locus-tag	class	description
DXY21_RS00010	COG0531	amino acid
DXY21_RS00015	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS00020	COG0372	Belongs to the citrate synthase family
DXY21_RS00025	COG0583	DNA-binding transcription factor activity
DXY21_RS00030	COG1388	LysM domain
DXY21_RS00030	COG0791	NLP P60 protein
DXY21_RS00035	COG1785	Belongs to the alkaline phosphatase family
DXY21_RS00040	COG2719	SpoVR family
DXY21_RS00045	COG0668	transmembrane transport
DXY21_RS00050	COG1959	2 iron, 2 sulfur cluster binding
DXY21_RS00055	COG1388	LysM domain
DXY21_RS00055	COG0791	NLP P60 protein
DXY21_RS00070	COG0431	NADPH-dependent FMN reductase
DXY21_RS00075	COG2197	response regulator
DXY21_RS00080	COG2203	Gaf domain
DXY21_RS00080	COG4585	Histidine kinase
DXY21_RS00085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DXY21_RS00090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DXY21_RS00100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DXY21_RS00105	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DXY21_RS00110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY21_RS00115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY21_RS00115	COG3153	acetyltransferase
DXY21_RS00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DXY21_RS00125	COG0517	IMP dehydrogenase activity
DXY21_RS00135	COG0564	pseudouridine synthase activity
DXY21_RS00140	COG3764	Sortase (surface protein transpeptidase)
DXY21_RS00145	COG4085	toxin activity
DXY21_RS00145	COG1525	nuclease
DXY21_RS00145	COG0737	Belongs to the 5'-nucleotidase family
DXY21_RS00150	COG5577	PFAM Coat F domain
DXY21_RS00170	COG1823	symporter activity
DXY21_RS00180	COG1464	Belongs to the NlpA lipoprotein family
DXY21_RS00185	COG1278	Cold shock
DXY21_RS00190	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY21_RS00195	COG1131	(ABC) transporter
DXY21_RS00200	COG1131	(ABC) transporter
DXY21_RS00205	COG1725	Transcriptional regulator
DXY21_RS00220	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY21_RS00225	COG2814	Major facilitator Superfamily
DXY21_RS00230	COG1566	PFAM secretion protein HlyD family protein
DXY21_RS00235	COG1846	Transcriptional regulator
DXY21_RS00245	COG2766	serine protein kinase
DXY21_RS00250	COG1664	Polymer-forming cytoskeletal
DXY21_RS00255	COG1664	Polymer-forming cytoskeletal
DXY21_RS00260	COG0789	Transcriptional regulator
DXY21_RS00265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DXY21_RS00275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DXY21_RS00280	COG3382	B3 4 domain protein
DXY21_RS00290	COG1476	TRANSCRIPTIONal
DXY21_RS00310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY21_RS00315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY21_RS00320	COG1116	anion transmembrane transporter activity
DXY21_RS00330	COG0753	catalase activity
DXY21_RS00335	COG4608	Belongs to the ABC transporter superfamily
DXY21_RS00340	COG0444	Belongs to the ABC transporter superfamily
DXY21_RS00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY21_RS00350	COG0601	transmembrane transport
DXY21_RS00355	COG0747	negative chemotaxis
DXY21_RS00365	COG0277	FAD linked oxidase domain protein
DXY21_RS00375	COG3340	Belongs to the peptidase S51 family
DXY21_RS00490	COG0735	belongs to the Fur family
DXY21_RS00495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DXY21_RS00505	COG4129	membrane
DXY21_RS00510	COG1132	(ABC) transporter
DXY21_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS00540	COG1194	a g-specific adenine glycosylase
DXY21_RS00545	COG1988	membrane-bound metal-dependent
DXY21_RS00550	COG4485	Bacterial membrane protein, YfhO
DXY21_RS00555	COG0463	Glycosyl transferase, family 2
DXY21_RS00560	COG0596	Alpha beta hydrolase
DXY21_RS00565	COG5658	integral membrane protein
DXY21_RS00570	COG3103	Sh3 type 3 domain protein
DXY21_RS00585	COG3591	Belongs to the peptidase S1B family
DXY21_RS00595	COG2814	Major facilitator Superfamily
DXY21_RS00610	COG1090	epimerase
DXY21_RS00625	COG0778	Nitroreductase
DXY21_RS00630	COG0384	phenazine biosynthesis protein PhzF
DXY21_RS00635	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DXY21_RS00635	COG0392	lysyltransferase activity
DXY21_RS00640	COG1846	Transcriptional regulator
DXY21_RS00645	COG2814	Major facilitator Superfamily
DXY21_RS00650	COG2318	DinB family
DXY21_RS00655	COG2732	(Barnase) inhibitor
DXY21_RS00660	COG0574	Belongs to the PEP-utilizing enzyme family
DXY21_RS00660	COG3848	Pyruvate phosphate dikinase
DXY21_RS00665	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DXY21_RS00670	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY21_RS00675	COG1695	Transcriptional regulator
DXY21_RS00685	COG2514	catechol 2,3-dioxygenase activity
DXY21_RS00690	COG2259	Doxx family
DXY21_RS00695	COG1132	(ABC) transporter
DXY21_RS00700	COG1132	(ABC) transporter
DXY21_RS00705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS00705	COG1263	PTS System
DXY21_RS00710	COG1737	Transcriptional regulator
DXY21_RS00715	COG1486	melibiose metabolic process
DXY21_RS00725	COG3284	Transcriptional regulator
DXY21_RS00730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY21_RS00735	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY21_RS00740	COG0022	dehydrogenase e1 component
DXY21_RS00745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY21_RS00750	COG4637	Psort location Cytoplasmic, score
DXY21_RS00755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY21_RS00765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY21_RS00770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DXY21_RS00775	COG0598	Magnesium transport protein CorA
DXY21_RS00785	COG2084	Dehydrogenase
DXY21_RS00790	COG0726	polysaccharide deacetylase
DXY21_RS00800	COG0535	radical SAM domain protein
DXY21_RS00805	COG0668	transmembrane transport
DXY21_RS00815	COG0387	Pfam Sodium calcium exchanger
DXY21_RS00820	COG0477	Major facilitator Superfamily
DXY21_RS00825	COG1295	ribonuclease BN
DXY21_RS00830	COG4980	gas vesicle protein
DXY21_RS00835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY21_RS00845	COG2814	Major facilitator Superfamily
DXY21_RS00855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DXY21_RS00860	COG1609	Transcriptional regulator
DXY21_RS00865	COG0693	protein deglycase activity
DXY21_RS00870	COG0737	Belongs to the 5'-nucleotidase family
DXY21_RS00885	COG0778	Nitroreductase
DXY21_RS00890	COG2188	Transcriptional regulator
DXY21_RS00895	COG0366	Alpha amylase catalytic
DXY21_RS00900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS00900	COG1263	PTS System
DXY21_RS00915	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY21_RS00925	COG1368	sulfuric ester hydrolase activity
DXY21_RS00935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS00935	COG1263	PTS System
DXY21_RS00940	COG0024	Methionine aminopeptidase
DXY21_RS00960	COG2258	MOSC domain
DXY21_RS00970	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DXY21_RS00975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS00980	COG2851	Citrate transporter
DXY21_RS00985	COG3181	Tripartite tricarboxylate transporter family receptor
DXY21_RS00990	COG4565	transcriptional regulatory protein
DXY21_RS00995	COG3290	protein histidine kinase activity
DXY21_RS01000	COG3764	Sortase (surface protein transpeptidase)
DXY21_RS01010	COG3279	Response regulator of the LytR AlgR family
DXY21_RS01015	COG0745	RESPONSE REGULATOR receiver
DXY21_RS01015	COG2972	Histidine kinase
DXY21_RS01035	COG0471	metal ion transport
DXY21_RS01040	COG3866	Pectate lyase
DXY21_RS01055	COG2130	NADP-dependent
DXY21_RS01065	COG0513	Belongs to the DEAD box helicase family
DXY21_RS01070	COG0488	(ABC) transporter
DXY21_RS01075	COG2814	Major facilitator Superfamily
DXY21_RS01080	COG0789	Transcriptional regulator
DXY21_RS01085	COG0488	(ABC) transporter
DXY21_RS01090	COG0457	Tetratricopeptide repeat
DXY21_RS01090	COG0463	Glycosyl transferase, family 2
DXY21_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS01100	COG0840	transmembrane signaling receptor activity
DXY21_RS01105	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS01110	COG0531	amino acid
DXY21_RS01115	COG2223	nitrite transmembrane transporter activity
DXY21_RS01120	COG1442	glycosyl transferase family 8
DXY21_RS01125	COG1216	Glycosyl transferase, family 2
DXY21_RS01130	COG1442	glycosyl transferase family 8
DXY21_RS01135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS01140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DXY21_RS01145	COG1368	sulfuric ester hydrolase activity
DXY21_RS01150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY21_RS01150	COG2124	cytochrome p450
DXY21_RS01160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DXY21_RS01165	COG1846	Transcriptional regulator
DXY21_RS01175	COG0670	Belongs to the BI1 family
DXY21_RS01180	COG0196	riboflavin kinase activity
DXY21_RS01185	COG5583	Uncharacterized small protein (DUF2292)
DXY21_RS01190	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS01195	COG0346	lactoylglutathione lyase activity
DXY21_RS01200	COG2329	Antibiotic biosynthesis monooxygenase
DXY21_RS01205	COG2323	membrane
DXY21_RS01215	COG0454	-acetyltransferase
DXY21_RS01220	COG3546	catalase activity
DXY21_RS01255	COG5444	nuclease activity
DXY21_RS01280	COG1131	(ABC) transporter
DXY21_RS01290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY21_RS01295	COG1597	lipid kinase activity
DXY21_RS01300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DXY21_RS01305	COG1309	transcriptional regulator
DXY21_RS01325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY21_RS01330	COG1285	pathogenesis
DXY21_RS01335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY21_RS01340	COG4851	CamS sex pheromone cAM373 precursor
DXY21_RS01350	COG0210	DNA helicase
DXY21_RS01365	COG0069	glutamate synthase activity
DXY21_RS01370	COG4496	protein, YerC YecD
DXY21_RS01375	COG1470	cell adhesion involved in biofilm formation
DXY21_RS01380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DXY21_RS01390	COG0151	Belongs to the GarS family
DXY21_RS01395	COG0138	bifunctional purine biosynthesis protein purh
DXY21_RS01400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DXY21_RS01410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DXY21_RS01425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DXY21_RS01430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DXY21_RS01435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DXY21_RS01440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DXY21_RS01445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DXY21_RS01465	COG3064	Membrane
DXY21_RS01470	COG2252	PERMEase
DXY21_RS01490	COG1305	Transglutaminase-like
DXY21_RS01495	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DXY21_RS01500	COG0714	Associated with various cellular activities
DXY21_RS01505	COG1113	amino acid transport
DXY21_RS01510	COG2132	Multicopper oxidase
DXY21_RS01520	COG0823	Involved in the tonB-independent uptake of proteins
DXY21_RS01525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DXY21_RS01530	COG1063	alcohol dehydrogenase
DXY21_RS01535	COG1595	DNA-templated transcription, initiation
DXY21_RS01545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DXY21_RS01545	COG2755	lipolytic protein G-D-S-L family
DXY21_RS01550	COG4260	virion core protein, lumpy skin disease virus
DXY21_RS01555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DXY21_RS01560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY21_RS01565	COG1842	Phage shock protein A
DXY21_RS01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY21_RS01580	COG2211	Major facilitator Superfamily
DXY21_RS01585	COG1063	alcohol dehydrogenase
DXY21_RS01590	COG0457	Tetratricopeptide repeat
DXY21_RS01595	COG0842	Transport permease protein
DXY21_RS01600	COG1131	(ABC) transporter
DXY21_RS01655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DXY21_RS01660	COG1266	CAAX protease self-immunity
DXY21_RS01670	COG0805	protein transport
DXY21_RS01675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY21_RS01690	COG0488	(ABC) transporter
DXY21_RS01695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DXY21_RS01700	COG0456	acetyltransferase
DXY21_RS01705	COG1214	PFAM Peptidase M22, glycoprotease
DXY21_RS01710	COG0802	atpase or kinase
DXY21_RS01715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DXY21_RS01755	COG2814	Major facilitator Superfamily
DXY21_RS01760	COG0604	alcohol dehydrogenase
DXY21_RS01765	COG3832	glyoxalase III activity
DXY21_RS01775	COG0531	amino acid
DXY21_RS01780	COG1309	transcriptional regulator
DXY21_RS01785	COG2076	Multidrug Resistance protein
DXY21_RS01790	COG2076	Multidrug Resistance protein
DXY21_RS01795	COG2807	transmembrane transport
DXY21_RS01800	COG2186	Transcriptional regulator
DXY21_RS01805	COG2188	Transcriptional regulator
DXY21_RS01810	COG2814	Major facilitator Superfamily
DXY21_RS01815	COG1388	LysM domain
DXY21_RS01820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY21_RS01835	COG1819	glycosyl
DXY21_RS01840	COG1802	Transcriptional regulator
DXY21_RS01845	COG0473	3-isopropylmalate dehydrogenase activity
DXY21_RS01850	COG2226	methyltransferase
DXY21_RS01855	COG1051	belongs to the nudix hydrolase family
DXY21_RS01860	COG0697	spore germination
DXY21_RS01865	COG4978	Transcriptional regulator
DXY21_RS01865	COG0789	Transcriptional regulator
DXY21_RS01870	COG0456	acetyltransferase
DXY21_RS01875	COG0730	response to heat
DXY21_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY21_RS01890	COG2814	Major facilitator Superfamily
DXY21_RS01900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS01905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY21_RS01915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DXY21_RS01920	COG2409	Drug exporters of the RND superfamily
DXY21_RS01925	COG2197	response regulator
DXY21_RS01930	COG4585	Histidine kinase
DXY21_RS01940	COG5577	PFAM Coat F domain
DXY21_RS01945	COG1063	alcohol dehydrogenase
DXY21_RS01955	COG5577	PFAM Coat F domain
DXY21_RS01960	COG1309	transcriptional regulator
DXY21_RS01965	COG2814	Major facilitator Superfamily
DXY21_RS01980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY21_RS01990	COG0789	Transcriptional regulator
DXY21_RS01995	COG1064	alcohol dehydrogenase
DXY21_RS02020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DXY21_RS02050	COG0277	FAD linked oxidase domain protein
DXY21_RS02070	COG0477	Major facilitator Superfamily
DXY21_RS02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY21_RS02085	COG1917	Cupin 2, conserved barrel domain protein
DXY21_RS02085	COG2207	Transcriptional regulator
DXY21_RS02090	COG1473	amidohydrolase
DXY21_RS02095	COG0814	amino acid
DXY21_RS02100	COG0251	oxidation-reduction process
DXY21_RS02105	COG1802	Transcriptional regulator
DXY21_RS02110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DXY21_RS02120	COG3621	Patatin-like phospholipase
DXY21_RS02135	COG1794	racemase activity, acting on amino acids and derivatives
DXY21_RS02140	COG0730	response to heat
DXY21_RS02145	COG0425	Belongs to the sulfur carrier protein TusA family
DXY21_RS02150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS02150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY21_RS02155	COG0425	Belongs to the sulfur carrier protein TusA family
DXY21_RS02155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY21_RS02165	COG2210	Belongs to the sulfur carrier protein TusA family
DXY21_RS02170	COG1937	Protein conserved in bacteria
DXY21_RS02180	COG1278	Cold shock
DXY21_RS02185	COG2910	NAD(P)H-binding
DXY21_RS02190	COG1959	2 iron, 2 sulfur cluster binding
DXY21_RS02200	COG1846	Transcriptional regulator
DXY21_RS02205	COG1764	response to oxidative stress
DXY21_RS02215	COG0477	Major facilitator Superfamily
DXY21_RS02220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DXY21_RS02315	COG2183	response to ionizing radiation
DXY21_RS02320	COG2208	phosphoserine phosphatase activity
DXY21_RS02325	COG1191	sigma factor activity
DXY21_RS02335	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS02340	COG2208	phosphoserine phosphatase activity
DXY21_RS02345	COG2172	sigma factor antagonist activity
DXY21_RS02350	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS02355	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS02360	COG2337	Toxic component of a toxin-antitoxin (TA) module
DXY21_RS02365	COG0864	Transcriptional regulator
DXY21_RS02370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY21_RS02375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DXY21_RS02385	COG0705	Rhomboid family
DXY21_RS02390	COG3428	Bacterial PH domain
DXY21_RS02395	COG3402	PFAM membrane-flanked domain
DXY21_RS02400	COG0513	Belongs to the DEAD box helicase family
DXY21_RS02405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DXY21_RS02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS02420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY21_RS02435	COG1960	acyl-CoA dehydrogenase activity
DXY21_RS02445	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY21_RS02450	COG1131	(ABC) transporter
DXY21_RS02455	COG0628	permease
DXY21_RS02460	COG1301	dicarboxylic acid transport
DXY21_RS02465	COG4565	transcriptional regulatory protein
DXY21_RS02470	COG3290	protein histidine kinase activity
DXY21_RS02475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DXY21_RS02480	COG3546	catalase activity
DXY21_RS02485	COG2329	Antibiotic biosynthesis monooxygenase
