locus-tag	class	description
A8142_RS00020	COG0517	IMP dehydrogenase activity
A8142_RS00020	COG0516	GMP reductase activity
A8142_RS00025	COG1686	Belongs to the peptidase S11 family
A8142_RS00045	COG1929	Belongs to the glycerate kinase type-1 family
A8142_RS00055	COG1428	Deoxynucleoside kinase
A8142_RS00060	COG1428	Deoxynucleoside kinase
A8142_RS00065	COG3858	chitin binding
A8142_RS00065	COG1388	LysM domain
A8142_RS00070	COG1335	isochorismatase
A8142_RS00075	COG0590	tRNA wobble adenosine to inosine editing
A8142_RS00085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8142_RS00090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8142_RS00095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8142_RS00140	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
A8142_RS00145	COG3853	Toxic anion resistance protein (TelA)
A8142_RS00150	COG1982	Orn Lys Arg decarboxylase major
A8142_RS00160	COG3870	Protein conserved in bacteria
A8142_RS00165	COG1728	Protein conserved in bacteria
A8142_RS00170	COG0470	DNA polymerase III
A8142_RS00175	COG1774	PSP1 C-terminal conserved region
A8142_RS00185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8142_RS00195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8142_RS00200	COG2002	toxin-antitoxin pair type II binding
A8142_RS00205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8142_RS00205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8142_RS00210	COG0084	hydrolase, TatD family'
A8142_RS00215	COG3584	3D domain protein
A8142_RS00215	COG3583	domain protein
A8142_RS00220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8142_RS00225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8142_RS00235	COG4466	Protein conserved in bacteria
A8142_RS00250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8142_RS00255	COG0251	oxidation-reduction process
A8142_RS00270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8142_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8142_RS00295	COG2002	toxin-antitoxin pair type II binding
A8142_RS00300	COG2244	polysaccharide biosynthetic process
A8142_RS00305	COG3956	TIGRFAM MazG family protein
A8142_RS00310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8142_RS00325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8142_RS00330	COG1098	S1 RNA binding domain
A8142_RS00345	COG2208	phosphoserine phosphatase activity
A8142_RS00350	COG2304	oxidoreductase activity
A8142_RS00355	COG0515	serine threonine protein kinase
A8142_RS00360	COG0037	tRNA processing
A8142_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8142_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8142_RS00385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8142_RS00390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8142_RS00395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8142_RS00400	COG0512	Glutamine amidotransferase of anthranilate synthase
A8142_RS00405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8142_RS00410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8142_RS00415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8142_RS00420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8142_RS00425	COG1396	sequence-specific DNA binding
A8142_RS00430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8142_RS00435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8142_RS00455	COG4463	regulation of RNA biosynthetic process
A8142_RS00460	COG3880	PFAM UvrB UvrC protein
A8142_RS00470	COG0542	response to heat
A8142_RS00475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A8142_RS00480	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A8142_RS00485	COG4956	integral membrane protein (PIN domain superfamily)
A8142_RS00505	COG1045	serine acetyltransferase
A8142_RS00515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A8142_RS00520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8142_RS00525	COG3688	RNA-binding protein containing a PIN domain
A8142_RS00530	COG1595	DNA-templated transcription, initiation
A8142_RS00540	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8142_RS00545	COG0250	Participates in transcription elongation, termination and antitermination
A8142_RS00570	COG2813	Specifically methylates the guanine in position
A8142_RS00585	COG1358	cellular component organization or biogenesis
A8142_RS00610	COG0596	Alpha beta hydrolase
A8142_RS00700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8142_RS00715	COG0201	protein transport
A8142_RS00725	COG0024	Methionine aminopeptidase
A8142_RS00735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8142_RS00760	COG1122	ATPase activity
A8142_RS00765	COG1122	ATPase activity
A8142_RS00770	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8142_RS00790	COG2226	methyltransferase
A8142_RS00795	COG2318	DinB family
A8142_RS00805	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS00810	COG0489	protein tyrosine kinase activity
A8142_RS00820	COG2194	sulfuric ester hydrolase activity
A8142_RS00825	COG0726	polysaccharide deacetylase
A8142_RS00845	COG0738	Major facilitator superfamily
A8142_RS00850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8142_RS00860	COG1063	alcohol dehydrogenase
A8142_RS00865	COG0659	secondary active sulfate transmembrane transporter activity
A8142_RS00870	COG0385	Bile acid
A8142_RS00875	COG2819	hydrolase of the alpha beta superfamily
A8142_RS00880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS00885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS00890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8142_RS00895	COG2207	Transcriptional regulator
A8142_RS00895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8142_RS00900	COG3876	Protein conserved in bacteria
A8142_RS00905	COG1472	Belongs to the glycosyl hydrolase 3 family
A8142_RS00910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8142_RS00915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS00915	COG1263	PTS System
A8142_RS00925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8142_RS00930	COG1683	Conserved Protein
A8142_RS00960	COG1595	DNA-templated transcription, initiation
A8142_RS00965	COG5662	AntiSigma factor
A8142_RS00970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8142_RS00975	COG4856	YbbR-like protein
A8142_RS01005	COG5002	protein histidine kinase activity
A8142_RS01010	COG1136	(ABC) transporter
A8142_RS01015	COG0577	efflux transmembrane transporter activity
A8142_RS01020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8142_RS01030	COG1346	cytolysis
A8142_RS01035	COG1380	Effector of murein hydrolase LrgA
A8142_RS01040	COG1846	Transcriptional regulator
A8142_RS01045	COG1113	amino acid transport
A8142_RS01050	COG1011	Hydrolase
A8142_RS01055	COG4585	Histidine kinase
A8142_RS01060	COG2197	response regulator
A8142_RS01065	COG1131	(ABC) transporter
A8142_RS01105	COG0531	amino acid
A8142_RS01110	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A8142_RS01125	COG0584	glycerophosphoryl diester phosphodiesterase
A8142_RS01130	COG2271	Major facilitator Superfamily
A8142_RS01140	COG2368	4-hydroxyphenylacetate
A8142_RS01150	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS01165	COG1397	ADP-ribosylglycohydrolase
A8142_RS01170	COG5444	nuclease activity
A8142_RS01180	COG0371	Dehydrogenase
A8142_RS01190	COG1183	phosphatidylcholine synthase activity
A8142_RS01195	COG0586	Pfam SNARE associated Golgi protein
A8142_RS01200	COG0688	phosphatidylethanolamine metabolic process
A8142_RS01215	COG1301	dicarboxylic acid transport
A8142_RS01220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8142_RS01225	COG0833	amino acid
A8142_RS01230	COG2040	homocysteine
A8142_RS01235	COG1115	amino acid carrier protein
A8142_RS01240	COG2066	Belongs to the glutaminase family
A8142_RS01245	COG4191	Histidine kinase
A8142_RS01250	COG0784	Response regulator, receiver
A8142_RS01255	COG3173	Aminoglycoside phosphotransferase
A8142_RS01270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8142_RS01275	COG0778	Nitroreductase
A8142_RS01280	COG0346	lactoylglutathione lyase activity
A8142_RS01285	COG2259	Doxx family
A8142_RS01290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS01305	COG3773	Cell wall hydrolase
A8142_RS01310	COG3540	Alkaline phosphatase
A8142_RS01315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8142_RS01320	COG0805	protein transport
A8142_RS01330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8142_RS01335	COG0477	Major facilitator Superfamily
A8142_RS01340	COG1309	transcriptional regulator
A8142_RS01345	COG0252	asparaginase activity
A8142_RS01350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A8142_RS01355	COG1405	negative regulation of cell septum assembly
A8142_RS01355	COG3012	SEC-C Motif Domain Protein
A8142_RS01370	COG1595	DNA-templated transcription, initiation
A8142_RS01375	COG1595	DNA-templated transcription, initiation
A8142_RS01380	COG1876	peptidase activity
A8142_RS01385	COG0457	Tetratricopeptide repeat
A8142_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS01395	COG0366	Alpha amylase catalytic
A8142_RS01400	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8142_RS01405	COG1121	(ABC) transporter
A8142_RS01410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8142_RS01415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS01420	COG2310	stress, protein
A8142_RS01425	COG2310	stress, protein
A8142_RS01430	COG2310	stress, protein
A8142_RS01435	COG0861	Integral membrane protein TerC family
A8142_RS01445	COG3853	Toxic anion resistance protein (TelA)
A8142_RS01450	COG0477	Major facilitator Superfamily
A8142_RS01455	COG0517	IMP dehydrogenase activity
A8142_RS01455	COG4175	Glycine betaine
A8142_RS01460	COG4176	ABC-type proline glycine betaine transport system permease component
A8142_RS01465	COG2113	Glycine betaine
A8142_RS01470	COG1473	amidohydrolase
A8142_RS01475	COG1288	antiporter activity
A8142_RS01495	COG2814	Major facilitator Superfamily
A8142_RS01500	COG1846	Transcriptional regulator
A8142_RS01505	COG1280	lysine exporter protein (LysE YggA)
A8142_RS01510	COG3403	YqcI/YcgG family
A8142_RS01515	COG1113	amino acid transport
A8142_RS01520	COG3665	Urea carboxylase-associated protein
A8142_RS01535	COG1660	Displays ATPase and GTPase activities
A8142_RS01540	COG1082	Xylose isomerase domain protein TIM barrel
A8142_RS01545	COG2271	Major facilitator Superfamily
A8142_RS01550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8142_RS01555	COG3458	cephalosporin-C deacetylase activity
A8142_RS01560	COG3541	Predicted nucleotidyltransferase
A8142_RS01565	COG0506	proline dehydrogenase activity
A8142_RS01570	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS01575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8142_RS01580	COG2508	Transcriptional regulator
A8142_RS01590	COG1587	Uroporphyrinogen-III synthase
A8142_RS01590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8142_RS01595	COG2146	nitrite reductase [NAD(P)H] activity
A8142_RS01600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8142_RS01605	COG0243	molybdopterin cofactor binding
A8142_RS01610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8142_RS01615	COG2223	nitrite transmembrane transporter activity
A8142_RS01620	COG0523	cobalamin synthesis protein
A8142_RS01625	COG1063	alcohol dehydrogenase
A8142_RS01630	COG1714	RDD family
A8142_RS01640	COG2723	6-phospho-beta-galactosidase activity
A8142_RS01650	COG3209	COG3209 Rhs family protein
A8142_RS01655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A8142_RS01660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A8142_RS01665	COG1733	regulation of RNA biosynthetic process
A8142_RS01675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS01680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS01685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS01690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A8142_RS01705	COG2364	Membrane
A8142_RS01710	COG1126	abc transporter atp-binding protein
A8142_RS01715	COG0765	amino acid transport
A8142_RS01725	COG0583	DNA-binding transcription factor activity
A8142_RS01730	COG0163	prenyltransferase activity
A8142_RS01735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8142_RS01750	COG3104	oligopeptide transport
A8142_RS01755	COG5434	Belongs to the glycosyl hydrolase 28 family
A8142_RS01765	COG0697	spore germination
A8142_RS01775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8142_RS01780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS01785	COG0456	acetyltransferase
A8142_RS01790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8142_RS01795	COG0765	amino acid transport
A8142_RS01800	COG1126	abc transporter atp-binding protein
A8142_RS01805	COG1473	amidohydrolase
A8142_RS01810	COG2079	MmgE PrpD family protein
A8142_RS01815	COG1136	(ABC) transporter
A8142_RS01820	COG0577	efflux transmembrane transporter activity
A8142_RS01825	COG0745	RESPONSE REGULATOR receiver
A8142_RS01830	COG3850	Histidine kinase
A8142_RS01830	COG5002	protein histidine kinase activity
A8142_RS01835	COG0457	Tetratricopeptide repeat
A8142_RS01850	COG0527	aspartate kinase activity
A8142_RS01855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS01860	COG4605	iron ion homeostasis
A8142_RS01865	COG4604	ABC transporter, ATP-binding protein
A8142_RS01870	COG4607	ABC-type enterochelin transport system periplasmic component
A8142_RS01875	COG2814	Major facilitator Superfamily
A8142_RS01880	COG1309	transcriptional regulator
A8142_RS01885	COG0778	Nitroreductase
A8142_RS01890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A8142_RS01895	COG0640	Transcriptional regulator
A8142_RS01900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8142_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS01915	COG4975	Glucose uptake
A8142_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS01925	COG4549	nuclear export factor GLE1
A8142_RS01930	COG2372	response to copper ion
A8142_RS01930	COG1276	copper resistance
A8142_RS01935	COG1349	DNA-binding transcription factor activity
A8142_RS01945	COG2213	PTS system mannitol-specific
A8142_RS01950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS01960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8142_RS01965	COG0561	phosphatase activity
A8142_RS01975	COG1914	H( )-stimulated, divalent metal cation uptake system
A8142_RS01985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8142_RS01990	COG1984	allophanate hydrolase subunit 2
A8142_RS01995	COG1414	Transcriptional regulator
A8142_RS02000	COG2755	lipolytic protein G-D-S-L family
A8142_RS02010	COG2329	Antibiotic biosynthesis monooxygenase
A8142_RS02015	COG0768	penicillin binding
A8142_RS02020	COG4989	oxidoreductase activity
A8142_RS02025	COG3711	transcriptional antiterminator
A8142_RS02030	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS02040	COG1917	Cupin 2, conserved barrel domain protein
A8142_RS02045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8142_RS02050	COG3871	stress protein (general stress protein 26)
A8142_RS02060	COG2814	Major facilitator Superfamily
A8142_RS02065	COG1522	sequence-specific DNA binding
A8142_RS02070	COG0551	DNA topoisomerase type I activity
A8142_RS02070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8142_RS02075	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A8142_RS02080	COG3706	GGDEF domain
A8142_RS02085	COG5298	Protein conserved in bacteria
A8142_RS02090	COG1215	transferase activity, transferring glycosyl groups
A8142_RS02100	COG0531	amino acid
A8142_RS02110	COG0028	Belongs to the TPP enzyme family
A8142_RS02115	COG1388	LysM domain
A8142_RS02115	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS02115	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8142_RS02135	COG0457	Tetratricopeptide repeat
A8142_RS02165	COG1914	H( )-stimulated, divalent metal cation uptake system
A8142_RS02180	COG4876	unkown
A8142_RS02190	COG2076	Multidrug Resistance protein
A8142_RS02195	COG2217	Heavy metal translocating P-type atpase
A8142_RS02200	COG3729	General stress protein
A8142_RS02205	COG0662	Cupin 2, conserved barrel domain protein
A8142_RS02210	COG2329	Antibiotic biosynthesis monooxygenase
A8142_RS02215	COG3546	catalase activity
A8142_RS02220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8142_RS02225	COG3290	protein histidine kinase activity
A8142_RS02230	COG4565	transcriptional regulatory protein
A8142_RS02235	COG1301	dicarboxylic acid transport
A8142_RS02240	COG0628	permease
A8142_RS02245	COG1131	(ABC) transporter
A8142_RS02250	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8142_RS02260	COG1960	acyl-CoA dehydrogenase activity
A8142_RS02275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8142_RS02280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS02290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8142_RS02295	COG0513	Belongs to the DEAD box helicase family
A8142_RS02300	COG3402	PFAM membrane-flanked domain
A8142_RS02305	COG3428	Bacterial PH domain
A8142_RS02310	COG0705	Rhomboid family
A8142_RS02320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8142_RS02325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8142_RS02330	COG0864	Transcriptional regulator
A8142_RS02335	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8142_RS02340	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS02345	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS02350	COG2172	sigma factor antagonist activity
