locus-tag	class	description
NRF13_RS00010	COG2814	Major facilitator Superfamily
NRF13_RS00015	COG0697	spore germination
NRF13_RS00020	COG0789	Transcriptional regulator
NRF13_RS00025	COG0583	DNA-binding transcription factor activity
NRF13_RS00095	COG0592	DNA-directed DNA polymerase activity
NRF13_RS00100	COG2501	S4 domain
NRF13_RS00115	COG0187	DNA topoisomerase II activity
NRF13_RS00120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NRF13_RS00155	COG0516	GMP reductase activity
NRF13_RS00155	COG0517	IMP dehydrogenase activity
NRF13_RS00160	COG1686	Belongs to the peptidase S11 family
NRF13_RS00180	COG1929	Belongs to the glycerate kinase type-1 family
NRF13_RS00190	COG1428	Deoxynucleoside kinase
NRF13_RS00195	COG1428	Deoxynucleoside kinase
NRF13_RS00200	COG1388	LysM domain
NRF13_RS00200	COG3858	chitin binding
NRF13_RS00205	COG1335	isochorismatase
NRF13_RS00210	COG0590	tRNA wobble adenosine to inosine editing
NRF13_RS00220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NRF13_RS00225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRF13_RS00275	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NRF13_RS00280	COG3853	Toxic anion resistance protein (TelA)
NRF13_RS00285	COG1982	Orn Lys Arg decarboxylase major
NRF13_RS00295	COG3870	Protein conserved in bacteria
NRF13_RS00300	COG1728	Protein conserved in bacteria
NRF13_RS00305	COG0470	DNA polymerase III
NRF13_RS00310	COG1774	PSP1 C-terminal conserved region
NRF13_RS00320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NRF13_RS00330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NRF13_RS00335	COG2002	toxin-antitoxin pair type II binding
NRF13_RS00340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRF13_RS00340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRF13_RS00345	COG0084	hydrolase, TatD family'
NRF13_RS00350	COG3583	domain protein
NRF13_RS00350	COG3584	3D domain protein
NRF13_RS00355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NRF13_RS00360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRF13_RS00370	COG4466	Protein conserved in bacteria
NRF13_RS00385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRF13_RS00390	COG0251	oxidation-reduction process
NRF13_RS00405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRF13_RS00425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NRF13_RS00430	COG2002	toxin-antitoxin pair type II binding
NRF13_RS00435	COG2244	polysaccharide biosynthetic process
NRF13_RS00440	COG3956	TIGRFAM MazG family protein
NRF13_RS00445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NRF13_RS00460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NRF13_RS00465	COG1098	S1 RNA binding domain
NRF13_RS00480	COG2208	phosphoserine phosphatase activity
NRF13_RS00485	COG2304	oxidoreductase activity
NRF13_RS00490	COG0515	serine threonine protein kinase
NRF13_RS00495	COG0037	tRNA processing
NRF13_RS00500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NRF13_RS00505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NRF13_RS00520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRF13_RS00525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRF13_RS00530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRF13_RS00535	COG0512	Glutamine amidotransferase of anthranilate synthase
NRF13_RS00540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS00545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRF13_RS00550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRF13_RS00555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NRF13_RS00560	COG1396	sequence-specific DNA binding
NRF13_RS00565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRF13_RS00570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRF13_RS00650	COG4463	regulation of RNA biosynthetic process
NRF13_RS00655	COG3880	PFAM UvrB UvrC protein
NRF13_RS00665	COG0542	response to heat
NRF13_RS00680	COG1132	(ABC) transporter
NRF13_RS00690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NRF13_RS00695	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NRF13_RS00700	COG4956	integral membrane protein (PIN domain superfamily)
NRF13_RS00720	COG1045	serine acetyltransferase
NRF13_RS00730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NRF13_RS00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRF13_RS00740	COG3688	RNA-binding protein containing a PIN domain
NRF13_RS00745	COG1595	DNA-templated transcription, initiation
NRF13_RS00755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRF13_RS00760	COG0250	Participates in transcription elongation, termination and antitermination
NRF13_RS00785	COG2813	Specifically methylates the guanine in position
NRF13_RS00800	COG1358	cellular component organization or biogenesis
NRF13_RS00825	COG0596	Alpha beta hydrolase
NRF13_RS00935	COG0201	protein transport
NRF13_RS00945	COG0024	Methionine aminopeptidase
NRF13_RS00960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRF13_RS00985	COG1122	ATPase activity
NRF13_RS00990	COG1122	ATPase activity
NRF13_RS00995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NRF13_RS01015	COG2226	methyltransferase
NRF13_RS01020	COG2318	DinB family
NRF13_RS01030	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS01035	COG0489	protein tyrosine kinase activity
NRF13_RS01045	COG2194	sulfuric ester hydrolase activity
NRF13_RS01050	COG0726	polysaccharide deacetylase
NRF13_RS01110	COG0738	Major facilitator superfamily
NRF13_RS01115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS01130	COG0659	secondary active sulfate transmembrane transporter activity
NRF13_RS01135	COG0385	Bile acid
NRF13_RS01140	COG2819	hydrolase of the alpha beta superfamily
NRF13_RS01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS01150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS01155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRF13_RS01160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRF13_RS01160	COG2207	Transcriptional regulator
NRF13_RS01165	COG3876	Protein conserved in bacteria
NRF13_RS01170	COG1472	Belongs to the glycosyl hydrolase 3 family
NRF13_RS01175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRF13_RS01180	COG1263	PTS System
NRF13_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS01190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRF13_RS01195	COG1683	Conserved Protein
NRF13_RS01225	COG1595	DNA-templated transcription, initiation
NRF13_RS01230	COG5662	AntiSigma factor
NRF13_RS01235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NRF13_RS01240	COG4856	YbbR-like protein
NRF13_RS01280	COG1346	cytolysis
NRF13_RS01285	COG1380	Effector of murein hydrolase LrgA
NRF13_RS01290	COG1846	Transcriptional regulator
NRF13_RS01295	COG1113	amino acid transport
NRF13_RS01300	COG1011	Hydrolase
NRF13_RS01305	COG4585	Histidine kinase
NRF13_RS01310	COG2197	response regulator
NRF13_RS01315	COG1131	(ABC) transporter
NRF13_RS01355	COG0531	amino acid
NRF13_RS01360	COG0584	glycerophosphoryl diester phosphodiesterase
NRF13_RS01365	COG2271	Major facilitator Superfamily
NRF13_RS01375	COG2368	4-hydroxyphenylacetate
NRF13_RS01385	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS01400	COG0371	Dehydrogenase
NRF13_RS01410	COG1183	phosphatidylcholine synthase activity
NRF13_RS01415	COG0586	Pfam SNARE associated Golgi protein
NRF13_RS01420	COG0688	phosphatidylethanolamine metabolic process
NRF13_RS01435	COG1301	dicarboxylic acid transport
NRF13_RS01440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS01445	COG0833	amino acid
NRF13_RS01450	COG2040	homocysteine
NRF13_RS01455	COG1115	amino acid carrier protein
NRF13_RS01460	COG2066	Belongs to the glutaminase family
NRF13_RS01465	COG4191	Histidine kinase
NRF13_RS01470	COG0784	Response regulator, receiver
NRF13_RS01475	COG3173	Aminoglycoside phosphotransferase
NRF13_RS01485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NRF13_RS01490	COG0778	Nitroreductase
NRF13_RS01495	COG0346	lactoylglutathione lyase activity
NRF13_RS01500	COG2259	Doxx family
NRF13_RS01505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS01520	COG3773	Cell wall hydrolase
NRF13_RS01525	COG3540	Alkaline phosphatase
NRF13_RS01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRF13_RS01535	COG0805	protein transport
NRF13_RS01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRF13_RS01550	COG0477	Major facilitator Superfamily
NRF13_RS01555	COG1309	transcriptional regulator
NRF13_RS01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NRF13_RS01570	COG3012	SEC-C Motif Domain Protein
NRF13_RS01570	COG1405	negative regulation of cell septum assembly
NRF13_RS01575	COG0667	Aldo Keto reductase
NRF13_RS01585	COG1595	DNA-templated transcription, initiation
NRF13_RS01590	COG1595	DNA-templated transcription, initiation
NRF13_RS01595	COG1876	peptidase activity
NRF13_RS01600	COG0457	Tetratricopeptide repeat
NRF13_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS01610	COG0366	Alpha amylase catalytic
NRF13_RS01615	COG0803	Belongs to the bacterial solute-binding protein 9 family
NRF13_RS01620	COG1121	(ABC) transporter
NRF13_RS01625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRF13_RS01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS01635	COG2310	stress, protein
NRF13_RS01640	COG2310	stress, protein
NRF13_RS01645	COG2310	stress, protein
NRF13_RS01650	COG0861	Integral membrane protein TerC family
NRF13_RS01660	COG3853	Toxic anion resistance protein (TelA)
NRF13_RS01665	COG0477	Major facilitator Superfamily
NRF13_RS01670	COG4175	Glycine betaine
NRF13_RS01670	COG0517	IMP dehydrogenase activity
NRF13_RS01675	COG4176	ABC-type proline glycine betaine transport system permease component
NRF13_RS01680	COG2113	Glycine betaine
NRF13_RS01685	COG1473	amidohydrolase
NRF13_RS01690	COG1288	antiporter activity
NRF13_RS01700	COG0366	Alpha amylase catalytic
NRF13_RS01710	COG2814	Major facilitator Superfamily
NRF13_RS01715	COG1846	Transcriptional regulator
NRF13_RS01720	COG1280	lysine exporter protein (LysE YggA)
NRF13_RS01725	COG3403	YqcI/YcgG family
NRF13_RS01730	COG1113	amino acid transport
NRF13_RS01735	COG3665	Urea carboxylase-associated protein
NRF13_RS01750	COG1660	Displays ATPase and GTPase activities
NRF13_RS01760	COG2271	Major facilitator Superfamily
NRF13_RS01765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRF13_RS01770	COG3458	cephalosporin-C deacetylase activity
NRF13_RS01775	COG3541	Predicted nucleotidyltransferase
NRF13_RS01780	COG0506	proline dehydrogenase activity
NRF13_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS01790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRF13_RS01795	COG2508	Transcriptional regulator
NRF13_RS01805	COG1587	Uroporphyrinogen-III synthase
NRF13_RS01805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRF13_RS01810	COG2146	nitrite reductase [NAD(P)H] activity
NRF13_RS01815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRF13_RS01825	COG0523	cobalamin synthesis protein
NRF13_RS01830	COG1063	alcohol dehydrogenase
NRF13_RS01835	COG1714	RDD family
NRF13_RS01845	COG2723	6-phospho-beta-galactosidase activity
NRF13_RS01860	COG3209	COG3209 Rhs family protein
NRF13_RS01865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NRF13_RS01870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NRF13_RS01875	COG1733	regulation of RNA biosynthetic process
NRF13_RS01880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS01900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS01905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS01910	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NRF13_RS01925	COG2364	Membrane
NRF13_RS01930	COG1126	abc transporter atp-binding protein
NRF13_RS01935	COG0765	amino acid transport
NRF13_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS01945	COG0583	DNA-binding transcription factor activity
NRF13_RS01950	COG0163	prenyltransferase activity
NRF13_RS01955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRF13_RS01970	COG3104	oligopeptide transport
NRF13_RS01975	COG5434	Belongs to the glycosyl hydrolase 28 family
NRF13_RS01985	COG0697	spore germination
NRF13_RS01995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NRF13_RS02000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS02005	COG0456	acetyltransferase
NRF13_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS02015	COG0765	amino acid transport
NRF13_RS02020	COG1126	abc transporter atp-binding protein
NRF13_RS02025	COG1473	amidohydrolase
NRF13_RS02030	COG2079	MmgE PrpD family protein
NRF13_RS02035	COG1136	(ABC) transporter
NRF13_RS02040	COG0577	efflux transmembrane transporter activity
NRF13_RS02045	COG0745	RESPONSE REGULATOR receiver
NRF13_RS02050	COG5002	protein histidine kinase activity
NRF13_RS02050	COG3850	Histidine kinase
NRF13_RS02055	COG0457	Tetratricopeptide repeat
NRF13_RS02070	COG0527	aspartate kinase activity
NRF13_RS02075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS02080	COG4605	iron ion homeostasis
NRF13_RS02085	COG4604	ABC transporter, ATP-binding protein
NRF13_RS02090	COG4607	ABC-type enterochelin transport system periplasmic component
NRF13_RS02095	COG2814	Major facilitator Superfamily
NRF13_RS02100	COG1309	transcriptional regulator
NRF13_RS02105	COG0778	Nitroreductase
NRF13_RS02110	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NRF13_RS02115	COG0640	Transcriptional regulator
NRF13_RS02120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS02125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS02130	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS02135	COG4975	Glucose uptake
NRF13_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS02145	COG4549	nuclear export factor GLE1
NRF13_RS02150	COG2372	response to copper ion
NRF13_RS02150	COG1276	copper resistance
NRF13_RS02155	COG1349	DNA-binding transcription factor activity
NRF13_RS02165	COG2213	PTS system mannitol-specific
NRF13_RS02170	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS02180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NRF13_RS02190	COG0561	phosphatase activity
NRF13_RS02200	COG1914	H( )-stimulated, divalent metal cation uptake system
NRF13_RS02210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NRF13_RS02215	COG1984	allophanate hydrolase subunit 2
NRF13_RS02220	COG1414	Transcriptional regulator
NRF13_RS02225	COG2755	lipolytic protein G-D-S-L family
NRF13_RS02235	COG2329	Antibiotic biosynthesis monooxygenase
NRF13_RS02240	COG0768	penicillin binding
NRF13_RS02245	COG4989	oxidoreductase activity
NRF13_RS02250	COG3711	transcriptional antiterminator
NRF13_RS02255	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS02265	COG1917	Cupin 2, conserved barrel domain protein
NRF13_RS02270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRF13_RS02275	COG3871	stress protein (general stress protein 26)
NRF13_RS02285	COG2814	Major facilitator Superfamily
NRF13_RS02290	COG1522	sequence-specific DNA binding
NRF13_RS02295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRF13_RS02295	COG0551	DNA topoisomerase type I activity
NRF13_RS02300	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NRF13_RS02305	COG3706	GGDEF domain
NRF13_RS02310	COG5298	Protein conserved in bacteria
NRF13_RS02315	COG1215	transferase activity, transferring glycosyl groups
NRF13_RS02325	COG0531	amino acid
NRF13_RS02330	COG0494	nUDIX hydrolase
NRF13_RS02335	COG0028	Belongs to the TPP enzyme family
NRF13_RS02385	COG0457	Tetratricopeptide repeat
NRF13_RS02415	COG1914	H( )-stimulated, divalent metal cation uptake system
NRF13_RS02435	COG2076	Multidrug Resistance protein
NRF13_RS02440	COG2217	Heavy metal translocating P-type atpase
NRF13_RS02445	COG3729	General stress protein
NRF13_RS02450	COG0662	Cupin 2, conserved barrel domain protein
NRF13_RS02455	COG2329	Antibiotic biosynthesis monooxygenase
NRF13_RS02460	COG3546	catalase activity
NRF13_RS02465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NRF13_RS02470	COG3290	protein histidine kinase activity
NRF13_RS02475	COG4565	transcriptional regulatory protein
NRF13_RS02480	COG1301	dicarboxylic acid transport
NRF13_RS02485	COG0628	permease
NRF13_RS02490	COG1131	(ABC) transporter
NRF13_RS02495	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NRF13_RS02505	COG1960	acyl-CoA dehydrogenase activity
NRF13_RS02520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NRF13_RS02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS02535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NRF13_RS02540	COG0513	Belongs to the DEAD box helicase family
NRF13_RS02545	COG3402	PFAM membrane-flanked domain
NRF13_RS02550	COG3428	Bacterial PH domain
NRF13_RS02555	COG0705	Rhomboid family
NRF13_RS02565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NRF13_RS02570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRF13_RS02575	COG0864	Transcriptional regulator
NRF13_RS02580	COG2337	Toxic component of a toxin-antitoxin (TA) module
NRF13_RS02585	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS02590	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS02595	COG2172	sigma factor antagonist activity
NRF13_RS02600	COG2208	phosphoserine phosphatase activity
