locus-tag class description DXY21_RS00010 ENOG4105CUB amino acid DXY21_RS00015 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY21_RS00020 ENOG4105BZN citrate synthase DXY21_RS00035 ENOG4105G6Z alkaline phosphatase DXY21_RS00040 ENOG4105ED1 spovr family DXY21_RS00075 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS00080 ENOG4105BZU Histidine kinase DXY21_RS00090 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DXY21_RS00095 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DXY21_RS00105 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DXY21_RS00110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY21_RS00115 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXY21_RS00120 ENOG4107YBY Hydrolase DXY21_RS00125 ENOG41080XP Cbs domain DXY21_RS00135 ENOG4108YBP pseudouridine synthase DXY21_RS00185 ENOG4105VEQ Cold shock protein DXY21_RS00190 ENOG4108TU7 Inherit from COG: (ABC) transporter DXY21_RS00195 ENOG4105CJ1 ABC, transporter DXY21_RS00200 ENOG4105CZV ABC transporter DXY21_RS00205 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DXY21_RS00220 ENOG4105CS1 NAD(P)H quinone oxidoreductase DXY21_RS00225 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY21_RS00230 ENOG4105CW7 secretion protein, HlyD family DXY21_RS00235 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DXY21_RS00245 ENOG4105CYN Serine protein kinase DXY21_RS00265 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DXY21_RS00275 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DXY21_RS00290 ENOG4105VZ8 Transcriptional regulator DXY21_RS00295 ENOG4107D63 DXY21_RS00300 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DXY21_RS00310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DXY21_RS00315 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DXY21_RS00320 ENOG4105E2Y ABC, transporter DXY21_RS00335 ENOG4108JQ7 (ABC) transporter DXY21_RS00340 ENOG4105C3U ABC transporter DXY21_RS00345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY21_RS00355 ENOG4105DEF Extracellular solute-binding protein, family 5 DXY21_RS00365 ENOG4105DNP FAD linked oxidase domain protein DXY21_RS00370 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DXY21_RS00375 ENOG4105EC3 peptidase S51, dipeptidase E DXY21_RS00485 ENOG4105TUA UPF0295 protein DXY21_RS00490 ENOG4105G5W regulator Fur family DXY21_RS00495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY21_RS00500 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DXY21_RS00505 ENOG4107NBY Membrane DXY21_RS00510 ENOG4105BZ1 (ABC) transporter DXY21_RS00530 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DXY21_RS00535 ENOG4106BXE DXY21_RS00540 ENOG4105CEN a g-specific adenine glycosylase DXY21_RS00545 ENOG41067AE Membrane-bound metal-dependent hydrolase DXY21_RS00550 ENOG4105EJV Membrane DXY21_RS00555 ENOG4105CKK Glycosyl transferase, family 2 DXY21_RS00560 ENOG4105D74 hydrolase DXY21_RS00565 ENOG4106AKJ DXY21_RS00585 ENOG4108TCS Glutamyl endopeptidase DXY21_RS00595 ENOG4105F27 Major Facilitator DXY21_RS00605 ENOG410902V Modulates RecA activity (By similarity) DXY21_RS00610 ENOG4105ECP epimerase DXY21_RS00625 ENOG4107Y03 Nitroreductase DXY21_RS00630 ENOG4105JAB phenazine biosynthesis protein, phzf family DXY21_RS00640 ENOG410834F Transcriptional regulator DXY21_RS00645 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY21_RS00650 ENOG4108YYS metal-dependent hydrolase (By similarity) DXY21_RS00665 ENOG4105H93 Acyltransferase family DXY21_RS00670 ENOG4105DYS nad(p)h dehydrogenase (quinone) DXY21_RS00675 ENOG4105U3E Transcriptional regulator DXY21_RS00680 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXY21_RS00685 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DXY21_RS00695 ENOG4105BZ1 (ABC) transporter DXY21_RS00700 ENOG4105BZ1 (ABC) transporter DXY21_RS00705 ENOG4105CI1 PTS System DXY21_RS00710 ENOG4108Q3X Transcriptional regulator DXY21_RS00715 ENOG4105F8D glycoside hydrolase family 4 DXY21_RS00725 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DXY21_RS00735 ENOG4107QKR Dehydrogenase DXY21_RS00745 ENOG4107RUY (E1 component), alpha subunit DXY21_RS00765 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXY21_RS00775 ENOG4105D7N magnesium and cobalt transport protein CorA DXY21_RS00785 ENOG4106KE4 Dehydrogenase DXY21_RS00805 ENOG4105D8X mechanosensitive ion channel DXY21_RS00815 ENOG4105UPD Calcium Proton DXY21_RS00820 ENOG4108ISG Major Facilitator DXY21_RS00825 ENOG4107U9T Pfam:Ribonuclease_BN DXY21_RS00835 ENOG4105KJF protein tyrosine phosphatase DXY21_RS00850 ENOG4105FF2 Type I DHQase DXY21_RS00855 ENOG4105E2X shikimate dehydrogenase DXY21_RS00860 ENOG4105ETE Transcriptional regulator (LacI family DXY21_RS00865 ENOG4107RKG DJ-1/PfpI family DXY21_RS00870 ENOG4105CGH 5'-nucleotidase DXY21_RS00885 ENOG4108RCM Nitroreductase DXY21_RS00890 ENOG4107414 GntR family transcriptional regulator DXY21_RS00895 ENOG4105CG3 alpha amylase, catalytic region DXY21_RS00900 ENOG4105C5Y PTS System DXY21_RS00940 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DXY21_RS00960 ENOG4108RPX mosc domain containing protein DXY21_RS00965 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) DXY21_RS00990 ENOG4108MRH transcriptional regulatory protein DXY21_RS01000 ENOG4108Z6X (sortase) family DXY21_RS01010 ENOG4108VAC response regulator DXY21_RS01035 ENOG4107QPK )-transporter DXY21_RS01040 ENOG4108J20 pectate lyase DXY21_RS01055 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DXY21_RS01065 ENOG4105FDU atp-dependent rna helicase DXY21_RS01070 ENOG4105C5H ABC transporter DXY21_RS01075 ENOG4105DXB Major Facilitator superfamily DXY21_RS01080 ENOG4107SWG transcriptional regulator MERR family DXY21_RS01085 ENOG4105C5H ABC transporter DXY21_RS01090 ENOG4107TVC Glycosyl transferase, family 2 DXY21_RS01095 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY21_RS01100 ENOG4105FKZ Methyl-accepting chemotaxis DXY21_RS01105 ENOG4105C26 Dehydrogenase DXY21_RS01110 ENOG4105CUB amino acid DXY21_RS01115 ENOG4105EU0 Major facilitator Superfamily DXY21_RS01120 ENOG41090R9 glycosyltransferase DXY21_RS01125 ENOG4107R51 Glycosyl transferase, family 2 DXY21_RS01130 ENOG41090R9 glycosyltransferase DXY21_RS01140 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DXY21_RS01145 ENOG4105E0M Sulfatase DXY21_RS01150 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY21_RS01155 ENOG4108R1P DXY21_RS01160 ENOG41061H0 Monooxygenase DXY21_RS01165 ENOG41082F9 transcriptional regulator DXY21_RS01175 ENOG4106I4J membrane DXY21_RS01195 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DXY21_RS01200 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DXY21_RS01205 ENOG4105H67 Protein of unknown function (DUF421) DXY21_RS01215 ENOG4105M18 -acetyltransferase DXY21_RS01220 ENOG4105WEF catalase DXY21_RS01235 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DXY21_RS01245 ENOG4105CDY transcriptional regulatory protein DXY21_RS01280 ENOG4105CJ1 ABC, transporter DXY21_RS01290 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXY21_RS01295 ENOG4105CBD Diacylglycerol kinase DXY21_RS01305 ENOG4108IG5 Transcriptional regulator DXY21_RS01310 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXY21_RS01315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DXY21_RS01320 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXY21_RS01325 ENOG4105CK7 Sodium proline symporter DXY21_RS01330 ENOG4105KT7 mgtC SapB transporter DXY21_RS01335 ENOG4105CRN Aminoglycoside phosphotransferase DXY21_RS01345 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DXY21_RS01350 ENOG4105C4R Atp-dependent dna helicase DXY21_RS01365 ENOG4105CBC glutamate synthase DXY21_RS01370 ENOG4105KGF protein, YerC YecD DXY21_RS01375 ENOG4108R5T secreted protein DXY21_RS01390 ENOG4105C12 Phosphoribosylglycinamide synthetase DXY21_RS01395 ENOG4105DC1 bifunctional purine biosynthesis protein purh DXY21_RS01400 ENOG4108V3E phosphoribosylglycinamide formyltransferase DXY21_RS01405 ENOG4105CXB phosphoribosylaminoimidazole synthetase DXY21_RS01415 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DXY21_RS01420 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DXY21_RS01425 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DXY21_RS01430 ENOG4105C8V SAICAR synthetase DXY21_RS01435 ENOG4105C83 adenylosuccinate lyase DXY21_RS01440 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DXY21_RS01445 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DXY21_RS01470 ENOG4105C7N Xanthine uracil vitamin C permease DXY21_RS01485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DXY21_RS01500 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DXY21_RS01505 ENOG4105C85 amino acid DXY21_RS01510 ENOG4107STQ Multicopper oxidase DXY21_RS01535 ENOG4105JVQ RNA Polymerase DXY21_RS01540 ENOG4108P49 AntiSigma factor DXY21_RS01545 ENOG4105EXC Acyl-transferase DXY21_RS01555 ENOG4108WV1 Pfam:DUF477 DXY21_RS01560 ENOG4105DQX Zinc finger domain DXY21_RS01565 ENOG41087YS Phage shock protein A DXY21_RS01580 ENOG4105CT4 transporter DXY21_RS01585 ENOG4105CPQ Dehydrogenase DXY21_RS01590 ENOG4105PGZ NB-ARC domain DXY21_RS01595 ENOG4105KCT ABC transporter DXY21_RS01600 ENOG4108M15 ABC transporter DXY21_RS01650 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DXY21_RS01655 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DXY21_RS01660 ENOG4108TYN CAAX amino terminal protease family protein DXY21_RS01670 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXY21_RS01675 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXY21_RS01680 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DXY21_RS01685 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DXY21_RS01690 ENOG4105C5H ABC transporter DXY21_RS01695 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXY21_RS01700 ENOG410801F ribosomal-protein-alanine acetyltransferase DXY21_RS01705 ENOG41072GX Peptidase M22 Glycoprotease DXY21_RS01710 ENOG4105K8N protein family UPF0079, ATPase DXY21_RS01715 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DXY21_RS01755 ENOG4107QNK )-transporter DXY21_RS01775 ENOG4107QTZ amino acid DXY21_RS01795 ENOG4105DJ2 Major Facilitator Superfamily DXY21_RS01800 ENOG4105JXH GntR family transcriptional regulator DXY21_RS01805 ENOG4108TZY GntR Family Transcriptional Regulator DXY21_RS01810 ENOG4108SUT Major Facilitator Superfamily DXY21_RS01815 ENOG41090UD (LipO)protein DXY21_RS01820 ENOG4105FQP Beta-lactamase DXY21_RS01840 ENOG4105DRR Transcriptional regulator, GntR family DXY21_RS01845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXY21_RS01850 ENOG4105F2W methyltransferase DXY21_RS01865 ENOG41090E6 transcriptional regulator MERR family DXY21_RS01885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DXY21_RS01890 ENOG4105C2C drug resistance transporter, Bcr CflA DXY21_RS01900 ENOG4108JYZ YitT family DXY21_RS01920 ENOG4105EYF MMPL domain protein DXY21_RS01925 ENOG4108VB1 regulatoR DXY21_RS01930 ENOG4105ENE Histidine kinase DXY21_RS01940 ENOG4105PGS Spore coat protein DXY21_RS01945 ENOG4105E2A Dehydrogenase DXY21_RS01960 ENOG4108JGH Tetr family transcriptional regulator DXY21_RS01965 ENOG4105EQ0 Major Facilitator superfamily DXY21_RS01980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXY21_RS01990 ENOG4105VUF Transcriptional regulator DXY21_RS01995 ENOG4105DQ4 alcohol dehydrogenase DXY21_RS02020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DXY21_RS02035 ENOG4105H3G oxidoreductase DXY21_RS02040 ENOG4105PGM cation diffusion facilitator family transporter DXY21_RS02050 ENOG4105DNP FAD linked oxidase domain protein DXY21_RS02070 ENOG4105DXI Major Facilitator superfamily DXY21_RS02075 ENOG4107U9B transcriptional regulator DXY21_RS02080 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DXY21_RS02085 ENOG4108MCI Transcriptional regulator, ARAC family DXY21_RS02090 ENOG4105CH2 amidohydrolase DXY21_RS02095 ENOG4105C44 Serine transporter DXY21_RS02100 ENOG4105KME endoribonuclease L-psp DXY21_RS02105 ENOG4108WYP Transcriptional regulator DXY21_RS02110 ENOG4107RCH Diaminopropionate ammonia-lyase DXY21_RS02120 ENOG4105IRW patatin-like phospholipase family protein DXY21_RS02140 ENOG41087NI Sulfite exporter TauE/SafE DXY21_RS02145 ENOG4105VFE sira family DXY21_RS02150 ENOG4107TPS domain protein DXY21_RS02155 ENOG4105VFE sira family DXY21_RS02165 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DXY21_RS02170 ENOG4105XTG Pfam:DUF156 DXY21_RS02180 ENOG4105VEQ Cold shock protein DXY21_RS02185 ENOG4108RYK Nad-dependent epimerase dehydratase DXY21_RS02190 ENOG4108Z40 Transcriptional regulator DXY21_RS02200 ENOG4105K56 Transcriptional regulator DXY21_RS02205 ENOG4108ZHJ Organic hydroperoxide resistance protein DXY21_RS02215 ENOG4105CSH Transporter DXY21_RS02220 ENOG4105C94 Transporter DXY21_RS02305 ENOG410906U SprT-like DXY21_RS02320 ENOG41064BQ Phosphatase DXY21_RS02330 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXY21_RS02335 ENOG4105WN5 stage II sporulation protein DXY21_RS02340 ENOG4107SGM protein serine threonine phosphatase DXY21_RS02345 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DXY21_RS02350 ENOG4105FUA antagonist DXY21_RS02355 ENOG4107MMM Anti-sigma-factor antagonist DXY21_RS02360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DXY21_RS02370 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXY21_RS02375 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DXY21_RS02380 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DXY21_RS02390 ENOG4105CKV Membrane DXY21_RS02395 ENOG410905X membrane-flanked domain protein DXY21_RS02400 ENOG4105C1J atp-dependent rna helicase DXY21_RS02405 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DXY21_RS02410 ENOG4105CPF Cell wall formation (By similarity) DXY21_RS02415 ENOG4105SZ6 Thioredoxin DXY21_RS02435 ENOG4105FDT acyl-CoA dehydrogenase DXY21_RS02450 ENOG4105CJ1 ABC, transporter DXY21_RS02455 ENOG4106F5Q Membrane DXY21_RS02460 ENOG4107QJT sodium dicarboxylate symporter DXY21_RS02465 ENOG4108MRH transcriptional regulatory protein DXY21_RS02470 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DXY21_RS02475 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DXY21_RS02490 ENOG41082W1 Cupin 2, conserved barrel domain protein DXY21_RS02495 ENOG4105QVS general stress protein DXY21_RS02500 ENOG4105EU9 DXY21_RS02505 ENOG4105KPY Small multidrug resistance protein DXY21_RS02510 ENOG4105RXJ DXY21_RS02515 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DXY21_RS02525 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DXY21_RS02570 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXY21_RS02610 ENOG4105C0X amino acid DXY21_RS02620 ENOG4107R8N Glycosyl transferase, family 2 DXY21_RS02625 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DXY21_RS02640 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY21_RS02650 ENOG4105VCH membrane DXY21_RS02660 ENOG410606W general stress protein DXY21_RS02675 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY21_RS02685 ENOG4105ETD TRANSCRIPTIONal DXY21_RS02690 ENOG4107QM2 Aldo Keto reductase DXY21_RS02695 ENOG4107RVG penicillin-binding protein DXY21_RS02700 ENOG41061CK Antibiotic biosynthesis monooxygenase DXY21_RS02710 ENOG4105XJB lipolytic protein G-D-S-L family DXY21_RS02715 ENOG4107258 Transcriptional regulator DXY21_RS02725 ENOG4105P4J Allophanate hydrolase, subunit 1 DXY21_RS02730 ENOG4105CFM UPF0317 protein DXY21_RS02735 ENOG4105C5A transporter DXY21_RS02740 ENOG4105E7W lamb ycsf