease homolog
HWH77_RS06240	COG1506	peptidase
HWH77_RS06240	COG0823	Involved in the tonB-independent uptake of proteins
HWH77_RS06250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWH77_RS06255	COG0460	homoserine dehydrogenase
HWH77_RS06260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWH77_RS06265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWH77_RS06270	COG0647	UMP catabolic process
HWH77_RS06275	COG2445	Protein of unknown function DUF86
HWH77_RS06280	COG4470	Protein conserved in bacteria
HWH77_RS06290	COG0739	heme binding
HWH77_RS06300	COG0737	Belongs to the 5'-nucleotidase family
HWH77_RS06305	COG0730	response to heat
HWH77_RS06310	COG1801	Protein of unknown function DUF72
HWH77_RS06325	COG2508	Transcriptional regulator
HWH77_RS06340	COG2814	Major facilitator Superfamily
HWH77_RS06345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWH77_RS06350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWH77_RS06355	COG2356	endonuclease I
HWH77_RS06360	COG3842	ATPase activity
HWH77_RS06365	COG2188	Transcriptional regulator
HWH77_RS06370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWH77_RS06375	COG0395	ABC-type sugar transport system, permease component
HWH77_RS06380	COG1175	transmembrane transport
HWH77_RS06385	COG1653	transport
HWH77_RS06390	COG2222	sugar isomerase
HWH77_RS06400	COG0322	excinuclease ABC activity
HWH77_RS06405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWH77_RS06410	COG2226	methyltransferase
HWH77_RS06420	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS06425	COG0719	Fe-S assembly protein
HWH77_RS06430	COG0822	iron-sulfur transferase activity
HWH77_RS06435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWH77_RS06440	COG0719	Fe-S assembly protein
HWH77_RS06445	COG0396	ATPase activity
HWH77_RS06455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWH77_RS06460	COG1464	Belongs to the NlpA lipoprotein family
HWH77_RS06465	COG2011	ABC-type metal ion transport system permease component
HWH77_RS06470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWH77_RS06480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS06485	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWH77_RS06500	COG1393	Belongs to the ArsC family
HWH77_RS06505	COG1960	acyl-CoA dehydrogenase activity
HWH77_RS06510	COG0183	Belongs to the thiolase family
HWH77_RS06515	COG1024	Enoyl-CoA hydratase
HWH77_RS06515	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWH77_RS06535	COG5577	PFAM Coat F domain
HWH77_RS06540	COG1846	Transcriptional regulator
HWH77_RS06545	COG0477	Major facilitator Superfamily
HWH77_RS06550	COG0583	DNA-binding transcription factor activity
HWH77_RS06570	COG1120	ATPase activity
HWH77_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS06590	COG0783	Belongs to the Dps family
HWH77_RS06595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWH77_RS06600	COG0745	RESPONSE REGULATOR receiver
HWH77_RS06605	COG2205	protein histidine kinase activity
HWH77_RS06605	COG2770	Histidine kinase
HWH77_RS06615	COG1309	transcriptional regulator
HWH77_RS06620	COG0114	fumarate hydratase activity
HWH77_RS06630	COG0697	spore germination
HWH77_RS06635	COG0814	amino acid
HWH77_RS06645	COG2197	response regulator
HWH77_RS06650	COG4585	Histidine kinase
HWH77_RS06655	COG4758	membrane
HWH77_RS06660	COG3595	metallopeptidase activity
HWH77_RS06665	COG1842	Phage shock protein A
HWH77_RS06670	COG4758	membrane
HWH77_RS06675	COG2814	Major facilitator Superfamily
HWH77_RS06680	COG2096	Adenosyltransferase
HWH77_RS06685	COG1120	ATPase activity
HWH77_RS06690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS06695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWH77_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS06705	COG3386	PFAM SMP-30 Gluconolaconase
HWH77_RS06710	COG2205	protein histidine kinase activity
HWH77_RS06715	COG0745	RESPONSE REGULATOR receiver
HWH77_RS06725	COG1191	sigma factor activity
HWH77_RS06735	COG2140	Oxalate decarboxylase
HWH77_RS06745	COG1120	ATPase activity
HWH77_RS06750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS06755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS06760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWH77_RS06765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWH77_RS06770	COG0531	amino acid
HWH77_RS06780	COG1988	membrane-bound metal-dependent
HWH77_RS06795	COG1910	domain protein
HWH77_RS06800	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWH77_RS06805	COG4149	molybdate abc transporter
HWH77_RS06810	COG2197	response regulator
HWH77_RS06815	COG3850	Histidine kinase
HWH77_RS06820	COG1131	(ABC) transporter
HWH77_RS06830	COG0842	Transport permease protein
HWH77_RS06835	COG0656	L-ascorbic acid biosynthetic process
HWH77_RS06855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWH77_RS06860	COG3973	AAA domain
HWH77_RS06865	COG2860	membrane
HWH77_RS06875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWH77_RS06880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWH77_RS06885	COG2217	Heavy metal translocating P-type atpase
HWH77_RS06890	COG2217	Heavy metal translocating P-type atpase
HWH77_RS06895	COG2608	mercury ion transmembrane transporter activity
HWH77_RS06900	COG1937	Protein conserved in bacteria
HWH77_RS06905	COG0673	inositol 2-dehydrogenase activity
HWH77_RS06920	COG2814	Major facilitator Superfamily
HWH77_RS06935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS06940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWH77_RS06945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS06950	COG1126	abc transporter atp-binding protein
HWH77_RS06955	COG0765	amino acid transport
HWH77_RS06960	COG0765	amino acid transport
HWH77_RS06965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS06970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS06975	COG0454	-acetyltransferase
HWH77_RS06980	COG0583	DNA-binding transcription factor activity
HWH77_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS06990	COG2732	(Barnase) inhibitor
HWH77_RS07005	COG0557	exoribonuclease II activity
HWH77_RS07010	COG1647	Serine aminopeptidase, S33
HWH77_RS07015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWH77_RS07020	COG1476	TRANSCRIPTIONal
HWH77_RS07025	COG1396	sequence-specific DNA binding
HWH77_RS07030	COG1396	sequence-specific DNA binding
HWH77_RS07035	COG1733	regulation of RNA biosynthetic process
HWH77_RS07060	COG1131	(ABC) transporter
HWH77_RS07065	COG1174	glycine betaine transport
HWH77_RS07070	COG1732	Glycine betaine
HWH77_RS07075	COG1174	glycine betaine transport
HWH77_RS07080	COG1125	glycine betaine transport
HWH77_RS07080	COG0517	IMP dehydrogenase activity
HWH77_RS07085	COG1510	regulation of RNA biosynthetic process
HWH77_RS07090	COG1174	glycine betaine transport
HWH77_RS07095	COG1732	Glycine betaine
HWH77_RS07100	COG1174	glycine betaine transport
HWH77_RS07105	COG0517	IMP dehydrogenase activity
HWH77_RS07105	COG1125	glycine betaine transport
HWH77_RS07110	COG1510	regulation of RNA biosynthetic process
HWH77_RS07115	COG2095	MarC family integral membrane protein
HWH77_RS07120	COG3064	Membrane
HWH77_RS07125	COG4640	response to antibiotic
HWH77_RS07130	COG0456	acetyltransferase
HWH77_RS07145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWH77_RS07160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWH77_RS07165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS07170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWH77_RS07180	COG2234	aminopeptidase activity
HWH77_RS07200	COG0126	phosphoglycerate kinase activity
HWH77_RS07205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWH77_RS07210	COG2390	Transcriptional regulator
HWH77_RS07215	COG2814	Major facilitator Superfamily
HWH77_RS07220	COG1609	Transcriptional regulator
HWH77_RS07225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS07235	COG0583	DNA-binding transcription factor activity
HWH77_RS07240	COG0697	spore germination
HWH77_RS07245	COG1113	amino acid transport
HWH77_RS07250	COG1737	Transcriptional regulator
HWH77_RS07255	COG1070	Carbohydrate kinase
HWH77_RS07280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWH77_RS07285	COG2186	Transcriptional regulator
HWH77_RS07290	COG1620	l-lactate permease
HWH77_RS07295	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HWH77_RS07305	COG5039	Polysaccharide pyruvyl transferase
HWH77_RS07310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWH77_RS07315	COG0110	maltose O-acetyltransferase activity
HWH77_RS07320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWH77_RS07325	COG2244	polysaccharide biosynthetic process
HWH77_RS07330	COG1216	Glycosyl transferase, family 2
HWH77_RS07335	COG5039	Polysaccharide pyruvyl transferase
HWH77_RS07340	COG1216	Glycosyl transferase, family 2
HWH77_RS07350	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS07355	COG1215	transferase activity, transferring glycosyl groups
HWH77_RS07360	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS07365	COG1086	Polysaccharide biosynthesis protein
HWH77_RS07370	COG0489	protein tyrosine kinase activity
HWH77_RS07375	COG3944	biosynthesis protein
HWH77_RS07380	COG1396	sequence-specific DNA binding
HWH77_RS07385	COG2272	Belongs to the type-B carboxylesterase lipase family
HWH77_RS07395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWH77_RS07400	COG2364	Membrane
HWH77_RS07405	COG0456	acetyltransferase
HWH77_RS07410	COG3479	Phenolic acid decarboxylase
HWH77_RS07445	COG2223	nitrite transmembrane transporter activity
HWH77_RS07450	COG1609	Transcriptional regulator
HWH77_RS07460	COG0583	DNA-binding transcription factor activity
HWH77_RS07465	COG2828	Protein conserved in bacteria
HWH77_RS07470	COG0477	Major facilitator Superfamily
HWH77_RS07470	COG2814	Major facilitator Superfamily
HWH77_RS07475	COG1611	Belongs to the LOG family
HWH77_RS07480	COG1694	Mazg nucleotide pyrophosphohydrolase
HWH77_RS07485	COG0659	secondary active sulfate transmembrane transporter activity
HWH77_RS07490	COG0288	reversible hydration of carbon dioxide
HWH77_RS07495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWH77_RS07500	COG4290	ribonuclease
HWH77_RS07505	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HWH77_RS07510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS07520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HWH77_RS07530	COG1051	belongs to the nudix hydrolase family
HWH77_RS07535	COG0492	ferredoxin-NADP+ reductase activity
HWH77_RS07540	COG3883	PFAM NLP P60 protein
HWH77_RS07540	COG0791	NLP P60 protein
HWH77_RS07545	COG0457	Tetratricopeptide repeat
HWH77_RS07550	COG5002	protein histidine kinase activity
HWH77_RS07555	COG0745	RESPONSE REGULATOR receiver
HWH77_RS07565	COG1132	(ABC) transporter
HWH77_RS07570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWH77_RS07570	COG0140	phosphoribosyl-ATP diphosphatase activity
HWH77_RS07595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWH77_RS07610	COG4990	cell redox homeostasis
HWH77_RS07615	COG0110	maltose O-acetyltransferase activity
HWH77_RS07635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HWH77_RS07645	COG2188	Transcriptional regulator
HWH77_RS07650	COG1309	transcriptional regulator
HWH77_RS07655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWH77_RS07660	COG1950	PFAM Membrane protein of
HWH77_RS07665	COG1983	PspC domain protein
HWH77_RS07670	COG3595	metallopeptidase activity
HWH77_RS07685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWH77_RS07695	COG4897	Protein conserved in bacteria
HWH77_RS07700	COG0574	Belongs to the PEP-utilizing enzyme family
HWH77_RS07700	COG3848	Pyruvate phosphate dikinase
HWH77_RS07705	COG1309	transcriptional regulator
HWH77_RS07710	COG2814	Major facilitator Superfamily
HWH77_RS07740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWH77_RS07750	COG0793	Belongs to the peptidase S41A family
HWH77_RS07750	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS07755	COG3420	alginic acid biosynthetic process
HWH77_RS07760	COG2177	Part of the ABC transporter FtsEX involved in
HWH77_RS07765	COG2884	Cell division ATP-binding protein ftsE
