locus-tag	class	description
SB21_RS00010	COG0592	DNA-directed DNA polymerase activity
SB21_RS00015	COG2501	S4 domain
SB21_RS00030	COG0187	DNA topoisomerase II activity
SB21_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB21_RS00070	COG0517	IMP dehydrogenase activity
SB21_RS00070	COG0516	GMP reductase activity
SB21_RS00075	COG1686	Belongs to the peptidase S11 family
SB21_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
SB21_RS00105	COG1428	Deoxynucleoside kinase
SB21_RS00110	COG1428	Deoxynucleoside kinase
SB21_RS00115	COG1388	LysM domain
SB21_RS00115	COG3858	chitin binding
SB21_RS00120	COG1335	isochorismatase
SB21_RS00125	COG0590	tRNA wobble adenosine to inosine editing
SB21_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SB21_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SB21_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
SB21_RS00195	COG3853	Toxic anion resistance protein (TelA)
SB21_RS00200	COG1982	Orn Lys Arg decarboxylase major
SB21_RS00210	COG3870	Protein conserved in bacteria
SB21_RS00215	COG1728	Protein conserved in bacteria
SB21_RS00220	COG0470	DNA polymerase III
SB21_RS00225	COG1774	PSP1 C-terminal conserved region
SB21_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SB21_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SB21_RS00250	COG2002	toxin-antitoxin pair type II binding
SB21_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB21_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB21_RS00260	COG0084	hydrolase, TatD family'
SB21_RS00265	COG3584	3D domain protein
SB21_RS00265	COG3583	domain protein
SB21_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SB21_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SB21_RS00285	COG4466	Protein conserved in bacteria
SB21_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB21_RS00305	COG0251	oxidation-reduction process
SB21_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SB21_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SB21_RS00345	COG2002	toxin-antitoxin pair type II binding
SB21_RS00350	COG2244	polysaccharide biosynthetic process
SB21_RS00355	COG3956	TIGRFAM MazG family protein
SB21_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SB21_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SB21_RS00380	COG1098	S1 RNA binding domain
SB21_RS00395	COG2208	phosphoserine phosphatase activity
SB21_RS00400	COG2304	oxidoreductase activity
SB21_RS00405	COG0515	serine threonine protein kinase
SB21_RS00410	COG0037	tRNA processing
SB21_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SB21_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SB21_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB21_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB21_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SB21_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
SB21_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB21_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SB21_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SB21_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SB21_RS00475	COG1396	sequence-specific DNA binding
SB21_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB21_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SB21_RS00565	COG4463	regulation of RNA biosynthetic process
SB21_RS00570	COG3880	PFAM UvrB UvrC protein
SB21_RS00580	COG0542	response to heat
SB21_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SB21_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SB21_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
SB21_RS00615	COG1045	serine acetyltransferase
SB21_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SB21_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB21_RS00635	COG3688	RNA-binding protein containing a PIN domain
SB21_RS00640	COG1595	DNA-templated transcription, initiation
SB21_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB21_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
SB21_RS00680	COG2813	Specifically methylates the guanine in position
SB21_RS00695	COG1358	cellular component organization or biogenesis
SB21_RS00720	COG0596	Alpha beta hydrolase
SB21_RS00830	COG0201	protein transport
SB21_RS00840	COG0024	Methionine aminopeptidase
SB21_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SB21_RS00880	COG1122	ATPase activity
SB21_RS00885	COG1122	ATPase activity
SB21_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB21_RS00910	COG2226	methyltransferase
SB21_RS00915	COG2318	DinB family
SB21_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS00930	COG0489	protein tyrosine kinase activity
SB21_RS00940	COG2194	sulfuric ester hydrolase activity
SB21_RS00945	COG0726	polysaccharide deacetylase
SB21_RS01005	COG0738	Major facilitator superfamily
SB21_RS01020	COG1063	alcohol dehydrogenase
SB21_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
SB21_RS01030	COG0385	Bile acid
SB21_RS01035	COG2819	hydrolase of the alpha beta superfamily
SB21_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB21_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB21_RS01055	COG2207	Transcriptional regulator
SB21_RS01060	COG3876	Protein conserved in bacteria
SB21_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
SB21_RS01075	COG1263	PTS System
SB21_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS01090	COG1683	Conserved Protein
SB21_RS01120	COG1595	DNA-templated transcription, initiation
SB21_RS01125	COG5662	AntiSigma factor
SB21_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB21_RS01135	COG4856	YbbR-like protein
SB21_RS01175	COG1346	cytolysis
SB21_RS01185	COG1846	Transcriptional regulator
SB21_RS01190	COG1113	amino acid transport
SB21_RS01195	COG1011	Hydrolase
SB21_RS01200	COG4585	Histidine kinase
SB21_RS01205	COG2197	response regulator
SB21_RS01210	COG1131	(ABC) transporter
SB21_RS01250	COG0531	amino acid
SB21_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
SB21_RS01275	COG2271	Major facilitator Superfamily
SB21_RS01290	COG2368	4-hydroxyphenylacetate
SB21_RS01300	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS01315	COG0371	Dehydrogenase
SB21_RS01330	COG1183	phosphatidylcholine synthase activity
SB21_RS01335	COG0586	Pfam SNARE associated Golgi protein
SB21_RS01340	COG0688	phosphatidylethanolamine metabolic process
SB21_RS01355	COG1301	dicarboxylic acid transport
SB21_RS01360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB21_RS01365	COG0833	amino acid
SB21_RS01370	COG2040	homocysteine
SB21_RS01375	COG1115	amino acid carrier protein
SB21_RS01380	COG2066	Belongs to the glutaminase family
SB21_RS01385	COG4191	Histidine kinase
SB21_RS01390	COG0784	Response regulator, receiver
SB21_RS01410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB21_RS01415	COG0778	Nitroreductase
SB21_RS01420	COG0346	lactoylglutathione lyase activity
SB21_RS01425	COG2259	Doxx family
SB21_RS01430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS01445	COG3773	Cell wall hydrolase
SB21_RS01455	COG3540	Alkaline phosphatase
SB21_RS01460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB21_RS01465	COG0805	protein transport
SB21_RS01475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB21_RS01480	COG0477	Major facilitator Superfamily
SB21_RS01485	COG1309	transcriptional regulator
SB21_RS01490	COG0252	asparaginase activity
SB21_RS01495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SB21_RS01500	COG1405	negative regulation of cell septum assembly
SB21_RS01500	COG3012	SEC-C Motif Domain Protein
SB21_RS01505	COG0667	Aldo Keto reductase
SB21_RS01515	COG1595	DNA-templated transcription, initiation
SB21_RS01520	COG1595	DNA-templated transcription, initiation
SB21_RS01525	COG1876	peptidase activity
SB21_RS01530	COG0457	Tetratricopeptide repeat
SB21_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS01540	COG0366	Alpha amylase catalytic
SB21_RS01545	COG0803	Belongs to the bacterial solute-binding protein 9 family
SB21_RS01550	COG1121	(ABC) transporter
SB21_RS01555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SB21_RS01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB21_RS01565	COG2310	stress, protein
SB21_RS01570	COG2310	stress, protein
SB21_RS01575	COG2310	stress, protein
SB21_RS01580	COG0861	Integral membrane protein TerC family
SB21_RS01590	COG3853	Toxic anion resistance protein (TelA)
SB21_RS01595	COG0477	Major facilitator Superfamily
SB21_RS01600	COG0517	IMP dehydrogenase activity
SB21_RS01600	COG4175	Glycine betaine
SB21_RS01605	COG4176	ABC-type proline glycine betaine transport system permease component
SB21_RS01610	COG2113	Glycine betaine
SB21_RS01615	COG1473	amidohydrolase
SB21_RS01620	COG1288	antiporter activity
SB21_RS01630	COG0366	Alpha amylase catalytic
SB21_RS01640	COG2814	Major facilitator Superfamily
SB21_RS01645	COG1846	Transcriptional regulator
SB21_RS01650	COG1280	lysine exporter protein (LysE YggA)
SB21_RS01655	COG3403	YqcI/YcgG family
SB21_RS01660	COG1113	amino acid transport
SB21_RS01665	COG3665	Urea carboxylase-associated protein
SB21_RS01685	COG1082	Xylose isomerase domain protein TIM barrel
SB21_RS01690	COG2271	Major facilitator Superfamily
SB21_RS01695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SB21_RS01700	COG3458	cephalosporin-C deacetylase activity
SB21_RS01705	COG3541	Predicted nucleotidyltransferase
SB21_RS01710	COG0506	proline dehydrogenase activity
SB21_RS01715	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS01720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB21_RS01725	COG2508	Transcriptional regulator
SB21_RS01740	COG2146	nitrite reductase [NAD(P)H] activity
SB21_RS01745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SB21_RS01755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SB21_RS01765	COG0523	cobalamin synthesis protein
SB21_RS01770	COG1063	alcohol dehydrogenase
SB21_RS01775	COG1714	RDD family
SB21_RS01785	COG2723	6-phospho-beta-galactosidase activity
SB21_RS01795	COG3209	COG3209 Rhs family protein
SB21_RS01800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB21_RS01805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SB21_RS01810	COG1733	regulation of RNA biosynthetic process
SB21_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS01825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS01830	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SB21_RS01845	COG0697	spore germination
SB21_RS01850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS01860	COG2364	Membrane
SB21_RS01865	COG1126	abc transporter atp-binding protein
SB21_RS01870	COG0765	amino acid transport
SB21_RS01875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS01880	COG0583	DNA-binding transcription factor activity
SB21_RS01885	COG0163	prenyltransferase activity
SB21_RS01890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SB21_RS01905	COG3104	oligopeptide transport
SB21_RS01910	COG5434	Belongs to the glycosyl hydrolase 28 family
SB21_RS01920	COG0697	spore germination
SB21_RS01930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB21_RS01935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB21_RS01940	COG0456	acetyltransferase
SB21_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS01950	COG0765	amino acid transport
SB21_RS01955	COG1126	abc transporter atp-binding protein
SB21_RS01960	COG1473	amidohydrolase
SB21_RS01965	COG2079	MmgE PrpD family protein
SB21_RS01970	COG1136	(ABC) transporter
SB21_RS01975	COG0577	efflux transmembrane transporter activity
SB21_RS01985	COG3850	Histidine kinase
SB21_RS01985	COG5002	protein histidine kinase activity
SB21_RS01990	COG0457	Tetratricopeptide repeat
SB21_RS02005	COG0527	aspartate kinase activity
SB21_RS02010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS02015	COG4605	iron ion homeostasis
SB21_RS02020	COG4604	ABC transporter, ATP-binding protein
SB21_RS02025	COG4607	ABC-type enterochelin transport system periplasmic component
SB21_RS02030	COG2814	Major facilitator Superfamily
SB21_RS02035	COG1309	transcriptional regulator
SB21_RS02040	COG0778	Nitroreductase
SB21_RS02045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SB21_RS02050	COG0640	Transcriptional regulator
SB21_RS02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS02060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SB21_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS02070	COG4975	Glucose uptake
SB21_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS02080	COG4549	nuclear export factor GLE1
SB21_RS02085	COG1276	copper resistance
SB21_RS02085	COG2372	response to copper ion
SB21_RS02090	COG1349	DNA-binding transcription factor activity
SB21_RS02100	COG2213	PTS system mannitol-specific
SB21_RS02105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS02115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SB21_RS02125	COG0561	phosphatase activity
SB21_RS02135	COG1914	H( )-stimulated, divalent metal cation uptake system
SB21_RS02145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SB21_RS02150	COG1984	allophanate hydrolase subunit 2
SB21_RS02155	COG1414	Transcriptional regulator
SB21_RS02160	COG2755	lipolytic protein G-D-S-L family
SB21_RS02170	COG2329	Antibiotic biosynthesis monooxygenase
SB21_RS02175	COG0768	penicillin binding
SB21_RS02180	COG4989	oxidoreductase activity
SB21_RS02185	COG3711	transcriptional antiterminator
SB21_RS02190	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS02200	COG1917	Cupin 2, conserved barrel domain protein
SB21_RS02205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS02210	COG3871	stress protein (general stress protein 26)
SB21_RS02225	COG2814	Major facilitator Superfamily
SB21_RS02230	COG1522	sequence-specific DNA binding
SB21_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB21_RS02235	COG0551	DNA topoisomerase type I activity
SB21_RS02245	COG3706	GGDEF domain
SB21_RS02250	COG5298	Protein conserved in bacteria
SB21_RS02265	COG0531	amino acid
SB21_RS02270	COG0494	nUDIX hydrolase
SB21_RS02275	COG0028	Belongs to the TPP enzyme family
SB21_RS02300	COG0457	Tetratricopeptide repeat
SB21_RS02330	COG1914	H( )-stimulated, divalent metal cation uptake system
SB21_RS02345	COG4876	unkown
SB21_RS02355	COG2076	Multidrug Resistance protein
SB21_RS02360	COG2217	Heavy metal translocating P-type atpase
SB21_RS02365	COG3729	General stress protein
SB21_RS02370	COG0662	Cupin 2, conserved barrel domain protein
SB21_RS02375	COG2329	Antibiotic biosynthesis monooxygenase
SB21_RS02380	COG3546	catalase activity
SB21_RS02385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SB21_RS02390	COG3290	protein histidine kinase activity
SB21_RS02395	COG4565	transcriptional regulatory protein
SB21_RS02400	COG1301	dicarboxylic acid transport
SB21_RS02405	COG0628	permease
SB21_RS02410	COG1131	(ABC) transporter
SB21_RS02415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB21_RS02425	COG1960	acyl-CoA dehydrogenase activity
SB21_RS02440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB21_RS02445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS02455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SB21_RS02460	COG0513	Belongs to the DEAD box helicase family
SB21_RS02465	COG3402	PFAM membrane-flanked domain
SB21_RS02470	COG3428	Bacterial PH domain
SB21_RS02475	COG0705	Rhomboid family
SB21_RS02485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SB21_RS02490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SB21_RS02495	COG0864	Transcriptional regulator
SB21_RS02500	COG2337	Toxic component of a toxin-antitoxin (TA) module
SB21_RS02505	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS02510	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS02515	COG2172	sigma factor antagonist activity
SB21_RS02520	COG2208	phosphoserine phosphatase activity
SB21_RS02525	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS02535	COG1191	sigma factor activity
SB21_RS02540	COG2208	phosphoserine phosphatase activity
SB21_RS02545	COG2183	response to ionizing radiation
SB21_RS02595	COG0582	viral genome integration into host DNA
SB21_RS02600	COG2856	Zn peptidase
SB21_RS02605	COG1396	sequence-specific DNA binding
