locus-tag class description BVELS4_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BVELS4_RS00015 ENOG410848D S4 domain protein YaaA BVELS4_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BVELS4_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVELS4_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVELS4_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BVELS4_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BVELS4_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BVELS4_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BVELS4_RS00095 ENOG4105BZW Glycerate kinase BVELS4_RS00105 ENOG4105ZMH deoxynucleoside kinase BVELS4_RS00115 ENOG4105VRS hydrolase family 18 BVELS4_RS00120 ENOG4105GTG Isochorismatase BVELS4_RS00125 ENOG4108Z6B deaminase BVELS4_RS00135 ENOG4105C6E dna polymerase iii BVELS4_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BVELS4_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BVELS4_RS00155 ENOG41067KS pro-sigma K processing BVELS4_RS00195 ENOG4105CDW Resistance protein BVELS4_RS00200 ENOG4105CXN decarboxylase BVELS4_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BVELS4_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II BVELS4_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) BVELS4_RS00220 ENOG4105FA2 dna polymerase iii BVELS4_RS00225 ENOG4105MA4 psp1 domain protein BVELS4_RS00235 ENOG41060K3 Methyltransferase BVELS4_RS00240 ENOG4105VC4 domain protein BVELS4_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BVELS4_RS00250 ENOG4105KRN Transcriptional regulator, abrb family BVELS4_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BVELS4_RS00260 ENOG4105F8V Hydrolase, tatD family BVELS4_RS00265 ENOG41069ER domain protein BVELS4_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BVELS4_RS00280 ENOG4105XFA sporulation peptidase YabG BVELS4_RS00285 ENOG4105W42 Veg protein BVELS4_RS00290 ENOG4105XEW small acid-soluble spore protein BVELS4_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BVELS4_RS00300 ENOG4105DFT pur operon repressor BVELS4_RS00305 ENOG4105KME endoribonuclease L-psp BVELS4_RS00310 ENOG4105K4W Could be involved in septation (By similarity) BVELS4_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BVELS4_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BVELS4_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BVELS4_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor BVELS4_RS00345 ENOG4108M14 stage v sporulation protein t BVELS4_RS00355 ENOG4108IY2 MazG family BVELS4_RS00360 ENOG41082I2 s4 domain protein BVELS4_RS00365 ENOG4105VYY sporulation protein yabp BVELS4_RS00380 ENOG41060GV RNA binding s1 domain protein BVELS4_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BVELS4_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase BVELS4_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BVELS4_RS00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BVELS4_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BVELS4_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BVELS4_RS00440 ENOG4105C6T cysteine synthase BVELS4_RS00445 ENOG4105CRQ synthase (Component I) BVELS4_RS00450 ENOG4105DDQ anthranilate synthase BVELS4_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BVELS4_RS00460 ENOG4105EEI dihydropteroate synthase BVELS4_RS00465 ENOG4105KRF dihydroneopterin aldolase BVELS4_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BVELS4_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BVELS4_RS00485 ENOG4105CRK lysyL-tRNA synthetase BVELS4_RS00570 ENOG4108Z0C Uvrb UvrC protein BVELS4_RS00575 ENOG41066A3 ATP guanido phosphotransferase BVELS4_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BVELS4_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BVELS4_RS00595 ENOG4105CTP PilT protein domain protein BVELS4_RS00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BVELS4_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BVELS4_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BVELS4_RS00615 ENOG4105D7W serine acetyltransferase BVELS4_RS00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BVELS4_RS00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 BVELS4_RS00635 ENOG4105M0M Tetracycline resistance protein BVELS4_RS00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BVELS4_RS00670 ENOG4108VZM 50s ribosomal protein L10 BVELS4_RS00680 ENOG4107Y49 methyltransferase BVELS4_RS00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVELS4_RS00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVELS4_RS00695 ENOG4105XPM ribosomal protein BVELS4_RS00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BVELS4_RS00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BVELS4_RS00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BVELS4_RS00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BVELS4_RS00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BVELS4_RS00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BVELS4_RS00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BVELS4_RS00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BVELS4_RS00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BVELS4_RS00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BVELS4_RS00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BVELS4_RS00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BVELS4_RS00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BVELS4_RS00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BVELS4_RS00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BVELS4_RS00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BVELS4_RS00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BVELS4_RS00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BVELS4_RS00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BVELS4_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BVELS4_RS00850 ENOG41067V7 50S ribosomal protein L36 BVELS4_RS00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BVELS4_RS00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BVELS4_RS00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BVELS4_RS00870 ENOG4108ZT0 50S ribosomal protein l17 BVELS4_RS00875 ENOG4108JJB ABC transporter BVELS4_RS00880 ENOG4108JJB ABC transporter BVELS4_RS00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BVELS4_RS00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BVELS4_RS00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BVELS4_RS00900 ENOG4108UJD 30S ribosomal protein S9 BVELS4_RS00905 ENOG4108I0C methyltransferase BVELS4_RS00925 ENOG4105D1F ATP-binding protein BVELS4_RS00940 ENOG4108NMV polysaccharide deacetylase BVELS4_RS01005 ENOG4108JPW Aminotransferase BVELS4_RS01015 ENOG4105CPQ Dehydrogenase BVELS4_RS01020 ENOG4105CHH sulfate transporter BVELS4_RS01030 ENOG4108SA1 esterase BVELS4_RS01050 ENOG410874W AraC family transcriptional regulator BVELS4_RS01055 ENOG4105EHZ conserved protein UCP016719 BVELS4_RS01060 ENOG4105D17 glycoside hydrolase, family 3 domain protein BVELS4_RS01075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BVELS4_RS01085 ENOG4105EWC Purine nucleoside phosphorylase BVELS4_RS01115 ENOG4105EMN RNA polymerase sigma factor BVELS4_RS01125 ENOG4105C8B TIGR00159 family BVELS4_RS01130 ENOG4107U5W ybbr family BVELS4_RS01135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BVELS4_RS01145 ENOG4105CJ1 ABC, transporter BVELS4_RS01160 ENOG4106K80 BVELS4_RS01170 ENOG41067MG lrgb family BVELS4_RS01180 ENOG41061AU MarR family Transcriptional regulator BVELS4_RS01195 ENOG4105BZU Histidine kinase BVELS4_RS01200 ENOG4105WH1 Two component transcriptional regulator luxr family BVELS4_RS01205 ENOG4105CJ1 ABC, transporter BVELS4_RS01230 ENOG4106DDH Sporulation-specific SASP protein BVELS4_RS01245 ENOG4107QTZ amino acid BVELS4_RS01250 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BVELS4_RS01265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BVELS4_RS01270 ENOG4105CXY transporter BVELS4_RS01305 ENOG4107SCQ Iron-containing alcohol dehydrogenase BVELS4_RS01310 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BVELS4_RS01315 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BVELS4_RS01320 ENOG4107ZTW SNARE associated Golgi BVELS4_RS01335 ENOG4105C72 UPF0176 protein BVELS4_RS01345 ENOG4105CM2 brancheD-chain amino acid aminotransferase BVELS4_RS01350 ENOG4108IQI permease BVELS4_RS01355 ENOG4108J5H Homocysteine s-methyltransferase BVELS4_RS01365 ENOG4105CSV Glutaminase BVELS4_RS01395 ENOG41076HS cation diffusion facilitator family transporter BVELS4_RS01400 ENOG4108TVJ Nitroreductase BVELS4_RS01405 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BVELS4_RS01410 ENOG4108VGI doxx family BVELS4_RS01415 ENOG4105XXY Thioredoxin BVELS4_RS01430 ENOG4105DGI Alkaline phosphatase BVELS4_RS01435 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BVELS4_RS01440 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BVELS4_RS01445 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BVELS4_RS01450 ENOG4107EPV Aminotransferase class V BVELS4_RS01455 ENOG4105C0R drug resistance transporter emrb qaca subfamily BVELS4_RS01460 ENOG4105J7D transcriptional regulator BVELS4_RS01465 ENOG4107RB3 L-asparaginase BVELS4_RS01470 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BVELS4_RS01475 ENOG41060AI SEC-C motif BVELS4_RS01480 ENOG4107SET aldo keto reductase BVELS4_RS01510 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BVELS4_RS01520 ENOG4105DSE periplasmic solute binding protein BVELS4_RS01525 ENOG4105DIK (ABC) transporter BVELS4_RS01535 ENOG4105DEN Luciferase family BVELS4_RS01540 ENOG4108N0M stress protein BVELS4_RS01545 ENOG4106FN3 tellurium resistance protein BVELS4_RS01550 ENOG4106FN3 tellurium resistance protein BVELS4_RS01555 ENOG4107TS3 membrane protein, TerC BVELS4_RS01560 ENOG4108TTB tellurium resistance protein BVELS4_RS01570 ENOG41079KZ Major Facilitator Superfamily BVELS4_RS01575 ENOG4108IJ7 Glycine betaine BVELS4_RS01580 ENOG4107SQ8 Glycine betaine BVELS4_RS01610 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BVELS4_RS01640 ENOG4105EIG urea carboxylase-associated protein 1 BVELS4_RS01655 ENOG4105I1F Resistance protein BVELS4_RS01660 ENOG4108WBH protein TIM barrel BVELS4_RS01665 ENOG4105DJB Major Facilitator Superfamily BVELS4_RS01670 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BVELS4_RS01675 ENOG4105I82 acetyl xylan esterase BVELS4_RS01680 ENOG410756H nucleotidyltransferase BVELS4_RS01690 ENOG4105C26 Dehydrogenase BVELS4_RS01695 ENOG4105CK7 Sodium proline symporter BVELS4_RS01700 ENOG4107YHD transcriptional regulator BVELS4_RS01705 ENOG4105CAY ferredoxin--nadp reductase BVELS4_RS01710 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BVELS4_RS01715 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BVELS4_RS01720 ENOG4108IFG nitrite reductase, (NAD(P)H) BVELS4_RS01725 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BVELS4_RS01740 ENOG4105CKI cobalamin synthesis protein BVELS4_RS01745 ENOG4105E2A Dehydrogenase BVELS4_RS01750 ENOG4105HHM rdd domain containing protein BVELS4_RS01760 ENOG4105CS2 ec 3.2.1.21 BVELS4_RS01775 ENOG41080HJ 6-phospho 3-hexuloisomerase BVELS4_RS01780 ENOG4108VA3 3-hexulose-6-phosphate synthase BVELS4_RS01785 ENOG4105KVH Transcriptional regulator BVELS4_RS01790 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS01810 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BVELS4_RS01820 ENOG4105SX7 Transporter BVELS4_RS01840 ENOG4105CDA abc transporter atp-binding protein BVELS4_RS01845 ENOG4105DRP amino acid AbC transporter BVELS4_RS01855 ENOG4106P55 Transcriptional regulator BVELS4_RS01860 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BVELS4_RS01865 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BVELS4_RS01870 ENOG41069ZX BVELS4_RS01875 ENOG41069ZX BVELS4_RS01880 ENOG4105DUX Transporter BVELS4_RS01895 ENOG4105E1K spore germination protein BVELS4_RS01920 ENOG4105EAB amino acid AbC transporter BVELS4_RS01925 ENOG4108HW4 amino acid AbC transporter BVELS4_RS01940 ENOG4108PGP mmge prpd family protein BVELS4_RS01950 ENOG4107WD8 ABC transporter, permease BVELS4_RS01955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS01960 ENOG4105BZU Histidine kinase BVELS4_RS01980 ENOG4105CFH Aspartokinase BVELS4_RS01985 ENOG4105DHS permease protein BVELS4_RS01990 ENOG4105CM4 permease protein BVELS4_RS01995 ENOG4108IPW abc transporter atp-binding protein BVELS4_RS02010 ENOG4105R8C Transcriptional regulator BVELS4_RS02015 ENOG4108DBC nitroreductase BVELS4_RS02020 ENOG41067V3 Antibiotic biosynthesis monooxygenase BVELS4_RS02025 ENOG4105YVS arsR family transcriptional regulator BVELS4_RS02035 ENOG4108JPW Aminotransferase BVELS4_RS02040 ENOG4105C26 Dehydrogenase BVELS4_RS02050 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BVELS4_RS02055 ENOG4105KTB nuclear export factor GLE1 BVELS4_RS02060 ENOG4108T5E Copper resistance protein BVELS4_RS02065 ENOG4108ZYE Transcriptional regulator BVELS4_RS02085 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BVELS4_RS02105 ENOG4105E7W lamb ycsf family protein BVELS4_RS02110 ENOG4105C5A transporter BVELS4_RS02115 ENOG4105CFM UPF0317 protein BVELS4_RS02120 ENOG4105P4J Allophanate hydrolase, subunit 1 BVELS4_RS02130 ENOG4107258 Transcriptional regulator BVELS4_RS02135 ENOG4105XJB lipolytic protein G-D-S-L family BVELS4_RS02145 ENOG41061CK Antibiotic biosynthesis monooxygenase BVELS4_RS02150 ENOG4107RVG penicillin-binding protein BVELS4_RS02155 ENOG4107QM2 Aldo Keto reductase BVELS4_RS02160 ENOG4105ETD TRANSCRIPTIONal BVELS4_RS02170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BVELS4_RS02185 ENOG410606W general stress protein BVELS4_RS02195 ENOG4105VCH membrane BVELS4_RS02205 ENOG4105C9U ATP-dependent DNA helicase RecQ BVELS4_RS02220 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BVELS4_RS02225 ENOG4107R8N Glycosyl transferase, family 2 BVELS4_RS02235 ENOG4105C0X amino acid BVELS4_RS02270 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BVELS4_RS02280 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BVELS4_RS02285 ENOG4105RXJ BVELS4_RS02290 ENOG4105KPY Small multidrug resistance protein BVELS4_RS02295 ENOG4105EU9 BVELS4_RS02300 ENOG4105QVS general stress protein BVELS4_RS02305 ENOG41082W1 Cupin 2, conserved barrel domain protein BVELS4_RS02320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BVELS4_RS02325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BVELS4_RS02330 ENOG4108MRH transcriptional regulatory protein BVELS4_RS02335 ENOG4107QJT sodium dicarboxylate symporter BVELS4_RS02340 ENOG4106F5Q Membrane BVELS4_RS02345 ENOG4105CJ1 ABC, transporter BVELS4_RS02360 ENOG4105FDT acyl-CoA dehydrogenase BVELS4_RS02380 ENOG4105SZ6 Thioredoxin BVELS4_RS02385 ENOG4105CPF Cell wall formation (By similarity) BVELS4_RS02390 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BVELS4_RS02395 ENOG4105C1J atp-dependent rna helicase BVELS4_RS02400 ENOG410905X membrane-flanked domain protein BVELS4_RS02405 ENOG4105CKV Membrane BVELS4_RS02415 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BVELS4_RS02420 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BVELS4_RS02425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BVELS4_RS02435 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BVELS4_RS02440 ENOG4107MMM Anti-sigma-factor antagonist BVELS4_RS02445 ENOG4105FUA antagonist BVELS4_RS02450 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BVELS4_RS02455 ENOG4107SGM protein serine threonine phosphatase BVELS4_RS02460 ENOG4105WN5 stage II sporulation protein BVELS4_RS02465 