family protein DXY21_RS02760 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DXY21_RS02780 ENOG4108ZYE Transcriptional regulator DXY21_RS02785 ENOG4108T5E Copper resistance protein DXY21_RS02790 ENOG4105KTB nuclear export factor GLE1 DXY21_RS02795 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXY21_RS02805 ENOG4105C26 Dehydrogenase DXY21_RS02810 ENOG4108JPW Aminotransferase DXY21_RS02820 ENOG4105YVS arsR family transcriptional regulator DXY21_RS02825 ENOG41067V3 Antibiotic biosynthesis monooxygenase DXY21_RS02830 ENOG4108DBC nitroreductase DXY21_RS02835 ENOG4105R8C Transcriptional regulator DXY21_RS02850 ENOG4108IPW abc transporter atp-binding protein DXY21_RS02855 ENOG4105CM4 permease protein DXY21_RS02860 ENOG4105DHS permease protein DXY21_RS02865 ENOG4105CFH Aspartokinase DXY21_RS02885 ENOG4105BZU Histidine kinase DXY21_RS02890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY21_RS02895 ENOG4107WD8 ABC transporter, permease DXY21_RS02905 ENOG4108PGP mmge prpd family protein DXY21_RS02910 ENOG4105CH2 amidohydrolase DXY21_RS02920 ENOG4108HW4 amino acid AbC transporter DXY21_RS02925 ENOG4105EAB amino acid AbC transporter DXY21_RS02930 ENOG4108XSB acetyltransferase, (GNAT) family DXY21_RS02935 ENOG4105CPU Monooxygenase DXY21_RS02950 ENOG4105E1K spore germination protein DXY21_RS02965 ENOG4105DUX Transporter DXY21_RS02970 ENOG41069ZX DXY21_RS02975 ENOG41069ZX DXY21_RS02980 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DXY21_RS02985 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DXY21_RS02990 ENOG4106P55 Transcriptional regulator DXY21_RS03000 ENOG4105DRP amino acid AbC transporter DXY21_RS03005 ENOG4105CDA abc transporter atp-binding protein DXY21_RS03020 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DXY21_RS03040 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS03045 ENOG4105KVH Transcriptional regulator DXY21_RS03050 ENOG4108VA3 3-hexulose-6-phosphate synthase DXY21_RS03055 ENOG41080HJ 6-phospho 3-hexuloisomerase DXY21_RS03075 ENOG4105CS2 ec 3.2.1.21 DXY21_RS03085 ENOG4105HHM rdd domain containing protein DXY21_RS03090 ENOG4105E2A Dehydrogenase DXY21_RS03095 ENOG4105CKI cobalamin synthesis protein DXY21_RS03100 ENOG4108IFG nitrite reductase, (NAD(P)H) DXY21_RS03105 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DXY21_RS03110 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXY21_RS03115 ENOG4105CAY ferredoxin--nadp reductase DXY21_RS03120 ENOG4107YHD transcriptional regulator DXY21_RS03125 ENOG4105CK7 Sodium proline symporter DXY21_RS03130 ENOG4105C26 Dehydrogenase DXY21_RS03140 ENOG410756H nucleotidyltransferase DXY21_RS03145 ENOG4105I82 acetyl xylan esterase DXY21_RS03150 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DXY21_RS03155 ENOG4105DJB Major Facilitator Superfamily DXY21_RS03165 ENOG4105I1F Resistance protein DXY21_RS03175 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DXY21_RS03180 ENOG4105EIG urea carboxylase-associated protein 1 DXY21_RS03210 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DXY21_RS03240 ENOG4107SQ8 Glycine betaine DXY21_RS03245 ENOG4108IJ7 Glycine betaine DXY21_RS03250 ENOG41079KZ Major Facilitator Superfamily DXY21_RS03260 ENOG4108TTB tellurium resistance protein DXY21_RS03265 ENOG4107TS3 membrane protein, TerC DXY21_RS03270 ENOG4106FN3 tellurium resistance protein DXY21_RS03275 ENOG4106FN3 tellurium resistance protein DXY21_RS03280 ENOG4108N0M stress protein DXY21_RS03285 ENOG4105DEN Luciferase family DXY21_RS03295 ENOG4105DIK (ABC) transporter DXY21_RS03300 ENOG4105DSE periplasmic solute binding protein DXY21_RS03310 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXY21_RS03340 ENOG4107SET aldo keto reductase DXY21_RS03345 ENOG41060AI SEC-C motif DXY21_RS03350 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DXY21_RS03355 ENOG4107RB3 L-asparaginase DXY21_RS03360 ENOG4105J7D transcriptional regulator DXY21_RS03365 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY21_RS03370 ENOG4107EPV Aminotransferase class V DXY21_RS03375 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DXY21_RS03380 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXY21_RS03385 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXY21_RS03390 ENOG4105DGI Alkaline phosphatase DXY21_RS03405 ENOG4105XXY Thioredoxin DXY21_RS03410 ENOG4108VGI doxx family DXY21_RS03415 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DXY21_RS03420 ENOG4108TVJ Nitroreductase DXY21_RS03425 ENOG41076HS cation diffusion facilitator family transporter DXY21_RS03450 ENOG4105CSV Glutaminase DXY21_RS03460 ENOG4108J5H Homocysteine s-methyltransferase DXY21_RS03465 ENOG4108IQI permease DXY21_RS03470 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXY21_RS03480 ENOG4105C72 UPF0176 protein DXY21_RS03495 ENOG4107ZTW SNARE associated Golgi DXY21_RS03500 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DXY21_RS03505 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DXY21_RS03510 ENOG4107SCQ Iron-containing alcohol dehydrogenase DXY21_RS03545 ENOG4105CXY transporter DXY21_RS03550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DXY21_RS03555 ENOG4107QTZ amino acid DXY21_RS03570 ENOG4106DDH Sporulation-specific SASP protein DXY21_RS03595 ENOG4105CJ1 ABC, transporter DXY21_RS03600 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS03605 ENOG4105BZU Histidine kinase DXY21_RS03620 ENOG41061AU MarR family Transcriptional regulator DXY21_RS03630 ENOG41067MG lrgb family DXY21_RS03640 ENOG4106K80 DXY21_RS03665 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DXY21_RS03670 ENOG4107U5W ybbr family DXY21_RS03675 ENOG4105C8B TIGR00159 family DXY21_RS03685 ENOG4105EMN RNA polymerase sigma factor DXY21_RS03715 ENOG4105EWC Purine nucleoside phosphorylase DXY21_RS03725 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DXY21_RS03740 ENOG4105D17 glycoside hydrolase, family 3 domain protein DXY21_RS03745 ENOG4105EHZ conserved protein UCP016719 DXY21_RS03750 ENOG410874W AraC family transcriptional regulator DXY21_RS03770 ENOG4108SA1 esterase DXY21_RS03780 ENOG4105CHH sulfate transporter DXY21_RS03795 ENOG4108JPW Aminotransferase DXY21_RS03860 ENOG4108NMV polysaccharide deacetylase DXY21_RS03875 ENOG4105D1F ATP-binding protein DXY21_RS03895 ENOG4108I0C methyltransferase DXY21_RS03900 ENOG4108UJD 30S ribosomal protein S9 DXY21_RS03905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DXY21_RS03910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DXY21_RS03915 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DXY21_RS03920 ENOG4108JJB ABC transporter DXY21_RS03925 ENOG4108JJB ABC transporter DXY21_RS03930 ENOG4108ZT0 50S ribosomal protein l17 DXY21_RS03935 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY21_RS03940 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DXY21_RS03945 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DXY21_RS03955 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DXY21_RS03965 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DXY21_RS03970 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DXY21_RS03975 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DXY21_RS03980 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DXY21_RS03985 ENOG4105VPB 50S ribosomal protein L30 DXY21_RS03990 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DXY21_RS03995 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DXY21_RS04000 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DXY21_RS04005 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DXY21_RS04015 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DXY21_RS04025 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DXY21_RS04030 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DXY21_RS04035 ENOG41082SA 50s ribosomal protein l29 DXY21_RS04040 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DXY21_RS04045 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DXY21_RS04050 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DXY21_RS04055 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DXY21_RS04060 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DXY21_RS04065 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DXY21_RS04070 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DXY21_RS04075 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DXY21_RS04080 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DXY21_RS04085 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DXY21_RS04090 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DXY21_RS04095 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DXY21_RS04100 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DXY21_RS04105 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DXY21_RS04110 ENOG4105XPM ribosomal protein DXY21_RS04115 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY21_RS04120 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY21_RS04125 ENOG4107Y49 methyltransferase DXY21_RS04130 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DXY21_RS04135 ENOG4108VZM 50s ribosomal protein L10 DXY21_RS04145 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DXY21_RS04150 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DXY21_RS04170 ENOG4105M0M Tetracycline resistance protein DXY21_RS04175 ENOG4105C2N RNA methyltransferase TrmH family group 3 DXY21_RS04180 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DXY21_RS04190 ENOG4105D7W serine acetyltransferase DXY21_RS04195 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DXY21_RS04200 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DXY21_RS04205 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DXY21_RS04210 ENOG4105CTP PilT protein domain protein DXY21_RS04215 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DXY21_RS04220 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DXY21_RS04230 ENOG41066A3 ATP guanido phosphotransferase DXY21_RS04235 ENOG4108Z0C Uvrb UvrC protein DXY21_RS04320 ENOG4105CRK lysyL-tRNA synthetase DXY21_RS04325 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DXY21_RS04335 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DXY21_RS04340 ENOG4105KRF dihydroneopterin aldolase DXY21_RS04345 ENOG4105EEI dihydropteroate synthase DXY21_RS04350 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DXY21_RS04355 ENOG4105DDQ anthranilate synthase DXY21_RS04360 ENOG4105CRQ synthase (Component I) DXY21_RS04365 ENOG4105C6T cysteine synthase DXY21_RS04370 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DXY21_RS04375 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DXY21_RS04380 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DXY21_RS04385 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DXY21_RS04390 ENOG4108UGV hypoxanthine phosphoribosyltransferase DXY21_RS04395 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DXY21_RS04425 ENOG41060GV RNA binding s1 domain protein DXY21_RS04440 ENOG4105VYY sporulation protein yabp DXY21_RS04445 ENOG41082I2 s4 domain protein DXY21_RS04450 ENOG4108IY2 MazG family DXY21_RS04460 ENOG4108M14 stage v sporulation protein t DXY21_RS04465 ENOG4108JA2 transcriptioN-repair coupling factor DXY21_RS04480 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DXY21_RS04485 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DXY21_RS04490 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DXY21_RS04495 ENOG4105K4W Could be involved in septation (By similarity) DXY21_RS04500 ENOG4105KME endoribonuclease L-psp DXY21_RS04505 ENOG4105DFT pur operon repressor DXY21_RS04510 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DXY21_RS04515 ENOG4105XEW small acid-soluble spore protein DXY21_RS04520 ENOG4105W42 Veg protein DXY21_RS04525 ENOG4105XFA sporulation peptidase YabG DXY21_RS04530 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DXY21_RS04540 ENOG41069ER domain protein DXY21_RS04545 ENOG4105F8V Hydrolase, tatD family DXY21_RS04550 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DXY21_RS04555 ENOG4105KRN Transcriptional regulator, abrb family DXY21_RS04560 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DXY21_RS04565 ENOG4105VC4 domain protein DXY21_RS04570 ENOG41060K3 Methyltransferase DXY21_RS04580 ENOG4105MA4 psp1 domain protein DXY21_RS04585 ENOG4105FA2 dna polymerase iii DXY21_RS04590 ENOG4105XVJ Protein of unknown function (DUF327) DXY21_RS04595 ENOG4105X0R protein from nitrogen regulatory protein P-II DXY21_RS04600 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DXY21_RS04605 ENOG4105CXN decarboxylase DXY21_RS04610 ENOG4105CDW Resistance protein DXY21_RS04650 ENOG41067KS pro-sigma K processing DXY21_RS04660 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DXY21_RS04665 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DXY21_RS04670 ENOG4105C6E dna polymerase iii DXY21_RS04680 ENOG4108Z6B deaminase DXY21_RS04685 ENOG4105GTG Isochorismatase DXY21_RS04690 ENOG4105VRS hydrolase family 18 DXY21_RS04700 ENOG4105ZMH deoxynucleoside kinase DXY21_RS04710 ENOG4105BZW Glycerate kinase DXY21_RS04715 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DXY21_RS04720 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DXY21_RS04725 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DXY21_RS04735 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DXY21_RS04770 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY21_RS04775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY21_RS04785 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DXY21_RS04790 ENOG410848D S4 domain protein YaaA DXY21_RS04795 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DXY21_RS04800 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DXY21_RS04810 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DXY21_RS04825 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DXY21_RS04830 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DXY21_RS04845 ENOG4107QJE Chromosome Partitioning Protein DXY21_RS04850 ENOG4105FA0 parb-like partition protein DXY21_RS04855 ENOG4108ZDA Sporulation protein YyaC DXY21_RS04870 ENOG4105VDK protein, conserved in bacteria DXY21_RS04875 ENOG4108J2R molybdopterin oxidoreductase DXY21_RS04880 ENOG4105C3G gtp-binding protein DXY21_RS04885 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DXY21_RS04890 ENOG4108UUM single-stranded DNA-binding protein DXY21_RS04895 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DXY21_RS04905 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXY21_RS04910 ENOG4105CGK Exodeoxyribonuclease III DXY21_RS04920 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DXY21_RS04930 ENOG4107FCW Abortive infection protein DXY21_RS04935 ENOG4105C7Z Conserved Protein DXY21_RS04940 ENOG4105C7Z Conserved Protein DXY21_RS04945 ENOG4108UQV Membrane DXY21_RS04955 ENOG4105C7Z Conserved Protein DXY21_RS04960 ENOG4107Y9U Membrane DXY21_RS04970 ENOG41082BV acetyltransferase DXY21_RS04975 ENOG4108U05 Transcriptional regulator DXY21_RS04985 ENOG4105FS7 Transcriptional regulator DXY21_RS04990 ENOG4108TVJ Nitroreductase DXY21_RS05010 ENOG4107XBN GntR Family Transcriptional Regulator DXY21_RS05015 ENOG4108HKT sucrose-6-phosphate hydrolase DXY21_RS05020 ENOG4105EDQ levansucrase EC 2.4.1.10 DXY21_RS05025 ENOG4108UZ3 Transporter DXY21_RS05030 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DXY21_RS05035 ENOG4105KVH Transcriptional regulator DXY21_RS05050 ENOG4108XMW Membrane DXY21_RS05055 ENOG4105BZR domain protein DXY21_RS05075 ENOG4105CPK