SB21_RS02630	COG1674	ftsk spoiiie
SB21_RS02635	COG2946	Replication initiation factor
SB21_RS02685	COG0433	COG0433 Predicted ATPase
SB21_RS02695	COG5644	endopeptidase inhibitor activity
SB21_RS02700	COG0791	NLP P60 protein
SB21_RS02700	COG0741	lytic transglycosylase activity
SB21_RS02720	COG0457	Tetratricopeptide repeat
SB21_RS02745	COG1959	2 iron, 2 sulfur cluster binding
SB21_RS02750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SB21_RS02760	COG0457	Tetratricopeptide repeat
SB21_RS02765	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB21_RS02780	COG0477	Major facilitator Superfamily
SB21_RS02785	COG1846	Transcriptional regulator
SB21_RS02795	COG2030	dehydratase
SB21_RS02810	COG1959	2 iron, 2 sulfur cluster binding
SB21_RS02815	COG2910	NAD(P)H-binding
SB21_RS02820	COG1309	transcriptional regulator
SB21_RS02825	COG0300	oxidoreductase activity
SB21_RS02835	COG3239	Fatty acid desaturase
SB21_RS02845	COG1278	Cold shock
SB21_RS02850	COG1329	Transcriptional regulator
SB21_RS02855	COG1794	racemase activity, acting on amino acids and derivatives
SB21_RS02870	COG1846	Transcriptional regulator
SB21_RS02870	COG0456	acetyltransferase
SB21_RS02875	COG2271	Major facilitator Superfamily
SB21_RS02880	COG3621	Patatin-like phospholipase
SB21_RS02890	COG0662	Cupin 2, conserved barrel domain protein
SB21_RS02905	COG0277	FAD linked oxidase domain protein
SB21_RS02930	COG0662	Cupin 2, conserved barrel domain protein
SB21_RS02940	COG2318	DinB family
SB21_RS02945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SB21_RS02980	COG0351	phosphomethylpyrimidine kinase
SB21_RS02995	COG1064	alcohol dehydrogenase
SB21_RS03000	COG0789	Transcriptional regulator
SB21_RS03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS03045	COG2814	Major facilitator Superfamily
SB21_RS03050	COG1309	transcriptional regulator
SB21_RS03055	COG0697	spore germination
SB21_RS03060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS03065	COG5577	PFAM Coat F domain
SB21_RS03075	COG1063	alcohol dehydrogenase
SB21_RS03080	COG5577	PFAM Coat F domain
SB21_RS03095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SB21_RS03100	COG0488	(ABC) transporter
SB21_RS03105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS03110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS03120	COG2814	Major facilitator Superfamily
SB21_RS03125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB21_RS03135	COG0730	response to heat
SB21_RS03140	COG0456	acetyltransferase
SB21_RS03145	COG0789	Transcriptional regulator
SB21_RS03145	COG4978	Transcriptional regulator
SB21_RS03150	COG0697	spore germination
SB21_RS03155	COG1051	belongs to the nudix hydrolase family
SB21_RS03160	COG2226	methyltransferase
SB21_RS03170	COG1802	Transcriptional regulator
SB21_RS03175	COG1819	glycosyl
SB21_RS03190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB21_RS03195	COG1388	LysM domain
SB21_RS03200	COG2814	Major facilitator Superfamily
SB21_RS03205	COG2188	Transcriptional regulator
SB21_RS03215	COG2807	transmembrane transport
SB21_RS03220	COG2076	Multidrug Resistance protein
SB21_RS03225	COG2076	Multidrug Resistance protein
SB21_RS03230	COG1309	transcriptional regulator
SB21_RS03235	COG0531	amino acid
SB21_RS03245	COG3832	glyoxalase III activity
SB21_RS03250	COG0604	alcohol dehydrogenase
SB21_RS03255	COG2814	Major facilitator Superfamily
SB21_RS03295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SB21_RS03300	COG0802	atpase or kinase
SB21_RS03305	COG1214	PFAM Peptidase M22, glycoprotease
SB21_RS03310	COG0456	acetyltransferase
SB21_RS03315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SB21_RS03320	COG0488	(ABC) transporter
SB21_RS03335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB21_RS03340	COG0805	protein transport
SB21_RS03350	COG1266	CAAX protease self-immunity
SB21_RS03375	COG0457	Tetratricopeptide repeat
SB21_RS03380	COG1063	alcohol dehydrogenase
SB21_RS03385	COG2211	Major facilitator Superfamily
SB21_RS03390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB21_RS03400	COG1842	Phage shock protein A
SB21_RS03405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB21_RS03410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SB21_RS03415	COG4260	virion core protein, lumpy skin disease virus
SB21_RS03420	COG2755	lipolytic protein G-D-S-L family
SB21_RS03420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SB21_RS03430	COG1595	DNA-templated transcription, initiation
SB21_RS03435	COG1063	alcohol dehydrogenase
SB21_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SB21_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
SB21_RS03460	COG1113	amino acid transport
SB21_RS03465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB21_RS03470	COG0714	Associated with various cellular activities
SB21_RS03475	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
SB21_RS03480	COG1305	Transglutaminase-like
SB21_RS03505	COG2252	PERMEase
SB21_RS03510	COG3064	Membrane
SB21_RS03530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SB21_RS03535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SB21_RS03540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SB21_RS03545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SB21_RS03550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB21_RS03565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SB21_RS03575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SB21_RS03580	COG0138	bifunctional purine biosynthesis protein purh
SB21_RS03585	COG0151	Belongs to the GarS family
SB21_RS03595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SB21_RS03600	COG1470	cell adhesion involved in biofilm formation
SB21_RS03605	COG4496	protein, YerC YecD
SB21_RS03610	COG0069	glutamate synthase activity
SB21_RS03620	COG0210	DNA helicase
SB21_RS03630	COG4851	CamS sex pheromone cAM373 precursor
SB21_RS03635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB21_RS03640	COG1285	pathogenesis
SB21_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB21_RS03665	COG1309	transcriptional regulator
SB21_RS03670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SB21_RS03675	COG1597	lipid kinase activity
SB21_RS03680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB21_RS03690	COG1131	(ABC) transporter
SB21_RS03730	COG5444	nuclease activity
SB21_RS03760	COG3546	catalase activity
SB21_RS03765	COG0454	-acetyltransferase
SB21_RS03775	COG2323	membrane
SB21_RS03780	COG2329	Antibiotic biosynthesis monooxygenase
SB21_RS03785	COG0346	lactoylglutathione lyase activity
SB21_RS03795	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS03800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SB21_RS03805	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SB21_RS03810	COG4208	sulfate ABC transporter
SB21_RS03820	COG5583	Uncharacterized small protein (DUF2292)
SB21_RS03825	COG0196	riboflavin kinase activity
SB21_RS03830	COG0670	Belongs to the BI1 family
SB21_RS03840	COG1846	Transcriptional regulator
SB21_RS03845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SB21_RS03855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB21_RS03855	COG2124	cytochrome p450
SB21_RS03860	COG1368	sulfuric ester hydrolase activity
SB21_RS03865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SB21_RS03870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS03875	COG1442	glycosyl transferase family 8
SB21_RS03880	COG1216	Glycosyl transferase, family 2
SB21_RS03885	COG1442	glycosyl transferase family 8
SB21_RS03890	COG2223	nitrite transmembrane transporter activity
SB21_RS03895	COG0531	amino acid
SB21_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS03905	COG0840	transmembrane signaling receptor activity
SB21_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS03915	COG0457	Tetratricopeptide repeat
SB21_RS03915	COG0463	Glycosyl transferase, family 2
SB21_RS03920	COG0488	(ABC) transporter
SB21_RS03925	COG0789	Transcriptional regulator
SB21_RS03930	COG2814	Major facilitator Superfamily
SB21_RS03935	COG0488	(ABC) transporter
SB21_RS03940	COG0513	Belongs to the DEAD box helicase family
SB21_RS03945	COG0456	acetyltransferase
SB21_RS03950	COG2130	NADP-dependent
SB21_RS03965	COG3866	Pectate lyase
SB21_RS03970	COG0471	metal ion transport
SB21_RS04000	COG4565	transcriptional regulatory protein
SB21_RS04005	COG3181	Tripartite tricarboxylate transporter family receptor
SB21_RS04010	COG2851	Citrate transporter
SB21_RS04015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB21_RS04020	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SB21_RS04030	COG2258	MOSC domain
SB21_RS04050	COG0024	Methionine aminopeptidase
SB21_RS04055	COG1263	PTS System
SB21_RS04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS04065	COG1368	sulfuric ester hydrolase activity
SB21_RS04075	COG0071	Belongs to the small heat shock protein (HSP20) family
SB21_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS04090	COG1263	PTS System
SB21_RS04100	COG2188	Transcriptional regulator
SB21_RS04105	COG0778	Nitroreductase
SB21_RS04120	COG0737	Belongs to the 5'-nucleotidase family
SB21_RS04125	COG0693	protein deglycase activity
SB21_RS04130	COG1609	Transcriptional regulator
SB21_RS04145	COG2814	Major facilitator Superfamily
SB21_RS04155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SB21_RS04160	COG4980	gas vesicle protein
SB21_RS04165	COG1295	ribonuclease BN
SB21_RS04170	COG0477	Major facilitator Superfamily
SB21_RS04175	COG0387	Pfam Sodium calcium exchanger
SB21_RS04185	COG0668	transmembrane transport
SB21_RS04190	COG0535	radical SAM domain protein
SB21_RS04200	COG0726	polysaccharide deacetylase
SB21_RS04205	COG2084	Dehydrogenase
SB21_RS04215	COG0598	Magnesium transport protein CorA
SB21_RS04220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SB21_RS04225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB21_RS04235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB21_RS04245	COG4637	Psort location Cytoplasmic, score
SB21_RS04250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB21_RS04255	COG0022	dehydrogenase e1 component
SB21_RS04260	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB21_RS04265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB21_RS04270	COG3284	Transcriptional regulator
SB21_RS04280	COG1486	melibiose metabolic process
SB21_RS04285	COG1737	Transcriptional regulator
SB21_RS04290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS04290	COG1263	PTS System
SB21_RS04295	COG1132	(ABC) transporter
SB21_RS04300	COG1132	(ABC) transporter
SB21_RS04305	COG2259	Doxx family
SB21_RS04310	COG2514	catechol 2,3-dioxygenase activity
SB21_RS04315	COG4977	sequence-specific DNA binding
SB21_RS04315	COG1917	Cupin 2, conserved barrel domain protein
SB21_RS04320	COG2814	Major facilitator Superfamily
SB21_RS04325	COG1082	Xylose isomerase domain protein TIM barrel
SB21_RS04330	COG0673	inositol 2-dehydrogenase activity
SB21_RS04340	COG1695	Transcriptional regulator
SB21_RS04345	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB21_RS04350	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SB21_RS04355	COG3848	Pyruvate phosphate dikinase
SB21_RS04355	COG0574	Belongs to the PEP-utilizing enzyme family
SB21_RS04360	COG2732	(Barnase) inhibitor
SB21_RS04370	COG2814	Major facilitator Superfamily
SB21_RS04375	COG1846	Transcriptional regulator
SB21_RS04380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SB21_RS04380	COG0392	lysyltransferase activity
SB21_RS04385	COG0384	phenazine biosynthesis protein PhzF
SB21_RS04390	COG0778	Nitroreductase
SB21_RS04405	COG1090	epimerase
SB21_RS04420	COG2814	Major facilitator Superfamily
SB21_RS04430	COG3591	Belongs to the peptidase S1B family
SB21_RS04445	COG3103	Sh3 type 3 domain protein
SB21_RS04450	COG5658	integral membrane protein
SB21_RS04455	COG0596	Alpha beta hydrolase
SB21_RS04460	COG0463	Glycosyl transferase, family 2
SB21_RS04465	COG4485	Bacterial membrane protein, YfhO
SB21_RS04470	COG1988	membrane-bound metal-dependent
SB21_RS04475	COG1194	a g-specific adenine glycosylase
SB21_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS04505	COG1132	(ABC) transporter
SB21_RS04510	COG4129	membrane
SB21_RS04520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SB21_RS04525	COG0735	belongs to the Fur family
SB21_RS04635	COG1757	Na H antiporter
SB21_RS04640	COG3340	Belongs to the peptidase S51 family
SB21_RS04660	COG0747	negative chemotaxis
SB21_RS04665	COG0601	transmembrane transport
SB21_RS04670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB21_RS04675	COG0444	Belongs to the ABC transporter superfamily
SB21_RS04680	COG4608	Belongs to the ABC transporter superfamily
SB21_RS04685	COG0753	catalase activity
SB21_RS04700	COG1116	anion transmembrane transporter activity
SB21_RS04705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB21_RS04710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB21_RS04730	COG1476	TRANSCRIPTIONal
SB21_RS04740	COG3382	B3 4 domain protein
SB21_RS04745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SB21_RS04755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SB21_RS04760	COG0789	Transcriptional regulator
SB21_RS04765	COG1664	Polymer-forming cytoskeletal
SB21_RS04770	COG1664	Polymer-forming cytoskeletal
SB21_RS04775	COG2766	serine protein kinase
SB21_RS04790	COG1846	Transcriptional regulator
SB21_RS04795	COG1566	PFAM secretion protein HlyD family protein
SB21_RS04800	COG2814	Major facilitator Superfamily
SB21_RS04805	COG0655	NAD(P)H dehydrogenase (quinone) activity
SB21_RS04820	COG1725	Transcriptional regulator
SB21_RS04825	COG1131	(ABC) transporter
SB21_RS04830	COG1131	(ABC) transporter
SB21_RS04835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB21_RS04840	COG1278	Cold shock
SB21_RS04850	COG1464	Belongs to the NlpA lipoprotein family
SB21_RS04855	COG3706	GGDEF domain
SB21_RS04860	COG1823	symporter activity
SB21_RS04880	COG5577	PFAM Coat F domain
SB21_RS04885	COG4085	toxin activity
SB21_RS04885	COG1525	nuclease
SB21_RS04885	COG0737	Belongs to the 5'-nucleotidase family
SB21_RS04890	COG3764	Sortase (surface protein transpeptidase)
SB21_RS04895	COG0564	pseudouridine synthase activity
SB21_RS04905	COG0517	IMP dehydrogenase activity
SB21_RS04910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB21_RS04915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB21_RS04915	COG3153	acetyltransferase
SB21_RS04920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB21_RS04925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB21_RS04930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SB21_RS04940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SB21_RS04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB21_RS04950	COG4585	Histidine kinase
SB21_RS04950	COG2203	Gaf domain
SB21_RS04960	COG0431	NADPH-dependent FMN reductase
SB21_RS04975	COG0791	NLP P60 protein
SB21_RS04975	COG1388	LysM domain
SB21_RS04980	COG1959	2 iron, 2 sulfur cluster binding
SB21_RS04985	COG0668	transmembrane transport
SB21_RS04990	COG2719	SpoVR family
SB21_RS04995	COG1785	Belongs to the alkaline phosphatase family
SB21_RS05000	COG0791	NLP P60 protein
SB21_RS05000	COG1388	LysM domain
SB21_RS05005	COG0583	DNA-binding transcription factor activity
SB21_RS05010	COG0372	Belongs to the citrate synthase family
SB21_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS05020	COG0531	amino acid
SB21_RS05025	COG0733	neurotransmitter:sodium symporter activity
SB21_RS05040	COG1595	DNA-templated transcription, initiation
SB21_RS05045	COG0204	Acyl-transferase
SB21_RS05050	COG1253	flavin adenine dinucleotide binding
SB21_RS05055	COG0789	Transcriptional regulator
SB21_RS05060	COG0436	Aminotransferase
SB21_RS05065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB21_RS05070	COG1253	flavin adenine dinucleotide binding
SB21_RS05075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SB21_RS05080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SB21_RS05085	COG0584	glycerophosphoryl diester phosphodiesterase
SB21_RS05095	COG0668	transmembrane transport