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BVELS4_RS02475 ENOG41064BQ Phosphatase BVELS4_RS02490 ENOG410906U SprT-like BVELS4_RS02530 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BVELS4_RS02535 ENOG41068WC Domain of unknown function (DUF955) BVELS4_RS02540 ENOG4108IMY Transcriptional regulator BVELS4_RS02565 ENOG4108RYM conjugative transposon protein BVELS4_RS02570 ENOG4106BHR ftsk SpoIIIE family protein BVELS4_RS02575 ENOG4106128 DNA-binding helix-turn-helix protein BVELS4_RS02625 ENOG4105P1M Domain of unknown function (DUF1874) BVELS4_RS02635 ENOG4105K4H Nlp p60 protein BVELS4_RS02675 ENOG41080TC multidrug resistance protein BVELS4_RS02745 ENOG4106ANW SMI1_KNR4 BVELS4_RS02750 ENOG4106BHF BVELS4_RS02755 ENOG4105VFE sira family BVELS4_RS02765 ENOG4105DXI Major Facilitator superfamily BVELS4_RS02775 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BVELS4_RS02785 ENOG4105C94 Transporter BVELS4_RS02790 ENOG4105CSH Transporter BVELS4_RS02795 ENOG4105K56 Transcriptional regulator BVELS4_RS02805 ENOG4108ZMQ domain protein BVELS4_RS02820 ENOG4108Z40 Transcriptional regulator BVELS4_RS02825 ENOG4108RYK Nad-dependent epimerase dehydratase BVELS4_RS02830 ENOG4105M4P Tetr family transcriptional regulator BVELS4_RS02835 ENOG4105E1F short-chain dehydrogenase reductase BVELS4_RS02840 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BVELS4_RS02845 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BVELS4_RS02855 ENOG4105ECK Fatty Acid Desaturase BVELS4_RS02865 ENOG4105VEQ Cold shock protein BVELS4_RS02870 ENOG4108VJ1 Transcriptional regulator (CarD family BVELS4_RS02875 ENOG4105XTG Pfam:DUF156 BVELS4_RS02880 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BVELS4_RS02890 ENOG4105VFE sira family BVELS4_RS02895 ENOG4107TPS domain protein BVELS4_RS02900 ENOG4105VFE sira family BVELS4_RS02905 ENOG41087NI Sulfite exporter TauE/SafE BVELS4_RS02925 ENOG4105IRW patatin-like phospholipase family protein BVELS4_RS02935 ENOG41082W1 Cupin 2, conserved barrel domain protein BVELS4_RS02950 ENOG4105DNP FAD linked oxidase domain protein BVELS4_RS02960 ENOG4105PGM cation diffusion facilitator family transporter BVELS4_RS02965 ENOG4105H3G oxidoreductase BVELS4_RS02975 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BVELS4_RS02985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BVELS4_RS03010 ENOG4105DQ4 alcohol dehydrogenase BVELS4_RS03015 ENOG4105VUF Transcriptional regulator BVELS4_RS03025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BVELS4_RS03060 ENOG4105EQ0 Major Facilitator superfamily BVELS4_RS03065 ENOG4108JGH Tetr family transcriptional regulator BVELS4_RS03070 ENOG4105T38 integral membrane protein BVELS4_RS03075 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BVELS4_RS03090 ENOG4105E2A Dehydrogenase BVELS4_RS03095 ENOG4105PGS Spore coat protein BVELS4_RS03105 ENOG4106UW1 Major Facilitator superfamily BVELS4_RS03115 ENOG4108UW5 maltose o-acetyltransferase BVELS4_RS03120 ENOG4105ENE Histidine kinase BVELS4_RS03125 ENOG4108VB1 regulatoR BVELS4_RS03130 ENOG4105EYF MMPL domain protein BVELS4_RS03140 ENOG4105C57 major facilitator superfamily BVELS4_RS03145 ENOG41062ES Transcriptional regulator BVELS4_RS03160 ENOG4108JYZ YitT family BVELS4_RS03170 ENOG4105C2C drug resistance transporter, Bcr CflA BVELS4_RS03175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BVELS4_RS03195 ENOG41090E6 transcriptional regulator MERR family BVELS4_RS03210 ENOG4105F2W methyltransferase BVELS4_RS03215 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BVELS4_RS03220 ENOG4105DRR Transcriptional regulator, GntR family BVELS4_RS03240 ENOG4105FQP Beta-lactamase BVELS4_RS03250 ENOG41090UD (LipO)protein BVELS4_RS03255 ENOG4108SUT Major Facilitator Superfamily BVELS4_RS03260 ENOG4108TZY GntR Family Transcriptional Regulator BVELS4_RS03265 ENOG4105JXH GntR family transcriptional regulator BVELS4_RS03270 ENOG4105DJ2 Major Facilitator Superfamily BVELS4_RS03290 ENOG4107QTZ amino acid BVELS4_RS03310 ENOG4107QNK )-transporter BVELS4_RS03350 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BVELS4_RS03355 ENOG4105K8N protein family UPF0079, ATPase BVELS4_RS03360 ENOG41072GX Peptidase M22 Glycoprotease BVELS4_RS03365 ENOG410801F ribosomal-protein-alanine acetyltransferase BVELS4_RS03370 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BVELS4_RS03375 ENOG4105C5H ABC transporter BVELS4_RS03380 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BVELS4_RS03385 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BVELS4_RS03390 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BVELS4_RS03395 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BVELS4_RS03405 ENOG4108TYN CAAX amino terminal protease family protein BVELS4_RS03415 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BVELS4_RS03435 ENOG4105PGZ NB-ARC domain BVELS4_RS03440 ENOG4105CPQ Dehydrogenase BVELS4_RS03445 ENOG4105CT4 transporter BVELS4_RS03460 ENOG41087YS Phage shock protein A BVELS4_RS03465 ENOG4105DQX Zinc finger domain BVELS4_RS03470 ENOG4108WV1 Pfam:DUF477 BVELS4_RS03480 ENOG4105EXC Acyl-transferase BVELS4_RS03485 ENOG4108P49 AntiSigma factor BVELS4_RS03490 ENOG4105JVQ RNA Polymerase BVELS4_RS03520 ENOG4107STQ Multicopper oxidase BVELS4_RS03525 ENOG4105C85 amino acid BVELS4_RS03535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BVELS4_RS03550 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BVELS4_RS03565 ENOG4105C7N Xanthine uracil vitamin C permease BVELS4_RS03590 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BVELS4_RS03595 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BVELS4_RS03600 ENOG4105C83 adenylosuccinate lyase BVELS4_RS03605 ENOG4105C8V SAICAR synthetase BVELS4_RS03610 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BVELS4_RS03615 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BVELS4_RS03620 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BVELS4_RS03630 ENOG4105CXB phosphoribosylaminoimidazole synthetase BVELS4_RS03635 ENOG4108V3E phosphoribosylglycinamide formyltransferase BVELS4_RS03640 ENOG4105DC1 bifunctional purine biosynthesis protein purh BVELS4_RS03645 ENOG4105C12 Phosphoribosylglycinamide synthetase BVELS4_RS03665 ENOG4105KGF protein, YerC YecD BVELS4_RS03670 ENOG4105CBC glutamate synthase BVELS4_RS03680 ENOG4105C4R Atp-dependent dna helicase BVELS4_RS03685 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BVELS4_RS03695 ENOG4105CRN Aminoglycoside phosphotransferase BVELS4_RS03700 ENOG4105KT7 mgtC SapB transporter BVELS4_RS03705 ENOG4105CK7 Sodium proline symporter BVELS4_RS03710 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BVELS4_RS03715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BVELS4_RS03720 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BVELS4_RS03725 ENOG4108IG5 Transcriptional regulator BVELS4_RS03735 ENOG4105CBD Diacylglycerol kinase BVELS4_RS03740 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BVELS4_RS03745 ENOG4105CVR type I restriction-modification system BVELS4_RS03750 ENOG4107XZC Restriction modification system DNA (Specificity BVELS4_RS03755 ENOG4105DZR Type I site-specific deoxyribonuclease BVELS4_RS03785 ENOG4106BHF BVELS4_RS03790 ENOG4105CDY transcriptional regulatory protein BVELS4_RS03810 ENOG4105WEF catalase BVELS4_RS03815 ENOG4105M18 -acetyltransferase BVELS4_RS03825 ENOG4105H67 Protein of unknown function (DUF421) BVELS4_RS03835 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BVELS4_RS03840 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BVELS4_RS03860 ENOG4106I4J membrane BVELS4_RS03870 ENOG41082F9 transcriptional regulator BVELS4_RS03875 ENOG41061H0 Monooxygenase BVELS4_RS03880 ENOG4108R1P BVELS4_RS03885 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BVELS4_RS03900 ENOG4105CJ1 ABC, transporter BVELS4_RS03950 ENOG4105E0M Sulfatase BVELS4_RS03955 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BVELS4_RS03965 ENOG41090R9 glycosyltransferase BVELS4_RS03970 ENOG4107R51 Glycosyl transferase, family 2 BVELS4_RS03975 ENOG41090R9 glycosyltransferase BVELS4_RS03980 ENOG4105EU0 Major facilitator Superfamily BVELS4_RS03985 ENOG4105CUB amino acid BVELS4_RS03990 ENOG4105C26 Dehydrogenase BVELS4_RS03995 ENOG4105FKZ Methyl-accepting chemotaxis BVELS4_RS04000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BVELS4_RS04005 ENOG4107TVC Glycosyl transferase, family 2 BVELS4_RS04010 ENOG4105C5H ABC transporter BVELS4_RS04015 ENOG4107SWG transcriptional regulator MERR family BVELS4_RS04020 ENOG4105DXB Major Facilitator superfamily BVELS4_RS04025 ENOG4105C5H ABC transporter BVELS4_RS04030 ENOG4105FDU atp-dependent rna helicase BVELS4_RS04040 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BVELS4_RS04055 ENOG4108J20 pectate lyase BVELS4_RS04060 ENOG4107QPK )-transporter BVELS4_RS04085 ENOG4108VAC response regulator BVELS4_RS04095 ENOG4108Z6X (sortase) family BVELS4_RS04105 ENOG4108MRH transcriptional regulatory protein BVELS4_RS04130 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BVELS4_RS04135 ENOG4108RPX mosc domain containing protein BVELS4_RS04155 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BVELS4_RS04195 ENOG4105C5Y PTS System BVELS4_RS04200 ENOG4105CG3 alpha amylase, catalytic region BVELS4_RS04205 ENOG4107414 GntR family transcriptional regulator BVELS4_RS04210 ENOG4108RCM Nitroreductase BVELS4_RS04225 ENOG4105CGH 5'-nucleotidase BVELS4_RS04230 ENOG4107RKG DJ-1/PfpI family BVELS4_RS04235 ENOG4105ETE Transcriptional regulator (LacI family BVELS4_RS04245 ENOG4105FF2 Type I DHQase BVELS4_RS04260 ENOG4105KJF protein tyrosine phosphatase BVELS4_RS04270 ENOG4107U9T Pfam:Ribonuclease_BN BVELS4_RS04275 ENOG4108ISG Major Facilitator BVELS4_RS04280 ENOG4105UPD Calcium Proton BVELS4_RS04290 ENOG4105D8X mechanosensitive ion channel BVELS4_RS04310 ENOG4106KE4 Dehydrogenase BVELS4_RS04320 ENOG4105D7N magnesium and cobalt transport protein CorA BVELS4_RS04330 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BVELS4_RS04350 ENOG4107RUY (E1 component), alpha subunit BVELS4_RS04360 ENOG4107QKR Dehydrogenase BVELS4_RS04370 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BVELS4_RS04380 ENOG4105F8D glycoside hydrolase family 4 BVELS4_RS04385 ENOG4108Q3X Transcriptional regulator BVELS4_RS04390 ENOG4105CI1 PTS System BVELS4_RS04400 ENOG4105BZ1 (ABC) transporter BVELS4_RS04405 ENOG4105BZ1 (ABC) transporter BVELS4_RS04415 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BVELS4_RS04420 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BVELS4_RS04425 ENOG4105U3E Transcriptional regulator BVELS4_RS04430 ENOG4105DYS nad(p)h dehydrogenase (quinone) BVELS4_RS04435 ENOG4105H93 Acyltransferase family BVELS4_RS04450 ENOG4108YYS metal-dependent hydrolase (By similarity) BVELS4_RS04455 ENOG4105C0R drug resistance transporter emrb qaca subfamily BVELS4_RS04460 ENOG410834F Transcriptional regulator BVELS4_RS04470 ENOG4105JAB phenazine biosynthesis protein, phzf family BVELS4_RS04475 ENOG4107Y03 Nitroreductase BVELS4_RS04490 ENOG4105ECP epimerase BVELS4_RS04495 ENOG410902V Modulates RecA activity (By similarity) BVELS4_RS04505 ENOG4105F27 Major Facilitator BVELS4_RS04515 ENOG4108TCS Glutamyl endopeptidase BVELS4_RS04535 ENOG4106AKJ BVELS4_RS04540 ENOG4105D74 hydrolase BVELS4_RS04545 ENOG4105CKK Glycosyl transferase, family 2 BVELS4_RS04550 ENOG4105EJV Membrane BVELS4_RS04555 ENOG41067AE Membrane-bound metal-dependent hydrolase BVELS4_RS04560 ENOG4105CEN a g-specific adenine glycosylase BVELS4_RS04565 ENOG4106BXE BVELS4_RS04570 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BVELS4_RS04590 ENOG4105BZ1 (ABC) transporter BVELS4_RS04595 ENOG4107NBY Membrane BVELS4_RS04600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BVELS4_RS04605 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BVELS4_RS04610 ENOG4105G5W regulator Fur family BVELS4_RS04615 ENOG4105TUA UPF0295 protein BVELS4_RS04720 ENOG4107S6Z Na H antiporter BVELS4_RS04725 ENOG4105EC3 peptidase S51, dipeptidase E BVELS4_RS04730 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BVELS4_RS04735 ENOG4105DNP FAD linked oxidase domain protein BVELS4_RS04745 ENOG4105DEF Extracellular solute-binding protein, family 5 BVELS4_RS04755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BVELS4_RS04760 ENOG4105C3U ABC transporter BVELS4_RS04765 ENOG4108JQ7 (ABC) transporter BVELS4_RS04780 ENOG4105E2Y ABC, transporter BVELS4_RS04785 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BVELS4_RS04790 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BVELS4_RS04800 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BVELS4_RS04805 ENOG4107D63 BVELS4_RS04810 ENOG4105VZ8 Transcriptional regulator BVELS4_RS04825 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BVELS4_RS04835 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BVELS4_RS04855 ENOG4105CYN Serine protein kinase BVELS4_RS04865 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BVELS4_RS04870 ENOG4105CW7 secretion protein, HlyD family BVELS4_RS04875 ENOG4105C0R drug resistance transporter emrb qaca subfamily BVELS4_RS04880 ENOG4105CS1 NAD(P)H quinone oxidoreductase BVELS4_RS04895 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BVELS4_RS04900 ENOG4105CZV ABC transporter BVELS4_RS04905 ENOG4105CJ1 ABC, transporter BVELS4_RS04910 ENOG4108TU7 Inherit from COG: (ABC) transporter BVELS4_RS04915 ENOG4105VEQ Cold shock protein BVELS4_RS04925 ENOG4105BZU Histidine kinase BVELS4_RS04965 ENOG4108YBP pseudouridine synthase BVELS4_RS04975 ENOG41080XP Cbs domain BVELS4_RS04980 ENOG4107YBY Hydrolase BVELS4_RS04985 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BVELS4_RS04990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BVELS4_RS04995 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BVELS4_RS05005 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BVELS4_RS05010 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BVELS4_RS05020 ENOG4105BZU Histidine kinase BVELS4_RS05025 ENOG4105WH1 Two component transcriptional regulator luxr family BVELS4_RS05060 ENOG4105ED1 spovr family BVELS4_RS05065 ENOG4105G6Z alkaline phosphatase BVELS4_RS05080 ENOG4105BZN citrate synthase BVELS4_RS05085 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BVELS4_RS05090 ENOG4105CUB amino acid BVELS4_RS05095 ENOG4105C8J )-transporter BVELS4_RS05105 ENOG4105J37 BVELS4_RS05110 ENOG4108AEY RNA polymerase sigma factor BVELS4_RS05115 ENOG4105F6E Acyl-transferase BVELS4_RS05120 ENOG4105C37 (CBS) domain BVELS4_RS05130 ENOG4105CHM Aminotransferase BVELS4_RS05135 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BVELS4_RS05140 ENOG4105C37 (CBS) domain BVELS4_RS05150 ENOG4105WMR Protein CrcB homolog BVELS4_RS05155 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BVELS4_RS05165 ENOG4105D64 Mechanosensitive ion channel BVELS4_RS05170 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BVELS4_RS05175 ENOG4107VMI polysaccharide deacetylase BVELS4_RS05180 ENOG4105F0I Aminotransferase BVELS4_RS05185 ENOG4105W1N transcriptional regulator BVELS4_RS05190 ENOG4105IIP Membrane BVELS4_RS05200 ENOG4105BZ1 (ABC) transporter BVELS4_RS05205 ENOG4105BZ1 (ABC) transporter BVELS4_RS05225 ENOG410839P BVELS4_RS05235 ENOG4106MP8 UPF0754 membrane protein BVELS4_RS05240 ENOG4105WZB UPF0342 protein BVELS4_RS05245 ENOG4105F1N DNA alkylation repair BVELS4_RS05255 ENOG4105D4P Coproporphyrinogen iii oxidase BVELS4_RS05265 ENOG4107S91 Sodium hydrogen exchanger BVELS4_RS05270 ENOG4105NCW Trka-c domain protein BVELS4_RS05280 ENOG4105CGU Enoyl-CoA hydratase BVELS4_RS05290 ENOG4108IUX (ABC) transporter BVELS4_RS05295 ENOG4105RHA ABC transporter, permease BVELS4_RS05300 ENOG4107VRP DNA repair exonuclease BVELS4_RS05305 ENOG4106D4I domain protein BVELS4_RS05310 ENOG4105EQI Metal Dependent Phosphohydrolase BVELS4_RS05320 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BVELS4_RS05365 ENOG4105NBU tryptophan transport protein BVELS4_RS05370 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BVELS4_RS05375 ENOG4105K59 histidine triad (HIT) protein BVELS4_RS05405 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BVELS4_RS05410 ENOG4105BZ4 penicillin-binding protein BVELS4_RS05415 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BVELS4_RS05420 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BVELS4_RS05425 ENOG4105C1Q protoporphyrinogen oxidase BVELS4_RS05435 ENOG4105ECB domain protein BVELS4_RS05450 ENOG4105DER m42 family BVELS4_RS05460 ENOG4106AXD BVELS4_RS05465 ENOG4108RQ5 Beta-lactamase domain-containing protein BVELS4_RS05470 ENOG4105DF9 Lipoate-protein, ligase BVELS4_RS05480 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS05490 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BVELS4_RS05505 ENOG4108HUF Transporter BVELS4_RS05510 ENOG4107TB6 phosphoglycerate mutase BVELS4_RS05520 ENOG4107F3J Amp-dependent synthetase and ligase BVELS4_RS05525 ENOG4107ZYJ bioY protein BVELS4_RS05530 ENOG4106YBV Methyl-accepting chemotaxis BVELS4_RS05550 ENOG4105XVF Competence transcription factor BVELS4_RS05570 ENOG4108ZMX Domain of unknown function (DU1801) BVELS4_RS05585 ENOG4105X3H Excalibur domain protein BVELS4_RS05590 ENOG4105K8R UPF0145 protein BVELS4_RS05595 ENOG4105E1V na solute symporter BVELS4_RS05600 ENOG4106CAD Protein of unknown function (DUF3311) BVELS4_RS05605 ENOG41060YP BVELS4_RS05620 ENOG4107SCK Monooxygenase BVELS4_RS05625 ENOG4108INS Transcriptional regulator BVELS4_RS05630 ENOG4108KK1 membrane protein AbrB duplication BVELS4_RS05640 ENOG4108IG5 Transcriptional regulator BVELS4_RS05650 ENOG4108QY0 Membrane BVELS4_RS05655 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BVELS4_RS05660 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BVELS4_RS05670 ENOG4105EYH Exonuclease BVELS4_RS05715 ENOG4105ERH Fumarylacetoacetate hydrolase BVELS4_RS05730 ENOG4105CAQ asparagine synthetase BVELS4_RS05740 ENOG4105UQX Mate efflux family protein BVELS4_RS05745 ENOG4106HBX Transcriptional Regulator AraC Family BVELS4_RS05750 ENOG4105SF0 DinB family BVELS4_RS05760 ENOG4105MA6 gCN5-related N-acetyltransferase BVELS4_RS05770 ENOG4108VPT UPF0234 protein BVELS4_RS05775 ENOG4105QNR S1 RNA binding domain protein BVELS4_RS05780 ENOG4105DIH basic membrane BVELS4_RS05785 ENOG4105C8Q Methyl-accepting chemotaxis BVELS4_RS05790 ENOG4107E6A Cytochrome p-450 BVELS4_RS05800 ENOG4105EPR degv family BVELS4_RS05805 ENOG4107AYK membrAne BVELS4_RS05815 ENOG41073B9 BVELS4_RS05825 ENOG4108KP7 hydrolase BVELS4_RS05830 ENOG4108MXZ Esterase BVELS4_RS05835 ENOG4105VG1 fes assembly suf system protein BVELS4_RS05840 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BVELS4_RS05845 ENOG4105IQ5 FAD linked oxidase domain protein BVELS4_RS05855 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BVELS4_RS05860 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BVELS4_RS05865 ENOG4105CAS nag kinase BVELS4_RS05870 ENOG4105C8Y Acetylornithine aminotransferase BVELS4_RS05875 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BVELS4_RS05885 ENOG4105DBV ornithine carbamoyltransferase BVELS4_RS05910 ENOG4107RMD Basic membrane lipoprotein BVELS4_RS05925 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BVELS4_RS05930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BVELS4_RS05940 ENOG4105C3U ABC transporter BVELS4_RS05945 ENOG4108JQ7 (ABC) transporter BVELS4_RS05960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BVELS4_RS05970 ENOG4105C31 Tryptophanyl-tRNA synthetase BVELS4_RS05975 ENOG4108J59 Extracellular solute-binding protein, family 5 BVELS4_RS05980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BVELS4_RS05985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BVELS4_RS05995 ENOG4108JQ7 (ABC) transporter BVELS4_RS06010 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BVELS4_RS06015 ENOG4108ZCF integral membrane protein BVELS4_RS06020 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BVELS4_RS06030 ENOG4105DPN Oligoendopeptidase f BVELS4_RS06040 ENOG4105T58 Dithiol-disulfide isomerase BVELS4_RS06045 ENOG4108Z18 K06886 hemoglobin BVELS4_RS06050 ENOG4105E4C Lytic transglycosylase catalytic BVELS4_RS06055 ENOG4105MIX Adenylate cyclase BVELS4_RS06070 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BVELS4_RS06075 ENOG4105EMS pseudouridine synthase BVELS4_RS06080 ENOG4107S1Q Phosphatase BVELS4_RS06090 ENOG4105ETU transcriptional activator (TenA BVELS4_RS06095 ENOG4108VEU Thiamine monophosphate synthase BVELS4_RS06115 ENOG4105D06 uba thif-type nad fad binding protein BVELS4_RS06120 ENOG4105DWF phosphomethylpyrimidine kinase BVELS4_RS06125 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BVELS4_RS06130 ENOG4107A88 BVELS4_RS06180 ENOG4105ENA helicase BVELS4_RS06200 ENOG4105CJ1 ABC, transporter BVELS4_RS06215 ENOG4108ZMI UPF0477 protein BVELS4_RS06225 ENOG4105C28 cystathionine BVELS4_RS06230 ENOG4105C28 cystathionine BVELS4_RS06245 ENOG4106BHF BVELS4_RS06270 ENOG4106BHF BVELS4_RS06280 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BVELS4_RS06310 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BVELS4_RS06315 ENOG4105CMR udp-glucose 4-epimerase BVELS4_RS06320 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BVELS4_RS06325 ENOG4105CK1 PTS System BVELS4_RS06330 ENOG4105VCP PTS System BVELS4_RS06360 ENOG4105KT7 mgtC SapB transporter BVELS4_RS06385 ENOG4108IEG Formate dehydrogenase Alpha subunit BVELS4_RS06395 ENOG4106A3M Cytochrome p-450 BVELS4_RS06400 ENOG41087PP glycosyltransferase MGT family BVELS4_RS06410 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BVELS4_RS06415 ENOG4105C4B ABC transporter, permease BVELS4_RS06420 ENOG4108IXI (ABC) transporter BVELS4_RS06430 ENOG4105Q95 Cupin 2, conserved barrel domain protein BVELS4_RS06445 ENOG4105D2H Uronic isomerase BVELS4_RS06450 ENOG4105CT4 transporter BVELS4_RS06455 ENOG4107KJX Transcriptional regulator BVELS4_RS06460 ENOG4107QZW Altronate oxidoreductase BVELS4_RS06465 ENOG4105CTX dehydratase BVELS4_RS06470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS06475 ENOG4105F3H Histidine kinase BVELS4_RS06495 ENOG4107TSN permease BVELS4_RS06515 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BVELS4_RS06520 ENOG4105KWG Pfam:DUF1696 BVELS4_RS06525 ENOG4105K7W phage-related replication protein BVELS4_RS06530 ENOG410635T phage-like element pbsx protein BVELS4_RS06575 ENOG4108TFU terminase (Small subunit) BVELS4_RS06580 ENOG4105IG6 Phage terminase, large subunit BVELS4_RS06585 ENOG4108MDF Phage Portal Protein BVELS4_RS06610 ENOG41060SN BVELS4_RS06625 ENOG4105PQS phage protein BVELS4_RS06630 ENOG4105FR7 XkdM protein, phage-like element PBSX BVELS4_RS06635 ENOG4105MTC XkdN-like protein BVELS4_RS06645 ENOG4108FKH Transglycosylase SLT domain BVELS4_RS06645 ENOG4108FKH Transglycosylase SLT domain BVELS4_RS06645 ENOG4108FKH Transglycosylase SLT domain BVELS4_RS06650 ENOG4108WZM domain protein BVELS4_RS06655 ENOG4105X7F BVELS4_RS06665 ENOG4105MFU Protein of unknown function (DUF2634) BVELS4_RS06670 ENOG41066EA baseplate J family protein BVELS4_RS06675 ENOG410906S phage-like element pbsx protein xkdt BVELS4_RS06685 ENOG41068G1 BVELS4_RS06715 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BVELS4_RS06730 ENOG4105CJ3 phosphate transporter BVELS4_RS06735 ENOG4107GRR phosphate transport regulator BVELS4_RS06740 ENOG4107R7I amino acid BVELS4_RS06750 ENOG4105EDW glycosyl transferase, family 39 BVELS4_RS06755 ENOG4105CKK Glycosyl transferase, family 2 BVELS4_RS06765 ENOG4105C0H protease BVELS4_RS06775 ENOG4108ME1 Peptidase M55 D-aminopeptidase BVELS4_RS06780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BVELS4_RS06785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BVELS4_RS06790 ENOG4105C3U ABC transporter BVELS4_RS06800 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BVELS4_RS06805 ENOG4105DTQ mandelate racemase muconate lactonizing BVELS4_RS06810 ENOG4107SN7 NLP P60 protein BVELS4_RS06815 ENOG4108JQ7 (ABC) transporter BVELS4_RS06820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BVELS4_RS06825 ENOG4107TUM Amidinotransferase BVELS4_RS06830 ENOG4108S4H thioesterase Superfamily protein BVELS4_RS06835 ENOG4108428 Inherit from COG: -acetyltransferase BVELS4_RS06845 ENOG41080TC multidrug resistance protein BVELS4_RS06850 ENOG4105CIY formyltetrahydrofolate deformylase BVELS4_RS06855 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BVELS4_RS06870 ENOG4105K56 Transcriptional regulator BVELS4_RS06875 ENOG4108ZHJ Organic hydroperoxide resistance protein BVELS4_RS06890 ENOG4107TVC Glycosyl transferase, family 2 BVELS4_RS06900 ENOG4105D8G Major Facilitator superfamily BVELS4_RS06905 ENOG4108Y4K DNA-binding transcriptional activator BVELS4_RS06915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BVELS4_RS06925 ENOG4108W7F transporter, permease BVELS4_RS06930 ENOG4108JJB ABC transporter BVELS4_RS06935 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BVELS4_RS06940 ENOG4105VRS hydrolase family 18 BVELS4_RS06955 ENOG4105CJW magnesium transporter BVELS4_RS06965 ENOG4105V75 Transcriptional regulator BVELS4_RS06990 ENOG4105DQE DNA ligase BVELS4_RS06995 ENOG4105FDF Could be involved in DNA repair (By similarity) BVELS4_RS07000 ENOG4107T5V SNARE associated Golgi BVELS4_RS07005 ENOG4107TS3 membrane protein, TerC BVELS4_RS07010 ENOG4108WZW RNA polymerase sigma BVELS4_RS07020 ENOG410681C small acid-soluble spore protein BVELS4_RS07030 ENOG4105D0M Protease HtpX homolog BVELS4_RS07045 ENOG410900G Protein of unknown function (DUF421) BVELS4_RS07055 ENOG4108TGC Acyltransferase BVELS4_RS07060 ENOG4105BZU Histidine kinase BVELS4_RS07065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BVELS4_RS07070 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BVELS4_RS07080 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BVELS4_RS07090 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BVELS4_RS07095 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BVELS4_RS07100 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BVELS4_RS07105 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BVELS4_RS07115 ENOG4105BZU Histidine kinase BVELS4_RS07120 ENOG41090MY MarR family Transcriptional regulator BVELS4_RS07125 ENOG4105ER2 Ompa motb domain protein BVELS4_RS07130 ENOG4105E14 MotA TolQ exbB proton channel BVELS4_RS07140 ENOG4108K88 Membrane BVELS4_RS07150 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BVELS4_RS07155 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BVELS4_RS07160 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BVELS4_RS07165 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BVELS4_RS07180 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BVELS4_RS07190 ENOG4105FEA Spore maturation protein BVELS4_RS07220 ENOG4105F0V Cell wall hydrolase BVELS4_RS07235 ENOG4105C59 p-type ATPase BVELS4_RS07240 ENOG4105DC7 peptidase M24 BVELS4_RS07250 ENOG4105CID antiterminator BVELS4_RS07260 ENOG4105KRI phosphocarrier protein (HPr BVELS4_RS07265 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BVELS4_RS07275 ENOG4105F6S Spore photoproduct lyase BVELS4_RS07280 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BVELS4_RS07285 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BVELS4_RS07300 ENOG4105K4I Scp-like extracellular BVELS4_RS07310 ENOG4105BZU Histidine kinase BVELS4_RS07315 ENOG4105CHM Aminotransferase BVELS4_RS07325 ENOG4107R88 Chemotaxis protein (CheV) BVELS4_RS07330 ENOG4105UIN BVELS4_RS07340 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BVELS4_RS07350 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BVELS4_RS07360 ENOG4105EPM Diguanylate phosphodiesterase BVELS4_RS07365 ENOG4107IN1 Protein of unknown function (DUF1797) BVELS4_RS07370 ENOG4108XRC Protein of unknown function (DUF458) BVELS4_RS07400 ENOG4105NQC Flavodoxin BVELS4_RS07420 ENOG4105D8X mechanosensitive ion channel BVELS4_RS07425 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BVELS4_RS07440 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BVELS4_RS07445 ENOG4105D06 uba thif-type nad fad binding protein BVELS4_RS07450 ENOG4105CVM Molybdenum cofactor synthesis domain protein BVELS4_RS07455 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BVELS4_RS07460 ENOG4108ZAF Molybdopterin BVELS4_RS07465 ENOG41067WU Molybdopterin converting factor (Subunit 1) BVELS4_RS07475 ENOG4107X8C Efflux transporter RND family MFP subunit BVELS4_RS07480 ENOG4105C19 ABC transporter BVELS4_RS07485 ENOG4107RBB ABC transporter, permease BVELS4_RS07490 ENOG4105E98 transcriptional regulator DeoR family BVELS4_RS07495 ENOG4105DE4 1-phosphofructokinase BVELS4_RS07500 ENOG4105DM4 PTS System BVELS4_RS07515 ENOG4105C5H ABC transporter BVELS4_RS07520 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BVELS4_RS07545 ENOG4105BZU Histidine kinase BVELS4_RS07555 ENOG4107ZYR domain protein BVELS4_RS07560 ENOG4105CPN adenine deaminase BVELS4_RS07565 ENOG4105CN5 Metallo-Beta-Lactamase BVELS4_RS07570 ENOG4106148 UPF0356 protein BVELS4_RS07575 ENOG4108X4Q Hydrolase BVELS4_RS07580 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BVELS4_RS07595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BVELS4_RS07605 ENOG4107SQU synthase BVELS4_RS07610 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS07615 ENOG4107SQU synthase BVELS4_RS07620 ENOG4107SQU synthase BVELS4_RS07625 ENOG4107SQU synthase BVELS4_RS07630 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS07635 ENOG4105FQP Beta-lactamase BVELS4_RS07645 ENOG4105CPP Dehydrogenase, E1 component BVELS4_RS07650 ENOG4105C7S Dehydrogenase BVELS4_RS07655 ENOG4107QN2 dihydrolipoyl dehydrogenase BVELS4_RS07675 ENOG4105CXN decarboxylase BVELS4_RS07680 ENOG4105WBI UPF0223 protein BVELS4_RS07695 ENOG4105ECY inositol monophosphatase BVELS4_RS07705 ENOG4105D4Y metalloprotease BVELS4_RS07730 ENOG4105CI3 gtp-binding protein typa BVELS4_RS07735 ENOG4105QA2 BVELS4_RS07750 ENOG4108IAB Phoh family BVELS4_RS07760 ENOG4105CSV Glutaminase BVELS4_RS07770 ENOG4105CNI cell division protein FtsW BVELS4_RS07775 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BVELS4_RS07785 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BVELS4_RS07795 ENOG4105BZ9 Cytochrome C oxidase, subunit I BVELS4_RS07800 ENOG4105CCU oxidase (Subunit III) BVELS4_RS07805 ENOG41064X9 cytochrome C oxidase subunit IV BVELS4_RS07820 ENOG41080XQ Signal transduction protein with cbs domains BVELS4_RS07825 ENOG4106UY4 Inherit from COG: Scp-like extracellular BVELS4_RS07850 ENOG4106H78 methyltransferase BVELS4_RS07855 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BVELS4_RS07860 ENOG4105H20 Sporulation integral membrane protein YlbJ BVELS4_RS07865 ENOG4105D78 K07001 NTE family protein BVELS4_RS07870 ENOG41063PX domain protein BVELS4_RS07875 ENOG4105CDE UPF0348 protein BVELS4_RS07880 ENOG4105KNH Nucleic acid-binding protein BVELS4_RS07910 ENOG4108V6E Cell division protein mraZ BVELS4_RS07915 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BVELS4_RS07925 ENOG4105CJN penicillin-binding protein BVELS4_RS07930 ENOG4105CJN penicillin-binding protein BVELS4_RS07935 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BVELS4_RS07940 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BVELS4_RS07945 