NRF13_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS02615	COG1191	sigma factor activity
NRF13_RS02620	COG2208	phosphoserine phosphatase activity
NRF13_RS02625	COG2183	response to ionizing radiation
NRF13_RS02680	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRF13_RS02700	COG0477	Major facilitator Superfamily
NRF13_RS02710	COG1764	response to oxidative stress
NRF13_RS02715	COG1846	Transcriptional regulator
NRF13_RS02725	COG1959	2 iron, 2 sulfur cluster binding
NRF13_RS02730	COG2910	NAD(P)H-binding
NRF13_RS02735	COG1278	Cold shock
NRF13_RS02745	COG1937	Protein conserved in bacteria
NRF13_RS02750	COG2210	Belongs to the sulfur carrier protein TusA family
NRF13_RS02760	COG0425	Belongs to the sulfur carrier protein TusA family
NRF13_RS02760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRF13_RS02770	COG0425	Belongs to the sulfur carrier protein TusA family
NRF13_RS02775	COG0730	response to heat
NRF13_RS02780	COG1794	racemase activity, acting on amino acids and derivatives
NRF13_RS02795	COG3621	Patatin-like phospholipase
NRF13_RS02805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRF13_RS02810	COG1802	Transcriptional regulator
NRF13_RS02815	COG0251	oxidation-reduction process
NRF13_RS02820	COG0814	amino acid
NRF13_RS02825	COG1473	amidohydrolase
NRF13_RS02830	COG2207	Transcriptional regulator
NRF13_RS02830	COG1917	Cupin 2, conserved barrel domain protein
NRF13_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS02845	COG0477	Major facilitator Superfamily
NRF13_RS02865	COG0277	FAD linked oxidase domain protein
NRF13_RS02900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRF13_RS02925	COG1064	alcohol dehydrogenase
NRF13_RS02930	COG0789	Transcriptional regulator
NRF13_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS02955	COG2814	Major facilitator Superfamily
NRF13_RS02960	COG1309	transcriptional regulator
NRF13_RS02965	COG5577	PFAM Coat F domain
NRF13_RS02975	COG1063	alcohol dehydrogenase
NRF13_RS02980	COG5577	PFAM Coat F domain
NRF13_RS02990	COG4585	Histidine kinase
NRF13_RS02995	COG2197	response regulator
NRF13_RS03000	COG2409	Drug exporters of the RND superfamily
NRF13_RS03005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRF13_RS03010	COG0488	(ABC) transporter
NRF13_RS03015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRF13_RS03020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS03030	COG2814	Major facilitator Superfamily
NRF13_RS03035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRF13_RS03045	COG0730	response to heat
NRF13_RS03050	COG0456	acetyltransferase
NRF13_RS03055	COG0789	Transcriptional regulator
NRF13_RS03055	COG4978	Transcriptional regulator
NRF13_RS03060	COG0697	spore germination
NRF13_RS03065	COG1051	belongs to the nudix hydrolase family
NRF13_RS03070	COG2226	methyltransferase
NRF13_RS03075	COG0473	3-isopropylmalate dehydrogenase activity
NRF13_RS03080	COG1802	Transcriptional regulator
NRF13_RS03085	COG1819	glycosyl
NRF13_RS03100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRF13_RS03110	COG1388	LysM domain
NRF13_RS03115	COG2814	Major facilitator Superfamily
NRF13_RS03120	COG2188	Transcriptional regulator
NRF13_RS03125	COG2186	Transcriptional regulator
NRF13_RS03130	COG2807	transmembrane transport
NRF13_RS03135	COG2076	Multidrug Resistance protein
NRF13_RS03140	COG2076	Multidrug Resistance protein
NRF13_RS03145	COG1309	transcriptional regulator
NRF13_RS03150	COG0531	amino acid
NRF13_RS03160	COG3832	glyoxalase III activity
NRF13_RS03165	COG0604	alcohol dehydrogenase
NRF13_RS03170	COG2814	Major facilitator Superfamily
NRF13_RS03210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NRF13_RS03215	COG0802	atpase or kinase
NRF13_RS03220	COG1214	PFAM Peptidase M22, glycoprotease
NRF13_RS03225	COG0456	acetyltransferase
NRF13_RS03230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRF13_RS03235	COG0488	(ABC) transporter
NRF13_RS03250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRF13_RS03255	COG0805	protein transport
NRF13_RS03265	COG1266	CAAX protease self-immunity
NRF13_RS03290	COG0457	Tetratricopeptide repeat
NRF13_RS03295	COG1063	alcohol dehydrogenase
NRF13_RS03300	COG2211	Major facilitator Superfamily
NRF13_RS03305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRF13_RS03315	COG1842	Phage shock protein A
NRF13_RS03320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRF13_RS03325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NRF13_RS03330	COG4260	virion core protein, lumpy skin disease virus
NRF13_RS03335	COG2755	lipolytic protein G-D-S-L family
NRF13_RS03335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NRF13_RS03345	COG1595	DNA-templated transcription, initiation
NRF13_RS03350	COG1063	alcohol dehydrogenase
NRF13_RS03355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NRF13_RS03360	COG0823	Involved in the tonB-independent uptake of proteins
NRF13_RS03375	COG2132	Multicopper oxidase
NRF13_RS03380	COG1113	amino acid transport
NRF13_RS03385	COG0714	Associated with various cellular activities
NRF13_RS03390	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NRF13_RS03395	COG1305	Transglutaminase-like
NRF13_RS03415	COG2252	PERMEase
NRF13_RS03420	COG3064	Membrane
NRF13_RS03440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRF13_RS03445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NRF13_RS03450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRF13_RS03455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRF13_RS03460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRF13_RS03475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NRF13_RS03485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NRF13_RS03490	COG0138	bifunctional purine biosynthesis protein purh
NRF13_RS03495	COG0151	Belongs to the GarS family
NRF13_RS03505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NRF13_RS03510	COG1470	cell adhesion involved in biofilm formation
NRF13_RS03515	COG4496	protein, YerC YecD
NRF13_RS03520	COG0069	glutamate synthase activity
NRF13_RS03530	COG0210	DNA helicase
NRF13_RS03540	COG4851	CamS sex pheromone cAM373 precursor
NRF13_RS03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRF13_RS03550	COG1285	pathogenesis
NRF13_RS03555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRF13_RS03575	COG1309	transcriptional regulator
NRF13_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRF13_RS03585	COG1597	lipid kinase activity
NRF13_RS03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRF13_RS03595	COG2197	response regulator
NRF13_RS03605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS03615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRF13_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS03630	COG1131	(ABC) transporter
NRF13_RS03685	COG3546	catalase activity
NRF13_RS03690	COG0454	-acetyltransferase
NRF13_RS03700	COG2323	membrane
NRF13_RS03705	COG2329	Antibiotic biosynthesis monooxygenase
NRF13_RS03710	COG0346	lactoylglutathione lyase activity
NRF13_RS03715	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS03720	COG5583	Uncharacterized small protein (DUF2292)
NRF13_RS03725	COG0196	riboflavin kinase activity
NRF13_RS03730	COG0670	Belongs to the BI1 family
NRF13_RS03740	COG1846	Transcriptional regulator
NRF13_RS03745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRF13_RS03755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRF13_RS03755	COG2124	cytochrome p450
NRF13_RS03770	COG1131	(ABC) transporter
NRF13_RS03780	COG1368	sulfuric ester hydrolase activity
NRF13_RS03785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRF13_RS03790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS03795	COG1442	glycosyl transferase family 8
NRF13_RS03800	COG1216	Glycosyl transferase, family 2
NRF13_RS03805	COG1442	glycosyl transferase family 8
NRF13_RS03810	COG2223	nitrite transmembrane transporter activity
NRF13_RS03815	COG0531	amino acid
NRF13_RS03820	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS03825	COG0840	transmembrane signaling receptor activity
NRF13_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS03835	COG0463	Glycosyl transferase, family 2
NRF13_RS03835	COG0457	Tetratricopeptide repeat
NRF13_RS03840	COG0488	(ABC) transporter
NRF13_RS03845	COG0789	Transcriptional regulator
NRF13_RS03850	COG2814	Major facilitator Superfamily
NRF13_RS03855	COG0488	(ABC) transporter
NRF13_RS03860	COG0513	Belongs to the DEAD box helicase family
NRF13_RS03870	COG2130	NADP-dependent
NRF13_RS03885	COG3866	Pectate lyase
NRF13_RS03890	COG0471	metal ion transport
NRF13_RS03925	COG2972	Histidine kinase
NRF13_RS03925	COG0745	RESPONSE REGULATOR receiver
NRF13_RS03935	COG3279	Response regulator of the LytR AlgR family
NRF13_RS03945	COG3764	Sortase (surface protein transpeptidase)
NRF13_RS03950	COG3290	protein histidine kinase activity
NRF13_RS03955	COG4565	transcriptional regulatory protein
NRF13_RS03960	COG3181	Tripartite tricarboxylate transporter family receptor
NRF13_RS03965	COG2851	Citrate transporter
NRF13_RS03970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS03975	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NRF13_RS03985	COG2258	MOSC domain
NRF13_RS04005	COG0024	Methionine aminopeptidase
NRF13_RS04010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS04010	COG1263	PTS System
NRF13_RS04020	COG1368	sulfuric ester hydrolase activity
NRF13_RS04030	COG0071	Belongs to the small heat shock protein (HSP20) family
NRF13_RS04045	COG1263	PTS System
NRF13_RS04045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS04050	COG0366	Alpha amylase catalytic
NRF13_RS04055	COG2188	Transcriptional regulator
NRF13_RS04060	COG0778	Nitroreductase
NRF13_RS04075	COG0737	Belongs to the 5'-nucleotidase family
NRF13_RS04080	COG0693	protein deglycase activity
NRF13_RS04085	COG1609	Transcriptional regulator
NRF13_RS04100	COG2814	Major facilitator Superfamily
NRF13_RS04110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRF13_RS04115	COG4980	gas vesicle protein
NRF13_RS04120	COG1295	ribonuclease BN
NRF13_RS04125	COG0477	Major facilitator Superfamily
NRF13_RS04130	COG0387	Pfam Sodium calcium exchanger
NRF13_RS04140	COG0668	transmembrane transport
NRF13_RS04145	COG0535	radical SAM domain protein
NRF13_RS04155	COG0726	polysaccharide deacetylase
NRF13_RS04160	COG2084	Dehydrogenase
NRF13_RS04170	COG0598	Magnesium transport protein CorA
NRF13_RS04175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NRF13_RS04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRF13_RS04190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NRF13_RS04195	COG4637	Psort location Cytoplasmic, score
NRF13_RS04200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NRF13_RS04205	COG0022	dehydrogenase e1 component
NRF13_RS04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRF13_RS04215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRF13_RS04220	COG3284	Transcriptional regulator
NRF13_RS04230	COG1486	melibiose metabolic process
NRF13_RS04235	COG1737	Transcriptional regulator
NRF13_RS04240	COG1263	PTS System
NRF13_RS04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS04245	COG1132	(ABC) transporter
NRF13_RS04250	COG1132	(ABC) transporter
NRF13_RS04255	COG2259	Doxx family
NRF13_RS04260	COG2514	catechol 2,3-dioxygenase activity
NRF13_RS04270	COG1695	Transcriptional regulator
NRF13_RS04275	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRF13_RS04280	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NRF13_RS04285	COG0574	Belongs to the PEP-utilizing enzyme family
NRF13_RS04285	COG3848	Pyruvate phosphate dikinase
NRF13_RS04290	COG2732	(Barnase) inhibitor
NRF13_RS04295	COG2318	DinB family
NRF13_RS04300	COG2814	Major facilitator Superfamily
NRF13_RS04305	COG1846	Transcriptional regulator
NRF13_RS04310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRF13_RS04310	COG0392	lysyltransferase activity
NRF13_RS04315	COG0384	phenazine biosynthesis protein PhzF
NRF13_RS04320	COG0778	Nitroreductase
NRF13_RS04335	COG1090	epimerase
NRF13_RS04350	COG2814	Major facilitator Superfamily
NRF13_RS04360	COG3591	Belongs to the peptidase S1B family
NRF13_RS04375	COG3103	Sh3 type 3 domain protein
NRF13_RS04380	COG5658	integral membrane protein
NRF13_RS04385	COG0596	Alpha beta hydrolase
NRF13_RS04390	COG0463	Glycosyl transferase, family 2
NRF13_RS04395	COG4485	Bacterial membrane protein, YfhO
NRF13_RS04400	COG1988	membrane-bound metal-dependent
NRF13_RS04405	COG1194	a g-specific adenine glycosylase
NRF13_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS04435	COG1132	(ABC) transporter
NRF13_RS04440	COG4129	membrane
NRF13_RS04450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NRF13_RS04455	COG0735	belongs to the Fur family
NRF13_RS04570	COG3340	Belongs to the peptidase S51 family
NRF13_RS04580	COG0277	FAD linked oxidase domain protein
NRF13_RS04590	COG0747	negative chemotaxis
NRF13_RS04595	COG0601	transmembrane transport
NRF13_RS04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRF13_RS04605	COG0444	Belongs to the ABC transporter superfamily
NRF13_RS04610	COG4608	Belongs to the ABC transporter superfamily
NRF13_RS04615	COG0753	catalase activity
NRF13_RS04625	COG1116	anion transmembrane transporter activity
NRF13_RS04630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NRF13_RS04635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRF13_RS04655	COG1476	TRANSCRIPTIONal
NRF13_RS04665	COG3382	B3 4 domain protein
NRF13_RS04670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NRF13_RS04680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NRF13_RS04685	COG0789	Transcriptional regulator
NRF13_RS04690	COG1664	Polymer-forming cytoskeletal
NRF13_RS04695	COG1664	Polymer-forming cytoskeletal
NRF13_RS04700	COG2766	serine protein kinase
NRF13_RS04710	COG1846	Transcriptional regulator
NRF13_RS04715	COG1566	PFAM secretion protein HlyD family protein
NRF13_RS04720	COG2814	Major facilitator Superfamily
NRF13_RS04725	COG0655	NAD(P)H dehydrogenase (quinone) activity
NRF13_RS04740	COG1725	Transcriptional regulator
NRF13_RS04745	COG1131	(ABC) transporter
NRF13_RS04750	COG1131	(ABC) transporter
NRF13_RS04755	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NRF13_RS04760	COG1278	Cold shock
NRF13_RS04765	COG1464	Belongs to the NlpA lipoprotein family
NRF13_RS04770	COG3706	GGDEF domain
NRF13_RS04775	COG1823	symporter activity
NRF13_RS04795	COG5577	PFAM Coat F domain
NRF13_RS04800	COG0737	Belongs to the 5'-nucleotidase family
NRF13_RS04800	COG4085	toxin activity
NRF13_RS04800	COG1525	nuclease
NRF13_RS04805	COG3764	Sortase (surface protein transpeptidase)
NRF13_RS04810	COG0564	pseudouridine synthase activity
NRF13_RS04820	COG0517	IMP dehydrogenase activity
NRF13_RS04825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRF13_RS04830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRF13_RS04830	COG3153	acetyltransferase
NRF13_RS04835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRF13_RS04840	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NRF13_RS04845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRF13_RS04855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRF13_RS04860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRF13_RS04875	COG0431	NADPH-dependent FMN reductase
NRF13_RS04890	COG0791	NLP P60 protein
NRF13_RS04890	COG1388	LysM domain
NRF13_RS04895	COG1959	2 iron, 2 sulfur cluster binding
NRF13_RS04900	COG0668	transmembrane transport
NRF13_RS04905	COG2719	SpoVR family
NRF13_RS04910	COG1785	Belongs to the alkaline phosphatase family
NRF13_RS04915	COG1388	LysM domain
NRF13_RS04915	COG0791	NLP P60 protein
NRF13_RS04920	COG0583	DNA-binding transcription factor activity
NRF13_RS04925	COG0372	Belongs to the citrate synthase family
NRF13_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS04935	COG0531	amino acid
NRF13_RS04940	COG0733	neurotransmitter:sodium symporter activity
NRF13_RS04955	COG1595	DNA-templated transcription, initiation
NRF13_RS04960	COG0204	Acyl-transferase
NRF13_RS04965	COG1253	flavin adenine dinucleotide binding
NRF13_RS04970	COG0789	Transcriptional regulator
NRF13_RS04975	COG0436	Aminotransferase
NRF13_RS04980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRF13_RS04985	COG1253	flavin adenine dinucleotide binding
NRF13_RS04990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRF13_RS04995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRF13_RS05000	COG0584	glycerophosphoryl diester phosphodiesterase
NRF13_RS05010	COG0668	transmembrane transport
NRF13_RS05015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NRF13_RS05020	COG0726	polysaccharide deacetylase
NRF13_RS05025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS05030	COG3226	Transcriptional regulator
NRF13_RS05040	COG0589	response to stress
NRF13_RS05045	COG1132	(ABC) transporter
NRF13_RS05050	COG1132	(ABC) transporter
NRF13_RS05055	COG0702	epimerase
NRF13_RS05075	COG0189	ligase activity
NRF13_RS05080	COG0189	ligase activity
NRF13_RS05095	COG4335	DNA alkylation repair
NRF13_RS05100	COG0561	phosphatase activity
NRF13_RS05105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRF13_RS05115	COG0475	glutathione-regulated potassium exporter activity