SB21_RS05100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SB21_RS05105	COG0726	polysaccharide deacetylase
SB21_RS05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB21_RS05115	COG3226	Transcriptional regulator
SB21_RS05125	COG0589	response to stress
SB21_RS05130	COG1132	(ABC) transporter
SB21_RS05135	COG1132	(ABC) transporter
SB21_RS05140	COG0702	epimerase
SB21_RS05160	COG0189	ligase activity
SB21_RS05165	COG0189	ligase activity
SB21_RS05180	COG4335	DNA alkylation repair
SB21_RS05185	COG0561	phosphatase activity
SB21_RS05190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB21_RS05200	COG0475	glutathione-regulated potassium exporter activity
SB21_RS05205	COG0490	domain, Protein
SB21_RS05215	COG1024	Enoyl-CoA hydratase
SB21_RS05225	COG4152	abc transporter atp-binding protein
SB21_RS05230	COG1668	transmembrane transport
SB21_RS05235	COG0420	3'-5' exonuclease activity
SB21_RS05240	COG4717	serine-type aminopeptidase activity
SB21_RS05255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB21_RS05295	COG4980	gas vesicle protein
SB21_RS05310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SB21_RS05315	COG0537	adenosine 5'-monophosphoramidase activity
SB21_RS05320	COG1131	(ABC) transporter
SB21_RS05325	COG4473	ABC transporter
SB21_RS05335	COG1473	amidohydrolase
SB21_RS05345	COG2329	Antibiotic biosynthesis monooxygenase
SB21_RS05350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB21_RS05360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SB21_RS05370	COG1309	transcriptional regulator
SB21_RS05375	COG1511	domain protein
SB21_RS05380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB21_RS05390	COG1363	Peptidase, m42
SB21_RS05395	COG1301	dicarboxylic acid transport
SB21_RS05405	COG1234	tRNA 3'-trailer cleavage
SB21_RS05410	COG0095	Lipoate-protein ligase
SB21_RS05415	COG0702	epimerase
SB21_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS05430	COG0501	Belongs to the peptidase M48B family
SB21_RS05435	COG1404	Belongs to the peptidase S8 family
SB21_RS05450	COG0406	alpha-ribazole phosphatase activity
SB21_RS05455	COG0183	Belongs to the thiolase family
SB21_RS05465	COG1268	BioY protein
SB21_RS05470	COG0840	transmembrane signaling receptor activity
SB21_RS05475	COG0723	plastoquinol--plastocyanin reductase activity
SB21_RS05475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB21_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS05490	COG4903	ComK protein
SB21_RS05500	COG5646	InterPro IPR014922
SB21_RS05530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB21_RS05545	COG0398	Pfam SNARE associated Golgi protein
SB21_RS05550	COG0681	Belongs to the peptidase S26 family
SB21_RS05555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SB21_RS05560	COG1846	Transcriptional regulator
SB21_RS05565	COG3180	Ammonia monooxygenase
SB21_RS05570	COG2814	Major facilitator Superfamily
SB21_RS05580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SB21_RS05605	COG0420	3'-5' exonuclease activity
SB21_RS05610	COG0419	ATPase involved in DNA repair
SB21_RS05615	COG1403	HNH endonuclease
SB21_RS05655	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB21_RS05675	COG0367	asparagine synthase
SB21_RS05680	COG1562	ergosterol biosynthetic process
SB21_RS05685	COG0534	Mate efflux family protein
SB21_RS05690	COG1917	Cupin 2, conserved barrel domain protein
SB21_RS05690	COG2207	Transcriptional regulator
SB21_RS05695	COG2318	DinB family
SB21_RS05705	COG1357	PFAM Pentapeptide repeats (8 copies)
SB21_RS05710	COG2153	protein acetylation
SB21_RS05715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SB21_RS05715	COG0646	methionine synthase
SB21_RS05725	COG2996	Protein conserved in bacteria
SB21_RS05730	COG1744	ABC transporter substrate-binding protein PnrA-like
SB21_RS05735	COG0840	transmembrane signaling receptor activity
SB21_RS05740	COG2124	cytochrome p450
SB21_RS05750	COG1307	EDD domain protein, DegV family
SB21_RS05755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS05770	COG0561	phosphatase activity
SB21_RS05775	COG1073	alpha beta
SB21_RS05780	COG2151	metal-sulfur cluster biosynthetic enzyme
SB21_RS05790	COG0277	FAD linked oxidase domain protein
SB21_RS05795	COG2271	Major facilitator Superfamily
SB21_RS05805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SB21_RS05815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB21_RS05820	COG0505	Belongs to the CarA family
SB21_RS05825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB21_RS05850	COG2267	carboxylic ester hydrolase activity
SB21_RS05860	COG1744	ABC transporter substrate-binding protein PnrA-like
SB21_RS05875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB21_RS05880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB21_RS05885	COG5504	Zn-dependent protease
SB21_RS05890	COG0444	Belongs to the ABC transporter superfamily
SB21_RS05895	COG4608	Belongs to the ABC transporter superfamily
SB21_RS05905	COG0601	transmembrane transport
SB21_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB21_RS05920	COG2814	Major facilitator Superfamily
SB21_RS05930	COG0180	Tryptophanyl-tRNA synthetase
SB21_RS05935	COG4166	transmembrane transport
SB21_RS05940	COG0601	transmembrane transport
SB21_RS05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB21_RS05950	COG0444	Belongs to the ABC transporter superfamily
SB21_RS05955	COG4608	Belongs to the ABC transporter superfamily
SB21_RS05965	COG0456	acetyltransferase
SB21_RS05970	COG1393	Belongs to the ArsC family
SB21_RS05975	COG0861	Integral membrane protein TerC family
SB21_RS05980	COG4862	establishment of competence for transformation
SB21_RS05985	COG4469	Competence protein
SB21_RS05990	COG1164	Oligoendopeptidase f
SB21_RS06000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB21_RS06005	COG2346	COG2346, Truncated hemoglobins
SB21_RS06010	COG0741	lytic transglycosylase activity
SB21_RS06015	COG4116	CYTH
SB21_RS06025	COG2357	RelA SpoT domain protein
SB21_RS06030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SB21_RS06035	COG0564	pseudouridine synthase activity
SB21_RS06050	COG0569	domain protein
SB21_RS06050	COG0475	glutathione-regulated potassium exporter activity
SB21_RS06055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SB21_RS06060	COG0352	thiamine-phosphate diphosphorylase activity
SB21_RS06065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB21_RS06070	COG2104	thiamine diphosphate biosynthetic process
SB21_RS06080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB21_RS06085	COG0351	phosphomethylpyrimidine kinase
SB21_RS06090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SB21_RS06145	COG0210	DNA helicase
SB21_RS06165	COG1131	(ABC) transporter
SB21_RS06175	COG2153	protein acetylation
SB21_RS06185	COG2382	esterase
SB21_RS06190	COG0626	cystathionine gamma-synthase activity
SB21_RS06195	COG0626	cystathionine gamma-synthase activity
SB21_RS06235	COG5444	nuclease activity
SB21_RS06250	COG2367	Beta-lactamase
SB21_RS06255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SB21_RS06260	COG2814	Major facilitator Superfamily
SB21_RS06265	COG1846	Transcriptional regulator
SB21_RS06275	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB21_RS06280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB21_RS06285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SB21_RS06290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS06290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS06295	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB21_RS06330	COG1285	pathogenesis
SB21_RS06345	COG2205	protein histidine kinase activity
SB21_RS06355	COG3383	formate dehydrogenase (NAD+) activity
SB21_RS06360	COG2427	Protein of unknown function (DUF1641)
SB21_RS06365	COG2124	cytochrome p450
SB21_RS06370	COG1819	glycosyl
SB21_RS06380	COG1587	Uroporphyrinogen-III synthase
SB21_RS06385	COG0390	transport system, permease component
SB21_RS06390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB21_RS06395	COG0697	spore germination
SB21_RS06400	COG4297	protein containing double-stranded beta helix domain
SB21_RS06410	COG1252	NADH dehydrogenase
SB21_RS06420	COG2211	Major facilitator Superfamily
SB21_RS06425	COG1609	Transcriptional regulator
SB21_RS06430	COG0246	Mannitol dehydrogenase
SB21_RS06435	COG2721	sulfolactate sulfo-lyase activity
SB21_RS06440	COG0730	response to heat
SB21_RS06445	COG2318	DinB family
SB21_RS06450	COG0457	Tetratricopeptide repeat
SB21_RS06460	COG5632	N-Acetylmuramoyl-L-alanine amidase
SB21_RS06460	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS06460	COG1388	LysM domain
SB21_RS06470	COG4195	phage-related replication protein
SB21_RS06475	COG2856	Zn peptidase
SB21_RS06480	COG1396	sequence-specific DNA binding
SB21_RS06490	COG1522	sequence-specific DNA binding
SB21_RS06495	COG1484	DNA-dependent DNA replication
SB21_RS06510	COG1595	DNA-templated transcription, initiation
SB21_RS06515	COG3728	DNA packaging
SB21_RS06515	COG5484	DNA packaging
SB21_RS06525	COG5518	Phage portal protein
SB21_RS06530	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SB21_RS06535	COG4653	Phage capsid family
SB21_RS06585	COG5412	phage tail tape measure protein
SB21_RS06585	COG3953	SLT domain
SB21_RS06585	COG3953	SLT domain
SB21_RS06585	COG5412	phage tail tape measure protein
SB21_RS06585	COG3953	SLT domain
SB21_RS06585	COG5412	phage tail tape measure protein
SB21_RS06590	COG1652	LysM domain
SB21_RS06595	COG4193	domain, Protein
SB21_RS06605	COG3628	GPW Gp25 family protein
SB21_RS06610	COG3299	homolog of phage Mu protein gp47
SB21_RS06615	COG3778	Protein conserved in bacteria
SB21_RS06655	COG5632	N-Acetylmuramoyl-L-alanine amidase
SB21_RS06655	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS06670	COG0306	phosphate transporter
SB21_RS06675	COG1392	Phosphate transport regulator
SB21_RS06680	COG0531	amino acid
SB21_RS06685	COG0346	lactoylglutathione lyase activity
SB21_RS06690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SB21_RS06695	COG0463	Glycosyl transferase, family 2
SB21_RS06700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB21_RS06705	COG0477	Major facilitator Superfamily
SB21_RS06715	COG0601	transmembrane transport
SB21_RS06720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB21_RS06725	COG0444	Belongs to the ABC transporter superfamily
SB21_RS06730	COG4166	transmembrane transport
SB21_RS06735	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB21_RS06740	COG4948	Mandelate Racemase Muconate Lactonizing
SB21_RS06745	COG0791	NLP P60 protein
SB21_RS06750	COG4608	Belongs to the ABC transporter superfamily
SB21_RS06755	COG2706	6-phosphogluconolactonase activity
SB21_RS06760	COG1834	amidinotransferase
SB21_RS06765	COG1607	acyl-coa hydrolase
SB21_RS06770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS06775	COG2076	Multidrug Resistance protein
SB21_RS06780	COG2076	Multidrug Resistance protein
SB21_RS06785	COG0788	formyltetrahydrofolate deformylase activity
SB21_RS06790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB21_RS06800	COG1764	response to oxidative stress
SB21_RS06805	COG1846	Transcriptional regulator
SB21_RS06810	COG1764	response to oxidative stress
SB21_RS06825	COG0457	Tetratricopeptide repeat
SB21_RS06825	COG0463	Glycosyl transferase, family 2
SB21_RS06835	COG2814	Major facilitator Superfamily
SB21_RS06840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB21_RS06850	COG1404	Belongs to the peptidase S8 family
SB21_RS06855	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS06860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB21_RS06865	COG1122	ATPase activity
SB21_RS06870	COG4721	ABC-type cobalt transport system, permease component
SB21_RS06875	COG3858	chitin binding
SB21_RS06875	COG1388	LysM domain
SB21_RS06895	COG2239	Acts as a magnesium transporter
SB21_RS06900	COG0789	Transcriptional regulator
SB21_RS06915	COG1846	Transcriptional regulator
SB21_RS06920	COG0726	polysaccharide deacetylase
SB21_RS06925	COG1793	dna ligase
SB21_RS06925	COG3285	dna ligase
SB21_RS06930	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SB21_RS06935	COG0586	Pfam SNARE associated Golgi protein
SB21_RS06940	COG0861	Integral membrane protein TerC family
SB21_RS06945	COG1191	sigma factor activity
SB21_RS06970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SB21_RS06985	COG3594	Acyltransferase
SB21_RS06990	COG5002	protein histidine kinase activity
SB21_RS06995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB21_RS07010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB21_RS07015	COG0436	Aminotransferase
SB21_RS07045	COG3852	Histidine kinase
SB21_RS07050	COG1846	Transcriptional regulator
SB21_RS07055	COG1360	Flagellar Motor Protein
SB21_RS07060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB21_RS07065	COG0542	response to heat
SB21_RS07075	COG3949	Membrane
SB21_RS07090	COG0720	synthase
SB21_RS07095	COG0602	queuosine metabolic process
SB21_RS07105	COG1733	regulation of RNA biosynthetic process
SB21_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS07120	COG1388	LysM domain
SB21_RS07120	COG4641	Protein conserved in bacteria
SB21_RS07125	COG1388	LysM domain
SB21_RS07130	COG3858	chitin binding
SB21_RS07140	COG4873	Protein conserved in bacteria
SB21_RS07150	COG3773	Cell wall hydrolase
SB21_RS07155	COG2244	polysaccharide biosynthetic process
SB21_RS07160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS07165	COG2217	Heavy metal translocating P-type atpase
SB21_RS07170	COG0006	proline dipeptidase activity
SB21_RS07175	COG1609	Transcriptional regulator
SB21_RS07180	COG3711	transcriptional antiterminator
SB21_RS07185	COG1263	PTS System
SB21_RS07185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS07185	COG2190	(PTS) system
SB21_RS07190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS07195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SB21_RS07205	COG1533	DNA photolyase activity
SB21_RS07210	COG0840	transmembrane signaling receptor activity
SB21_RS07215	COG2084	Dehydrogenase
SB21_RS07220	COG2340	Cysteine-rich secretory protein family
SB21_RS07225	COG0768	penicillin binding
SB21_RS07230	COG4191	Histidine kinase
SB21_RS07235	COG0436	Aminotransferase
SB21_RS07245	COG0835	chemotaxis
SB21_RS07245	COG0784	Response regulator, receiver
SB21_RS07255	COG2814	Major facilitator Superfamily
SB21_RS07260	COG1376	ErfK ybiS ycfS ynhG family protein
SB21_RS07265	COG1408	metallophosphoesterase
SB21_RS07280	COG2200	EAL domain
SB21_RS07285	COG4703	Protein of unknown function (DUF1797)
SB21_RS07290	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SB21_RS07300	COG0517	IMP dehydrogenase activity
SB21_RS07305	COG0583	DNA-binding transcription factor activity
SB21_RS07310	COG0716	FMN binding
SB21_RS07320	COG0716	FMN binding
SB21_RS07340	COG0668	transmembrane transport
SB21_RS07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS07365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB21_RS07370	COG0303	'Molybdopterin
SB21_RS07375	COG1763	Mo-molybdopterin cofactor biosynthetic process
SB21_RS07380	COG0314	molybdopterin synthase activity
SB21_RS07385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SB21_RS07395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SB21_RS07400	COG1136	(ABC) transporter
SB21_RS07405	COG0577	efflux transmembrane transporter activity
SB21_RS07410	COG1349	DNA-binding transcription factor activity
SB21_RS07415	COG1105	Belongs to the carbohydrate kinase PfkB family
SB21_RS07420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB21_RS07420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB21_RS07420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS07425	COG0681	Belongs to the peptidase S26 family
SB21_RS07435	COG0488	(ABC) transporter
SB21_RS07440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB21_RS07445	COG2309	aminopeptidase activity
SB21_RS07455	COG1077	Cell shape determining protein MreB Mrl
SB21_RS07465	COG2002	toxin-antitoxin pair type II binding
SB21_RS07470	COG3852	Histidine kinase
SB21_RS07475	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SB21_RS07475	COG2105	PFAM AIG2 family protein
SB21_RS07480	COG0569	domain protein
