locus-tag class description DBK22_RS00010 ENOG4107NBY Membrane DBK22_RS00015 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DBK22_RS00020 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DBK22_RS00025 ENOG4105G5W regulator Fur family DBK22_RS00030 ENOG4105TUA UPF0295 protein DBK22_RS00135 ENOG4107S6Z Na H antiporter DBK22_RS00140 ENOG4105EC3 peptidase S51, dipeptidase E DBK22_RS00145 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DBK22_RS00150 ENOG4105DNP FAD linked oxidase domain protein DBK22_RS00160 ENOG4105DEF Extracellular solute-binding protein, family 5 DBK22_RS00170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DBK22_RS00175 ENOG4105C3U ABC transporter DBK22_RS00180 ENOG4108JQ7 (ABC) transporter DBK22_RS00195 ENOG4105E2Y ABC, transporter DBK22_RS00200 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DBK22_RS00205 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DBK22_RS00215 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DBK22_RS00220 ENOG4107D63 DBK22_RS00225 ENOG4105VZ8 Transcriptional regulator DBK22_RS00240 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DBK22_RS00250 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DBK22_RS00270 ENOG4105CYN Serine protein kinase DBK22_RS00280 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DBK22_RS00285 ENOG4105CW7 secretion protein, HlyD family DBK22_RS00290 ENOG4105C0R drug resistance transporter emrb qaca subfamily DBK22_RS00295 ENOG4105CS1 NAD(P)H quinone oxidoreductase DBK22_RS00310 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS00315 ENOG4105CZV ABC transporter DBK22_RS00320 ENOG4105CJ1 ABC, transporter DBK22_RS00325 ENOG4108TU7 Inherit from COG: (ABC) transporter DBK22_RS00330 ENOG4105VEQ Cold shock protein DBK22_RS00340 ENOG4105BZU Histidine kinase DBK22_RS00380 ENOG4108YBP pseudouridine synthase DBK22_RS00390 ENOG41080XP Cbs domain DBK22_RS00395 ENOG4107YBY Hydrolase DBK22_RS00400 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DBK22_RS00405 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DBK22_RS00410 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DBK22_RS00420 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DBK22_RS00425 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DBK22_RS00435 ENOG4105BZU Histidine kinase DBK22_RS00440 ENOG4105WH1 Two component transcriptional regulator luxr family DBK22_RS00475 ENOG4105ED1 spovr family DBK22_RS00480 ENOG4105G6Z alkaline phosphatase DBK22_RS00495 ENOG4105BZN citrate synthase DBK22_RS00500 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DBK22_RS00505 ENOG4105CUB amino acid DBK22_RS00510 ENOG4105C8J )-transporter DBK22_RS00520 ENOG4105J37 DBK22_RS00525 ENOG4108AEY RNA polymerase sigma factor DBK22_RS00530 ENOG4105F6E Acyl-transferase DBK22_RS00535 ENOG4105C37 (CBS) domain DBK22_RS00545 ENOG4105CHM Aminotransferase DBK22_RS00550 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DBK22_RS00555 ENOG4105C37 (CBS) domain DBK22_RS00565 ENOG4105WMR Protein CrcB homolog DBK22_RS00570 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DBK22_RS00580 ENOG4105D64 Mechanosensitive ion channel DBK22_RS00585 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DBK22_RS00590 ENOG4107VMI polysaccharide deacetylase DBK22_RS00595 ENOG4105F0I Aminotransferase DBK22_RS00600 ENOG4105W1N transcriptional regulator DBK22_RS00605 ENOG4105IIP Membrane DBK22_RS00615 ENOG4105BZ1 (ABC) transporter DBK22_RS00620 ENOG4105BZ1 (ABC) transporter DBK22_RS00640 ENOG410839P DBK22_RS00650 ENOG4106MP8 UPF0754 membrane protein DBK22_RS00655 ENOG4105WZB UPF0342 protein DBK22_RS00660 ENOG4105F1N DNA alkylation repair DBK22_RS00670 ENOG4105D4P Coproporphyrinogen iii oxidase DBK22_RS00680 ENOG4107S91 Sodium hydrogen exchanger DBK22_RS00685 ENOG4105NCW Trka-c domain protein DBK22_RS00695 ENOG4105CGU Enoyl-CoA hydratase DBK22_RS00705 ENOG4108IUX (ABC) transporter DBK22_RS00710 ENOG4105RHA ABC transporter, permease DBK22_RS00715 ENOG4107VRP DNA repair exonuclease DBK22_RS00720 ENOG4106D4I domain protein DBK22_RS00725 ENOG4105EQI Metal Dependent Phosphohydrolase DBK22_RS00735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DBK22_RS00780 ENOG4105NBU tryptophan transport protein DBK22_RS00785 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DBK22_RS00790 ENOG4105K59 histidine triad (HIT) protein DBK22_RS00820 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DBK22_RS00825 ENOG4105BZ4 penicillin-binding protein DBK22_RS00830 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DBK22_RS00835 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DBK22_RS00840 ENOG4105C1Q protoporphyrinogen oxidase DBK22_RS00850 ENOG4105ECB domain protein DBK22_RS00865 ENOG4105DER m42 family DBK22_RS00875 ENOG4106AXD DBK22_RS00880 ENOG4108RQ5 Beta-lactamase domain-containing protein DBK22_RS00885 ENOG4105DF9 Lipoate-protein, ligase DBK22_RS00895 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS00905 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DBK22_RS00920 ENOG4108HUF Transporter DBK22_RS00925 ENOG4107TB6 phosphoglycerate mutase DBK22_RS00935 ENOG4107F3J Amp-dependent synthetase and ligase DBK22_RS00940 ENOG4107ZYJ bioY protein DBK22_RS00945 ENOG4106YBV Methyl-accepting chemotaxis DBK22_RS00965 ENOG4105XVF Competence transcription factor DBK22_RS00975 ENOG4108ZMX Domain of unknown function (DU1801) DBK22_RS00990 ENOG4105X3H Excalibur domain protein DBK22_RS00995 ENOG4105K8R UPF0145 protein DBK22_RS01000 ENOG4105E1V na solute symporter DBK22_RS01005 ENOG4106CAD Protein of unknown function (DUF3311) DBK22_RS01010 ENOG41060YP DBK22_RS01025 ENOG4107SCK Monooxygenase DBK22_RS01030 ENOG4108INS Transcriptional regulator DBK22_RS01035 ENOG4108KK1 membrane protein AbrB duplication DBK22_RS01045 ENOG4108IG5 Transcriptional regulator DBK22_RS01055 ENOG4108QY0 Membrane DBK22_RS01060 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DBK22_RS01065 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DBK22_RS01075 ENOG4105EYH Exonuclease DBK22_RS01120 ENOG4105ERH Fumarylacetoacetate hydrolase DBK22_RS01140 ENOG4105CAQ asparagine synthetase DBK22_RS01150 ENOG4105UQX Mate efflux family protein DBK22_RS01155 ENOG4106HBX Transcriptional Regulator AraC Family DBK22_RS01160 ENOG4105SF0 DinB family DBK22_RS01165 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DBK22_RS01170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS01175 ENOG4105MYW Pentapeptide repeat protein DBK22_RS01180 ENOG4105MA6 gCN5-related N-acetyltransferase DBK22_RS01190 ENOG4108VPT UPF0234 protein DBK22_RS01195 ENOG4105QNR S1 RNA binding domain protein DBK22_RS01200 ENOG4105DIH basic membrane DBK22_RS01205 ENOG4105C8Q Methyl-accepting chemotaxis DBK22_RS01210 ENOG4107E6A Cytochrome p-450 DBK22_RS01220 ENOG4105EPR degv family DBK22_RS01225 ENOG4107AYK membrAne DBK22_RS01235 ENOG41073B9 DBK22_RS01240 ENOG4108KP7 hydrolase DBK22_RS01245 ENOG4108MXZ Esterase DBK22_RS01250 ENOG4105VG1 fes assembly suf system protein DBK22_RS01255 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DBK22_RS01260 ENOG4105IQ5 FAD linked oxidase domain protein DBK22_RS01270 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DBK22_RS01280 ENOG4105CAS nag kinase DBK22_RS01285 ENOG4105C8Y Acetylornithine aminotransferase DBK22_RS01290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DBK22_RS01300 ENOG4105DBV ornithine carbamoyltransferase DBK22_RS01325 ENOG4107RMD Basic membrane lipoprotein DBK22_RS01340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DBK22_RS01345 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DBK22_RS01355 ENOG4105C3U ABC transporter DBK22_RS01360 ENOG4108JQ7 (ABC) transporter DBK22_RS01375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DBK22_RS01385 ENOG4105C31 Tryptophanyl-tRNA synthetase DBK22_RS01390 ENOG4108J59 Extracellular solute-binding protein, family 5 DBK22_RS01395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DBK22_RS01400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DBK22_RS01410 ENOG4108JQ7 (ABC) transporter DBK22_RS01425 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DBK22_RS01430 ENOG4108ZCF integral membrane protein DBK22_RS01435 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DBK22_RS01445 ENOG4105DPN Oligoendopeptidase f DBK22_RS01450 ENOG4105T58 Dithiol-disulfide isomerase DBK22_RS01455 ENOG4108Z18 K06886 hemoglobin DBK22_RS01460 ENOG4105E4C Lytic transglycosylase catalytic DBK22_RS01465 ENOG4105MIX Adenylate cyclase DBK22_RS01480 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DBK22_RS01485 ENOG4105EMS pseudouridine synthase DBK22_RS01490 ENOG4107S1Q Phosphatase DBK22_RS01500 ENOG4105ETU transcriptional activator (TenA DBK22_RS01505 ENOG4108VEU Thiamine monophosphate synthase DBK22_RS01525 ENOG4105D06 uba thif-type nad fad binding protein DBK22_RS01530 ENOG4105DWF phosphomethylpyrimidine kinase DBK22_RS01535 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DBK22_RS01540 ENOG4107A88 DBK22_RS01590 ENOG4105ENA helicase DBK22_RS01610 ENOG4105CJ1 ABC, transporter DBK22_RS01625 ENOG4108ZMI UPF0477 protein DBK22_RS01635 ENOG4105C28 cystathionine DBK22_RS01640 ENOG4105C28 cystathionine DBK22_RS01690 ENOG410907G DBK22_RS01700 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DBK22_RS01730 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase DBK22_RS01735 ENOG4105CMR udp-glucose 4-epimerase DBK22_RS01740 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DBK22_RS01745 ENOG4105CK1 PTS System DBK22_RS01750 ENOG4105VCP PTS System DBK22_RS01780 ENOG4105KT7 mgtC SapB transporter DBK22_RS01805 ENOG4108IEG Formate dehydrogenase Alpha subunit DBK22_RS01815 ENOG4106A3M Cytochrome p-450 DBK22_RS01820 ENOG41087PP glycosyltransferase MGT family DBK22_RS01830 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DBK22_RS01835 ENOG4105C4B ABC transporter, permease DBK22_RS01840 ENOG4108IXI (ABC) transporter DBK22_RS01850 ENOG4105Q95 Cupin 2, conserved barrel domain protein DBK22_RS01865 ENOG4105D2H Uronic isomerase DBK22_RS01870 ENOG4105CT4 transporter DBK22_RS01875 ENOG4107KJX Transcriptional regulator DBK22_RS01880 ENOG4107QZW Altronate oxidoreductase DBK22_RS01885 ENOG4105CTX dehydratase DBK22_RS01890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS01895 ENOG4105F3H Histidine kinase DBK22_RS01915 ENOG4107TSN permease DBK22_RS01935 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DBK22_RS01940 ENOG4105KWG Pfam:DUF1696 DBK22_RS01945 ENOG4105K7W phage-related replication protein DBK22_RS01950 ENOG410635T phage-like element pbsx protein DBK22_RS01990 ENOG4108TFU terminase (Small subunit) DBK22_RS01995 ENOG4105IG6 Phage terminase, large subunit DBK22_RS02000 ENOG4108MDF Phage Portal Protein DBK22_RS02025 ENOG41060SN DBK22_RS02040 ENOG4105PQS phage protein DBK22_RS02045 ENOG4105FR7 XkdM protein, phage-like element PBSX DBK22_RS02050 ENOG4105MTC XkdN-like protein DBK22_RS02060 ENOG4108FKH Transglycosylase SLT domain DBK22_RS02065 ENOG4108WZM domain protein DBK22_RS02070 ENOG4105X7F DBK22_RS02080 ENOG4105MFU Protein of unknown function (DUF2634) DBK22_RS02085 ENOG41066EA baseplate J family protein DBK22_RS02090 ENOG410906S phage-like element pbsx protein xkdt DBK22_RS02100 ENOG41068G1 DBK22_RS02130 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DBK22_RS02145 ENOG4105CJ3 phosphate transporter DBK22_RS02150 ENOG4107GRR phosphate transport regulator DBK22_RS02155 ENOG4107R7I amino acid DBK22_RS02165 ENOG4105EDW glycosyl transferase, family 39 DBK22_RS02170 ENOG4105CKK Glycosyl transferase, family 2 DBK22_RS02175 ENOG4105C0H protease DBK22_RS02185 ENOG4108ME1 Peptidase M55 D-aminopeptidase DBK22_RS02190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DBK22_RS02195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DBK22_RS02200 ENOG4105C3U ABC transporter DBK22_RS02210 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DBK22_RS02215 ENOG4105DTQ mandelate racemase muconate lactonizing DBK22_RS02220 ENOG4107SN7 NLP P60 protein DBK22_RS02225 ENOG4108JQ7 (ABC) transporter DBK22_RS02230 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DBK22_RS02235 ENOG4107TUM Amidinotransferase DBK22_RS02240 ENOG4108S4H thioesterase Superfamily protein DBK22_RS02245 ENOG4108428 Inherit from COG: -acetyltransferase DBK22_RS02255 ENOG41080TC multidrug resistance protein DBK22_RS02260 ENOG4105CIY formyltetrahydrofolate deformylase DBK22_RS02265 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DBK22_RS02280 ENOG4105K56 Transcriptional regulator DBK22_RS02285 ENOG4108ZHJ Organic hydroperoxide resistance protein DBK22_RS02300 ENOG4107TVC Glycosyl transferase, family 2 DBK22_RS02310 ENOG4105D8G Major Facilitator superfamily DBK22_RS02315 ENOG4108Y4K DNA-binding transcriptional activator DBK22_RS02320 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DBK22_RS02325 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DBK22_RS02335 ENOG4108W7F transporter, permease DBK22_RS02340 ENOG4108JJB ABC transporter DBK22_RS02345 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DBK22_RS02350 ENOG4105VRS hydrolase family 18 DBK22_RS02365 ENOG4105CJW magnesium transporter DBK22_RS02370 ENOG4105V75 Transcriptional regulator DBK22_RS02395 ENOG4105DQE DNA ligase DBK22_RS02400 ENOG4105FDF Could be involved in DNA repair (By similarity) DBK22_RS02405 ENOG4107T5V SNARE associated Golgi DBK22_RS02410 ENOG4107TS3 membrane protein, TerC DBK22_RS02415 ENOG4108WZW RNA polymerase sigma DBK22_RS02425 ENOG410681C small acid-soluble spore protein DBK22_RS02435 ENOG4105D0M Protease HtpX homolog DBK22_RS02445 ENOG410900G Protein of unknown function (DUF421) DBK22_RS02455 ENOG4108TGC Acyltransferase DBK22_RS02460 ENOG4105BZU Histidine kinase DBK22_RS02465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DBK22_RS02470 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DBK22_RS02480 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DBK22_RS02490 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DBK22_RS02495 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DBK22_RS02500 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DBK22_RS02505 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DBK22_RS02515 ENOG4105BZU Histidine kinase DBK22_RS02520 ENOG41090MY MarR family Transcriptional regulator DBK22_RS02525 ENOG4105ER2 Ompa motb domain protein DBK22_RS02530 ENOG4105E14 MotA TolQ exbB proton channel DBK22_RS02540 ENOG4108K88 Membrane DBK22_RS02550 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DBK22_RS02555 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DBK22_RS02560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DBK22_RS02565 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DBK22_RS02575 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DBK22_RS02600 ENOG4105F0V Cell wall hydrolase DBK22_RS02615 ENOG4105C59 p-type ATPase DBK22_RS02620 ENOG4105DC7 peptidase M24 DBK22_RS02630 ENOG4105CID antiterminator DBK22_RS02640 ENOG4105KRI phosphocarrier protein (HPr DBK22_RS02645 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DBK22_RS02655 ENOG4105F6S Spore photoproduct lyase DBK22_RS02660 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DBK22_RS02665 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DBK22_RS02670 ENOG4105K4I Scp-like extracellular DBK22_RS02680 