HWH77_RS07770	COG2010	Cytochrome c
HWH77_RS07775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS07790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HWH77_RS07805	COG1516	flagellar protein fliS
HWH77_RS07810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HWH77_RS07815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWH77_RS07835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWH77_RS07840	COG1256	bacterial-type flagellum assembly
HWH77_RS07840	COG4786	Flagellar basal body rod
HWH77_RS07845	COG3418	PFAM FlgN family protein
HWH77_RS07850	COG2747	anti-sigma28 factor FlgM
HWH77_RS07860	COG1040	competence protein
HWH77_RS07870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HWH77_RS07875	COG1307	EDD domain protein, DegV family
HWH77_RS07880	COG2197	response regulator
HWH77_RS07885	COG4585	Histidine kinase
HWH77_RS07890	COG1739	Uncharacterized protein family UPF0029
HWH77_RS07895	COG1316	TRANSCRIPTIONal
HWH77_RS07900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWH77_RS07905	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS07910	COG1215	transferase activity, transferring glycosyl groups
HWH77_RS07915	COG3206	protein involved in exopolysaccharide biosynthesis
HWH77_RS07920	COG3307	-O-antigen
HWH77_RS07925	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWH77_RS07930	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS07930	COG0297	glycogen (starch) synthase activity
HWH77_RS07935	COG2244	polysaccharide biosynthetic process
HWH77_RS07945	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS07945	COG2247	cell wall binding repeat
HWH77_RS07950	COG2385	sporulation resulting in formation of a cellular spore
HWH77_RS07950	COG2247	cell wall binding repeat
HWH77_RS07960	COG1316	TRANSCRIPTIONal
HWH77_RS07965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWH77_RS07970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWH77_RS07975	COG1134	teichoic acid transport
HWH77_RS07980	COG1682	transport, permease protein
HWH77_RS07985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWH77_RS07995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HWH77_RS08000	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HWH77_RS08005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWH77_RS08010	COG4193	domain, Protein
HWH77_RS08015	COG1482	cell wall glycoprotein biosynthetic process
HWH77_RS08020	COG0697	spore germination
HWH77_RS08025	COG0814	amino acid
HWH77_RS08035	COG1215	transferase activity, transferring glycosyl groups
HWH77_RS08040	COG2814	Major facilitator Superfamily
HWH77_RS08045	COG1316	TRANSCRIPTIONal
HWH77_RS08050	COG0561	phosphatase activity
HWH77_RS08055	COG2433	Pfam Transposase IS66
HWH77_RS08060	COG0791	NLP P60 protein
HWH77_RS08070	COG2843	Capsule synthesis protein
HWH77_RS08080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWH77_RS08085	COG0697	spore germination
HWH77_RS08090	COG0814	amino acid
HWH77_RS08100	COG1609	Transcriptional regulator
HWH77_RS08105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWH77_RS08115	COG1129	ABC transporter
HWH77_RS08120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWH77_RS08125	COG1879	ABC-type sugar transport system periplasmic component
HWH77_RS08130	COG3103	Sh3 type 3 domain protein
HWH77_RS08135	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWH77_RS08140	COG3527	Alpha-acetolactate decarboxylase
HWH77_RS08145	COG0028	Belongs to the TPP enzyme family
HWH77_RS08150	COG0583	DNA-binding transcription factor activity
HWH77_RS08155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWH77_RS08170	COG5337	Spore coat protein CotH
HWH77_RS08180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWH77_RS08190	COG0405	Gamma-glutamyltransferase
HWH77_RS08195	COG1522	sequence-specific DNA binding
HWH77_RS08200	COG2059	Chromate
HWH77_RS08205	COG2059	Chromate
HWH77_RS08215	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWH77_RS08220	COG0583	DNA-binding transcription factor activity
HWH77_RS08245	COG5444	nuclease activity
HWH77_RS08270	COG5444	nuclease activity
HWH77_RS08285	COG3878	Protein conserved in bacteria
HWH77_RS08290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWH77_RS08295	COG4464	protein tyrosine phosphatase activity
HWH77_RS08300	COG0489	protein tyrosine kinase activity
HWH77_RS08305	COG3944	biosynthesis protein
HWH77_RS08315	COG4715	Zinc finger, swim domain protein
HWH77_RS08320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWH77_RS08325	COG0561	phosphatase activity
HWH77_RS08330	COG1349	DNA-binding transcription factor activity
HWH77_RS08335	COG0629	single-stranded DNA binding
HWH77_RS08360	COG0457	Tetratricopeptide repeat
HWH77_RS08365	COG4786	Flagellar basal body rod
HWH77_RS08370	COG4786	Flagellar basal body rod
HWH77_RS08375	COG1077	Cell shape determining protein MreB Mrl
HWH77_RS08380	COG1609	Transcriptional regulator
HWH77_RS08385	COG1846	Transcriptional regulator
HWH77_RS08390	COG2814	Major facilitator Superfamily
HWH77_RS08395	COG1953	Uracil, thiamine, allantoin
HWH77_RS08400	COG0477	Major facilitator Superfamily
HWH77_RS08405	COG1335	isochorismatase
HWH77_RS08410	COG0004	ammonium transporteR
HWH77_RS08415	COG0347	Belongs to the P(II) protein family
HWH77_RS08420	COG0772	Belongs to the SEDS family
HWH77_RS08425	COG0671	phosphoesterase, PA-phosphatase related
HWH77_RS08435	COG0739	heme binding
HWH77_RS08440	COG1247	-acetyltransferase
HWH77_RS08455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWH77_RS08465	COG0726	polysaccharide deacetylase
HWH77_RS08475	COG1959	2 iron, 2 sulfur cluster binding
HWH77_RS08490	COG0831	urea catabolic process
HWH77_RS08495	COG3237	CsbD-like
HWH77_RS08500	COG1994	Peptidase M50
HWH77_RS08505	COG0457	Tetratricopeptide repeat
HWH77_RS08515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWH77_RS08525	COG2304	oxidoreductase activity
HWH77_RS08530	COG2304	oxidoreductase activity
HWH77_RS08535	COG2385	sporulation resulting in formation of a cellular spore
HWH77_RS08540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWH77_RS08550	COG4836	Membrane
HWH77_RS08620	COG0698	ribose 5-phosphate isomerase
HWH77_RS08625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWH77_RS08635	COG0009	L-threonylcarbamoyladenylate synthase
HWH77_RS08640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWH77_RS08660	COG2890	protein-(glutamine-N5) methyltransferase activity
HWH77_RS08665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWH77_RS08670	COG0346	lactoylglutathione lyase activity
HWH77_RS08675	COG0789	Transcriptional regulator
HWH77_RS08680	COG0679	Auxin Efflux Carrier
HWH77_RS08685	COG0281	malic enzyme
HWH77_RS08700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HWH77_RS08705	COG1494	fructose-1,6-bisphosphatase
HWH77_RS08710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWH77_RS08720	COG0191	fructose-bisphosphate aldolase activity
HWH77_RS08725	COG2204	response regulator
HWH77_RS08730	COG4821	SIS domain
HWH77_RS08745	COG0247	lactate metabolic process
HWH77_RS08745	COG2181	nitrate reductase activity
HWH77_RS08750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWH77_RS08765	COG1132	(ABC) transporter
HWH77_RS08770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWH77_RS08780	COG2181	nitrate reductase activity
HWH77_RS08785	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HWH77_RS08790	COG1140	nitrate reductase beta subunit
HWH77_RS08795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HWH77_RS08800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWH77_RS08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWH77_RS08815	COG2223	nitrite transmembrane transporter activity
HWH77_RS08825	COG4506	Protein conserved in bacteria
HWH77_RS08830	COG0457	Tetratricopeptide repeat
HWH77_RS08865	COG0010	Belongs to the arginase family
HWH77_RS08870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWH77_RS08875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWH77_RS08890	COG1994	Peptidase M50
HWH77_RS08895	COG1942	4-Oxalocrotonate Tautomerase
HWH77_RS08900	COG1846	Transcriptional regulator
HWH77_RS08905	COG0531	amino acid
HWH77_RS08910	COG3465	dGTPase activity
HWH77_RS08915	COG1078	dGTPase activity
HWH77_RS08930	COG1695	Transcriptional regulator
HWH77_RS08940	COG1131	(ABC) transporter
HWH77_RS08945	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWH77_RS08975	COG0583	DNA-binding transcription factor activity
HWH77_RS08980	COG2855	membrane
HWH77_RS08985	COG0280	phosphate acetyltransferase
HWH77_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS09000	COG0436	Aminotransferase
HWH77_RS09030	COG2814	Major facilitator Superfamily
HWH77_RS09035	COG2814	Major facilitator Superfamily
HWH77_RS09040	COG0833	amino acid
HWH77_RS09045	COG4187	Peptidase family M20/M25/M40
HWH77_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS09055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWH77_RS09065	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HWH77_RS09070	COG1091	dTDP-4-dehydrorhamnose reductase activity
HWH77_RS09075	COG1088	dTDP-glucose 4,6-dehydratase activity
HWH77_RS09080	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HWH77_RS09085	COG3980	spore coat polysaccharide biosynthesis protein
HWH77_RS09090	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HWH77_RS09095	COG2089	acid synthase
HWH77_RS09100	COG0456	acetyltransferase
HWH77_RS09105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWH77_RS09110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWH77_RS09115	COG0463	Glycosyl transferase, family 2
HWH77_RS09125	COG2363	Small membrane protein
HWH77_RS09130	COG2233	PERMEase
HWH77_RS09145	COG1216	Glycosyl transferase, family 2
HWH77_RS09160	COG1695	Transcriptional regulator
HWH77_RS09165	COG0351	phosphomethylpyrimidine kinase
HWH77_RS09175	COG1621	beta-fructofuranosidase activity
HWH77_RS09180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS09180	COG1263	PTS System
HWH77_RS09185	COG3711	transcriptional antiterminator
HWH77_RS09195	COG1404	Belongs to the peptidase S8 family
HWH77_RS09200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS09205	COG0778	Nitroreductase
HWH77_RS09210	COG0772	Belongs to the SEDS family
HWH77_RS09215	COG0454	-acetyltransferase
HWH77_RS09235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWH77_RS09240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWH77_RS09245	COG2261	transglycosylase associated protein
HWH77_RS09250	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HWH77_RS09260	COG2246	polysaccharide biosynthetic process
HWH77_RS09265	COG1309	transcriptional regulator
HWH77_RS09285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWH77_RS09290	COG2837	iron assimilation
HWH77_RS09295	COG2822	iron ion transport
HWH77_RS09315	COG0583	DNA-binding transcription factor activity
HWH77_RS09325	COG1346	cytolysis
HWH77_RS09330	COG4895	conserved protein (DUF2196)
HWH77_RS09335	COG0789	Transcriptional regulator
HWH77_RS09340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWH77_RS09345	COG0346	lactoylglutathione lyase activity
HWH77_RS09350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS09355	COG1404	Belongs to the peptidase S8 family
HWH77_RS09360	COG1442	glycosyl transferase family 8
HWH77_RS09365	COG2357	RelA SpoT domain protein
HWH77_RS09370	COG1575	Belongs to the MenA family. Type 1 subfamily
HWH77_RS09385	COG1696	Membrane protein involved in D-alanine export
HWH77_RS09395	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HWH77_RS09400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS09405	COG1486	melibiose metabolic process
HWH77_RS09410	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWH77_RS09415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS09420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS09425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS09425	COG3711	transcriptional antiterminator
HWH77_RS09435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS09440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS09450	COG0640	Transcriptional regulator