SB21_RS07490	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB21_RS07500	COG0561	phosphatase activity
SB21_RS07505	COG0242	peptide deformylase activity
SB21_RS07515	COG0497	DNA recombination
SB21_RS07535	COG3321	synthase
SB21_RS07535	COG4221	oxidoreductase activity
SB21_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS07535	COG0300	oxidoreductase activity
SB21_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS07540	COG3321	synthase
SB21_RS07540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS07540	COG4221	oxidoreductase activity
SB21_RS07545	COG0300	oxidoreductase activity
SB21_RS07545	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS07545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS07545	COG3321	synthase
SB21_RS07550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS07550	COG0300	oxidoreductase activity
SB21_RS07550	COG4221	oxidoreductase activity
SB21_RS07550	COG3321	synthase
SB21_RS07555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS07555	COG4221	oxidoreductase activity
SB21_RS07555	COG3321	synthase
SB21_RS07555	COG0300	oxidoreductase activity
SB21_RS07565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB21_RS07570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB21_RS07575	COG0022	dehydrogenase e1 component
SB21_RS07580	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB21_RS07585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB21_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS07605	COG1982	Orn Lys Arg decarboxylase major
SB21_RS07630	COG0483	inositol monophosphate 1-phosphatase activity
SB21_RS07640	COG3227	Zinc metalloprotease (Elastase)
SB21_RS07645	COG1595	DNA-templated transcription, initiation
SB21_RS07665	COG1217	gtp-binding protein TYPA
SB21_RS07675	COG4896	Protein conserved in bacteria
SB21_RS07685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SB21_RS07690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB21_RS07695	COG2066	Belongs to the glutaminase family
SB21_RS07705	COG0772	Belongs to the SEDS family
SB21_RS07710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SB21_RS07725	COG2010	Cytochrome c
SB21_RS07725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB21_RS07735	COG1845	cytochrome c oxidase, subunit III
SB21_RS07740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB21_RS07745	COG3336	cytochrome c oxidase
SB21_RS07755	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SB21_RS07760	COG2340	Cysteine-rich secretory protein family
SB21_RS07775	COG3679	Belongs to the UPF0342 family
SB21_RS07790	COG0742	ribosomal rna small subunit methyltransferase
SB21_RS07800	COG3314	Sporulation integral membrane protein YlbJ
SB21_RS07805	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB21_RS07810	COG3480	Lon protease (S16) C-terminal proteolytic domain
SB21_RS07820	COG1399	metal-binding, possibly nucleic acid-binding protein
SB21_RS07840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB21_RS07860	COG4839	cell division protein FtsL
SB21_RS07865	COG0768	penicillin binding
SB21_RS07870	COG0768	penicillin binding
SB21_RS07890	COG0772	Belongs to the SEDS family
SB21_RS07905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SB21_RS07910	COG0849	cell division
SB21_RS07915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SB21_RS07920	COG1404	Belongs to the peptidase S8 family
SB21_RS07920	COG4412	M6 family metalloprotease domain protein
SB21_RS07930	COG1191	sigma factor activity
SB21_RS07935	COG1191	sigma factor activity
SB21_RS07940	COG1119	ATPase activity
SB21_RS07945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB21_RS07950	COG1873	PFAM PRC-barrel domain
SB21_RS07955	COG1496	oxidoreductase activity
SB21_RS07960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SB21_RS07970	COG0762	integral membrane protein
SB21_RS07975	COG2302	S4 RNA-binding domain
SB21_RS07980	COG3599	regulation of cell shape
SB21_RS07990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SB21_RS07995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB21_RS08005	COG0564	pseudouridine synthase activity
SB21_RS08015	COG2233	PERMEase
SB21_RS08025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SB21_RS08030	COG0505	Belongs to the CarA family
SB21_RS08035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB21_RS08050	COG0284	orotidine-5'-phosphate decarboxylase activity
SB21_RS08055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SB21_RS08065	COG0306	phosphate transporter
SB21_RS08085	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SB21_RS08090	COG1648	precorrin-2 dehydrogenase activity
SB21_RS08115	COG1561	YicC-like family, N-terminal region
SB21_RS08125	COG0194	GDP metabolic process
SB21_RS08135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB21_RS08140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB21_RS08145	COG0242	peptide deformylase activity
SB21_RS08155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB21_RS08155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SB21_RS08165	COG0631	protein serine/threonine phosphatase activity
SB21_RS08170	COG0515	serine threonine protein kinase
SB21_RS08170	COG2815	serine threonine protein kinase
SB21_RS08180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB21_RS08185	COG1564	THIamine pyrophosphokinase
SB21_RS08200	COG1302	Protein conserved in bacteria
SB21_RS08205	COG1461	Dihydroxyacetone kinase
SB21_RS08210	COG1760	l-serine dehydratase
SB21_RS08215	COG1760	l-serine dehydratase
SB21_RS08220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SB21_RS08235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB21_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS08255	COG1196	nuclear chromosome segregation
SB21_RS08260	COG0552	protein localization to endoplasmic reticulum
SB21_RS08275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SB21_RS08285	COG1837	Belongs to the UPF0109 family
SB21_RS08310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB21_RS08325	COG2257	FlhB HrpN YscU SpaS Family
SB21_RS08335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SB21_RS08340	COG0758	DNA mediated transformation
SB21_RS08345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB21_RS08355	COG4974	Belongs to the 'phage' integrase family
SB21_RS08375	COG1815	bacterial-type flagellum-dependent cell motility
SB21_RS08380	COG1558	bacterial-type flagellum-dependent cell motility
SB21_RS08385	COG1677	Flagellar hook-basal body complex protein FliE
SB21_RS08390	COG1766	The M ring may be actively involved in energy transduction
SB21_RS08395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB21_RS08400	COG1317	bacterial-type flagellum organization
SB21_RS08405	COG1157	protein secretion by the type III secretion system
SB21_RS08410	COG2882	bacterial-type flagellum organization
SB21_RS08415	COG3334	PFAM MgtE intracellular
SB21_RS08420	COG3144	bacterial-type flagellum assembly
SB21_RS08425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SB21_RS08430	COG4786	Flagellar basal body rod
SB21_RS08435	COG1582	Flagellar protein (FlbD)
SB21_RS08440	COG1580	Controls the rotational direction of flagella during chemotaxis
SB21_RS08445	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB21_RS08450	COG1776	CheC inhibitor of MCP methylation
SB21_RS08450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB21_RS08455	COG2201	protein-glutamate methylesterase activity
SB21_RS08460	COG3190	flagellar
SB21_RS08465	COG1338	Plays a role in the flagellum-specific transport system
SB21_RS08470	COG1987	bacterial-type flagellum assembly
SB21_RS08475	COG1684	flagellar biosynthetic protein fliR
SB21_RS08480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB21_RS08485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB21_RS08490	COG1419	protein localization to endoplasmic reticulum
SB21_RS08495	COG0455	bacterial-type flagellum organization
SB21_RS08500	COG2201	protein-glutamate methylesterase activity
SB21_RS08505	COG2198	Histidine kinase
SB21_RS08505	COG0643	Histidine kinase
SB21_RS08510	COG0835	chemotaxis
SB21_RS08515	COG1776	CheC inhibitor of MCP methylation
SB21_RS08525	COG1191	sigma factor activity
SB21_RS08555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SB21_RS08560	COG4589	Belongs to the CDS family
SB21_RS08570	COG0750	zinc metalloprotease
SB21_RS08590	COG0195	Participates in both transcription termination and antitermination
SB21_RS08595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SB21_RS08600	COG1358	cellular component organization or biogenesis
SB21_RS08610	COG1550	Protein conserved in bacteria
SB21_RS08625	COG0196	riboflavin kinase activity
SB21_RS08640	COG0726	polysaccharide deacetylase
SB21_RS08645	COG0612	Peptidase, M16
SB21_RS08650	COG1873	PFAM PRC-barrel domain
SB21_RS08655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB21_RS08665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SB21_RS08670	COG0527	aspartate kinase activity
SB21_RS08680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB21_RS08685	COG0740	serine-type endopeptidase activity
SB21_RS08695	COG1674	ftsk spoiiie
SB21_RS08695	COG4980	gas vesicle protein
SB21_RS08700	COG2188	Transcriptional regulator
SB21_RS08705	COG2814	Major facilitator Superfamily
SB21_RS08710	COG1846	Transcriptional regulator
SB21_RS08715	COG2409	Drug exporters of the RND superfamily
SB21_RS08715	COG1033	growth of symbiont in host cell
SB21_RS08720	COG0612	Peptidase, M16
SB21_RS08725	COG0612	Peptidase, M16
SB21_RS08730	COG0300	oxidoreductase activity
SB21_RS08745	COG1426	Protein conserved in bacteria
SB21_RS08750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SB21_RS08765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SB21_RS08775	COG1692	metallophosphoesterase
SB21_RS08780	COG2359	stage V sporulation protein S
SB21_RS08800	COG4550	Control of competence regulator ComK, YlbF/YmcA
SB21_RS08820	COG0582	viral genome integration into host DNA
SB21_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS08870	COG3425	synthase
SB21_RS08875	COG1024	Enoyl-CoA hydratase
SB21_RS08880	COG1024	Enoyl-CoA hydratase
SB21_RS08890	COG4221	oxidoreductase activity
SB21_RS08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS08890	COG3321	synthase
SB21_RS08890	COG0300	oxidoreductase activity
SB21_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS08895	COG3321	synthase
SB21_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS08895	COG3321	synthase
SB21_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS08900	COG4221	oxidoreductase activity
SB21_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS08900	COG3321	synthase
SB21_RS08900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS08905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS08905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SB21_RS08905	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SB21_RS08905	COG3321	synthase
SB21_RS08910	COG2124	cytochrome p450
SB21_RS08915	COG3209	COG3209 Rhs family protein
SB21_RS08930	COG1404	Belongs to the peptidase S8 family
SB21_RS08940	COG4195	phage-related replication protein
SB21_RS08945	COG1764	response to oxidative stress
SB21_RS08955	COG2076	Multidrug Resistance protein
SB21_RS08995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB21_RS09000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB21_RS09005	COG4112	unkown
SB21_RS09010	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS09020	COG0464	growth
SB21_RS09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SB21_RS09030	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SB21_RS09035	COG0789	Transcriptional regulator
SB21_RS09040	COG0174	glutamine synthetase
SB21_RS09075	COG3507	Belongs to the glycosyl hydrolase 43 family
SB21_RS09090	COG1070	Carbohydrate kinase
SB21_RS09095	COG0574	Belongs to the PEP-utilizing enzyme family
SB21_RS09095	COG3848	Pyruvate phosphate dikinase
SB21_RS09120	COG1064	alcohol dehydrogenase
SB21_RS09180	COG3397	chitin binding
SB21_RS09190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS09200	COG5434	Belongs to the glycosyl hydrolase 28 family
SB21_RS09205	COG0756	dUTP diphosphatase activity
SB21_RS09215	COG4195	phage-related replication protein
SB21_RS09245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SB21_RS09255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SB21_RS09275	COG0785	Cytochrome C biogenesis protein
SB21_RS09280	COG2201	protein-glutamate methylesterase activity
SB21_RS09285	COG4846	Membrane protein involved in cytochrome C biogenesis
SB21_RS09295	COG0071	Belongs to the small heat shock protein (HSP20) family
SB21_RS09310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SB21_RS09315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS09335	COG0824	Thioesterase
SB21_RS09345	COG4841	protein insertion into membrane
SB21_RS09355	COG1832	CoA-binding protein
SB21_RS09360	COG0187	DNA topoisomerase II activity
SB21_RS09375	COG1115	amino acid carrier protein
SB21_RS09385	COG1063	alcohol dehydrogenase
SB21_RS09390	COG0800	Aldolase
SB21_RS09395	COG1312	Catalyzes the dehydration of D-mannonate
SB21_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS09405	COG1609	Transcriptional regulator
SB21_RS09435	COG1136	(ABC) transporter
SB21_RS09435	COG0577	efflux transmembrane transporter activity
SB21_RS09465	COG2205	protein histidine kinase activity
SB21_RS09470	COG0745	RESPONSE REGULATOR receiver
SB21_RS09480	COG3507	Belongs to the glycosyl hydrolase 43 family
SB21_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS09510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SB21_RS09515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SB21_RS09520	COG2610	gluconate transmembrane transporter activity
SB21_RS09525	COG2124	cytochrome p450
SB21_RS09545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB21_RS09555	COG2246	polysaccharide biosynthetic process
SB21_RS09570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB21_RS09575	COG1024	Enoyl-CoA hydratase
SB21_RS09580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB21_RS09585	COG0511	ligase activity, forming carbon-carbon bonds
SB21_RS09590	COG0439	Biotin carboxylase
SB21_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS09600	COG1960	acyl-CoA dehydrogenase activity
SB21_RS09605	COG1649	PFAM Uncharacterised BCR, COG1649
SB21_RS09615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS09615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SB21_RS09620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS09635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS09645	COG2027	D-alanyl-D-alanine carboxypeptidase
SB21_RS09650	COG2017	converts alpha-aldose to the beta-anomer
SB21_RS09655	COG0534	Mate efflux family protein
SB21_RS09670	COG0582	viral genome integration into host DNA
SB21_RS09675	COG0166	Belongs to the GPI family
SB21_RS09680	COG0405	Gamma-glutamyltransferase
SB21_RS09685	COG2814	Major facilitator Superfamily
SB21_RS09690	COG0640	Transcriptional regulator
SB21_RS09695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SB21_RS09705	COG0604	alcohol dehydrogenase
SB21_RS09715	COG0493	'glutamate synthase
SB21_RS09720	COG0069	glutamate synthase activity
SB21_RS09720	COG0067	glutamate synthase
SB21_RS09720	COG0070	glutamate synthase
SB21_RS09725	COG0583	DNA-binding transcription factor activity
SB21_RS09730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB21_RS09745	COG0300	oxidoreductase activity
SB21_RS09750	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SB21_RS09760	COG2814	Major facilitator Superfamily
SB21_RS09765	COG1070	Carbohydrate kinase
SB21_RS09770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB21_RS09775	COG0243	molybdopterin cofactor binding
SB21_RS09805	COG5444	nuclease activity
SB21_RS09810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB21_RS09815	COG0662	Cupin 2, conserved barrel domain protein
SB21_RS09815	COG2207	Transcriptional regulator
SB21_RS09820	COG1309	transcriptional regulator
SB21_RS09825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB21_RS09835	COG0640	Transcriptional regulator