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BVELS4_RS07950 ENOG4105CNI cell division protein FtsW BVELS4_RS07955 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BVELS4_RS07960 ENOG4105D4A Cell wall formation (By similarity) BVELS4_RS07965 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BVELS4_RS07970 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BVELS4_RS07975 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BVELS4_RS07985 ENOG4105FFI sigma-e processing peptidase spoiiga BVELS4_RS07990 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS08000 ENOG4105DKW ABC transporter BVELS4_RS08010 ENOG4105WR5 sporulation protein, YlmC YmxH family BVELS4_RS08015 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BVELS4_RS08020 ENOG4105DFA alanine racemase domain protein BVELS4_RS08025 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BVELS4_RS08030 ENOG41067XK integral membrane protein BVELS4_RS08035 ENOG4105DBK s4 domain protein BVELS4_RS08045 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BVELS4_RS08055 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BVELS4_RS08060 ENOG4105C34 Pseudouridine synthase BVELS4_RS08065 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BVELS4_RS08075 ENOG4105CXT aspartate transcarbamylase BVELS4_RS08085 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BVELS4_RS08090 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BVELS4_RS08095 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BVELS4_RS08100 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BVELS4_RS08105 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BVELS4_RS08110 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BVELS4_RS08125 ENOG4107RIQ Sulfate adenylate transferase BVELS4_RS08135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BVELS4_RS08140 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BVELS4_RS08145 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BVELS4_RS08160 ENOG4105DSJ YicC domain protein BVELS4_RS08165 ENOG4105KC4 UPF0296 protein BVELS4_RS08170 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BVELS4_RS08180 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BVELS4_RS08185 ENOG4105C25 Primosomal protein n' BVELS4_RS08190 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BVELS4_RS08195 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BVELS4_RS08200 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BVELS4_RS08205 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BVELS4_RS08210 ENOG4108ZF3 Phosphatase BVELS4_RS08215 ENOG4105D9P serine threonine protein kinase BVELS4_RS08220 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BVELS4_RS08225 ENOG4105DJV ribulose-phosphate 3-epimerase BVELS4_RS08230 ENOG4105FJ0 thiamine BVELS4_RS08240 ENOG4105VB9 50S ribosomal protein l28 BVELS4_RS08245 ENOG4108ZAA Alkaline-shock protein BVELS4_RS08260 ENOG4105EJQ L-serine dehydratase BVELS4_RS08265 ENOG4105CB5 ATP-dependent DNA helicase recG BVELS4_RS08270 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BVELS4_RS08275 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BVELS4_RS08280 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BVELS4_RS08285 ENOG4105CHR reductase BVELS4_RS08295 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BVELS4_RS08300 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BVELS4_RS08305 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BVELS4_RS08315 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BVELS4_RS08325 ENOG4105K5M 30s ribosomal protein S16 BVELS4_RS08330 ENOG4108BW8 UPF0109 protein BVELS4_RS08345 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BVELS4_RS08350 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BVELS4_RS08355 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BVELS4_RS08360 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BVELS4_RS08370 ENOG4105VM1 flagellar BVELS4_RS08375 ENOG4105CMV Succinyl-CoA synthetase subunit beta BVELS4_RS08380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BVELS4_RS08385 ENOG4105C79 DNA protecting protein DprA BVELS4_RS08390 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BVELS4_RS08395 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BVELS4_RS08400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BVELS4_RS08405 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BVELS4_RS08410 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BVELS4_RS08420 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BVELS4_RS08425 ENOG4108ZC9 flagellar basal-body rod protein flgc BVELS4_RS08430 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BVELS4_RS08435 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BVELS4_RS08440 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BVELS4_RS08455 ENOG4106YF4 Flagellar biosynthesis chaperone BVELS4_RS08465 ENOG410696Y Flagellar hook-length control protein BVELS4_RS08470 ENOG410822I Flagellar hook capping protein BVELS4_RS08475 ENOG4108JQA flagellar BVELS4_RS08480 ENOG41068WV flagellar FlbD family protein BVELS4_RS08490 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BVELS4_RS08495 ENOG4105DD5 Flagellar motor switch protein BVELS4_RS08500 ENOG4107YTP response regulator receiver protein BVELS4_RS08510 ENOG4105CN7 Flagellar biosynthetic protein FliP BVELS4_RS08515 ENOG4105VS8 Flagellar biosynthetic protein fliq BVELS4_RS08520 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BVELS4_RS08525 ENOG4105D00 flagellar biosynthetic protein flhB BVELS4_RS08530 ENOG4105D7B Flagellar biosynthesis protein flha BVELS4_RS08535 ENOG4105FZW flagellar biosynthesis regulator FlhF BVELS4_RS08545 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BVELS4_RS08550 ENOG4105CBS Chea signal transduction histidine kinase BVELS4_RS08555 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BVELS4_RS08565 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BVELS4_RS08570 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS08580 ENOG4105CE9 30S ribosomal protein S2 BVELS4_RS08590 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BVELS4_RS08595 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BVELS4_RS08600 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BVELS4_RS08605 ENOG4105KNE Phosphatidate cytidylyltransferase BVELS4_RS08615 ENOG4105DZP Membrane-associated zinc metalloprotease BVELS4_RS08620 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BVELS4_RS08625 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BVELS4_RS08630 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BVELS4_RS08635 ENOG4105CHV Transcription elongation factor NusA BVELS4_RS08640 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BVELS4_RS08645 ENOG4105VHM ribosomal protein BVELS4_RS08650 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BVELS4_RS08655 ENOG4105W7A Protein of unknown function (DUF503) BVELS4_RS08660 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BVELS4_RS08665 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BVELS4_RS08670 ENOG4105DTN riboflavin biosynthesis protein ribF BVELS4_RS08675 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BVELS4_RS08680 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BVELS4_RS08690 ENOG4105C1V Peptidase, M16 BVELS4_RS08700 ENOG4105E35 Dipicolinate synthase subunit A BVELS4_RS08705 ENOG4108S0H Dipicolinic acid synthetase, b subunit BVELS4_RS08710 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BVELS4_RS08720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BVELS4_RS08730 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BVELS4_RS08740 ENOG4105CNU cell division protein FtsK BVELS4_RS08745 ENOG4105FDP GntR family transcriptional regulator BVELS4_RS08760 ENOG4105EYF MMPL domain protein BVELS4_RS08775 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BVELS4_RS08780 ENOG4105XZV Protein of unknown function (DUF3243) BVELS4_RS08795 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BVELS4_RS08800 ENOG4105CEV competence damage-inducible protein BVELS4_RS08805 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BVELS4_RS08810 ENOG4108A04 Beta-lactamase BVELS4_RS08820 ENOG4105D48 metallophosphoesterase BVELS4_RS08825 ENOG4105MCT stage V sporulation protein S BVELS4_RS08830 ENOG4105CPQ Dehydrogenase BVELS4_RS08835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BVELS4_RS08840 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BVELS4_RS08860 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BVELS4_RS08870 ENOG4108151 Beta-lactamase domain protein BVELS4_RS08875 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BVELS4_RS08880 ENOG4108JA1 polyketide synthase BVELS4_RS08885 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BVELS4_RS08890 ENOG41062T2 Acyl carrier protein BVELS4_RS08895 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BVELS4_RS08900 ENOG4108MGH Enoyl-CoA hydratase BVELS4_RS08905 ENOG4108KQ6 Enoyl-CoA hydratase BVELS4_RS08910 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS08915 ENOG4107SQU synthase BVELS4_RS08925 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS08935 ENOG4106A3M Cytochrome p-450 BVELS4_RS08940 ENOG4105WFK nuclease BVELS4_RS08945 ENOG4105XPP Protein of unknown function (DUF1275) BVELS4_RS08955 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BVELS4_RS08965 ENOG4105K7W phage-related replication protein BVELS4_RS08970 ENOG4108X3M OsmC Ohr family protein BVELS4_RS08995 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BVELS4_RS09020 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BVELS4_RS09025 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BVELS4_RS09030 ENOG4105U6W MutT NUDIX family protein BVELS4_RS09035 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BVELS4_RS09045 ENOG4106F1P AAA ATPase, central domain protein BVELS4_RS09050 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BVELS4_RS09055 ENOG4105CXI aluminum resistance protein BVELS4_RS09060 ENOG4105KV4 Transcriptional regulator BVELS4_RS09065 ENOG4105C5F glutamine synthetase BVELS4_RS09085 ENOG4105CT4 transporter BVELS4_RS09090 ENOG4105DSG hydrolase family 43 BVELS4_RS09100 ENOG4105C93 Xylose Isomerase BVELS4_RS09105 ENOG4105CMG Carbohydrate kinase BVELS4_RS09110 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BVELS4_RS09140 ENOG4105DQ4 alcohol dehydrogenase BVELS4_RS09165 ENOG4105EPI acetyltransferase, (GNAT) family BVELS4_RS09195 ENOG4108M8W Monooxygenase BVELS4_RS09200 ENOG4108M1A Chitin-binding protein BVELS4_RS09210 ENOG41068WN BVELS4_RS09230 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BVELS4_RS09235 ENOG4105K7W phage-related replication protein BVELS4_RS09260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BVELS4_RS09270 ENOG4108SVB resolvase BVELS4_RS09275 ENOG4105VPS UPF0291 protein BVELS4_RS09280 ENOG4105CV1 Transketolase (EC 2.2.1.1) BVELS4_RS09290 ENOG4105VXM UPF0154 protein BVELS4_RS09300 ENOG4107QIV Cytochrome c biogenesis protein BVELS4_RS09335 ENOG4108I0Z Aconitate hydratase BVELS4_RS09340 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BVELS4_RS09355 ENOG41067CD Small, acid-soluble spore protein Tlp BVELS4_RS09365 ENOG4105MI2 BVELS4_RS09370 ENOG4105W8X HesB YadR YfhF-family protein BVELS4_RS09375 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BVELS4_RS09380 ENOG4105K4P CoA-binding domain protein BVELS4_RS09385 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BVELS4_RS09410 ENOG4105CPQ Dehydrogenase BVELS4_RS09415 ENOG4108UHU Aldolase BVELS4_RS09420 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BVELS4_RS09425 ENOG4105DMW Dehydrogenase reductase BVELS4_RS09435 ENOG4108I5G Major Facilitator superfamily BVELS4_RS09450 ENOG4105FVX BVELS4_RS09490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS09500 ENOG4107SYN Glycosyl hydrolases family 43 BVELS4_RS09525 ENOG4105DTD Dehydrogenase BVELS4_RS09530 ENOG4108IIH CoA-transferase subunit B BVELS4_RS09535 ENOG4105D6N CoA-transferase, subunit a BVELS4_RS09540 ENOG4105CY2 Citrate transporter BVELS4_RS09545 ENOG4106A3M Cytochrome p-450 BVELS4_RS09550 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BVELS4_RS09555 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BVELS4_RS09560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BVELS4_RS09565 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BVELS4_RS09570 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) BVELS4_RS09580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BVELS4_RS09585 ENOG4107T5V SNARE associated Golgi BVELS4_RS09590 ENOG4107QX3 carboxylase BVELS4_RS09595 ENOG4105E39 Enoyl-CoA hydratase BVELS4_RS09600 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BVELS4_RS09605 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BVELS4_RS09610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BVELS4_RS09615 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS09620 ENOG4105C1G acyl-Coa dehydrogenase BVELS4_RS09625 ENOG4105F32 YngK protein BVELS4_RS09635 ENOG4106U2H Protein of unknown function (DUF1360) BVELS4_RS09645 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS09650 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS09660 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS09665 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BVELS4_RS09670 ENOG4108N2V aldose 1-epimerase BVELS4_RS09675 ENOG4107QJQ Mate efflux family protein BVELS4_RS09700 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BVELS4_RS09705 ENOG4108RWP Major Facilitator Superfamily protein BVELS4_RS09710 ENOG4105WAB arsR family transcriptional regulator BVELS4_RS09715 ENOG4105C22 threonyL-tRNA synthetase BVELS4_RS09720 ENOG4108KSA LysR family transcriptional regulator BVELS4_RS09725 ENOG4105CB2 alcohol dehydrogenase BVELS4_RS09730 ENOG4105BZ8 glutamate synthase BVELS4_RS09735 ENOG4105CBC glutamate synthase BVELS4_RS09740 ENOG4105C5Q Transcriptional regulator BVELS4_RS09745 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BVELS4_RS09775 ENOG4108UB7 BVELS4_RS09780 ENOG4105IE8 Alpha-ketoglutarate permease BVELS4_RS09785 ENOG4107U6E carbohydrate kinase FGGY BVELS4_RS09790 ENOG4108M3J Dehydrogenase BVELS4_RS09795 ENOG4108J2R molybdopterin oxidoreductase BVELS4_RS09820 ENOG4106ANW SMI1_KNR4 BVELS4_RS09830 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BVELS4_RS09865 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BVELS4_RS09890 ENOG41068G1 BVELS4_RS09910 ENOG4108FKH Transglycosylase SLT domain BVELS4_RS10035 ENOG4108Z7R Chaperone CsaA BVELS4_RS10040 ENOG4105FTV AraC Family Transcriptional Regulator BVELS4_RS10050 ENOG4108W8B Beta-lactamase domain protein BVELS4_RS10060 ENOG4105KTU Transcriptional regulator, arsr family BVELS4_RS10070 ENOG4108SJC Membrane BVELS4_RS10095 ENOG41069ER domain protein BVELS4_RS10100 ENOG4105C9U ATP-dependent DNA helicase RecQ BVELS4_RS10110 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BVELS4_RS10115 ENOG4105SCY DNAK suppressor BVELS4_RS10160 ENOG4105C26 Dehydrogenase BVELS4_RS10170 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BVELS4_RS10175 ENOG4105C8J )-transporter BVELS4_RS10180 ENOG4105C09 Bile acid BVELS4_RS10190 ENOG4105C7S Dehydrogenase BVELS4_RS10195 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BVELS4_RS10200 ENOG4107T89 von Willebrand factor, type A BVELS4_RS10205 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BVELS4_RS10215 ENOG4105K4H Nlp p60 protein BVELS4_RS10220 ENOG41087PP glycosyltransferase MGT family BVELS4_RS10230 ENOG4107QMU Mate efflux family protein BVELS4_RS10235 ENOG4106SCS STAS domain