Glycosyl transferase (Group 1 DXY21_RS05080 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DXY21_RS05090 ENOG4107QPH glycogen) synthase DXY21_RS05110 ENOG4105CDU Replicative dna helicase DXY21_RS05115 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DXY21_RS05120 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DXY21_RS05145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY21_RS05150 ENOG4105BZU Histidine kinase DXY21_RS05165 ENOG4105Q2H domain protein DXY21_RS05170 ENOG4105C0H protease DXY21_RS05180 ENOG4105BZU Histidine kinase DXY21_RS05185 ENOG4105D06 uba thif-type nad fad binding protein DXY21_RS05200 ENOG4105C5H ABC transporter DXY21_RS05210 ENOG4108JUB Transcriptional regulator DXY21_RS05215 ENOG41082BM Transcriptional regulator, arsr family DXY21_RS05225 ENOG4105C8Y Acetylornithine aminotransferase DXY21_RS05230 ENOG4108IQI permease DXY21_RS05235 ENOG41066UZ arginase EC 3.5.3.1 DXY21_RS05245 ENOG4105WQG acetyltransferase DXY21_RS05250 ENOG4105CPC Aldo Keto reductase DXY21_RS05255 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) DXY21_RS05270 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DXY21_RS05295 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DXY21_RS05305 ENOG4105XRQ Xanthine dehydrogenase accessory factor DXY21_RS05325 ENOG4108XHQ (2Fe-2S)-binding domain protein DXY21_RS05330 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DXY21_RS05335 ENOG4105C85 amino acid DXY21_RS05340 ENOG4108JU3 Alkyl hydroperoxide reductase DXY21_RS05345 ENOG4105D3R alkyl hydroperoxide reductase DXY21_RS05360 ENOG4105F27 Major Facilitator DXY21_RS05365 ENOG4105WAB arsR family transcriptional regulator DXY21_RS05375 ENOG4108ITS PQQ enzyme repeat DXY21_RS05380 ENOG4105C26 Dehydrogenase DXY21_RS05385 ENOG4105ST3 Transcriptional regulator DXY21_RS05390 ENOG4105ECK Fatty Acid Desaturase DXY21_RS05395 ENOG4108ZGX Histidine kinase DXY21_RS05400 ENOG4108S01 response regulator DXY21_RS05405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DXY21_RS05415 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DXY21_RS05420 ENOG4107QNK )-transporter DXY21_RS05425 ENOG4105CPC Aldo Keto reductase DXY21_RS05435 ENOG4105C26 Dehydrogenase DXY21_RS05445 ENOG4105EDK PfkB domain protein DXY21_RS05455 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DXY21_RS05465 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXY21_RS05470 ENOG4105F0H myo-inositol catabolism protein DXY21_RS05475 ENOG4105WZ4 isomerase DXY21_RS05510 ENOG4108V5C ABC transporter DXY21_RS05540 ENOG410667J hydrolase DXY21_RS05545 ENOG4107RHR regulatoR DXY21_RS05550 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DXY21_RS05555 ENOG4105D9N nucleoside DXY21_RS05560 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DXY21_RS05570 ENOG4107W25 arginase agmatinase formiminoglutamase DXY21_RS05575 ENOG4105CI2 imidazolone-5-propionate hydrolase DXY21_RS05580 ENOG4105CGP Urocanate hydratase DXY21_RS05585 ENOG4105C84 Histidine ammonia-lyase DXY21_RS05595 ENOG4106Z5D Glycoside Hydrolase Family 43 DXY21_RS05600 ENOG4105M6F mutator MutT protein DXY21_RS05610 ENOG4107YZX Universal stress protein DXY21_RS05620 ENOG4108NR7 pectate lyase DXY21_RS05680 ENOG4105C1J atp-dependent rna helicase DXY21_RS05685 ENOG4105DEU major facilitator superfamily DXY21_RS05700 ENOG4105D4T Citrate transporter DXY21_RS05705 ENOG4105CH6 catalase DXY21_RS05725 ENOG4105DHI Methyltransferase DXY21_RS05740 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXY21_RS05745 ENOG4105CMR udp-glucose 4-epimerase DXY21_RS05755 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DXY21_RS05770 ENOG4107BJW polysaccharide deacetylase DXY21_RS05775 ENOG4105D2K citrate carrier protein DXY21_RS05780 ENOG4105C4M (Ubiquinol oxidase) subunit I DXY21_RS05785 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DXY21_RS05790 ENOG4108JJ9 ABC, transporter DXY21_RS05795 ENOG4108JJ8 (ABC) transporter DXY21_RS05800 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DXY21_RS05805 ENOG4105ETS cytosine purines uracil thiamine allantoin DXY21_RS05810 ENOG4107QHE Choloylglycine hydrolase DXY21_RS05815 ENOG4105CH6 catalase DXY21_RS05825 ENOG4105DG6 mannose-6-phosphate isomerase DXY21_RS05830 ENOG4105EVU fructokinase DXY21_RS05835 ENOG4105CS2 ec 3.2.1.21 DXY21_RS05840 ENOG4105CK1 PTS System DXY21_RS05845 ENOG4105VCP PTS System DXY21_RS05850 ENOG4105VZJ PTS System DXY21_RS05855 ENOG4107R5R arsenical pump membrane protein DXY21_RS05860 ENOG41082YX Transcriptional regulator, arsr family DXY21_RS05870 ENOG4105EHG Permease protein DXY21_RS05875 ENOG4105DQ5 transport system permease protein DXY21_RS05885 ENOG4105EMD TRANSCRIPTIONal DXY21_RS05890 ENOG4105VZJ PTS System DXY21_RS05895 ENOG4105CK1 PTS System DXY21_RS05900 ENOG4105VCP PTS System DXY21_RS05905 ENOG4105F8D glycoside hydrolase family 4 DXY21_RS05910 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXY21_RS05915 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DXY21_RS05920 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DXY21_RS05925 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DXY21_RS05930 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DXY21_RS05940 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DXY21_RS05950 ENOG4105X1N Glycosyl transferase family 8 DXY21_RS05955 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin DXY21_RS05960 ENOG4105CK1 PTS System DXY21_RS05970 ENOG4105DR4 Methyltransferase DXY21_RS05975 ENOG4107TXC Transcriptional regulator DXY21_RS05985 ENOG41067MG lrgb family DXY21_RS05990 ENOG4105VAW lrga family DXY21_RS05995 ENOG4105CMU LysR family (Transcriptional regulator DXY21_RS06000 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DXY21_RS06005 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DXY21_RS06020 ENOG4105DBE peroxidase DXY21_RS06025 ENOG4107ZXU DSBA oxidoreductase DXY21_RS06050 ENOG4105WH5 Teichoic acid glycosylation protein DXY21_RS06065 ENOG4107BMA Transglycosylase associated protein DXY21_RS06070 ENOG4105E2S oxidase) subunit II DXY21_RS06075 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXY21_RS06095 ENOG4105I4A GCN5-related N-acetyltransferase DXY21_RS06105 ENOG4108DBC nitroreductase DXY21_RS06110 ENOG4105DEN Luciferase family DXY21_RS06115 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY21_RS06130 ENOG4105C5Y PTS System DXY21_RS06145 ENOG4105DWF phosphomethylpyrimidine kinase DXY21_RS06165 ENOG4108RJ9 Glycosyl transferase, family 2 DXY21_RS06170 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DXY21_RS06205 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY21_RS06210 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD DXY21_RS06220 ENOG4107TY6 Acylneuraminate cytidylyltransferase DXY21_RS06225 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG DXY21_RS06230 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DXY21_RS06235 ENOG4105C1B dTDP-glucose 4-6-dehydratase DXY21_RS06240 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DXY21_RS06245 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase DXY21_RS06255 ENOG4105D82 Glutamate dehydrogenase DXY21_RS06260 ENOG4105C26 Dehydrogenase DXY21_RS06275 ENOG4105C2C drug resistance transporter, Bcr CflA DXY21_RS06280 ENOG4105FCW Major Facilitator superfamily DXY21_RS06310 ENOG4105CHM Aminotransferase DXY21_RS06320 ENOG4107JTW chlorite dismutase DXY21_RS06325 ENOG4108IJ2 phosphate acetyltransferase DXY21_RS06335 ENOG4105DUM transcriptional regulator, lysR family DXY21_RS06340 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DXY21_RS06365 ENOG4108TU7 Inherit from COG: (ABC) transporter DXY21_RS06370 ENOG4105CJ1 ABC, transporter DXY21_RS06380 ENOG4105K7K Transcriptional regulator DXY21_RS06385 ENOG4108VCI transcription factor, rsfa family DXY21_RS06395 ENOG4105DCI Phosphohydrolase DXY21_RS06405 ENOG4105CUB amino acid DXY21_RS06410 ENOG41067TZ transcriptional regulator, MarR family DXY21_RS06415 ENOG41069HH 4-oxalocrotonate tautomerase DXY21_RS06420 ENOG4108Z4T Peptidase M50 DXY21_RS06425 ENOG4108XFG YwhD family DXY21_RS06435 ENOG4105BZ4 penicillin-binding protein DXY21_RS06440 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DXY21_RS06445 ENOG4105CYW agmatinase DXY21_RS06490 ENOG4107JM4 Tetratricopeptide repeat DXY21_RS06495 ENOG410684U Domain of unknown function (DUF1934) DXY21_RS06500 ENOG4105C75 arginyL-tRNA synthetase DXY21_RS06510 ENOG4107V6Q Cyclic nucleotide-binding domain DXY21_RS06530 ENOG4108IUE nitrate reductase beta subunit DXY21_RS06535 ENOG4105R3A Nitrate reductase DXY21_RS06550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXY21_RS06555 ENOG4105BZ1 (ABC) transporter DXY21_RS06565 ENOG4105E5J UV damage endonuclease DXY21_RS06575 ENOG4105DF6 Fe-S oxidoreductase DXY21_RS06585 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DXY21_RS06595 ENOG410812K response regulator receiver protein DXY21_RS06600 ENOG4105D2N Aldolase DXY21_RS06610 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXY21_RS06615 ENOG4105CBT Fructose-1,6-bisphosphatase DXY21_RS06620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DXY21_RS06625 ENOG41082DI 50s ribosomal protein l31 DXY21_RS06630 ENOG4107104 thymidine kinase DXY21_RS06635 ENOG4105C6K Malic enzyme DXY21_RS06640 ENOG4107TT2 Auxin Efflux Carrier DXY21_RS06650 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DXY21_RS06655 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DXY21_RS06660 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DXY21_RS06675 ENOG4108ZXQ stage ii sporulation protein r DXY21_RS06685 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXY21_RS06690 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DXY21_RS06695 ENOG4107WAU Protein tyrosine phosphatase DXY21_RS06700 ENOG4108YZG isomerase DXY21_RS06705 ENOG4108UIC UPF0340 protein DXY21_RS06710 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DXY21_RS06715 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DXY21_RS06725 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DXY21_RS06740 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DXY21_RS06745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DXY21_RS06750 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DXY21_RS06755 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DXY21_RS06760 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DXY21_RS06770 ENOG4106778 Protein of unknown function (DUF1146) DXY21_RS06780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXY21_RS06795 ENOG4108TF4 von Willebrand factor, type A DXY21_RS06800 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DXY21_RS06805 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DXY21_RS06825 ENOG4108YZ9 Urea amidohydrolase subunit gamma DXY21_RS06830 ENOG4105KI2 Urea amidohydrolase subunit beta DXY21_RS06835 ENOG4105CQM Urea amidohydrolase subunit alpha DXY21_RS06840 ENOG4108Z40 Transcriptional regulator DXY21_RS06850 ENOG4107T94 Endo-14-beta-xylanase DXY21_RS06855 ENOG4106BRK DXY21_RS06860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXY21_RS06875 ENOG4107TCE N-acetyltransferase DXY21_RS06880 ENOG4105FRN stage II sporulation protein DXY21_RS06890 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DXY21_RS06895 ENOG4105CNI cell division protein FtsW DXY21_RS06905 ENOG4105BZU Histidine kinase DXY21_RS06910 ENOG4105D3W isochorismatase DXY21_RS06915 ENOG41080V3 Major Facilitator superfamily DXY21_RS06920 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DXY21_RS06925 ENOG4105CZM Major Facilitator DXY21_RS06930 ENOG4107MII Sugar-specific transcriptional regulator TrmB DXY21_RS06935 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DXY21_RS06940 ENOG4105DFF Rod shape-determining protein mreb DXY21_RS06950 ENOG4105CGA flagellar basal-body rod protein FlgG DXY21_RS06960 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DXY21_RS06965 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DXY21_RS06980 ENOG4105Z8H single-stranded DNA-binding protein DXY21_RS06985 ENOG4105E98 transcriptional regulator DeoR family DXY21_RS06990 ENOG410667J hydrolase DXY21_RS06995 ENOG4105C0D helicase DXY21_RS07000 ENOG4105KBK Zinc finger, swim domain protein DXY21_RS07010 ENOG4105HTX biosynthesis protein DXY21_RS07015 ENOG4107YJ4 chain length determinant protein DXY21_RS07020 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DXY21_RS07025 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXY21_RS07030 ENOG4108XI2 Domain of unknown function (DUF1963) DXY21_RS07070 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) DXY21_RS07075 ENOG4107V2S Transcriptional regulator DXY21_RS07080 ENOG4108WS4 fmn reductase DXY21_RS07090 ENOG4105FGV Chromate DXY21_RS07095 ENOG4105CAH Chromate DXY21_RS07105 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXY21_RS07115 ENOG4107XC4 flavin reductase domain protein, FMN-binding DXY21_RS07130 ENOG4106UIA DXY21_RS07145 ENOG4107RSM transcriptional regulator DXY21_RS07155 ENOG4107FQX Alpha-acetolactate decarboxylase DXY21_RS07160 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXY21_RS07170 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DXY21_RS07175 ENOG4105CNN ABC, transporter DXY21_RS07180 ENOG4105C2J ABC transporter DXY21_RS07185 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DXY21_RS07190 ENOG4108RVA ribokinase DXY21_RS07195 ENOG4105ETE Transcriptional regulator (LacI family DXY21_RS07210 ENOG4105E1K spore germination protein DXY21_RS07215 ENOG4105N98 Capsule biosynthesis protein capB DXY21_RS07225 ENOG4105PNM synthesis protein DXY21_RS07235 ENOG4105K4H Nlp p60 protein DXY21_RS07240 ENOG4106UBQ DXY21_RS07245 ENOG4105J7I hydrolase DXY21_RS07250 ENOG4108KGH TRANSCRIPTIONal DXY21_RS07255 ENOG4105C54 Major Facilitator superfamily DXY21_RS07260 ENOG4107R8N Glycosyl transferase, family 2 DXY21_RS07265 ENOG4108NHD germination protein DXY21_RS07280 ENOG4105DG6 mannose-6-phosphate isomerase DXY21_RS07290 ENOG4107RZX Teichoic acid biosynthesis protein DXY21_RS07300 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DXY21_RS07310 ENOG4107SJB teichoic acid biosynthesis DXY21_RS07320 ENOG4105EY8 ABC transporter DXY21_RS07325 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXY21_RS07330 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DXY21_RS07345 ENOG4105JFG SpoIID LytB domain protein DXY21_RS07350 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY21_RS07355 ENOG4105D3Q Sugar transferase DXY21_RS07360 ENOG4105PSV Polysaccharide Biosynthesis Protein DXY21_RS07365 ENOG4107RA4 Glycosyl transferase (Group 1 DXY21_RS07370 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXY21_RS07375 ENOG4105QZI O-Antigen Polymerase DXY21_RS07390 ENOG4107EF8 Glycosyl transferase (Group 1 DXY21_RS07395 ENOG4105ESV Glycosyl transferase, family 4 DXY21_RS07400 ENOG4108KGH TRANSCRIPTIONal DXY21_RS07405 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DXY21_RS07410 ENOG4105BZU Histidine kinase DXY21_RS07415 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS07435 ENOG41081UC Inherit from COG: Competence protein DXY21_RS07440 ENOG4105RU3 DXY21_RS07455 ENOG4105E1Q flagellar hook-associated protein DXY21_RS07460 ENOG4105DTJ flagellar hook-associated protein DXY21_RS07470 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DXY21_RS07475 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DXY21_RS07480 ENOG4105I03 Flagellin DXY21_RS07485 ENOG4107RT6 flagellar hook-associated DXY21_RS07490 ENOG4105MQ3 flagellar protein FliS