NRF13_RS05120	COG0490	domain, Protein
NRF13_RS05130	COG1024	Enoyl-CoA hydratase
NRF13_RS05140	COG4152	abc transporter atp-binding protein
NRF13_RS05145	COG1668	transmembrane transport
NRF13_RS05150	COG0420	3'-5' exonuclease activity
NRF13_RS05155	COG4717	serine-type aminopeptidase activity
NRF13_RS05170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NRF13_RS05205	COG4980	gas vesicle protein
NRF13_RS05220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRF13_RS05225	COG0537	adenosine 5'-monophosphoramidase activity
NRF13_RS05230	COG1131	(ABC) transporter
NRF13_RS05235	COG4473	ABC transporter
NRF13_RS05245	COG1473	amidohydrolase
NRF13_RS05250	COG3069	C4-dicarboxylate transmembrane transporter activity
NRF13_RS05255	COG2329	Antibiotic biosynthesis monooxygenase
NRF13_RS05260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRF13_RS05270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRF13_RS05275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NRF13_RS05280	COG1309	transcriptional regulator
NRF13_RS05285	COG1511	domain protein
NRF13_RS05290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRF13_RS05300	COG1363	Peptidase, m42
NRF13_RS05305	COG1301	dicarboxylic acid transport
NRF13_RS05315	COG1234	tRNA 3'-trailer cleavage
NRF13_RS05320	COG0095	Lipoate-protein ligase
NRF13_RS05325	COG0702	epimerase
NRF13_RS05330	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS05340	COG0501	Belongs to the peptidase M48B family
NRF13_RS05345	COG1404	Belongs to the peptidase S8 family
NRF13_RS05350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NRF13_RS05355	COG0406	alpha-ribazole phosphatase activity
NRF13_RS05360	COG0183	Belongs to the thiolase family
NRF13_RS05365	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS05370	COG1268	BioY protein
NRF13_RS05375	COG0840	transmembrane signaling receptor activity
NRF13_RS05380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRF13_RS05380	COG0723	plastoquinol--plastocyanin reductase activity
NRF13_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS05395	COG4903	ComK protein
NRF13_RS05405	COG5646	InterPro IPR014922
NRF13_RS05425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRF13_RS05440	COG0398	Pfam SNARE associated Golgi protein
NRF13_RS05445	COG0681	Belongs to the peptidase S26 family
NRF13_RS05450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRF13_RS05455	COG1846	Transcriptional regulator
NRF13_RS05460	COG3180	Ammonia monooxygenase
NRF13_RS05465	COG2814	Major facilitator Superfamily
NRF13_RS05475	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NRF13_RS05480	COG2323	membrane
NRF13_RS05495	COG0420	3'-5' exonuclease activity
NRF13_RS05500	COG0419	ATPase involved in DNA repair
NRF13_RS05505	COG1403	HNH endonuclease
NRF13_RS05545	COG0179	Fumarylacetoacetate (FAA) hydrolase
NRF13_RS05565	COG0367	asparagine synthase
NRF13_RS05570	COG1562	ergosterol biosynthetic process
NRF13_RS05575	COG0534	Mate efflux family protein
NRF13_RS05580	COG1917	Cupin 2, conserved barrel domain protein
NRF13_RS05580	COG2207	Transcriptional regulator
NRF13_RS05585	COG1609	Transcriptional regulator
NRF13_RS05590	COG0673	inositol 2-dehydrogenase activity
NRF13_RS05595	COG2318	DinB family
NRF13_RS05600	COG1279	arginine transmembrane transporter activity
NRF13_RS05605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS05610	COG1357	PFAM Pentapeptide repeats (8 copies)
NRF13_RS05615	COG2153	protein acetylation
NRF13_RS05620	COG0646	methionine synthase
NRF13_RS05620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NRF13_RS05630	COG2996	Protein conserved in bacteria
NRF13_RS05635	COG1744	ABC transporter substrate-binding protein PnrA-like
NRF13_RS05640	COG0840	transmembrane signaling receptor activity
NRF13_RS05650	COG1307	EDD domain protein, DegV family
NRF13_RS05655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS05675	COG0561	phosphatase activity
NRF13_RS05680	COG1073	alpha beta
NRF13_RS05685	COG2151	metal-sulfur cluster biosynthetic enzyme
NRF13_RS05695	COG0277	FAD linked oxidase domain protein
NRF13_RS05700	COG2271	Major facilitator Superfamily
NRF13_RS05710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NRF13_RS05720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRF13_RS05725	COG0505	Belongs to the CarA family
NRF13_RS05730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRF13_RS05735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRF13_RS05750	COG2267	carboxylic ester hydrolase activity
NRF13_RS05760	COG1744	ABC transporter substrate-binding protein PnrA-like
NRF13_RS05775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRF13_RS05780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRF13_RS05785	COG5504	Zn-dependent protease
NRF13_RS05790	COG0444	Belongs to the ABC transporter superfamily
NRF13_RS05795	COG4608	Belongs to the ABC transporter superfamily
NRF13_RS05805	COG0601	transmembrane transport
NRF13_RS05810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRF13_RS05830	COG0180	Tryptophanyl-tRNA synthetase
NRF13_RS05835	COG4166	transmembrane transport
NRF13_RS05840	COG0601	transmembrane transport
NRF13_RS05845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRF13_RS05850	COG0444	Belongs to the ABC transporter superfamily
NRF13_RS05855	COG4608	Belongs to the ABC transporter superfamily
NRF13_RS05865	COG0456	acetyltransferase
NRF13_RS05870	COG1393	Belongs to the ArsC family
NRF13_RS05875	COG0861	Integral membrane protein TerC family
NRF13_RS05880	COG4862	establishment of competence for transformation
NRF13_RS05885	COG4469	Competence protein
NRF13_RS05890	COG1164	Oligoendopeptidase f
NRF13_RS05900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NRF13_RS05905	COG2346	COG2346, Truncated hemoglobins
NRF13_RS05910	COG0741	lytic transglycosylase activity
NRF13_RS05915	COG4116	CYTH
NRF13_RS05925	COG2357	RelA SpoT domain protein
NRF13_RS05930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRF13_RS05935	COG0564	pseudouridine synthase activity
NRF13_RS05945	COG0569	domain protein
NRF13_RS05945	COG0475	glutathione-regulated potassium exporter activity
NRF13_RS05950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NRF13_RS05955	COG0352	thiamine-phosphate diphosphorylase activity
NRF13_RS05960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRF13_RS05965	COG2104	thiamine diphosphate biosynthetic process
NRF13_RS05975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRF13_RS05980	COG0351	phosphomethylpyrimidine kinase
NRF13_RS05985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NRF13_RS06040	COG0210	DNA helicase
NRF13_RS06060	COG1131	(ABC) transporter
NRF13_RS06070	COG2153	protein acetylation
NRF13_RS06080	COG2382	esterase
NRF13_RS06085	COG0626	cystathionine gamma-synthase activity
NRF13_RS06090	COG0626	cystathionine gamma-synthase activity
NRF13_RS06150	COG1484	DNA-dependent DNA replication
NRF13_RS06175	COG3655	Transcriptional regulator
NRF13_RS06220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRF13_RS06220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRF13_RS06240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRF13_RS06275	COG1780	Probably involved in ribonucleotide reductase function
NRF13_RS06280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRF13_RS06285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRF13_RS06305	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NRF13_RS06310	COG3584	3D domain protein
NRF13_RS06310	COG1388	LysM domain
NRF13_RS06365	COG1793	dna ligase
NRF13_RS06420	COG0582	viral genome integration into host DNA
NRF13_RS06500	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRF13_RS06510	COG5434	Belongs to the glycosyl hydrolase 28 family
NRF13_RS06535	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS06535	COG5632	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS06535	COG1388	LysM domain
NRF13_RS06610	COG0346	lactoylglutathione lyase activity
NRF13_RS06615	COG2367	Beta-lactamase
NRF13_RS06620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NRF13_RS06630	COG1846	Transcriptional regulator
NRF13_RS06640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NRF13_RS06645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRF13_RS06650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRF13_RS06655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS06655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS06660	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRF13_RS06670	COG1349	DNA-binding transcription factor activity
NRF13_RS06690	COG1285	pathogenesis
NRF13_RS06700	COG2205	protein histidine kinase activity
NRF13_RS06710	COG3383	formate dehydrogenase (NAD+) activity
NRF13_RS06715	COG2427	Protein of unknown function (DUF1641)
NRF13_RS06720	COG2124	cytochrome p450
NRF13_RS06725	COG1819	glycosyl
NRF13_RS06735	COG1587	Uroporphyrinogen-III synthase
NRF13_RS06740	COG0390	transport system, permease component
NRF13_RS06745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRF13_RS06750	COG0697	spore germination
NRF13_RS06755	COG4297	protein containing double-stranded beta helix domain
NRF13_RS06765	COG1252	NADH dehydrogenase
NRF13_RS06775	COG2211	Major facilitator Superfamily
NRF13_RS06780	COG1609	Transcriptional regulator
NRF13_RS06785	COG0246	Mannitol dehydrogenase
NRF13_RS06790	COG2721	sulfolactate sulfo-lyase activity
NRF13_RS06795	COG0745	RESPONSE REGULATOR receiver
NRF13_RS06800	COG2770	Histidine kinase
NRF13_RS06800	COG2205	protein histidine kinase activity
NRF13_RS06805	COG1121	(ABC) transporter
NRF13_RS06815	COG0730	response to heat
NRF13_RS06820	COG2318	DinB family
NRF13_RS06825	COG0457	Tetratricopeptide repeat
NRF13_RS06835	COG1388	LysM domain
NRF13_RS06835	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS06835	COG5632	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS06845	COG4195	phage-related replication protein
NRF13_RS06855	COG2856	Zn peptidase
NRF13_RS06860	COG1396	sequence-specific DNA binding
NRF13_RS06870	COG1522	sequence-specific DNA binding
NRF13_RS06875	COG1484	DNA-dependent DNA replication
NRF13_RS06895	COG1595	DNA-templated transcription, initiation
NRF13_RS06900	COG5484	DNA packaging
NRF13_RS06900	COG3728	DNA packaging
NRF13_RS06905	COG1783	phage Terminase large subunit
NRF13_RS06910	COG5518	Phage portal protein
NRF13_RS06915	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NRF13_RS06920	COG4653	Phage capsid family
NRF13_RS06970	COG5412	phage tail tape measure protein
NRF13_RS06970	COG3953	SLT domain
NRF13_RS06970	COG3953	SLT domain
NRF13_RS06970	COG3953	SLT domain
NRF13_RS06970	COG5412	phage tail tape measure protein
NRF13_RS06970	COG5412	phage tail tape measure protein
NRF13_RS06975	COG1652	LysM domain
NRF13_RS06980	COG4193	domain, Protein
NRF13_RS06990	COG3628	GPW Gp25 family protein
NRF13_RS06995	COG3299	homolog of phage Mu protein gp47
NRF13_RS07000	COG3778	Protein conserved in bacteria
NRF13_RS07040	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS07040	COG5632	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS07060	COG0306	phosphate transporter
NRF13_RS07065	COG1392	Phosphate transport regulator
NRF13_RS07070	COG0531	amino acid
NRF13_RS07075	COG0346	lactoylglutathione lyase activity
NRF13_RS07080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NRF13_RS07085	COG0463	Glycosyl transferase, family 2
NRF13_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRF13_RS07100	COG0477	Major facilitator Superfamily
NRF13_RS07105	COG2362	D-Aminopeptidase
NRF13_RS07110	COG0601	transmembrane transport
NRF13_RS07115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRF13_RS07120	COG0444	Belongs to the ABC transporter superfamily
NRF13_RS07125	COG4166	transmembrane transport
NRF13_RS07130	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRF13_RS07135	COG4948	Mandelate Racemase Muconate Lactonizing
NRF13_RS07140	COG0791	NLP P60 protein
NRF13_RS07145	COG4608	Belongs to the ABC transporter superfamily
NRF13_RS07150	COG2706	6-phosphogluconolactonase activity
NRF13_RS07155	COG1834	amidinotransferase
NRF13_RS07160	COG1607	acyl-coa hydrolase
NRF13_RS07165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRF13_RS07170	COG2076	Multidrug Resistance protein
NRF13_RS07175	COG2076	Multidrug Resistance protein
NRF13_RS07180	COG0788	formyltetrahydrofolate deformylase activity
NRF13_RS07185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NRF13_RS07195	COG1764	response to oxidative stress
NRF13_RS07200	COG1846	Transcriptional regulator
NRF13_RS07205	COG1764	response to oxidative stress
NRF13_RS07220	COG0463	Glycosyl transferase, family 2
NRF13_RS07220	COG0457	Tetratricopeptide repeat
NRF13_RS07230	COG2814	Major facilitator Superfamily
NRF13_RS07235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRF13_RS07245	COG1404	Belongs to the peptidase S8 family
NRF13_RS07250	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS07255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NRF13_RS07260	COG1122	ATPase activity
NRF13_RS07265	COG4721	ABC-type cobalt transport system, permease component
NRF13_RS07270	COG1388	LysM domain
NRF13_RS07270	COG3858	chitin binding
NRF13_RS07280	COG2239	Acts as a magnesium transporter
NRF13_RS07285	COG0789	Transcriptional regulator
NRF13_RS07300	COG1846	Transcriptional regulator
NRF13_RS07305	COG0726	polysaccharide deacetylase
NRF13_RS07310	COG1793	dna ligase
NRF13_RS07310	COG3285	dna ligase
NRF13_RS07315	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NRF13_RS07320	COG0586	Pfam SNARE associated Golgi protein
NRF13_RS07330	COG1191	sigma factor activity
NRF13_RS07355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NRF13_RS07360	COG2323	membrane
NRF13_RS07370	COG3594	Acyltransferase
NRF13_RS07375	COG5002	protein histidine kinase activity
NRF13_RS07380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRF13_RS07400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRF13_RS07405	COG0436	Aminotransferase
NRF13_RS07435	COG3852	Histidine kinase
NRF13_RS07440	COG1846	Transcriptional regulator
NRF13_RS07445	COG1360	Flagellar Motor Protein
NRF13_RS07450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRF13_RS07455	COG0542	response to heat
NRF13_RS07460	COG3949	Membrane
NRF13_RS07475	COG0720	synthase
NRF13_RS07480	COG0602	queuosine metabolic process
NRF13_RS07495	COG4873	Protein conserved in bacteria
NRF13_RS07505	COG3773	Cell wall hydrolase
NRF13_RS07510	COG2244	polysaccharide biosynthetic process
NRF13_RS07515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS07520	COG2217	Heavy metal translocating P-type atpase
NRF13_RS07525	COG0006	proline dipeptidase activity
NRF13_RS07535	COG1609	Transcriptional regulator
NRF13_RS07540	COG3711	transcriptional antiterminator
NRF13_RS07545	COG1263	PTS System
NRF13_RS07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS07545	COG2190	(PTS) system
NRF13_RS07550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS07555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRF13_RS07565	COG1533	DNA photolyase activity
NRF13_RS07570	COG0840	transmembrane signaling receptor activity
NRF13_RS07575	COG2084	Dehydrogenase
NRF13_RS07580	COG2340	Cysteine-rich secretory protein family
NRF13_RS07585	COG0768	penicillin binding
NRF13_RS07590	COG4191	Histidine kinase
NRF13_RS07595	COG0436	Aminotransferase
NRF13_RS07605	COG0835	chemotaxis
NRF13_RS07605	COG0784	Response regulator, receiver
NRF13_RS07615	COG2814	Major facilitator Superfamily
NRF13_RS07620	COG1376	ErfK ybiS ycfS ynhG family protein
NRF13_RS07625	COG1408	metallophosphoesterase
NRF13_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS07640	COG2200	EAL domain
NRF13_RS07645	COG4703	Protein of unknown function (DUF1797)
NRF13_RS07650	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NRF13_RS07660	COG0517	IMP dehydrogenase activity
NRF13_RS07665	COG0583	DNA-binding transcription factor activity
NRF13_RS07670	COG0716	FMN binding
NRF13_RS07680	COG0716	FMN binding
NRF13_RS07700	COG0668	transmembrane transport
NRF13_RS07705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS07725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRF13_RS07730	COG0303	'Molybdopterin
NRF13_RS07735	COG1763	Mo-molybdopterin cofactor biosynthetic process
NRF13_RS07740	COG0314	molybdopterin synthase activity
NRF13_RS07745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NRF13_RS07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NRF13_RS07760	COG1136	(ABC) transporter
NRF13_RS07765	COG0577	efflux transmembrane transporter activity
NRF13_RS07770	COG1349	DNA-binding transcription factor activity
NRF13_RS07775	COG1105	Belongs to the carbohydrate kinase PfkB family
NRF13_RS07780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRF13_RS07780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS07780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRF13_RS07785	COG0681	Belongs to the peptidase S26 family
NRF13_RS07795	COG0488	(ABC) transporter
NRF13_RS07800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRF13_RS07805	COG2309	aminopeptidase activity
NRF13_RS07815	COG1077	Cell shape determining protein MreB Mrl