DXY21_RS02490	COG0662	Cupin 2, conserved barrel domain protein
DXY21_RS02495	COG3729	General stress protein
DXY21_RS02500	COG2217	Heavy metal translocating P-type atpase
DXY21_RS02505	COG2076	Multidrug Resistance protein
DXY21_RS02515	COG4876	unkown
DXY21_RS02525	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY21_RS02550	COG0457	Tetratricopeptide repeat
DXY21_RS02600	COG0028	Belongs to the TPP enzyme family
DXY21_RS02605	COG0494	nUDIX hydrolase
DXY21_RS02610	COG0531	amino acid
DXY21_RS02620	COG1215	transferase activity, transferring glycosyl groups
DXY21_RS02625	COG5298	Protein conserved in bacteria
DXY21_RS02630	COG3706	GGDEF domain
DXY21_RS02635	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DXY21_RS02640	COG0551	DNA topoisomerase type I activity
DXY21_RS02640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY21_RS02645	COG1522	sequence-specific DNA binding
DXY21_RS02650	COG2814	Major facilitator Superfamily
DXY21_RS02660	COG3871	stress protein (general stress protein 26)
DXY21_RS02665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY21_RS02670	COG1917	Cupin 2, conserved barrel domain protein
DXY21_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS02680	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS02685	COG3711	transcriptional antiterminator
DXY21_RS02690	COG4989	oxidoreductase activity
DXY21_RS02695	COG0768	penicillin binding
DXY21_RS02700	COG2329	Antibiotic biosynthesis monooxygenase
DXY21_RS02710	COG2755	lipolytic protein G-D-S-L family
DXY21_RS02715	COG1414	Transcriptional regulator
DXY21_RS02720	COG1984	allophanate hydrolase subunit 2
DXY21_RS02725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DXY21_RS02735	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY21_RS02745	COG0561	phosphatase activity
DXY21_RS02755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DXY21_RS02765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS02770	COG2213	PTS system mannitol-specific
DXY21_RS02780	COG1349	DNA-binding transcription factor activity
DXY21_RS02785	COG1276	copper resistance
DXY21_RS02785	COG2372	response to copper ion
DXY21_RS02790	COG4549	nuclear export factor GLE1
DXY21_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS02800	COG4975	Glucose uptake
DXY21_RS02805	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS02810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY21_RS02820	COG0640	Transcriptional regulator
DXY21_RS02825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY21_RS02830	COG0778	Nitroreductase
DXY21_RS02835	COG1309	transcriptional regulator
DXY21_RS02840	COG2814	Major facilitator Superfamily
DXY21_RS02845	COG4607	ABC-type enterochelin transport system periplasmic component
DXY21_RS02850	COG4604	ABC transporter, ATP-binding protein
DXY21_RS02855	COG4605	iron ion homeostasis
DXY21_RS02860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS02865	COG0527	aspartate kinase activity
DXY21_RS02880	COG0457	Tetratricopeptide repeat
DXY21_RS02885	COG3850	Histidine kinase
DXY21_RS02885	COG5002	protein histidine kinase activity
DXY21_RS02890	COG0745	RESPONSE REGULATOR receiver
DXY21_RS02895	COG0577	efflux transmembrane transporter activity
DXY21_RS02900	COG1136	(ABC) transporter
DXY21_RS02905	COG2079	MmgE PrpD family protein
DXY21_RS02915	COG1126	abc transporter atp-binding protein
DXY21_RS02920	COG0765	amino acid transport
DXY21_RS02925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS02940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY21_RS02950	COG0697	spore germination
DXY21_RS02960	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS02965	COG3104	oligopeptide transport
DXY21_RS02980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DXY21_RS02985	COG0163	prenyltransferase activity
DXY21_RS02990	COG0583	DNA-binding transcription factor activity
DXY21_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS03000	COG0765	amino acid transport
DXY21_RS03005	COG1126	abc transporter atp-binding protein
DXY21_RS03010	COG2364	Membrane
DXY21_RS03025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DXY21_RS03030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS03035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS03040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS03045	COG1733	regulation of RNA biosynthetic process
DXY21_RS03050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DXY21_RS03055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DXY21_RS03060	COG3209	COG3209 Rhs family protein
DXY21_RS03075	COG2723	6-phospho-beta-galactosidase activity
DXY21_RS03085	COG1714	RDD family
DXY21_RS03090	COG1063	alcohol dehydrogenase
DXY21_RS03095	COG0523	cobalamin synthesis protein
DXY21_RS03100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY21_RS03105	COG2146	nitrite reductase [NAD(P)H] activity
DXY21_RS03110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY21_RS03110	COG1587	Uroporphyrinogen-III synthase
DXY21_RS03120	COG2508	Transcriptional regulator
DXY21_RS03125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY21_RS03130	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS03135	COG0506	proline dehydrogenase activity
DXY21_RS03140	COG3541	Predicted nucleotidyltransferase
DXY21_RS03145	COG3458	cephalosporin-C deacetylase activity
DXY21_RS03150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DXY21_RS03155	COG2271	Major facilitator Superfamily
DXY21_RS03165	COG1660	Displays ATPase and GTPase activities
DXY21_RS03180	COG3665	Urea carboxylase-associated protein
DXY21_RS03185	COG1113	amino acid transport
DXY21_RS03190	COG3403	YqcI/YcgG family
DXY21_RS03195	COG1280	lysine exporter protein (LysE YggA)
DXY21_RS03200	COG1846	Transcriptional regulator
DXY21_RS03205	COG2814	Major facilitator Superfamily
DXY21_RS03215	COG0366	Alpha amylase catalytic
DXY21_RS03225	COG1288	antiporter activity
DXY21_RS03230	COG1473	amidohydrolase
DXY21_RS03235	COG2113	Glycine betaine
DXY21_RS03240	COG4176	ABC-type proline glycine betaine transport system permease component
DXY21_RS03245	COG0517	IMP dehydrogenase activity
DXY21_RS03245	COG4175	Glycine betaine
DXY21_RS03250	COG0477	Major facilitator Superfamily
DXY21_RS03255	COG3853	Toxic anion resistance protein (TelA)
DXY21_RS03265	COG0861	Integral membrane protein TerC family
DXY21_RS03270	COG2310	stress, protein
DXY21_RS03275	COG2310	stress, protein
DXY21_RS03280	COG2310	stress, protein
DXY21_RS03285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY21_RS03290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY21_RS03295	COG1121	(ABC) transporter
DXY21_RS03300	COG0803	Belongs to the bacterial solute-binding protein 9 family
DXY21_RS03305	COG0366	Alpha amylase catalytic
DXY21_RS03310	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS03315	COG0457	Tetratricopeptide repeat
DXY21_RS03320	COG1876	peptidase activity
DXY21_RS03325	COG1595	DNA-templated transcription, initiation
DXY21_RS03330	COG1595	DNA-templated transcription, initiation
DXY21_RS03340	COG0667	Aldo Keto reductase
DXY21_RS03345	COG3012	SEC-C Motif Domain Protein
DXY21_RS03345	COG1405	negative regulation of cell septum assembly
DXY21_RS03350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DXY21_RS03355	COG0252	asparaginase activity
DXY21_RS03360	COG1309	transcriptional regulator
DXY21_RS03365	COG0477	Major facilitator Superfamily
DXY21_RS03370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY21_RS03380	COG0805	protein transport
DXY21_RS03385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY21_RS03390	COG3540	Alkaline phosphatase
DXY21_RS03395	COG3773	Cell wall hydrolase
DXY21_RS03405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS03410	COG2259	Doxx family
DXY21_RS03415	COG0346	lactoylglutathione lyase activity
DXY21_RS03420	COG0778	Nitroreductase
DXY21_RS03425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY21_RS03435	COG3173	Aminoglycoside phosphotransferase
DXY21_RS03440	COG0784	Response regulator, receiver
DXY21_RS03445	COG4191	Histidine kinase
DXY21_RS03450	COG2066	Belongs to the glutaminase family
DXY21_RS03455	COG1115	amino acid carrier protein
DXY21_RS03460	COG2040	homocysteine
DXY21_RS03465	COG0833	amino acid
DXY21_RS03470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS03475	COG1301	dicarboxylic acid transport
DXY21_RS03490	COG0688	phosphatidylethanolamine metabolic process
DXY21_RS03495	COG0586	Pfam SNARE associated Golgi protein
DXY21_RS03500	COG1183	phosphatidylcholine synthase activity
DXY21_RS03510	COG0371	Dehydrogenase
DXY21_RS03525	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS03535	COG2368	4-hydroxyphenylacetate
DXY21_RS03545	COG2271	Major facilitator Superfamily
DXY21_RS03550	COG0584	glycerophosphoryl diester phosphodiesterase
DXY21_RS03555	COG0531	amino acid
DXY21_RS03595	COG1131	(ABC) transporter
DXY21_RS03600	COG2197	response regulator
DXY21_RS03605	COG4585	Histidine kinase
DXY21_RS03610	COG1011	Hydrolase
DXY21_RS03615	COG1113	amino acid transport
DXY21_RS03620	COG1846	Transcriptional regulator
DXY21_RS03625	COG1380	Effector of murein hydrolase LrgA
DXY21_RS03630	COG1346	cytolysis
DXY21_RS03670	COG4856	YbbR-like protein
DXY21_RS03675	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY21_RS03680	COG5662	AntiSigma factor
DXY21_RS03685	COG1595	DNA-templated transcription, initiation
DXY21_RS03715	COG1683	Conserved Protein
DXY21_RS03720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY21_RS03730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS03730	COG1263	PTS System
DXY21_RS03735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY21_RS03740	COG1472	Belongs to the glycosyl hydrolase 3 family
DXY21_RS03745	COG3876	Protein conserved in bacteria
DXY21_RS03750	COG2207	Transcriptional regulator
DXY21_RS03750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY21_RS03755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY21_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS03765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS03770	COG2819	hydrolase of the alpha beta superfamily
DXY21_RS03775	COG0385	Bile acid
DXY21_RS03780	COG0659	secondary active sulfate transmembrane transporter activity
DXY21_RS03795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS03800	COG0738	Major facilitator superfamily
DXY21_RS03860	COG0726	polysaccharide deacetylase
DXY21_RS03865	COG2194	sulfuric ester hydrolase activity
DXY21_RS03875	COG0489	protein tyrosine kinase activity
DXY21_RS03880	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS03890	COG2318	DinB family
DXY21_RS03895	COG2226	methyltransferase
DXY21_RS03915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY21_RS03920	COG1122	ATPase activity
DXY21_RS03925	COG1122	ATPase activity
DXY21_RS03950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DXY21_RS03955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DXY21_RS03965	COG0024	Methionine aminopeptidase
DXY21_RS03975	COG0201	protein transport
DXY21_RS03985	COG1841	ribosomal large subunit assembly
DXY21_RS04025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DXY21_RS04035	COG0255	Belongs to the universal ribosomal protein uL29 family
DXY21_RS04040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DXY21_RS04045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DXY21_RS04050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DXY21_RS04055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DXY21_RS04065	COG0089	rRNA binding
DXY21_RS04080	COG0051	transcription antitermination factor activity, RNA binding
DXY21_RS04085	COG0596	Alpha beta hydrolase
DXY21_RS04110	COG1358	cellular component organization or biogenesis
DXY21_RS04125	COG2813	Specifically methylates the guanine in position
DXY21_RS04130	COG0222	ribosome binding
DXY21_RS04145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DXY21_RS04150	COG0250	Participates in transcription elongation, termination and antitermination
DXY21_RS04155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY21_RS04160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DXY21_RS04165	COG1595	DNA-templated transcription, initiation
DXY21_RS04170	COG3688	RNA-binding protein containing a PIN domain
DXY21_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY21_RS04180	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DXY21_RS04190	COG1045	serine acetyltransferase
DXY21_RS04210	COG4956	integral membrane protein (PIN domain superfamily)
DXY21_RS04215	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DXY21_RS04220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DXY21_RS04225	COG0542	response to heat
DXY21_RS04235	COG3880	PFAM UvrB UvrC protein
DXY21_RS04240	COG4463	regulation of RNA biosynthetic process
DXY21_RS04320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DXY21_RS04325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY21_RS04330	COG1396	sequence-specific DNA binding
DXY21_RS04335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DXY21_RS04340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DXY21_RS04345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DXY21_RS04350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS04355	COG0512	Glutamine amidotransferase of anthranilate synthase
DXY21_RS04360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY21_RS04365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY21_RS04370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY21_RS04385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DXY21_RS04395	COG0037	tRNA processing
DXY21_RS04400	COG0515	serine threonine protein kinase
DXY21_RS04405	COG2304	oxidoreductase activity
DXY21_RS04410	COG2208	phosphoserine phosphatase activity
DXY21_RS04425	COG1098	S1 RNA binding domain
DXY21_RS04430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DXY21_RS04445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DXY21_RS04450	COG3956	TIGRFAM MazG family protein
DXY21_RS04455	COG2244	polysaccharide biosynthetic process
DXY21_RS04460	COG2002	toxin-antitoxin pair type II binding
DXY21_RS04465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DXY21_RS04485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DXY21_RS04500	COG0251	oxidation-reduction process
DXY21_RS04505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY21_RS04520	COG4466	Protein conserved in bacteria
DXY21_RS04530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DXY21_RS04535	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY21_RS04540	COG3583	domain protein
DXY21_RS04540	COG3584	3D domain protein
DXY21_RS04545	COG0084	hydrolase, TatD family'
DXY21_RS04550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY21_RS04550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY21_RS04555	COG2002	toxin-antitoxin pair type II binding
DXY21_RS04560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DXY21_RS04570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DXY21_RS04580	COG1774	PSP1 C-terminal conserved region
DXY21_RS04585	COG0470	DNA polymerase III
DXY21_RS04590	COG1728	Protein conserved in bacteria
DXY21_RS04595	COG3870	Protein conserved in bacteria
DXY21_RS04605	COG1982	Orn Lys Arg decarboxylase major
DXY21_RS04610	COG3853	Toxic anion resistance protein (TelA)
DXY21_RS04615	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DXY21_RS04665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DXY21_RS04670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DXY21_RS04680	COG0590	tRNA wobble adenosine to inosine editing
DXY21_RS04685	COG1335	isochorismatase
DXY21_RS04690	COG1388	LysM domain
DXY21_RS04690	COG3858	chitin binding
DXY21_RS04695	COG1428	Deoxynucleoside kinase
DXY21_RS04700	COG1428	Deoxynucleoside kinase
DXY21_RS04710	COG1929	Belongs to the glycerate kinase type-1 family
DXY21_RS04730	COG1686	Belongs to the peptidase S11 family
DXY21_RS04735	COG0517	IMP dehydrogenase activity
DXY21_RS04735	COG0516	GMP reductase activity
DXY21_RS04770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY21_RS04775	COG0187	DNA topoisomerase II activity
DXY21_RS04790	COG2501	S4 domain
DXY21_RS04795	COG0592	DNA-directed DNA polymerase activity
DXY21_RS04805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DXY21_RS04815	COG0706	membrane insertase activity
DXY21_RS04820	COG1847	R3H domain protein
DXY21_RS04845	COG1192	Involved in chromosome partitioning
DXY21_RS04850	COG1475	DNA binding
DXY21_RS04865	COG3949	Membrane
DXY21_RS04870	COG4481	Protein conserved in bacteria
DXY21_RS04875	COG0243	molybdopterin cofactor binding
DXY21_RS04880	COG0012	GTP binding
DXY21_RS04890	COG0629	single-stranded DNA binding
DXY21_RS04900	COG2169	Transcriptional regulator
DXY21_RS04905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY21_RS04910	COG0708	Exodeoxyribonuclease III
DXY21_RS04915	COG1609	Transcriptional regulator
DXY21_RS04920	COG0346	lactoylglutathione lyase activity
DXY21_RS04925	COG0477	Major facilitator Superfamily
DXY21_RS04925	COG2814	Major facilitator Superfamily
DXY21_RS04930	COG1266	CAAX protease self-immunity
DXY21_RS04935	COG1331	Highly conserved protein containing a thioredoxin domain
DXY21_RS04940	COG1331	Highly conserved protein containing a thioredoxin domain
DXY21_RS04945	COG1811	Na channel or pump
DXY21_RS04955	COG1331	Highly conserved protein containing a thioredoxin domain
DXY21_RS04960	COG0697	spore germination
DXY21_RS04965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY21_RS04970	COG2153	protein acetylation
DXY21_RS04975	COG1846	Transcriptional regulator