DXY21_RS07505 ENOG4105MS2 ribosomal subunit Interface protein DXY21_RS07510 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DXY21_RS07530 ENOG4105CAK Cell division ATP-binding protein ftsE DXY21_RS07535 ENOG4105CRP Part of the ABC transporter FtsEX involved in DXY21_RS07540 ENOG4108M26 parallel beta-helix repeat protein DXY21_RS07545 ENOG4105CN1 protease DXY21_RS07590 ENOG4105MKU Transcriptional regulator DXY21_RS07605 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DXY21_RS07610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DXY21_RS07625 ENOG4108PY7 DXY21_RS07630 ENOG41067S9 phage shock protein C, PspC DXY21_RS07635 ENOG41086DT Membrane protein of unknown function DXY21_RS07640 ENOG41088CQ domain protein DXY21_RS07645 ENOG4105J7D transcriptional regulator DXY21_RS07650 ENOG4105FDP GntR family transcriptional regulator DXY21_RS07655 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DXY21_RS07660 ENOG4105CE4 GlcNAc 6-P deacetylase DXY21_RS07665 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DXY21_RS07675 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DXY21_RS07680 ENOG4108S4C acetyltransferase DXY21_RS07690 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DXY21_RS07695 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DXY21_RS07700 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DXY21_RS07705 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DXY21_RS07710 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DXY21_RS07715 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DXY21_RS07720 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DXY21_RS07725 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DXY21_RS07730 ENOG4105BZ1 (ABC) transporter DXY21_RS07735 ENOG4105GIG DXY21_RS07740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY21_RS07745 ENOG4105BZU Histidine kinase DXY21_RS07760 ENOG4105C3M thioredoxin reductase DXY21_RS07765 ENOG4108Z4K mutator MutT protein DXY21_RS07770 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DXY21_RS07775 ENOG4105CHW UPF0052 protein DXY21_RS07780 ENOG4105CIE May be required for sporulation (By similarity) DXY21_RS07785 ENOG4105KRI phosphocarrier protein (HPr DXY21_RS07790 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DXY21_RS07795 ENOG4105GGE ribonuclease DXY21_RS07800 ENOG4105C5I Dehydrogenase DXY21_RS07805 ENOG4108V2W Carbonate dehydratase DXY21_RS07810 ENOG4105CHH sulfate transporter DXY21_RS07815 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DXY21_RS07820 ENOG4108URH decarboxylase DXY21_RS07830 ENOG4105C7F AcnD-accessory protein PrpF DXY21_RS07835 ENOG4108KAM Transcriptional regulator DXY21_RS07840 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DXY21_RS07845 ENOG4105ETE Transcriptional regulator (LacI family DXY21_RS07850 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) DXY21_RS07855 ENOG4108HKT sucrose-6-phosphate hydrolase DXY21_RS07890 ENOG4105NI3 Protein of unknown function (DUF3237) DXY21_RS07895 ENOG4105PY6 Phenolic acid decarboxylase DXY21_RS07900 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DXY21_RS07910 ENOG4105NAE bifunctional deaminase-reductase domain protein DXY21_RS07920 ENOG4105EBR Carboxylesterase DXY21_RS07930 ENOG4105HTX biosynthesis protein DXY21_RS07935 ENOG4108QV3 biosynthesis protein DXY21_RS07945 ENOG4108PQP glycosyl transferase group 1 DXY21_RS07950 ENOG4105K64 Glycosyl transferase, family 2 DXY21_RS07955 ENOG4108KMV Glycosyl transferase (Group 1 DXY21_RS07960 ENOG41068W6 Capsular polysaccharide biosynthesis protein DXY21_RS07965 ENOG4107QRS glycosyltransferase group 2 family protein DXY21_RS07975 ENOG4105K64 Glycosyl transferase, family 2 DXY21_RS07985 ENOG4105D3Q Sugar transferase DXY21_RS07990 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family DXY21_RS07995 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY21_RS08000 ENOG4108ZPC Polysaccharide pyruvyl transferase DXY21_RS08010 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS08015 ENOG4105DAA L-lactate DXY21_RS08020 ENOG4105JXH GntR family transcriptional regulator DXY21_RS08025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXY21_RS08030 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXY21_RS08035 ENOG4107QR9 Iron-sulfur cluster binding protein DXY21_RS08045 ENOG4105C6Z Gluconate DXY21_RS08050 ENOG4105CMG Carbohydrate kinase DXY21_RS08055 ENOG4106KNT transcriptional regulator DXY21_RS08065 ENOG4107RT3 EamA-like transporter family DXY21_RS08070 ENOG4105GZI Transcriptional regulator DXY21_RS08080 ENOG4105DEN Luciferase family DXY21_RS08085 ENOG4105CMD Transcriptional regulator, GntR family DXY21_RS08100 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXY21_RS08105 ENOG4105BZA Phosphoglycerate kinase DXY21_RS08110 ENOG4105CP7 Triose-phosphate isomerase DXY21_RS08115 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DXY21_RS08120 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DXY21_RS08125 ENOG4105IIU Aminopeptidase DXY21_RS08130 ENOG4107QQG Dehydrogenase DXY21_RS08135 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY21_RS08140 ENOG4108IAJ Nad-dependent epimerase dehydratase DXY21_RS08145 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY21_RS08160 ENOG4105FJR Lmbe family DXY21_RS08175 ENOG4108W0I acetyltransferase DXY21_RS08180 ENOG4105T65 Membrane-associated protein DXY21_RS08190 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DXY21_RS08195 ENOG4107HG4 Transcriptional regulator DXY21_RS08200 ENOG4108IJ8 ABC transporter DXY21_RS08205 ENOG4105E90 ABC transporter DXY21_RS08210 ENOG4108HQR Glycine betaine DXY21_RS08215 ENOG4105R40 Glycine betaine carnitine choline DXY21_RS08220 ENOG4107HG4 Transcriptional regulator DXY21_RS08225 ENOG4108IJ8 ABC transporter DXY21_RS08230 ENOG4105E90 ABC transporter DXY21_RS08235 ENOG4108HQR Glycine betaine DXY21_RS08240 ENOG4105R40 Glycine betaine carnitine choline DXY21_RS08245 ENOG4105DA5 (ABC) transporter DXY21_RS08270 ENOG4105KVH Transcriptional regulator DXY21_RS08290 ENOG4105XZU Preprotein translocase, subunit SecG DXY21_RS08300 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DXY21_RS08305 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DXY21_RS08315 ENOG41067XF inhibitor DXY21_RS08320 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXY21_RS08325 ENOG4108KSA LysR family transcriptional regulator DXY21_RS08330 ENOG4108XSB acetyltransferase, (GNAT) family DXY21_RS08355 ENOG4105CDA abc transporter atp-binding protein DXY21_RS08360 ENOG4105DEN Luciferase family DXY21_RS08395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXY21_RS08400 ENOG4105D9R oxidoreductase DXY21_RS08405 ENOG4105VPX protein, conserved in bacteria DXY21_RS08410 ENOG410681U heavy metal transport detoxification protein DXY21_RS08415 ENOG4105C59 p-type ATPase DXY21_RS08420 ENOG4105C59 p-type ATPase DXY21_RS08425 ENOG4107ZQN disulfide bond DXY21_RS08440 ENOG4105EN6 Membrane DXY21_RS08445 ENOG4105EEM helicase DXY21_RS08450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY21_RS08455 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DXY21_RS08460 ENOG4105EEQ Na H antiporter DXY21_RS08475 ENOG4108KYE ABC-2 type transporter DXY21_RS08485 ENOG4105CJ1 ABC, transporter DXY21_RS08490 ENOG4105BZU Histidine kinase DXY21_RS08495 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS08500 ENOG4105E0C molybdate abc transporter DXY21_RS08505 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DXY21_RS08515 ENOG4107QZ2 Sulfatase DXY21_RS08520 ENOG4107K5X Membrane-bound metal-dependent hydrolase DXY21_RS08530 ENOG4105D5Q Arginine ornithine antiporter DXY21_RS08535 ENOG4105JQZ Methyltransferase DXY21_RS08545 ENOG4105DQ5 transport system permease protein DXY21_RS08550 ENOG4105EHG Permease protein DXY21_RS08555 ENOG4105E0A ABC, transporter DXY21_RS08565 ENOG4105F0F Oxalate decarboxylase DXY21_RS08575 ENOG4106DF4 Sigma-70, region 4 DXY21_RS08585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY21_RS08595 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DXY21_RS08600 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXY21_RS08605 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DXY21_RS08610 ENOG4105EHG Permease protein DXY21_RS08615 ENOG4105E0A ABC, transporter DXY21_RS08620 ENOG4108WBT adenosyltransferase DXY21_RS08635 ENOG41087YS Phage shock protein A DXY21_RS08650 ENOG4105ENE Histidine kinase DXY21_RS08655 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS08680 ENOG4105C9Q fumarate hydratase class II DXY21_RS08685 ENOG41067SE Tetr family transcriptional regulator DXY21_RS08695 ENOG4105F3H Histidine kinase DXY21_RS08705 ENOG4105C0H protease DXY21_RS08710 ENOG4105HUF DNA protection during starvation protein DXY21_RS08715 ENOG4105E1F short-chain dehydrogenase reductase DXY21_RS08730 ENOG4105E0A ABC, transporter DXY21_RS08750 ENOG4105C5Q Transcriptional regulator DXY21_RS08755 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY21_RS08760 ENOG41067TZ transcriptional regulator, MarR family DXY21_RS08790 ENOG4105CHU acetyl-coa acetyltransferase DXY21_RS08795 ENOG4105C1G acyl-Coa dehydrogenase DXY21_RS08800 ENOG41080E8 Transcriptional regulator, Spx MgsR family DXY21_RS08805 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DXY21_RS08830 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DXY21_RS08835 ENOG4108UMI ABC transporter, permease DXY21_RS08840 ENOG4105D01 (LipO)protein DXY21_RS08855 ENOG4105C3K feS assembly ATPase SufC DXY21_RS08860 ENOG4105JRK feS assembly protein SufD DXY21_RS08865 ENOG4105C9B Cysteine desulfurase DXY21_RS08870 ENOG4108UNV SUF system FeS assembly protein, NifU family DXY21_RS08875 ENOG4105DIW FeS assembly protein SUFB DXY21_RS08880 ENOG41083Q9 chitosanase DXY21_RS08890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DXY21_RS08895 ENOG4107VFR oxidoreductase DXY21_RS08900 ENOG4105PKS Excinuclease abc c subunit domain protein DXY21_RS08910 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine DXY21_RS08915 ENOG4105XN3 extracellular solute-binding protein family 1 DXY21_RS08920 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DXY21_RS08925 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DXY21_RS08930 ENOG4108KPW sugar kinase DXY21_RS08935 ENOG4105FDP GntR family transcriptional regulator DXY21_RS08940 ENOG4108IJ9 (ABC) transporter DXY21_RS08945 ENOG4108K8S endonuclease I DXY21_RS08955 ENOG4105C5R Aminotransferase DXY21_RS08980 ENOG4105G9B Transcriptional regulator DXY21_RS08985 ENOG4105CD3 dihydroorotase DXY21_RS08995 ENOG4105I3N Conserved Protein DXY21_RS09005 ENOG4107R8B 5'-nucleotidase DXY21_RS09010 ENOG4108YTE sporulation protein YunB DXY21_RS09015 ENOG4105FAA peptidase M23 DXY21_RS09020 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DXY21_RS09025 ENOG4105MMD transcriptional regulator DXY21_RS09035 ENOG4105D4U had-superfamily hydrolase, subfamily iia DXY21_RS09040 ENOG4108W5N phosphatidylglycerophosphatase a DXY21_RS09050 ENOG4105D6E homoserine dehydrogenase DXY21_RS09055 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DXY21_RS09060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DXY21_RS09065 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DXY21_RS09070 ENOG41083MR nifu domain-containing protein DXY21_RS09085 ENOG4105ZKE UPF0349 protein DXY21_RS09095 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DXY21_RS09100 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DXY21_RS09105 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DXY21_RS09130 ENOG4105CJ1 ABC, transporter DXY21_RS09145 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DXY21_RS09155 ENOG4105CEP NADH dehydrogenase DXY21_RS09170 ENOG41069ER domain protein DXY21_RS09180 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DXY21_RS09200 ENOG4105NIV Esterase DXY21_RS09205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DXY21_RS09210 ENOG4105E4F Isochorismate synthase DXY21_RS09215 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DXY21_RS09220 ENOG4105WQI isochorismatase DXY21_RS09225 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS09230 ENOG4105WQT MbtH domain protein DXY21_RS09240 ENOG4105DCF alanine dehydrogenase DXY21_RS09245 ENOG4108K8K Transcriptional regulator DXY21_RS09280 ENOG410904N short-chain dehydrogenase reductase DXY21_RS09295 ENOG4105C02 permease DXY21_RS09320 ENOG4105DAP Nicotinate phosphoribosyltransferase DXY21_RS09325 ENOG4105D58 Diguanylate phosphodiesterase DXY21_RS09350 ENOG4105BZU Histidine kinase DXY21_RS09360 ENOG4105KA0 thioesterase Superfamily protein DXY21_RS09365 ENOG4105KJM monovalent cation h antiporter subunit g DXY21_RS09375 ENOG4105SC1 monovalent cation H antiporter subunit E DXY21_RS09380 ENOG4108JPZ Monovalent cation H antiporter subunit D DXY21_RS09385 ENOG4108ZE9 Monovalent cation H antiporter subunit C DXY21_RS09390 ENOG4105HC0 Na H antiporter DXY21_RS09395 ENOG4105D65 subunit l DXY21_RS09410 ENOG4105UIB (ABC) transporter DXY21_RS09415 ENOG4108JQ9 ABC transporter DXY21_RS09420 ENOG4105DIH basic membrane DXY21_RS09425 ENOG4108MRH transcriptional regulatory protein DXY21_RS09440 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DXY21_RS09445 ENOG4105BZ4 penicillin-binding protein DXY21_RS09460 ENOG4105Y38 Kinase-associated protein B DXY21_RS09465 ENOG4108HGU Histidine kinase DXY21_RS09470 ENOG4105C87 Aminotransferase class I and II DXY21_RS09480 ENOG4108MUZ hydrolase DXY21_RS09485 ENOG4108ZB6 transcriptional regulator AsnC family DXY21_RS09490 ENOG4105CHM Aminotransferase DXY21_RS09500 ENOG4105WG9 Conserved Protein DXY21_RS09505 ENOG4107QW4 alcohol dehydrogenase DXY21_RS09515 ENOG4105CHJ isochorismatase hydrolase DXY21_RS09525 ENOG4107QYV phosphohexose isomerase DXY21_RS09540 ENOG4107PBV potassium channel DXY21_RS09545 ENOG4107PBV potassium channel DXY21_RS09560 ENOG4105C37 (CBS) domain DXY21_RS09570 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DXY21_RS09575 ENOG4105EA8 2-Nitropropane dioxygenase DXY21_RS09590 ENOG4105C8Q Methyl-accepting chemotaxis DXY21_RS09595 ENOG4105C8Q Methyl-accepting chemotaxis DXY21_RS09600 ENOG4105C8Q Methyl-accepting chemotaxis DXY21_RS09605 ENOG4105C8Q Methyl-accepting chemotaxis DXY21_RS09610 ENOG4108Z0Z intracellular protease Pfpi family DXY21_RS09615 ENOG4105EE0 oxidoreductase DXY21_RS09625 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DXY21_RS09645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DXY21_RS09650 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DXY21_RS09665 ENOG4105TRT Transcriptional regulator DXY21_RS09670 ENOG4105C26 Dehydrogenase DXY21_RS09675 ENOG4108JB8 alcohol dehydrogenase DXY21_RS09680 ENOG4108VNY MOSC domain protein DXY21_RS09685 ENOG4106DF1 DXY21_RS09695 ENOG4105DZ6 Band 7 protein DXY21_RS09700 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DXY21_RS09835 ENOG4105E4F Isochorismate synthase DXY21_RS09840 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DXY21_RS09845 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DXY21_RS09850 ENOG4108IPT Naphthoate synthase DXY21_RS09855 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS09860 ENOG4105DTQ mandelate racemase muconate lactonizing DXY21_RS09880 ENOG4105NRA 50s ribosomal protein l31 type b DXY21_RS09885 ENOG4108V2W Carbonate dehydratase DXY21_RS09890 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DXY21_RS09895 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DXY21_RS09910 ENOG4108RMU ferritin dps family protein DXY21_RS09925 