A8142_RS02355	COG2208	phosphoserine phosphatase activity
A8142_RS02360	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS02370	COG1191	sigma factor activity
A8142_RS02375	COG2208	phosphoserine phosphatase activity
A8142_RS02380	COG2183	response to ionizing radiation
A8142_RS02445	COG5444	nuclease activity
A8142_RS02450	COG0457	Tetratricopeptide repeat
A8142_RS02455	COG0477	Major facilitator Superfamily
A8142_RS02470	COG2030	dehydratase
A8142_RS02480	COG1959	2 iron, 2 sulfur cluster binding
A8142_RS02485	COG2910	NAD(P)H-binding
A8142_RS02495	COG1278	Cold shock
A8142_RS02500	COG1329	Transcriptional regulator
A8142_RS02505	COG1937	Protein conserved in bacteria
A8142_RS02510	COG2210	Belongs to the sulfur carrier protein TusA family
A8142_RS02515	COG1054	Belongs to the UPF0176 family
A8142_RS02520	COG0425	Belongs to the sulfur carrier protein TusA family
A8142_RS02520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8142_RS02525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS02525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8142_RS02530	COG0425	Belongs to the sulfur carrier protein TusA family
A8142_RS02535	COG0730	response to heat
A8142_RS02540	COG1794	racemase activity, acting on amino acids and derivatives
A8142_RS02555	COG3621	Patatin-like phospholipase
A8142_RS02565	COG0662	Cupin 2, conserved barrel domain protein
A8142_RS02580	COG0277	FAD linked oxidase domain protein
A8142_RS02600	COG0662	Cupin 2, conserved barrel domain protein
A8142_RS02605	COG2318	DinB family
A8142_RS02640	COG1064	alcohol dehydrogenase
A8142_RS02645	COG0789	Transcriptional regulator
A8142_RS02655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS02670	COG2814	Major facilitator Superfamily
A8142_RS02675	COG1309	transcriptional regulator
A8142_RS02680	COG0697	spore germination
A8142_RS02685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS02690	COG5577	PFAM Coat F domain
A8142_RS02700	COG1063	alcohol dehydrogenase
A8142_RS02705	COG5577	PFAM Coat F domain
A8142_RS02715	COG4585	Histidine kinase
A8142_RS02720	COG2197	response regulator
A8142_RS02725	COG2409	Drug exporters of the RND superfamily
A8142_RS02730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8142_RS02735	COG0488	(ABC) transporter
A8142_RS02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8142_RS02745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS02755	COG2814	Major facilitator Superfamily
A8142_RS02760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8142_RS02770	COG0730	response to heat
A8142_RS02775	COG0456	acetyltransferase
A8142_RS02780	COG0789	Transcriptional regulator
A8142_RS02780	COG4978	Transcriptional regulator
A8142_RS02785	COG0697	spore germination
A8142_RS02790	COG1051	belongs to the nudix hydrolase family
A8142_RS02795	COG2226	methyltransferase
A8142_RS02800	COG0473	3-isopropylmalate dehydrogenase activity
A8142_RS02805	COG1802	Transcriptional regulator
A8142_RS02810	COG1819	glycosyl
A8142_RS02825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8142_RS02830	COG1388	LysM domain
A8142_RS02835	COG2814	Major facilitator Superfamily
A8142_RS02840	COG2188	Transcriptional regulator
A8142_RS02845	COG2186	Transcriptional regulator
A8142_RS02850	COG2807	transmembrane transport
A8142_RS02855	COG2076	Multidrug Resistance protein
A8142_RS02860	COG2076	Multidrug Resistance protein
A8142_RS02865	COG1309	transcriptional regulator
A8142_RS02870	COG0531	amino acid
A8142_RS02880	COG3832	glyoxalase III activity
A8142_RS02885	COG0604	alcohol dehydrogenase
A8142_RS02890	COG2814	Major facilitator Superfamily
A8142_RS02930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A8142_RS02935	COG0802	atpase or kinase
A8142_RS02940	COG1214	PFAM Peptidase M22, glycoprotease
A8142_RS02945	COG0456	acetyltransferase
A8142_RS02950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8142_RS02955	COG0488	(ABC) transporter
A8142_RS02970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8142_RS02975	COG0805	protein transport
A8142_RS02985	COG1266	CAAX protease self-immunity
A8142_RS03025	COG0457	Tetratricopeptide repeat
A8142_RS03030	COG1063	alcohol dehydrogenase
A8142_RS03035	COG2211	Major facilitator Superfamily
A8142_RS03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8142_RS03050	COG1842	Phage shock protein A
A8142_RS03055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8142_RS03060	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A8142_RS03065	COG4260	virion core protein, lumpy skin disease virus
A8142_RS03070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A8142_RS03070	COG2755	lipolytic protein G-D-S-L family
A8142_RS03080	COG1595	DNA-templated transcription, initiation
A8142_RS03085	COG1063	alcohol dehydrogenase
A8142_RS03090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8142_RS03095	COG0823	Involved in the tonB-independent uptake of proteins
A8142_RS03105	COG2132	Multicopper oxidase
A8142_RS03110	COG1113	amino acid transport
A8142_RS03115	COG0714	Associated with various cellular activities
A8142_RS03120	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A8142_RS03125	COG1305	Transglutaminase-like
A8142_RS03150	COG2252	PERMEase
A8142_RS03155	COG3064	Membrane
A8142_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8142_RS03180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8142_RS03185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8142_RS03190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8142_RS03195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8142_RS03210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A8142_RS03220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8142_RS03225	COG0138	bifunctional purine biosynthesis protein purh
A8142_RS03230	COG0151	Belongs to the GarS family
A8142_RS03240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8142_RS03245	COG1470	cell adhesion involved in biofilm formation
A8142_RS03250	COG4496	protein, YerC YecD
A8142_RS03255	COG0069	glutamate synthase activity
A8142_RS03270	COG0210	DNA helicase
A8142_RS03280	COG4851	CamS sex pheromone cAM373 precursor
A8142_RS03285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8142_RS03290	COG1285	pathogenesis
A8142_RS03295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8142_RS03315	COG1309	transcriptional regulator
A8142_RS03320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8142_RS03325	COG1597	lipid kinase activity
A8142_RS03330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8142_RS03340	COG1131	(ABC) transporter
A8142_RS03380	COG5444	nuclease activity
A8142_RS03410	COG3546	catalase activity
A8142_RS03415	COG0454	-acetyltransferase
A8142_RS03425	COG2323	membrane
A8142_RS03430	COG2329	Antibiotic biosynthesis monooxygenase
A8142_RS03435	COG0346	lactoylglutathione lyase activity
A8142_RS03440	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS03445	COG5583	Uncharacterized small protein (DUF2292)
A8142_RS03450	COG0196	riboflavin kinase activity
A8142_RS03455	COG0670	Belongs to the BI1 family
A8142_RS03460	COG1846	Transcriptional regulator
A8142_RS03465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8142_RS03475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8142_RS03475	COG2124	cytochrome p450
A8142_RS03480	COG1368	sulfuric ester hydrolase activity
A8142_RS03485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8142_RS03490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS03495	COG1442	glycosyl transferase family 8
A8142_RS03500	COG1216	Glycosyl transferase, family 2
A8142_RS03505	COG1442	glycosyl transferase family 8
A8142_RS03510	COG2223	nitrite transmembrane transporter activity
A8142_RS03515	COG0531	amino acid
A8142_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS03525	COG0840	transmembrane signaling receptor activity
A8142_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS03535	COG0457	Tetratricopeptide repeat
A8142_RS03535	COG0463	Glycosyl transferase, family 2
A8142_RS03540	COG0488	(ABC) transporter
A8142_RS03545	COG0789	Transcriptional regulator
A8142_RS03550	COG2814	Major facilitator Superfamily
A8142_RS03555	COG0488	(ABC) transporter
A8142_RS03560	COG0513	Belongs to the DEAD box helicase family
A8142_RS03565	COG0456	acetyltransferase
A8142_RS03570	COG2130	NADP-dependent
A8142_RS03585	COG3866	Pectate lyase
A8142_RS03590	COG0471	metal ion transport
A8142_RS03610	COG3290	protein histidine kinase activity
A8142_RS03615	COG4565	transcriptional regulatory protein
A8142_RS03620	COG3181	Tripartite tricarboxylate transporter family receptor
A8142_RS03625	COG2851	Citrate transporter
A8142_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS03635	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A8142_RS03645	COG2258	MOSC domain
A8142_RS03660	COG0024	Methionine aminopeptidase
A8142_RS03665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS03665	COG1263	PTS System
A8142_RS03675	COG1368	sulfuric ester hydrolase activity
A8142_RS03685	COG0071	Belongs to the small heat shock protein (HSP20) family
A8142_RS03700	COG1263	PTS System
A8142_RS03700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS03705	COG0366	Alpha amylase catalytic
A8142_RS03710	COG2188	Transcriptional regulator
A8142_RS03715	COG0778	Nitroreductase
A8142_RS03730	COG0737	Belongs to the 5'-nucleotidase family
A8142_RS03735	COG0693	protein deglycase activity
A8142_RS03740	COG1609	Transcriptional regulator
A8142_RS03755	COG2814	Major facilitator Superfamily
A8142_RS03765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8142_RS03770	COG4980	gas vesicle protein
A8142_RS03775	COG1295	ribonuclease BN
A8142_RS03780	COG0477	Major facilitator Superfamily
A8142_RS03785	COG0387	Pfam Sodium calcium exchanger
A8142_RS03795	COG0668	transmembrane transport
A8142_RS03800	COG0535	radical SAM domain protein
A8142_RS03810	COG0726	polysaccharide deacetylase
A8142_RS03830	COG0745	RESPONSE REGULATOR receiver
A8142_RS03835	COG2205	protein histidine kinase activity
A8142_RS03840	COG2084	Dehydrogenase
A8142_RS03850	COG0598	Magnesium transport protein CorA
A8142_RS03855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8142_RS03860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8142_RS03870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8142_RS03875	COG4637	Psort location Cytoplasmic, score
A8142_RS03880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8142_RS03885	COG0022	dehydrogenase e1 component
A8142_RS03890	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8142_RS03895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8142_RS03900	COG3284	Transcriptional regulator
A8142_RS03910	COG1486	melibiose metabolic process
A8142_RS03915	COG1737	Transcriptional regulator
A8142_RS03920	COG1263	PTS System
A8142_RS03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS03930	COG1132	(ABC) transporter
A8142_RS03935	COG1132	(ABC) transporter
A8142_RS03940	COG2259	Doxx family
A8142_RS03945	COG2514	catechol 2,3-dioxygenase activity
A8142_RS03955	COG1695	Transcriptional regulator
A8142_RS03960	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8142_RS03965	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A8142_RS03970	COG3848	Pyruvate phosphate dikinase
A8142_RS03970	COG0574	Belongs to the PEP-utilizing enzyme family
A8142_RS03975	COG2732	(Barnase) inhibitor
A8142_RS03980	COG2318	DinB family
A8142_RS03985	COG2814	Major facilitator Superfamily
A8142_RS03990	COG1846	Transcriptional regulator
A8142_RS03995	COG0392	lysyltransferase activity
A8142_RS03995	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8142_RS04000	COG0384	phenazine biosynthesis protein PhzF
A8142_RS04005	COG0778	Nitroreductase
A8142_RS04020	COG1090	epimerase
A8142_RS04035	COG2814	Major facilitator Superfamily
A8142_RS04045	COG3591	Belongs to the peptidase S1B family
A8142_RS04060	COG3103	Sh3 type 3 domain protein
A8142_RS04065	COG5658	integral membrane protein
A8142_RS04070	COG0596	Alpha beta hydrolase
A8142_RS04075	COG0463	Glycosyl transferase, family 2
A8142_RS04080	COG4485	Bacterial membrane protein, YfhO
A8142_RS04085	COG1988	membrane-bound metal-dependent
A8142_RS04090	COG1194	a g-specific adenine glycosylase
A8142_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS04120	COG1132	(ABC) transporter
A8142_RS04125	COG4129	membrane
A8142_RS04135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8142_RS04140	COG0735	belongs to the Fur family
A8142_RS04255	COG3340	Belongs to the peptidase S51 family
A8142_RS04265	COG0277	FAD linked oxidase domain protein
A8142_RS04275	COG0747	negative chemotaxis
A8142_RS04280	COG0601	transmembrane transport
A8142_RS04285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8142_RS04290	COG0444	Belongs to the ABC transporter superfamily
A8142_RS04295	COG4608	Belongs to the ABC transporter superfamily
A8142_RS04300	COG0753	catalase activity
A8142_RS04310	COG1116	anion transmembrane transporter activity
A8142_RS04315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8142_RS04320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8142_RS04340	COG1476	TRANSCRIPTIONal
A8142_RS04350	COG3382	B3 4 domain protein
A8142_RS04355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8142_RS04365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8142_RS04370	COG0789	Transcriptional regulator
A8142_RS04375	COG1664	Polymer-forming cytoskeletal
A8142_RS04380	COG1664	Polymer-forming cytoskeletal
A8142_RS04385	COG2766	serine protein kinase
A8142_RS04395	COG1846	Transcriptional regulator
A8142_RS04400	COG1566	PFAM secretion protein HlyD family protein
A8142_RS04405	COG2814	Major facilitator Superfamily
A8142_RS04410	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8142_RS04420	COG1131	(ABC) transporter
A8142_RS04425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8142_RS04430	COG1278	Cold shock
A8142_RS04435	COG1464	Belongs to the NlpA lipoprotein family
A8142_RS04440	COG3706	GGDEF domain
A8142_RS04445	COG1823	symporter activity
A8142_RS04465	COG5577	PFAM Coat F domain
A8142_RS04470	COG0737	Belongs to the 5'-nucleotidase family
A8142_RS04470	COG1525	nuclease
A8142_RS04470	COG4085	toxin activity
A8142_RS04475	COG3764	Sortase (surface protein transpeptidase)
A8142_RS04480	COG0564	pseudouridine synthase activity
A8142_RS04490	COG0517	IMP dehydrogenase activity
A8142_RS04495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8142_RS04500	COG3153	acetyltransferase
A8142_RS04500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8142_RS04505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8142_RS04510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A8142_RS04515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8142_RS04525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8142_RS04530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8142_RS04535	COG4585	Histidine kinase
A8142_RS04535	COG2203	Gaf domain
A8142_RS04540	COG2197	response regulator
A8142_RS04545	COG0431	NADPH-dependent FMN reductase
A8142_RS04560	COG1388	LysM domain
A8142_RS04560	COG0791	NLP P60 protein
A8142_RS04565	COG1959	2 iron, 2 sulfur cluster binding
A8142_RS04570	COG0668	transmembrane transport
A8142_RS04575	COG2719	SpoVR family
A8142_RS04580	COG1785	Belongs to the alkaline phosphatase family
A8142_RS04585	COG0791	NLP P60 protein
A8142_RS04585	COG1388	LysM domain
A8142_RS04590	COG0583	DNA-binding transcription factor activity
A8142_RS04595	COG0372	Belongs to the citrate synthase family
A8142_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS04605	COG0531	amino acid
A8142_RS04610	COG0733	neurotransmitter:sodium symporter activity
A8142_RS04625	COG1595	DNA-templated transcription, initiation
A8142_RS04630	COG0204	Acyl-transferase
A8142_RS04635	COG1253	flavin adenine dinucleotide binding
A8142_RS04640	COG0789	Transcriptional regulator
A8142_RS04645	COG0436	Aminotransferase
A8142_RS04650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8142_RS04655	COG1253	flavin adenine dinucleotide binding
A8142_RS04660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8142_RS04665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8142_RS04670	COG0584	glycerophosphoryl diester phosphodiesterase
A8142_RS04675	COG0668	transmembrane transport
A8142_RS04680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8142_RS04685	COG0726	polysaccharide deacetylase
A8142_RS04690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8142_RS04695	COG3226	Transcriptional regulator
A8142_RS04705	COG0589	response to stress
A8142_RS04710	COG1132	(ABC) transporter
A8142_RS04715	COG1132	(ABC) transporter
A8142_RS04720	COG0702	epimerase
A8142_RS04735	COG0189	ligase activity
A8142_RS04740	COG0189	ligase activity
A8142_RS04755	COG4335	DNA alkylation repair
A8142_RS04760	COG0561	phosphatase activity
A8142_RS04765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8142_RS04775	COG0475	glutathione-regulated potassium exporter activity
A8142_RS04780	COG0490	domain, Protein
A8142_RS04790	COG1024	Enoyl-CoA hydratase
A8142_RS04800	COG4152	abc transporter atp-binding protein
A8142_RS04805	COG1668	transmembrane transport
A8142_RS04810	COG0420	3'-5' exonuclease activity
A8142_RS04815	COG4717	serine-type aminopeptidase activity