HWH77_RS09455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWH77_RS09460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS09465	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWH77_RS09470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS09475	COG2723	6-phospho-beta-galactosidase activity
HWH77_RS09480	COG1940	carbohydrate kinase activity
HWH77_RS09485	COG1482	cell wall glycoprotein biosynthetic process
HWH77_RS09495	COG0753	catalase activity
HWH77_RS09500	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HWH77_RS09505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWH77_RS09510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWH77_RS09515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HWH77_RS09520	COG4988	ABC transporter
HWH77_RS09525	COG1294	oxidase, subunit
HWH77_RS09530	COG1271	oxidase subunit
HWH77_RS09535	COG3493	citrate carrier protein
HWH77_RS09540	COG0726	polysaccharide deacetylase
HWH77_RS09545	COG3842	ATPase activity
HWH77_RS09550	COG2508	Transcriptional regulator
HWH77_RS09555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS09565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWH77_RS09580	COG4894	glucomannan catabolic process
HWH77_RS09585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWH77_RS09590	COG0500	methyltransferase
HWH77_RS09595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWH77_RS09615	COG0753	catalase activity
HWH77_RS09615	COG0693	protein deglycase activity
HWH77_RS09620	COG2851	Citrate transporter
HWH77_RS09625	COG2273	Hydrolase Family 16
HWH77_RS09635	COG2270	Major facilitator Superfamily
HWH77_RS09640	COG0513	Belongs to the DEAD box helicase family
HWH77_RS09710	COG0697	spore germination
HWH77_RS09715	COG0589	response to stress
HWH77_RS09725	COG0494	nUDIX hydrolase
HWH77_RS09730	COG3507	Belongs to the glycosyl hydrolase 43 family
HWH77_RS09755	COG0010	Belongs to the arginase family
HWH77_RS09760	COG0833	amino acid
HWH77_RS09765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HWH77_RS09770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWH77_RS09780	COG2390	Transcriptional regulator
HWH77_RS09785	COG0561	phosphatase activity
HWH77_RS09815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWH77_RS09820	COG5294	Protein conserved in bacteria
HWH77_RS09825	COG0577	efflux transmembrane transporter activity
HWH77_RS09830	COG1136	(ABC) transporter
HWH77_RS09835	COG2205	protein histidine kinase activity
HWH77_RS09840	COG0745	RESPONSE REGULATOR receiver
HWH77_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
HWH77_RS09865	COG2814	Major facilitator Superfamily
HWH77_RS09895	COG1349	DNA-binding transcription factor activity
HWH77_RS09900	COG0667	Aldo Keto reductase
HWH77_RS09905	COG2814	Major facilitator Superfamily
HWH77_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS09920	COG2197	response regulator
HWH77_RS09925	COG4585	Histidine kinase
HWH77_RS09930	COG3239	Fatty acid desaturase
HWH77_RS09935	COG1309	transcriptional regulator
HWH77_RS09940	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS09945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWH77_RS09955	COG0640	Transcriptional regulator
HWH77_RS09960	COG2814	Major facilitator Superfamily
HWH77_RS09965	COG1714	RDD family
HWH77_RS09975	COG0450	alkyl hydroperoxide reductase
HWH77_RS09980	COG3634	alkyl hydroperoxide reductase activity
HWH77_RS09985	COG1113	amino acid transport
HWH77_RS09995	COG2080	2 iron, 2 sulfur cluster binding
HWH77_RS10010	COG2068	MobA-Related Protein
HWH77_RS10015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HWH77_RS10065	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HWH77_RS10070	COG0667	Aldo Keto reductase
HWH77_RS10075	COG0456	acetyltransferase
HWH77_RS10080	COG0457	Tetratricopeptide repeat
HWH77_RS10085	COG0010	Belongs to the arginase family
HWH77_RS10090	COG0833	amino acid
HWH77_RS10095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWH77_RS10100	COG5658	integral membrane protein
HWH77_RS10105	COG0640	Transcriptional regulator
HWH77_RS10110	COG3829	transcription factor binding
HWH77_RS10120	COG0488	(ABC) transporter
HWH77_RS10135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWH77_RS10140	COG5002	protein histidine kinase activity
HWH77_RS10150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWH77_RS10155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HWH77_RS10160	COG4853	Protein conserved in bacteria
HWH77_RS10165	COG4863	YycH protein
HWH77_RS10170	COG5002	protein histidine kinase activity
HWH77_RS10175	COG0745	RESPONSE REGULATOR receiver
HWH77_RS10205	COG0346	lactoylglutathione lyase activity
HWH77_RS10210	COG0305	Participates in initiation and elongation during chromosome replication
HWH77_RS10225	COG3093	addiction module antidote protein HigA
HWH77_RS10230	COG0297	glycogen (starch) synthase activity
HWH77_RS10240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HWH77_RS10245	COG0438	transferase activity, transferring glycosyl groups
HWH77_RS10265	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HWH77_RS10280	COG5577	PFAM Coat F domain
HWH77_RS10285	COG1733	regulation of RNA biosynthetic process
HWH77_RS10295	COG0697	spore germination
HWH77_RS10300	COG1621	beta-fructofuranosidase activity
HWH77_RS10305	COG1621	beta-fructofuranosidase activity
HWH77_RS10310	COG1802	Transcriptional regulator
HWH77_RS10315	COG2318	DinB family
HWH77_RS10320	COG2211	Major facilitator Superfamily
HWH77_RS10330	COG0778	Nitroreductase
HWH77_RS10335	COG1846	Transcriptional regulator
HWH77_RS10340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS10345	COG1846	Transcriptional regulator
HWH77_RS10370	COG0583	DNA-binding transcription factor activity
HWH77_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWH77_RS10385	COG0697	spore germination
HWH77_RS10395	COG1959	2 iron, 2 sulfur cluster binding
HWH77_RS10400	COG1396	sequence-specific DNA binding
HWH77_RS10410	COG1331	Highly conserved protein containing a thioredoxin domain
HWH77_RS10415	COG1266	CAAX protease self-immunity
HWH77_RS10420	COG0477	Major facilitator Superfamily
HWH77_RS10420	COG2814	Major facilitator Superfamily
HWH77_RS10425	COG0346	lactoylglutathione lyase activity
HWH77_RS10430	COG1609	Transcriptional regulator
HWH77_RS10435	COG0708	Exodeoxyribonuclease III
HWH77_RS10440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWH77_RS10445	COG2169	Transcriptional regulator
HWH77_RS10455	COG0629	single-stranded DNA binding
HWH77_RS10465	COG0012	GTP binding
HWH77_RS10470	COG0243	molybdopterin cofactor binding
HWH77_RS10475	COG4481	Protein conserved in bacteria
HWH77_RS10480	COG3949	Membrane
HWH77_RS10495	COG1475	DNA binding
HWH77_RS10500	COG1192	Involved in chromosome partitioning
HWH77_RS10525	COG1847	R3H domain protein
HWH77_RS10530	COG0706	membrane insertase activity
HWH77_RS10550	COG0592	DNA-directed DNA polymerase activity
HWH77_RS10555	COG2501	S4 domain
HWH77_RS10570	COG0187	DNA topoisomerase II activity
HWH77_RS10575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWH77_RS10610	COG0516	GMP reductase activity
HWH77_RS10610	COG0517	IMP dehydrogenase activity
HWH77_RS10615	COG1686	Belongs to the peptidase S11 family
HWH77_RS10635	COG1929	Belongs to the glycerate kinase type-1 family
HWH77_RS10645	COG1428	Deoxynucleoside kinase
HWH77_RS10650	COG1428	Deoxynucleoside kinase
HWH77_RS10655	COG1388	LysM domain
HWH77_RS10655	COG3858	chitin binding
HWH77_RS10660	COG1335	isochorismatase
HWH77_RS10665	COG0590	tRNA wobble adenosine to inosine editing
HWH77_RS10675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWH77_RS10680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWH77_RS10730	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HWH77_RS10735	COG3853	Toxic anion resistance protein (TelA)
HWH77_RS10740	COG1982	Orn Lys Arg decarboxylase major
HWH77_RS10750	COG3870	Protein conserved in bacteria
HWH77_RS10755	COG1728	Protein conserved in bacteria
HWH77_RS10760	COG0470	DNA polymerase III
HWH77_RS10765	COG1774	PSP1 C-terminal conserved region
HWH77_RS10775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HWH77_RS10785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HWH77_RS10790	COG2002	toxin-antitoxin pair type II binding
HWH77_RS10795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWH77_RS10795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWH77_RS10800	COG0084	hydrolase, TatD family'
HWH77_RS10805	COG3583	domain protein
HWH77_RS10805	COG3584	3D domain protein
HWH77_RS10810	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWH77_RS10815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWH77_RS10825	COG4466	Protein conserved in bacteria
HWH77_RS10840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWH77_RS10845	COG0251	oxidation-reduction process
HWH77_RS10860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWH77_RS10880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWH77_RS10885	COG2002	toxin-antitoxin pair type II binding
HWH77_RS10890	COG2244	polysaccharide biosynthetic process
HWH77_RS10895	COG3956	TIGRFAM MazG family protein
HWH77_RS10900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWH77_RS10915	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWH77_RS10920	COG1098	S1 RNA binding domain
HWH77_RS10935	COG2208	phosphoserine phosphatase activity
HWH77_RS10940	COG2304	oxidoreductase activity
HWH77_RS10945	COG0515	serine threonine protein kinase
HWH77_RS10950	COG0037	tRNA processing
HWH77_RS10955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HWH77_RS10960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWH77_RS10975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWH77_RS10980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWH77_RS10985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWH77_RS10990	COG0512	Glutamine amidotransferase of anthranilate synthase
HWH77_RS10995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS11000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWH77_RS11005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWH77_RS11010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWH77_RS11015	COG1396	sequence-specific DNA binding
HWH77_RS11020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWH77_RS11025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HWH77_RS11105	COG4463	regulation of RNA biosynthetic process
HWH77_RS11110	COG3880	PFAM UvrB UvrC protein
HWH77_RS11120	COG0542	response to heat
HWH77_RS11125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HWH77_RS11130	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HWH77_RS11135	COG4956	integral membrane protein (PIN domain superfamily)
HWH77_RS11155	COG1045	serine acetyltransferase
HWH77_RS11165	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HWH77_RS11170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWH77_RS11175	COG3688	RNA-binding protein containing a PIN domain
HWH77_RS11180	COG1595	DNA-templated transcription, initiation
HWH77_RS11190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWH77_RS11195	COG0250	Participates in transcription elongation, termination and antitermination
HWH77_RS11220	COG2813	Specifically methylates the guanine in position
HWH77_RS11235	COG1358	cellular component organization or biogenesis
HWH77_RS11260	COG0596	Alpha beta hydrolase
HWH77_RS11370	COG0201	protein transport
HWH77_RS11380	COG0024	Methionine aminopeptidase
HWH77_RS11390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWH77_RS11415	COG1122	ATPase activity
HWH77_RS11420	COG1122	ATPase activity
HWH77_RS11425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWH77_RS11445	COG2226	methyltransferase
HWH77_RS11450	COG2318	DinB family
HWH77_RS11460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS11465	COG0489	protein tyrosine kinase activity
HWH77_RS11475	COG2194	sulfuric ester hydrolase activity
HWH77_RS11480	COG0726	polysaccharide deacetylase
HWH77_RS11540	COG0738	Major facilitator superfamily
HWH77_RS11545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS11560	COG0659	secondary active sulfate transmembrane transporter activity