ENOG4105BZU Histidine kinase DBK22_RS02685 ENOG4105CHM Aminotransferase DBK22_RS02690 ENOG4107R88 Chemotaxis protein (CheV) DBK22_RS02695 ENOG4105UIN DBK22_RS02705 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DBK22_RS02715 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DBK22_RS02725 ENOG4105EPM Diguanylate phosphodiesterase DBK22_RS02730 ENOG4107IN1 Protein of unknown function (DUF1797) DBK22_RS02735 ENOG4108XRC Protein of unknown function (DUF458) DBK22_RS02765 ENOG4105NQC Flavodoxin DBK22_RS02785 ENOG4105D8X mechanosensitive ion channel DBK22_RS02790 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DBK22_RS02805 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DBK22_RS02810 ENOG4105D06 uba thif-type nad fad binding protein DBK22_RS02815 ENOG4105CVM Molybdenum cofactor synthesis domain protein DBK22_RS02820 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DBK22_RS02825 ENOG4108ZAF Molybdopterin DBK22_RS02830 ENOG41067WU Molybdopterin converting factor (Subunit 1) DBK22_RS02840 ENOG4107X8C Efflux transporter RND family MFP subunit DBK22_RS02845 ENOG4105C19 ABC transporter DBK22_RS02850 ENOG4107RBB ABC transporter, permease DBK22_RS02855 ENOG4105E98 transcriptional regulator DeoR family DBK22_RS02860 ENOG4105DE4 1-phosphofructokinase DBK22_RS02865 ENOG4105DM4 PTS System DBK22_RS02880 ENOG4105C5H ABC transporter DBK22_RS02885 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DBK22_RS02910 ENOG4105BZU Histidine kinase DBK22_RS02920 ENOG4107ZYR domain protein DBK22_RS02925 ENOG4105CPN adenine deaminase DBK22_RS02930 ENOG4105CN5 Metallo-Beta-Lactamase DBK22_RS02935 ENOG4106148 UPF0356 protein DBK22_RS02940 ENOG4108X4Q Hydrolase DBK22_RS02945 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DBK22_RS02970 ENOG4105CPP Dehydrogenase, E1 component DBK22_RS02975 ENOG4105C7S Dehydrogenase DBK22_RS02980 ENOG4107QN2 dihydrolipoyl dehydrogenase DBK22_RS03000 ENOG4105CXN decarboxylase DBK22_RS03005 ENOG4105WBI UPF0223 protein DBK22_RS03020 ENOG4105ECY inositol monophosphatase DBK22_RS03030 ENOG4105D4Y metalloprotease DBK22_RS03055 ENOG4105CI3 gtp-binding protein typa DBK22_RS03060 ENOG4105QA2 DBK22_RS03075 ENOG4108IAB Phoh family DBK22_RS03085 ENOG4105CSV Glutaminase DBK22_RS03095 ENOG4105CNI cell division protein FtsW DBK22_RS03100 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DBK22_RS03110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DBK22_RS03120 ENOG4105BZ9 Cytochrome C oxidase, subunit I DBK22_RS03125 ENOG4105CCU oxidase (Subunit III) DBK22_RS03130 ENOG41064X9 cytochrome C oxidase subunit IV DBK22_RS03145 ENOG41080XQ Signal transduction protein with cbs domains DBK22_RS03150 ENOG4106UY4 Inherit from COG: Scp-like extracellular DBK22_RS03180 ENOG4106H78 methyltransferase DBK22_RS03185 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DBK22_RS03190 ENOG4105H20 Sporulation integral membrane protein YlbJ DBK22_RS03195 ENOG4105D78 K07001 NTE family protein DBK22_RS03200 ENOG41063PX domain protein DBK22_RS03205 ENOG4105CDE UPF0348 protein DBK22_RS03210 ENOG4105KNH Nucleic acid-binding protein DBK22_RS03215 ENOG41067VY 50S ribosomal protein L32 DBK22_RS03240 ENOG4108V6E Cell division protein mraZ DBK22_RS03245 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DBK22_RS03255 ENOG4105CJN penicillin-binding protein DBK22_RS03260 ENOG4105CJN penicillin-binding protein DBK22_RS03265 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DBK22_RS03270 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DBK22_RS03275 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DBK22_RS03280 ENOG4105CNI cell division protein FtsW DBK22_RS03285 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DBK22_RS03290 ENOG4105D4A Cell wall formation (By similarity) DBK22_RS03295 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DBK22_RS03300 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DBK22_RS03305 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DBK22_RS03315 ENOG4105FFI sigma-e processing peptidase spoiiga DBK22_RS03320 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS03330 ENOG4105DKW ABC transporter DBK22_RS03340 ENOG4105WR5 sporulation protein, YlmC YmxH family DBK22_RS03345 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DBK22_RS03350 ENOG4105DFA alanine racemase domain protein DBK22_RS03355 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DBK22_RS03360 ENOG41067XK integral membrane protein DBK22_RS03365 ENOG4105DBK s4 domain protein DBK22_RS03375 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DBK22_RS03385 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DBK22_RS03390 ENOG4105C34 Pseudouridine synthase DBK22_RS03395 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DBK22_RS03405 ENOG4105CXT aspartate transcarbamylase DBK22_RS03415 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DBK22_RS03420 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DBK22_RS03425 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DBK22_RS03430 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DBK22_RS03435 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DBK22_RS03440 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DBK22_RS03455 ENOG4107RIQ Sulfate adenylate transferase DBK22_RS03465 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DBK22_RS03470 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DBK22_RS03475 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DBK22_RS03480 ENOG4105F23 Fibronectin-binding protein DBK22_RS03490 ENOG4105DSJ YicC domain protein DBK22_RS03495 ENOG4105KC4 UPF0296 protein DBK22_RS03500 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DBK22_RS03510 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DBK22_RS03515 ENOG4105C25 Primosomal protein n' DBK22_RS03520 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DBK22_RS03525 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DBK22_RS03530 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DBK22_RS03535 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DBK22_RS03540 ENOG4108ZF3 Phosphatase DBK22_RS03545 ENOG4105D9P serine threonine protein kinase DBK22_RS03550 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DBK22_RS03555 ENOG4105DJV ribulose-phosphate 3-epimerase DBK22_RS03560 ENOG4105FJ0 thiamine DBK22_RS03570 ENOG4105VB9 50S ribosomal protein l28 DBK22_RS03575 ENOG4108ZAA Alkaline-shock protein DBK22_RS03580 ENOG4105DP4 dak2 domain fusion protein ylov DBK22_RS03590 ENOG4105EJQ L-serine dehydratase DBK22_RS03595 ENOG4105CB5 ATP-dependent DNA helicase recG DBK22_RS03600 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DBK22_RS03605 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DBK22_RS03610 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DBK22_RS03615 ENOG4105CHR reductase DBK22_RS03620 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DBK22_RS03625 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DBK22_RS03630 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DBK22_RS03635 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DBK22_RS03645 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DBK22_RS03655 ENOG4105K5M 30s ribosomal protein S16 DBK22_RS03660 ENOG4108BW8 UPF0109 protein DBK22_RS03675 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DBK22_RS03680 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DBK22_RS03685 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DBK22_RS03690 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DBK22_RS03700 ENOG4105VM1 flagellar DBK22_RS03705 ENOG4105CMV Succinyl-CoA synthetase subunit beta DBK22_RS03710 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DBK22_RS03715 ENOG4105C79 DNA protecting protein DprA DBK22_RS03720 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DBK22_RS03725 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DBK22_RS03730 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DBK22_RS03735 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DBK22_RS03740 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DBK22_RS03750 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DBK22_RS03755 ENOG4108ZC9 flagellar basal-body rod protein flgc DBK22_RS03760 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DBK22_RS03765 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DBK22_RS03770 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DBK22_RS03785 ENOG4106YF4 Flagellar biosynthesis chaperone DBK22_RS03795 ENOG410696Y Flagellar hook-length control protein DBK22_RS03800 ENOG410822I Flagellar hook capping protein DBK22_RS03805 ENOG4108JQA flagellar DBK22_RS03810 ENOG41068WV flagellar FlbD family protein DBK22_RS03820 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DBK22_RS03825 ENOG4105DD5 Flagellar motor switch protein DBK22_RS03830 ENOG4107YTP response regulator receiver protein DBK22_RS03840 ENOG4105CN7 Flagellar biosynthetic protein FliP DBK22_RS03845 ENOG4105VS8 Flagellar biosynthetic protein fliq DBK22_RS03850 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DBK22_RS03855 ENOG4105D00 flagellar biosynthetic protein flhB DBK22_RS03860 ENOG4105D7B Flagellar biosynthesis protein flha DBK22_RS03865 ENOG4105FZW flagellar biosynthesis regulator FlhF DBK22_RS03875 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DBK22_RS03880 ENOG4105CBS Chea signal transduction histidine kinase DBK22_RS03885 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DBK22_RS03895 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DBK22_RS03900 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS03910 ENOG4105CE9 30S ribosomal protein S2 DBK22_RS03920 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DBK22_RS03925 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DBK22_RS03930 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DBK22_RS03935 ENOG4105KNE Phosphatidate cytidylyltransferase DBK22_RS03945 ENOG4105DZP Membrane-associated zinc metalloprotease DBK22_RS03950 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DBK22_RS03955 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DBK22_RS03960 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DBK22_RS03965 ENOG4105CHV Transcription elongation factor NusA DBK22_RS03970 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DBK22_RS03975 ENOG4105VHM ribosomal protein DBK22_RS03980 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DBK22_RS03985 ENOG4105W7A Protein of unknown function (DUF503) DBK22_RS03990 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DBK22_RS03995 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DBK22_RS04000 ENOG4105DTN riboflavin biosynthesis protein ribF DBK22_RS04005 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DBK22_RS04010 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DBK22_RS04020 ENOG4105C1V Peptidase, M16 DBK22_RS04030 ENOG4105E35 Dipicolinate synthase subunit A DBK22_RS04035 ENOG4108S0H Dipicolinic acid synthetase, b subunit DBK22_RS04040 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DBK22_RS04050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DBK22_RS04060 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DBK22_RS04070 ENOG4105CNU cell division protein FtsK DBK22_RS04075 ENOG4105FDP GntR family transcriptional regulator DBK22_RS04090 ENOG4105EYF MMPL domain protein DBK22_RS04105 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DBK22_RS04110 ENOG4105XZV Protein of unknown function (DUF3243) DBK22_RS04125 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DBK22_RS04130 ENOG4105CEV competence damage-inducible protein DBK22_RS04135 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DBK22_RS04140 ENOG4108A04 Beta-lactamase DBK22_RS04150 ENOG4105D48 metallophosphoesterase DBK22_RS04155 ENOG4105MCT stage V sporulation protein S DBK22_RS04160 ENOG4105CPQ Dehydrogenase DBK22_RS04165 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DBK22_RS04170 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DBK22_RS04190 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DBK22_RS04220 ENOG4108151 Beta-lactamase domain protein DBK22_RS04225 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DBK22_RS04230 ENOG4108JA1 polyketide synthase DBK22_RS04235 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DBK22_RS04240 ENOG41062T2 Acyl carrier protein DBK22_RS04245 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DBK22_RS04250 ENOG4108MGH Enoyl-CoA hydratase DBK22_RS04255 ENOG4108KQ6 Enoyl-CoA hydratase DBK22_RS04260 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS04265 ENOG4107SQU synthase DBK22_RS04275 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS04285 ENOG4106A3M Cytochrome p-450 DBK22_RS04290 ENOG4105WFK nuclease DBK22_RS04295 ENOG4105XPP Protein of unknown function (DUF1275) DBK22_RS04305 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DBK22_RS04315 ENOG4105K7W phage-related replication protein DBK22_RS04320 ENOG4108X3M OsmC Ohr family protein DBK22_RS04345 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DBK22_RS04370 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DBK22_RS04375 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DBK22_RS04380 ENOG4105U6W MutT NUDIX family protein DBK22_RS04385 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DBK22_RS04395 ENOG4106F1P AAA ATPase, central domain protein DBK22_RS04400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DBK22_RS04405 ENOG4105CXI aluminum resistance protein DBK22_RS04410 ENOG4105KV4 Transcriptional regulator DBK22_RS04415 ENOG4105C5F glutamine synthetase DBK22_RS04425 ENOG4105CT4 transporter DBK22_RS04430 ENOG4105DSG hydrolase family 43 DBK22_RS04440 ENOG4105C93 Xylose Isomerase DBK22_RS04445 ENOG4105CMG Carbohydrate kinase DBK22_RS04450 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DBK22_RS04480 ENOG4105DQ4 alcohol dehydrogenase DBK22_RS04505 ENOG4105EPI acetyltransferase, (GNAT) family DBK22_RS04540 ENOG4108M1A Chitin-binding protein DBK22_RS04565 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DBK22_RS04570 ENOG4105K7W phage-related replication protein DBK22_RS04590 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DBK22_RS04600 ENOG4108SVB resolvase DBK22_RS04605 ENOG4105VPS UPF0291 protein DBK22_RS04610 ENOG4105CV1 Transketolase (EC 2.2.1.1) DBK22_RS04620 ENOG4105VXM UPF0154 protein DBK22_RS04630 ENOG4107QIV Cytochrome c biogenesis protein DBK22_RS04665 ENOG4108I0Z Aconitate hydratase DBK22_RS04670 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DBK22_RS04685 ENOG41067CD Small, acid-soluble spore protein Tlp DBK22_RS04695 ENOG4105MI2 DBK22_RS04700 ENOG4105W8X HesB YadR YfhF-family protein DBK22_RS04705 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DBK22_RS04710 ENOG4105K4P CoA-binding domain protein DBK22_RS04715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DBK22_RS04740 ENOG4105CPQ Dehydrogenase DBK22_RS04745 ENOG4108UHU Aldolase DBK22_RS04750 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DBK22_RS04755 ENOG4105DMW Dehydrogenase reductase DBK22_RS04765 ENOG4108I5G Major Facilitator superfamily DBK22_RS04780 ENOG4105FVX DBK22_RS04790 ENOG4107R39 (ABC) transporter DBK22_RS04825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DBK22_RS04835 ENOG4107SYN Glycosyl hydrolases family 43 