A8142_RS04830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8142_RS04860	COG4980	gas vesicle protein
A8142_RS04875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8142_RS04880	COG0537	adenosine 5'-monophosphoramidase activity
A8142_RS04885	COG1131	(ABC) transporter
A8142_RS04890	COG4473	ABC transporter
A8142_RS04900	COG1473	amidohydrolase
A8142_RS04905	COG3069	C4-dicarboxylate transmembrane transporter activity
A8142_RS04910	COG2329	Antibiotic biosynthesis monooxygenase
A8142_RS04915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8142_RS04925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8142_RS04930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A8142_RS04935	COG1309	transcriptional regulator
A8142_RS04940	COG1511	domain protein
A8142_RS04945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8142_RS04955	COG1363	Peptidase, m42
A8142_RS04960	COG1301	dicarboxylic acid transport
A8142_RS04970	COG1234	tRNA 3'-trailer cleavage
A8142_RS04975	COG0095	Lipoate-protein ligase
A8142_RS04980	COG0702	epimerase
A8142_RS04985	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS04995	COG0501	Belongs to the peptidase M48B family
A8142_RS05000	COG1404	Belongs to the peptidase S8 family
A8142_RS05010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8142_RS05015	COG0406	alpha-ribazole phosphatase activity
A8142_RS05020	COG0183	Belongs to the thiolase family
A8142_RS05025	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS05030	COG1268	BioY protein
A8142_RS05035	COG0840	transmembrane signaling receptor activity
A8142_RS05040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8142_RS05040	COG0723	plastoquinol--plastocyanin reductase activity
A8142_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS05055	COG4903	ComK protein
A8142_RS05065	COG5646	InterPro IPR014922
A8142_RS05085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8142_RS05100	COG0398	Pfam SNARE associated Golgi protein
A8142_RS05105	COG0681	Belongs to the peptidase S26 family
A8142_RS05110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8142_RS05115	COG1846	Transcriptional regulator
A8142_RS05120	COG3180	Ammonia monooxygenase
A8142_RS05125	COG2814	Major facilitator Superfamily
A8142_RS05135	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A8142_RS05140	COG2323	membrane
A8142_RS05155	COG0420	3'-5' exonuclease activity
A8142_RS05160	COG0419	ATPase involved in DNA repair
A8142_RS05165	COG1403	HNH endonuclease
A8142_RS05205	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8142_RS05220	COG0367	asparagine synthase
A8142_RS05225	COG1562	ergosterol biosynthetic process
A8142_RS05230	COG0534	Mate efflux family protein
A8142_RS05235	COG1917	Cupin 2, conserved barrel domain protein
A8142_RS05235	COG2207	Transcriptional regulator
A8142_RS05240	COG0673	inositol 2-dehydrogenase activity
A8142_RS05245	COG2318	DinB family
A8142_RS05250	COG1279	arginine transmembrane transporter activity
A8142_RS05255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS05260	COG1357	PFAM Pentapeptide repeats (8 copies)
A8142_RS05265	COG2153	protein acetylation
A8142_RS05270	COG0646	methionine synthase
A8142_RS05270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8142_RS05280	COG2996	Protein conserved in bacteria
A8142_RS05285	COG1744	ABC transporter substrate-binding protein PnrA-like
A8142_RS05290	COG0840	transmembrane signaling receptor activity
A8142_RS05295	COG2124	cytochrome p450
A8142_RS05300	COG1307	EDD domain protein, DegV family
A8142_RS05305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS05320	COG0561	phosphatase activity
A8142_RS05325	COG1073	alpha beta
A8142_RS05330	COG2151	metal-sulfur cluster biosynthetic enzyme
A8142_RS05340	COG0277	FAD linked oxidase domain protein
A8142_RS05345	COG2271	Major facilitator Superfamily
A8142_RS05355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8142_RS05365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8142_RS05370	COG0505	Belongs to the CarA family
A8142_RS05375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8142_RS05380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8142_RS05395	COG2267	carboxylic ester hydrolase activity
A8142_RS05405	COG1744	ABC transporter substrate-binding protein PnrA-like
A8142_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8142_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8142_RS05430	COG5504	Zn-dependent protease
A8142_RS05435	COG0444	Belongs to the ABC transporter superfamily
A8142_RS05440	COG4608	Belongs to the ABC transporter superfamily
A8142_RS05450	COG0601	transmembrane transport
A8142_RS05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8142_RS05465	COG0180	Tryptophanyl-tRNA synthetase
A8142_RS05470	COG4166	transmembrane transport
A8142_RS05475	COG0601	transmembrane transport
A8142_RS05480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8142_RS05485	COG0444	Belongs to the ABC transporter superfamily
A8142_RS05490	COG4608	Belongs to the ABC transporter superfamily
A8142_RS05500	COG0456	acetyltransferase
A8142_RS05505	COG1393	Belongs to the ArsC family
A8142_RS05510	COG0861	Integral membrane protein TerC family
A8142_RS05515	COG4862	establishment of competence for transformation
A8142_RS05520	COG4469	Competence protein
A8142_RS05525	COG1164	Oligoendopeptidase f
A8142_RS05530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8142_RS05535	COG2346	COG2346, Truncated hemoglobins
A8142_RS05540	COG0741	lytic transglycosylase activity
A8142_RS05545	COG4116	CYTH
A8142_RS05555	COG2357	RelA SpoT domain protein
A8142_RS05560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8142_RS05565	COG0564	pseudouridine synthase activity
A8142_RS05575	COG0569	domain protein
A8142_RS05575	COG0475	glutathione-regulated potassium exporter activity
A8142_RS05580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8142_RS05585	COG0352	thiamine-phosphate diphosphorylase activity
A8142_RS05590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8142_RS05595	COG2104	thiamine diphosphate biosynthetic process
A8142_RS05605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8142_RS05610	COG0351	phosphomethylpyrimidine kinase
A8142_RS05615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8142_RS05670	COG0210	DNA helicase
A8142_RS05690	COG1131	(ABC) transporter
A8142_RS05700	COG2153	protein acetylation
A8142_RS05710	COG2382	esterase
A8142_RS05715	COG0626	cystathionine gamma-synthase activity
A8142_RS05720	COG0626	cystathionine gamma-synthase activity
A8142_RS05750	COG5444	nuclease activity
A8142_RS05760	COG0346	lactoylglutathione lyase activity
A8142_RS05765	COG2367	Beta-lactamase
A8142_RS05770	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A8142_RS05775	COG0477	Major facilitator Superfamily
A8142_RS05780	COG1846	Transcriptional regulator
A8142_RS05790	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A8142_RS05795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8142_RS05800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8142_RS05805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS05805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS05810	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8142_RS05820	COG1349	DNA-binding transcription factor activity
A8142_RS05840	COG1285	pathogenesis
A8142_RS05855	COG2205	protein histidine kinase activity
A8142_RS05865	COG3383	formate dehydrogenase (NAD+) activity
A8142_RS05870	COG2427	Protein of unknown function (DUF1641)
A8142_RS05875	COG2124	cytochrome p450
A8142_RS05880	COG1819	glycosyl
A8142_RS05890	COG1587	Uroporphyrinogen-III synthase
A8142_RS05895	COG0390	transport system, permease component
A8142_RS05900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8142_RS05905	COG0697	spore germination
A8142_RS05910	COG4297	protein containing double-stranded beta helix domain
A8142_RS05920	COG1252	NADH dehydrogenase
A8142_RS05930	COG2211	Major facilitator Superfamily
A8142_RS05935	COG1609	Transcriptional regulator
A8142_RS05940	COG0246	Mannitol dehydrogenase
A8142_RS05945	COG2721	sulfolactate sulfo-lyase activity
A8142_RS05950	COG0745	RESPONSE REGULATOR receiver
A8142_RS05955	COG2770	Histidine kinase
A8142_RS05955	COG2205	protein histidine kinase activity
A8142_RS05975	COG4585	Histidine kinase
A8142_RS05980	COG2197	response regulator
A8142_RS06005	COG0730	response to heat
A8142_RS06010	COG2318	DinB family
A8142_RS06015	COG0457	Tetratricopeptide repeat
A8142_RS06020	COG1388	LysM domain
A8142_RS06020	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS06020	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8142_RS06030	COG4195	phage-related replication protein
A8142_RS06035	COG2856	Zn peptidase
A8142_RS06040	COG1396	sequence-specific DNA binding
A8142_RS06050	COG1522	sequence-specific DNA binding
A8142_RS06055	COG1484	DNA-dependent DNA replication
A8142_RS06070	COG1595	DNA-templated transcription, initiation
A8142_RS06075	COG5484	DNA packaging
A8142_RS06075	COG3728	DNA packaging
A8142_RS06080	COG1783	phage Terminase large subunit
A8142_RS06085	COG5518	Phage portal protein
A8142_RS06090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A8142_RS06095	COG4653	Phage capsid family
A8142_RS06140	COG5412	phage tail tape measure protein
A8142_RS06140	COG3953	SLT domain
A8142_RS06140	COG5412	phage tail tape measure protein
A8142_RS06140	COG3953	SLT domain
A8142_RS06140	COG3953	SLT domain
A8142_RS06140	COG5412	phage tail tape measure protein
A8142_RS06145	COG1652	LysM domain
A8142_RS06150	COG4193	domain, Protein
A8142_RS06160	COG3628	GPW Gp25 family protein
A8142_RS06165	COG3299	homolog of phage Mu protein gp47
A8142_RS06170	COG3778	Protein conserved in bacteria
A8142_RS06210	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS06210	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8142_RS06225	COG0306	phosphate transporter
A8142_RS06230	COG1392	Phosphate transport regulator
A8142_RS06235	COG0531	amino acid
A8142_RS06240	COG0346	lactoylglutathione lyase activity
A8142_RS06245	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8142_RS06250	COG0463	Glycosyl transferase, family 2
A8142_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8142_RS06260	COG0477	Major facilitator Superfamily
A8142_RS06265	COG2362	D-Aminopeptidase
A8142_RS06270	COG0601	transmembrane transport
A8142_RS06275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8142_RS06280	COG0444	Belongs to the ABC transporter superfamily
A8142_RS06285	COG4166	transmembrane transport
A8142_RS06290	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8142_RS06295	COG4948	Mandelate Racemase Muconate Lactonizing
A8142_RS06300	COG0791	NLP P60 protein
A8142_RS06305	COG4608	Belongs to the ABC transporter superfamily
A8142_RS06310	COG2706	6-phosphogluconolactonase activity
A8142_RS06315	COG1834	amidinotransferase
A8142_RS06320	COG1607	acyl-coa hydrolase
A8142_RS06325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8142_RS06330	COG2076	Multidrug Resistance protein
A8142_RS06335	COG2076	Multidrug Resistance protein
A8142_RS06340	COG0788	formyltetrahydrofolate deformylase activity
A8142_RS06345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8142_RS06355	COG1764	response to oxidative stress
A8142_RS06360	COG1846	Transcriptional regulator
A8142_RS06365	COG1764	response to oxidative stress
A8142_RS06380	COG0463	Glycosyl transferase, family 2
A8142_RS06380	COG0457	Tetratricopeptide repeat
A8142_RS06400	COG1404	Belongs to the peptidase S8 family
A8142_RS06405	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS06410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8142_RS06415	COG1122	ATPase activity
A8142_RS06420	COG4721	ABC-type cobalt transport system, permease component
A8142_RS06425	COG3858	chitin binding
A8142_RS06425	COG1388	LysM domain
A8142_RS06430	COG2239	Acts as a magnesium transporter
A8142_RS06435	COG0789	Transcriptional regulator
A8142_RS06445	COG1846	Transcriptional regulator
A8142_RS06450	COG0726	polysaccharide deacetylase
A8142_RS06455	COG3285	dna ligase
A8142_RS06455	COG1793	dna ligase
A8142_RS06460	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A8142_RS06470	COG0586	Pfam SNARE associated Golgi protein
A8142_RS06475	COG0861	Integral membrane protein TerC family
A8142_RS06480	COG1191	sigma factor activity
A8142_RS06505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8142_RS06510	COG2323	membrane
A8142_RS06515	COG3594	Acyltransferase
A8142_RS06520	COG5002	protein histidine kinase activity
A8142_RS06525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8142_RS06540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8142_RS06545	COG0436	Aminotransferase
A8142_RS06575	COG3852	Histidine kinase
A8142_RS06580	COG1846	Transcriptional regulator
A8142_RS06585	COG1360	Flagellar Motor Protein
A8142_RS06590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8142_RS06595	COG0542	response to heat
A8142_RS06600	COG3949	Membrane
A8142_RS06615	COG0720	synthase
A8142_RS06620	COG0602	queuosine metabolic process
A8142_RS06635	COG1733	regulation of RNA biosynthetic process
A8142_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS06655	COG4873	Protein conserved in bacteria
A8142_RS06665	COG3773	Cell wall hydrolase
A8142_RS06670	COG2244	polysaccharide biosynthetic process
A8142_RS06675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS06680	COG2217	Heavy metal translocating P-type atpase
A8142_RS06685	COG0006	proline dipeptidase activity
A8142_RS06690	COG1609	Transcriptional regulator
A8142_RS06695	COG3711	transcriptional antiterminator
A8142_RS06700	COG1263	PTS System
A8142_RS06700	COG2190	(PTS) system
A8142_RS06700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS06705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS06710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8142_RS06720	COG1533	DNA photolyase activity
A8142_RS06725	COG0840	transmembrane signaling receptor activity
A8142_RS06730	COG2084	Dehydrogenase
A8142_RS06735	COG2340	Cysteine-rich secretory protein family
A8142_RS06740	COG0768	penicillin binding
A8142_RS06745	COG4191	Histidine kinase
A8142_RS06750	COG0436	Aminotransferase
A8142_RS06755	COG0784	Response regulator, receiver
A8142_RS06755	COG0835	chemotaxis
A8142_RS06765	COG2814	Major facilitator Superfamily
A8142_RS06770	COG1376	ErfK ybiS ycfS ynhG family protein
A8142_RS06775	COG1408	metallophosphoesterase
A8142_RS06780	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS06790	COG2200	EAL domain
A8142_RS06795	COG4703	Protein of unknown function (DUF1797)
A8142_RS06800	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A8142_RS06810	COG0517	IMP dehydrogenase activity
A8142_RS06815	COG0583	DNA-binding transcription factor activity
A8142_RS06820	COG0716	FMN binding
A8142_RS06830	COG0716	FMN binding
A8142_RS06850	COG0668	transmembrane transport
A8142_RS06855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS06875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8142_RS06880	COG0303	'Molybdopterin
A8142_RS06885	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8142_RS06890	COG0314	molybdopterin synthase activity
A8142_RS06895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A8142_RS06905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8142_RS06910	COG1136	(ABC) transporter
A8142_RS06915	COG0577	efflux transmembrane transporter activity
A8142_RS06920	COG1349	DNA-binding transcription factor activity
A8142_RS06925	COG1105	Belongs to the carbohydrate kinase PfkB family
A8142_RS06930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS06930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8142_RS06930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8142_RS06935	COG0681	Belongs to the peptidase S26 family
A8142_RS06945	COG0488	(ABC) transporter
A8142_RS06950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8142_RS06955	COG2309	aminopeptidase activity
A8142_RS06960	COG1077	Cell shape determining protein MreB Mrl
A8142_RS06965	COG2002	toxin-antitoxin pair type II binding
A8142_RS06970	COG3852	Histidine kinase
A8142_RS06975	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A8142_RS06975	COG2105	PFAM AIG2 family protein
A8142_RS06980	COG0569	domain protein
A8142_RS06990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8142_RS07000	COG0561	phosphatase activity
A8142_RS07005	COG0242	peptide deformylase activity
A8142_RS07015	COG0497	DNA recombination
A8142_RS07020	COG2070	2-Nitropropane dioxygenase
A8142_RS07020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8142_RS07025	COG4221	oxidoreductase activity
A8142_RS07025	COG3321	synthase
A8142_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS07025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS07030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS07030	COG0300	oxidoreductase activity
A8142_RS07030	COG3321	synthase
A8142_RS07030	COG4221	oxidoreductase activity
A8142_RS07035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS07035	COG3321	synthase
A8142_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS07035	COG4221	oxidoreductase activity
A8142_RS07040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS07040	COG0300	oxidoreductase activity
A8142_RS07040	COG3321	synthase
A8142_RS07040	COG4221	oxidoreductase activity
A8142_RS07045	COG4221	oxidoreductase activity
A8142_RS07045	COG3321	synthase
A8142_RS07045	COG0300	oxidoreductase activity
