locus-tag class description H1Q60_RS00010 ENOG4105E0X reductase H1Q60_RS00015 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H1Q60_RS00025 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) H1Q60_RS00030 ENOG41090WU lipolytic protein G-D-S-L family H1Q60_RS00035 ENOG4108KF3 Electron transport protein SCO1 SenC H1Q60_RS00045 ENOG4105C7B Threonine dehydratase H1Q60_RS00055 ENOG4108UT2 hemolysin iii H1Q60_RS00065 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H1Q60_RS00070 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H1Q60_RS00080 ENOG4107YX5 Pfam:DUF548 H1Q60_RS00085 ENOG4108Y6J UPF0403 protein H1Q60_RS00090 ENOG4105C01 Dihydroxy-acid dehydratase H1Q60_RS00105 ENOG4108V06 Glutathione peroxidase H1Q60_RS00110 ENOG4105CVG Homoserine O-transsuccinylase H1Q60_RS00155 ENOG41081VK Ribonuclease H1Q60_RS00180 ENOG410890F Dynamin family H1Q60_RS00205 ENOG4105C2W permease H1Q60_RS00210 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) H1Q60_RS00215 ENOG4105CTD carboxy-peptidase H1Q60_RS00220 ENOG4105DVT helicase H1Q60_RS00235 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H1Q60_RS00245 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) H1Q60_RS00250 ENOG4108UKS UPF0398 protein H1Q60_RS00265 ENOG4107X2U Inherit from COG: Exonuclease-like protein H1Q60_RS00270 ENOG4108I5C dEAD DEAH box helicase H1Q60_RS00315 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) H1Q60_RS00320 ENOG4105BZ4 penicillin-binding protein H1Q60_RS00330 ENOG4105CSM endonuclease III H1Q60_RS00340 ENOG4105C5S asparaginyl-tRNA synthetase H1Q60_RS00345 ENOG4105CHM Aminotransferase H1Q60_RS00355 ENOG4105YAC H1Q60_RS00360 ENOG4105DVT helicase H1Q60_RS00365 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H1Q60_RS00375 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H1Q60_RS00385 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate H1Q60_RS00390 ENOG4105CPK Glycosyl transferase (Group 1 H1Q60_RS00395 ENOG4105FJR Lmbe family H1Q60_RS00400 ENOG4108Z5K methylglyoxal synthase H1Q60_RS00405 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H1Q60_RS00410 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase H1Q60_RS00415 ENOG4108JYZ YitT family H1Q60_RS00420 ENOG4105F0F Oxalate decarboxylase H1Q60_RS00440 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) H1Q60_RS00460 ENOG41068YB TPR repeat-containing protein H1Q60_RS00465 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase H1Q60_RS00475 ENOG4105CIH Imidazole acetol-phosphate transaminase H1Q60_RS00485 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H1Q60_RS00490 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase H1Q60_RS00495 ENOG4105DK0 Indole-3-glycerol phosphate synthase H1Q60_RS00505 ENOG4105CRQ synthase (Component I) H1Q60_RS00510 ENOG4105KHN chorismate mutase H1Q60_RS00520 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H1Q60_RS00525 ENOG4105BZU Histidine kinase H1Q60_RS00530 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H1Q60_RS00535 ENOG4105EAH synthase H1Q60_RS00540 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H1Q60_RS00545 ENOG4105XXQ heptaprenyl diphosphate synthase component I H1Q60_RS00550 ENOG4105WP2 Tryptophan RNA-binding attenuator protein H1Q60_RS00555 ENOG4105EUJ GTP cyclohydrolase i H1Q60_RS00560 ENOG4105K70 DNA-binding protein H1Q60_RS00565 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) H1Q60_RS00580 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H1Q60_RS00585 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H1Q60_RS00605 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H1Q60_RS00610 ENOG4105CAT Cytidine monophosphate kinase H1Q60_RS00625 ENOG4105MSI germination protein ypeb H1Q60_RS00635 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) H1Q60_RS00640 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase H1Q60_RS00655 ENOG4107RGJ metallophosphoesterase H1Q60_RS00670 ENOG4105I7S Abortive infection protein H1Q60_RS00675 ENOG4105C9U ATP-dependent DNA helicase RecQ H1Q60_RS00680 ENOG4105T7X H1Q60_RS00690 ENOG4108SAX Membrane H1Q60_RS00695 ENOG4108JQ1 Dehydrogenase H1Q60_RS00710 ENOG4105BZU Histidine kinase H1Q60_RS00715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS00720 ENOG4105CRE cytochrome C H1Q60_RS00725 ENOG4107TWT Cytochrome c biogenesis protein H1Q60_RS00735 ENOG4105FE9 pseudouridine synthase H1Q60_RS00745 ENOG4108JIC nucleoside recognition domain protein H1Q60_RS00750 ENOG4105DZ1 carboxypeptidase H1Q60_RS00760 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) H1Q60_RS00765 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) H1Q60_RS00785 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H1Q60_RS00790 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H1Q60_RS00795 ENOG4108R6K riboflavin synthase, subunit alpha H1Q60_RS00820 ENOG4107ZE5 PPIases accelerate the folding of proteins H1Q60_RS00825 ENOG4105PTM secreted protein H1Q60_RS00830 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) H1Q60_RS00840 ENOG4105G6R Stage v sporulation protein ae H1Q60_RS00850 ENOG4105CZ3 stage V sporulation protein ad H1Q60_RS00855 ENOG41090VF Stage v sporulation protein ac H1Q60_RS00870 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS00875 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) H1Q60_RS00880 ENOG41082AN stage II sporulation protein H1Q60_RS00885 ENOG4105DZ1 carboxypeptidase H1Q60_RS00890 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) H1Q60_RS00895 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) H1Q60_RS00900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Q60_RS00910 ENOG4105I3K Ferric uptake regulator, Fur family H1Q60_RS00915 ENOG4105MZ9 stage II sporulation protein m H1Q60_RS00935 ENOG4105DFD Na H antiporter H1Q60_RS00940 ENOG4108IJ0 Aspartate ammonia-lyase H1Q60_RS00945 ENOG4105HDK L-asparaginase H1Q60_RS00950 ENOG4108IMY Transcriptional regulator H1Q60_RS00960 ENOG4108YZ4 nudix hydrolase H1Q60_RS00970 ENOG4105CPC Aldo Keto reductase H1Q60_RS00990 ENOG4106HZJ H1Q60_RS00995 ENOG4105RHY Pfam:UPF0157 H1Q60_RS01000 ENOG4105KAC Antibiotic biosynthesis monooxygenase H1Q60_RS01005 ENOG4108XET gCN5-related N-acetyltransferase H1Q60_RS01010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H1Q60_RS01025 ENOG4105C02 permease H1Q60_RS01035 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase H1Q60_RS01040 ENOG4105CS9 pantothenic acid kinase H1Q60_RS01050 ENOG4108IXY short-chain dehydrogenase reductase H1Q60_RS01055 ENOG41069FQ Metallo-beta-lactamase superfamily H1Q60_RS01060 ENOG4105II7 pyrroline-5-carboxylate reductase H1Q60_RS01065 ENOG4108KQ6 Enoyl-CoA hydratase H1Q60_RS01070 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase H1Q60_RS01075 ENOG4106A3M Cytochrome p-450 H1Q60_RS01090 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS01100 ENOG4105CHR reductase H1Q60_RS01105 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS01120 ENOG4107QKG PfaD family H1Q60_RS01125 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H1Q60_RS01135 ENOG4108K70 Transcriptional regulator H1Q60_RS01145 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Q60_RS01155 ENOG410861F 50S ribosomal protein L33 H1Q60_RS01160 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H1Q60_RS01165 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H1Q60_RS01170 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H1Q60_RS01175 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H1Q60_RS01185 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) H1Q60_RS01190 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H1Q60_RS01195 ENOG4108HNZ carboxyl transferase H1Q60_RS01200 ENOG4108ZVT methylmalonyl-coA epimerase H1Q60_RS01210 ENOG4108VZI ErfK ybiS ycfS ynhG family protein H1Q60_RS01215 ENOG4108QEG Membrane H1Q60_RS01220 ENOG4105CDA abc transporter atp-binding protein H1Q60_RS01225 ENOG4105E5Q amino acid AbC transporter H1Q60_RS01230 ENOG4108HW3 (ABC) transporter H1Q60_RS01235 ENOG4108Y6J UPF0403 protein H1Q60_RS01240 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) H1Q60_RS01245 ENOG4105C7S Dehydrogenase H1Q60_RS01250 ENOG4105CPP Dehydrogenase, E1 component H1Q60_RS01265 ENOG4105CKM Branched-chain carboxylic acid kinase H1Q60_RS01270 ENOG4107RDP Dehydrogenase H1Q60_RS01280 ENOG4108JUB Transcriptional regulator H1Q60_RS01285 ENOG4106CCJ Protein of unknown function (DUF2627) H1Q60_RS01290 ENOG4105CR4 methylisocitrate lyase H1Q60_RS01295 ENOG4105DXD 2-methylcitrate dehydratase H1Q60_RS01305 ENOG4105C1G acyl-Coa dehydrogenase H1Q60_RS01310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H1Q60_RS01320 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H1Q60_RS01325 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H1Q60_RS01350 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H1Q60_RS01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H1Q60_RS01370 ENOG4107QQR Sporulation H1Q60_RS01375 ENOG4105S1Z Stage IV sporulation protein B H1Q60_RS01380 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H1Q60_RS01385 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) H1Q60_RS01390 ENOG4105DX0 Hemolysin A H1Q60_RS01395 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H1Q60_RS01400 ENOG4105CTB Polyprenyl synthetase H1Q60_RS01405 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H1Q60_RS01410 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) H1Q60_RS01415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H1Q60_RS01420 ENOG4105M7K Involved in the transcription termination process (By similarity) H1Q60_RS01425 ENOG4108ZSR alkaline shock protein H1Q60_RS01430 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H1Q60_RS01450 ENOG410644B Stage III sporulation protein af H1Q60_RS01460 ENOG4105KQ4 Stage iii sporulation protein ad H1Q60_RS01465 ENOG4108CQH stage III sporulation protein AC H1Q60_RS01470 ENOG4105KR5 Stage iii sporulation protein H1Q60_RS01475 ENOG4105CD2 stage iii sporulation protein aa H1Q60_RS01485 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H1Q60_RS01490 ENOG4105DC7 peptidase M24 H1Q60_RS01500 ENOG4105CBJ Metal-dependent enzyme H1Q60_RS01520 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) H1Q60_RS01525 ENOG4105WZW rhodanese family H1Q60_RS01530 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H1Q60_RS01540 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H1Q60_RS01545 ENOG4105C0D helicase H1Q60_RS01560 ENOG4108IMY Transcriptional regulator H1Q60_RS01570 ENOG4105VFR signal peptidase H1Q60_RS01630 ENOG4105C37 (CBS) domain H1Q60_RS01655 ENOG4105C5X domain protein H1Q60_RS01700 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H1Q60_RS01715 ENOG41068DG YceG-like family H1Q60_RS01720 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H1Q60_RS01725 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H1Q60_RS01730 ENOG4105E2Z phosphate ABC transporter (Permease H1Q60_RS01735 ENOG4105C8U phosphate abc transporter H1Q60_RS01740 ENOG4105CVA phosphate H1Q60_RS01745 ENOG4107RF6 penicillin-binding protein H1Q60_RS01755 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H1Q60_RS01760 ENOG4105SXS Protein of unknown function (DUF456) H1Q60_RS01775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) H1Q60_RS01780 ENOG41063Y9 H1Q60_RS01785 ENOG4108U5J '-nucleotidase H1Q60_RS01790 ENOG4105N80 Ferric uptake regulator, Fur family H1Q60_RS01795 ENOG4108JYZ YitT family H1Q60_RS01800 ENOG41069ZM Protein of unknown function (DUF2624) H1Q60_RS01805 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) H1Q60_RS01820 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) H1Q60_RS01825 ENOG4105EGD dinuclear metal center protein, YbgI family H1Q60_RS01840 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS01845 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H1Q60_RS01850 ENOG4108UPT UPF0178 protein H1Q60_RS01855 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) H1Q60_RS01865 ENOG4105C38 Glycyl-tRNA synthetase beta subunit H1Q60_RS01870 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit H1Q60_RS01875 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) H1Q60_RS01885 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H1Q60_RS01890 ENOG4105KG3 cytidine deaminase H1Q60_RS01895 ENOG4107YR5 Diacylglycerol kinase H1Q60_RS01900 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H1Q60_RS01905 ENOG4105CTJ Metal Dependent Phosphohydrolase H1Q60_RS01910 ENOG4105C9A Phoh family H1Q60_RS01915 ENOG4105EI1 sporulation protein yqfd H1Q60_RS01920 ENOG41068P3 sporulation protein YqfC H1Q60_RS01930 ENOG4105DI5 UPF0365 protein H1Q60_RS01935 ENOG4105F7J membrane-bound serine protease H1Q60_RS01940 ENOG4105KTH gatB Yqey H1Q60_RS01955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H1Q60_RS01960 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H1Q60_RS01965 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H1Q60_RS01970 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H1Q60_RS01975 ENOG4105CFG Acts as a chaperone (By similarity) H1Q60_RS01980 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H1Q60_RS01985 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) H1Q60_RS01990 ENOG4105CSA Coproporphyrinogen iii oxidase H1Q60_RS01995 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H1Q60_RS02005 ENOG4108ZRV stage ii sporulation protein p H1Q60_RS02010 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) H1Q60_RS02015 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) H1Q60_RS02020 ENOG4105TQK DNA polymerase iii, delta' subunit H1Q60_RS02035 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 H1Q60_RS02040 ENOG4108UK2 deaminase H1Q60_RS02045 ENOG4105KQC Competence protein H1Q60_RS02055 ENOG4108D32 Methyltransferase H1Q60_RS02065 ENOG4108WF2 Metal Dependent Phosphohydrolase H1Q60_RS02070 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H1Q60_RS02075 ENOG410812S Rna-binding protein H1Q60_RS02080 ENOG4105E2X shikimate dehydrogenase H1Q60_RS02085 ENOG4105CQW ribosome biogenesis GTPase YqeH H1Q60_RS02090 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase H1Q60_RS02110 ENOG41080BT SNARE associated Golgi H1Q60_RS02125 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS02140 ENOG4106BHF H1Q60_RS02165 ENOG4107V2S Transcriptional regulator H1Q60_RS02180 ENOG4108SWU Histidine kinase H1Q60_RS02185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H1Q60_RS02190 ENOG4105DHF Membrane H1Q60_RS02195 ENOG4108UYN gCN5-related N-acetyltransferase H1Q60_RS02200 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H1Q60_RS02265 ENOG4108U7W acetyltransferase H1Q60_RS02280 ENOG4108HCJ Hydrolase H1Q60_RS02285 ENOG4108HCJ Hydrolase H1Q60_RS02295 ENOG4105DG6 mannose-6-phosphate isomerase H1Q60_RS02300 ENOG4105DM4 PTS System H1Q60_RS02315 ENOG4108Z66 YbaK ebsC protein H1Q60_RS02320 ENOG4107RSM transcriptional regulator H1Q60_RS02325 ENOG4105D94 Major Facilitator Superfamily H1Q60_RS02330 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H1Q60_RS02335 ENOG41082JN Transcriptional regulator H1Q60_RS02355 ENOG4105TMB Formate nitrite transporter H1Q60_RS02360 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) H1Q60_RS02365 ENOG4108JB9 formate dehydrogenase H1Q60_RS02380 ENOG4105C28 cystathionine H1Q60_RS02410 