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DXY21_RS09935 ENOG4105D2X ABC transporter substrate-binding protein DXY21_RS09950 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DXY21_RS09955 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DXY21_RS09960 ENOG4105CAQ asparagine synthetase DXY21_RS09965 ENOG4105C85 amino acid DXY21_RS09970 ENOG4108Z0R Transferase DXY21_RS09975 ENOG4105E8V Alpha Beta Hydrolase Fold protein DXY21_RS09985 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DXY21_RS10000 ENOG4105N5T Radical SAM Protein DXY21_RS10020 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DXY21_RS10025 ENOG4105DVE abc transporter atp-binding protein DXY21_RS10045 ENOG4105C19 ABC transporter DXY21_RS10050 ENOG4107R34 abc transporter permease protein DXY21_RS10060 ENOG4105EWM Histidine kinase DXY21_RS10065 ENOG4105C19 ABC transporter DXY21_RS10080 ENOG410605W Major Facilitator DXY21_RS10085 ENOG4105BZU Histidine kinase DXY21_RS10095 ENOG4105C8T Leucyl-tRNA synthetase DXY21_RS10100 ENOG41085GJ domain protein DXY21_RS10115 ENOG4105I1K ABC transporter DXY21_RS10120 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DXY21_RS10140 ENOG4105C94 Transporter DXY21_RS10145 ENOG4105CBX hi0933 family DXY21_RS10160 ENOG4105YW5 deoR family transcriptional regulator DXY21_RS10175 ENOG4105C7N Xanthine uracil vitamin C permease DXY21_RS10180 ENOG4107QSE Dipeptidase DXY21_RS10185 ENOG4105C6T cysteine synthase DXY21_RS10190 ENOG4107F58 2'-5' rna ligase DXY21_RS10205 ENOG4108V15 phosphotransferase enzyme family DXY21_RS10215 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DXY21_RS10220 ENOG4105C8F Beta-lactamase domain protein DXY21_RS10225 ENOG4105C6K Malic enzyme DXY21_RS10240 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DXY21_RS10255 ENOG4108VDD TRNA binding domain protein DXY21_RS10265 ENOG4105DFU Cell wall formation (By similarity) DXY21_RS10285 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DXY21_RS10290 ENOG4105ETE Transcriptional regulator (LacI family DXY21_RS10295 ENOG4107R0U MotA TolQ exbB proton channel DXY21_RS10300 ENOG4105ER2 Ompa motb domain protein DXY21_RS10305 ENOG4105DGU Histone deacetylase DXY21_RS10310 ENOG4105W87 Cbs domain DXY21_RS10315 ENOG4105F1V Acetoin utilization protein DXY21_RS10325 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DXY21_RS10340 ENOG4108NGU Transcriptional regulator DXY21_RS10360 ENOG4108Z0Z intracellular protease Pfpi family DXY21_RS10370 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DXY21_RS10380 ENOG4105C26 Dehydrogenase DXY21_RS10385 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DXY21_RS10395 ENOG4105BZU Histidine kinase DXY21_RS10405 ENOG4105U5Y Transcriptional regulator DXY21_RS10430 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DXY21_RS10440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DXY21_RS10445 ENOG4105EFZ amidohydrolase DXY21_RS10450 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXY21_RS10455 ENOG4105D07 Signal peptide peptidase, SppA DXY21_RS10460 ENOG4105VK3 rdd domain containing protein DXY21_RS10470 ENOG4105KBJ sporulation protein ytfj DXY21_RS10475 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DXY21_RS10485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DXY21_RS10490 ENOG4105EPU Molybdenum cofactor synthesis domain protein DXY21_RS10495 ENOG4105CDH Citrulline--aspartate ligase DXY21_RS10500 ENOG4105CH7 arginosuccinase DXY21_RS10510 ENOG4105E8R UPF0173 metal-dependent hydrolase DXY21_RS10525 ENOG4105SFS phosphoesterase RecJ domain protein DXY21_RS10530 ENOG4106EVM DXY21_RS10540 ENOG4105VV2 DXY21_RS10545 ENOG4105C0B DNA polymerase III (alpha subunit) DXY21_RS10550 ENOG4105C6K Malic enzyme DXY21_RS10555 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DXY21_RS10560 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DXY21_RS10565 ENOG4105CTQ phosphohexokinase DXY21_RS10570 ENOG4105CA9 Pyruvate kinase DXY21_RS10575 ENOG4105FS0 cytoplasmic membrane protein DXY21_RS10580 ENOG4108REF Sporulation integral membrane protein ytvi DXY21_RS10595 ENOG4105G7B Protein of unknown function (DUF2992) DXY21_RS10600 ENOG4105BZN citrate synthase DXY21_RS10605 ENOG4108HMX isocitrate dehydrogenase (NADP) DXY21_RS10615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY21_RS10620 ENOG4105BZU Histidine kinase DXY21_RS10625 ENOG4105C2M dna polymerase I DXY21_RS10630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DXY21_RS10640 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DXY21_RS10645 ENOG4105CV8 reductase DXY21_RS10650 ENOG4105F27 Major Facilitator DXY21_RS10655 ENOG4105KVH Transcriptional regulator DXY21_RS10660 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXY21_RS10665 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DXY21_RS10690 ENOG4108TDW sporulation protein YtxC DXY21_RS10695 ENOG4105C22 threonyL-tRNA synthetase DXY21_RS10700 ENOG4105U0R haloacid dehalogenase-like hydrolase DXY21_RS10705 ENOG4108HRK Histidine kinase DXY21_RS10710 ENOG4105DY9 regulatoR DXY21_RS10720 ENOG41067MG lrgb family DXY21_RS10725 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DXY21_RS10730 ENOG4105VJV 50s ribosomal protein L35 DXY21_RS10735 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DXY21_RS10740 ENOG410696E Membrane DXY21_RS10750 ENOG4105CN9 Peptidase m42 family protein DXY21_RS10755 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DXY21_RS10765 ENOG4105EF1 ribulokinase DXY21_RS10770 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase DXY21_RS10780 ENOG4108MDK Dehydrogenase DXY21_RS10795 ENOG4105DRS transport system, permease DXY21_RS10800 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXY21_RS10810 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXY21_RS10815 ENOG4105CQB FAD linked oxidase domain protein DXY21_RS10825 ENOG41067MF small acid-soluble spore protein DXY21_RS10830 ENOG4108RWN rrna methyltransferase DXY21_RS10835 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DXY21_RS10840 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DXY21_RS10845 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXY21_RS10860 ENOG4105DCG PHP domain protein DXY21_RS10865 ENOG4105C98 muts2 protein DXY21_RS10880 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS10885 ENOG4107Z3H Transcriptional regulator, TetR family DXY21_RS10890 ENOG41060WC Enoyl-CoA hydratase DXY21_RS10895 ENOG4105BZJ Electron transfer flavoprotein DXY21_RS10900 ENOG4105C10 Electron transfer flavoprotein DXY21_RS10905 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXY21_RS10910 ENOG4105K63 Thioredoxin DXY21_RS10915 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DXY21_RS10920 ENOG4105CFH Aspartokinase DXY21_RS10930 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DXY21_RS10940 ENOG4105E33 succinate dehydrogenase DXY21_RS10950 ENOG4105PFC Transcriptional regulator DXY21_RS10955 ENOG41067TZ transcriptional regulator, MarR family DXY21_RS10960 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DXY21_RS10965 ENOG4108XJQ germination protein DXY21_RS10970 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DXY21_RS10975 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DXY21_RS10980 ENOG4105M59 Phosphodiesterase, mj0936 family DXY21_RS11000 ENOG4107SCJ type I restriction enzyme EcoKI subunit R DXY21_RS11010 ENOG4107XZC Restriction modification system DNA (Specificity DXY21_RS11030 ENOG4105C7K acetolactate synthase DXY21_RS11035 ENOG4108ZP8 Acetolactate synthase small subunit DXY21_RS11040 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DXY21_RS11050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXY21_RS11055 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXY21_RS11060 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXY21_RS11070 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DXY21_RS11075 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DXY21_RS11080 ENOG4108IUQ atp-dependent protease DXY21_RS11085 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DXY21_RS11090 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DXY21_RS11100 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DXY21_RS11110 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DXY21_RS11120 ENOG4105D52 delta-aminolevulinic acid dehydratase DXY21_RS11125 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DXY21_RS11130 ENOG41068KH stage VI sporulation protein D DXY21_RS11135 ENOG4106AR7 Spore coat protein DXY21_RS11145 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DXY21_RS11150 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DXY21_RS11155 ENOG4106A3R peptidase DXY21_RS11165 ENOG4108Z03 MAF-like protein DXY21_RS11170 ENOG4105W5Q DNA repair protein (RadC DXY21_RS11175 ENOG4105DFF Rod shape-determining protein mreb DXY21_RS11180 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DXY21_RS11185 ENOG4105YHC Rod shape-determining protein MreD DXY21_RS11190 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DXY21_RS11195 ENOG4107QMS site-determining protein DXY21_RS11210 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DXY21_RS11215 ENOG4105X36 (ribosomal) protein DXY21_RS11220 ENOG4105K46 50S ribosomal protein l27 DXY21_RS11230 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DXY21_RS11240 ENOG4105CQC Prephenate dehydratase DXY21_RS11255 ENOG4108IYU L-aspartate oxidase DXY21_RS11260 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DXY21_RS11265 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DXY21_RS11270 ENOG4106678 morphogenetic protein associated with SpoVID DXY21_RS11290 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DXY21_RS11295 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DXY21_RS11300 ENOG41061AI Protein of unknown function (DUF2905) DXY21_RS11305 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DXY21_RS11310 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DXY21_RS11315 ENOG4105VIE preprotein translocase, subunit YajC DXY21_RS11320 ENOG4105NAP DXY21_RS11325 ENOG4108QG2 Membrane DXY21_RS11330 ENOG4105CKP Polysaccharide Biosynthesis Protein DXY21_RS11340 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DXY21_RS11345 ENOG4105NCW Trka-c domain protein DXY21_RS11350 ENOG41067VP Protein of unknown function (DUF1049) DXY21_RS11355 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DXY21_RS11365 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DXY21_RS11370 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DXY21_RS11375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY21_RS11385 ENOG4105CUT histidyl-tRNA synthetase DXY21_RS11390 ENOG4105C9M aspartyl-trna synthetase DXY21_RS11400 ENOG4105CUZ uba thif-type nad fad binding protein DXY21_RS11405 ENOG4105D1H recombination factor protein RarA DXY21_RS11415 ENOG4105C3J Cysteine desulfurase DXY21_RS11420 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DXY21_RS11430 ENOG4105C7H Helicase, RecD TraA family DXY21_RS11440 ENOG41060CR DXY21_RS11450 ENOG4105DRP amino acid AbC transporter DXY21_RS11455 ENOG4105EAD ABC transporter DXY21_RS11460 ENOG4105CT1 (ABC) transporter DXY21_RS11465 ENOG4105CDA abc transporter atp-binding protein DXY21_RS11470 ENOG4105C02 permease DXY21_RS11475 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DXY21_RS11480 ENOG4105VBH UPF0297 protein DXY21_RS11485 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DXY21_RS11495 ENOG4105HHA aminodeoxychorismate lyase DXY21_RS11500 ENOG4108VQJ O-methyltransferase DXY21_RS11505 ENOG4105XYU peptidase (U32 family) DXY21_RS11510 ENOG4105CFP Peptidase U32 DXY21_RS11520 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DXY21_RS11525 ENOG4107XRG penicillin-binding protein DXY21_RS11555 ENOG4105C28 cystathionine DXY21_RS11570 ENOG4108JB9 formate dehydrogenase DXY21_RS11575 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DXY21_RS11580 ENOG4105TMB Formate nitrite transporter DXY21_RS11595 ENOG41082JN Transcriptional regulator DXY21_RS11600 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY21_RS11605 ENOG4105D94 Major Facilitator Superfamily DXY21_RS11610 ENOG4107RSM transcriptional regulator DXY21_RS11615 ENOG4108Z66 YbaK ebsC protein DXY21_RS11630 ENOG4105DM4 PTS System DXY21_RS11635 ENOG4105DG6 mannose-6-phosphate isomerase DXY21_RS11645 ENOG4108HCJ Hydrolase DXY21_RS11650 ENOG4105DQF Hydrolase DXY21_RS11665 ENOG4108U7W acetyltransferase DXY21_RS11675 ENOG4108J8C transporter major facilitator family protein DXY21_RS11685 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DXY21_RS11690 ENOG41086D8 Transcriptional regulator DXY21_RS11705 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS11715 ENOG41080BT SNARE associated Golgi DXY21_RS11735 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DXY21_RS11740 ENOG4105CQW ribosome biogenesis GTPase YqeH DXY21_RS11745 ENOG4105E2X shikimate dehydrogenase DXY21_RS11750 ENOG410812S Rna-binding protein DXY21_RS11755 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DXY21_RS11760 ENOG4108WF2 Metal Dependent Phosphohydrolase DXY21_RS11770 ENOG4108D32 Methyltransferase DXY21_RS11780 ENOG4105KQC Competence protein DXY21_RS11785 ENOG4108UK2 deaminase DXY21_RS11790 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DXY21_RS11805 ENOG4105TQK DNA polymerase iii, delta' subunit DXY21_RS11810 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DXY21_RS11815 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DXY21_RS11820 ENOG4108ZRV stage ii sporulation protein p DXY21_RS11830 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DXY21_RS11835 ENOG4105CSA Coproporphyrinogen iii oxidase DXY21_RS11840 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DXY21_RS11845 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DXY21_RS11850 ENOG4105CFG Acts as a chaperone (By similarity) DXY21_RS11855 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DXY21_RS11860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DXY21_RS11865 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DXY21_RS11870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXY21_RS11885 ENOG4105KTH gatB Yqey DXY21_RS11890 ENOG4105F7J membrane-bound serine protease DXY21_RS11895 ENOG4105DI5 UPF0365 protein DXY21_RS11905 ENOG41068P3 sporulation protein YqfC DXY21_RS11910 ENOG4105EI1 sporulation protein yqfd DXY21_RS11915 ENOG4105C9A Phoh family DXY21_RS11920 ENOG4105CTJ Metal Dependent Phosphohydrolase DXY21_RS11925 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DXY21_RS11930 ENOG4107YR5 Diacylglycerol kinase DXY21_RS11935 ENOG4105KG3 cytidine deaminase DXY21_RS11940 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DXY21_RS11950 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DXY21_RS11955 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DXY21_RS11960 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DXY21_RS11970 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DXY21_RS11975 ENOG4108UPT UPF0178 protein DXY21_RS11980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DXY21_RS11985 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS12000 ENOG4105EGD dinuclear metal center protein, YbgI family DXY21_RS12005 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DXY21_RS12020 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DXY21_RS12025 ENOG41069ZM Protein of unknown function (DUF2624) DXY21_RS12030 ENOG4108JYZ YitT family DXY21_RS12035 ENOG4105N80 Ferric uptake regulator, Fur family DXY21_RS12040 ENOG4108U5J '-nucleotidase DXY21_RS12045 ENOG41063Y9 DXY21_RS12050 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DXY21_RS12065 ENOG4105SXS Protein of unknown function (DUF456) DXY21_RS12070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXY21_RS12080 ENOG4107RF6 penicillin-binding protein DXY21_RS12085 ENOG4105CVA phosphate DXY21_RS12090 ENOG4105C8U phosphate abc transporter DXY21_RS12095 ENOG4105E2Z phosphate ABC transporter (Permease DXY21_RS12100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXY21_RS12105 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXY21_RS12110 ENOG41068DG YceG-like family DXY21_RS12120 ENOG4105WDJ 50S ribosomal protein L33 DXY21_RS12125 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DXY21_RS12170 ENOG4105C5X domain protein DXY21_RS12195 ENOG4105C37 (CBS) domain DXY21_RS12255 ENOG4105VFR signal peptidase DXY21_RS12265 ENOG4108IMY Transcriptional regulator DXY21_RS12280 ENOG4105C0D helicase DXY21_RS12285 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DXY21_RS12295 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DXY21_RS12300 ENOG4105WZW rhodanese family DXY21_RS12305 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DXY21_RS12325 ENOG4105CBJ Metal-dependent enzyme DXY21_RS12335 ENOG4105DC7 peptidase M24 DXY21_RS12340 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DXY21_RS12350 ENOG4105CD2 stage iii sporulation protein aa DXY21_RS12355 ENOG4105KR5 Stage iii sporulation protein DXY21_RS12360 ENOG4108CQH stage III sporulation protein AC DXY21_RS12365 ENOG4105KQ4 Stage iii sporulation protein ad DXY21_RS12375 ENOG410644B Stage III sporulation protein af DXY21_RS12395 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXY21_RS12400 ENOG4108ZSR alkaline shock protein DXY21_RS12405 ENOG4105M7K Involved in the transcription termination process (By similarity) DXY21_RS12410 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DXY21_RS12415 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXY21_RS12420 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXY21_RS12425 ENOG4105CTB Polyprenyl synthetase DXY21_RS12430 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DXY21_RS12435 ENOG4105DX0 Hemolysin A DXY21_RS12440 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DXY21_RS12445 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DXY21_RS12450 ENOG4105S1Z Stage IV sporulation protein B DXY21_RS12455 ENOG4107QQR Sporulation DXY21_RS12460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXY21_RS12475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXY21_RS12495 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY21_RS12500 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXY21_RS12510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DXY21_RS12515 ENOG4105C1G acyl-Coa dehydrogenase DXY21_RS12525 ENOG4105DXD 2-methylcitrate dehydratase DXY21_RS12530 ENOG4105CR4 methylisocitrate lyase DXY21_RS12535 ENOG4106CCJ Protein of unknown function (DUF2627) DXY21_RS12540 ENOG4108JUB Transcriptional regulator DXY21_RS12550 ENOG4107RDP Dehydrogenase DXY21_RS12555 ENOG4105CKM Branched-chain carboxylic acid kinase DXY21_RS12570 ENOG4105CPP Dehydrogenase, E1 component DXY21_RS12575 ENOG4105C7S Dehydrogenase DXY21_RS12580 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DXY21_RS12585 ENOG4108Y6J UPF0403 protein DXY21_RS12590 ENOG4108HW3 (ABC) transporter DXY21_RS12595 ENOG4105E5Q amino acid AbC transporter DXY21_RS12600 ENOG4105CDA abc transporter atp-binding protein DXY21_RS12605 ENOG4108QEG Membrane DXY21_RS12610 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DXY21_RS12620 ENOG4108ZVT methylmalonyl-coA epimerase DXY21_RS12625 ENOG4108HNZ carboxyl transferase DXY21_RS12630 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXY21_RS12635 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) DXY21_RS12645 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY21_RS12650 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DXY21_RS12655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DXY21_RS12660 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DXY21_RS12665 ENOG410861F 50S ribosomal protein L33 DXY21_RS12675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXY21_RS12685 ENOG4108K70 Transcriptional regulator DXY21_RS12690 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DXY21_RS12695 ENOG4107QKG PfaD family DXY21_RS12710 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS12715 ENOG4105CHR reductase DXY21_RS12725 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS12735 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS12740 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS12755 ENOG4106A3M Cytochrome p-450 DXY21_RS12760 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DXY21_RS12765 ENOG4108KQ6 Enoyl-CoA hydratase DXY21_RS12770 ENOG4105II7 pyrroline-5-carboxylate reductase DXY21_RS12775 ENOG41069FQ Metallo-beta-lactamase superfamily DXY21_RS12780 ENOG4108IXY short-chain dehydrogenase reductase DXY21_RS12790 ENOG4105CS9 pantothenic acid kinase DXY21_RS12795 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase DXY21_RS12805 ENOG4105C02 permease DXY21_RS12820 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY21_RS12825 ENOG4108XET gCN5-related N-acetyltransferase DXY21_RS12830 ENOG4105KAC Antibiotic biosynthesis monooxygenase DXY21_RS12835 ENOG4105RHY Pfam:UPF0157 DXY21_RS12840 ENOG4106HZJ DXY21_RS12860 ENOG4105CPC Aldo Keto reductase DXY21_RS12870 ENOG4108YZ4 nudix hydrolase DXY21_RS12880 ENOG4108IMY Transcriptional regulator DXY21_RS12885 ENOG4105HDK L-asparaginase DXY21_RS12890 ENOG4108IJ0 Aspartate ammonia-lyase DXY21_RS12895 ENOG4105DFD Na H antiporter DXY21_RS12915 ENOG4105MZ9 stage II sporulation protein m DXY21_RS12920 ENOG4105I3K Ferric uptake regulator, Fur family DXY21_RS12930 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXY21_RS12935 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DXY21_RS12940 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DXY21_RS12945 ENOG4105DZ1 carboxypeptidase DXY21_RS12950 ENOG41082AN stage II sporulation protein DXY21_RS12955 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXY21_RS12960 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS12975 ENOG41090VF Stage v sporulation protein ac DXY21_RS12980 ENOG4105CZ3 stage V sporulation protein ad DXY21_RS12990 ENOG4105G6R Stage v sporulation protein ae DXY21_RS13000 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DXY21_RS13005 ENOG4105PTM secreted protein DXY21_RS13010 ENOG4107ZE5 PPIases accelerate the folding of proteins DXY21_RS13035 ENOG4108R6K riboflavin synthase, subunit alpha DXY21_RS13040 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DXY21_RS13045 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DXY21_RS13065 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DXY21_RS13070 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DXY21_RS13080 ENOG4105DZ1 carboxypeptidase DXY21_RS13085 ENOG4108JIC nucleoside recognition domain protein DXY21_RS13095 ENOG4105FE9 pseudouridine synthase DXY21_RS13105 ENOG4107TWT Cytochrome c biogenesis protein DXY21_RS13110 ENOG4105CRE cytochrome C DXY21_RS13115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY21_RS13120 ENOG4105BZU Histidine kinase DXY21_RS13135 ENOG4108JQ1 Dehydrogenase DXY21_RS13140 ENOG4108SAX Membrane DXY21_RS13150 ENOG4105T7X DXY21_RS13155 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY21_RS13160 ENOG4105I7S Abortive infection protein DXY21_RS13175 ENOG4107RGJ metallophosphoesterase DXY21_RS13190 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DXY21_RS13195 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DXY21_RS13205 ENOG4105MSI germination protein ypeb DXY21_RS13220 ENOG4105CAT Cytidine monophosphate kinase DXY21_RS13225 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DXY21_RS13245 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DXY21_RS13250 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DXY21_RS13265 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DXY21_RS13270 ENOG4105K70 DNA-binding protein DXY21_RS13275 ENOG4105EUJ GTP cyclohydrolase i DXY21_RS13280 ENOG4105WP2 Tryptophan RNA-binding attenuator protein DXY21_RS13285 ENOG4105XXQ heptaprenyl diphosphate synthase component I DXY21_RS13290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DXY21_RS13295 ENOG4105EAH synthase DXY21_RS13300 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DXY21_RS13305 ENOG4105BZU Histidine kinase DXY21_RS13310 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DXY21_RS13320 ENOG4105KHN chorismate mutase DXY21_RS13325 ENOG4105CRQ synthase (Component I) DXY21_RS13335 ENOG4105DK0 Indole-3-glycerol phosphate synthase DXY21_RS13340 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DXY21_RS13345 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DXY21_RS13355 ENOG4105CIH Imidazole acetol-phosphate transaminase DXY21_RS13365 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DXY21_RS13370 ENOG41068YB TPR repeat-containing protein DXY21_RS13390 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DXY21_RS13410 ENOG4105F0F Oxalate decarboxylase DXY21_RS13415 ENOG4108JYZ YitT family DXY21_RS13420 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DXY21_RS13425 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DXY21_RS13430 ENOG4108Z5K methylglyoxal synthase DXY21_RS13435 ENOG4105FJR Lmbe family DXY21_RS13440 ENOG4105CPK Glycosyl transferase (Group 1 DXY21_RS13445 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DXY21_RS13455 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DXY21_RS13465 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DXY21_RS13470 ENOG4105DVT helicase DXY21_RS13475 ENOG4105YAC DXY21_RS13485 ENOG4105CHM Aminotransferase DXY21_RS13490 ENOG4105C5S asparaginyl-tRNA synthetase DXY21_RS13500 ENOG4105CSM endonuclease III DXY21_RS13510 ENOG4105BZ4 penicillin-binding protein DXY21_RS13515 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DXY21_RS13560 ENOG4108I5C dEAD DEAH box helicase DXY21_RS13565 ENOG4107X2U Inherit from COG: Exonuclease-like protein DXY21_RS13580 ENOG4108UKS UPF0398 protein DXY21_RS13585 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DXY21_RS13595 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DXY21_RS13610 ENOG4105DVT helicase DXY21_RS13615 ENOG4105CTD carboxy-peptidase DXY21_RS13620 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DXY21_RS13625 ENOG4105C2W permease DXY21_RS13660 ENOG41065KQ synthase DXY21_RS13675 ENOG410890F Dynamin family DXY21_RS13700 ENOG41081VK Ribonuclease DXY21_RS13745 ENOG4105CVG Homoserine O-transsuccinylase DXY21_RS13750 ENOG4108V06 Glutathione peroxidase DXY21_RS13765 ENOG4105C01 Dihydroxy-acid dehydratase DXY21_RS13770 ENOG4108Y6J UPF0403 protein DXY21_RS13775 ENOG4107YX5 Pfam:DUF548 DXY21_RS13785 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DXY21_RS13790 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DXY21_RS13800 ENOG4108UT2 hemolysin iii DXY21_RS13810 ENOG4105C7B Threonine dehydratase DXY21_RS13820 ENOG4108KF3 Electron transport protein SCO1 SenC DXY21_RS13825 ENOG41090WU lipolytic protein G-D-S-L family DXY21_RS13830 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) DXY21_RS13840 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DXY21_RS13845 ENOG4105E0X reductase DXY21_RS13870 ENOG4107Y9E nuclease DXY21_RS13895 ENOG4105BZU Histidine kinase DXY21_RS13900 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS13915 ENOG4105EKQ RNA-directed DNA polymerase DXY21_RS14005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY21_RS14020 ENOG4107S4Y M20 DapE family protein YgeY DXY21_RS14025 ENOG4108TSC N-acetyltransferase DXY21_RS14030 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DXY21_RS14040 ENOG4107Y9E nuclease DXY21_RS14055 ENOG4106BHF DXY21_RS14075 ENOG4108YTE sporulation protein YunB DXY21_RS14085 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY21_RS14110 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY21_RS14140 ENOG4105E4C Lytic transglycosylase catalytic DXY21_RS14185 ENOG41068G1 DXY21_RS14290 ENOG4105K70 DNA-binding protein DXY21_RS14295 ENOG4105ZUG DXY21_RS14325 ENOG4108NE4 DXY21_RS14385 ENOG4107NTZ DXY21_RS14450 ENOG4107D0N DXY21_RS14565 ENOG4108J9Q DNA ligase DXY21_RS14570 ENOG4108RAV Conserved protein DXY21_RS14595 ENOG4105K7W phage-related replication protein DXY21_RS14615 ENOG4106YR8 DXY21_RS14620 ENOG41088HM DXY21_RS14630 ENOG4106PTB DnaB-like helicase C terminal domain DXY21_RS14635 ENOG4106IVX DXY21_RS14645 ENOG4106J9J DNA polymerase DXY21_RS14770 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DXY21_RS14775 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY21_RS14805 ENOG4106ITI Glutaredoxin DXY21_RS14810 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DXY21_RS14845 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DXY21_RS14920 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DXY21_RS14925 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DXY21_RS14965 ENOG410841Q phosphoesterase PA-phosphatase related protein DXY21_RS14970 ENOG4106Z5R DXY21_RS14980 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DXY21_RS14985 ENOG4108VXD carboxy-peptidase DXY21_RS15005 ENOG4108S3Y transcriptional regulator DXY21_RS15010 ENOG4105CS2 ec 3.2.1.21 DXY21_RS15020 ENOG4105E1V na solute symporter DXY21_RS15035 ENOG4105FBA Phospholipase Carboxylesterase DXY21_RS15055 ENOG41090U3 tautomerase DXY21_RS15070 ENOG4105FR1 rard protein DXY21_RS15090 ENOG4106SCS STAS domain DXY21_RS15095 ENOG4107QMU Mate efflux family protein DXY21_RS15105 ENOG41087PP glycosyltransferase MGT family DXY21_RS15110 ENOG4105K4H Nlp p60 protein DXY21_RS15120 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DXY21_RS15125 ENOG4107T89 von Willebrand factor, type A DXY21_RS15130 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DXY21_RS15135 ENOG4105C7S Dehydrogenase DXY21_RS15145 ENOG4105C09 Bile acid DXY21_RS15150 ENOG4105C8J )-transporter DXY21_RS15155 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXY21_RS15160 ENOG4105EWU Squalene--hopene cyclase DXY21_RS15165 ENOG4105C26 Dehydrogenase DXY21_RS15210 ENOG4105SCY DNAK suppressor DXY21_RS15215 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXY21_RS15225 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY21_RS15230 ENOG41069ER domain protein DXY21_RS15255 ENOG4108SJC Membrane DXY21_RS15265 ENOG4105KTU Transcriptional regulator, arsr family DXY21_RS15275 ENOG4108W8B Beta-lactamase domain protein DXY21_RS15290 ENOG4108Z7R Chaperone CsaA DXY21_RS15300 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DXY21_RS15320 ENOG4108J2R molybdopterin oxidoreductase DXY21_RS15325 ENOG4108M3J Dehydrogenase DXY21_RS15330 ENOG4107U6E carbohydrate kinase FGGY DXY21_RS15335 ENOG4105IE8 Alpha-ketoglutarate permease DXY21_RS15340 ENOG4108UB7 DXY21_RS15365 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXY21_RS15370 ENOG4105C5Q Transcriptional regulator DXY21_RS15375 ENOG4105CBC glutamate synthase DXY21_RS15380 ENOG4105BZ8 glutamate synthase DXY21_RS15385 ENOG4105CB2 alcohol dehydrogenase DXY21_RS15390 ENOG4108KSA LysR family transcriptional regulator DXY21_RS15395 ENOG4105C22 threonyL-tRNA synthetase DXY21_RS15400 ENOG4105WAB arsR family transcriptional regulator DXY21_RS15405 ENOG4108RWP Major Facilitator Superfamily protein DXY21_RS15410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXY21_RS15435 