A8142_RS07045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS07050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS07050	COG4221	oxidoreductase activity
A8142_RS07050	COG3321	synthase
A8142_RS07050	COG0300	oxidoreductase activity
A8142_RS07055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS07055	COG4221	oxidoreductase activity
A8142_RS07055	COG3321	synthase
A8142_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS07060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8142_RS07065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8142_RS07070	COG0022	dehydrogenase e1 component
A8142_RS07075	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8142_RS07080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8142_RS07085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS07095	COG1982	Orn Lys Arg decarboxylase major
A8142_RS07115	COG0483	inositol monophosphate 1-phosphatase activity
A8142_RS07125	COG3227	Zinc metalloprotease (Elastase)
A8142_RS07145	COG1217	gtp-binding protein TYPA
A8142_RS07155	COG4896	Protein conserved in bacteria
A8142_RS07165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8142_RS07170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8142_RS07175	COG2066	Belongs to the glutaminase family
A8142_RS07185	COG0772	Belongs to the SEDS family
A8142_RS07190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8142_RS07205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8142_RS07205	COG2010	Cytochrome c
A8142_RS07210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8142_RS07215	COG1845	cytochrome c oxidase, subunit III
A8142_RS07220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8142_RS07225	COG3336	cytochrome c oxidase
A8142_RS07235	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A8142_RS07240	COG2340	Cysteine-rich secretory protein family
A8142_RS07255	COG3679	Belongs to the UPF0342 family
A8142_RS07265	COG0742	ribosomal rna small subunit methyltransferase
A8142_RS07275	COG3314	Sporulation integral membrane protein YlbJ
A8142_RS07280	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8142_RS07285	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8142_RS07295	COG1399	metal-binding, possibly nucleic acid-binding protein
A8142_RS07310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8142_RS07330	COG4839	cell division protein FtsL
A8142_RS07335	COG0768	penicillin binding
A8142_RS07340	COG0768	penicillin binding
A8142_RS07360	COG0772	Belongs to the SEDS family
A8142_RS07375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8142_RS07380	COG0849	cell division
A8142_RS07385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8142_RS07390	COG1404	Belongs to the peptidase S8 family
A8142_RS07390	COG4412	M6 family metalloprotease domain protein
A8142_RS07400	COG1191	sigma factor activity
A8142_RS07405	COG1191	sigma factor activity
A8142_RS07410	COG1119	ATPase activity
A8142_RS07415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8142_RS07420	COG1873	PFAM PRC-barrel domain
A8142_RS07425	COG1496	oxidoreductase activity
A8142_RS07430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8142_RS07440	COG0762	integral membrane protein
A8142_RS07445	COG2302	S4 RNA-binding domain
A8142_RS07450	COG3599	regulation of cell shape
A8142_RS07460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8142_RS07465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8142_RS07475	COG0564	pseudouridine synthase activity
A8142_RS07485	COG2233	PERMEase
A8142_RS07495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8142_RS07500	COG0505	Belongs to the CarA family
A8142_RS07505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8142_RS07520	COG0284	orotidine-5'-phosphate decarboxylase activity
A8142_RS07525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8142_RS07535	COG0306	phosphate transporter
A8142_RS07550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8142_RS07555	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
A8142_RS07560	COG1648	precorrin-2 dehydrogenase activity
A8142_RS07575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8142_RS07580	COG1561	YicC-like family, N-terminal region
A8142_RS07590	COG0194	GDP metabolic process
A8142_RS07600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8142_RS07605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8142_RS07610	COG0242	peptide deformylase activity
A8142_RS07620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8142_RS07620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8142_RS07630	COG0631	protein serine/threonine phosphatase activity
A8142_RS07635	COG0515	serine threonine protein kinase
A8142_RS07635	COG2815	serine threonine protein kinase
A8142_RS07645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8142_RS07650	COG1564	THIamine pyrophosphokinase
A8142_RS07665	COG1302	Protein conserved in bacteria
A8142_RS07670	COG1461	Dihydroxyacetone kinase
A8142_RS07675	COG1760	l-serine dehydratase
A8142_RS07680	COG1760	l-serine dehydratase
A8142_RS07685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8142_RS07700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8142_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS07720	COG1196	nuclear chromosome segregation
A8142_RS07725	COG0552	protein localization to endoplasmic reticulum
A8142_RS07740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8142_RS07750	COG1837	Belongs to the UPF0109 family
A8142_RS07775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8142_RS07790	COG2257	FlhB HrpN YscU SpaS Family
A8142_RS07800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8142_RS07805	COG0758	DNA mediated transformation
A8142_RS07810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8142_RS07820	COG4974	Belongs to the 'phage' integrase family
A8142_RS07840	COG1815	bacterial-type flagellum-dependent cell motility
A8142_RS07845	COG1558	bacterial-type flagellum-dependent cell motility
A8142_RS07850	COG1677	Flagellar hook-basal body complex protein FliE
A8142_RS07855	COG1766	The M ring may be actively involved in energy transduction
A8142_RS07860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8142_RS07865	COG1317	bacterial-type flagellum organization
A8142_RS07870	COG1157	protein secretion by the type III secretion system
A8142_RS07875	COG2882	bacterial-type flagellum organization
A8142_RS07880	COG3334	PFAM MgtE intracellular
A8142_RS07885	COG3144	bacterial-type flagellum assembly
A8142_RS07890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A8142_RS07895	COG4786	Flagellar basal body rod
A8142_RS07900	COG1582	Flagellar protein (FlbD)
A8142_RS07905	COG1580	Controls the rotational direction of flagella during chemotaxis
A8142_RS07910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8142_RS07915	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8142_RS07915	COG1776	CheC inhibitor of MCP methylation
A8142_RS07920	COG2201	protein-glutamate methylesterase activity
A8142_RS07925	COG3190	flagellar
A8142_RS07930	COG1338	Plays a role in the flagellum-specific transport system
A8142_RS07935	COG1987	bacterial-type flagellum assembly
A8142_RS07940	COG1684	flagellar biosynthetic protein fliR
A8142_RS07945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8142_RS07950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8142_RS07955	COG1419	protein localization to endoplasmic reticulum
A8142_RS07960	COG0455	bacterial-type flagellum organization
A8142_RS07965	COG2201	protein-glutamate methylesterase activity
A8142_RS07970	COG0643	Histidine kinase
A8142_RS07970	COG2198	Histidine kinase
A8142_RS07975	COG0835	chemotaxis
A8142_RS07980	COG1776	CheC inhibitor of MCP methylation
A8142_RS07990	COG1191	sigma factor activity
A8142_RS08020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8142_RS08025	COG4589	Belongs to the CDS family
A8142_RS08035	COG0750	zinc metalloprotease
A8142_RS08045	COG2176	DNA-directed DNA polymerase activity
A8142_RS08055	COG0195	Participates in both transcription termination and antitermination
A8142_RS08060	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A8142_RS08065	COG1358	cellular component organization or biogenesis
A8142_RS08075	COG1550	Protein conserved in bacteria
A8142_RS08090	COG0196	riboflavin kinase activity
A8142_RS08105	COG0726	polysaccharide deacetylase
A8142_RS08110	COG0612	Peptidase, M16
A8142_RS08115	COG1873	PFAM PRC-barrel domain
A8142_RS08120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8142_RS08125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8142_RS08130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8142_RS08135	COG0527	aspartate kinase activity
A8142_RS08145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8142_RS08150	COG0740	serine-type endopeptidase activity
A8142_RS08160	COG1674	ftsk spoiiie
A8142_RS08160	COG4980	gas vesicle protein
A8142_RS08165	COG2188	Transcriptional regulator
A8142_RS08170	COG2814	Major facilitator Superfamily
A8142_RS08175	COG1846	Transcriptional regulator
A8142_RS08180	COG1033	growth of symbiont in host cell
A8142_RS08180	COG2409	Drug exporters of the RND superfamily
A8142_RS08185	COG0612	Peptidase, M16
A8142_RS08190	COG0612	Peptidase, M16
A8142_RS08195	COG0300	oxidoreductase activity
A8142_RS08210	COG1426	Protein conserved in bacteria
A8142_RS08215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8142_RS08230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8142_RS08240	COG1692	metallophosphoesterase
A8142_RS08245	COG2359	stage V sporulation protein S
A8142_RS08265	COG4550	Control of competence regulator ComK, YlbF/YmcA
A8142_RS08310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS08315	COG3425	synthase
A8142_RS08320	COG1024	Enoyl-CoA hydratase
A8142_RS08325	COG1024	Enoyl-CoA hydratase
A8142_RS08330	COG3321	synthase
A8142_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS08330	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS08330	COG0300	oxidoreductase activity
A8142_RS08335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS08335	COG0300	oxidoreductase activity
A8142_RS08335	COG3321	synthase
A8142_RS08335	COG4221	oxidoreductase activity
A8142_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS08340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS08340	COG3321	synthase
A8142_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS08340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS08340	COG3321	synthase
A8142_RS08340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS08345	COG3321	synthase
A8142_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08345	COG4221	oxidoreductase activity
A8142_RS08345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS08350	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8142_RS08350	COG3321	synthase
A8142_RS08350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS08350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8142_RS08355	COG2124	cytochrome p450
A8142_RS08360	COG3209	COG3209 Rhs family protein
A8142_RS08365	COG3619	membrane
A8142_RS08375	COG1404	Belongs to the peptidase S8 family
A8142_RS08385	COG4195	phage-related replication protein
A8142_RS08390	COG1764	response to oxidative stress
A8142_RS08400	COG2076	Multidrug Resistance protein
A8142_RS08440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8142_RS08445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8142_RS08450	COG4112	unkown
A8142_RS08455	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS08465	COG0464	growth
A8142_RS08470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8142_RS08475	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A8142_RS08480	COG0789	Transcriptional regulator
A8142_RS08485	COG0174	glutamine synthetase
A8142_RS08525	COG2211	Major facilitator Superfamily
A8142_RS08530	COG3507	Belongs to the glycosyl hydrolase 43 family
A8142_RS08545	COG1070	Carbohydrate kinase
A8142_RS08550	COG3848	Pyruvate phosphate dikinase
A8142_RS08550	COG0574	Belongs to the PEP-utilizing enzyme family
A8142_RS08570	COG2318	DinB family
A8142_RS08575	COG1064	alcohol dehydrogenase
A8142_RS08580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8142_RS08580	COG4451	ribulose bisphosphate carboxylase, small
A8142_RS08620	COG3397	chitin binding
A8142_RS08630	COG5434	Belongs to the glycosyl hydrolase 28 family
A8142_RS08635	COG0756	dUTP diphosphatase activity
A8142_RS08640	COG4195	phage-related replication protein
A8142_RS08670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8142_RS08680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8142_RS08700	COG0785	Cytochrome C biogenesis protein
A8142_RS08705	COG2201	protein-glutamate methylesterase activity
A8142_RS08710	COG4846	Membrane protein involved in cytochrome C biogenesis
A8142_RS08720	COG0071	Belongs to the small heat shock protein (HSP20) family
A8142_RS08735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8142_RS08740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS08760	COG0824	Thioesterase
A8142_RS08770	COG4841	protein insertion into membrane
A8142_RS08780	COG1832	CoA-binding protein
A8142_RS08785	COG0187	DNA topoisomerase II activity
A8142_RS08790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8142_RS08800	COG1115	amino acid carrier protein
A8142_RS08810	COG1063	alcohol dehydrogenase
A8142_RS08815	COG0800	Aldolase
A8142_RS08820	COG1312	Catalyzes the dehydration of D-mannonate
A8142_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08830	COG1609	Transcriptional regulator
A8142_RS08835	COG2271	Major facilitator Superfamily
A8142_RS08885	COG2205	protein histidine kinase activity
A8142_RS08890	COG0745	RESPONSE REGULATOR receiver
A8142_RS08900	COG3507	Belongs to the glycosyl hydrolase 43 family
A8142_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS08930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8142_RS08935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8142_RS08940	COG2610	gluconate transmembrane transporter activity
A8142_RS08945	COG2124	cytochrome p450
A8142_RS08965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8142_RS08975	COG2246	polysaccharide biosynthetic process
A8142_RS08985	COG0586	Pfam SNARE associated Golgi protein
A8142_RS08990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8142_RS08995	COG1024	Enoyl-CoA hydratase
A8142_RS09000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8142_RS09005	COG0511	ligase activity, forming carbon-carbon bonds
A8142_RS09010	COG0439	Biotin carboxylase
A8142_RS09015	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS09020	COG1960	acyl-CoA dehydrogenase activity
A8142_RS09025	COG1649	PFAM Uncharacterised BCR, COG1649
A8142_RS09035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS09035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A8142_RS09040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS09045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS09050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS09055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS09060	COG2027	D-alanyl-D-alanine carboxypeptidase
A8142_RS09065	COG2017	converts alpha-aldose to the beta-anomer
A8142_RS09070	COG0534	Mate efflux family protein
A8142_RS09085	COG0582	viral genome integration into host DNA
A8142_RS09090	COG0166	Belongs to the GPI family
A8142_RS09095	COG0405	Gamma-glutamyltransferase
A8142_RS09100	COG2814	Major facilitator Superfamily
A8142_RS09105	COG0640	Transcriptional regulator
A8142_RS09110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8142_RS09120	COG0604	alcohol dehydrogenase
A8142_RS09125	COG0493	'glutamate synthase
A8142_RS09130	COG0069	glutamate synthase activity
A8142_RS09130	COG0070	glutamate synthase
A8142_RS09130	COG0067	glutamate synthase
A8142_RS09135	COG0583	DNA-binding transcription factor activity
A8142_RS09140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8142_RS09155	COG0300	oxidoreductase activity
A8142_RS09160	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A8142_RS09170	COG2814	Major facilitator Superfamily
A8142_RS09175	COG1070	Carbohydrate kinase
A8142_RS09180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8142_RS09185	COG0243	molybdopterin cofactor binding
A8142_RS09215	COG5444	nuclease activity
A8142_RS09220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8142_RS09225	COG2207	Transcriptional regulator
A8142_RS09225	COG0662	Cupin 2, conserved barrel domain protein
A8142_RS09230	COG1309	transcriptional regulator
A8142_RS09235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS09245	COG0640	Transcriptional regulator
A8142_RS09250	COG0741	lytic transglycosylase activity
A8142_RS09255	COG2322	membrane
A8142_RS09270	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8142_RS09280	COG1388	LysM domain
A8142_RS09280	COG3584	3D domain protein
A8142_RS09285	COG0514	ATP-dependent DNA helicase (RecQ)
A8142_RS09295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8142_RS09300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8142_RS09315	COG0071	Belongs to the small heat shock protein (HSP20) family
A8142_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS09345	COG1657	PFAM Prenyltransferase squalene oxidase
A8142_RS09350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8142_RS09355	COG0733	neurotransmitter:sodium symporter activity