ENOG4107XRG penicillin-binding protein H1Q60_RS02415 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H1Q60_RS02425 ENOG4105CFP Peptidase U32 H1Q60_RS02430 ENOG4105XYU peptidase (U32 family) H1Q60_RS02440 ENOG4105HHA aminodeoxychorismate lyase H1Q60_RS02450 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H1Q60_RS02455 ENOG4105VBH UPF0297 protein H1Q60_RS02460 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H1Q60_RS02465 ENOG4105C02 permease H1Q60_RS02470 ENOG4105CDA abc transporter atp-binding protein H1Q60_RS02475 ENOG4105CT1 (ABC) transporter H1Q60_RS02480 ENOG4105EAD ABC transporter H1Q60_RS02485 ENOG4105DRP amino acid AbC transporter H1Q60_RS02495 ENOG41060CR H1Q60_RS02505 ENOG4105C7H Helicase, RecD TraA family H1Q60_RS02515 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H1Q60_RS02520 ENOG4105C3J Cysteine desulfurase H1Q60_RS02530 ENOG4105D1H recombination factor protein RarA H1Q60_RS02535 ENOG4105CUZ uba thif-type nad fad binding protein H1Q60_RS02545 ENOG4105C9M aspartyl-trna synthetase H1Q60_RS02550 ENOG4105CUT histidyl-tRNA synthetase H1Q60_RS02560 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H1Q60_RS02565 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H1Q60_RS02570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H1Q60_RS02580 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H1Q60_RS02585 ENOG41067VP Protein of unknown function (DUF1049) H1Q60_RS02590 ENOG4105NCW Trka-c domain protein H1Q60_RS02595 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H1Q60_RS02605 ENOG4105CKP Polysaccharide Biosynthesis Protein H1Q60_RS02610 ENOG4108QG2 Membrane H1Q60_RS02615 ENOG4105NAP H1Q60_RS02620 ENOG4105VIE preprotein translocase, subunit YajC H1Q60_RS02625 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H1Q60_RS02630 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H1Q60_RS02635 ENOG41061AI Protein of unknown function (DUF2905) H1Q60_RS02640 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H1Q60_RS02645 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H1Q60_RS02660 ENOG4106678 morphogenetic protein associated with SpoVID H1Q60_RS02665 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) H1Q60_RS02670 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H1Q60_RS02675 ENOG4108IYU L-aspartate oxidase H1Q60_RS02690 ENOG4105CQC Prephenate dehydratase H1Q60_RS02700 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H1Q60_RS02710 ENOG4105K46 50S ribosomal protein l27 H1Q60_RS02715 ENOG4105X36 (ribosomal) protein H1Q60_RS02720 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H1Q60_RS02735 ENOG4107QMS site-determining protein H1Q60_RS02740 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) H1Q60_RS02745 ENOG4105YHC Rod shape-determining protein MreD H1Q60_RS02755 ENOG4105DFF Rod shape-determining protein mreb H1Q60_RS02760 ENOG4105W5Q DNA repair protein (RadC H1Q60_RS02765 ENOG4108Z03 MAF-like protein H1Q60_RS02775 ENOG4106A3R peptidase H1Q60_RS02780 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H1Q60_RS02785 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H1Q60_RS02795 ENOG4106AR7 Spore coat protein H1Q60_RS02800 ENOG41068KH stage VI sporulation protein D H1Q60_RS02805 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H1Q60_RS02810 ENOG4105D52 delta-aminolevulinic acid dehydratase H1Q60_RS02820 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H1Q60_RS02830 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H1Q60_RS02840 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) H1Q60_RS02845 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H1Q60_RS02850 ENOG4108IUQ atp-dependent protease H1Q60_RS02855 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H1Q60_RS02860 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H1Q60_RS02870 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H1Q60_RS02875 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) H1Q60_RS02880 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H1Q60_RS02890 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H1Q60_RS02895 ENOG4108ZP8 Acetolactate synthase small subunit H1Q60_RS02900 ENOG4105C7K acetolactate synthase H1Q60_RS02930 ENOG4107SCJ type I restriction enzyme EcoKI subunit R H1Q60_RS02955 ENOG4105M59 Phosphodiesterase, mj0936 family H1Q60_RS02960 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H1Q60_RS02965 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) H1Q60_RS02970 ENOG4108XJQ germination protein H1Q60_RS02975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H1Q60_RS02985 ENOG4105PFC Transcriptional regulator H1Q60_RS02995 ENOG4105E33 succinate dehydrogenase H1Q60_RS03005 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit H1Q60_RS03015 ENOG4105CFH Aspartokinase H1Q60_RS03020 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H1Q60_RS03025 ENOG4105K63 Thioredoxin H1Q60_RS03030 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) H1Q60_RS03035 ENOG4105C10 Electron transfer flavoprotein H1Q60_RS03040 ENOG4105BZJ Electron transfer flavoprotein H1Q60_RS03045 ENOG41060WC Enoyl-CoA hydratase H1Q60_RS03050 ENOG4107Z3H Transcriptional regulator, TetR family H1Q60_RS03055 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS03060 ENOG4108YV3 Protein of unknown function (DUF2711) H1Q60_RS03070 ENOG4105C98 muts2 protein H1Q60_RS03075 ENOG4105DCG PHP domain protein H1Q60_RS03090 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H1Q60_RS03095 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) H1Q60_RS03100 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H1Q60_RS03105 ENOG4108RWN rrna methyltransferase H1Q60_RS03110 ENOG41067MF small acid-soluble spore protein H1Q60_RS03120 ENOG4105CQB FAD linked oxidase domain protein H1Q60_RS03125 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H1Q60_RS03135 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) H1Q60_RS03140 ENOG4105DRS transport system, permease H1Q60_RS03155 ENOG4108MDK Dehydrogenase H1Q60_RS03165 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H1Q60_RS03170 ENOG4105EF1 ribulokinase H1Q60_RS03180 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase H1Q60_RS03185 ENOG4105CN9 Peptidase m42 family protein H1Q60_RS03195 ENOG410696E Membrane H1Q60_RS03200 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H1Q60_RS03205 ENOG4105VJV 50s ribosomal protein L35 H1Q60_RS03210 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H1Q60_RS03215 ENOG41067MG lrgb family H1Q60_RS03225 ENOG4105DY9 regulatoR H1Q60_RS03230 ENOG4108HRK Histidine kinase H1Q60_RS03240 ENOG4105C22 threonyL-tRNA synthetase H1Q60_RS03245 ENOG4108TDW sporulation protein YtxC H1Q60_RS03270 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) H1Q60_RS03275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H1Q60_RS03280 ENOG4105KVH Transcriptional regulator H1Q60_RS03285 ENOG4105F27 Major Facilitator H1Q60_RS03290 ENOG4105CV8 reductase H1Q60_RS03295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H1Q60_RS03305 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) H1Q60_RS03310 ENOG4105C2M dna polymerase I H1Q60_RS03315 ENOG4105BZU Histidine kinase H1Q60_RS03320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H1Q60_RS03330 ENOG4108HMX isocitrate dehydrogenase (NADP) H1Q60_RS03335 ENOG4105BZN citrate synthase H1Q60_RS03345 ENOG410780I phosphoprotein phosphatase activity H1Q60_RS03380 ENOG4105G7B Protein of unknown function (DUF2992) H1Q60_RS03390 ENOG4108REF Sporulation integral membrane protein ytvi H1Q60_RS03395 ENOG4105FS0 cytoplasmic membrane protein H1Q60_RS03400 ENOG4105CA9 Pyruvate kinase H1Q60_RS03405 ENOG4105CTQ phosphohexokinase H1Q60_RS03410 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H1Q60_RS03415 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H1Q60_RS03420 ENOG4105C6K Malic enzyme H1Q60_RS03425 ENOG4105C0B DNA polymerase III (alpha subunit) H1Q60_RS03430 ENOG4105VV2 H1Q60_RS03440 ENOG4106EVM H1Q60_RS03445 ENOG4105SFS phosphoesterase RecJ domain protein H1Q60_RS03460 ENOG4105E8R UPF0173 metal-dependent hydrolase H1Q60_RS03470 ENOG4105CH7 arginosuccinase H1Q60_RS03475 ENOG4105CDH Citrulline--aspartate ligase H1Q60_RS03480 ENOG4105EPU Molybdenum cofactor synthesis domain protein H1Q60_RS03485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H1Q60_RS03495 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H1Q60_RS03500 ENOG4105KBJ sporulation protein ytfj H1Q60_RS03510 ENOG4105VK3 rdd domain containing protein H1Q60_RS03515 ENOG4105D07 Signal peptide peptidase, SppA H1Q60_RS03520 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H1Q60_RS03525 ENOG4105EFZ amidohydrolase H1Q60_RS03530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H1Q60_RS03540 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) H1Q60_RS03565 ENOG4105U5Y Transcriptional regulator H1Q60_RS03575 ENOG4105BZU Histidine kinase H1Q60_RS03580 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H1Q60_RS03585 ENOG4105C26 Dehydrogenase H1Q60_RS03655 ENOG4108Z0Z intracellular protease Pfpi family H1Q60_RS03675 ENOG4108NGU Transcriptional regulator H1Q60_RS03690 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H1Q60_RS03700 ENOG4105F1V Acetoin utilization protein H1Q60_RS03705 ENOG4105W87 Cbs domain H1Q60_RS03710 ENOG4105DGU Histone deacetylase H1Q60_RS03715 ENOG4105ER2 Ompa motb domain protein H1Q60_RS03720 ENOG4107R0U MotA TolQ exbB proton channel H1Q60_RS03725 ENOG4105ETE Transcriptional regulator (LacI family H1Q60_RS03730 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H1Q60_RS03750 ENOG4105DFU Cell wall formation (By similarity) H1Q60_RS03760 ENOG4108VDD TRNA binding domain protein H1Q60_RS03775 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ H1Q60_RS03800 ENOG4105C6K Malic enzyme H1Q60_RS03805 ENOG4105C8F Beta-lactamase domain protein H1Q60_RS03810 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H1Q60_RS03820 ENOG4108V15 phosphotransferase enzyme family H1Q60_RS03835 ENOG4107F58 2'-5' rna ligase H1Q60_RS03840 ENOG4105C6T cysteine synthase H1Q60_RS03845 ENOG4107QSE Dipeptidase H1Q60_RS03850 ENOG4105C7N Xanthine uracil vitamin C permease H1Q60_RS03865 ENOG4105YW5 deoR family transcriptional regulator H1Q60_RS03880 ENOG4105CBX hi0933 family H1Q60_RS03885 ENOG4105C94 Transporter H1Q60_RS03925 ENOG41085GJ domain protein H1Q60_RS03930 ENOG4105C8T Leucyl-tRNA synthetase H1Q60_RS03940 ENOG4105BZU Histidine kinase H1Q60_RS03945 ENOG410605W Major Facilitator H1Q60_RS03960 ENOG4105C19 ABC transporter H1Q60_RS03965 ENOG4105EWM Histidine kinase H1Q60_RS03975 ENOG4107R34 abc transporter permease protein H1Q60_RS03980 ENOG4105C19 ABC transporter H1Q60_RS04000 ENOG4105DVE abc transporter atp-binding protein H1Q60_RS04005 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family H1Q60_RS04025 ENOG4105N5T Radical SAM Protein H1Q60_RS04040 ENOG4107VXM glycerophosphoryl diester phosphodiesterase H1Q60_RS04050 ENOG4105E8V Alpha Beta Hydrolase Fold protein H1Q60_RS04055 ENOG4108Z0R Transferase H1Q60_RS04060 ENOG4105C85 amino acid H1Q60_RS04065 ENOG4105CAQ asparagine synthetase H1Q60_RS04070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H1Q60_RS04075 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H1Q60_RS04090 ENOG4105D2X ABC transporter substrate-binding protein H1Q60_RS04100 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component H1Q60_RS04115 ENOG4108RMU ferritin dps family protein H1Q60_RS04130 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) H1Q60_RS04135 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H1Q60_RS04140 ENOG4108V2W Carbonate dehydratase H1Q60_RS04145 ENOG4105NRA 50s ribosomal protein l31 type b H1Q60_RS04165 ENOG4105CC5 ABC transporter H1Q60_RS04170 ENOG4105CC5 ABC transporter H1Q60_RS04175 ENOG4105DIK (ABC) transporter H1Q60_RS04180 ENOG4105DSE periplasmic solute binding protein H1Q60_RS04185 ENOG4105DTQ mandelate racemase muconate lactonizing H1Q60_RS04190 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS04195 ENOG4108IPT Naphthoate synthase H1Q60_RS04200 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) H1Q60_RS04205 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H1Q60_RS04210 ENOG4105E4F Isochorismate synthase H1Q60_RS04345 ENOG4105N67 Proton-coupled thiamine transporter YuaJ H1Q60_RS04350 ENOG4105DZ6 Band 7 protein H1Q60_RS04360 ENOG4106DF1 H1Q60_RS04365 ENOG4108VNY MOSC domain protein H1Q60_RS04370 ENOG4108JB8 alcohol dehydrogenase H1Q60_RS04380 ENOG4105TRT Transcriptional regulator H1Q60_RS04395 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H1Q60_RS04400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H1Q60_RS04450 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Q60_RS04460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H1Q60_RS04470 ENOG4105EE0 oxidoreductase H1Q60_RS04475 ENOG4108Z0Z intracellular protease Pfpi family H1Q60_RS04480 ENOG4105C8Q Methyl-accepting chemotaxis H1Q60_RS04485 ENOG4105C8Q Methyl-accepting chemotaxis H1Q60_RS04490 ENOG4105C8Q Methyl-accepting chemotaxis H1Q60_RS04495 ENOG4105C8Q Methyl-accepting chemotaxis H1Q60_RS04510 ENOG4105EA8 2-Nitropropane dioxygenase H1Q60_RS04515 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme H1Q60_RS04525 ENOG4105C37 (CBS) domain H1Q60_RS04540 ENOG4107PBV potassium channel H1Q60_RS04545 ENOG4107PBV potassium channel H1Q60_RS04560 ENOG4107QYV phosphohexose isomerase H1Q60_RS04570 ENOG4105CHJ isochorismatase hydrolase H1Q60_RS04585 ENOG4105WG9 Conserved Protein H1Q60_RS04600 ENOG4105CHM Aminotransferase H1Q60_RS04605 ENOG4108ZB6 transcriptional regulator AsnC family H1Q60_RS04610 ENOG4108MUZ hydrolase H1Q60_RS04620 ENOG4105C87 Aminotransferase class I and II H1Q60_RS04625 ENOG4108HGU Histidine kinase H1Q60_RS04630 ENOG4105Y38 Kinase-associated protein B H1Q60_RS04645 ENOG4105BZ4 penicillin-binding protein H1Q60_RS04650 ENOG4105KIR Thiol-disulfide oxidoreductase dcc H1Q60_RS04665 ENOG4108MRH transcriptional regulatory protein H1Q60_RS04670 ENOG4105DIH basic membrane H1Q60_RS04675 ENOG4108JQ9 ABC transporter H1Q60_RS04680 ENOG4105UIB (ABC) transporter H1Q60_RS04695 ENOG4105D65 subunit l H1Q60_RS04700 ENOG4105HC0 Na H antiporter H1Q60_RS04705 ENOG4108ZE9 Monovalent cation H antiporter subunit C H1Q60_RS04710 ENOG4108JPZ Monovalent cation H antiporter subunit D H1Q60_RS04715 ENOG4105SC1 monovalent cation H antiporter subunit E H1Q60_RS04725 ENOG4105KJM monovalent cation h antiporter subunit g H1Q60_RS04730 ENOG4105KA0 thioesterase Superfamily protein H1Q60_RS04740 ENOG4105BZU Histidine kinase H1Q60_RS04765 ENOG4105D58 Diguanylate phosphodiesterase H1Q60_RS04770 ENOG4105DAP Nicotinate phosphoribosyltransferase H1Q60_RS04795 ENOG4105C02 permease H1Q60_RS04810 ENOG410904N short-chain dehydrogenase reductase H1Q60_RS04845 ENOG4108K8K Transcriptional regulator H1Q60_RS04850 ENOG4105DCF alanine dehydrogenase H1Q60_RS04860 ENOG4105WQT MbtH domain protein H1Q60_RS04865 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS04870 ENOG4105WQI isochorismatase H1Q60_RS04875 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H1Q60_RS04880 ENOG4105E4F Isochorismate synthase H1Q60_RS04885 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H1Q60_RS04890 ENOG4105NIV Esterase H1Q60_RS04910 