DXY21_RS04980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS04985	COG1846	Transcriptional regulator
DXY21_RS04990	COG0778	Nitroreductase
DXY21_RS05000	COG2211	Major facilitator Superfamily
DXY21_RS05005	COG2318	DinB family
DXY21_RS05010	COG1802	Transcriptional regulator
DXY21_RS05015	COG1621	beta-fructofuranosidase activity
DXY21_RS05020	COG1621	beta-fructofuranosidase activity
DXY21_RS05025	COG0697	spore germination
DXY21_RS05035	COG1733	regulation of RNA biosynthetic process
DXY21_RS05040	COG5577	PFAM Coat F domain
DXY21_RS05050	COG4241	membrane
DXY21_RS05055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DXY21_RS05065	COG0515	serine threonine protein kinase
DXY21_RS05075	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS05080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DXY21_RS05090	COG0297	glycogen (starch) synthase activity
DXY21_RS05095	COG3093	addiction module antidote protein HigA
DXY21_RS05110	COG0305	Participates in initiation and elongation during chromosome replication
DXY21_RS05115	COG0346	lactoylglutathione lyase activity
DXY21_RS05145	COG0745	RESPONSE REGULATOR receiver
DXY21_RS05150	COG5002	protein histidine kinase activity
DXY21_RS05155	COG4863	YycH protein
DXY21_RS05160	COG4853	Protein conserved in bacteria
DXY21_RS05165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DXY21_RS05170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY21_RS05180	COG5002	protein histidine kinase activity
DXY21_RS05185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY21_RS05200	COG0488	(ABC) transporter
DXY21_RS05210	COG3829	transcription factor binding
DXY21_RS05215	COG0640	Transcriptional regulator
DXY21_RS05220	COG5658	integral membrane protein
DXY21_RS05225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY21_RS05230	COG0833	amino acid
DXY21_RS05235	COG0010	Belongs to the arginase family
DXY21_RS05240	COG0457	Tetratricopeptide repeat
DXY21_RS05245	COG0456	acetyltransferase
DXY21_RS05250	COG0667	Aldo Keto reductase
DXY21_RS05255	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DXY21_RS05295	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DXY21_RS05305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DXY21_RS05310	COG2068	MobA-Related Protein
DXY21_RS05325	COG2080	2 iron, 2 sulfur cluster binding
DXY21_RS05335	COG1113	amino acid transport
DXY21_RS05340	COG3634	alkyl hydroperoxide reductase activity
DXY21_RS05345	COG0450	alkyl hydroperoxide reductase
DXY21_RS05360	COG2814	Major facilitator Superfamily
DXY21_RS05365	COG0640	Transcriptional regulator
DXY21_RS05375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DXY21_RS05380	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS05385	COG1309	transcriptional regulator
DXY21_RS05390	COG3239	Fatty acid desaturase
DXY21_RS05395	COG4585	Histidine kinase
DXY21_RS05400	COG2197	response regulator
DXY21_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS05420	COG2814	Major facilitator Superfamily
DXY21_RS05425	COG0667	Aldo Keto reductase
DXY21_RS05430	COG1349	DNA-binding transcription factor activity
DXY21_RS05460	COG2814	Major facilitator Superfamily
DXY21_RS05470	COG1082	Xylose isomerase domain protein TIM barrel
DXY21_RS05485	COG0745	RESPONSE REGULATOR receiver
DXY21_RS05490	COG2205	protein histidine kinase activity
DXY21_RS05495	COG1136	(ABC) transporter
DXY21_RS05500	COG0577	efflux transmembrane transporter activity
DXY21_RS05505	COG5294	Protein conserved in bacteria
DXY21_RS05510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY21_RS05540	COG0561	phosphatase activity
DXY21_RS05545	COG2390	Transcriptional regulator
DXY21_RS05555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY21_RS05560	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DXY21_RS05565	COG0833	amino acid
DXY21_RS05570	COG0010	Belongs to the arginase family
DXY21_RS05595	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY21_RS05600	COG0494	nUDIX hydrolase
DXY21_RS05610	COG0589	response to stress
DXY21_RS05615	COG0697	spore germination
DXY21_RS05680	COG0513	Belongs to the DEAD box helicase family
DXY21_RS05685	COG2270	Major facilitator Superfamily
DXY21_RS05695	COG2273	Hydrolase Family 16
DXY21_RS05700	COG2851	Citrate transporter
DXY21_RS05705	COG0753	catalase activity
DXY21_RS05705	COG0693	protein deglycase activity
DXY21_RS05720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY21_RS05725	COG0500	methyltransferase
DXY21_RS05730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY21_RS05735	COG4894	glucomannan catabolic process
DXY21_RS05745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DXY21_RS05755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS05760	COG2508	Transcriptional regulator
DXY21_RS05765	COG3842	ATPase activity
DXY21_RS05770	COG0726	polysaccharide deacetylase
DXY21_RS05775	COG3493	citrate carrier protein
DXY21_RS05780	COG1271	oxidase subunit
DXY21_RS05785	COG1294	oxidase, subunit
DXY21_RS05790	COG4988	ABC transporter
DXY21_RS05795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DXY21_RS05800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DXY21_RS05805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY21_RS05810	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DXY21_RS05815	COG0753	catalase activity
DXY21_RS05825	COG1482	cell wall glycoprotein biosynthetic process
DXY21_RS05830	COG1940	carbohydrate kinase activity
DXY21_RS05835	COG2723	6-phospho-beta-galactosidase activity
DXY21_RS05840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS05845	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY21_RS05850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS05855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY21_RS05860	COG0640	Transcriptional regulator
DXY21_RS05870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS05875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS05885	COG3711	transcriptional antiterminator
DXY21_RS05885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS05890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS05895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS05900	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY21_RS05905	COG1486	melibiose metabolic process
DXY21_RS05910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS05915	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DXY21_RS05925	COG1696	Membrane protein involved in D-alanine export
DXY21_RS05940	COG1575	Belongs to the MenA family. Type 1 subfamily
DXY21_RS05945	COG2357	RelA SpoT domain protein
DXY21_RS05950	COG1442	glycosyl transferase family 8
DXY21_RS05955	COG1404	Belongs to the peptidase S8 family
DXY21_RS05960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS05965	COG0346	lactoylglutathione lyase activity
DXY21_RS05970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DXY21_RS05975	COG0789	Transcriptional regulator
DXY21_RS05980	COG4895	conserved protein (DUF2196)
DXY21_RS05985	COG1346	cytolysis
DXY21_RS05995	COG0583	DNA-binding transcription factor activity
DXY21_RS06020	COG2837	iron assimilation
DXY21_RS06025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DXY21_RS06045	COG1309	transcriptional regulator
DXY21_RS06050	COG2246	polysaccharide biosynthetic process
DXY21_RS06060	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DXY21_RS06065	COG2261	transglycosylase associated protein
DXY21_RS06070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY21_RS06075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY21_RS06095	COG0454	-acetyltransferase
DXY21_RS06100	COG0772	Belongs to the SEDS family
DXY21_RS06105	COG0778	Nitroreductase
DXY21_RS06110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY21_RS06115	COG1404	Belongs to the peptidase S8 family
DXY21_RS06125	COG3711	transcriptional antiterminator
DXY21_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS06130	COG1263	PTS System
DXY21_RS06135	COG1621	beta-fructofuranosidase activity
DXY21_RS06145	COG0351	phosphomethylpyrimidine kinase
DXY21_RS06150	COG1695	Transcriptional regulator
DXY21_RS06165	COG1216	Glycosyl transferase, family 2
DXY21_RS06180	COG2233	PERMEase
DXY21_RS06185	COG2363	Small membrane protein
DXY21_RS06195	COG0463	Glycosyl transferase, family 2
DXY21_RS06200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY21_RS06205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY21_RS06210	COG0456	acetyltransferase
DXY21_RS06215	COG2089	acid synthase
DXY21_RS06220	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DXY21_RS06225	COG3980	spore coat polysaccharide biosynthesis protein
DXY21_RS06230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DXY21_RS06235	COG1088	dTDP-glucose 4,6-dehydratase activity
DXY21_RS06240	COG1091	dTDP-4-dehydrorhamnose reductase activity
DXY21_RS06245	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DXY21_RS06255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY21_RS06260	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS06265	COG4187	Peptidase family M20/M25/M40
DXY21_RS06270	COG0833	amino acid
DXY21_RS06275	COG2814	Major facilitator Superfamily
DXY21_RS06280	COG2814	Major facilitator Superfamily
DXY21_RS06310	COG0436	Aminotransferase
DXY21_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS06325	COG0280	phosphate acetyltransferase
DXY21_RS06335	COG0583	DNA-binding transcription factor activity
DXY21_RS06365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY21_RS06370	COG1131	(ABC) transporter
DXY21_RS06380	COG1695	Transcriptional regulator
DXY21_RS06395	COG1078	dGTPase activity
DXY21_RS06400	COG3465	dGTPase activity
DXY21_RS06405	COG0531	amino acid
DXY21_RS06410	COG1846	Transcriptional regulator
DXY21_RS06415	COG1942	4-Oxalocrotonate Tautomerase
DXY21_RS06420	COG1994	Peptidase M50
DXY21_RS06435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY21_RS06440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DXY21_RS06445	COG0010	Belongs to the arginase family
DXY21_RS06490	COG0457	Tetratricopeptide repeat
DXY21_RS06495	COG4506	Protein conserved in bacteria
DXY21_RS06505	COG2223	nitrite transmembrane transporter activity
DXY21_RS06510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY21_RS06520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY21_RS06525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DXY21_RS06530	COG1140	nitrate reductase beta subunit
DXY21_RS06535	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DXY21_RS06540	COG2181	nitrate reductase activity
DXY21_RS06550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY21_RS06555	COG1132	(ABC) transporter
DXY21_RS06570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY21_RS06575	COG0247	lactate metabolic process
DXY21_RS06575	COG2181	nitrate reductase activity
DXY21_RS06590	COG4821	SIS domain
DXY21_RS06595	COG2204	response regulator
DXY21_RS06600	COG0191	fructose-bisphosphate aldolase activity
DXY21_RS06610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY21_RS06615	COG1494	fructose-1,6-bisphosphatase
DXY21_RS06620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DXY21_RS06625	COG0254	rRNA binding
DXY21_RS06635	COG0281	malic enzyme
DXY21_RS06640	COG0679	Auxin Efflux Carrier
DXY21_RS06645	COG0789	Transcriptional regulator
DXY21_RS06650	COG0346	lactoylglutathione lyase activity
DXY21_RS06655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DXY21_RS06660	COG2890	protein-(glutamine-N5) methyltransferase activity
DXY21_RS06680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DXY21_RS06685	COG0009	L-threonylcarbamoyladenylate synthase
DXY21_RS06695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY21_RS06700	COG0698	ribose 5-phosphate isomerase
DXY21_RS06730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DXY21_RS06770	COG4836	Membrane
DXY21_RS06780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY21_RS06785	COG2385	sporulation resulting in formation of a cellular spore
DXY21_RS06790	COG2304	oxidoreductase activity
DXY21_RS06795	COG2304	oxidoreductase activity
DXY21_RS06800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DXY21_RS06810	COG0457	Tetratricopeptide repeat
DXY21_RS06815	COG1994	Peptidase M50
DXY21_RS06820	COG3237	CsbD-like
DXY21_RS06825	COG0831	urea catabolic process
DXY21_RS06840	COG1959	2 iron, 2 sulfur cluster binding
DXY21_RS06850	COG0726	polysaccharide deacetylase
DXY21_RS06860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY21_RS06875	COG1247	-acetyltransferase
DXY21_RS06880	COG0739	heme binding
DXY21_RS06890	COG0671	phosphoesterase, PA-phosphatase related
DXY21_RS06895	COG0772	Belongs to the SEDS family
DXY21_RS06900	COG0347	Belongs to the P(II) protein family
DXY21_RS06905	COG0004	ammonium transporteR
DXY21_RS06910	COG1335	isochorismatase
DXY21_RS06915	COG0477	Major facilitator Superfamily
DXY21_RS06920	COG1953	Uracil, thiamine, allantoin
DXY21_RS06925	COG2814	Major facilitator Superfamily
DXY21_RS06930	COG1846	Transcriptional regulator
DXY21_RS06935	COG1609	Transcriptional regulator
DXY21_RS06940	COG1077	Cell shape determining protein MreB Mrl
DXY21_RS06945	COG4786	Flagellar basal body rod
DXY21_RS06950	COG4786	Flagellar basal body rod
DXY21_RS06955	COG0457	Tetratricopeptide repeat
DXY21_RS06980	COG0629	single-stranded DNA binding
DXY21_RS06985	COG1349	DNA-binding transcription factor activity
DXY21_RS06990	COG0561	phosphatase activity
DXY21_RS06995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY21_RS07000	COG4715	Zinc finger, swim domain protein
DXY21_RS07010	COG3944	biosynthesis protein
DXY21_RS07015	COG0489	protein tyrosine kinase activity
DXY21_RS07020	COG4464	protein tyrosine phosphatase activity
DXY21_RS07025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY21_RS07030	COG3878	Protein conserved in bacteria
DXY21_RS07075	COG0583	DNA-binding transcription factor activity
DXY21_RS07080	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY21_RS07090	COG2059	Chromate
DXY21_RS07095	COG2059	Chromate
DXY21_RS07100	COG1522	sequence-specific DNA binding
DXY21_RS07105	COG0405	Gamma-glutamyltransferase
DXY21_RS07115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DXY21_RS07125	COG5337	Spore coat protein CotH
DXY21_RS07140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY21_RS07145	COG0583	DNA-binding transcription factor activity
DXY21_RS07150	COG0028	Belongs to the TPP enzyme family
DXY21_RS07155	COG3527	Alpha-acetolactate decarboxylase
DXY21_RS07160	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY21_RS07165	COG3103	Sh3 type 3 domain protein
DXY21_RS07170	COG1879	ABC-type sugar transport system periplasmic component
DXY21_RS07175	COG1172	Belongs to the binding-protein-dependent transport system permease family
DXY21_RS07180	COG1129	ABC transporter
DXY21_RS07190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY21_RS07195	COG1609	Transcriptional regulator
DXY21_RS07205	COG0814	amino acid
DXY21_RS07210	COG0697	spore germination
DXY21_RS07215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DXY21_RS07225	COG2843	Capsule synthesis protein
DXY21_RS07235	COG0791	NLP P60 protein
DXY21_RS07240	COG2433	Pfam Transposase IS66
DXY21_RS07245	COG0561	phosphatase activity
DXY21_RS07250	COG1316	TRANSCRIPTIONal
DXY21_RS07255	COG2814	Major facilitator Superfamily
DXY21_RS07260	COG1215	transferase activity, transferring glycosyl groups
DXY21_RS07270	COG0814	amino acid
DXY21_RS07275	COG0697	spore germination
DXY21_RS07280	COG1482	cell wall glycoprotein biosynthetic process
DXY21_RS07285	COG4193	domain, Protein
DXY21_RS07290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY21_RS07295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DXY21_RS07300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DXY21_RS07310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY21_RS07315	COG1682	transport, permease protein
DXY21_RS07320	COG1134	teichoic acid transport
DXY21_RS07325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY21_RS07330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DXY21_RS07335	COG1316	TRANSCRIPTIONal
DXY21_RS07345	COG2247	cell wall binding repeat
DXY21_RS07345	COG2385	sporulation resulting in formation of a cellular spore
DXY21_RS07350	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS07350	COG2247	cell wall binding repeat
DXY21_RS07360	COG2244	polysaccharide biosynthetic process
DXY21_RS07365	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS07365	COG0297	glycogen (starch) synthase activity
DXY21_RS07370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY21_RS07375	COG3307	-O-antigen
DXY21_RS07380	COG3206	protein involved in exopolysaccharide biosynthesis
DXY21_RS07385	COG1215	transferase activity, transferring glycosyl groups
DXY21_RS07390	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS07395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DXY21_RS07400	COG1316	TRANSCRIPTIONal
DXY21_RS07405	COG1739	Uncharacterized protein family UPF0029
DXY21_RS07410	COG4585	Histidine kinase
DXY21_RS07415	COG2197	response regulator
DXY21_RS07420	COG1307	EDD domain protein, DegV family
DXY21_RS07425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DXY21_RS07435	COG1040	competence protein
DXY21_RS07445	COG2747	anti-sigma28 factor FlgM
DXY21_RS07450	COG3418	PFAM FlgN family protein
DXY21_RS07455	COG1256	bacterial-type flagellum assembly
DXY21_RS07455	COG4786	Flagellar basal body rod
DXY21_RS07460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY21_RS07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY21_RS07485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DXY21_RS07490	COG1516	flagellar protein fliS
DXY21_RS07505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DXY21_RS07520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS07525	COG2010	Cytochrome c
DXY21_RS07530	COG2884	Cell division ATP-binding protein ftsE
DXY21_RS07535	COG2177	Part of the ABC transporter FtsEX involved in
DXY21_RS07540	COG3420	alginic acid biosynthetic process
DXY21_RS07545	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS07545	COG0793	Belongs to the peptidase S41A family
DXY21_RS07555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY21_RS07585	COG2814	Major facilitator Superfamily
DXY21_RS07590	COG1309	transcriptional regulator
DXY21_RS07595	COG0574	Belongs to the PEP-utilizing enzyme family
DXY21_RS07595	COG3848	Pyruvate phosphate dikinase
DXY21_RS07600	COG4897	Protein conserved in bacteria
DXY21_RS07610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DXY21_RS07625	COG3595	metallopeptidase activity
DXY21_RS07630	COG1983	PspC domain protein
DXY21_RS07635	COG1950	PFAM Membrane protein of
DXY21_RS07640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DXY21_RS07645	COG1309	transcriptional regulator
DXY21_RS07660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DXY21_RS07680	COG0110	maltose O-acetyltransferase activity
DXY21_RS07685	COG4990	cell redox homeostasis
DXY21_RS07700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DXY21_RS07725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DXY21_RS07725	COG0140	phosphoribosyl-ATP diphosphatase activity
DXY21_RS07730	COG1132	(ABC) transporter
DXY21_RS07740	COG0745	RESPONSE REGULATOR receiver
DXY21_RS07745	COG5002	protein histidine kinase activity
DXY21_RS07750	COG0457	Tetratricopeptide repeat
DXY21_RS07755	COG3883	PFAM NLP P60 protein
DXY21_RS07755	COG0791	NLP P60 protein
DXY21_RS07760	COG0492	ferredoxin-NADP+ reductase activity
DXY21_RS07765	COG1051	belongs to the nudix hydrolase family
DXY21_RS07775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DXY21_RS07785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS07790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DXY21_RS07795	COG4290	ribonuclease
DXY21_RS07800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY21_RS07805	COG0288	reversible hydration of carbon dioxide
DXY21_RS07810	COG0659	secondary active sulfate transmembrane transporter activity
DXY21_RS07815	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY21_RS07820	COG1611	Belongs to the LOG family
DXY21_RS07825	COG2814	Major facilitator Superfamily
DXY21_RS07825	COG0477	Major facilitator Superfamily
DXY21_RS07830	COG2828	Protein conserved in bacteria
DXY21_RS07835	COG0583	DNA-binding transcription factor activity
DXY21_RS07845	COG1609	Transcriptional regulator
DXY21_RS07850	COG2223	nitrite transmembrane transporter activity
DXY21_RS07895	COG3479	Phenolic acid decarboxylase
DXY21_RS07900	COG0456	acetyltransferase
DXY21_RS07905	COG2364	Membrane
DXY21_RS07910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY21_RS07920	COG2272	Belongs to the type-B carboxylesterase lipase family
DXY21_RS07925	COG1396	sequence-specific DNA binding
DXY21_RS07930	COG3944	biosynthesis protein
DXY21_RS07935	COG0489	protein tyrosine kinase activity
DXY21_RS07940	COG1086	Polysaccharide biosynthesis protein
DXY21_RS07945	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS07950	COG1215	transferase activity, transferring glycosyl groups
DXY21_RS07955	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS07965	COG1216	Glycosyl transferase, family 2
DXY21_RS07970	COG5039	Polysaccharide pyruvyl transferase
DXY21_RS07975	COG1216	Glycosyl transferase, family 2
DXY21_RS07980	COG2244	polysaccharide biosynthetic process
DXY21_RS07985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DXY21_RS07990	COG0110	maltose O-acetyltransferase activity
DXY21_RS07995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY21_RS08000	COG5039	Polysaccharide pyruvyl transferase
DXY21_RS08010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DXY21_RS08015	COG1620	l-lactate permease
DXY21_RS08020	COG2186	Transcriptional regulator
DXY21_RS08025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY21_RS08050	COG1070	Carbohydrate kinase
DXY21_RS08055	COG1737	Transcriptional regulator
DXY21_RS08060	COG1113	amino acid transport
DXY21_RS08065	COG0697	spore germination
DXY21_RS08070	COG0583	DNA-binding transcription factor activity
DXY21_RS08080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY21_RS08085	COG1609	Transcriptional regulator
DXY21_RS08090	COG2814	Major facilitator Superfamily
DXY21_RS08095	COG2390	Transcriptional regulator
DXY21_RS08100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY21_RS08105	COG0126	phosphoglycerate kinase activity
DXY21_RS08125	COG2234	aminopeptidase activity
DXY21_RS08135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY21_RS08140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS08145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY21_RS08160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY21_RS08175	COG0456	acetyltransferase
DXY21_RS08180	COG4640	response to antibiotic
DXY21_RS08185	COG3064	Membrane
DXY21_RS08190	COG2095	MarC family integral membrane protein
DXY21_RS08195	COG1510	regulation of RNA biosynthetic process
DXY21_RS08200	COG1125	glycine betaine transport
DXY21_RS08200	COG0517	IMP dehydrogenase activity
DXY21_RS08205	COG1174	glycine betaine transport
DXY21_RS08210	COG1732	Glycine betaine
DXY21_RS08215	COG1174	glycine betaine transport
DXY21_RS08220	COG1510	regulation of RNA biosynthetic process
DXY21_RS08225	COG1125	glycine betaine transport
DXY21_RS08225	COG0517	IMP dehydrogenase activity
DXY21_RS08230	COG1174	glycine betaine transport
DXY21_RS08235	COG1732	Glycine betaine
DXY21_RS08240	COG1174	glycine betaine transport
DXY21_RS08270	COG1733	regulation of RNA biosynthetic process
DXY21_RS08275	COG1396	sequence-specific DNA binding
DXY21_RS08280	COG1396	sequence-specific DNA binding
DXY21_RS08285	COG1476	TRANSCRIPTIONal
DXY21_RS08290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY21_RS08295	COG1647	Serine aminopeptidase, S33
DXY21_RS08300	COG0557	exoribonuclease II activity
DXY21_RS08315	COG2732	(Barnase) inhibitor
DXY21_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS08325	COG0583	DNA-binding transcription factor activity
DXY21_RS08330	COG0454	-acetyltransferase
DXY21_RS08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS08345	COG0765	amino acid transport
DXY21_RS08350	COG0765	amino acid transport
DXY21_RS08355	COG1126	abc transporter atp-binding protein
DXY21_RS08360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY21_RS08365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DXY21_RS08370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY21_RS08385	COG2814	Major facilitator Superfamily
DXY21_RS08400	COG0673	inositol 2-dehydrogenase activity
DXY21_RS08405	COG1937	Protein conserved in bacteria
DXY21_RS08410	COG2608	mercury ion transmembrane transporter activity
DXY21_RS08415	COG2217	Heavy metal translocating P-type atpase
DXY21_RS08420	COG2217	Heavy metal translocating P-type atpase
DXY21_RS08425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DXY21_RS08430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DXY21_RS08440	COG2860	membrane
DXY21_RS08445	COG3973	AAA domain
DXY21_RS08450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY21_RS08470	COG0656	L-ascorbic acid biosynthetic process
DXY21_RS08475	COG0842	Transport permease protein
DXY21_RS08485	COG1131	(ABC) transporter
DXY21_RS08490	COG3850	Histidine kinase
DXY21_RS08495	COG2197	response regulator
DXY21_RS08500	COG4149	molybdate abc transporter
DXY21_RS08505	COG0725	ABC transporter, periplasmic molybdate-binding protein
DXY21_RS08515	COG1368	sulfuric ester hydrolase activity
DXY21_RS08520	COG1988	membrane-bound metal-dependent
DXY21_RS08530	COG0531	amino acid
DXY21_RS08535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DXY21_RS08540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY21_RS08545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS08550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS08555	COG1120	ATPase activity
DXY21_RS08565	COG2140	Oxalate decarboxylase
DXY21_RS08575	COG1191	sigma factor activity
DXY21_RS08585	COG0745	RESPONSE REGULATOR receiver
DXY21_RS08590	COG2205	protein histidine kinase activity
DXY21_RS08595	COG3386	PFAM SMP-30 Gluconolaconase
DXY21_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS08605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY21_RS08610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY21_RS08615	COG1120	ATPase activity
DXY21_RS08620	COG2096	Adenosyltransferase
DXY21_RS08625	COG2814	Major facilitator Superfamily
DXY21_RS08630	COG4758	membrane
DXY21_RS08635	COG1842	Phage shock protein A
DXY21_RS08640	COG3595	metallopeptidase activity
DXY21_RS08645	COG4758	membrane
DXY21_RS08650	COG4585	Histidine kinase
DXY21_RS08655	COG2197	response regulator
DXY21_RS08665	COG0814	amino acid
DXY21_RS08670	COG0697	spore germination
DXY21_RS08680	COG0114	fumarate hydratase activity
DXY21_RS08685	COG1309	transcriptional regulator
DXY21_RS08695	COG2770	Histidine kinase
DXY21_RS08695	COG2205	protein histidine kinase activity
DXY21_RS08700	COG0745	RESPONSE REGULATOR receiver
DXY21_RS08705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY21_RS08710	COG0783	Belongs to the Dps family
DXY21_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS08730	COG1120	ATPase activity
DXY21_RS08750	COG0583	DNA-binding transcription factor activity
DXY21_RS08755	COG0477	Major facilitator Superfamily
DXY21_RS08760	COG1846	Transcriptional regulator
DXY21_RS08765	COG5577	PFAM Coat F domain
DXY21_RS08785	COG1024	Enoyl-CoA hydratase
DXY21_RS08785	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY21_RS08790	COG0183	Belongs to the thiolase family
DXY21_RS08795	COG1960	acyl-CoA dehydrogenase activity
DXY21_RS08800	COG1393	Belongs to the ArsC family
DXY21_RS08815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY21_RS08820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS08830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DXY21_RS08835	COG2011	ABC-type metal ion transport system permease component
DXY21_RS08840	COG1464	Belongs to the NlpA lipoprotein family
DXY21_RS08845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DXY21_RS08855	COG0396	ATPase activity
DXY21_RS08860	COG0719	Fe-S assembly protein
DXY21_RS08865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY21_RS08870	COG0822	iron-sulfur transferase activity
DXY21_RS08875	COG0719	Fe-S assembly protein
DXY21_RS08880	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS08890	COG2226	methyltransferase
DXY21_RS08895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY21_RS08900	COG0322	excinuclease ABC activity
DXY21_RS08910	COG2222	sugar isomerase
DXY21_RS08915	COG1653	transport
DXY21_RS08920	COG1175	transmembrane transport
DXY21_RS08925	COG0395	ABC-type sugar transport system, permease component
DXY21_RS08930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY21_RS08935	COG2188	Transcriptional regulator
DXY21_RS08940	COG3842	ATPase activity
DXY21_RS08945	COG2356	endonuclease I
DXY21_RS08950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY21_RS08955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DXY21_RS08960	COG2814	Major facilitator Superfamily
DXY21_RS08980	COG2508	Transcriptional regulator
DXY21_RS08995	COG1801	Protein of unknown function DUF72
DXY21_RS09000	COG0730	response to heat
DXY21_RS09005	COG0737	Belongs to the 5'-nucleotidase family
DXY21_RS09015	COG0739	heme binding
DXY21_RS09025	COG4470	Protein conserved in bacteria
DXY21_RS09030	COG2445	Protein of unknown function DUF86
DXY21_RS09035	COG0647	UMP catabolic process
DXY21_RS09040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DXY21_RS09045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY21_RS09050	COG0460	homoserine dehydrogenase
DXY21_RS09055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DXY21_RS09065	COG4946	Tricorn protease homolog
DXY21_RS09065	COG0823	Involved in the tonB-independent uptake of proteins
DXY21_RS09065	COG1506	peptidase
DXY21_RS09070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DXY21_RS09075	COG4837	Protein of unknown function (DUF1462)
DXY21_RS09080	COG1252	NADH dehydrogenase
DXY21_RS09090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY21_RS09100	COG0316	Belongs to the HesB IscA family
DXY21_RS09105	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DXY21_RS09130	COG1131	(ABC) transporter
DXY21_RS09155	COG1252	NADH dehydrogenase
DXY21_RS09170	COG3584	3D domain protein
DXY21_RS09175	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DXY21_RS09185	COG2056	Na+-H+ antiporter family
DXY21_RS09190	COG1268	BioY protein
DXY21_RS09195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY21_RS09200	COG2819	hydrolase of the alpha beta superfamily
DXY21_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS09210	COG1169	isochorismate synthase
DXY21_RS09215	COG1021	2,3-dihydroxybenzoate-AMP ligase
DXY21_RS09220	COG1535	isochorismatase
DXY21_RS09220	COG3433	isochorismatase activity
DXY21_RS09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS09230	COG3251	PFAM MbtH domain protein
DXY21_RS09235	COG5634	Uncharacterized conserved protein (DUF2278)
DXY21_RS09240	COG0686	Belongs to the AlaDH PNT family
DXY21_RS09245	COG2508	Transcriptional regulator
DXY21_RS09245	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DXY21_RS09250	COG4842	Belongs to the WXG100 family
DXY21_RS09255	COG5417	Belongs to the EsaB family
DXY21_RS09260	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY21_RS09265	COG0433	COG0433 Predicted ATPase
DXY21_RS09265	COG1674	ftsk spoiiie
DXY21_RS09270	COG1511	domain protein
DXY21_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS09285	COG1418	mRNA catabolic process
DXY21_RS09295	COG0628	permease
DXY21_RS09310	COG5506	Protein of unknown function (DUF1694)
DXY21_RS09315	COG1335	isochorismatase
DXY21_RS09320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DXY21_RS09325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DXY21_RS09340	COG0142	geranyltranstransferase activity
DXY21_RS09350	COG4585	Histidine kinase
DXY21_RS09355	COG2197	response regulator
DXY21_RS09360	COG2050	protein possibly involved in aromatic compounds catabolism
DXY21_RS09365	COG1320	monovalent cation:proton antiporter activity
DXY21_RS09370	COG2212	antiporter activity
DXY21_RS09375	COG1863	multisubunit Na H antiporter MnhE subunit
DXY21_RS09380	COG0651	ATP synthesis coupled electron transport
DXY21_RS09385	COG1006	Multisubunit Na H antiporter MnhC subunit
DXY21_RS09390	COG2111	Na H antiporter
DXY21_RS09395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DXY21_RS09395	COG2111	Na H antiporter
DXY21_RS09425	COG4565	transcriptional regulatory protein
DXY21_RS09430	COG3290	protein histidine kinase activity
DXY21_RS09440	COG3011	Protein conserved in bacteria
DXY21_RS09445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY21_RS09450	COG2814	Major facilitator Superfamily
DXY21_RS09455	COG5018	Exonuclease
DXY21_RS09465	COG2205	protein histidine kinase activity
DXY21_RS09470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DXY21_RS09480	COG2267	carboxylic ester hydrolase activity
DXY21_RS09485	COG1522	sequence-specific DNA binding
DXY21_RS09490	COG0436	Aminotransferase
DXY21_RS09495	COG1098	S1 RNA binding domain
DXY21_RS09500	COG2155	Conserved Protein
DXY21_RS09505	COG1979	alcohol dehydrogenase
DXY21_RS09510	COG1979	alcohol dehydrogenase
DXY21_RS09515	COG1335	isochorismatase
DXY21_RS09540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DXY21_RS09555	COG2738	Putative neutral zinc metallopeptidase
DXY21_RS09560	COG1253	flavin adenine dinucleotide binding
DXY21_RS09565	COG0366	Alpha amylase catalytic
DXY21_RS09570	COG0432	Pfam Uncharacterised protein family UPF0047
DXY21_RS09575	COG2070	2-Nitropropane dioxygenase
DXY21_RS09590	COG0840	transmembrane signaling receptor activity
DXY21_RS09595	COG0840	transmembrane signaling receptor activity
DXY21_RS09600	COG0840	transmembrane signaling receptor activity
DXY21_RS09605	COG0840	transmembrane signaling receptor activity
DXY21_RS09610	COG0693	protein deglycase activity
DXY21_RS09615	COG0673	inositol 2-dehydrogenase activity
DXY21_RS09620	COG0628	permease
DXY21_RS09645	COG1017	nitric oxide dioxygenase activity
DXY21_RS09645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DXY21_RS09650	COG1705	Flagellar rod assembly protein muramidase FlgJ
DXY21_RS09655	COG0569	domain protein
DXY21_RS09665	COG1510	regulation of RNA biosynthetic process
DXY21_RS09675	COG1454	alcohol dehydrogenase
DXY21_RS09685	COG2318	DinB family
DXY21_RS09690	COG1585	Membrane protein implicated in regulation of membrane protease activity
DXY21_RS09695	COG2268	Band 7 protein
DXY21_RS09700	COG3859	Proton-coupled thiamine transporter YuaJ
DXY21_RS09825	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DXY21_RS09830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY21_RS09835	COG1169	isochorismate synthase
DXY21_RS09845	COG0596	Alpha beta hydrolase
DXY21_RS09850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DXY21_RS09860	COG4948	Mandelate Racemase Muconate Lactonizing
DXY21_RS09870	COG1294	oxidase, subunit
DXY21_RS09875	COG1271	oxidase subunit
DXY21_RS09885	COG0288	reversible hydration of carbon dioxide
DXY21_RS09910	COG0783	Belongs to the Dps family
DXY21_RS09915	COG4824	toxin secretion phage lysis holin
DXY21_RS09920	COG0494	nUDIX hydrolase
DXY21_RS09925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY21_RS09930	COG1116	anion transmembrane transporter activity
DXY21_RS09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY21_RS09940	COG1506	peptidase
DXY21_RS09960	COG0367	asparagine synthase
DXY21_RS09965	COG1113	amino acid transport
DXY21_RS09970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DXY21_RS09975	COG2267	carboxylic ester hydrolase activity
DXY21_RS09985	COG0584	glycerophosphoryl diester phosphodiesterase
DXY21_RS09995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DXY21_RS10000	COG1242	4 iron, 4 sulfur cluster binding
DXY21_RS10005	COG0477	Major facilitator Superfamily
DXY21_RS10020	COG1725	Transcriptional regulator
DXY21_RS10025	COG1131	(ABC) transporter
DXY21_RS10045	COG1136	(ABC) transporter
DXY21_RS10050	COG0577	efflux transmembrane transporter activity
DXY21_RS10055	COG0745	RESPONSE REGULATOR receiver
DXY21_RS10060	COG2205	protein histidine kinase activity
DXY21_RS10065	COG1136	(ABC) transporter
DXY21_RS10070	COG0577	efflux transmembrane transporter activity
DXY21_RS10075	COG5522	Integral membrane protein (intg_mem_TP0381)
DXY21_RS10080	COG2814	Major facilitator Superfamily
DXY21_RS10085	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS10085	COG2202	Pas domain
DXY21_RS10100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY21_RS10110	COG1486	melibiose metabolic process
DXY21_RS10140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DXY21_RS10145	COG2081	HI0933 family
DXY21_RS10150	COG2244	polysaccharide biosynthetic process
DXY21_RS10155	COG1187	pseudouridine synthase activity
DXY21_RS10160	COG1349	DNA-binding transcription factor activity
DXY21_RS10165	COG1131	(ABC) transporter
DXY21_RS10170	COG4473	ABC transporter
DXY21_RS10175	COG2252	PERMEase
DXY21_RS10180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY21_RS10185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY21_RS10190	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DXY21_RS10200	COG1597	lipid kinase activity
DXY21_RS10205	COG0510	thiamine kinase activity
DXY21_RS10220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS10225	COG0281	malic enzyme
DXY21_RS10230	COG5584	Small secreted protein
DXY21_RS10235	COG1363	Peptidase, m42
DXY21_RS10245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS10255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY21_RS10260	COG1674	ftsk spoiiie
DXY21_RS10270	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY21_RS10275	COG4980	gas vesicle protein
DXY21_RS10280	COG3118	belongs to the thioredoxin family
DXY21_RS10285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DXY21_RS10285	COG1605	Chorismate mutase
DXY21_RS10290	COG1609	Transcriptional regulator
DXY21_RS10295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY21_RS10300	COG1360	Flagellar Motor Protein
DXY21_RS10305	COG0123	including yeast histone deacetylase and acetoin utilization protein
DXY21_RS10310	COG0517	IMP dehydrogenase activity
DXY21_RS10315	COG0454	-acetyltransferase
DXY21_RS10320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY21_RS10340	COG1378	Sugar-specific transcriptional regulator TrmB
DXY21_RS10345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY21_RS10360	COG0693	protein deglycase activity
DXY21_RS10370	COG1017	nitric oxide dioxygenase activity
DXY21_RS10370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DXY21_RS10375	COG4282	regulation of fungal-type cell wall biogenesis
DXY21_RS10380	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS10395	COG2203	Gaf domain
DXY21_RS10395	COG2199	diguanylate cyclase activity
DXY21_RS10400	COG1956	GAF domain-containing protein
DXY21_RS10405	COG1309	transcriptional regulator
DXY21_RS10410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY21_RS10420	COG1114	Component of the transport system for branched-chain amino acids
DXY21_RS10425	COG1104	cysteine desulfurase activity
DXY21_RS10440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY21_RS10445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DXY21_RS10450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY21_RS10455	COG0616	signal peptide processing
DXY21_RS10460	COG1714	RDD family
DXY21_RS10470	COG3874	Sporulation protein YtfJ
DXY21_RS10475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DXY21_RS10480	COG0827	DNA restriction-modification system
DXY21_RS10490	COG0521	Mo-molybdopterin cofactor biosynthetic process
DXY21_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS10515	COG4109	DRTGG domain
DXY21_RS10525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DXY21_RS10545	COG0587	DNA-directed DNA polymerase activity
DXY21_RS10550	COG0281	malic enzyme
DXY21_RS10570	COG0469	pyruvate kinase activity
DXY21_RS10575	COG3030	protein affecting phage T7 exclusion by the F plasmid
DXY21_RS10580	COG0628	permease
DXY21_RS10600	COG0372	Belongs to the citrate synthase family
DXY21_RS10605	COG0538	isocitrate dehydrogenase activity
DXY21_RS10615	COG0745	RESPONSE REGULATOR receiver
DXY21_RS10620	COG5002	protein histidine kinase activity
DXY21_RS10625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY21_RS10625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY21_RS10630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DXY21_RS10635	COG1971	Probably functions as a manganese efflux pump
DXY21_RS10640	COG0237	dephospho-CoA kinase activity
DXY21_RS10645	COG0656	L-ascorbic acid biosynthetic process
DXY21_RS10650	COG2814	Major facilitator Superfamily
DXY21_RS10655	COG1733	regulation of RNA biosynthetic process
DXY21_RS10660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY21_RS10675	COG3611	Membrane attachment protein
DXY21_RS10680	COG1484	DNA-dependent DNA replication
DXY21_RS10685	COG0398	Pfam SNARE associated Golgi protein
DXY21_RS10705	COG3275	phosphorelay sensor kinase activity
DXY21_RS10710	COG3279	Response regulator of the LytR AlgR family
DXY21_RS10715	COG1380	Effector of murein hydrolase LrgA
DXY21_RS10720	COG1346	cytolysis
DXY21_RS10725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DXY21_RS10735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DXY21_RS10740	COG3326	Membrane
DXY21_RS10750	COG1363	Peptidase, m42
DXY21_RS10755	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY21_RS10760	COG2160	L-arabinose isomerase activity
DXY21_RS10765	COG1069	ribulokinase activity
DXY21_RS10770	COG0235	Class ii aldolase
DXY21_RS10775	COG0647	UMP catabolic process
DXY21_RS10790	COG1175	transmembrane transport
DXY21_RS10795	COG0395	ABC-type sugar transport system, permease component
DXY21_RS10800	COG3534	alpha-L-arabinofuranosidase
DXY21_RS10805	COG1966	Carbon starvation protein
DXY21_RS10810	COG0247	lactate metabolic process
DXY21_RS10815	COG0277	FAD linked oxidase domain protein
DXY21_RS10820	COG3835	regulator
DXY21_RS10830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY21_RS10835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DXY21_RS10840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY21_RS10840	COG0072	phenylalanine-tRNA ligase activity
DXY21_RS10855	COG1286	toxin biosynthetic process
DXY21_RS10860	COG1796	DNA polymerase
DXY21_RS10860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY21_RS10870	COG3766	membrane
DXY21_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS10885	COG1309	transcriptional regulator
DXY21_RS10890	COG1024	Enoyl-CoA hydratase
DXY21_RS10895	COG2086	electron transfer activity
DXY21_RS10900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DXY21_RS10905	COG3534	alpha-L-arabinofuranosidase
DXY21_RS10910	COG3118	belongs to the thioredoxin family
DXY21_RS10920	COG0527	aspartate kinase activity
DXY21_RS10925	COG1719	4-vinyl reductase, 4VR
DXY21_RS10930	COG2009	succinate dehydrogenase
DXY21_RS10935	COG1053	succinate dehydrogenase
DXY21_RS10940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DXY21_RS10945	COG0824	Thioesterase
DXY21_RS10950	COG2197	response regulator
DXY21_RS10955	COG1846	Transcriptional regulator
DXY21_RS10965	COG5401	PFAM Sporulation and spore germination
DXY21_RS10975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DXY21_RS10980	COG0622	Phosphoesterase
DXY21_RS11000	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DXY21_RS11030	COG0028	Belongs to the TPP enzyme family
DXY21_RS11035	COG0440	acetolactate synthase activity
DXY21_RS11050	COG0473	3-isopropylmalate dehydrogenase activity
DXY21_RS11065	COG1477	protein flavinylation
DXY21_RS11065	COG0457	Tetratricopeptide repeat
DXY21_RS11080	COG1067	ATP-dependent peptidase activity
DXY21_RS11080	COG0470	DNA polymerase III
DXY21_RS11085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DXY21_RS11105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY21_RS11115	COG1587	Uroporphyrinogen-III synthase
DXY21_RS11120	COG0113	porphobilinogen synthase activity
DXY21_RS11130	COG1388	LysM domain
DXY21_RS11135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY21_RS11145	COG0525	valine-tRNA ligase activity
DXY21_RS11150	COG0285	dihydrofolate synthase activity
DXY21_RS11155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DXY21_RS11175	COG1077	Cell shape determining protein MreB Mrl
DXY21_RS11180	COG1792	Involved in formation and maintenance of cell shape
DXY21_RS11185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DXY21_RS11195	COG2894	cell division
DXY21_RS11200	COG0739	heme binding
DXY21_RS11205	COG1994	Peptidase M50
DXY21_RS11215	COG2868	ribosomal protein
DXY21_RS11220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DXY21_RS11225	COG3290	protein histidine kinase activity
DXY21_RS11240	COG0077	Prephenate dehydratase
DXY21_RS11245	COG1827	regulation of RNA biosynthetic process
DXY21_RS11250	COG1104	cysteine desulfurase activity
DXY21_RS11255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DXY21_RS11260	COG0157	Belongs to the NadC ModD family
DXY21_RS11270	COG1388	LysM domain
DXY21_RS11315	COG1862	Preprotein translocase
DXY21_RS11325	COG2323	membrane
DXY21_RS11330	COG2244	polysaccharide biosynthetic process
DXY21_RS11340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY21_RS11340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY21_RS11345	COG0490	domain, Protein
DXY21_RS11350	COG5416	Lipopolysaccharide assembly protein A domain
DXY21_RS11355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DXY21_RS11355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DXY21_RS11365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DXY21_RS11375	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS11375	COG4991	sh3 domain protein
DXY21_RS11375	COG3103	Sh3 type 3 domain protein
DXY21_RS11400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DXY21_RS11405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DXY21_RS11410	COG1959	2 iron, 2 sulfur cluster binding
DXY21_RS11415	COG1104	cysteine desulfurase activity
DXY21_RS11425	COG0457	Tetratricopeptide repeat
DXY21_RS11430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DXY21_RS11435	COG3881	PFAM PRC-barrel domain
DXY21_RS11450	COG0765	amino acid transport
DXY21_RS11455	COG0765	amino acid transport
DXY21_RS11460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS11465	COG1126	abc transporter atp-binding protein
DXY21_RS11470	COG0628	permease
DXY21_RS11480	COG4472	Bacterial protein of unknown function (DUF965)
DXY21_RS11495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY21_RS11525	COG0768	penicillin binding
DXY21_RS11550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY21_RS11555	COG0626	cystathionine gamma-synthase activity
DXY21_RS11565	COG2427	Protein of unknown function (DUF1641)
DXY21_RS11570	COG3383	formate dehydrogenase (NAD+) activity
DXY21_RS11575	COG5609	conserved protein (DUF2294)
DXY21_RS11580	COG2116	formate transmembrane transporter activity
DXY21_RS11590	COG2226	methyltransferase
DXY21_RS11595	COG1309	transcriptional regulator
DXY21_RS11600	COG2124	cytochrome p450
DXY21_RS11600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY21_RS11605	COG2814	Major facilitator Superfamily
DXY21_RS11610	COG0583	DNA-binding transcription factor activity
DXY21_RS11615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DXY21_RS11625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS11625	COG3711	transcriptional antiterminator
DXY21_RS11630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS11630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY21_RS11630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY21_RS11635	COG1482	cell wall glycoprotein biosynthetic process
DXY21_RS11645	COG0561	phosphatase activity
DXY21_RS11650	COG0561	phosphatase activity
DXY21_RS11660	COG2318	DinB family
DXY21_RS11665	COG0456	acetyltransferase
DXY21_RS11675	COG2814	Major facilitator Superfamily
DXY21_RS11685	COG0563	adenylate kinase activity
DXY21_RS11690	COG3708	Transcriptional regulator
DXY21_RS11690	COG2207	Transcriptional regulator
DXY21_RS11715	COG0398	Pfam SNARE associated Golgi protein
DXY21_RS11720	COG0726	polysaccharide deacetylase
DXY21_RS11725	COG2755	lipolytic protein G-D-S-L family
DXY21_RS11735	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DXY21_RS11740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY21_RS11745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DXY21_RS11750	COG1534	Rna-binding protein
DXY21_RS11760	COG1713	HD superfamily hydrolase involved in NAD metabolism
DXY21_RS11765	COG0799	negative regulation of ribosome biogenesis
DXY21_RS11770	COG2226	methyltransferase
DXY21_RS11775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY21_RS11780	COG1596	polysaccharide export
DXY21_RS11780	COG1555	photosystem II stabilization
DXY21_RS11785	COG2131	deaminase
DXY21_RS11790	COG2333	competence protein COMEC
DXY21_RS11790	COG0658	competence protein
DXY21_RS11805	COG1466	dna polymerase III delta subunit
DXY21_RS11820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS11835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY21_RS11865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DXY21_RS11870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DXY21_RS11875	COG1283	sodium-dependent phosphate transmembrane transporter activity
DXY21_RS11880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DXY21_RS11885	COG1610	YqeY-like protein
DXY21_RS11890	COG1030	water channel activity
DXY21_RS11895	COG4864	UPF0365 protein
DXY21_RS11910	COG0561	phosphatase activity
DXY21_RS11915	COG1702	phosphate starvation-inducible protein PhoH
DXY21_RS11920	COG1480	7TM receptor with intracellular HD hydrolase
DXY21_RS11930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DXY21_RS11935	COG0295	cytidine deaminase activity
DXY21_RS11940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DXY21_RS11960	COG0751	glycine-tRNA ligase activity
DXY21_RS11965	COG0517	IMP dehydrogenase activity
DXY21_RS11980	COG0358	DNA primase activity
DXY21_RS11985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DXY21_RS11990	COG2010	Cytochrome c
DXY21_RS11995	COG2384	SAM-dependent methyltransferase
DXY21_RS12000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DXY21_RS12015	COG0513	Belongs to the DEAD box helicase family
DXY21_RS12030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS12035	COG0735	belongs to the Fur family
DXY21_RS12040	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DXY21_RS12045	COG4709	membrane
DXY21_RS12055	COG1388	LysM domain
DXY21_RS12060	COG5521	maltodextrose utilization protein MalA
DXY21_RS12065	COG2839	Protein conserved in bacteria
DXY21_RS12070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY21_RS12075	COG0477	Major facilitator Superfamily
DXY21_RS12085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DXY21_RS12090	COG0573	inorganic phosphate transmembrane transporter activity
DXY21_RS12095	COG0581	inorganic phosphate transmembrane transporter activity
DXY21_RS12100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY21_RS12105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY21_RS12110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY21_RS12120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DXY21_RS12125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DXY21_RS12135	COG1757	Na H antiporter
DXY21_RS12140	COG4483	Protein conserved in bacteria
DXY21_RS12145	COG1940	carbohydrate kinase activity
DXY21_RS12150	COG2866	Carboxypeptidase
DXY21_RS12160	COG0011	TIGRFAM Protein of
DXY21_RS12170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS12180	COG1393	Belongs to the ArsC family
DXY21_RS12190	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS12195	COG1253	flavin adenine dinucleotide binding
DXY21_RS12200	COG0598	Magnesium transport protein CorA
DXY21_RS12205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DXY21_RS12210	COG1459	type II secretion system
DXY21_RS12215	COG4537	Required for transformation and DNA binding
DXY21_RS12220	COG4970	Tfp pilus assembly protein FimT
DXY21_RS12230	COG4940	Competence protein ComGF
DXY21_RS12255	COG0681	Belongs to the peptidase S26 family
DXY21_RS12265	COG1396	sequence-specific DNA binding
DXY21_RS12280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY21_RS12300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY21_RS12315	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY21_RS12325	COG3872	metal-dependent enzyme
DXY21_RS12335	COG0006	proline dipeptidase activity
DXY21_RS12350	COG3854	ATPases associated with a variety of cellular activities
DXY21_RS12390	COG0511	ligase activity, forming carbon-carbon bonds
DXY21_RS12395	COG0439	Biotin carboxylase
DXY21_RS12400	COG1302	Protein conserved in bacteria
DXY21_RS12415	COG1570	exodeoxyribonuclease VII activity
DXY21_RS12425	COG0142	geranyltranstransferase activity
DXY21_RS12435	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DXY21_RS12445	COG0497	DNA recombination
DXY21_RS12450	COG0750	zinc metalloprotease
DXY21_RS12455	COG0745	RESPONSE REGULATOR receiver
DXY21_RS12460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY21_RS12475	COG1902	pentaerythritol trinitrate reductase activity
DXY21_RS12495	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS12500	COG0584	glycerophosphoryl diester phosphodiesterase
DXY21_RS12505	COG0183	Belongs to the thiolase family
DXY21_RS12510	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY21_RS12515	COG1960	acyl-CoA dehydrogenase activity
DXY21_RS12520	COG0372	Belongs to the citrate synthase family
DXY21_RS12525	COG2079	MmgE PrpD family protein
DXY21_RS12530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DXY21_RS12540	COG3290	protein histidine kinase activity
DXY21_RS12540	COG3829	transcription factor binding
DXY21_RS12545	COG0280	phosphate acetyltransferase
DXY21_RS12550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY21_RS12555	COG3426	butyrate kinase activity
DXY21_RS12560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY21_RS12565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY21_RS12570	COG0022	dehydrogenase e1 component
DXY21_RS12575	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY21_RS12580	COG1597	lipid kinase activity
DXY21_RS12590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY21_RS12595	COG0765	amino acid transport
DXY21_RS12600	COG1126	abc transporter atp-binding protein
DXY21_RS12605	COG4129	membrane
DXY21_RS12610	COG1376	ErfK ybiS ycfS ynhG family protein
DXY21_RS12620	COG0346	lactoylglutathione lyase activity
DXY21_RS12625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY21_RS12630	COG2195	Cleaves the N-terminal amino acid of tripeptides
DXY21_RS12635	COG0706	membrane insertase activity
DXY21_RS12650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DXY21_RS12655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DXY21_RS12670	COG0596	Alpha beta hydrolase
DXY21_RS12690	COG0250	Participates in transcription elongation, termination and antitermination
DXY21_RS12695	COG2070	2-Nitropropane dioxygenase
DXY21_RS12695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY21_RS12710	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS12715	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS12720	COG3321	synthase
DXY21_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS12725	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS12725	COG0300	oxidoreductase activity
DXY21_RS12725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12725	COG3321	synthase
DXY21_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS12730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS12730	COG3321	synthase
DXY21_RS12730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12735	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12735	COG0300	oxidoreductase activity
DXY21_RS12735	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS12735	COG3321	synthase
DXY21_RS12740	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS12740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12740	COG0300	oxidoreductase activity
DXY21_RS12740	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12740	COG3321	synthase
DXY21_RS12745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS12745	COG3321	synthase
DXY21_RS12745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS12750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS12750	COG3321	synthase
DXY21_RS12750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS12755	COG2124	cytochrome p450
DXY21_RS12760	COG3425	synthase
DXY21_RS12765	COG1024	Enoyl-CoA hydratase
DXY21_RS12770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY21_RS12775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS12780	COG0300	oxidoreductase activity
DXY21_RS12785	COG3048	D-serine ammonia-lyase activity
DXY21_RS12795	COG0346	lactoylglutathione lyase activity
DXY21_RS12805	COG0628	permease
DXY21_RS12820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY21_RS12825	COG0456	acetyltransferase
DXY21_RS12830	COG2329	Antibiotic biosynthesis monooxygenase
DXY21_RS12835	COG0456	acetyltransferase
DXY21_RS12835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DXY21_RS12840	COG4918	Iron-sulphur cluster biosynthesis
DXY21_RS12850	COG1073	alpha beta
DXY21_RS12860	COG0667	Aldo Keto reductase
DXY21_RS12870	COG0494	nUDIX hydrolase
DXY21_RS12875	COG1379	DNA repair
DXY21_RS12880	COG1396	sequence-specific DNA binding
DXY21_RS12885	COG0252	asparaginase activity
DXY21_RS12890	COG1027	Aspartate ammonia-lyase
DXY21_RS12895	COG1757	Na H antiporter
DXY21_RS12900	COG0281	malic enzyme
DXY21_RS12915	COG1300	Membrane
DXY21_RS12920	COG0735	belongs to the Fur family
DXY21_RS12930	COG4974	Belongs to the 'phage' integrase family
DXY21_RS12935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DXY21_RS12940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DXY21_RS12945	COG1686	Belongs to the peptidase S11 family
DXY21_RS12950	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS12960	COG1191	sigma factor activity
DXY21_RS12980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY21_RS12995	COG0697	spore germination
DXY21_RS13000	COG0019	diaminopimelate decarboxylase activity
DXY21_RS13005	COG4086	secreted protein
DXY21_RS13010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DXY21_RS13020	COG0681	Belongs to the peptidase S26 family
DXY21_RS13030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY21_RS13030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY21_RS13035	COG0307	riboflavin synthase, alpha
DXY21_RS13050	COG0456	acetyltransferase
DXY21_RS13055	COG1547	Domain of unknown function (DUF309)
DXY21_RS13080	COG1686	Belongs to the peptidase S11 family
DXY21_RS13085	COG2715	membrane protein required for spore maturation
DXY21_RS13090	COG0700	Nucleoside recognition
DXY21_RS13095	COG1187	pseudouridine synthase activity
DXY21_RS13100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS13105	COG1333	cytochrome c biogenesis protein
DXY21_RS13110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY21_RS13115	COG0745	RESPONSE REGULATOR receiver
DXY21_RS13120	COG5002	protein histidine kinase activity
DXY21_RS13125	COG1595	DNA-templated transcription, initiation
DXY21_RS13135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY21_RS13140	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DXY21_RS13145	COG1141	Ferredoxin
DXY21_RS13150	COG4955	Helix-turn-helix domain
DXY21_RS13155	COG0514	ATP-dependent DNA helicase (RecQ)
DXY21_RS13160	COG1266	CAAX protease self-immunity
DXY21_RS13165	COG1388	LysM domain
DXY21_RS13175	COG1408	metallophosphoesterase
DXY21_RS13180	COG4862	establishment of competence for transformation
DXY21_RS13185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY21_RS13190	COG0492	ferredoxin-NADP+ reductase activity
DXY21_RS13195	COG2339	peptidase activity
DXY21_RS13200	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS13200	COG3773	Cell wall hydrolase
DXY21_RS13205	COG2959	enzyme of heme biosynthesis
DXY21_RS13210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DXY21_RS13225	COG0539	negative regulation of cytoplasmic translation
DXY21_RS13265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY21_RS13270	COG0776	regulation of translation
DXY21_RS13285	COG0142	geranyltranstransferase activity
DXY21_RS13295	COG0142	geranyltranstransferase activity
DXY21_RS13300	COG0105	UTP biosynthetic process
DXY21_RS13305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DXY21_RS13320	COG4401	Chorismate mutase type I
DXY21_RS13325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY21_RS13360	COG0287	Prephenate dehydrogenase
DXY21_RS13370	COG0457	Tetratricopeptide repeat
DXY21_RS13385	COG0723	plastoquinol--plastocyanin reductase activity
DXY21_RS13390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY21_RS13395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY21_RS13395	COG2010	Cytochrome c
DXY21_RS13400	COG4347	Protein of unknown function (DUF1405)
DXY21_RS13410	COG2140	Oxalate decarboxylase
DXY21_RS13415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS13420	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY21_RS13435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY21_RS13440	COG0438	transferase activity, transferring glycosyl groups
DXY21_RS13470	COG1199	ATP-dependent helicase activity
DXY21_RS13470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DXY21_RS13480	COG5353	protein conserved in bacteria
DXY21_RS13485	COG0436	Aminotransferase
DXY21_RS13495	COG3935	DnaD domain protein
DXY21_RS13500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DXY21_RS13510	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY21_RS13510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY21_RS13550	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY21_RS13555	COG2190	(PTS) system
DXY21_RS13560	COG1111	helicase
DXY21_RS13560	COG1205	dead DEAH box helicase
DXY21_RS13565	COG3359	exonuclease
DXY21_RS13595	COG0116	Belongs to the methyltransferase superfamily
DXY21_RS13610	COG1199	ATP-dependent helicase activity
DXY21_RS13615	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DXY21_RS13625	COG2233	PERMEase
DXY21_RS13635	COG1335	isochorismatase
DXY21_RS13660	COG3424	synthase
DXY21_RS13665	COG1755	Isoprenylcysteine carboxyl methyltransferase
DXY21_RS13675	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY21_RS13690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY21_RS13700	COG0328	RNA-DNA hybrid ribonuclease activity
DXY21_RS13705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DXY21_RS13710	COG0328	RNA-DNA hybrid ribonuclease activity
DXY21_RS13730	COG1278	Cold shock
DXY21_RS13740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY21_RS13750	COG0386	Belongs to the glutathione peroxidase family
DXY21_RS13755	COG1418	mRNA catabolic process
DXY21_RS13760	COG1413	lyase activity
DXY21_RS13775	COG2521	methyltransferase
DXY21_RS13775	COG2136	Putative SAM-dependent methyltransferase
DXY21_RS13790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY21_RS13795	COG0204	Acyl-transferase
DXY21_RS13800	COG1272	protein, Hemolysin III
DXY21_RS13805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DXY21_RS13810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DXY21_RS13820	COG1999	signal sequence binding
DXY21_RS13825	COG2755	lipolytic protein G-D-S-L family
DXY21_RS13830	COG4698	Protein conserved in bacteria
DXY21_RS13835	COG1846	Transcriptional regulator
DXY21_RS13855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY21_RS13870	COG1525	nuclease
DXY21_RS13875	COG4282	regulation of fungal-type cell wall biogenesis
DXY21_RS13895	COG4585	Histidine kinase
DXY21_RS13900	COG2197	response regulator
DXY21_RS13930	COG0457	Tetratricopeptide repeat
DXY21_RS13935	COG1388	LysM domain
DXY21_RS13970	COG4641	Protein conserved in bacteria
DXY21_RS13985	COG0463	Glycosyl transferase, family 2
DXY21_RS13990	COG0456	acetyltransferase
DXY21_RS14005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY21_RS14010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY21_RS14015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY21_RS14020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY21_RS14025	COG0456	acetyltransferase
DXY21_RS14030	COG1509	lysine 2,3-aminomutase activity
DXY21_RS14035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY21_RS14040	COG1525	nuclease
DXY21_RS14045	COG4282	regulation of fungal-type cell wall biogenesis
DXY21_RS14055	COG5444	nuclease activity
DXY21_RS14085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY21_RS14090	COG0457	Tetratricopeptide repeat
DXY21_RS14110	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS14110	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS14115	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS14130	COG2433	Pfam Transposase IS66
DXY21_RS14140	COG0739	heme binding
DXY21_RS14140	COG1196	nuclear chromosome segregation
DXY21_RS14140	COG0741	lytic transglycosylase activity
DXY21_RS14290	COG0776	regulation of translation
DXY21_RS14385	COG3655	Transcriptional regulator
DXY21_RS14485	COG3655	Transcriptional regulator
DXY21_RS14565	COG1793	dna ligase
DXY21_RS14570	COG2135	peptidase activity
DXY21_RS14595	COG4195	phage-related replication protein
DXY21_RS14600	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS14600	COG3420	alginic acid biosynthetic process
DXY21_RS14620	COG2887	Belongs to the helicase family. UvrD subfamily
DXY21_RS14630	COG0305	Participates in initiation and elongation during chromosome replication
DXY21_RS14635	COG0358	DNA primase activity
DXY21_RS14640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DXY21_RS14645	COG0587	DNA-directed DNA polymerase activity
DXY21_RS14650	COG3584	3D domain protein
DXY21_RS14660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DXY21_RS14770	COG1780	Probably involved in ribonucleotide reductase function
DXY21_RS14775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY21_RS14805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS14810	COG0756	dUTP diphosphatase activity
DXY21_RS14845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY21_RS14880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DXY21_RS14920	COG3331	DNA recombination
DXY21_RS14925	COG2337	Toxic component of a toxin-antitoxin (TA) module
DXY21_RS14965	COG0671	phosphoesterase, PA-phosphatase related
DXY21_RS14985	COG1876	peptidase activity
DXY21_RS14995	COG2226	methyltransferase
DXY21_RS15000	COG0793	Belongs to the peptidase S41A family
DXY21_RS15000	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS15005	COG2188	Transcriptional regulator
DXY21_RS15010	COG2723	6-phospho-beta-galactosidase activity
DXY21_RS15020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY21_RS15030	COG0346	lactoylglutathione lyase activity
DXY21_RS15035	COG0400	carboxylic ester hydrolase activity
DXY21_RS15040	COG0778	Nitroreductase
DXY21_RS15045	COG1733	regulation of RNA biosynthetic process
DXY21_RS15055	COG1942	4-Oxalocrotonate Tautomerase
DXY21_RS15070	COG2962	Rard protein
DXY21_RS15080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY21_RS15085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY21_RS15090	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS15095	COG0534	Mate efflux family protein
DXY21_RS15100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY21_RS15105	COG1819	glycosyl
DXY21_RS15110	COG1388	LysM domain
DXY21_RS15110	COG0791	NLP P60 protein
DXY21_RS15115	COG2032	superoxide dismutase activity
DXY21_RS15120	COG0714	Associated with various cellular activities
DXY21_RS15125	COG4548	von Willebrand factor, type A
DXY21_RS15135	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY21_RS15140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS15145	COG0385	Bile acid
DXY21_RS15150	COG0733	neurotransmitter:sodium symporter activity
DXY21_RS15155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY21_RS15160	COG1657	PFAM Prenyltransferase squalene oxidase
DXY21_RS15165	COG1012	belongs to the aldehyde dehydrogenase family
DXY21_RS15195	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY21_RS15210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY21_RS15215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DXY21_RS15225	COG0514	ATP-dependent DNA helicase (RecQ)
DXY21_RS15230	COG3584	3D domain protein
DXY21_RS15230	COG1388	LysM domain
DXY21_RS15240	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY21_RS15255	COG2322	membrane
DXY21_RS15260	COG0741	lytic transglycosylase activity
DXY21_RS15265	COG0640	Transcriptional regulator
DXY21_RS15275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY21_RS15280	COG1309	transcriptional regulator
DXY21_RS15290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY21_RS15295	COG1733	regulation of RNA biosynthetic process
DXY21_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS15320	COG0243	molybdopterin cofactor binding
DXY21_RS15325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY21_RS15330	COG1070	Carbohydrate kinase
DXY21_RS15335	COG2814	Major facilitator Superfamily
DXY21_RS15345	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY21_RS15350	COG0300	oxidoreductase activity
DXY21_RS15365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY21_RS15370	COG0583	DNA-binding transcription factor activity
DXY21_RS15375	COG0070	glutamate synthase
DXY21_RS15375	COG0069	glutamate synthase activity
DXY21_RS15375	COG0067	glutamate synthase
DXY21_RS15380	COG0493	'glutamate synthase
DXY21_RS15385	COG0604	alcohol dehydrogenase
DXY21_RS15400	COG0640	Transcriptional regulator
DXY21_RS15405	COG2814	Major facilitator Superfamily
DXY21_RS15410	COG0405	Gamma-glutamyltransferase
DXY21_RS15415	COG0166	Belongs to the GPI family
DXY21_RS15420	COG0582	viral genome integration into host DNA
DXY21_RS15435	COG0534	Mate efflux family protein
DXY21_RS15440	COG2017	converts alpha-aldose to the beta-anomer
DXY21_RS15445	COG2027	D-alanyl-D-alanine carboxypeptidase
DXY21_RS15450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS15455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS15460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS15465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS15470	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY21_RS15470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS15480	COG1649	PFAM Uncharacterised BCR, COG1649
DXY21_RS15485	COG1960	acyl-CoA dehydrogenase activity
DXY21_RS15490	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS15495	COG0439	Biotin carboxylase
DXY21_RS15500	COG0511	ligase activity, forming carbon-carbon bonds
DXY21_RS15505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DXY21_RS15510	COG1024	Enoyl-CoA hydratase
DXY21_RS15515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY21_RS15520	COG0586	Pfam SNARE associated Golgi protein
DXY21_RS15525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY21_RS15530	COG2246	polysaccharide biosynthetic process
DXY21_RS15540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY21_RS15555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DXY21_RS15560	COG2124	cytochrome p450
DXY21_RS15565	COG2610	gluconate transmembrane transporter activity
DXY21_RS15570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY21_RS15575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY21_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS15605	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY21_RS15615	COG0745	RESPONSE REGULATOR receiver
DXY21_RS15620	COG2205	protein histidine kinase activity
DXY21_RS15655	COG2271	Major facilitator Superfamily
DXY21_RS15660	COG1609	Transcriptional regulator
DXY21_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS15670	COG1312	Catalyzes the dehydration of D-mannonate
DXY21_RS15675	COG0800	Aldolase
DXY21_RS15680	COG1063	alcohol dehydrogenase
DXY21_RS15690	COG1115	amino acid carrier protein
DXY21_RS15700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY21_RS15705	COG0187	DNA topoisomerase II activity
DXY21_RS15710	COG1832	CoA-binding protein
DXY21_RS15720	COG4841	protein insertion into membrane
DXY21_RS15730	COG0824	Thioesterase
DXY21_RS15750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS15755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DXY21_RS15770	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY21_RS15780	COG4846	Membrane protein involved in cytochrome C biogenesis
DXY21_RS15785	COG2201	protein-glutamate methylesterase activity
DXY21_RS15790	COG0785	Cytochrome C biogenesis protein
DXY21_RS15810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DXY21_RS15820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY21_RS15850	COG4195	phage-related replication protein
DXY21_RS15855	COG0756	dUTP diphosphatase activity
DXY21_RS15860	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS15885	COG3397	chitin binding
DXY21_RS15915	COG1064	alcohol dehydrogenase
DXY21_RS15935	COG3848	Pyruvate phosphate dikinase
DXY21_RS15935	COG0574	Belongs to the PEP-utilizing enzyme family
DXY21_RS15940	COG1070	Carbohydrate kinase
DXY21_RS15955	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY21_RS15960	COG2211	Major facilitator Superfamily
DXY21_RS15970	COG0174	glutamine synthetase
DXY21_RS15975	COG0789	Transcriptional regulator
DXY21_RS15980	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DXY21_RS15985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DXY21_RS15990	COG0464	growth
DXY21_RS16000	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS16005	COG4112	unkown
DXY21_RS16010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY21_RS16015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY21_RS16055	COG2076	Multidrug Resistance protein
DXY21_RS16065	COG1764	response to oxidative stress
DXY21_RS16070	COG4195	phage-related replication protein
DXY21_RS16080	COG1404	Belongs to the peptidase S8 family
DXY21_RS16090	COG3619	membrane
DXY21_RS16095	COG3209	COG3209 Rhs family protein
DXY21_RS16100	COG2124	cytochrome p450
DXY21_RS16105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY21_RS16105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DXY21_RS16105	COG3321	synthase
DXY21_RS16105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS16110	COG3321	synthase
DXY21_RS16110	COG4221	oxidoreductase activity
DXY21_RS16110	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS16115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS16115	COG3321	synthase
DXY21_RS16115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS16115	COG3321	synthase
DXY21_RS16115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY21_RS16115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS16115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16120	COG0300	oxidoreductase activity
DXY21_RS16120	COG3321	synthase
DXY21_RS16120	COG4221	oxidoreductase activity
DXY21_RS16120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16125	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS16125	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS16125	COG0300	oxidoreductase activity
DXY21_RS16125	COG3321	synthase
DXY21_RS16125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS16130	COG1024	Enoyl-CoA hydratase
DXY21_RS16135	COG1024	Enoyl-CoA hydratase
DXY21_RS16140	COG3425	synthase
DXY21_RS16145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16190	COG4550	Control of competence regulator ComK, YlbF/YmcA
DXY21_RS16210	COG2359	stage V sporulation protein S
DXY21_RS16215	COG1692	metallophosphoesterase
DXY21_RS16225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY21_RS16240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DXY21_RS16245	COG1426	Protein conserved in bacteria
DXY21_RS16260	COG0300	oxidoreductase activity
DXY21_RS16265	COG0612	Peptidase, M16
DXY21_RS16270	COG0612	Peptidase, M16
DXY21_RS16275	COG1033	growth of symbiont in host cell
DXY21_RS16275	COG2409	Drug exporters of the RND superfamily
DXY21_RS16280	COG1846	Transcriptional regulator
DXY21_RS16285	COG2814	Major facilitator Superfamily
DXY21_RS16290	COG2188	Transcriptional regulator
DXY21_RS16295	COG4980	gas vesicle protein
DXY21_RS16295	COG1674	ftsk spoiiie
DXY21_RS16305	COG0740	serine-type endopeptidase activity
DXY21_RS16310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY21_RS16320	COG0527	aspartate kinase activity
DXY21_RS16325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DXY21_RS16330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY21_RS16335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY21_RS16340	COG1873	PFAM PRC-barrel domain
DXY21_RS16345	COG0612	Peptidase, M16
DXY21_RS16350	COG0726	polysaccharide deacetylase
DXY21_RS16365	COG0196	riboflavin kinase activity
DXY21_RS16380	COG1550	Protein conserved in bacteria
DXY21_RS16390	COG1358	cellular component organization or biogenesis
DXY21_RS16395	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DXY21_RS16400	COG0195	Participates in both transcription termination and antitermination
DXY21_RS16410	COG2176	DNA-directed DNA polymerase activity
DXY21_RS16420	COG0750	zinc metalloprotease
DXY21_RS16430	COG4589	Belongs to the CDS family
DXY21_RS16435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DXY21_RS16465	COG1191	sigma factor activity
DXY21_RS16475	COG1776	CheC inhibitor of MCP methylation
DXY21_RS16480	COG0835	chemotaxis
DXY21_RS16485	COG0643	Histidine kinase
DXY21_RS16485	COG2198	Histidine kinase
DXY21_RS16490	COG2201	protein-glutamate methylesterase activity
DXY21_RS16495	COG0455	bacterial-type flagellum organization
DXY21_RS16500	COG1419	protein localization to endoplasmic reticulum
DXY21_RS16505	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY21_RS16510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY21_RS16515	COG1684	flagellar biosynthetic protein fliR
DXY21_RS16520	COG1987	bacterial-type flagellum assembly
DXY21_RS16525	COG1338	Plays a role in the flagellum-specific transport system
DXY21_RS16530	COG3190	flagellar
DXY21_RS16535	COG2201	protein-glutamate methylesterase activity
DXY21_RS16540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY21_RS16540	COG1776	CheC inhibitor of MCP methylation
DXY21_RS16545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY21_RS16550	COG1580	Controls the rotational direction of flagella during chemotaxis
DXY21_RS16555	COG1582	Flagellar protein (FlbD)
DXY21_RS16560	COG4786	Flagellar basal body rod
DXY21_RS16565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DXY21_RS16570	COG3144	bacterial-type flagellum assembly
DXY21_RS16575	COG3334	PFAM MgtE intracellular
DXY21_RS16580	COG2882	bacterial-type flagellum organization
DXY21_RS16585	COG1157	protein secretion by the type III secretion system
DXY21_RS16590	COG1317	bacterial-type flagellum organization
DXY21_RS16595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY21_RS16600	COG1766	The M ring may be actively involved in energy transduction
DXY21_RS16605	COG1677	Flagellar hook-basal body complex protein FliE
DXY21_RS16610	COG1558	bacterial-type flagellum-dependent cell motility
DXY21_RS16615	COG1815	bacterial-type flagellum-dependent cell motility
DXY21_RS16635	COG4974	Belongs to the 'phage' integrase family
DXY21_RS16645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY21_RS16650	COG0758	DNA mediated transformation
DXY21_RS16655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DXY21_RS16665	COG2257	FlhB HrpN YscU SpaS Family
DXY21_RS16680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY21_RS16705	COG1837	Belongs to the UPF0109 family
DXY21_RS16715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DXY21_RS16730	COG0552	protein localization to endoplasmic reticulum
DXY21_RS16735	COG1196	nuclear chromosome segregation
DXY21_RS16745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS16755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY21_RS16770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DXY21_RS16775	COG1760	l-serine dehydratase
DXY21_RS16780	COG1760	l-serine dehydratase
DXY21_RS16785	COG1461	Dihydroxyacetone kinase
DXY21_RS16790	COG1302	Protein conserved in bacteria
DXY21_RS16805	COG1564	THIamine pyrophosphokinase
DXY21_RS16810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DXY21_RS16820	COG2815	serine threonine protein kinase
DXY21_RS16820	COG0515	serine threonine protein kinase
DXY21_RS16825	COG0631	protein serine/threonine phosphatase activity
DXY21_RS16835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DXY21_RS16835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DXY21_RS16845	COG0242	peptide deformylase activity
DXY21_RS16850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY21_RS16855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY21_RS16865	COG0194	GDP metabolic process
DXY21_RS16870	COG2052	Domain of unknown function (DUF370)
DXY21_RS16875	COG1561	YicC-like family, N-terminal region
DXY21_RS16880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DXY21_RS16890	COG1648	precorrin-2 dehydrogenase activity
DXY21_RS16895	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DXY21_RS16900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY21_RS16915	COG0306	phosphate transporter
DXY21_RS16925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DXY21_RS16930	COG0284	orotidine-5'-phosphate decarboxylase activity
DXY21_RS16945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY21_RS16950	COG0505	Belongs to the CarA family
DXY21_RS16955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DXY21_RS16965	COG2233	PERMEase
DXY21_RS16975	COG0564	pseudouridine synthase activity
DXY21_RS16985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY21_RS16990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DXY21_RS16995	COG3599	regulation of cell shape
DXY21_RS17000	COG2302	S4 RNA-binding domain
DXY21_RS17005	COG0762	integral membrane protein
DXY21_RS17015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DXY21_RS17025	COG1873	PFAM PRC-barrel domain
DXY21_RS17030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY21_RS17035	COG1119	ATPase activity
DXY21_RS17040	COG1191	sigma factor activity
DXY21_RS17045	COG1191	sigma factor activity
DXY21_RS17055	COG4412	M6 family metalloprotease domain protein
DXY21_RS17055	COG1404	Belongs to the peptidase S8 family
DXY21_RS17060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DXY21_RS17065	COG0849	cell division
DXY21_RS17070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DXY21_RS17085	COG0772	Belongs to the SEDS family
DXY21_RS17105	COG0768	penicillin binding
DXY21_RS17115	COG4839	cell division protein FtsL
DXY21_RS17135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY21_RS17150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DXY21_RS17155	COG1399	metal-binding, possibly nucleic acid-binding protein
DXY21_RS17165	COG3480	Lon protease (S16) C-terminal proteolytic domain
DXY21_RS17170	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY21_RS17175	COG3314	Sporulation integral membrane protein YlbJ
DXY21_RS17185	COG0742	ribosomal rna small subunit methyltransferase
DXY21_RS17200	COG3679	Belongs to the UPF0342 family
DXY21_RS17215	COG2340	Cysteine-rich secretory protein family
DXY21_RS17220	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DXY21_RS17230	COG3336	cytochrome c oxidase
DXY21_RS17235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DXY21_RS17240	COG1845	cytochrome c oxidase, subunit III
DXY21_RS17245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY21_RS17250	COG2010	Cytochrome c
DXY21_RS17250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY21_RS17265	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DXY21_RS17270	COG0772	Belongs to the SEDS family
DXY21_RS17280	COG2066	Belongs to the glutaminase family
DXY21_RS17285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY21_RS17290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DXY21_RS17300	COG4896	Protein conserved in bacteria
DXY21_RS17330	COG1595	DNA-templated transcription, initiation
DXY21_RS17345	COG3227	Zinc metalloprotease (Elastase)
DXY21_RS17355	COG0483	inositol monophosphate 1-phosphatase activity
DXY21_RS17375	COG1982	Orn Lys Arg decarboxylase major
DXY21_RS17390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS17395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY21_RS17400	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY21_RS17405	COG0022	dehydrogenase e1 component
DXY21_RS17410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY21_RS17415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY21_RS17420	COG3321	synthase
DXY21_RS17420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS17420	COG4221	oxidoreductase activity
DXY21_RS17425	COG4221	oxidoreductase activity
DXY21_RS17425	COG3321	synthase
DXY21_RS17425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS17425	COG0300	oxidoreductase activity
DXY21_RS17430	COG3321	synthase
DXY21_RS17430	COG4221	oxidoreductase activity
DXY21_RS17430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS17430	COG0300	oxidoreductase activity
DXY21_RS17435	COG4221	oxidoreductase activity
DXY21_RS17435	COG0300	oxidoreductase activity
DXY21_RS17435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS17435	COG3321	synthase
DXY21_RS17440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS17440	COG3321	synthase
DXY21_RS17440	COG4221	oxidoreductase activity
DXY21_RS17445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY21_RS17445	COG4221	oxidoreductase activity
DXY21_RS17445	COG3321	synthase
DXY21_RS17445	COG0300	oxidoreductase activity
DXY21_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS17450	COG3321	synthase
DXY21_RS17450	COG4221	oxidoreductase activity
DXY21_RS17450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY21_RS17460	COG0497	DNA recombination
DXY21_RS17470	COG0242	peptide deformylase activity
DXY21_RS17475	COG0561	phosphatase activity
DXY21_RS17485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY21_RS17495	COG0569	domain protein
DXY21_RS17500	COG2105	PFAM AIG2 family protein
DXY21_RS17500	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DXY21_RS17505	COG3852	Histidine kinase
DXY21_RS17510	COG2002	toxin-antitoxin pair type II binding
DXY21_RS17515	COG1077	Cell shape determining protein MreB Mrl
DXY21_RS17525	COG2309	aminopeptidase activity
DXY21_RS17530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY21_RS17535	COG0488	(ABC) transporter
DXY21_RS17545	COG0681	Belongs to the peptidase S26 family
DXY21_RS17550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY21_RS17550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS17550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY21_RS17555	COG1105	Belongs to the carbohydrate kinase PfkB family
DXY21_RS17560	COG1349	DNA-binding transcription factor activity
DXY21_RS17565	COG0577	efflux transmembrane transporter activity
DXY21_RS17570	COG1136	(ABC) transporter
DXY21_RS17575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DXY21_RS17585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DXY21_RS17590	COG0314	molybdopterin synthase activity
DXY21_RS17595	COG1763	Mo-molybdopterin cofactor biosynthetic process
DXY21_RS17600	COG0303	'Molybdopterin
DXY21_RS17605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY21_RS17625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS17630	COG0668	transmembrane transport
DXY21_RS17650	COG0716	FMN binding
DXY21_RS17660	COG0716	FMN binding
DXY21_RS17665	COG0583	DNA-binding transcription factor activity
DXY21_RS17670	COG0517	IMP dehydrogenase activity
DXY21_RS17680	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DXY21_RS17685	COG4703	Protein of unknown function (DUF1797)
DXY21_RS17690	COG2200	EAL domain
DXY21_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS17710	COG1408	metallophosphoesterase
DXY21_RS17715	COG1376	ErfK ybiS ycfS ynhG family protein
DXY21_RS17720	COG2814	Major facilitator Superfamily
DXY21_RS17730	COG0784	Response regulator, receiver
DXY21_RS17730	COG0835	chemotaxis
DXY21_RS17735	COG0436	Aminotransferase
DXY21_RS17740	COG4191	Histidine kinase
DXY21_RS17745	COG0768	penicillin binding
DXY21_RS17750	COG2340	Cysteine-rich secretory protein family
DXY21_RS17755	COG2084	Dehydrogenase
DXY21_RS17760	COG0840	transmembrane signaling receptor activity
DXY21_RS17765	COG1533	DNA photolyase activity
DXY21_RS17775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DXY21_RS17780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY21_RS17785	COG2190	(PTS) system
DXY21_RS17785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY21_RS17785	COG1263	PTS System
DXY21_RS17790	COG3711	transcriptional antiterminator
DXY21_RS17795	COG1609	Transcriptional regulator
DXY21_RS17800	COG0006	proline dipeptidase activity
DXY21_RS17805	COG2217	Heavy metal translocating P-type atpase
DXY21_RS17810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY21_RS17815	COG2244	polysaccharide biosynthetic process
DXY21_RS17820	COG3773	Cell wall hydrolase
DXY21_RS17830	COG4873	Protein conserved in bacteria
DXY21_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS17855	COG1733	regulation of RNA biosynthetic process
DXY21_RS17865	COG0602	queuosine metabolic process
DXY21_RS17870	COG0720	synthase
DXY21_RS17885	COG3949	Membrane
DXY21_RS17890	COG0542	response to heat
DXY21_RS17895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY21_RS17900	COG1360	Flagellar Motor Protein
DXY21_RS17905	COG1846	Transcriptional regulator
DXY21_RS17910	COG3852	Histidine kinase
DXY21_RS17940	COG0436	Aminotransferase
DXY21_RS17945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY21_RS17960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY21_RS17965	COG5002	protein histidine kinase activity
DXY21_RS17970	COG3594	Acyltransferase
DXY21_RS17980	COG2323	membrane
DXY21_RS17985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DXY21_RS18010	COG1191	sigma factor activity
DXY21_RS18015	COG0861	Integral membrane protein TerC family
DXY21_RS18020	COG0586	Pfam SNARE associated Golgi protein
DXY21_RS18025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DXY21_RS18030	COG3285	dna ligase
DXY21_RS18030	COG1793	dna ligase
DXY21_RS18035	COG0726	polysaccharide deacetylase
DXY21_RS18040	COG1846	Transcriptional regulator
DXY21_RS18055	COG0789	Transcriptional regulator
DXY21_RS18060	COG2239	Acts as a magnesium transporter
DXY21_RS18075	COG3858	chitin binding
DXY21_RS18075	COG1388	LysM domain
DXY21_RS18080	COG4721	ABC-type cobalt transport system, permease component
DXY21_RS18085	COG1122	ATPase activity
DXY21_RS18090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY21_RS18095	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY21_RS18100	COG1404	Belongs to the peptidase S8 family
DXY21_RS18110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY21_RS18115	COG2814	Major facilitator Superfamily
DXY21_RS18125	COG0463	Glycosyl transferase, family 2
DXY21_RS18125	COG0457	Tetratricopeptide repeat
DXY21_RS18140	COG1764	response to oxidative stress
DXY21_RS18145	COG1846	Transcriptional regulator
DXY21_RS18150	COG1764	response to oxidative stress
DXY21_RS18160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY21_RS18165	COG0788	formyltetrahydrofolate deformylase activity
DXY21_RS18170	COG2076	Multidrug Resistance protein
DXY21_RS18175	COG2076	Multidrug Resistance protein
DXY21_RS18180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY21_RS18185	COG1607	acyl-coa hydrolase
DXY21_RS18190	COG1834	amidinotransferase
DXY21_RS18195	COG2706	6-phosphogluconolactonase activity
DXY21_RS18200	COG4608	Belongs to the ABC transporter superfamily
DXY21_RS18205	COG0791	NLP P60 protein
DXY21_RS18210	COG4948	Mandelate Racemase Muconate Lactonizing
DXY21_RS18215	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY21_RS18220	COG4166	transmembrane transport
DXY21_RS18225	COG0444	Belongs to the ABC transporter superfamily
DXY21_RS18230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY21_RS18235	COG0601	transmembrane transport
DXY21_RS18240	COG2362	D-Aminopeptidase
DXY21_RS18245	COG0477	Major facilitator Superfamily
DXY21_RS18250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY21_RS18255	COG0463	Glycosyl transferase, family 2
DXY21_RS18260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DXY21_RS18265	COG0346	lactoylglutathione lyase activity
DXY21_RS18270	COG0531	amino acid
DXY21_RS18275	COG1392	Phosphate transport regulator
DXY21_RS18280	COG0306	phosphate transporter
DXY21_RS18295	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS18295	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS18335	COG3778	Protein conserved in bacteria
DXY21_RS18340	COG3299	homolog of phage Mu protein gp47
DXY21_RS18345	COG3628	GPW Gp25 family protein
DXY21_RS18355	COG4193	domain, Protein
DXY21_RS18360	COG1652	LysM domain
DXY21_RS18365	COG3953	SLT domain
DXY21_RS18365	COG3953	SLT domain
DXY21_RS18365	COG5412	phage tail tape measure protein
DXY21_RS18365	COG5412	phage tail tape measure protein
DXY21_RS18365	COG5412	phage tail tape measure protein
DXY21_RS18365	COG3953	SLT domain
DXY21_RS18415	COG4653	Phage capsid family
DXY21_RS18420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DXY21_RS18425	COG5518	Phage portal protein
DXY21_RS18430	COG1783	phage Terminase large subunit
DXY21_RS18435	COG3728	DNA packaging
DXY21_RS18435	COG5484	DNA packaging
DXY21_RS18440	COG1595	DNA-templated transcription, initiation
DXY21_RS18455	COG1484	DNA-dependent DNA replication
DXY21_RS18460	COG1522	sequence-specific DNA binding
DXY21_RS18470	COG1396	sequence-specific DNA binding
DXY21_RS18475	COG2856	Zn peptidase
DXY21_RS18480	COG4195	phage-related replication protein
DXY21_RS18490	COG1388	LysM domain
DXY21_RS18490	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS18490	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS18500	COG0457	Tetratricopeptide repeat
DXY21_RS18505	COG2318	DinB family
DXY21_RS18510	COG0730	response to heat
DXY21_RS18535	COG2197	response regulator
DXY21_RS18540	COG4585	Histidine kinase
DXY21_RS18560	COG2770	Histidine kinase
DXY21_RS18560	COG2205	protein histidine kinase activity
DXY21_RS18565	COG0745	RESPONSE REGULATOR receiver
DXY21_RS18570	COG2721	sulfolactate sulfo-lyase activity
DXY21_RS18575	COG0246	Mannitol dehydrogenase
DXY21_RS18580	COG1609	Transcriptional regulator
DXY21_RS18585	COG2211	Major facilitator Superfamily
DXY21_RS18595	COG1252	NADH dehydrogenase
DXY21_RS18605	COG4297	protein containing double-stranded beta helix domain
DXY21_RS18610	COG0697	spore germination
DXY21_RS18615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY21_RS18620	COG0390	transport system, permease component
DXY21_RS18625	COG1587	Uroporphyrinogen-III synthase
DXY21_RS18635	COG1819	glycosyl
DXY21_RS18640	COG2124	cytochrome p450
DXY21_RS18645	COG2427	Protein of unknown function (DUF1641)
DXY21_RS18650	COG3383	formate dehydrogenase (NAD+) activity
DXY21_RS18660	COG2205	protein histidine kinase activity
DXY21_RS18675	COG1285	pathogenesis
DXY21_RS18690	COG1349	DNA-binding transcription factor activity
DXY21_RS18700	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY21_RS18705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS18705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY21_RS18710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DXY21_RS18715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DXY21_RS18720	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DXY21_RS18730	COG1846	Transcriptional regulator
DXY21_RS18735	COG0477	Major facilitator Superfamily
DXY21_RS18740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY21_RS18745	COG2367	Beta-lactamase
DXY21_RS18750	COG0346	lactoylglutathione lyase activity
DXY21_RS18760	COG5444	nuclease activity
DXY21_RS18800	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY21_RS18800	COG3409	Peptidoglycan-binding domain 1 protein
DXY21_RS18800	COG1388	LysM domain
DXY21_RS18825	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS18835	COG1705	Flagellar rod assembly protein muramidase FlgJ
DXY21_RS18915	COG0582	viral genome integration into host DNA
DXY21_RS18940	COG1216	Glycosyl transferase, family 2
DXY21_RS18950	COG4195	phage-related replication protein
DXY21_RS18955	COG3420	alginic acid biosynthetic process
DXY21_RS18955	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY21_RS19020	COG1388	LysM domain
DXY21_RS19020	COG3584	3D domain protein
DXY21_RS19025	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DXY21_RS19040	COG0756	dUTP diphosphatase activity
DXY21_RS19050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY21_RS19075	COG1780	Probably involved in ribonucleotide reductase function
DXY21_RS19115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY21_RS19115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY21_RS19160	COG3655	Transcriptional regulator
DXY21_RS19185	COG1484	DNA-dependent DNA replication
DXY21_RS19230	COG0626	cystathionine gamma-synthase activity
DXY21_RS19235	COG0626	cystathionine gamma-synthase activity
DXY21_RS19240	COG2382	esterase
DXY21_RS19250	COG2153	protein acetylation
DXY21_RS19260	COG1131	(ABC) transporter
DXY21_RS19280	COG0210	DNA helicase
DXY21_RS19335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DXY21_RS19340	COG0351	phosphomethylpyrimidine kinase
DXY21_RS19345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY21_RS19355	COG2104	thiamine diphosphate biosynthetic process
DXY21_RS19360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY21_RS19365	COG0352	thiamine-phosphate diphosphorylase activity
DXY21_RS19370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DXY21_RS19375	COG0569	domain protein
DXY21_RS19375	COG0475	glutathione-regulated potassium exporter activity
DXY21_RS19385	COG0564	pseudouridine synthase activity
DXY21_RS19390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY21_RS19395	COG2357	RelA SpoT domain protein
DXY21_RS19405	COG4116	CYTH
DXY21_RS19410	COG0741	lytic transglycosylase activity
DXY21_RS19415	COG2346	COG2346, Truncated hemoglobins
DXY21_RS19425	COG1164	Oligoendopeptidase f
DXY21_RS19430	COG4469	Competence protein
DXY21_RS19435	COG4862	establishment of competence for transformation
DXY21_RS19440	COG0861	Integral membrane protein TerC family
DXY21_RS19445	COG1393	Belongs to the ArsC family
DXY21_RS19450	COG0456	acetyltransferase
DXY21_RS19460	COG4608	Belongs to the ABC transporter superfamily
DXY21_RS19465	COG0444	Belongs to the ABC transporter superfamily
DXY21_RS19470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY21_RS19475	COG0601	transmembrane transport
DXY21_RS19480	COG4166	transmembrane transport
DXY21_RS19485	COG0180	Tryptophanyl-tRNA synthetase
DXY21_RS19495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY21_RS19500	COG0601	transmembrane transport
DXY21_RS19510	COG4608	Belongs to the ABC transporter superfamily
DXY21_RS19515	COG0444	Belongs to the ABC transporter superfamily
DXY21_RS19520	COG5504	Zn-dependent protease
DXY21_RS19525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY21_RS19530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY21_RS19545	COG1744	ABC transporter substrate-binding protein PnrA-like
DXY21_RS19555	COG2267	carboxylic ester hydrolase activity
DXY21_RS19570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DXY21_RS19575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY21_RS19580	COG0505	Belongs to the CarA family
DXY21_RS19585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY21_RS19605	COG2271	Major facilitator Superfamily
DXY21_RS19610	COG0277	FAD linked oxidase domain protein
DXY21_RS19620	COG2151	metal-sulfur cluster biosynthetic enzyme
DXY21_RS19625	COG1073	alpha beta
DXY21_RS19630	COG0561	phosphatase activity
DXY21_RS19645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY21_RS19650	COG1307	EDD domain protein, DegV family
DXY21_RS19660	COG0840	transmembrane signaling receptor activity
DXY21_RS19670	COG2996	Protein conserved in bacteria
DXY21_RS19680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DXY21_RS19680	COG0646	methionine synthase
DXY21_RS19685	COG2153	protein acetylation
DXY21_RS19690	COG1357	PFAM Pentapeptide repeats (8 copies)
DXY21_RS19695	COG2318	DinB family
DXY21_RS19700	COG0673	inositol 2-dehydrogenase activity
DXY21_RS19705	COG1609	Transcriptional regulator
DXY21_RS19710	COG2207	Transcriptional regulator
DXY21_RS19710	COG1917	Cupin 2, conserved barrel domain protein
DXY21_RS19715	COG0534	Mate efflux family protein
DXY21_RS19720	COG1562	ergosterol biosynthetic process
DXY21_RS19725	COG0367	asparagine synthase
DXY21_RS19745	COG0179	Fumarylacetoacetate (FAA) hydrolase
DXY21_RS19785	COG1403	HNH endonuclease
DXY21_RS19790	COG0419	ATPase involved in DNA repair
DXY21_RS19795	COG0420	3'-5' exonuclease activity
DXY21_RS19810	COG2323	membrane
DXY21_RS19815	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DXY21_RS19825	COG2814	Major facilitator Superfamily
DXY21_RS19830	COG3180	Ammonia monooxygenase
DXY21_RS19835	COG1846	Transcriptional regulator
DXY21_RS19845	COG0681	Belongs to the peptidase S26 family
DXY21_RS19850	COG0398	Pfam SNARE associated Golgi protein
DXY21_RS19865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY21_RS19885	COG5646	InterPro IPR014922
DXY21_RS19895	COG4903	ComK protein
DXY21_RS19905	COG1028	Short-chain dehydrogenase reductase Sdr
DXY21_RS19910	COG0723	plastoquinol--plastocyanin reductase activity
DXY21_RS19910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY21_RS19915	COG0840	transmembrane signaling receptor activity
DXY21_RS19920	COG1268	BioY protein
DXY21_RS19925	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS19930	COG0183	Belongs to the thiolase family
DXY21_RS19935	COG0406	alpha-ribazole phosphatase activity
DXY21_RS19940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DXY21_RS19950	COG1404	Belongs to the peptidase S8 family
DXY21_RS19955	COG0501	Belongs to the peptidase M48B family
DXY21_RS19965	COG0318	PFAM AMP-dependent synthetase and ligase
DXY21_RS19970	COG0702	epimerase
DXY21_RS19975	COG0095	Lipoate-protein ligase
DXY21_RS19980	COG1234	tRNA 3'-trailer cleavage
DXY21_RS19990	COG1301	dicarboxylic acid transport
DXY21_RS19995	COG1363	Peptidase, m42
DXY21_RS20005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY21_RS20010	COG1511	domain protein
DXY21_RS20015	COG1309	transcriptional regulator
DXY21_RS20035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY21_RS20040	COG2329	Antibiotic biosynthesis monooxygenase
DXY21_RS20045	COG3069	C4-dicarboxylate transmembrane transporter activity
DXY21_RS20050	COG1473	amidohydrolase
DXY21_RS20060	COG4473	ABC transporter
DXY21_RS20065	COG1131	(ABC) transporter
DXY21_RS20070	COG0537	adenosine 5'-monophosphoramidase activity
DXY21_RS20075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DXY21_RS20090	COG4980	gas vesicle protein
DXY21_RS20125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY21_RS20140	COG4717	serine-type aminopeptidase activity
DXY21_RS20145	COG0420	3'-5' exonuclease activity
DXY21_RS20150	COG1668	transmembrane transport
DXY21_RS20155	COG4152	abc transporter atp-binding protein
DXY21_RS20165	COG1024	Enoyl-CoA hydratase
DXY21_RS20175	COG0490	domain, Protein
DXY21_RS20180	COG0475	glutathione-regulated potassium exporter activity
DXY21_RS20190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY21_RS20195	COG0561	phosphatase activity
DXY21_RS20200	COG4335	DNA alkylation repair
DXY21_RS20215	COG0189	ligase activity
DXY21_RS20220	COG0189	ligase activity
DXY21_RS20235	COG0702	epimerase
DXY21_RS20240	COG1132	(ABC) transporter
DXY21_RS20245	COG1132	(ABC) transporter
DXY21_RS20250	COG0589	response to stress
DXY21_RS20260	COG3226	Transcriptional regulator
DXY21_RS20265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY21_RS20270	COG0726	polysaccharide deacetylase
DXY21_RS20275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DXY21_RS20280	COG0668	transmembrane transport
DXY21_RS20290	COG0584	glycerophosphoryl diester phosphodiesterase
DXY21_RS20295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY21_RS20300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY21_RS20305	COG1253	flavin adenine dinucleotide binding
DXY21_RS20310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY21_RS20315	COG0436	Aminotransferase
DXY21_RS20320	COG0789	Transcriptional regulator
DXY21_RS20325	COG1253	flavin adenine dinucleotide binding
DXY21_RS20330	COG0204	Acyl-transferase
DXY21_RS20335	COG1595	DNA-templated transcription, initiation