DBK22_RS04860 ENOG4105DTD Dehydrogenase DBK22_RS04865 ENOG4108IIH CoA-transferase subunit B DBK22_RS04870 ENOG4105D6N CoA-transferase, subunit a DBK22_RS04875 ENOG4105CY2 Citrate transporter DBK22_RS04880 ENOG4106A3M Cytochrome p-450 DBK22_RS04885 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DBK22_RS04890 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DBK22_RS04895 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DBK22_RS04900 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DBK22_RS04905 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) DBK22_RS04920 ENOG4107T5V SNARE associated Golgi DBK22_RS04925 ENOG4107QX3 carboxylase DBK22_RS04930 ENOG4105E39 Enoyl-CoA hydratase DBK22_RS04935 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DBK22_RS04940 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DBK22_RS04945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DBK22_RS04950 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS04955 ENOG4105C1G acyl-Coa dehydrogenase DBK22_RS04960 ENOG4105F32 YngK protein DBK22_RS04965 ENOG4106U2H Protein of unknown function (DUF1360) DBK22_RS04975 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS04980 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS04990 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS04995 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DBK22_RS05000 ENOG4108N2V aldose 1-epimerase DBK22_RS05005 ENOG4107QJQ Mate efflux family protein DBK22_RS05035 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DBK22_RS05055 ENOG41068G1 DBK22_RS05065 ENOG4107X35 defense response to bacterium DBK22_RS05135 ENOG4105CAR Terminase, large subunit DBK22_RS05175 ENOG410682Q Phage transcriptional regulator, ArpU DBK22_RS05285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DBK22_RS05290 ENOG4108RWP Major Facilitator Superfamily protein DBK22_RS05295 ENOG4105WAB arsR family transcriptional regulator DBK22_RS05300 ENOG4105C22 threonyL-tRNA synthetase DBK22_RS05305 ENOG4108KSA LysR family transcriptional regulator DBK22_RS05310 ENOG4105CB2 alcohol dehydrogenase DBK22_RS05320 ENOG4105BZ8 glutamate synthase DBK22_RS05325 ENOG4105CBC glutamate synthase DBK22_RS05330 ENOG4105C5Q Transcriptional regulator DBK22_RS05335 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DBK22_RS05375 ENOG4108UB7 DBK22_RS05380 ENOG4105IE8 Alpha-ketoglutarate permease DBK22_RS05385 ENOG4107U6E carbohydrate kinase FGGY DBK22_RS05390 ENOG4108M3J Dehydrogenase DBK22_RS05395 ENOG4108J2R molybdopterin oxidoreductase DBK22_RS05420 ENOG4106ANW SMI1_KNR4 DBK22_RS05430 ENOG4108Z7R Chaperone CsaA DBK22_RS05435 ENOG4105FTV AraC Family Transcriptional Regulator DBK22_RS05445 ENOG4108W8B Beta-lactamase domain protein DBK22_RS05455 ENOG4105KTU Transcriptional regulator, arsr family DBK22_RS05465 ENOG4108SJC Membrane DBK22_RS05490 ENOG41069ER domain protein DBK22_RS05495 ENOG4105C9U ATP-dependent DNA helicase RecQ DBK22_RS05505 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DBK22_RS05510 ENOG4105SCY DNAK suppressor DBK22_RS05555 ENOG4105C26 Dehydrogenase DBK22_RS05560 ENOG4105EWU Squalene--hopene cyclase DBK22_RS05565 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DBK22_RS05570 ENOG4105C8J )-transporter DBK22_RS05575 ENOG4105C09 Bile acid DBK22_RS05585 ENOG4105C7S Dehydrogenase DBK22_RS05590 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DBK22_RS05595 ENOG4107T89 von Willebrand factor, type A DBK22_RS05600 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DBK22_RS05610 ENOG4105K4H Nlp p60 protein DBK22_RS05615 ENOG41087PP glycosyltransferase MGT family DBK22_RS05625 ENOG4107QMU Mate efflux family protein DBK22_RS05630 ENOG4106SCS STAS domain DBK22_RS05650 ENOG4105FR1 rard protein DBK22_RS05665 ENOG41090U3 tautomerase DBK22_RS05685 ENOG4105FBA Phospholipase Carboxylesterase DBK22_RS05700 ENOG4105E1V na solute symporter DBK22_RS05710 ENOG4105CS2 ec 3.2.1.21 DBK22_RS05715 ENOG4108S3Y transcriptional regulator DBK22_RS05735 ENOG4108VXD carboxy-peptidase DBK22_RS05740 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DBK22_RS05750 ENOG4106Z5R DBK22_RS05755 ENOG410841Q phosphoesterase PA-phosphatase related protein DBK22_RS05785 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DBK22_RS05790 ENOG4108TSC N-acetyltransferase DBK22_RS05795 ENOG4107S4Y M20 DapE family protein YgeY DBK22_RS05810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DBK22_RS05815 ENOG4105FTQ Dna gyrase DBK22_RS05880 ENOG410780I phosphoprotein phosphatase activity DBK22_RS05890 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DBK22_RS05905 ENOG4106ANW SMI1_KNR4 DBK22_RS05910 ENOG4106BHF DBK22_RS05920 ENOG4107Y9E nuclease DBK22_RS05935 ENOG4105E0X reductase DBK22_RS05940 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DBK22_RS05950 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) DBK22_RS05955 ENOG41090WU lipolytic protein G-D-S-L family DBK22_RS05960 ENOG4108KF3 Electron transport protein SCO1 SenC DBK22_RS05970 ENOG4105C7B Threonine dehydratase DBK22_RS05980 ENOG4108UT2 hemolysin iii DBK22_RS05990 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DBK22_RS05995 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DBK22_RS06005 ENOG4107YX5 Pfam:DUF548 DBK22_RS06010 ENOG4108Y6J UPF0403 protein DBK22_RS06015 ENOG4105C01 Dihydroxy-acid dehydratase DBK22_RS06030 ENOG4108V06 Glutathione peroxidase DBK22_RS06035 ENOG4105CVG Homoserine O-transsuccinylase DBK22_RS06080 ENOG41081VK Ribonuclease DBK22_RS06105 ENOG410890F Dynamin family DBK22_RS06120 ENOG41065KQ synthase DBK22_RS06140 ENOG410900G Protein of unknown function (DUF421) DBK22_RS06155 ENOG4105C2W permease DBK22_RS06160 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DBK22_RS06165 ENOG4105CTD carboxy-peptidase DBK22_RS06170 ENOG4105DVT helicase DBK22_RS06185 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DBK22_RS06195 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DBK22_RS06200 ENOG4108UKS UPF0398 protein DBK22_RS06215 ENOG4107X2U Inherit from COG: Exonuclease-like protein DBK22_RS06220 ENOG4108I5C dEAD DEAH box helicase DBK22_RS06265 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DBK22_RS06270 ENOG4105BZ4 penicillin-binding protein DBK22_RS06280 ENOG4105CSM endonuclease III DBK22_RS06290 ENOG4105C5S asparaginyl-tRNA synthetase DBK22_RS06295 ENOG4105CHM Aminotransferase DBK22_RS06305 ENOG4105YAC DBK22_RS06310 ENOG4105DVT helicase DBK22_RS06315 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DBK22_RS06325 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DBK22_RS06335 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DBK22_RS06340 ENOG4105CPK Glycosyl transferase (Group 1 DBK22_RS06345 ENOG4105FJR Lmbe family DBK22_RS06350 ENOG4108Z5K methylglyoxal synthase DBK22_RS06355 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DBK22_RS06360 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DBK22_RS06365 ENOG4108JYZ YitT family DBK22_RS06370 ENOG4105F0F Oxalate decarboxylase DBK22_RS06390 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DBK22_RS06410 ENOG41068YB TPR repeat-containing protein DBK22_RS06415 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DBK22_RS06425 ENOG4105CIH Imidazole acetol-phosphate transaminase DBK22_RS06435 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DBK22_RS06440 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DBK22_RS06445 ENOG4105DK0 Indole-3-glycerol phosphate synthase DBK22_RS06455 ENOG4105CRQ synthase (Component I) DBK22_RS06460 ENOG4105KHN chorismate mutase DBK22_RS06470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DBK22_RS06475 ENOG4105BZU Histidine kinase DBK22_RS06480 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DBK22_RS06485 ENOG4105EAH synthase DBK22_RS06490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DBK22_RS06495 ENOG4105XXQ heptaprenyl diphosphate synthase component I DBK22_RS06500 ENOG4105WP2 Tryptophan RNA-binding attenuator protein DBK22_RS06505 ENOG4105EUJ GTP cyclohydrolase i DBK22_RS06510 ENOG4105K70 DNA-binding protein DBK22_RS06515 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DBK22_RS06530 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DBK22_RS06535 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DBK22_RS06555 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DBK22_RS06560 ENOG4105CAT Cytidine monophosphate kinase DBK22_RS06575 ENOG4105MSI germination protein ypeb DBK22_RS06585 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DBK22_RS06590 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DBK22_RS06605 ENOG4107RGJ metallophosphoesterase DBK22_RS06620 ENOG4105I7S Abortive infection protein DBK22_RS06625 ENOG4105C9U ATP-dependent DNA helicase RecQ DBK22_RS06630 ENOG4105T7X DBK22_RS06640 ENOG4108SAX Membrane DBK22_RS06645 ENOG4108JQ1 Dehydrogenase DBK22_RS06660 ENOG4105BZU Histidine kinase DBK22_RS06665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS06670 ENOG4105CRE cytochrome C DBK22_RS06675 ENOG4107TWT Cytochrome c biogenesis protein DBK22_RS06685 ENOG4105FE9 pseudouridine synthase DBK22_RS06695 ENOG4108JIC nucleoside recognition domain protein DBK22_RS06700 ENOG4105DZ1 carboxypeptidase DBK22_RS06710 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DBK22_RS06715 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DBK22_RS06735 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DBK22_RS06740 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DBK22_RS06745 ENOG4108R6K riboflavin synthase, subunit alpha DBK22_RS06770 ENOG4107ZE5 PPIases accelerate the folding of proteins DBK22_RS06775 ENOG4105PTM secreted protein DBK22_RS06780 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DBK22_RS06790 ENOG4105G6R Stage v sporulation protein ae DBK22_RS06800 ENOG4105CZ3 stage V sporulation protein ad DBK22_RS06805 ENOG41090VF Stage v sporulation protein ac DBK22_RS06820 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS06825 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DBK22_RS06830 ENOG41082AN stage II sporulation protein DBK22_RS06835 ENOG4105DZ1 carboxypeptidase DBK22_RS06840 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DBK22_RS06845 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DBK22_RS06850 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DBK22_RS06860 ENOG4105I3K Ferric uptake regulator, Fur family DBK22_RS06865 ENOG4105MZ9 stage II sporulation protein m DBK22_RS06885 ENOG4105DFD Na H antiporter DBK22_RS06890 ENOG4108IJ0 Aspartate ammonia-lyase DBK22_RS06895 ENOG4105HDK L-asparaginase DBK22_RS06900 ENOG4108IMY Transcriptional regulator DBK22_RS06910 ENOG4108YZ4 nudix hydrolase DBK22_RS06920 ENOG4105CPC Aldo Keto reductase DBK22_RS06940 ENOG4106HZJ DBK22_RS06945 ENOG4105RHY Pfam:UPF0157 DBK22_RS06950 ENOG4105KAC Antibiotic biosynthesis monooxygenase DBK22_RS06955 ENOG4108XET gCN5-related N-acetyltransferase DBK22_RS06960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DBK22_RS06975 ENOG4105C02 permease DBK22_RS06985 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase DBK22_RS06990 ENOG4105CS9 pantothenic acid kinase DBK22_RS07000 ENOG4108IXY short-chain dehydrogenase reductase DBK22_RS07005 ENOG41069FQ Metallo-beta-lactamase superfamily DBK22_RS07010 ENOG4105II7 pyrroline-5-carboxylate reductase DBK22_RS07015 ENOG4108KQ6 Enoyl-CoA hydratase DBK22_RS07020 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DBK22_RS07025 ENOG4106A3M Cytochrome p-450 DBK22_RS07040 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS07045 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS07055 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS07065 ENOG4105CHR reductase DBK22_RS07070 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS07085 ENOG4107QKG PfaD family DBK22_RS07095 ENOG4108K70 Transcriptional regulator DBK22_RS07105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DBK22_RS07115 ENOG410861F 50S ribosomal protein L33 DBK22_RS07120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DBK22_RS07125 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DBK22_RS07130 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DBK22_RS07135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DBK22_RS07145 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) DBK22_RS07150 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DBK22_RS07155 ENOG4108HNZ carboxyl transferase DBK22_RS07160 ENOG4108ZVT methylmalonyl-coA epimerase DBK22_RS07170 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DBK22_RS07175 ENOG4108QEG Membrane DBK22_RS07180 ENOG4105CDA abc transporter atp-binding protein DBK22_RS07185 ENOG4105E5Q amino acid AbC transporter DBK22_RS07190 ENOG4108HW3 (ABC) transporter DBK22_RS07195 ENOG4108Y6J UPF0403 protein DBK22_RS07200 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DBK22_RS07205 ENOG4105C7S Dehydrogenase DBK22_RS07210 ENOG4105CPP Dehydrogenase, E1 component DBK22_RS07225 ENOG4105CKM Branched-chain carboxylic acid kinase DBK22_RS07230 ENOG4107RDP Dehydrogenase DBK22_RS07240 ENOG4108JUB Transcriptional regulator DBK22_RS07245 ENOG4106CCJ Protein of unknown function (DUF2627) DBK22_RS07250 ENOG4105CR4 methylisocitrate lyase DBK22_RS07255 ENOG4105DXD 2-methylcitrate dehydratase DBK22_RS07265 ENOG4105C1G acyl-Coa dehydrogenase DBK22_RS07270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DBK22_RS07280 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DBK22_RS07285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DBK22_RS07305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DBK22_RS07320 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DBK22_RS07325 ENOG4107QQR Sporulation DBK22_RS07330 ENOG4105S1Z Stage IV sporulation protein B DBK22_RS07335 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DBK22_RS07340 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DBK22_RS07345 ENOG4105DX0 Hemolysin A DBK22_RS07350 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DBK22_RS07355 ENOG4105CTB Polyprenyl synthetase DBK22_RS07360 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DBK22_RS07365 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DBK22_RS07370 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DBK22_RS07375 ENOG4105M7K Involved in the transcription termination process (By similarity) DBK22_RS07380 ENOG4108ZSR alkaline shock protein DBK22_RS07385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DBK22_RS07405 ENOG410644B Stage III sporulation protein af DBK22_RS07415 ENOG4105KQ4 Stage iii sporulation protein ad DBK22_RS07420 ENOG4108CQH stage III sporulation protein AC DBK22_RS07425 ENOG4105KR5 Stage iii sporulation protein DBK22_RS07430 ENOG4105CD2 stage iii sporulation protein aa DBK22_RS07440 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DBK22_RS07445 ENOG4105DC7 peptidase M24 DBK22_RS07455 ENOG4105CBJ Metal-dependent enzyme DBK22_RS07475 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DBK22_RS07480 ENOG4105WZW rhodanese family DBK22_RS07485 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DBK22_RS07495 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DBK22_RS07500 ENOG4105C0D helicase DBK22_RS07515 ENOG4108IMY Transcriptional regulator DBK22_RS07525 ENOG4105VFR signal peptidase DBK22_RS07585 ENOG4105C37 (CBS) domain DBK22_RS07610 ENOG4105C5X