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) H1Q60_RS04920 ENOG41069ER domain protein H1Q60_RS04935 ENOG4105CEP NADH dehydrogenase H1Q60_RS04950 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) H1Q60_RS04965 ENOG4105CJ1 ABC, transporter H1Q60_RS04985 ENOG4105D9U N-acetyltransferase H1Q60_RS04990 ENOG4108VHC Short-chain dehydrogenase reductase Sdr H1Q60_RS04995 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H1Q60_RS05000 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H1Q60_RS05010 ENOG4105ZKE UPF0349 protein H1Q60_RS05025 ENOG41083MR nifu domain-containing protein H1Q60_RS05030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein H1Q60_RS05035 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) H1Q60_RS05040 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) H1Q60_RS05045 ENOG4105D6E homoserine dehydrogenase H1Q60_RS05055 ENOG4108W5N phosphatidylglycerophosphatase a H1Q60_RS05060 ENOG4105D4U had-superfamily hydrolase, subfamily iia H1Q60_RS05070 ENOG4105MMD transcriptional regulator H1Q60_RS05075 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H1Q60_RS05080 ENOG4105FAA peptidase M23 H1Q60_RS05085 ENOG4108YTE sporulation protein YunB H1Q60_RS05090 ENOG4107R8B 5'-nucleotidase H1Q60_RS05100 ENOG4105I3N Conserved Protein H1Q60_RS05110 ENOG4105CD3 dihydroorotase H1Q60_RS05115 ENOG4105G9B Transcriptional regulator H1Q60_RS05135 ENOG4105C5R Aminotransferase H1Q60_RS05145 ENOG4108K8S endonuclease I H1Q60_RS05150 ENOG4108IJ9 (ABC) transporter H1Q60_RS05155 ENOG4105FDP GntR family transcriptional regulator H1Q60_RS05160 ENOG4108KPW sugar kinase H1Q60_RS05165 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component H1Q60_RS05170 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component H1Q60_RS05175 ENOG4105XN3 extracellular solute-binding protein family 1 H1Q60_RS05180 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine H1Q60_RS05185 ENOG4108Z6Z Transcriptional regulator H1Q60_RS05210 ENOG4105PKS Excinuclease abc c subunit domain protein H1Q60_RS05215 ENOG4107VFR oxidoreductase H1Q60_RS05220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H1Q60_RS05230 ENOG41083Q9 chitosanase H1Q60_RS05235 ENOG4105DIW FeS assembly protein SUFB H1Q60_RS05240 ENOG4108UNV SUF system FeS assembly protein, NifU family H1Q60_RS05245 ENOG4105C9B Cysteine desulfurase H1Q60_RS05250 ENOG4105JRK feS assembly protein SufD H1Q60_RS05255 ENOG4105C3K feS assembly ATPase SufC H1Q60_RS05270 ENOG4105D01 (LipO)protein H1Q60_RS05275 ENOG4108UMI ABC transporter, permease H1Q60_RS05280 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H1Q60_RS05305 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H1Q60_RS05310 ENOG41080E8 Transcriptional regulator, Spx MgsR family H1Q60_RS05315 ENOG4105C1G acyl-Coa dehydrogenase H1Q60_RS05320 ENOG4105CHU acetyl-coa acetyltransferase H1Q60_RS05350 ENOG41067TZ transcriptional regulator, MarR family H1Q60_RS05355 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Q60_RS05375 ENOG4105E0A ABC, transporter H1Q60_RS05390 ENOG4105E1F short-chain dehydrogenase reductase H1Q60_RS05395 ENOG4105HUF DNA protection during starvation protein H1Q60_RS05400 ENOG4105C0H protease H1Q60_RS05410 ENOG4105F3H Histidine kinase H1Q60_RS05420 ENOG41067SE Tetr family transcriptional regulator H1Q60_RS05425 ENOG4105C9Q fumarate hydratase class II H1Q60_RS05450 ENOG4105WH1 Two component transcriptional regulator luxr family H1Q60_RS05455 ENOG4105ENE Histidine kinase H1Q60_RS05470 ENOG41087YS Phage shock protein A H1Q60_RS05485 ENOG4108WBT adenosyltransferase H1Q60_RS05490 ENOG4105E0A ABC, transporter H1Q60_RS05495 ENOG4105EHG Permease protein H1Q60_RS05500 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H1Q60_RS05505 ENOG4105EWI Short-chain dehydrogenase reductase Sdr H1Q60_RS05510 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein H1Q60_RS05520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H1Q60_RS05530 ENOG4106DF4 Sigma-70, region 4 H1Q60_RS05540 ENOG4105F0F Oxalate decarboxylase H1Q60_RS05550 ENOG4105E0A ABC, transporter H1Q60_RS05555 ENOG4105EHG Permease protein H1Q60_RS05560 ENOG4105DQ5 transport system permease protein H1Q60_RS05570 ENOG4105JQZ Methyltransferase H1Q60_RS05575 ENOG4105D5Q Arginine ornithine antiporter H1Q60_RS05585 ENOG4107K5X Membrane-bound metal-dependent hydrolase H1Q60_RS05595 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family H1Q60_RS05600 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H1Q60_RS05605 ENOG4105E0C molybdate abc transporter H1Q60_RS05610 ENOG4105WH1 Two component transcriptional regulator luxr family H1Q60_RS05620 ENOG4105CJ1 ABC, transporter H1Q60_RS05630 ENOG4108KYE ABC-2 type transporter H1Q60_RS05645 ENOG4105EEQ Na H antiporter H1Q60_RS05650 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) H1Q60_RS05655 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H1Q60_RS05660 ENOG4105EEM helicase H1Q60_RS05665 ENOG4105EN6 Membrane H1Q60_RS05680 ENOG4107ZQN disulfide bond H1Q60_RS05685 ENOG4105C59 p-type ATPase H1Q60_RS05690 ENOG4105C59 p-type ATPase H1Q60_RS05695 ENOG410681U heavy metal transport detoxification protein H1Q60_RS05700 ENOG4105VPX protein, conserved in bacteria H1Q60_RS05705 ENOG4105D9R oxidoreductase H1Q60_RS05710 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H1Q60_RS05725 ENOG4105DEN Luciferase family H1Q60_RS05730 ENOG4105CDA abc transporter atp-binding protein H1Q60_RS05755 ENOG4108XSB acetyltransferase, (GNAT) family H1Q60_RS05760 ENOG4108KSA LysR family transcriptional regulator H1Q60_RS05765 ENOG4105EWI Short-chain dehydrogenase reductase Sdr H1Q60_RS05770 ENOG41067XF inhibitor H1Q60_RS05775 ENOG41067XF inhibitor H1Q60_RS05785 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H1Q60_RS05790 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H1Q60_RS05800 ENOG4105XZU Preprotein translocase, subunit SecG H1Q60_RS05820 ENOG4105KVH Transcriptional regulator H1Q60_RS05845 ENOG4105DA5 (ABC) transporter H1Q60_RS05850 ENOG4105R40 Glycine betaine carnitine choline H1Q60_RS05855 ENOG4108HQR Glycine betaine H1Q60_RS05860 ENOG4105E90 ABC transporter H1Q60_RS05865 ENOG4108IJ8 ABC transporter H1Q60_RS05870 ENOG4107HG4 Transcriptional regulator H1Q60_RS05875 ENOG4105R40 Glycine betaine carnitine choline H1Q60_RS05880 ENOG4108HQR Glycine betaine H1Q60_RS05885 ENOG4105E90 ABC transporter H1Q60_RS05890 ENOG4108IJ8 ABC transporter H1Q60_RS05895 ENOG4107HG4 Transcriptional regulator H1Q60_RS05900 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H1Q60_RS05910 ENOG4105T65 Membrane-associated protein H1Q60_RS05915 ENOG4108W0I acetyltransferase H1Q60_RS05920 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H1Q60_RS05925 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H1Q60_RS05930 ENOG4105CP7 Triose-phosphate isomerase H1Q60_RS05935 ENOG4105BZA Phosphoglycerate kinase H1Q60_RS05940 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H1Q60_RS05955 ENOG4105CMD Transcriptional regulator, GntR family H1Q60_RS05965 ENOG4105DEN Luciferase family H1Q60_RS05975 ENOG4105GZI Transcriptional regulator H1Q60_RS05980 ENOG4107RT3 EamA-like transporter family H1Q60_RS05990 ENOG4106KNT transcriptional regulator H1Q60_RS05995 ENOG4105CMG Carbohydrate kinase H1Q60_RS06010 ENOG4107QR9 Iron-sulfur cluster binding protein H1Q60_RS06015 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H1Q60_RS06025 ENOG4105JXH GntR family transcriptional regulator H1Q60_RS06030 ENOG4105DAA L-lactate H1Q60_RS06035 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS06045 ENOG4108ZPC Polysaccharide pyruvyl transferase H1Q60_RS06050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H1Q60_RS06055 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family H1Q60_RS06060 ENOG4105D3Q Sugar transferase H1Q60_RS06070 ENOG4105K64 Glycosyl transferase, family 2 H1Q60_RS06080 ENOG4107QRS glycosyltransferase group 2 family protein H1Q60_RS06085 ENOG41068W6 Capsular polysaccharide biosynthesis protein H1Q60_RS06090 ENOG4108KMV Glycosyl transferase (Group 1 H1Q60_RS06095 ENOG4105K64 Glycosyl transferase, family 2 H1Q60_RS06100 ENOG4108PQP glycosyl transferase group 1 H1Q60_RS06110 ENOG4108QV3 biosynthesis protein H1Q60_RS06115 ENOG4105HTX biosynthesis protein H1Q60_RS06125 ENOG4105EBR Carboxylesterase H1Q60_RS06135 ENOG4105NAE bifunctional deaminase-reductase domain protein H1Q60_RS06145 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 H1Q60_RS06150 ENOG4105PY6 Phenolic acid decarboxylase H1Q60_RS06155 ENOG4105NI3 Protein of unknown function (DUF3237) H1Q60_RS06190 ENOG4105DDN Pentapeptide repeat-containing protein H1Q60_RS06195 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Q60_RS06205 ENOG4108HKT sucrose-6-phosphate hydrolase H1Q60_RS06210 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H1Q60_RS06215 ENOG4105ETE Transcriptional regulator (LacI family H1Q60_RS06220 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H1Q60_RS06225 ENOG4107URF beta-phospho-glucomutase H1Q60_RS06230 ENOG4105CG3 alpha amylase, catalytic region H1Q60_RS06245 ENOG4105EG2 ABC transporter, permease H1Q60_RS06250 ENOG4105D56 permease protein H1Q60_RS06255 ENOG4107FKK extracellular solute-binding protein family 1 H1Q60_RS06260 ENOG4108IUK alpha amylase, catalytic H1Q60_RS06265 ENOG4105FKQ transcriptional regulator H1Q60_RS06270 ENOG4108URH decarboxylase H1Q60_RS06275 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain H1Q60_RS06280 ENOG4105CHH sulfate transporter H1Q60_RS06285 ENOG4108V2W Carbonate dehydratase H1Q60_RS06290 ENOG4105C5I Dehydrogenase H1Q60_RS06295 ENOG4105GGE ribonuclease H1Q60_RS06300 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H1Q60_RS06305 ENOG4105KRI phosphocarrier protein (HPr H1Q60_RS06310 ENOG4105CIE May be required for sporulation (By similarity) H1Q60_RS06315 ENOG4105CHW UPF0052 protein H1Q60_RS06320 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) H1Q60_RS06325 ENOG4108Z4K mutator MutT protein H1Q60_RS06330 ENOG4105C3M thioredoxin reductase H1Q60_RS06345 ENOG4105BZU Histidine kinase H1Q60_RS06350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS06355 ENOG4105GIG H1Q60_RS06360 ENOG4105BZ1 (ABC) transporter H1Q60_RS06365 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H1Q60_RS06370 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H1Q60_RS06375 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H1Q60_RS06380 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H1Q60_RS06385 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H1Q60_RS06390 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H1Q60_RS06395 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H1Q60_RS06400 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) H1Q60_RS06410 ENOG4108S4C acetyltransferase H1Q60_RS06415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H1Q60_RS06425 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) H1Q60_RS06430 ENOG4105CE4 GlcNAc 6-P deacetylase H1Q60_RS06435 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) H1Q60_RS06445 ENOG4105J7D transcriptional regulator H1Q60_RS06450 ENOG41088CQ domain protein H1Q60_RS06455 ENOG41086DT Membrane protein of unknown function H1Q60_RS06460 ENOG41067S9 phage shock protein C, PspC H1Q60_RS06465 ENOG4108PY7 H1Q60_RS06480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H1Q60_RS06485 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H1Q60_RS06500 ENOG4105MKU Transcriptional regulator H1Q60_RS06525 ENOG4105CN1 protease H1Q60_RS06530 ENOG4108M26 parallel beta-helix repeat protein H1Q60_RS06535 ENOG4105CRP Part of the ABC transporter FtsEX involved in H1Q60_RS06540 ENOG4105CAK Cell division ATP-binding protein ftsE H1Q60_RS06560 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H1Q60_RS06565 ENOG4105MS2 ribosomal subunit Interface protein H1Q60_RS06580 ENOG4105MQ3 flagellar protein FliS H1Q60_RS06585 ENOG4107RT6 flagellar hook-associated H1Q60_RS06590 ENOG4105I03 Flagellin H1Q60_RS06595 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H1Q60_RS06600 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) H1Q60_RS06610 ENOG4105DTJ flagellar hook-associated protein H1Q60_RS06615 ENOG4105E1Q flagellar hook-associated protein H1Q60_RS06630 ENOG4105RU3 H1Q60_RS06635 ENOG41081UC Inherit from COG: Competence protein H1Q60_RS06655 ENOG4105WH1 Two component transcriptional regulator luxr family H1Q60_RS06660 ENOG4105BZU Histidine kinase H1Q60_RS06665 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H1Q60_RS06670 ENOG4108KGH TRANSCRIPTIONal H1Q60_RS06675 ENOG4105ESV Glycosyl transferase, family 4 H1Q60_RS06680 ENOG4107EF8 Glycosyl transferase (Group 1 H1Q60_RS06695 ENOG4105QZI O-Antigen Polymerase H1Q60_RS06700 ENOG4105C6Y Udp-glucose 6-dehydrogenase H1Q60_RS06705 ENOG4107RA4 Glycosyl transferase (Group 1 H1Q60_RS06710 ENOG4105PSV Polysaccharide Biosynthesis Protein H1Q60_RS06715 ENOG4105D3Q Sugar transferase H1Q60_RS06720 ENOG4108KGH TRANSCRIPTIONal H1Q60_RS06725 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H1Q60_RS06730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H1Q60_RS06735 ENOG4105EY8 ABC transporter H1Q60_RS06745 ENOG4107SJB teichoic acid biosynthesis H1Q60_RS06750 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) H1Q60_RS06755 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase H1Q60_RS06765 ENOG4107RZX Teichoic acid biosynthesis protein H1Q60_RS06780 ENOG4107RZX Teichoic acid biosynthesis protein H1Q60_RS06810 ENOG4105DG6 mannose-6-phosphate isomerase H1Q60_RS06825 ENOG4108NHD germination protein H1Q60_RS06830 ENOG4107R8N Glycosyl transferase, family 2 H1Q60_RS06835 ENOG4105C54 Major Facilitator superfamily H1Q60_RS06840 ENOG4108KGH TRANSCRIPTIONal H1Q60_RS06845 ENOG4105J7I hydrolase H1Q60_RS06850 ENOG4106UBQ H1Q60_RS06855 ENOG4105K4H Nlp p60 protein H1Q60_RS06865 ENOG4105PNM synthesis protein H1Q60_RS06875 ENOG4105N98 Capsule biosynthesis protein capB H1Q60_RS06880 ENOG4105E1K spore germination protein H1Q60_RS06895 ENOG4105ETE Transcriptional regulator (LacI family H1Q60_RS06900 ENOG4108RVA ribokinase H1Q60_RS06905 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) H1Q60_RS06910 ENOG4105C2J ABC transporter H1Q60_RS06915 ENOG4105CNN ABC, transporter H1Q60_RS06920 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H1Q60_RS06930 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein H1Q60_RS06935 ENOG4107FQX Alpha-acetolactate decarboxylase H1Q60_RS06945 ENOG4107RSM transcriptional regulator H1Q60_RS06975 ENOG4107XC4 flavin reductase domain protein, FMN-binding H1Q60_RS06985 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H1Q60_RS06995 ENOG4105CAH Chromate H1Q60_RS07000 ENOG4105FGV Chromate H1Q60_RS07010 ENOG4108WS4 fmn reductase H1Q60_RS07015 ENOG4107V2S Transcriptional regulator H1Q60_RS07020 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) H1Q60_RS07070 ENOG4108XI2 Domain of unknown function (DUF1963) H1Q60_RS07075 ENOG4105C6Y Udp-glucose 6-dehydrogenase H1Q60_RS07080 ENOG4108RB3 Capsular polysaccharide biosynthesis protein H1Q60_RS07085 ENOG4107YJ4 chain length determinant protein H1Q60_RS07090 ENOG4105HTX biosynthesis protein H1Q60_RS07100 ENOG4105KBK Zinc finger, swim domain protein H1Q60_RS07105 ENOG4105C0D helicase