A8142_RS09360	COG0385	Bile acid
A8142_RS09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS09370	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8142_RS09380	COG4548	von Willebrand factor, type A
A8142_RS09385	COG0714	Associated with various cellular activities
A8142_RS09390	COG2032	superoxide dismutase activity
A8142_RS09395	COG1388	LysM domain
A8142_RS09395	COG0791	NLP P60 protein
A8142_RS09400	COG1819	glycosyl
A8142_RS09405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8142_RS09410	COG0534	Mate efflux family protein
A8142_RS09415	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS09420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8142_RS09425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8142_RS09435	COG2962	Rard protein
A8142_RS09450	COG1942	4-Oxalocrotonate Tautomerase
A8142_RS09460	COG1733	regulation of RNA biosynthetic process
A8142_RS09465	COG0778	Nitroreductase
A8142_RS09470	COG0400	carboxylic ester hydrolase activity
A8142_RS09475	COG0346	lactoylglutathione lyase activity
A8142_RS09485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8142_RS09495	COG2723	6-phospho-beta-galactosidase activity
A8142_RS09500	COG2188	Transcriptional regulator
A8142_RS09505	COG0793	Belongs to the peptidase S41A family
A8142_RS09505	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS09510	COG2226	methyltransferase
A8142_RS09520	COG1876	peptidase activity
A8142_RS09535	COG0671	phosphoesterase, PA-phosphatase related
A8142_RS09565	COG1509	lysine 2,3-aminomutase activity
A8142_RS09570	COG0456	acetyltransferase
A8142_RS09575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8142_RS09580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8142_RS09585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8142_RS09590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8142_RS09595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A8142_RS09605	COG0456	acetyltransferase
A8142_RS09610	COG0463	Glycosyl transferase, family 2
A8142_RS09625	COG4641	Protein conserved in bacteria
A8142_RS09635	COG1086	Polysaccharide biosynthesis protein
A8142_RS09660	COG0457	Tetratricopeptide repeat
A8142_RS09670	COG3391	amine dehydrogenase activity
A8142_RS09690	COG5444	nuclease activity
A8142_RS09695	COG4282	regulation of fungal-type cell wall biogenesis
A8142_RS09700	COG1525	nuclease
A8142_RS09705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8142_RS09725	COG1846	Transcriptional regulator
A8142_RS09730	COG4698	Protein conserved in bacteria
A8142_RS09735	COG2755	lipolytic protein G-D-S-L family
A8142_RS09740	COG1999	signal sequence binding
A8142_RS09750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8142_RS09755	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8142_RS09760	COG1272	protein, Hemolysin III
A8142_RS09765	COG0204	Acyl-transferase
A8142_RS09770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8142_RS09785	COG2136	Putative SAM-dependent methyltransferase
A8142_RS09785	COG2521	methyltransferase
A8142_RS09800	COG1413	lyase activity
A8142_RS09805	COG1418	mRNA catabolic process
A8142_RS09810	COG0386	Belongs to the glutathione peroxidase family
A8142_RS09820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8142_RS09825	COG1278	Cold shock
A8142_RS09845	COG0328	RNA-DNA hybrid ribonuclease activity
A8142_RS09850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8142_RS09855	COG0328	RNA-DNA hybrid ribonuclease activity
A8142_RS09865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8142_RS09875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8142_RS09880	COG1755	Isoprenylcysteine carboxyl methyltransferase
A8142_RS09885	COG3424	synthase
A8142_RS09905	COG1335	isochorismatase
A8142_RS09915	COG2233	PERMEase
A8142_RS09925	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A8142_RS09930	COG1199	ATP-dependent helicase activity
A8142_RS09940	COG0116	Belongs to the methyltransferase superfamily
A8142_RS09960	COG3359	exonuclease
A8142_RS09965	COG1205	dead DEAH box helicase
A8142_RS09965	COG1111	helicase
A8142_RS09970	COG2190	(PTS) system
A8142_RS09975	COG0071	Belongs to the small heat shock protein (HSP20) family
A8142_RS10015	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8142_RS10015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8142_RS10025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8142_RS10030	COG3935	DnaD domain protein
A8142_RS10040	COG0436	Aminotransferase
A8142_RS10045	COG5353	protein conserved in bacteria
A8142_RS10055	COG1199	ATP-dependent helicase activity
A8142_RS10055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8142_RS10085	COG0438	transferase activity, transferring glycosyl groups
A8142_RS10090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8142_RS10105	COG1694	Mazg nucleotide pyrophosphohydrolase
A8142_RS10110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS10125	COG4347	Protein of unknown function (DUF1405)
A8142_RS10130	COG2010	Cytochrome c
A8142_RS10130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8142_RS10135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8142_RS10140	COG0723	plastoquinol--plastocyanin reductase activity
A8142_RS10155	COG0457	Tetratricopeptide repeat
A8142_RS10165	COG0287	Prephenate dehydrogenase
A8142_RS10200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8142_RS10205	COG4401	Chorismate mutase type I
A8142_RS10220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8142_RS10225	COG0105	UTP biosynthetic process
A8142_RS10230	COG0142	geranyltranstransferase activity
A8142_RS10240	COG0142	geranyltranstransferase activity
A8142_RS10255	COG0776	regulation of translation
A8142_RS10260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8142_RS10300	COG0539	negative regulation of cytoplasmic translation
A8142_RS10310	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A8142_RS10315	COG2959	enzyme of heme biosynthesis
A8142_RS10320	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS10320	COG3773	Cell wall hydrolase
A8142_RS10325	COG2339	peptidase activity
A8142_RS10330	COG0492	ferredoxin-NADP+ reductase activity
A8142_RS10335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8142_RS10340	COG4862	establishment of competence for transformation
A8142_RS10345	COG1408	metallophosphoesterase
A8142_RS10355	COG1388	LysM domain
A8142_RS10360	COG1266	CAAX protease self-immunity
A8142_RS10365	COG0514	ATP-dependent DNA helicase (RecQ)
A8142_RS10370	COG4955	Helix-turn-helix domain
A8142_RS10375	COG1141	Ferredoxin
A8142_RS10380	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A8142_RS10385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8142_RS10395	COG1595	DNA-templated transcription, initiation
A8142_RS10400	COG5002	protein histidine kinase activity
A8142_RS10405	COG0745	RESPONSE REGULATOR receiver
A8142_RS10410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8142_RS10415	COG1333	cytochrome c biogenesis protein
A8142_RS10420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS10425	COG1187	pseudouridine synthase activity
A8142_RS10430	COG0700	Nucleoside recognition
A8142_RS10435	COG2715	membrane protein required for spore maturation
A8142_RS10440	COG1686	Belongs to the peptidase S11 family
A8142_RS10460	COG1547	Domain of unknown function (DUF309)
A8142_RS10465	COG0456	acetyltransferase
A8142_RS10480	COG0307	riboflavin synthase, alpha
A8142_RS10485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8142_RS10485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8142_RS10495	COG0681	Belongs to the peptidase S26 family
A8142_RS10505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8142_RS10510	COG4086	secreted protein
A8142_RS10515	COG0019	diaminopimelate decarboxylase activity
A8142_RS10520	COG0697	spore germination
A8142_RS10535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8142_RS10555	COG1191	sigma factor activity
A8142_RS10565	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS10570	COG1686	Belongs to the peptidase S11 family
A8142_RS10575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A8142_RS10580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A8142_RS10585	COG4974	Belongs to the 'phage' integrase family
A8142_RS10595	COG0735	belongs to the Fur family
A8142_RS10600	COG1300	Membrane
A8142_RS10615	COG0281	malic enzyme
A8142_RS10620	COG1757	Na H antiporter
A8142_RS10625	COG1027	Aspartate ammonia-lyase
A8142_RS10630	COG0252	asparaginase activity
A8142_RS10635	COG1396	sequence-specific DNA binding
A8142_RS10640	COG1379	DNA repair
A8142_RS10645	COG0494	nUDIX hydrolase
A8142_RS10655	COG0667	Aldo Keto reductase
A8142_RS10665	COG1073	alpha beta
A8142_RS10675	COG4918	Iron-sulphur cluster biosynthesis
A8142_RS10680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8142_RS10680	COG0456	acetyltransferase
A8142_RS10685	COG2329	Antibiotic biosynthesis monooxygenase
A8142_RS10690	COG0456	acetyltransferase
A8142_RS10695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8142_RS10710	COG0628	permease
A8142_RS10715	COG0346	lactoylglutathione lyase activity
A8142_RS10725	COG3048	D-serine ammonia-lyase activity
A8142_RS10730	COG0300	oxidoreductase activity
A8142_RS10735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS10740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8142_RS10745	COG1024	Enoyl-CoA hydratase
A8142_RS10750	COG3425	synthase
A8142_RS10755	COG2124	cytochrome p450
A8142_RS10760	COG3321	synthase
A8142_RS10760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS10765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS10765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10765	COG3321	synthase
A8142_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10770	COG0300	oxidoreductase activity
A8142_RS10770	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS10770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10770	COG3321	synthase
A8142_RS10775	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS10775	COG3321	synthase
A8142_RS10775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10775	COG0300	oxidoreductase activity
A8142_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10780	COG3321	synthase
A8142_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS10780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS10780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10785	COG3321	synthase
A8142_RS10785	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS10785	COG0300	oxidoreductase activity
A8142_RS10785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS10790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8142_RS10790	COG3321	synthase
A8142_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS10815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8142_RS10815	COG2070	2-Nitropropane dioxygenase
A8142_RS10820	COG0250	Participates in transcription elongation, termination and antitermination
A8142_RS10840	COG0596	Alpha beta hydrolase
A8142_RS10855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8142_RS10860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8142_RS10875	COG0706	membrane insertase activity
A8142_RS10880	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8142_RS10885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8142_RS10890	COG0346	lactoylglutathione lyase activity
A8142_RS10900	COG4129	membrane
A8142_RS10905	COG1126	abc transporter atp-binding protein
A8142_RS10910	COG0765	amino acid transport
A8142_RS10915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8142_RS10925	COG1597	lipid kinase activity
A8142_RS10930	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8142_RS10935	COG0022	dehydrogenase e1 component
A8142_RS10940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8142_RS10945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8142_RS10950	COG3426	butyrate kinase activity
A8142_RS10955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8142_RS10960	COG0280	phosphate acetyltransferase
A8142_RS10965	COG3290	protein histidine kinase activity
A8142_RS10965	COG3829	transcription factor binding
A8142_RS10975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8142_RS10980	COG2079	MmgE PrpD family protein
A8142_RS10985	COG0372	Belongs to the citrate synthase family
A8142_RS10990	COG1960	acyl-CoA dehydrogenase activity
A8142_RS10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8142_RS11000	COG0183	Belongs to the thiolase family
A8142_RS11005	COG0584	glycerophosphoryl diester phosphodiesterase
A8142_RS11010	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS11035	COG1902	pentaerythritol trinitrate reductase activity
A8142_RS11050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8142_RS11055	COG0745	RESPONSE REGULATOR receiver
A8142_RS11060	COG0750	zinc metalloprotease
A8142_RS11065	COG0497	DNA recombination
A8142_RS11075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A8142_RS11085	COG0142	geranyltranstransferase activity
A8142_RS11095	COG1570	exodeoxyribonuclease VII activity
A8142_RS11110	COG1302	Protein conserved in bacteria
A8142_RS11115	COG0439	Biotin carboxylase
A8142_RS11120	COG0511	ligase activity, forming carbon-carbon bonds
A8142_RS11160	COG3854	ATPases associated with a variety of cellular activities
A8142_RS11175	COG0006	proline dipeptidase activity
A8142_RS11185	COG3872	metal-dependent enzyme
A8142_RS11195	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8142_RS11210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8142_RS11230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8142_RS11245	COG1396	sequence-specific DNA binding
A8142_RS11255	COG0681	Belongs to the peptidase S26 family
A8142_RS11280	COG4940	Competence protein ComGF
A8142_RS11290	COG4970	Tfp pilus assembly protein FimT
A8142_RS11295	COG4537	Required for transformation and DNA binding
A8142_RS11300	COG1459	type II secretion system
A8142_RS11305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8142_RS11310	COG0598	Magnesium transport protein CorA
A8142_RS11315	COG1253	flavin adenine dinucleotide binding
A8142_RS11320	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS11330	COG1393	Belongs to the ArsC family
A8142_RS11340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS11350	COG0011	TIGRFAM Protein of
A8142_RS11360	COG2866	Carboxypeptidase
A8142_RS11365	COG1940	carbohydrate kinase activity
A8142_RS11370	COG4483	Protein conserved in bacteria
A8142_RS11375	COG1757	Na H antiporter
A8142_RS11380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8142_RS11390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8142_RS11395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8142_RS11400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8142_RS11405	COG0581	inorganic phosphate transmembrane transporter activity
A8142_RS11410	COG0573	inorganic phosphate transmembrane transporter activity
A8142_RS11415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8142_RS11420	COG0768	penicillin binding
A8142_RS11425	COG0477	Major facilitator Superfamily
A8142_RS11430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8142_RS11435	COG2839	Protein conserved in bacteria
A8142_RS11440	COG5521	maltodextrose utilization protein MalA
A8142_RS11445	COG1388	LysM domain
A8142_RS11455	COG4709	membrane
A8142_RS11460	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
A8142_RS11465	COG0735	belongs to the Fur family
A8142_RS11470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS11485	COG0513	Belongs to the DEAD box helicase family
A8142_RS11500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8142_RS11505	COG2384	SAM-dependent methyltransferase
A8142_RS11510	COG2010	Cytochrome c
A8142_RS11515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8142_RS11520	COG0358	DNA primase activity
A8142_RS11535	COG0517	IMP dehydrogenase activity
A8142_RS11540	COG0751	glycine-tRNA ligase activity
A8142_RS11560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8142_RS11565	COG0295	cytidine deaminase activity
A8142_RS11570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8142_RS11580	COG1480	7TM receptor with intracellular HD hydrolase
A8142_RS11585	COG1702	phosphate starvation-inducible protein PhoH
A8142_RS11590	COG0561	phosphatase activity
A8142_RS11605	COG4864	UPF0365 protein
A8142_RS11610	COG1030	water channel activity
A8142_RS11615	COG1610	YqeY-like protein
A8142_RS11625	COG1283	sodium-dependent phosphate transmembrane transporter activity
A8142_RS11630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8142_RS11635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8142_RS11665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8142_RS11680	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS11695	COG1466	dna polymerase III delta subunit
A8142_RS11705	COG0658	competence protein
A8142_RS11705	COG2333	competence protein COMEC
A8142_RS11710	COG2131	deaminase
A8142_RS11715	COG1555	photosystem II stabilization
A8142_RS11715	COG1596	polysaccharide export
A8142_RS11720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8142_RS11725	COG2226	methyltransferase
A8142_RS11730	COG0799	negative regulation of ribosome biogenesis
A8142_RS11735	COG1713	HD superfamily hydrolase involved in NAD metabolism
A8142_RS11745	COG1534	Rna-binding protein