BVELS4_RS10255 ENOG4105FR1 rard protein BVELS4_RS10270 ENOG41090U3 tautomerase BVELS4_RS10290 ENOG4105FBA Phospholipase Carboxylesterase BVELS4_RS10305 ENOG4105E1V na solute symporter BVELS4_RS10315 ENOG4105CS2 ec 3.2.1.21 BVELS4_RS10320 ENOG4108S3Y transcriptional regulator BVELS4_RS10340 ENOG4108VXD carboxy-peptidase BVELS4_RS10345 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BVELS4_RS10355 ENOG4106Z5R BVELS4_RS10360 ENOG410841Q phosphoesterase PA-phosphatase related protein BVELS4_RS10395 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BVELS4_RS10400 ENOG4108TSC N-acetyltransferase BVELS4_RS10405 ENOG4107S4Y M20 DapE family protein YgeY BVELS4_RS10420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BVELS4_RS10510 ENOG4105C26 Dehydrogenase BVELS4_RS10520 ENOG4106ANW SMI1_KNR4 BVELS4_RS10535 ENOG4107Y9E nuclease BVELS4_RS10550 ENOG4105E0X reductase BVELS4_RS10555 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BVELS4_RS10565 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BVELS4_RS10570 ENOG41090WU lipolytic protein G-D-S-L family BVELS4_RS10575 ENOG4108KF3 Electron transport protein SCO1 SenC BVELS4_RS10585 ENOG4105C7B Threonine dehydratase BVELS4_RS10595 ENOG4108UT2 hemolysin iii BVELS4_RS10605 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BVELS4_RS10610 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BVELS4_RS10620 ENOG4107YX5 Pfam:DUF548 BVELS4_RS10625 ENOG4108Y6J UPF0403 protein BVELS4_RS10630 ENOG4105C01 Dihydroxy-acid dehydratase BVELS4_RS10645 ENOG4108V06 Glutathione peroxidase BVELS4_RS10650 ENOG4105CVG Homoserine O-transsuccinylase BVELS4_RS10695 ENOG41081VK Ribonuclease BVELS4_RS10720 ENOG410890F Dynamin family BVELS4_RS10735 ENOG41065KQ synthase BVELS4_RS10755 ENOG410900G Protein of unknown function (DUF421) BVELS4_RS10770 ENOG4105C2W permease BVELS4_RS10775 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BVELS4_RS10780 ENOG4105CTD carboxy-peptidase BVELS4_RS10785 ENOG4105DVT helicase BVELS4_RS10800 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BVELS4_RS10810 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BVELS4_RS10815 ENOG4108UKS UPF0398 protein BVELS4_RS10830 ENOG4107X2U Inherit from COG: Exonuclease-like protein BVELS4_RS10835 ENOG4108I5C dEAD DEAH box helicase BVELS4_RS10880 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BVELS4_RS10885 ENOG4105BZ4 penicillin-binding protein BVELS4_RS10895 ENOG4105CSM endonuclease III BVELS4_RS10905 ENOG4105C5S asparaginyl-tRNA synthetase BVELS4_RS10910 ENOG4105CHM Aminotransferase BVELS4_RS10920 ENOG4105YAC BVELS4_RS10925 ENOG4105DVT helicase BVELS4_RS10930 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BVELS4_RS10940 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BVELS4_RS10950 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BVELS4_RS10955 ENOG4105CPK Glycosyl transferase (Group 1 BVELS4_RS10960 ENOG4105FJR Lmbe family BVELS4_RS10965 ENOG4108Z5K methylglyoxal synthase BVELS4_RS10970 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BVELS4_RS10975 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BVELS4_RS10980 ENOG4108JYZ YitT family BVELS4_RS10985 ENOG4105F0F Oxalate decarboxylase BVELS4_RS11005 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BVELS4_RS11025 ENOG41068YB TPR repeat-containing protein BVELS4_RS11035 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BVELS4_RS11045 ENOG4105CIH Imidazole acetol-phosphate transaminase BVELS4_RS11055 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BVELS4_RS11060 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BVELS4_RS11065 ENOG4105DK0 Indole-3-glycerol phosphate synthase BVELS4_RS11075 ENOG4105CRQ synthase (Component I) BVELS4_RS11080 ENOG4105KHN chorismate mutase BVELS4_RS11090 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BVELS4_RS11095 ENOG4105BZU Histidine kinase BVELS4_RS11100 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BVELS4_RS11105 ENOG4105EAH synthase BVELS4_RS11110 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BVELS4_RS11115 ENOG4105XXQ heptaprenyl diphosphate synthase component I BVELS4_RS11120 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BVELS4_RS11125 ENOG4105EUJ GTP cyclohydrolase i BVELS4_RS11130 ENOG4105K70 DNA-binding protein BVELS4_RS11135 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BVELS4_RS11150 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BVELS4_RS11155 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BVELS4_RS11175 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BVELS4_RS11180 ENOG4105CAT Cytidine monophosphate kinase BVELS4_RS11195 ENOG4105MSI germination protein ypeb BVELS4_RS11205 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BVELS4_RS11210 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BVELS4_RS11225 ENOG4107RGJ metallophosphoesterase BVELS4_RS11240 ENOG4105I7S Abortive infection protein BVELS4_RS11245 ENOG4105C9U ATP-dependent DNA helicase RecQ BVELS4_RS11250 ENOG4105T7X BVELS4_RS11260 ENOG4108SAX Membrane BVELS4_RS11265 ENOG4108JQ1 Dehydrogenase BVELS4_RS11280 ENOG4105BZU Histidine kinase BVELS4_RS11285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS11290 ENOG4105CRE cytochrome C BVELS4_RS11295 ENOG4107TWT Cytochrome c biogenesis protein BVELS4_RS11305 ENOG4105FE9 pseudouridine synthase BVELS4_RS11315 ENOG4108JIC nucleoside recognition domain protein BVELS4_RS11320 ENOG4105DZ1 carboxypeptidase BVELS4_RS11330 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BVELS4_RS11335 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BVELS4_RS11355 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BVELS4_RS11360 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BVELS4_RS11365 ENOG4108R6K riboflavin synthase, subunit alpha BVELS4_RS11390 ENOG4107ZE5 PPIases accelerate the folding of proteins BVELS4_RS11395 ENOG4105PTM secreted protein BVELS4_RS11400 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BVELS4_RS11410 ENOG4105G6R Stage v sporulation protein ae BVELS4_RS11420 ENOG4105CZ3 stage V sporulation protein ad BVELS4_RS11425 ENOG41090VF Stage v sporulation protein ac BVELS4_RS11440 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS11445 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BVELS4_RS11450 ENOG41082AN stage II sporulation protein BVELS4_RS11455 ENOG4105DZ1 carboxypeptidase BVELS4_RS11460 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BVELS4_RS11465 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BVELS4_RS11470 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BVELS4_RS11480 ENOG4105I3K Ferric uptake regulator, Fur family BVELS4_RS11485 ENOG4105MZ9 stage II sporulation protein m BVELS4_RS11505 ENOG4105DFD Na H antiporter BVELS4_RS11510 ENOG4108IJ0 Aspartate ammonia-lyase BVELS4_RS11515 ENOG4105HDK L-asparaginase BVELS4_RS11520 ENOG4108IMY Transcriptional regulator BVELS4_RS11530 ENOG4108YZ4 nudix hydrolase BVELS4_RS11540 ENOG4105CPC Aldo Keto reductase BVELS4_RS11560 ENOG4106HZJ BVELS4_RS11565 ENOG4105RHY Pfam:UPF0157 BVELS4_RS11570 ENOG4105KAC Antibiotic biosynthesis monooxygenase BVELS4_RS11575 ENOG4108XET gCN5-related N-acetyltransferase BVELS4_RS11580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BVELS4_RS11595 ENOG4105C02 permease BVELS4_RS11605 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BVELS4_RS11610 ENOG4105CS9 pantothenic acid kinase BVELS4_RS11620 ENOG4108IXY short-chain dehydrogenase reductase BVELS4_RS11625 ENOG41069FQ Metallo-beta-lactamase superfamily BVELS4_RS11630 ENOG4105II7 pyrroline-5-carboxylate reductase BVELS4_RS11635 ENOG4108KQ6 Enoyl-CoA hydratase BVELS4_RS11640 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BVELS4_RS11645 ENOG4106A3M Cytochrome p-450 BVELS4_RS11660 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS11665 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS11675 ENOG4105C0W non-ribosomal peptide synthetase BVELS4_RS11685 ENOG4105CHR reductase BVELS4_RS11690 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS11705 ENOG4107QKG PfaD family BVELS4_RS11710 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BVELS4_RS11715 ENOG4108K70 Transcriptional regulator BVELS4_RS11725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVELS4_RS11735 ENOG410861F 50S ribosomal protein L33 BVELS4_RS11740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BVELS4_RS11745 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BVELS4_RS11750 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BVELS4_RS11755 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BVELS4_RS11765 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BVELS4_RS11770 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BVELS4_RS11775 ENOG4108HNZ carboxyl transferase BVELS4_RS11780 ENOG4108ZVT methylmalonyl-coA epimerase BVELS4_RS11790 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BVELS4_RS11795 ENOG4108QEG Membrane BVELS4_RS11800 ENOG4105CDA abc transporter atp-binding protein BVELS4_RS11805 ENOG4105E5Q amino acid AbC transporter BVELS4_RS11810 ENOG4108HW3 (ABC) transporter BVELS4_RS11815 ENOG4108Y6J UPF0403 protein BVELS4_RS11820 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BVELS4_RS11825 ENOG4105C7S Dehydrogenase BVELS4_RS11830 ENOG4105CPP Dehydrogenase, E1 component BVELS4_RS11845 ENOG4105CKM Branched-chain carboxylic acid kinase BVELS4_RS11850 ENOG4107RDP Dehydrogenase BVELS4_RS11860 ENOG4108JUB Transcriptional regulator BVELS4_RS11865 ENOG4106CCJ Protein of unknown function (DUF2627) BVELS4_RS11870 ENOG4105CR4 methylisocitrate lyase BVELS4_RS11875 ENOG4105DXD 2-methylcitrate dehydratase BVELS4_RS11885 ENOG4105C1G acyl-Coa dehydrogenase BVELS4_RS11890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BVELS4_RS11900 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BVELS4_RS11905 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BVELS4_RS11930 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BVELS4_RS11945 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BVELS4_RS11950 ENOG4107QQR Sporulation BVELS4_RS11955 ENOG4105S1Z Stage IV sporulation protein B BVELS4_RS11960 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BVELS4_RS11965 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BVELS4_RS11970 ENOG4105DX0 Hemolysin A BVELS4_RS11975 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BVELS4_RS11980 ENOG4105CTB Polyprenyl synthetase BVELS4_RS11985 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BVELS4_RS11990 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BVELS4_RS11995 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BVELS4_RS12000 ENOG4105M7K Involved in the transcription termination process (By similarity) BVELS4_RS12005 ENOG4108ZSR alkaline shock protein BVELS4_RS12010 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BVELS4_RS12030 ENOG410644B Stage III sporulation protein af BVELS4_RS12040 ENOG4105KQ4 Stage iii sporulation protein ad BVELS4_RS12045 ENOG4108CQH stage III sporulation protein AC BVELS4_RS12050 ENOG4105KR5 Stage iii sporulation protein BVELS4_RS12055 ENOG4105CD2 stage iii sporulation protein aa BVELS4_RS12065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BVELS4_RS12070 ENOG4105DC7 peptidase M24 BVELS4_RS12080 ENOG4105CBJ Metal-dependent enzyme BVELS4_RS12100 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BVELS4_RS12105 ENOG4105WZW rhodanese family BVELS4_RS12110 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BVELS4_RS12120 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BVELS4_RS12125 ENOG4105C0D helicase BVELS4_RS12140 ENOG4108IMY Transcriptional regulator BVELS4_RS12150 ENOG4105VFR signal peptidase BVELS4_RS12235 ENOG4105C5X domain protein BVELS4_RS12280 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BVELS4_RS12295 ENOG41068DG YceG-like family BVELS4_RS12300 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BVELS4_RS12305 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BVELS4_RS12310 ENOG4105E2Z phosphate ABC transporter (Permease BVELS4_RS12315 ENOG4105C8U phosphate abc transporter BVELS4_RS12320 ENOG4105CVA phosphate BVELS4_RS12325 ENOG4107RF6 penicillin-binding protein BVELS4_RS12335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BVELS4_RS12340 ENOG4105SXS Protein of unknown function (DUF456) BVELS4_RS12355 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BVELS4_RS12360 ENOG41063Y9 BVELS4_RS12365 ENOG4108U5J '-nucleotidase BVELS4_RS12370 ENOG4105N80 Ferric uptake regulator, Fur family BVELS4_RS12375 ENOG4108JYZ YitT family BVELS4_RS12380 ENOG41069ZM Protein of unknown function (DUF2624) BVELS4_RS12385 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BVELS4_RS12400 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BVELS4_RS12405 ENOG4105EGD dinuclear metal center protein, YbgI family BVELS4_RS12420 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS12425 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BVELS4_RS12430 ENOG4108UPT UPF0178 protein BVELS4_RS12435 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BVELS4_RS12445 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BVELS4_RS12450 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BVELS4_RS12455 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BVELS4_RS12465 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BVELS4_RS12470 ENOG4105KG3 cytidine deaminase BVELS4_RS12475 ENOG4107YR5 Diacylglycerol kinase BVELS4_RS12480 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BVELS4_RS12485 ENOG4105CTJ Metal Dependent Phosphohydrolase BVELS4_RS12490 ENOG4105C9A Phoh family BVELS4_RS12495 ENOG4105EI1 sporulation protein yqfd BVELS4_RS12500 ENOG41068P3 sporulation protein YqfC BVELS4_RS12510 ENOG4105DI5 UPF0365 protein BVELS4_RS12515 ENOG4105F7J membrane-bound serine protease BVELS4_RS12520 ENOG4105KTH gatB Yqey BVELS4_RS12535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BVELS4_RS12540 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BVELS4_RS12545 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BVELS4_RS12550 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BVELS4_RS12555 ENOG4105CFG Acts as a chaperone (By similarity) BVELS4_RS12560 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BVELS4_RS12565 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BVELS4_RS12570 ENOG4105CSA Coproporphyrinogen iii oxidase BVELS4_RS12575 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BVELS4_RS12585 ENOG4108ZRV stage ii sporulation protein p BVELS4_RS12590 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BVELS4_RS12595 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BVELS4_RS12600 ENOG4105TQK DNA polymerase iii, delta' subunit BVELS4_RS12615 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BVELS4_RS12620 ENOG4108UK2 deaminase BVELS4_RS12625 ENOG4105KQC Competence protein BVELS4_RS12635 ENOG4108D32 Methyltransferase BVELS4_RS12645 ENOG4108WF2 Metal Dependent Phosphohydrolase BVELS4_RS12650 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BVELS4_RS12655 ENOG410812S Rna-binding protein BVELS4_RS12660 ENOG4105E2X shikimate dehydrogenase BVELS4_RS12665 ENOG4105CQW ribosome biogenesis GTPase YqeH BVELS4_RS12670 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BVELS4_RS12690 ENOG41080BT SNARE associated Golgi BVELS4_RS12705 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS12720 ENOG41086D8 Transcriptional regulator BVELS4_RS12730 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BVELS4_RS12740 ENOG4108J8C transporter major facilitator family protein BVELS4_RS12750 