H1Q60_RS07110 ENOG410667J hydrolase H1Q60_RS07115 ENOG4105E98 transcriptional regulator DeoR family H1Q60_RS07120 ENOG4105Z8H single-stranded DNA-binding protein H1Q60_RS07135 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H1Q60_RS07140 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H1Q60_RS07150 ENOG4105CGA flagellar basal-body rod protein FlgG H1Q60_RS07160 ENOG4105DFF Rod shape-determining protein mreb H1Q60_RS07165 ENOG4105MT0 Sporulation transcriptional regulator spoiiid H1Q60_RS07170 ENOG4107MII Sugar-specific transcriptional regulator TrmB H1Q60_RS07175 ENOG4105CZM Major Facilitator H1Q60_RS07180 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease H1Q60_RS07185 ENOG41080V3 Major Facilitator superfamily H1Q60_RS07190 ENOG4105D3W isochorismatase H1Q60_RS07195 ENOG4105BZU Histidine kinase H1Q60_RS07205 ENOG4105CNI cell division protein FtsW H1Q60_RS07210 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H1Q60_RS07220 ENOG4105FRN stage II sporulation protein H1Q60_RS07225 ENOG4107TCE N-acetyltransferase H1Q60_RS07240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H1Q60_RS07245 ENOG4106BRK H1Q60_RS07250 ENOG4107T94 Endo-14-beta-xylanase H1Q60_RS07255 ENOG4108Z40 Transcriptional regulator H1Q60_RS07260 ENOG4105CQM Urea amidohydrolase subunit alpha H1Q60_RS07265 ENOG4105KI2 Urea amidohydrolase subunit beta H1Q60_RS07270 ENOG4108YZ9 Urea amidohydrolase subunit gamma H1Q60_RS07290 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H1Q60_RS07295 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) H1Q60_RS07320 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H1Q60_RS07330 ENOG4106778 Protein of unknown function (DUF1146) H1Q60_RS07340 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) H1Q60_RS07345 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H1Q60_RS07350 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H1Q60_RS07355 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H1Q60_RS07360 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H1Q60_RS07375 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) H1Q60_RS07385 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H1Q60_RS07390 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H1Q60_RS07395 ENOG4108UIC UPF0340 protein H1Q60_RS07400 ENOG4108YZG isomerase H1Q60_RS07405 ENOG4107WAU Protein tyrosine phosphatase H1Q60_RS07410 ENOG410815N Probably functions as a manganese efflux pump (By similarity) H1Q60_RS07415 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H1Q60_RS07425 ENOG4108ZXQ stage ii sporulation protein r H1Q60_RS07440 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H1Q60_RS07445 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H1Q60_RS07450 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H1Q60_RS07460 ENOG4107TT2 Auxin Efflux Carrier H1Q60_RS07465 ENOG4105C6K Malic enzyme H1Q60_RS07470 ENOG4107104 thymidine kinase H1Q60_RS07480 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H1Q60_RS07485 ENOG4105CBT Fructose-1,6-bisphosphatase H1Q60_RS07490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H1Q60_RS07500 ENOG4105D2N Aldolase H1Q60_RS07505 ENOG410812K response regulator receiver protein H1Q60_RS07515 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H1Q60_RS07525 ENOG4105DF6 Fe-S oxidoreductase H1Q60_RS07535 ENOG4105E5J UV damage endonuclease H1Q60_RS07545 ENOG4105BZ1 (ABC) transporter H1Q60_RS07550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H1Q60_RS07565 ENOG4105R3A Nitrate reductase H1Q60_RS07570 ENOG4108IUE nitrate reductase beta subunit H1Q60_RS07590 ENOG4107V6Q Cyclic nucleotide-binding domain H1Q60_RS07600 ENOG4105C75 arginyL-tRNA synthetase H1Q60_RS07605 ENOG410684U Domain of unknown function (DUF1934) H1Q60_RS07610 ENOG4107JM4 Tetratricopeptide repeat H1Q60_RS07620 ENOG4105CYW agmatinase H1Q60_RS07625 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) H1Q60_RS07630 ENOG4105BZ4 penicillin-binding protein H1Q60_RS07640 ENOG4108XFG YwhD family H1Q60_RS07645 ENOG4108Z4T Peptidase M50 H1Q60_RS07650 ENOG41069HH 4-oxalocrotonate tautomerase H1Q60_RS07655 ENOG41067TZ transcriptional regulator, MarR family H1Q60_RS07660 ENOG4105CUB amino acid H1Q60_RS07670 ENOG4105DCI Phosphohydrolase H1Q60_RS07680 ENOG4108VCI transcription factor, rsfa family H1Q60_RS07685 ENOG4105K7K Transcriptional regulator H1Q60_RS07695 ENOG4105CJ1 ABC, transporter H1Q60_RS07700 ENOG4108TU7 Inherit from COG: (ABC) transporter H1Q60_RS07725 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) H1Q60_RS07730 ENOG4105DUM transcriptional regulator, lysR family H1Q60_RS07735 ENOG4105HMI Membrane H1Q60_RS07740 ENOG4108IJ2 phosphate acetyltransferase H1Q60_RS07745 ENOG4107JTW chlorite dismutase H1Q60_RS07755 ENOG4105CHM Aminotransferase H1Q60_RS07785 ENOG4105FCW Major Facilitator superfamily H1Q60_RS07790 ENOG4105C2C drug resistance transporter, Bcr CflA H1Q60_RS07805 ENOG4105C26 Dehydrogenase H1Q60_RS07810 ENOG4105D82 Glutamate dehydrogenase H1Q60_RS07820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family H1Q60_RS07840 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase H1Q60_RS07845 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase H1Q60_RS07850 ENOG4105C1B dTDP-glucose 4-6-dehydratase H1Q60_RS07855 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H1Q60_RS07860 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG H1Q60_RS07865 ENOG4107TY6 Acylneuraminate cytidylyltransferase H1Q60_RS07875 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD H1Q60_RS07880 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H1Q60_RS07915 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H1Q60_RS07920 ENOG4108RJ9 Glycosyl transferase, family 2 H1Q60_RS07940 ENOG4105DWF phosphomethylpyrimidine kinase H1Q60_RS07955 ENOG4105C5Y PTS System H1Q60_RS07970 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin H1Q60_RS07975 ENOG4105DEN Luciferase family H1Q60_RS07980 ENOG4108DBC nitroreductase H1Q60_RS07990 ENOG4105I4A GCN5-related N-acetyltransferase H1Q60_RS08010 ENOG4105BZ9 Cytochrome C oxidase, subunit I H1Q60_RS08015 ENOG4105E2S oxidase) subunit II H1Q60_RS08020 ENOG4107BMA Transglycosylase associated protein H1Q60_RS08030 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) H1Q60_RS08035 ENOG4105WH5 Teichoic acid glycosylation protein H1Q60_RS08060 ENOG4107ZXU DSBA oxidoreductase H1Q60_RS08065 ENOG4105DBE peroxidase H1Q60_RS08070 ENOG410650H (LipO)protein H1Q60_RS08075 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H1Q60_RS08080 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase H1Q60_RS08085 ENOG4105CMU LysR family (Transcriptional regulator H1Q60_RS08090 ENOG4105VAW lrga family H1Q60_RS08095 ENOG41067MG lrgb family H1Q60_RS08100 ENOG4108RDQ ABC transporter H1Q60_RS08130 ENOG4107TXC Transcriptional regulator H1Q60_RS08140 ENOG4105DR4 Methyltransferase H1Q60_RS08150 ENOG4105CK1 PTS System H1Q60_RS08155 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin H1Q60_RS08160 ENOG4105X1N Glycosyl transferase family 8 H1Q60_RS08170 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H1Q60_RS08180 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) H1Q60_RS08185 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H1Q60_RS08190 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) H1Q60_RS08195 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD H1Q60_RS08200 ENOG4105CM2 brancheD-chain amino acid aminotransferase H1Q60_RS08205 ENOG4105F8D glycoside hydrolase family 4 H1Q60_RS08210 ENOG4105VCP PTS System H1Q60_RS08215 ENOG4105CK1 PTS System H1Q60_RS08220 ENOG4105VZJ PTS System H1Q60_RS08225 ENOG4105EMD TRANSCRIPTIONal H1Q60_RS08235 ENOG4105DQ5 transport system permease protein H1Q60_RS08240 ENOG4105EHG Permease protein H1Q60_RS08250 ENOG41082YX Transcriptional regulator, arsr family H1Q60_RS08255 ENOG4107R5R arsenical pump membrane protein H1Q60_RS08260 ENOG4105VZJ PTS System H1Q60_RS08265 ENOG4105VCP PTS System H1Q60_RS08270 ENOG4105CK1 PTS System H1Q60_RS08275 ENOG4105CS2 ec 3.2.1.21 H1Q60_RS08280 ENOG4105EVU fructokinase H1Q60_RS08285 ENOG4105DG6 mannose-6-phosphate isomerase H1Q60_RS08295 ENOG4105CH6 catalase H1Q60_RS08300 ENOG4107QHE Choloylglycine hydrolase H1Q60_RS08305 ENOG4105ETS cytosine purines uracil thiamine allantoin H1Q60_RS08310 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H1Q60_RS08315 ENOG4108JJ8 (ABC) transporter H1Q60_RS08320 ENOG4108JJ9 ABC, transporter H1Q60_RS08325 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H1Q60_RS08330 ENOG4105C4M (Ubiquinol oxidase) subunit I H1Q60_RS08335 ENOG4105D2K citrate carrier protein H1Q60_RS08340 ENOG4107BJW polysaccharide deacetylase H1Q60_RS08355 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) H1Q60_RS08365 ENOG4105CMR udp-glucose 4-epimerase H1Q60_RS08370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H1Q60_RS08390 ENOG4105DHI Methyltransferase H1Q60_RS08415 ENOG4105CH6 catalase H1Q60_RS08420 ENOG4105D4T Citrate transporter H1Q60_RS08440 ENOG4105C1J atp-dependent rna helicase H1Q60_RS08535 ENOG4108NR7 pectate lyase H1Q60_RS08545 ENOG4107YZX Universal stress protein H1Q60_RS08555 ENOG4105M6F mutator MutT protein H1Q60_RS08565 ENOG4106Z5D Glycoside Hydrolase Family 43 H1Q60_RS08575 ENOG4105C84 Histidine ammonia-lyase H1Q60_RS08580 ENOG4105CGP Urocanate hydratase H1Q60_RS08585 ENOG4105CI2 imidazolone-5-propionate hydrolase H1Q60_RS08590 ENOG4107W25 arginase agmatinase formiminoglutamase H1Q60_RS08600 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) H1Q60_RS08605 ENOG4105D9N nucleoside H1Q60_RS08610 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H1Q60_RS08615 ENOG4107RHR regulatoR H1Q60_RS08645 ENOG4108RDQ ABC transporter H1Q60_RS08655 ENOG410667J hydrolase H1Q60_RS08685 ENOG4108V5C ABC transporter H1Q60_RS08720 ENOG4105WZ4 isomerase H1Q60_RS08725 ENOG4105F0H myo-inositol catabolism protein H1Q60_RS08730 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H1Q60_RS08740 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) H1Q60_RS08750 ENOG4105EDK PfkB domain protein H1Q60_RS08760 ENOG4105C26 Dehydrogenase H1Q60_RS08770 ENOG4105CPC Aldo Keto reductase H1Q60_RS08775 ENOG4107QNK )-transporter H1Q60_RS08780 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H1Q60_RS08785 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H1Q60_RS08790 ENOG4108S01 response regulator H1Q60_RS08795 ENOG4108ZGX Histidine kinase H1Q60_RS08800 ENOG4105ECK Fatty Acid Desaturase H1Q60_RS08805 ENOG4105ST3 Transcriptional regulator H1Q60_RS08815 ENOG4105VZ8 Transcriptional regulator H1Q60_RS08845 ENOG4105C26 Dehydrogenase H1Q60_RS08860 ENOG4105WAB arsR family transcriptional regulator H1Q60_RS08865 ENOG4105F27 Major Facilitator H1Q60_RS08870 ENOG41085PJ rdd domain containing protein H1Q60_RS08880 ENOG4105D3R alkyl hydroperoxide reductase H1Q60_RS08885 ENOG4108JU3 Alkyl hydroperoxide reductase H1Q60_RS08890 ENOG4107R3N Filamentation induced by cAMP protein fic H1Q60_RS08895 ENOG4105C85 amino acid H1Q60_RS08900 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 H1Q60_RS08905 ENOG4108XHQ (2Fe-2S)-binding domain protein H1Q60_RS08925 ENOG4105XRQ Xanthine dehydrogenase accessory factor H1Q60_RS08945 ENOG4107QJE Chromosome Partitioning Protein H1Q60_RS08965 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H1Q60_RS08985 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) H1Q60_RS08990 ENOG4105CPC Aldo Keto reductase H1Q60_RS08995 ENOG4105WQG acetyltransferase H1Q60_RS09005 ENOG41066UZ arginase EC 3.5.3.1 H1Q60_RS09010 ENOG4108IQI permease H1Q60_RS09015 ENOG4105C8Y Acetylornithine aminotransferase H1Q60_RS09025 ENOG41082BM Transcriptional regulator, arsr family H1Q60_RS09030 ENOG4108JUB Transcriptional regulator H1Q60_RS09040 ENOG4105C5H ABC transporter H1Q60_RS09055 ENOG4105D06 uba thif-type nad fad binding protein H1Q60_RS09060 ENOG41062D9 Histidine kinase H1Q60_RS09065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS09075 ENOG4105C0H protease H1Q60_RS09080 ENOG4105Q2H domain protein H1Q60_RS09095 ENOG4105BZU Histidine kinase H1Q60_RS09100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS09125 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H1Q60_RS09130 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase H1Q60_RS09135 ENOG4105CDU Replicative dna helicase H1Q60_RS09155 ENOG4105EDW glycosyl transferase, family 39 H1Q60_RS09160 ENOG4107QPH glycogen) synthase H1Q60_RS09170 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H1Q60_RS09175 ENOG4105CPK Glycosyl transferase (Group 1 H1Q60_RS09195 ENOG4105BZR domain protein H1Q60_RS09200 ENOG4108XMW Membrane H1Q60_RS09215 ENOG4105KVH Transcriptional regulator H1Q60_RS09220 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase H1Q60_RS09225 ENOG4108UZ3 Transporter H1Q60_RS09230 ENOG4105EDQ levansucrase EC 2.4.1.10 H1Q60_RS09235 ENOG4108HKT sucrose-6-phosphate hydrolase H1Q60_RS09255 ENOG4106UX7 integral membrane protein H1Q60_RS09265 ENOG4108TVJ Nitroreductase H1Q60_RS09270 ENOG4105FS7 Transcriptional regulator H1Q60_RS09280 ENOG4108U05 Transcriptional regulator H1Q60_RS09285 ENOG41082BV acetyltransferase H1Q60_RS09295 ENOG4107Y9U Membrane H1Q60_RS09330 ENOG4108RDQ ABC transporter H1Q60_RS09345 ENOG4105C7Z Conserved Protein H1Q60_RS09370 ENOG4105K4H Nlp p60 protein H1Q60_RS09380 ENOG4105P1M Domain of unknown function (DUF1874) H1Q60_RS09440 ENOG4106128 DNA-binding helix-turn-helix protein H1Q60_RS09445 ENOG4106BHR ftsk SpoIIIE family protein H1Q60_RS09450 ENOG4108RYM conjugative transposon protein H1Q60_RS09470 ENOG4108IMY Transcriptional regulator H1Q60_RS09475 ENOG41068WC Domain of unknown function (DUF955) H1Q60_RS09480 ENOG4105C7Z Conserved Protein H1Q60_RS09485 ENOG4105C7Z Conserved Protein H1Q60_RS09490 ENOG4107FCW Abortive infection protein H1Q60_RS09500 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase H1Q60_RS09515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H1Q60_RS09525 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H1Q60_RS09530 ENOG4108UUM single-stranded DNA-binding protein H1Q60_RS09535 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) H1Q60_RS09540 ENOG4105C3G gtp-binding protein H1Q60_RS09545 ENOG4108J2R molybdopterin oxidoreductase H1Q60_RS09550 ENOG4105VDK protein, conserved in bacteria H1Q60_RS09565 ENOG4108ZDA Sporulation protein YyaC H1Q60_RS09570 ENOG4105FA0 parb-like partition protein H1Q60_RS09575 ENOG4107QJE Chromosome Partitioning Protein H1Q60_RS09590 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H1Q60_RS09595 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H1Q60_RS09610 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) H1Q60_RS09620 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H1Q60_RS09625 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H1Q60_RS09630 ENOG410848D S4 domain protein YaaA H1Q60_RS09635 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H1Q60_RS09645 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Q60_RS09650 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Q60_RS09685 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H1Q60_RS09695 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) H1Q60_RS09700 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) H1Q60_RS09705 