domain protein DBK22_RS07655 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DBK22_RS07660 ENOG4105WDJ 50S ribosomal protein L33 DBK22_RS07670 ENOG41068DG YceG-like family DBK22_RS07675 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DBK22_RS07680 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DBK22_RS07685 ENOG4105E2Z phosphate ABC transporter (Permease DBK22_RS07690 ENOG4105C8U phosphate abc transporter DBK22_RS07695 ENOG4105CVA phosphate DBK22_RS07700 ENOG4107RF6 penicillin-binding protein DBK22_RS07710 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DBK22_RS07715 ENOG4105SXS Protein of unknown function (DUF456) DBK22_RS07730 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DBK22_RS07735 ENOG41063Y9 DBK22_RS07740 ENOG4108U5J '-nucleotidase DBK22_RS07745 ENOG4105N80 Ferric uptake regulator, Fur family DBK22_RS07750 ENOG4108JYZ YitT family DBK22_RS07755 ENOG41069ZM Protein of unknown function (DUF2624) DBK22_RS07760 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DBK22_RS07775 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DBK22_RS07780 ENOG4105EGD dinuclear metal center protein, YbgI family DBK22_RS07795 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS07800 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DBK22_RS07805 ENOG4108UPT UPF0178 protein DBK22_RS07810 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DBK22_RS07820 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DBK22_RS07825 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DBK22_RS07830 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DBK22_RS07840 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DBK22_RS07845 ENOG4105KG3 cytidine deaminase DBK22_RS07850 ENOG4107YR5 Diacylglycerol kinase DBK22_RS07855 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DBK22_RS07860 ENOG4105CTJ Metal Dependent Phosphohydrolase DBK22_RS07865 ENOG4105C9A Phoh family DBK22_RS07870 ENOG4105EI1 sporulation protein yqfd DBK22_RS07875 ENOG41068P3 sporulation protein YqfC DBK22_RS07885 ENOG4105DI5 UPF0365 protein DBK22_RS07890 ENOG4105F7J membrane-bound serine protease DBK22_RS07895 ENOG4105KTH gatB Yqey DBK22_RS07910 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DBK22_RS07915 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DBK22_RS07920 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DBK22_RS07925 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DBK22_RS07930 ENOG4105CFG Acts as a chaperone (By similarity) DBK22_RS07935 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DBK22_RS07940 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DBK22_RS07945 ENOG4105CSA Coproporphyrinogen iii oxidase DBK22_RS07950 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DBK22_RS07960 ENOG4108ZRV stage ii sporulation protein p DBK22_RS07965 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DBK22_RS07970 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DBK22_RS07975 ENOG4105TQK DNA polymerase iii, delta' subunit DBK22_RS07990 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DBK22_RS07995 ENOG4108UK2 deaminase DBK22_RS08000 ENOG4105KQC Competence protein DBK22_RS08010 ENOG4108D32 Methyltransferase DBK22_RS08020 ENOG4108WF2 Metal Dependent Phosphohydrolase DBK22_RS08025 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DBK22_RS08030 ENOG410812S Rna-binding protein DBK22_RS08035 ENOG4105E2X shikimate dehydrogenase DBK22_RS08040 ENOG4105CQW ribosome biogenesis GTPase YqeH DBK22_RS08045 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DBK22_RS08065 ENOG41080BT SNARE associated Golgi DBK22_RS08080 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS08095 ENOG41086D8 Transcriptional regulator DBK22_RS08105 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DBK22_RS08120 ENOG4108U7W acetyltransferase DBK22_RS08135 ENOG4108HCJ Hydrolase DBK22_RS08140 ENOG4108HCJ Hydrolase DBK22_RS08150 ENOG4105DG6 mannose-6-phosphate isomerase DBK22_RS08155 ENOG4105DM4 PTS System DBK22_RS08170 ENOG4108Z66 YbaK ebsC protein DBK22_RS08175 ENOG4107RSM transcriptional regulator DBK22_RS08180 ENOG4105D94 Major Facilitator Superfamily DBK22_RS08185 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DBK22_RS08190 ENOG41082JN Transcriptional regulator DBK22_RS08205 ENOG4105TMB Formate nitrite transporter DBK22_RS08210 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DBK22_RS08215 ENOG4108JB9 formate dehydrogenase DBK22_RS08230 ENOG4105C28 cystathionine DBK22_RS08260 ENOG4107XRG penicillin-binding protein DBK22_RS08265 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DBK22_RS08275 ENOG4105CFP Peptidase U32 DBK22_RS08280 ENOG4105XYU peptidase (U32 family) DBK22_RS08285 ENOG4108VQJ O-methyltransferase DBK22_RS08290 ENOG4105HHA aminodeoxychorismate lyase DBK22_RS08300 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DBK22_RS08305 ENOG4105VBH UPF0297 protein DBK22_RS08310 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DBK22_RS08315 ENOG4105C02 permease DBK22_RS08320 ENOG4105CDA abc transporter atp-binding protein DBK22_RS08325 ENOG4105CT1 (ABC) transporter DBK22_RS08330 ENOG4105EAD ABC transporter DBK22_RS08335 ENOG4105DRP amino acid AbC transporter DBK22_RS08345 ENOG41060CR DBK22_RS08355 ENOG4105C7H Helicase, RecD TraA family DBK22_RS08365 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DBK22_RS08370 ENOG4105C3J Cysteine desulfurase DBK22_RS08380 ENOG4105D1H recombination factor protein RarA DBK22_RS08385 ENOG4105CUZ uba thif-type nad fad binding protein DBK22_RS08395 ENOG4105C9M aspartyl-trna synthetase DBK22_RS08400 ENOG4105CUT histidyl-tRNA synthetase DBK22_RS08410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DBK22_RS08415 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DBK22_RS08420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DBK22_RS08430 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DBK22_RS08435 ENOG41067VP Protein of unknown function (DUF1049) DBK22_RS08440 ENOG4105NCW Trka-c domain protein DBK22_RS08445 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DBK22_RS08455 ENOG4105CKP Polysaccharide Biosynthesis Protein DBK22_RS08460 ENOG4108QG2 Membrane DBK22_RS08465 ENOG4105NAP DBK22_RS08470 ENOG4105VIE preprotein translocase, subunit YajC DBK22_RS08475 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DBK22_RS08480 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DBK22_RS08485 ENOG41061AI Protein of unknown function (DUF2905) DBK22_RS08490 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DBK22_RS08495 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DBK22_RS08515 ENOG4106678 morphogenetic protein associated with SpoVID DBK22_RS08520 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DBK22_RS08525 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DBK22_RS08530 ENOG4108IYU L-aspartate oxidase DBK22_RS08545 ENOG4105CQC Prephenate dehydratase DBK22_RS08555 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DBK22_RS08565 ENOG4105K46 50S ribosomal protein l27 DBK22_RS08570 ENOG4105X36 (ribosomal) protein DBK22_RS08575 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DBK22_RS08590 ENOG4107QMS site-determining protein DBK22_RS08595 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DBK22_RS08600 ENOG4105YHC Rod shape-determining protein MreD DBK22_RS08605 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DBK22_RS08610 ENOG4105DFF Rod shape-determining protein mreb DBK22_RS08615 ENOG4105W5Q DNA repair protein (RadC DBK22_RS08620 ENOG4108Z03 MAF-like protein DBK22_RS08630 ENOG4106A3R peptidase DBK22_RS08635 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DBK22_RS08640 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DBK22_RS08650 ENOG4106AR7 Spore coat protein DBK22_RS08655 ENOG41068KH stage VI sporulation protein D DBK22_RS08660 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DBK22_RS08665 ENOG4105D52 delta-aminolevulinic acid dehydratase DBK22_RS08675 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DBK22_RS08685 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DBK22_RS08695 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DBK22_RS08700 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DBK22_RS08705 ENOG4108IUQ atp-dependent protease DBK22_RS08710 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DBK22_RS08715 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DBK22_RS08725 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DBK22_RS08730 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DBK22_RS08735 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DBK22_RS08745 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DBK22_RS08750 ENOG4108ZP8 Acetolactate synthase small subunit DBK22_RS08755 ENOG4105C7K acetolactate synthase DBK22_RS08780 ENOG4105M59 Phosphodiesterase, mj0936 family DBK22_RS08785 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DBK22_RS08790 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DBK22_RS08795 ENOG4108XJQ germination protein DBK22_RS08800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DBK22_RS08805 ENOG41067TZ transcriptional regulator, MarR family DBK22_RS08810 ENOG4105PFC Transcriptional regulator DBK22_RS08820 ENOG4105E33 succinate dehydrogenase DBK22_RS08830 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DBK22_RS08840 ENOG4105CFH Aspartokinase DBK22_RS08845 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DBK22_RS08850 ENOG4105K63 Thioredoxin DBK22_RS08855 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DBK22_RS08860 ENOG4105C10 Electron transfer flavoprotein DBK22_RS08865 ENOG4105BZJ Electron transfer flavoprotein DBK22_RS08870 ENOG41060WC Enoyl-CoA hydratase DBK22_RS08875 ENOG4107Z3H Transcriptional regulator, TetR family DBK22_RS08880 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS08885 ENOG4108YV3 Protein of unknown function (DUF2711) DBK22_RS08895 ENOG4105C98 muts2 protein DBK22_RS08900 ENOG4105DCG PHP domain protein DBK22_RS08915 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DBK22_RS08920 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DBK22_RS08925 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DBK22_RS08930 ENOG4108RWN rrna methyltransferase DBK22_RS08935 ENOG41067MF small acid-soluble spore protein DBK22_RS08945 ENOG4105CQB FAD linked oxidase domain protein DBK22_RS08950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DBK22_RS08960 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DBK22_RS08965 ENOG4105DRS transport system, permease DBK22_RS08980 ENOG4108MDK Dehydrogenase DBK22_RS08990 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase DBK22_RS08995 ENOG4105EF1 ribulokinase DBK22_RS09005 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DBK22_RS09010 ENOG4105CN9 Peptidase m42 family protein DBK22_RS09020 ENOG410696E Membrane DBK22_RS09025 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DBK22_RS09030 ENOG4105VJV 50s ribosomal protein L35 DBK22_RS09035 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DBK22_RS09040 ENOG41067MG lrgb family DBK22_RS09050 ENOG4105DY9 regulatoR DBK22_RS09055 ENOG4108HRK Histidine kinase DBK22_RS09060 ENOG4105U0R haloacid dehalogenase-like hydrolase DBK22_RS09065 ENOG4105C22 threonyL-tRNA synthetase DBK22_RS09070 ENOG4108TDW sporulation protein YtxC DBK22_RS09095 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DBK22_RS09100 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DBK22_RS09105 ENOG4105KVH Transcriptional regulator DBK22_RS09110 ENOG4105F27 Major Facilitator DBK22_RS09115 ENOG4105CV8 reductase DBK22_RS09120 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DBK22_RS09130 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DBK22_RS09135 ENOG4105C2M dna polymerase I DBK22_RS09140 ENOG4105BZU Histidine kinase DBK22_RS09145 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DBK22_RS09155 ENOG4108HMX isocitrate dehydrogenase (NADP) DBK22_RS09160 ENOG4105BZN citrate synthase DBK22_RS09170 ENOG4105G7B Protein of unknown function (DUF2992) DBK22_RS09180 ENOG4108REF Sporulation integral membrane protein ytvi DBK22_RS09185 ENOG4105FS0 cytoplasmic membrane protein DBK22_RS09190 ENOG4105CA9 Pyruvate kinase DBK22_RS09195 ENOG4105CTQ phosphohexokinase DBK22_RS09200 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DBK22_RS09205 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DBK22_RS09210 ENOG4105C6K Malic enzyme DBK22_RS09215 ENOG4105C0B DNA polymerase III (alpha subunit) DBK22_RS09220 ENOG4105VV2 DBK22_RS09230 ENOG4106EVM DBK22_RS09235 ENOG4105SFS phosphoesterase RecJ domain protein DBK22_RS09250 ENOG4105E8R UPF0173 metal-dependent hydrolase DBK22_RS09260 ENOG4105CH7 arginosuccinase DBK22_RS09265 ENOG4105CDH Citrulline--aspartate ligase DBK22_RS09270 ENOG4105EPU Molybdenum cofactor synthesis domain protein DBK22_RS09275 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DBK22_RS09285 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DBK22_RS09290 ENOG4105KBJ sporulation protein ytfj DBK22_RS09300 ENOG4105VK3 rdd domain containing protein DBK22_RS09305 ENOG4105D07 Signal peptide peptidase, SppA DBK22_RS09310 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DBK22_RS09315 ENOG4105EFZ amidohydrolase DBK22_RS09320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DBK22_RS09330 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DBK22_RS09355 ENOG4105U5Y Transcriptional regulator DBK22_RS09365 ENOG4105BZU Histidine kinase DBK22_RS09375 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DBK22_RS09380 ENOG410780I phosphoprotein phosphatase activity DBK22_RS09400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DBK22_RS09415 ENOG4108Z0Z intracellular protease Pfpi family DBK22_RS09435 ENOG4108NGU Transcriptional regulator DBK22_RS09450 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DBK22_RS09460 ENOG4105F1V Acetoin utilization protein DBK22_RS09465 ENOG4105W87 Cbs domain DBK22_RS09470 ENOG4105DGU Histone deacetylase DBK22_RS09475 ENOG4105ER2 Ompa motb domain protein DBK22_RS09480 ENOG4107R0U MotA TolQ exbB proton channel DBK22_RS09485 ENOG4105ETE Transcriptional regulator (LacI family DBK22_RS09490 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DBK22_RS09510 ENOG4105DFU Cell wall formation (By similarity) DBK22_RS09520 ENOG4108VDD TRNA binding domain protein DBK22_RS09535 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DBK22_RS09550 ENOG4105C6K Malic enzyme DBK22_RS09555 ENOG4105C8F Beta-lactamase domain protein DBK22_RS09560 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DBK22_RS09570 ENOG4108V15 phosphotransferase enzyme family DBK22_RS09585 ENOG4107F58 2'-5' rna ligase DBK22_RS09590 ENOG4105C6T cysteine synthase DBK22_RS09595 ENOG4107QSE Dipeptidase DBK22_RS09600 ENOG4105C7N Xanthine uracil vitamin C permease DBK22_RS09615 ENOG4105YW5 deoR family transcriptional regulator DBK22_RS09630 ENOG4105CBX hi0933 family DBK22_RS09635 ENOG4105C94 Transporter DBK22_RS09655 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DBK22_RS09660 ENOG4105I1K ABC transporter DBK22_RS09675 ENOG41085GJ domain protein DBK22_RS09680 ENOG4105C8T Leucyl-tRNA synthetase DBK22_RS09690 ENOG4105BZU Histidine kinase DBK22_RS09695 ENOG410605W Major Facilitator DBK22_RS09710 ENOG4105C19 ABC transporter DBK22_RS09715 ENOG4105EWM