A8142_RS11750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8142_RS11755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8142_RS11760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A8142_RS11770	COG2755	lipolytic protein G-D-S-L family
A8142_RS11780	COG0398	Pfam SNARE associated Golgi protein
A8142_RS11800	COG3628	GPW Gp25 family protein
A8142_RS11805	COG1794	racemase activity, acting on amino acids and derivatives
A8142_RS11815	COG0656	L-ascorbic acid biosynthetic process
A8142_RS11840	COG3677	Transposase
A8142_RS11870	COG5002	protein histidine kinase activity
A8142_RS11870	COG0642	Histidine kinase
A8142_RS11875	COG0745	RESPONSE REGULATOR receiver
A8142_RS11880	COG2311	Membrane
A8142_RS11885	COG0454	-acetyltransferase
A8142_RS11890	COG0563	adenylate kinase activity
A8142_RS11900	COG2814	Major facilitator Superfamily
A8142_RS11905	COG0456	acetyltransferase
A8142_RS11910	COG2318	DinB family
A8142_RS11920	COG0561	phosphatase activity
A8142_RS11925	COG0561	phosphatase activity
A8142_RS11935	COG1482	cell wall glycoprotein biosynthetic process
A8142_RS11940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8142_RS11940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8142_RS11940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS11945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS11945	COG3711	transcriptional antiterminator
A8142_RS11955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8142_RS11960	COG0583	DNA-binding transcription factor activity
A8142_RS11965	COG2814	Major facilitator Superfamily
A8142_RS11970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8142_RS11970	COG2124	cytochrome p450
A8142_RS11975	COG1309	transcriptional regulator
A8142_RS11980	COG2226	methyltransferase
A8142_RS11995	COG2116	formate transmembrane transporter activity
A8142_RS12000	COG5609	conserved protein (DUF2294)
A8142_RS12005	COG3383	formate dehydrogenase (NAD+) activity
A8142_RS12010	COG2427	Protein of unknown function (DUF1641)
A8142_RS12020	COG0626	cystathionine gamma-synthase activity
A8142_RS12025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8142_RS12050	COG0768	penicillin binding
A8142_RS12065	COG0826	peptidase U32
A8142_RS12070	COG0826	peptidase U32
A8142_RS12075	COG4122	O-methyltransferase activity
A8142_RS12080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8142_RS12105	COG0628	permease
A8142_RS12110	COG1126	abc transporter atp-binding protein
A8142_RS12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8142_RS12120	COG0765	amino acid transport
A8142_RS12125	COG0765	amino acid transport
A8142_RS12140	COG3881	PFAM PRC-barrel domain
A8142_RS12145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8142_RS12150	COG0457	Tetratricopeptide repeat
A8142_RS12160	COG1104	cysteine desulfurase activity
A8142_RS12165	COG1959	2 iron, 2 sulfur cluster binding
A8142_RS12170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8142_RS12175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8142_RS12195	COG3103	Sh3 type 3 domain protein
A8142_RS12195	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS12195	COG4991	sh3 domain protein
A8142_RS12205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8142_RS12215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A8142_RS12215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8142_RS12220	COG5416	Lipopolysaccharide assembly protein A domain
A8142_RS12225	COG0490	domain, Protein
A8142_RS12230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8142_RS12230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8142_RS12240	COG2244	polysaccharide biosynthetic process
A8142_RS12245	COG2323	membrane
A8142_RS12255	COG1862	Preprotein translocase
A8142_RS12295	COG1388	LysM domain
A8142_RS12305	COG0157	Belongs to the NadC ModD family
A8142_RS12310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8142_RS12315	COG1104	cysteine desulfurase activity
A8142_RS12320	COG1827	regulation of RNA biosynthetic process
A8142_RS12325	COG0077	Prephenate dehydratase
A8142_RS12340	COG3290	protein histidine kinase activity
A8142_RS12345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8142_RS12350	COG2868	ribosomal protein
A8142_RS12360	COG1994	Peptidase M50
A8142_RS12365	COG0739	heme binding
A8142_RS12370	COG2894	cell division
A8142_RS12375	COG0850	regulation of cytokinetic process
A8142_RS12380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A8142_RS12390	COG1077	Cell shape determining protein MreB Mrl
A8142_RS12410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8142_RS12415	COG0285	dihydrofolate synthase activity
A8142_RS12420	COG0525	valine-tRNA ligase activity
A8142_RS12430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8142_RS12435	COG1388	LysM domain
A8142_RS12445	COG0113	porphobilinogen synthase activity
A8142_RS12450	COG1587	Uroporphyrinogen-III synthase
A8142_RS12460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8142_RS12480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8142_RS12485	COG0470	DNA polymerase III
A8142_RS12485	COG1067	ATP-dependent peptidase activity
A8142_RS12500	COG0457	Tetratricopeptide repeat
A8142_RS12500	COG1477	protein flavinylation
A8142_RS12515	COG0473	3-isopropylmalate dehydrogenase activity
A8142_RS12530	COG0440	acetolactate synthase activity
A8142_RS12535	COG0028	Belongs to the TPP enzyme family
A8142_RS12560	COG0622	Phosphoesterase
A8142_RS12565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8142_RS12575	COG5401	PFAM Sporulation and spore germination
A8142_RS12585	COG1846	Transcriptional regulator
A8142_RS12590	COG2197	response regulator
A8142_RS12595	COG0824	Thioesterase
A8142_RS12600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8142_RS12605	COG1053	succinate dehydrogenase
A8142_RS12610	COG2009	succinate dehydrogenase
A8142_RS12615	COG1719	4-vinyl reductase, 4VR
A8142_RS12620	COG0527	aspartate kinase activity
A8142_RS12630	COG3118	belongs to the thioredoxin family
A8142_RS12635	COG3534	alpha-L-arabinofuranosidase
A8142_RS12640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8142_RS12645	COG2086	electron transfer activity
A8142_RS12650	COG1024	Enoyl-CoA hydratase
A8142_RS12655	COG1309	transcriptional regulator
A8142_RS12660	COG0318	PFAM AMP-dependent synthetase and ligase
A8142_RS12670	COG3766	membrane
A8142_RS12680	COG1796	DNA polymerase
A8142_RS12680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8142_RS12685	COG1286	toxin biosynthetic process
A8142_RS12700	COG0072	phenylalanine-tRNA ligase activity
A8142_RS12700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8142_RS12705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8142_RS12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8142_RS12720	COG3835	regulator
A8142_RS12725	COG0277	FAD linked oxidase domain protein
A8142_RS12730	COG0247	lactate metabolic process
A8142_RS12735	COG1966	Carbon starvation protein
A8142_RS12740	COG3534	alpha-L-arabinofuranosidase
A8142_RS12745	COG0395	ABC-type sugar transport system, permease component
A8142_RS12750	COG1175	transmembrane transport
A8142_RS12755	COG1653	transport
A8142_RS12765	COG0647	UMP catabolic process
A8142_RS12770	COG0235	Class ii aldolase
A8142_RS12775	COG1069	ribulokinase activity
A8142_RS12780	COG2160	L-arabinose isomerase activity
A8142_RS12785	COG3507	Belongs to the glycosyl hydrolase 43 family
A8142_RS12790	COG1363	Peptidase, m42
A8142_RS12800	COG3326	Membrane
A8142_RS12815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8142_RS12820	COG1346	cytolysis
A8142_RS12825	COG1380	Effector of murein hydrolase LrgA
A8142_RS12830	COG3279	Response regulator of the LytR AlgR family
A8142_RS12835	COG3275	phosphorelay sensor kinase activity
A8142_RS12840	COG1011	Hydrolase
A8142_RS12855	COG0398	Pfam SNARE associated Golgi protein
A8142_RS12860	COG1484	DNA-dependent DNA replication
A8142_RS12865	COG3611	Membrane attachment protein
A8142_RS12880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8142_RS12885	COG1733	regulation of RNA biosynthetic process
A8142_RS12890	COG2814	Major facilitator Superfamily
A8142_RS12895	COG0656	L-ascorbic acid biosynthetic process
A8142_RS12900	COG0237	dephospho-CoA kinase activity
A8142_RS12905	COG1971	Probably functions as a manganese efflux pump
A8142_RS12910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8142_RS12915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8142_RS12915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8142_RS12920	COG5002	protein histidine kinase activity
A8142_RS12925	COG0745	RESPONSE REGULATOR receiver
A8142_RS12935	COG0538	isocitrate dehydrogenase activity
A8142_RS12940	COG0372	Belongs to the citrate synthase family
A8142_RS12960	COG0628	permease
A8142_RS12965	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8142_RS12970	COG0469	pyruvate kinase activity
A8142_RS12995	COG0281	malic enzyme
A8142_RS13000	COG0587	DNA-directed DNA polymerase activity
A8142_RS13020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8142_RS13030	COG4109	DRTGG domain
A8142_RS13040	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS13055	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8142_RS13065	COG0827	DNA restriction-modification system
A8142_RS13070	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8142_RS13075	COG3874	Sporulation protein YtfJ
A8142_RS13085	COG1714	RDD family
A8142_RS13090	COG0616	signal peptide processing
A8142_RS13095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8142_RS13100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A8142_RS13105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8142_RS13120	COG1104	cysteine desulfurase activity
A8142_RS13125	COG1114	Component of the transport system for branched-chain amino acids
A8142_RS13135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8142_RS13140	COG1309	transcriptional regulator
A8142_RS13145	COG1956	GAF domain-containing protein
A8142_RS13150	COG2203	Gaf domain
A8142_RS13150	COG2199	diguanylate cyclase activity
A8142_RS13160	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS13165	COG4282	regulation of fungal-type cell wall biogenesis
A8142_RS13200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8142_RS13200	COG1017	nitric oxide dioxygenase activity
A8142_RS13210	COG0693	protein deglycase activity
A8142_RS13225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8142_RS13230	COG1378	Sugar-specific transcriptional regulator TrmB
A8142_RS13250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8142_RS13255	COG0454	-acetyltransferase
A8142_RS13260	COG0517	IMP dehydrogenase activity
A8142_RS13265	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8142_RS13270	COG1360	Flagellar Motor Protein
A8142_RS13275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8142_RS13280	COG1609	Transcriptional regulator
A8142_RS13285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A8142_RS13285	COG1605	Chorismate mutase
A8142_RS13290	COG3118	belongs to the thioredoxin family
A8142_RS13295	COG4980	gas vesicle protein
A8142_RS13300	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A8142_RS13310	COG1674	ftsk spoiiie
A8142_RS13315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8142_RS13325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS13335	COG1363	Peptidase, m42
A8142_RS13340	COG5584	Small secreted protein
A8142_RS13345	COG0281	malic enzyme
A8142_RS13350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8142_RS13365	COG0510	thiamine kinase activity
A8142_RS13370	COG1597	lipid kinase activity
A8142_RS13380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A8142_RS13385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8142_RS13390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8142_RS13395	COG2252	PERMEase
A8142_RS13400	COG4473	ABC transporter
A8142_RS13405	COG1131	(ABC) transporter
A8142_RS13410	COG1349	DNA-binding transcription factor activity
A8142_RS13415	COG1187	pseudouridine synthase activity
A8142_RS13420	COG2244	polysaccharide biosynthetic process
A8142_RS13425	COG2081	HI0933 family
A8142_RS13430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8142_RS13440	COG1609	Transcriptional regulator
A8142_RS13445	COG1653	transport
A8142_RS13450	COG1175	transmembrane transport
A8142_RS13455	COG0395	ABC-type sugar transport system, permease component
A8142_RS13460	COG1486	melibiose metabolic process
A8142_RS13470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8142_RS13485	COG2202	Pas domain
A8142_RS13485	COG1366	Belongs to the anti-sigma-factor antagonist family
A8142_RS13490	COG2814	Major facilitator Superfamily
A8142_RS13495	COG5522	Integral membrane protein (intg_mem_TP0381)
A8142_RS13500	COG0577	efflux transmembrane transporter activity
A8142_RS13505	COG1136	(ABC) transporter
A8142_RS13510	COG2205	protein histidine kinase activity
A8142_RS13515	COG0745	RESPONSE REGULATOR receiver
A8142_RS13520	COG0577	efflux transmembrane transporter activity
A8142_RS13525	COG1136	(ABC) transporter
A8142_RS13545	COG1131	(ABC) transporter
A8142_RS13550	COG1725	Transcriptional regulator
A8142_RS13560	COG1242	4 iron, 4 sulfur cluster binding
A8142_RS13565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A8142_RS13575	COG0584	glycerophosphoryl diester phosphodiesterase
A8142_RS13585	COG2267	carboxylic ester hydrolase activity
A8142_RS13590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8142_RS13595	COG1113	amino acid transport
A8142_RS13600	COG0367	asparagine synthase
A8142_RS13620	COG1506	peptidase
A8142_RS13625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8142_RS13630	COG1116	anion transmembrane transporter activity
A8142_RS13635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8142_RS13640	COG0494	nUDIX hydrolase
A8142_RS13645	COG4824	toxin secretion phage lysis holin
A8142_RS13650	COG0783	Belongs to the Dps family
A8142_RS13675	COG0288	reversible hydration of carbon dioxide
A8142_RS13685	COG1271	oxidase subunit
A8142_RS13690	COG1294	oxidase, subunit
A8142_RS13705	COG4948	Mandelate Racemase Muconate Lactonizing
A8142_RS13715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8142_RS13720	COG0596	Alpha beta hydrolase
A8142_RS13730	COG1169	isochorismate synthase
A8142_RS13735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8142_RS13740	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A8142_RS13865	COG3859	Proton-coupled thiamine transporter YuaJ
A8142_RS13870	COG2268	Band 7 protein
A8142_RS13875	COG1585	Membrane protein implicated in regulation of membrane protease activity
A8142_RS13880	COG2318	DinB family
A8142_RS13890	COG1454	alcohol dehydrogenase
A8142_RS13895	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS13900	COG1510	regulation of RNA biosynthetic process
A8142_RS13910	COG0569	domain protein
A8142_RS13915	COG1705	Flagellar rod assembly protein muramidase FlgJ
A8142_RS13920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8142_RS13920	COG1017	nitric oxide dioxygenase activity
A8142_RS13945	COG0628	permease
A8142_RS13950	COG0673	inositol 2-dehydrogenase activity
A8142_RS13955	COG0693	protein deglycase activity
A8142_RS13960	COG0840	transmembrane signaling receptor activity
A8142_RS13965	COG0840	transmembrane signaling receptor activity
A8142_RS13970	COG0840	transmembrane signaling receptor activity
A8142_RS13975	COG0840	transmembrane signaling receptor activity
A8142_RS13990	COG2070	2-Nitropropane dioxygenase
A8142_RS13995	COG0432	Pfam Uncharacterised protein family UPF0047
A8142_RS14000	COG0366	Alpha amylase catalytic
A8142_RS14005	COG1253	flavin adenine dinucleotide binding
A8142_RS14010	COG2738	Putative neutral zinc metallopeptidase
A8142_RS14025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8142_RS14050	COG1335	isochorismatase
A8142_RS14055	COG1979	alcohol dehydrogenase
A8142_RS14060	COG1979	alcohol dehydrogenase
A8142_RS14065	COG2155	Conserved Protein
A8142_RS14070	COG1098	S1 RNA binding domain
A8142_RS14075	COG0436	Aminotransferase
A8142_RS14080	COG1522	sequence-specific DNA binding
A8142_RS14085	COG2267	carboxylic ester hydrolase activity
A8142_RS14095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8142_RS14100	COG2205	protein histidine kinase activity
A8142_RS14110	COG5018	Exonuclease
A8142_RS14115	COG2814	Major facilitator Superfamily
A8142_RS14120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8142_RS14125	COG3011	Protein conserved in bacteria
A8142_RS14135	COG3290	protein histidine kinase activity
A8142_RS14140	COG4565	transcriptional regulatory protein
A8142_RS14145	COG1744	ABC transporter substrate-binding protein PnrA-like
A8142_RS14150	COG3845	ABC transporter
A8142_RS14155	COG4603	Belongs to the binding-protein-dependent transport system permease family
A8142_RS14160	COG1079	Belongs to the binding-protein-dependent transport system permease family
A8142_RS14170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8142_RS14170	COG2111	Na H antiporter
A8142_RS14175	COG2111	Na H antiporter
A8142_RS14180	COG1006	Multisubunit Na H antiporter MnhC subunit
A8142_RS14185	COG0651	ATP synthesis coupled electron transport
A8142_RS14190	COG1863	multisubunit Na H antiporter MnhE subunit
A8142_RS14195	COG2212	antiporter activity
A8142_RS14200	COG1320	monovalent cation:proton antiporter activity
A8142_RS14205	COG2050	protein possibly involved in aromatic compounds catabolism
A8142_RS14210	COG2197	response regulator