NRF13_RS07820	COG2002	toxin-antitoxin pair type II binding
NRF13_RS07825	COG3852	Histidine kinase
NRF13_RS07830	COG2105	PFAM AIG2 family protein
NRF13_RS07830	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NRF13_RS07835	COG0569	domain protein
NRF13_RS07845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NRF13_RS07855	COG0561	phosphatase activity
NRF13_RS07860	COG0242	peptide deformylase activity
NRF13_RS07870	COG0497	DNA recombination
NRF13_RS07880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS07880	COG3321	synthase
NRF13_RS07880	COG4221	oxidoreductase activity
NRF13_RS07885	COG4221	oxidoreductase activity
NRF13_RS07885	COG3321	synthase
NRF13_RS07885	COG0300	oxidoreductase activity
NRF13_RS07885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS07890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS07890	COG3321	synthase
NRF13_RS07890	COG4221	oxidoreductase activity
NRF13_RS07895	COG0300	oxidoreductase activity
NRF13_RS07895	COG3321	synthase
NRF13_RS07895	COG4221	oxidoreductase activity
NRF13_RS07895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS07900	COG4221	oxidoreductase activity
NRF13_RS07900	COG0300	oxidoreductase activity
NRF13_RS07900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS07900	COG3321	synthase
NRF13_RS07905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS07905	COG3321	synthase
NRF13_RS07905	COG4221	oxidoreductase activity
NRF13_RS07905	COG0300	oxidoreductase activity
NRF13_RS07910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS07910	COG3321	synthase
NRF13_RS07910	COG4221	oxidoreductase activity
NRF13_RS07915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRF13_RS07920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NRF13_RS07925	COG0022	dehydrogenase e1 component
NRF13_RS07930	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRF13_RS07935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRF13_RS07940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS07955	COG1982	Orn Lys Arg decarboxylase major
NRF13_RS07975	COG0483	inositol monophosphate 1-phosphatase activity
NRF13_RS07985	COG3227	Zinc metalloprotease (Elastase)
NRF13_RS07990	COG1595	DNA-templated transcription, initiation
NRF13_RS08010	COG1217	gtp-binding protein TYPA
NRF13_RS08020	COG4896	Protein conserved in bacteria
NRF13_RS08030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRF13_RS08035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NRF13_RS08040	COG2066	Belongs to the glutaminase family
NRF13_RS08050	COG0772	Belongs to the SEDS family
NRF13_RS08055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NRF13_RS08070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRF13_RS08070	COG2010	Cytochrome c
NRF13_RS08075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRF13_RS08080	COG1845	cytochrome c oxidase, subunit III
NRF13_RS08085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NRF13_RS08090	COG3336	cytochrome c oxidase
NRF13_RS08100	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NRF13_RS08105	COG2340	Cysteine-rich secretory protein family
NRF13_RS08120	COG3679	Belongs to the UPF0342 family
NRF13_RS08135	COG0742	ribosomal rna small subunit methyltransferase
NRF13_RS08145	COG3314	Sporulation integral membrane protein YlbJ
NRF13_RS08150	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRF13_RS08155	COG3480	Lon protease (S16) C-terminal proteolytic domain
NRF13_RS08165	COG1399	metal-binding, possibly nucleic acid-binding protein
NRF13_RS08185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRF13_RS08205	COG4839	cell division protein FtsL
NRF13_RS08210	COG0768	penicillin binding
NRF13_RS08215	COG0768	penicillin binding
NRF13_RS08235	COG0772	Belongs to the SEDS family
NRF13_RS08250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRF13_RS08255	COG0849	cell division
NRF13_RS08260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NRF13_RS08265	COG1404	Belongs to the peptidase S8 family
NRF13_RS08265	COG4412	M6 family metalloprotease domain protein
NRF13_RS08275	COG1191	sigma factor activity
NRF13_RS08280	COG1191	sigma factor activity
NRF13_RS08285	COG1119	ATPase activity
NRF13_RS08290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRF13_RS08295	COG1873	PFAM PRC-barrel domain
NRF13_RS08300	COG1496	oxidoreductase activity
NRF13_RS08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRF13_RS08315	COG0762	integral membrane protein
NRF13_RS08320	COG2302	S4 RNA-binding domain
NRF13_RS08325	COG3599	regulation of cell shape
NRF13_RS08330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRF13_RS08335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRF13_RS08345	COG0564	pseudouridine synthase activity
NRF13_RS08355	COG2233	PERMEase
NRF13_RS08365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRF13_RS08370	COG0505	Belongs to the CarA family
NRF13_RS08375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRF13_RS08390	COG0284	orotidine-5'-phosphate decarboxylase activity
NRF13_RS08395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRF13_RS08405	COG0306	phosphate transporter
NRF13_RS08420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRF13_RS08425	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NRF13_RS08430	COG1648	precorrin-2 dehydrogenase activity
NRF13_RS08440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NRF13_RS08445	COG1561	YicC-like family, N-terminal region
NRF13_RS08455	COG0194	GDP metabolic process
NRF13_RS08465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRF13_RS08470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NRF13_RS08475	COG0242	peptide deformylase activity
NRF13_RS08485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NRF13_RS08485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRF13_RS08495	COG0631	protein serine/threonine phosphatase activity
NRF13_RS08500	COG2815	serine threonine protein kinase
NRF13_RS08500	COG0515	serine threonine protein kinase
NRF13_RS08510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRF13_RS08515	COG1564	THIamine pyrophosphokinase
NRF13_RS08530	COG1302	Protein conserved in bacteria
NRF13_RS08535	COG1461	Dihydroxyacetone kinase
NRF13_RS08540	COG1760	l-serine dehydratase
NRF13_RS08545	COG1760	l-serine dehydratase
NRF13_RS08550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRF13_RS08565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NRF13_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS08585	COG1196	nuclear chromosome segregation
NRF13_RS08590	COG0552	protein localization to endoplasmic reticulum
NRF13_RS08605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NRF13_RS08615	COG1837	Belongs to the UPF0109 family
NRF13_RS08640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRF13_RS08655	COG2257	FlhB HrpN YscU SpaS Family
NRF13_RS08665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NRF13_RS08670	COG0758	DNA mediated transformation
NRF13_RS08675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRF13_RS08685	COG4974	Belongs to the 'phage' integrase family
NRF13_RS08705	COG1815	bacterial-type flagellum-dependent cell motility
NRF13_RS08710	COG1558	bacterial-type flagellum-dependent cell motility
NRF13_RS08715	COG1677	Flagellar hook-basal body complex protein FliE
NRF13_RS08720	COG1766	The M ring may be actively involved in energy transduction
NRF13_RS08725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRF13_RS08730	COG1317	bacterial-type flagellum organization
NRF13_RS08735	COG1157	protein secretion by the type III secretion system
NRF13_RS08740	COG2882	bacterial-type flagellum organization
NRF13_RS08745	COG3334	PFAM MgtE intracellular
NRF13_RS08750	COG3144	bacterial-type flagellum assembly
NRF13_RS08755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NRF13_RS08760	COG4786	Flagellar basal body rod
NRF13_RS08765	COG1582	Flagellar protein (FlbD)
NRF13_RS08770	COG1580	Controls the rotational direction of flagella during chemotaxis
NRF13_RS08775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRF13_RS08780	COG1776	CheC inhibitor of MCP methylation
NRF13_RS08780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NRF13_RS08785	COG2201	protein-glutamate methylesterase activity
NRF13_RS08790	COG3190	flagellar
NRF13_RS08795	COG1338	Plays a role in the flagellum-specific transport system
NRF13_RS08800	COG1987	bacterial-type flagellum assembly
NRF13_RS08805	COG1684	flagellar biosynthetic protein fliR
NRF13_RS08810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRF13_RS08815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NRF13_RS08820	COG1419	protein localization to endoplasmic reticulum
NRF13_RS08825	COG0455	bacterial-type flagellum organization
NRF13_RS08830	COG2201	protein-glutamate methylesterase activity
NRF13_RS08835	COG0643	Histidine kinase
NRF13_RS08835	COG2198	Histidine kinase
NRF13_RS08840	COG0835	chemotaxis
NRF13_RS08845	COG1776	CheC inhibitor of MCP methylation
NRF13_RS08855	COG1191	sigma factor activity
NRF13_RS08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRF13_RS08890	COG4589	Belongs to the CDS family
NRF13_RS08900	COG0750	zinc metalloprotease
NRF13_RS08920	COG0195	Participates in both transcription termination and antitermination
NRF13_RS08925	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NRF13_RS08930	COG1358	cellular component organization or biogenesis
NRF13_RS08940	COG1550	Protein conserved in bacteria
NRF13_RS08955	COG0196	riboflavin kinase activity
NRF13_RS08970	COG0726	polysaccharide deacetylase
NRF13_RS08975	COG0612	Peptidase, M16
NRF13_RS08980	COG1873	PFAM PRC-barrel domain
NRF13_RS08985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRF13_RS08990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NRF13_RS08995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NRF13_RS09000	COG0527	aspartate kinase activity
NRF13_RS09010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NRF13_RS09015	COG0740	serine-type endopeptidase activity
NRF13_RS09025	COG4980	gas vesicle protein
NRF13_RS09025	COG1674	ftsk spoiiie
NRF13_RS09030	COG2188	Transcriptional regulator
NRF13_RS09035	COG2814	Major facilitator Superfamily
NRF13_RS09040	COG1846	Transcriptional regulator
NRF13_RS09045	COG2409	Drug exporters of the RND superfamily
NRF13_RS09045	COG1033	growth of symbiont in host cell
NRF13_RS09050	COG0612	Peptidase, M16
NRF13_RS09055	COG0612	Peptidase, M16
NRF13_RS09060	COG0300	oxidoreductase activity
NRF13_RS09075	COG1426	Protein conserved in bacteria
NRF13_RS09080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRF13_RS09095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRF13_RS09105	COG1692	metallophosphoesterase
NRF13_RS09110	COG2359	stage V sporulation protein S
NRF13_RS09130	COG4550	Control of competence regulator ComK, YlbF/YmcA
NRF13_RS09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS09195	COG3425	synthase
NRF13_RS09200	COG1024	Enoyl-CoA hydratase
NRF13_RS09205	COG1024	Enoyl-CoA hydratase
NRF13_RS09210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09210	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS09210	COG0300	oxidoreductase activity
NRF13_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09210	COG3321	synthase
NRF13_RS09215	COG4221	oxidoreductase activity
NRF13_RS09215	COG3321	synthase
NRF13_RS09215	COG0300	oxidoreductase activity
NRF13_RS09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS09220	COG3321	synthase
NRF13_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS09220	COG3321	synthase
NRF13_RS09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09225	COG3321	synthase
NRF13_RS09225	COG4221	oxidoreductase activity
NRF13_RS09230	COG3321	synthase
NRF13_RS09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS09230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NRF13_RS09230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRF13_RS09235	COG2124	cytochrome p450
NRF13_RS09240	COG3209	COG3209 Rhs family protein
NRF13_RS09245	COG3619	membrane
NRF13_RS09255	COG1404	Belongs to the peptidase S8 family
NRF13_RS09265	COG4195	phage-related replication protein
NRF13_RS09270	COG1764	response to oxidative stress
NRF13_RS09280	COG2076	Multidrug Resistance protein
NRF13_RS09320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRF13_RS09325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRF13_RS09330	COG4112	unkown
NRF13_RS09335	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS09340	COG0464	growth
NRF13_RS09345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRF13_RS09350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NRF13_RS09355	COG0789	Transcriptional regulator
NRF13_RS09360	COG0174	glutamine synthetase
NRF13_RS09410	COG2211	Major facilitator Superfamily
NRF13_RS09415	COG3507	Belongs to the glycosyl hydrolase 43 family
NRF13_RS09435	COG1070	Carbohydrate kinase
NRF13_RS09440	COG0574	Belongs to the PEP-utilizing enzyme family
NRF13_RS09440	COG3848	Pyruvate phosphate dikinase
NRF13_RS09460	COG2378	regulation of single-species biofilm formation
NRF13_RS09465	COG2318	DinB family
NRF13_RS09470	COG1064	alcohol dehydrogenase
NRF13_RS09510	COG3397	chitin binding
NRF13_RS09520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRF13_RS09535	COG5434	Belongs to the glycosyl hydrolase 28 family
NRF13_RS09540	COG0756	dUTP diphosphatase activity
NRF13_RS09545	COG4195	phage-related replication protein
NRF13_RS09580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NRF13_RS09590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NRF13_RS09610	COG0785	Cytochrome C biogenesis protein
NRF13_RS09615	COG2201	protein-glutamate methylesterase activity
NRF13_RS09620	COG4846	Membrane protein involved in cytochrome C biogenesis
NRF13_RS09630	COG0071	Belongs to the small heat shock protein (HSP20) family
NRF13_RS09645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NRF13_RS09650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS09670	COG0824	Thioesterase
NRF13_RS09680	COG4841	protein insertion into membrane
NRF13_RS09690	COG1832	CoA-binding protein
NRF13_RS09695	COG0187	DNA topoisomerase II activity
NRF13_RS09700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NRF13_RS09715	COG1115	amino acid carrier protein
NRF13_RS09725	COG1063	alcohol dehydrogenase
NRF13_RS09730	COG0800	Aldolase
NRF13_RS09735	COG1312	Catalyzes the dehydration of D-mannonate
NRF13_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09745	COG1609	Transcriptional regulator
NRF13_RS09750	COG2271	Major facilitator Superfamily
NRF13_RS09785	COG2205	protein histidine kinase activity
NRF13_RS09790	COG0745	RESPONSE REGULATOR receiver
NRF13_RS09800	COG3507	Belongs to the glycosyl hydrolase 43 family
NRF13_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS09830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NRF13_RS09835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NRF13_RS09840	COG2610	gluconate transmembrane transporter activity
NRF13_RS09845	COG2124	cytochrome p450
NRF13_RS09865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRF13_RS09875	COG2246	polysaccharide biosynthetic process
NRF13_RS09880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRF13_RS09885	COG0586	Pfam SNARE associated Golgi protein
NRF13_RS09890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRF13_RS09895	COG1024	Enoyl-CoA hydratase
NRF13_RS09900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRF13_RS09905	COG0511	ligase activity, forming carbon-carbon bonds
NRF13_RS09910	COG0439	Biotin carboxylase
NRF13_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS09920	COG1960	acyl-CoA dehydrogenase activity
NRF13_RS09925	COG1649	PFAM Uncharacterised BCR, COG1649
NRF13_RS09935	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NRF13_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS09960	COG2027	D-alanyl-D-alanine carboxypeptidase
NRF13_RS09965	COG2017	converts alpha-aldose to the beta-anomer
NRF13_RS09970	COG0534	Mate efflux family protein
NRF13_RS09985	COG0582	viral genome integration into host DNA
NRF13_RS09990	COG0166	Belongs to the GPI family
NRF13_RS09995	COG0405	Gamma-glutamyltransferase
NRF13_RS10000	COG2814	Major facilitator Superfamily
NRF13_RS10005	COG0640	Transcriptional regulator
NRF13_RS10020	COG0604	alcohol dehydrogenase
NRF13_RS10025	COG0493	'glutamate synthase
NRF13_RS10030	COG0067	glutamate synthase
NRF13_RS10030	COG0069	glutamate synthase activity
NRF13_RS10030	COG0070	glutamate synthase
NRF13_RS10035	COG0583	DNA-binding transcription factor activity
NRF13_RS10040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NRF13_RS10055	COG0300	oxidoreductase activity
NRF13_RS10060	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NRF13_RS10070	COG2814	Major facilitator Superfamily
NRF13_RS10075	COG1070	Carbohydrate kinase
NRF13_RS10080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRF13_RS10085	COG0243	molybdopterin cofactor binding
NRF13_RS10165	COG3220	belongs to the UPF0276 family
NRF13_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS10195	COG1733	regulation of RNA biosynthetic process
NRF13_RS10200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRF13_RS10205	COG0662	Cupin 2, conserved barrel domain protein