Histidine kinase DBK22_RS09725 ENOG4107R34 abc transporter permease protein DBK22_RS09730 ENOG4105C19 ABC transporter DBK22_RS09750 ENOG4105DVE abc transporter atp-binding protein DBK22_RS09755 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS09765 ENOG4105N5T Radical SAM Protein DBK22_RS09780 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DBK22_RS09790 ENOG4105E8V Alpha Beta Hydrolase Fold protein DBK22_RS09795 ENOG4108Z0R Transferase DBK22_RS09800 ENOG4105C85 amino acid DBK22_RS09805 ENOG4105CAQ asparagine synthetase DBK22_RS09810 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DBK22_RS09815 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DBK22_RS09830 ENOG4105D2X ABC transporter substrate-binding protein DBK22_RS09840 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DBK22_RS09855 ENOG4108RMU ferritin dps family protein DBK22_RS09870 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DBK22_RS09875 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DBK22_RS09880 ENOG4108V2W Carbonate dehydratase DBK22_RS09885 ENOG4105NRA 50s ribosomal protein l31 type b DBK22_RS09905 ENOG4105DTQ mandelate racemase muconate lactonizing DBK22_RS09910 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS09915 ENOG4108IPT Naphthoate synthase DBK22_RS09920 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DBK22_RS09925 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DBK22_RS09930 ENOG4105E4F Isochorismate synthase DBK22_RS10065 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DBK22_RS10070 ENOG4105DZ6 Band 7 protein DBK22_RS10080 ENOG4106DF1 DBK22_RS10085 ENOG4108VNY MOSC domain protein DBK22_RS10090 ENOG4108JB8 alcohol dehydrogenase DBK22_RS10095 ENOG4105C26 Dehydrogenase DBK22_RS10100 ENOG4105TRT Transcriptional regulator DBK22_RS10120 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DBK22_RS10125 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DBK22_RS10145 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DBK22_RS10155 ENOG4105EE0 oxidoreductase DBK22_RS10160 ENOG4108Z0Z intracellular protease Pfpi family DBK22_RS10165 ENOG4105C8Q Methyl-accepting chemotaxis DBK22_RS10170 ENOG4105C8Q Methyl-accepting chemotaxis DBK22_RS10175 ENOG4105C8Q Methyl-accepting chemotaxis DBK22_RS10180 ENOG4105C8Q Methyl-accepting chemotaxis DBK22_RS10195 ENOG4105EA8 2-Nitropropane dioxygenase DBK22_RS10200 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DBK22_RS10210 ENOG4105C37 (CBS) domain DBK22_RS10225 ENOG4107PBV potassium channel DBK22_RS10230 ENOG4107PBV potassium channel DBK22_RS10245 ENOG4107QYV phosphohexose isomerase DBK22_RS10255 ENOG4105CHJ isochorismatase hydrolase DBK22_RS10265 ENOG4107QW4 alcohol dehydrogenase DBK22_RS10270 ENOG4105WG9 Conserved Protein DBK22_RS10280 ENOG4105CHM Aminotransferase DBK22_RS10285 ENOG4108ZB6 transcriptional regulator AsnC family DBK22_RS10290 ENOG4108MUZ hydrolase DBK22_RS10300 ENOG4105C87 Aminotransferase class I and II DBK22_RS10305 ENOG4108HGU Histidine kinase DBK22_RS10310 ENOG4105Y38 Kinase-associated protein B DBK22_RS10325 ENOG4105BZ4 penicillin-binding protein DBK22_RS10330 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DBK22_RS10345 ENOG4108MRH transcriptional regulatory protein DBK22_RS10350 ENOG4105DIH basic membrane DBK22_RS10355 ENOG4108JQ9 ABC transporter DBK22_RS10360 ENOG4105UIB (ABC) transporter DBK22_RS10375 ENOG4105D65 subunit l DBK22_RS10380 ENOG4105HC0 Na H antiporter DBK22_RS10385 ENOG4108ZE9 Monovalent cation H antiporter subunit C DBK22_RS10390 ENOG4108JPZ Monovalent cation H antiporter subunit D DBK22_RS10395 ENOG4105SC1 monovalent cation H antiporter subunit E DBK22_RS10405 ENOG4105KJM monovalent cation h antiporter subunit g DBK22_RS10410 ENOG4105KA0 thioesterase Superfamily protein DBK22_RS10420 ENOG4105BZU Histidine kinase DBK22_RS10445 ENOG4105D58 Diguanylate phosphodiesterase DBK22_RS10450 ENOG4105DAP Nicotinate phosphoribosyltransferase DBK22_RS10475 ENOG4105C02 permease DBK22_RS10490 ENOG410904N short-chain dehydrogenase reductase DBK22_RS10525 ENOG4108K8K Transcriptional regulator DBK22_RS10530 ENOG4105DCF alanine dehydrogenase DBK22_RS10540 ENOG4105WQT MbtH domain protein DBK22_RS10545 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS10550 ENOG4105WQI isochorismatase DBK22_RS10555 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DBK22_RS10560 ENOG4105E4F Isochorismate synthase DBK22_RS10565 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DBK22_RS10570 ENOG4105NIV Esterase DBK22_RS10590 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DBK22_RS10605 ENOG41069ER domain protein DBK22_RS10620 ENOG4105CEP NADH dehydrogenase DBK22_RS10630 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DBK22_RS10645 ENOG4105CJ1 ABC, transporter DBK22_RS10670 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DBK22_RS10675 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DBK22_RS10680 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DBK22_RS10690 ENOG4105ZKE UPF0349 protein DBK22_RS10705 ENOG41083MR nifu domain-containing protein DBK22_RS10710 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DBK22_RS10715 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DBK22_RS10720 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DBK22_RS10725 ENOG4105D6E homoserine dehydrogenase DBK22_RS10735 ENOG4108W5N phosphatidylglycerophosphatase a DBK22_RS10740 ENOG4105D4U had-superfamily hydrolase, subfamily iia DBK22_RS10750 ENOG4105MMD transcriptional regulator DBK22_RS10755 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DBK22_RS10760 ENOG4105FAA peptidase M23 DBK22_RS10765 ENOG4108YTE sporulation protein YunB DBK22_RS10770 ENOG4107R8B 5'-nucleotidase DBK22_RS10780 ENOG4105I3N Conserved Protein DBK22_RS10790 ENOG4105CD3 dihydroorotase DBK22_RS10795 ENOG4105G9B Transcriptional regulator DBK22_RS10815 ENOG4105C5R Aminotransferase DBK22_RS10825 ENOG4108K8S endonuclease I DBK22_RS10830 ENOG4108IJ9 (ABC) transporter DBK22_RS10835 ENOG4105FDP GntR family transcriptional regulator DBK22_RS10840 ENOG4108KPW sugar kinase DBK22_RS10845 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DBK22_RS10850 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DBK22_RS10855 ENOG4105XN3 extracellular solute-binding protein family 1 DBK22_RS10860 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine DBK22_RS10880 ENOG4105PKS Excinuclease abc c subunit domain protein DBK22_RS10885 ENOG4107VFR oxidoreductase DBK22_RS10890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DBK22_RS10900 ENOG41083Q9 chitosanase DBK22_RS10905 ENOG4105DIW FeS assembly protein SUFB DBK22_RS10910 ENOG4108UNV SUF system FeS assembly protein, NifU family DBK22_RS10915 ENOG4105C9B Cysteine desulfurase DBK22_RS10920 ENOG4105JRK feS assembly protein SufD DBK22_RS10925 ENOG4105C3K feS assembly ATPase SufC DBK22_RS10940 ENOG4105D01 (LipO)protein DBK22_RS10945 ENOG4108UMI ABC transporter, permease DBK22_RS10950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DBK22_RS10975 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DBK22_RS10980 ENOG41080E8 Transcriptional regulator, Spx MgsR family DBK22_RS10985 ENOG4105C1G acyl-Coa dehydrogenase DBK22_RS10990 ENOG4105CHU acetyl-coa acetyltransferase DBK22_RS11010 ENOG4105C0R drug resistance transporter emrb qaca subfamily DBK22_RS11025 ENOG41067TZ transcriptional regulator, MarR family DBK22_RS11030 ENOG4105C0R drug resistance transporter emrb qaca subfamily DBK22_RS11035 ENOG4105MDS 4-oxalocrotonate tautomerase DBK22_RS11045 ENOG4105EGI Transcriptional regulator DBK22_RS11055 ENOG4105C5Q Transcriptional regulator DBK22_RS11075 ENOG4105E0A ABC, transporter DBK22_RS11090 ENOG4105E1F short-chain dehydrogenase reductase DBK22_RS11095 ENOG4105HUF DNA protection during starvation protein DBK22_RS11100 ENOG4105C0H protease DBK22_RS11110 ENOG4105F3H Histidine kinase DBK22_RS11120 ENOG41067SE Tetr family transcriptional regulator DBK22_RS11125 ENOG4105C9Q fumarate hydratase class II DBK22_RS11150 ENOG4105WH1 Two component transcriptional regulator luxr family DBK22_RS11155 ENOG4105ENE Histidine kinase DBK22_RS11170 ENOG41087YS Phage shock protein A DBK22_RS11185 ENOG4108WBT adenosyltransferase DBK22_RS11190 ENOG4105E0A ABC, transporter DBK22_RS11195 ENOG4105EHG Permease protein DBK22_RS11200 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DBK22_RS11205 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DBK22_RS11210 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DBK22_RS11220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DBK22_RS11230 ENOG4106DF4 Sigma-70, region 4 DBK22_RS11240 ENOG4105F0F Oxalate decarboxylase DBK22_RS11250 ENOG4105E0A ABC, transporter DBK22_RS11255 ENOG4105EHG Permease protein DBK22_RS11260 ENOG4105DQ5 transport system permease protein DBK22_RS11270 ENOG4105D5Q Arginine ornithine antiporter DBK22_RS11280 ENOG4107K5X Membrane-bound metal-dependent hydrolase DBK22_RS11285 ENOG4107QZ2 Sulfatase DBK22_RS11290 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DBK22_RS11295 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DBK22_RS11300 ENOG4105E0C molybdate abc transporter DBK22_RS11305 ENOG4105WH1 Two component transcriptional regulator luxr family DBK22_RS11310 ENOG4105BZU Histidine kinase DBK22_RS11315 ENOG4105CJ1 ABC, transporter DBK22_RS11325 ENOG4108KYE ABC-2 type transporter DBK22_RS11340 ENOG4105EEQ Na H antiporter DBK22_RS11345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DBK22_RS11350 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DBK22_RS11355 ENOG4105EEM helicase DBK22_RS11360 ENOG4105EN6 Membrane DBK22_RS11375 ENOG4107ZQN disulfide bond DBK22_RS11380 ENOG4105C59 p-type ATPase DBK22_RS11385 ENOG4105C59 p-type ATPase DBK22_RS11390 ENOG410681U heavy metal transport detoxification protein DBK22_RS11395 ENOG4105VPX protein, conserved in bacteria DBK22_RS11400 ENOG4105D9R oxidoreductase DBK22_RS11405 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DBK22_RS11445 ENOG4105DEN Luciferase family DBK22_RS11450 ENOG4105CDA abc transporter atp-binding protein DBK22_RS11475 ENOG4108XSB acetyltransferase, (GNAT) family DBK22_RS11480 ENOG4108KSA LysR family transcriptional regulator DBK22_RS11485 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DBK22_RS11490 ENOG41067XF inhibitor DBK22_RS11500 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DBK22_RS11505 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DBK22_RS11515 ENOG4105XZU Preprotein translocase, subunit SecG DBK22_RS11535 ENOG4105KVH Transcriptional regulator DBK22_RS11560 ENOG4105DA5 (ABC) transporter DBK22_RS11565 ENOG4105R40 Glycine betaine carnitine choline DBK22_RS11570 ENOG4108HQR Glycine betaine DBK22_RS11575 ENOG4105E90 ABC transporter DBK22_RS11580 ENOG4108IJ8 ABC transporter DBK22_RS11585 ENOG4107HG4 Transcriptional regulator DBK22_RS11590 ENOG4105R40 Glycine betaine carnitine choline DBK22_RS11595 ENOG4108HQR Glycine betaine DBK22_RS11600 ENOG4105E90 ABC transporter DBK22_RS11605 ENOG4108IJ8 ABC transporter DBK22_RS11610 ENOG4107HG4 Transcriptional regulator DBK22_RS11615 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DBK22_RS11625 ENOG4105T65 Membrane-associated protein DBK22_RS11630 ENOG4108W0I acetyltransferase DBK22_RS11645 ENOG4105FJR Lmbe family DBK22_RS11660 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DBK22_RS11665 ENOG4108IAJ Nad-dependent epimerase dehydratase DBK22_RS11670 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DBK22_RS11675 ENOG4107QQG Dehydrogenase DBK22_RS11680 ENOG4105IIU Aminopeptidase DBK22_RS11685 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DBK22_RS11690 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DBK22_RS11695 ENOG4105CP7 Triose-phosphate isomerase DBK22_RS11700 ENOG4105BZA Phosphoglycerate kinase DBK22_RS11705 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DBK22_RS11720 ENOG4105CMD Transcriptional regulator, GntR family DBK22_RS11725 ENOG4105DEN Luciferase family DBK22_RS11735 ENOG4105GZI Transcriptional regulator DBK22_RS11740 ENOG4107RT3 EamA-like transporter family DBK22_RS11765 ENOG410667J hydrolase DBK22_RS11775 ENOG4106KNT transcriptional regulator DBK22_RS11780 ENOG4105CMG Carbohydrate kinase DBK22_RS11785 ENOG4105C6Z Gluconate DBK22_RS11795 ENOG4107QR9 Iron-sulfur cluster binding protein DBK22_RS11800 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DBK22_RS11805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS11810 ENOG4105JXH GntR family transcriptional regulator DBK22_RS11815 ENOG4105DAA L-lactate DBK22_RS11820 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DBK22_RS11830 ENOG4108ZPC Polysaccharide pyruvyl transferase DBK22_RS11835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DBK22_RS11840 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family DBK22_RS11845 ENOG4105D3Q Sugar transferase DBK22_RS11855 ENOG4105K64 Glycosyl transferase, family 2 DBK22_RS11865 ENOG4107QRS glycosyltransferase group 2 family protein DBK22_RS11870 ENOG41068W6 Capsular polysaccharide biosynthesis protein DBK22_RS11875 ENOG4108KMV Glycosyl transferase (Group 1 DBK22_RS11880 ENOG4105K64 Glycosyl transferase, family 2 DBK22_RS11885 ENOG4108PQP glycosyl transferase group 1 DBK22_RS11895 ENOG4108QV3 biosynthesis protein DBK22_RS11900 ENOG4105HTX biosynthesis protein DBK22_RS11910 ENOG4105EBR Carboxylesterase DBK22_RS11930 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DBK22_RS11935 ENOG4105PY6 Phenolic acid decarboxylase DBK22_RS11940 ENOG4105NI3 Protein of unknown function (DUF3237) DBK22_RS11975 ENOG4105DDN Pentapeptide repeat-containing protein DBK22_RS11990 ENOG4108HKT sucrose-6-phosphate hydrolase DBK22_RS11995 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) DBK22_RS12000 ENOG4105ETE Transcriptional regulator (LacI family DBK22_RS12005 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DBK22_RS12010 ENOG4108KAM Transcriptional regulator DBK22_RS12015 ENOG4105C7F AcnD-accessory protein PrpF DBK22_RS12025 ENOG4108URH decarboxylase DBK22_RS12030 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DBK22_RS12035 ENOG4105CHH sulfate transporter DBK22_RS12040 ENOG4108V2W Carbonate dehydratase DBK22_RS12045 ENOG4105C5I Dehydrogenase DBK22_RS12050 ENOG4105GGE ribonuclease DBK22_RS12055 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DBK22_RS12060 ENOG4105KRI phosphocarrier protein (HPr DBK22_RS12065 ENOG4105CIE May be required for sporulation (By similarity) DBK22_RS12070 ENOG4105CHW UPF0052 protein DBK22_RS12075 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DBK22_RS12080 ENOG4108Z4K mutator MutT protein DBK22_RS12085 ENOG4105C3M thioredoxin reductase DBK22_RS12100 ENOG4105BZU Histidine kinase DBK22_RS12105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS12110 ENOG4105BZ1 (ABC) transporter DBK22_RS12115 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DBK22_RS12120 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DBK22_RS12125 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DBK22_RS12130 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DBK22_RS12135 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DBK22_RS12140 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DBK22_RS12145 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DBK22_RS12150 