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H1Q60_RS09710 ENOG4105BZW Glycerate kinase H1Q60_RS09720 ENOG4105ZMH deoxynucleoside kinase H1Q60_RS09730 ENOG4105VRS hydrolase family 18 H1Q60_RS09735 ENOG4105GTG Isochorismatase H1Q60_RS09740 ENOG4108Z6B deaminase H1Q60_RS09750 ENOG4105C6E dna polymerase iii H1Q60_RS09755 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H1Q60_RS09760 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H1Q60_RS09770 ENOG41067KS pro-sigma K processing H1Q60_RS09810 ENOG4105CDW Resistance protein H1Q60_RS09815 ENOG4105CXN decarboxylase H1Q60_RS09820 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) H1Q60_RS09825 ENOG4105X0R protein from nitrogen regulatory protein P-II H1Q60_RS09830 ENOG4105XVJ Protein of unknown function (DUF327) H1Q60_RS09835 ENOG4105FA2 dna polymerase iii H1Q60_RS09840 ENOG4105MA4 psp1 domain protein H1Q60_RS09850 ENOG41060K3 Methyltransferase H1Q60_RS09855 ENOG4105VC4 domain protein H1Q60_RS09860 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H1Q60_RS09865 ENOG4105KRN Transcriptional regulator, abrb family H1Q60_RS09870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H1Q60_RS09875 ENOG4105F8V Hydrolase, tatD family H1Q60_RS09880 ENOG41069ER domain protein H1Q60_RS09890 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H1Q60_RS09895 ENOG4105XFA sporulation peptidase YabG H1Q60_RS09900 ENOG4105W42 Veg protein H1Q60_RS09905 ENOG4105XEW small acid-soluble spore protein H1Q60_RS09910 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) H1Q60_RS09915 ENOG4105DFT pur operon repressor H1Q60_RS09920 ENOG4105KME endoribonuclease L-psp H1Q60_RS09925 ENOG4105K4W Could be involved in septation (By similarity) H1Q60_RS09930 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) H1Q60_RS09935 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H1Q60_RS09940 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H1Q60_RS09955 ENOG4108JA2 transcriptioN-repair coupling factor H1Q60_RS09960 ENOG4108M14 stage v sporulation protein t H1Q60_RS09970 ENOG4108IY2 MazG family H1Q60_RS09975 ENOG41082I2 s4 domain protein H1Q60_RS09980 ENOG4105VYY sporulation protein yabp H1Q60_RS09995 ENOG41060GV RNA binding s1 domain protein H1Q60_RS10025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H1Q60_RS10030 ENOG4108UGV hypoxanthine phosphoribosyltransferase H1Q60_RS10035 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H1Q60_RS10040 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) H1Q60_RS10045 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) H1Q60_RS10050 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase H1Q60_RS10055 ENOG4105C6T cysteine synthase H1Q60_RS10060 ENOG4105CRQ synthase (Component I) H1Q60_RS10065 ENOG4105DDQ anthranilate synthase H1Q60_RS10070 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 H1Q60_RS10075 ENOG4105EEI dihydropteroate synthase H1Q60_RS10080 ENOG4105KRF dihydroneopterin aldolase H1Q60_RS10085 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H1Q60_RS10095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H1Q60_RS10100 ENOG4105CRK lysyL-tRNA synthetase H1Q60_RS10185 ENOG4108Z0C Uvrb UvrC protein H1Q60_RS10190 ENOG41066A3 ATP guanido phosphotransferase H1Q60_RS10200 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H1Q60_RS10205 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) H1Q60_RS10210 ENOG4105CTP PilT protein domain protein H1Q60_RS10215 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) H1Q60_RS10220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) H1Q60_RS10225 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H1Q60_RS10230 ENOG4105D7W serine acetyltransferase H1Q60_RS10240 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) H1Q60_RS10245 ENOG4105C2N RNA methyltransferase TrmH family group 3 H1Q60_RS10250 ENOG4105M0M Tetracycline resistance protein H1Q60_RS10270 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H1Q60_RS10285 ENOG4108VZM 50s ribosomal protein L10 H1Q60_RS10295 ENOG4107Y49 methyltransferase H1Q60_RS10300 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Q60_RS10305 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Q60_RS10310 ENOG4105XPM ribosomal protein H1Q60_RS10315 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H1Q60_RS10320 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H1Q60_RS10325 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H1Q60_RS10330 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H1Q60_RS10335 ENOG4107SKW Inherit from COG: Alpha beta hydrolase H1Q60_RS10340 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) H1Q60_RS10345 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H1Q60_RS10350 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H1Q60_RS10360 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H1Q60_RS10375 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H1Q60_RS10390 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H1Q60_RS10405 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H1Q60_RS10415 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H1Q60_RS10420 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H1Q60_RS10425 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H1Q60_RS10430 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H1Q60_RS10440 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) H1Q60_RS10445 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H1Q60_RS10450 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H1Q60_RS10455 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H1Q60_RS10465 ENOG41067V7 50S ribosomal protein L36 H1Q60_RS10470 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H1Q60_RS10475 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H1Q60_RS10480 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H1Q60_RS10485 ENOG4108ZT0 50S ribosomal protein l17 H1Q60_RS10490 ENOG4108JJB ABC transporter H1Q60_RS10495 ENOG4108JJB ABC transporter H1Q60_RS10500 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) H1Q60_RS10505 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H1Q60_RS10510 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H1Q60_RS10515 ENOG4108UJD 30S ribosomal protein S9 H1Q60_RS10520 ENOG4108I0C methyltransferase H1Q60_RS10540 ENOG4105D1F ATP-binding protein H1Q60_RS10555 ENOG4108NMV polysaccharide deacetylase H1Q60_RS10620 ENOG4108JPW Aminotransferase H1Q60_RS10630 ENOG4105CPQ Dehydrogenase H1Q60_RS10635 ENOG4105CHH sulfate transporter H1Q60_RS10645 ENOG4108SA1 esterase H1Q60_RS10665 ENOG410874W AraC family transcriptional regulator H1Q60_RS10670 ENOG4105EHZ conserved protein UCP016719 H1Q60_RS10675 ENOG4105D17 glycoside hydrolase, family 3 domain protein H1Q60_RS10690 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H1Q60_RS10700 ENOG4105EWC Purine nucleoside phosphorylase H1Q60_RS10730 ENOG4105EMN RNA polymerase sigma factor H1Q60_RS10740 ENOG4105C8B TIGR00159 family H1Q60_RS10745 ENOG4107U5W ybbr family H1Q60_RS10750 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) H1Q60_RS10775 ENOG4106K80 H1Q60_RS10785 ENOG41067MG lrgb family H1Q60_RS10795 ENOG41061AU MarR family Transcriptional regulator H1Q60_RS10810 ENOG4105BZU Histidine kinase H1Q60_RS10815 ENOG4105WH1 Two component transcriptional regulator luxr family H1Q60_RS10820 ENOG4105CJ1 ABC, transporter H1Q60_RS10845 ENOG4106DDH Sporulation-specific SASP protein H1Q60_RS10860 ENOG4107QTZ amino acid H1Q60_RS10885 ENOG4107VXM glycerophosphoryl diester phosphodiesterase H1Q60_RS10890 ENOG4105CXY transporter H1Q60_RS10925 ENOG4107SCQ Iron-containing alcohol dehydrogenase H1Q60_RS10930 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H1Q60_RS10935 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase H1Q60_RS10940 ENOG4107ZTW SNARE associated Golgi H1Q60_RS10955 ENOG4105C72 UPF0176 protein H1Q60_RS10965 ENOG4105CM2 brancheD-chain amino acid aminotransferase H1Q60_RS10970 ENOG4108IQI permease H1Q60_RS10975 ENOG4108J5H Homocysteine s-methyltransferase H1Q60_RS10985 ENOG4105CSV Glutaminase H1Q60_RS11020 ENOG4105DGI Alkaline phosphatase H1Q60_RS11025 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H1Q60_RS11030 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H1Q60_RS11035 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) H1Q60_RS11040 ENOG4107EPV Aminotransferase class V H1Q60_RS11045 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Q60_RS11050 ENOG4105J7D transcriptional regulator H1Q60_RS11055 ENOG4107RB3 L-asparaginase H1Q60_RS11060 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold H1Q60_RS11065 ENOG41060AI SEC-C motif H1Q60_RS11070 ENOG4107SET aldo keto reductase H1Q60_RS11100 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H1Q60_RS11130 ENOG4105DSE periplasmic solute binding protein H1Q60_RS11135 ENOG4105DIK (ABC) transporter H1Q60_RS11145 ENOG4105DEN Luciferase family H1Q60_RS11150 ENOG4108N0M stress protein H1Q60_RS11155 ENOG4106FN3 tellurium resistance protein H1Q60_RS11160 ENOG4106FN3 tellurium resistance protein H1Q60_RS11165 ENOG4107TS3 membrane protein, TerC H1Q60_RS11170 ENOG4108TTB tellurium resistance protein H1Q60_RS11180 ENOG41079KZ Major Facilitator Superfamily H1Q60_RS11185 ENOG4108IJ7 Glycine betaine H1Q60_RS11190 ENOG4107SQ8 Glycine betaine H1Q60_RS11220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) H1Q60_RS11310 ENOG4105EIG urea carboxylase-associated protein 1 H1Q60_RS11315 ENOG4107RA1 nh(3)-dependent nad( ) synthetase H1Q60_RS11325 ENOG4105I1F Resistance protein H1Q60_RS11335 ENOG4105DJB Major Facilitator Superfamily H1Q60_RS11340 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H1Q60_RS11345 ENOG4105I82 acetyl xylan esterase H1Q60_RS11350 ENOG410756H nucleotidyltransferase H1Q60_RS11360 ENOG4105C26 Dehydrogenase H1Q60_RS11365 ENOG4105CK7 Sodium proline symporter H1Q60_RS11370 ENOG4107YHD transcriptional regulator H1Q60_RS11375 ENOG4105CAY ferredoxin--nadp reductase H1Q60_RS11380 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H1Q60_RS11385 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit H1Q60_RS11390 ENOG4108IFG nitrite reductase, (NAD(P)H) H1Q60_RS11395 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) H1Q60_RS11410 ENOG4105CKI cobalamin synthesis protein H1Q60_RS11415 ENOG4105E2A Dehydrogenase H1Q60_RS11420 ENOG4105HHM rdd domain containing protein H1Q60_RS11445 ENOG41080HJ 6-phospho 3-hexuloisomerase H1Q60_RS11450 ENOG4108VA3 3-hexulose-6-phosphate synthase H1Q60_RS11455 ENOG4105KVH Transcriptional regulator H1Q60_RS11460 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS11495 ENOG4105CDA abc transporter atp-binding protein H1Q60_RS11500 ENOG4105DRP amino acid AbC transporter H1Q60_RS11510 ENOG4106P55 Transcriptional regulator H1Q60_RS11515 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H1Q60_RS11520 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H1Q60_RS11525 ENOG41069ZX H1Q60_RS11530 ENOG41069ZX H1Q60_RS11535 ENOG4105DUX Transporter H1Q60_RS11550 ENOG4105E1K spore germination protein H1Q60_RS11575 ENOG4105EAB amino acid AbC transporter H1Q60_RS11580 ENOG4108HW4 amino acid AbC transporter H1Q60_RS11595 ENOG4108PGP mmge prpd family protein H1Q60_RS11605 ENOG4107WD8 ABC transporter, permease H1Q60_RS11610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS11615 ENOG4105BZU Histidine kinase H1Q60_RS11635 ENOG4105CFH Aspartokinase H1Q60_RS11640 ENOG4105DHS permease protein H1Q60_RS11645 ENOG4105CM4 permease protein H1Q60_RS11650 ENOG4108IPW abc transporter atp-binding protein H1Q60_RS11665 ENOG4105R8C Transcriptional regulator H1Q60_RS11670 ENOG4108DBC nitroreductase H1Q60_RS11675 ENOG41067V3 Antibiotic biosynthesis monooxygenase H1Q60_RS11680 ENOG4105YVS arsR family transcriptional regulator H1Q60_RS11690 ENOG4108JPW Aminotransferase H1Q60_RS11695 ENOG4105C26 Dehydrogenase H1Q60_RS11705 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H1Q60_RS11710 ENOG4105KTB nuclear export factor GLE1 H1Q60_RS11715 ENOG4108T5E Copper resistance protein H1Q60_RS11720 ENOG4108ZYE Transcriptional regulator H1Q60_RS11740 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase H1Q60_RS11765 ENOG4105E7W lamb ycsf family protein H1Q60_RS11770 ENOG4105C5A transporter H1Q60_RS11780 ENOG4105P4J Allophanate hydrolase, subunit 1 H1Q60_RS11790 ENOG4107258 Transcriptional regulator H1Q60_RS11795 ENOG4105XJB lipolytic protein G-D-S-L family H1Q60_RS11805 ENOG41061CK Antibiotic biosynthesis monooxygenase H1Q60_RS11810 ENOG4107RVG penicillin-binding protein H1Q60_RS11815 ENOG4107QM2 Aldo Keto reductase H1Q60_RS11820 ENOG4105ETD TRANSCRIPTIONal H1Q60_RS11830 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H1Q60_RS11845 ENOG410606W general stress protein H1Q60_RS11855 ENOG4105VCH membrane H1Q60_RS11865 ENOG4105C9U ATP-dependent DNA helicase RecQ H1Q60_RS11880 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) H1Q60_RS11885 ENOG4107R8N Glycosyl transferase, family 2 H1Q60_RS11895 ENOG4105C0X amino acid H1Q60_RS11915 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase H1Q60_RS11950 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) H1Q60_RS11965 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) H1Q60_RS11970 ENOG4105RXJ H1Q60_RS11975 ENOG4105KPY Small multidrug resistance protein H1Q60_RS11980 ENOG4105EU9 H1Q60_RS11985 ENOG4105QVS general stress protein H1Q60_RS11990 ENOG41082W1 Cupin 2, conserved barrel domain protein H1Q60_RS12005 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H1Q60_RS12010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H1Q60_RS12015 ENOG4108MRH transcriptional regulatory protein H1Q60_RS12020 ENOG4107QJT sodium dicarboxylate symporter H1Q60_RS12025 ENOG4106F5Q Membrane H1Q60_RS12030 ENOG4105CJ1 ABC, transporter H1Q60_RS12045 ENOG4105FDT acyl-CoA dehydrogenase H1Q60_RS12065 ENOG4105SZ6 Thioredoxin H1Q60_RS12070 ENOG4105CPF Cell wall formation (By similarity) H1Q60_RS12075 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) H1Q60_RS12080 ENOG4105C1J atp-dependent rna helicase H1Q60_RS12085 ENOG410905X membrane-flanked domain protein H1Q60_RS12090 ENOG4105CKV Membrane H1Q60_RS12100 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) H1Q60_RS12105 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein H1Q60_RS12110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H1Q60_RS12120 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) H1Q60_RS12125 ENOG4107MMM Anti-sigma-factor antagonist H1Q60_RS12130 ENOG4105FUA antagonist H1Q60_RS12135 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase H1Q60_RS12140 ENOG4107SGM protein serine threonine phosphatase H1Q60_RS12145 ENOG4105WN5 stage II sporulation protein H1Q60_RS12150 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) H1Q60_RS12160 ENOG41064BQ Phosphatase H1Q60_RS12175 ENOG410906U SprT-like H1Q60_RS12230 ENOG4105C94 Transporter H1Q60_RS12235 ENOG4105CSH Transporter H1Q60_RS12245 ENOG4108ZMQ domain protein H1Q60_RS12260 ENOG4108Z40 Transcriptional regulator H1Q60_RS12265 ENOG4108RYK Nad-dependent epimerase dehydratase H1Q60_RS12275 ENOG4105VEQ Cold shock protein H1Q60_RS12280 ENOG4108VJ1 Transcriptional regulator (CarD family H1Q60_RS12285 ENOG4105XTG Pfam:DUF156 H1Q60_RS12290 