NRF13_RS10205	COG2207	Transcriptional regulator
NRF13_RS10210	COG1309	transcriptional regulator
NRF13_RS10215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS10225	COG0640	Transcriptional regulator
NRF13_RS10230	COG0741	lytic transglycosylase activity
NRF13_RS10235	COG2322	membrane
NRF13_RS10250	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRF13_RS10260	COG3584	3D domain protein
NRF13_RS10260	COG1388	LysM domain
NRF13_RS10265	COG0514	ATP-dependent DNA helicase (RecQ)
NRF13_RS10275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NRF13_RS10280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRF13_RS10295	COG0071	Belongs to the small heat shock protein (HSP20) family
NRF13_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS10330	COG1657	PFAM Prenyltransferase squalene oxidase
NRF13_RS10335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRF13_RS10340	COG0733	neurotransmitter:sodium symporter activity
NRF13_RS10345	COG0385	Bile acid
NRF13_RS10350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS10355	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRF13_RS10365	COG4548	von Willebrand factor, type A
NRF13_RS10370	COG0714	Associated with various cellular activities
NRF13_RS10375	COG2032	superoxide dismutase activity
NRF13_RS10380	COG0791	NLP P60 protein
NRF13_RS10380	COG1388	LysM domain
NRF13_RS10385	COG1819	glycosyl
NRF13_RS10390	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NRF13_RS10395	COG0534	Mate efflux family protein
NRF13_RS10400	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS10405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRF13_RS10410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRF13_RS10420	COG2962	Rard protein
NRF13_RS10435	COG1942	4-Oxalocrotonate Tautomerase
NRF13_RS10445	COG1733	regulation of RNA biosynthetic process
NRF13_RS10450	COG0778	Nitroreductase
NRF13_RS10455	COG0400	carboxylic ester hydrolase activity
NRF13_RS10460	COG0346	lactoylglutathione lyase activity
NRF13_RS10470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRF13_RS10480	COG2723	6-phospho-beta-galactosidase activity
NRF13_RS10485	COG2188	Transcriptional regulator
NRF13_RS10490	COG0793	Belongs to the peptidase S41A family
NRF13_RS10490	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS10495	COG2226	methyltransferase
NRF13_RS10505	COG1876	peptidase activity
NRF13_RS10525	COG0671	phosphoesterase, PA-phosphatase related
NRF13_RS10560	COG1509	lysine 2,3-aminomutase activity
NRF13_RS10565	COG0456	acetyltransferase
NRF13_RS10570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRF13_RS10575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NRF13_RS10580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NRF13_RS10585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRF13_RS10590	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NRF13_RS10600	COG0456	acetyltransferase
NRF13_RS10605	COG0463	Glycosyl transferase, family 2
NRF13_RS10620	COG4641	Protein conserved in bacteria
NRF13_RS10630	COG1086	Polysaccharide biosynthesis protein
NRF13_RS10685	COG1388	LysM domain
NRF13_RS10690	COG0457	Tetratricopeptide repeat
NRF13_RS10700	COG3391	amine dehydrogenase activity
NRF13_RS10745	COG5444	nuclease activity
NRF13_RS10785	COG1846	Transcriptional regulator
NRF13_RS10790	COG4698	Protein conserved in bacteria
NRF13_RS10795	COG2755	lipolytic protein G-D-S-L family
NRF13_RS10800	COG1999	signal sequence binding
NRF13_RS10810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRF13_RS10815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NRF13_RS10820	COG1272	protein, Hemolysin III
NRF13_RS10825	COG0204	Acyl-transferase
NRF13_RS10830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRF13_RS10845	COG2136	Putative SAM-dependent methyltransferase
NRF13_RS10845	COG2521	methyltransferase
NRF13_RS10860	COG1413	lyase activity
NRF13_RS10865	COG1418	mRNA catabolic process
NRF13_RS10870	COG0386	Belongs to the glutathione peroxidase family
NRF13_RS10880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRF13_RS10890	COG1278	Cold shock
NRF13_RS10910	COG0328	RNA-DNA hybrid ribonuclease activity
NRF13_RS10915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NRF13_RS10920	COG0328	RNA-DNA hybrid ribonuclease activity
NRF13_RS10930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRF13_RS10945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NRF13_RS10955	COG1755	Isoprenylcysteine carboxyl methyltransferase
NRF13_RS10960	COG3424	synthase
NRF13_RS10985	COG1335	isochorismatase
NRF13_RS10995	COG2233	PERMEase
NRF13_RS11005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NRF13_RS11010	COG1199	ATP-dependent helicase activity
NRF13_RS11025	COG0116	Belongs to the methyltransferase superfamily
NRF13_RS11055	COG3359	exonuclease
NRF13_RS11060	COG1111	helicase
NRF13_RS11060	COG1205	dead DEAH box helicase
NRF13_RS11065	COG2190	(PTS) system
NRF13_RS11070	COG0071	Belongs to the small heat shock protein (HSP20) family
NRF13_RS11110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRF13_RS11110	COG4499	WXG100 protein secretion system (Wss), protein YukC
NRF13_RS11120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NRF13_RS11125	COG3935	DnaD domain protein
NRF13_RS11135	COG0436	Aminotransferase
NRF13_RS11140	COG5353	protein conserved in bacteria
NRF13_RS11150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRF13_RS11150	COG1199	ATP-dependent helicase activity
NRF13_RS11180	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS11185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRF13_RS11200	COG1694	Mazg nucleotide pyrophosphohydrolase
NRF13_RS11205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS11210	COG2140	Oxalate decarboxylase
NRF13_RS11220	COG4347	Protein of unknown function (DUF1405)
NRF13_RS11225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRF13_RS11225	COG2010	Cytochrome c
NRF13_RS11230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRF13_RS11235	COG0723	plastoquinol--plastocyanin reductase activity
NRF13_RS11250	COG0457	Tetratricopeptide repeat
NRF13_RS11260	COG0287	Prephenate dehydrogenase
NRF13_RS11295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRF13_RS11300	COG4401	Chorismate mutase type I
NRF13_RS11315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NRF13_RS11320	COG0105	UTP biosynthetic process
NRF13_RS11325	COG0142	geranyltranstransferase activity
NRF13_RS11335	COG0142	geranyltranstransferase activity
NRF13_RS11350	COG0776	regulation of translation
NRF13_RS11355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NRF13_RS11395	COG0539	negative regulation of cytoplasmic translation
NRF13_RS11410	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NRF13_RS11415	COG2959	enzyme of heme biosynthesis
NRF13_RS11420	COG3773	Cell wall hydrolase
NRF13_RS11420	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS11425	COG2339	peptidase activity
NRF13_RS11430	COG0492	ferredoxin-NADP+ reductase activity
NRF13_RS11435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NRF13_RS11440	COG4862	establishment of competence for transformation
NRF13_RS11445	COG1408	metallophosphoesterase
NRF13_RS11455	COG1388	LysM domain
NRF13_RS11460	COG1266	CAAX protease self-immunity
NRF13_RS11465	COG0514	ATP-dependent DNA helicase (RecQ)
NRF13_RS11470	COG4955	Helix-turn-helix domain
NRF13_RS11475	COG1141	Ferredoxin
NRF13_RS11480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NRF13_RS11485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRF13_RS11495	COG1595	DNA-templated transcription, initiation
NRF13_RS11500	COG5002	protein histidine kinase activity
NRF13_RS11505	COG0745	RESPONSE REGULATOR receiver
NRF13_RS11510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRF13_RS11515	COG1333	cytochrome c biogenesis protein
NRF13_RS11520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS11525	COG1187	pseudouridine synthase activity
NRF13_RS11530	COG0700	Nucleoside recognition
NRF13_RS11535	COG2715	membrane protein required for spore maturation
NRF13_RS11540	COG1686	Belongs to the peptidase S11 family
NRF13_RS11565	COG1547	Domain of unknown function (DUF309)
NRF13_RS11570	COG0456	acetyltransferase
NRF13_RS11585	COG0307	riboflavin synthase, alpha
NRF13_RS11590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRF13_RS11590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NRF13_RS11600	COG0681	Belongs to the peptidase S26 family
NRF13_RS11610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRF13_RS11615	COG4086	secreted protein
NRF13_RS11620	COG0019	diaminopimelate decarboxylase activity
NRF13_RS11625	COG0697	spore germination
NRF13_RS11640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRF13_RS11660	COG1191	sigma factor activity
NRF13_RS11670	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS11675	COG1686	Belongs to the peptidase S11 family
NRF13_RS11680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NRF13_RS11685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NRF13_RS11690	COG4974	Belongs to the 'phage' integrase family
NRF13_RS11700	COG0735	belongs to the Fur family
NRF13_RS11705	COG1300	Membrane
NRF13_RS11720	COG0281	malic enzyme
NRF13_RS11725	COG1757	Na H antiporter
NRF13_RS11730	COG1027	Aspartate ammonia-lyase
NRF13_RS11735	COG0252	asparaginase activity
NRF13_RS11740	COG1396	sequence-specific DNA binding
NRF13_RS11745	COG1379	DNA repair
NRF13_RS11750	COG0494	nUDIX hydrolase
NRF13_RS11760	COG0667	Aldo Keto reductase
NRF13_RS11770	COG1073	alpha beta
NRF13_RS11780	COG4918	Iron-sulphur cluster biosynthesis
NRF13_RS11785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NRF13_RS11785	COG0456	acetyltransferase
NRF13_RS11790	COG2329	Antibiotic biosynthesis monooxygenase
NRF13_RS11795	COG0456	acetyltransferase
NRF13_RS11800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRF13_RS11815	COG0628	permease
NRF13_RS11825	COG0346	lactoylglutathione lyase activity
NRF13_RS11835	COG3048	D-serine ammonia-lyase activity
NRF13_RS11840	COG0300	oxidoreductase activity
NRF13_RS11845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS11850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRF13_RS11855	COG1024	Enoyl-CoA hydratase
NRF13_RS11860	COG3425	synthase
NRF13_RS11865	COG2124	cytochrome p450
NRF13_RS11870	COG3321	synthase
NRF13_RS11870	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS11870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS11875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS11875	COG3321	synthase
NRF13_RS11875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11880	COG3321	synthase
NRF13_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11880	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS11880	COG0300	oxidoreductase activity
NRF13_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS11885	COG0300	oxidoreductase activity
NRF13_RS11885	COG3321	synthase
NRF13_RS11885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS11890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS11890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11890	COG3321	synthase
NRF13_RS11895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11895	COG0300	oxidoreductase activity
NRF13_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11895	COG3321	synthase
NRF13_RS11895	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS11900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRF13_RS11900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS11900	COG3321	synthase
NRF13_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS11910	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS11925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NRF13_RS11925	COG2070	2-Nitropropane dioxygenase
NRF13_RS11930	COG0250	Participates in transcription elongation, termination and antitermination
NRF13_RS11950	COG0596	Alpha beta hydrolase
NRF13_RS11965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NRF13_RS11970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NRF13_RS11985	COG0706	membrane insertase activity
NRF13_RS11990	COG2195	Cleaves the N-terminal amino acid of tripeptides
NRF13_RS11995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRF13_RS12000	COG0346	lactoylglutathione lyase activity
NRF13_RS12010	COG1376	ErfK ybiS ycfS ynhG family protein
NRF13_RS12015	COG4129	membrane
NRF13_RS12020	COG1126	abc transporter atp-binding protein
NRF13_RS12025	COG0765	amino acid transport
NRF13_RS12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS12040	COG1597	lipid kinase activity
NRF13_RS12045	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRF13_RS12050	COG0022	dehydrogenase e1 component
NRF13_RS12055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NRF13_RS12060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRF13_RS12065	COG3426	butyrate kinase activity
NRF13_RS12070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NRF13_RS12075	COG0280	phosphate acetyltransferase
NRF13_RS12080	COG3829	transcription factor binding
NRF13_RS12080	COG3290	protein histidine kinase activity
NRF13_RS12090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRF13_RS12095	COG2079	MmgE PrpD family protein
NRF13_RS12100	COG0372	Belongs to the citrate synthase family
NRF13_RS12105	COG1960	acyl-CoA dehydrogenase activity
NRF13_RS12110	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRF13_RS12115	COG0183	Belongs to the thiolase family
NRF13_RS12120	COG0584	glycerophosphoryl diester phosphodiesterase
NRF13_RS12125	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS12150	COG1902	pentaerythritol trinitrate reductase activity
NRF13_RS12165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRF13_RS12170	COG0745	RESPONSE REGULATOR receiver
NRF13_RS12175	COG0750	zinc metalloprotease
NRF13_RS12180	COG0497	DNA recombination
NRF13_RS12190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NRF13_RS12200	COG0142	geranyltranstransferase activity
NRF13_RS12210	COG1570	exodeoxyribonuclease VII activity
NRF13_RS12225	COG1302	Protein conserved in bacteria
NRF13_RS12230	COG0439	Biotin carboxylase
NRF13_RS12235	COG0511	ligase activity, forming carbon-carbon bonds
NRF13_RS12275	COG3854	ATPases associated with a variety of cellular activities
NRF13_RS12290	COG0006	proline dipeptidase activity
NRF13_RS12300	COG3872	metal-dependent enzyme
NRF13_RS12310	COG1752	Esterase of the alpha-beta hydrolase superfamily
NRF13_RS12325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRF13_RS12345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRF13_RS12360	COG1396	sequence-specific DNA binding
NRF13_RS12370	COG0681	Belongs to the peptidase S26 family
NRF13_RS12395	COG4940	Competence protein ComGF
NRF13_RS12405	COG4970	Tfp pilus assembly protein FimT
NRF13_RS12410	COG4537	Required for transformation and DNA binding
NRF13_RS12415	COG1459	type II secretion system
NRF13_RS12420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NRF13_RS12425	COG0598	Magnesium transport protein CorA
NRF13_RS12430	COG1253	flavin adenine dinucleotide binding
NRF13_RS12435	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS12445	COG1393	Belongs to the ArsC family
NRF13_RS12455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS12465	COG0011	TIGRFAM Protein of
NRF13_RS12475	COG2866	Carboxypeptidase
NRF13_RS12480	COG1940	carbohydrate kinase activity
NRF13_RS12485	COG4483	Protein conserved in bacteria
NRF13_RS12490	COG1757	Na H antiporter
NRF13_RS12500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRF13_RS12515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRF13_RS12520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRF13_RS12525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NRF13_RS12530	COG0581	inorganic phosphate transmembrane transporter activity
NRF13_RS12535	COG0573	inorganic phosphate transmembrane transporter activity
NRF13_RS12540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NRF13_RS12545	COG0768	penicillin binding
NRF13_RS12550	COG0477	Major facilitator Superfamily
NRF13_RS12555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRF13_RS12560	COG2839	Protein conserved in bacteria
NRF13_RS12565	COG5521	maltodextrose utilization protein MalA
NRF13_RS12570	COG1388	LysM domain
NRF13_RS12580	COG4709	membrane
NRF13_RS12585	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NRF13_RS12590	COG0735	belongs to the Fur family
NRF13_RS12595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS12610	COG0513	Belongs to the DEAD box helicase family
NRF13_RS12625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRF13_RS12630	COG2384	SAM-dependent methyltransferase
NRF13_RS12635	COG2010	Cytochrome c
NRF13_RS12640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRF13_RS12645	COG0358	DNA primase activity
NRF13_RS12660	COG0517	IMP dehydrogenase activity
NRF13_RS12665	COG0751	glycine-tRNA ligase activity
NRF13_RS12685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NRF13_RS12690	COG0295	cytidine deaminase activity
NRF13_RS12695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NRF13_RS12705	COG1480	7TM receptor with intracellular HD hydrolase