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DBK22_RS12160 ENOG4108S4C acetyltransferase DBK22_RS12165 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DBK22_RS12175 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DBK22_RS12180 ENOG4105CE4 GlcNAc 6-P deacetylase DBK22_RS12185 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DBK22_RS12190 ENOG4105FDP GntR family transcriptional regulator DBK22_RS12195 ENOG4105J7D transcriptional regulator DBK22_RS12200 ENOG41088CQ domain protein DBK22_RS12205 ENOG41086DT Membrane protein of unknown function DBK22_RS12210 ENOG41067S9 phage shock protein C, PspC DBK22_RS12215 ENOG4108PY7 DBK22_RS12230 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DBK22_RS12235 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DBK22_RS12250 ENOG4105MKU Transcriptional regulator DBK22_RS12280 ENOG4105CN1 protease DBK22_RS12285 ENOG4108M26 parallel beta-helix repeat protein DBK22_RS12290 ENOG4105CRP Part of the ABC transporter FtsEX involved in DBK22_RS12295 ENOG4105CAK Cell division ATP-binding protein ftsE DBK22_RS12315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DBK22_RS12320 ENOG4105MS2 ribosomal subunit Interface protein DBK22_RS12335 ENOG4105MQ3 flagellar protein FliS DBK22_RS12340 ENOG4107RT6 flagellar hook-associated DBK22_RS12345 ENOG4105I03 Flagellin DBK22_RS12350 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DBK22_RS12355 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DBK22_RS12365 ENOG4105DTJ flagellar hook-associated protein DBK22_RS12370 ENOG4105E1Q flagellar hook-associated protein DBK22_RS12385 ENOG4105RU3 DBK22_RS12390 ENOG41081UC Inherit from COG: Competence protein DBK22_RS12410 ENOG4105WH1 Two component transcriptional regulator luxr family DBK22_RS12415 ENOG4105BZU Histidine kinase DBK22_RS12420 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DBK22_RS12425 ENOG4108KGH TRANSCRIPTIONal DBK22_RS12430 ENOG4105ESV Glycosyl transferase, family 4 DBK22_RS12435 ENOG4107EF8 Glycosyl transferase (Group 1 DBK22_RS12450 ENOG4105QZI O-Antigen Polymerase DBK22_RS12455 ENOG4105C6Y Udp-glucose 6-dehydrogenase DBK22_RS12460 ENOG4107RA4 Glycosyl transferase (Group 1 DBK22_RS12465 ENOG4105PSV Polysaccharide Biosynthesis Protein DBK22_RS12470 ENOG4105D3Q Sugar transferase DBK22_RS12475 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DBK22_RS12480 ENOG4105JFG SpoIID LytB domain protein DBK22_RS12490 ENOG4108KGH TRANSCRIPTIONal DBK22_RS12495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DBK22_RS12500 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DBK22_RS12505 ENOG4105EY8 ABC transporter DBK22_RS12515 ENOG4107SJB teichoic acid biosynthesis DBK22_RS12520 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) DBK22_RS12525 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DBK22_RS12535 ENOG4107RZX Teichoic acid biosynthesis protein DBK22_RS12545 ENOG4105DG6 mannose-6-phosphate isomerase DBK22_RS12560 ENOG4108NHD germination protein DBK22_RS12565 ENOG4107R8N Glycosyl transferase, family 2 DBK22_RS12570 ENOG4105C54 Major Facilitator superfamily DBK22_RS12575 ENOG4108KGH TRANSCRIPTIONal DBK22_RS12580 ENOG4105J7I hydrolase DBK22_RS12585 ENOG4106UBQ DBK22_RS12590 ENOG4105K4H Nlp p60 protein DBK22_RS12600 ENOG4105PNM synthesis protein DBK22_RS12610 ENOG4105N98 Capsule biosynthesis protein capB DBK22_RS12615 ENOG4105E1K spore germination protein DBK22_RS12630 ENOG4105ETE Transcriptional regulator (LacI family DBK22_RS12635 ENOG4108RVA ribokinase DBK22_RS12640 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DBK22_RS12645 ENOG4105C2J ABC transporter DBK22_RS12650 ENOG4105CNN ABC, transporter DBK22_RS12655 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DBK22_RS12665 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DBK22_RS12670 ENOG4107FQX Alpha-acetolactate decarboxylase DBK22_RS12680 ENOG4107RSM transcriptional regulator DBK22_RS12695 ENOG4106UIA DBK22_RS12710 ENOG4107XC4 flavin reductase domain protein, FMN-binding DBK22_RS12720 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DBK22_RS12730 ENOG4105CAH Chromate DBK22_RS12735 ENOG4105FGV Chromate DBK22_RS12770 ENOG4108XI2 Domain of unknown function (DUF1963) DBK22_RS12775 ENOG4105C6Y Udp-glucose 6-dehydrogenase DBK22_RS12780 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DBK22_RS12785 ENOG4107YJ4 chain length determinant protein DBK22_RS12790 ENOG4105HTX biosynthesis protein DBK22_RS12800 ENOG4105KBK Zinc finger, swim domain protein DBK22_RS12805 ENOG4105C0D helicase DBK22_RS12810 ENOG410667J hydrolase DBK22_RS12815 ENOG4105E98 transcriptional regulator DeoR family DBK22_RS12820 ENOG4105Z8H single-stranded DNA-binding protein DBK22_RS12835 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DBK22_RS12840 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DBK22_RS12850 ENOG4105CGA flagellar basal-body rod protein FlgG DBK22_RS12860 ENOG4105DFF Rod shape-determining protein mreb DBK22_RS12865 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DBK22_RS12870 ENOG4107MII Sugar-specific transcriptional regulator TrmB DBK22_RS12875 ENOG4105CZM Major Facilitator DBK22_RS12885 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DBK22_RS12890 ENOG41080V3 Major Facilitator superfamily DBK22_RS12895 ENOG4105D3W isochorismatase DBK22_RS12900 ENOG4105BZU Histidine kinase DBK22_RS12910 ENOG4105CNI cell division protein FtsW DBK22_RS12915 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DBK22_RS12925 ENOG4105FRN stage II sporulation protein DBK22_RS12930 ENOG4107TCE N-acetyltransferase DBK22_RS12945 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DBK22_RS12950 ENOG4106BRK DBK22_RS12955 ENOG4107T94 Endo-14-beta-xylanase DBK22_RS12960 ENOG4108Z40 Transcriptional regulator DBK22_RS12965 ENOG4105CQM Urea amidohydrolase subunit alpha DBK22_RS12970 ENOG4105KI2 Urea amidohydrolase subunit beta DBK22_RS12975 ENOG4108YZ9 Urea amidohydrolase subunit gamma DBK22_RS12995 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DBK22_RS13000 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DBK22_RS13005 ENOG4108TF4 von Willebrand factor, type A DBK22_RS13020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DBK22_RS13030 ENOG4106778 Protein of unknown function (DUF1146) DBK22_RS13040 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DBK22_RS13045 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DBK22_RS13050 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DBK22_RS13055 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DBK22_RS13060 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DBK22_RS13075 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DBK22_RS13085 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DBK22_RS13090 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DBK22_RS13095 ENOG4108UIC UPF0340 protein DBK22_RS13100 ENOG4108YZG isomerase DBK22_RS13105 ENOG4107WAU Protein tyrosine phosphatase DBK22_RS13110 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DBK22_RS13115 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DBK22_RS13125 ENOG4108ZXQ stage ii sporulation protein r DBK22_RS13140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DBK22_RS13145 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DBK22_RS13150 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DBK22_RS13160 ENOG4107TT2 Auxin Efflux Carrier DBK22_RS13165 ENOG4105C6K Malic enzyme DBK22_RS13170 ENOG4107104 thymidine kinase DBK22_RS13175 ENOG41082DI 50s ribosomal protein l31 DBK22_RS13180 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DBK22_RS13185 ENOG4105CBT Fructose-1,6-bisphosphatase DBK22_RS13190 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DBK22_RS13200 ENOG4105D2N Aldolase DBK22_RS13205 ENOG410812K response regulator receiver protein DBK22_RS13215 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DBK22_RS13225 ENOG4105DF6 Fe-S oxidoreductase DBK22_RS13235 ENOG4105E5J UV damage endonuclease DBK22_RS13245 ENOG4105BZ1 (ABC) transporter DBK22_RS13250 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DBK22_RS13265 ENOG4105R3A Nitrate reductase DBK22_RS13270 ENOG4108IUE nitrate reductase beta subunit DBK22_RS13290 ENOG4107V6Q Cyclic nucleotide-binding domain DBK22_RS13300 ENOG4105C75 arginyL-tRNA synthetase DBK22_RS13305 ENOG410684U Domain of unknown function (DUF1934) DBK22_RS13325 ENOG4107JM4 Tetratricopeptide repeat DBK22_RS13370 ENOG4105CYW agmatinase DBK22_RS13375 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DBK22_RS13380 ENOG4105BZ4 penicillin-binding protein DBK22_RS13390 ENOG4108XFG YwhD family DBK22_RS13395 ENOG4108Z4T Peptidase M50 DBK22_RS13400 ENOG41069HH 4-oxalocrotonate tautomerase DBK22_RS13405 ENOG41067TZ transcriptional regulator, MarR family DBK22_RS13410 ENOG4105CUB amino acid DBK22_RS13420 ENOG4105DCI Phosphohydrolase DBK22_RS13430 ENOG4108VCI transcription factor, rsfa family DBK22_RS13435 ENOG4105K7K Transcriptional regulator DBK22_RS13445 ENOG4105CJ1 ABC, transporter DBK22_RS13450 ENOG4108TU7 Inherit from COG: (ABC) transporter DBK22_RS13475 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DBK22_RS13480 ENOG4105DUM transcriptional regulator, lysR family DBK22_RS13485 ENOG4105HMI Membrane DBK22_RS13490 ENOG4108IJ2 phosphate acetyltransferase DBK22_RS13495 ENOG4107JTW chlorite dismutase DBK22_RS13505 ENOG4105CHM Aminotransferase DBK22_RS13535 ENOG4105FCW Major Facilitator superfamily DBK22_RS13540 ENOG4105C2C drug resistance transporter, Bcr CflA DBK22_RS13555 ENOG4105C26 Dehydrogenase DBK22_RS13560 ENOG4105D82 Glutamate dehydrogenase DBK22_RS13570 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase DBK22_RS13575 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DBK22_RS13580 ENOG4105C1B dTDP-glucose 4-6-dehydratase DBK22_RS13585 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DBK22_RS13590 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG DBK22_RS13595 ENOG4107TY6 Acylneuraminate cytidylyltransferase DBK22_RS13605 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD DBK22_RS13610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DBK22_RS13645 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DBK22_RS13650 ENOG4108RJ9 Glycosyl transferase, family 2 DBK22_RS13670 ENOG4105DWF phosphomethylpyrimidine kinase DBK22_RS13685 ENOG4105C5Y PTS System DBK22_RS13700 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DBK22_RS13705 ENOG4105DEN Luciferase family DBK22_RS13710 ENOG4108DBC nitroreductase DBK22_RS13720 ENOG4105I4A GCN5-related N-acetyltransferase DBK22_RS13740 ENOG4105BZ9 Cytochrome C oxidase, subunit I DBK22_RS13745 ENOG4105E2S oxidase) subunit II DBK22_RS13750 ENOG4107BMA Transglycosylase associated protein DBK22_RS13760 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DBK22_RS13765 ENOG4105WH5 Teichoic acid glycosylation protein DBK22_RS13790 ENOG4107ZXU DSBA oxidoreductase DBK22_RS13795 ENOG4105DBE peroxidase DBK22_RS13800 ENOG410650H (LipO)protein DBK22_RS13805 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DBK22_RS13810 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DBK22_RS13815 ENOG4105CMU LysR family (Transcriptional regulator DBK22_RS13820 ENOG4105VAW lrga family DBK22_RS13825 ENOG41067MG lrgb family DBK22_RS13835 ENOG4107TXC Transcriptional regulator DBK22_RS13845 ENOG4105DR4 Methyltransferase DBK22_RS13855 ENOG4105CK1 PTS System DBK22_RS13860 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin DBK22_RS13865 ENOG4105X1N Glycosyl transferase family 8 DBK22_RS13875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DBK22_RS13885 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DBK22_RS13890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DBK22_RS13895 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DBK22_RS13900 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DBK22_RS13905 ENOG4105CM2 brancheD-chain amino acid aminotransferase DBK22_RS13910 ENOG4105F8D glycoside hydrolase family 4 DBK22_RS13915 ENOG4105VCP PTS System DBK22_RS13920 ENOG4105CK1 PTS System DBK22_RS13925 ENOG4105VZJ PTS System DBK22_RS13930 ENOG4105EMD TRANSCRIPTIONal DBK22_RS13940 ENOG4105DQ5 transport system permease protein DBK22_RS13945 ENOG4105EHG Permease protein DBK22_RS13955 ENOG41082YX Transcriptional regulator, arsr family DBK22_RS13960 ENOG4107R5R arsenical pump membrane protein DBK22_RS13965 ENOG4105VZJ PTS System DBK22_RS13970 ENOG4105VCP PTS System DBK22_RS13975 ENOG4105CK1 PTS System DBK22_RS13980 ENOG4105CS2 ec 3.2.1.21 DBK22_RS13985 ENOG4105EVU fructokinase DBK22_RS13990 ENOG4105DG6 mannose-6-phosphate isomerase DBK22_RS14000 ENOG4105CH6 catalase DBK22_RS14005 ENOG4107QHE Choloylglycine hydrolase DBK22_RS14010 ENOG4105ETS cytosine purines uracil thiamine allantoin DBK22_RS14015 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DBK22_RS14020 ENOG4108JJ8 (ABC) transporter DBK22_RS14025 ENOG4108JJ9 ABC, transporter DBK22_RS14030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DBK22_RS14035 ENOG4105C4M (Ubiquinol oxidase) subunit I DBK22_RS14040 ENOG4105D2K citrate carrier protein DBK22_RS14045 ENOG4107BJW polysaccharide deacetylase DBK22_RS14060 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DBK22_RS14070 ENOG4105CMR udp-glucose 4-epimerase DBK22_RS14075 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DBK22_RS14090 ENOG4105DHI Methyltransferase DBK22_RS14110 ENOG4105CH6 catalase DBK22_RS14115 ENOG4105D4T Citrate transporter DBK22_RS14125 ENOG4105CID antiterminator DBK22_RS14130 ENOG4105DEU major facilitator superfamily DBK22_RS14135 ENOG4105C1J atp-dependent rna helicase DBK22_RS14230 ENOG4105CNA YD repeat protein DBK22_RS14235 ENOG4108NR7 pectate lyase DBK22_RS14245 ENOG4107YZX Universal stress protein DBK22_RS14250 ENOG4105CS2 ec 3.2.1.21 DBK22_RS14255 ENOG4105C5Y PTS System DBK22_RS14270 ENOG4106Z5D Glycoside Hydrolase Family 43 DBK22_RS14280 ENOG4105C84 Histidine ammonia-lyase DBK22_RS14285 ENOG4105CGP Urocanate hydratase DBK22_RS14290 ENOG4105CI2 imidazolone-5-propionate hydrolase DBK22_RS14295 ENOG4107W25 arginase agmatinase formiminoglutamase DBK22_RS14305 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DBK22_RS14310 ENOG4105D9N nucleoside DBK22_RS14315 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DBK22_RS14320 ENOG4107RHR regulatoR DBK22_RS14325 ENOG410667J hydrolase DBK22_RS14355 ENOG4108V5C ABC transporter DBK22_RS14390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DBK22_RS14415 ENOG4105WZ4 isomerase DBK22_RS14420 ENOG4105F0H myo-inositol catabolism protein DBK22_RS14425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DBK22_RS14435 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DBK22_RS14445 ENOG4105EDK PfkB domain protein DBK22_RS14455 ENOG4105C26 Dehydrogenase DBK22_RS14465 ENOG4105CPC Aldo Keto reductase DBK22_RS14475 ENOG4107QNK )-transporter DBK22_RS14480 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DBK22_RS14490 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DBK22_RS14495 ENOG4108S01 response regulator DBK22_RS14500 ENOG4108ZGX Histidine kinase DBK22_RS14505 ENOG4105ECK Fatty Acid Desaturase DBK22_RS14510 ENOG4105ST3 Transcriptional regulator DBK22_RS14515 ENOG4105C26 Dehydrogenase DBK22_RS14520 ENOG4108ITS PQQ enzyme repeat DBK22_RS14530 ENOG4105WAB arsR family transcriptional