ENOG4108U7W acetyltransferase BVELS4_RS12765 ENOG4105DQF Hydrolase BVELS4_RS12780 ENOG4105DG6 mannose-6-phosphate isomerase BVELS4_RS12785 ENOG4105DM4 PTS System BVELS4_RS12800 ENOG4108Z66 YbaK ebsC protein BVELS4_RS12805 ENOG4107RSM transcriptional regulator BVELS4_RS12810 ENOG4105D94 Major Facilitator Superfamily BVELS4_RS12815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BVELS4_RS12820 ENOG41082JN Transcriptional regulator BVELS4_RS12840 ENOG4105TMB Formate nitrite transporter BVELS4_RS12845 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BVELS4_RS12850 ENOG4108JB9 formate dehydrogenase BVELS4_RS12865 ENOG4105C28 cystathionine BVELS4_RS12895 ENOG4107XRG penicillin-binding protein BVELS4_RS12900 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BVELS4_RS12915 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BVELS4_RS12940 ENOG41068G1 BVELS4_RS12950 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BVELS4_RS12960 ENOG4108FKH Transglycosylase SLT domain BVELS4_RS13015 ENOG4105CAR Terminase, large subunit BVELS4_RS13050 ENOG410682Q Phage transcriptional regulator, ArpU BVELS4_RS13210 ENOG4108IMY Transcriptional regulator BVELS4_RS13230 ENOG4105CFP Peptidase U32 BVELS4_RS13235 ENOG4105XYU peptidase (U32 family) BVELS4_RS13245 ENOG4105HHA aminodeoxychorismate lyase BVELS4_RS13255 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BVELS4_RS13260 ENOG4105VBH UPF0297 protein BVELS4_RS13265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BVELS4_RS13270 ENOG4105C02 permease BVELS4_RS13275 ENOG4105CDA abc transporter atp-binding protein BVELS4_RS13280 ENOG4105CT1 (ABC) transporter BVELS4_RS13285 ENOG4105EAD ABC transporter BVELS4_RS13290 ENOG4105DRP amino acid AbC transporter BVELS4_RS13300 ENOG41060CR BVELS4_RS13310 ENOG4105C7H Helicase, RecD TraA family BVELS4_RS13320 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BVELS4_RS13325 ENOG4105C3J Cysteine desulfurase BVELS4_RS13335 ENOG4105D1H recombination factor protein RarA BVELS4_RS13340 ENOG4105CUZ uba thif-type nad fad binding protein BVELS4_RS13350 ENOG4105C9M aspartyl-trna synthetase BVELS4_RS13355 ENOG4105CUT histidyl-tRNA synthetase BVELS4_RS13365 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BVELS4_RS13370 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BVELS4_RS13375 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BVELS4_RS13385 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BVELS4_RS13390 ENOG41067VP Protein of unknown function (DUF1049) BVELS4_RS13395 ENOG4105NCW Trka-c domain protein BVELS4_RS13400 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BVELS4_RS13410 ENOG4105CKP Polysaccharide Biosynthesis Protein BVELS4_RS13415 ENOG4108QG2 Membrane BVELS4_RS13420 ENOG4105NAP BVELS4_RS13425 ENOG4105VIE preprotein translocase, subunit YajC BVELS4_RS13430 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BVELS4_RS13435 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BVELS4_RS13440 ENOG41061AI Protein of unknown function (DUF2905) BVELS4_RS13445 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BVELS4_RS13450 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BVELS4_RS13465 ENOG4106678 morphogenetic protein associated with SpoVID BVELS4_RS13470 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BVELS4_RS13475 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BVELS4_RS13480 ENOG4108IYU L-aspartate oxidase BVELS4_RS13495 ENOG4105CQC Prephenate dehydratase BVELS4_RS13505 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BVELS4_RS13515 ENOG4105K46 50S ribosomal protein l27 BVELS4_RS13520 ENOG4105X36 (ribosomal) protein BVELS4_RS13525 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BVELS4_RS13540 ENOG4107QMS site-determining protein BVELS4_RS13545 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BVELS4_RS13550 ENOG4105YHC Rod shape-determining protein MreD BVELS4_RS13560 ENOG4105DFF Rod shape-determining protein mreb BVELS4_RS13565 ENOG4105W5Q DNA repair protein (RadC BVELS4_RS13570 ENOG4108Z03 MAF-like protein BVELS4_RS13580 ENOG4106A3R peptidase BVELS4_RS13585 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BVELS4_RS13590 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BVELS4_RS13600 ENOG4106AR7 Spore coat protein BVELS4_RS13605 ENOG41068KH stage VI sporulation protein D BVELS4_RS13610 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BVELS4_RS13615 ENOG4105D52 delta-aminolevulinic acid dehydratase BVELS4_RS13625 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BVELS4_RS13635 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BVELS4_RS13645 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BVELS4_RS13650 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BVELS4_RS13655 ENOG4108IUQ atp-dependent protease BVELS4_RS13660 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BVELS4_RS13665 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BVELS4_RS13675 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BVELS4_RS13680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BVELS4_RS13685 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BVELS4_RS13695 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BVELS4_RS13700 ENOG4108ZP8 Acetolactate synthase small subunit BVELS4_RS13705 ENOG4105C7K acetolactate synthase BVELS4_RS13730 ENOG4105M59 Phosphodiesterase, mj0936 family BVELS4_RS13735 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BVELS4_RS13740 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BVELS4_RS13745 ENOG4108XJQ germination protein BVELS4_RS13750 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BVELS4_RS13755 ENOG41067TZ transcriptional regulator, MarR family BVELS4_RS13760 ENOG4105PFC Transcriptional regulator BVELS4_RS13770 ENOG4105E33 succinate dehydrogenase BVELS4_RS13780 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BVELS4_RS13790 ENOG4105CFH Aspartokinase BVELS4_RS13795 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BVELS4_RS13800 ENOG4105K63 Thioredoxin BVELS4_RS13805 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BVELS4_RS13810 ENOG4105C10 Electron transfer flavoprotein BVELS4_RS13815 ENOG4105BZJ Electron transfer flavoprotein BVELS4_RS13820 ENOG41060WC Enoyl-CoA hydratase BVELS4_RS13825 ENOG4107Z3H Transcriptional regulator, TetR family BVELS4_RS13830 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS13835 ENOG4108YV3 Protein of unknown function (DUF2711) BVELS4_RS13845 ENOG4105C98 muts2 protein BVELS4_RS13850 ENOG4105DCG PHP domain protein BVELS4_RS13865 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BVELS4_RS13870 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BVELS4_RS13875 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BVELS4_RS13880 ENOG4108RWN rrna methyltransferase BVELS4_RS13885 ENOG41067MF small acid-soluble spore protein BVELS4_RS13895 ENOG4105CQB FAD linked oxidase domain protein BVELS4_RS13900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BVELS4_RS13910 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BVELS4_RS13915 ENOG4105DRS transport system, permease BVELS4_RS13930 ENOG4108MDK Dehydrogenase BVELS4_RS13940 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BVELS4_RS13945 ENOG4105EF1 ribulokinase BVELS4_RS13955 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BVELS4_RS13960 ENOG4105CN9 Peptidase m42 family protein BVELS4_RS13970 ENOG410696E Membrane BVELS4_RS13975 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BVELS4_RS13980 ENOG4105VJV 50s ribosomal protein L35 BVELS4_RS13985 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BVELS4_RS13990 ENOG41067MG lrgb family BVELS4_RS14000 ENOG4105DY9 regulatoR BVELS4_RS14005 ENOG4108HRK Histidine kinase BVELS4_RS14015 ENOG4105C22 threonyL-tRNA synthetase BVELS4_RS14020 ENOG4108TDW sporulation protein YtxC BVELS4_RS14045 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BVELS4_RS14050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BVELS4_RS14055 ENOG4105KVH Transcriptional regulator BVELS4_RS14060 ENOG4105F27 Major Facilitator BVELS4_RS14065 ENOG4105CV8 reductase BVELS4_RS14070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BVELS4_RS14080 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BVELS4_RS14085 ENOG4105C2M dna polymerase I BVELS4_RS14090 ENOG4105BZU Histidine kinase BVELS4_RS14095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS14105 ENOG4108HMX isocitrate dehydrogenase (NADP) BVELS4_RS14110 ENOG4105BZN citrate synthase BVELS4_RS14125 ENOG4105G7B Protein of unknown function (DUF2992) BVELS4_RS14135 ENOG4108REF Sporulation integral membrane protein ytvi BVELS4_RS14140 ENOG4105FS0 cytoplasmic membrane protein BVELS4_RS14145 ENOG4105CA9 Pyruvate kinase BVELS4_RS14150 ENOG4105CTQ phosphohexokinase BVELS4_RS14155 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BVELS4_RS14160 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BVELS4_RS14165 ENOG4105C6K Malic enzyme BVELS4_RS14170 ENOG4105C0B DNA polymerase III (alpha subunit) BVELS4_RS14175 ENOG4105VV2 BVELS4_RS14185 ENOG4106EVM BVELS4_RS14190 ENOG4105SFS phosphoesterase RecJ domain protein BVELS4_RS14205 ENOG4105E8R UPF0173 metal-dependent hydrolase BVELS4_RS14215 ENOG4105CH7 arginosuccinase BVELS4_RS14220 ENOG4105CDH Citrulline--aspartate ligase BVELS4_RS14225 ENOG4105EPU Molybdenum cofactor synthesis domain protein BVELS4_RS14235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BVELS4_RS14245 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BVELS4_RS14250 ENOG4105KBJ sporulation protein ytfj BVELS4_RS14260 ENOG4105VK3 rdd domain containing protein BVELS4_RS14265 ENOG4105D07 Signal peptide peptidase, SppA BVELS4_RS14270 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BVELS4_RS14275 ENOG4105EFZ amidohydrolase BVELS4_RS14280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BVELS4_RS14290 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BVELS4_RS14315 ENOG4105U5Y Transcriptional regulator BVELS4_RS14325 ENOG4105BZU Histidine kinase BVELS4_RS14335 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BVELS4_RS14340 ENOG4105C26 Dehydrogenase BVELS4_RS14365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BVELS4_RS14380 ENOG4108Z0Z intracellular protease Pfpi family BVELS4_RS14400 ENOG4108NGU Transcriptional regulator BVELS4_RS14415 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BVELS4_RS14425 ENOG4105F1V Acetoin utilization protein BVELS4_RS14430 ENOG4105W87 Cbs domain BVELS4_RS14435 ENOG4105DGU Histone deacetylase BVELS4_RS14440 ENOG4105ER2 Ompa motb domain protein BVELS4_RS14445 ENOG4107R0U MotA TolQ exbB proton channel BVELS4_RS14450 ENOG4105ETE Transcriptional regulator (LacI family BVELS4_RS14455 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BVELS4_RS14475 ENOG4105DFU Cell wall formation (By similarity) BVELS4_RS14485 ENOG4108VDD TRNA binding domain protein BVELS4_RS14500 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BVELS4_RS14515 ENOG4105C6K Malic enzyme BVELS4_RS14520 ENOG4105C8F Beta-lactamase domain protein BVELS4_RS14525 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BVELS4_RS14535 ENOG4108V15 phosphotransferase enzyme family BVELS4_RS14550 ENOG4107F58 2'-5' rna ligase BVELS4_RS14555 ENOG4105C6T cysteine synthase BVELS4_RS14560 ENOG4107QSE Dipeptidase BVELS4_RS14565 ENOG4105C7N Xanthine uracil vitamin C permease BVELS4_RS14580 ENOG4105YW5 deoR family transcriptional regulator BVELS4_RS14595 ENOG4105CBX hi0933 family BVELS4_RS14600 ENOG4105C94 Transporter BVELS4_RS14640 ENOG41085GJ domain protein BVELS4_RS14645 ENOG4105C8T Leucyl-tRNA synthetase BVELS4_RS14655 ENOG4105BZU Histidine kinase BVELS4_RS14660 ENOG410605W Major Facilitator BVELS4_RS14675 ENOG4105C19 ABC transporter BVELS4_RS14680 ENOG4105EWM Histidine kinase BVELS4_RS14690 ENOG4107R34 abc transporter permease protein BVELS4_RS14695 ENOG4105C19 ABC transporter BVELS4_RS14715 ENOG4105DVE abc transporter atp-binding protein BVELS4_RS14720 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BVELS4_RS14730 ENOG4105N5T Radical SAM Protein BVELS4_RS14750 ENOG4105E8V Alpha Beta Hydrolase Fold protein BVELS4_RS14755 ENOG4108Z0R Transferase BVELS4_RS14760 ENOG4105C85 amino acid BVELS4_RS14765 ENOG4105CAQ asparagine synthetase BVELS4_RS14770 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BVELS4_RS14775 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BVELS4_RS14790 ENOG4105D2X ABC transporter substrate-binding protein BVELS4_RS14800 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BVELS4_RS14815 ENOG4108RMU ferritin dps family protein BVELS4_RS14830 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BVELS4_RS14835 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BVELS4_RS14840 ENOG4108V2W Carbonate dehydratase BVELS4_RS14845 ENOG4105NRA 50s ribosomal protein l31 type b BVELS4_RS14865 ENOG4105DTQ mandelate racemase muconate lactonizing BVELS4_RS14870 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS14875 ENOG4108IPT Naphthoate synthase BVELS4_RS14880 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BVELS4_RS14885 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BVELS4_RS14890 ENOG4105E4F Isochorismate synthase BVELS4_RS15025 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BVELS4_RS15030 ENOG4105DZ6 Band 7 protein BVELS4_RS15040 ENOG4106DF1 BVELS4_RS15045 ENOG4108VNY MOSC domain protein BVELS4_RS15050 ENOG4108JB8 alcohol dehydrogenase BVELS4_RS15060 ENOG4105TRT Transcriptional regulator BVELS4_RS15075 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BVELS4_RS15080 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BVELS4_RS15100 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BVELS4_RS15110 ENOG4105EE0 oxidoreductase BVELS4_RS15115 ENOG4108Z0Z intracellular protease Pfpi family BVELS4_RS15120 ENOG4105C8Q Methyl-accepting chemotaxis BVELS4_RS15125 ENOG4105C8Q Methyl-accepting chemotaxis BVELS4_RS15130 ENOG4105C8Q Methyl-accepting chemotaxis BVELS4_RS15135 ENOG4105C8Q Methyl-accepting chemotaxis BVELS4_RS15150 ENOG4105EA8 2-Nitropropane dioxygenase BVELS4_RS15155 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BVELS4_RS15165 ENOG4105C37 (CBS) domain BVELS4_RS15180 ENOG4107PBV potassium channel BVELS4_RS15185 ENOG4107PBV potassium channel BVELS4_RS15200 ENOG4107QYV phosphohexose isomerase BVELS4_RS15210 ENOG4105CHJ isochorismatase hydrolase BVELS4_RS15220 ENOG4107QW4 alcohol dehydrogenase BVELS4_RS15225 ENOG4105WG9 Conserved Protein BVELS4_RS15235 ENOG4105CHM Aminotransferase BVELS4_RS15240 ENOG4108ZB6 transcriptional regulator AsnC family BVELS4_RS15245 ENOG4108MUZ hydrolase BVELS4_RS15255 ENOG4105C87 Aminotransferase class I and II BVELS4_RS15260 ENOG4108HGU Histidine kinase BVELS4_RS15265 ENOG4105Y38 Kinase-associated protein B BVELS4_RS15280 ENOG4105BZ4 penicillin-binding protein BVELS4_RS15285 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BVELS4_RS15300 ENOG4108MRH transcriptional regulatory protein BVELS4_RS15305 ENOG4105DIH basic membrane BVELS4_RS15310 ENOG4108JQ9 ABC transporter BVELS4_RS15315 ENOG4105UIB (ABC) transporter BVELS4_RS15330 ENOG4105D65 subunit l BVELS4_RS15335 ENOG4105HC0 Na H antiporter BVELS4_RS15340 ENOG4108ZE9 Monovalent cation H antiporter subunit C BVELS4_RS15345 ENOG4108JPZ Monovalent cation H antiporter subunit D BVELS4_RS15350 ENOG4105SC1 monovalent cation H antiporter subunit E BVELS4_RS15360 ENOG4105KJM monovalent cation h antiporter subunit g BVELS4_RS15365 ENOG4105KA0 thioesterase Superfamily protein BVELS4_RS15375 ENOG4105BZU Histidine kinase BVELS4_RS15400 