ENOG4107QJQ Mate efflux family protein DXY21_RS15440 ENOG4108N2V aldose 1-epimerase DXY21_RS15445 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DXY21_RS15450 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS15460 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS15465 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS15475 ENOG4106U2H Protein of unknown function (DUF1360) DXY21_RS15480 ENOG4105F32 YngK protein DXY21_RS15485 ENOG4105C1G acyl-Coa dehydrogenase DXY21_RS15490 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS15495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXY21_RS15500 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DXY21_RS15505 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DXY21_RS15510 ENOG4105E39 Enoyl-CoA hydratase DXY21_RS15515 ENOG4107QX3 carboxylase DXY21_RS15520 ENOG4107T5V SNARE associated Golgi DXY21_RS15525 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXY21_RS15535 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) DXY21_RS15540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY21_RS15545 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXY21_RS15550 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DXY21_RS15555 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DXY21_RS15560 ENOG4106A3M Cytochrome p-450 DXY21_RS15565 ENOG4105CY2 Citrate transporter DXY21_RS15570 ENOG4105D6N CoA-transferase, subunit a DXY21_RS15575 ENOG4108IIH CoA-transferase subunit B DXY21_RS15580 ENOG4105DTD Dehydrogenase DXY21_RS15605 ENOG4107SYN Glycosyl hydrolases family 43 DXY21_RS15615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY21_RS15640 ENOG4105FVX DXY21_RS15655 ENOG4108I5G Major Facilitator superfamily DXY21_RS15665 ENOG4105DMW Dehydrogenase reductase DXY21_RS15670 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DXY21_RS15675 ENOG4108UHU Aldolase DXY21_RS15680 ENOG4105CPQ Dehydrogenase DXY21_RS15705 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY21_RS15710 ENOG4105K4P CoA-binding domain protein DXY21_RS15715 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DXY21_RS15720 ENOG4105W8X HesB YadR YfhF-family protein DXY21_RS15725 ENOG4105MI2 DXY21_RS15735 ENOG41067CD Small, acid-soluble spore protein Tlp DXY21_RS15750 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY21_RS15755 ENOG4108I0Z Aconitate hydratase DXY21_RS15790 ENOG4107QIV Cytochrome c biogenesis protein DXY21_RS15800 ENOG4105VXM UPF0154 protein DXY21_RS15810 ENOG4105CV1 Transketolase (EC 2.2.1.1) DXY21_RS15815 ENOG4105VPS UPF0291 protein DXY21_RS15820 ENOG4108SVB resolvase DXY21_RS15830 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DXY21_RS15850 ENOG4105K7W phage-related replication protein DXY21_RS15855 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DXY21_RS15885 ENOG4108M1A Chitin-binding protein DXY21_RS15915 ENOG4105DQ4 alcohol dehydrogenase DXY21_RS15935 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DXY21_RS15940 ENOG4105CMG Carbohydrate kinase DXY21_RS15945 ENOG4105C93 Xylose Isomerase DXY21_RS15955 ENOG4105DSG hydrolase family 43 DXY21_RS15960 ENOG4105CT4 transporter DXY21_RS15970 ENOG4105C5F glutamine synthetase DXY21_RS15975 ENOG4105KV4 Transcriptional regulator DXY21_RS15980 ENOG4105CXI aluminum resistance protein DXY21_RS15985 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DXY21_RS15990 ENOG4106F1P AAA ATPase, central domain protein DXY21_RS16000 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY21_RS16005 ENOG4105U6W MutT NUDIX family protein DXY21_RS16010 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY21_RS16015 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY21_RS16040 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DXY21_RS16065 ENOG4108X3M OsmC Ohr family protein DXY21_RS16070 ENOG4105K7W phage-related replication protein DXY21_RS16080 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY21_RS16090 ENOG4105XPP Protein of unknown function (DUF1275) DXY21_RS16095 ENOG4105WFK nuclease DXY21_RS16100 ENOG4106A3M Cytochrome p-450 DXY21_RS16110 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS16120 ENOG4107SQU synthase DXY21_RS16125 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS16130 ENOG4108KQ6 Enoyl-CoA hydratase DXY21_RS16135 ENOG4108MGH Enoyl-CoA hydratase DXY21_RS16140 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DXY21_RS16145 ENOG41062T2 Acyl carrier protein DXY21_RS16150 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY21_RS16155 ENOG4108JA1 polyketide synthase DXY21_RS16160 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY21_RS16165 ENOG4108151 Beta-lactamase domain protein DXY21_RS16175 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DXY21_RS16195 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXY21_RS16200 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXY21_RS16205 ENOG4105CPQ Dehydrogenase DXY21_RS16210 ENOG4105MCT stage V sporulation protein S DXY21_RS16215 ENOG4105D48 metallophosphoesterase DXY21_RS16225 ENOG4108A04 Beta-lactamase DXY21_RS16230 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DXY21_RS16235 ENOG4105CEV competence damage-inducible protein DXY21_RS16240 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DXY21_RS16255 ENOG4105XZV Protein of unknown function (DUF3243) DXY21_RS16260 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DXY21_RS16275 ENOG4105EYF MMPL domain protein DXY21_RS16290 ENOG4105FDP GntR family transcriptional regulator DXY21_RS16295 ENOG4105CNU cell division protein FtsK DXY21_RS16305 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DXY21_RS16315 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DXY21_RS16325 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DXY21_RS16330 ENOG4108S0H Dipicolinic acid synthetase, b subunit DXY21_RS16335 ENOG4105E35 Dipicolinate synthase subunit A DXY21_RS16345 ENOG4105C1V Peptidase, M16 DXY21_RS16355 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DXY21_RS16360 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DXY21_RS16365 ENOG4105DTN riboflavin biosynthesis protein ribF DXY21_RS16370 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DXY21_RS16375 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DXY21_RS16380 ENOG4105W7A Protein of unknown function (DUF503) DXY21_RS16385 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DXY21_RS16390 ENOG4105VHM ribosomal protein DXY21_RS16395 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DXY21_RS16400 ENOG4105CHV Transcription elongation factor NusA DXY21_RS16405 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DXY21_RS16410 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DXY21_RS16415 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DXY21_RS16420 ENOG4105DZP Membrane-associated zinc metalloprotease DXY21_RS16430 ENOG4105KNE Phosphatidate cytidylyltransferase DXY21_RS16435 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DXY21_RS16440 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DXY21_RS16445 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DXY21_RS16455 ENOG4105CE9 30S ribosomal protein S2 DXY21_RS16465 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS16470 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DXY21_RS16480 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DXY21_RS16485 ENOG4105CBS Chea signal transduction histidine kinase DXY21_RS16490 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DXY21_RS16500 ENOG4105FZW flagellar biosynthesis regulator FlhF DXY21_RS16505 ENOG4105D7B Flagellar biosynthesis protein flha DXY21_RS16510 ENOG4105D00 flagellar biosynthetic protein flhB DXY21_RS16515 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DXY21_RS16520 ENOG4105VS8 Flagellar biosynthetic protein fliq DXY21_RS16525 ENOG4105CN7 Flagellar biosynthetic protein FliP DXY21_RS16535 ENOG4107YTP response regulator receiver protein DXY21_RS16540 ENOG4105DD5 Flagellar motor switch protein DXY21_RS16545 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXY21_RS16555 ENOG41068WV flagellar FlbD family protein DXY21_RS16560 ENOG4108JQA flagellar DXY21_RS16565 ENOG410822I Flagellar hook capping protein DXY21_RS16570 ENOG410696Y Flagellar hook-length control protein DXY21_RS16580 ENOG4106YF4 Flagellar biosynthesis chaperone DXY21_RS16595 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXY21_RS16600 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DXY21_RS16605 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DXY21_RS16610 ENOG4108ZC9 flagellar basal-body rod protein flgc DXY21_RS16615 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DXY21_RS16625 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DXY21_RS16630 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DXY21_RS16635 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXY21_RS16640 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DXY21_RS16645 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DXY21_RS16650 ENOG4105C79 DNA protecting protein DprA DXY21_RS16655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DXY21_RS16660 ENOG4105CMV Succinyl-CoA synthetase subunit beta DXY21_RS16665 ENOG4105VM1 flagellar DXY21_RS16675 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXY21_RS16680 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DXY21_RS16685 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DXY21_RS16690 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DXY21_RS16705 ENOG4108BW8 UPF0109 protein DXY21_RS16710 ENOG4105K5M 30s ribosomal protein S16 DXY21_RS16720 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DXY21_RS16730 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DXY21_RS16735 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DXY21_RS16740 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DXY21_RS16745 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DXY21_RS16750 ENOG4105CHR reductase DXY21_RS16755 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY21_RS16760 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DXY21_RS16765 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DXY21_RS16770 ENOG4105CB5 ATP-dependent DNA helicase recG DXY21_RS16775 ENOG4105EJQ L-serine dehydratase DXY21_RS16785 ENOG4105DP4 dak2 domain fusion protein ylov DXY21_RS16790 ENOG4108ZAA Alkaline-shock protein DXY21_RS16795 ENOG4105VB9 50S ribosomal protein l28 DXY21_RS16805 ENOG4105FJ0 thiamine DXY21_RS16810 ENOG4105DJV ribulose-phosphate 3-epimerase DXY21_RS16815 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DXY21_RS16820 ENOG4105D9P serine threonine protein kinase DXY21_RS16825 ENOG4108ZF3 Phosphatase DXY21_RS16830 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DXY21_RS16835 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DXY21_RS16840 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DXY21_RS16845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXY21_RS16850 ENOG4105C25 Primosomal protein n' DXY21_RS16855 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DXY21_RS16865 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DXY21_RS16870 ENOG4105KC4 UPF0296 protein DXY21_RS16875 ENOG4105DSJ YicC domain protein DXY21_RS16885 ENOG4105F23 Fibronectin-binding protein DXY21_RS16890 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DXY21_RS16895 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DXY21_RS16900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXY21_RS16910 ENOG4107RIQ Sulfate adenylate transferase DXY21_RS16925 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DXY21_RS16930 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DXY21_RS16935 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DXY21_RS16940 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DXY21_RS16945 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DXY21_RS16950 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXY21_RS16960 ENOG4105CXT aspartate transcarbamylase DXY21_RS16970 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DXY21_RS16975 ENOG4105C34 Pseudouridine synthase DXY21_RS16980 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DXY21_RS16990 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DXY21_RS17000 ENOG4105DBK s4 domain protein DXY21_RS17005 ENOG41067XK integral membrane protein DXY21_RS17010 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DXY21_RS17015 ENOG4105DFA alanine racemase domain protein DXY21_RS17020 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DXY21_RS17025 ENOG4105WR5 sporulation protein, YlmC YmxH family DXY21_RS17035 ENOG4105DKW ABC transporter DXY21_RS17045 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY21_RS17050 ENOG4105FFI sigma-e processing peptidase spoiiga DXY21_RS17060 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DXY21_RS17065 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DXY21_RS17070 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DXY21_RS17075 ENOG4105D4A Cell wall formation (By similarity) DXY21_RS17080 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DXY21_RS17085 ENOG4105CNI cell division protein FtsW DXY21_RS17090 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DXY21_RS17095 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DXY21_RS17100 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DXY21_RS17105 ENOG4105CJN penicillin-binding protein DXY21_RS17110 ENOG4105CJN penicillin-binding protein DXY21_RS17120 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DXY21_RS17125 ENOG4108V6E Cell division protein mraZ DXY21_RS17150 ENOG41067VY 50S ribosomal protein L32 DXY21_RS17155 ENOG4105KNH Nucleic acid-binding protein DXY21_RS17160 ENOG4105CDE UPF0348 protein DXY21_RS17165 ENOG41063PX domain protein DXY21_RS17170 ENOG4105D78 K07001 NTE family protein DXY21_RS17175 ENOG4105H20 Sporulation integral membrane protein YlbJ DXY21_RS17180 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DXY21_RS17185 ENOG4106H78 methyltransferase DXY21_RS17215 ENOG4106UY4 Inherit from COG: Scp-like extracellular DXY21_RS17220 ENOG41080XQ Signal transduction protein with cbs domains DXY21_RS17235 ENOG41064X9 cytochrome C oxidase subunit IV DXY21_RS17240 ENOG4105CCU oxidase (Subunit III) DXY21_RS17245 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXY21_RS17255 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXY21_RS17265 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DXY21_RS17270 ENOG4105CNI cell division protein FtsW DXY21_RS17280 ENOG4105CSV Glutaminase DXY21_RS17290 ENOG4108IAB Phoh family DXY21_RS17305 ENOG4105QA2 DXY21_RS17310 ENOG4105CI3 gtp-binding protein typa DXY21_RS17345 ENOG4105D4Y metalloprotease DXY21_RS17355 ENOG4105ECY inositol monophosphatase DXY21_RS17370 ENOG4105WBI UPF0223 protein DXY21_RS17375 ENOG4105CXN decarboxylase DXY21_RS17395 ENOG4107QN2 dihydrolipoyl dehydrogenase DXY21_RS17400 ENOG4105C7S Dehydrogenase DXY21_RS17405 ENOG4105CPP Dehydrogenase, E1 component DXY21_RS17415 ENOG4105FQP Beta-lactamase DXY21_RS17420 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS17425 ENOG4107SQU synthase DXY21_RS17430 ENOG4107SQU synthase DXY21_RS17435 ENOG4107SQU synthase DXY21_RS17440 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS17445 ENOG4107SQU synthase DXY21_RS17450 ENOG4105C0W non-ribosomal peptide synthetase DXY21_RS17455 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY21_RS17470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXY21_RS17475 