SB21_RS09840	COG0741	lytic transglycosylase activity
SB21_RS09845	COG2322	membrane
SB21_RS09860	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB21_RS09870	COG1388	LysM domain
SB21_RS09870	COG3584	3D domain protein
SB21_RS09885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SB21_RS09890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB21_RS09905	COG0071	Belongs to the small heat shock protein (HSP20) family
SB21_RS09940	COG1657	PFAM Prenyltransferase squalene oxidase
SB21_RS09945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB21_RS09955	COG0385	Bile acid
SB21_RS09960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB21_RS09965	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB21_RS09975	COG4548	von Willebrand factor, type A
SB21_RS09980	COG0714	Associated with various cellular activities
SB21_RS09985	COG2032	superoxide dismutase activity
SB21_RS09990	COG1388	LysM domain
SB21_RS09990	COG0791	NLP P60 protein
SB21_RS09995	COG1819	glycosyl
SB21_RS10000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB21_RS10005	COG0534	Mate efflux family protein
SB21_RS10010	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS10015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB21_RS10020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB21_RS10030	COG2962	Rard protein
SB21_RS10045	COG1942	4-Oxalocrotonate Tautomerase
SB21_RS10055	COG1733	regulation of RNA biosynthetic process
SB21_RS10060	COG0778	Nitroreductase
SB21_RS10065	COG0400	carboxylic ester hydrolase activity
SB21_RS10070	COG0346	lactoylglutathione lyase activity
SB21_RS10080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB21_RS10095	COG2188	Transcriptional regulator
SB21_RS10100	COG0793	Belongs to the peptidase S41A family
SB21_RS10100	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS10115	COG1876	peptidase activity
SB21_RS10135	COG0671	phosphoesterase, PA-phosphatase related
SB21_RS10165	COG1509	lysine 2,3-aminomutase activity
SB21_RS10170	COG0456	acetyltransferase
SB21_RS10175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB21_RS10180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SB21_RS10185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SB21_RS10190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB21_RS10195	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SB21_RS10205	COG0456	acetyltransferase
SB21_RS10210	COG0463	Glycosyl transferase, family 2
SB21_RS10225	COG4641	Protein conserved in bacteria
SB21_RS10235	COG1086	Polysaccharide biosynthesis protein
SB21_RS10250	COG1846	Transcriptional regulator
SB21_RS10255	COG4698	Protein conserved in bacteria
SB21_RS10260	COG2755	lipolytic protein G-D-S-L family
SB21_RS10265	COG1999	signal sequence binding
SB21_RS10275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SB21_RS10280	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB21_RS10285	COG1272	protein, Hemolysin III
SB21_RS10290	COG0204	Acyl-transferase
SB21_RS10295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB21_RS10310	COG2521	methyltransferase
SB21_RS10310	COG2136	Putative SAM-dependent methyltransferase
SB21_RS10325	COG1413	lyase activity
SB21_RS10330	COG1418	mRNA catabolic process
SB21_RS10335	COG0386	Belongs to the glutathione peroxidase family
SB21_RS10345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB21_RS10355	COG1278	Cold shock
SB21_RS10375	COG0328	RNA-DNA hybrid ribonuclease activity
SB21_RS10380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SB21_RS10385	COG0328	RNA-DNA hybrid ribonuclease activity
SB21_RS10395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB21_RS10410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB21_RS10420	COG1755	Isoprenylcysteine carboxyl methyltransferase
SB21_RS10445	COG2323	membrane
SB21_RS10450	COG1335	isochorismatase
SB21_RS10460	COG2233	PERMEase
SB21_RS10470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SB21_RS10475	COG1199	ATP-dependent helicase activity
SB21_RS10490	COG0116	Belongs to the methyltransferase superfamily
SB21_RS10520	COG3359	exonuclease
SB21_RS10525	COG1205	dead DEAH box helicase
SB21_RS10525	COG1111	helicase
SB21_RS10530	COG2190	(PTS) system
SB21_RS10535	COG0071	Belongs to the small heat shock protein (HSP20) family
SB21_RS10585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SB21_RS10590	COG3935	DnaD domain protein
SB21_RS10600	COG0436	Aminotransferase
SB21_RS10605	COG5353	protein conserved in bacteria
SB21_RS10615	COG1199	ATP-dependent helicase activity
SB21_RS10615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SB21_RS10645	COG0438	transferase activity, transferring glycosyl groups
SB21_RS10650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB21_RS10665	COG1694	Mazg nucleotide pyrophosphohydrolase
SB21_RS10670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS10675	COG2140	Oxalate decarboxylase
SB21_RS10685	COG4347	Protein of unknown function (DUF1405)
SB21_RS10690	COG2010	Cytochrome c
SB21_RS10690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB21_RS10695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB21_RS10700	COG0723	plastoquinol--plastocyanin reductase activity
SB21_RS10715	COG0457	Tetratricopeptide repeat
SB21_RS10725	COG0287	Prephenate dehydrogenase
SB21_RS10760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SB21_RS10765	COG4401	Chorismate mutase type I
SB21_RS10780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB21_RS10785	COG0105	UTP biosynthetic process
SB21_RS10790	COG0142	geranyltranstransferase activity
SB21_RS10800	COG0142	geranyltranstransferase activity
SB21_RS10815	COG0776	regulation of translation
SB21_RS10820	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB21_RS10860	COG0539	negative regulation of cytoplasmic translation
SB21_RS10875	COG2959	enzyme of heme biosynthesis
SB21_RS10880	COG3773	Cell wall hydrolase
SB21_RS10880	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS10885	COG2339	peptidase activity
SB21_RS10890	COG0492	ferredoxin-NADP+ reductase activity
SB21_RS10895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB21_RS10900	COG4862	establishment of competence for transformation
SB21_RS10905	COG1408	metallophosphoesterase
SB21_RS10915	COG1388	LysM domain
SB21_RS10920	COG1266	CAAX protease self-immunity
SB21_RS10925	COG0514	ATP-dependent DNA helicase (RecQ)
SB21_RS10930	COG4955	Helix-turn-helix domain
SB21_RS10935	COG1141	Ferredoxin
SB21_RS10940	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SB21_RS10945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB21_RS10955	COG1595	DNA-templated transcription, initiation
SB21_RS10960	COG5002	protein histidine kinase activity
SB21_RS10965	COG0745	RESPONSE REGULATOR receiver
SB21_RS10970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB21_RS10975	COG1333	cytochrome c biogenesis protein
SB21_RS10980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS10985	COG1187	pseudouridine synthase activity
SB21_RS10990	COG0700	Nucleoside recognition
SB21_RS11000	COG1686	Belongs to the peptidase S11 family
SB21_RS11025	COG1547	Domain of unknown function (DUF309)
SB21_RS11035	COG0456	acetyltransferase
SB21_RS11050	COG0307	riboflavin synthase, alpha
SB21_RS11055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB21_RS11055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB21_RS11065	COG0681	Belongs to the peptidase S26 family
SB21_RS11075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SB21_RS11080	COG4086	secreted protein
SB21_RS11085	COG0019	diaminopimelate decarboxylase activity
SB21_RS11090	COG0697	spore germination
SB21_RS11105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB21_RS11125	COG1191	sigma factor activity
SB21_RS11135	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS11140	COG1686	Belongs to the peptidase S11 family
SB21_RS11145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SB21_RS11150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SB21_RS11155	COG4974	Belongs to the 'phage' integrase family
SB21_RS11165	COG0735	belongs to the Fur family
SB21_RS11170	COG1300	Membrane
SB21_RS11185	COG0281	malic enzyme
SB21_RS11190	COG1757	Na H antiporter
SB21_RS11195	COG1027	Aspartate ammonia-lyase
SB21_RS11200	COG0252	asparaginase activity
SB21_RS11205	COG1396	sequence-specific DNA binding
SB21_RS11210	COG1379	DNA repair
SB21_RS11215	COG0494	nUDIX hydrolase
SB21_RS11225	COG0667	Aldo Keto reductase
SB21_RS11235	COG1073	alpha beta
SB21_RS11245	COG4918	Iron-sulphur cluster biosynthesis
SB21_RS11250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SB21_RS11250	COG0456	acetyltransferase
SB21_RS11255	COG2329	Antibiotic biosynthesis monooxygenase
SB21_RS11260	COG0456	acetyltransferase
SB21_RS11265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB21_RS11280	COG0628	permease
SB21_RS11290	COG0346	lactoylglutathione lyase activity
SB21_RS11300	COG3048	D-serine ammonia-lyase activity
SB21_RS11305	COG0300	oxidoreductase activity
SB21_RS11310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB21_RS11315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB21_RS11320	COG1024	Enoyl-CoA hydratase
SB21_RS11325	COG3425	synthase
SB21_RS11330	COG2124	cytochrome p450
SB21_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS11335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS11335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS11335	COG3321	synthase
SB21_RS11360	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS11360	COG3321	synthase
SB21_RS11360	COG0300	oxidoreductase activity
SB21_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS11365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS11365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS11365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB21_RS11365	COG3321	synthase
SB21_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS11375	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS11390	COG2070	2-Nitropropane dioxygenase
SB21_RS11390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB21_RS11400	COG0250	Participates in transcription elongation, termination and antitermination
SB21_RS11425	COG0596	Alpha beta hydrolase
SB21_RS11440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SB21_RS11445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SB21_RS11460	COG0706	membrane insertase activity
SB21_RS11465	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB21_RS11470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB21_RS11475	COG0346	lactoylglutathione lyase activity
SB21_RS11480	COG1376	ErfK ybiS ycfS ynhG family protein
SB21_RS11485	COG4129	membrane
SB21_RS11490	COG1126	abc transporter atp-binding protein
SB21_RS11495	COG0765	amino acid transport
SB21_RS11500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS11510	COG1597	lipid kinase activity
SB21_RS11515	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB21_RS11520	COG0022	dehydrogenase e1 component
SB21_RS11525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB21_RS11530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB21_RS11535	COG3426	butyrate kinase activity
SB21_RS11540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB21_RS11545	COG0280	phosphate acetyltransferase
SB21_RS11550	COG3290	protein histidine kinase activity
SB21_RS11550	COG3829	transcription factor binding
SB21_RS11560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SB21_RS11565	COG2079	MmgE PrpD family protein
SB21_RS11570	COG0372	Belongs to the citrate synthase family
SB21_RS11575	COG1960	acyl-CoA dehydrogenase activity
SB21_RS11580	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB21_RS11585	COG0183	Belongs to the thiolase family
SB21_RS11590	COG0584	glycerophosphoryl diester phosphodiesterase
SB21_RS11595	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS11615	COG1902	pentaerythritol trinitrate reductase activity
SB21_RS11630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SB21_RS11640	COG0745	RESPONSE REGULATOR receiver
SB21_RS11645	COG0750	zinc metalloprotease
SB21_RS11650	COG0497	DNA recombination
SB21_RS11670	COG0142	geranyltranstransferase activity
SB21_RS11695	COG1302	Protein conserved in bacteria
SB21_RS11700	COG0439	Biotin carboxylase
SB21_RS11705	COG0511	ligase activity, forming carbon-carbon bonds
SB21_RS11745	COG3854	ATPases associated with a variety of cellular activities
SB21_RS11760	COG0006	proline dipeptidase activity
SB21_RS11770	COG3872	metal-dependent enzyme
SB21_RS11780	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB21_RS11795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB21_RS11815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB21_RS11830	COG1396	sequence-specific DNA binding
SB21_RS11840	COG0681	Belongs to the peptidase S26 family
SB21_RS11865	COG4940	Competence protein ComGF
SB21_RS11875	COG4970	Tfp pilus assembly protein FimT
SB21_RS11880	COG4537	Required for transformation and DNA binding
SB21_RS11885	COG1459	type II secretion system
SB21_RS11890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB21_RS11895	COG0598	Magnesium transport protein CorA
SB21_RS11900	COG1253	flavin adenine dinucleotide binding
SB21_RS11905	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS11915	COG1393	Belongs to the ArsC family
SB21_RS11935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SB21_RS11950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB21_RS11955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB21_RS11960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB21_RS11965	COG0581	inorganic phosphate transmembrane transporter activity
SB21_RS11970	COG0573	inorganic phosphate transmembrane transporter activity
SB21_RS11975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SB21_RS11980	COG0768	penicillin binding
SB21_RS11985	COG0477	Major facilitator Superfamily
SB21_RS11990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB21_RS11995	COG2839	Protein conserved in bacteria
SB21_RS12000	COG5521	maltodextrose utilization protein MalA
SB21_RS12005	COG1388	LysM domain
SB21_RS12015	COG4709	membrane
SB21_RS12020	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
SB21_RS12025	COG0735	belongs to the Fur family
SB21_RS12030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS12060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SB21_RS12065	COG2384	SAM-dependent methyltransferase
SB21_RS12070	COG2010	Cytochrome c
SB21_RS12075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SB21_RS12080	COG0358	DNA primase activity
SB21_RS12095	COG0517	IMP dehydrogenase activity
SB21_RS12100	COG0751	glycine-tRNA ligase activity
SB21_RS12120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SB21_RS12125	COG0295	cytidine deaminase activity
SB21_RS12130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SB21_RS12140	COG1480	7TM receptor with intracellular HD hydrolase
SB21_RS12145	COG1702	phosphate starvation-inducible protein PhoH
SB21_RS12165	COG4864	UPF0365 protein
SB21_RS12170	COG1030	water channel activity
SB21_RS12175	COG1610	YqeY-like protein
SB21_RS12185	COG1283	sodium-dependent phosphate transmembrane transporter activity
SB21_RS12190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB21_RS12195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SB21_RS12225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB21_RS12240	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS12255	COG1466	dna polymerase III delta subunit
SB21_RS12270	COG2333	competence protein COMEC
SB21_RS12270	COG0658	competence protein
SB21_RS12275	COG2131	deaminase
SB21_RS12280	COG1596	polysaccharide export
SB21_RS12280	COG1555	photosystem II stabilization
SB21_RS12285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB21_RS12290	COG2226	methyltransferase
SB21_RS12295	COG0799	negative regulation of ribosome biogenesis
SB21_RS12300	COG1713	HD superfamily hydrolase involved in NAD metabolism
SB21_RS12310	COG1534	Rna-binding protein
SB21_RS12315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SB21_RS12320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB21_RS12325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SB21_RS12335	COG2755	lipolytic protein G-D-S-L family