HWH77_RS11565	COG0385	Bile acid
HWH77_RS11570	COG2819	hydrolase of the alpha beta superfamily
HWH77_RS11575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS11580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS11585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWH77_RS11590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWH77_RS11590	COG2207	Transcriptional regulator
HWH77_RS11595	COG3876	Protein conserved in bacteria
HWH77_RS11600	COG1472	Belongs to the glycosyl hydrolase 3 family
HWH77_RS11605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWH77_RS11610	COG1263	PTS System
HWH77_RS11610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS11620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWH77_RS11625	COG1683	Conserved Protein
HWH77_RS11655	COG1595	DNA-templated transcription, initiation
HWH77_RS11660	COG5662	AntiSigma factor
HWH77_RS11665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWH77_RS11670	COG4856	YbbR-like protein
HWH77_RS11710	COG1346	cytolysis
HWH77_RS11715	COG1380	Effector of murein hydrolase LrgA
HWH77_RS11720	COG1846	Transcriptional regulator
HWH77_RS11725	COG1113	amino acid transport
HWH77_RS11730	COG1011	Hydrolase
HWH77_RS11735	COG4585	Histidine kinase
HWH77_RS11740	COG2197	response regulator
HWH77_RS11745	COG1131	(ABC) transporter
HWH77_RS11785	COG0531	amino acid
HWH77_RS11790	COG0584	glycerophosphoryl diester phosphodiesterase
HWH77_RS11795	COG2271	Major facilitator Superfamily
HWH77_RS11805	COG2368	4-hydroxyphenylacetate
HWH77_RS11815	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS11830	COG0371	Dehydrogenase
HWH77_RS11840	COG1183	phosphatidylcholine synthase activity
HWH77_RS11845	COG0586	Pfam SNARE associated Golgi protein
HWH77_RS11850	COG0688	phosphatidylethanolamine metabolic process
HWH77_RS11865	COG1301	dicarboxylic acid transport
HWH77_RS11870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS11875	COG0833	amino acid
HWH77_RS11880	COG2040	homocysteine
HWH77_RS11885	COG1115	amino acid carrier protein
HWH77_RS11890	COG2066	Belongs to the glutaminase family
HWH77_RS11895	COG4191	Histidine kinase
HWH77_RS11900	COG0784	Response regulator, receiver
HWH77_RS11905	COG3173	Aminoglycoside phosphotransferase
HWH77_RS11915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWH77_RS11920	COG0778	Nitroreductase
HWH77_RS11925	COG0346	lactoylglutathione lyase activity
HWH77_RS11930	COG2259	Doxx family
HWH77_RS11935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS11950	COG3773	Cell wall hydrolase
HWH77_RS11955	COG3540	Alkaline phosphatase
HWH77_RS11960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWH77_RS11965	COG0805	protein transport
HWH77_RS11975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWH77_RS11980	COG0477	Major facilitator Superfamily
HWH77_RS11985	COG1309	transcriptional regulator
HWH77_RS11990	COG0252	asparaginase activity
HWH77_RS11995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWH77_RS12000	COG1405	negative regulation of cell septum assembly
HWH77_RS12000	COG3012	SEC-C Motif Domain Protein
HWH77_RS12005	COG0667	Aldo Keto reductase
HWH77_RS12015	COG1595	DNA-templated transcription, initiation
HWH77_RS12020	COG1595	DNA-templated transcription, initiation
HWH77_RS12025	COG1876	peptidase activity
HWH77_RS12030	COG0457	Tetratricopeptide repeat
HWH77_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS12040	COG0366	Alpha amylase catalytic
HWH77_RS12045	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWH77_RS12050	COG1121	(ABC) transporter
HWH77_RS12055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWH77_RS12060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS12065	COG2310	stress, protein
HWH77_RS12070	COG2310	stress, protein
HWH77_RS12075	COG2310	stress, protein
HWH77_RS12080	COG0861	Integral membrane protein TerC family
HWH77_RS12090	COG3853	Toxic anion resistance protein (TelA)
HWH77_RS12095	COG0477	Major facilitator Superfamily
HWH77_RS12100	COG0517	IMP dehydrogenase activity
HWH77_RS12100	COG4175	Glycine betaine
HWH77_RS12105	COG4176	ABC-type proline glycine betaine transport system permease component
HWH77_RS12110	COG2113	Glycine betaine
HWH77_RS12115	COG1473	amidohydrolase
HWH77_RS12120	COG1288	antiporter activity
HWH77_RS12130	COG0366	Alpha amylase catalytic
HWH77_RS12140	COG2814	Major facilitator Superfamily
HWH77_RS12145	COG1846	Transcriptional regulator
HWH77_RS12150	COG1280	lysine exporter protein (LysE YggA)
HWH77_RS12155	COG3403	YqcI/YcgG family
HWH77_RS12160	COG1113	amino acid transport
HWH77_RS12165	COG3665	Urea carboxylase-associated protein
HWH77_RS12180	COG1660	Displays ATPase and GTPase activities
HWH77_RS12190	COG2271	Major facilitator Superfamily
HWH77_RS12195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWH77_RS12200	COG3458	cephalosporin-C deacetylase activity
HWH77_RS12205	COG3541	Predicted nucleotidyltransferase
HWH77_RS12210	COG0506	proline dehydrogenase activity
HWH77_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS12220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWH77_RS12225	COG2508	Transcriptional regulator
HWH77_RS12235	COG1587	Uroporphyrinogen-III synthase
HWH77_RS12235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWH77_RS12240	COG2146	nitrite reductase [NAD(P)H] activity
HWH77_RS12245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWH77_RS12250	COG0523	cobalamin synthesis protein
HWH77_RS12255	COG1063	alcohol dehydrogenase
HWH77_RS12260	COG1714	RDD family
HWH77_RS12270	COG2723	6-phospho-beta-galactosidase activity
HWH77_RS12285	COG3209	COG3209 Rhs family protein
HWH77_RS12290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWH77_RS12295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HWH77_RS12300	COG1733	regulation of RNA biosynthetic process
HWH77_RS12305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS12310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS12320	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HWH77_RS12335	COG2364	Membrane
HWH77_RS12340	COG1126	abc transporter atp-binding protein
HWH77_RS12345	COG0765	amino acid transport
HWH77_RS12350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS12355	COG0583	DNA-binding transcription factor activity
HWH77_RS12360	COG0163	prenyltransferase activity
HWH77_RS12365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HWH77_RS12380	COG3104	oligopeptide transport
HWH77_RS12385	COG5434	Belongs to the glycosyl hydrolase 28 family
HWH77_RS12395	COG0697	spore germination
HWH77_RS12405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWH77_RS12410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWH77_RS12415	COG0456	acetyltransferase
HWH77_RS12420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWH77_RS12425	COG0765	amino acid transport
HWH77_RS12430	COG1126	abc transporter atp-binding protein
HWH77_RS12435	COG1473	amidohydrolase
HWH77_RS12440	COG2079	MmgE PrpD family protein
HWH77_RS12445	COG1136	(ABC) transporter
HWH77_RS12450	COG0577	efflux transmembrane transporter activity
HWH77_RS12455	COG0745	RESPONSE REGULATOR receiver
HWH77_RS12460	COG3850	Histidine kinase
HWH77_RS12460	COG5002	protein histidine kinase activity
HWH77_RS12465	COG0457	Tetratricopeptide repeat
HWH77_RS12480	COG0527	aspartate kinase activity
HWH77_RS12485	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWH77_RS12490	COG4605	iron ion homeostasis
HWH77_RS12495	COG4604	ABC transporter, ATP-binding protein
HWH77_RS12500	COG4607	ABC-type enterochelin transport system periplasmic component
HWH77_RS12505	COG2814	Major facilitator Superfamily
HWH77_RS12510	COG1309	transcriptional regulator
HWH77_RS12515	COG0778	Nitroreductase
HWH77_RS12520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWH77_RS12525	COG0640	Transcriptional regulator
HWH77_RS12530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWH77_RS12535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS12545	COG4975	Glucose uptake
HWH77_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS12555	COG4549	nuclear export factor GLE1
HWH77_RS12560	COG2372	response to copper ion
HWH77_RS12560	COG1276	copper resistance
HWH77_RS12565	COG1349	DNA-binding transcription factor activity
HWH77_RS12575	COG2213	PTS system mannitol-specific
HWH77_RS12580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS12590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWH77_RS12600	COG0561	phosphatase activity
HWH77_RS12610	COG1914	H( )-stimulated, divalent metal cation uptake system
HWH77_RS12620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWH77_RS12625	COG1984	allophanate hydrolase subunit 2
HWH77_RS12630	COG1414	Transcriptional regulator
HWH77_RS12635	COG2755	lipolytic protein G-D-S-L family
HWH77_RS12645	COG2329	Antibiotic biosynthesis monooxygenase
HWH77_RS12650	COG0768	penicillin binding
HWH77_RS12655	COG4989	oxidoreductase activity
HWH77_RS12660	COG3711	transcriptional antiterminator
HWH77_RS12665	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS12675	COG1917	Cupin 2, conserved barrel domain protein
HWH77_RS12680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWH77_RS12685	COG3871	stress protein (general stress protein 26)
HWH77_RS12695	COG2814	Major facilitator Superfamily
HWH77_RS12700	COG1522	sequence-specific DNA binding
HWH77_RS12705	COG0551	DNA topoisomerase type I activity
HWH77_RS12705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWH77_RS12710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HWH77_RS12715	COG3706	GGDEF domain
HWH77_RS12720	COG5298	Protein conserved in bacteria
HWH77_RS12725	COG1215	transferase activity, transferring glycosyl groups
HWH77_RS12735	COG0531	amino acid
HWH77_RS12740	COG0494	nUDIX hydrolase
HWH77_RS12745	COG0028	Belongs to the TPP enzyme family
HWH77_RS12795	COG0457	Tetratricopeptide repeat
HWH77_RS12815	COG1914	H( )-stimulated, divalent metal cation uptake system
HWH77_RS12825	COG4876	unkown
HWH77_RS12835	COG2076	Multidrug Resistance protein
HWH77_RS12840	COG2217	Heavy metal translocating P-type atpase
HWH77_RS12845	COG3729	General stress protein
HWH77_RS12850	COG0662	Cupin 2, conserved barrel domain protein
HWH77_RS12855	COG2329	Antibiotic biosynthesis monooxygenase
HWH77_RS12860	COG3546	catalase activity
HWH77_RS12865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HWH77_RS12870	COG3290	protein histidine kinase activity
HWH77_RS12875	COG4565	transcriptional regulatory protein
HWH77_RS12880	COG1301	dicarboxylic acid transport
HWH77_RS12885	COG0628	permease
HWH77_RS12890	COG1131	(ABC) transporter
HWH77_RS12895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWH77_RS12905	COG1960	acyl-CoA dehydrogenase activity
HWH77_RS12920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWH77_RS12925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS12935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWH77_RS12940	COG0513	Belongs to the DEAD box helicase family
HWH77_RS12945	COG3402	PFAM membrane-flanked domain
HWH77_RS12950	COG3428	Bacterial PH domain
HWH77_RS12955	COG0705	Rhomboid family
HWH77_RS12965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWH77_RS12970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWH77_RS12975	COG0864	Transcriptional regulator
HWH77_RS12980	COG2337	Toxic component of a toxin-antitoxin (TA) module
HWH77_RS12985	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS12990	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS12995	COG2172	sigma factor antagonist activity
HWH77_RS13000	COG2208	phosphoserine phosphatase activity
HWH77_RS13005	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS13015	COG1191	sigma factor activity
HWH77_RS13020	COG2208	phosphoserine phosphatase activity
HWH77_RS13025	COG2183	response to ionizing radiation
HWH77_RS13075	COG0457	Tetratricopeptide repeat
HWH77_RS13080	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWH77_RS13095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWH77_RS13110	COG1764	response to oxidative stress
HWH77_RS13115	COG1846	Transcriptional regulator
HWH77_RS13125	COG1959	2 iron, 2 sulfur cluster binding