A8142_RS14215	COG4585	Histidine kinase
A8142_RS14240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A8142_RS14245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8142_RS14250	COG1335	isochorismatase
A8142_RS14255	COG5506	Protein of unknown function (DUF1694)
A8142_RS14270	COG0628	permease
A8142_RS14280	COG1418	mRNA catabolic process
A8142_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS14295	COG1511	domain protein
A8142_RS14300	COG0433	COG0433 Predicted ATPase
A8142_RS14300	COG1674	ftsk spoiiie
A8142_RS14305	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8142_RS14310	COG5417	Belongs to the EsaB family
A8142_RS14315	COG4842	Belongs to the WXG100 family
A8142_RS14320	COG2508	Transcriptional regulator
A8142_RS14320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A8142_RS14325	COG0686	Belongs to the AlaDH PNT family
A8142_RS14330	COG5634	Uncharacterized conserved protein (DUF2278)
A8142_RS14335	COG3251	PFAM MbtH domain protein
A8142_RS14340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8142_RS14345	COG1535	isochorismatase
A8142_RS14345	COG3433	isochorismatase activity
A8142_RS14350	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8142_RS14355	COG1169	isochorismate synthase
A8142_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS14365	COG2819	hydrolase of the alpha beta superfamily
A8142_RS14370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8142_RS14375	COG1268	BioY protein
A8142_RS14380	COG2056	Na+-H+ antiporter family
A8142_RS14390	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A8142_RS14395	COG3584	3D domain protein
A8142_RS14405	COG1252	NADH dehydrogenase
A8142_RS14435	COG1131	(ABC) transporter
A8142_RS14455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8142_RS14460	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A8142_RS14465	COG0316	Belongs to the HesB IscA family
A8142_RS14475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8142_RS14485	COG1252	NADH dehydrogenase
A8142_RS14490	COG4837	Protein of unknown function (DUF1462)
A8142_RS14495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8142_RS14500	COG0823	Involved in the tonB-independent uptake of proteins
A8142_RS14500	COG1506	peptidase
A8142_RS14500	COG4946	Tricorn protease homolog
A8142_RS14510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A8142_RS14515	COG0460	homoserine dehydrogenase
A8142_RS14520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8142_RS14525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8142_RS14530	COG0647	UMP catabolic process
A8142_RS14535	COG2445	Protein of unknown function DUF86
A8142_RS14540	COG4470	Protein conserved in bacteria
A8142_RS14550	COG0739	heme binding
A8142_RS14560	COG0737	Belongs to the 5'-nucleotidase family
A8142_RS14565	COG0730	response to heat
A8142_RS14570	COG1801	Protein of unknown function DUF72
A8142_RS14585	COG2508	Transcriptional regulator
A8142_RS14610	COG2814	Major facilitator Superfamily
A8142_RS14615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8142_RS14620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8142_RS14625	COG2356	endonuclease I
A8142_RS14630	COG3842	ATPase activity
A8142_RS14635	COG2188	Transcriptional regulator
A8142_RS14640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8142_RS14645	COG0395	ABC-type sugar transport system, permease component
A8142_RS14650	COG1175	transmembrane transport
A8142_RS14655	COG1653	transport
A8142_RS14660	COG2222	sugar isomerase
A8142_RS14665	COG0789	Transcriptional regulator
A8142_RS14690	COG0322	excinuclease ABC activity
A8142_RS14695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8142_RS14715	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS14720	COG0719	Fe-S assembly protein
A8142_RS14725	COG0822	iron-sulfur transferase activity
A8142_RS14730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8142_RS14735	COG0719	Fe-S assembly protein
A8142_RS14740	COG0396	ATPase activity
A8142_RS14745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8142_RS14750	COG1464	Belongs to the NlpA lipoprotein family
A8142_RS14755	COG2011	ABC-type metal ion transport system permease component
A8142_RS14760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8142_RS14770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8142_RS14775	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8142_RS14790	COG1393	Belongs to the ArsC family
A8142_RS14795	COG1960	acyl-CoA dehydrogenase activity
A8142_RS14800	COG0183	Belongs to the thiolase family
A8142_RS14805	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8142_RS14805	COG1024	Enoyl-CoA hydratase
A8142_RS14825	COG5577	PFAM Coat F domain
A8142_RS14830	COG1846	Transcriptional regulator
A8142_RS14835	COG0477	Major facilitator Superfamily
A8142_RS14840	COG1942	4-Oxalocrotonate Tautomerase
A8142_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS14850	COG0583	DNA-binding transcription factor activity
A8142_RS14855	COG0583	DNA-binding transcription factor activity
A8142_RS14880	COG1120	ATPase activity
A8142_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS14900	COG0783	Belongs to the Dps family
A8142_RS14905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8142_RS14910	COG0745	RESPONSE REGULATOR receiver
A8142_RS14915	COG2770	Histidine kinase
A8142_RS14915	COG2205	protein histidine kinase activity
A8142_RS14920	COG1309	transcriptional regulator
A8142_RS14925	COG0114	fumarate hydratase activity
A8142_RS14935	COG0697	spore germination
A8142_RS14940	COG0814	amino acid
A8142_RS14950	COG2197	response regulator
A8142_RS14955	COG4585	Histidine kinase
A8142_RS14960	COG4758	membrane
A8142_RS14965	COG3595	metallopeptidase activity
A8142_RS14970	COG1842	Phage shock protein A
A8142_RS14975	COG4758	membrane
A8142_RS14980	COG2814	Major facilitator Superfamily
A8142_RS14985	COG2096	Adenosyltransferase
A8142_RS14990	COG1120	ATPase activity
A8142_RS14995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS15000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8142_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS15010	COG3386	PFAM SMP-30 Gluconolaconase
A8142_RS15015	COG2205	protein histidine kinase activity
A8142_RS15020	COG0745	RESPONSE REGULATOR receiver
A8142_RS15030	COG1191	sigma factor activity
A8142_RS15040	COG2140	Oxalate decarboxylase
A8142_RS15050	COG1120	ATPase activity
A8142_RS15055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS15060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS15065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8142_RS15070	COG0531	amino acid
A8142_RS15080	COG1988	membrane-bound metal-dependent
A8142_RS15085	COG1368	sulfuric ester hydrolase activity
A8142_RS15090	COG1910	domain protein
A8142_RS15095	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8142_RS15100	COG4149	molybdate abc transporter
A8142_RS15105	COG2197	response regulator
A8142_RS15110	COG3850	Histidine kinase
A8142_RS15115	COG1131	(ABC) transporter
A8142_RS15125	COG0842	Transport permease protein
A8142_RS15130	COG0656	L-ascorbic acid biosynthetic process
A8142_RS15155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8142_RS15160	COG3973	AAA domain
A8142_RS15165	COG2860	membrane
A8142_RS15175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8142_RS15180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8142_RS15185	COG2217	Heavy metal translocating P-type atpase
A8142_RS15190	COG2217	Heavy metal translocating P-type atpase
A8142_RS15195	COG2608	mercury ion transmembrane transporter activity
A8142_RS15200	COG1937	Protein conserved in bacteria
A8142_RS15205	COG0673	inositol 2-dehydrogenase activity
A8142_RS15215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS15220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8142_RS15225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS15230	COG1126	abc transporter atp-binding protein
A8142_RS15235	COG0765	amino acid transport
A8142_RS15240	COG0765	amino acid transport
A8142_RS15245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8142_RS15250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8142_RS15255	COG0454	-acetyltransferase
A8142_RS15260	COG0583	DNA-binding transcription factor activity
A8142_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS15295	COG4974	Belongs to the 'phage' integrase family
A8142_RS15310	COG0557	exoribonuclease II activity
A8142_RS15315	COG1647	Serine aminopeptidase, S33
A8142_RS15320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8142_RS15325	COG1476	TRANSCRIPTIONal
A8142_RS15330	COG1396	sequence-specific DNA binding
A8142_RS15335	COG1396	sequence-specific DNA binding
A8142_RS15340	COG1733	regulation of RNA biosynthetic process
A8142_RS15365	COG1131	(ABC) transporter
A8142_RS15370	COG1174	glycine betaine transport
A8142_RS15375	COG1732	Glycine betaine
A8142_RS15380	COG1174	glycine betaine transport
A8142_RS15385	COG1125	glycine betaine transport
A8142_RS15385	COG0517	IMP dehydrogenase activity
A8142_RS15390	COG1510	regulation of RNA biosynthetic process
A8142_RS15395	COG1174	glycine betaine transport
A8142_RS15400	COG1732	Glycine betaine
A8142_RS15405	COG1174	glycine betaine transport
A8142_RS15410	COG1125	glycine betaine transport
A8142_RS15410	COG0517	IMP dehydrogenase activity
A8142_RS15415	COG1510	regulation of RNA biosynthetic process
A8142_RS15420	COG2095	MarC family integral membrane protein
A8142_RS15425	COG3064	Membrane
A8142_RS15430	COG4640	response to antibiotic
A8142_RS15435	COG0456	acetyltransferase
A8142_RS15450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8142_RS15470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8142_RS15475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8142_RS15485	COG2234	aminopeptidase activity
A8142_RS15505	COG0126	phosphoglycerate kinase activity
A8142_RS15515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8142_RS15520	COG2390	Transcriptional regulator
A8142_RS15525	COG2814	Major facilitator Superfamily
A8142_RS15530	COG1609	Transcriptional regulator
A8142_RS15535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS15545	COG0583	DNA-binding transcription factor activity
A8142_RS15550	COG0697	spore germination
A8142_RS15555	COG1113	amino acid transport
A8142_RS15560	COG1609	Transcriptional regulator
A8142_RS15570	COG0561	phosphatase activity
A8142_RS15575	COG1737	Transcriptional regulator
A8142_RS15580	COG1070	Carbohydrate kinase
A8142_RS15615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS15620	COG2186	Transcriptional regulator
A8142_RS15625	COG1620	l-lactate permease
A8142_RS15630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8142_RS15640	COG5039	Polysaccharide pyruvyl transferase
A8142_RS15645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8142_RS15650	COG0110	maltose O-acetyltransferase activity
A8142_RS15655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8142_RS15660	COG2244	polysaccharide biosynthetic process
A8142_RS15665	COG1216	Glycosyl transferase, family 2
A8142_RS15670	COG5039	Polysaccharide pyruvyl transferase
A8142_RS15675	COG1216	Glycosyl transferase, family 2
A8142_RS15685	COG0438	transferase activity, transferring glycosyl groups
A8142_RS15690	COG1215	transferase activity, transferring glycosyl groups
A8142_RS15695	COG0438	transferase activity, transferring glycosyl groups
A8142_RS15700	COG1086	Polysaccharide biosynthesis protein
A8142_RS15705	COG0489	protein tyrosine kinase activity
A8142_RS15710	COG3944	biosynthesis protein
A8142_RS15715	COG1396	sequence-specific DNA binding
A8142_RS15720	COG2272	Belongs to the type-B carboxylesterase lipase family
A8142_RS15725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8142_RS15730	COG2364	Membrane
A8142_RS15735	COG0456	acetyltransferase
A8142_RS15740	COG3479	Phenolic acid decarboxylase
A8142_RS15785	COG2223	nitrite transmembrane transporter activity
A8142_RS15790	COG1609	Transcriptional regulator
A8142_RS15800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8142_RS15805	COG0366	Alpha amylase catalytic
A8142_RS15810	COG1554	hydrolase, family 65, central catalytic
A8142_RS15815	COG5521	maltodextrose utilization protein MalA
A8142_RS15820	COG3833	ABC-type maltose transport systems, permease component
A8142_RS15825	COG1175	transmembrane transport
A8142_RS15830	COG2182	Extracellular solute-binding protein
A8142_RS15835	COG0366	Alpha amylase catalytic
A8142_RS15840	COG1609	Transcriptional regulator
A8142_RS15845	COG1611	Belongs to the LOG family
A8142_RS15850	COG1694	Mazg nucleotide pyrophosphohydrolase
A8142_RS15855	COG0659	secondary active sulfate transmembrane transporter activity
A8142_RS15860	COG0288	reversible hydration of carbon dioxide
A8142_RS15870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8142_RS15875	COG4290	ribonuclease
A8142_RS15880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A8142_RS15885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS15895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8142_RS15905	COG1051	belongs to the nudix hydrolase family
A8142_RS15910	COG0492	ferredoxin-NADP+ reductase activity
A8142_RS15915	COG0791	NLP P60 protein
A8142_RS15915	COG3883	PFAM NLP P60 protein
A8142_RS15920	COG0457	Tetratricopeptide repeat
A8142_RS15925	COG5002	protein histidine kinase activity
A8142_RS15930	COG0745	RESPONSE REGULATOR receiver
A8142_RS15935	COG1132	(ABC) transporter
A8142_RS15940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8142_RS15940	COG0140	phosphoribosyl-ATP diphosphatase activity
A8142_RS15965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8142_RS15980	COG4990	cell redox homeostasis
A8142_RS15985	COG0110	maltose O-acetyltransferase activity
A8142_RS16005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8142_RS16015	COG2188	Transcriptional regulator
A8142_RS16020	COG1309	transcriptional regulator
A8142_RS16025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8142_RS16030	COG1950	PFAM Membrane protein of
A8142_RS16035	COG1983	PspC domain protein
A8142_RS16040	COG3595	metallopeptidase activity
A8142_RS16055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8142_RS16065	COG4897	Protein conserved in bacteria
A8142_RS16070	COG3848	Pyruvate phosphate dikinase
A8142_RS16070	COG0574	Belongs to the PEP-utilizing enzyme family
A8142_RS16075	COG1309	transcriptional regulator
A8142_RS16080	COG2814	Major facilitator Superfamily
A8142_RS16095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8142_RS16105	COG3409	Peptidoglycan-binding domain 1 protein
A8142_RS16105	COG0793	Belongs to the peptidase S41A family
A8142_RS16110	COG3420	alginic acid biosynthetic process
A8142_RS16115	COG2177	Part of the ABC transporter FtsEX involved in
A8142_RS16120	COG2884	Cell division ATP-binding protein ftsE
A8142_RS16125	COG2010	Cytochrome c
A8142_RS16130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS16135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8142_RS16145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8142_RS16160	COG1516	flagellar protein fliS
A8142_RS16165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A8142_RS16170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8142_RS16190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8142_RS16195	COG1256	bacterial-type flagellum assembly
A8142_RS16195	COG4786	Flagellar basal body rod
A8142_RS16200	COG3418	PFAM FlgN family protein
A8142_RS16205	COG2747	anti-sigma28 factor FlgM
A8142_RS16215	COG1040	competence protein
A8142_RS16225	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A8142_RS16230	COG1307	EDD domain protein, DegV family
A8142_RS16235	COG2197	response regulator
A8142_RS16240	COG4585	Histidine kinase
A8142_RS16245	COG1739	Uncharacterized protein family UPF0029
A8142_RS16250	COG1316	TRANSCRIPTIONal
A8142_RS16255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8142_RS16260	COG0438	transferase activity, transferring glycosyl groups
A8142_RS16265	COG1215	transferase activity, transferring glycosyl groups
A8142_RS16270	COG3206	protein involved in exopolysaccharide biosynthesis
A8142_RS16275	COG3307	-O-antigen
A8142_RS16280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8142_RS16285	COG0438	transferase activity, transferring glycosyl groups
A8142_RS16285	COG0297	glycogen (starch) synthase activity
A8142_RS16290	COG2244	polysaccharide biosynthetic process
A8142_RS16300	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8142_RS16300	COG2247	cell wall binding repeat
A8142_RS16305	COG2385	sporulation resulting in formation of a cellular spore
A8142_RS16305	COG2247	cell wall binding repeat
A8142_RS16315	COG1316	TRANSCRIPTIONal
A8142_RS16320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8142_RS16325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8142_RS16330	COG1134	teichoic acid transport
A8142_RS16335	COG1682	transport, permease protein
A8142_RS16340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8142_RS16350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8142_RS16355	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8142_RS16360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8142_RS16365	COG4193	domain, Protein
A8142_RS16370	COG1482	cell wall glycoprotein biosynthetic process
A8142_RS16375	COG0697	spore germination
A8142_RS16380	COG0814	amino acid
A8142_RS16390	COG1215	transferase activity, transferring glycosyl groups