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase H1Q60_RS12295 ENOG4105C72 UPF0176 protein H1Q60_RS12300 ENOG4105VFE sira family H1Q60_RS12305 ENOG4107TPS domain protein H1Q60_RS12310 ENOG4105VFE sira family H1Q60_RS12315 ENOG41087NI Sulfite exporter TauE/SafE H1Q60_RS12335 ENOG4105IRW patatin-like phospholipase family protein H1Q60_RS12345 ENOG41082W1 Cupin 2, conserved barrel domain protein H1Q60_RS12365 ENOG4105DNP FAD linked oxidase domain protein H1Q60_RS12375 ENOG4105PGM cation diffusion facilitator family transporter H1Q60_RS12390 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein H1Q60_RS12400 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H1Q60_RS12425 ENOG4105DQ4 alcohol dehydrogenase H1Q60_RS12430 ENOG4105VUF Transcriptional regulator H1Q60_RS12440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H1Q60_RS12455 ENOG4105EQ0 Major Facilitator superfamily H1Q60_RS12460 ENOG4108JGH Tetr family transcriptional regulator H1Q60_RS12465 ENOG4105T38 integral membrane protein H1Q60_RS12470 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H1Q60_RS12485 ENOG4105E2A Dehydrogenase H1Q60_RS12490 ENOG4105PGS Spore coat protein H1Q60_RS12500 ENOG4105ENE Histidine kinase H1Q60_RS12505 ENOG4108VB1 regulatoR H1Q60_RS12510 ENOG4105EYF MMPL domain protein H1Q60_RS12530 ENOG4108JYZ YitT family H1Q60_RS12540 ENOG4105C2C drug resistance transporter, Bcr CflA H1Q60_RS12545 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H1Q60_RS12565 ENOG41090E6 transcriptional regulator MERR family H1Q60_RS12580 ENOG4105F2W methyltransferase H1Q60_RS12585 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H1Q60_RS12590 ENOG4105DRR Transcriptional regulator, GntR family H1Q60_RS12610 ENOG4105FQP Beta-lactamase H1Q60_RS12620 ENOG41090UD (LipO)protein H1Q60_RS12625 ENOG4108SUT Major Facilitator Superfamily H1Q60_RS12630 ENOG4108TZY GntR Family Transcriptional Regulator H1Q60_RS12635 ENOG4105JXH GntR family transcriptional regulator H1Q60_RS12640 ENOG4105DJ2 Major Facilitator Superfamily H1Q60_RS12660 ENOG4107QTZ amino acid H1Q60_RS12680 ENOG4107QNK )-transporter H1Q60_RS12720 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H1Q60_RS12725 ENOG4105K8N protein family UPF0079, ATPase H1Q60_RS12730 ENOG41072GX Peptidase M22 Glycoprotease H1Q60_RS12735 ENOG410801F ribosomal-protein-alanine acetyltransferase H1Q60_RS12740 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H1Q60_RS12745 ENOG4105C5H ABC transporter H1Q60_RS12750 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) H1Q60_RS12755 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) H1Q60_RS12760 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H1Q60_RS12765 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H1Q60_RS12775 ENOG4108TYN CAAX amino terminal protease family protein H1Q60_RS12785 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H1Q60_RS12790 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H1Q60_RS12800 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H1Q60_RS12825 ENOG4105CZM Major Facilitator H1Q60_RS12830 ENOG4105PGZ NB-ARC domain H1Q60_RS12835 ENOG4105CPQ Dehydrogenase H1Q60_RS12840 ENOG4105CT4 transporter H1Q60_RS12855 ENOG41087YS Phage shock protein A H1Q60_RS12860 ENOG4105DQX Zinc finger domain H1Q60_RS12865 ENOG4108WV1 Pfam:DUF477 H1Q60_RS12875 ENOG4105EXC Acyl-transferase H1Q60_RS12880 ENOG4108P49 AntiSigma factor H1Q60_RS12885 ENOG4105JVQ RNA Polymerase H1Q60_RS12915 ENOG4107STQ Multicopper oxidase H1Q60_RS12920 ENOG4105C85 amino acid H1Q60_RS12930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H1Q60_RS12945 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H1Q60_RS12950 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H1Q60_RS12965 ENOG4105E5W Transporter H1Q60_RS12980 ENOG4105C7N Xanthine uracil vitamin C permease H1Q60_RS13005 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H1Q60_RS13010 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H1Q60_RS13015 ENOG4105C83 adenylosuccinate lyase H1Q60_RS13020 ENOG4105C8V SAICAR synthetase H1Q60_RS13025 ENOG4105VR9 phosphoribosylformylglycinamidine synthase H1Q60_RS13030 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I H1Q60_RS13035 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii H1Q60_RS13045 ENOG4105CXB phosphoribosylaminoimidazole synthetase H1Q60_RS13050 ENOG4108V3E phosphoribosylglycinamide formyltransferase H1Q60_RS13055 ENOG4105DC1 bifunctional purine biosynthesis protein purh H1Q60_RS13060 ENOG4105C12 Phosphoribosylglycinamide synthetase H1Q60_RS13075 ENOG4108R5T secreted protein H1Q60_RS13080 ENOG4105KGF protein, YerC YecD H1Q60_RS13085 ENOG4105CBC glutamate synthase H1Q60_RS13095 ENOG4105C4R Atp-dependent dna helicase H1Q60_RS13100 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H1Q60_RS13110 ENOG4105CRN Aminoglycoside phosphotransferase H1Q60_RS13115 ENOG4105KT7 mgtC SapB transporter H1Q60_RS13120 ENOG4105CK7 Sodium proline symporter H1Q60_RS13125 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H1Q60_RS13130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) H1Q60_RS13135 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) H1Q60_RS13140 ENOG4108IG5 Transcriptional regulator H1Q60_RS13150 ENOG4105CBD Diacylglycerol kinase H1Q60_RS13155 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H1Q60_RS13170 ENOG4105CAQ asparagine synthetase H1Q60_RS13205 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H1Q60_RS13215 ENOG4105CJ1 ABC, transporter H1Q60_RS13255 ENOG4106BHF H1Q60_RS13260 ENOG4105CDY transcriptional regulatory protein H1Q60_RS13270 ENOG41075D4 Aminoglycoside 6-adenylyltransferase H1Q60_RS13285 ENOG4105WEF catalase H1Q60_RS13290 ENOG4105M18 -acetyltransferase H1Q60_RS13300 ENOG4105H67 Protein of unknown function (DUF421) H1Q60_RS13305 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) H1Q60_RS13310 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily H1Q60_RS13320 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H1Q60_RS13325 ENOG4108I5D sulfate abc transporter H1Q60_RS13350 ENOG4106I4J membrane H1Q60_RS13355 ENOG41082F9 transcriptional regulator H1Q60_RS13360 ENOG41061H0 Monooxygenase H1Q60_RS13365 ENOG4108R1P H1Q60_RS13370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) H1Q60_RS13385 ENOG4105CJ1 ABC, transporter H1Q60_RS13395 ENOG4105E0M Sulfatase H1Q60_RS13400 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase H1Q60_RS13410 ENOG41090R9 glycosyltransferase H1Q60_RS13415 ENOG4107R51 Glycosyl transferase, family 2 H1Q60_RS13425 ENOG4105EU0 Major facilitator Superfamily H1Q60_RS13430 ENOG4105CUB amino acid H1Q60_RS13435 ENOG4105C26 Dehydrogenase H1Q60_RS13440 ENOG4105FKZ Methyl-accepting chemotaxis H1Q60_RS13445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H1Q60_RS13450 ENOG4107TVC Glycosyl transferase, family 2 H1Q60_RS13455 ENOG4105C5H ABC transporter H1Q60_RS13460 ENOG4107SWG transcriptional regulator MERR family H1Q60_RS13465 ENOG4105DXB Major Facilitator superfamily H1Q60_RS13470 ENOG4105C5H ABC transporter H1Q60_RS13475 ENOG4105FDU atp-dependent rna helicase H1Q60_RS13485 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H1Q60_RS13500 ENOG4108J20 pectate lyase H1Q60_RS13505 ENOG4107QPK )-transporter H1Q60_RS13525 ENOG4108MRH transcriptional regulatory protein H1Q60_RS13550 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) H1Q60_RS13555 ENOG4108RPX mosc domain containing protein H1Q60_RS13575 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) H1Q60_RS13615 ENOG4105C5Y PTS System H1Q60_RS13620 ENOG4105CG3 alpha amylase, catalytic region H1Q60_RS13625 ENOG4107414 GntR family transcriptional regulator H1Q60_RS13630 ENOG4108RCM Nitroreductase H1Q60_RS13645 ENOG4105CGH 5'-nucleotidase H1Q60_RS13650 ENOG4107RKG DJ-1/PfpI family H1Q60_RS13655 ENOG4105ETE Transcriptional regulator (LacI family H1Q60_RS13665 ENOG4105FF2 Type I DHQase H1Q60_RS13680 ENOG4105KJF protein tyrosine phosphatase H1Q60_RS13690 ENOG4107U9T Pfam:Ribonuclease_BN H1Q60_RS13700 ENOG4108ISG Major Facilitator H1Q60_RS13705 ENOG4105UPD Calcium Proton H1Q60_RS13715 ENOG4105D8X mechanosensitive ion channel H1Q60_RS13735 ENOG4106KE4 Dehydrogenase H1Q60_RS13745 ENOG4105D7N magnesium and cobalt transport protein CorA H1Q60_RS13755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H1Q60_RS13780 ENOG4107RUY (E1 component), alpha subunit H1Q60_RS13790 ENOG4107QKR Dehydrogenase H1Q60_RS13800 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H1Q60_RS13810 ENOG4105F8D glycoside hydrolase family 4 H1Q60_RS13815 ENOG4108Q3X Transcriptional regulator H1Q60_RS13820 ENOG4105CI1 PTS System H1Q60_RS13825 ENOG4105BZ1 (ABC) transporter H1Q60_RS13830 ENOG4105BZ1 (ABC) transporter H1Q60_RS13840 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase H1Q60_RS13845 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H1Q60_RS13850 ENOG4105U3E Transcriptional regulator H1Q60_RS13855 ENOG4105DYS nad(p)h dehydrogenase (quinone) H1Q60_RS13860 ENOG4105H93 Acyltransferase family H1Q60_RS13875 ENOG4108YYS metal-dependent hydrolase (By similarity) H1Q60_RS13880 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Q60_RS13885 ENOG410834F Transcriptional regulator H1Q60_RS13895 ENOG4105JAB phenazine biosynthesis protein, phzf family H1Q60_RS13900 ENOG4107Y03 Nitroreductase H1Q60_RS13915 ENOG4105ECP epimerase H1Q60_RS13920 ENOG410902V Modulates RecA activity (By similarity) H1Q60_RS13930 ENOG4105F27 Major Facilitator H1Q60_RS13940 ENOG4108TCS Glutamyl endopeptidase H1Q60_RS13960 ENOG4106AKJ H1Q60_RS13965 ENOG4105D74 hydrolase H1Q60_RS13970 ENOG4105CKK Glycosyl transferase, family 2 H1Q60_RS13975 ENOG4105EJV Membrane H1Q60_RS13980 ENOG41067AE Membrane-bound metal-dependent hydrolase H1Q60_RS13985 ENOG4105VTR Integrase H1Q60_RS14025 ENOG4108ZUE Phage regulatory protein rha H1Q60_RS14050 ENOG4105CDU Replicative dna helicase H1Q60_RS14080 ENOG410682Q Phage transcriptional regulator, ArpU H1Q60_RS14090 ENOG4105CNU cell division protein FtsK H1Q60_RS14125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H1Q60_RS14165 ENOG4108FKH Transglycosylase SLT domain H1Q60_RS14215 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H1Q60_RS14245 ENOG4105CEN a g-specific adenine glycosylase H1Q60_RS14250 ENOG4106BXE H1Q60_RS14255 ENOG4105CAN Short-chain dehydrogenase reductase Sdr H1Q60_RS14275 ENOG4105BZ1 (ABC) transporter H1Q60_RS14280 ENOG4107NBY Membrane H1Q60_RS14285 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H1Q60_RS14290 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H1Q60_RS14295 ENOG4105G5W regulator Fur family H1Q60_RS14300 ENOG4105TUA UPF0295 protein H1Q60_RS14440 ENOG4105EC3 peptidase S51, dipeptidase E H1Q60_RS14445 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) H1Q60_RS14450 ENOG4105DNP FAD linked oxidase domain protein H1Q60_RS14460 ENOG4105DEF Extracellular solute-binding protein, family 5 H1Q60_RS14470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Q60_RS14475 ENOG4105C3U ABC transporter H1Q60_RS14480 ENOG4108JQ7 (ABC) transporter H1Q60_RS14495 ENOG4105E2Y ABC, transporter H1Q60_RS14500 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein H1Q60_RS14505 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H1Q60_RS14520 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H1Q60_RS14525 ENOG4107D63 H1Q60_RS14530 ENOG4105VZ8 Transcriptional regulator H1Q60_RS14545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H1Q60_RS14555 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H1Q60_RS14575 ENOG4105CYN Serine protein kinase H1Q60_RS14585 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H1Q60_RS14590 ENOG4105CW7 secretion protein, HlyD family H1Q60_RS14595 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Q60_RS14600 ENOG4105CS1 NAD(P)H quinone oxidoreductase H1Q60_RS14615 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family H1Q60_RS14620 ENOG4105CZV ABC transporter H1Q60_RS14625 ENOG4105CJ1 ABC, transporter H1Q60_RS14630 ENOG4108TU7 Inherit from COG: (ABC) transporter H1Q60_RS14635 ENOG4105VEQ Cold shock protein H1Q60_RS14645 ENOG4105BZU Histidine kinase H1Q60_RS14685 ENOG4108YBP pseudouridine synthase H1Q60_RS14695 ENOG41080XP Cbs domain H1Q60_RS14700 ENOG4107YBY Hydrolase H1Q60_RS14705 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H1Q60_RS14710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Q60_RS14715 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator H1Q60_RS14725 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) H1Q60_RS14730 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H1Q60_RS14740 ENOG4105BZU Histidine kinase H1Q60_RS14745 ENOG4105WH1 Two component transcriptional regulator luxr family H1Q60_RS14780 ENOG4105ED1 spovr family H1Q60_RS14785 ENOG4105G6Z alkaline phosphatase H1Q60_RS14800 ENOG4105BZN citrate synthase H1Q60_RS14805 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H1Q60_RS14810 ENOG4105CUB amino acid H1Q60_RS14815 ENOG4105C8J )-transporter H1Q60_RS14825 ENOG4105J37 H1Q60_RS14830 ENOG4108AEY RNA polymerase sigma factor H1Q60_RS14835 ENOG4105F6E Acyl-transferase H1Q60_RS14840 ENOG4105C37 (CBS) domain H1Q60_RS14850 ENOG4105CHM Aminotransferase H1Q60_RS14855 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase H1Q60_RS14860 ENOG4105C37 (CBS) domain H1Q60_RS14870 ENOG4105WMR Protein CrcB homolog H1Q60_RS14875 ENOG4108QXE glycerophosphoryl diester phosphodiesterase H1Q60_RS14885 ENOG4105D64 Mechanosensitive ion channel H1Q60_RS14890 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H1Q60_RS14895 ENOG4107VMI polysaccharide deacetylase H1Q60_RS14900 ENOG4105F0I Aminotransferase H1Q60_RS14905 ENOG4105W1N transcriptional regulator H1Q60_RS14910 ENOG4105IIP Membrane H1Q60_RS14920 ENOG4105BZ1 (ABC) transporter H1Q60_RS14925 ENOG4105BZ1 (ABC) transporter H1Q60_RS14945 ENOG410839P H1Q60_RS14955 ENOG4106MP8 UPF0754 membrane protein H1Q60_RS14960 ENOG4105WZB UPF0342 protein H1Q60_RS14965 ENOG4105F1N DNA alkylation repair H1Q60_RS14975 ENOG4105D4P Coproporphyrinogen iii oxidase H1Q60_RS14985 ENOG4107S91 Sodium hydrogen exchanger H1Q60_RS14990 ENOG4105NCW Trka-c domain protein H1Q60_RS15000 ENOG4105CGU Enoyl-CoA hydratase H1Q60_RS15010 ENOG4108IUX (ABC) transporter H1Q60_RS15015 ENOG4105RHA ABC transporter, permease H1Q60_RS15020 ENOG4107VRP DNA repair exonuclease H1Q60_RS15025 ENOG4106D4I domain protein H1Q60_RS15030 ENOG4105EQI Metal Dependent Phosphohydrolase H1Q60_RS15040 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H1Q60_RS15085 ENOG4105NBU tryptophan transport protein H1Q60_RS15090 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H1Q60_RS15095 ENOG4105K59 histidine triad (HIT) protein H1Q60_RS15125 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation H1Q60_RS15130 ENOG4105BZ4 penicillin-binding protein H1Q60_RS15135 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H1Q60_RS15140 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H1Q60_RS15145 ENOG4105C1Q protoporphyrinogen oxidase H1Q60_RS15155 ENOG4105ECB domain protein H1Q60_RS15170 ENOG4105DER m42 family H1Q60_RS15180 ENOG4106AXD H1Q60_RS15185 ENOG4108RQ5 Beta-lactamase domain-containing protein H1Q60_RS15190 ENOG4105DF9 Lipoate-protein, ligase H1Q60_RS15200 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS15210 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 H1Q60_RS15220 ENOG4108HUF Transporter H1Q60_RS15225 ENOG4107TB6 phosphoglycerate mutase H1Q60_RS15235 ENOG4107F3J Amp-dependent synthetase and ligase H1Q60_RS15240 ENOG4107ZYJ bioY protein H1Q60_RS15245 ENOG4106YBV Methyl-accepting chemotaxis H1Q60_RS15265 ENOG4105XVF Competence transcription factor H1Q60_RS15280 ENOG4108IG5 Transcriptional regulator H1Q60_RS15290 ENOG4108QY0 Membrane H1Q60_RS15295 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination H1Q60_RS15300 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H1Q60_RS15310 ENOG4105EYH Exonuclease H1Q60_RS15355 ENOG4105ERH Fumarylacetoacetate hydrolase H1Q60_RS15370 ENOG4105CAQ asparagine synthetase H1Q60_RS15380 ENOG4105UQX Mate efflux family protein H1Q60_RS15385 ENOG4106HBX Transcriptional Regulator AraC Family H1Q60_RS15390 ENOG4105ETE Transcriptional regulator (LacI family H1Q60_RS15395 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H1Q60_RS15400 ENOG4105SF0 DinB family H1Q60_RS15405 ENOG4108ZUB Lysine exporter protein (Lyse ygga) H1Q60_RS15410 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H1Q60_RS15415 ENOG4105MYW Pentapeptide repeat protein H1Q60_RS15420 ENOG4105MA6 gCN5-related N-acetyltransferase H1Q60_RS15430 ENOG4108VPT UPF0234 protein H1Q60_RS15435 ENOG4105QNR S1 RNA binding domain protein H1Q60_RS15440 ENOG4105DIH basic membrane H1Q60_RS15445 ENOG4105C8Q Methyl-accepting chemotaxis H1Q60_RS15455 ENOG4105EPR degv family H1Q60_RS15460 ENOG4107AYK membrAne H1Q60_RS15470 ENOG41073B9 H1Q60_RS15480 ENOG4108KP7 hydrolase H1Q60_RS15485 ENOG4108MXZ Esterase H1Q60_RS15490 ENOG4105VG1 fes assembly suf system protein H1Q60_RS15495 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) H1Q60_RS15500 ENOG4105IQ5 FAD linked oxidase domain protein H1Q60_RS15510 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H1Q60_RS15515 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) H1Q60_RS15520 ENOG4105CAS nag kinase H1Q60_RS15525 ENOG4105C8Y Acetylornithine aminotransferase H1Q60_RS15530 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H1Q60_RS15540 ENOG4105DBV ornithine carbamoyltransferase H1Q60_RS15565 ENOG4107RMD Basic membrane lipoprotein H1Q60_RS15580 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H1Q60_RS15585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H1Q60_RS15595 ENOG4105C3U ABC transporter H1Q60_RS15600 ENOG4108JQ7 (ABC) transporter H1Q60_RS15615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Q60_RS15625 ENOG4105C31 Tryptophanyl-tRNA synthetase H1Q60_RS15630 ENOG4108J59 Extracellular solute-binding protein, family 5 H1Q60_RS15635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Q60_RS15640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Q60_RS15650 ENOG4108JQ7 (ABC) transporter H1Q60_RS15665 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) H1Q60_RS15670 ENOG4108ZCF integral membrane protein H1Q60_RS15675 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis H1Q60_RS15685 ENOG4105DPN Oligoendopeptidase f H1Q60_RS15695 ENOG4105T58 Dithiol-disulfide isomerase H1Q60_RS15700 ENOG4108Z18 K06886 hemoglobin H1Q60_RS15705 ENOG4105E4C Lytic transglycosylase catalytic H1Q60_RS15710 ENOG4105MIX Adenylate cyclase H1Q60_RS15725 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H1Q60_RS15730 ENOG4105EMS pseudouridine synthase H1Q60_RS15735 ENOG4107S1Q Phosphatase H1Q60_RS15745 ENOG4105ETU transcriptional activator (TenA H1Q60_RS15750 ENOG4108VEU Thiamine monophosphate synthase H1Q60_RS15770 ENOG4105D06 uba thif-type nad fad binding protein H1Q60_RS15775 ENOG4105DWF phosphomethylpyrimidine kinase H1Q60_RS15780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H1Q60_RS15785 ENOG4107A88 H1Q60_RS15835 ENOG4105ENA helicase H1Q60_RS15855 ENOG4105CJ1 ABC, transporter H1Q60_RS15870 ENOG4108ZMI UPF0477 protein H1Q60_RS15880 ENOG4105C28 cystathionine H1Q60_RS15885 ENOG4105C28 cystathionine H1Q60_RS15895 ENOG4105VTR Integrase H1Q60_RS15945 ENOG4105ZUG H1Q60_RS16130 ENOG4106BHF H1Q60_RS16145 ENOG410907G H1Q60_RS16175 ENOG4105C0R drug resistance transporter emrb qaca subfamily H1Q60_RS16190 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase H1Q60_RS16195 ENOG4105CMR udp-glucose 4-epimerase H1Q60_RS16200 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) H1Q60_RS16205 ENOG4105CK1 PTS System H1Q60_RS16210 ENOG4105VCP PTS System H1Q60_RS16245 ENOG4105KT7 mgtC SapB transporter H1Q60_RS16270 ENOG4108IEG Formate dehydrogenase Alpha subunit H1Q60_RS16280 ENOG4106A3M Cytochrome p-450 H1Q60_RS16285 ENOG41087PP glycosyltransferase MGT family H1Q60_RS16295 ENOG4105EXQ uroporphyrinogen iii synthase hem4 H1Q60_RS16300 ENOG4105C4B ABC transporter, permease H1Q60_RS16305 ENOG4108IXI (ABC) transporter H1Q60_RS16315 ENOG4105Q95 Cupin 2, conserved barrel domain protein H1Q60_RS16340 ENOG4107KJX Transcriptional regulator H1Q60_RS16345 ENOG4107QZW Altronate oxidoreductase H1Q60_RS16350 ENOG4105CTX dehydratase H1Q60_RS16355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H1Q60_RS16360 ENOG4105F3H Histidine kinase H1Q60_RS16380 ENOG4105BZU Histidine kinase H1Q60_RS16400 ENOG4108JJA ABC, transporter H1Q60_RS16420 ENOG4107TSN permease H1Q60_RS16440 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase H1Q60_RS16445 ENOG4105KWG Pfam:DUF1696 H1Q60_RS16450 ENOG4105K7W phage-related replication protein H1Q60_RS16455 ENOG410635T phage-like element pbsx protein H1Q60_RS16500 ENOG4105X7F H1Q60_RS16535 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase H1Q60_RS16550 ENOG4105CJ3 phosphate transporter H1Q60_RS16555 ENOG4107GRR phosphate transport regulator H1Q60_RS16560 ENOG4107R7I amino acid H1Q60_RS16570 ENOG4105EDW glycosyl transferase, family 39 H1Q60_RS16575 ENOG4105CKK Glycosyl transferase, family 2 H1Q60_RS16585 ENOG4105C0H protease H1Q60_RS16595 ENOG4108ME1 Peptidase M55 D-aminopeptidase H1Q60_RS16600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H1Q60_RS16605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H1Q60_RS16610 ENOG4105C3U ABC transporter H1Q60_RS16620 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H1Q60_RS16625 ENOG4105DTQ mandelate racemase muconate lactonizing H1Q60_RS16630 ENOG4107SN7 NLP P60 protein H1Q60_RS16635 ENOG4108JQ7 (ABC) transporter H1Q60_RS16640 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) H1Q60_RS16645 ENOG4107TUM Amidinotransferase H1Q60_RS16650 ENOG4108S4H thioesterase Superfamily protein H1Q60_RS16655 ENOG4108428 Inherit from COG: -acetyltransferase H1Q60_RS16665 ENOG41080TC multidrug resistance protein H1Q60_RS16670 ENOG4105CIY formyltetrahydrofolate deformylase H1Q60_RS16675 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H1Q60_RS16690 ENOG4105K56 Transcriptional regulator H1Q60_RS16695 ENOG4108ZHJ Organic hydroperoxide resistance protein H1Q60_RS16710 ENOG4107TVC Glycosyl transferase, family 2 H1Q60_RS16720 ENOG4105D8G Major Facilitator superfamily H1Q60_RS16725 ENOG4108Y4K DNA-binding transcriptional activator H1Q60_RS16730 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) H1Q60_RS16735 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H1Q60_RS16745 ENOG4108W7F transporter, permease H1Q60_RS16750 ENOG4108JJB ABC transporter H1Q60_RS16755 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein H1Q60_RS16760 ENOG4105VRS hydrolase family 18 H1Q60_RS16770 ENOG4105CJW magnesium transporter H1Q60_RS16775 ENOG4105V75 Transcriptional regulator H1Q60_RS16800 ENOG4105DQE DNA ligase H1Q60_RS16805 ENOG4105FDF Could be involved in DNA repair (By similarity) H1Q60_RS16810 ENOG4107T5V SNARE associated Golgi H1Q60_RS16815 ENOG4107TS3 membrane protein, TerC H1Q60_RS16820 ENOG4108WZW RNA polymerase sigma H1Q60_RS16830 ENOG410681C small acid-soluble spore protein H1Q60_RS16840 ENOG4105D0M Protease HtpX homolog H1Q60_RS16850 ENOG410900G Protein of unknown function (DUF421) H1Q60_RS16860 ENOG4108TGC Acyltransferase H1Q60_RS16865 ENOG4105BZU Histidine kinase H1Q60_RS16870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H1Q60_RS16875 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) H1Q60_RS16885 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H1Q60_RS16895 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate H1Q60_RS16900 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) H1Q60_RS16905 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) H1Q60_RS16910 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) H1Q60_RS16920 ENOG4105BZU Histidine kinase H1Q60_RS16925 ENOG41090MY MarR family Transcriptional regulator H1Q60_RS16930 ENOG4105ER2 Ompa motb domain protein H1Q60_RS16935 ENOG4105E14 MotA TolQ exbB proton channel H1Q60_RS16945 ENOG4108K88 Membrane H1Q60_RS16955 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) H1Q60_RS16960 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase H1Q60_RS16965 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H1Q60_RS16970 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) H1Q60_RS16980 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr H1Q60_RS17010 ENOG4105F0V Cell wall hydrolase H1Q60_RS17025 ENOG4105C59 p-type ATPase H1Q60_RS17030 ENOG4105DC7 peptidase M24 H1Q60_RS17040 ENOG4105CID antiterminator H1Q60_RS17050 ENOG4105KRI phosphocarrier protein (HPr H1Q60_RS17055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H1Q60_RS17065 ENOG4105F6S Spore photoproduct lyase H1Q60_RS17070 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer H1Q60_RS17075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H1Q60_RS17090 ENOG4105K4I Scp-like extracellular H1Q60_RS17100 ENOG4105BZU Histidine kinase H1Q60_RS17105 ENOG4105CHM Aminotransferase H1Q60_RS17115 ENOG4107R88 Chemotaxis protein (CheV) H1Q60_RS17120 ENOG4105UIN H1Q60_RS17130 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein H1Q60_RS17140 ENOG4105K6S Short-chain dehydrogenase reductase Sdr H1Q60_RS17150 ENOG4105EPM Diguanylate phosphodiesterase H1Q60_RS17155 ENOG4107IN1 Protein of unknown function (DUF1797) H1Q60_RS17160 ENOG4108XRC Protein of unknown function (DUF458) H1Q60_RS17190 ENOG4105NQC Flavodoxin H1Q60_RS17210 ENOG4105D8X mechanosensitive ion channel H1Q60_RS17215 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H1Q60_RS17230 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H1Q60_RS17235 ENOG4105D06 uba thif-type nad fad binding protein H1Q60_RS17240 ENOG4105CVM Molybdenum cofactor synthesis domain protein H1Q60_RS17245 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein H1Q60_RS17250 ENOG4108ZAF Molybdopterin H1Q60_RS17255 ENOG41067WU Molybdopterin converting factor (Subunit 1) H1Q60_RS17265 ENOG4107X8C Efflux transporter RND family MFP subunit H1Q60_RS17270 ENOG4105C19 ABC transporter H1Q60_RS17275 ENOG4107RBB ABC transporter, permease H1Q60_RS17280 ENOG4105E98 transcriptional regulator DeoR family H1Q60_RS17285 ENOG4105DE4 1-phosphofructokinase H1Q60_RS17290 ENOG4105DM4 PTS System H1Q60_RS17305 ENOG4105C5H ABC transporter H1Q60_RS17310 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H1Q60_RS17335 ENOG4105BZU Histidine kinase H1Q60_RS17345 ENOG4107ZYR domain protein H1Q60_RS17350 ENOG4105CPN adenine deaminase H1Q60_RS17355 ENOG4105CN5 Metallo-Beta-Lactamase H1Q60_RS17360 ENOG4106148 UPF0356 protein H1Q60_RS17365 ENOG4108X4Q Hydrolase H1Q60_RS17370 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H1Q60_RS17385 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H1Q60_RS17390 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS17395 ENOG4107SQU synthase H1Q60_RS17400 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS17405 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS17410 ENOG4107SQU synthase H1Q60_RS17415 ENOG4107SQU synthase H1Q60_RS17420 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS17425 ENOG4105FQP Beta-lactamase H1Q60_RS17435 ENOG4105CPP Dehydrogenase, E1 component H1Q60_RS17440 ENOG4105C7S Dehydrogenase H1Q60_RS17445 ENOG4107QN2 dihydrolipoyl dehydrogenase H1Q60_RS17465 ENOG4105CXN decarboxylase H1Q60_RS17470 ENOG4105WBI UPF0223 protein H1Q60_RS17485 ENOG4105ECY inositol monophosphatase H1Q60_RS17495 ENOG4105D4Y metalloprotease H1Q60_RS17530 ENOG4105CI3 gtp-binding protein typa H1Q60_RS17535 ENOG4105QA2 H1Q60_RS17550 ENOG4108IAB Phoh family H1Q60_RS17670 ENOG4105E4C Lytic transglycosylase catalytic H1Q60_RS17725 ENOG41068G1 H1Q60_RS17740 ENOG4105ZUG H1Q60_RS17750 ENOG4107D0N H1Q60_RS17805 ENOG4105CSV Glutaminase H1Q60_RS17815 ENOG4105CNI cell division protein FtsW H1Q60_RS17820 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) H1Q60_RS17830 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H1Q60_RS17840 ENOG4105BZ9 Cytochrome C oxidase, subunit I H1Q60_RS17845 ENOG4105CCU oxidase (Subunit III) H1Q60_RS17850 ENOG41064X9 cytochrome C oxidase subunit IV H1Q60_RS17865 ENOG41080XQ Signal transduction protein with cbs domains H1Q60_RS17870 ENOG4106UY4 Inherit from COG: Scp-like extracellular H1Q60_RS17895 ENOG4106H78 methyltransferase H1Q60_RS17900 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H1Q60_RS17905 ENOG4105H20 Sporulation integral membrane protein YlbJ H1Q60_RS17910 ENOG4105D78 K07001 NTE family protein H1Q60_RS17915 ENOG41063PX domain protein H1Q60_RS17920 ENOG4105CDE UPF0348 protein H1Q60_RS17925 ENOG4105KNH Nucleic acid-binding protein H1Q60_RS17955 ENOG4108V6E Cell division protein mraZ H1Q60_RS17960 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H1Q60_RS17970 ENOG4105CJN penicillin-binding protein H1Q60_RS17975 ENOG4105CJN penicillin-binding protein H1Q60_RS17980 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H1Q60_RS17985 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H1Q60_RS17990 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H1Q60_RS17995 ENOG4105CNI cell division protein FtsW H1Q60_RS18000 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H1Q60_RS18005 ENOG4105D4A Cell wall formation (By similarity) H1Q60_RS18010 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) H1Q60_RS18015 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H1Q60_RS18020 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H1Q60_RS18030 ENOG4105FFI sigma-e processing peptidase spoiiga H1Q60_RS18035 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS18045 ENOG4105DKW ABC transporter H1Q60_RS18055 ENOG4105WR5 sporulation protein, YlmC YmxH family H1Q60_RS18060 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H1Q60_RS18065 ENOG4105DFA alanine racemase domain protein H1Q60_RS18070 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) H1Q60_RS18075 ENOG41067XK integral membrane protein H1Q60_RS18080 ENOG4105DBK s4 domain protein H1Q60_RS18090 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H1Q60_RS18100 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H1Q60_RS18105 ENOG4105C34 Pseudouridine synthase H1Q60_RS18110 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H1Q60_RS18120 ENOG4105CXT aspartate transcarbamylase H1Q60_RS18130 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H1Q60_RS18135 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H1Q60_RS18140 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) H1Q60_RS18145 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) H1Q60_RS18150 