HWH77_RS13130	COG2910	NAD(P)H-binding
HWH77_RS13135	COG1278	Cold shock
HWH77_RS13145	COG1937	Protein conserved in bacteria
HWH77_RS13150	COG2210	Belongs to the sulfur carrier protein TusA family
HWH77_RS13155	COG1054	Belongs to the UPF0176 family
HWH77_RS13160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWH77_RS13160	COG0425	Belongs to the sulfur carrier protein TusA family
HWH77_RS13165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS13165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWH77_RS13170	COG0425	Belongs to the sulfur carrier protein TusA family
HWH77_RS13175	COG0730	response to heat
HWH77_RS13180	COG1794	racemase activity, acting on amino acids and derivatives
HWH77_RS13195	COG3621	Patatin-like phospholipase
HWH77_RS13205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWH77_RS13210	COG1802	Transcriptional regulator
HWH77_RS13215	COG0251	oxidation-reduction process
HWH77_RS13220	COG0814	amino acid
HWH77_RS13225	COG1473	amidohydrolase
HWH77_RS13230	COG2207	Transcriptional regulator
HWH77_RS13230	COG1917	Cupin 2, conserved barrel domain protein
HWH77_RS13240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWH77_RS13245	COG0477	Major facilitator Superfamily
HWH77_RS13265	COG0277	FAD linked oxidase domain protein
HWH77_RS13295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWH77_RS13320	COG1064	alcohol dehydrogenase
HWH77_RS13325	COG0789	Transcriptional regulator
HWH77_RS13335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWH77_RS13345	COG2814	Major facilitator Superfamily
HWH77_RS13350	COG1309	transcriptional regulator
HWH77_RS13355	COG5577	PFAM Coat F domain
HWH77_RS13365	COG1063	alcohol dehydrogenase
HWH77_RS13370	COG5577	PFAM Coat F domain
HWH77_RS13380	COG4585	Histidine kinase
HWH77_RS13385	COG2197	response regulator
HWH77_RS13390	COG2409	Drug exporters of the RND superfamily
HWH77_RS13395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HWH77_RS13400	COG0488	(ABC) transporter
HWH77_RS13405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWH77_RS13410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS13420	COG2814	Major facilitator Superfamily
HWH77_RS13425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWH77_RS13435	COG0730	response to heat
HWH77_RS13440	COG0456	acetyltransferase
HWH77_RS13445	COG0789	Transcriptional regulator
HWH77_RS13445	COG4978	Transcriptional regulator
HWH77_RS13450	COG0697	spore germination
HWH77_RS13455	COG1051	belongs to the nudix hydrolase family
HWH77_RS13460	COG2226	methyltransferase
HWH77_RS13465	COG0473	3-isopropylmalate dehydrogenase activity
HWH77_RS13470	COG1802	Transcriptional regulator
HWH77_RS13475	COG1819	glycosyl
HWH77_RS13490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWH77_RS13500	COG1388	LysM domain
HWH77_RS13505	COG2814	Major facilitator Superfamily
HWH77_RS13510	COG2188	Transcriptional regulator
HWH77_RS13515	COG2186	Transcriptional regulator
HWH77_RS13520	COG2807	transmembrane transport
HWH77_RS13525	COG2076	Multidrug Resistance protein
HWH77_RS13530	COG2076	Multidrug Resistance protein
HWH77_RS13535	COG1309	transcriptional regulator
HWH77_RS13540	COG0531	amino acid
HWH77_RS13550	COG3832	glyoxalase III activity
HWH77_RS13555	COG0604	alcohol dehydrogenase
HWH77_RS13560	COG2814	Major facilitator Superfamily
HWH77_RS13600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWH77_RS13605	COG0802	atpase or kinase
HWH77_RS13610	COG1214	PFAM Peptidase M22, glycoprotease
HWH77_RS13615	COG0456	acetyltransferase
HWH77_RS13620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWH77_RS13625	COG0488	(ABC) transporter
HWH77_RS13640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWH77_RS13645	COG0805	protein transport
HWH77_RS13655	COG1266	CAAX protease self-immunity
HWH77_RS13735	COG1131	(ABC) transporter
HWH77_RS13740	COG0842	Transport permease protein
HWH77_RS13745	COG0457	Tetratricopeptide repeat
HWH77_RS13750	COG1063	alcohol dehydrogenase
HWH77_RS13755	COG2211	Major facilitator Superfamily
HWH77_RS13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWH77_RS13770	COG1842	Phage shock protein A
HWH77_RS13775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWH77_RS13780	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWH77_RS13785	COG4260	virion core protein, lumpy skin disease virus
HWH77_RS13790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWH77_RS13790	COG2755	lipolytic protein G-D-S-L family
HWH77_RS13800	COG1595	DNA-templated transcription, initiation
HWH77_RS13805	COG1063	alcohol dehydrogenase
HWH77_RS13810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWH77_RS13815	COG0823	Involved in the tonB-independent uptake of proteins
HWH77_RS13830	COG2132	Multicopper oxidase
HWH77_RS13835	COG1113	amino acid transport
HWH77_RS13840	COG0714	Associated with various cellular activities
HWH77_RS13845	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HWH77_RS13850	COG1305	Transglutaminase-like
HWH77_RS13870	COG2252	PERMEase
HWH77_RS13875	COG3064	Membrane
HWH77_RS13895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWH77_RS13900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWH77_RS13905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWH77_RS13910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWH77_RS13915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWH77_RS13930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HWH77_RS13940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWH77_RS13945	COG0138	bifunctional purine biosynthesis protein purh
HWH77_RS13950	COG0151	Belongs to the GarS family
HWH77_RS13960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWH77_RS13965	COG1470	cell adhesion involved in biofilm formation
HWH77_RS13970	COG4496	protein, YerC YecD
HWH77_RS13975	COG0069	glutamate synthase activity
HWH77_RS13985	COG0210	DNA helicase
HWH77_RS13995	COG4851	CamS sex pheromone cAM373 precursor
HWH77_RS14000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWH77_RS14005	COG1285	pathogenesis
HWH77_RS14010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWH77_RS14030	COG1309	transcriptional regulator
HWH77_RS14035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWH77_RS14040	COG1597	lipid kinase activity
HWH77_RS14045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWH77_RS14055	COG1131	(ABC) transporter
HWH77_RS14080	COG5444	nuclease activity
HWH77_RS14115	COG3546	catalase activity
HWH77_RS14120	COG0454	-acetyltransferase
HWH77_RS14130	COG2323	membrane
HWH77_RS14135	COG2329	Antibiotic biosynthesis monooxygenase
HWH77_RS14140	COG0346	lactoylglutathione lyase activity
HWH77_RS14145	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS14150	COG5583	Uncharacterized small protein (DUF2292)
HWH77_RS14155	COG0196	riboflavin kinase activity
HWH77_RS14160	COG0670	Belongs to the BI1 family
HWH77_RS14170	COG1846	Transcriptional regulator
HWH77_RS14175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWH77_RS14185	COG2124	cytochrome p450
HWH77_RS14185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWH77_RS14200	COG1131	(ABC) transporter
HWH77_RS14245	COG4106	trans-aconitate 2-methyltransferase activity
HWH77_RS14250	COG1368	sulfuric ester hydrolase activity
HWH77_RS14255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWH77_RS14260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS14265	COG1442	glycosyl transferase family 8
HWH77_RS14270	COG1216	Glycosyl transferase, family 2
HWH77_RS14275	COG1442	glycosyl transferase family 8
HWH77_RS14280	COG2223	nitrite transmembrane transporter activity
HWH77_RS14285	COG0531	amino acid
HWH77_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
HWH77_RS14295	COG0840	transmembrane signaling receptor activity
HWH77_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS14305	COG0457	Tetratricopeptide repeat
HWH77_RS14305	COG0463	Glycosyl transferase, family 2
HWH77_RS14310	COG0488	(ABC) transporter
HWH77_RS14315	COG0789	Transcriptional regulator
HWH77_RS14320	COG2814	Major facilitator Superfamily
HWH77_RS14325	COG0488	(ABC) transporter
HWH77_RS14330	COG0513	Belongs to the DEAD box helicase family
HWH77_RS14340	COG2130	NADP-dependent
HWH77_RS14355	COG3866	Pectate lyase
HWH77_RS14360	COG0471	metal ion transport
HWH77_RS14375	COG0745	RESPONSE REGULATOR receiver
HWH77_RS14375	COG2972	Histidine kinase
HWH77_RS14380	COG3279	Response regulator of the LytR AlgR family
HWH77_RS14390	COG3764	Sortase (surface protein transpeptidase)
HWH77_RS14395	COG3290	protein histidine kinase activity
HWH77_RS14400	COG4565	transcriptional regulatory protein
HWH77_RS14405	COG3181	Tripartite tricarboxylate transporter family receptor
HWH77_RS14410	COG2851	Citrate transporter
HWH77_RS14415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWH77_RS14420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HWH77_RS14430	COG2258	MOSC domain
HWH77_RS14450	COG0024	Methionine aminopeptidase
HWH77_RS14455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS14455	COG1263	PTS System
HWH77_RS14465	COG1368	sulfuric ester hydrolase activity
HWH77_RS14475	COG0071	Belongs to the small heat shock protein (HSP20) family
HWH77_RS14490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS14490	COG1263	PTS System
HWH77_RS14495	COG0366	Alpha amylase catalytic
HWH77_RS14500	COG2188	Transcriptional regulator
HWH77_RS14505	COG0778	Nitroreductase
HWH77_RS14520	COG0737	Belongs to the 5'-nucleotidase family
HWH77_RS14525	COG0693	protein deglycase activity
HWH77_RS14530	COG1609	Transcriptional regulator
HWH77_RS14545	COG2814	Major facilitator Superfamily
HWH77_RS14555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWH77_RS14560	COG4980	gas vesicle protein
HWH77_RS14565	COG1295	ribonuclease BN
HWH77_RS14570	COG0477	Major facilitator Superfamily
HWH77_RS14575	COG0387	Pfam Sodium calcium exchanger
HWH77_RS14585	COG0668	transmembrane transport
HWH77_RS14590	COG0535	radical SAM domain protein
HWH77_RS14600	COG0726	polysaccharide deacetylase
HWH77_RS14605	COG2084	Dehydrogenase
HWH77_RS14615	COG0598	Magnesium transport protein CorA
HWH77_RS14620	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWH77_RS14625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWH77_RS14635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWH77_RS14640	COG4637	Psort location Cytoplasmic, score
HWH77_RS14645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWH77_RS14650	COG0022	dehydrogenase e1 component
HWH77_RS14655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWH77_RS14660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWH77_RS14665	COG3284	Transcriptional regulator
HWH77_RS14675	COG1486	melibiose metabolic process
HWH77_RS14680	COG1737	Transcriptional regulator
HWH77_RS14685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS14685	COG1263	PTS System
HWH77_RS14690	COG1132	(ABC) transporter
HWH77_RS14695	COG1132	(ABC) transporter
HWH77_RS14700	COG2259	Doxx family
HWH77_RS14705	COG2514	catechol 2,3-dioxygenase activity
HWH77_RS14715	COG1695	Transcriptional regulator
HWH77_RS14720	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWH77_RS14725	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HWH77_RS14730	COG3848	Pyruvate phosphate dikinase
HWH77_RS14730	COG0574	Belongs to the PEP-utilizing enzyme family
HWH77_RS14735	COG2732	(Barnase) inhibitor
HWH77_RS14740	COG2318	DinB family
HWH77_RS14745	COG2814	Major facilitator Superfamily
HWH77_RS14750	COG1846	Transcriptional regulator
HWH77_RS14755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HWH77_RS14755	COG0392	lysyltransferase activity
HWH77_RS14760	COG0384	phenazine biosynthesis protein PhzF
HWH77_RS14765	COG0778	Nitroreductase
HWH77_RS14780	COG1090	epimerase
HWH77_RS14795	COG2814	Major facilitator Superfamily
HWH77_RS14805	COG3591	Belongs to the peptidase S1B family
HWH77_RS14820	COG3103	Sh3 type 3 domain protein
HWH77_RS14825	COG5658	integral membrane protein
HWH77_RS14830	COG0596	Alpha beta hydrolase
HWH77_RS14835	COG0463	Glycosyl transferase, family 2
HWH77_RS14840	COG4485	Bacterial membrane protein, YfhO