A8142_RS16395	COG2814	Major facilitator Superfamily
A8142_RS16400	COG1316	TRANSCRIPTIONal
A8142_RS16405	COG0561	phosphatase activity
A8142_RS16410	COG2433	Pfam Transposase IS66
A8142_RS16415	COG0791	NLP P60 protein
A8142_RS16420	COG2843	Capsule synthesis protein
A8142_RS16430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8142_RS16435	COG0697	spore germination
A8142_RS16440	COG0814	amino acid
A8142_RS16450	COG1609	Transcriptional regulator
A8142_RS16455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8142_RS16465	COG1129	ABC transporter
A8142_RS16470	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8142_RS16475	COG1879	ABC-type sugar transport system periplasmic component
A8142_RS16480	COG3103	Sh3 type 3 domain protein
A8142_RS16485	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8142_RS16490	COG3527	Alpha-acetolactate decarboxylase
A8142_RS16495	COG0028	Belongs to the TPP enzyme family
A8142_RS16500	COG0583	DNA-binding transcription factor activity
A8142_RS16505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8142_RS16520	COG5337	Spore coat protein CotH
A8142_RS16530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8142_RS16535	COG0405	Gamma-glutamyltransferase
A8142_RS16540	COG1522	sequence-specific DNA binding
A8142_RS16545	COG2059	Chromate
A8142_RS16550	COG2059	Chromate
A8142_RS16560	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8142_RS16565	COG0583	DNA-binding transcription factor activity
A8142_RS16600	COG5444	nuclease activity
A8142_RS16615	COG3878	Protein conserved in bacteria
A8142_RS16620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8142_RS16625	COG4464	protein tyrosine phosphatase activity
A8142_RS16630	COG0489	protein tyrosine kinase activity
A8142_RS16635	COG3944	biosynthesis protein
A8142_RS16640	COG4715	Zinc finger, swim domain protein
A8142_RS16645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8142_RS16650	COG0561	phosphatase activity
A8142_RS16655	COG1349	DNA-binding transcription factor activity
A8142_RS16660	COG0629	single-stranded DNA binding
A8142_RS16685	COG0457	Tetratricopeptide repeat
A8142_RS16690	COG4786	Flagellar basal body rod
A8142_RS16695	COG4786	Flagellar basal body rod
A8142_RS16700	COG1077	Cell shape determining protein MreB Mrl
A8142_RS16705	COG1609	Transcriptional regulator
A8142_RS16710	COG1846	Transcriptional regulator
A8142_RS16715	COG2814	Major facilitator Superfamily
A8142_RS16720	COG1953	Uracil, thiamine, allantoin
A8142_RS16725	COG0477	Major facilitator Superfamily
A8142_RS16730	COG1335	isochorismatase
A8142_RS16735	COG0004	ammonium transporteR
A8142_RS16740	COG0347	Belongs to the P(II) protein family
A8142_RS16745	COG0772	Belongs to the SEDS family
A8142_RS16750	COG0671	phosphoesterase, PA-phosphatase related
A8142_RS16760	COG0739	heme binding
A8142_RS16765	COG1247	-acetyltransferase
A8142_RS16780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8142_RS16795	COG0726	polysaccharide deacetylase
A8142_RS16805	COG1959	2 iron, 2 sulfur cluster binding
A8142_RS16820	COG0831	urea catabolic process
A8142_RS16825	COG3237	CsbD-like
A8142_RS16830	COG1994	Peptidase M50
A8142_RS16835	COG0457	Tetratricopeptide repeat
A8142_RS16845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8142_RS16850	COG2304	oxidoreductase activity
A8142_RS16855	COG2304	oxidoreductase activity
A8142_RS16860	COG2385	sporulation resulting in formation of a cellular spore
A8142_RS16865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8142_RS16875	COG4836	Membrane
A8142_RS16945	COG0698	ribose 5-phosphate isomerase
A8142_RS16950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8142_RS16960	COG0009	L-threonylcarbamoyladenylate synthase
A8142_RS16965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A8142_RS16985	COG2890	protein-(glutamine-N5) methyltransferase activity
A8142_RS16990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8142_RS16995	COG0346	lactoylglutathione lyase activity
A8142_RS17000	COG0789	Transcriptional regulator
A8142_RS17005	COG0679	Auxin Efflux Carrier
A8142_RS17010	COG0281	malic enzyme
A8142_RS17025	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8142_RS17030	COG1494	fructose-1,6-bisphosphatase
A8142_RS17035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8142_RS17050	COG0191	fructose-bisphosphate aldolase activity
A8142_RS17055	COG2204	response regulator
A8142_RS17060	COG4821	SIS domain
A8142_RS17075	COG2181	nitrate reductase activity
A8142_RS17075	COG0247	lactate metabolic process
A8142_RS17080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8142_RS17095	COG1132	(ABC) transporter
A8142_RS17100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8142_RS17110	COG2181	nitrate reductase activity
A8142_RS17115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A8142_RS17120	COG1140	nitrate reductase beta subunit
A8142_RS17125	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A8142_RS17130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8142_RS17140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8142_RS17145	COG2223	nitrite transmembrane transporter activity
A8142_RS17155	COG4506	Protein conserved in bacteria
A8142_RS17165	COG3391	amine dehydrogenase activity
A8142_RS17170	COG3391	amine dehydrogenase activity
A8142_RS17175	COG0457	Tetratricopeptide repeat
A8142_RS17180	COG0010	Belongs to the arginase family
A8142_RS17185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A8142_RS17190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8142_RS17205	COG1994	Peptidase M50
A8142_RS17210	COG1942	4-Oxalocrotonate Tautomerase
A8142_RS17215	COG1846	Transcriptional regulator
A8142_RS17220	COG0531	amino acid
A8142_RS17225	COG3465	dGTPase activity
A8142_RS17230	COG1078	dGTPase activity
A8142_RS17245	COG1695	Transcriptional regulator
A8142_RS17255	COG1131	(ABC) transporter
A8142_RS17260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8142_RS17290	COG0583	DNA-binding transcription factor activity
A8142_RS17295	COG2855	membrane
A8142_RS17300	COG0280	phosphate acetyltransferase
A8142_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS17315	COG0436	Aminotransferase
A8142_RS17345	COG2814	Major facilitator Superfamily
A8142_RS17350	COG2814	Major facilitator Superfamily
A8142_RS17355	COG0833	amino acid
A8142_RS17360	COG4187	Peptidase family M20/M25/M40
A8142_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS17370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8142_RS17375	COG2205	protein histidine kinase activity
A8142_RS17380	COG0745	RESPONSE REGULATOR receiver
A8142_RS17395	COG1131	(ABC) transporter
A8142_RS17400	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A8142_RS17405	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8142_RS17410	COG1088	dTDP-glucose 4,6-dehydratase activity
A8142_RS17415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8142_RS17420	COG3980	spore coat polysaccharide biosynthesis protein
A8142_RS17425	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
A8142_RS17430	COG2089	acid synthase
A8142_RS17435	COG0456	acetyltransferase
A8142_RS17440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A8142_RS17445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8142_RS17450	COG0463	Glycosyl transferase, family 2
A8142_RS17460	COG2363	Small membrane protein
A8142_RS17465	COG2233	PERMEase
A8142_RS17480	COG1216	Glycosyl transferase, family 2
A8142_RS17495	COG1695	Transcriptional regulator
A8142_RS17500	COG0351	phosphomethylpyrimidine kinase
A8142_RS17510	COG1621	beta-fructofuranosidase activity
A8142_RS17515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8142_RS17515	COG1263	PTS System
A8142_RS17520	COG3711	transcriptional antiterminator
A8142_RS17530	COG1404	Belongs to the peptidase S8 family
A8142_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8142_RS17540	COG0778	Nitroreductase
A8142_RS17545	COG0772	Belongs to the SEDS family
A8142_RS17550	COG0454	-acetyltransferase
A8142_RS17570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8142_RS17575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8142_RS17580	COG2261	transglycosylase associated protein
A8142_RS17585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A8142_RS17590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8142_RS17595	COG2246	polysaccharide biosynthetic process
A8142_RS17600	COG1309	transcriptional regulator
A8142_RS17620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8142_RS17625	COG2837	iron assimilation
A8142_RS17640	COG0583	DNA-binding transcription factor activity
A8142_RS17650	COG1346	cytolysis
A8142_RS17655	COG4895	conserved protein (DUF2196)
A8142_RS17660	COG0789	Transcriptional regulator
A8142_RS17665	COG5504	Zn-dependent protease
A8142_RS17670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8142_RS17675	COG0346	lactoylglutathione lyase activity
A8142_RS17680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS17685	COG1404	Belongs to the peptidase S8 family
A8142_RS17690	COG1442	glycosyl transferase family 8
A8142_RS17695	COG2357	RelA SpoT domain protein
A8142_RS17700	COG1575	Belongs to the MenA family. Type 1 subfamily
A8142_RS17715	COG1696	Membrane protein involved in D-alanine export
A8142_RS17725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A8142_RS17730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8142_RS17735	COG1486	melibiose metabolic process
A8142_RS17740	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8142_RS17745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS17750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS17755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8142_RS17755	COG3711	transcriptional antiterminator
A8142_RS17765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8142_RS17780	COG0640	Transcriptional regulator
A8142_RS17785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8142_RS17790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS17795	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8142_RS17800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8142_RS17805	COG2723	6-phospho-beta-galactosidase activity
A8142_RS17815	COG1482	cell wall glycoprotein biosynthetic process
A8142_RS17825	COG0753	catalase activity
A8142_RS17830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A8142_RS17835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A8142_RS17855	COG3279	Response regulator of the LytR AlgR family
A8142_RS17875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8142_RS17880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8142_RS17885	COG4988	ABC transporter
A8142_RS17890	COG1294	oxidase, subunit
A8142_RS17895	COG1271	oxidase subunit
A8142_RS17900	COG3493	citrate carrier protein
A8142_RS17905	COG0726	polysaccharide deacetylase
A8142_RS17910	COG3842	ATPase activity
A8142_RS17915	COG2508	Transcriptional regulator
A8142_RS17920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS17930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8142_RS17940	COG4894	glucomannan catabolic process
A8142_RS17945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8142_RS17950	COG0500	methyltransferase
A8142_RS17955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8142_RS17970	COG0753	catalase activity
A8142_RS17970	COG0693	protein deglycase activity
A8142_RS17975	COG2851	Citrate transporter
A8142_RS17980	COG2273	Hydrolase Family 16
A8142_RS17985	COG2270	Major facilitator Superfamily
A8142_RS17990	COG0513	Belongs to the DEAD box helicase family
A8142_RS18000	COG0697	spore germination
A8142_RS18005	COG0589	response to stress
A8142_RS18010	COG2723	6-phospho-beta-galactosidase activity
A8142_RS18060	COG3507	Belongs to the glycosyl hydrolase 43 family
A8142_RS18090	COG0010	Belongs to the arginase family
A8142_RS18095	COG0833	amino acid
A8142_RS18100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A8142_RS18105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8142_RS18115	COG2390	Transcriptional regulator
A8142_RS18120	COG0561	phosphatase activity
A8142_RS18150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8142_RS18155	COG5294	Protein conserved in bacteria
A8142_RS18160	COG0577	efflux transmembrane transporter activity
A8142_RS18165	COG1136	(ABC) transporter
A8142_RS18170	COG2205	protein histidine kinase activity
A8142_RS18175	COG0745	RESPONSE REGULATOR receiver
A8142_RS18180	COG2205	protein histidine kinase activity
A8142_RS18185	COG0745	RESPONSE REGULATOR receiver
A8142_RS18215	COG1082	Xylose isomerase domain protein TIM barrel
A8142_RS18225	COG2814	Major facilitator Superfamily
A8142_RS18255	COG1349	DNA-binding transcription factor activity
A8142_RS18260	COG0667	Aldo Keto reductase
A8142_RS18265	COG2814	Major facilitator Superfamily
A8142_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS18285	COG2197	response regulator
A8142_RS18290	COG4585	Histidine kinase
A8142_RS18295	COG3239	Fatty acid desaturase
A8142_RS18300	COG1309	transcriptional regulator
A8142_RS18305	COG1012	belongs to the aldehyde dehydrogenase family
A8142_RS18310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8142_RS18320	COG0640	Transcriptional regulator
A8142_RS18325	COG2814	Major facilitator Superfamily
A8142_RS18330	COG1714	RDD family
A8142_RS18340	COG0450	alkyl hydroperoxide reductase
A8142_RS18345	COG3634	alkyl hydroperoxide reductase activity
A8142_RS18350	COG3177	Filamentation induced by cAMP protein fic
A8142_RS18355	COG1113	amino acid transport
A8142_RS18365	COG2080	2 iron, 2 sulfur cluster binding
A8142_RS18380	COG2068	MobA-Related Protein
A8142_RS18385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A8142_RS18440	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A8142_RS18445	COG0667	Aldo Keto reductase
A8142_RS18450	COG0456	acetyltransferase
A8142_RS18455	COG0457	Tetratricopeptide repeat
A8142_RS18460	COG0010	Belongs to the arginase family
A8142_RS18465	COG0833	amino acid
A8142_RS18470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8142_RS18475	COG5658	integral membrane protein
A8142_RS18480	COG0640	Transcriptional regulator
A8142_RS18485	COG3829	transcription factor binding
A8142_RS18495	COG0488	(ABC) transporter
A8142_RS18510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8142_RS18515	COG5002	protein histidine kinase activity
A8142_RS18515	COG3850	Histidine kinase
A8142_RS18520	COG0745	RESPONSE REGULATOR receiver
A8142_RS18525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8142_RS18530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8142_RS18535	COG4853	Protein conserved in bacteria
A8142_RS18540	COG4863	YycH protein
A8142_RS18545	COG5002	protein histidine kinase activity
A8142_RS18550	COG0745	RESPONSE REGULATOR receiver
A8142_RS18585	COG0346	lactoylglutathione lyase activity
A8142_RS18590	COG0305	Participates in initiation and elongation during chromosome replication
A8142_RS18605	COG3093	addiction module antidote protein HigA
A8142_RS18610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8142_RS18615	COG0297	glycogen (starch) synthase activity
A8142_RS18625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A8142_RS18630	COG0438	transferase activity, transferring glycosyl groups
A8142_RS18650	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A8142_RS18655	COG4241	membrane
A8142_RS18660	COG5577	PFAM Coat F domain
A8142_RS18665	COG1733	regulation of RNA biosynthetic process
A8142_RS18675	COG0697	spore germination
A8142_RS18680	COG1621	beta-fructofuranosidase activity
A8142_RS18685	COG1621	beta-fructofuranosidase activity
A8142_RS18695	COG2318	DinB family
A8142_RS18700	COG2211	Major facilitator Superfamily
A8142_RS18710	COG0778	Nitroreductase
A8142_RS18715	COG1846	Transcriptional regulator
A8142_RS18720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8142_RS18725	COG1846	Transcriptional regulator
A8142_RS18730	COG2153	protein acetylation
A8142_RS18740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8142_RS18745	COG0583	DNA-binding transcription factor activity
A8142_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
A8142_RS18755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8142_RS18760	COG0697	spore germination
A8142_RS18785	COG1331	Highly conserved protein containing a thioredoxin domain
A8142_RS18790	COG1266	CAAX protease self-immunity
A8142_RS18795	COG2814	Major facilitator Superfamily
A8142_RS18795	COG0477	Major facilitator Superfamily
A8142_RS18800	COG0346	lactoylglutathione lyase activity
A8142_RS18805	COG1609	Transcriptional regulator
A8142_RS18810	COG0708	Exodeoxyribonuclease III
A8142_RS18815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8142_RS18820	COG2169	Transcriptional regulator
A8142_RS18830	COG0629	single-stranded DNA binding
A8142_RS18840	COG0012	GTP binding
A8142_RS18845	COG0243	molybdopterin cofactor binding
A8142_RS18850	COG4481	Protein conserved in bacteria
A8142_RS18855	COG3949	Membrane
A8142_RS18870	COG1475	DNA binding
A8142_RS18875	COG1192	Involved in chromosome partitioning
A8142_RS18900	COG1847	R3H domain protein
A8142_RS18905	COG0706	membrane insertase activity
A8142_RS18925	COG0592	DNA-directed DNA polymerase activity
A8142_RS18930	COG2501	S4 domain
A8142_RS18945	COG0187	DNA topoisomerase II activity
A8142_RS18950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner