locus-tag	class	description
CS376_RS00010	COG0592	DNA-directed DNA polymerase activity
CS376_RS00015	COG2501	S4 domain
CS376_RS00030	COG0187	DNA topoisomerase II activity
CS376_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS376_RS00070	COG0517	IMP dehydrogenase activity
CS376_RS00070	COG0516	GMP reductase activity
CS376_RS00075	COG1686	Belongs to the peptidase S11 family
CS376_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
CS376_RS00105	COG1428	Deoxynucleoside kinase
CS376_RS00110	COG1428	Deoxynucleoside kinase
CS376_RS00115	COG3858	chitin binding
CS376_RS00115	COG1388	LysM domain
CS376_RS00120	COG1335	isochorismatase
CS376_RS00125	COG0590	tRNA wobble adenosine to inosine editing
CS376_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS376_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CS376_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CS376_RS00195	COG3853	Toxic anion resistance protein (TelA)
CS376_RS00200	COG1982	Orn Lys Arg decarboxylase major
CS376_RS00210	COG3870	Protein conserved in bacteria
CS376_RS00215	COG1728	Protein conserved in bacteria
CS376_RS00220	COG0470	DNA polymerase III
CS376_RS00225	COG1774	PSP1 C-terminal conserved region
CS376_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CS376_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS376_RS00250	COG2002	toxin-antitoxin pair type II binding
CS376_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS376_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS376_RS00260	COG0084	hydrolase, TatD family'
CS376_RS00265	COG3583	domain protein
CS376_RS00265	COG3584	3D domain protein
CS376_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CS376_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS376_RS00285	COG4466	Protein conserved in bacteria
CS376_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS376_RS00305	COG0251	oxidation-reduction process
CS376_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS376_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS376_RS00345	COG2002	toxin-antitoxin pair type II binding
CS376_RS00350	COG2244	polysaccharide biosynthetic process
CS376_RS00355	COG3956	TIGRFAM MazG family protein
CS376_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS376_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CS376_RS00380	COG1098	S1 RNA binding domain
CS376_RS00395	COG2208	phosphoserine phosphatase activity
CS376_RS00400	COG2304	oxidoreductase activity
CS376_RS00405	COG0515	serine threonine protein kinase
CS376_RS00410	COG0037	tRNA processing
CS376_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CS376_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS376_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS376_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS376_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS376_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
CS376_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS376_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS376_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CS376_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS376_RS00475	COG1396	sequence-specific DNA binding
CS376_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CS376_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS376_RS00570	COG4463	regulation of RNA biosynthetic process
CS376_RS00575	COG3880	PFAM UvrB UvrC protein
CS376_RS00585	COG0542	response to heat
CS376_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CS376_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CS376_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
CS376_RS00620	COG1045	serine acetyltransferase
CS376_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CS376_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS376_RS00640	COG3688	RNA-binding protein containing a PIN domain
CS376_RS00645	COG1595	DNA-templated transcription, initiation
CS376_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS376_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
CS376_RS00685	COG2813	Specifically methylates the guanine in position
CS376_RS00700	COG1358	cellular component organization or biogenesis
CS376_RS00725	COG0596	Alpha beta hydrolase
CS376_RS00835	COG0201	protein transport
CS376_RS00845	COG0024	Methionine aminopeptidase
CS376_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CS376_RS00885	COG1122	ATPase activity
CS376_RS00890	COG1122	ATPase activity
CS376_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CS376_RS00915	COG2226	methyltransferase
CS376_RS00920	COG2318	DinB family
CS376_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS376_RS00935	COG0489	protein tyrosine kinase activity
CS376_RS00945	COG2194	sulfuric ester hydrolase activity
CS376_RS00950	COG0726	polysaccharide deacetylase
CS376_RS01010	COG0738	Major facilitator superfamily
CS376_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS376_RS01030	COG0659	secondary active sulfate transmembrane transporter activity
CS376_RS01035	COG0385	Bile acid
CS376_RS01040	COG2819	hydrolase of the alpha beta superfamily
CS376_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS376_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS376_RS01060	COG2207	Transcriptional regulator
CS376_RS01065	COG3876	Protein conserved in bacteria
CS376_RS01070	COG1472	Belongs to the glycosyl hydrolase 3 family
CS376_RS01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS376_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS01080	COG1263	PTS System
CS376_RS01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS376_RS01095	COG1683	Conserved Protein
CS376_RS01125	COG1595	DNA-templated transcription, initiation
CS376_RS01130	COG5662	AntiSigma factor
CS376_RS01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS376_RS01140	COG4856	YbbR-like protein
CS376_RS01175	COG2205	protein histidine kinase activity
CS376_RS01180	COG1136	(ABC) transporter
CS376_RS01185	COG0577	efflux transmembrane transporter activity
CS376_RS01205	COG1346	cytolysis
CS376_RS01210	COG1380	Effector of murein hydrolase LrgA
CS376_RS01215	COG1846	Transcriptional regulator
CS376_RS01220	COG1113	amino acid transport
CS376_RS01225	COG1011	Hydrolase
CS376_RS01230	COG4585	Histidine kinase
CS376_RS01235	COG2197	response regulator
CS376_RS01240	COG1131	(ABC) transporter
CS376_RS01280	COG0531	amino acid
CS376_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
CS376_RS01300	COG2271	Major facilitator Superfamily
CS376_RS01315	COG2368	4-hydroxyphenylacetate
CS376_RS01325	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS01340	COG0371	Dehydrogenase
CS376_RS01350	COG1183	phosphatidylcholine synthase activity
CS376_RS01355	COG0586	Pfam SNARE associated Golgi protein
CS376_RS01360	COG0688	phosphatidylethanolamine metabolic process
CS376_RS01375	COG1301	dicarboxylic acid transport
CS376_RS01380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS376_RS01385	COG0833	amino acid
CS376_RS01390	COG2040	homocysteine
CS376_RS01395	COG1115	amino acid carrier protein
CS376_RS01400	COG2066	Belongs to the glutaminase family
CS376_RS01405	COG4191	Histidine kinase
CS376_RS01410	COG0784	Response regulator, receiver
CS376_RS01415	COG3173	Aminoglycoside phosphotransferase
CS376_RS01430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS376_RS01435	COG0778	Nitroreductase
CS376_RS01440	COG0346	lactoylglutathione lyase activity
CS376_RS01445	COG2259	Doxx family
CS376_RS01450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS01465	COG3773	Cell wall hydrolase
CS376_RS01475	COG3540	Alkaline phosphatase
CS376_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS376_RS01485	COG0805	protein transport
CS376_RS01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS376_RS01500	COG0477	Major facilitator Superfamily
CS376_RS01505	COG1309	transcriptional regulator
CS376_RS01510	COG0252	asparaginase activity
CS376_RS01515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CS376_RS01520	COG1405	negative regulation of cell septum assembly
CS376_RS01520	COG3012	SEC-C Motif Domain Protein
CS376_RS01525	COG0667	Aldo Keto reductase
CS376_RS01535	COG1595	DNA-templated transcription, initiation
CS376_RS01540	COG1595	DNA-templated transcription, initiation
CS376_RS01545	COG1876	peptidase activity
CS376_RS01550	COG0457	Tetratricopeptide repeat
CS376_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS01560	COG0366	Alpha amylase catalytic
CS376_RS01565	COG0803	Belongs to the bacterial solute-binding protein 9 family
CS376_RS01570	COG1121	(ABC) transporter
CS376_RS01575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS376_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS01585	COG2310	stress, protein
CS376_RS01590	COG2310	stress, protein
CS376_RS01595	COG2310	stress, protein
CS376_RS01600	COG0861	Integral membrane protein TerC family
CS376_RS01610	COG3853	Toxic anion resistance protein (TelA)
CS376_RS01615	COG0477	Major facilitator Superfamily
CS376_RS01620	COG4175	Glycine betaine
CS376_RS01620	COG0517	IMP dehydrogenase activity
CS376_RS01625	COG4176	ABC-type proline glycine betaine transport system permease component
CS376_RS01630	COG2113	Glycine betaine
CS376_RS01635	COG1473	amidohydrolase
CS376_RS01640	COG1288	antiporter activity
CS376_RS01650	COG0366	Alpha amylase catalytic
CS376_RS01725	COG2814	Major facilitator Superfamily
CS376_RS01730	COG1846	Transcriptional regulator
CS376_RS01735	COG1280	lysine exporter protein (LysE YggA)
CS376_RS01740	COG3403	YqcI/YcgG family
CS376_RS01745	COG1113	amino acid transport
CS376_RS01750	COG3665	Urea carboxylase-associated protein
CS376_RS01765	COG1082	Xylose isomerase domain protein TIM barrel
CS376_RS01770	COG2271	Major facilitator Superfamily
CS376_RS01775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS376_RS01780	COG3458	cephalosporin-C deacetylase activity
CS376_RS01785	COG3541	Predicted nucleotidyltransferase
CS376_RS01790	COG0506	proline dehydrogenase activity
CS376_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS01800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS376_RS01805	COG2508	Transcriptional regulator
CS376_RS01815	COG1587	Uroporphyrinogen-III synthase
CS376_RS01815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CS376_RS01820	COG2146	nitrite reductase [NAD(P)H] activity
CS376_RS01825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS376_RS01830	COG0243	molybdopterin cofactor binding
CS376_RS01835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS376_RS01840	COG2223	nitrite transmembrane transporter activity
CS376_RS01845	COG0523	cobalamin synthesis protein
CS376_RS01850	COG1063	alcohol dehydrogenase
CS376_RS01855	COG1714	RDD family
CS376_RS01865	COG2723	6-phospho-beta-galactosidase activity
CS376_RS01875	COG3209	COG3209 Rhs family protein
CS376_RS01880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS376_RS01885	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CS376_RS01890	COG1733	regulation of RNA biosynthetic process
CS376_RS01900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS01905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS01910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS01915	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CS376_RS01930	COG0697	spore germination
CS376_RS01935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS01945	COG2364	Membrane
CS376_RS01950	COG1126	abc transporter atp-binding protein
CS376_RS01955	COG0765	amino acid transport
CS376_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS01965	COG0583	DNA-binding transcription factor activity
CS376_RS01970	COG0163	prenyltransferase activity
CS376_RS01975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CS376_RS01990	COG3104	oligopeptide transport
CS376_RS01995	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS02005	COG0697	spore germination
CS376_RS02015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS376_RS02020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS02025	COG0456	acetyltransferase
CS376_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS02035	COG0765	amino acid transport
CS376_RS02040	COG1126	abc transporter atp-binding protein
CS376_RS02045	COG1473	amidohydrolase
CS376_RS02050	COG2079	MmgE PrpD family protein
CS376_RS02055	COG1136	(ABC) transporter
CS376_RS02060	COG0577	efflux transmembrane transporter activity
CS376_RS02065	COG0745	RESPONSE REGULATOR receiver
CS376_RS02070	COG5002	protein histidine kinase activity
CS376_RS02070	COG3850	Histidine kinase
CS376_RS02090	COG0527	aspartate kinase activity
CS376_RS02095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS02100	COG4605	iron ion homeostasis
CS376_RS02105	COG4604	ABC transporter, ATP-binding protein
CS376_RS02110	COG4607	ABC-type enterochelin transport system periplasmic component
CS376_RS02115	COG2814	Major facilitator Superfamily
CS376_RS02120	COG1309	transcriptional regulator
CS376_RS02125	COG0778	Nitroreductase
CS376_RS02130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CS376_RS02135	COG0640	Transcriptional regulator
CS376_RS02140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS02145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS376_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS02155	COG4975	Glucose uptake
CS376_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS02165	COG4549	nuclear export factor GLE1
CS376_RS02170	COG2372	response to copper ion
CS376_RS02170	COG1276	copper resistance
CS376_RS02175	COG1349	DNA-binding transcription factor activity
CS376_RS02185	COG2213	PTS system mannitol-specific
CS376_RS02190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS02200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CS376_RS02210	COG0561	phosphatase activity
CS376_RS02220	COG1914	H( )-stimulated, divalent metal cation uptake system
CS376_RS02230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS376_RS02235	COG1984	allophanate hydrolase subunit 2
CS376_RS02240	COG1414	Transcriptional regulator
CS376_RS02245	COG2755	lipolytic protein G-D-S-L family
CS376_RS02255	COG2329	Antibiotic biosynthesis monooxygenase
CS376_RS02260	COG0768	penicillin binding
CS376_RS02265	COG4989	oxidoreductase activity
CS376_RS02270	COG3711	transcriptional antiterminator
CS376_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS02280	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS02285	COG1917	Cupin 2, conserved barrel domain protein
CS376_RS02290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS376_RS02305	COG2814	Major facilitator Superfamily
CS376_RS02310	COG1522	sequence-specific DNA binding
CS376_RS02315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS376_RS02315	COG0551	DNA topoisomerase type I activity
CS376_RS02320	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CS376_RS02325	COG3706	GGDEF domain
CS376_RS02330	COG5298	Protein conserved in bacteria
CS376_RS02335	COG1215	transferase activity, transferring glycosyl groups
CS376_RS02345	COG0531	amino acid
CS376_RS02350	COG0494	nUDIX hydrolase
CS376_RS02355	COG0028	Belongs to the TPP enzyme family
CS376_RS02385	COG1914	H( )-stimulated, divalent metal cation uptake system
CS376_RS02400	COG4876	unkown
CS376_RS02410	COG2076	Multidrug Resistance protein
CS376_RS02415	COG2217	Heavy metal translocating P-type atpase
CS376_RS02420	COG3729	General stress protein
CS376_RS02425	COG0662	Cupin 2, conserved barrel domain protein
CS376_RS02430	COG2329	Antibiotic biosynthesis monooxygenase
CS376_RS02435	COG3546	catalase activity
CS376_RS02440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CS376_RS02445	COG3290	protein histidine kinase activity
CS376_RS02450	COG4565	transcriptional regulatory protein
CS376_RS02455	COG1301	dicarboxylic acid transport
CS376_RS02460	COG0628	permease
CS376_RS02465	COG1131	(ABC) transporter
CS376_RS02470	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS376_RS02480	COG1960	acyl-CoA dehydrogenase activity
CS376_RS02495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS376_RS02500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS02510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS376_RS02515	COG0513	Belongs to the DEAD box helicase family
CS376_RS02520	COG3402	PFAM membrane-flanked domain
CS376_RS02525	COG3428	Bacterial PH domain
CS376_RS02530	COG0705	Rhomboid family
CS376_RS02540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CS376_RS02545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS376_RS02550	COG0864	Transcriptional regulator
CS376_RS02555	COG2337	Toxic component of a toxin-antitoxin (TA) module
CS376_RS02560	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS02565	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS02570	COG2172	sigma factor antagonist activity
CS376_RS02575	COG2208	phosphoserine phosphatase activity
CS376_RS02580	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS02590	COG1191	sigma factor activity
CS376_RS02595	COG2208	phosphoserine phosphatase activity
CS376_RS02600	COG2183	response to ionizing radiation
CS376_RS02670	COG0604	alcohol dehydrogenase
CS376_RS02680	COG1959	2 iron, 2 sulfur cluster binding
CS376_RS02685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS376_RS02690	COG1090	epimerase
CS376_RS02695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS376_RS02710	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS376_RS02735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CS376_RS02740	COG0477	Major facilitator Superfamily
CS376_RS02745	COG1846	Transcriptional regulator
CS376_RS02755	COG2030	dehydratase
CS376_RS02770	COG1959	2 iron, 2 sulfur cluster binding
CS376_RS02775	COG2910	NAD(P)H-binding
CS376_RS02780	COG1309	transcriptional regulator
CS376_RS02785	COG0300	oxidoreductase activity
CS376_RS02795	COG0604	alcohol dehydrogenase
CS376_RS02805	COG3239	Fatty acid desaturase
CS376_RS02810	COG1278	Cold shock
CS376_RS02815	COG1329	Transcriptional regulator
CS376_RS02820	COG1937	Protein conserved in bacteria
CS376_RS02825	COG2210	Belongs to the sulfur carrier protein TusA family
CS376_RS02835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS376_RS02835	COG0425	Belongs to the sulfur carrier protein TusA family
CS376_RS02840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS02840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS376_RS02845	COG0425	Belongs to the sulfur carrier protein TusA family
CS376_RS02850	COG0730	response to heat
CS376_RS02855	COG1794	racemase activity, acting on amino acids and derivatives
CS376_RS02870	COG1846	Transcriptional regulator
CS376_RS02870	COG0456	acetyltransferase
CS376_RS02875	COG2271	Major facilitator Superfamily
CS376_RS02880	COG3621	Patatin-like phospholipase
CS376_RS02890	COG0662	Cupin 2, conserved barrel domain protein
CS376_RS02905	COG0277	FAD linked oxidase domain protein
CS376_RS02930	COG0662	Cupin 2, conserved barrel domain protein
CS376_RS02935	COG2318	DinB family
CS376_RS02940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS376_RS02965	COG1064	alcohol dehydrogenase
CS376_RS02970	COG0789	Transcriptional regulator
CS376_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS03015	COG2814	Major facilitator Superfamily
CS376_RS03020	COG1309	transcriptional regulator
CS376_RS03025	COG0697	spore germination
CS376_RS03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS03035	COG5577	PFAM Coat F domain
CS376_RS03045	COG1063	alcohol dehydrogenase
CS376_RS03050	COG5577	PFAM Coat F domain
CS376_RS03060	COG0738	Major facilitator superfamily
CS376_RS03070	COG0110	maltose O-acetyltransferase activity
CS376_RS03075	COG4585	Histidine kinase
CS376_RS03080	COG2197	response regulator
CS376_RS03085	COG2409	Drug exporters of the RND superfamily
CS376_RS03090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CS376_RS03095	COG0488	(ABC) transporter
CS376_RS03100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS376_RS03105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS03115	COG2814	Major facilitator Superfamily
CS376_RS03120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS376_RS03130	COG0730	response to heat
CS376_RS03135	COG0456	acetyltransferase
CS376_RS03140	COG0789	Transcriptional regulator
CS376_RS03140	COG4978	Transcriptional regulator
CS376_RS03145	COG0697	spore germination
CS376_RS03150	COG1051	belongs to the nudix hydrolase family
CS376_RS03155	COG2226	methyltransferase
CS376_RS03160	COG0473	3-isopropylmalate dehydrogenase activity
CS376_RS03165	COG1802	Transcriptional regulator
CS376_RS03170	COG1819	glycosyl
CS376_RS03185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS376_RS03190	COG1388	LysM domain
CS376_RS03195	COG2814	Major facilitator Superfamily
CS376_RS03200	COG2188	Transcriptional regulator
CS376_RS03205	COG2186	Transcriptional regulator
CS376_RS03210	COG2807	transmembrane transport
CS376_RS03215	COG2076	Multidrug Resistance protein
CS376_RS03220	COG2076	Multidrug Resistance protein
CS376_RS03225	COG1309	transcriptional regulator
CS376_RS03230	COG0531	amino acid
CS376_RS03240	COG3832	glyoxalase III activity
CS376_RS03245	COG0604	alcohol dehydrogenase
CS376_RS03250	COG2814	Major facilitator Superfamily
CS376_RS03290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CS376_RS03295	COG0802	atpase or kinase
CS376_RS03300	COG1214	PFAM Peptidase M22, glycoprotease
CS376_RS03305	COG0456	acetyltransferase
CS376_RS03310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CS376_RS03315	COG0488	(ABC) transporter
CS376_RS03330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS376_RS03335	COG0805	protein transport
CS376_RS03345	COG1266	CAAX protease self-immunity
CS376_RS03375	COG0457	Tetratricopeptide repeat
CS376_RS03380	COG1063	alcohol dehydrogenase
CS376_RS03385	COG2211	Major facilitator Superfamily
CS376_RS03390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS376_RS03400	COG1842	Phage shock protein A
CS376_RS03405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS376_RS03410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CS376_RS03415	COG4260	virion core protein, lumpy skin disease virus
CS376_RS03420	COG2755	lipolytic protein G-D-S-L family
CS376_RS03420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CS376_RS03430	COG1595	DNA-templated transcription, initiation
CS376_RS03435	COG1063	alcohol dehydrogenase
CS376_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CS376_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
CS376_RS03455	COG2132	Multicopper oxidase
CS376_RS03460	COG1113	amino acid transport
CS376_RS03465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS376_RS03470	COG0714	Associated with various cellular activities
CS376_RS03475	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CS376_RS03480	COG1305	Transglutaminase-like
CS376_RS03500	COG2252	PERMEase
CS376_RS03505	COG3064	Membrane
CS376_RS03525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CS376_RS03530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CS376_RS03535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CS376_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS376_RS03545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS376_RS03560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CS376_RS03570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CS376_RS03575	COG0138	bifunctional purine biosynthesis protein purh
CS376_RS03580	COG0151	Belongs to the GarS family
CS376_RS03590	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CS376_RS03595	COG1470	cell adhesion involved in biofilm formation
CS376_RS03600	COG4496	protein, YerC YecD
CS376_RS03605	COG0069	glutamate synthase activity
CS376_RS03620	COG0210	DNA helicase
CS376_RS03630	COG4851	CamS sex pheromone cAM373 precursor
CS376_RS03635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS376_RS03640	COG1285	pathogenesis
CS376_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS376_RS03665	COG1309	transcriptional regulator
CS376_RS03670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS376_RS03675	COG1597	lipid kinase activity
CS376_RS03680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS376_RS03690	COG1131	(ABC) transporter
CS376_RS03735	COG5444	nuclease activity
CS376_RS03760	COG3546	catalase activity
CS376_RS03765	COG0454	-acetyltransferase
CS376_RS03775	COG2323	membrane
CS376_RS03780	COG2329	Antibiotic biosynthesis monooxygenase
CS376_RS03785	COG0346	lactoylglutathione lyase activity
CS376_RS03795	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS03800	COG5583	Uncharacterized small protein (DUF2292)
CS376_RS03805	COG0196	riboflavin kinase activity
CS376_RS03810	COG0670	Belongs to the BI1 family
CS376_RS03815	COG1846	Transcriptional regulator
CS376_RS03820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CS376_RS03830	COG2124	cytochrome p450
CS376_RS03830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS376_RS03845	COG1131	(ABC) transporter
CS376_RS03860	COG1368	sulfuric ester hydrolase activity
CS376_RS03865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CS376_RS03870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS03875	COG1442	glycosyl transferase family 8
CS376_RS03880	COG1216	Glycosyl transferase, family 2
CS376_RS03885	COG1442	glycosyl transferase family 8
CS376_RS03890	COG2223	nitrite transmembrane transporter activity
CS376_RS03895	COG0531	amino acid
CS376_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS03905	COG0840	transmembrane signaling receptor activity
CS376_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS03915	COG0457	Tetratricopeptide repeat
CS376_RS03915	COG0463	Glycosyl transferase, family 2
CS376_RS03920	COG0488	(ABC) transporter
CS376_RS03925	COG0789	Transcriptional regulator
CS376_RS03930	COG2814	Major facilitator Superfamily
CS376_RS03935	COG0488	(ABC) transporter
CS376_RS03940	COG0513	Belongs to the DEAD box helicase family
CS376_RS03945	COG0456	acetyltransferase
CS376_RS03950	COG2130	NADP-dependent
CS376_RS03965	COG3866	Pectate lyase
CS376_RS03970	COG0471	metal ion transport
CS376_RS03990	COG2972	Histidine kinase
CS376_RS03990	COG0745	RESPONSE REGULATOR receiver
CS376_RS03995	COG3279	Response regulator of the LytR AlgR family
CS376_RS04005	COG3764	Sortase (surface protein transpeptidase)
CS376_RS04015	COG3290	protein histidine kinase activity
CS376_RS04020	COG4565	transcriptional regulatory protein
CS376_RS04025	COG3181	Tripartite tricarboxylate transporter family receptor
CS376_RS04030	COG2851	Citrate transporter
CS376_RS04035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS04040	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CS376_RS04050	COG2258	MOSC domain
CS376_RS04070	COG0024	Methionine aminopeptidase
CS376_RS04075	COG1263	PTS System
CS376_RS04075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS04085	COG1368	sulfuric ester hydrolase activity
CS376_RS04095	COG0071	Belongs to the small heat shock protein (HSP20) family
CS376_RS04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS04110	COG1263	PTS System
CS376_RS04115	COG0366	Alpha amylase catalytic
CS376_RS04120	COG2188	Transcriptional regulator
CS376_RS04125	COG0778	Nitroreductase
CS376_RS04140	COG0737	Belongs to the 5'-nucleotidase family
CS376_RS04145	COG0693	protein deglycase activity
CS376_RS04150	COG1609	Transcriptional regulator
CS376_RS04165	COG2814	Major facilitator Superfamily
CS376_RS04175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS376_RS04180	COG4980	gas vesicle protein
CS376_RS04185	COG1295	ribonuclease BN
CS376_RS04190	COG0477	Major facilitator Superfamily
CS376_RS04195	COG0387	Pfam Sodium calcium exchanger
CS376_RS04205	COG0668	transmembrane transport
CS376_RS04210	COG0535	radical SAM domain protein
CS376_RS04220	COG0726	polysaccharide deacetylase
CS376_RS04225	COG2084	Dehydrogenase
CS376_RS04235	COG0598	Magnesium transport protein CorA
CS376_RS04240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CS376_RS04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS376_RS04255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CS376_RS04265	COG4637	Psort location Cytoplasmic, score
CS376_RS04270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS376_RS04280	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS376_RS04285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS376_RS04290	COG3284	Transcriptional regulator
CS376_RS04300	COG1486	melibiose metabolic process
CS376_RS04305	COG1737	Transcriptional regulator
CS376_RS04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS04310	COG1263	PTS System
CS376_RS04315	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS04320	COG1132	(ABC) transporter
CS376_RS04325	COG1132	(ABC) transporter
CS376_RS04330	COG2259	Doxx family
CS376_RS04335	COG2514	catechol 2,3-dioxygenase activity
CS376_RS04350	COG1695	Transcriptional regulator
CS376_RS04355	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS376_RS04360	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CS376_RS04370	COG0574	Belongs to the PEP-utilizing enzyme family
CS376_RS04370	COG3848	Pyruvate phosphate dikinase
CS376_RS04375	COG2732	(Barnase) inhibitor
CS376_RS04380	COG2318	DinB family
CS376_RS04385	COG2814	Major facilitator Superfamily
CS376_RS04390	COG1846	Transcriptional regulator
CS376_RS04395	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CS376_RS04395	COG0392	lysyltransferase activity
CS376_RS04400	COG0384	phenazine biosynthesis protein PhzF
CS376_RS04405	COG0778	Nitroreductase
CS376_RS04420	COG1090	epimerase
CS376_RS04435	COG2814	Major facilitator Superfamily
CS376_RS04445	COG3591	Belongs to the peptidase S1B family
CS376_RS04460	COG3103	Sh3 type 3 domain protein
CS376_RS04465	COG5658	integral membrane protein
CS376_RS04470	COG0596	Alpha beta hydrolase
CS376_RS04475	COG0463	Glycosyl transferase, family 2
CS376_RS04480	COG4485	Bacterial membrane protein, YfhO
CS376_RS04485	COG1988	membrane-bound metal-dependent
CS376_RS04490	COG1194	a g-specific adenine glycosylase
CS376_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS04520	COG1132	(ABC) transporter
CS376_RS04525	COG4129	membrane
CS376_RS04535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS376_RS04540	COG0735	belongs to the Fur family
CS376_RS04655	COG1757	Na H antiporter
CS376_RS04660	COG3340	Belongs to the peptidase S51 family
CS376_RS04670	COG0277	FAD linked oxidase domain protein
CS376_RS04680	COG0747	negative chemotaxis
CS376_RS04685	COG0601	transmembrane transport
CS376_RS04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS376_RS04695	COG0444	Belongs to the ABC transporter superfamily
CS376_RS04700	COG4608	Belongs to the ABC transporter superfamily
CS376_RS04705	COG0753	catalase activity
CS376_RS04715	COG1116	anion transmembrane transporter activity
CS376_RS04720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS376_RS04725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS376_RS04745	COG1476	TRANSCRIPTIONal
CS376_RS04755	COG3382	B3 4 domain protein
CS376_RS04760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CS376_RS04770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CS376_RS04775	COG0789	Transcriptional regulator
CS376_RS04780	COG1664	Polymer-forming cytoskeletal
CS376_RS04785	COG1664	Polymer-forming cytoskeletal
CS376_RS04795	COG2766	serine protein kinase
CS376_RS04810	COG1846	Transcriptional regulator
CS376_RS04815	COG1566	PFAM secretion protein HlyD family protein
CS376_RS04820	COG2814	Major facilitator Superfamily
CS376_RS04825	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS376_RS04840	COG1725	Transcriptional regulator
CS376_RS04845	COG1131	(ABC) transporter
CS376_RS04850	COG1131	(ABC) transporter
CS376_RS04855	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS376_RS04860	COG1278	Cold shock
CS376_RS04870	COG1464	Belongs to the NlpA lipoprotein family
CS376_RS04875	COG3706	GGDEF domain
CS376_RS04880	COG1823	symporter activity
CS376_RS04900	COG5577	PFAM Coat F domain
CS376_RS04910	COG3764	Sortase (surface protein transpeptidase)
CS376_RS04915	COG0564	pseudouridine synthase activity
CS376_RS04925	COG0517	IMP dehydrogenase activity
CS376_RS04930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS376_RS04935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS376_RS04935	COG3153	acetyltransferase
CS376_RS04940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS376_RS04945	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CS376_RS04950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CS376_RS04960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CS376_RS04965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS376_RS04970	COG2203	Gaf domain
CS376_RS04970	COG4585	Histidine kinase
CS376_RS04975	COG2197	response regulator
CS376_RS04980	COG0431	NADPH-dependent FMN reductase
CS376_RS04995	COG1388	LysM domain
CS376_RS04995	COG0791	NLP P60 protein
CS376_RS05000	COG1959	2 iron, 2 sulfur cluster binding
CS376_RS05010	COG0668	transmembrane transport
CS376_RS05015	COG2719	SpoVR family
CS376_RS05020	COG1785	Belongs to the alkaline phosphatase family
CS376_RS05025	COG0791	NLP P60 protein
CS376_RS05025	COG1388	LysM domain
CS376_RS05035	COG0372	Belongs to the citrate synthase family
CS376_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS05045	COG0531	amino acid
CS376_RS05050	COG0733	neurotransmitter:sodium symporter activity
CS376_RS05065	COG1595	DNA-templated transcription, initiation
CS376_RS05070	COG0204	Acyl-transferase
CS376_RS05075	COG1253	flavin adenine dinucleotide binding
CS376_RS05080	COG0789	Transcriptional regulator
CS376_RS05085	COG0436	Aminotransferase
CS376_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS376_RS05095	COG1253	flavin adenine dinucleotide binding
CS376_RS05100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS376_RS05105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS376_RS05110	COG0584	glycerophosphoryl diester phosphodiesterase
CS376_RS05120	COG0668	transmembrane transport
CS376_RS05125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CS376_RS05130	COG0726	polysaccharide deacetylase
CS376_RS05135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS376_RS05140	COG3226	Transcriptional regulator
CS376_RS05150	COG0589	response to stress
CS376_RS05155	COG1132	(ABC) transporter
CS376_RS05160	COG1132	(ABC) transporter
CS376_RS05165	COG0702	epimerase
CS376_RS05190	COG0189	ligase activity
CS376_RS05195	COG0189	ligase activity
CS376_RS05210	COG4335	DNA alkylation repair
CS376_RS05220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS376_RS05230	COG0475	glutathione-regulated potassium exporter activity
CS376_RS05235	COG0490	domain, Protein
CS376_RS05245	COG1024	Enoyl-CoA hydratase
CS376_RS05255	COG4152	abc transporter atp-binding protein
CS376_RS05260	COG1668	transmembrane transport
CS376_RS05265	COG0420	3'-5' exonuclease activity
CS376_RS05270	COG4717	serine-type aminopeptidase activity
CS376_RS05285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS376_RS05330	COG4980	gas vesicle protein
CS376_RS05345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CS376_RS05350	COG0537	adenosine 5'-monophosphoramidase activity
CS376_RS05355	COG1131	(ABC) transporter
CS376_RS05360	COG4473	ABC transporter
CS376_RS05370	COG1473	amidohydrolase
CS376_RS05375	COG3069	C4-dicarboxylate transmembrane transporter activity
CS376_RS05380	COG2329	Antibiotic biosynthesis monooxygenase
CS376_RS05385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS376_RS05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CS376_RS05400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CS376_RS05405	COG1309	transcriptional regulator
CS376_RS05410	COG1511	domain protein
CS376_RS05415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS376_RS05425	COG1363	Peptidase, m42
CS376_RS05430	COG1301	dicarboxylic acid transport
CS376_RS05440	COG1234	tRNA 3'-trailer cleavage
CS376_RS05445	COG0095	Lipoate-protein ligase
CS376_RS05450	COG0702	epimerase
CS376_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS05465	COG0501	Belongs to the peptidase M48B family
CS376_RS05470	COG1404	Belongs to the peptidase S8 family
CS376_RS05480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CS376_RS05485	COG0406	alpha-ribazole phosphatase activity
CS376_RS05490	COG0183	Belongs to the thiolase family
CS376_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS05500	COG1268	BioY protein
CS376_RS05505	COG0840	transmembrane signaling receptor activity
CS376_RS05510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS376_RS05510	COG0723	plastoquinol--plastocyanin reductase activity
CS376_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS05525	COG4903	ComK protein
CS376_RS05535	COG5646	InterPro IPR014922
CS376_RS05560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS376_RS05575	COG0398	Pfam SNARE associated Golgi protein
CS376_RS05580	COG0681	Belongs to the peptidase S26 family
CS376_RS05585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CS376_RS05590	COG1846	Transcriptional regulator
CS376_RS05595	COG3180	Ammonia monooxygenase
CS376_RS05600	COG2814	Major facilitator Superfamily
CS376_RS05610	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CS376_RS05615	COG2323	membrane
CS376_RS05630	COG0420	3'-5' exonuclease activity
CS376_RS05635	COG0419	ATPase involved in DNA repair
CS376_RS05640	COG1403	HNH endonuclease
CS376_RS05680	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS376_RS05700	COG0367	asparagine synthase
CS376_RS05705	COG1562	ergosterol biosynthetic process
CS376_RS05710	COG0534	Mate efflux family protein
CS376_RS05715	COG2207	Transcriptional regulator
CS376_RS05715	COG1917	Cupin 2, conserved barrel domain protein
CS376_RS05720	COG2318	DinB family
CS376_RS05730	COG1357	PFAM Pentapeptide repeats (8 copies)
CS376_RS05735	COG2153	protein acetylation
CS376_RS05740	COG0646	methionine synthase
CS376_RS05740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CS376_RS05750	COG2996	Protein conserved in bacteria
CS376_RS05755	COG1744	ABC transporter substrate-binding protein PnrA-like
CS376_RS05760	COG0840	transmembrane signaling receptor activity
CS376_RS05765	COG2124	cytochrome p450
CS376_RS05775	COG1307	EDD domain protein, DegV family
CS376_RS05780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS05800	COG0561	phosphatase activity
CS376_RS05805	COG1073	alpha beta
CS376_RS05810	COG2151	metal-sulfur cluster biosynthetic enzyme
CS376_RS05820	COG0277	FAD linked oxidase domain protein
CS376_RS05825	COG2271	Major facilitator Superfamily
CS376_RS05835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CS376_RS05845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS376_RS05850	COG0505	Belongs to the CarA family
CS376_RS05855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CS376_RS05860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CS376_RS05880	COG2267	carboxylic ester hydrolase activity
CS376_RS05890	COG1744	ABC transporter substrate-binding protein PnrA-like
CS376_RS05905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS376_RS05910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS376_RS05915	COG5504	Zn-dependent protease
CS376_RS05920	COG0444	Belongs to the ABC transporter superfamily
CS376_RS05925	COG4608	Belongs to the ABC transporter superfamily
CS376_RS05935	COG0601	transmembrane transport
CS376_RS05940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS376_RS05950	COG0180	Tryptophanyl-tRNA synthetase
CS376_RS05955	COG4166	transmembrane transport
CS376_RS05960	COG0601	transmembrane transport
CS376_RS05965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS376_RS05970	COG0444	Belongs to the ABC transporter superfamily
CS376_RS05975	COG4608	Belongs to the ABC transporter superfamily
CS376_RS05985	COG0456	acetyltransferase
CS376_RS05990	COG1393	Belongs to the ArsC family
CS376_RS05995	COG0861	Integral membrane protein TerC family
CS376_RS06000	COG4862	establishment of competence for transformation
CS376_RS06005	COG4469	Competence protein
CS376_RS06010	COG1164	Oligoendopeptidase f
CS376_RS06020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS376_RS06025	COG2346	COG2346, Truncated hemoglobins
CS376_RS06030	COG0741	lytic transglycosylase activity
CS376_RS06035	COG4116	CYTH
CS376_RS06045	COG2357	RelA SpoT domain protein
CS376_RS06050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS376_RS06055	COG0564	pseudouridine synthase activity
CS376_RS06065	COG0475	glutathione-regulated potassium exporter activity
CS376_RS06065	COG0569	domain protein
CS376_RS06070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS376_RS06075	COG0352	thiamine-phosphate diphosphorylase activity
CS376_RS06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS376_RS06085	COG2104	thiamine diphosphate biosynthetic process
CS376_RS06095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS376_RS06100	COG0351	phosphomethylpyrimidine kinase
CS376_RS06105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CS376_RS06160	COG0210	DNA helicase
CS376_RS06180	COG1131	(ABC) transporter
CS376_RS06190	COG2153	protein acetylation
CS376_RS06200	COG2382	esterase
CS376_RS06205	COG0626	cystathionine gamma-synthase activity
CS376_RS06210	COG0626	cystathionine gamma-synthase activity
CS376_RS06285	COG3655	Transcriptional regulator
CS376_RS06350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CS376_RS06375	COG1780	Probably involved in ribonucleotide reductase function
CS376_RS06380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS376_RS06385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS376_RS06390	COG0756	dUTP diphosphatase activity
CS376_RS06400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CS376_RS06405	COG3584	3D domain protein
CS376_RS06405	COG1388	LysM domain
CS376_RS06445	COG1595	DNA-templated transcription, initiation
CS376_RS06460	COG1793	dna ligase
CS376_RS06485	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS06485	COG3420	alginic acid biosynthetic process
CS376_RS06490	COG4195	phage-related replication protein
CS376_RS06500	COG1216	Glycosyl transferase, family 2
CS376_RS06515	COG0582	viral genome integration into host DNA
CS376_RS06600	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS376_RS06610	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS06635	COG1388	LysM domain
CS376_RS06635	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS06635	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS06695	COG5444	nuclease activity
CS376_RS06750	COG0346	lactoylglutathione lyase activity
CS376_RS06755	COG2367	Beta-lactamase
CS376_RS06760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CS376_RS06765	COG0477	Major facilitator Superfamily
CS376_RS06770	COG1846	Transcriptional regulator
CS376_RS06780	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CS376_RS06785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS376_RS06790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS376_RS06795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS06795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS06800	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS376_RS06830	COG1285	pathogenesis
CS376_RS06845	COG2205	protein histidine kinase activity
CS376_RS06855	COG3383	formate dehydrogenase (NAD+) activity
CS376_RS06860	COG2427	Protein of unknown function (DUF1641)
CS376_RS06865	COG2124	cytochrome p450
CS376_RS06870	COG1819	glycosyl
CS376_RS06880	COG1587	Uroporphyrinogen-III synthase
CS376_RS06885	COG0390	transport system, permease component
CS376_RS06890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS376_RS06895	COG0697	spore germination
CS376_RS06900	COG4297	protein containing double-stranded beta helix domain
CS376_RS06910	COG1252	NADH dehydrogenase
CS376_RS06920	COG2211	Major facilitator Superfamily
CS376_RS06925	COG1609	Transcriptional regulator
CS376_RS06930	COG0246	Mannitol dehydrogenase
CS376_RS06935	COG2721	sulfolactate sulfo-lyase activity
CS376_RS06940	COG0730	response to heat
CS376_RS06945	COG2318	DinB family
CS376_RS06950	COG0457	Tetratricopeptide repeat
CS376_RS06960	COG1388	LysM domain
CS376_RS06960	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS06960	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS06970	COG4195	phage-related replication protein
CS376_RS06980	COG2856	Zn peptidase
CS376_RS06985	COG1396	sequence-specific DNA binding
CS376_RS06995	COG1522	sequence-specific DNA binding
CS376_RS07000	COG1484	DNA-dependent DNA replication
CS376_RS07020	COG1595	DNA-templated transcription, initiation
CS376_RS07025	COG5484	DNA packaging
CS376_RS07025	COG3728	DNA packaging
CS376_RS07030	COG1783	phage Terminase large subunit
CS376_RS07035	COG5518	Phage portal protein
CS376_RS07040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CS376_RS07045	COG4653	Phage capsid family
CS376_RS07095	COG5412	phage tail tape measure protein
CS376_RS07095	COG3953	SLT domain
CS376_RS07095	COG3953	SLT domain
CS376_RS07095	COG5412	phage tail tape measure protein
CS376_RS07095	COG3953	SLT domain
CS376_RS07095	COG5412	phage tail tape measure protein
CS376_RS07100	COG1652	LysM domain
CS376_RS07105	COG4193	domain, Protein
CS376_RS07115	COG3628	GPW Gp25 family protein
CS376_RS07120	COG3299	homolog of phage Mu protein gp47
CS376_RS07125	COG3778	Protein conserved in bacteria
CS376_RS07165	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS07165	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS07180	COG0306	phosphate transporter
CS376_RS07185	COG1392	Phosphate transport regulator
CS376_RS07190	COG0531	amino acid
CS376_RS07195	COG0346	lactoylglutathione lyase activity
CS376_RS07200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CS376_RS07205	COG0463	Glycosyl transferase, family 2
CS376_RS07210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS376_RS07215	COG0477	Major facilitator Superfamily
CS376_RS07220	COG2362	D-Aminopeptidase
CS376_RS07225	COG0601	transmembrane transport
CS376_RS07230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS376_RS07235	COG0444	Belongs to the ABC transporter superfamily
CS376_RS07240	COG4166	transmembrane transport
CS376_RS07245	COG1619	proteins homologs of microcin C7 resistance protein MccF
CS376_RS07250	COG4948	Mandelate Racemase Muconate Lactonizing
CS376_RS07255	COG0791	NLP P60 protein
CS376_RS07260	COG4608	Belongs to the ABC transporter superfamily
CS376_RS07265	COG2706	6-phosphogluconolactonase activity
CS376_RS07270	COG1834	amidinotransferase
CS376_RS07275	COG1607	acyl-coa hydrolase
CS376_RS07280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS376_RS07285	COG2076	Multidrug Resistance protein
CS376_RS07290	COG2076	Multidrug Resistance protein
CS376_RS07295	COG0788	formyltetrahydrofolate deformylase activity
CS376_RS07300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CS376_RS07310	COG1764	response to oxidative stress
CS376_RS07315	COG1846	Transcriptional regulator
CS376_RS07320	COG1764	response to oxidative stress
CS376_RS07335	COG0457	Tetratricopeptide repeat
CS376_RS07335	COG0463	Glycosyl transferase, family 2
CS376_RS07345	COG2814	Major facilitator Superfamily
CS376_RS07350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS376_RS07360	COG1404	Belongs to the peptidase S8 family
CS376_RS07365	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS07370	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CS376_RS07375	COG1122	ATPase activity
CS376_RS07380	COG4721	ABC-type cobalt transport system, permease component
CS376_RS07385	COG3858	chitin binding
CS376_RS07385	COG1388	LysM domain
CS376_RS07400	COG2239	Acts as a magnesium transporter
CS376_RS07405	COG0789	Transcriptional regulator
CS376_RS07420	COG1846	Transcriptional regulator
CS376_RS07425	COG0726	polysaccharide deacetylase
CS376_RS07430	COG1793	dna ligase
CS376_RS07430	COG3285	dna ligase
CS376_RS07435	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CS376_RS07445	COG0586	Pfam SNARE associated Golgi protein
CS376_RS07450	COG0861	Integral membrane protein TerC family
CS376_RS07455	COG1191	sigma factor activity
CS376_RS07485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS376_RS07490	COG2323	membrane
CS376_RS07500	COG3594	Acyltransferase
CS376_RS07505	COG5002	protein histidine kinase activity
CS376_RS07510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS376_RS07525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS376_RS07530	COG0436	Aminotransferase
CS376_RS07560	COG3852	Histidine kinase
CS376_RS07565	COG1846	Transcriptional regulator
CS376_RS07570	COG1360	Flagellar Motor Protein
CS376_RS07575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CS376_RS07580	COG0542	response to heat
CS376_RS07590	COG3949	Membrane
CS376_RS07605	COG0720	synthase
CS376_RS07610	COG0602	queuosine metabolic process
CS376_RS07620	COG1733	regulation of RNA biosynthetic process
CS376_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS07640	COG4873	Protein conserved in bacteria
CS376_RS07650	COG3773	Cell wall hydrolase
CS376_RS07655	COG2244	polysaccharide biosynthetic process
CS376_RS07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS07665	COG2217	Heavy metal translocating P-type atpase
CS376_RS07670	COG0006	proline dipeptidase activity
CS376_RS07675	COG1609	Transcriptional regulator
CS376_RS07680	COG3711	transcriptional antiterminator
CS376_RS07685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS07685	COG2190	(PTS) system
CS376_RS07685	COG1263	PTS System
CS376_RS07690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS07695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CS376_RS07705	COG1533	DNA photolyase activity
CS376_RS07710	COG0840	transmembrane signaling receptor activity
CS376_RS07715	COG2084	Dehydrogenase
CS376_RS07730	COG2340	Cysteine-rich secretory protein family
CS376_RS07735	COG0768	penicillin binding
CS376_RS07745	COG0436	Aminotransferase
CS376_RS07760	COG0784	Response regulator, receiver
CS376_RS07760	COG0835	chemotaxis
CS376_RS07770	COG2814	Major facilitator Superfamily
CS376_RS07775	COG1376	ErfK ybiS ycfS ynhG family protein
CS376_RS07780	COG1408	metallophosphoesterase
CS376_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS07795	COG2200	EAL domain
CS376_RS07800	COG4703	Protein of unknown function (DUF1797)
CS376_RS07805	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CS376_RS07815	COG0517	IMP dehydrogenase activity
CS376_RS07820	COG0583	DNA-binding transcription factor activity
CS376_RS07825	COG0716	FMN binding
CS376_RS07835	COG0716	FMN binding
CS376_RS07855	COG0668	transmembrane transport
CS376_RS07860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS07880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS376_RS07885	COG0303	'Molybdopterin
CS376_RS07890	COG1763	Mo-molybdopterin cofactor biosynthetic process
CS376_RS07895	COG0314	molybdopterin synthase activity
CS376_RS07900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CS376_RS07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS376_RS07915	COG1136	(ABC) transporter
CS376_RS07920	COG0577	efflux transmembrane transporter activity
CS376_RS07925	COG1349	DNA-binding transcription factor activity
CS376_RS07930	COG1105	Belongs to the carbohydrate kinase PfkB family
CS376_RS07935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS07935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS376_RS07935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS376_RS07940	COG0681	Belongs to the peptidase S26 family
CS376_RS07950	COG0488	(ABC) transporter
CS376_RS07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS376_RS07960	COG2309	aminopeptidase activity
CS376_RS07970	COG1077	Cell shape determining protein MreB Mrl
CS376_RS07980	COG2002	toxin-antitoxin pair type II binding
CS376_RS07985	COG3852	Histidine kinase
CS376_RS07990	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CS376_RS07990	COG2105	PFAM AIG2 family protein
CS376_RS07995	COG0569	domain protein
CS376_RS08005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS376_RS08015	COG0561	phosphatase activity
CS376_RS08020	COG0242	peptide deformylase activity
CS376_RS08030	COG0497	DNA recombination
CS376_RS08045	COG4221	oxidoreductase activity
CS376_RS08045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS08045	COG3321	synthase
CS376_RS08050	COG0300	oxidoreductase activity
CS376_RS08050	COG4221	oxidoreductase activity
CS376_RS08050	COG3321	synthase
CS376_RS08050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS08055	COG4221	oxidoreductase activity
CS376_RS08055	COG3321	synthase
CS376_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS08055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS08060	COG4221	oxidoreductase activity
CS376_RS08060	COG0300	oxidoreductase activity
CS376_RS08060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS08060	COG3321	synthase
CS376_RS08065	COG4221	oxidoreductase activity
CS376_RS08065	COG3321	synthase
CS376_RS08065	COG0300	oxidoreductase activity
CS376_RS08065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS08070	COG0300	oxidoreductase activity
CS376_RS08070	COG3321	synthase
CS376_RS08070	COG4221	oxidoreductase activity
CS376_RS08070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS08075	COG4221	oxidoreductase activity
CS376_RS08075	COG3321	synthase
CS376_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS08075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS08080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS376_RS08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS376_RS08090	COG0022	dehydrogenase e1 component
CS376_RS08095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS376_RS08100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS376_RS08105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS08120	COG1982	Orn Lys Arg decarboxylase major
CS376_RS08145	COG0483	inositol monophosphate 1-phosphatase activity
CS376_RS08155	COG3227	Zinc metalloprotease (Elastase)
CS376_RS08170	COG1595	DNA-templated transcription, initiation
CS376_RS08190	COG1217	gtp-binding protein TYPA
CS376_RS08200	COG4896	Protein conserved in bacteria
CS376_RS08210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CS376_RS08215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS376_RS08220	COG2066	Belongs to the glutaminase family
CS376_RS08230	COG0772	Belongs to the SEDS family
CS376_RS08235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS376_RS08250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CS376_RS08250	COG2010	Cytochrome c
CS376_RS08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS376_RS08260	COG1845	cytochrome c oxidase, subunit III
CS376_RS08265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CS376_RS08270	COG3336	cytochrome c oxidase
CS376_RS08280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CS376_RS08285	COG2340	Cysteine-rich secretory protein family
CS376_RS08300	COG3679	Belongs to the UPF0342 family
CS376_RS08315	COG0742	ribosomal rna small subunit methyltransferase
CS376_RS08325	COG3314	Sporulation integral membrane protein YlbJ
CS376_RS08330	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS376_RS08335	COG3480	Lon protease (S16) C-terminal proteolytic domain
CS376_RS08345	COG1399	metal-binding, possibly nucleic acid-binding protein
CS376_RS08365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS376_RS08385	COG4839	cell division protein FtsL
CS376_RS08390	COG0768	penicillin binding
CS376_RS08395	COG0768	penicillin binding
CS376_RS08415	COG0772	Belongs to the SEDS family
CS376_RS08430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CS376_RS08435	COG0849	cell division
CS376_RS08440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS376_RS08445	COG1404	Belongs to the peptidase S8 family
CS376_RS08445	COG4412	M6 family metalloprotease domain protein
CS376_RS08455	COG1191	sigma factor activity
CS376_RS08460	COG1191	sigma factor activity
CS376_RS08465	COG1119	ATPase activity
CS376_RS08470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS376_RS08475	COG1873	PFAM PRC-barrel domain
CS376_RS08480	COG1496	oxidoreductase activity
CS376_RS08485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CS376_RS08495	COG0762	integral membrane protein
CS376_RS08500	COG2302	S4 RNA-binding domain
CS376_RS08505	COG3599	regulation of cell shape
CS376_RS08515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CS376_RS08520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS376_RS08530	COG0564	pseudouridine synthase activity
CS376_RS08540	COG2233	PERMEase
CS376_RS08550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS376_RS08555	COG0505	Belongs to the CarA family
CS376_RS08560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CS376_RS08575	COG0284	orotidine-5'-phosphate decarboxylase activity
CS376_RS08580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CS376_RS08590	COG0306	phosphate transporter
CS376_RS08605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CS376_RS08610	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CS376_RS08615	COG1648	precorrin-2 dehydrogenase activity
CS376_RS08630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CS376_RS08635	COG1561	YicC-like family, N-terminal region
CS376_RS08645	COG0194	GDP metabolic process
CS376_RS08655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS376_RS08660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS376_RS08665	COG0242	peptide deformylase activity
CS376_RS08675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CS376_RS08675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS376_RS08685	COG0631	protein serine/threonine phosphatase activity
CS376_RS08690	COG2815	serine threonine protein kinase
CS376_RS08690	COG0515	serine threonine protein kinase
CS376_RS08700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS376_RS08705	COG1564	THIamine pyrophosphokinase
CS376_RS08720	COG1302	Protein conserved in bacteria
CS376_RS08725	COG1461	Dihydroxyacetone kinase
CS376_RS08730	COG1760	l-serine dehydratase
CS376_RS08735	COG1760	l-serine dehydratase
CS376_RS08740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS376_RS08755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS376_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS08780	COG0552	protein localization to endoplasmic reticulum
CS376_RS08795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS376_RS08805	COG1837	Belongs to the UPF0109 family
CS376_RS08830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CS376_RS08845	COG2257	FlhB HrpN YscU SpaS Family
CS376_RS08855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CS376_RS08860	COG0758	DNA mediated transformation
CS376_RS08865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS376_RS08875	COG4974	Belongs to the 'phage' integrase family
CS376_RS08895	COG1815	bacterial-type flagellum-dependent cell motility
CS376_RS08900	COG1558	bacterial-type flagellum-dependent cell motility
CS376_RS08905	COG1677	Flagellar hook-basal body complex protein FliE
CS376_RS08910	COG1766	The M ring may be actively involved in energy transduction
CS376_RS08915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS376_RS08920	COG1317	bacterial-type flagellum organization
CS376_RS08925	COG1157	protein secretion by the type III secretion system
CS376_RS08930	COG2882	bacterial-type flagellum organization
CS376_RS08935	COG3334	PFAM MgtE intracellular
CS376_RS08940	COG3144	bacterial-type flagellum assembly
CS376_RS08945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CS376_RS08950	COG4786	Flagellar basal body rod
CS376_RS08955	COG1582	Flagellar protein (FlbD)
CS376_RS08960	COG1580	Controls the rotational direction of flagella during chemotaxis
CS376_RS08965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS376_RS08970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS376_RS08970	COG1776	CheC inhibitor of MCP methylation
CS376_RS08975	COG2201	protein-glutamate methylesterase activity
CS376_RS08980	COG3190	flagellar
CS376_RS08985	COG1338	Plays a role in the flagellum-specific transport system
CS376_RS08990	COG1987	bacterial-type flagellum assembly
CS376_RS08995	COG1684	flagellar biosynthetic protein fliR
CS376_RS09000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS376_RS09005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS376_RS09010	COG1419	protein localization to endoplasmic reticulum
CS376_RS09015	COG0455	bacterial-type flagellum organization
CS376_RS09020	COG2201	protein-glutamate methylesterase activity
CS376_RS09025	COG0643	Histidine kinase
CS376_RS09025	COG2198	Histidine kinase
CS376_RS09030	COG0835	chemotaxis
CS376_RS09035	COG1776	CheC inhibitor of MCP methylation
CS376_RS09045	COG1191	sigma factor activity
CS376_RS09075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CS376_RS09080	COG4589	Belongs to the CDS family
CS376_RS09090	COG0750	zinc metalloprotease
CS376_RS09100	COG2176	DNA-directed DNA polymerase activity
CS376_RS09110	COG0195	Participates in both transcription termination and antitermination
CS376_RS09115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CS376_RS09120	COG1358	cellular component organization or biogenesis
CS376_RS09130	COG1550	Protein conserved in bacteria
CS376_RS09145	COG0196	riboflavin kinase activity
CS376_RS09160	COG0726	polysaccharide deacetylase
CS376_RS09165	COG0612	Peptidase, M16
CS376_RS09170	COG1873	PFAM PRC-barrel domain
CS376_RS09175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS376_RS09180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS376_RS09185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CS376_RS09190	COG0527	aspartate kinase activity
CS376_RS09200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS376_RS09205	COG0740	serine-type endopeptidase activity
CS376_RS09220	COG2188	Transcriptional regulator
CS376_RS09225	COG2814	Major facilitator Superfamily
CS376_RS09230	COG1846	Transcriptional regulator
CS376_RS09235	COG1033	growth of symbiont in host cell
CS376_RS09235	COG2409	Drug exporters of the RND superfamily
CS376_RS09240	COG0612	Peptidase, M16
CS376_RS09245	COG0612	Peptidase, M16
CS376_RS09250	COG0300	oxidoreductase activity
CS376_RS09265	COG1426	Protein conserved in bacteria
CS376_RS09270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CS376_RS09285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CS376_RS09295	COG1692	metallophosphoesterase
CS376_RS09300	COG2359	stage V sporulation protein S
CS376_RS09320	COG4550	Control of competence regulator ComK, YlbF/YmcA
CS376_RS09365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS09370	COG3425	synthase
CS376_RS09375	COG1024	Enoyl-CoA hydratase
CS376_RS09380	COG1024	Enoyl-CoA hydratase
CS376_RS09385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS09385	COG0300	oxidoreductase activity
CS376_RS09385	COG3321	synthase
CS376_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS09390	COG3321	synthase
CS376_RS09390	COG4221	oxidoreductase activity
CS376_RS09390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS09390	COG0300	oxidoreductase activity
CS376_RS09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS09395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS09395	COG3321	synthase
CS376_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS09395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS09395	COG3321	synthase
CS376_RS09400	COG3321	synthase
CS376_RS09400	COG4221	oxidoreductase activity
CS376_RS09400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS09405	COG3321	synthase
CS376_RS09405	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CS376_RS09405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CS376_RS09405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS09410	COG2124	cytochrome p450
CS376_RS09415	COG3209	COG3209 Rhs family protein
CS376_RS09420	COG3619	membrane
CS376_RS09430	COG1404	Belongs to the peptidase S8 family
CS376_RS09440	COG4195	phage-related replication protein
CS376_RS09445	COG1764	response to oxidative stress
CS376_RS09455	COG2076	Multidrug Resistance protein
CS376_RS09495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS376_RS09500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS376_RS09505	COG4112	unkown
CS376_RS09520	COG0464	growth
CS376_RS09525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS376_RS09530	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CS376_RS09535	COG0789	Transcriptional regulator
CS376_RS09540	COG0174	glutamine synthetase
CS376_RS09570	COG0457	Tetratricopeptide repeat
CS376_RS09580	COG2211	Major facilitator Superfamily
CS376_RS09585	COG3507	Belongs to the glycosyl hydrolase 43 family
CS376_RS09600	COG1070	Carbohydrate kinase
CS376_RS09605	COG0574	Belongs to the PEP-utilizing enzyme family
CS376_RS09605	COG3848	Pyruvate phosphate dikinase
CS376_RS09635	COG1064	alcohol dehydrogenase
CS376_RS09665	COG0456	acetyltransferase
CS376_RS09700	COG3397	chitin binding
CS376_RS09725	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS09730	COG0756	dUTP diphosphatase activity
CS376_RS09740	COG4195	phage-related replication protein
CS376_RS09770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CS376_RS09780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS376_RS09800	COG0785	Cytochrome C biogenesis protein
CS376_RS09805	COG2201	protein-glutamate methylesterase activity
CS376_RS09810	COG4846	Membrane protein involved in cytochrome C biogenesis
CS376_RS09820	COG0071	Belongs to the small heat shock protein (HSP20) family
CS376_RS09835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CS376_RS09840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS09860	COG0824	Thioesterase
CS376_RS09870	COG4841	protein insertion into membrane
CS376_RS09880	COG1832	CoA-binding protein
CS376_RS09885	COG0187	DNA topoisomerase II activity
CS376_RS09890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS376_RS09900	COG1115	amino acid carrier protein
CS376_RS09910	COG1063	alcohol dehydrogenase
CS376_RS09915	COG0800	Aldolase
CS376_RS09920	COG1312	Catalyzes the dehydration of D-mannonate
CS376_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS09930	COG1609	Transcriptional regulator
CS376_RS09935	COG2271	Major facilitator Superfamily
CS376_RS09990	COG0745	RESPONSE REGULATOR receiver
CS376_RS10000	COG3507	Belongs to the glycosyl hydrolase 43 family
CS376_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS10030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS376_RS10035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS376_RS10040	COG2610	gluconate transmembrane transporter activity
CS376_RS10045	COG2124	cytochrome p450
CS376_RS10065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS376_RS10075	COG2246	polysaccharide biosynthetic process
CS376_RS10080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS376_RS10085	COG0586	Pfam SNARE associated Golgi protein
CS376_RS10090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS376_RS10095	COG1024	Enoyl-CoA hydratase
CS376_RS10100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS376_RS10105	COG0511	ligase activity, forming carbon-carbon bonds
CS376_RS10110	COG0439	Biotin carboxylase
CS376_RS10115	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS10120	COG1960	acyl-CoA dehydrogenase activity
CS376_RS10125	COG1649	PFAM Uncharacterised BCR, COG1649
CS376_RS10135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CS376_RS10135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS10140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS10145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS10155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS10165	COG2027	D-alanyl-D-alanine carboxypeptidase
CS376_RS10170	COG2017	converts alpha-aldose to the beta-anomer
CS376_RS10175	COG0534	Mate efflux family protein
CS376_RS10185	COG5444	nuclease activity
CS376_RS10200	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS10200	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS10205	COG4824	toxin secretion phage lysis holin
CS376_RS10225	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS10230	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS376_RS10230	COG1388	LysM domain
CS376_RS10305	COG1802	Transcriptional regulator
CS376_RS10305	COG4626	Terminase
CS376_RS10340	COG0582	viral genome integration into host DNA
CS376_RS10345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS376_RS10440	COG4974	Belongs to the 'phage' integrase family
CS376_RS10450	COG0582	viral genome integration into host DNA
CS376_RS10455	COG0166	Belongs to the GPI family
CS376_RS10460	COG0405	Gamma-glutamyltransferase
CS376_RS10465	COG2814	Major facilitator Superfamily
CS376_RS10470	COG0640	Transcriptional regulator
CS376_RS10475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS376_RS10485	COG0604	alcohol dehydrogenase
CS376_RS10490	COG0493	'glutamate synthase
CS376_RS10500	COG0583	DNA-binding transcription factor activity
CS376_RS10505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CS376_RS10525	COG0300	oxidoreductase activity
CS376_RS10530	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CS376_RS10540	COG2814	Major facilitator Superfamily
CS376_RS10545	COG1070	Carbohydrate kinase
CS376_RS10550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS376_RS10555	COG0243	molybdopterin cofactor binding
CS376_RS10585	COG5444	nuclease activity
CS376_RS10590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS376_RS10595	COG0662	Cupin 2, conserved barrel domain protein
CS376_RS10595	COG2207	Transcriptional regulator
CS376_RS10600	COG1309	transcriptional regulator
CS376_RS10605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS10615	COG0640	Transcriptional regulator
CS376_RS10620	COG0741	lytic transglycosylase activity
CS376_RS10625	COG2322	membrane
CS376_RS10640	COG1619	proteins homologs of microcin C7 resistance protein MccF
CS376_RS10650	COG3584	3D domain protein
CS376_RS10650	COG1388	LysM domain
CS376_RS10655	COG0514	ATP-dependent DNA helicase (RecQ)
CS376_RS10665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS376_RS10670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS376_RS10685	COG0071	Belongs to the small heat shock protein (HSP20) family
CS376_RS10715	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS10720	COG1657	PFAM Prenyltransferase squalene oxidase
CS376_RS10725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS376_RS10730	COG0733	neurotransmitter:sodium symporter activity
CS376_RS10735	COG0385	Bile acid
CS376_RS10740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS10745	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS376_RS10755	COG4548	von Willebrand factor, type A
CS376_RS10760	COG0714	Associated with various cellular activities
CS376_RS10765	COG2032	superoxide dismutase activity
CS376_RS10770	COG1388	LysM domain
CS376_RS10770	COG0791	NLP P60 protein
CS376_RS10775	COG1819	glycosyl
CS376_RS10780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS376_RS10785	COG0534	Mate efflux family protein
CS376_RS10790	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS10795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS376_RS10800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS376_RS10810	COG2962	Rard protein
CS376_RS10825	COG1942	4-Oxalocrotonate Tautomerase
CS376_RS10835	COG1733	regulation of RNA biosynthetic process
CS376_RS10840	COG0778	Nitroreductase
CS376_RS10845	COG0400	carboxylic ester hydrolase activity
CS376_RS10850	COG0346	lactoylglutathione lyase activity
CS376_RS10860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS376_RS10870	COG2723	6-phospho-beta-galactosidase activity
CS376_RS10875	COG2188	Transcriptional regulator
CS376_RS10880	COG0793	Belongs to the peptidase S41A family
CS376_RS10880	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS10885	COG2226	methyltransferase
CS376_RS10895	COG1876	peptidase activity
CS376_RS10915	COG0671	phosphoesterase, PA-phosphatase related
CS376_RS10945	COG1509	lysine 2,3-aminomutase activity
CS376_RS10950	COG0456	acetyltransferase
CS376_RS10955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS376_RS10960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS376_RS10965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS376_RS10970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS376_RS10975	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CS376_RS10985	COG0456	acetyltransferase
CS376_RS10990	COG0463	Glycosyl transferase, family 2
CS376_RS11005	COG4641	Protein conserved in bacteria
CS376_RS11015	COG1086	Polysaccharide biosynthesis protein
CS376_RS11045	COG0457	Tetratricopeptide repeat
CS376_RS11055	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS11070	COG5444	nuclease activity
CS376_RS11115	COG3655	Transcriptional regulator
CS376_RS11145	COG0457	Tetratricopeptide repeat
CS376_RS11185	COG5444	nuclease activity
CS376_RS11190	COG4282	regulation of fungal-type cell wall biogenesis
CS376_RS11205	COG1525	nuclease
CS376_RS11225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CS376_RS11245	COG1846	Transcriptional regulator
CS376_RS11250	COG4698	Protein conserved in bacteria
CS376_RS11255	COG2755	lipolytic protein G-D-S-L family
CS376_RS11260	COG1999	signal sequence binding
CS376_RS11270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CS376_RS11275	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CS376_RS11280	COG1272	protein, Hemolysin III
CS376_RS11285	COG0204	Acyl-transferase
CS376_RS11290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS376_RS11305	COG2136	Putative SAM-dependent methyltransferase
CS376_RS11305	COG2521	methyltransferase
CS376_RS11320	COG1413	lyase activity
CS376_RS11325	COG1418	mRNA catabolic process
CS376_RS11330	COG0386	Belongs to the glutathione peroxidase family
CS376_RS11340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS376_RS11345	COG1278	Cold shock
CS376_RS11365	COG0328	RNA-DNA hybrid ribonuclease activity
CS376_RS11370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CS376_RS11375	COG0328	RNA-DNA hybrid ribonuclease activity
CS376_RS11385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS376_RS11400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS376_RS11410	COG1755	Isoprenylcysteine carboxyl methyltransferase
CS376_RS11415	COG3424	synthase
CS376_RS11435	COG2323	membrane
CS376_RS11440	COG1335	isochorismatase
CS376_RS11450	COG2233	PERMEase
CS376_RS11460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CS376_RS11465	COG1199	ATP-dependent helicase activity
CS376_RS11480	COG0116	Belongs to the methyltransferase superfamily
CS376_RS11505	COG3359	exonuclease
CS376_RS11510	COG1205	dead DEAH box helicase
CS376_RS11510	COG1111	helicase
CS376_RS11515	COG2190	(PTS) system
CS376_RS11520	COG0071	Belongs to the small heat shock protein (HSP20) family
CS376_RS11560	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS376_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS376_RS11570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS376_RS11575	COG3935	DnaD domain protein
CS376_RS11585	COG0436	Aminotransferase
CS376_RS11590	COG5353	protein conserved in bacteria
CS376_RS11600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CS376_RS11600	COG1199	ATP-dependent helicase activity
CS376_RS11630	COG0438	transferase activity, transferring glycosyl groups
CS376_RS11635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS376_RS11650	COG1694	Mazg nucleotide pyrophosphohydrolase
CS376_RS11655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS11660	COG2140	Oxalate decarboxylase
CS376_RS11670	COG4347	Protein of unknown function (DUF1405)
CS376_RS11675	COG2010	Cytochrome c
CS376_RS11675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CS376_RS11680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CS376_RS11685	COG0723	plastoquinol--plastocyanin reductase activity
CS376_RS11700	COG0457	Tetratricopeptide repeat
CS376_RS11710	COG0287	Prephenate dehydrogenase
CS376_RS11745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS376_RS11750	COG4401	Chorismate mutase type I
CS376_RS11765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CS376_RS11770	COG0105	UTP biosynthetic process
CS376_RS11775	COG0142	geranyltranstransferase activity
CS376_RS11785	COG0142	geranyltranstransferase activity
CS376_RS11800	COG0776	regulation of translation
CS376_RS11805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS376_RS11845	COG0539	negative regulation of cytoplasmic translation
CS376_RS11860	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CS376_RS11865	COG2959	enzyme of heme biosynthesis
CS376_RS11870	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS11870	COG3773	Cell wall hydrolase
CS376_RS11875	COG2339	peptidase activity
CS376_RS11880	COG0492	ferredoxin-NADP+ reductase activity
CS376_RS11885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS376_RS11890	COG4862	establishment of competence for transformation
CS376_RS11895	COG1408	metallophosphoesterase
CS376_RS11905	COG1388	LysM domain
CS376_RS11910	COG1266	CAAX protease self-immunity
CS376_RS11915	COG0514	ATP-dependent DNA helicase (RecQ)
CS376_RS11920	COG4955	Helix-turn-helix domain
CS376_RS11925	COG1141	Ferredoxin
CS376_RS11930	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CS376_RS11935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS376_RS11945	COG1595	DNA-templated transcription, initiation
CS376_RS11950	COG5002	protein histidine kinase activity
CS376_RS11955	COG0745	RESPONSE REGULATOR receiver
CS376_RS11960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS376_RS11965	COG1333	cytochrome c biogenesis protein
CS376_RS11970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS11975	COG1187	pseudouridine synthase activity
CS376_RS11980	COG0700	Nucleoside recognition
CS376_RS11985	COG2715	membrane protein required for spore maturation
CS376_RS11990	COG1686	Belongs to the peptidase S11 family
CS376_RS12015	COG1547	Domain of unknown function (DUF309)
CS376_RS12025	COG0456	acetyltransferase
CS376_RS12040	COG0307	riboflavin synthase, alpha
CS376_RS12045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS376_RS12045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS376_RS12055	COG0681	Belongs to the peptidase S26 family
CS376_RS12065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CS376_RS12070	COG4086	secreted protein
CS376_RS12075	COG0019	diaminopimelate decarboxylase activity
CS376_RS12080	COG0697	spore germination
CS376_RS12095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS376_RS12115	COG1191	sigma factor activity
CS376_RS12125	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS12130	COG1686	Belongs to the peptidase S11 family
CS376_RS12135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CS376_RS12140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CS376_RS12145	COG4974	Belongs to the 'phage' integrase family
CS376_RS12155	COG0735	belongs to the Fur family
CS376_RS12160	COG1300	Membrane
CS376_RS12175	COG0281	malic enzyme
CS376_RS12180	COG1757	Na H antiporter
CS376_RS12185	COG1027	Aspartate ammonia-lyase
CS376_RS12190	COG0252	asparaginase activity
CS376_RS12195	COG1396	sequence-specific DNA binding
CS376_RS12200	COG1379	DNA repair
CS376_RS12205	COG0494	nUDIX hydrolase
CS376_RS12215	COG0667	Aldo Keto reductase
CS376_RS12225	COG1073	alpha beta
CS376_RS12235	COG4918	Iron-sulphur cluster biosynthesis
CS376_RS12240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS376_RS12240	COG0456	acetyltransferase
CS376_RS12245	COG2329	Antibiotic biosynthesis monooxygenase
CS376_RS12250	COG0456	acetyltransferase
CS376_RS12255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS376_RS12270	COG0628	permease
CS376_RS12280	COG0346	lactoylglutathione lyase activity
CS376_RS12290	COG3048	D-serine ammonia-lyase activity
CS376_RS12295	COG0300	oxidoreductase activity
CS376_RS12300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS12305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS376_RS12310	COG1024	Enoyl-CoA hydratase
CS376_RS12315	COG3425	synthase
CS376_RS12320	COG2124	cytochrome p450
CS376_RS12325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS12325	COG3321	synthase
CS376_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS12330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS12330	COG3321	synthase
CS376_RS12330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12335	COG0300	oxidoreductase activity
CS376_RS12335	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12335	COG3321	synthase
CS376_RS12335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12340	COG0300	oxidoreductase activity
CS376_RS12340	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS12340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12340	COG3321	synthase
CS376_RS12345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS376_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12345	COG3321	synthase
CS376_RS12345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS12350	COG3321	synthase
CS376_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS12350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS12350	COG0300	oxidoreductase activity
CS376_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS12380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS376_RS12380	COG2070	2-Nitropropane dioxygenase
CS376_RS12390	COG0250	Participates in transcription elongation, termination and antitermination
CS376_RS12415	COG0596	Alpha beta hydrolase
CS376_RS12430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS376_RS12435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CS376_RS12450	COG0706	membrane insertase activity
CS376_RS12455	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS376_RS12460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS376_RS12465	COG0346	lactoylglutathione lyase activity
CS376_RS12470	COG1376	ErfK ybiS ycfS ynhG family protein
CS376_RS12475	COG4129	membrane
CS376_RS12480	COG1126	abc transporter atp-binding protein
CS376_RS12485	COG0765	amino acid transport
CS376_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS12500	COG1597	lipid kinase activity
CS376_RS12505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS376_RS12510	COG0022	dehydrogenase e1 component
CS376_RS12515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS376_RS12520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS376_RS12525	COG3426	butyrate kinase activity
CS376_RS12530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS376_RS12535	COG0280	phosphate acetyltransferase
CS376_RS12540	COG3829	transcription factor binding
CS376_RS12540	COG3290	protein histidine kinase activity
CS376_RS12550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CS376_RS12555	COG2079	MmgE PrpD family protein
CS376_RS12560	COG0372	Belongs to the citrate synthase family
CS376_RS12565	COG1960	acyl-CoA dehydrogenase activity
CS376_RS12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS376_RS12575	COG0183	Belongs to the thiolase family
CS376_RS12580	COG0584	glycerophosphoryl diester phosphodiesterase
CS376_RS12585	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS376_RS12610	COG1902	pentaerythritol trinitrate reductase activity
CS376_RS12625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS376_RS12630	COG0745	RESPONSE REGULATOR receiver
CS376_RS12635	COG0750	zinc metalloprotease
CS376_RS12640	COG0497	DNA recombination
CS376_RS12650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CS376_RS12660	COG0142	geranyltranstransferase activity
CS376_RS12670	COG1570	exodeoxyribonuclease VII activity
CS376_RS12685	COG1302	Protein conserved in bacteria
CS376_RS12690	COG0439	Biotin carboxylase
CS376_RS12695	COG0511	ligase activity, forming carbon-carbon bonds
CS376_RS12735	COG3854	ATPases associated with a variety of cellular activities
CS376_RS12750	COG0006	proline dipeptidase activity
CS376_RS12760	COG3872	metal-dependent enzyme
CS376_RS12770	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS376_RS12785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS376_RS12805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS376_RS12820	COG1396	sequence-specific DNA binding
CS376_RS12830	COG0681	Belongs to the peptidase S26 family
CS376_RS12855	COG4940	Competence protein ComGF
CS376_RS12865	COG4970	Tfp pilus assembly protein FimT
CS376_RS12870	COG4537	Required for transformation and DNA binding
CS376_RS12875	COG1459	type II secretion system
CS376_RS12880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CS376_RS12885	COG0598	Magnesium transport protein CorA
CS376_RS12890	COG1253	flavin adenine dinucleotide binding
CS376_RS12895	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS12905	COG1393	Belongs to the ArsC family
CS376_RS12915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS12925	COG0011	TIGRFAM Protein of
CS376_RS12935	COG2866	Carboxypeptidase
CS376_RS12940	COG1940	carbohydrate kinase activity
CS376_RS12945	COG4483	Protein conserved in bacteria
CS376_RS12950	COG1757	Na H antiporter
CS376_RS12960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS376_RS12975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS376_RS12980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS376_RS12985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS376_RS12990	COG0581	inorganic phosphate transmembrane transporter activity
CS376_RS12995	COG0573	inorganic phosphate transmembrane transporter activity
CS376_RS13000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CS376_RS13005	COG0768	penicillin binding
CS376_RS13010	COG0477	Major facilitator Superfamily
CS376_RS13015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS376_RS13020	COG2839	Protein conserved in bacteria
CS376_RS13025	COG5521	maltodextrose utilization protein MalA
CS376_RS13030	COG1388	LysM domain
CS376_RS13040	COG4709	membrane
CS376_RS13045	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CS376_RS13050	COG0735	belongs to the Fur family
CS376_RS13055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS13070	COG0513	Belongs to the DEAD box helicase family
CS376_RS13085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS376_RS13090	COG2384	SAM-dependent methyltransferase
CS376_RS13095	COG2010	Cytochrome c
CS376_RS13100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CS376_RS13105	COG0358	DNA primase activity
CS376_RS13120	COG0517	IMP dehydrogenase activity
CS376_RS13125	COG0751	glycine-tRNA ligase activity
CS376_RS13145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS376_RS13150	COG0295	cytidine deaminase activity
CS376_RS13155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CS376_RS13165	COG1480	7TM receptor with intracellular HD hydrolase
CS376_RS13170	COG1702	phosphate starvation-inducible protein PhoH
CS376_RS13175	COG0561	phosphatase activity
CS376_RS13190	COG4864	UPF0365 protein
CS376_RS13195	COG1030	water channel activity
CS376_RS13200	COG1610	YqeY-like protein
CS376_RS13210	COG1283	sodium-dependent phosphate transmembrane transporter activity
CS376_RS13215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS376_RS13220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS376_RS13250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS376_RS13280	COG1466	dna polymerase III delta subunit
CS376_RS13290	COG0658	competence protein
CS376_RS13290	COG2333	competence protein COMEC
CS376_RS13295	COG2131	deaminase
CS376_RS13300	COG1596	polysaccharide export
CS376_RS13300	COG1555	photosystem II stabilization
CS376_RS13305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS376_RS13310	COG2226	methyltransferase
CS376_RS13315	COG0799	negative regulation of ribosome biogenesis
CS376_RS13320	COG1713	HD superfamily hydrolase involved in NAD metabolism
CS376_RS13330	COG1534	Rna-binding protein
CS376_RS13335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS376_RS13340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CS376_RS13345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CS376_RS13355	COG2755	lipolytic protein G-D-S-L family
CS376_RS13365	COG0398	Pfam SNARE associated Golgi protein
CS376_RS13385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CS376_RS13415	COG0457	Tetratricopeptide repeat
CS376_RS13420	COG5444	nuclease activity
CS376_RS13425	COG1525	nuclease
CS376_RS13430	COG5444	nuclease activity
CS376_RS13435	COG4282	regulation of fungal-type cell wall biogenesis
CS376_RS13455	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS13455	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS13460	COG4824	toxin secretion phage lysis holin
CS376_RS13490	COG3778	Protein conserved in bacteria
CS376_RS13495	COG3299	homolog of phage Mu protein gp47
CS376_RS13500	COG3628	GPW Gp25 family protein
CS376_RS13510	COG4193	domain, Protein
CS376_RS13515	COG1652	LysM domain
CS376_RS13520	COG5280	Phage tail tape measure protein TP901
CS376_RS13520	COG3953	SLT domain
CS376_RS13580	COG4653	Phage capsid family
CS376_RS13585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CS376_RS13595	COG2369	cell adhesion
CS376_RS13600	COG5518	Phage portal protein
CS376_RS13610	COG5484	DNA packaging
CS376_RS13620	COG3677	Transposase
CS376_RS13640	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CS376_RS13650	COG1484	DNA-dependent DNA replication
CS376_RS13655	COG3935	DnaD domain protein
CS376_RS13660	COG3723	Recombinational DNA repair protein, rece pathway
CS376_RS13665	COG5377	YqaJ viral recombinase family
CS376_RS13695	COG3620	sequence-specific DNA binding
CS376_RS13705	COG2856	Zn peptidase
CS376_RS13730	COG0642	Histidine kinase
CS376_RS13730	COG5002	protein histidine kinase activity
CS376_RS13735	COG0745	RESPONSE REGULATOR receiver
CS376_RS13740	COG2311	Membrane
CS376_RS13745	COG0454	-acetyltransferase
CS376_RS13750	COG0563	adenylate kinase activity
CS376_RS13765	COG0456	acetyltransferase
CS376_RS13770	COG2318	DinB family
CS376_RS13780	COG0561	phosphatase activity
CS376_RS13785	COG0561	phosphatase activity
CS376_RS13795	COG1482	cell wall glycoprotein biosynthetic process
CS376_RS13800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS376_RS13800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS376_RS13800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS13805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS13805	COG3711	transcriptional antiterminator
CS376_RS13815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS376_RS13820	COG0583	DNA-binding transcription factor activity
CS376_RS13825	COG2814	Major facilitator Superfamily
CS376_RS13830	COG2124	cytochrome p450
CS376_RS13830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS376_RS13835	COG1309	transcriptional regulator
CS376_RS13840	COG2226	methyltransferase
CS376_RS13855	COG2116	formate transmembrane transporter activity
CS376_RS13860	COG5609	conserved protein (DUF2294)
CS376_RS13865	COG3383	formate dehydrogenase (NAD+) activity
CS376_RS13870	COG2427	Protein of unknown function (DUF1641)
CS376_RS13880	COG0626	cystathionine gamma-synthase activity
CS376_RS13885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS376_RS13910	COG0768	penicillin binding
CS376_RS13945	COG5632	N-Acetylmuramoyl-L-alanine amidase
CS376_RS13945	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS13950	COG4824	toxin secretion phage lysis holin
CS376_RS13970	COG5434	Belongs to the glycosyl hydrolase 28 family
CS376_RS13975	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS376_RS13985	COG5280	Phage tail tape measure protein TP901
CS376_RS13985	COG3953	SLT domain
CS376_RS14080	COG0582	viral genome integration into host DNA
CS376_RS14085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS376_RS14205	COG1396	sequence-specific DNA binding
CS376_RS14225	COG0826	peptidase U32
CS376_RS14230	COG0826	peptidase U32
CS376_RS14235	COG4122	O-methyltransferase activity
CS376_RS14240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS376_RS14265	COG0628	permease
CS376_RS14270	COG1126	abc transporter atp-binding protein
CS376_RS14275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS14280	COG0765	amino acid transport
CS376_RS14285	COG0765	amino acid transport
CS376_RS14300	COG3881	PFAM PRC-barrel domain
CS376_RS14305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS376_RS14310	COG0457	Tetratricopeptide repeat
CS376_RS14320	COG1104	cysteine desulfurase activity
CS376_RS14325	COG1959	2 iron, 2 sulfur cluster binding
CS376_RS14330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS376_RS14335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CS376_RS14360	COG4991	sh3 domain protein
CS376_RS14360	COG3103	Sh3 type 3 domain protein
CS376_RS14360	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS376_RS14370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS376_RS14380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CS376_RS14380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS376_RS14385	COG5416	Lipopolysaccharide assembly protein A domain
CS376_RS14390	COG0490	domain, Protein
CS376_RS14395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS376_RS14395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS376_RS14405	COG2244	polysaccharide biosynthetic process
CS376_RS14410	COG2323	membrane
CS376_RS14420	COG1862	Preprotein translocase
CS376_RS14465	COG1388	LysM domain
CS376_RS14475	COG0157	Belongs to the NadC ModD family
CS376_RS14480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CS376_RS14485	COG1104	cysteine desulfurase activity
CS376_RS14490	COG1827	regulation of RNA biosynthetic process
CS376_RS14495	COG0077	Prephenate dehydratase
CS376_RS14510	COG3290	protein histidine kinase activity
CS376_RS14515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CS376_RS14520	COG2868	ribosomal protein
CS376_RS14530	COG1994	Peptidase M50
CS376_RS14535	COG0739	heme binding
CS376_RS14540	COG2894	cell division
CS376_RS14550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CS376_RS14560	COG1077	Cell shape determining protein MreB Mrl
CS376_RS14585	COG0285	dihydrofolate synthase activity
CS376_RS14590	COG0525	valine-tRNA ligase activity
CS376_RS14600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS376_RS14605	COG1388	LysM domain
CS376_RS14615	COG0113	porphobilinogen synthase activity
CS376_RS14620	COG1587	Uroporphyrinogen-III synthase
CS376_RS14630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS376_RS14650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CS376_RS14655	COG1067	ATP-dependent peptidase activity
CS376_RS14655	COG0470	DNA polymerase III
CS376_RS14670	COG0457	Tetratricopeptide repeat
CS376_RS14670	COG1477	protein flavinylation
CS376_RS14685	COG0473	3-isopropylmalate dehydrogenase activity
CS376_RS14700	COG0440	acetolactate synthase activity
CS376_RS14705	COG0028	Belongs to the TPP enzyme family
CS376_RS14735	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CS376_RS14755	COG0622	Phosphoesterase
CS376_RS14760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CS376_RS14770	COG5401	PFAM Sporulation and spore germination
CS376_RS14780	COG1846	Transcriptional regulator
CS376_RS14785	COG2197	response regulator
CS376_RS14790	COG0824	Thioesterase
CS376_RS14795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CS376_RS14800	COG1053	succinate dehydrogenase
CS376_RS14805	COG2009	succinate dehydrogenase
CS376_RS14810	COG1719	4-vinyl reductase, 4VR
CS376_RS14815	COG0527	aspartate kinase activity
CS376_RS14830	COG3118	belongs to the thioredoxin family
CS376_RS14835	COG3534	alpha-L-arabinofuranosidase
CS376_RS14840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS376_RS14845	COG2086	electron transfer activity
CS376_RS14850	COG1024	Enoyl-CoA hydratase
CS376_RS14855	COG1309	transcriptional regulator
CS376_RS14860	COG0318	PFAM AMP-dependent synthetase and ligase
CS376_RS14870	COG3766	membrane
CS376_RS14880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS376_RS14880	COG1796	DNA polymerase
CS376_RS14885	COG1286	toxin biosynthetic process
CS376_RS14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS376_RS14900	COG0072	phenylalanine-tRNA ligase activity
CS376_RS14905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CS376_RS14910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS376_RS14920	COG3835	regulator
CS376_RS14925	COG0277	FAD linked oxidase domain protein
CS376_RS14930	COG0247	lactate metabolic process
CS376_RS14935	COG1966	Carbon starvation protein
CS376_RS14940	COG3534	alpha-L-arabinofuranosidase
CS376_RS14945	COG0395	ABC-type sugar transport system, permease component
CS376_RS14950	COG1175	transmembrane transport
CS376_RS14955	COG1653	transport
CS376_RS14965	COG0647	UMP catabolic process
CS376_RS14970	COG0235	Class ii aldolase
CS376_RS14975	COG1069	ribulokinase activity
CS376_RS14980	COG2160	L-arabinose isomerase activity
CS376_RS14985	COG3507	Belongs to the glycosyl hydrolase 43 family
CS376_RS14990	COG1363	Peptidase, m42
CS376_RS15000	COG3326	Membrane
CS376_RS15015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CS376_RS15020	COG1346	cytolysis
CS376_RS15025	COG1380	Effector of murein hydrolase LrgA
CS376_RS15030	COG3279	Response regulator of the LytR AlgR family
CS376_RS15035	COG3275	phosphorelay sensor kinase activity
CS376_RS15040	COG1011	Hydrolase
CS376_RS15055	COG0398	Pfam SNARE associated Golgi protein
CS376_RS15060	COG1484	DNA-dependent DNA replication
CS376_RS15065	COG3611	Membrane attachment protein
CS376_RS15080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CS376_RS15085	COG1733	regulation of RNA biosynthetic process
CS376_RS15090	COG2814	Major facilitator Superfamily
CS376_RS15095	COG0656	L-ascorbic acid biosynthetic process
CS376_RS15100	COG0237	dephospho-CoA kinase activity
CS376_RS15105	COG1971	Probably functions as a manganese efflux pump
CS376_RS15110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CS376_RS15115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS376_RS15115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS376_RS15120	COG5002	protein histidine kinase activity
CS376_RS15125	COG0745	RESPONSE REGULATOR receiver
CS376_RS15135	COG0538	isocitrate dehydrogenase activity
CS376_RS15140	COG0372	Belongs to the citrate synthase family
CS376_RS15165	COG0628	permease
CS376_RS15170	COG3030	protein affecting phage T7 exclusion by the F plasmid
CS376_RS15175	COG0469	pyruvate kinase activity
CS376_RS15195	COG0281	malic enzyme
CS376_RS15200	COG0587	DNA-directed DNA polymerase activity
CS376_RS15220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CS376_RS15230	COG4109	DRTGG domain
CS376_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS15260	COG0521	Mo-molybdopterin cofactor biosynthetic process
CS376_RS15270	COG0827	DNA restriction-modification system
CS376_RS15275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CS376_RS15280	COG3874	Sporulation protein YtfJ
CS376_RS15290	COG1714	RDD family
CS376_RS15295	COG0616	signal peptide processing
CS376_RS15300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS376_RS15305	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CS376_RS15310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS376_RS15325	COG1104	cysteine desulfurase activity
CS376_RS15330	COG1114	Component of the transport system for branched-chain amino acids
CS376_RS15340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS376_RS15345	COG1309	transcriptional regulator
CS376_RS15350	COG1956	GAF domain-containing protein
CS376_RS15355	COG2199	diguanylate cyclase activity
CS376_RS15355	COG2203	Gaf domain
CS376_RS15370	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS15375	COG4282	regulation of fungal-type cell wall biogenesis
CS376_RS15410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS376_RS15410	COG1017	nitric oxide dioxygenase activity
CS376_RS15420	COG0693	protein deglycase activity
CS376_RS15435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS376_RS15440	COG1378	Sugar-specific transcriptional regulator TrmB
CS376_RS15465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS376_RS15470	COG0454	-acetyltransferase
CS376_RS15475	COG0517	IMP dehydrogenase activity
CS376_RS15480	COG0123	including yeast histone deacetylase and acetoin utilization protein
CS376_RS15485	COG1360	Flagellar Motor Protein
CS376_RS15490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CS376_RS15495	COG1609	Transcriptional regulator
CS376_RS15500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CS376_RS15500	COG1605	Chorismate mutase
CS376_RS15505	COG3118	belongs to the thioredoxin family
CS376_RS15510	COG4980	gas vesicle protein
CS376_RS15515	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CS376_RS15525	COG1674	ftsk spoiiie
CS376_RS15530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS376_RS15540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS15550	COG1363	Peptidase, m42
CS376_RS15555	COG5584	Small secreted protein
CS376_RS15560	COG0281	malic enzyme
CS376_RS15565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS376_RS15580	COG0510	thiamine kinase activity
CS376_RS15585	COG1597	lipid kinase activity
CS376_RS15595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CS376_RS15600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS376_RS15605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS376_RS15610	COG2252	PERMEase
CS376_RS15615	COG4473	ABC transporter
CS376_RS15620	COG1131	(ABC) transporter
CS376_RS15625	COG1349	DNA-binding transcription factor activity
CS376_RS15630	COG1187	pseudouridine synthase activity
CS376_RS15635	COG2244	polysaccharide biosynthetic process
CS376_RS15640	COG2081	HI0933 family
CS376_RS15645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CS376_RS15655	COG1609	Transcriptional regulator
CS376_RS15660	COG1653	transport
CS376_RS15665	COG1175	transmembrane transport
CS376_RS15670	COG0395	ABC-type sugar transport system, permease component
CS376_RS15675	COG1486	melibiose metabolic process
CS376_RS15685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS376_RS15700	COG1366	Belongs to the anti-sigma-factor antagonist family
CS376_RS15700	COG2202	Pas domain
CS376_RS15705	COG2814	Major facilitator Superfamily
CS376_RS15710	COG5522	Integral membrane protein (intg_mem_TP0381)
CS376_RS15715	COG0577	efflux transmembrane transporter activity
CS376_RS15720	COG1136	(ABC) transporter
CS376_RS15725	COG2205	protein histidine kinase activity
CS376_RS15730	COG0745	RESPONSE REGULATOR receiver
CS376_RS15735	COG0577	efflux transmembrane transporter activity
CS376_RS15740	COG1136	(ABC) transporter
CS376_RS15760	COG1131	(ABC) transporter
CS376_RS15765	COG1725	Transcriptional regulator
CS376_RS15775	COG1242	4 iron, 4 sulfur cluster binding
CS376_RS15780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CS376_RS15790	COG0584	glycerophosphoryl diester phosphodiesterase
CS376_RS15800	COG2267	carboxylic ester hydrolase activity
CS376_RS15805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS376_RS15810	COG1113	amino acid transport
CS376_RS15815	COG0367	asparagine synthase
CS376_RS15835	COG1506	peptidase
CS376_RS15840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS376_RS15845	COG1116	anion transmembrane transporter activity
CS376_RS15850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS376_RS15855	COG0494	nUDIX hydrolase
CS376_RS15860	COG4824	toxin secretion phage lysis holin
CS376_RS15865	COG0783	Belongs to the Dps family
CS376_RS15890	COG0288	reversible hydration of carbon dioxide
CS376_RS15900	COG1271	oxidase subunit
CS376_RS15905	COG1294	oxidase, subunit
CS376_RS15920	COG4948	Mandelate Racemase Muconate Lactonizing
CS376_RS15930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CS376_RS15935	COG0596	Alpha beta hydrolase
CS376_RS15945	COG1169	isochorismate synthase
CS376_RS15950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS376_RS15955	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CS376_RS16080	COG3859	Proton-coupled thiamine transporter YuaJ
CS376_RS16085	COG2268	Band 7 protein
CS376_RS16090	COG1585	Membrane protein implicated in regulation of membrane protease activity
CS376_RS16095	COG2318	DinB family
CS376_RS16105	COG1454	alcohol dehydrogenase
CS376_RS16110	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS16115	COG1510	regulation of RNA biosynthetic process
CS376_RS16125	COG0569	domain protein
CS376_RS16130	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS376_RS16135	COG1017	nitric oxide dioxygenase activity
CS376_RS16135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS376_RS16160	COG0628	permease
CS376_RS16165	COG0673	inositol 2-dehydrogenase activity
CS376_RS16170	COG0693	protein deglycase activity
CS376_RS16175	COG0840	transmembrane signaling receptor activity
CS376_RS16180	COG0840	transmembrane signaling receptor activity
CS376_RS16185	COG0840	transmembrane signaling receptor activity
CS376_RS16190	COG0840	transmembrane signaling receptor activity
CS376_RS16205	COG2070	2-Nitropropane dioxygenase
CS376_RS16210	COG0432	Pfam Uncharacterised protein family UPF0047
CS376_RS16215	COG0366	Alpha amylase catalytic
CS376_RS16220	COG1253	flavin adenine dinucleotide binding
CS376_RS16225	COG2738	Putative neutral zinc metallopeptidase
CS376_RS16240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS376_RS16270	COG1335	isochorismatase
CS376_RS16275	COG1979	alcohol dehydrogenase
CS376_RS16280	COG1979	alcohol dehydrogenase
CS376_RS16285	COG2155	Conserved Protein
CS376_RS16290	COG1098	S1 RNA binding domain
CS376_RS16295	COG0436	Aminotransferase
CS376_RS16300	COG1522	sequence-specific DNA binding
CS376_RS16305	COG2267	carboxylic ester hydrolase activity
CS376_RS16320	COG2205	protein histidine kinase activity
CS376_RS16330	COG5018	Exonuclease
CS376_RS16335	COG2814	Major facilitator Superfamily
CS376_RS16340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS376_RS16345	COG3011	Protein conserved in bacteria
CS376_RS16355	COG3290	protein histidine kinase activity
CS376_RS16360	COG4565	transcriptional regulatory protein
CS376_RS16365	COG1744	ABC transporter substrate-binding protein PnrA-like
CS376_RS16370	COG3845	ABC transporter
CS376_RS16375	COG4603	Belongs to the binding-protein-dependent transport system permease family
CS376_RS16380	COG1079	Belongs to the binding-protein-dependent transport system permease family
CS376_RS16390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CS376_RS16390	COG2111	Na H antiporter
CS376_RS16395	COG2111	Na H antiporter
CS376_RS16400	COG1006	Multisubunit Na H antiporter MnhC subunit
CS376_RS16405	COG0651	ATP synthesis coupled electron transport
CS376_RS16410	COG1863	multisubunit Na H antiporter MnhE subunit
CS376_RS16415	COG2212	antiporter activity
CS376_RS16420	COG1320	monovalent cation:proton antiporter activity
CS376_RS16425	COG2050	protein possibly involved in aromatic compounds catabolism
CS376_RS16430	COG2197	response regulator
CS376_RS16435	COG4585	Histidine kinase
CS376_RS16445	COG0142	geranyltranstransferase activity
CS376_RS16465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CS376_RS16470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS376_RS16475	COG1335	isochorismatase
CS376_RS16480	COG5506	Protein of unknown function (DUF1694)
CS376_RS16495	COG0628	permease
CS376_RS16505	COG1418	mRNA catabolic process
CS376_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS16520	COG1511	domain protein
CS376_RS16525	COG1674	ftsk spoiiie
CS376_RS16525	COG0433	COG0433 Predicted ATPase
CS376_RS16530	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS376_RS16535	COG5417	Belongs to the EsaB family
CS376_RS16540	COG4842	Belongs to the WXG100 family
CS376_RS16545	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CS376_RS16545	COG2508	Transcriptional regulator
CS376_RS16550	COG0686	Belongs to the AlaDH PNT family
CS376_RS16555	COG5634	Uncharacterized conserved protein (DUF2278)
CS376_RS16560	COG3251	PFAM MbtH domain protein
CS376_RS16565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CS376_RS16570	COG1535	isochorismatase
CS376_RS16570	COG3433	isochorismatase activity
CS376_RS16575	COG1021	2,3-dihydroxybenzoate-AMP ligase
CS376_RS16580	COG1169	isochorismate synthase
CS376_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS16590	COG2819	hydrolase of the alpha beta superfamily
CS376_RS16595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS376_RS16600	COG1268	BioY protein
CS376_RS16605	COG2056	Na+-H+ antiporter family
CS376_RS16615	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CS376_RS16620	COG3584	3D domain protein
CS376_RS16630	COG1252	NADH dehydrogenase
CS376_RS16660	COG1131	(ABC) transporter
CS376_RS16685	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CS376_RS16690	COG0316	Belongs to the HesB IscA family
CS376_RS16700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS376_RS16710	COG1252	NADH dehydrogenase
CS376_RS16715	COG4837	Protein of unknown function (DUF1462)
CS376_RS16720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CS376_RS16725	COG4946	Tricorn protease homolog
CS376_RS16725	COG1506	peptidase
CS376_RS16725	COG0823	Involved in the tonB-independent uptake of proteins
CS376_RS16735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS376_RS16740	COG0460	homoserine dehydrogenase
CS376_RS16745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS376_RS16750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS376_RS16755	COG0647	UMP catabolic process
CS376_RS16760	COG2445	Protein of unknown function DUF86
CS376_RS16765	COG4470	Protein conserved in bacteria
CS376_RS16780	COG0739	heme binding
CS376_RS16790	COG0737	Belongs to the 5'-nucleotidase family
CS376_RS16795	COG0730	response to heat
CS376_RS16800	COG1801	Protein of unknown function DUF72
CS376_RS16815	COG2508	Transcriptional regulator
CS376_RS16820	COG0457	Tetratricopeptide repeat
CS376_RS16835	COG2814	Major facilitator Superfamily
CS376_RS16840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CS376_RS16845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS376_RS16850	COG2356	endonuclease I
CS376_RS16855	COG3842	ATPase activity
CS376_RS16860	COG2188	Transcriptional regulator
CS376_RS16865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS376_RS16870	COG0395	ABC-type sugar transport system, permease component
CS376_RS16875	COG1175	transmembrane transport
CS376_RS16880	COG1653	transport
CS376_RS16885	COG2222	sugar isomerase
CS376_RS16890	COG0789	Transcriptional regulator
CS376_RS16915	COG0322	excinuclease ABC activity
CS376_RS16920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS376_RS16925	COG2226	methyltransferase
CS376_RS16935	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS16940	COG0719	Fe-S assembly protein
CS376_RS16945	COG0822	iron-sulfur transferase activity
CS376_RS16950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS376_RS16955	COG0719	Fe-S assembly protein
CS376_RS16960	COG0396	ATPase activity
CS376_RS16970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CS376_RS16975	COG1464	Belongs to the NlpA lipoprotein family
CS376_RS16980	COG2011	ABC-type metal ion transport system permease component
CS376_RS16985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS376_RS16995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS376_RS17000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CS376_RS17015	COG1393	Belongs to the ArsC family
CS376_RS17020	COG1960	acyl-CoA dehydrogenase activity
CS376_RS17025	COG0183	Belongs to the thiolase family
CS376_RS17030	COG1024	Enoyl-CoA hydratase
CS376_RS17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS376_RS17050	COG5577	PFAM Coat F domain
CS376_RS17055	COG1846	Transcriptional regulator
CS376_RS17060	COG0477	Major facilitator Superfamily
CS376_RS17065	COG1942	4-Oxalocrotonate Tautomerase
CS376_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS17075	COG0583	DNA-binding transcription factor activity
CS376_RS17085	COG0583	DNA-binding transcription factor activity
CS376_RS17105	COG1120	ATPase activity
CS376_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS17125	COG0783	Belongs to the Dps family
CS376_RS17130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS376_RS17135	COG0745	RESPONSE REGULATOR receiver
CS376_RS17140	COG2770	Histidine kinase
CS376_RS17140	COG2205	protein histidine kinase activity
CS376_RS17150	COG1309	transcriptional regulator
CS376_RS17155	COG0114	fumarate hydratase activity
CS376_RS17165	COG0697	spore germination
CS376_RS17170	COG0814	amino acid
CS376_RS17180	COG2197	response regulator
CS376_RS17185	COG4585	Histidine kinase
CS376_RS17190	COG4758	membrane
CS376_RS17195	COG3595	metallopeptidase activity
CS376_RS17200	COG1842	Phage shock protein A
CS376_RS17205	COG4758	membrane
CS376_RS17210	COG2814	Major facilitator Superfamily
CS376_RS17215	COG2096	Adenosyltransferase
CS376_RS17220	COG1120	ATPase activity
CS376_RS17225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS376_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS17240	COG3386	PFAM SMP-30 Gluconolaconase
CS376_RS17245	COG2205	protein histidine kinase activity
CS376_RS17250	COG0745	RESPONSE REGULATOR receiver
CS376_RS17260	COG1191	sigma factor activity
CS376_RS17270	COG2140	Oxalate decarboxylase
CS376_RS17280	COG1120	ATPase activity
CS376_RS17285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS17290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS17295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS376_RS17305	COG0531	amino acid
CS376_RS17320	COG1988	membrane-bound metal-dependent
CS376_RS17325	COG1368	sulfuric ester hydrolase activity
CS376_RS17330	COG1910	domain protein
CS376_RS17335	COG0725	ABC transporter, periplasmic molybdate-binding protein
CS376_RS17340	COG4149	molybdate abc transporter
CS376_RS17345	COG2197	response regulator
CS376_RS17350	COG3850	Histidine kinase
CS376_RS17355	COG1131	(ABC) transporter
CS376_RS17365	COG0842	Transport permease protein
CS376_RS17370	COG0656	L-ascorbic acid biosynthetic process
CS376_RS17395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS376_RS17400	COG3973	AAA domain
CS376_RS17405	COG2860	membrane
CS376_RS17415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CS376_RS17420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CS376_RS17425	COG2217	Heavy metal translocating P-type atpase
CS376_RS17430	COG2217	Heavy metal translocating P-type atpase
CS376_RS17435	COG2608	mercury ion transmembrane transporter activity
CS376_RS17440	COG1937	Protein conserved in bacteria
CS376_RS17445	COG0673	inositol 2-dehydrogenase activity
CS376_RS17465	COG2814	Major facilitator Superfamily
CS376_RS17480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS17485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CS376_RS17490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS17495	COG1126	abc transporter atp-binding protein
CS376_RS17500	COG0765	amino acid transport
CS376_RS17505	COG0765	amino acid transport
CS376_RS17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS17515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS376_RS17520	COG0454	-acetyltransferase
CS376_RS17525	COG0583	DNA-binding transcription factor activity
CS376_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS17535	COG2732	(Barnase) inhibitor
CS376_RS17550	COG0557	exoribonuclease II activity
CS376_RS17555	COG1647	Serine aminopeptidase, S33
CS376_RS17560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS376_RS17565	COG1476	TRANSCRIPTIONal
CS376_RS17570	COG1396	sequence-specific DNA binding
CS376_RS17575	COG1396	sequence-specific DNA binding
CS376_RS17580	COG1733	regulation of RNA biosynthetic process
CS376_RS17605	COG1131	(ABC) transporter
CS376_RS17610	COG1174	glycine betaine transport
CS376_RS17615	COG1732	Glycine betaine
CS376_RS17620	COG1174	glycine betaine transport
CS376_RS17625	COG0517	IMP dehydrogenase activity
CS376_RS17625	COG1125	glycine betaine transport
CS376_RS17630	COG1510	regulation of RNA biosynthetic process
CS376_RS17635	COG1174	glycine betaine transport
CS376_RS17640	COG1732	Glycine betaine
CS376_RS17645	COG1174	glycine betaine transport
CS376_RS17650	COG0517	IMP dehydrogenase activity
CS376_RS17650	COG1125	glycine betaine transport
CS376_RS17655	COG1510	regulation of RNA biosynthetic process
CS376_RS17660	COG2095	MarC family integral membrane protein
CS376_RS17665	COG3064	Membrane
CS376_RS17670	COG4640	response to antibiotic
CS376_RS17675	COG0456	acetyltransferase
CS376_RS17690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS376_RS17705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS376_RS17710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS376_RS17715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS376_RS17725	COG2234	aminopeptidase activity
CS376_RS17745	COG0126	phosphoglycerate kinase activity
CS376_RS17755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CS376_RS17760	COG2390	Transcriptional regulator
CS376_RS17765	COG2814	Major facilitator Superfamily
CS376_RS17770	COG1609	Transcriptional regulator
CS376_RS17775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS17785	COG0583	DNA-binding transcription factor activity
CS376_RS17790	COG0697	spore germination
CS376_RS17795	COG1113	amino acid transport
CS376_RS17805	COG1609	Transcriptional regulator
CS376_RS17815	COG0561	phosphatase activity
CS376_RS17820	COG1737	Transcriptional regulator
CS376_RS17825	COG1070	Carbohydrate kinase
CS376_RS17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS17855	COG2186	Transcriptional regulator
CS376_RS17860	COG1620	l-lactate permease
CS376_RS17865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS376_RS17875	COG5039	Polysaccharide pyruvyl transferase
CS376_RS17880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS376_RS17885	COG0110	maltose O-acetyltransferase activity
CS376_RS17890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS376_RS17895	COG2244	polysaccharide biosynthetic process
CS376_RS17900	COG1216	Glycosyl transferase, family 2
CS376_RS17905	COG5039	Polysaccharide pyruvyl transferase
CS376_RS17910	COG1216	Glycosyl transferase, family 2
CS376_RS17920	COG0438	transferase activity, transferring glycosyl groups
CS376_RS17925	COG1215	transferase activity, transferring glycosyl groups
CS376_RS17930	COG0438	transferase activity, transferring glycosyl groups
CS376_RS17940	COG0489	protein tyrosine kinase activity
CS376_RS17945	COG3944	biosynthesis protein
CS376_RS17950	COG1396	sequence-specific DNA binding
CS376_RS18025	COG1357	PFAM Pentapeptide repeats (8 copies)
CS376_RS18050	COG2223	nitrite transmembrane transporter activity
CS376_RS18055	COG1609	Transcriptional regulator
CS376_RS18065	COG0583	DNA-binding transcription factor activity
CS376_RS18070	COG2828	Protein conserved in bacteria
CS376_RS18075	COG2814	Major facilitator Superfamily
CS376_RS18075	COG0477	Major facilitator Superfamily
CS376_RS18080	COG1611	Belongs to the LOG family
CS376_RS18085	COG1694	Mazg nucleotide pyrophosphohydrolase
CS376_RS18090	COG0659	secondary active sulfate transmembrane transporter activity
CS376_RS18095	COG0288	reversible hydration of carbon dioxide
CS376_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS376_RS18110	COG4290	ribonuclease
CS376_RS18115	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CS376_RS18120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS18130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CS376_RS18140	COG1051	belongs to the nudix hydrolase family
CS376_RS18145	COG0492	ferredoxin-NADP+ reductase activity
CS376_RS18150	COG3883	PFAM NLP P60 protein
CS376_RS18150	COG0791	NLP P60 protein
CS376_RS18155	COG0457	Tetratricopeptide repeat
CS376_RS18160	COG5002	protein histidine kinase activity
CS376_RS18165	COG0745	RESPONSE REGULATOR receiver
CS376_RS18170	COG1132	(ABC) transporter
CS376_RS18175	COG0140	phosphoribosyl-ATP diphosphatase activity
CS376_RS18175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CS376_RS18200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CS376_RS18215	COG4990	cell redox homeostasis
CS376_RS18220	COG0110	maltose O-acetyltransferase activity
CS376_RS18240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CS376_RS18250	COG2188	Transcriptional regulator
CS376_RS18255	COG1309	transcriptional regulator
CS376_RS18260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CS376_RS18265	COG1950	PFAM Membrane protein of
CS376_RS18270	COG1983	PspC domain protein
CS376_RS18275	COG3595	metallopeptidase activity
CS376_RS18290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CS376_RS18300	COG4897	Protein conserved in bacteria
CS376_RS18305	COG3848	Pyruvate phosphate dikinase
CS376_RS18305	COG0574	Belongs to the PEP-utilizing enzyme family
CS376_RS18310	COG1309	transcriptional regulator
CS376_RS18315	COG2814	Major facilitator Superfamily
CS376_RS18330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS376_RS18340	COG3409	Peptidoglycan-binding domain 1 protein
CS376_RS18340	COG0793	Belongs to the peptidase S41A family
CS376_RS18345	COG3420	alginic acid biosynthetic process
CS376_RS18350	COG2177	Part of the ABC transporter FtsEX involved in
CS376_RS18355	COG2884	Cell division ATP-binding protein ftsE
CS376_RS18360	COG2010	Cytochrome c
CS376_RS18365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS18380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CS376_RS18395	COG1516	flagellar protein fliS
CS376_RS18400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CS376_RS18405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS376_RS18425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS376_RS18430	COG4786	Flagellar basal body rod
CS376_RS18430	COG1256	bacterial-type flagellum assembly
CS376_RS18435	COG3418	PFAM FlgN family protein
CS376_RS18440	COG2747	anti-sigma28 factor FlgM
CS376_RS18450	COG1040	competence protein
CS376_RS18460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CS376_RS18465	COG1307	EDD domain protein, DegV family
CS376_RS18470	COG2197	response regulator
CS376_RS18475	COG4585	Histidine kinase
CS376_RS18480	COG1739	Uncharacterized protein family UPF0029
CS376_RS18485	COG1316	TRANSCRIPTIONal
CS376_RS18490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS376_RS18495	COG0438	transferase activity, transferring glycosyl groups
CS376_RS18500	COG1215	transferase activity, transferring glycosyl groups
CS376_RS18505	COG3206	protein involved in exopolysaccharide biosynthesis
CS376_RS18510	COG3307	-O-antigen
CS376_RS18515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CS376_RS18520	COG0297	glycogen (starch) synthase activity
CS376_RS18520	COG0438	transferase activity, transferring glycosyl groups
CS376_RS18525	COG2244	polysaccharide biosynthetic process
CS376_RS18535	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS376_RS18535	COG2247	cell wall binding repeat
CS376_RS18540	COG2247	cell wall binding repeat
CS376_RS18540	COG2385	sporulation resulting in formation of a cellular spore
CS376_RS18550	COG1316	TRANSCRIPTIONal
CS376_RS18555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CS376_RS18560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS376_RS18565	COG1134	teichoic acid transport
CS376_RS18570	COG1682	transport, permease protein
CS376_RS18575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CS376_RS18585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CS376_RS18590	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CS376_RS18595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CS376_RS18600	COG4193	domain, Protein
CS376_RS18605	COG1482	cell wall glycoprotein biosynthetic process
CS376_RS18610	COG0697	spore germination
CS376_RS18615	COG0814	amino acid
CS376_RS18625	COG1215	transferase activity, transferring glycosyl groups
CS376_RS18630	COG2814	Major facilitator Superfamily
CS376_RS18635	COG1316	TRANSCRIPTIONal
CS376_RS18640	COG0561	phosphatase activity
CS376_RS18645	COG2433	Pfam Transposase IS66
CS376_RS18650	COG0791	NLP P60 protein
CS376_RS18660	COG2843	Capsule synthesis protein
CS376_RS18670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CS376_RS18680	COG0697	spore germination
CS376_RS18685	COG0814	amino acid
CS376_RS18695	COG1609	Transcriptional regulator
CS376_RS18700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS376_RS18710	COG1129	ABC transporter
CS376_RS18715	COG1172	Belongs to the binding-protein-dependent transport system permease family
CS376_RS18720	COG1879	ABC-type sugar transport system periplasmic component
CS376_RS18725	COG3103	Sh3 type 3 domain protein
CS376_RS18730	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS376_RS18735	COG3527	Alpha-acetolactate decarboxylase
CS376_RS18740	COG0028	Belongs to the TPP enzyme family
CS376_RS18745	COG0583	DNA-binding transcription factor activity
CS376_RS18750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS376_RS18765	COG5337	Spore coat protein CotH
CS376_RS18775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS376_RS18785	COG0405	Gamma-glutamyltransferase
CS376_RS18790	COG1522	sequence-specific DNA binding
CS376_RS18795	COG2059	Chromate
CS376_RS18800	COG2059	Chromate
CS376_RS18825	COG5444	nuclease activity
CS376_RS18840	COG3878	Protein conserved in bacteria
CS376_RS18845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CS376_RS18850	COG4464	protein tyrosine phosphatase activity
CS376_RS18855	COG0489	protein tyrosine kinase activity
CS376_RS18860	COG3944	biosynthesis protein
CS376_RS18875	COG4715	Zinc finger, swim domain protein
CS376_RS18880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS376_RS18885	COG0561	phosphatase activity
CS376_RS18890	COG1349	DNA-binding transcription factor activity
CS376_RS18895	COG0629	single-stranded DNA binding
CS376_RS18920	COG0457	Tetratricopeptide repeat
CS376_RS18925	COG4786	Flagellar basal body rod
CS376_RS18930	COG4786	Flagellar basal body rod
CS376_RS18935	COG1077	Cell shape determining protein MreB Mrl
CS376_RS18940	COG1609	Transcriptional regulator
CS376_RS18945	COG1846	Transcriptional regulator
CS376_RS18950	COG2814	Major facilitator Superfamily
CS376_RS18955	COG1953	Uracil, thiamine, allantoin
CS376_RS18960	COG0477	Major facilitator Superfamily
CS376_RS18965	COG1335	isochorismatase
CS376_RS18970	COG0004	ammonium transporteR
CS376_RS18975	COG0347	Belongs to the P(II) protein family
CS376_RS18980	COG0772	Belongs to the SEDS family
CS376_RS18985	COG0671	phosphoesterase, PA-phosphatase related
CS376_RS18995	COG0739	heme binding
CS376_RS19000	COG1247	-acetyltransferase
CS376_RS19015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS376_RS19030	COG0726	polysaccharide deacetylase
CS376_RS19040	COG1959	2 iron, 2 sulfur cluster binding
CS376_RS19055	COG0831	urea catabolic process
CS376_RS19060	COG3237	CsbD-like
CS376_RS19065	COG1994	Peptidase M50
CS376_RS19070	COG0457	Tetratricopeptide repeat
CS376_RS19080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CS376_RS19090	COG2304	oxidoreductase activity
CS376_RS19095	COG2304	oxidoreductase activity
CS376_RS19105	COG2385	sporulation resulting in formation of a cellular spore
CS376_RS19110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CS376_RS19120	COG4836	Membrane
CS376_RS19190	COG0698	ribose 5-phosphate isomerase
CS376_RS19195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS376_RS19205	COG0009	L-threonylcarbamoyladenylate synthase
CS376_RS19210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CS376_RS19230	COG2890	protein-(glutamine-N5) methyltransferase activity
CS376_RS19235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CS376_RS19240	COG0346	lactoylglutathione lyase activity
CS376_RS19245	COG0789	Transcriptional regulator
CS376_RS19250	COG0679	Auxin Efflux Carrier
CS376_RS19255	COG0281	malic enzyme
CS376_RS19270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CS376_RS19275	COG1494	fructose-1,6-bisphosphatase
CS376_RS19280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CS376_RS19290	COG0191	fructose-bisphosphate aldolase activity
CS376_RS19295	COG2204	response regulator
CS376_RS19300	COG4821	SIS domain
CS376_RS19315	COG2181	nitrate reductase activity
CS376_RS19315	COG0247	lactate metabolic process
CS376_RS19320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS376_RS19335	COG1132	(ABC) transporter
CS376_RS19340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS376_RS19350	COG2181	nitrate reductase activity
CS376_RS19355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CS376_RS19360	COG1140	nitrate reductase beta subunit
CS376_RS19365	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CS376_RS19370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS376_RS19380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS376_RS19385	COG2223	nitrite transmembrane transporter activity
CS376_RS19395	COG4506	Protein conserved in bacteria
CS376_RS19405	COG3391	amine dehydrogenase activity
CS376_RS19410	COG3391	amine dehydrogenase activity
CS376_RS19420	COG0457	Tetratricopeptide repeat
CS376_RS19465	COG0010	Belongs to the arginase family
CS376_RS19470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS376_RS19475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS376_RS19490	COG1994	Peptidase M50
CS376_RS19495	COG1942	4-Oxalocrotonate Tautomerase
CS376_RS19500	COG1846	Transcriptional regulator
CS376_RS19510	COG0531	amino acid
CS376_RS19515	COG3465	dGTPase activity
CS376_RS19520	COG1078	dGTPase activity
CS376_RS19535	COG1695	Transcriptional regulator
CS376_RS19545	COG1131	(ABC) transporter
CS376_RS19550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS376_RS19580	COG0583	DNA-binding transcription factor activity
CS376_RS19585	COG2855	membrane
CS376_RS19590	COG0280	phosphate acetyltransferase
CS376_RS19620	COG3118	belongs to the thioredoxin family
CS376_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS19630	COG0436	Aminotransferase
CS376_RS19660	COG2814	Major facilitator Superfamily
CS376_RS19665	COG2814	Major facilitator Superfamily
CS376_RS19670	COG0833	amino acid
CS376_RS19675	COG4187	Peptidase family M20/M25/M40
CS376_RS19680	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS19685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS376_RS19695	COG0745	RESPONSE REGULATOR receiver
CS376_RS19710	COG1131	(ABC) transporter
CS376_RS19715	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CS376_RS19720	COG1091	dTDP-4-dehydrorhamnose reductase activity
CS376_RS19725	COG1088	dTDP-glucose 4,6-dehydratase activity
CS376_RS19730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CS376_RS19735	COG3980	spore coat polysaccharide biosynthesis protein
CS376_RS19740	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CS376_RS19745	COG2089	acid synthase
CS376_RS19750	COG0456	acetyltransferase
CS376_RS19755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS376_RS19760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CS376_RS19765	COG0463	Glycosyl transferase, family 2
CS376_RS19775	COG2363	Small membrane protein
CS376_RS19780	COG2233	PERMEase
CS376_RS19795	COG1216	Glycosyl transferase, family 2
CS376_RS19810	COG1695	Transcriptional regulator
CS376_RS19815	COG0351	phosphomethylpyrimidine kinase
CS376_RS19825	COG1621	beta-fructofuranosidase activity
CS376_RS19830	COG1263	PTS System
CS376_RS19830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS19835	COG3711	transcriptional antiterminator
CS376_RS19845	COG1404	Belongs to the peptidase S8 family
CS376_RS19850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS376_RS19855	COG0778	Nitroreductase
CS376_RS19860	COG0772	Belongs to the SEDS family
CS376_RS19865	COG0454	-acetyltransferase
CS376_RS19885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS376_RS19890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CS376_RS19895	COG2261	transglycosylase associated protein
CS376_RS19900	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CS376_RS19905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS376_RS19910	COG2246	polysaccharide biosynthetic process
CS376_RS19915	COG1309	transcriptional regulator
CS376_RS19935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS376_RS19940	COG2837	iron assimilation
CS376_RS19955	COG0583	DNA-binding transcription factor activity
CS376_RS19965	COG1346	cytolysis
CS376_RS19970	COG4895	conserved protein (DUF2196)
CS376_RS19980	COG0789	Transcriptional regulator
CS376_RS19985	COG5504	Zn-dependent protease
CS376_RS19990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CS376_RS19995	COG0346	lactoylglutathione lyase activity
CS376_RS20000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS20005	COG1404	Belongs to the peptidase S8 family
CS376_RS20010	COG1442	glycosyl transferase family 8
CS376_RS20020	COG2357	RelA SpoT domain protein
CS376_RS20025	COG1575	Belongs to the MenA family. Type 1 subfamily
CS376_RS20045	COG1696	Membrane protein involved in D-alanine export
CS376_RS20055	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CS376_RS20060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS376_RS20065	COG1486	melibiose metabolic process
CS376_RS20070	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS376_RS20075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS20080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS20085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS376_RS20085	COG3711	transcriptional antiterminator
CS376_RS20100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS20105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS376_RS20115	COG0640	Transcriptional regulator
CS376_RS20120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS376_RS20125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS20130	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS376_RS20135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS376_RS20140	COG2723	6-phospho-beta-galactosidase activity
CS376_RS20145	COG1940	carbohydrate kinase activity
CS376_RS20150	COG1482	cell wall glycoprotein biosynthetic process
CS376_RS20160	COG0753	catalase activity
CS376_RS20165	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CS376_RS20170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS376_RS20175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS376_RS20180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CS376_RS20185	COG4988	ABC transporter
CS376_RS20190	COG1294	oxidase, subunit
CS376_RS20195	COG1271	oxidase subunit
CS376_RS20200	COG3493	citrate carrier protein
CS376_RS20205	COG0726	polysaccharide deacetylase
CS376_RS20210	COG3842	ATPase activity
CS376_RS20215	COG2508	Transcriptional regulator
CS376_RS20220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS20230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS376_RS20240	COG4894	glucomannan catabolic process
CS376_RS20245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CS376_RS20250	COG0500	methyltransferase
CS376_RS20255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS376_RS20270	COG0693	protein deglycase activity
CS376_RS20270	COG0753	catalase activity
CS376_RS20275	COG2851	Citrate transporter
CS376_RS20280	COG2273	Hydrolase Family 16
CS376_RS20285	COG3711	transcriptional antiterminator
CS376_RS20295	COG0513	Belongs to the DEAD box helicase family
CS376_RS20375	COG0697	spore germination
CS376_RS20380	COG0589	response to stress
CS376_RS20385	COG2723	6-phospho-beta-galactosidase activity
CS376_RS20390	COG2190	(PTS) system
CS376_RS20390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS376_RS20390	COG1263	PTS System
CS376_RS20405	COG3507	Belongs to the glycosyl hydrolase 43 family
CS376_RS20430	COG0010	Belongs to the arginase family
CS376_RS20435	COG0833	amino acid
CS376_RS20440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CS376_RS20445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS376_RS20455	COG2390	Transcriptional regulator
CS376_RS20460	COG0561	phosphatase activity
CS376_RS20490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS376_RS20495	COG5294	Protein conserved in bacteria
CS376_RS20500	COG0577	efflux transmembrane transporter activity
CS376_RS20505	COG1136	(ABC) transporter
CS376_RS20510	COG2205	protein histidine kinase activity
CS376_RS20515	COG0745	RESPONSE REGULATOR receiver
CS376_RS20520	COG2205	protein histidine kinase activity
CS376_RS20525	COG0745	RESPONSE REGULATOR receiver
CS376_RS20555	COG1082	Xylose isomerase domain protein TIM barrel
CS376_RS20565	COG2814	Major facilitator Superfamily
CS376_RS20595	COG1349	DNA-binding transcription factor activity
CS376_RS20600	COG0667	Aldo Keto reductase
CS376_RS20605	COG2814	Major facilitator Superfamily
CS376_RS20620	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS20625	COG2197	response regulator
CS376_RS20630	COG4585	Histidine kinase
CS376_RS20635	COG3239	Fatty acid desaturase
CS376_RS20645	COG1309	transcriptional regulator
CS376_RS20650	COG1012	belongs to the aldehyde dehydrogenase family
CS376_RS20655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CS376_RS20665	COG0640	Transcriptional regulator
CS376_RS20670	COG2814	Major facilitator Superfamily
CS376_RS20675	COG1714	RDD family
CS376_RS20685	COG0501	Belongs to the peptidase M48B family
CS376_RS20690	COG1715	Restriction endonuclease
CS376_RS20695	COG0450	alkyl hydroperoxide reductase
CS376_RS20700	COG3634	alkyl hydroperoxide reductase activity
CS376_RS20705	COG3177	Filamentation induced by cAMP protein fic
CS376_RS20720	COG2080	2 iron, 2 sulfur cluster binding
CS376_RS20735	COG2068	MobA-Related Protein
CS376_RS20790	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CS376_RS20795	COG0667	Aldo Keto reductase
CS376_RS20800	COG0456	acetyltransferase
CS376_RS20805	COG0457	Tetratricopeptide repeat
CS376_RS20810	COG0010	Belongs to the arginase family
CS376_RS20815	COG0833	amino acid
CS376_RS20820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS376_RS20825	COG5658	integral membrane protein
CS376_RS20830	COG0640	Transcriptional regulator
CS376_RS20835	COG3829	transcription factor binding
CS376_RS20845	COG0488	(ABC) transporter
CS376_RS20860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS376_RS20865	COG3850	Histidine kinase
CS376_RS20865	COG5002	protein histidine kinase activity
CS376_RS20870	COG0745	RESPONSE REGULATOR receiver
CS376_RS20875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS376_RS20880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS376_RS20885	COG4853	Protein conserved in bacteria
CS376_RS20890	COG4863	YycH protein
CS376_RS20895	COG5002	protein histidine kinase activity
CS376_RS20900	COG0745	RESPONSE REGULATOR receiver
CS376_RS20935	COG0346	lactoylglutathione lyase activity
CS376_RS20940	COG0305	Participates in initiation and elongation during chromosome replication
CS376_RS20960	COG3093	addiction module antidote protein HigA
CS376_RS20965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CS376_RS20980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CS376_RS20985	COG0438	transferase activity, transferring glycosyl groups
CS376_RS21005	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CS376_RS21010	COG4241	membrane
CS376_RS21020	COG5577	PFAM Coat F domain
CS376_RS21025	COG1733	regulation of RNA biosynthetic process
CS376_RS21035	COG0697	spore germination
CS376_RS21040	COG1621	beta-fructofuranosidase activity
CS376_RS21045	COG1621	beta-fructofuranosidase activity
CS376_RS21050	COG1802	Transcriptional regulator
CS376_RS21055	COG2318	DinB family
CS376_RS21060	COG2211	Major facilitator Superfamily
CS376_RS21065	COG0583	DNA-binding transcription factor activity
CS376_RS21075	COG2814	Major facilitator Superfamily
CS376_RS21080	COG0583	DNA-binding transcription factor activity
CS376_RS21090	COG0778	Nitroreductase
CS376_RS21095	COG1846	Transcriptional regulator
CS376_RS21100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS376_RS21105	COG1846	Transcriptional regulator
CS376_RS21110	COG2153	protein acetylation
CS376_RS21120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CS376_RS21125	COG0583	DNA-binding transcription factor activity
CS376_RS21130	COG1028	Short-chain dehydrogenase reductase Sdr
CS376_RS21135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS376_RS21140	COG0697	spore germination
CS376_RS21145	COG1331	Highly conserved protein containing a thioredoxin domain
CS376_RS21150	COG1266	CAAX protease self-immunity
CS376_RS21155	COG0477	Major facilitator Superfamily
CS376_RS21155	COG2814	Major facilitator Superfamily
CS376_RS21160	COG0346	lactoylglutathione lyase activity
CS376_RS21165	COG1609	Transcriptional regulator
CS376_RS21170	COG0708	Exodeoxyribonuclease III
CS376_RS21175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS376_RS21180	COG2169	Transcriptional regulator
CS376_RS21190	COG0629	single-stranded DNA binding
CS376_RS21200	COG0012	GTP binding
CS376_RS21205	COG0243	molybdopterin cofactor binding
CS376_RS21210	COG4481	Protein conserved in bacteria
CS376_RS21215	COG3949	Membrane
CS376_RS21230	COG1475	DNA binding
CS376_RS21235	COG1192	Involved in chromosome partitioning
CS376_RS21260	COG1847	R3H domain protein
CS376_RS21265	COG0706	membrane insertase activity