NRF13_RS12710	COG1702	phosphate starvation-inducible protein PhoH
NRF13_RS12715	COG0561	phosphatase activity
NRF13_RS12730	COG4864	UPF0365 protein
NRF13_RS12735	COG1030	water channel activity
NRF13_RS12740	COG1610	YqeY-like protein
NRF13_RS12750	COG1283	sodium-dependent phosphate transmembrane transporter activity
NRF13_RS12755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRF13_RS12760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NRF13_RS12790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NRF13_RS12805	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS12835	COG2333	competence protein COMEC
NRF13_RS12835	COG0658	competence protein
NRF13_RS12840	COG2131	deaminase
NRF13_RS12845	COG1596	polysaccharide export
NRF13_RS12845	COG1555	photosystem II stabilization
NRF13_RS12850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRF13_RS12855	COG2226	methyltransferase
NRF13_RS12860	COG0799	negative regulation of ribosome biogenesis
NRF13_RS12865	COG1713	HD superfamily hydrolase involved in NAD metabolism
NRF13_RS12875	COG1534	Rna-binding protein
NRF13_RS12880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRF13_RS12885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NRF13_RS12890	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NRF13_RS12905	COG2755	lipolytic protein G-D-S-L family
NRF13_RS12915	COG0398	Pfam SNARE associated Golgi protein
NRF13_RS12940	COG2207	Transcriptional regulator
NRF13_RS12940	COG3708	Transcriptional regulator
NRF13_RS12945	COG0563	adenylate kinase activity
NRF13_RS12950	COG2814	Major facilitator Superfamily
NRF13_RS12960	COG2318	DinB family
NRF13_RS12970	COG0561	phosphatase activity
NRF13_RS12975	COG0561	phosphatase activity
NRF13_RS12985	COG1482	cell wall glycoprotein biosynthetic process
NRF13_RS12990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRF13_RS12990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS12990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRF13_RS12995	COG3711	transcriptional antiterminator
NRF13_RS12995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS13005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRF13_RS13010	COG0583	DNA-binding transcription factor activity
NRF13_RS13015	COG2814	Major facilitator Superfamily
NRF13_RS13020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRF13_RS13020	COG2124	cytochrome p450
NRF13_RS13025	COG1309	transcriptional regulator
NRF13_RS13030	COG2226	methyltransferase
NRF13_RS13045	COG2116	formate transmembrane transporter activity
NRF13_RS13050	COG5609	conserved protein (DUF2294)
NRF13_RS13055	COG3383	formate dehydrogenase (NAD+) activity
NRF13_RS13060	COG2427	Protein of unknown function (DUF1641)
NRF13_RS13070	COG0626	cystathionine gamma-synthase activity
NRF13_RS13075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRF13_RS13100	COG0768	penicillin binding
NRF13_RS13115	COG0826	peptidase U32
NRF13_RS13120	COG0826	peptidase U32
NRF13_RS13125	COG4122	O-methyltransferase activity
NRF13_RS13130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NRF13_RS13145	COG4472	Bacterial protein of unknown function (DUF965)
NRF13_RS13155	COG0628	permease
NRF13_RS13160	COG1126	abc transporter atp-binding protein
NRF13_RS13165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS13170	COG0765	amino acid transport
NRF13_RS13175	COG0765	amino acid transport
NRF13_RS13190	COG3881	PFAM PRC-barrel domain
NRF13_RS13195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRF13_RS13200	COG0457	Tetratricopeptide repeat
NRF13_RS13210	COG1104	cysteine desulfurase activity
NRF13_RS13215	COG1959	2 iron, 2 sulfur cluster binding
NRF13_RS13220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NRF13_RS13225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NRF13_RS13250	COG3103	Sh3 type 3 domain protein
NRF13_RS13250	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS13250	COG4991	sh3 domain protein
NRF13_RS13260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRF13_RS13270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NRF13_RS13270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NRF13_RS13275	COG5416	Lipopolysaccharide assembly protein A domain
NRF13_RS13280	COG0490	domain, Protein
NRF13_RS13285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRF13_RS13285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRF13_RS13295	COG2244	polysaccharide biosynthetic process
NRF13_RS13300	COG2323	membrane
NRF13_RS13310	COG1862	Preprotein translocase
NRF13_RS13350	COG1388	LysM domain
NRF13_RS13360	COG0157	Belongs to the NadC ModD family
NRF13_RS13365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRF13_RS13370	COG1104	cysteine desulfurase activity
NRF13_RS13375	COG1827	regulation of RNA biosynthetic process
NRF13_RS13380	COG0077	Prephenate dehydratase
NRF13_RS13395	COG3290	protein histidine kinase activity
NRF13_RS13400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRF13_RS13405	COG2868	ribosomal protein
NRF13_RS13415	COG1994	Peptidase M50
NRF13_RS13420	COG0739	heme binding
NRF13_RS13425	COG2894	cell division
NRF13_RS13435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NRF13_RS13445	COG1077	Cell shape determining protein MreB Mrl
NRF13_RS13465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NRF13_RS13470	COG0285	dihydrofolate synthase activity
NRF13_RS13475	COG0525	valine-tRNA ligase activity
NRF13_RS13485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRF13_RS13490	COG1388	LysM domain
NRF13_RS13500	COG0113	porphobilinogen synthase activity
NRF13_RS13505	COG1587	Uroporphyrinogen-III synthase
NRF13_RS13515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRF13_RS13535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRF13_RS13540	COG0470	DNA polymerase III
NRF13_RS13540	COG1067	ATP-dependent peptidase activity
NRF13_RS13555	COG0457	Tetratricopeptide repeat
NRF13_RS13555	COG1477	protein flavinylation
NRF13_RS13570	COG0473	3-isopropylmalate dehydrogenase activity
NRF13_RS13585	COG0440	acetolactate synthase activity
NRF13_RS13590	COG0028	Belongs to the TPP enzyme family
NRF13_RS13615	COG0622	Phosphoesterase
NRF13_RS13620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRF13_RS13630	COG5401	PFAM Sporulation and spore germination
NRF13_RS13640	COG1846	Transcriptional regulator
NRF13_RS13645	COG2197	response regulator
NRF13_RS13650	COG0824	Thioesterase
NRF13_RS13655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRF13_RS13660	COG1053	succinate dehydrogenase
NRF13_RS13665	COG2009	succinate dehydrogenase
NRF13_RS13670	COG1719	4-vinyl reductase, 4VR
NRF13_RS13675	COG0527	aspartate kinase activity
NRF13_RS13685	COG3118	belongs to the thioredoxin family
NRF13_RS13690	COG3534	alpha-L-arabinofuranosidase
NRF13_RS13695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NRF13_RS13700	COG2086	electron transfer activity
NRF13_RS13705	COG1024	Enoyl-CoA hydratase
NRF13_RS13710	COG1309	transcriptional regulator
NRF13_RS13715	COG0318	PFAM AMP-dependent synthetase and ligase
NRF13_RS13725	COG3766	membrane
NRF13_RS13735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRF13_RS13735	COG1796	DNA polymerase
NRF13_RS13740	COG1286	toxin biosynthetic process
NRF13_RS13755	COG0072	phenylalanine-tRNA ligase activity
NRF13_RS13755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRF13_RS13760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRF13_RS13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRF13_RS13775	COG3835	regulator
NRF13_RS13780	COG0277	FAD linked oxidase domain protein
NRF13_RS13785	COG0247	lactate metabolic process
NRF13_RS13790	COG1966	Carbon starvation protein
NRF13_RS13795	COG3534	alpha-L-arabinofuranosidase
NRF13_RS13800	COG0395	ABC-type sugar transport system, permease component
NRF13_RS13805	COG1175	transmembrane transport
NRF13_RS13810	COG1653	transport
NRF13_RS13820	COG0647	UMP catabolic process
NRF13_RS13825	COG0235	Class ii aldolase
NRF13_RS13830	COG1069	ribulokinase activity
NRF13_RS13835	COG2160	L-arabinose isomerase activity
NRF13_RS13840	COG3507	Belongs to the glycosyl hydrolase 43 family
NRF13_RS13845	COG1363	Peptidase, m42
NRF13_RS13855	COG3326	Membrane
NRF13_RS13860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRF13_RS13870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRF13_RS13875	COG1346	cytolysis
NRF13_RS13880	COG1380	Effector of murein hydrolase LrgA
NRF13_RS13885	COG3279	Response regulator of the LytR AlgR family
NRF13_RS13890	COG3275	phosphorelay sensor kinase activity
NRF13_RS13895	COG1011	Hydrolase
NRF13_RS13910	COG0398	Pfam SNARE associated Golgi protein
NRF13_RS13915	COG1484	DNA-dependent DNA replication
NRF13_RS13920	COG3611	Membrane attachment protein
NRF13_RS13935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRF13_RS13940	COG1733	regulation of RNA biosynthetic process
NRF13_RS13945	COG2814	Major facilitator Superfamily
NRF13_RS13950	COG0656	L-ascorbic acid biosynthetic process
NRF13_RS13955	COG0237	dephospho-CoA kinase activity
NRF13_RS13960	COG1971	Probably functions as a manganese efflux pump
NRF13_RS13965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRF13_RS13970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRF13_RS13970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRF13_RS13975	COG5002	protein histidine kinase activity
NRF13_RS13980	COG0745	RESPONSE REGULATOR receiver
NRF13_RS13990	COG0538	isocitrate dehydrogenase activity
NRF13_RS13995	COG0372	Belongs to the citrate synthase family
NRF13_RS14015	COG0628	permease
NRF13_RS14020	COG3030	protein affecting phage T7 exclusion by the F plasmid
NRF13_RS14025	COG0469	pyruvate kinase activity
NRF13_RS14045	COG0281	malic enzyme
NRF13_RS14050	COG0587	DNA-directed DNA polymerase activity
NRF13_RS14070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NRF13_RS14080	COG4109	DRTGG domain
NRF13_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS14110	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRF13_RS14120	COG0827	DNA restriction-modification system
NRF13_RS14125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NRF13_RS14130	COG3874	Sporulation protein YtfJ
NRF13_RS14140	COG1714	RDD family
NRF13_RS14145	COG0616	signal peptide processing
NRF13_RS14150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRF13_RS14155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NRF13_RS14160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRF13_RS14175	COG1104	cysteine desulfurase activity
NRF13_RS14180	COG1114	Component of the transport system for branched-chain amino acids
NRF13_RS14190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRF13_RS14195	COG1309	transcriptional regulator
NRF13_RS14200	COG1956	GAF domain-containing protein
NRF13_RS14205	COG2199	diguanylate cyclase activity
NRF13_RS14205	COG2203	Gaf domain
NRF13_RS14215	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS14220	COG4282	regulation of fungal-type cell wall biogenesis
NRF13_RS14255	COG1017	nitric oxide dioxygenase activity
NRF13_RS14255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRF13_RS14285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NRF13_RS14290	COG1378	Sugar-specific transcriptional regulator TrmB
NRF13_RS14310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRF13_RS14315	COG0454	-acetyltransferase
NRF13_RS14320	COG0517	IMP dehydrogenase activity
NRF13_RS14325	COG0123	including yeast histone deacetylase and acetoin utilization protein
NRF13_RS14330	COG1360	Flagellar Motor Protein
NRF13_RS14335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NRF13_RS14340	COG1609	Transcriptional regulator
NRF13_RS14345	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NRF13_RS14345	COG1605	Chorismate mutase
NRF13_RS14350	COG3118	belongs to the thioredoxin family
NRF13_RS14355	COG4980	gas vesicle protein
NRF13_RS14360	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NRF13_RS14370	COG1674	ftsk spoiiie
NRF13_RS14375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRF13_RS14385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS14395	COG1363	Peptidase, m42
NRF13_RS14400	COG5584	Small secreted protein
NRF13_RS14405	COG0281	malic enzyme
NRF13_RS14410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRF13_RS14425	COG0510	thiamine kinase activity
NRF13_RS14430	COG1597	lipid kinase activity
NRF13_RS14440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NRF13_RS14445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRF13_RS14450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRF13_RS14455	COG2252	PERMEase
NRF13_RS14460	COG4473	ABC transporter
NRF13_RS14465	COG1131	(ABC) transporter
NRF13_RS14470	COG1349	DNA-binding transcription factor activity
NRF13_RS14475	COG1187	pseudouridine synthase activity
NRF13_RS14480	COG2244	polysaccharide biosynthetic process
NRF13_RS14485	COG2081	HI0933 family
NRF13_RS14490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NRF13_RS14500	COG1609	Transcriptional regulator
NRF13_RS14505	COG1653	transport
NRF13_RS14510	COG1175	transmembrane transport
NRF13_RS14515	COG0395	ABC-type sugar transport system, permease component
NRF13_RS14520	COG1486	melibiose metabolic process
NRF13_RS14530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRF13_RS14545	COG1366	Belongs to the anti-sigma-factor antagonist family
NRF13_RS14545	COG2202	Pas domain
NRF13_RS14550	COG2814	Major facilitator Superfamily
NRF13_RS14555	COG5522	Integral membrane protein (intg_mem_TP0381)
NRF13_RS14560	COG0577	efflux transmembrane transporter activity
NRF13_RS14565	COG1136	(ABC) transporter
NRF13_RS14570	COG2205	protein histidine kinase activity
NRF13_RS14575	COG0745	RESPONSE REGULATOR receiver
NRF13_RS14580	COG0577	efflux transmembrane transporter activity
NRF13_RS14585	COG1136	(ABC) transporter
NRF13_RS14605	COG1131	(ABC) transporter
NRF13_RS14610	COG1725	Transcriptional regulator
NRF13_RS14625	COG1242	4 iron, 4 sulfur cluster binding
NRF13_RS14630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NRF13_RS14640	COG0584	glycerophosphoryl diester phosphodiesterase
NRF13_RS14650	COG2267	carboxylic ester hydrolase activity
NRF13_RS14655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NRF13_RS14660	COG1113	amino acid transport
NRF13_RS14665	COG0367	asparagine synthase
NRF13_RS14685	COG1506	peptidase
NRF13_RS14690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NRF13_RS14695	COG1116	anion transmembrane transporter activity
NRF13_RS14700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRF13_RS14705	COG0494	nUDIX hydrolase
NRF13_RS14710	COG4824	toxin secretion phage lysis holin
NRF13_RS14715	COG0783	Belongs to the Dps family
NRF13_RS14740	COG0288	reversible hydration of carbon dioxide
NRF13_RS14750	COG1271	oxidase subunit
NRF13_RS14755	COG1294	oxidase, subunit
NRF13_RS14765	COG4948	Mandelate Racemase Muconate Lactonizing
NRF13_RS14775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NRF13_RS14780	COG0596	Alpha beta hydrolase
NRF13_RS14790	COG1169	isochorismate synthase
NRF13_RS14795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NRF13_RS14800	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NRF13_RS14925	COG3859	Proton-coupled thiamine transporter YuaJ
NRF13_RS14930	COG2268	Band 7 protein
NRF13_RS14935	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRF13_RS14940	COG2318	DinB family
NRF13_RS14950	COG1454	alcohol dehydrogenase
NRF13_RS14955	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS14960	COG1510	regulation of RNA biosynthetic process
NRF13_RS14970	COG0569	domain protein
NRF13_RS14975	COG1705	Flagellar rod assembly protein muramidase FlgJ
NRF13_RS14980	COG1017	nitric oxide dioxygenase activity
NRF13_RS14980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRF13_RS15005	COG0457	Tetratricopeptide repeat
NRF13_RS15025	COG5444	nuclease activity
NRF13_RS15030	COG4282	regulation of fungal-type cell wall biogenesis
NRF13_RS15055	COG0628	permease
NRF13_RS15060	COG0673	inositol 2-dehydrogenase activity
NRF13_RS15065	COG0693	protein deglycase activity
NRF13_RS15070	COG0840	transmembrane signaling receptor activity
NRF13_RS15075	COG0840	transmembrane signaling receptor activity
NRF13_RS15080	COG0840	transmembrane signaling receptor activity
NRF13_RS15085	COG0840	transmembrane signaling receptor activity
NRF13_RS15105	COG0432	Pfam Uncharacterised protein family UPF0047
NRF13_RS15110	COG0366	Alpha amylase catalytic
NRF13_RS15115	COG1253	flavin adenine dinucleotide binding
NRF13_RS15120	COG2738	Putative neutral zinc metallopeptidase
NRF13_RS15135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRF13_RS15160	COG1335	isochorismatase
NRF13_RS15165	COG1979	alcohol dehydrogenase
NRF13_RS15170	COG1979	alcohol dehydrogenase
NRF13_RS15175	COG2155	Conserved Protein
NRF13_RS15180	COG1098	S1 RNA binding domain
NRF13_RS15185	COG0436	Aminotransferase
NRF13_RS15190	COG1522	sequence-specific DNA binding
NRF13_RS15195	COG2267	carboxylic ester hydrolase activity
NRF13_RS15205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRF13_RS15210	COG2205	protein histidine kinase activity
NRF13_RS15220	COG5018	Exonuclease
NRF13_RS15225	COG2814	Major facilitator Superfamily