SB21_RS12345	COG0398	Pfam SNARE associated Golgi protein
SB21_RS12390	COG5444	nuclease activity
SB21_RS12395	COG4282	regulation of fungal-type cell wall biogenesis
SB21_RS12410	COG3708	Transcriptional regulator
SB21_RS12410	COG2207	Transcriptional regulator
SB21_RS12420	COG0563	adenylate kinase activity
SB21_RS12425	COG2814	Major facilitator Superfamily
SB21_RS12435	COG0456	acetyltransferase
SB21_RS12440	COG2318	DinB family
SB21_RS12450	COG0561	phosphatase activity
SB21_RS12455	COG0561	phosphatase activity
SB21_RS12465	COG1482	cell wall glycoprotein biosynthetic process
SB21_RS12470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS12470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB21_RS12470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB21_RS12475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS12475	COG3711	transcriptional antiterminator
SB21_RS12485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB21_RS12490	COG0583	DNA-binding transcription factor activity
SB21_RS12495	COG2814	Major facilitator Superfamily
SB21_RS12500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB21_RS12500	COG2124	cytochrome p450
SB21_RS12505	COG1309	transcriptional regulator
SB21_RS12510	COG2226	methyltransferase
SB21_RS12525	COG2116	formate transmembrane transporter activity
SB21_RS12530	COG5609	conserved protein (DUF2294)
SB21_RS12535	COG3383	formate dehydrogenase (NAD+) activity
SB21_RS12540	COG2427	Protein of unknown function (DUF1641)
SB21_RS12550	COG0626	cystathionine gamma-synthase activity
SB21_RS12555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB21_RS12595	COG0826	peptidase U32
SB21_RS12600	COG0826	peptidase U32
SB21_RS12605	COG4122	O-methyltransferase activity
SB21_RS12610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB21_RS12635	COG0628	permease
SB21_RS12640	COG1126	abc transporter atp-binding protein
SB21_RS12645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS12650	COG0765	amino acid transport
SB21_RS12655	COG0765	amino acid transport
SB21_RS12670	COG3881	PFAM PRC-barrel domain
SB21_RS12675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SB21_RS12680	COG0457	Tetratricopeptide repeat
SB21_RS12690	COG1104	cysteine desulfurase activity
SB21_RS12695	COG1959	2 iron, 2 sulfur cluster binding
SB21_RS12700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB21_RS12705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SB21_RS12725	COG4991	sh3 domain protein
SB21_RS12725	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS12725	COG3103	Sh3 type 3 domain protein
SB21_RS12735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB21_RS12745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SB21_RS12745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SB21_RS12750	COG5416	Lipopolysaccharide assembly protein A domain
SB21_RS12755	COG0490	domain, Protein
SB21_RS12760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB21_RS12760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB21_RS12775	COG2323	membrane
SB21_RS12785	COG1862	Preprotein translocase
SB21_RS12830	COG1388	LysM domain
SB21_RS12840	COG0157	Belongs to the NadC ModD family
SB21_RS12845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SB21_RS12850	COG1104	cysteine desulfurase activity
SB21_RS12855	COG1827	regulation of RNA biosynthetic process
SB21_RS12860	COG0077	Prephenate dehydratase
SB21_RS12875	COG3290	protein histidine kinase activity
SB21_RS12880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SB21_RS12885	COG2868	ribosomal protein
SB21_RS12895	COG1994	Peptidase M50
SB21_RS12900	COG0739	heme binding
SB21_RS12905	COG2894	cell division
SB21_RS12915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SB21_RS12925	COG1077	Cell shape determining protein MreB Mrl
SB21_RS12950	COG0285	dihydrofolate synthase activity
SB21_RS12955	COG0525	valine-tRNA ligase activity
SB21_RS12965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB21_RS12970	COG1388	LysM domain
SB21_RS12980	COG0113	porphobilinogen synthase activity
SB21_RS12985	COG1587	Uroporphyrinogen-III synthase
SB21_RS12995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB21_RS13015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SB21_RS13020	COG1067	ATP-dependent peptidase activity
SB21_RS13020	COG0470	DNA polymerase III
SB21_RS13035	COG1477	protein flavinylation
SB21_RS13035	COG0457	Tetratricopeptide repeat
SB21_RS13065	COG0440	acetolactate synthase activity
SB21_RS13095	COG0622	Phosphoesterase
SB21_RS13100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SB21_RS13110	COG5401	PFAM Sporulation and spore germination
SB21_RS13120	COG1846	Transcriptional regulator
SB21_RS13125	COG2197	response regulator
SB21_RS13130	COG0824	Thioesterase
SB21_RS13135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SB21_RS13140	COG1053	succinate dehydrogenase
SB21_RS13145	COG2009	succinate dehydrogenase
SB21_RS13150	COG1719	4-vinyl reductase, 4VR
SB21_RS13155	COG0527	aspartate kinase activity
SB21_RS13170	COG3118	belongs to the thioredoxin family
SB21_RS13175	COG3534	alpha-L-arabinofuranosidase
SB21_RS13180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SB21_RS13185	COG2086	electron transfer activity
SB21_RS13190	COG1024	Enoyl-CoA hydratase
SB21_RS13195	COG1309	transcriptional regulator
SB21_RS13200	COG0318	PFAM AMP-dependent synthetase and ligase
SB21_RS13210	COG3766	membrane
SB21_RS13220	COG1796	DNA polymerase
SB21_RS13220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB21_RS13225	COG1286	toxin biosynthetic process
SB21_RS13240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB21_RS13240	COG0072	phenylalanine-tRNA ligase activity
SB21_RS13245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SB21_RS13250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB21_RS13260	COG3835	regulator
SB21_RS13265	COG0277	FAD linked oxidase domain protein
SB21_RS13270	COG0247	lactate metabolic process
SB21_RS13275	COG1966	Carbon starvation protein
SB21_RS13285	COG0395	ABC-type sugar transport system, permease component
SB21_RS13290	COG1175	transmembrane transport
SB21_RS13295	COG1653	transport
SB21_RS13310	COG0235	Class ii aldolase
SB21_RS13315	COG1069	ribulokinase activity
SB21_RS13320	COG2160	L-arabinose isomerase activity
SB21_RS13330	COG1363	Peptidase, m42
SB21_RS13340	COG3326	Membrane
SB21_RS13345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SB21_RS13355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SB21_RS13365	COG1380	Effector of murein hydrolase LrgA
SB21_RS13380	COG1011	Hydrolase
SB21_RS13400	COG0398	Pfam SNARE associated Golgi protein
SB21_RS13405	COG1484	DNA-dependent DNA replication
SB21_RS13410	COG3611	Membrane attachment protein
SB21_RS13425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB21_RS13430	COG1733	regulation of RNA biosynthetic process
SB21_RS13435	COG2814	Major facilitator Superfamily
SB21_RS13440	COG0656	L-ascorbic acid biosynthetic process
SB21_RS13445	COG0237	dephospho-CoA kinase activity
SB21_RS13450	COG1971	Probably functions as a manganese efflux pump
SB21_RS13455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB21_RS13460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB21_RS13460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB21_RS13465	COG5002	protein histidine kinase activity
SB21_RS13470	COG0745	RESPONSE REGULATOR receiver
SB21_RS13480	COG0538	isocitrate dehydrogenase activity
SB21_RS13485	COG0372	Belongs to the citrate synthase family
SB21_RS13505	COG0628	permease
SB21_RS13510	COG3030	protein affecting phage T7 exclusion by the F plasmid
SB21_RS13515	COG0469	pyruvate kinase activity
SB21_RS13535	COG0281	malic enzyme
SB21_RS13540	COG0587	DNA-directed DNA polymerase activity
SB21_RS13560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SB21_RS13570	COG4109	DRTGG domain
SB21_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS13595	COG0521	Mo-molybdopterin cofactor biosynthetic process
SB21_RS13610	COG0827	DNA restriction-modification system
SB21_RS13615	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SB21_RS13620	COG3874	Sporulation protein YtfJ
SB21_RS13630	COG1714	RDD family
SB21_RS13635	COG0616	signal peptide processing
SB21_RS13640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SB21_RS13645	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SB21_RS13650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB21_RS13665	COG1104	cysteine desulfurase activity
SB21_RS13670	COG1114	Component of the transport system for branched-chain amino acids
SB21_RS13680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB21_RS13685	COG1309	transcriptional regulator
SB21_RS13690	COG1956	GAF domain-containing protein
SB21_RS13695	COG2203	Gaf domain
SB21_RS13695	COG2199	diguanylate cyclase activity
SB21_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS13750	COG1017	nitric oxide dioxygenase activity
SB21_RS13750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SB21_RS13765	COG0693	protein deglycase activity
SB21_RS13780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB21_RS13785	COG1378	Sugar-specific transcriptional regulator TrmB
SB21_RS13810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB21_RS13815	COG0454	-acetyltransferase
SB21_RS13820	COG0517	IMP dehydrogenase activity
SB21_RS13825	COG0123	including yeast histone deacetylase and acetoin utilization protein
SB21_RS13830	COG1360	Flagellar Motor Protein
SB21_RS13835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB21_RS13840	COG1609	Transcriptional regulator
SB21_RS13845	COG1605	Chorismate mutase
SB21_RS13845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SB21_RS13850	COG3118	belongs to the thioredoxin family
SB21_RS13855	COG4980	gas vesicle protein
SB21_RS13860	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SB21_RS13870	COG1674	ftsk spoiiie
SB21_RS13875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB21_RS13885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS13895	COG1363	Peptidase, m42
SB21_RS13900	COG5584	Small secreted protein
SB21_RS13905	COG0281	malic enzyme
SB21_RS13910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB21_RS13925	COG0510	thiamine kinase activity
SB21_RS13930	COG1597	lipid kinase activity
SB21_RS13940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SB21_RS13945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB21_RS13950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB21_RS13955	COG2252	PERMEase
SB21_RS13960	COG4473	ABC transporter
SB21_RS13965	COG1131	(ABC) transporter
SB21_RS13970	COG1349	DNA-binding transcription factor activity
SB21_RS13975	COG1187	pseudouridine synthase activity
SB21_RS13980	COG2244	polysaccharide biosynthetic process
SB21_RS13985	COG2081	HI0933 family
SB21_RS13990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SB21_RS14000	COG1609	Transcriptional regulator
SB21_RS14005	COG1653	transport
SB21_RS14010	COG1175	transmembrane transport
SB21_RS14015	COG0395	ABC-type sugar transport system, permease component
SB21_RS14020	COG1486	melibiose metabolic process
SB21_RS14030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB21_RS14045	COG2202	Pas domain
SB21_RS14045	COG1366	Belongs to the anti-sigma-factor antagonist family
SB21_RS14055	COG2814	Major facilitator Superfamily
SB21_RS14060	COG5522	Integral membrane protein (intg_mem_TP0381)
SB21_RS14065	COG0577	efflux transmembrane transporter activity
SB21_RS14070	COG1136	(ABC) transporter
SB21_RS14075	COG2205	protein histidine kinase activity
SB21_RS14080	COG0745	RESPONSE REGULATOR receiver
SB21_RS14085	COG0577	efflux transmembrane transporter activity
SB21_RS14090	COG1136	(ABC) transporter
SB21_RS14110	COG1131	(ABC) transporter
SB21_RS14115	COG1725	Transcriptional regulator
SB21_RS14130	COG0640	Transcriptional regulator
SB21_RS14170	COG0477	Major facilitator Superfamily
SB21_RS14175	COG1242	4 iron, 4 sulfur cluster binding
SB21_RS14180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SB21_RS14190	COG0584	glycerophosphoryl diester phosphodiesterase
SB21_RS14200	COG2267	carboxylic ester hydrolase activity
SB21_RS14210	COG1113	amino acid transport
SB21_RS14215	COG0367	asparagine synthase
SB21_RS14235	COG1506	peptidase
SB21_RS14240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB21_RS14245	COG1116	anion transmembrane transporter activity
SB21_RS14250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB21_RS14255	COG0494	nUDIX hydrolase
SB21_RS14260	COG4824	toxin secretion phage lysis holin
SB21_RS14265	COG0783	Belongs to the Dps family
SB21_RS14290	COG0288	reversible hydration of carbon dioxide
SB21_RS14300	COG1271	oxidase subunit
SB21_RS14305	COG1294	oxidase, subunit
SB21_RS14330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SB21_RS14335	COG0596	Alpha beta hydrolase
SB21_RS14345	COG1169	isochorismate synthase
SB21_RS14350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB21_RS14355	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SB21_RS14480	COG3859	Proton-coupled thiamine transporter YuaJ
SB21_RS14485	COG2268	Band 7 protein
SB21_RS14490	COG1585	Membrane protein implicated in regulation of membrane protease activity
SB21_RS14495	COG2318	DinB family
SB21_RS14505	COG1454	alcohol dehydrogenase
SB21_RS14510	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS14515	COG1510	regulation of RNA biosynthetic process
SB21_RS14525	COG0569	domain protein
SB21_RS14530	COG1705	Flagellar rod assembly protein muramidase FlgJ
SB21_RS14535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SB21_RS14535	COG1017	nitric oxide dioxygenase activity
SB21_RS14560	COG0628	permease
SB21_RS14565	COG0673	inositol 2-dehydrogenase activity
SB21_RS14570	COG0693	protein deglycase activity
SB21_RS14575	COG0840	transmembrane signaling receptor activity
SB21_RS14580	COG0840	transmembrane signaling receptor activity
SB21_RS14585	COG0840	transmembrane signaling receptor activity
SB21_RS14590	COG0840	transmembrane signaling receptor activity
SB21_RS14605	COG2070	2-Nitropropane dioxygenase
SB21_RS14610	COG0432	Pfam Uncharacterised protein family UPF0047
SB21_RS14615	COG0366	Alpha amylase catalytic
SB21_RS14620	COG1253	flavin adenine dinucleotide binding
SB21_RS14625	COG2738	Putative neutral zinc metallopeptidase
SB21_RS14640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SB21_RS14670	COG1335	isochorismatase
SB21_RS14675	COG1979	alcohol dehydrogenase
SB21_RS14680	COG1979	alcohol dehydrogenase
SB21_RS14685	COG2155	Conserved Protein
SB21_RS14690	COG1098	S1 RNA binding domain
SB21_RS14695	COG0436	Aminotransferase
SB21_RS14700	COG1522	sequence-specific DNA binding
SB21_RS14705	COG2267	carboxylic ester hydrolase activity
SB21_RS14715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SB21_RS14720	COG2205	protein histidine kinase activity
SB21_RS14730	COG5018	Exonuclease
SB21_RS14735	COG2814	Major facilitator Superfamily
SB21_RS14740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB21_RS14745	COG3011	Protein conserved in bacteria
SB21_RS14755	COG3290	protein histidine kinase activity
SB21_RS14760	COG4565	transcriptional regulatory protein
SB21_RS14765	COG1744	ABC transporter substrate-binding protein PnrA-like
SB21_RS14775	COG4603	Belongs to the binding-protein-dependent transport system permease family
SB21_RS14780	COG1079	Belongs to the binding-protein-dependent transport system permease family
SB21_RS14790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SB21_RS14790	COG2111	Na H antiporter
SB21_RS14795	COG2111	Na H antiporter
SB21_RS14800	COG1006	Multisubunit Na H antiporter MnhC subunit
SB21_RS14805	COG0651	ATP synthesis coupled electron transport
SB21_RS14810	COG1863	multisubunit Na H antiporter MnhE subunit
SB21_RS14815	COG2212	antiporter activity
SB21_RS14820	COG1320	monovalent cation:proton antiporter activity
SB21_RS14825	COG2050	protein possibly involved in aromatic compounds catabolism
SB21_RS14830	COG2197	response regulator
SB21_RS14835	COG4585	Histidine kinase
SB21_RS14845	COG0142	geranyltranstransferase activity
SB21_RS14865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SB21_RS14870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SB21_RS14875	COG1335	isochorismatase
SB21_RS14880	COG5506	Protein of unknown function (DUF1694)
SB21_RS14895	COG0628	permease
SB21_RS14905	COG1418	mRNA catabolic process
SB21_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS14920	COG1511	domain protein
SB21_RS14925	COG0433	COG0433 Predicted ATPase
SB21_RS14925	COG1674	ftsk spoiiie
SB21_RS14935	COG5417	Belongs to the EsaB family
SB21_RS14940	COG4842	Belongs to the WXG100 family
SB21_RS14945	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SB21_RS14945	COG2508	Transcriptional regulator
SB21_RS14950	COG0686	Belongs to the AlaDH PNT family
SB21_RS14955	COG5634	Uncharacterized conserved protein (DUF2278)
SB21_RS14960	COG3251	PFAM MbtH domain protein
SB21_RS14965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SB21_RS14970	COG3433	isochorismatase activity
SB21_RS14970	COG1535	isochorismatase
SB21_RS14975	COG1021	2,3-dihydroxybenzoate-AMP ligase
SB21_RS14980	COG1169	isochorismate synthase
SB21_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS14990	COG2819	hydrolase of the alpha beta superfamily
SB21_RS14995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB21_RS15000	COG1268	BioY protein
SB21_RS15005	COG2056	Na+-H+ antiporter family
SB21_RS15015	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SB21_RS15020	COG3584	3D domain protein
SB21_RS15035	COG1252	NADH dehydrogenase
SB21_RS15065	COG1131	(ABC) transporter
SB21_RS15085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB21_RS15090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SB21_RS15205	COG0582	viral genome integration into host DNA
SB21_RS15215	COG4974	Belongs to the 'phage' integrase family
SB21_RS15220	COG0316	Belongs to the HesB IscA family
SB21_RS15230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB21_RS15240	COG1252	NADH dehydrogenase
SB21_RS15245	COG4837	Protein of unknown function (DUF1462)
SB21_RS15250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SB21_RS15255	COG4946	Tricorn protease homolog
SB21_RS15255	COG1506	peptidase
SB21_RS15255	COG0823	Involved in the tonB-independent uptake of proteins
SB21_RS15265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SB21_RS15270	COG0460	homoserine dehydrogenase
SB21_RS15275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB21_RS15280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SB21_RS15285	COG0647	UMP catabolic process
SB21_RS15290	COG2445	Protein of unknown function DUF86
SB21_RS15295	COG4470	Protein conserved in bacteria
SB21_RS15310	COG0739	heme binding
SB21_RS15320	COG0737	Belongs to the 5'-nucleotidase family
SB21_RS15325	COG0730	response to heat
SB21_RS15330	COG1801	Protein of unknown function DUF72
SB21_RS15345	COG2508	Transcriptional regulator
SB21_RS15370	COG2814	Major facilitator Superfamily
SB21_RS15375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB21_RS15380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB21_RS15385	COG2356	endonuclease I
SB21_RS15390	COG3842	ATPase activity
SB21_RS15395	COG2188	Transcriptional regulator
SB21_RS15400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB21_RS15405	COG0395	ABC-type sugar transport system, permease component
SB21_RS15410	COG1175	transmembrane transport
SB21_RS15425	COG0789	Transcriptional regulator
SB21_RS15450	COG0322	excinuclease ABC activity
SB21_RS15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB21_RS15460	COG2226	methyltransferase
SB21_RS15475	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS15480	COG0719	Fe-S assembly protein
SB21_RS15485	COG0822	iron-sulfur transferase activity
SB21_RS15490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB21_RS15495	COG0719	Fe-S assembly protein
SB21_RS15500	COG0396	ATPase activity
SB21_RS15510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SB21_RS15515	COG1464	Belongs to the NlpA lipoprotein family
SB21_RS15520	COG2011	ABC-type metal ion transport system permease component
SB21_RS15525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SB21_RS15535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB21_RS15540	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SB21_RS15555	COG1393	Belongs to the ArsC family
SB21_RS15560	COG1960	acyl-CoA dehydrogenase activity
SB21_RS15565	COG0183	Belongs to the thiolase family
SB21_RS15570	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB21_RS15570	COG1024	Enoyl-CoA hydratase
SB21_RS15590	COG5577	PFAM Coat F domain
SB21_RS15595	COG1846	Transcriptional regulator
SB21_RS15605	COG0583	DNA-binding transcription factor activity
SB21_RS15625	COG1120	ATPase activity
SB21_RS15640	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS15645	COG0783	Belongs to the Dps family
SB21_RS15650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB21_RS15660	COG0745	RESPONSE REGULATOR receiver
SB21_RS15665	COG2205	protein histidine kinase activity
SB21_RS15665	COG2770	Histidine kinase
SB21_RS15675	COG1309	transcriptional regulator
SB21_RS15680	COG0114	fumarate hydratase activity
SB21_RS15690	COG0697	spore germination
SB21_RS15695	COG0814	amino acid
SB21_RS15705	COG2197	response regulator
SB21_RS15710	COG4585	Histidine kinase
SB21_RS15715	COG4758	membrane
SB21_RS15720	COG3595	metallopeptidase activity
SB21_RS15725	COG1842	Phage shock protein A
SB21_RS15730	COG4758	membrane
SB21_RS15735	COG2814	Major facilitator Superfamily
SB21_RS15740	COG2096	Adenosyltransferase
SB21_RS15745	COG1120	ATPase activity
SB21_RS15750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS15755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB21_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS15765	COG3386	PFAM SMP-30 Gluconolaconase
SB21_RS15770	COG2205	protein histidine kinase activity
SB21_RS15775	COG0745	RESPONSE REGULATOR receiver
SB21_RS15785	COG1191	sigma factor activity
SB21_RS15795	COG2140	Oxalate decarboxylase
SB21_RS15805	COG1120	ATPase activity
SB21_RS15810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS15815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS15820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB21_RS15825	COG0531	amino acid
SB21_RS15840	COG1988	membrane-bound metal-dependent
SB21_RS15845	COG1368	sulfuric ester hydrolase activity
SB21_RS15850	COG1910	domain protein
SB21_RS15855	COG0725	ABC transporter, periplasmic molybdate-binding protein
SB21_RS15860	COG4149	molybdate abc transporter
SB21_RS15865	COG2197	response regulator
SB21_RS15870	COG3850	Histidine kinase
SB21_RS15875	COG1131	(ABC) transporter
SB21_RS15885	COG0842	Transport permease protein
SB21_RS15890	COG0656	L-ascorbic acid biosynthetic process
SB21_RS15915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB21_RS15920	COG3973	AAA domain
SB21_RS15925	COG2860	membrane
SB21_RS15935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SB21_RS15940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SB21_RS15945	COG2217	Heavy metal translocating P-type atpase
SB21_RS15955	COG2608	mercury ion transmembrane transporter activity
SB21_RS15960	COG1937	Protein conserved in bacteria
SB21_RS15965	COG0673	inositol 2-dehydrogenase activity
SB21_RS15975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB21_RS15980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SB21_RS15985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB21_RS15990	COG1126	abc transporter atp-binding protein
SB21_RS15995	COG0765	amino acid transport
SB21_RS16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS16010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB21_RS16015	COG0454	-acetyltransferase
SB21_RS16020	COG0583	DNA-binding transcription factor activity
SB21_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS16030	COG2732	(Barnase) inhibitor
SB21_RS16045	COG0557	exoribonuclease II activity
SB21_RS16050	COG1647	Serine aminopeptidase, S33
SB21_RS16055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB21_RS16060	COG1476	TRANSCRIPTIONal
SB21_RS16065	COG1396	sequence-specific DNA binding
SB21_RS16070	COG1396	sequence-specific DNA binding
SB21_RS16075	COG1733	regulation of RNA biosynthetic process
SB21_RS16100	COG1131	(ABC) transporter
SB21_RS16105	COG1174	glycine betaine transport
SB21_RS16110	COG1732	Glycine betaine
SB21_RS16115	COG1174	glycine betaine transport
SB21_RS16120	COG1125	glycine betaine transport
SB21_RS16120	COG0517	IMP dehydrogenase activity
SB21_RS16125	COG1510	regulation of RNA biosynthetic process
SB21_RS16135	COG1174	glycine betaine transport
SB21_RS16140	COG1732	Glycine betaine
SB21_RS16145	COG1174	glycine betaine transport
SB21_RS16150	COG0517	IMP dehydrogenase activity
SB21_RS16150	COG1125	glycine betaine transport
SB21_RS16155	COG1510	regulation of RNA biosynthetic process
SB21_RS16160	COG2095	MarC family integral membrane protein
SB21_RS16170	COG3064	Membrane
SB21_RS16175	COG4640	response to antibiotic
SB21_RS16180	COG0456	acetyltransferase
SB21_RS16195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB21_RS16215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB21_RS16220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB21_RS16230	COG2234	aminopeptidase activity
SB21_RS16250	COG0126	phosphoglycerate kinase activity
SB21_RS16260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB21_RS16265	COG2390	Transcriptional regulator
SB21_RS16270	COG2814	Major facilitator Superfamily
SB21_RS16275	COG1609	Transcriptional regulator
SB21_RS16290	COG0583	DNA-binding transcription factor activity
SB21_RS16295	COG0697	spore germination
SB21_RS16300	COG1113	amino acid transport
SB21_RS16320	COG0561	phosphatase activity
SB21_RS16325	COG1737	Transcriptional regulator
SB21_RS16330	COG1070	Carbohydrate kinase
SB21_RS16360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS16365	COG2186	Transcriptional regulator
SB21_RS16370	COG1620	l-lactate permease
SB21_RS16375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SB21_RS16385	COG5039	Polysaccharide pyruvyl transferase
SB21_RS16390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB21_RS16395	COG0110	maltose O-acetyltransferase activity
SB21_RS16400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SB21_RS16405	COG2244	polysaccharide biosynthetic process
SB21_RS16410	COG1216	Glycosyl transferase, family 2
SB21_RS16415	COG5039	Polysaccharide pyruvyl transferase
SB21_RS16420	COG1216	Glycosyl transferase, family 2
SB21_RS16430	COG0438	transferase activity, transferring glycosyl groups
SB21_RS16435	COG1215	transferase activity, transferring glycosyl groups
SB21_RS16450	COG0489	protein tyrosine kinase activity
SB21_RS16455	COG3944	biosynthesis protein
SB21_RS16460	COG1396	sequence-specific DNA binding
SB21_RS16465	COG2272	Belongs to the type-B carboxylesterase lipase family
SB21_RS16475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB21_RS16480	COG2364	Membrane
SB21_RS16485	COG0456	acetyltransferase
SB21_RS16490	COG3479	Phenolic acid decarboxylase
SB21_RS16545	COG2223	nitrite transmembrane transporter activity
SB21_RS16550	COG1609	Transcriptional regulator
SB21_RS16560	COG0583	DNA-binding transcription factor activity
SB21_RS16565	COG2828	Protein conserved in bacteria
SB21_RS16570	COG2814	Major facilitator Superfamily
SB21_RS16570	COG0477	Major facilitator Superfamily
SB21_RS16575	COG1611	Belongs to the LOG family
SB21_RS16580	COG1694	Mazg nucleotide pyrophosphohydrolase
SB21_RS16585	COG0659	secondary active sulfate transmembrane transporter activity
SB21_RS16590	COG0288	reversible hydration of carbon dioxide
SB21_RS16600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB21_RS16605	COG4290	ribonuclease
SB21_RS16610	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SB21_RS16615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS16625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SB21_RS16635	COG1051	belongs to the nudix hydrolase family
SB21_RS16640	COG0492	ferredoxin-NADP+ reductase activity
SB21_RS16645	COG3883	PFAM NLP P60 protein
SB21_RS16645	COG0791	NLP P60 protein
SB21_RS16650	COG0457	Tetratricopeptide repeat
SB21_RS16655	COG5002	protein histidine kinase activity
SB21_RS16660	COG0745	RESPONSE REGULATOR receiver
SB21_RS16665	COG1132	(ABC) transporter
SB21_RS16670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SB21_RS16670	COG0140	phosphoribosyl-ATP diphosphatase activity
SB21_RS16695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SB21_RS16710	COG4990	cell redox homeostasis
SB21_RS16715	COG0110	maltose O-acetyltransferase activity
SB21_RS16735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SB21_RS16745	COG2188	Transcriptional regulator
SB21_RS16750	COG1309	transcriptional regulator
SB21_RS16755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SB21_RS16760	COG1950	PFAM Membrane protein of
SB21_RS16765	COG1983	PspC domain protein
SB21_RS16770	COG3595	metallopeptidase activity
SB21_RS16785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SB21_RS16795	COG4897	Protein conserved in bacteria
SB21_RS16800	COG3848	Pyruvate phosphate dikinase
SB21_RS16800	COG0574	Belongs to the PEP-utilizing enzyme family
SB21_RS16805	COG1309	transcriptional regulator
SB21_RS16810	COG2814	Major facilitator Superfamily
SB21_RS16840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB21_RS16850	COG0793	Belongs to the peptidase S41A family
SB21_RS16850	COG3409	Peptidoglycan-binding domain 1 protein
SB21_RS16855	COG3420	alginic acid biosynthetic process
SB21_RS16860	COG2177	Part of the ABC transporter FtsEX involved in
SB21_RS16865	COG2884	Cell division ATP-binding protein ftsE
SB21_RS16870	COG2010	Cytochrome c
SB21_RS16875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS16890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SB21_RS16905	COG1516	flagellar protein fliS
SB21_RS16910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SB21_RS16915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB21_RS16935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB21_RS16940	COG4786	Flagellar basal body rod
SB21_RS16940	COG1256	bacterial-type flagellum assembly
SB21_RS16945	COG3418	PFAM FlgN family protein
SB21_RS16950	COG2747	anti-sigma28 factor FlgM
SB21_RS16960	COG1040	competence protein
SB21_RS16970	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SB21_RS16975	COG1307	EDD domain protein, DegV family
SB21_RS16980	COG2197	response regulator
SB21_RS16985	COG4585	Histidine kinase
SB21_RS16990	COG1739	Uncharacterized protein family UPF0029
SB21_RS16995	COG1316	TRANSCRIPTIONal
SB21_RS17000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB21_RS17005	COG0438	transferase activity, transferring glycosyl groups
SB21_RS17010	COG1215	transferase activity, transferring glycosyl groups
SB21_RS17015	COG3206	protein involved in exopolysaccharide biosynthesis
SB21_RS17020	COG3307	-O-antigen
SB21_RS17025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB21_RS17030	COG0297	glycogen (starch) synthase activity
SB21_RS17030	COG0438	transferase activity, transferring glycosyl groups
SB21_RS17035	COG2244	polysaccharide biosynthetic process
SB21_RS17045	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB21_RS17045	COG2247	cell wall binding repeat
SB21_RS17070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SB21_RS17075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB21_RS17080	COG1134	teichoic acid transport
SB21_RS17085	COG1682	transport, permease protein
SB21_RS17090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB21_RS17100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SB21_RS17105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SB21_RS17115	COG4193	domain, Protein
SB21_RS17120	COG1482	cell wall glycoprotein biosynthetic process
SB21_RS17130	COG0814	amino acid
SB21_RS17140	COG1215	transferase activity, transferring glycosyl groups
SB21_RS17145	COG2814	Major facilitator Superfamily
SB21_RS17150	COG1316	TRANSCRIPTIONal
SB21_RS17155	COG0561	phosphatase activity
SB21_RS17160	COG2433	Pfam Transposase IS66
SB21_RS17165	COG0791	NLP P60 protein
SB21_RS17175	COG2843	Capsule synthesis protein
SB21_RS17185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SB21_RS17195	COG0697	spore germination
SB21_RS17200	COG0814	amino acid
SB21_RS17210	COG1609	Transcriptional regulator
SB21_RS17215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB21_RS17225	COG1129	ABC transporter
SB21_RS17230	COG1172	Belongs to the binding-protein-dependent transport system permease family
SB21_RS17235	COG1879	ABC-type sugar transport system periplasmic component
SB21_RS17240	COG3103	Sh3 type 3 domain protein
SB21_RS17245	COG2249	NAD(P)H dehydrogenase (quinone) activity
SB21_RS17255	COG3527	Alpha-acetolactate decarboxylase
SB21_RS17260	COG0028	Belongs to the TPP enzyme family
SB21_RS17265	COG0583	DNA-binding transcription factor activity
SB21_RS17270	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SB21_RS17285	COG5337	Spore coat protein CotH
SB21_RS17295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SB21_RS17310	COG1522	sequence-specific DNA binding
SB21_RS17315	COG2059	Chromate
SB21_RS17320	COG2059	Chromate
SB21_RS17350	COG5444	nuclease activity
SB21_RS17365	COG3878	Protein conserved in bacteria
SB21_RS17370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB21_RS17375	COG4464	protein tyrosine phosphatase activity
SB21_RS17380	COG0489	protein tyrosine kinase activity
SB21_RS17385	COG3944	biosynthesis protein
SB21_RS17400	COG4715	Zinc finger, swim domain protein
SB21_RS17405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB21_RS17410	COG0561	phosphatase activity
SB21_RS17415	COG1349	DNA-binding transcription factor activity
SB21_RS17420	COG0629	single-stranded DNA binding
SB21_RS17445	COG0457	Tetratricopeptide repeat
SB21_RS17450	COG4786	Flagellar basal body rod
SB21_RS17455	COG4786	Flagellar basal body rod
SB21_RS17460	COG1077	Cell shape determining protein MreB Mrl
SB21_RS17465	COG1609	Transcriptional regulator
SB21_RS17470	COG1846	Transcriptional regulator
SB21_RS17475	COG2814	Major facilitator Superfamily
SB21_RS17480	COG1953	Uracil, thiamine, allantoin
SB21_RS17485	COG0477	Major facilitator Superfamily
SB21_RS17490	COG1335	isochorismatase
SB21_RS17495	COG0004	ammonium transporteR
SB21_RS17500	COG0347	Belongs to the P(II) protein family
SB21_RS17505	COG0772	Belongs to the SEDS family
SB21_RS17510	COG0671	phosphoesterase, PA-phosphatase related
SB21_RS17520	COG0739	heme binding
SB21_RS17525	COG1247	-acetyltransferase
SB21_RS17540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB21_RS17555	COG0726	polysaccharide deacetylase
SB21_RS17560	COG1959	2 iron, 2 sulfur cluster binding
SB21_RS17575	COG0831	urea catabolic process
SB21_RS17580	COG3237	CsbD-like
SB21_RS17585	COG1994	Peptidase M50
SB21_RS17590	COG0457	Tetratricopeptide repeat
SB21_RS17600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SB21_RS17605	COG2304	oxidoreductase activity
SB21_RS17610	COG2304	oxidoreductase activity
SB21_RS17620	COG2385	sporulation resulting in formation of a cellular spore
SB21_RS17625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB21_RS17635	COG4836	Membrane
SB21_RS17705	COG0698	ribose 5-phosphate isomerase
SB21_RS17710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SB21_RS17720	COG0009	L-threonylcarbamoyladenylate synthase
SB21_RS17725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SB21_RS17745	COG2890	protein-(glutamine-N5) methyltransferase activity
SB21_RS17750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SB21_RS17755	COG0346	lactoylglutathione lyase activity
SB21_RS17760	COG0789	Transcriptional regulator
SB21_RS17765	COG0679	Auxin Efflux Carrier
SB21_RS17770	COG0281	malic enzyme
SB21_RS17785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SB21_RS17790	COG1494	fructose-1,6-bisphosphatase
SB21_RS17795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB21_RS17805	COG0191	fructose-bisphosphate aldolase activity
SB21_RS17810	COG2204	response regulator
SB21_RS17815	COG4821	SIS domain
SB21_RS17830	COG0247	lactate metabolic process
SB21_RS17830	COG2181	nitrate reductase activity
SB21_RS17835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB21_RS17850	COG1132	(ABC) transporter
SB21_RS17855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB21_RS17865	COG2181	nitrate reductase activity
SB21_RS17870	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SB21_RS17875	COG1140	nitrate reductase beta subunit
SB21_RS17880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SB21_RS17885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB21_RS17895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB21_RS17900	COG2223	nitrite transmembrane transporter activity
SB21_RS17910	COG4506	Protein conserved in bacteria
SB21_RS17920	COG3391	amine dehydrogenase activity
SB21_RS17925	COG3391	amine dehydrogenase activity
SB21_RS17935	COG0457	Tetratricopeptide repeat
SB21_RS17980	COG0010	Belongs to the arginase family
SB21_RS17985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SB21_RS18005	COG1994	Peptidase M50
SB21_RS18010	COG1942	4-Oxalocrotonate Tautomerase
SB21_RS18015	COG1846	Transcriptional regulator
SB21_RS18030	COG3465	dGTPase activity
SB21_RS18035	COG1078	dGTPase activity
SB21_RS18050	COG1695	Transcriptional regulator
SB21_RS18060	COG1131	(ABC) transporter
SB21_RS18065	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB21_RS18095	COG0583	DNA-binding transcription factor activity
SB21_RS18100	COG2855	membrane
SB21_RS18105	COG0280	phosphate acetyltransferase
SB21_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS18120	COG0436	Aminotransferase
SB21_RS18150	COG2814	Major facilitator Superfamily
SB21_RS18155	COG2814	Major facilitator Superfamily
SB21_RS18160	COG0833	amino acid
SB21_RS18165	COG4187	Peptidase family M20/M25/M40
SB21_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS18175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB21_RS18185	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SB21_RS18190	COG1091	dTDP-4-dehydrorhamnose reductase activity
SB21_RS18195	COG1088	dTDP-glucose 4,6-dehydratase activity
SB21_RS18200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SB21_RS18210	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SB21_RS18215	COG2089	acid synthase
SB21_RS18220	COG0456	acetyltransferase
SB21_RS18225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SB21_RS18230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB21_RS18235	COG0463	Glycosyl transferase, family 2
SB21_RS18245	COG2363	Small membrane protein
SB21_RS18250	COG2233	PERMEase
SB21_RS18265	COG1216	Glycosyl transferase, family 2
SB21_RS18280	COG1695	Transcriptional regulator
SB21_RS18285	COG0351	phosphomethylpyrimidine kinase
SB21_RS18295	COG1621	beta-fructofuranosidase activity
SB21_RS18305	COG3711	transcriptional antiterminator
SB21_RS18315	COG1404	Belongs to the peptidase S8 family
SB21_RS18320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB21_RS18325	COG0778	Nitroreductase
SB21_RS18330	COG0772	Belongs to the SEDS family
SB21_RS18335	COG0454	-acetyltransferase
SB21_RS18355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SB21_RS18360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB21_RS18365	COG2261	transglycosylase associated protein
SB21_RS18370	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB21_RS18375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SB21_RS18380	COG2246	polysaccharide biosynthetic process
SB21_RS18385	COG1309	transcriptional regulator
SB21_RS18405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB21_RS18410	COG2837	iron assimilation
SB21_RS18415	COG2822	iron ion transport
SB21_RS18430	COG0583	DNA-binding transcription factor activity
SB21_RS18440	COG1346	cytolysis
SB21_RS18445	COG4895	conserved protein (DUF2196)
SB21_RS18450	COG0789	Transcriptional regulator
SB21_RS18455	COG5504	Zn-dependent protease
SB21_RS18460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SB21_RS18465	COG0346	lactoylglutathione lyase activity
SB21_RS18470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS18475	COG1404	Belongs to the peptidase S8 family
SB21_RS18480	COG1442	glycosyl transferase family 8
SB21_RS18485	COG2357	RelA SpoT domain protein
SB21_RS18490	COG1575	Belongs to the MenA family. Type 1 subfamily
SB21_RS18515	COG1696	Membrane protein involved in D-alanine export
SB21_RS18525	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SB21_RS18530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB21_RS18535	COG1486	melibiose metabolic process
SB21_RS18545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS18550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS18555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB21_RS18555	COG3711	transcriptional antiterminator
SB21_RS18575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS18580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB21_RS18590	COG0640	Transcriptional regulator
SB21_RS18595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SB21_RS18600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS18605	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB21_RS18610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB21_RS18615	COG2723	6-phospho-beta-galactosidase activity
SB21_RS18620	COG1940	carbohydrate kinase activity
SB21_RS18625	COG1482	cell wall glycoprotein biosynthetic process
SB21_RS18635	COG0753	catalase activity
SB21_RS18640	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SB21_RS18645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB21_RS18650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SB21_RS18655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SB21_RS18660	COG4988	ABC transporter
SB21_RS18665	COG1294	oxidase, subunit
SB21_RS18670	COG1271	oxidase subunit
SB21_RS18675	COG3493	citrate carrier protein
SB21_RS18680	COG0726	polysaccharide deacetylase
SB21_RS18685	COG3842	ATPase activity
SB21_RS18695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS18705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB21_RS18715	COG4894	glucomannan catabolic process
SB21_RS18720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB21_RS18725	COG0500	methyltransferase
SB21_RS18730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB21_RS18745	COG0753	catalase activity
SB21_RS18745	COG0693	protein deglycase activity
SB21_RS18750	COG2851	Citrate transporter
SB21_RS18755	COG2273	Hydrolase Family 16
SB21_RS18760	COG3711	transcriptional antiterminator
SB21_RS18765	COG2270	Major facilitator Superfamily
SB21_RS18770	COG0513	Belongs to the DEAD box helicase family
SB21_RS18795	COG3209	COG3209 Rhs family protein
SB21_RS18805	COG0697	spore germination
SB21_RS18810	COG0589	response to stress
SB21_RS18815	COG2723	6-phospho-beta-galactosidase activity
SB21_RS18820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB21_RS18820	COG2190	(PTS) system
SB21_RS18820	COG1263	PTS System
SB21_RS18835	COG3507	Belongs to the glycosyl hydrolase 43 family
SB21_RS18860	COG0010	Belongs to the arginase family
SB21_RS18865	COG0833	amino acid
SB21_RS18870	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SB21_RS18875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB21_RS18885	COG2390	Transcriptional regulator
SB21_RS18890	COG0561	phosphatase activity
SB21_RS18920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB21_RS18925	COG5294	Protein conserved in bacteria
SB21_RS18930	COG0577	efflux transmembrane transporter activity
SB21_RS18935	COG1136	(ABC) transporter
SB21_RS18940	COG2205	protein histidine kinase activity
SB21_RS18945	COG0745	RESPONSE REGULATOR receiver
SB21_RS18960	COG1082	Xylose isomerase domain protein TIM barrel
SB21_RS18970	COG2814	Major facilitator Superfamily
SB21_RS19000	COG1349	DNA-binding transcription factor activity
SB21_RS19005	COG0667	Aldo Keto reductase
SB21_RS19010	COG2814	Major facilitator Superfamily
SB21_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS19030	COG2197	response regulator
SB21_RS19035	COG4585	Histidine kinase
SB21_RS19040	COG3239	Fatty acid desaturase
SB21_RS19050	COG1309	transcriptional regulator
SB21_RS19055	COG1012	belongs to the aldehyde dehydrogenase family
SB21_RS19060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SB21_RS19070	COG0640	Transcriptional regulator
SB21_RS19075	COG2814	Major facilitator Superfamily
SB21_RS19080	COG1714	RDD family
SB21_RS19090	COG0450	alkyl hydroperoxide reductase
SB21_RS19095	COG3634	alkyl hydroperoxide reductase activity
SB21_RS19100	COG3177	Filamentation induced by cAMP protein fic
SB21_RS19105	COG1113	amino acid transport
SB21_RS19115	COG2080	2 iron, 2 sulfur cluster binding
SB21_RS19130	COG2068	MobA-Related Protein
SB21_RS19135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SB21_RS19185	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
SB21_RS19190	COG0667	Aldo Keto reductase
SB21_RS19195	COG0456	acetyltransferase
SB21_RS19200	COG0457	Tetratricopeptide repeat
SB21_RS19205	COG0010	Belongs to the arginase family
SB21_RS19210	COG0833	amino acid
SB21_RS19215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB21_RS19220	COG5658	integral membrane protein
SB21_RS19225	COG0640	Transcriptional regulator
SB21_RS19230	COG3829	transcription factor binding
SB21_RS19240	COG0488	(ABC) transporter
SB21_RS19255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB21_RS19260	COG5002	protein histidine kinase activity
SB21_RS19260	COG3850	Histidine kinase
SB21_RS19265	COG0745	RESPONSE REGULATOR receiver
SB21_RS19280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB21_RS19285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SB21_RS19290	COG4853	Protein conserved in bacteria
SB21_RS19295	COG4863	YycH protein
SB21_RS19300	COG5002	protein histidine kinase activity
SB21_RS19305	COG0745	RESPONSE REGULATOR receiver
SB21_RS19340	COG0346	lactoylglutathione lyase activity
SB21_RS19345	COG0305	Participates in initiation and elongation during chromosome replication
SB21_RS19365	COG3093	addiction module antidote protein HigA
SB21_RS19370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SB21_RS19375	COG0297	glycogen (starch) synthase activity
SB21_RS19385	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SB21_RS19390	COG0438	transferase activity, transferring glycosyl groups
SB21_RS19410	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SB21_RS19415	COG4241	membrane
SB21_RS19425	COG5577	PFAM Coat F domain
SB21_RS19430	COG1733	regulation of RNA biosynthetic process
SB21_RS19440	COG0697	spore germination
SB21_RS19445	COG1621	beta-fructofuranosidase activity
SB21_RS19450	COG1621	beta-fructofuranosidase activity
SB21_RS19455	COG1802	Transcriptional regulator
SB21_RS19460	COG2318	DinB family
SB21_RS19465	COG2211	Major facilitator Superfamily
SB21_RS19470	COG0583	DNA-binding transcription factor activity
SB21_RS19485	COG0778	Nitroreductase
SB21_RS19490	COG1846	Transcriptional regulator
SB21_RS19495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB21_RS19500	COG1846	Transcriptional regulator
SB21_RS19505	COG2153	protein acetylation
SB21_RS19515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SB21_RS19520	COG0583	DNA-binding transcription factor activity
SB21_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
SB21_RS19530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB21_RS19535	COG0697	spore germination
SB21_RS19540	COG1331	Highly conserved protein containing a thioredoxin domain
SB21_RS19545	COG1266	CAAX protease self-immunity
SB21_RS19555	COG0346	lactoylglutathione lyase activity
SB21_RS19560	COG1609	Transcriptional regulator
SB21_RS19565	COG0708	Exodeoxyribonuclease III
SB21_RS19570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB21_RS19575	COG2169	Transcriptional regulator
SB21_RS19585	COG0629	single-stranded DNA binding
SB21_RS19595	COG0012	GTP binding
SB21_RS19600	COG0243	molybdopterin cofactor binding
SB21_RS19605	COG4481	Protein conserved in bacteria
SB21_RS19610	COG3949	Membrane
SB21_RS19625	COG1475	DNA binding
SB21_RS19630	COG1192	Involved in chromosome partitioning
SB21_RS19655	COG1847	R3H domain protein
SB21_RS19660	COG0706	membrane insertase activity