regulator DBK22_RS14535 ENOG4105F27 Major Facilitator DBK22_RS14540 ENOG41085PJ rdd domain containing protein DBK22_RS14550 ENOG4105D3R alkyl hydroperoxide reductase DBK22_RS14555 ENOG4108JU3 Alkyl hydroperoxide reductase DBK22_RS14560 ENOG4107R3N Filamentation induced by cAMP protein fic DBK22_RS14565 ENOG4105C85 amino acid DBK22_RS14570 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DBK22_RS14575 ENOG4108XHQ (2Fe-2S)-binding domain protein DBK22_RS14595 ENOG4105XRQ Xanthine dehydrogenase accessory factor DBK22_RS14680 ENOG4105W5Q DNA repair protein (RadC DBK22_RS14695 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DBK22_RS14710 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) DBK22_RS14715 ENOG4105CPC Aldo Keto reductase DBK22_RS14720 ENOG4105WQG acetyltransferase DBK22_RS14730 ENOG41066UZ arginase EC 3.5.3.1 DBK22_RS14735 ENOG4108IQI permease DBK22_RS14740 ENOG4105C8Y Acetylornithine aminotransferase DBK22_RS14750 ENOG41082BM Transcriptional regulator, arsr family DBK22_RS14755 ENOG4108JUB Transcriptional regulator DBK22_RS14765 ENOG4105C5H ABC transporter DBK22_RS14780 ENOG4105D06 uba thif-type nad fad binding protein DBK22_RS14785 ENOG41062D9 Histidine kinase DBK22_RS14790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS14795 ENOG4105C0H protease DBK22_RS14800 ENOG4105Q2H domain protein DBK22_RS14815 ENOG4105BZU Histidine kinase DBK22_RS14820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS14845 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DBK22_RS14850 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DBK22_RS14855 ENOG4105CDU Replicative dna helicase DBK22_RS14880 ENOG4105EDW glycosyl transferase, family 39 DBK22_RS14895 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DBK22_RS14900 ENOG4105CPK Glycosyl transferase (Group 1 DBK22_RS14920 ENOG4105BZR domain protein DBK22_RS14925 ENOG4108XMW Membrane DBK22_RS14940 ENOG4105KVH Transcriptional regulator DBK22_RS14945 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DBK22_RS14950 ENOG4108UZ3 Transporter DBK22_RS14955 ENOG4105EDQ levansucrase EC 2.4.1.10 DBK22_RS14960 ENOG4108HKT sucrose-6-phosphate hydrolase DBK22_RS14965 ENOG4107XBN GntR Family Transcriptional Regulator DBK22_RS14980 ENOG4107V2S Transcriptional regulator DBK22_RS14985 ENOG4108VP3 Lysine exporter protein (LysE YggA) DBK22_RS14990 ENOG4105D94 Major Facilitator Superfamily DBK22_RS14995 ENOG4107RSM transcriptional regulator DBK22_RS15005 ENOG4108TVJ Nitroreductase DBK22_RS15010 ENOG4105FS7 Transcriptional regulator DBK22_RS15020 ENOG4108U05 Transcriptional regulator DBK22_RS15025 ENOG41082BV acetyltransferase DBK22_RS15035 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DBK22_RS15040 ENOG4105CMU LysR family (Transcriptional regulator DBK22_RS15045 ENOG4105DTD Dehydrogenase DBK22_RS15055 ENOG4107Y9U Membrane DBK22_RS15060 ENOG4105C7Z Conserved Protein DBK22_RS15065 ENOG4107FCW Abortive infection protein DBK22_RS15075 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DBK22_RS15085 ENOG4105CGK Exodeoxyribonuclease III DBK22_RS15090 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DBK22_RS15100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DBK22_RS15105 ENOG4108UUM single-stranded DNA-binding protein DBK22_RS15110 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DBK22_RS15115 ENOG4105C3G gtp-binding protein DBK22_RS15120 ENOG4108J2R molybdopterin oxidoreductase DBK22_RS15125 ENOG4105VDK protein, conserved in bacteria DBK22_RS15140 ENOG4108ZDA Sporulation protein YyaC DBK22_RS15145 ENOG4105FA0 parb-like partition protein DBK22_RS15150 ENOG4107QJE Chromosome Partitioning Protein DBK22_RS15165 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DBK22_RS15170 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DBK22_RS15185 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DBK22_RS15195 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DBK22_RS15200 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DBK22_RS15205 ENOG410848D S4 domain protein YaaA DBK22_RS15210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DBK22_RS15220 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DBK22_RS15225 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DBK22_RS15260 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DBK22_RS15270 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DBK22_RS15275 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DBK22_RS15280 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DBK22_RS15285 ENOG4105BZW Glycerate kinase DBK22_RS15295 ENOG4105ZMH deoxynucleoside kinase DBK22_RS15305 ENOG4105VRS hydrolase family 18 DBK22_RS15310 ENOG4105GTG Isochorismatase DBK22_RS15315 ENOG4108Z6B deaminase DBK22_RS15325 ENOG4105C6E dna polymerase iii DBK22_RS15330 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DBK22_RS15335 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DBK22_RS15345 ENOG41067KS pro-sigma K processing DBK22_RS15385 ENOG4105CDW Resistance protein DBK22_RS15390 ENOG4105CXN decarboxylase DBK22_RS15395 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DBK22_RS15400 ENOG4105X0R protein from nitrogen regulatory protein P-II DBK22_RS15405 ENOG4105XVJ Protein of unknown function (DUF327) DBK22_RS15410 ENOG4105FA2 dna polymerase iii DBK22_RS15415 ENOG4105MA4 psp1 domain protein DBK22_RS15425 ENOG41060K3 Methyltransferase DBK22_RS15430 ENOG4105VC4 domain protein DBK22_RS15435 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DBK22_RS15440 ENOG4105KRN Transcriptional regulator, abrb family DBK22_RS15445 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DBK22_RS15450 ENOG4105F8V Hydrolase, tatD family DBK22_RS15455 ENOG41069ER domain protein DBK22_RS15465 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DBK22_RS15470 ENOG4105XFA sporulation peptidase YabG DBK22_RS15475 ENOG4105W42 Veg protein DBK22_RS15480 ENOG4105XEW small acid-soluble spore protein DBK22_RS15485 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DBK22_RS15490 ENOG4105DFT pur operon repressor DBK22_RS15495 ENOG4105KME endoribonuclease L-psp DBK22_RS15500 ENOG4105K4W Could be involved in septation (By similarity) DBK22_RS15505 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DBK22_RS15510 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DBK22_RS15515 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DBK22_RS15530 ENOG4108JA2 transcriptioN-repair coupling factor DBK22_RS15535 ENOG4108M14 stage v sporulation protein t DBK22_RS15545 ENOG4108IY2 MazG family DBK22_RS15550 ENOG41082I2 s4 domain protein DBK22_RS15555 ENOG4105VYY sporulation protein yabp DBK22_RS15570 ENOG41060GV RNA binding s1 domain protein DBK22_RS15600 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DBK22_RS15605 ENOG4108UGV hypoxanthine phosphoribosyltransferase DBK22_RS15610 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DBK22_RS15615 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DBK22_RS15620 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DBK22_RS15625 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DBK22_RS15630 ENOG4105C6T cysteine synthase DBK22_RS15635 ENOG4105CRQ synthase (Component I) DBK22_RS15640 ENOG4105DDQ anthranilate synthase DBK22_RS15645 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DBK22_RS15650 ENOG4105EEI dihydropteroate synthase DBK22_RS15655 ENOG4105KRF dihydroneopterin aldolase DBK22_RS15660 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DBK22_RS15670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DBK22_RS15675 ENOG4105CRK lysyL-tRNA synthetase DBK22_RS15760 ENOG4108Z0C Uvrb UvrC protein DBK22_RS15765 ENOG41066A3 ATP guanido phosphotransferase DBK22_RS15775 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DBK22_RS15780 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DBK22_RS15785 ENOG4105CTP PilT protein domain protein DBK22_RS15790 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DBK22_RS15795 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DBK22_RS15800 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DBK22_RS15805 ENOG4105D7W serine acetyltransferase DBK22_RS15815 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DBK22_RS15820 ENOG4105C2N RNA methyltransferase TrmH family group 3 DBK22_RS15825 ENOG4105M0M Tetracycline resistance protein DBK22_RS15845 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DBK22_RS15850 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DBK22_RS15860 ENOG4108VZM 50s ribosomal protein L10 DBK22_RS15865 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DBK22_RS15870 ENOG4107Y49 methyltransferase DBK22_RS15875 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DBK22_RS15880 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DBK22_RS15885 ENOG4105XPM ribosomal protein DBK22_RS15890 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DBK22_RS15895 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DBK22_RS15900 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DBK22_RS15905 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DBK22_RS15910 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DBK22_RS15915 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DBK22_RS15920 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DBK22_RS15925 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DBK22_RS15930 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DBK22_RS15935 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DBK22_RS15940 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DBK22_RS15945 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DBK22_RS15950 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DBK22_RS15955 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DBK22_RS15960 ENOG41082SA 50s ribosomal protein l29 DBK22_RS15965 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DBK22_RS15980 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DBK22_RS15990 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DBK22_RS15995 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DBK22_RS16000 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DBK22_RS16005 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DBK22_RS16010 ENOG4105VPB 50S ribosomal protein L30 DBK22_RS16015 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DBK22_RS16020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DBK22_RS16025 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DBK22_RS16030 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DBK22_RS16040 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DBK22_RS16050 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DBK22_RS16055 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DBK22_RS16060 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DBK22_RS16065 ENOG4108ZT0 50S ribosomal protein l17 DBK22_RS16070 ENOG4108JJB ABC transporter DBK22_RS16075 ENOG4108JJB ABC transporter DBK22_RS16080 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DBK22_RS16085 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DBK22_RS16090 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DBK22_RS16095 ENOG4108UJD 30S ribosomal protein S9 DBK22_RS16100 ENOG4108I0C methyltransferase DBK22_RS16120 ENOG4105D1F ATP-binding protein DBK22_RS16135 ENOG4108NMV polysaccharide deacetylase DBK22_RS16200 ENOG4108JPW Aminotransferase DBK22_RS16215 ENOG4105CHH sulfate transporter DBK22_RS16225 ENOG4108SA1 esterase DBK22_RS16245 ENOG410874W AraC family transcriptional regulator DBK22_RS16250 ENOG4105EHZ conserved protein UCP016719 DBK22_RS16255 ENOG4105D17 glycoside hydrolase, family 3 domain protein DBK22_RS16270 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DBK22_RS16280 ENOG4105EWC Purine nucleoside phosphorylase DBK22_RS16310 ENOG4105EMN RNA polymerase sigma factor DBK22_RS16320 ENOG4105C8B TIGR00159 family DBK22_RS16325 ENOG4107U5W ybbr family DBK22_RS16330 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DBK22_RS16355 ENOG4106K80 DBK22_RS16365 ENOG41067MG lrgb family DBK22_RS16375 ENOG41061AU MarR family Transcriptional regulator DBK22_RS16390 ENOG4105BZU Histidine kinase DBK22_RS16395 ENOG4105WH1 Two component transcriptional regulator luxr family DBK22_RS16400 ENOG4105CJ1 ABC, transporter DBK22_RS16440 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS16445 ENOG4105C0W non-ribosomal peptide synthetase DBK22_RS16470 ENOG4106DDH Sporulation-specific SASP protein DBK22_RS16485 ENOG4107QTZ amino acid DBK22_RS16495 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DBK22_RS16500 ENOG4105CXY transporter DBK22_RS16535 ENOG41065RQ ADP-ribosylation crystallin J1 DBK22_RS16540 ENOG4106BHF DBK22_RS16550 ENOG4107SCQ Iron-containing alcohol dehydrogenase DBK22_RS16555 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DBK22_RS16560 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DBK22_RS16565 ENOG4107ZTW SNARE associated Golgi DBK22_RS16580 ENOG4105C72 UPF0176 protein DBK22_RS16590 ENOG4105CM2 brancheD-chain amino acid aminotransferase DBK22_RS16595 ENOG4108IQI permease DBK22_RS16600 ENOG4108J5H Homocysteine s-methyltransferase DBK22_RS16610 ENOG4105CSV Glutaminase DBK22_RS16635 ENOG41076HS cation diffusion facilitator family transporter DBK22_RS16640 ENOG4108TVJ Nitroreductase DBK22_RS16645 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DBK22_RS16650 ENOG4108VGI doxx family DBK22_RS16655 ENOG4105XXY Thioredoxin DBK22_RS16670 ENOG4105DGI Alkaline phosphatase DBK22_RS16675 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DBK22_RS16680 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DBK22_RS16685 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DBK22_RS16690 ENOG4107EPV Aminotransferase class V DBK22_RS16695 ENOG4105C0R drug resistance transporter emrb qaca subfamily DBK22_RS16700 ENOG4105J7D transcriptional regulator DBK22_RS16705 ENOG4107RB3 L-asparaginase DBK22_RS16710 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DBK22_RS16715 ENOG41060AI SEC-C motif DBK22_RS16720 ENOG4107SET aldo keto reductase DBK22_RS16750 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DBK22_RS16760 ENOG4105DSE periplasmic solute binding protein DBK22_RS16765 ENOG4105DIK (ABC) transporter DBK22_RS16775 ENOG4105DEN Luciferase family DBK22_RS16780 ENOG4108N0M stress protein DBK22_RS16785 ENOG4106FN3 tellurium resistance protein DBK22_RS16790 ENOG4106FN3 tellurium resistance protein DBK22_RS16795 ENOG4107TS3 membrane protein, TerC DBK22_RS16800 ENOG4108TTB tellurium resistance protein DBK22_RS16810 ENOG41079KZ Major Facilitator Superfamily DBK22_RS16815 ENOG4108IJ7 Glycine betaine DBK22_RS16820 ENOG4107SQ8 Glycine betaine DBK22_RS16850 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DBK22_RS16880 ENOG4105EIG urea carboxylase-associated protein 1 DBK22_RS16885 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DBK22_RS16895 ENOG4105I1F Resistance protein DBK22_RS16900 ENOG4108WBH protein TIM barrel DBK22_RS16905 ENOG4105DJB Major Facilitator Superfamily DBK22_RS16910 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DBK22_RS16915 ENOG4105I82 acetyl xylan esterase DBK22_RS16920 ENOG410756H nucleotidyltransferase DBK22_RS16930 ENOG4105C26 Dehydrogenase DBK22_RS16935 ENOG4105CK7 Sodium proline symporter DBK22_RS16940 ENOG4107YHD transcriptional regulator DBK22_RS16945 ENOG4105CAY ferredoxin--nadp reductase DBK22_RS16950 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DBK22_RS16955 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DBK22_RS16960 ENOG4108IFG nitrite reductase, (NAD(P)H) DBK22_RS16965 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DBK22_RS16980 ENOG4105CKI cobalamin synthesis protein DBK22_RS16985 ENOG4105E2A Dehydrogenase DBK22_RS16990 ENOG4105HHM rdd domain containing protein DBK22_RS17000 ENOG4105CS2 ec 3.2.1.21 DBK22_RS17015 ENOG41080HJ 6-phospho 3-hexuloisomerase DBK22_RS17020 ENOG4108VA3 3-hexulose-6-phosphate synthase DBK22_RS17025 ENOG4105KVH Transcriptional regulator DBK22_RS17030 ENOG4105CEY Amp-dependent synthetase and ligase DBK22_RS17050 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DBK22_RS17060 ENOG4105SX7 Transporter DBK22_RS17080 ENOG4105CDA abc transporter atp-binding protein DBK22_RS17085 ENOG4105DRP amino acid AbC transporter DBK22_RS17095 ENOG4106P55 Transcriptional regulator DBK22_RS17100 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DBK22_RS17105 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DBK22_RS17110 ENOG41069ZX DBK22_RS17115 ENOG41069ZX DBK22_RS17120 ENOG4105DUX Transporter DBK22_RS17135 ENOG4105E1K spore germination protein DBK22_RS17150 ENOG4105CPU Monooxygenase DBK22_RS17155 ENOG4108XSB acetyltransferase, (GNAT) family DBK22_RS17160 ENOG4105EAB amino acid AbC transporter DBK22_RS17165 ENOG4108HW4 amino acid AbC transporter DBK22_RS17175 ENOG4105CH2 amidohydrolase DBK22_RS17180 ENOG4108PGP mmge prpd family protein DBK22_RS17190 ENOG4107WD8 ABC transporter, permease DBK22_RS17195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS17200 ENOG4105BZU Histidine kinase DBK22_RS17220 ENOG4105CFH Aspartokinase DBK22_RS17225 ENOG4105DHS permease protein DBK22_RS17230 ENOG4105CM4 permease protein DBK22_RS17235 ENOG4108IPW abc transporter atp-binding protein DBK22_RS17250 ENOG4105R8C Transcriptional regulator DBK22_RS17255 ENOG4108DBC nitroreductase DBK22_RS17260 ENOG41067V3 Antibiotic biosynthesis monooxygenase DBK22_RS17265 ENOG4105YVS arsR family transcriptional regulator DBK22_RS17275 ENOG4108JPW Aminotransferase DBK22_RS17280 ENOG4105C26 Dehydrogenase DBK22_RS17295 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DBK22_RS17300 ENOG4105KTB nuclear export factor GLE1 DBK22_RS17305 ENOG4108T5E Copper resistance protein DBK22_RS17310 ENOG4108ZYE Transcriptional regulator DBK22_RS17330 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DBK22_RS17350 ENOG4105E7W lamb ycsf family protein DBK22_RS17355 ENOG4105C5A transporter DBK22_RS17360 ENOG4105CFM UPF0317 protein DBK22_RS17365 ENOG4105P4J Allophanate hydrolase, subunit 1 DBK22_RS17375 ENOG4107258 Transcriptional regulator DBK22_RS17380 ENOG4105XJB lipolytic protein G-D-S-L family DBK22_RS17390 ENOG41061CK Antibiotic biosynthesis monooxygenase DBK22_RS17395 ENOG4107RVG penicillin-binding protein DBK22_RS17405 ENOG4105ETD TRANSCRIPTIONal DBK22_RS17415 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DBK22_RS17430 ENOG410606W general stress protein DBK22_RS17445 ENOG4105VCH membrane DBK22_RS17455 ENOG4105C9U ATP-dependent DNA helicase RecQ DBK22_RS17470 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DBK22_RS17475 ENOG4107R8N Glycosyl transferase, family 2 DBK22_RS17485 ENOG4105C0X amino acid DBK22_RS17520 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DBK22_RS17530 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DBK22_RS17535 ENOG4105RXJ DBK22_RS17540 ENOG4105KPY Small multidrug resistance protein DBK22_RS17545 ENOG4105EU9 DBK22_RS17550 ENOG4105QVS general stress protein DBK22_RS17555 ENOG41082W1 Cupin 2, conserved barrel domain protein DBK22_RS17570 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DBK22_RS17575 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DBK22_RS17580 ENOG4108MRH transcriptional regulatory protein DBK22_RS17585 ENOG4107QJT sodium dicarboxylate symporter DBK22_RS17590 ENOG4106F5Q Membrane DBK22_RS17595 ENOG4105CJ1 ABC, transporter DBK22_RS17610 ENOG4105FDT acyl-CoA dehydrogenase DBK22_RS17630 ENOG4105SZ6 Thioredoxin DBK22_RS17635 ENOG4105CPF Cell wall formation (By similarity) DBK22_RS17640 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DBK22_RS17645 ENOG4105C1J atp-dependent rna helicase DBK22_RS17650 ENOG410905X membrane-flanked domain protein DBK22_RS17655 ENOG4105CKV Membrane DBK22_RS17665 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DBK22_RS17670 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DBK22_RS17675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DBK22_RS17685 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DBK22_RS17690 ENOG4107MMM Anti-sigma-factor antagonist DBK22_RS17695 ENOG4105FUA antagonist DBK22_RS17700 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DBK22_RS17705 ENOG4107SGM protein serine threonine phosphatase DBK22_RS17710 ENOG4105WN5 stage II sporulation protein DBK22_RS17715 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DBK22_RS17725 ENOG41064BQ Phosphatase DBK22_RS17740 ENOG410906U SprT-like DBK22_RS17805 ENOG410847I Transcriptional regulator, BadM Rrf2 family DBK22_RS17810 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DBK22_RS17815 ENOG4105ECP epimerase DBK22_RS17820 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DBK22_RS17835 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DBK22_RS17845 ENOG4105C94 Transporter DBK22_RS17850 ENOG4105CSH Transporter DBK22_RS17855 ENOG4105K56 Transcriptional regulator DBK22_RS17865 ENOG4108ZMQ domain protein DBK22_RS17880 ENOG4108Z40 Transcriptional regulator DBK22_RS17885 ENOG4108RYK Nad-dependent epimerase dehydratase DBK22_RS17890 ENOG4105ECK Fatty Acid Desaturase DBK22_RS17900 ENOG4105VEQ Cold shock protein DBK22_RS17905 ENOG4108VJ1 Transcriptional regulator (CarD family DBK22_RS17925 ENOG410645S MarR family Transcriptional regulator DBK22_RS17930 ENOG4105DCM major facilitator superfamily DBK22_RS17935 ENOG4105IRW patatin-like phospholipase family protein DBK22_RS17945 ENOG41082W1 Cupin 2, conserved barrel domain protein DBK22_RS17960 ENOG4105DNP FAD linked oxidase domain protein DBK22_RS17970 ENOG4105PGM cation diffusion facilitator family transporter DBK22_RS17975 ENOG4105H3G oxidoreductase DBK22_RS17985 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein DBK22_RS17995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DBK22_RS18020 ENOG4105DQ4 alcohol dehydrogenase DBK22_RS18025 ENOG4105VUF Transcriptional regulator DBK22_RS18035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS18050 ENOG4105EQ0 Major Facilitator superfamily DBK22_RS18055 ENOG4108JGH Tetr family transcriptional regulator DBK22_RS18060 ENOG4105T38 integral membrane protein DBK22_RS18065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DBK22_RS18080 ENOG4105E2A Dehydrogenase DBK22_RS18085 ENOG4105PGS Spore coat protein DBK22_RS18100 ENOG4108VB1 regulatoR DBK22_RS18105 ENOG4105EYF MMPL domain protein DBK22_RS18125 ENOG4108JYZ YitT family DBK22_RS18135 ENOG4105C2C drug resistance transporter, Bcr CflA DBK22_RS18140 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DBK22_RS18170 ENOG4105F2W methyltransferase DBK22_RS18175 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DBK22_RS18180 ENOG4105DRR Transcriptional regulator, GntR family DBK22_RS18200 ENOG4105FQP Beta-lactamase DBK22_RS18205 ENOG41090UD (LipO)protein DBK22_RS18210 ENOG4108SUT Major Facilitator Superfamily DBK22_RS18215 ENOG4108TZY GntR Family Transcriptional Regulator DBK22_RS18220 ENOG4105JXH GntR family transcriptional regulator DBK22_RS18225 ENOG4105DJ2 Major Facilitator Superfamily DBK22_RS18245 ENOG4107QTZ amino acid DBK22_RS18265 ENOG4107QNK )-transporter DBK22_RS18305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DBK22_RS18310 ENOG4105K8N protein family UPF0079, ATPase DBK22_RS18315 ENOG41072GX Peptidase M22 Glycoprotease DBK22_RS18320 ENOG410801F ribosomal-protein-alanine acetyltransferase DBK22_RS18325 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DBK22_RS18330 ENOG4105C5H ABC transporter DBK22_RS18335 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DBK22_RS18340 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DBK22_RS18345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DBK22_RS18350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DBK22_RS18360 ENOG4108TYN CAAX amino terminal protease family protein DBK22_RS18365 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DBK22_RS18370 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DBK22_RS18375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DBK22_RS18390 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DBK22_RS18420 ENOG4108JJA ABC, transporter DBK22_RS18470 ENOG4105PGZ NB-ARC domain DBK22_RS18475 ENOG4105CPQ Dehydrogenase DBK22_RS18480 ENOG4105CT4 transporter DBK22_RS18495 ENOG41087YS Phage shock protein A DBK22_RS18500 ENOG4105DQX Zinc finger domain DBK22_RS18505 ENOG4108WV1 Pfam:DUF477 DBK22_RS18515 ENOG4105EXC Acyl-transferase DBK22_RS18520 ENOG4108P49 AntiSigma factor DBK22_RS18525 ENOG4105JVQ RNA Polymerase DBK22_RS18550 ENOG4107STQ Multicopper oxidase DBK22_RS18555 ENOG4105C85 amino acid DBK22_RS18565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DBK22_RS18580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DBK22_RS18595 ENOG4105C7N Xanthine uracil vitamin C permease DBK22_RS18620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DBK22_RS18625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DBK22_RS18630 ENOG4105C83 adenylosuccinate lyase DBK22_RS18635 ENOG4105C8V SAICAR synthetase DBK22_RS18640 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DBK22_RS18645 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DBK22_RS18650 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DBK22_RS18660 ENOG4105CXB phosphoribosylaminoimidazole synthetase DBK22_RS18665 ENOG4108V3E phosphoribosylglycinamide formyltransferase DBK22_RS18670 ENOG4105DC1 bifunctional purine biosynthesis protein purh DBK22_RS18675 ENOG4105C12 Phosphoribosylglycinamide synthetase DBK22_RS18690 ENOG4108R5T secreted protein DBK22_RS18695 ENOG4105KGF protein, YerC YecD DBK22_RS18700 ENOG4105CBC glutamate synthase DBK22_RS18710 ENOG4105C4R Atp-dependent dna helicase DBK22_RS18715 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DBK22_RS18725 ENOG4105CRN Aminoglycoside phosphotransferase DBK22_RS18730 ENOG4105KT7 mgtC SapB transporter DBK22_RS18735 ENOG4105CK7 Sodium proline symporter DBK22_RS18740 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DBK22_RS18745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DBK22_RS18750 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DBK22_RS18755 ENOG4108IG5 Transcriptional regulator DBK22_RS18765 ENOG4105CBD Diacylglycerol kinase DBK22_RS18770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DBK22_RS18780 ENOG4105CJ1 ABC, transporter DBK22_RS18815 ENOG4105CDY transcriptional regulatory protein DBK22_RS18835 ENOG4105WEF catalase DBK22_RS18840 ENOG4105M18 -acetyltransferase DBK22_RS18850 ENOG4105H67 Protein of unknown function (DUF421) DBK22_RS18860 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DBK22_RS18865 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DBK22_RS18885 ENOG4106I4J membrane DBK22_RS18890 ENOG41082F9 transcriptional regulator DBK22_RS18895 ENOG41061H0 Monooxygenase DBK22_RS18900 ENOG4108R1P DBK22_RS18905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DBK22_RS18920 ENOG4105CJ1 ABC, transporter DBK22_RS18930 ENOG4105E0M Sulfatase DBK22_RS18935 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DBK22_RS18945 ENOG41090R9 glycosyltransferase DBK22_RS18950 ENOG4107R51 Glycosyl transferase, family 2 DBK22_RS18955 ENOG41090R9 glycosyltransferase DBK22_RS18960 ENOG4105EU0 Major facilitator Superfamily DBK22_RS18965 ENOG4105CUB amino acid DBK22_RS18970 ENOG4105C26 Dehydrogenase DBK22_RS18975 ENOG4105FKZ Methyl-accepting chemotaxis DBK22_RS18980 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DBK22_RS18985 ENOG4107TVC Glycosyl transferase, family 2 DBK22_RS18990 ENOG4105C5H ABC transporter DBK22_RS18995 ENOG4107SWG transcriptional regulator MERR family DBK22_RS19000 ENOG4105DXB Major Facilitator superfamily DBK22_RS19005 ENOG4105C5H ABC transporter DBK22_RS19010 ENOG4105FDU atp-dependent rna helicase DBK22_RS19020 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DBK22_RS19035 ENOG4108J20 pectate lyase DBK22_RS19040 ENOG4107QPK )-transporter DBK22_RS19065 ENOG4108VAC response regulator DBK22_RS19075 ENOG4108Z6X (sortase) family DBK22_RS19085 ENOG4108MRH transcriptional regulatory protein DBK22_RS19110 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) DBK22_RS19115 ENOG4108RPX mosc domain containing protein DBK22_RS19135 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DBK22_RS19175 ENOG4105C5Y PTS System DBK22_RS19180 ENOG4105CG3 alpha amylase, catalytic region DBK22_RS19185 ENOG4107414 GntR family transcriptional regulator DBK22_RS19190 ENOG4108RCM Nitroreductase DBK22_RS19205 ENOG4105CGH 5'-nucleotidase DBK22_RS19210 ENOG4107RKG DJ-1/PfpI family DBK22_RS19215 ENOG4105ETE Transcriptional regulator (LacI family DBK22_RS19220 ENOG4105E2X shikimate dehydrogenase DBK22_RS19225 ENOG4105FF2 Type I DHQase DBK22_RS19240 ENOG4105KJF protein tyrosine phosphatase DBK22_RS19250 ENOG4107U9T Pfam:Ribonuclease_BN DBK22_RS19255 ENOG4108ISG Major Facilitator DBK22_RS19260 ENOG4105UPD Calcium Proton DBK22_RS19270 ENOG4105D8X mechanosensitive ion channel DBK22_RS19290 ENOG4106KE4 Dehydrogenase DBK22_RS19300 ENOG4105D7N magnesium and cobalt transport protein CorA DBK22_RS19310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DBK22_RS19330 ENOG4107RUY (E1 component), alpha subunit DBK22_RS19340 ENOG4107QKR Dehydrogenase DBK22_RS19350 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DBK22_RS19360 ENOG4105F8D glycoside hydrolase family 4 DBK22_RS19365 ENOG4108Q3X Transcriptional regulator DBK22_RS19370 ENOG4105CI1 PTS System DBK22_RS19380 ENOG4105BZ1 (ABC) transporter DBK22_RS19385 ENOG4105BZ1 (ABC) transporter DBK22_RS19395 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DBK22_RS19400 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DBK22_RS19405 ENOG4105U3E Transcriptional regulator DBK22_RS19410 ENOG4105DYS nad(p)h dehydrogenase (quinone) DBK22_RS19415 ENOG4105H93 Acyltransferase family DBK22_RS19430 ENOG4108YYS metal-dependent hydrolase (By similarity) DBK22_RS19435 ENOG4105C0R drug resistance transporter emrb qaca subfamily DBK22_RS19440 ENOG410834F Transcriptional regulator DBK22_RS19450 ENOG4105JAB phenazine biosynthesis protein, phzf family DBK22_RS19455 ENOG4107Y03 Nitroreductase DBK22_RS19470 ENOG4105ECP epimerase DBK22_RS19475 ENOG410902V Modulates RecA activity (By similarity) DBK22_RS19485 ENOG4105F27 Major Facilitator DBK22_RS19495 ENOG4108TCS Glutamyl endopeptidase DBK22_RS19515 ENOG4106AKJ DBK22_RS19520 ENOG4105D74 hydrolase DBK22_RS19525 ENOG4105CKK Glycosyl transferase, family 2 DBK22_RS19530 ENOG4105EJV Membrane DBK22_RS19535 ENOG41067AE Membrane-bound metal-dependent hydrolase DBK22_RS19540 ENOG4105CEN a g-specific adenine glycosylase DBK22_RS19545 ENOG4106BXE DBK22_RS19550 ENOG4105CAN Short-chain dehydrogenase reductase Sdr