NRF13_RS15230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRF13_RS15235	COG3011	Protein conserved in bacteria
NRF13_RS15245	COG3290	protein histidine kinase activity
NRF13_RS15250	COG4565	transcriptional regulatory protein
NRF13_RS15255	COG1744	ABC transporter substrate-binding protein PnrA-like
NRF13_RS15260	COG3845	ABC transporter
NRF13_RS15265	COG4603	Belongs to the binding-protein-dependent transport system permease family
NRF13_RS15270	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRF13_RS15280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NRF13_RS15280	COG2111	Na H antiporter
NRF13_RS15285	COG2111	Na H antiporter
NRF13_RS15290	COG1006	Multisubunit Na H antiporter MnhC subunit
NRF13_RS15295	COG0651	ATP synthesis coupled electron transport
NRF13_RS15300	COG1863	multisubunit Na H antiporter MnhE subunit
NRF13_RS15305	COG2212	antiporter activity
NRF13_RS15310	COG1320	monovalent cation:proton antiporter activity
NRF13_RS15315	COG2050	protein possibly involved in aromatic compounds catabolism
NRF13_RS15320	COG2197	response regulator
NRF13_RS15325	COG4585	Histidine kinase
NRF13_RS15335	COG0142	geranyltranstransferase activity
NRF13_RS15350	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NRF13_RS15355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NRF13_RS15360	COG1335	isochorismatase
NRF13_RS15365	COG5506	Protein of unknown function (DUF1694)
NRF13_RS15380	COG0628	permease
NRF13_RS15390	COG1418	mRNA catabolic process
NRF13_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS15405	COG2508	Transcriptional regulator
NRF13_RS15405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NRF13_RS15410	COG0686	Belongs to the AlaDH PNT family
NRF13_RS15415	COG5634	Uncharacterized conserved protein (DUF2278)
NRF13_RS15420	COG3251	PFAM MbtH domain protein
NRF13_RS15425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRF13_RS15430	COG1535	isochorismatase
NRF13_RS15430	COG3433	isochorismatase activity
NRF13_RS15435	COG1021	2,3-dihydroxybenzoate-AMP ligase
NRF13_RS15440	COG1169	isochorismate synthase
NRF13_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS15450	COG2819	hydrolase of the alpha beta superfamily
NRF13_RS15455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NRF13_RS15460	COG1268	BioY protein
NRF13_RS15465	COG2056	Na+-H+ antiporter family
NRF13_RS15475	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NRF13_RS15480	COG3584	3D domain protein
NRF13_RS15495	COG1252	NADH dehydrogenase
NRF13_RS15525	COG1131	(ABC) transporter
NRF13_RS15550	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NRF13_RS15555	COG0316	Belongs to the HesB IscA family
NRF13_RS15565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRF13_RS15575	COG1252	NADH dehydrogenase
NRF13_RS15580	COG4837	Protein of unknown function (DUF1462)
NRF13_RS15585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NRF13_RS15590	COG0823	Involved in the tonB-independent uptake of proteins
NRF13_RS15590	COG1506	peptidase
NRF13_RS15590	COG4946	Tricorn protease homolog
NRF13_RS15600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRF13_RS15605	COG0460	homoserine dehydrogenase
NRF13_RS15610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NRF13_RS15615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NRF13_RS15620	COG0647	UMP catabolic process
NRF13_RS15625	COG2445	Protein of unknown function DUF86
NRF13_RS15630	COG4470	Protein conserved in bacteria
NRF13_RS15640	COG0739	heme binding
NRF13_RS15650	COG0737	Belongs to the 5'-nucleotidase family
NRF13_RS15655	COG0730	response to heat
NRF13_RS15660	COG1801	Protein of unknown function DUF72
NRF13_RS15675	COG2508	Transcriptional regulator
NRF13_RS15705	COG2814	Major facilitator Superfamily
NRF13_RS15710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRF13_RS15715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRF13_RS15720	COG2356	endonuclease I
NRF13_RS15725	COG3842	ATPase activity
NRF13_RS15730	COG2188	Transcriptional regulator
NRF13_RS15735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRF13_RS15740	COG0395	ABC-type sugar transport system, permease component
NRF13_RS15745	COG1175	transmembrane transport
NRF13_RS15750	COG1653	transport
NRF13_RS15755	COG2222	sugar isomerase
NRF13_RS15760	COG0789	Transcriptional regulator
NRF13_RS15785	COG0322	excinuclease ABC activity
NRF13_RS15790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRF13_RS15795	COG2226	methyltransferase
NRF13_RS15805	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS15810	COG0719	Fe-S assembly protein
NRF13_RS15815	COG0822	iron-sulfur transferase activity
NRF13_RS15820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRF13_RS15825	COG0719	Fe-S assembly protein
NRF13_RS15830	COG0396	ATPase activity
NRF13_RS15840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRF13_RS15845	COG1464	Belongs to the NlpA lipoprotein family
NRF13_RS15850	COG2011	ABC-type metal ion transport system permease component
NRF13_RS15855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRF13_RS15865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRF13_RS15870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NRF13_RS15885	COG1393	Belongs to the ArsC family
NRF13_RS15890	COG1960	acyl-CoA dehydrogenase activity
NRF13_RS15895	COG0183	Belongs to the thiolase family
NRF13_RS15900	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRF13_RS15900	COG1024	Enoyl-CoA hydratase
NRF13_RS15920	COG5577	PFAM Coat F domain
NRF13_RS15925	COG1846	Transcriptional regulator
NRF13_RS15930	COG0477	Major facilitator Superfamily
NRF13_RS15935	COG0583	DNA-binding transcription factor activity
NRF13_RS15955	COG1120	ATPase activity
NRF13_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS15975	COG0783	Belongs to the Dps family
NRF13_RS15980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRF13_RS15985	COG0745	RESPONSE REGULATOR receiver
NRF13_RS15990	COG2770	Histidine kinase
NRF13_RS15990	COG2205	protein histidine kinase activity
NRF13_RS16000	COG1309	transcriptional regulator
NRF13_RS16005	COG0114	fumarate hydratase activity
NRF13_RS16015	COG0697	spore germination
NRF13_RS16020	COG0814	amino acid
NRF13_RS16030	COG2197	response regulator
NRF13_RS16035	COG4585	Histidine kinase
NRF13_RS16040	COG4758	membrane
NRF13_RS16045	COG3595	metallopeptidase activity
NRF13_RS16050	COG1842	Phage shock protein A
NRF13_RS16055	COG4758	membrane
NRF13_RS16060	COG2814	Major facilitator Superfamily
NRF13_RS16065	COG2096	Adenosyltransferase
NRF13_RS16070	COG1120	ATPase activity
NRF13_RS16075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS16080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRF13_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS16090	COG3386	PFAM SMP-30 Gluconolaconase
NRF13_RS16095	COG2205	protein histidine kinase activity
NRF13_RS16100	COG0745	RESPONSE REGULATOR receiver
NRF13_RS16110	COG1191	sigma factor activity
NRF13_RS16120	COG2140	Oxalate decarboxylase
NRF13_RS16130	COG1120	ATPase activity
NRF13_RS16135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS16140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS16145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRF13_RS16150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NRF13_RS16155	COG0531	amino acid
NRF13_RS16165	COG1988	membrane-bound metal-dependent
NRF13_RS16170	COG1368	sulfuric ester hydrolase activity
NRF13_RS16175	COG1910	domain protein
NRF13_RS16180	COG0725	ABC transporter, periplasmic molybdate-binding protein
NRF13_RS16185	COG4149	molybdate abc transporter
NRF13_RS16190	COG2197	response regulator
NRF13_RS16195	COG3850	Histidine kinase
NRF13_RS16200	COG1131	(ABC) transporter
NRF13_RS16210	COG0842	Transport permease protein
NRF13_RS16215	COG0656	L-ascorbic acid biosynthetic process
NRF13_RS16235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NRF13_RS16240	COG3973	AAA domain
NRF13_RS16245	COG2860	membrane
NRF13_RS16255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NRF13_RS16260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRF13_RS16265	COG2217	Heavy metal translocating P-type atpase
NRF13_RS16270	COG2217	Heavy metal translocating P-type atpase
NRF13_RS16275	COG2608	mercury ion transmembrane transporter activity
NRF13_RS16280	COG1937	Protein conserved in bacteria
NRF13_RS16285	COG0673	inositol 2-dehydrogenase activity
NRF13_RS16300	COG2814	Major facilitator Superfamily
NRF13_RS16315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS16320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NRF13_RS16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS16330	COG1126	abc transporter atp-binding protein
NRF13_RS16335	COG0765	amino acid transport
NRF13_RS16340	COG0765	amino acid transport
NRF13_RS16345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS16350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRF13_RS16355	COG0454	-acetyltransferase
NRF13_RS16360	COG0583	DNA-binding transcription factor activity
NRF13_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS16370	COG2732	(Barnase) inhibitor
NRF13_RS16385	COG0557	exoribonuclease II activity
NRF13_RS16390	COG1647	Serine aminopeptidase, S33
NRF13_RS16395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRF13_RS16400	COG1476	TRANSCRIPTIONal
NRF13_RS16405	COG1396	sequence-specific DNA binding
NRF13_RS16410	COG1396	sequence-specific DNA binding
NRF13_RS16415	COG1733	regulation of RNA biosynthetic process
NRF13_RS16440	COG1131	(ABC) transporter
NRF13_RS16445	COG1174	glycine betaine transport
NRF13_RS16450	COG1732	Glycine betaine
NRF13_RS16455	COG1174	glycine betaine transport
NRF13_RS16460	COG0517	IMP dehydrogenase activity
NRF13_RS16460	COG1125	glycine betaine transport
NRF13_RS16465	COG1510	regulation of RNA biosynthetic process
NRF13_RS16470	COG1174	glycine betaine transport
NRF13_RS16475	COG1732	Glycine betaine
NRF13_RS16480	COG1174	glycine betaine transport
NRF13_RS16485	COG0517	IMP dehydrogenase activity
NRF13_RS16485	COG1125	glycine betaine transport
NRF13_RS16490	COG1510	regulation of RNA biosynthetic process
NRF13_RS16495	COG2095	MarC family integral membrane protein
NRF13_RS16500	COG3064	Membrane
NRF13_RS16505	COG4640	response to antibiotic
NRF13_RS16510	COG0456	acetyltransferase
NRF13_RS16525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRF13_RS16540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRF13_RS16545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRF13_RS16550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRF13_RS16560	COG2234	aminopeptidase activity
NRF13_RS16580	COG0126	phosphoglycerate kinase activity
NRF13_RS16585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRF13_RS16590	COG2390	Transcriptional regulator
NRF13_RS16595	COG2814	Major facilitator Superfamily
NRF13_RS16600	COG1609	Transcriptional regulator
NRF13_RS16605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS16615	COG0583	DNA-binding transcription factor activity
NRF13_RS16620	COG0697	spore germination
NRF13_RS16625	COG1113	amino acid transport
NRF13_RS16635	COG1737	Transcriptional regulator
NRF13_RS16640	COG1070	Carbohydrate kinase
NRF13_RS16665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS16670	COG2186	Transcriptional regulator
NRF13_RS16675	COG1620	l-lactate permease
NRF13_RS16680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NRF13_RS16690	COG5039	Polysaccharide pyruvyl transferase
NRF13_RS16695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRF13_RS16700	COG0110	maltose O-acetyltransferase activity
NRF13_RS16705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRF13_RS16710	COG2244	polysaccharide biosynthetic process
NRF13_RS16715	COG1216	Glycosyl transferase, family 2
NRF13_RS16720	COG5039	Polysaccharide pyruvyl transferase
NRF13_RS16725	COG1216	Glycosyl transferase, family 2
NRF13_RS16735	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS16740	COG1215	transferase activity, transferring glycosyl groups
NRF13_RS16745	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS16750	COG1086	Polysaccharide biosynthesis protein
NRF13_RS16755	COG0489	protein tyrosine kinase activity
NRF13_RS16760	COG3944	biosynthesis protein
NRF13_RS16765	COG1396	sequence-specific DNA binding
NRF13_RS16770	COG2272	Belongs to the type-B carboxylesterase lipase family
NRF13_RS16780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRF13_RS16785	COG2364	Membrane
NRF13_RS16790	COG0456	acetyltransferase
NRF13_RS16795	COG3479	Phenolic acid decarboxylase
NRF13_RS16855	COG2223	nitrite transmembrane transporter activity
NRF13_RS16860	COG1609	Transcriptional regulator
NRF13_RS16870	COG0583	DNA-binding transcription factor activity
NRF13_RS16875	COG2828	Protein conserved in bacteria
NRF13_RS16880	COG0477	Major facilitator Superfamily
NRF13_RS16880	COG2814	Major facilitator Superfamily
NRF13_RS16885	COG1611	Belongs to the LOG family
NRF13_RS16890	COG1694	Mazg nucleotide pyrophosphohydrolase
NRF13_RS16895	COG0659	secondary active sulfate transmembrane transporter activity
NRF13_RS16900	COG0288	reversible hydration of carbon dioxide
NRF13_RS16905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRF13_RS16910	COG4290	ribonuclease
NRF13_RS16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NRF13_RS16920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS16930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NRF13_RS16940	COG1051	belongs to the nudix hydrolase family
NRF13_RS16945	COG0492	ferredoxin-NADP+ reductase activity
NRF13_RS16950	COG0791	NLP P60 protein
NRF13_RS16950	COG3883	PFAM NLP P60 protein
NRF13_RS16960	COG0457	Tetratricopeptide repeat
NRF13_RS16965	COG5002	protein histidine kinase activity
NRF13_RS16970	COG0745	RESPONSE REGULATOR receiver
NRF13_RS16980	COG1132	(ABC) transporter
NRF13_RS16985	COG0140	phosphoribosyl-ATP diphosphatase activity
NRF13_RS16985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRF13_RS17010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRF13_RS17025	COG4990	cell redox homeostasis
NRF13_RS17030	COG0110	maltose O-acetyltransferase activity
NRF13_RS17050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NRF13_RS17060	COG2188	Transcriptional regulator
NRF13_RS17065	COG1309	transcriptional regulator
NRF13_RS17070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NRF13_RS17075	COG1950	PFAM Membrane protein of
NRF13_RS17080	COG1983	PspC domain protein
NRF13_RS17085	COG3595	metallopeptidase activity
NRF13_RS17100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRF13_RS17110	COG4897	Protein conserved in bacteria
NRF13_RS17115	COG0574	Belongs to the PEP-utilizing enzyme family
NRF13_RS17115	COG3848	Pyruvate phosphate dikinase
NRF13_RS17120	COG1309	transcriptional regulator
NRF13_RS17125	COG2814	Major facilitator Superfamily
NRF13_RS17145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NRF13_RS17155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRF13_RS17165	COG3409	Peptidoglycan-binding domain 1 protein
NRF13_RS17165	COG0793	Belongs to the peptidase S41A family
NRF13_RS17170	COG3420	alginic acid biosynthetic process
NRF13_RS17175	COG2177	Part of the ABC transporter FtsEX involved in
NRF13_RS17180	COG2884	Cell division ATP-binding protein ftsE
NRF13_RS17185	COG2010	Cytochrome c
NRF13_RS17190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS17205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRF13_RS17220	COG1516	flagellar protein fliS
NRF13_RS17225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NRF13_RS17230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRF13_RS17250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NRF13_RS17255	COG4786	Flagellar basal body rod
NRF13_RS17255	COG1256	bacterial-type flagellum assembly
NRF13_RS17260	COG3418	PFAM FlgN family protein
NRF13_RS17265	COG2747	anti-sigma28 factor FlgM
NRF13_RS17275	COG1040	competence protein
NRF13_RS17285	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NRF13_RS17290	COG1307	EDD domain protein, DegV family
NRF13_RS17295	COG2197	response regulator
NRF13_RS17300	COG4585	Histidine kinase
NRF13_RS17305	COG1739	Uncharacterized protein family UPF0029
NRF13_RS17310	COG1316	TRANSCRIPTIONal
NRF13_RS17315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRF13_RS17320	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS17325	COG1215	transferase activity, transferring glycosyl groups
NRF13_RS17330	COG3206	protein involved in exopolysaccharide biosynthesis
NRF13_RS17335	COG3307	-O-antigen
NRF13_RS17340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NRF13_RS17345	COG0297	glycogen (starch) synthase activity
NRF13_RS17345	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS17350	COG2244	polysaccharide biosynthetic process
NRF13_RS17360	COG2247	cell wall binding repeat
NRF13_RS17360	COG0860	N-Acetylmuramoyl-L-alanine amidase
NRF13_RS17365	COG2385	sporulation resulting in formation of a cellular spore
NRF13_RS17365	COG2247	cell wall binding repeat
NRF13_RS17375	COG1316	TRANSCRIPTIONal
NRF13_RS17380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NRF13_RS17385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRF13_RS17390	COG1134	teichoic acid transport