ENOG4108X4Q Hydrolase DXY21_RS17480 ENOG4106148 UPF0356 protein DXY21_RS17485 ENOG4105CN5 Metallo-Beta-Lactamase DXY21_RS17490 ENOG4105CPN adenine deaminase DXY21_RS17495 ENOG4107ZYR domain protein DXY21_RS17505 ENOG4105BZU Histidine kinase DXY21_RS17530 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DXY21_RS17535 ENOG4105C5H ABC transporter DXY21_RS17550 ENOG4105DM4 PTS System DXY21_RS17555 ENOG4105DE4 1-phosphofructokinase DXY21_RS17560 ENOG4105E98 transcriptional regulator DeoR family DXY21_RS17565 ENOG4107RBB ABC transporter, permease DXY21_RS17570 ENOG4105C19 ABC transporter DXY21_RS17575 ENOG4107X8C Efflux transporter RND family MFP subunit DXY21_RS17585 ENOG41067WU Molybdopterin converting factor (Subunit 1) DXY21_RS17590 ENOG4108ZAF Molybdopterin DXY21_RS17595 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DXY21_RS17600 ENOG4105CVM Molybdenum cofactor synthesis domain protein DXY21_RS17605 ENOG4105D06 uba thif-type nad fad binding protein DXY21_RS17610 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DXY21_RS17625 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY21_RS17630 ENOG4105D8X mechanosensitive ion channel DXY21_RS17650 ENOG4105NQC Flavodoxin DXY21_RS17680 ENOG4108XRC Protein of unknown function (DUF458) DXY21_RS17685 ENOG4107IN1 Protein of unknown function (DUF1797) DXY21_RS17690 ENOG4105EPM Diguanylate phosphodiesterase DXY21_RS17705 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DXY21_RS17715 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DXY21_RS17725 ENOG4105UIN DXY21_RS17730 ENOG4107R88 Chemotaxis protein (CheV) DXY21_RS17735 ENOG4105CHM Aminotransferase DXY21_RS17740 ENOG4105BZU Histidine kinase DXY21_RS17750 ENOG4105K4I Scp-like extracellular DXY21_RS17755 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DXY21_RS17760 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DXY21_RS17765 ENOG4105F6S Spore photoproduct lyase DXY21_RS17775 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DXY21_RS17780 ENOG4105KRI phosphocarrier protein (HPr DXY21_RS17790 ENOG4105CID antiterminator DXY21_RS17800 ENOG4105DC7 peptidase M24 DXY21_RS17805 ENOG4105C59 p-type ATPase DXY21_RS17820 ENOG4105F0V Cell wall hydrolase DXY21_RS17840 ENOG4105CB5 ATP-dependent DNA helicase recG DXY21_RS17850 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DXY21_RS17860 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DXY21_RS17865 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DXY21_RS17870 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DXY21_RS17875 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DXY21_RS17885 ENOG4108K88 Membrane DXY21_RS17895 ENOG4105E14 MotA TolQ exbB proton channel DXY21_RS17900 ENOG4105ER2 Ompa motb domain protein DXY21_RS17905 ENOG41090MY MarR family Transcriptional regulator DXY21_RS17910 ENOG4105BZU Histidine kinase DXY21_RS17920 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DXY21_RS17925 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DXY21_RS17930 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DXY21_RS17935 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DXY21_RS17945 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXY21_RS17955 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DXY21_RS17960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXY21_RS17965 ENOG4105BZU Histidine kinase DXY21_RS17970 ENOG4108TGC Acyltransferase DXY21_RS17980 ENOG410900G Protein of unknown function (DUF421) DXY21_RS17990 ENOG4105D0M Protease HtpX homolog DXY21_RS18000 ENOG410681C small acid-soluble spore protein DXY21_RS18010 ENOG4108WZW RNA polymerase sigma DXY21_RS18015 ENOG4107TS3 membrane protein, TerC DXY21_RS18020 ENOG4107T5V SNARE associated Golgi DXY21_RS18025 ENOG4105FDF Could be involved in DNA repair (By similarity) DXY21_RS18030 ENOG4105DQE DNA ligase DXY21_RS18055 ENOG4105V75 Transcriptional regulator DXY21_RS18060 ENOG4105CJW magnesium transporter DXY21_RS18075 ENOG4105VRS hydrolase family 18 DXY21_RS18080 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DXY21_RS18085 ENOG4108JJB ABC transporter DXY21_RS18090 ENOG4108W7F transporter, permease DXY21_RS18100 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY21_RS18105 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DXY21_RS18110 ENOG4108Y4K DNA-binding transcriptional activator DXY21_RS18115 ENOG4105D8G Major Facilitator superfamily DXY21_RS18125 ENOG4107TVC Glycosyl transferase, family 2 DXY21_RS18140 ENOG4108ZHJ Organic hydroperoxide resistance protein DXY21_RS18145 ENOG4105K56 Transcriptional regulator DXY21_RS18160 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXY21_RS18165 ENOG4105CIY formyltetrahydrofolate deformylase DXY21_RS18170 ENOG41080TC multidrug resistance protein DXY21_RS18180 ENOG4108428 Inherit from COG: -acetyltransferase DXY21_RS18185 ENOG4108S4H thioesterase Superfamily protein DXY21_RS18190 ENOG4107TUM Amidinotransferase DXY21_RS18195 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DXY21_RS18200 ENOG4108JQ7 (ABC) transporter DXY21_RS18205 ENOG4107SN7 NLP P60 protein DXY21_RS18210 ENOG4105DTQ mandelate racemase muconate lactonizing DXY21_RS18215 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DXY21_RS18225 ENOG4105C3U ABC transporter DXY21_RS18230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY21_RS18235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXY21_RS18240 ENOG4108ME1 Peptidase M55 D-aminopeptidase DXY21_RS18250 ENOG4105C0H protease DXY21_RS18255 ENOG4105CKK Glycosyl transferase, family 2 DXY21_RS18260 ENOG4105EDW glycosyl transferase, family 39 DXY21_RS18270 ENOG4107R7I amino acid DXY21_RS18275 ENOG4107GRR phosphate transport regulator DXY21_RS18280 ENOG4105CJ3 phosphate transporter DXY21_RS18295 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXY21_RS18325 ENOG41068G1 DXY21_RS18335 ENOG410906S phage-like element pbsx protein xkdt DXY21_RS18340 ENOG41066EA baseplate J family protein DXY21_RS18345 ENOG4105MFU Protein of unknown function (DUF2634) DXY21_RS18355 ENOG4105X7F DXY21_RS18360 ENOG4108WZM domain protein DXY21_RS18365 ENOG4108FKH Transglycosylase SLT domain DXY21_RS18365 ENOG4108FKH Transglycosylase SLT domain DXY21_RS18365 ENOG4108FKH Transglycosylase SLT domain DXY21_RS18375 ENOG4105MTC XkdN-like protein DXY21_RS18380 ENOG4105FR7 XkdM protein, phage-like element PBSX DXY21_RS18385 ENOG4105PQS phage protein DXY21_RS18400 ENOG41060SN DXY21_RS18425 ENOG4108MDF Phage Portal Protein DXY21_RS18430 ENOG4105IG6 Phage terminase, large subunit DXY21_RS18435 ENOG4108TFU terminase (Small subunit) DXY21_RS18475 ENOG410635T phage-like element pbsx protein DXY21_RS18480 ENOG4105K7W phage-related replication protein DXY21_RS18485 ENOG4105KWG Pfam:DUF1696 DXY21_RS18490 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY21_RS18510 ENOG4107TSN permease DXY21_RS18520 ENOG4108JJA ABC, transporter DXY21_RS18535 ENOG4105WH1 Two component transcriptional regulator luxr family DXY21_RS18540 ENOG4105BZU Histidine kinase DXY21_RS18560 ENOG4105F3H Histidine kinase DXY21_RS18565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY21_RS18570 ENOG4105CTX dehydratase DXY21_RS18575 ENOG4107QZW Altronate oxidoreductase DXY21_RS18580 ENOG4107KJX Transcriptional regulator DXY21_RS18585 ENOG4105CT4 transporter DXY21_RS18590 ENOG4105D2H Uronic isomerase DXY21_RS18605 ENOG4105Q95 Cupin 2, conserved barrel domain protein DXY21_RS18615 ENOG4108IXI (ABC) transporter DXY21_RS18620 ENOG4105C4B ABC transporter, permease DXY21_RS18625 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DXY21_RS18635 ENOG41087PP glycosyltransferase MGT family DXY21_RS18640 ENOG4106A3M Cytochrome p-450 DXY21_RS18650 ENOG4108IEG Formate dehydrogenase Alpha subunit DXY21_RS18675 ENOG4105KT7 mgtC SapB transporter DXY21_RS18690 ENOG4105E98 transcriptional regulator DeoR family DXY21_RS18700 ENOG4105VCP PTS System DXY21_RS18705 ENOG4105CK1 PTS System DXY21_RS18710 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DXY21_RS18715 ENOG4105CMR udp-glucose 4-epimerase DXY21_RS18720 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase DXY21_RS18735 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY21_RS18750 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DXY21_RS18760 ENOG4106BHF DXY21_RS18800 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY21_RS18820 ENOG41068G1 DXY21_RS18835 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DXY21_RS18940 ENOG4107QRS glycosyltransferase group 2 family protein DXY21_RS18950 ENOG4105K7W phage-related replication protein DXY21_RS18995 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the DXY21_RS19020 ENOG41069ER domain protein DXY21_RS19025 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) DXY21_RS19040 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DXY21_RS19050 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY21_RS19075 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DXY21_RS19115 ENOG4105C2M dna polymerase I DXY21_RS19230 ENOG4105C28 cystathionine DXY21_RS19235 ENOG4105C28 cystathionine DXY21_RS19245 ENOG4108ZMI UPF0477 protein DXY21_RS19260 ENOG4105CJ1 ABC, transporter DXY21_RS19280 ENOG4105ENA helicase DXY21_RS19330 ENOG4107A88 DXY21_RS19335 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DXY21_RS19340 ENOG4105DWF phosphomethylpyrimidine kinase DXY21_RS19345 ENOG4105D06 uba thif-type nad fad binding protein DXY21_RS19365 ENOG4108VEU Thiamine monophosphate synthase DXY21_RS19370 ENOG4105ETU transcriptional activator (TenA DXY21_RS19380 ENOG4107S1Q Phosphatase DXY21_RS19385 ENOG4105EMS pseudouridine synthase DXY21_RS19390 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXY21_RS19405 ENOG4105MIX Adenylate cyclase DXY21_RS19410 ENOG4105E4C Lytic transglycosylase catalytic DXY21_RS19415 ENOG4108Z18 K06886 hemoglobin DXY21_RS19420 ENOG4105T58 Dithiol-disulfide isomerase DXY21_RS19425 ENOG4105DPN Oligoendopeptidase f DXY21_RS19435 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DXY21_RS19440 ENOG4108ZCF integral membrane protein DXY21_RS19445 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DXY21_RS19460 ENOG4108JQ7 (ABC) transporter DXY21_RS19470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY21_RS19475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXY21_RS19480 ENOG4108J59 Extracellular solute-binding protein, family 5 DXY21_RS19485 ENOG4105C31 Tryptophanyl-tRNA synthetase DXY21_RS19495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY21_RS19510 ENOG4108JQ7 (ABC) transporter DXY21_RS19515 ENOG4105C3U ABC transporter DXY21_RS19525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DXY21_RS19530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DXY21_RS19545 ENOG4107RMD Basic membrane lipoprotein DXY21_RS19570 ENOG4105DBV ornithine carbamoyltransferase DXY21_RS19580 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXY21_RS19585 ENOG4105C8Y Acetylornithine aminotransferase DXY21_RS19590 ENOG4105CAS nag kinase DXY21_RS19600 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DXY21_RS19610 ENOG4105IQ5 FAD linked oxidase domain protein DXY21_RS19615 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DXY21_RS19620 ENOG4105VG1 fes assembly suf system protein DXY21_RS19625 ENOG4108MXZ Esterase DXY21_RS19630 ENOG4108KP7 hydrolase DXY21_RS19635 ENOG41073B9 DXY21_RS19645 ENOG4107AYK membrAne DXY21_RS19650 ENOG4105EPR degv family DXY21_RS19660 ENOG4105C8Q Methyl-accepting chemotaxis DXY21_RS19665 ENOG4105DIH basic membrane DXY21_RS19670 ENOG4105QNR S1 RNA binding domain protein DXY21_RS19675 ENOG4108VPT UPF0234 protein DXY21_RS19685 ENOG4105MA6 gCN5-related N-acetyltransferase DXY21_RS19690 ENOG4105MYW Pentapeptide repeat protein DXY21_RS19695 ENOG4105SF0 DinB family DXY21_RS19700 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXY21_RS19705 ENOG4105ETE Transcriptional regulator (LacI family DXY21_RS19710 ENOG4106HBX Transcriptional Regulator AraC Family DXY21_RS19715 ENOG4105UQX Mate efflux family protein DXY21_RS19725 ENOG4105CAQ asparagine synthetase DXY21_RS19745 ENOG4105ERH Fumarylacetoacetate hydrolase DXY21_RS19790 ENOG4105EYH Exonuclease DXY21_RS19800 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DXY21_RS19805 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DXY21_RS19810 ENOG4108QY0 Membrane DXY21_RS19820 ENOG4108IG5 Transcriptional regulator DXY21_RS19830 ENOG4108KK1 membrane protein AbrB duplication DXY21_RS19835 ENOG4108INS Transcriptional regulator DXY21_RS19855 ENOG41060YP DXY21_RS19860 ENOG4106CAD Protein of unknown function (DUF3311) DXY21_RS19865 ENOG4105E1V na solute symporter DXY21_RS19870 ENOG4105K8R UPF0145 protein DXY21_RS19875 ENOG4105X3H Excalibur domain protein DXY21_RS19885 ENOG4108ZMX Domain of unknown function (DU1801) DXY21_RS19895 ENOG4105XVF Competence transcription factor DXY21_RS19915 ENOG4106YBV Methyl-accepting chemotaxis DXY21_RS19920 ENOG4107ZYJ bioY protein DXY21_RS19925 ENOG4107F3J Amp-dependent synthetase and ligase DXY21_RS19935 ENOG4107TB6 phosphoglycerate mutase DXY21_RS19940 ENOG4108HUF Transporter DXY21_RS19955 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DXY21_RS19965 ENOG4105CEY Amp-dependent synthetase and ligase DXY21_RS19975 ENOG4105DF9 Lipoate-protein, ligase DXY21_RS19980 ENOG4108RQ5 Beta-lactamase domain-containing protein DXY21_RS19985 ENOG4106AXD DXY21_RS19995 ENOG4105DER m42 family DXY21_RS20010 ENOG4105ECB domain protein DXY21_RS20020 ENOG4105C1Q protoporphyrinogen oxidase DXY21_RS20025 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DXY21_RS20030 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DXY21_RS20035 ENOG4105BZ4 penicillin-binding protein DXY21_RS20040 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DXY21_RS20070 ENOG4105K59 histidine triad (HIT) protein DXY21_RS20075 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DXY21_RS20080 ENOG4105NBU tryptophan transport protein DXY21_RS20125 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DXY21_RS20135 ENOG4105EQI Metal Dependent Phosphohydrolase DXY21_RS20140 ENOG4106D4I domain protein DXY21_RS20145 ENOG4107VRP DNA repair exonuclease DXY21_RS20150 ENOG4105RHA ABC transporter, permease DXY21_RS20155 ENOG4108IUX (ABC) transporter DXY21_RS20165 ENOG4105CGU Enoyl-CoA hydratase DXY21_RS20175 ENOG4105NCW Trka-c domain protein DXY21_RS20180 ENOG4107S91 Sodium hydrogen exchanger DXY21_RS20190 ENOG4105D4P Coproporphyrinogen iii oxidase DXY21_RS20200 ENOG4105F1N DNA alkylation repair DXY21_RS20205 ENOG4105WZB UPF0342 protein DXY21_RS20210 ENOG4106MP8 UPF0754 membrane protein DXY21_RS20220 ENOG410839P DXY21_RS20240 ENOG4105BZ1 (ABC) transporter DXY21_RS20245 ENOG4105BZ1 (ABC) transporter DXY21_RS20255 ENOG4105IIP Membrane DXY21_RS20260 ENOG4105W1N transcriptional regulator DXY21_RS20265 ENOG4105F0I Aminotransferase DXY21_RS20270 ENOG4107VMI polysaccharide deacetylase DXY21_RS20275 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DXY21_RS20280 ENOG4105D64 Mechanosensitive ion channel DXY21_RS20290 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXY21_RS20295 ENOG4105WMR Protein CrcB homolog DXY21_RS20305 ENOG4105C37 (CBS) domain DXY21_RS20310 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DXY21_RS20315 ENOG4105CHM Aminotransferase DXY21_RS20325 ENOG4105C37 (CBS) domain DXY21_RS20330 ENOG4105F6E Acyl-transferase DXY21_RS20335 ENOG4108AEY RNA polymerase sigma factor DXY21_RS20340 ENOG4105J37