HWH77_RS14845	COG1988	membrane-bound metal-dependent
HWH77_RS14850	COG1194	a g-specific adenine glycosylase
HWH77_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS14880	COG1132	(ABC) transporter
HWH77_RS14885	COG4129	membrane
HWH77_RS14895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWH77_RS14900	COG0735	belongs to the Fur family
HWH77_RS15015	COG3340	Belongs to the peptidase S51 family
HWH77_RS15025	COG0277	FAD linked oxidase domain protein
HWH77_RS15035	COG0747	negative chemotaxis
HWH77_RS15040	COG0601	transmembrane transport
HWH77_RS15045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWH77_RS15050	COG0444	Belongs to the ABC transporter superfamily
HWH77_RS15055	COG4608	Belongs to the ABC transporter superfamily
HWH77_RS15060	COG0753	catalase activity
HWH77_RS15070	COG1116	anion transmembrane transporter activity
HWH77_RS15075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWH77_RS15080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWH77_RS15100	COG1476	TRANSCRIPTIONal
HWH77_RS15110	COG3382	B3 4 domain protein
HWH77_RS15115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWH77_RS15125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWH77_RS15130	COG0789	Transcriptional regulator
HWH77_RS15135	COG1664	Polymer-forming cytoskeletal
HWH77_RS15140	COG1664	Polymer-forming cytoskeletal
HWH77_RS15145	COG2766	serine protein kinase
HWH77_RS15155	COG1846	Transcriptional regulator
HWH77_RS15160	COG1566	PFAM secretion protein HlyD family protein
HWH77_RS15165	COG2814	Major facilitator Superfamily
HWH77_RS15170	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWH77_RS15185	COG1725	Transcriptional regulator
HWH77_RS15190	COG1131	(ABC) transporter
HWH77_RS15195	COG1131	(ABC) transporter
HWH77_RS15200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWH77_RS15205	COG1278	Cold shock
HWH77_RS15210	COG1464	Belongs to the NlpA lipoprotein family
HWH77_RS15215	COG3706	GGDEF domain
HWH77_RS15220	COG1823	symporter activity
HWH77_RS15240	COG5577	PFAM Coat F domain
HWH77_RS15250	COG3764	Sortase (surface protein transpeptidase)
HWH77_RS15255	COG0564	pseudouridine synthase activity
HWH77_RS15265	COG0517	IMP dehydrogenase activity
HWH77_RS15270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWH77_RS15275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWH77_RS15275	COG3153	acetyltransferase
HWH77_RS15280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWH77_RS15285	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HWH77_RS15290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWH77_RS15300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWH77_RS15305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWH77_RS15310	COG4585	Histidine kinase
HWH77_RS15310	COG2203	Gaf domain
HWH77_RS15315	COG2197	response regulator
HWH77_RS15320	COG0431	NADPH-dependent FMN reductase
HWH77_RS15335	COG0791	NLP P60 protein
HWH77_RS15335	COG1388	LysM domain
HWH77_RS15340	COG1959	2 iron, 2 sulfur cluster binding
HWH77_RS15345	COG0668	transmembrane transport
HWH77_RS15350	COG2719	SpoVR family
HWH77_RS15355	COG1785	Belongs to the alkaline phosphatase family
HWH77_RS15360	COG1388	LysM domain
HWH77_RS15360	COG0791	NLP P60 protein
HWH77_RS15365	COG0583	DNA-binding transcription factor activity
HWH77_RS15370	COG0372	Belongs to the citrate synthase family
HWH77_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS15380	COG0531	amino acid
HWH77_RS15385	COG0733	neurotransmitter:sodium symporter activity
HWH77_RS15400	COG1595	DNA-templated transcription, initiation
HWH77_RS15405	COG0204	Acyl-transferase
HWH77_RS15410	COG1253	flavin adenine dinucleotide binding
HWH77_RS15415	COG0789	Transcriptional regulator
HWH77_RS15420	COG0436	Aminotransferase
HWH77_RS15425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWH77_RS15430	COG1253	flavin adenine dinucleotide binding
HWH77_RS15435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWH77_RS15440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWH77_RS15445	COG0584	glycerophosphoryl diester phosphodiesterase
HWH77_RS15455	COG0668	transmembrane transport
HWH77_RS15460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWH77_RS15465	COG0726	polysaccharide deacetylase
HWH77_RS15470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWH77_RS15475	COG3226	Transcriptional regulator
HWH77_RS15485	COG0589	response to stress
HWH77_RS15490	COG1132	(ABC) transporter
HWH77_RS15495	COG1132	(ABC) transporter
HWH77_RS15500	COG0702	epimerase
HWH77_RS15515	COG0189	ligase activity
HWH77_RS15520	COG0189	ligase activity
HWH77_RS15535	COG4335	DNA alkylation repair
HWH77_RS15540	COG0561	phosphatase activity
HWH77_RS15545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWH77_RS15555	COG0475	glutathione-regulated potassium exporter activity
HWH77_RS15560	COG0490	domain, Protein
HWH77_RS15570	COG1024	Enoyl-CoA hydratase
HWH77_RS15580	COG4152	abc transporter atp-binding protein
HWH77_RS15585	COG1668	transmembrane transport
HWH77_RS15590	COG0420	3'-5' exonuclease activity
HWH77_RS15595	COG4717	serine-type aminopeptidase activity
HWH77_RS15610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWH77_RS15645	COG4980	gas vesicle protein
HWH77_RS15660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HWH77_RS15665	COG0537	adenosine 5'-monophosphoramidase activity
HWH77_RS15670	COG1131	(ABC) transporter
HWH77_RS15675	COG4473	ABC transporter
HWH77_RS15685	COG1473	amidohydrolase
HWH77_RS15690	COG3069	C4-dicarboxylate transmembrane transporter activity
HWH77_RS15695	COG2329	Antibiotic biosynthesis monooxygenase
HWH77_RS15700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWH77_RS15710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HWH77_RS15715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HWH77_RS15720	COG1309	transcriptional regulator
HWH77_RS15725	COG1511	domain protein
HWH77_RS15730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWH77_RS15740	COG1363	Peptidase, m42
HWH77_RS15745	COG1301	dicarboxylic acid transport
HWH77_RS15755	COG1234	tRNA 3'-trailer cleavage
HWH77_RS15760	COG0095	Lipoate-protein ligase
HWH77_RS15765	COG0702	epimerase
HWH77_RS15770	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS15780	COG0501	Belongs to the peptidase M48B family
HWH77_RS15785	COG1404	Belongs to the peptidase S8 family
HWH77_RS15790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWH77_RS15795	COG0406	alpha-ribazole phosphatase activity
HWH77_RS15800	COG0183	Belongs to the thiolase family
HWH77_RS15805	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS15810	COG1268	BioY protein
HWH77_RS15815	COG0840	transmembrane signaling receptor activity
HWH77_RS15820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWH77_RS15820	COG0723	plastoquinol--plastocyanin reductase activity
HWH77_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS15835	COG4903	ComK protein
HWH77_RS15845	COG5646	InterPro IPR014922
HWH77_RS15865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWH77_RS15880	COG0398	Pfam SNARE associated Golgi protein
HWH77_RS15885	COG0681	Belongs to the peptidase S26 family
HWH77_RS15890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWH77_RS15895	COG1846	Transcriptional regulator
HWH77_RS15900	COG3180	Ammonia monooxygenase
HWH77_RS15905	COG2814	Major facilitator Superfamily
HWH77_RS15915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HWH77_RS15920	COG2323	membrane
HWH77_RS15935	COG0420	3'-5' exonuclease activity
HWH77_RS15940	COG0419	ATPase involved in DNA repair
HWH77_RS15945	COG1403	HNH endonuclease
HWH77_RS15985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWH77_RS16005	COG0367	asparagine synthase
HWH77_RS16010	COG1562	ergosterol biosynthetic process
HWH77_RS16015	COG0534	Mate efflux family protein
HWH77_RS16020	COG1917	Cupin 2, conserved barrel domain protein
HWH77_RS16020	COG2207	Transcriptional regulator
HWH77_RS16025	COG1609	Transcriptional regulator
HWH77_RS16030	COG0673	inositol 2-dehydrogenase activity
HWH77_RS16035	COG2318	DinB family
HWH77_RS16040	COG1357	PFAM Pentapeptide repeats (8 copies)
HWH77_RS16045	COG2153	protein acetylation
HWH77_RS16050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWH77_RS16050	COG0646	methionine synthase
HWH77_RS16060	COG2996	Protein conserved in bacteria
HWH77_RS16065	COG1744	ABC transporter substrate-binding protein PnrA-like
HWH77_RS16070	COG0840	transmembrane signaling receptor activity
HWH77_RS16080	COG1307	EDD domain protein, DegV family
HWH77_RS16085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWH77_RS16105	COG0561	phosphatase activity
HWH77_RS16110	COG1073	alpha beta
HWH77_RS16115	COG2151	metal-sulfur cluster biosynthetic enzyme
HWH77_RS16125	COG0277	FAD linked oxidase domain protein
HWH77_RS16130	COG2271	Major facilitator Superfamily
HWH77_RS16140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWH77_RS16150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWH77_RS16155	COG0505	Belongs to the CarA family
HWH77_RS16160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWH77_RS16165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HWH77_RS16180	COG2267	carboxylic ester hydrolase activity
HWH77_RS16190	COG1744	ABC transporter substrate-binding protein PnrA-like
HWH77_RS16205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWH77_RS16210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWH77_RS16215	COG5504	Zn-dependent protease
HWH77_RS16220	COG0444	Belongs to the ABC transporter superfamily
HWH77_RS16225	COG4608	Belongs to the ABC transporter superfamily
HWH77_RS16235	COG0601	transmembrane transport
HWH77_RS16240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWH77_RS16260	COG0180	Tryptophanyl-tRNA synthetase
HWH77_RS16265	COG4166	transmembrane transport
HWH77_RS16270	COG0601	transmembrane transport
HWH77_RS16275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWH77_RS16280	COG0444	Belongs to the ABC transporter superfamily
HWH77_RS16285	COG4608	Belongs to the ABC transporter superfamily
HWH77_RS16295	COG0456	acetyltransferase
HWH77_RS16300	COG1393	Belongs to the ArsC family
HWH77_RS16305	COG0861	Integral membrane protein TerC family
HWH77_RS16315	COG4862	establishment of competence for transformation
HWH77_RS16320	COG4469	Competence protein
HWH77_RS16325	COG1164	Oligoendopeptidase f
HWH77_RS16335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWH77_RS16340	COG2346	COG2346, Truncated hemoglobins
HWH77_RS16345	COG0741	lytic transglycosylase activity
HWH77_RS16350	COG4116	CYTH
HWH77_RS16360	COG2357	RelA SpoT domain protein
HWH77_RS16365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWH77_RS16370	COG0564	pseudouridine synthase activity
HWH77_RS16380	COG0569	domain protein
HWH77_RS16380	COG0475	glutathione-regulated potassium exporter activity
HWH77_RS16385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWH77_RS16390	COG0352	thiamine-phosphate diphosphorylase activity
HWH77_RS16395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWH77_RS16400	COG2104	thiamine diphosphate biosynthetic process
HWH77_RS16410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWH77_RS16415	COG0351	phosphomethylpyrimidine kinase
HWH77_RS16420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWH77_RS16475	COG0210	DNA helicase
HWH77_RS16495	COG1131	(ABC) transporter
HWH77_RS16505	COG2153	protein acetylation
HWH77_RS16515	COG2382	esterase
HWH77_RS16520	COG0626	cystathionine gamma-synthase activity
HWH77_RS16525	COG0626	cystathionine gamma-synthase activity
HWH77_RS16540	COG5444	nuclease activity
HWH77_RS16550	COG0346	lactoylglutathione lyase activity
HWH77_RS16555	COG2367	Beta-lactamase
HWH77_RS16560	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWH77_RS16565	COG0477	Major facilitator Superfamily
HWH77_RS16570	COG1846	Transcriptional regulator
HWH77_RS16580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HWH77_RS16585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWH77_RS16590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HWH77_RS16595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS16595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWH77_RS16600	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWH77_RS16610	COG1349	DNA-binding transcription factor activity
HWH77_RS16625	COG1285	pathogenesis
HWH77_RS16635	COG2205	protein histidine kinase activity
HWH77_RS16645	COG3383	formate dehydrogenase (NAD+) activity
HWH77_RS16650	COG2427	Protein of unknown function (DUF1641)
HWH77_RS16655	COG2124	cytochrome p450
HWH77_RS16660	COG1819	glycosyl
HWH77_RS16670	COG1587	Uroporphyrinogen-III synthase
HWH77_RS16675	COG0390	transport system, permease component
HWH77_RS16680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWH77_RS16685	COG0697	spore germination
HWH77_RS16690	COG4297	protein containing double-stranded beta helix domain
HWH77_RS16700	COG1252	NADH dehydrogenase
HWH77_RS16710	COG2211	Major facilitator Superfamily
HWH77_RS16715	COG1609	Transcriptional regulator
HWH77_RS16720	COG0246	Mannitol dehydrogenase
HWH77_RS16725	COG2721	sulfolactate sulfo-lyase activity
HWH77_RS16730	COG0745	RESPONSE REGULATOR receiver
HWH77_RS16735	COG2770	Histidine kinase
HWH77_RS16735	COG2205	protein histidine kinase activity
HWH77_RS16750	COG0730	response to heat
HWH77_RS16755	COG2318	DinB family
HWH77_RS16760	COG0457	Tetratricopeptide repeat
HWH77_RS16770	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS16770	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS16770	COG1388	LysM domain
HWH77_RS16780	COG4195	phage-related replication protein
HWH77_RS16785	COG2856	Zn peptidase
HWH77_RS16790	COG1396	sequence-specific DNA binding
HWH77_RS16800	COG1522	sequence-specific DNA binding
HWH77_RS16805	COG1484	DNA-dependent DNA replication
HWH77_RS16825	COG1595	DNA-templated transcription, initiation
HWH77_RS16830	COG5484	DNA packaging
HWH77_RS16830	COG3728	DNA packaging
HWH77_RS16835	COG1783	phage Terminase large subunit
HWH77_RS16840	COG5518	Phage portal protein
HWH77_RS16845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HWH77_RS16850	COG4653	Phage capsid family
HWH77_RS16900	COG5412	phage tail tape measure protein
HWH77_RS16900	COG5412	phage tail tape measure protein
HWH77_RS16900	COG3953	SLT domain
HWH77_RS16900	COG5412	phage tail tape measure protein
HWH77_RS16900	COG3953	SLT domain
HWH77_RS16900	COG3953	SLT domain
HWH77_RS16905	COG1652	LysM domain
HWH77_RS16910	COG4193	domain, Protein
HWH77_RS16920	COG3628	GPW Gp25 family protein
HWH77_RS16925	COG3299	homolog of phage Mu protein gp47
HWH77_RS16930	COG3778	Protein conserved in bacteria
HWH77_RS16970	COG3409	Peptidoglycan-binding domain 1 protein
HWH77_RS16970	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS16985	COG0306	phosphate transporter
HWH77_RS16990	COG1392	Phosphate transport regulator
HWH77_RS16995	COG0531	amino acid
HWH77_RS17000	COG0346	lactoylglutathione lyase activity
HWH77_RS17005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWH77_RS17010	COG0463	Glycosyl transferase, family 2
HWH77_RS17020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWH77_RS17025	COG0477	Major facilitator Superfamily
HWH77_RS17030	COG2362	D-Aminopeptidase
HWH77_RS17035	COG0601	transmembrane transport
HWH77_RS17040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWH77_RS17045	COG0444	Belongs to the ABC transporter superfamily
HWH77_RS17050	COG4166	transmembrane transport
HWH77_RS17055	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWH77_RS17060	COG4948	Mandelate Racemase Muconate Lactonizing
HWH77_RS17065	COG0791	NLP P60 protein
HWH77_RS17070	COG4608	Belongs to the ABC transporter superfamily
HWH77_RS17075	COG2706	6-phosphogluconolactonase activity
HWH77_RS17080	COG1834	amidinotransferase
HWH77_RS17085	COG1607	acyl-coa hydrolase
HWH77_RS17090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWH77_RS17095	COG2076	Multidrug Resistance protein
HWH77_RS17100	COG2076	Multidrug Resistance protein
HWH77_RS17105	COG0788	formyltetrahydrofolate deformylase activity
HWH77_RS17110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWH77_RS17120	COG1764	response to oxidative stress
HWH77_RS17125	COG1846	Transcriptional regulator
HWH77_RS17130	COG1764	response to oxidative stress
HWH77_RS17145	COG0463	Glycosyl transferase, family 2
HWH77_RS17145	COG0457	Tetratricopeptide repeat
HWH77_RS17155	COG2814	Major facilitator Superfamily
HWH77_RS17160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWH77_RS17170	COG1404	Belongs to the peptidase S8 family
HWH77_RS17175	COG1366	Belongs to the anti-sigma-factor antagonist family
HWH77_RS17180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWH77_RS17185	COG1122	ATPase activity
HWH77_RS17190	COG4721	ABC-type cobalt transport system, permease component
HWH77_RS17195	COG3858	chitin binding
HWH77_RS17195	COG1388	LysM domain
HWH77_RS17205	COG2239	Acts as a magnesium transporter
HWH77_RS17210	COG0789	Transcriptional regulator
HWH77_RS17225	COG1846	Transcriptional regulator
HWH77_RS17230	COG0726	polysaccharide deacetylase
HWH77_RS17235	COG3285	dna ligase
HWH77_RS17235	COG1793	dna ligase
HWH77_RS17240	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HWH77_RS17245	COG0586	Pfam SNARE associated Golgi protein
HWH77_RS17250	COG0861	Integral membrane protein TerC family
HWH77_RS17255	COG1191	sigma factor activity
HWH77_RS17280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWH77_RS17285	COG2323	membrane
HWH77_RS17295	COG3594	Acyltransferase
HWH77_RS17300	COG5002	protein histidine kinase activity
HWH77_RS17305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWH77_RS17320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWH77_RS17325	COG0436	Aminotransferase
HWH77_RS17355	COG3852	Histidine kinase
HWH77_RS17360	COG1846	Transcriptional regulator
HWH77_RS17365	COG1360	Flagellar Motor Protein
HWH77_RS17370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWH77_RS17375	COG0542	response to heat
HWH77_RS17380	COG3949	Membrane
HWH77_RS17395	COG0720	synthase
HWH77_RS17400	COG0602	queuosine metabolic process
HWH77_RS17410	COG1733	regulation of RNA biosynthetic process
HWH77_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS17435	COG4873	Protein conserved in bacteria
HWH77_RS17445	COG3773	Cell wall hydrolase
HWH77_RS17450	COG2244	polysaccharide biosynthetic process
HWH77_RS17455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS17460	COG2217	Heavy metal translocating P-type atpase
HWH77_RS17465	COG0006	proline dipeptidase activity
HWH77_RS17470	COG1609	Transcriptional regulator
HWH77_RS17475	COG3711	transcriptional antiterminator
HWH77_RS17480	COG1263	PTS System
HWH77_RS17480	COG2190	(PTS) system
HWH77_RS17480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWH77_RS17485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS17490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWH77_RS17500	COG1533	DNA photolyase activity
HWH77_RS17505	COG0840	transmembrane signaling receptor activity
HWH77_RS17510	COG2084	Dehydrogenase
HWH77_RS17515	COG2340	Cysteine-rich secretory protein family
HWH77_RS17520	COG0768	penicillin binding
HWH77_RS17525	COG4191	Histidine kinase
HWH77_RS17530	COG0436	Aminotransferase
HWH77_RS17540	COG0835	chemotaxis
HWH77_RS17540	COG0784	Response regulator, receiver
HWH77_RS17550	COG2814	Major facilitator Superfamily
HWH77_RS17555	COG1376	ErfK ybiS ycfS ynhG family protein
HWH77_RS17560	COG1408	metallophosphoesterase
HWH77_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS17575	COG2200	EAL domain
HWH77_RS17580	COG4703	Protein of unknown function (DUF1797)
HWH77_RS17585	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HWH77_RS17595	COG0517	IMP dehydrogenase activity
HWH77_RS17600	COG0583	DNA-binding transcription factor activity
HWH77_RS17605	COG0716	FMN binding
HWH77_RS17615	COG0716	FMN binding
HWH77_RS17635	COG0668	transmembrane transport
HWH77_RS17640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS17660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWH77_RS17665	COG0303	'Molybdopterin
HWH77_RS17670	COG1763	Mo-molybdopterin cofactor biosynthetic process
HWH77_RS17675	COG0314	molybdopterin synthase activity
HWH77_RS17680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HWH77_RS17690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWH77_RS17695	COG1136	(ABC) transporter
HWH77_RS17700	COG0577	efflux transmembrane transporter activity
HWH77_RS17705	COG1349	DNA-binding transcription factor activity
HWH77_RS17710	COG1105	Belongs to the carbohydrate kinase PfkB family
HWH77_RS17715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWH77_RS17715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWH77_RS17715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWH77_RS17720	COG0681	Belongs to the peptidase S26 family
HWH77_RS17730	COG0488	(ABC) transporter
HWH77_RS17735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWH77_RS17740	COG2309	aminopeptidase activity
HWH77_RS17750	COG1077	Cell shape determining protein MreB Mrl
HWH77_RS17755	COG2002	toxin-antitoxin pair type II binding
HWH77_RS17760	COG3852	Histidine kinase
HWH77_RS17765	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HWH77_RS17765	COG2105	PFAM AIG2 family protein
HWH77_RS17770	COG0569	domain protein
HWH77_RS17780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWH77_RS17790	COG0561	phosphatase activity
HWH77_RS17795	COG0242	peptide deformylase activity
HWH77_RS17805	COG0497	DNA recombination
HWH77_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS17815	COG3321	synthase
HWH77_RS17815	COG4221	oxidoreductase activity
HWH77_RS17815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS17820	COG0300	oxidoreductase activity
HWH77_RS17820	COG3321	synthase
HWH77_RS17820	COG4221	oxidoreductase activity
HWH77_RS17820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS17825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS17825	COG4221	oxidoreductase activity
HWH77_RS17825	COG3321	synthase
HWH77_RS17830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS17830	COG0300	oxidoreductase activity
HWH77_RS17830	COG4221	oxidoreductase activity
HWH77_RS17830	COG3321	synthase
HWH77_RS17835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS17835	COG0300	oxidoreductase activity
HWH77_RS17835	COG4221	oxidoreductase activity
HWH77_RS17835	COG3321	synthase
HWH77_RS17840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS17840	COG3321	synthase
HWH77_RS17840	COG4221	oxidoreductase activity
HWH77_RS17840	COG0300	oxidoreductase activity
HWH77_RS17845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS17845	COG3321	synthase
HWH77_RS17845	COG4221	oxidoreductase activity
HWH77_RS17850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWH77_RS17855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWH77_RS17860	COG0022	dehydrogenase e1 component
HWH77_RS17865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWH77_RS17870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWH77_RS17875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS17890	COG1982	Orn Lys Arg decarboxylase major
HWH77_RS17910	COG0483	inositol monophosphate 1-phosphatase activity
HWH77_RS17920	COG3227	Zinc metalloprotease (Elastase)
HWH77_RS17935	COG1595	DNA-templated transcription, initiation
HWH77_RS17955	COG1217	gtp-binding protein TYPA
HWH77_RS17965	COG4896	Protein conserved in bacteria
HWH77_RS17975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWH77_RS17980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWH77_RS17985	COG2066	Belongs to the glutaminase family
HWH77_RS17995	COG0772	Belongs to the SEDS family
HWH77_RS18000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HWH77_RS18015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWH77_RS18015	COG2010	Cytochrome c
HWH77_RS18020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWH77_RS18025	COG1845	cytochrome c oxidase, subunit III
HWH77_RS18030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWH77_RS18035	COG3336	cytochrome c oxidase
HWH77_RS18045	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HWH77_RS18050	COG2340	Cysteine-rich secretory protein family
HWH77_RS18065	COG3679	Belongs to the UPF0342 family
HWH77_RS18080	COG0742	ribosomal rna small subunit methyltransferase
HWH77_RS18090	COG3314	Sporulation integral membrane protein YlbJ
HWH77_RS18095	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWH77_RS18100	COG3480	Lon protease (S16) C-terminal proteolytic domain
HWH77_RS18110	COG1399	metal-binding, possibly nucleic acid-binding protein
HWH77_RS18130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWH77_RS18150	COG4839	cell division protein FtsL
HWH77_RS18155	COG0768	penicillin binding
HWH77_RS18160	COG0768	penicillin binding
HWH77_RS18180	COG0772	Belongs to the SEDS family
HWH77_RS18195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWH77_RS18200	COG0849	cell division
HWH77_RS18205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWH77_RS18210	COG4412	M6 family metalloprotease domain protein
HWH77_RS18210	COG1404	Belongs to the peptidase S8 family
HWH77_RS18220	COG1191	sigma factor activity
HWH77_RS18225	COG1191	sigma factor activity
HWH77_RS18230	COG1119	ATPase activity
HWH77_RS18235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWH77_RS18240	COG1873	PFAM PRC-barrel domain
HWH77_RS18245	COG1496	oxidoreductase activity
HWH77_RS18250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HWH77_RS18260	COG0762	integral membrane protein
HWH77_RS18265	COG2302	S4 RNA-binding domain
HWH77_RS18270	COG3599	regulation of cell shape
HWH77_RS18275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWH77_RS18280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWH77_RS18290	COG0564	pseudouridine synthase activity
HWH77_RS18300	COG2233	PERMEase
HWH77_RS18310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWH77_RS18315	COG0505	Belongs to the CarA family
HWH77_RS18320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWH77_RS18335	COG0284	orotidine-5'-phosphate decarboxylase activity
HWH77_RS18340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWH77_RS18350	COG0306	phosphate transporter
HWH77_RS18365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWH77_RS18370	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HWH77_RS18375	COG1648	precorrin-2 dehydrogenase activity
HWH77_RS18385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWH77_RS18390	COG1561	YicC-like family, N-terminal region
HWH77_RS18400	COG0194	GDP metabolic process
HWH77_RS18410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWH77_RS18415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWH77_RS18420	COG0242	peptide deformylase activity
HWH77_RS18430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWH77_RS18430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWH77_RS18440	COG0631	protein serine/threonine phosphatase activity
HWH77_RS18445	COG0515	serine threonine protein kinase
HWH77_RS18445	COG2815	serine threonine protein kinase
HWH77_RS18455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWH77_RS18460	COG1564	THIamine pyrophosphokinase
HWH77_RS18475	COG1302	Protein conserved in bacteria
HWH77_RS18480	COG1461	Dihydroxyacetone kinase
HWH77_RS18485	COG1760	l-serine dehydratase
HWH77_RS18490	COG1760	l-serine dehydratase
HWH77_RS18495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWH77_RS18510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWH77_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS18530	COG1196	nuclear chromosome segregation
HWH77_RS18535	COG0552	protein localization to endoplasmic reticulum
HWH77_RS18550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWH77_RS18560	COG1837	Belongs to the UPF0109 family
HWH77_RS18585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWH77_RS18600	COG2257	FlhB HrpN YscU SpaS Family
HWH77_RS18610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HWH77_RS18615	COG0758	DNA mediated transformation
HWH77_RS18620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWH77_RS18630	COG4974	Belongs to the 'phage' integrase family
HWH77_RS18650	COG1815	bacterial-type flagellum-dependent cell motility
HWH77_RS18655	COG1558	bacterial-type flagellum-dependent cell motility
HWH77_RS18660	COG1677	Flagellar hook-basal body complex protein FliE
HWH77_RS18665	COG1766	The M ring may be actively involved in energy transduction
HWH77_RS18670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWH77_RS18675	COG1317	bacterial-type flagellum organization
HWH77_RS18680	COG1157	protein secretion by the type III secretion system
HWH77_RS18685	COG2882	bacterial-type flagellum organization
HWH77_RS18690	COG3334	PFAM MgtE intracellular
HWH77_RS18695	COG3144	bacterial-type flagellum assembly
HWH77_RS18700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HWH77_RS18705	COG4786	Flagellar basal body rod
HWH77_RS18710	COG1582	Flagellar protein (FlbD)
HWH77_RS18715	COG1580	Controls the rotational direction of flagella during chemotaxis
HWH77_RS18720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWH77_RS18725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWH77_RS18725	COG1776	CheC inhibitor of MCP methylation
HWH77_RS18730	COG2201	protein-glutamate methylesterase activity
HWH77_RS18735	COG3190	flagellar
HWH77_RS18740	COG1338	Plays a role in the flagellum-specific transport system
HWH77_RS18745	COG1987	bacterial-type flagellum assembly
HWH77_RS18750	COG1684	flagellar biosynthetic protein fliR
HWH77_RS18755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWH77_RS18760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWH77_RS18765	COG1419	protein localization to endoplasmic reticulum
HWH77_RS18770	COG0455	bacterial-type flagellum organization
HWH77_RS18775	COG2201	protein-glutamate methylesterase activity
HWH77_RS18780	COG2198	Histidine kinase
HWH77_RS18780	COG0643	Histidine kinase
HWH77_RS18785	COG0835	chemotaxis
HWH77_RS18790	COG1776	CheC inhibitor of MCP methylation
HWH77_RS18800	COG1191	sigma factor activity
HWH77_RS18830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWH77_RS18835	COG4589	Belongs to the CDS family
HWH77_RS18845	COG0750	zinc metalloprotease
HWH77_RS18855	COG2176	DNA-directed DNA polymerase activity
HWH77_RS18865	COG0195	Participates in both transcription termination and antitermination
HWH77_RS18870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HWH77_RS18875	COG1358	cellular component organization or biogenesis
HWH77_RS18885	COG1550	Protein conserved in bacteria
HWH77_RS18900	COG0196	riboflavin kinase activity
HWH77_RS18915	COG0726	polysaccharide deacetylase
HWH77_RS18920	COG0612	Peptidase, M16
HWH77_RS18925	COG1873	PFAM PRC-barrel domain
HWH77_RS18930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWH77_RS18935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWH77_RS18940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HWH77_RS18945	COG0527	aspartate kinase activity
HWH77_RS18955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWH77_RS18960	COG0740	serine-type endopeptidase activity
HWH77_RS18970	COG4980	gas vesicle protein
HWH77_RS18970	COG1674	ftsk spoiiie
HWH77_RS18975	COG2188	Transcriptional regulator
HWH77_RS18980	COG2814	Major facilitator Superfamily
HWH77_RS18985	COG1846	Transcriptional regulator
HWH77_RS18990	COG1033	growth of symbiont in host cell
HWH77_RS18990	COG2409	Drug exporters of the RND superfamily
HWH77_RS18995	COG0612	Peptidase, M16
HWH77_RS19000	COG0612	Peptidase, M16
HWH77_RS19005	COG0300	oxidoreductase activity
HWH77_RS19020	COG1426	Protein conserved in bacteria
HWH77_RS19025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWH77_RS19040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWH77_RS19050	COG1692	metallophosphoesterase
HWH77_RS19055	COG2359	stage V sporulation protein S
HWH77_RS19075	COG4550	Control of competence regulator ComK, YlbF/YmcA
HWH77_RS19120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS19125	COG3425	synthase
HWH77_RS19130	COG1024	Enoyl-CoA hydratase
HWH77_RS19135	COG1024	Enoyl-CoA hydratase
HWH77_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS19140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS19140	COG3321	synthase
HWH77_RS19140	COG0300	oxidoreductase activity
HWH77_RS19140	COG0318	PFAM AMP-dependent synthetase and ligase
HWH77_RS19145	COG4221	oxidoreductase activity
HWH77_RS19145	COG3321	synthase
HWH77_RS19145	COG0300	oxidoreductase activity
HWH77_RS19145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS19150	COG3321	synthase
HWH77_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS19150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS19150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS19150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS19150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS19150	COG3321	synthase
HWH77_RS19150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS19150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWH77_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS19155	COG3321	synthase
HWH77_RS19155	COG4221	oxidoreductase activity
HWH77_RS19155	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS19155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWH77_RS19160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWH77_RS19160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWH77_RS19160	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWH77_RS19160	COG3321	synthase
HWH77_RS19165	COG2124	cytochrome p450
HWH77_RS19170	COG3209	COG3209 Rhs family protein
HWH77_RS19175	COG3619	membrane
HWH77_RS19185	COG1404	Belongs to the peptidase S8 family
HWH77_RS19195	COG4195	phage-related replication protein
HWH77_RS19200	COG1764	response to oxidative stress
HWH77_RS19210	COG2076	Multidrug Resistance protein
HWH77_RS19250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWH77_RS19255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWH77_RS19260	COG4112	unkown
HWH77_RS19265	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWH77_RS19270	COG0464	growth
HWH77_RS19275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWH77_RS19280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HWH77_RS19285	COG0789	Transcriptional regulator
HWH77_RS19290	COG0174	glutamine synthetase
HWH77_RS19300	COG2211	Major facilitator Superfamily
HWH77_RS19305	COG3507	Belongs to the glycosyl hydrolase 43 family
HWH77_RS19320	COG1070	Carbohydrate kinase
HWH77_RS19325	COG0574	Belongs to the PEP-utilizing enzyme family
HWH77_RS19325	COG3848	Pyruvate phosphate dikinase
HWH77_RS19345	COG2378	regulation of single-species biofilm formation
HWH77_RS19350	COG2318	DinB family
HWH77_RS19355	COG1064	alcohol dehydrogenase
HWH77_RS19370	COG0456	acetyltransferase
HWH77_RS19390	COG3397	chitin binding
HWH77_RS19410	COG5434	Belongs to the glycosyl hydrolase 28 family
HWH77_RS19415	COG0756	dUTP diphosphatase activity
HWH77_RS19420	COG4195	phage-related replication protein
HWH77_RS19455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWH77_RS19465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWH77_RS19485	COG0785	Cytochrome C biogenesis protein
HWH77_RS19490	COG2201	protein-glutamate methylesterase activity
HWH77_RS19495	COG4846	Membrane protein involved in cytochrome C biogenesis
HWH77_RS19505	COG0071	Belongs to the small heat shock protein (HSP20) family
HWH77_RS19520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWH77_RS19525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWH77_RS19545	COG0824	Thioesterase
HWH77_RS19555	COG4841	protein insertion into membrane
HWH77_RS19565	COG1832	CoA-binding protein
HWH77_RS19570	COG0187	DNA topoisomerase II activity
HWH77_RS19575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWH77_RS19585	COG1115	amino acid carrier protein
HWH77_RS19595	COG1063	alcohol dehydrogenase
HWH77_RS19600	COG0800	Aldolase
HWH77_RS19605	COG1312	Catalyzes the dehydration of D-mannonate
HWH77_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
HWH77_RS19615	COG1609	Transcriptional regulator
HWH77_RS19620	COG2271	Major facilitator Superfamily
HWH77_RS19655	COG2205	protein histidine kinase activity
HWH77_RS19660	COG0745	RESPONSE REGULATOR receiver
HWH77_RS19670	COG3507	Belongs to the glycosyl hydrolase 43 family