NRF13_RS17395	COG1682	transport, permease protein
NRF13_RS17400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NRF13_RS17410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRF13_RS17415	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NRF13_RS17420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NRF13_RS17425	COG4193	domain, Protein
NRF13_RS17430	COG1482	cell wall glycoprotein biosynthetic process
NRF13_RS17435	COG0697	spore germination
NRF13_RS17440	COG0814	amino acid
NRF13_RS17450	COG1215	transferase activity, transferring glycosyl groups
NRF13_RS17455	COG2814	Major facilitator Superfamily
NRF13_RS17460	COG1316	TRANSCRIPTIONal
NRF13_RS17465	COG0561	phosphatase activity
NRF13_RS17470	COG2433	Pfam Transposase IS66
NRF13_RS17475	COG0791	NLP P60 protein
NRF13_RS17485	COG2843	Capsule synthesis protein
NRF13_RS17495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRF13_RS17500	COG0697	spore germination
NRF13_RS17505	COG0814	amino acid
NRF13_RS17515	COG1609	Transcriptional regulator
NRF13_RS17520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRF13_RS17530	COG1129	ABC transporter
NRF13_RS17535	COG1172	Belongs to the binding-protein-dependent transport system permease family
NRF13_RS17540	COG1879	ABC-type sugar transport system periplasmic component
NRF13_RS17545	COG3103	Sh3 type 3 domain protein
NRF13_RS17550	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRF13_RS17555	COG3527	Alpha-acetolactate decarboxylase
NRF13_RS17560	COG0028	Belongs to the TPP enzyme family
NRF13_RS17565	COG0583	DNA-binding transcription factor activity
NRF13_RS17570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NRF13_RS17585	COG5337	Spore coat protein CotH
NRF13_RS17595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NRF13_RS17605	COG0405	Gamma-glutamyltransferase
NRF13_RS17610	COG1522	sequence-specific DNA binding
NRF13_RS17615	COG2059	Chromate
NRF13_RS17620	COG2059	Chromate
NRF13_RS17630	COG0655	NAD(P)H dehydrogenase (quinone) activity
NRF13_RS17635	COG0583	DNA-binding transcription factor activity
NRF13_RS17645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NRF13_RS17650	COG4464	protein tyrosine phosphatase activity
NRF13_RS17655	COG0489	protein tyrosine kinase activity
NRF13_RS17660	COG3944	biosynthesis protein
NRF13_RS17670	COG4715	Zinc finger, swim domain protein
NRF13_RS17675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRF13_RS17680	COG0561	phosphatase activity
NRF13_RS17685	COG1349	DNA-binding transcription factor activity
NRF13_RS17690	COG0629	single-stranded DNA binding
NRF13_RS17715	COG0457	Tetratricopeptide repeat
NRF13_RS17720	COG4786	Flagellar basal body rod
NRF13_RS17725	COG4786	Flagellar basal body rod
NRF13_RS17730	COG1077	Cell shape determining protein MreB Mrl
NRF13_RS17735	COG1609	Transcriptional regulator
NRF13_RS17740	COG1846	Transcriptional regulator
NRF13_RS17745	COG2814	Major facilitator Superfamily
NRF13_RS17750	COG1953	Uracil, thiamine, allantoin
NRF13_RS17755	COG0477	Major facilitator Superfamily
NRF13_RS17760	COG1335	isochorismatase
NRF13_RS17765	COG0004	ammonium transporteR
NRF13_RS17770	COG0347	Belongs to the P(II) protein family
NRF13_RS17775	COG0772	Belongs to the SEDS family
NRF13_RS17780	COG0671	phosphoesterase, PA-phosphatase related
NRF13_RS17790	COG0739	heme binding
NRF13_RS17795	COG1247	-acetyltransferase
NRF13_RS17810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRF13_RS17820	COG0726	polysaccharide deacetylase
NRF13_RS17830	COG1959	2 iron, 2 sulfur cluster binding
NRF13_RS17845	COG0831	urea catabolic process
NRF13_RS17850	COG3237	CsbD-like
NRF13_RS17855	COG1994	Peptidase M50
NRF13_RS17860	COG0457	Tetratricopeptide repeat
NRF13_RS17870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRF13_RS17880	COG2304	oxidoreductase activity
NRF13_RS17885	COG2304	oxidoreductase activity
NRF13_RS17890	COG2385	sporulation resulting in formation of a cellular spore
NRF13_RS17895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRF13_RS17905	COG4836	Membrane
NRF13_RS17975	COG0698	ribose 5-phosphate isomerase
NRF13_RS17980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRF13_RS17990	COG0009	L-threonylcarbamoyladenylate synthase
NRF13_RS17995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRF13_RS18015	COG2890	protein-(glutamine-N5) methyltransferase activity
NRF13_RS18020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRF13_RS18025	COG0346	lactoylglutathione lyase activity
NRF13_RS18030	COG0789	Transcriptional regulator
NRF13_RS18035	COG0679	Auxin Efflux Carrier
NRF13_RS18040	COG0281	malic enzyme
NRF13_RS18055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NRF13_RS18065	COG1494	fructose-1,6-bisphosphatase
NRF13_RS18070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRF13_RS18080	COG0191	fructose-bisphosphate aldolase activity
NRF13_RS18085	COG2204	response regulator
NRF13_RS18090	COG4821	SIS domain
NRF13_RS18105	COG0247	lactate metabolic process
NRF13_RS18105	COG2181	nitrate reductase activity
NRF13_RS18110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRF13_RS18125	COG1132	(ABC) transporter
NRF13_RS18130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NRF13_RS18140	COG2181	nitrate reductase activity
NRF13_RS18145	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NRF13_RS18150	COG1140	nitrate reductase beta subunit
NRF13_RS18155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NRF13_RS18160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRF13_RS18170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRF13_RS18175	COG2223	nitrite transmembrane transporter activity
NRF13_RS18185	COG4506	Protein conserved in bacteria
NRF13_RS18190	COG0457	Tetratricopeptide repeat
NRF13_RS18200	COG0010	Belongs to the arginase family
NRF13_RS18205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NRF13_RS18210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRF13_RS18225	COG1994	Peptidase M50
NRF13_RS18230	COG1942	4-Oxalocrotonate Tautomerase
NRF13_RS18235	COG1846	Transcriptional regulator
NRF13_RS18240	COG0531	amino acid
NRF13_RS18245	COG3465	dGTPase activity
NRF13_RS18250	COG1078	dGTPase activity
NRF13_RS18265	COG1695	Transcriptional regulator
NRF13_RS18285	COG0583	DNA-binding transcription factor activity
NRF13_RS18290	COG2855	membrane
NRF13_RS18295	COG0280	phosphate acetyltransferase
NRF13_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS18310	COG0436	Aminotransferase
NRF13_RS18340	COG2814	Major facilitator Superfamily
NRF13_RS18345	COG2814	Major facilitator Superfamily
NRF13_RS18350	COG0833	amino acid
NRF13_RS18355	COG4187	Peptidase family M20/M25/M40
NRF13_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS18365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NRF13_RS18375	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NRF13_RS18380	COG1091	dTDP-4-dehydrorhamnose reductase activity
NRF13_RS18385	COG1088	dTDP-glucose 4,6-dehydratase activity
NRF13_RS18390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NRF13_RS18395	COG3980	spore coat polysaccharide biosynthesis protein
NRF13_RS18400	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NRF13_RS18405	COG2089	acid synthase
NRF13_RS18410	COG0456	acetyltransferase
NRF13_RS18415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRF13_RS18420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NRF13_RS18425	COG0463	Glycosyl transferase, family 2
NRF13_RS18435	COG2363	Small membrane protein
NRF13_RS18440	COG2233	PERMEase
NRF13_RS18455	COG1216	Glycosyl transferase, family 2
NRF13_RS18470	COG1695	Transcriptional regulator
NRF13_RS18475	COG0351	phosphomethylpyrimidine kinase
NRF13_RS18485	COG1621	beta-fructofuranosidase activity
NRF13_RS18490	COG1263	PTS System
NRF13_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRF13_RS18495	COG3711	transcriptional antiterminator
NRF13_RS18505	COG1404	Belongs to the peptidase S8 family
NRF13_RS18510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRF13_RS18515	COG0778	Nitroreductase
NRF13_RS18520	COG0772	Belongs to the SEDS family
NRF13_RS18525	COG0454	-acetyltransferase
NRF13_RS18545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRF13_RS18550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRF13_RS18555	COG2261	transglycosylase associated protein
NRF13_RS18560	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NRF13_RS18565	COG2246	polysaccharide biosynthetic process
NRF13_RS18570	COG1309	transcriptional regulator
NRF13_RS18590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NRF13_RS18595	COG2837	iron assimilation
NRF13_RS18615	COG0583	DNA-binding transcription factor activity
NRF13_RS18625	COG1346	cytolysis
NRF13_RS18630	COG4895	conserved protein (DUF2196)
NRF13_RS18635	COG0789	Transcriptional regulator
NRF13_RS18640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NRF13_RS18645	COG0346	lactoylglutathione lyase activity
NRF13_RS18650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS18655	COG1404	Belongs to the peptidase S8 family
NRF13_RS18660	COG1442	glycosyl transferase family 8
NRF13_RS18665	COG2357	RelA SpoT domain protein
NRF13_RS18670	COG1575	Belongs to the MenA family. Type 1 subfamily
NRF13_RS18685	COG1696	Membrane protein involved in D-alanine export
NRF13_RS18695	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NRF13_RS18700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRF13_RS18705	COG1486	melibiose metabolic process
NRF13_RS18710	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRF13_RS18715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS18720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS18725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRF13_RS18725	COG3711	transcriptional antiterminator
NRF13_RS18740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRF13_RS18755	COG0640	Transcriptional regulator
NRF13_RS18760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NRF13_RS18765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS18770	COG1447	Phosphotransferase system cellobiose-specific component IIA
NRF13_RS18775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NRF13_RS18780	COG2723	6-phospho-beta-galactosidase activity
NRF13_RS18785	COG1940	carbohydrate kinase activity
NRF13_RS18790	COG1482	cell wall glycoprotein biosynthetic process
NRF13_RS18800	COG0753	catalase activity
NRF13_RS18805	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NRF13_RS18810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NRF13_RS18815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NRF13_RS18820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NRF13_RS18825	COG4988	ABC transporter
NRF13_RS18830	COG1294	oxidase, subunit
NRF13_RS18835	COG1271	oxidase subunit
NRF13_RS18840	COG3493	citrate carrier protein
NRF13_RS18845	COG0726	polysaccharide deacetylase
NRF13_RS18850	COG3842	ATPase activity
NRF13_RS18855	COG2508	Transcriptional regulator
NRF13_RS18860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS18870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NRF13_RS18885	COG4894	glucomannan catabolic process
NRF13_RS18890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NRF13_RS18895	COG0500	methyltransferase
NRF13_RS18900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRF13_RS18915	COG0753	catalase activity
NRF13_RS18915	COG0693	protein deglycase activity
NRF13_RS18920	COG2851	Citrate transporter
NRF13_RS18925	COG2273	Hydrolase Family 16
NRF13_RS18935	COG2270	Major facilitator Superfamily
NRF13_RS18940	COG0513	Belongs to the DEAD box helicase family
NRF13_RS19005	COG0697	spore germination
NRF13_RS19010	COG0589	response to stress
NRF13_RS19075	COG0010	Belongs to the arginase family
NRF13_RS19080	COG0833	amino acid
NRF13_RS19085	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NRF13_RS19090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NRF13_RS19100	COG2390	Transcriptional regulator
NRF13_RS19105	COG0561	phosphatase activity
NRF13_RS19135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRF13_RS19140	COG5294	Protein conserved in bacteria
NRF13_RS19145	COG0577	efflux transmembrane transporter activity
NRF13_RS19150	COG1136	(ABC) transporter
NRF13_RS19155	COG2205	protein histidine kinase activity
NRF13_RS19160	COG0745	RESPONSE REGULATOR receiver
NRF13_RS19165	COG2205	protein histidine kinase activity
NRF13_RS19170	COG0745	RESPONSE REGULATOR receiver
NRF13_RS19195	COG0745	RESPONSE REGULATOR receiver
NRF13_RS19225	COG1082	Xylose isomerase domain protein TIM barrel
NRF13_RS19235	COG2814	Major facilitator Superfamily
NRF13_RS19265	COG1349	DNA-binding transcription factor activity
NRF13_RS19270	COG0667	Aldo Keto reductase
NRF13_RS19275	COG2814	Major facilitator Superfamily
NRF13_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS19295	COG2197	response regulator
NRF13_RS19300	COG4585	Histidine kinase
NRF13_RS19305	COG3239	Fatty acid desaturase
NRF13_RS19310	COG1309	transcriptional regulator
NRF13_RS19315	COG1012	belongs to the aldehyde dehydrogenase family
NRF13_RS19320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRF13_RS19330	COG0640	Transcriptional regulator
NRF13_RS19335	COG2814	Major facilitator Superfamily
NRF13_RS19340	COG1714	RDD family
NRF13_RS19350	COG0450	alkyl hydroperoxide reductase
NRF13_RS19355	COG3634	alkyl hydroperoxide reductase activity
NRF13_RS19360	COG1113	amino acid transport
NRF13_RS19370	COG2080	2 iron, 2 sulfur cluster binding
NRF13_RS19385	COG2068	MobA-Related Protein
NRF13_RS19390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NRF13_RS19410	COG0270	DNA (cytosine-5-)-methyltransferase activity
NRF13_RS19455	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NRF13_RS19460	COG0667	Aldo Keto reductase
NRF13_RS19465	COG0456	acetyltransferase
NRF13_RS19475	COG0457	Tetratricopeptide repeat
NRF13_RS19480	COG0010	Belongs to the arginase family
NRF13_RS19485	COG0833	amino acid
NRF13_RS19490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRF13_RS19495	COG5658	integral membrane protein
NRF13_RS19500	COG0640	Transcriptional regulator
NRF13_RS19505	COG3829	transcription factor binding
NRF13_RS19515	COG0488	(ABC) transporter
NRF13_RS19530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NRF13_RS19535	COG5002	protein histidine kinase activity
NRF13_RS19545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRF13_RS19550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NRF13_RS19555	COG4853	Protein conserved in bacteria
NRF13_RS19560	COG4863	YycH protein
NRF13_RS19565	COG5002	protein histidine kinase activity
NRF13_RS19570	COG0745	RESPONSE REGULATOR receiver
NRF13_RS19600	COG0346	lactoylglutathione lyase activity
NRF13_RS19605	COG0305	Participates in initiation and elongation during chromosome replication
NRF13_RS19620	COG3093	addiction module antidote protein HigA
NRF13_RS19625	COG0297	glycogen (starch) synthase activity
NRF13_RS19635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NRF13_RS19640	COG0438	transferase activity, transferring glycosyl groups
NRF13_RS19650	COG0515	serine threonine protein kinase
NRF13_RS19660	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NRF13_RS19665	COG4241	membrane
NRF13_RS19675	COG5577	PFAM Coat F domain
NRF13_RS19680	COG1733	regulation of RNA biosynthetic process
NRF13_RS19700	COG0697	spore germination
NRF13_RS19705	COG1621	beta-fructofuranosidase activity
NRF13_RS19710	COG1621	beta-fructofuranosidase activity
NRF13_RS19715	COG1802	Transcriptional regulator
NRF13_RS19720	COG2318	DinB family
NRF13_RS19725	COG2211	Major facilitator Superfamily
NRF13_RS19730	COG0697	spore germination
NRF13_RS19735	COG0583	DNA-binding transcription factor activity
NRF13_RS19745	COG0778	Nitroreductase
NRF13_RS19750	COG1846	Transcriptional regulator
NRF13_RS19755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NRF13_RS19760	COG1846	Transcriptional regulator
NRF13_RS19780	COG0583	DNA-binding transcription factor activity
NRF13_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
NRF13_RS19790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRF13_RS19795	COG0697	spore germination
NRF13_RS19805	COG4978	Transcriptional regulator
NRF13_RS19805	COG0789	Transcriptional regulator
NRF13_RS19810	COG1811	Na channel or pump
NRF13_RS19820	COG1331	Highly conserved protein containing a thioredoxin domain
NRF13_RS19825	COG1266	CAAX protease self-immunity
NRF13_RS19830	COG2814	Major facilitator Superfamily
NRF13_RS19830	COG0477	Major facilitator Superfamily
NRF13_RS19835	COG0346	lactoylglutathione lyase activity
NRF13_RS19840	COG1609	Transcriptional regulator
NRF13_RS19845	COG0708	Exodeoxyribonuclease III
NRF13_RS19850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRF13_RS19855	COG2169	Transcriptional regulator
NRF13_RS19865	COG0629	single-stranded DNA binding
NRF13_RS19875	COG0012	GTP binding
NRF13_RS19880	COG0243	molybdopterin cofactor binding
NRF13_RS19885	COG4481	Protein conserved in bacteria
NRF13_RS19890	COG3949	Membrane
NRF13_RS19905	COG1475	DNA binding
NRF13_RS19910	COG1192	Involved in chromosome partitioning
NRF13_RS19935	COG1847	R3H domain protein
NRF13_RS19940	COG0706	membrane insertase activity