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) H1Q60_RS18155 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H1Q60_RS18170 ENOG4107RIQ Sulfate adenylate transferase H1Q60_RS18180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) H1Q60_RS18185 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein H1Q60_RS18190 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein H1Q60_RS18210 ENOG4105DSJ YicC domain protein H1Q60_RS18215 ENOG4105KC4 UPF0296 protein H1Q60_RS18220 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H1Q60_RS18230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H1Q60_RS18235 ENOG4105C25 Primosomal protein n' H1Q60_RS18240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H1Q60_RS18245 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H1Q60_RS18250 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B H1Q60_RS18255 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H1Q60_RS18260 ENOG4108ZF3 Phosphatase H1Q60_RS18265 ENOG4105D9P serine threonine protein kinase H1Q60_RS18270 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H1Q60_RS18275 ENOG4105DJV ribulose-phosphate 3-epimerase H1Q60_RS18280 ENOG4105FJ0 thiamine H1Q60_RS18290 ENOG4105VB9 50S ribosomal protein l28 H1Q60_RS18295 ENOG4108ZAA Alkaline-shock protein H1Q60_RS18300 ENOG4105DP4 dak2 domain fusion protein ylov H1Q60_RS18310 ENOG4105EJQ L-serine dehydratase H1Q60_RS18315 ENOG4105CB5 ATP-dependent DNA helicase recG H1Q60_RS18320 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) H1Q60_RS18325 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) H1Q60_RS18330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H1Q60_RS18335 ENOG4105CHR reductase H1Q60_RS18345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H1Q60_RS18350 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) H1Q60_RS18355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H1Q60_RS18365 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) H1Q60_RS18375 ENOG4105K5M 30s ribosomal protein S16 H1Q60_RS18380 ENOG4108BW8 UPF0109 protein H1Q60_RS18395 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H1Q60_RS18400 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H1Q60_RS18405 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) H1Q60_RS18410 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H1Q60_RS18420 ENOG4105VM1 flagellar H1Q60_RS18425 ENOG4105CMV Succinyl-CoA synthetase subunit beta H1Q60_RS18430 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H1Q60_RS18435 ENOG4105C79 DNA protecting protein DprA H1Q60_RS18440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H1Q60_RS18445 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) H1Q60_RS18450 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H1Q60_RS18455 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) H1Q60_RS18460 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) H1Q60_RS18470 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H1Q60_RS18475 ENOG4108ZC9 flagellar basal-body rod protein flgc H1Q60_RS18480 ENOG4105VQ0 flagellar hook-basal body complex protein fliE H1Q60_RS18485 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H1Q60_RS18490 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H1Q60_RS18505 ENOG4106YF4 Flagellar biosynthesis chaperone H1Q60_RS18515 ENOG410696Y Flagellar hook-length control protein H1Q60_RS18520 ENOG410822I Flagellar hook capping protein H1Q60_RS18525 ENOG4108JQA flagellar H1Q60_RS18530 ENOG41068WV flagellar FlbD family protein H1Q60_RS18540 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H1Q60_RS18545 ENOG4105DD5 Flagellar motor switch protein H1Q60_RS18550 ENOG4107YTP response regulator receiver protein H1Q60_RS18560 ENOG4105CN7 Flagellar biosynthetic protein FliP H1Q60_RS18565 ENOG4105VS8 Flagellar biosynthetic protein fliq H1Q60_RS18570 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H1Q60_RS18575 ENOG4105D00 flagellar biosynthetic protein flhB H1Q60_RS18580 ENOG4105D7B Flagellar biosynthesis protein flha H1Q60_RS18585 ENOG4105FZW flagellar biosynthesis regulator FlhF H1Q60_RS18595 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) H1Q60_RS18600 ENOG4105CBS Chea signal transduction histidine kinase H1Q60_RS18605 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis H1Q60_RS18615 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) H1Q60_RS18620 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H1Q60_RS18630 ENOG4105CE9 30S ribosomal protein S2 H1Q60_RS18640 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H1Q60_RS18645 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H1Q60_RS18650 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H1Q60_RS18655 ENOG4105KNE Phosphatidate cytidylyltransferase H1Q60_RS18665 ENOG4105DZP Membrane-associated zinc metalloprotease H1Q60_RS18670 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) H1Q60_RS18675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H1Q60_RS18680 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) H1Q60_RS18685 ENOG4105CHV Transcription elongation factor NusA H1Q60_RS18690 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination H1Q60_RS18695 ENOG4105VHM ribosomal protein H1Q60_RS18700 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H1Q60_RS18705 ENOG4105W7A Protein of unknown function (DUF503) H1Q60_RS18710 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H1Q60_RS18715 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H1Q60_RS18720 ENOG4105DTN riboflavin biosynthesis protein ribF H1Q60_RS18725 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H1Q60_RS18730 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H1Q60_RS18740 ENOG4105C1V Peptidase, M16 H1Q60_RS18750 ENOG4105E35 Dipicolinate synthase subunit A H1Q60_RS18755 ENOG4108S0H Dipicolinic acid synthetase, b subunit H1Q60_RS18760 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H1Q60_RS18770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H1Q60_RS18780 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit H1Q60_RS18790 ENOG4105CNU cell division protein FtsK H1Q60_RS18795 ENOG4105FDP GntR family transcriptional regulator H1Q60_RS18810 ENOG4105EYF MMPL domain protein H1Q60_RS18825 ENOG4108RKS Short-chain dehydrogenase reductase Sdr H1Q60_RS18830 ENOG4105XZV Protein of unknown function (DUF3243) H1Q60_RS18845 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase H1Q60_RS18850 ENOG4105CEV competence damage-inducible protein H1Q60_RS18855 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H1Q60_RS18860 ENOG4108A04 Beta-lactamase H1Q60_RS18870 ENOG4105D48 metallophosphoesterase H1Q60_RS18875 ENOG4105MCT stage V sporulation protein S H1Q60_RS18880 ENOG4105CPQ Dehydrogenase H1Q60_RS18885 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H1Q60_RS18890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H1Q60_RS18910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H1Q60_RS18935 ENOG4108151 Beta-lactamase domain protein H1Q60_RS18945 ENOG4108JA1 polyketide synthase H1Q60_RS18950 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H1Q60_RS18955 ENOG41062T2 Acyl carrier protein H1Q60_RS18960 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase H1Q60_RS18965 ENOG4108MGH Enoyl-CoA hydratase H1Q60_RS18995 ENOG4105C0W non-ribosomal peptide synthetase H1Q60_RS19005 ENOG4106A3M Cytochrome p-450 H1Q60_RS19010 ENOG4105WFK nuclease H1Q60_RS19015 ENOG4105XPP Protein of unknown function (DUF1275) H1Q60_RS19025 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H1Q60_RS19035 ENOG4105K7W phage-related replication protein H1Q60_RS19040 ENOG4108X3M OsmC Ohr family protein H1Q60_RS19065 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H1Q60_RS19090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Q60_RS19095 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Q60_RS19100 ENOG4105U6W MutT NUDIX family protein H1Q60_RS19105 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H1Q60_RS19110 ENOG4106F1P AAA ATPase, central domain protein H1Q60_RS19115 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H1Q60_RS19120 ENOG4105CXI aluminum resistance protein H1Q60_RS19125 ENOG4105KV4 Transcriptional regulator H1Q60_RS19130 ENOG4105C5F glutamine synthetase H1Q60_RS19135 ENOG4105VTR Integrase H1Q60_RS19150 ENOG4107Y9E nuclease H1Q60_RS19165 ENOG4106BHF H1Q60_RS19190 ENOG4108YTE sporulation protein YunB H1Q60_RS19200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H1Q60_RS19225 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase H1Q60_RS19250 ENOG4105E4C Lytic transglycosylase catalytic H1Q60_RS19300 ENOG41068G1 H1Q60_RS19415 ENOG4105K70 DNA-binding protein H1Q60_RS19420 ENOG4105ZUG H1Q60_RS19425 ENOG4105ZUG H1Q60_RS19450 ENOG4108NE4 H1Q60_RS19470 ENOG4105C4R Atp-dependent dna helicase H1Q60_RS19475 ENOG4108ZUE Phage regulatory protein rha H1Q60_RS19505 ENOG4107NTZ H1Q60_RS19510 ENOG4107NTZ H1Q60_RS19580 ENOG4107D0N H1Q60_RS19730 ENOG4108J9Q DNA ligase H1Q60_RS19735 ENOG4108RAV Conserved protein H1Q60_RS19760 ENOG4105K7W phage-related replication protein H1Q60_RS19840 ENOG4106210 phosphatase activity H1Q60_RS19925 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) H1Q60_RS19930 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H1Q60_RS19965 ENOG4106ITI Glutaredoxin H1Q60_RS19975 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H1Q60_RS19995 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H1Q60_RS20000 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H1Q60_RS20070 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) H1Q60_RS20085 ENOG4105CT4 transporter H1Q60_RS20090 ENOG4105DSG hydrolase family 43 H1Q60_RS20100 ENOG4105C93 Xylose Isomerase H1Q60_RS20105 ENOG4105CMG Carbohydrate kinase H1Q60_RS20110 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H1Q60_RS20130 ENOG4105D29 Helix-turn-helix type 11 domain protein H1Q60_RS20140 ENOG4105DQ4 alcohol dehydrogenase H1Q60_RS20165 ENOG4106BHF H1Q60_RS20170 ENOG4106ANW SMI1_KNR4 H1Q60_RS20225 ENOG4108M1A Chitin-binding protein H1Q60_RS20250 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H1Q60_RS20255 ENOG4105K7W phage-related replication protein H1Q60_RS20280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) H1Q60_RS20290 ENOG4108SVB resolvase H1Q60_RS20295 ENOG4105VPS UPF0291 protein H1Q60_RS20300 ENOG4105CV1 Transketolase (EC 2.2.1.1) H1Q60_RS20310 ENOG4105VXM UPF0154 protein H1Q60_RS20320 ENOG4107QIV Cytochrome c biogenesis protein H1Q60_RS20355 ENOG4108I0Z Aconitate hydratase H1Q60_RS20360 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H1Q60_RS20375 ENOG41067CD Small, acid-soluble spore protein Tlp H1Q60_RS20385 ENOG4105MI2 H1Q60_RS20390 ENOG4105W8X HesB YadR YfhF-family protein H1Q60_RS20395 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) H1Q60_RS20400 ENOG4105K4P CoA-binding domain protein H1Q60_RS20405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H1Q60_RS20420 ENOG4108I5G Major Facilitator superfamily H1Q60_RS20435 ENOG4105FVX H1Q60_RS20475 ENOG4105DTD Dehydrogenase H1Q60_RS20480 ENOG4108IIH CoA-transferase subunit B H1Q60_RS20485 ENOG4105D6N CoA-transferase, subunit a H1Q60_RS20490 ENOG4105CY2 Citrate transporter H1Q60_RS20495 ENOG4106A3M Cytochrome p-450 H1Q60_RS20500 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H1Q60_RS20505 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H1Q60_RS20510 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H1Q60_RS20515 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Q60_RS20520 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) H1Q60_RS20530 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H1Q60_RS20535 ENOG4107T5V SNARE associated Golgi H1Q60_RS20540 ENOG4107QX3 carboxylase H1Q60_RS20545 ENOG4105E39 Enoyl-CoA hydratase H1Q60_RS20550 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase H1Q60_RS20555 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit H1Q60_RS20560 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H1Q60_RS20565 ENOG4105CEY Amp-dependent synthetase and ligase H1Q60_RS20570 ENOG4105C1G acyl-Coa dehydrogenase H1Q60_RS20575 ENOG4105F32 YngK protein H1Q60_RS20580 ENOG4106U2H Protein of unknown function (DUF1360) H1Q60_RS20600 ENOG4105H67 Protein of unknown function (DUF421) H1Q60_RS20605 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) H1Q60_RS20615 ENOG4108QY0 Membrane H1Q60_RS20630 ENOG4105CZ3 stage V sporulation protein ad H1Q60_RS20635 ENOG41090VF Stage v sporulation protein ac H1Q60_RS20675 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family H1Q60_RS20680 ENOG4108N2V aldose 1-epimerase H1Q60_RS20685 ENOG4107QJQ Mate efflux family protein H1Q60_RS20710 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H1Q60_RS20720 ENOG4105WAB arsR family transcriptional regulator H1Q60_RS20725 ENOG4105C22 threonyL-tRNA synthetase H1Q60_RS20730 ENOG4108KSA LysR family transcriptional regulator H1Q60_RS20735 ENOG4105CB2 alcohol dehydrogenase H1Q60_RS20745 ENOG4105BZ8 glutamate synthase H1Q60_RS20750 ENOG4105CBC glutamate synthase H1Q60_RS20755 ENOG4105C5Q Transcriptional regulator H1Q60_RS20760 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) H1Q60_RS20785 ENOG4108UB7 H1Q60_RS20790 ENOG4105IE8 Alpha-ketoglutarate permease H1Q60_RS20795 ENOG4107U6E carbohydrate kinase FGGY H1Q60_RS20805 ENOG4108J2R molybdopterin oxidoreductase H1Q60_RS20835 ENOG4106ANW SMI1_KNR4 H1Q60_RS20840 ENOG4106BHF H1Q60_RS20845 ENOG4108Z7R Chaperone CsaA H1Q60_RS20850 ENOG4105FTV AraC Family Transcriptional Regulator H1Q60_RS20860 ENOG4108W8B Beta-lactamase domain protein H1Q60_RS20870 ENOG4105KTU Transcriptional regulator, arsr family H1Q60_RS20880 ENOG4108SJC Membrane H1Q60_RS20905 ENOG41069ER domain protein H1Q60_RS20910 ENOG4105C9U ATP-dependent DNA helicase RecQ H1Q60_RS20920 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) H1Q60_RS20925 ENOG4105SCY DNAK suppressor H1Q60_RS20970 ENOG4105C26 Dehydrogenase H1Q60_RS20975 ENOG4105EWU Squalene--hopene cyclase H1Q60_RS20980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H1Q60_RS20985 ENOG4105C8J )-transporter H1Q60_RS20990 ENOG4105C09 Bile acid H1Q60_RS21000 ENOG4105C7S Dehydrogenase H1Q60_RS21005 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H1Q60_RS21010 ENOG4107T89 von Willebrand factor, type A H1Q60_RS21015 ENOG4105GMT ATPase associated with various cellular activities aaa_5 H1Q60_RS21025 ENOG4105K4H Nlp p60 protein H1Q60_RS21030 ENOG41087PP glycosyltransferase MGT family H1Q60_RS21040 ENOG4107QMU Mate efflux family protein H1Q60_RS21045 ENOG4106SCS STAS domain H1Q60_RS21065 ENOG4105FR1 rard protein H1Q60_RS21080 ENOG41090U3 tautomerase H1Q60_RS21115 ENOG4105E1V na solute symporter H1Q60_RS21130 ENOG4108S3Y transcriptional regulator H1Q60_RS21150 ENOG4108VXD carboxy-peptidase H1Q60_RS21155 ENOG4105D3A purine nucleoside phosphorylase DeoD-type H1Q60_RS21165 ENOG4106Z5R H1Q60_RS21170 ENOG410841Q phosphoesterase PA-phosphatase related protein H1Q60_RS21200 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H1Q60_RS21205 ENOG4108TSC N-acetyltransferase H1Q60_RS21210 ENOG4107S4Y M20 DapE family protein YgeY H1Q60_RS21225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H1Q60_RS21230 ENOG4105FTQ Dna gyrase