ENOG4105D58 Diguanylate phosphodiesterase BVELS4_RS15405 ENOG4105DAP Nicotinate phosphoribosyltransferase BVELS4_RS15430 ENOG4105C02 permease BVELS4_RS15445 ENOG410904N short-chain dehydrogenase reductase BVELS4_RS15480 ENOG4108K8K Transcriptional regulator BVELS4_RS15485 ENOG4105DCF alanine dehydrogenase BVELS4_RS15495 ENOG4105WQT MbtH domain protein BVELS4_RS15500 ENOG4105CEY Amp-dependent synthetase and ligase BVELS4_RS15505 ENOG4105WQI isochorismatase BVELS4_RS15510 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BVELS4_RS15515 ENOG4105E4F Isochorismate synthase BVELS4_RS15520 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BVELS4_RS15525 ENOG4105NIV Esterase BVELS4_RS15545 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BVELS4_RS15555 ENOG41069ER domain protein BVELS4_RS15570 ENOG4105CEP NADH dehydrogenase BVELS4_RS15585 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BVELS4_RS15600 ENOG4105CJ1 ABC, transporter BVELS4_RS15620 ENOG4105D9U N-acetyltransferase BVELS4_RS15625 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BVELS4_RS15630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BVELS4_RS15635 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BVELS4_RS15645 ENOG4105ZKE UPF0349 protein BVELS4_RS15660 ENOG41083MR nifu domain-containing protein BVELS4_RS15665 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BVELS4_RS15670 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BVELS4_RS15675 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BVELS4_RS15680 ENOG4105D6E homoserine dehydrogenase BVELS4_RS15690 ENOG4108W5N phosphatidylglycerophosphatase a BVELS4_RS15695 ENOG4105D4U had-superfamily hydrolase, subfamily iia BVELS4_RS15705 ENOG4105MMD transcriptional regulator BVELS4_RS15710 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BVELS4_RS15715 ENOG4105FAA peptidase M23 BVELS4_RS15720 ENOG4108YTE sporulation protein YunB BVELS4_RS15725 ENOG4107R8B 5'-nucleotidase BVELS4_RS15735 ENOG4105I3N Conserved Protein BVELS4_RS15745 ENOG4105CD3 dihydroorotase BVELS4_RS15750 ENOG4105G9B Transcriptional regulator BVELS4_RS15775 ENOG4105C5R Aminotransferase BVELS4_RS15785 ENOG4108K8S endonuclease I BVELS4_RS15790 ENOG4108IJ9 (ABC) transporter BVELS4_RS15795 ENOG4105FDP GntR family transcriptional regulator BVELS4_RS15800 ENOG4108KPW sugar kinase BVELS4_RS15805 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BVELS4_RS15810 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BVELS4_RS15815 ENOG4105XN3 extracellular solute-binding protein family 1 BVELS4_RS15820 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BVELS4_RS15825 ENOG4108Z6Z Transcriptional regulator BVELS4_RS15850 ENOG4105PKS Excinuclease abc c subunit domain protein BVELS4_RS15855 ENOG4107VFR oxidoreductase BVELS4_RS15875 ENOG41083Q9 chitosanase BVELS4_RS15880 ENOG4105DIW FeS assembly protein SUFB BVELS4_RS15885 ENOG4108UNV SUF system FeS assembly protein, NifU family BVELS4_RS15890 ENOG4105C9B Cysteine desulfurase BVELS4_RS15895 ENOG4105JRK feS assembly protein SufD BVELS4_RS15900 ENOG4105C3K feS assembly ATPase SufC BVELS4_RS15915 ENOG4105D01 (LipO)protein BVELS4_RS15920 ENOG4108UMI ABC transporter, permease BVELS4_RS15925 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BVELS4_RS15950 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BVELS4_RS15955 ENOG41080E8 Transcriptional regulator, Spx MgsR family BVELS4_RS15960 ENOG4105C1G acyl-Coa dehydrogenase BVELS4_RS15965 ENOG4105CHU acetyl-coa acetyltransferase BVELS4_RS15995 ENOG41067TZ transcriptional regulator, MarR family BVELS4_RS16000 ENOG4105C0R drug resistance transporter emrb qaca subfamily BVELS4_RS16005 ENOG4105C5Q Transcriptional regulator BVELS4_RS16025 ENOG4105E0A ABC, transporter BVELS4_RS16040 ENOG4105E1F short-chain dehydrogenase reductase BVELS4_RS16045 ENOG4105HUF DNA protection during starvation protein BVELS4_RS16050 ENOG4105C0H protease BVELS4_RS16060 ENOG4105F3H Histidine kinase BVELS4_RS16070 ENOG41067SE Tetr family transcriptional regulator BVELS4_RS16075 ENOG4105C9Q fumarate hydratase class II BVELS4_RS16100 ENOG4105WH1 Two component transcriptional regulator luxr family BVELS4_RS16105 ENOG4105ENE Histidine kinase BVELS4_RS16120 ENOG41087YS Phage shock protein A BVELS4_RS16135 ENOG4108WBT adenosyltransferase BVELS4_RS16140 ENOG4105E0A ABC, transporter BVELS4_RS16145 ENOG4105EHG Permease protein BVELS4_RS16150 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BVELS4_RS16155 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BVELS4_RS16160 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BVELS4_RS16170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS16180 ENOG4106DF4 Sigma-70, region 4 BVELS4_RS16190 ENOG4105F0F Oxalate decarboxylase BVELS4_RS16200 ENOG4105E0A ABC, transporter BVELS4_RS16205 ENOG4105EHG Permease protein BVELS4_RS16210 ENOG4105DQ5 transport system permease protein BVELS4_RS16220 ENOG4105D5Q Arginine ornithine antiporter BVELS4_RS16230 ENOG4107K5X Membrane-bound metal-dependent hydrolase BVELS4_RS16235 ENOG4107QZ2 Sulfatase BVELS4_RS16240 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BVELS4_RS16245 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BVELS4_RS16250 ENOG4105E0C molybdate abc transporter BVELS4_RS16255 ENOG4105WH1 Two component transcriptional regulator luxr family BVELS4_RS16260 ENOG4105BZU Histidine kinase BVELS4_RS16265 ENOG4105CJ1 ABC, transporter BVELS4_RS16275 ENOG4108KYE ABC-2 type transporter BVELS4_RS16290 ENOG4105EEQ Na H antiporter BVELS4_RS16295 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BVELS4_RS16300 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BVELS4_RS16305 ENOG4105EEM helicase BVELS4_RS16310 ENOG4105EN6 Membrane BVELS4_RS16325 ENOG4107ZQN disulfide bond BVELS4_RS16330 ENOG4105C59 p-type ATPase BVELS4_RS16335 ENOG4105C59 p-type ATPase BVELS4_RS16340 ENOG410681U heavy metal transport detoxification protein BVELS4_RS16345 ENOG4105VPX protein, conserved in bacteria BVELS4_RS16350 ENOG4105D9R oxidoreductase BVELS4_RS16355 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BVELS4_RS16390 ENOG4105DEN Luciferase family BVELS4_RS16395 ENOG4105CDA abc transporter atp-binding protein BVELS4_RS16420 ENOG4108XSB acetyltransferase, (GNAT) family BVELS4_RS16425 ENOG4108KSA LysR family transcriptional regulator BVELS4_RS16430 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BVELS4_RS16435 ENOG41067XF inhibitor BVELS4_RS16445 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BVELS4_RS16450 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BVELS4_RS16460 ENOG4105XZU Preprotein translocase, subunit SecG BVELS4_RS16480 ENOG4105KVH Transcriptional regulator BVELS4_RS16505 ENOG4105DA5 (ABC) transporter BVELS4_RS16510 ENOG4105R40 Glycine betaine carnitine choline BVELS4_RS16515 ENOG4108HQR Glycine betaine BVELS4_RS16520 ENOG4105E90 ABC transporter BVELS4_RS16525 ENOG4108IJ8 ABC transporter BVELS4_RS16530 ENOG4107HG4 Transcriptional regulator BVELS4_RS16535 ENOG4105R40 Glycine betaine carnitine choline BVELS4_RS16540 ENOG4108HQR Glycine betaine BVELS4_RS16545 ENOG4105E90 ABC transporter BVELS4_RS16550 ENOG4108IJ8 ABC transporter BVELS4_RS16555 ENOG4107HG4 Transcriptional regulator BVELS4_RS16560 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BVELS4_RS16570 ENOG4105T65 Membrane-associated protein BVELS4_RS16575 ENOG4108W0I acetyltransferase BVELS4_RS16590 ENOG4105FJR Lmbe family BVELS4_RS16605 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVELS4_RS16610 ENOG4108IAJ Nad-dependent epimerase dehydratase BVELS4_RS16615 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVELS4_RS16620 ENOG4107QQG Dehydrogenase BVELS4_RS16625 ENOG4105IIU Aminopeptidase BVELS4_RS16630 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BVELS4_RS16635 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BVELS4_RS16640 ENOG4105CP7 Triose-phosphate isomerase BVELS4_RS16645 ENOG4105BZA Phosphoglycerate kinase BVELS4_RS16650 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BVELS4_RS16665 ENOG4105CMD Transcriptional regulator, GntR family BVELS4_RS16670 ENOG4105DEN Luciferase family BVELS4_RS16680 ENOG4105GZI Transcriptional regulator BVELS4_RS16685 ENOG4107RT3 EamA-like transporter family BVELS4_RS16710 ENOG410667J hydrolase BVELS4_RS16715 ENOG4106KNT transcriptional regulator BVELS4_RS16720 ENOG4105CMG Carbohydrate kinase BVELS4_RS16725 ENOG4105C6Z Gluconate BVELS4_RS16735 ENOG4107QR9 Iron-sulfur cluster binding protein BVELS4_RS16740 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BVELS4_RS16745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BVELS4_RS16750 ENOG4105JXH GntR family transcriptional regulator BVELS4_RS16755 ENOG4105DAA L-lactate BVELS4_RS16760 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BVELS4_RS16770 ENOG4108ZPC Polysaccharide pyruvyl transferase BVELS4_RS16775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVELS4_RS16780 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BVELS4_RS16785 ENOG4105D3Q Sugar transferase BVELS4_RS16795 ENOG4105K64 Glycosyl transferase, family 2 BVELS4_RS16805 ENOG4107QRS glycosyltransferase group 2 family protein BVELS4_RS16810 ENOG41068W6 Capsular polysaccharide biosynthesis protein BVELS4_RS16815 ENOG4108KMV Glycosyl transferase (Group 1 BVELS4_RS16820 ENOG4105K64 Glycosyl transferase, family 2 BVELS4_RS16825 ENOG4108PQP glycosyl transferase group 1 BVELS4_RS16835 ENOG4108QV3 biosynthesis protein BVELS4_RS16840 ENOG4105HTX biosynthesis protein BVELS4_RS16850 ENOG4105EBR Carboxylesterase BVELS4_RS16860 ENOG4105NAE bifunctional deaminase-reductase domain protein BVELS4_RS16870 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BVELS4_RS16875 ENOG4105PY6 Phenolic acid decarboxylase BVELS4_RS16880 ENOG4105NI3 Protein of unknown function (DUF3237) BVELS4_RS16920 ENOG4108HKT sucrose-6-phosphate hydrolase BVELS4_RS16925 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BVELS4_RS16930 ENOG4105ETE Transcriptional regulator (LacI family BVELS4_RS16935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BVELS4_RS16940 ENOG4108KAM Transcriptional regulator BVELS4_RS16945 ENOG4105C7F AcnD-accessory protein PrpF BVELS4_RS16955 ENOG4108URH decarboxylase BVELS4_RS16960 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BVELS4_RS16965 ENOG4105CHH sulfate transporter BVELS4_RS16970 ENOG4108V2W Carbonate dehydratase BVELS4_RS16980 ENOG4105C5I Dehydrogenase BVELS4_RS16985 ENOG4105GGE ribonuclease BVELS4_RS17000 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BVELS4_RS17005 ENOG4105KRI phosphocarrier protein (HPr BVELS4_RS17010 ENOG4105CIE May be required for sporulation (By similarity) BVELS4_RS17015 ENOG4105CHW UPF0052 protein BVELS4_RS17020 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BVELS4_RS17025 ENOG4108Z4K mutator MutT protein BVELS4_RS17030 ENOG4105C3M thioredoxin reductase BVELS4_RS17045 ENOG4105BZU Histidine kinase BVELS4_RS17050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS17055 ENOG4105BZ1 (ABC) transporter BVELS4_RS17060 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BVELS4_RS17065 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BVELS4_RS17070 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BVELS4_RS17075 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BVELS4_RS17080 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BVELS4_RS17085 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BVELS4_RS17090 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BVELS4_RS17095 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BVELS4_RS17105 ENOG4108S4C acetyltransferase BVELS4_RS17110 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BVELS4_RS17120 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BVELS4_RS17125 ENOG4105CE4 GlcNAc 6-P deacetylase BVELS4_RS17130 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BVELS4_RS17140 ENOG4105J7D transcriptional regulator BVELS4_RS17145 ENOG41088CQ domain protein BVELS4_RS17150 ENOG41086DT Membrane protein of unknown function BVELS4_RS17155 ENOG41067S9 phage shock protein C, PspC BVELS4_RS17160 ENOG4108PY7 BVELS4_RS17175 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BVELS4_RS17180 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BVELS4_RS17195 ENOG4105MKU Transcriptional regulator BVELS4_RS17215 ENOG4105CN1 protease BVELS4_RS17220 ENOG4108M26 parallel beta-helix repeat protein BVELS4_RS17225 ENOG4105CRP Part of the ABC transporter FtsEX involved in BVELS4_RS17230 ENOG4105CAK Cell division ATP-binding protein ftsE BVELS4_RS17250 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BVELS4_RS17255 ENOG4105MS2 ribosomal subunit Interface protein BVELS4_RS17270 ENOG4105MQ3 flagellar protein FliS BVELS4_RS17275 ENOG4107RT6 flagellar hook-associated BVELS4_RS17280 ENOG4105I03 Flagellin BVELS4_RS17285 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BVELS4_RS17290 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BVELS4_RS17300 ENOG4105DTJ flagellar hook-associated protein BVELS4_RS17305 ENOG4105E1Q flagellar hook-associated protein BVELS4_RS17320 ENOG4105RU3 BVELS4_RS17325 ENOG41081UC Inherit from COG: Competence protein BVELS4_RS17345 ENOG4105WH1 Two component transcriptional regulator luxr family BVELS4_RS17350 ENOG4105BZU Histidine kinase BVELS4_RS17355 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BVELS4_RS17360 ENOG4108KGH TRANSCRIPTIONal BVELS4_RS17365 ENOG4105ESV Glycosyl transferase, family 4 BVELS4_RS17370 ENOG4107EF8 Glycosyl transferase (Group 1 BVELS4_RS17385 ENOG4105QZI O-Antigen Polymerase BVELS4_RS17390 ENOG4105C6Y Udp-glucose 6-dehydrogenase BVELS4_RS17395 ENOG4107RA4 Glycosyl transferase (Group 1 BVELS4_RS17400 ENOG4105PSV Polysaccharide Biosynthesis Protein BVELS4_RS17405 ENOG4105D3Q Sugar transferase BVELS4_RS17410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BVELS4_RS17415 ENOG4105JFG SpoIID LytB domain protein BVELS4_RS17425 ENOG4108KGH TRANSCRIPTIONal BVELS4_RS17430 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BVELS4_RS17435 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BVELS4_RS17440 ENOG4105EY8 ABC transporter BVELS4_RS17450 ENOG4107SJB teichoic acid biosynthesis BVELS4_RS17455 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BVELS4_RS17460 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BVELS4_RS17470 ENOG4107RZX Teichoic acid biosynthesis protein BVELS4_RS17480 ENOG4105DG6 mannose-6-phosphate isomerase BVELS4_RS17495 ENOG4108NHD germination protein BVELS4_RS17500 ENOG4107R8N Glycosyl transferase, family 2 BVELS4_RS17505 ENOG4105C54 Major Facilitator superfamily BVELS4_RS17510 ENOG4108KGH TRANSCRIPTIONal BVELS4_RS17515 ENOG4105J7I hydrolase BVELS4_RS17525 ENOG4105K4H Nlp p60 protein BVELS4_RS17535 ENOG4105PNM synthesis protein BVELS4_RS17545 ENOG4105N98 Capsule biosynthesis protein capB BVELS4_RS17550 ENOG4105E1K spore germination protein BVELS4_RS17565 ENOG4105ETE Transcriptional regulator (LacI family BVELS4_RS17570 ENOG4108RVA ribokinase BVELS4_RS17575 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BVELS4_RS17580 ENOG4105C2J ABC transporter BVELS4_RS17585 ENOG4105CNN ABC, transporter BVELS4_RS17590 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BVELS4_RS17600 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BVELS4_RS17605 ENOG4107FQX Alpha-acetolactate decarboxylase BVELS4_RS17615 ENOG4107RSM transcriptional regulator BVELS4_RS17630 ENOG4106UIA BVELS4_RS17645 ENOG4107XC4 flavin reductase domain protein, FMN-binding BVELS4_RS17655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BVELS4_RS17665 