locus-tag class description C7M19_RS00005 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS00010 ENOG4107SQU synthase C7M19_RS00020 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS00030 ENOG4106A3M Cytochrome p-450 C7M19_RS00035 ENOG4105WFK nuclease C7M19_RS00040 ENOG4105XPP Protein of unknown function (DUF1275) C7M19_RS00050 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M19_RS00060 ENOG4105K7W phage-related replication protein C7M19_RS00065 ENOG4108X3M OsmC Ohr family protein C7M19_RS00090 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C7M19_RS00115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M19_RS00120 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M19_RS00125 ENOG4105U6W MutT NUDIX family protein C7M19_RS00130 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M19_RS00140 ENOG4106F1P AAA ATPase, central domain protein C7M19_RS00145 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C7M19_RS00150 ENOG4105CXI aluminum resistance protein C7M19_RS00155 ENOG4105KV4 Transcriptional regulator C7M19_RS00160 ENOG4105C5F glutamine synthetase C7M19_RS00190 ENOG410780I phosphoprotein phosphatase activity C7M19_RS00195 ENOG410780I phosphoprotein phosphatase activity C7M19_RS00205 ENOG4105CT4 transporter C7M19_RS00210 ENOG4105DSG hydrolase family 43 C7M19_RS00220 ENOG4105C93 Xylose Isomerase C7M19_RS00225 ENOG4105CMG Carbohydrate kinase C7M19_RS00230 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C7M19_RS00250 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M19_RS00265 ENOG4105DQ4 alcohol dehydrogenase C7M19_RS00290 ENOG4105EPI acetyltransferase, (GNAT) family C7M19_RS00320 ENOG4108M1A Chitin-binding protein C7M19_RS00340 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M19_RS00345 ENOG4105K7W phage-related replication protein C7M19_RS00365 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C7M19_RS00375 ENOG4108SVB resolvase C7M19_RS00380 ENOG4105VPS UPF0291 protein C7M19_RS00385 ENOG4105CV1 Transketolase (EC 2.2.1.1) C7M19_RS00395 ENOG4105VXM UPF0154 protein C7M19_RS00405 ENOG4107QIV Cytochrome c biogenesis protein C7M19_RS00440 ENOG4108I0Z Aconitate hydratase C7M19_RS00445 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M19_RS00460 ENOG41067CD Small, acid-soluble spore protein Tlp C7M19_RS00470 ENOG4105MI2 C7M19_RS00475 ENOG4105W8X HesB YadR YfhF-family protein C7M19_RS00480 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C7M19_RS00485 ENOG4105K4P CoA-binding domain protein C7M19_RS00490 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M19_RS00515 ENOG4105CPQ Dehydrogenase C7M19_RS00520 ENOG4108UHU Aldolase C7M19_RS00525 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C7M19_RS00530 ENOG4105DMW Dehydrogenase reductase C7M19_RS00540 ENOG4108I5G Major Facilitator superfamily C7M19_RS00565 ENOG4107R39 (ABC) transporter C7M19_RS00600 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M19_RS00610 ENOG4107SYN Glycosyl hydrolases family 43 C7M19_RS00635 ENOG4105DTD Dehydrogenase C7M19_RS00640 ENOG4108IIH CoA-transferase subunit B C7M19_RS00645 ENOG4105D6N CoA-transferase, subunit a C7M19_RS00650 ENOG4105CY2 Citrate transporter C7M19_RS00655 ENOG4106A3M Cytochrome p-450 C7M19_RS00660 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C7M19_RS00665 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C7M19_RS00670 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M19_RS00675 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M19_RS00680 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) C7M19_RS00690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M19_RS00695 ENOG4107T5V SNARE associated Golgi C7M19_RS00700 ENOG4107QX3 carboxylase C7M19_RS00705 ENOG4105E39 Enoyl-CoA hydratase C7M19_RS00710 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C7M19_RS00715 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C7M19_RS00720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M19_RS00725 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS00730 ENOG4105C1G acyl-Coa dehydrogenase C7M19_RS00735 ENOG4105F32 YngK protein C7M19_RS00740 ENOG4106U2H Protein of unknown function (DUF1360) C7M19_RS00750 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS00755 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS00765 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS00770 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C7M19_RS00775 ENOG4108N2V aldose 1-epimerase C7M19_RS00780 ENOG4107QJQ Mate efflux family protein C7M19_RS00805 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M19_RS00825 ENOG41068G1 C7M19_RS00835 ENOG4107X35 defense response to bacterium C7M19_RS00910 ENOG4105CAR Terminase, large subunit C7M19_RS00950 ENOG410682Q Phage transcriptional regulator, ArpU C7M19_RS01045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M19_RS01065 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M19_RS01070 ENOG4108RWP Major Facilitator Superfamily protein C7M19_RS01075 ENOG4105WAB arsR family transcriptional regulator C7M19_RS01080 ENOG4105C22 threonyL-tRNA synthetase C7M19_RS01085 ENOG4108KSA LysR family transcriptional regulator C7M19_RS01090 ENOG4105CB2 alcohol dehydrogenase C7M19_RS01095 ENOG4105BZ8 glutamate synthase C7M19_RS01100 ENOG4105CBC glutamate synthase C7M19_RS01105 ENOG4105C5Q Transcriptional regulator C7M19_RS01110 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M19_RS01140 ENOG4108UB7 C7M19_RS01145 ENOG4105IE8 Alpha-ketoglutarate permease C7M19_RS01150 ENOG4107U6E carbohydrate kinase FGGY C7M19_RS01155 ENOG4108M3J Dehydrogenase C7M19_RS01160 ENOG4108J2R molybdopterin oxidoreductase C7M19_RS01185 ENOG4106ANW SMI1_KNR4 C7M19_RS01190 ENOG4106BHF C7M19_RS01195 ENOG4108Z7R Chaperone CsaA C7M19_RS01200 ENOG4105FTV AraC Family Transcriptional Regulator C7M19_RS01210 ENOG4108W8B Beta-lactamase domain protein C7M19_RS01220 ENOG4105KTU Transcriptional regulator, arsr family C7M19_RS01230 ENOG4108SJC Membrane C7M19_RS01255 ENOG41069ER domain protein C7M19_RS01260 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M19_RS01270 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M19_RS01275 ENOG4105SCY DNAK suppressor C7M19_RS01320 ENOG4105C26 Dehydrogenase C7M19_RS01325 ENOG4105EWU Squalene--hopene cyclase C7M19_RS01330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M19_RS01335 ENOG4105C8J )-transporter C7M19_RS01340 ENOG4105C09 Bile acid C7M19_RS01350 ENOG4105C7S Dehydrogenase C7M19_RS01355 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C7M19_RS01360 ENOG4107T89 von Willebrand factor, type A C7M19_RS01365 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C7M19_RS01375 ENOG4105K4H Nlp p60 protein C7M19_RS01380 ENOG41087PP glycosyltransferase MGT family C7M19_RS01390 ENOG4107QMU Mate efflux family protein C7M19_RS01395 ENOG4106SCS STAS domain C7M19_RS01415 ENOG4105FR1 rard protein C7M19_RS01430 ENOG41090U3 tautomerase C7M19_RS01450 ENOG4105FBA Phospholipase Carboxylesterase C7M19_RS01465 ENOG4105E1V na solute symporter C7M19_RS01475 ENOG4105CS2 ec 3.2.1.21 C7M19_RS01480 ENOG4108S3Y transcriptional regulator C7M19_RS01500 ENOG4108VXD carboxy-peptidase C7M19_RS01505 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C7M19_RS01515 ENOG4106Z5R C7M19_RS01520 ENOG410841Q phosphoesterase PA-phosphatase related protein C7M19_RS01545 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C7M19_RS01550 ENOG4108TSC N-acetyltransferase C7M19_RS01555 ENOG4107S4Y M20 DapE family protein YgeY C7M19_RS01570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M19_RS01575 ENOG4105FTQ Dna gyrase C7M19_RS01655 ENOG4105C26 Dehydrogenase C7M19_RS01665 ENOG4106ANW SMI1_KNR4 C7M19_RS01710 ENOG4107NTZ C7M19_RS01735 ENOG410780I phosphoprotein phosphatase activity C7M19_RS01785 ENOG41090AA C7M19_RS01790 ENOG4106BHF C7M19_RS01800 ENOG4107Y9E nuclease C7M19_RS01815 ENOG4105E0X reductase C7M19_RS01820 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C7M19_RS01830 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C7M19_RS01835 ENOG41090WU lipolytic protein G-D-S-L family C7M19_RS01840 ENOG4108KF3 Electron transport protein SCO1 SenC C7M19_RS01850 ENOG4105C7B Threonine dehydratase C7M19_RS01860 ENOG4108UT2 hemolysin iii C7M19_RS01870 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M19_RS01875 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C7M19_RS01885 ENOG4107YX5 Pfam:DUF548 C7M19_RS01890 ENOG4108Y6J UPF0403 protein C7M19_RS01895 ENOG4105C01 Dihydroxy-acid dehydratase C7M19_RS01910 ENOG4108V06 Glutathione peroxidase C7M19_RS01915 ENOG4105CVG Homoserine O-transsuccinylase C7M19_RS01960 ENOG41081VK Ribonuclease C7M19_RS01985 ENOG410890F Dynamin family C7M19_RS02000 ENOG41065KQ synthase C7M19_RS02020 ENOG410900G Protein of unknown function (DUF421) C7M19_RS02035 ENOG4105C2W permease C7M19_RS02040 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C7M19_RS02045 ENOG4105CTD carboxy-peptidase C7M19_RS02050 ENOG4105DVT helicase C7M19_RS02065 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C7M19_RS02075 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) C7M19_RS02080 ENOG4108UKS UPF0398 protein C7M19_RS02095 ENOG4107X2U Inherit from COG: Exonuclease-like protein C7M19_RS02100 ENOG4108I5C dEAD DEAH box helicase C7M19_RS02145 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C7M19_RS02150 ENOG4105BZ4 penicillin-binding protein C7M19_RS02160 ENOG4105CSM endonuclease III C7M19_RS02170 ENOG4105C5S asparaginyl-tRNA synthetase C7M19_RS02175 ENOG4105CHM Aminotransferase C7M19_RS02185 ENOG4105YAC C7M19_RS02190 ENOG4105DVT helicase C7M19_RS02195 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C7M19_RS02205 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C7M19_RS02215 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C7M19_RS02220 ENOG4105CPK Glycosyl transferase (Group 1 C7M19_RS02225 ENOG4105FJR Lmbe family C7M19_RS02230 ENOG4108Z5K methylglyoxal synthase C7M19_RS02235 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C7M19_RS02240 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C7M19_RS02245 ENOG4108JYZ YitT family C7M19_RS02250 ENOG4105F0F Oxalate decarboxylase C7M19_RS02270 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C7M19_RS02290 ENOG41068YB TPR repeat-containing protein C7M19_RS02300 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C7M19_RS02310 ENOG4105CIH Imidazole acetol-phosphate transaminase C7M19_RS02320 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C7M19_RS02325 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C7M19_RS02330 ENOG4105DK0 Indole-3-glycerol phosphate synthase C7M19_RS02340 ENOG4105CRQ synthase (Component I) C7M19_RS02345 ENOG4105KHN chorismate mutase C7M19_RS02355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C7M19_RS02360 ENOG4105BZU Histidine kinase C7M19_RS02365 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C7M19_RS02370 ENOG4105EAH synthase C7M19_RS02375 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C7M19_RS02380 ENOG4105XXQ heptaprenyl diphosphate synthase component I C7M19_RS02385 ENOG4105WP2 Tryptophan RNA-binding attenuator protein C7M19_RS02390 ENOG4105EUJ GTP cyclohydrolase i C7M19_RS02395 ENOG4105K70 DNA-binding protein C7M19_RS02400 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C7M19_RS02415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C7M19_RS02420 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C7M19_RS02440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C7M19_RS02445 ENOG4105CAT Cytidine monophosphate kinase C7M19_RS02460 ENOG4105MSI germination protein ypeb C7M19_RS02470 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C7M19_RS02475 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C7M19_RS02490 ENOG4107RGJ metallophosphoesterase C7M19_RS02505 ENOG4105I7S Abortive infection protein C7M19_RS02510 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M19_RS02515 ENOG4105T7X C7M19_RS02525 ENOG4108SAX Membrane C7M19_RS02530 ENOG4108JQ1 Dehydrogenase C7M19_RS02545 ENOG4105BZU Histidine kinase C7M19_RS02550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS02555 ENOG4105CRE cytochrome C C7M19_RS02560 ENOG4107TWT Cytochrome c biogenesis protein C7M19_RS02570 ENOG4105FE9 pseudouridine synthase C7M19_RS02580 ENOG4108JIC nucleoside recognition domain protein C7M19_RS02585 ENOG4105DZ1 carboxypeptidase C7M19_RS02595 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C7M19_RS02600 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C7M19_RS02620 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C7M19_RS02625 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C7M19_RS02630 ENOG4108R6K riboflavin synthase, subunit alpha C7M19_RS02655 ENOG4107ZE5 PPIases accelerate the folding of proteins C7M19_RS02660 ENOG4105PTM secreted protein C7M19_RS02665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C7M19_RS02675 ENOG4105G6R Stage v sporulation protein ae C7M19_RS02685 ENOG4105CZ3 stage V sporulation protein ad C7M19_RS02690 ENOG41090VF Stage v sporulation protein ac C7M19_RS02705 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS02710 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M19_RS02715 ENOG41082AN stage II sporulation protein C7M19_RS02720 ENOG4105DZ1 carboxypeptidase C7M19_RS02725 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C7M19_RS02730 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C7M19_RS02735 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M19_RS02745 ENOG4105I3K Ferric uptake regulator, Fur family C7M19_RS02750 ENOG4105MZ9 stage II sporulation protein m C7M19_RS02770 ENOG4105DFD Na H antiporter C7M19_RS02775 ENOG4108IJ0 Aspartate ammonia-lyase C7M19_RS02780 ENOG4105HDK L-asparaginase C7M19_RS02785 ENOG4108IMY Transcriptional regulator C7M19_RS02795 ENOG4108YZ4 nudix hydrolase C7M19_RS02805 ENOG4105CPC Aldo Keto reductase C7M19_RS02825 ENOG4106HZJ C7M19_RS02830 ENOG4105RHY Pfam:UPF0157 C7M19_RS02835 ENOG4105KAC Antibiotic biosynthesis monooxygenase C7M19_RS02840 ENOG4108XET gCN5-related N-acetyltransferase C7M19_RS02845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M19_RS02860 ENOG4105C02 permease C7M19_RS02870 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C7M19_RS02875 ENOG4105CS9 pantothenic acid kinase C7M19_RS02885 ENOG4108IXY short-chain dehydrogenase reductase C7M19_RS02890 ENOG41069FQ Metallo-beta-lactamase superfamily C7M19_RS02895 ENOG4105II7 pyrroline-5-carboxylate reductase C7M19_RS02900 ENOG4108KQ6 Enoyl-CoA hydratase C7M19_RS02905 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C7M19_RS02910 ENOG4106A3M Cytochrome p-450 C7M19_RS02925 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS02930 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS02940 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS02950 ENOG4105CHR reductase C7M19_RS02955 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS02970 ENOG4107QKG PfaD family C7M19_RS02975 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C7M19_RS02980 ENOG4108K70 Transcriptional regulator C7M19_RS02990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M19_RS03000 ENOG410861F 50S ribosomal protein L33 C7M19_RS03005 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C7M19_RS03010 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C7M19_RS03015 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M19_RS03020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M19_RS03030 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C7M19_RS03035 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M19_RS03040 ENOG4108HNZ carboxyl transferase C7M19_RS03045 ENOG4108ZVT methylmalonyl-coA epimerase C7M19_RS03055 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C7M19_RS03060 ENOG4108QEG Membrane C7M19_RS03065 ENOG4105CDA abc transporter atp-binding protein C7M19_RS03070 ENOG4105E5Q amino acid AbC transporter C7M19_RS03075 ENOG4108HW3 (ABC) transporter C7M19_RS03080 ENOG4108Y6J UPF0403 protein C7M19_RS03085 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C7M19_RS03090 ENOG4105C7S Dehydrogenase C7M19_RS03095 ENOG4105CPP Dehydrogenase, E1 component C7M19_RS03110 ENOG4105CKM Branched-chain carboxylic acid kinase C7M19_RS03115 ENOG4107RDP Dehydrogenase C7M19_RS03125 ENOG4108JUB Transcriptional regulator C7M19_RS03130 ENOG4106CCJ Protein of unknown function (DUF2627) C7M19_RS03135 ENOG4105CR4 methylisocitrate lyase C7M19_RS03140 ENOG4105DXD 2-methylcitrate dehydratase C7M19_RS03150 ENOG4105C1G acyl-Coa dehydrogenase C7M19_RS03155 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C7M19_RS03165 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M19_RS03170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M19_RS03190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M19_RS03205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M19_RS03210 ENOG4107QQR Sporulation C7M19_RS03215 ENOG4105S1Z Stage IV sporulation protein B C7M19_RS03220 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C7M19_RS03225 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C7M19_RS03230 ENOG4105DX0 Hemolysin A C7M19_RS03235 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C7M19_RS03240 ENOG4105CTB Polyprenyl synthetase C7M19_RS03245 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M19_RS03250 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M19_RS03255 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C7M19_RS03260 ENOG4105M7K Involved in the transcription termination process (By similarity) C7M19_RS03265 ENOG4108ZSR alkaline shock protein C7M19_RS03270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M19_RS03290 ENOG410644B Stage III sporulation protein af C7M19_RS03300 ENOG4105KQ4 Stage iii sporulation protein ad C7M19_RS03305 ENOG4108CQH stage III sporulation protein AC C7M19_RS03310 ENOG4105KR5 Stage iii sporulation protein C7M19_RS03315 ENOG4105CD2 stage iii sporulation protein aa C7M19_RS03325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C7M19_RS03330 ENOG4105DC7 peptidase M24 C7M19_RS03340 ENOG4105CBJ Metal-dependent enzyme C7M19_RS03360 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C7M19_RS03365 ENOG4105WZW rhodanese family C7M19_RS03370 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M19_RS03380 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C7M19_RS03385 ENOG4105C0D helicase C7M19_RS03400 ENOG4108IMY Transcriptional regulator C7M19_RS03410 ENOG4105VFR signal peptidase C7M19_RS03470 ENOG4105C37 (CBS) domain C7M19_RS03495 ENOG4105C5X domain protein C7M19_RS03540 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C7M19_RS03545 ENOG4105WDJ 50S ribosomal protein L33 C7M19_RS03555 ENOG41068DG YceG-like family C7M19_RS03560 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M19_RS03565 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M19_RS03570 ENOG4105E2Z phosphate ABC transporter (Permease C7M19_RS03575 ENOG4105C8U phosphate abc transporter C7M19_RS03580 ENOG4105CVA phosphate C7M19_RS03585 ENOG4107RF6 penicillin-binding protein C7M19_RS03595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M19_RS03600 ENOG4105SXS Protein of unknown function (DUF456) C7M19_RS03615 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C7M19_RS03620 ENOG41063Y9 C7M19_RS03625 ENOG4108U5J '-nucleotidase C7M19_RS03630 ENOG4105N80 Ferric uptake regulator, Fur family C7M19_RS03635 ENOG4108JYZ YitT family C7M19_RS03640 ENOG41069ZM Protein of unknown function (DUF2624) C7M19_RS03645 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C7M19_RS03660 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C7M19_RS03665 ENOG4105EGD dinuclear metal center protein, YbgI family C7M19_RS03680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS03685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C7M19_RS03690 ENOG4108UPT UPF0178 protein C7M19_RS03695 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C7M19_RS03705 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C7M19_RS03710 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C7M19_RS03715 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C7M19_RS03725 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C7M19_RS03730 ENOG4105KG3 cytidine deaminase C7M19_RS03735 ENOG4107YR5 Diacylglycerol kinase C7M19_RS03740 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C7M19_RS03745 ENOG4105CTJ Metal Dependent Phosphohydrolase C7M19_RS03750 ENOG4105C9A Phoh family C7M19_RS03755 ENOG4105EI1 sporulation protein yqfd C7M19_RS03760 ENOG41068P3 sporulation protein YqfC C7M19_RS03770 ENOG4105DI5 UPF0365 protein C7M19_RS03775 ENOG4105F7J membrane-bound serine protease C7M19_RS03780 ENOG4105KTH gatB Yqey C7M19_RS03795 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M19_RS03800 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C7M19_RS03805 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C7M19_RS03810 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C7M19_RS03815 ENOG4105CFG Acts as a chaperone (By similarity) C7M19_RS03820 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C7M19_RS03825 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C7M19_RS03830 ENOG4105CSA Coproporphyrinogen iii oxidase C7M19_RS03835 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C7M19_RS03845 ENOG4108ZRV stage ii sporulation protein p C7M19_RS03850 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C7M19_RS03855 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C7M19_RS03860 ENOG4105TQK DNA polymerase iii, delta' subunit C7M19_RS03875 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C7M19_RS03880 ENOG4108UK2 deaminase C7M19_RS03885 ENOG4105KQC Competence protein C7M19_RS03895 ENOG4108D32 Methyltransferase C7M19_RS03905 ENOG4108WF2 Metal Dependent Phosphohydrolase C7M19_RS03910 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C7M19_RS03915 ENOG410812S Rna-binding protein C7M19_RS03920 ENOG4105E2X shikimate dehydrogenase C7M19_RS03925 ENOG4105CQW ribosome biogenesis GTPase YqeH C7M19_RS03930 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C7M19_RS03950 ENOG41080BT SNARE associated Golgi C7M19_RS03965 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS03980 ENOG41086D8 Transcriptional regulator C7M19_RS03990 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C7M19_RS04035 ENOG4108U7W acetyltransferase C7M19_RS04050 ENOG4105DQF Hydrolase C7M19_RS04065 ENOG4105DG6 mannose-6-phosphate isomerase C7M19_RS04070 ENOG4105DM4 PTS System C7M19_RS04085 ENOG4108Z66 YbaK ebsC protein C7M19_RS04090 ENOG4107RSM transcriptional regulator C7M19_RS04095 ENOG4105D94 Major Facilitator Superfamily C7M19_RS04100 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M19_RS04105 ENOG41082JN Transcriptional regulator C7M19_RS04120 ENOG4105TMB Formate nitrite transporter C7M19_RS04125 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C7M19_RS04130 ENOG4108JB9 formate dehydrogenase C7M19_RS04145 ENOG4105C28 cystathionine C7M19_RS04175 ENOG4107XRG penicillin-binding protein C7M19_RS04180 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C7M19_RS04190 ENOG4105CFP Peptidase U32 C7M19_RS04195 ENOG4105XYU peptidase (U32 family) C7M19_RS04200 ENOG4108VQJ O-methyltransferase C7M19_RS04205 ENOG4105HHA aminodeoxychorismate lyase C7M19_RS04215 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C7M19_RS04220 ENOG4105VBH UPF0297 protein C7M19_RS04225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C7M19_RS04230 ENOG4105C02 permease C7M19_RS04235 ENOG4105CDA abc transporter atp-binding protein C7M19_RS04240 ENOG4105CT1 (ABC) transporter C7M19_RS04245 ENOG4105EAD ABC transporter C7M19_RS04250 ENOG4105DRP amino acid AbC transporter C7M19_RS04260 ENOG41060CR C7M19_RS04270 ENOG4105C7H Helicase, RecD TraA family C7M19_RS04280 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C7M19_RS04285 ENOG4105C3J Cysteine desulfurase C7M19_RS04295 ENOG4105D1H recombination factor protein RarA C7M19_RS04300 ENOG4105CUZ uba thif-type nad fad binding protein C7M19_RS04310 ENOG4105C9M aspartyl-trna synthetase C7M19_RS04315 ENOG4105CUT histidyl-tRNA synthetase C7M19_RS04325 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M19_RS04330 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C7M19_RS04335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C7M19_RS04345 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C7M19_RS04350 ENOG41067VP Protein of unknown function (DUF1049) C7M19_RS04355 ENOG4105NCW Trka-c domain protein C7M19_RS04360 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C7M19_RS04370 ENOG4105CKP Polysaccharide Biosynthesis Protein C7M19_RS04375 ENOG4108QG2 Membrane C7M19_RS04380 ENOG4105NAP C7M19_RS04385 ENOG4105VIE preprotein translocase, subunit YajC C7M19_RS04390 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C7M19_RS04395 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C7M19_RS04400 ENOG41061AI Protein of unknown function (DUF2905) C7M19_RS04405 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C7M19_RS04410 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C7M19_RS04430 ENOG4106678 morphogenetic protein associated with SpoVID C7M19_RS04435 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C7M19_RS04440 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C7M19_RS04445 ENOG4108IYU L-aspartate oxidase C7M19_RS04460 ENOG4105CQC Prephenate dehydratase C7M19_RS04470 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C7M19_RS04480 ENOG4105K46 50S ribosomal protein l27 C7M19_RS04485 ENOG4105X36 (ribosomal) protein C7M19_RS04490 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C7M19_RS04505 ENOG4107QMS site-determining protein C7M19_RS04510 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C7M19_RS04515 ENOG4105YHC Rod shape-determining protein MreD C7M19_RS04520 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C7M19_RS04525 ENOG4105DFF Rod shape-determining protein mreb C7M19_RS04530 ENOG4105W5Q DNA repair protein (RadC C7M19_RS04535 ENOG4108Z03 MAF-like protein C7M19_RS04545 ENOG4106A3R peptidase C7M19_RS04550 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C7M19_RS04555 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C7M19_RS04565 ENOG4106AR7 Spore coat protein C7M19_RS04570 ENOG41068KH stage VI sporulation protein D C7M19_RS04575 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C7M19_RS04580 ENOG4105D52 delta-aminolevulinic acid dehydratase C7M19_RS04590 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C7M19_RS04600 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C7M19_RS04610 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C7M19_RS04615 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C7M19_RS04620 ENOG4108IUQ atp-dependent protease C7M19_RS04625 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C7M19_RS04630 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C7M19_RS04640 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M19_RS04645 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M19_RS04650 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M19_RS04660 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C7M19_RS04665 ENOG4108ZP8 Acetolactate synthase small subunit C7M19_RS04670 ENOG4105C7K acetolactate synthase C7M19_RS04720 ENOG4105M59 Phosphodiesterase, mj0936 family C7M19_RS04725 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C7M19_RS04730 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C7M19_RS04735 ENOG4108XJQ germination protein C7M19_RS04740 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M19_RS04745 ENOG41067TZ transcriptional regulator, MarR family C7M19_RS04750 ENOG4105PFC Transcriptional regulator C7M19_RS04760 ENOG4105E33 succinate dehydrogenase C7M19_RS04770 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C7M19_RS04780 ENOG4105CFH Aspartokinase C7M19_RS04785 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C7M19_RS04790 ENOG4105K63 Thioredoxin C7M19_RS04795 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M19_RS04800 ENOG4105C10 Electron transfer flavoprotein C7M19_RS04805 ENOG4105BZJ Electron transfer flavoprotein C7M19_RS04810 ENOG41060WC Enoyl-CoA hydratase C7M19_RS04815 ENOG4107Z3H Transcriptional regulator, TetR family C7M19_RS04820 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS04825 ENOG4108YV3 Protein of unknown function (DUF2711) C7M19_RS04835 ENOG4105C98 muts2 protein C7M19_RS04840 ENOG4105DCG PHP domain protein C7M19_RS04855 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M19_RS04865 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C7M19_RS04870 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C7M19_RS04875 ENOG4108RWN rrna methyltransferase C7M19_RS04880 ENOG41067MF small acid-soluble spore protein C7M19_RS04890 ENOG4105CQB FAD linked oxidase domain protein C7M19_RS04895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M19_RS04905 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M19_RS04910 ENOG4105DRS transport system, permease C7M19_RS04925 ENOG4108MDK Dehydrogenase C7M19_RS04935 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C7M19_RS04940 ENOG4105EF1 ribulokinase C7M19_RS04950 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C7M19_RS04955 ENOG4105CN9 Peptidase m42 family protein C7M19_RS04965 ENOG410696E Membrane C7M19_RS04970 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C7M19_RS04975 ENOG4105VJV 50s ribosomal protein L35 C7M19_RS04980 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C7M19_RS04985 ENOG41067MG lrgb family C7M19_RS04995 ENOG4105DY9 regulatoR C7M19_RS05000 ENOG4108HRK Histidine kinase C7M19_RS05005 ENOG4105U0R haloacid dehalogenase-like hydrolase C7M19_RS05010 ENOG4105C22 threonyL-tRNA synthetase C7M19_RS05015 ENOG4108TDW sporulation protein YtxC C7M19_RS05040 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C7M19_RS05045 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M19_RS05050 ENOG4105KVH Transcriptional regulator C7M19_RS05055 ENOG4105F27 Major Facilitator C7M19_RS05060 ENOG4105CV8 reductase C7M19_RS05065 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C7M19_RS05075 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C7M19_RS05080 ENOG4105C2M dna polymerase I C7M19_RS05085 ENOG4105BZU Histidine kinase C7M19_RS05090 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M19_RS05100 ENOG4108HMX isocitrate dehydrogenase (NADP) C7M19_RS05105 ENOG4105BZN citrate synthase C7M19_RS05120 ENOG4105G7B Protein of unknown function (DUF2992) C7M19_RS05125 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M19_RS05135 ENOG4108REF Sporulation integral membrane protein ytvi C7M19_RS05140 ENOG4105FS0 cytoplasmic membrane protein C7M19_RS05145 