ENOG4105CAH Chromate BVELS4_RS17670 ENOG4105FGV Chromate BVELS4_RS17675 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BVELS4_RS17700 ENOG4108XI2 Domain of unknown function (DUF1963) BVELS4_RS17705 ENOG4105C6Y Udp-glucose 6-dehydrogenase BVELS4_RS17710 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BVELS4_RS17715 ENOG4107YJ4 chain length determinant protein BVELS4_RS17720 ENOG4105HTX biosynthesis protein BVELS4_RS17730 ENOG4105KBK Zinc finger, swim domain protein BVELS4_RS17735 ENOG4105C0D helicase BVELS4_RS17740 ENOG410667J hydrolase BVELS4_RS17745 ENOG4105E98 transcriptional regulator DeoR family BVELS4_RS17750 ENOG4105Z8H single-stranded DNA-binding protein BVELS4_RS17765 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BVELS4_RS17770 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BVELS4_RS17780 ENOG4105CGA flagellar basal-body rod protein FlgG BVELS4_RS17790 ENOG4105DFF Rod shape-determining protein mreb BVELS4_RS17795 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BVELS4_RS17800 ENOG4107MII Sugar-specific transcriptional regulator TrmB BVELS4_RS17805 ENOG4105CZM Major Facilitator BVELS4_RS17810 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BVELS4_RS17815 ENOG41080V3 Major Facilitator superfamily BVELS4_RS17820 ENOG4105D3W isochorismatase BVELS4_RS17825 ENOG4105BZU Histidine kinase BVELS4_RS17835 ENOG4105CNI cell division protein FtsW BVELS4_RS17840 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BVELS4_RS17850 ENOG4105FRN stage II sporulation protein BVELS4_RS17855 ENOG4107TCE N-acetyltransferase BVELS4_RS17870 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BVELS4_RS17875 ENOG4106BRK BVELS4_RS17880 ENOG4107T94 Endo-14-beta-xylanase BVELS4_RS17885 ENOG4108Z40 Transcriptional regulator BVELS4_RS17890 ENOG4105CQM Urea amidohydrolase subunit alpha BVELS4_RS17895 ENOG4105KI2 Urea amidohydrolase subunit beta BVELS4_RS17900 ENOG4108YZ9 Urea amidohydrolase subunit gamma BVELS4_RS17920 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BVELS4_RS17925 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BVELS4_RS17935 ENOG4108TF4 von Willebrand factor, type A BVELS4_RS17950 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BVELS4_RS17960 ENOG4106778 Protein of unknown function (DUF1146) BVELS4_RS17970 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BVELS4_RS17975 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BVELS4_RS17980 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BVELS4_RS17985 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BVELS4_RS17990 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BVELS4_RS18005 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BVELS4_RS18015 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BVELS4_RS18020 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BVELS4_RS18025 ENOG4108UIC UPF0340 protein BVELS4_RS18030 ENOG4108YZG isomerase BVELS4_RS18035 ENOG4107WAU Protein tyrosine phosphatase BVELS4_RS18040 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BVELS4_RS18045 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BVELS4_RS18055 ENOG4108ZXQ stage ii sporulation protein r BVELS4_RS18070 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BVELS4_RS18075 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BVELS4_RS18080 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BVELS4_RS18090 ENOG4107TT2 Auxin Efflux Carrier BVELS4_RS18095 ENOG4105C6K Malic enzyme BVELS4_RS18100 ENOG4107104 thymidine kinase BVELS4_RS18110 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BVELS4_RS18115 ENOG4105CBT Fructose-1,6-bisphosphatase BVELS4_RS18120 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BVELS4_RS18130 ENOG4105D2N Aldolase BVELS4_RS18135 ENOG410812K response regulator receiver protein BVELS4_RS18145 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BVELS4_RS18155 ENOG4105DF6 Fe-S oxidoreductase BVELS4_RS18165 ENOG4105E5J UV damage endonuclease BVELS4_RS18175 ENOG4105BZ1 (ABC) transporter BVELS4_RS18180 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BVELS4_RS18195 ENOG4105R3A Nitrate reductase BVELS4_RS18200 ENOG4108IUE nitrate reductase beta subunit BVELS4_RS18220 ENOG4107V6Q Cyclic nucleotide-binding domain BVELS4_RS18230 ENOG4105C75 arginyL-tRNA synthetase BVELS4_RS18235 ENOG410684U Domain of unknown function (DUF1934) BVELS4_RS18255 ENOG4107JM4 Tetratricopeptide repeat BVELS4_RS18300 ENOG4105CYW agmatinase BVELS4_RS18305 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BVELS4_RS18310 ENOG4105BZ4 penicillin-binding protein BVELS4_RS18320 ENOG4108XFG YwhD family BVELS4_RS18325 ENOG4108Z4T Peptidase M50 BVELS4_RS18330 ENOG41069HH 4-oxalocrotonate tautomerase BVELS4_RS18335 ENOG41067TZ transcriptional regulator, MarR family BVELS4_RS18340 ENOG4105CUB amino acid BVELS4_RS18350 ENOG4105DCI Phosphohydrolase BVELS4_RS18360 ENOG4108VCI transcription factor, rsfa family BVELS4_RS18365 ENOG4105K7K Transcriptional regulator BVELS4_RS18375 ENOG4105CJ1 ABC, transporter BVELS4_RS18380 ENOG4108TU7 Inherit from COG: (ABC) transporter BVELS4_RS18405 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BVELS4_RS18410 ENOG4105DUM transcriptional regulator, lysR family BVELS4_RS18415 ENOG4105HMI Membrane BVELS4_RS18420 ENOG4108IJ2 phosphate acetyltransferase BVELS4_RS18425 ENOG4107JTW chlorite dismutase BVELS4_RS18435 ENOG4105CHM Aminotransferase BVELS4_RS18465 ENOG4105FCW Major Facilitator superfamily BVELS4_RS18470 ENOG4105C2C drug resistance transporter, Bcr CflA BVELS4_RS18485 ENOG4105C26 Dehydrogenase BVELS4_RS18490 ENOG4105D82 Glutamate dehydrogenase BVELS4_RS18500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS18520 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BVELS4_RS18525 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BVELS4_RS18530 ENOG4105C1B dTDP-glucose 4-6-dehydratase BVELS4_RS18535 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BVELS4_RS18540 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BVELS4_RS18545 ENOG4107TY6 Acylneuraminate cytidylyltransferase BVELS4_RS18555 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BVELS4_RS18560 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BVELS4_RS18595 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BVELS4_RS18600 ENOG4108RJ9 Glycosyl transferase, family 2 BVELS4_RS18620 ENOG4105DWF phosphomethylpyrimidine kinase BVELS4_RS18635 ENOG4105C5Y PTS System BVELS4_RS18650 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BVELS4_RS18655 ENOG4105DEN Luciferase family BVELS4_RS18665 ENOG4108DBC nitroreductase BVELS4_RS18675 ENOG4105I4A GCN5-related N-acetyltransferase BVELS4_RS18695 ENOG4105BZ9 Cytochrome C oxidase, subunit I BVELS4_RS18700 ENOG4105E2S oxidase) subunit II BVELS4_RS18705 ENOG4107BMA Transglycosylase associated protein BVELS4_RS18715 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BVELS4_RS18720 ENOG4105WH5 Teichoic acid glycosylation protein BVELS4_RS18745 ENOG4107ZXU DSBA oxidoreductase BVELS4_RS18750 ENOG4105DBE peroxidase BVELS4_RS18755 ENOG410650H (LipO)protein BVELS4_RS18760 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BVELS4_RS18765 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BVELS4_RS18770 ENOG4105CMU LysR family (Transcriptional regulator BVELS4_RS18775 ENOG4105VAW lrga family BVELS4_RS18780 ENOG41067MG lrgb family BVELS4_RS18790 ENOG4107TXC Transcriptional regulator BVELS4_RS18800 ENOG4105DR4 Methyltransferase BVELS4_RS18810 ENOG4105CK1 PTS System BVELS4_RS18815 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BVELS4_RS18820 ENOG4105X1N Glycosyl transferase family 8 BVELS4_RS18830 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BVELS4_RS18840 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BVELS4_RS18845 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BVELS4_RS18850 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BVELS4_RS18855 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BVELS4_RS18860 ENOG4105CM2 brancheD-chain amino acid aminotransferase BVELS4_RS18865 ENOG4105F8D glycoside hydrolase family 4 BVELS4_RS18870 ENOG4105VCP PTS System BVELS4_RS18875 ENOG4105CK1 PTS System BVELS4_RS18880 ENOG4105VZJ PTS System BVELS4_RS18885 ENOG4105EMD TRANSCRIPTIONal BVELS4_RS18895 ENOG4105DQ5 transport system permease protein BVELS4_RS18900 ENOG4105EHG Permease protein BVELS4_RS18910 ENOG41082YX Transcriptional regulator, arsr family BVELS4_RS18915 ENOG4107R5R arsenical pump membrane protein BVELS4_RS18920 ENOG4105VZJ PTS System BVELS4_RS18925 ENOG4105VCP PTS System BVELS4_RS18930 ENOG4105CK1 PTS System BVELS4_RS18935 ENOG4105CS2 ec 3.2.1.21 BVELS4_RS18940 ENOG4105EVU fructokinase BVELS4_RS18945 ENOG4105DG6 mannose-6-phosphate isomerase BVELS4_RS18955 ENOG4105CH6 catalase BVELS4_RS18960 ENOG4107QHE Choloylglycine hydrolase BVELS4_RS18965 ENOG4105ETS cytosine purines uracil thiamine allantoin BVELS4_RS18970 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BVELS4_RS18975 ENOG4108JJ8 (ABC) transporter BVELS4_RS18980 ENOG4108JJ9 ABC, transporter BVELS4_RS18985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BVELS4_RS18990 ENOG4105C4M (Ubiquinol oxidase) subunit I BVELS4_RS18995 ENOG4105D2K citrate carrier protein BVELS4_RS19000 ENOG4107BJW polysaccharide deacetylase BVELS4_RS19015 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BVELS4_RS19025 ENOG4105CMR udp-glucose 4-epimerase BVELS4_RS19030 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BVELS4_RS19050 ENOG4105DHI Methyltransferase BVELS4_RS19070 ENOG4105CH6 catalase BVELS4_RS19075 ENOG4105D4T Citrate transporter BVELS4_RS19085 ENOG4105CID antiterminator BVELS4_RS19090 ENOG4105DEU major facilitator superfamily BVELS4_RS19095 ENOG4105C1J atp-dependent rna helicase BVELS4_RS19175 ENOG4105CNA YD repeat protein BVELS4_RS19180 ENOG4108NR7 pectate lyase BVELS4_RS19190 ENOG4107YZX Universal stress protein BVELS4_RS19195 ENOG4105CS2 ec 3.2.1.21 BVELS4_RS19200 ENOG4105C5Y PTS System BVELS4_RS19215 ENOG4106Z5D Glycoside Hydrolase Family 43 BVELS4_RS19225 ENOG4105C84 Histidine ammonia-lyase BVELS4_RS19230 ENOG4105CGP Urocanate hydratase BVELS4_RS19235 ENOG4105CI2 imidazolone-5-propionate hydrolase BVELS4_RS19240 ENOG4107W25 arginase agmatinase formiminoglutamase BVELS4_RS19255 ENOG4105D9N nucleoside BVELS4_RS19260 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BVELS4_RS19265 ENOG4107RHR regulatoR BVELS4_RS19270 ENOG410667J hydrolase BVELS4_RS19300 ENOG4108V5C ABC transporter BVELS4_RS19335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS19360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BVELS4_RS19385 ENOG4105WZ4 isomerase BVELS4_RS19390 ENOG4105F0H myo-inositol catabolism protein BVELS4_RS19395 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BVELS4_RS19405 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BVELS4_RS19415 ENOG4105EDK PfkB domain protein BVELS4_RS19425 ENOG4105C26 Dehydrogenase BVELS4_RS19435 ENOG4105CPC Aldo Keto reductase BVELS4_RS19440 ENOG4107QNK )-transporter BVELS4_RS19445 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BVELS4_RS19455 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BVELS4_RS19460 ENOG4108S01 response regulator BVELS4_RS19465 ENOG4108ZGX Histidine kinase BVELS4_RS19470 ENOG4105ECK Fatty Acid Desaturase BVELS4_RS19475 ENOG4105ST3 Transcriptional regulator BVELS4_RS19480 ENOG4105C26 Dehydrogenase BVELS4_RS19485 ENOG4108ITS PQQ enzyme repeat BVELS4_RS19495 ENOG4105WAB arsR family transcriptional regulator BVELS4_RS19500 ENOG4105F27 Major Facilitator BVELS4_RS19505 ENOG41085PJ rdd domain containing protein BVELS4_RS19515 ENOG4105D0M Protease HtpX homolog BVELS4_RS19520 ENOG4106H3A restriction BVELS4_RS19525 ENOG4105D3R alkyl hydroperoxide reductase BVELS4_RS19530 ENOG4108JU3 Alkyl hydroperoxide reductase BVELS4_RS19535 ENOG4107R3N Filamentation induced by cAMP protein fic BVELS4_RS19540 ENOG4105C85 amino acid BVELS4_RS19545 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BVELS4_RS19550 ENOG4108XHQ (2Fe-2S)-binding domain protein BVELS4_RS19570 ENOG4105XRQ Xanthine dehydrogenase accessory factor BVELS4_RS19590 ENOG4105DVF Cytosine-specific methyltransferase BVELS4_RS19615 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BVELS4_RS19635 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BVELS4_RS19640 ENOG4105CPC Aldo Keto reductase BVELS4_RS19645 ENOG4105WQG acetyltransferase BVELS4_RS19655 ENOG41066UZ arginase EC 3.5.3.1 BVELS4_RS19660 ENOG4108IQI permease BVELS4_RS19665 ENOG4105C8Y Acetylornithine aminotransferase BVELS4_RS19675 ENOG41082BM Transcriptional regulator, arsr family BVELS4_RS19680 ENOG4108JUB Transcriptional regulator BVELS4_RS19690 ENOG4105C5H ABC transporter BVELS4_RS19705 ENOG4105D06 uba thif-type nad fad binding protein BVELS4_RS19710 ENOG41062D9 Histidine kinase BVELS4_RS19715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS19720 ENOG4105C0H protease BVELS4_RS19725 ENOG4105Q2H domain protein BVELS4_RS19740 ENOG4105BZU Histidine kinase BVELS4_RS19745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BVELS4_RS19770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BVELS4_RS19775 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BVELS4_RS19780 ENOG4105CDU Replicative dna helicase BVELS4_RS19800 ENOG4105EDW glycosyl transferase, family 39 BVELS4_RS19815 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BVELS4_RS19820 ENOG4105CPK Glycosyl transferase (Group 1 BVELS4_RS19840 ENOG4105BZR domain protein BVELS4_RS19845 ENOG4108XMW Membrane BVELS4_RS19860 ENOG4105KVH Transcriptional regulator BVELS4_RS19865 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BVELS4_RS19870 ENOG4108UZ3 Transporter BVELS4_RS19875 ENOG4105EDQ levansucrase EC 2.4.1.10 BVELS4_RS19880 ENOG4108HKT sucrose-6-phosphate hydrolase BVELS4_RS19885 ENOG4107XBN GntR Family Transcriptional Regulator BVELS4_RS19900 ENOG4107V2S Transcriptional regulator BVELS4_RS19905 ENOG4108VP3 Lysine exporter protein (LysE YggA) BVELS4_RS19910 ENOG4105D94 Major Facilitator Superfamily BVELS4_RS19915 ENOG4107RSM transcriptional regulator BVELS4_RS19925 ENOG4108TVJ Nitroreductase BVELS4_RS19930 ENOG4105FS7 Transcriptional regulator BVELS4_RS19940 ENOG4108U05 Transcriptional regulator BVELS4_RS19945 ENOG41082BV acetyltransferase BVELS4_RS19955 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BVELS4_RS19960 ENOG4105CMU LysR family (Transcriptional regulator BVELS4_RS19965 ENOG4105DTD Dehydrogenase BVELS4_RS19975 ENOG4107Y9U Membrane BVELS4_RS19980 ENOG4105C7Z Conserved Protein BVELS4_RS19985 ENOG4107FCW Abortive infection protein BVELS4_RS19995 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BVELS4_RS20005 ENOG4105CGK Exodeoxyribonuclease III BVELS4_RS20010 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BVELS4_RS20020 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BVELS4_RS20025 ENOG4108UUM single-stranded DNA-binding protein BVELS4_RS20030 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BVELS4_RS20035 ENOG4105C3G gtp-binding protein BVELS4_RS20040 ENOG4108J2R molybdopterin oxidoreductase BVELS4_RS20045 ENOG4105VDK protein, conserved in bacteria BVELS4_RS20060 ENOG4108ZDA Sporulation protein YyaC BVELS4_RS20065 ENOG4105FA0 parb-like partition protein BVELS4_RS20070 ENOG4107QJE Chromosome Partitioning Protein BVELS4_RS20085 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BVELS4_RS20090 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BVELS4_RS20105 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)