ENOG4105CA9 Pyruvate kinase C7M19_RS05150 ENOG4105CTQ phosphohexokinase C7M19_RS05155 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C7M19_RS05160 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C7M19_RS05165 ENOG4105C6K Malic enzyme C7M19_RS05170 ENOG4105C0B DNA polymerase III (alpha subunit) C7M19_RS05175 ENOG4105VV2 C7M19_RS05185 ENOG4106EVM C7M19_RS05190 ENOG4105SFS phosphoesterase RecJ domain protein C7M19_RS05205 ENOG4105E8R UPF0173 metal-dependent hydrolase C7M19_RS05215 ENOG4105CH7 arginosuccinase C7M19_RS05220 ENOG4105CDH Citrulline--aspartate ligase C7M19_RS05225 ENOG4105EPU Molybdenum cofactor synthesis domain protein C7M19_RS05230 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C7M19_RS05240 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C7M19_RS05245 ENOG4105KBJ sporulation protein ytfj C7M19_RS05255 ENOG4105VK3 rdd domain containing protein C7M19_RS05260 ENOG4105D07 Signal peptide peptidase, SppA C7M19_RS05265 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M19_RS05270 ENOG4105EFZ amidohydrolase C7M19_RS05275 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C7M19_RS05285 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C7M19_RS05310 ENOG4105U5Y Transcriptional regulator C7M19_RS05320 ENOG4105BZU Histidine kinase C7M19_RS05330 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C7M19_RS05335 ENOG410780I phosphoprotein phosphatase activity C7M19_RS05355 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C7M19_RS05370 ENOG4108Z0Z intracellular protease Pfpi family C7M19_RS05390 ENOG4108NGU Transcriptional regulator C7M19_RS05405 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M19_RS05415 ENOG4105F1V Acetoin utilization protein C7M19_RS05420 ENOG4105W87 Cbs domain C7M19_RS05425 ENOG4105DGU Histone deacetylase C7M19_RS05430 ENOG4105ER2 Ompa motb domain protein C7M19_RS05435 ENOG4107R0U MotA TolQ exbB proton channel C7M19_RS05440 ENOG4105ETE Transcriptional regulator (LacI family C7M19_RS05445 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C7M19_RS05465 ENOG4105DFU Cell wall formation (By similarity) C7M19_RS05475 ENOG4108VDD TRNA binding domain protein C7M19_RS05490 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C7M19_RS05505 ENOG4105C6K Malic enzyme C7M19_RS05510 ENOG4105C8F Beta-lactamase domain protein C7M19_RS05515 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C7M19_RS05525 ENOG4108V15 phosphotransferase enzyme family C7M19_RS05540 ENOG4107F58 2'-5' rna ligase C7M19_RS05545 ENOG4105C6T cysteine synthase C7M19_RS05550 ENOG4107QSE Dipeptidase C7M19_RS05555 ENOG4105C7N Xanthine uracil vitamin C permease C7M19_RS05570 ENOG4105YW5 deoR family transcriptional regulator C7M19_RS05585 ENOG4105CBX hi0933 family C7M19_RS05590 ENOG4105C94 Transporter C7M19_RS05610 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component C7M19_RS05615 ENOG4105I1K ABC transporter C7M19_RS05630 ENOG41085GJ domain protein C7M19_RS05635 ENOG4105C8T Leucyl-tRNA synthetase C7M19_RS05645 ENOG4105BZU Histidine kinase C7M19_RS05650 ENOG410605W Major Facilitator C7M19_RS05665 ENOG4105C19 ABC transporter C7M19_RS05670 ENOG4105EWM Histidine kinase C7M19_RS05680 ENOG4107R34 abc transporter permease protein C7M19_RS05685 ENOG4105C19 ABC transporter C7M19_RS05705 ENOG4105DVE abc transporter atp-binding protein C7M19_RS05710 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS05730 ENOG4105N5T Radical SAM Protein C7M19_RS05745 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C7M19_RS05755 ENOG4105E8V Alpha Beta Hydrolase Fold protein C7M19_RS05760 ENOG4108Z0R Transferase C7M19_RS05765 ENOG4105C85 amino acid C7M19_RS05770 ENOG4105CAQ asparagine synthetase C7M19_RS05775 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C7M19_RS05780 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C7M19_RS05795 ENOG4105D2X ABC transporter substrate-binding protein C7M19_RS05805 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C7M19_RS05820 ENOG4108RMU ferritin dps family protein C7M19_RS05835 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C7M19_RS05840 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C7M19_RS05845 ENOG4108V2W Carbonate dehydratase C7M19_RS05850 ENOG4105NRA 50s ribosomal protein l31 type b C7M19_RS05870 ENOG4105DTQ mandelate racemase muconate lactonizing C7M19_RS05875 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS05880 ENOG4108IPT Naphthoate synthase C7M19_RS05885 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C7M19_RS05890 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C7M19_RS05895 ENOG4105E4F Isochorismate synthase C7M19_RS06030 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C7M19_RS06035 ENOG4105DZ6 Band 7 protein C7M19_RS06045 ENOG4106DF1 C7M19_RS06050 ENOG4108VNY MOSC domain protein C7M19_RS06055 ENOG4108JB8 alcohol dehydrogenase C7M19_RS06060 ENOG4105C26 Dehydrogenase C7M19_RS06065 ENOG4105TRT Transcriptional regulator C7M19_RS06080 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C7M19_RS06085 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C7M19_RS06105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C7M19_RS06115 ENOG4105EE0 oxidoreductase C7M19_RS06120 ENOG4108Z0Z intracellular protease Pfpi family C7M19_RS06125 ENOG4105C8Q Methyl-accepting chemotaxis C7M19_RS06130 ENOG4105C8Q Methyl-accepting chemotaxis C7M19_RS06135 ENOG4105C8Q Methyl-accepting chemotaxis C7M19_RS06140 ENOG4105C8Q Methyl-accepting chemotaxis C7M19_RS06155 ENOG4105EA8 2-Nitropropane dioxygenase C7M19_RS06160 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C7M19_RS06170 ENOG4105C37 (CBS) domain C7M19_RS06185 ENOG4107PBV potassium channel C7M19_RS06190 ENOG4107PBV potassium channel C7M19_RS06205 ENOG4107QYV phosphohexose isomerase C7M19_RS06215 ENOG4105CHJ isochorismatase hydrolase C7M19_RS06225 ENOG4107QW4 alcohol dehydrogenase C7M19_RS06230 ENOG4105WG9 Conserved Protein C7M19_RS06240 ENOG4105CHM Aminotransferase C7M19_RS06245 ENOG4108ZB6 transcriptional regulator AsnC family C7M19_RS06250 ENOG4108MUZ hydrolase C7M19_RS06260 ENOG4105C87 Aminotransferase class I and II C7M19_RS06265 ENOG4108HGU Histidine kinase C7M19_RS06270 ENOG4105Y38 Kinase-associated protein B C7M19_RS06285 ENOG4105BZ4 penicillin-binding protein C7M19_RS06290 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C7M19_RS06305 ENOG4108MRH transcriptional regulatory protein C7M19_RS06310 ENOG4105DIH basic membrane C7M19_RS06315 ENOG4108JQ9 ABC transporter C7M19_RS06320 ENOG4105UIB (ABC) transporter C7M19_RS06335 ENOG4105D65 subunit l C7M19_RS06340 ENOG4105HC0 Na H antiporter C7M19_RS06345 ENOG4108ZE9 Monovalent cation H antiporter subunit C C7M19_RS06350 ENOG4108JPZ Monovalent cation H antiporter subunit D C7M19_RS06355 ENOG4105SC1 monovalent cation H antiporter subunit E C7M19_RS06365 ENOG4105KJM monovalent cation h antiporter subunit g C7M19_RS06370 ENOG4105KA0 thioesterase Superfamily protein C7M19_RS06380 ENOG4105BZU Histidine kinase C7M19_RS06405 ENOG4105D58 Diguanylate phosphodiesterase C7M19_RS06410 ENOG4105DAP Nicotinate phosphoribosyltransferase C7M19_RS06435 ENOG4105C02 permease C7M19_RS06450 ENOG410904N short-chain dehydrogenase reductase C7M19_RS06485 ENOG4108K8K Transcriptional regulator C7M19_RS06490 ENOG4105DCF alanine dehydrogenase C7M19_RS06500 ENOG4105WQT MbtH domain protein C7M19_RS06505 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS06510 ENOG4105WQI isochorismatase C7M19_RS06515 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C7M19_RS06520 ENOG4105E4F Isochorismate synthase C7M19_RS06525 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C7M19_RS06530 ENOG4105NIV Esterase C7M19_RS06550 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C7M19_RS06560 ENOG41069ER domain protein C7M19_RS06575 ENOG4105CEP NADH dehydrogenase C7M19_RS06585 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) C7M19_RS06600 ENOG4105CJ1 ABC, transporter C7M19_RS06625 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C7M19_RS06630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C7M19_RS06635 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C7M19_RS06645 ENOG4105ZKE UPF0349 protein C7M19_RS06660 ENOG41083MR nifu domain-containing protein C7M19_RS06665 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C7M19_RS06670 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C7M19_RS06675 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C7M19_RS06680 ENOG4105D6E homoserine dehydrogenase C7M19_RS06690 ENOG4108W5N phosphatidylglycerophosphatase a C7M19_RS06695 ENOG4105D4U had-superfamily hydrolase, subfamily iia C7M19_RS06705 ENOG4105MMD transcriptional regulator C7M19_RS06710 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C7M19_RS06715 ENOG4105FAA peptidase M23 C7M19_RS06720 ENOG4108YTE sporulation protein YunB C7M19_RS06725 ENOG4107R8B 5'-nucleotidase C7M19_RS06735 ENOG4105I3N Conserved Protein C7M19_RS06745 ENOG4105CD3 dihydroorotase C7M19_RS06750 ENOG4105G9B Transcriptional regulator C7M19_RS06775 ENOG4105C5R Aminotransferase C7M19_RS06785 ENOG4108K8S endonuclease I C7M19_RS06790 ENOG4108IJ9 (ABC) transporter C7M19_RS06795 ENOG4105FDP GntR family transcriptional regulator C7M19_RS06800 ENOG4108KPW sugar kinase C7M19_RS06805 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C7M19_RS06810 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C7M19_RS06815 ENOG4105XN3 extracellular solute-binding protein family 1 C7M19_RS06820 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C7M19_RS06850 ENOG4105PKS Excinuclease abc c subunit domain protein C7M19_RS06855 ENOG4107VFR oxidoreductase C7M19_RS06860 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C7M19_RS06870 ENOG41083Q9 chitosanase C7M19_RS06875 ENOG4105DIW FeS assembly protein SUFB C7M19_RS06880 ENOG4108UNV SUF system FeS assembly protein, NifU family C7M19_RS06885 ENOG4105C9B Cysteine desulfurase C7M19_RS06890 ENOG4105JRK feS assembly protein SufD C7M19_RS06895 ENOG4105C3K feS assembly ATPase SufC C7M19_RS06910 ENOG4105D01 (LipO)protein C7M19_RS06915 ENOG4108UMI ABC transporter, permease C7M19_RS06920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C7M19_RS06945 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C7M19_RS06950 ENOG41080E8 Transcriptional regulator, Spx MgsR family C7M19_RS06955 ENOG4105C1G acyl-Coa dehydrogenase C7M19_RS06960 ENOG4105CHU acetyl-coa acetyltransferase C7M19_RS06990 ENOG41067TZ transcriptional regulator, MarR family C7M19_RS06995 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M19_RS07000 ENOG4105C5Q Transcriptional regulator C7M19_RS07020 ENOG4105E0A ABC, transporter C7M19_RS07035 ENOG4105E1F short-chain dehydrogenase reductase C7M19_RS07040 ENOG4105HUF DNA protection during starvation protein C7M19_RS07045 ENOG4105C0H protease C7M19_RS07055 ENOG4105F3H Histidine kinase C7M19_RS07065 ENOG41067SE Tetr family transcriptional regulator C7M19_RS07070 ENOG4105C9Q fumarate hydratase class II C7M19_RS07095 ENOG4105WH1 Two component transcriptional regulator luxr family C7M19_RS07100 ENOG4105ENE Histidine kinase C7M19_RS07115 ENOG41087YS Phage shock protein A C7M19_RS07130 ENOG4108WBT adenosyltransferase C7M19_RS07135 ENOG4105E0A ABC, transporter C7M19_RS07140 ENOG4105EHG Permease protein C7M19_RS07145 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C7M19_RS07150 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M19_RS07155 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C7M19_RS07165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M19_RS07175 ENOG4106DF4 Sigma-70, region 4 C7M19_RS07185 ENOG4105F0F Oxalate decarboxylase C7M19_RS07195 ENOG4105E0A ABC, transporter C7M19_RS07200 ENOG4105EHG Permease protein C7M19_RS07205 ENOG4105DQ5 transport system permease protein C7M19_RS07215 ENOG4105D5Q Arginine ornithine antiporter C7M19_RS07225 ENOG4107K5X Membrane-bound metal-dependent hydrolase C7M19_RS07230 ENOG4107QZ2 Sulfatase C7M19_RS07235 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C7M19_RS07240 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C7M19_RS07245 ENOG4105E0C molybdate abc transporter C7M19_RS07250 ENOG4105WH1 Two component transcriptional regulator luxr family C7M19_RS07255 ENOG4105BZU Histidine kinase C7M19_RS07260 ENOG4105CJ1 ABC, transporter C7M19_RS07270 ENOG4108KYE ABC-2 type transporter C7M19_RS07285 ENOG4105EEQ Na H antiporter C7M19_RS07290 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C7M19_RS07295 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M19_RS07300 ENOG4105EEM helicase C7M19_RS07305 ENOG4105EN6 Membrane C7M19_RS07320 ENOG4107ZQN disulfide bond C7M19_RS07325 ENOG4105C59 p-type ATPase C7M19_RS07330 ENOG4105C59 p-type ATPase C7M19_RS07335 ENOG410681U heavy metal transport detoxification protein C7M19_RS07340 ENOG4105VPX protein, conserved in bacteria C7M19_RS07345 ENOG4105D9R oxidoreductase C7M19_RS07350 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M19_RS07385 ENOG4105DEN Luciferase family C7M19_RS07390 ENOG4105CDA abc transporter atp-binding protein C7M19_RS07415 ENOG4108XSB acetyltransferase, (GNAT) family C7M19_RS07420 ENOG4108KSA LysR family transcriptional regulator C7M19_RS07425 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M19_RS07430 ENOG41067XF inhibitor C7M19_RS07440 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C7M19_RS07445 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C7M19_RS07455 ENOG4105XZU Preprotein translocase, subunit SecG C7M19_RS07475 ENOG4105KVH Transcriptional regulator C7M19_RS07500 ENOG4105DA5 (ABC) transporter C7M19_RS07505 ENOG4105R40 Glycine betaine carnitine choline C7M19_RS07510 ENOG4108HQR Glycine betaine C7M19_RS07515 ENOG4105E90 ABC transporter C7M19_RS07520 ENOG4108IJ8 ABC transporter C7M19_RS07525 ENOG4107HG4 Transcriptional regulator C7M19_RS07530 ENOG4105R40 Glycine betaine carnitine choline C7M19_RS07535 ENOG4108HQR Glycine betaine C7M19_RS07540 ENOG4105E90 ABC transporter C7M19_RS07545 ENOG4108IJ8 ABC transporter C7M19_RS07550 ENOG4107HG4 Transcriptional regulator C7M19_RS07555 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C7M19_RS07565 ENOG4105T65 Membrane-associated protein C7M19_RS07570 ENOG4108W0I acetyltransferase C7M19_RS07585 ENOG4105FJR Lmbe family C7M19_RS07600 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M19_RS07605 ENOG4108IAJ Nad-dependent epimerase dehydratase C7M19_RS07610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M19_RS07615 ENOG4107QQG Dehydrogenase C7M19_RS07620 ENOG4105IIU Aminopeptidase C7M19_RS07625 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C7M19_RS07630 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C7M19_RS07635 ENOG4105CP7 Triose-phosphate isomerase C7M19_RS07640 ENOG4105BZA Phosphoglycerate kinase C7M19_RS07645 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M19_RS07660 ENOG4105CMD Transcriptional regulator, GntR family C7M19_RS07665 ENOG4105DEN Luciferase family C7M19_RS07675 ENOG4105GZI Transcriptional regulator C7M19_RS07680 ENOG4107RT3 EamA-like transporter family C7M19_RS07705 ENOG410667J hydrolase C7M19_RS07715 ENOG4106KNT transcriptional regulator C7M19_RS07720 ENOG4105CMG Carbohydrate kinase C7M19_RS07725 ENOG4105C6Z Gluconate C7M19_RS07735 ENOG4107QR9 Iron-sulfur cluster binding protein C7M19_RS07740 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M19_RS07745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS07750 ENOG4105JXH GntR family transcriptional regulator C7M19_RS07755 ENOG4105DAA L-lactate C7M19_RS07760 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS07770 ENOG4108ZPC Polysaccharide pyruvyl transferase C7M19_RS07775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M19_RS07780 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C7M19_RS07785 ENOG4105D3Q Sugar transferase C7M19_RS07795 ENOG4105K64 Glycosyl transferase, family 2 C7M19_RS07805 ENOG4107QRS glycosyltransferase group 2 family protein C7M19_RS07810 ENOG41068W6 Capsular polysaccharide biosynthesis protein C7M19_RS07815 ENOG4108KMV Glycosyl transferase (Group 1 C7M19_RS07820 ENOG4105K64 Glycosyl transferase, family 2 C7M19_RS07825 ENOG4108PQP glycosyl transferase group 1 C7M19_RS07835 ENOG4108QV3 biosynthesis protein C7M19_RS07840 ENOG4105HTX biosynthesis protein C7M19_RS07850 ENOG4105EBR Carboxylesterase C7M19_RS07860 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M19_RS07870 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C7M19_RS07875 ENOG4105PY6 Phenolic acid decarboxylase C7M19_RS07880 ENOG4105NI3 Protein of unknown function (DUF3237) C7M19_RS07915 ENOG4108HKT sucrose-6-phosphate hydrolase C7M19_RS07920 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) C7M19_RS07925 ENOG4105ETE Transcriptional regulator (LacI family C7M19_RS07930 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C7M19_RS07935 ENOG4108KAM Transcriptional regulator C7M19_RS07940 ENOG4105C7F AcnD-accessory protein PrpF C7M19_RS07950 ENOG4108URH decarboxylase C7M19_RS07955 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C7M19_RS07960 ENOG4105CHH sulfate transporter C7M19_RS07965 ENOG4108V2W Carbonate dehydratase C7M19_RS07970 ENOG4105C5I Dehydrogenase C7M19_RS07975 ENOG4105GGE ribonuclease C7M19_RS07990 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C7M19_RS07995 ENOG4105KRI phosphocarrier protein (HPr C7M19_RS08000 ENOG4105CIE May be required for sporulation (By similarity) C7M19_RS08005 ENOG4105CHW UPF0052 protein C7M19_RS08010 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C7M19_RS08015 ENOG4108Z4K mutator MutT protein C7M19_RS08020 ENOG4105C3M thioredoxin reductase C7M19_RS08035 ENOG4105BZU Histidine kinase C7M19_RS08040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS08045 ENOG4105BZ1 (ABC) transporter C7M19_RS08050 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C7M19_RS08055 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C7M19_RS08060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C7M19_RS08065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C7M19_RS08070 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C7M19_RS08075 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C7M19_RS08080 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C7M19_RS08085 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C7M19_RS08095 ENOG4108S4C acetyltransferase C7M19_RS08100 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C7M19_RS08110 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C7M19_RS08115 ENOG4105CE4 GlcNAc 6-P deacetylase C7M19_RS08120 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M19_RS08125 ENOG4105FDP GntR family transcriptional regulator C7M19_RS08130 ENOG4105J7D transcriptional regulator C7M19_RS08135 ENOG41088CQ domain protein C7M19_RS08140 ENOG41086DT Membrane protein of unknown function C7M19_RS08145 ENOG41067S9 phage shock protein C, PspC C7M19_RS08150 ENOG4108PY7 C7M19_RS08165 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C7M19_RS08170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C7M19_RS08185 ENOG4105MKU Transcriptional regulator C7M19_RS08205 ENOG4105CN1 protease C7M19_RS08210 ENOG4108M26 parallel beta-helix repeat protein C7M19_RS08215 ENOG4105CRP Part of the ABC transporter FtsEX involved in C7M19_RS08220 ENOG4105CAK Cell division ATP-binding protein ftsE C7M19_RS08240 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C7M19_RS08245 ENOG4105MS2 ribosomal subunit Interface protein C7M19_RS08260 ENOG4105MQ3 flagellar protein FliS C7M19_RS08265 ENOG4107RT6 flagellar hook-associated C7M19_RS08270 ENOG4105I03 Flagellin C7M19_RS08275 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C7M19_RS08280 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C7M19_RS08290 ENOG4105DTJ flagellar hook-associated protein C7M19_RS08295 ENOG4105E1Q flagellar hook-associated protein C7M19_RS08310 ENOG4105RU3 C7M19_RS08315 ENOG41081UC Inherit from COG: Competence protein C7M19_RS08335 ENOG4105WH1 Two component transcriptional regulator luxr family C7M19_RS08340 ENOG4105BZU Histidine kinase C7M19_RS08345 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C7M19_RS08350 ENOG4108KGH TRANSCRIPTIONal C7M19_RS08355 ENOG4105ESV Glycosyl transferase, family 4 C7M19_RS08360 ENOG4107EF8 Glycosyl transferase (Group 1 C7M19_RS08375 ENOG4105QZI O-Antigen Polymerase C7M19_RS08380 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M19_RS08385 ENOG4107RA4 Glycosyl transferase (Group 1 C7M19_RS08390 ENOG4105PSV Polysaccharide Biosynthesis Protein C7M19_RS08395 ENOG4105D3Q Sugar transferase C7M19_RS08400 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M19_RS08405 ENOG4105JFG SpoIID LytB domain protein C7M19_RS08420 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C7M19_RS08425 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M19_RS08430 ENOG4105EY8 ABC transporter C7M19_RS08440 ENOG4107SJB teichoic acid biosynthesis C7M19_RS08450 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C7M19_RS08460 ENOG4107RZX Teichoic acid biosynthesis protein C7M19_RS08470 ENOG4105DG6 mannose-6-phosphate isomerase C7M19_RS08485 ENOG4108NHD germination protein C7M19_RS08490 ENOG4107R8N Glycosyl transferase, family 2 C7M19_RS08495 ENOG4105C54 Major Facilitator superfamily C7M19_RS08500 ENOG4108KGH TRANSCRIPTIONal C7M19_RS08505 ENOG4105J7I hydrolase C7M19_RS08510 ENOG4106UBQ C7M19_RS08515 ENOG4105K4H Nlp p60 protein C7M19_RS08525 ENOG4105PNM synthesis protein C7M19_RS08535 ENOG4105N98 Capsule biosynthesis protein capB C7M19_RS08540 ENOG4105E1K spore germination protein C7M19_RS08555 ENOG4105ETE Transcriptional regulator (LacI family C7M19_RS08560 ENOG4108RVA ribokinase C7M19_RS08565 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C7M19_RS08570 ENOG4105C2J ABC transporter C7M19_RS08575 ENOG4105CNN ABC, transporter C7M19_RS08580 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C7M19_RS08590 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M19_RS08595 ENOG4107FQX Alpha-acetolactate decarboxylase C7M19_RS08605 ENOG4107RSM transcriptional regulator C7M19_RS08620 ENOG4106UIA C7M19_RS08635 ENOG4107XC4 flavin reductase domain protein, FMN-binding C7M19_RS08645 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M19_RS08655 ENOG4105CAH Chromate C7M19_RS08660 ENOG4105FGV Chromate C7M19_RS08665 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C7M19_RS08695 ENOG4108XI2 Domain of unknown function (DUF1963) C7M19_RS08700 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M19_RS08705 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C7M19_RS08710 ENOG4107YJ4 chain length determinant protein C7M19_RS08715 ENOG4105HTX biosynthesis protein C7M19_RS08725 ENOG4105KBK Zinc finger, swim domain protein C7M19_RS08730 ENOG4105C0D helicase C7M19_RS08735 ENOG410667J hydrolase C7M19_RS08740 ENOG4105E98 transcriptional regulator DeoR family C7M19_RS08745 ENOG4105Z8H single-stranded DNA-binding protein C7M19_RS08760 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C7M19_RS08765 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C7M19_RS08775 ENOG4105CGA flagellar basal-body rod protein FlgG C7M19_RS08785 ENOG4105DFF Rod shape-determining protein mreb C7M19_RS08790 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C7M19_RS08795 ENOG4107MII Sugar-specific transcriptional regulator TrmB C7M19_RS08800 ENOG4105CZM Major Facilitator C7M19_RS08805 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C7M19_RS08810 ENOG41080V3 Major Facilitator superfamily C7M19_RS08815 ENOG4105D3W isochorismatase C7M19_RS08820 ENOG4105BZU Histidine kinase C7M19_RS08830 ENOG4105CNI cell division protein FtsW C7M19_RS08835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C7M19_RS08845 ENOG4105FRN stage II sporulation protein C7M19_RS08850 ENOG4107TCE N-acetyltransferase C7M19_RS08865 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M19_RS08870 ENOG4106BRK C7M19_RS08875 ENOG4107T94 Endo-14-beta-xylanase C7M19_RS08880 ENOG4108Z40 Transcriptional regulator C7M19_RS08885 ENOG4105CQM Urea amidohydrolase subunit alpha C7M19_RS08890 ENOG4105KI2 Urea amidohydrolase subunit beta C7M19_RS08895 ENOG4108YZ9 Urea amidohydrolase subunit gamma C7M19_RS08915 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C7M19_RS08920 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C7M19_RS08925 ENOG4108TF4 von Willebrand factor, type A C7M19_RS08940 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M19_RS08950 ENOG4106778 Protein of unknown function (DUF1146) C7M19_RS08960 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C7M19_RS08965 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C7M19_RS08970 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C7M19_RS08975 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C7M19_RS08980 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C7M19_RS08995 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C7M19_RS09005 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C7M19_RS09010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C7M19_RS09015 ENOG4108UIC UPF0340 protein C7M19_RS09020 ENOG4108YZG isomerase C7M19_RS09025 ENOG4107WAU Protein tyrosine phosphatase C7M19_RS09030 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C7M19_RS09035 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M19_RS09045 ENOG4108ZXQ stage ii sporulation protein r C7M19_RS09060 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C7M19_RS09065 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C7M19_RS09070 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C7M19_RS09080 ENOG4107TT2 Auxin Efflux Carrier C7M19_RS09085 ENOG4105C6K Malic enzyme C7M19_RS09090 ENOG4107104 thymidine kinase C7M19_RS09095 ENOG41082DI 50s ribosomal protein l31 C7M19_RS09100 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C7M19_RS09105 ENOG4105CBT Fructose-1,6-bisphosphatase C7M19_RS09110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M19_RS09120 ENOG4105D2N Aldolase C7M19_RS09125 ENOG410812K response regulator receiver protein C7M19_RS09135 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C7M19_RS09145 ENOG4105DF6 Fe-S oxidoreductase C7M19_RS09155 ENOG4105E5J UV damage endonuclease C7M19_RS09165 ENOG4105BZ1 (ABC) transporter C7M19_RS09170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M19_RS09185 ENOG4105R3A Nitrate reductase C7M19_RS09190 ENOG4108IUE nitrate reductase beta subunit C7M19_RS09210 ENOG4107V6Q Cyclic nucleotide-binding domain C7M19_RS09220 ENOG4105C75 arginyL-tRNA synthetase C7M19_RS09225 ENOG410684U Domain of unknown function (DUF1934) C7M19_RS09245 ENOG4107JM4 Tetratricopeptide repeat C7M19_RS09290 ENOG4105CYW agmatinase C7M19_RS09295 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C7M19_RS09300 ENOG4105BZ4 penicillin-binding protein C7M19_RS09310 ENOG4108XFG YwhD family C7M19_RS09315 ENOG4108Z4T Peptidase M50 C7M19_RS09320 ENOG41069HH 4-oxalocrotonate tautomerase C7M19_RS09325 ENOG41067TZ transcriptional regulator, MarR family C7M19_RS09330 ENOG4105CUB amino acid C7M19_RS09340 ENOG4105DCI Phosphohydrolase C7M19_RS09350 ENOG4108VCI transcription factor, rsfa family C7M19_RS09355 ENOG4105K7K Transcriptional regulator C7M19_RS09365 ENOG4105CJ1 ABC, transporter C7M19_RS09370 ENOG4108TU7 Inherit from COG: (ABC) transporter C7M19_RS09395 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C7M19_RS09400 ENOG4105DUM transcriptional regulator, lysR family C7M19_RS09405 ENOG4105HMI Membrane C7M19_RS09410 ENOG4108IJ2 phosphate acetyltransferase C7M19_RS09415 ENOG4107JTW chlorite dismutase C7M19_RS09425 ENOG4105CHM Aminotransferase C7M19_RS09455 ENOG4105FCW Major Facilitator superfamily C7M19_RS09460 ENOG4105C2C drug resistance transporter, Bcr CflA C7M19_RS09475 ENOG4105C26 Dehydrogenase C7M19_RS09480 ENOG4105D82 Glutamate dehydrogenase C7M19_RS09490 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C7M19_RS09495 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C7M19_RS09500 ENOG4105C1B dTDP-glucose 4-6-dehydratase C7M19_RS09505 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C7M19_RS09510 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C7M19_RS09515 ENOG4107TY6 Acylneuraminate cytidylyltransferase C7M19_RS09525 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C7M19_RS09530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M19_RS09565 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C7M19_RS09570 ENOG4108RJ9 Glycosyl transferase, family 2 C7M19_RS09590 ENOG4105DWF phosphomethylpyrimidine kinase C7M19_RS09605 ENOG4105C5Y PTS System C7M19_RS09620 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M19_RS09625 ENOG4105DEN Luciferase family C7M19_RS09630 ENOG4108DBC nitroreductase C7M19_RS09640 ENOG4105I4A GCN5-related N-acetyltransferase C7M19_RS09660 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M19_RS09665 ENOG4105E2S oxidase) subunit II C7M19_RS09670 ENOG4107BMA Transglycosylase associated protein C7M19_RS09680 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C7M19_RS09685 ENOG4105WH5 Teichoic acid glycosylation protein C7M19_RS09710 ENOG4107ZXU DSBA oxidoreductase C7M19_RS09715 ENOG4105DBE peroxidase C7M19_RS09720 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C7M19_RS09725 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase C7M19_RS09730 ENOG4105CMU LysR family (Transcriptional regulator C7M19_RS09735 ENOG4105VAW lrga family C7M19_RS09740 ENOG41067MG lrgb family C7M19_RS09750 ENOG4107TXC Transcriptional regulator C7M19_RS09760 ENOG4105DR4 Methyltransferase C7M19_RS09770 ENOG4105CK1 PTS System C7M19_RS09775 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C7M19_RS09780 ENOG4105X1N Glycosyl transferase family 8 C7M19_RS09790 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C7M19_RS09800 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C7M19_RS09805 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C7M19_RS09810 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) C7M19_RS09815 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C7M19_RS09820 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M19_RS09825 ENOG4105F8D glycoside hydrolase family 4 C7M19_RS09830 ENOG4105VCP PTS System C7M19_RS09835 ENOG4105CK1 PTS System C7M19_RS09840 ENOG4105VZJ PTS System C7M19_RS09845 ENOG4105EMD TRANSCRIPTIONal C7M19_RS09855 ENOG4105DQ5 transport system permease protein C7M19_RS09860 ENOG4105EHG Permease protein C7M19_RS09870 ENOG41082YX Transcriptional regulator, arsr family C7M19_RS09875 ENOG4107R5R arsenical pump membrane protein C7M19_RS09880 ENOG4105VZJ PTS System C7M19_RS09885 ENOG4105VCP PTS System C7M19_RS09890 ENOG4105CK1 PTS System C7M19_RS09895 ENOG4105CS2 ec 3.2.1.21 C7M19_RS09900 ENOG4105EVU fructokinase C7M19_RS09905 ENOG4105DG6 mannose-6-phosphate isomerase C7M19_RS09915 ENOG4105CH6 catalase C7M19_RS09920 ENOG4107QHE Choloylglycine hydrolase C7M19_RS09925 ENOG4105ETS cytosine purines uracil thiamine allantoin C7M19_RS09930 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C7M19_RS09935 ENOG4108JJ8 (ABC) transporter C7M19_RS09940 ENOG4108JJ9 ABC, transporter C7M19_RS09945 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C7M19_RS09950 ENOG4105C4M (Ubiquinol oxidase) subunit I C7M19_RS09955 ENOG4105D2K citrate carrier protein C7M19_RS09960 ENOG4107BJW polysaccharide deacetylase C7M19_RS09975 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C7M19_RS09985 ENOG4105CMR udp-glucose 4-epimerase C7M19_RS09990 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M19_RS10005 ENOG4105DHI Methyltransferase C7M19_RS10025 ENOG4105CH6 catalase C7M19_RS10030 ENOG4105D4T Citrate transporter C7M19_RS10040 ENOG4105CID antiterminator C7M19_RS10045 ENOG4105DEU major facilitator superfamily C7M19_RS10050 ENOG4105C1J atp-dependent rna helicase C7M19_RS10115 ENOG4105CNA YD repeat protein C7M19_RS10120 ENOG4108NR7 pectate lyase C7M19_RS10130 ENOG4107YZX Universal stress protein C7M19_RS10190 ENOG4106Z5D Glycoside Hydrolase Family 43 C7M19_RS10200 ENOG4105C84 Histidine ammonia-lyase C7M19_RS10205 ENOG4105CGP Urocanate hydratase C7M19_RS10210 ENOG4105CI2 imidazolone-5-propionate hydrolase C7M19_RS10215 ENOG4107W25 arginase agmatinase formiminoglutamase C7M19_RS10225 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C7M19_RS10230 ENOG4105D9N nucleoside C7M19_RS10235 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C7M19_RS10240 ENOG4107RHR regulatoR C7M19_RS10245 ENOG410667J hydrolase C7M19_RS10275 ENOG4108V5C ABC transporter C7M19_RS10310 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M19_RS10335 ENOG4105WZ4 isomerase C7M19_RS10340 ENOG4105F0H myo-inositol catabolism protein C7M19_RS10345 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M19_RS10355 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M19_RS10365 ENOG4105EDK PfkB domain protein C7M19_RS10375 ENOG4105C26 Dehydrogenase C7M19_RS10385 ENOG4105CPC Aldo Keto reductase C7M19_RS10390 ENOG4107QNK )-transporter C7M19_RS10395 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C7M19_RS10405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C7M19_RS10410 ENOG4108S01 response regulator C7M19_RS10415 ENOG4108ZGX Histidine kinase C7M19_RS10420 ENOG4105ECK Fatty Acid Desaturase C7M19_RS10425 ENOG4105ST3 Transcriptional regulator C7M19_RS10430 ENOG4105C26 Dehydrogenase C7M19_RS10435 ENOG4108ITS PQQ enzyme repeat C7M19_RS10445 ENOG4105WAB arsR family transcriptional regulator C7M19_RS10450 ENOG4105F27 Major Facilitator C7M19_RS10455 ENOG41085PJ rdd domain containing protein C7M19_RS10465 ENOG4105D3R alkyl hydroperoxide reductase C7M19_RS10470 ENOG4108JU3 Alkyl hydroperoxide reductase C7M19_RS10475 ENOG4107R3N Filamentation induced by cAMP protein fic C7M19_RS10480 ENOG4105C85 amino acid C7M19_RS10485 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C7M19_RS10490 ENOG4108XHQ (2Fe-2S)-binding domain protein C7M19_RS10510 ENOG4105XRQ Xanthine dehydrogenase accessory factor C7M19_RS10540 ENOG4105C4R Atp-dependent dna helicase C7M19_RS10565 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C7M19_RS10580 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C7M19_RS10585 ENOG4105CPC Aldo Keto reductase C7M19_RS10590 ENOG4105WQG acetyltransferase C7M19_RS10600 ENOG41066UZ arginase EC 3.5.3.1 C7M19_RS10605 ENOG4108IQI permease C7M19_RS10610 ENOG4105C8Y Acetylornithine aminotransferase C7M19_RS10620 ENOG41082BM Transcriptional regulator, arsr family C7M19_RS10625 ENOG4108JUB Transcriptional regulator C7M19_RS10635 ENOG4105C5H ABC transporter C7M19_RS10650 ENOG4105D06 uba thif-type nad fad binding protein C7M19_RS10655 ENOG41062D9 Histidine kinase C7M19_RS10660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS10665 ENOG4105C0H protease C7M19_RS10670 ENOG4105Q2H domain protein C7M19_RS10685 ENOG4105BZU Histidine kinase C7M19_RS10690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS10715 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C7M19_RS10720 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C7M19_RS10725 ENOG4105CDU Replicative dna helicase C7M19_RS10750 ENOG4105EDW glycosyl transferase, family 39 C7M19_RS10765 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M19_RS10770 ENOG4105CPK Glycosyl transferase (Group 1 C7M19_RS10790 ENOG4105BZR domain protein C7M19_RS10795 ENOG4108XMW Membrane C7M19_RS10810 ENOG4105KVH Transcriptional regulator C7M19_RS10815 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C7M19_RS10820 ENOG4108UZ3 Transporter C7M19_RS10825 ENOG4105EDQ levansucrase EC 2.4.1.10 C7M19_RS10830 ENOG4108HKT sucrose-6-phosphate hydrolase C7M19_RS10835 ENOG4107XBN GntR Family Transcriptional Regulator C7M19_RS10850 ENOG4107V2S Transcriptional regulator C7M19_RS10855 ENOG4108VP3 Lysine exporter protein (LysE YggA) C7M19_RS10860 ENOG4105D94 Major Facilitator Superfamily C7M19_RS10865 ENOG4107RSM transcriptional regulator C7M19_RS10875 ENOG4108TVJ Nitroreductase C7M19_RS10880 ENOG4105FS7 Transcriptional regulator C7M19_RS10890 ENOG4108U05 Transcriptional regulator C7M19_RS10895 ENOG41082BV acetyltransferase C7M19_RS10905 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C7M19_RS10910 ENOG4105CMU LysR family (Transcriptional regulator C7M19_RS10915 ENOG4105DTD Dehydrogenase C7M19_RS10940 ENOG4107Y9U Membrane C7M19_RS10945 ENOG4105C7Z Conserved Protein C7M19_RS10950 ENOG4107FCW Abortive infection protein C7M19_RS10960 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C7M19_RS10970 ENOG4105CGK Exodeoxyribonuclease III C7M19_RS10975 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M19_RS10985 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C7M19_RS10990 ENOG4108UUM single-stranded DNA-binding protein C7M19_RS10995 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C7M19_RS11000 ENOG4105C3G gtp-binding protein C7M19_RS11005 ENOG4108J2R molybdopterin oxidoreductase C7M19_RS11010 ENOG4105VDK protein, conserved in bacteria C7M19_RS11025 ENOG4108ZDA Sporulation protein YyaC C7M19_RS11030 ENOG4105FA0 parb-like partition protein C7M19_RS11035 ENOG4107QJE Chromosome Partitioning Protein C7M19_RS11050 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C7M19_RS11055 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C7M19_RS11070 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C7M19_RS11080 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C7M19_RS11085 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C7M19_RS11090 ENOG410848D S4 domain protein YaaA C7M19_RS11095 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C7M19_RS11105 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M19_RS11110 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M19_RS11145 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C7M19_RS11155 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C7M19_RS11160 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C7M19_RS11165 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C7M19_RS11170 ENOG4105BZW Glycerate kinase C7M19_RS11180 ENOG4105ZMH deoxynucleoside kinase C7M19_RS11190 ENOG4105VRS hydrolase family 18 C7M19_RS11195 ENOG4105GTG Isochorismatase C7M19_RS11200 ENOG4108Z6B deaminase C7M19_RS11210 ENOG4105C6E dna polymerase iii C7M19_RS11215 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C7M19_RS11220 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C7M19_RS11230 ENOG41067KS pro-sigma K processing C7M19_RS11270 ENOG4105CDW Resistance protein C7M19_RS11275 ENOG4105CXN decarboxylase C7M19_RS11280 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C7M19_RS11285 ENOG4105X0R protein from nitrogen regulatory protein P-II C7M19_RS11290 ENOG4105XVJ Protein of unknown function (DUF327) C7M19_RS11295 ENOG4105FA2 dna polymerase iii C7M19_RS11300 ENOG4105MA4 psp1 domain protein C7M19_RS11310 ENOG41060K3 Methyltransferase C7M19_RS11315 ENOG4105VC4 domain protein C7M19_RS11320 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C7M19_RS11325 ENOG4105KRN Transcriptional regulator, abrb family C7M19_RS11330 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C7M19_RS11335 ENOG4105F8V Hydrolase, tatD family C7M19_RS11340 ENOG41069ER domain protein C7M19_RS11350 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C7M19_RS11355 ENOG4105XFA sporulation peptidase YabG C7M19_RS11360 ENOG4105W42 Veg protein C7M19_RS11365 ENOG4105XEW small acid-soluble spore protein C7M19_RS11370 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C7M19_RS11375 ENOG4105DFT pur operon repressor C7M19_RS11380 ENOG4105KME endoribonuclease L-psp C7M19_RS11385 ENOG4105K4W Could be involved in septation (By similarity) C7M19_RS11390 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C7M19_RS11395 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C7M19_RS11400 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C7M19_RS11415 ENOG4108JA2 transcriptioN-repair coupling factor C7M19_RS11420 ENOG4108M14 stage v sporulation protein t C7M19_RS11430 ENOG4108IY2 MazG family C7M19_RS11435 ENOG41082I2 s4 domain protein C7M19_RS11440 ENOG4105VYY sporulation protein yabp C7M19_RS11455 ENOG41060GV RNA binding s1 domain protein C7M19_RS11485 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C7M19_RS11490 ENOG4108UGV hypoxanthine phosphoribosyltransferase C7M19_RS11495 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C7M19_RS11500 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C7M19_RS11505 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C7M19_RS11510 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C7M19_RS11515 ENOG4105C6T cysteine synthase C7M19_RS11520 ENOG4105CRQ synthase (Component I) C7M19_RS11525 ENOG4105DDQ anthranilate synthase C7M19_RS11530 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C7M19_RS11535 ENOG4105EEI dihydropteroate synthase C7M19_RS11540 ENOG4105KRF dihydroneopterin aldolase C7M19_RS11545 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C7M19_RS11555 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C7M19_RS11560 ENOG4105CRK lysyL-tRNA synthetase C7M19_RS11645 ENOG4108Z0C Uvrb UvrC protein C7M19_RS11650 ENOG41066A3 ATP guanido phosphotransferase C7M19_RS11660 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C7M19_RS11665 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C7M19_RS11670 ENOG4105CTP PilT protein domain protein C7M19_RS11675 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C7M19_RS11680 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C7M19_RS11685 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C7M19_RS11690 ENOG4105D7W serine acetyltransferase C7M19_RS11700 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C7M19_RS11705 ENOG4105C2N RNA methyltransferase TrmH family group 3 C7M19_RS11710 ENOG4105M0M Tetracycline resistance protein C7M19_RS11730 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C7M19_RS11735 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C7M19_RS11745 ENOG4108VZM 50s ribosomal protein L10 C7M19_RS11750 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C7M19_RS11755 ENOG4107Y49 methyltransferase C7M19_RS11760 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M19_RS11765 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M19_RS11770 ENOG4105XPM ribosomal protein C7M19_RS11775 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C7M19_RS11780 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C7M19_RS11785 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C7M19_RS11790 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C7M19_RS11795 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C7M19_RS11800 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C7M19_RS11805 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C7M19_RS11810 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C7M19_RS11815 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C7M19_RS11820 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C7M19_RS11825 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C7M19_RS11830 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C7M19_RS11835 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C7M19_RS11840 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C7M19_RS11845 ENOG41082SA 50s ribosomal protein l29 C7M19_RS11850 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C7M19_RS11865 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C7M19_RS11875 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C7M19_RS11880 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C7M19_RS11885 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C7M19_RS11890 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C7M19_RS11895 ENOG4105VPB 50S ribosomal protein L30 C7M19_RS11900 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C7M19_RS11905 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C7M19_RS11910 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C7M19_RS11915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C7M19_RS11925 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C7M19_RS11935 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C7M19_RS11940 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C7M19_RS11945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M19_RS11950 ENOG4108ZT0 50S ribosomal protein l17 C7M19_RS11955 ENOG4108JJB ABC transporter C7M19_RS11960 ENOG4108JJB ABC transporter C7M19_RS11965 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C7M19_RS11970 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C7M19_RS11975 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C7M19_RS11980 ENOG4108UJD 30S ribosomal protein S9 C7M19_RS11985 ENOG4108I0C methyltransferase C7M19_RS12005 ENOG4105D1F ATP-binding protein C7M19_RS12020 ENOG4108NMV polysaccharide deacetylase C7M19_RS12085 ENOG4108JPW Aminotransferase C7M19_RS12100 ENOG4105CHH sulfate transporter C7M19_RS12110 ENOG4108SA1 esterase C7M19_RS12130 ENOG410874W AraC family transcriptional regulator C7M19_RS12135 ENOG4105EHZ conserved protein UCP016719 C7M19_RS12140 ENOG4105D17 glycoside hydrolase, family 3 domain protein C7M19_RS12155 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C7M19_RS12165 ENOG4105EWC Purine nucleoside phosphorylase C7M19_RS12195 ENOG4105EMN RNA polymerase sigma factor C7M19_RS12205 ENOG4105C8B TIGR00159 family C7M19_RS12210 ENOG4107U5W ybbr family C7M19_RS12215 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C7M19_RS12250 ENOG4106K80 C7M19_RS12260 ENOG41067MG lrgb family C7M19_RS12270 ENOG41061AU MarR family Transcriptional regulator C7M19_RS12295 ENOG4106DDH Sporulation-specific SASP protein C7M19_RS12310 ENOG4107QTZ amino acid C7M19_RS12325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C7M19_RS12330 ENOG4105CXY transporter C7M19_RS12365 ENOG4107SCQ Iron-containing alcohol dehydrogenase C7M19_RS12370 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M19_RS12375 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C7M19_RS12380 ENOG4107ZTW SNARE associated Golgi C7M19_RS12395 ENOG4105C72 UPF0176 protein C7M19_RS12405 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M19_RS12410 ENOG4108IQI permease C7M19_RS12415 ENOG4108J5H Homocysteine s-methyltransferase C7M19_RS12425 ENOG4105CSV Glutaminase C7M19_RS12445 ENOG41076HS cation diffusion facilitator family transporter C7M19_RS12450 ENOG4108TVJ Nitroreductase C7M19_RS12455 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C7M19_RS12460 ENOG4108VGI doxx family C7M19_RS12465 ENOG4105XXY Thioredoxin C7M19_RS12480 ENOG4105DGI Alkaline phosphatase C7M19_RS12485 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M19_RS12490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M19_RS12495 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C7M19_RS12500 ENOG4107EPV Aminotransferase class V C7M19_RS12505 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M19_RS12510 ENOG4105J7D transcriptional regulator C7M19_RS12515 ENOG4107RB3 L-asparaginase C7M19_RS12520 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M19_RS12525 ENOG41060AI SEC-C motif C7M19_RS12530 ENOG4107SET aldo keto reductase C7M19_RS12560 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M19_RS12570 ENOG4105DSE periplasmic solute binding protein C7M19_RS12575 ENOG4105DIK (ABC) transporter C7M19_RS12585 ENOG4105DEN Luciferase family C7M19_RS12590 ENOG4108N0M stress protein C7M19_RS12595 ENOG4106FN3 tellurium resistance protein C7M19_RS12600 ENOG4106FN3 tellurium resistance protein C7M19_RS12605 ENOG4107TS3 membrane protein, TerC C7M19_RS12610 ENOG4108TTB tellurium resistance protein C7M19_RS12620 ENOG41079KZ Major Facilitator Superfamily C7M19_RS12625 ENOG4108IJ7 Glycine betaine C7M19_RS12630 ENOG4107SQ8 Glycine betaine C7M19_RS12660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M19_RS12690 ENOG4105EIG urea carboxylase-associated protein 1 C7M19_RS12695 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C7M19_RS12705 ENOG4105I1F Resistance protein C7M19_RS12710 ENOG4108WBH protein TIM barrel C7M19_RS12715 ENOG4105DJB Major Facilitator Superfamily C7M19_RS12720 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C7M19_RS12725 ENOG4105I82 acetyl xylan esterase C7M19_RS12730 ENOG410756H nucleotidyltransferase C7M19_RS12740 ENOG4105C26 Dehydrogenase C7M19_RS12745 ENOG4105CK7 Sodium proline symporter C7M19_RS12750 ENOG4107YHD transcriptional regulator C7M19_RS12755 ENOG4105CAY ferredoxin--nadp reductase C7M19_RS12760 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M19_RS12765 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C7M19_RS12770 ENOG4108IFG nitrite reductase, (NAD(P)H) C7M19_RS12775 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C7M19_RS12790 ENOG4105CKI cobalamin synthesis protein C7M19_RS12795 ENOG4105E2A Dehydrogenase C7M19_RS12800 ENOG4105HHM rdd domain containing protein C7M19_RS12810 ENOG4105CS2 ec 3.2.1.21 C7M19_RS12825 ENOG41080HJ 6-phospho 3-hexuloisomerase C7M19_RS12830 ENOG4108VA3 3-hexulose-6-phosphate synthase C7M19_RS12835 ENOG4105KVH Transcriptional regulator C7M19_RS12840 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS12860 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C7M19_RS12870 ENOG4105SX7 Transporter C7M19_RS12890 ENOG4105CDA abc transporter atp-binding protein C7M19_RS12895 ENOG4105DRP amino acid AbC transporter C7M19_RS12905 ENOG4106P55 Transcriptional regulator C7M19_RS12910 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C7M19_RS12915 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C7M19_RS12920 ENOG41069ZX C7M19_RS12925 ENOG41069ZX C7M19_RS12930 ENOG4105DUX Transporter C7M19_RS12945 ENOG4105E1K spore germination protein C7M19_RS12960 ENOG4105CPU Monooxygenase C7M19_RS12965 ENOG4108XSB acetyltransferase, (GNAT) family C7M19_RS12970 ENOG4105EAB amino acid AbC transporter C7M19_RS12975 ENOG4108HW4 amino acid AbC transporter C7M19_RS12985 ENOG4105CH2 amidohydrolase C7M19_RS12990 ENOG4108PGP mmge prpd family protein C7M19_RS13000 ENOG4107WD8 ABC transporter, permease C7M19_RS13005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS13010 ENOG4105BZU Histidine kinase C7M19_RS13030 ENOG4105CFH Aspartokinase C7M19_RS13035 ENOG4105DHS permease protein C7M19_RS13040 ENOG4105CM4 permease protein C7M19_RS13045 ENOG4108IPW abc transporter atp-binding protein C7M19_RS13060 ENOG4105R8C Transcriptional regulator C7M19_RS13065 ENOG4108DBC nitroreductase C7M19_RS13070 ENOG41067V3 Antibiotic biosynthesis monooxygenase C7M19_RS13075 ENOG4105YVS arsR family transcriptional regulator C7M19_RS13085 ENOG4108JPW Aminotransferase C7M19_RS13090 ENOG4105C26 Dehydrogenase C7M19_RS13100 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M19_RS13105 ENOG4105KTB nuclear export factor GLE1 C7M19_RS13110 ENOG4108T5E Copper resistance protein C7M19_RS13115 ENOG4108ZYE Transcriptional regulator C7M19_RS13135 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C7M19_RS13155 ENOG4105E7W lamb ycsf family protein C7M19_RS13160 ENOG4105C5A transporter C7M19_RS13165 ENOG4105CFM UPF0317 protein C7M19_RS13170 ENOG4105P4J Allophanate hydrolase, subunit 1 C7M19_RS13180 ENOG4107258 Transcriptional regulator C7M19_RS13185 ENOG4105XJB lipolytic protein G-D-S-L family C7M19_RS13195 ENOG41061CK Antibiotic biosynthesis monooxygenase C7M19_RS13200 ENOG4107RVG penicillin-binding protein C7M19_RS13205 ENOG4107QM2 Aldo Keto reductase C7M19_RS13210 ENOG4105ETD TRANSCRIPTIONal C7M19_RS13220 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M19_RS13235 ENOG410606W general stress protein C7M19_RS13245 ENOG4105VCH membrane C7M19_RS13255 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M19_RS13270 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C7M19_RS13275 ENOG4107R8N Glycosyl transferase, family 2 C7M19_RS13285 ENOG4105C0X amino acid C7M19_RS13320 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C7M19_RS13330 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C7M19_RS13335 ENOG4105RXJ C7M19_RS13340 ENOG4105KPY Small multidrug resistance protein C7M19_RS13345 ENOG4105EU9 C7M19_RS13350 ENOG4105QVS general stress protein C7M19_RS13355 ENOG41082W1 Cupin 2, conserved barrel domain protein C7M19_RS13370 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C7M19_RS13375 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C7M19_RS13380 ENOG4108MRH transcriptional regulatory protein C7M19_RS13385 ENOG4107QJT sodium dicarboxylate symporter C7M19_RS13390 ENOG4106F5Q Membrane C7M19_RS13395 ENOG4105CJ1 ABC, transporter C7M19_RS13410 ENOG4105FDT acyl-CoA dehydrogenase C7M19_RS13430 ENOG4105SZ6 Thioredoxin C7M19_RS13435 ENOG4105CPF Cell wall formation (By similarity) C7M19_RS13440 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C7M19_RS13445 ENOG4105C1J atp-dependent rna helicase C7M19_RS13450 ENOG410905X membrane-flanked domain protein C7M19_RS13455 ENOG4105CKV Membrane C7M19_RS13465 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C7M19_RS13470 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C7M19_RS13475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M19_RS13485 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C7M19_RS13490 ENOG4107MMM Anti-sigma-factor antagonist C7M19_RS13495 ENOG4105FUA antagonist C7M19_RS13500 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C7M19_RS13505 ENOG4107SGM protein serine threonine phosphatase C7M19_RS13510 ENOG4105WN5 stage II sporulation protein C7M19_RS13515 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M19_RS13525 ENOG41064BQ Phosphatase C7M19_RS13540 ENOG410906U SprT-like C7M19_RS13605 ENOG410847I Transcriptional regulator, BadM Rrf2 family C7M19_RS13610 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M19_RS13615 ENOG4105ECP epimerase C7M19_RS13620 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M19_RS13640 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M19_RS13665 ENOG4105C94 Transporter C7M19_RS13670 ENOG4105CSH Transporter C7M19_RS13675 ENOG4105K56 Transcriptional regulator C7M19_RS13685 ENOG4108ZMQ domain protein C7M19_RS13700 ENOG4108Z40 Transcriptional regulator C7M19_RS13705 ENOG4108RYK Nad-dependent epimerase dehydratase C7M19_RS13715 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C7M19_RS13725 ENOG4105ECK Fatty Acid Desaturase C7M19_RS13735 ENOG4105VEQ Cold shock protein C7M19_RS13740 ENOG4108VJ1 Transcriptional regulator (CarD family C7M19_RS13760 ENOG4105IRW patatin-like phospholipase family protein C7M19_RS13770 ENOG41082W1 Cupin 2, conserved barrel domain protein C7M19_RS13785 ENOG4105DNP FAD linked oxidase domain protein C7M19_RS13795 ENOG4105PGM cation diffusion facilitator family transporter C7M19_RS13800 ENOG4105H3G oxidoreductase C7M19_RS13810 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C7M19_RS13820 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C7M19_RS13845 ENOG4105DQ4 alcohol dehydrogenase C7M19_RS13850 ENOG4105VUF Transcriptional regulator C7M19_RS13860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS13895 ENOG4105EQ0 Major Facilitator superfamily C7M19_RS13900 ENOG4108JGH Tetr family transcriptional regulator C7M19_RS13905 ENOG4105T38 integral membrane protein C7M19_RS13910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS13925 ENOG4105E2A Dehydrogenase C7M19_RS13930 ENOG4105PGS Spore coat protein C7M19_RS13940 ENOG4106UW1 Major Facilitator superfamily C7M19_RS13950 ENOG4108UW5 maltose o-acetyltransferase C7M19_RS13955 ENOG4105ENE Histidine kinase C7M19_RS13960 ENOG4108VB1 regulatoR C7M19_RS13965 ENOG4105EYF MMPL domain protein C7M19_RS13985 ENOG4108JYZ YitT family C7M19_RS13995 ENOG4105C2C drug resistance transporter, Bcr CflA C7M19_RS14000 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C7M19_RS14020 ENOG41090E6 transcriptional regulator MERR family C7M19_RS14035 ENOG4105F2W methyltransferase C7M19_RS14040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M19_RS14045 ENOG4105DRR Transcriptional regulator, GntR family C7M19_RS14065 ENOG4105FQP Beta-lactamase C7M19_RS14070 ENOG41090UD (LipO)protein C7M19_RS14075 ENOG4108SUT Major Facilitator Superfamily C7M19_RS14080 ENOG4108TZY GntR Family Transcriptional Regulator C7M19_RS14085 ENOG4105JXH GntR family transcriptional regulator C7M19_RS14090 ENOG4105DJ2 Major Facilitator Superfamily C7M19_RS14110 ENOG4107QTZ amino acid C7M19_RS14130 ENOG4107QNK )-transporter C7M19_RS14170 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C7M19_RS14175 ENOG4105K8N protein family UPF0079, ATPase C7M19_RS14180 ENOG41072GX Peptidase M22 Glycoprotease C7M19_RS14185 ENOG410801F ribosomal-protein-alanine acetyltransferase C7M19_RS14190 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M19_RS14195 ENOG4105C5H ABC transporter C7M19_RS14200 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C7M19_RS14205 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C7M19_RS14210 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M19_RS14215 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M19_RS14225 ENOG4108TYN CAAX amino terminal protease family protein C7M19_RS14230 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C7M19_RS14235 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C7M19_RS14250 ENOG4105PGZ NB-ARC domain C7M19_RS14255 ENOG4105CPQ Dehydrogenase C7M19_RS14260 ENOG4105CT4 transporter C7M19_RS14275 ENOG41087YS Phage shock protein A C7M19_RS14280 ENOG4105DQX Zinc finger domain C7M19_RS14285 ENOG4108WV1 Pfam:DUF477 C7M19_RS14295 ENOG4105EXC Acyl-transferase C7M19_RS14300 ENOG4108P49 AntiSigma factor C7M19_RS14305 ENOG4105JVQ RNA Polymerase C7M19_RS14330 ENOG4107STQ Multicopper oxidase C7M19_RS14335 ENOG4105C85 amino acid C7M19_RS14345 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C7M19_RS14360 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C7M19_RS14375 ENOG4105C7N Xanthine uracil vitamin C permease C7M19_RS14400 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C7M19_RS14405 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C7M19_RS14410 ENOG4105C83 adenylosuccinate lyase C7M19_RS14415 ENOG4105C8V SAICAR synthetase C7M19_RS14420 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C7M19_RS14425 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C7M19_RS14430 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C7M19_RS14440 ENOG4105CXB phosphoribosylaminoimidazole synthetase C7M19_RS14445 ENOG4108V3E phosphoribosylglycinamide formyltransferase C7M19_RS14450 ENOG4105DC1 bifunctional purine biosynthesis protein purh C7M19_RS14455 ENOG4105C12 Phosphoribosylglycinamide synthetase C7M19_RS14470 ENOG4108R5T secreted protein C7M19_RS14475 ENOG4105KGF protein, YerC YecD C7M19_RS14480 ENOG4105CBC glutamate synthase C7M19_RS14490 ENOG4105C4R Atp-dependent dna helicase C7M19_RS14495 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C7M19_RS14505 ENOG4105CRN Aminoglycoside phosphotransferase C7M19_RS14510 ENOG4105KT7 mgtC SapB transporter C7M19_RS14515 ENOG4105CK7 Sodium proline symporter C7M19_RS14520 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M19_RS14525 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C7M19_RS14530 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M19_RS14535 ENOG4108IG5 Transcriptional regulator C7M19_RS14545 ENOG4105CBD Diacylglycerol kinase C7M19_RS14550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M19_RS14560 ENOG4105CJ1 ABC, transporter C7M19_RS14600 ENOG4106BHF C7M19_RS14605 ENOG4105CDY transcriptional regulatory protein C7M19_RS14625 ENOG4105WEF catalase C7M19_RS14630 ENOG4105M18 -acetyltransferase C7M19_RS14640 ENOG4105H67 Protein of unknown function (DUF421) C7M19_RS14645 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C7M19_RS14650 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C7M19_RS14670 ENOG4106I4J membrane C7M19_RS14675 ENOG41082F9 transcriptional regulator C7M19_RS14680 ENOG41061H0 Monooxygenase C7M19_RS14685 ENOG4108R1P C7M19_RS14690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M19_RS14705 ENOG4105CJ1 ABC, transporter C7M19_RS14755 ENOG4105E0M Sulfatase C7M19_RS14760 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C7M19_RS14770 ENOG41090R9 glycosyltransferase C7M19_RS14775 ENOG4107R51 Glycosyl transferase, family 2 C7M19_RS14780 ENOG41090R9 glycosyltransferase C7M19_RS14785 ENOG4105EU0 Major facilitator Superfamily C7M19_RS14790 ENOG4105CUB amino acid C7M19_RS14795 ENOG4105C26 Dehydrogenase C7M19_RS14800 ENOG4105FKZ Methyl-accepting chemotaxis C7M19_RS14805 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M19_RS14810 ENOG4107TVC Glycosyl transferase, family 2 C7M19_RS14815 ENOG4105C5H ABC transporter C7M19_RS14820 ENOG4107SWG transcriptional regulator MERR family C7M19_RS14825 ENOG4105DXB Major Facilitator superfamily C7M19_RS14830 ENOG4105C5H ABC transporter C7M19_RS14835 ENOG4105FDU atp-dependent rna helicase C7M19_RS14845 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C7M19_RS14860 ENOG4108J20 pectate lyase C7M19_RS14865 ENOG4107QPK )-transporter C7M19_RS14890 ENOG4108VAC response regulator C7M19_RS14900 ENOG4108Z6X (sortase) family C7M19_RS14910 ENOG4108MRH transcriptional regulatory protein C7M19_RS14935 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) C7M19_RS14940 ENOG4108RPX mosc domain containing protein C7M19_RS14960 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C7M19_RS15000 ENOG4105C5Y PTS System C7M19_RS15005 ENOG4105CG3 alpha amylase, catalytic region C7M19_RS15010 ENOG4107414 GntR family transcriptional regulator C7M19_RS15015 ENOG4108RCM Nitroreductase C7M19_RS15030 ENOG4105CGH 5'-nucleotidase C7M19_RS15035 ENOG4107RKG DJ-1/PfpI family C7M19_RS15040 ENOG4105ETE Transcriptional regulator (LacI family C7M19_RS15045 ENOG4105E2X shikimate dehydrogenase C7M19_RS15050 ENOG4105FF2 Type I DHQase C7M19_RS15065 ENOG4105KJF protein tyrosine phosphatase C7M19_RS15075 ENOG4107U9T Pfam:Ribonuclease_BN C7M19_RS15085 ENOG4108ISG Major Facilitator C7M19_RS15090 ENOG4105UPD Calcium Proton C7M19_RS15100 ENOG4105D8X mechanosensitive ion channel C7M19_RS15120 ENOG4106KE4 Dehydrogenase C7M19_RS15130 ENOG4105D7N magnesium and cobalt transport protein CorA C7M19_RS15140 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M19_RS15160 ENOG4107RUY (E1 component), alpha subunit C7M19_RS15170 ENOG4107QKR Dehydrogenase C7M19_RS15180 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C7M19_RS15190 ENOG4105F8D glycoside hydrolase family 4 C7M19_RS15195 ENOG4108Q3X Transcriptional regulator C7M19_RS15200 ENOG4105CI1 PTS System C7M19_RS15210 ENOG4105BZ1 (ABC) transporter C7M19_RS15215 ENOG4105BZ1 (ABC) transporter C7M19_RS15225 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C7M19_RS15230 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M19_RS15235 ENOG4105U3E Transcriptional regulator C7M19_RS15240 ENOG4105DYS nad(p)h dehydrogenase (quinone) C7M19_RS15245 ENOG4105H93 Acyltransferase family C7M19_RS15260 ENOG4108YYS metal-dependent hydrolase (By similarity) C7M19_RS15265 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M19_RS15270 ENOG410834F Transcriptional regulator C7M19_RS15280 ENOG4105JAB phenazine biosynthesis protein, phzf family C7M19_RS15285 ENOG4107Y03 Nitroreductase C7M19_RS15300 ENOG4105ECP epimerase C7M19_RS15305 ENOG410902V Modulates RecA activity (By similarity) C7M19_RS15315 ENOG4105F27 Major Facilitator C7M19_RS15325 ENOG4108TCS Glutamyl endopeptidase C7M19_RS15345 ENOG4106AKJ C7M19_RS15350 ENOG4105D74 hydrolase C7M19_RS15355 ENOG4105CKK Glycosyl transferase, family 2 C7M19_RS15360 ENOG4105EJV Membrane C7M19_RS15365 ENOG41067AE Membrane-bound metal-dependent hydrolase C7M19_RS15370 ENOG4105CEN a g-specific adenine glycosylase C7M19_RS15375 ENOG4106BXE C7M19_RS15380 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C7M19_RS15400 ENOG4105BZ1 (ABC) transporter C7M19_RS15405 ENOG4107NBY Membrane C7M19_RS15410 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C7M19_RS15415 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M19_RS15420 ENOG4105G5W regulator Fur family C7M19_RS15425 ENOG4105TUA UPF0295 protein C7M19_RS15535 ENOG4105EC3 peptidase S51, dipeptidase E C7M19_RS15540 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C7M19_RS15545 ENOG4105DNP FAD linked oxidase domain protein C7M19_RS15555 ENOG4105DEF Extracellular solute-binding protein, family 5 C7M19_RS15565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M19_RS15570 ENOG4105C3U ABC transporter C7M19_RS15575 ENOG4108JQ7 (ABC) transporter C7M19_RS15590 ENOG4105E2Y ABC, transporter C7M19_RS15595 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C7M19_RS15600 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C7M19_RS15610 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C7M19_RS15615 ENOG4107D63 C7M19_RS15620 ENOG4105VZ8 Transcriptional regulator C7M19_RS15635 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C7M19_RS15645 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C7M19_RS15665 ENOG4105CYN Serine protein kinase C7M19_RS15675 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C7M19_RS15680 ENOG4105CW7 secretion protein, HlyD family C7M19_RS15685 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M19_RS15690 ENOG4105CS1 NAD(P)H quinone oxidoreductase C7M19_RS15705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS15710 ENOG4105CZV ABC transporter C7M19_RS15715 ENOG4105CJ1 ABC, transporter C7M19_RS15720 ENOG4108TU7 Inherit from COG: (ABC) transporter C7M19_RS15725 ENOG4105VEQ Cold shock protein C7M19_RS15735 ENOG4105BZU Histidine kinase C7M19_RS15775 ENOG4108YBP pseudouridine synthase C7M19_RS15785 ENOG41080XP Cbs domain C7M19_RS15790 ENOG4107YBY Hydrolase C7M19_RS15795 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M19_RS15800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M19_RS15805 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C7M19_RS15815 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C7M19_RS15820 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C7M19_RS15830 ENOG4105BZU Histidine kinase C7M19_RS15835 ENOG4105WH1 Two component transcriptional regulator luxr family C7M19_RS15870 ENOG4105ED1 spovr family C7M19_RS15875 ENOG4105G6Z alkaline phosphatase C7M19_RS15890 ENOG4105BZN citrate synthase C7M19_RS15895 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M19_RS15900 ENOG4105CUB amino acid C7M19_RS15905 ENOG4105C8J )-transporter C7M19_RS15915 ENOG4105J37 C7M19_RS15920 ENOG4108AEY RNA polymerase sigma factor C7M19_RS15925 ENOG4105F6E Acyl-transferase C7M19_RS15930 ENOG4105C37 (CBS) domain C7M19_RS15940 ENOG4105CHM Aminotransferase C7M19_RS15945 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C7M19_RS15950 ENOG4105C37 (CBS) domain C7M19_RS15960 ENOG4105WMR Protein CrcB homolog C7M19_RS15965 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M19_RS15975 ENOG4105D64 Mechanosensitive ion channel C7M19_RS15980 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C7M19_RS15985 ENOG4107VMI polysaccharide deacetylase C7M19_RS15990 ENOG4105F0I Aminotransferase C7M19_RS15995 ENOG4105W1N transcriptional regulator C7M19_RS16000 ENOG4105IIP Membrane C7M19_RS16010 ENOG4105BZ1 (ABC) transporter C7M19_RS16015 ENOG4105BZ1 (ABC) transporter C7M19_RS16035 ENOG410839P C7M19_RS16045 ENOG4106MP8 UPF0754 membrane protein C7M19_RS16050 ENOG4105WZB UPF0342 protein C7M19_RS16055 ENOG4105F1N DNA alkylation repair C7M19_RS16065 ENOG4105D4P Coproporphyrinogen iii oxidase C7M19_RS16075 ENOG4107S91 Sodium hydrogen exchanger C7M19_RS16080 ENOG4105NCW Trka-c domain protein C7M19_RS16090 ENOG4105CGU Enoyl-CoA hydratase C7M19_RS16100 ENOG4108IUX (ABC) transporter C7M19_RS16105 ENOG4105RHA ABC transporter, permease C7M19_RS16110 ENOG4107VRP DNA repair exonuclease C7M19_RS16115 ENOG4106D4I domain protein C7M19_RS16120 ENOG4105EQI Metal Dependent Phosphohydrolase C7M19_RS16130 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C7M19_RS16175 ENOG4105NBU tryptophan transport protein C7M19_RS16180 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C7M19_RS16185 ENOG4105K59 histidine triad (HIT) protein C7M19_RS16215 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C7M19_RS16220 ENOG4105BZ4 penicillin-binding protein C7M19_RS16225 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C7M19_RS16230 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C7M19_RS16235 ENOG4105C1Q protoporphyrinogen oxidase C7M19_RS16245 ENOG4105ECB domain protein C7M19_RS16260 ENOG4105DER m42 family C7M19_RS16270 ENOG4106AXD C7M19_RS16275 ENOG4108RQ5 Beta-lactamase domain-containing protein C7M19_RS16280 ENOG4105DF9 Lipoate-protein, ligase C7M19_RS16290 ENOG4105CEY Amp-dependent synthetase and ligase C7M19_RS16300 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C7M19_RS16315 ENOG4108HUF Transporter C7M19_RS16320 ENOG4107TB6 phosphoglycerate mutase C7M19_RS16330 ENOG4107F3J Amp-dependent synthetase and ligase C7M19_RS16335 ENOG4107ZYJ bioY protein C7M19_RS16340 ENOG4106YBV Methyl-accepting chemotaxis C7M19_RS16360 ENOG4105XVF Competence transcription factor C7M19_RS16370 ENOG4108ZMX Domain of unknown function (DU1801) C7M19_RS16385 ENOG4105X3H Excalibur domain protein C7M19_RS16390 ENOG4105K8R UPF0145 protein C7M19_RS16395 ENOG4105E1V na solute symporter C7M19_RS16400 ENOG4106CAD Protein of unknown function (DUF3311) C7M19_RS16405 ENOG41060YP C7M19_RS16420 ENOG4107SCK Monooxygenase C7M19_RS16425 ENOG4108INS Transcriptional regulator C7M19_RS16430 ENOG4108KK1 membrane protein AbrB duplication C7M19_RS16440 ENOG4108IG5 Transcriptional regulator C7M19_RS16450 ENOG4108QY0 Membrane C7M19_RS16455 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination C7M19_RS16460 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C7M19_RS16470 ENOG4105EYH Exonuclease C7M19_RS16515 ENOG4105ERH Fumarylacetoacetate hydrolase C7M19_RS16530 ENOG4105CAQ asparagine synthetase C7M19_RS16540 ENOG4105UQX Mate efflux family protein C7M19_RS16545 ENOG4106HBX Transcriptional Regulator AraC Family C7M19_RS16550 ENOG4105SF0 DinB family C7M19_RS16555 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C7M19_RS16560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M19_RS16565 ENOG4105MYW Pentapeptide repeat protein C7M19_RS16570 ENOG4105MA6 gCN5-related N-acetyltransferase C7M19_RS16580 ENOG4108VPT UPF0234 protein C7M19_RS16585 ENOG4105QNR S1 RNA binding domain protein C7M19_RS16590 ENOG4105DIH basic membrane C7M19_RS16595 ENOG4105C8Q Methyl-accepting chemotaxis C7M19_RS16600 ENOG4107E6A Cytochrome p-450 C7M19_RS16610 ENOG4105EPR degv family C7M19_RS16615 ENOG4107AYK membrAne C7M19_RS16625 ENOG41073B9 C7M19_RS16630 ENOG4108KP7 hydrolase C7M19_RS16635 ENOG4108MXZ Esterase C7M19_RS16640 ENOG4105VG1 fes assembly suf system protein C7M19_RS16645 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C7M19_RS16650 ENOG4105IQ5 FAD linked oxidase domain protein C7M19_RS16660 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C7M19_RS16670 ENOG4105CAS nag kinase C7M19_RS16675 ENOG4105C8Y Acetylornithine aminotransferase C7M19_RS16680 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M19_RS16690 ENOG4105DBV ornithine carbamoyltransferase C7M19_RS16715 ENOG4107RMD Basic membrane lipoprotein C7M19_RS16730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C7M19_RS16735 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C7M19_RS16745 ENOG4105C3U ABC transporter C7M19_RS16750 ENOG4108JQ7 (ABC) transporter C7M19_RS16765 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M19_RS16775 ENOG4105C31 Tryptophanyl-tRNA synthetase C7M19_RS16780 ENOG4108J59 Extracellular solute-binding protein, family 5 C7M19_RS16785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M19_RS16790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M19_RS16800 ENOG4108JQ7 (ABC) transporter C7M19_RS16815 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C7M19_RS16820 ENOG4108ZCF integral membrane protein C7M19_RS16825 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C7M19_RS16835 ENOG4105DPN Oligoendopeptidase f C7M19_RS16840 ENOG4105T58 Dithiol-disulfide isomerase C7M19_RS16845 ENOG4108Z18 K06886 hemoglobin C7M19_RS16850 ENOG4105E4C Lytic transglycosylase catalytic C7M19_RS16855 ENOG4105MIX Adenylate cyclase C7M19_RS16870 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M19_RS16875 ENOG4105EMS pseudouridine synthase C7M19_RS16880 ENOG4107S1Q Phosphatase C7M19_RS16890 ENOG4105ETU transcriptional activator (TenA C7M19_RS16895 ENOG4108VEU Thiamine monophosphate synthase C7M19_RS16915 ENOG4105D06 uba thif-type nad fad binding protein C7M19_RS16920 ENOG4105DWF phosphomethylpyrimidine kinase C7M19_RS16925 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C7M19_RS16930 ENOG4107A88 C7M19_RS16980 ENOG4105ENA helicase C7M19_RS17000 ENOG4105CJ1 ABC, transporter C7M19_RS17015 ENOG4108ZMI UPF0477 protein C7M19_RS17025 ENOG4105C28 cystathionine C7M19_RS17030 ENOG4105C28 cystathionine C7M19_RS17050 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M19_RS17180 ENOG4106BHF C7M19_RS17190 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C7M19_RS17220 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase C7M19_RS17225 ENOG4105CMR udp-glucose 4-epimerase C7M19_RS17230 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C7M19_RS17235 ENOG4105CK1 PTS System C7M19_RS17240 ENOG4105VCP PTS System C7M19_RS17270 ENOG4105KT7 mgtC SapB transporter C7M19_RS17295 ENOG4108IEG Formate dehydrogenase Alpha subunit C7M19_RS17305 ENOG4106A3M Cytochrome p-450 C7M19_RS17310 ENOG41087PP glycosyltransferase MGT family C7M19_RS17320 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C7M19_RS17325 ENOG4105C4B ABC transporter, permease C7M19_RS17330 ENOG4108IXI (ABC) transporter C7M19_RS17340 ENOG4105Q95 Cupin 2, conserved barrel domain protein C7M19_RS17355 ENOG4105D2H Uronic isomerase C7M19_RS17360 ENOG4105CT4 transporter C7M19_RS17365 ENOG4107KJX Transcriptional regulator C7M19_RS17370 ENOG4107QZW Altronate oxidoreductase C7M19_RS17375 ENOG4105CTX dehydratase C7M19_RS17380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M19_RS17385 ENOG4105F3H Histidine kinase C7M19_RS17405 ENOG4107TSN permease C7M19_RS17425 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M19_RS17430 ENOG4105KWG Pfam:DUF1696 C7M19_RS17435 ENOG4105K7W phage-related replication protein C7M19_RS17440 ENOG410635T phage-like element pbsx protein C7M19_RS17480 ENOG4108TFU terminase (Small subunit) C7M19_RS17485 ENOG4105IG6 Phage terminase, large subunit C7M19_RS17490 ENOG4108MDF Phage Portal Protein C7M19_RS17515 ENOG41060SN C7M19_RS17530 ENOG4105PQS phage protein C7M19_RS17535 ENOG4105FR7 XkdM protein, phage-like element PBSX C7M19_RS17540 ENOG4105MTC XkdN-like protein C7M19_RS17550 ENOG4108FKH Transglycosylase SLT domain C7M19_RS17550 ENOG4108FKH Transglycosylase SLT domain C7M19_RS17550 ENOG4108FKH Transglycosylase SLT domain C7M19_RS17555 ENOG4108WZM domain protein C7M19_RS17560 ENOG4105X7F C7M19_RS17570 ENOG4105MFU Protein of unknown function (DUF2634) C7M19_RS17575 ENOG41066EA baseplate J family protein C7M19_RS17580 ENOG410906S phage-like element pbsx protein xkdt C7M19_RS17590 ENOG41068G1 C7M19_RS17620 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M19_RS17635 ENOG4105CJ3 phosphate transporter C7M19_RS17640 ENOG4107GRR phosphate transport regulator C7M19_RS17645 ENOG4107R7I amino acid C7M19_RS17655 ENOG4105EDW glycosyl transferase, family 39 C7M19_RS17660 ENOG4105CKK Glycosyl transferase, family 2 C7M19_RS17665 ENOG4105C0H protease C7M19_RS17675 ENOG4108ME1 Peptidase M55 D-aminopeptidase C7M19_RS17680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M19_RS17685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M19_RS17690 ENOG4105C3U ABC transporter C7M19_RS17700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C7M19_RS17705 ENOG4105DTQ mandelate racemase muconate lactonizing C7M19_RS17710 ENOG4107SN7 NLP P60 protein C7M19_RS17715 ENOG4108JQ7 (ABC) transporter C7M19_RS17720 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C7M19_RS17725 ENOG4107TUM Amidinotransferase C7M19_RS17730 ENOG4108S4H thioesterase Superfamily protein C7M19_RS17735 ENOG4108428 Inherit from COG: -acetyltransferase C7M19_RS17745 ENOG41080TC multidrug resistance protein C7M19_RS17750 ENOG4105CIY formyltetrahydrofolate deformylase C7M19_RS17755 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M19_RS17770 ENOG4105K56 Transcriptional regulator C7M19_RS17775 ENOG4108ZHJ Organic hydroperoxide resistance protein C7M19_RS17790 ENOG4107TVC Glycosyl transferase, family 2 C7M19_RS17800 ENOG4105D8G Major Facilitator superfamily C7M19_RS17805 ENOG4108Y4K DNA-binding transcriptional activator C7M19_RS17810 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C7M19_RS17815 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M19_RS17825 ENOG4108W7F transporter, permease C7M19_RS17830 ENOG4108JJB ABC transporter C7M19_RS17835 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C7M19_RS17840 ENOG4105VRS hydrolase family 18 C7M19_RS17855 ENOG4105CJW magnesium transporter C7M19_RS17860 ENOG4105V75 Transcriptional regulator C7M19_RS17885 ENOG4105DQE DNA ligase C7M19_RS17890 ENOG4105FDF Could be involved in DNA repair (By similarity) C7M19_RS17895 ENOG4107T5V SNARE associated Golgi C7M19_RS17900 ENOG4107TS3 membrane protein, TerC C7M19_RS17905 ENOG4108WZW RNA polymerase sigma C7M19_RS17915 ENOG410681C small acid-soluble spore protein C7M19_RS17925 ENOG4105D0M Protease HtpX homolog C7M19_RS17940 ENOG410900G Protein of unknown function (DUF421) C7M19_RS17950 ENOG4108TGC Acyltransferase C7M19_RS17955 ENOG4105BZU Histidine kinase C7M19_RS17960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M19_RS17965 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C7M19_RS17975 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M19_RS17985 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate C7M19_RS17990 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C7M19_RS17995 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C7M19_RS18000 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C7M19_RS18010 ENOG4105BZU Histidine kinase C7M19_RS18015 ENOG41090MY MarR family Transcriptional regulator C7M19_RS18020 ENOG4105ER2 Ompa motb domain protein C7M19_RS18025 ENOG4105E14 MotA TolQ exbB proton channel C7M19_RS18035 ENOG4108K88 Membrane C7M19_RS18045 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C7M19_RS18050 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C7M19_RS18055 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C7M19_RS18060 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C7M19_RS18070 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C7M19_RS18095 ENOG4105F0V Cell wall hydrolase C7M19_RS18110 ENOG4105C59 p-type ATPase C7M19_RS18115 ENOG4105DC7 peptidase M24 C7M19_RS18125 ENOG4105CID antiterminator C7M19_RS18135 ENOG4105KRI phosphocarrier protein (HPr C7M19_RS18140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C7M19_RS18150 ENOG4105F6S Spore photoproduct lyase C7M19_RS18155 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C7M19_RS18160 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C7M19_RS18165 ENOG4105K4I Scp-like extracellular C7M19_RS18175 ENOG4105BZU Histidine kinase C7M19_RS18180 ENOG4105CHM Aminotransferase C7M19_RS18185 ENOG4107R88 Chemotaxis protein (CheV) C7M19_RS18190 ENOG4105UIN C7M19_RS18200 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C7M19_RS18210 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C7M19_RS18220 ENOG4105EPM Diguanylate phosphodiesterase C7M19_RS18225 ENOG4107IN1 Protein of unknown function (DUF1797) C7M19_RS18230 ENOG4108XRC Protein of unknown function (DUF458) C7M19_RS18260 ENOG4105NQC Flavodoxin C7M19_RS18280 ENOG4105D8X mechanosensitive ion channel C7M19_RS18285 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M19_RS18300 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C7M19_RS18305 ENOG4105D06 uba thif-type nad fad binding protein C7M19_RS18310 ENOG4105CVM Molybdenum cofactor synthesis domain protein C7M19_RS18315 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C7M19_RS18320 ENOG4108ZAF Molybdopterin C7M19_RS18325 ENOG41067WU Molybdopterin converting factor (Subunit 1) C7M19_RS18335 ENOG4107X8C Efflux transporter RND family MFP subunit C7M19_RS18340 ENOG4105C19 ABC transporter C7M19_RS18345 ENOG4107RBB ABC transporter, permease C7M19_RS18350 ENOG4105E98 transcriptional regulator DeoR family C7M19_RS18355 ENOG4105DE4 1-phosphofructokinase C7M19_RS18360 ENOG4105DM4 PTS System C7M19_RS18375 ENOG4105C5H ABC transporter C7M19_RS18380 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C7M19_RS18405 ENOG4105BZU Histidine kinase C7M19_RS18415 ENOG4107ZYR domain protein C7M19_RS18420 ENOG4105CPN adenine deaminase C7M19_RS18425 ENOG4105CN5 Metallo-Beta-Lactamase C7M19_RS18430 ENOG4106148 UPF0356 protein C7M19_RS18435 ENOG4108X4Q Hydrolase C7M19_RS18440 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M19_RS18455 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M19_RS18460 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS18465 ENOG4107SQU synthase C7M19_RS18470 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS18475 ENOG4107SQU synthase C7M19_RS18480 ENOG4107SQU synthase C7M19_RS18485 ENOG4107SQU synthase C7M19_RS18490 ENOG4105C0W non-ribosomal peptide synthetase C7M19_RS18495 ENOG4105FQP Beta-lactamase C7M19_RS18505 ENOG4105CPP Dehydrogenase, E1 component C7M19_RS18510 ENOG4105C7S Dehydrogenase C7M19_RS18515 ENOG4107QN2 dihydrolipoyl dehydrogenase C7M19_RS18535 ENOG4105CXN decarboxylase C7M19_RS18540 ENOG4105WBI UPF0223 protein C7M19_RS18555 ENOG4105ECY inositol monophosphatase C7M19_RS18565 ENOG4105D4Y metalloprotease C7M19_RS18590 ENOG4105CI3 gtp-binding protein typa C7M19_RS18595 ENOG4105QA2 C7M19_RS18610 ENOG4108IAB Phoh family C7M19_RS18620 ENOG4105CSV Glutaminase C7M19_RS18630 ENOG4105CNI cell division protein FtsW C7M19_RS18635 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C7M19_RS18645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M19_RS18655 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M19_RS18660 ENOG4105CCU oxidase (Subunit III) C7M19_RS18665 ENOG41064X9 cytochrome C oxidase subunit IV C7M19_RS18680 ENOG41080XQ Signal transduction protein with cbs domains C7M19_RS18685 ENOG4106UY4 Inherit from COG: Scp-like extracellular C7M19_RS18710 ENOG4106H78 methyltransferase C7M19_RS18715 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C7M19_RS18720 ENOG4105H20 Sporulation integral membrane protein YlbJ C7M19_RS18725 ENOG4105D78 K07001 NTE family protein C7M19_RS18730 ENOG41063PX domain protein C7M19_RS18735 ENOG4105CDE UPF0348 protein C7M19_RS18740 ENOG4105KNH Nucleic acid-binding protein C7M19_RS18745 ENOG41067VY 50S ribosomal protein L32 C7M19_RS18770 ENOG4108V6E Cell division protein mraZ C7M19_RS18775 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C7M19_RS18785 ENOG4105CJN penicillin-binding protein C7M19_RS18790 ENOG4105CJN penicillin-binding protein C7M19_RS18795 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C7M19_RS18800 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C7M19_RS18805 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C7M19_RS18810 ENOG4105CNI cell division protein FtsW C7M19_RS18815 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C7M19_RS18820 ENOG4105D4A Cell wall formation (By similarity) C7M19_RS18825 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C7M19_RS18830 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C7M19_RS18835 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C7M19_RS18845 ENOG4105FFI sigma-e processing peptidase spoiiga C7M19_RS18850 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS18860 ENOG4105DKW ABC transporter C7M19_RS18870 ENOG4105WR5 sporulation protein, YlmC YmxH family C7M19_RS18875 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C7M19_RS18880 ENOG4105DFA alanine racemase domain protein C7M19_RS18885 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C7M19_RS18890 ENOG41067XK integral membrane protein C7M19_RS18895 ENOG4105DBK s4 domain protein C7M19_RS18905 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C7M19_RS18915 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C7M19_RS18920 ENOG4105C34 Pseudouridine synthase C7M19_RS18925 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C7M19_RS18935 ENOG4105CXT aspartate transcarbamylase C7M19_RS18945 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M19_RS18950 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C7M19_RS18955 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C7M19_RS18960 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C7M19_RS18965 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C7M19_RS18970 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C7M19_RS18985 ENOG4107RIQ Sulfate adenylate transferase C7M19_RS18995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M19_RS19000 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C7M19_RS19005 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C7M19_RS19010 ENOG4105F23 Fibronectin-binding protein C7M19_RS19020 ENOG4105DSJ YicC domain protein C7M19_RS19025 ENOG4105KC4 UPF0296 protein C7M19_RS19030 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C7M19_RS19040 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C7M19_RS19045 ENOG4105C25 Primosomal protein n' C7M19_RS19050 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M19_RS19055 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C7M19_RS19060 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C7M19_RS19065 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C7M19_RS19070 ENOG4108ZF3 Phosphatase C7M19_RS19075 ENOG4105D9P serine threonine protein kinase C7M19_RS19080 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C7M19_RS19085 ENOG4105DJV ribulose-phosphate 3-epimerase C7M19_RS19090 ENOG4105FJ0 thiamine C7M19_RS19100 ENOG4105VB9 50S ribosomal protein l28 C7M19_RS19105 ENOG4108ZAA Alkaline-shock protein C7M19_RS19110 ENOG4105DP4 dak2 domain fusion protein ylov C7M19_RS19120 ENOG4105EJQ L-serine dehydratase C7M19_RS19125 ENOG4105CB5 ATP-dependent DNA helicase recG C7M19_RS19130 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C7M19_RS19135 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C7M19_RS19140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M19_RS19145 ENOG4105CHR reductase C7M19_RS19150 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C7M19_RS19155 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C7M19_RS19160 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C7M19_RS19165 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C7M19_RS19175 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C7M19_RS19185 ENOG4105K5M 30s ribosomal protein S16 C7M19_RS19190 ENOG4108BW8 UPF0109 protein C7M19_RS19205 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C7M19_RS19210 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C7M19_RS19215 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C7M19_RS19220 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M19_RS19230 ENOG4105VM1 flagellar C7M19_RS19235 ENOG4105CMV Succinyl-CoA synthetase subunit beta C7M19_RS19240 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C7M19_RS19245 ENOG4105C79 DNA protecting protein DprA C7M19_RS19250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C7M19_RS19255 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C7M19_RS19260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M19_RS19265 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C7M19_RS19270 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C7M19_RS19280 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C7M19_RS19285 ENOG4108ZC9 flagellar basal-body rod protein flgc C7M19_RS19290 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C7M19_RS19295 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C7M19_RS19300 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M19_RS19315 ENOG4106YF4 Flagellar biosynthesis chaperone C7M19_RS19325 ENOG410696Y Flagellar hook-length control protein C7M19_RS19330 ENOG410822I Flagellar hook capping protein C7M19_RS19335 ENOG4108JQA flagellar C7M19_RS19340 ENOG41068WV flagellar FlbD family protein C7M19_RS19350 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M19_RS19355 ENOG4105DD5 Flagellar motor switch protein C7M19_RS19360 ENOG4107YTP response regulator receiver protein C7M19_RS19370 ENOG4105CN7 Flagellar biosynthetic protein FliP C7M19_RS19375 ENOG4105VS8 Flagellar biosynthetic protein fliq C7M19_RS19380 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C7M19_RS19385 ENOG4105D00 flagellar biosynthetic protein flhB C7M19_RS19390 ENOG4105D7B Flagellar biosynthesis protein flha C7M19_RS19395 ENOG4105FZW flagellar biosynthesis regulator FlhF C7M19_RS19405 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C7M19_RS19410 ENOG4105CBS Chea signal transduction histidine kinase C7M19_RS19415 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C7M19_RS19425 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) C7M19_RS19430 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M19_RS19440 ENOG4105CE9 30S ribosomal protein S2 C7M19_RS19450 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C7M19_RS19455 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C7M19_RS19460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C7M19_RS19465 ENOG4105KNE Phosphatidate cytidylyltransferase C7M19_RS19475 ENOG4105DZP Membrane-associated zinc metalloprotease C7M19_RS19480 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C7M19_RS19485 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C7M19_RS19490 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C7M19_RS19495 ENOG4105CHV Transcription elongation factor NusA C7M19_RS19500 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C7M19_RS19505 ENOG4105VHM ribosomal protein C7M19_RS19510 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C7M19_RS19515 ENOG4105W7A Protein of unknown function (DUF503) C7M19_RS19520 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C7M19_RS19525 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C7M19_RS19530 ENOG4105DTN riboflavin biosynthesis protein ribF C7M19_RS19535 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C7M19_RS19540 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C7M19_RS19550 ENOG4105C1V Peptidase, M16 C7M19_RS19560 ENOG4105E35 Dipicolinate synthase subunit A C7M19_RS19565 ENOG4108S0H Dipicolinic acid synthetase, b subunit C7M19_RS19570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C7M19_RS19580 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C7M19_RS19590 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C7M19_RS19600 ENOG4105CNU cell division protein FtsK C7M19_RS19605 ENOG4105FDP GntR family transcriptional regulator C7M19_RS19620 ENOG4105EYF MMPL domain protein C7M19_RS19635 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C7M19_RS19640 ENOG4105XZV Protein of unknown function (DUF3243) C7M19_RS19655 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C7M19_RS19660 ENOG4105CEV competence damage-inducible protein C7M19_RS19665 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C7M19_RS19670 ENOG4108A04 Beta-lactamase C7M19_RS19680 ENOG4105D48 metallophosphoesterase C7M19_RS19685 ENOG4105MCT stage V sporulation protein S C7M19_RS19690 ENOG4105CPQ Dehydrogenase C7M19_RS19695 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M19_RS19700 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M19_RS19720 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C7M19_RS19730 ENOG4108151 Beta-lactamase domain protein C7M19_RS19735 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M19_RS19740 ENOG4108JA1 polyketide synthase C7M19_RS19745 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M19_RS19750 ENOG41062T2 Acyl carrier protein C7M19_RS19755 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C7M19_RS19760 ENOG4108MGH Enoyl-CoA hydratase C7M19_RS19765 ENOG4108KQ6 Enoyl-CoA hydratase