locus-tag	class	description
ES966_RS00010	COG0592	DNA-directed DNA polymerase activity
ES966_RS00015	COG2501	S4 domain
ES966_RS00030	COG0187	DNA topoisomerase II activity
ES966_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES966_RS00070	COG0516	GMP reductase activity
ES966_RS00070	COG0517	IMP dehydrogenase activity
ES966_RS00075	COG1686	Belongs to the peptidase S11 family
ES966_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
ES966_RS00105	COG1428	Deoxynucleoside kinase
ES966_RS00110	COG1428	Deoxynucleoside kinase
ES966_RS00115	COG1388	LysM domain
ES966_RS00115	COG3858	chitin binding
ES966_RS00120	COG1335	isochorismatase
ES966_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES966_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES966_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES966_RS00195	COG3853	Toxic anion resistance protein (TelA)
ES966_RS00200	COG1982	Orn Lys Arg decarboxylase major
ES966_RS00210	COG3870	Protein conserved in bacteria
ES966_RS00215	COG1728	Protein conserved in bacteria
ES966_RS00220	COG0470	DNA polymerase III
ES966_RS00225	COG1774	PSP1 C-terminal conserved region
ES966_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES966_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES966_RS00250	COG2002	toxin-antitoxin pair type II binding
ES966_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_RS00260	COG0084	hydrolase, TatD family'
ES966_RS00265	COG3583	domain protein
ES966_RS00265	COG3584	3D domain protein
ES966_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES966_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES966_RS00285	COG4466	Protein conserved in bacteria
ES966_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES966_RS00305	COG0251	oxidation-reduction process
ES966_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES966_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES966_RS00345	COG2002	toxin-antitoxin pair type II binding
ES966_RS00350	COG2244	polysaccharide biosynthetic process
ES966_RS00355	COG3956	TIGRFAM MazG family protein
ES966_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES966_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES966_RS00380	COG1098	S1 RNA binding domain
ES966_RS00395	COG2208	phosphoserine phosphatase activity
ES966_RS00400	COG2304	oxidoreductase activity
ES966_RS00405	COG0515	serine threonine protein kinase
ES966_RS00410	COG0037	tRNA processing
ES966_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ES966_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES966_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES966_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES966_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
ES966_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES966_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES966_RS00475	COG1396	sequence-specific DNA binding
ES966_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES966_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES966_RS00565	COG4463	regulation of RNA biosynthetic process
ES966_RS00570	COG3880	PFAM UvrB UvrC protein
ES966_RS00580	COG0542	response to heat
ES966_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES966_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES966_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
ES966_RS00615	COG1045	serine acetyltransferase
ES966_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES966_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES966_RS00635	COG3688	RNA-binding protein containing a PIN domain
ES966_RS00640	COG1595	DNA-templated transcription, initiation
ES966_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES966_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
ES966_RS00680	COG2813	Specifically methylates the guanine in position
ES966_RS00695	COG1358	cellular component organization or biogenesis
ES966_RS00720	COG0596	Alpha beta hydrolase
ES966_RS00830	COG0201	protein transport
ES966_RS00840	COG0024	Methionine aminopeptidase
ES966_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES966_RS00880	COG1122	ATPase activity
ES966_RS00885	COG1122	ATPase activity
ES966_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES966_RS00910	COG2226	methyltransferase
ES966_RS00915	COG2318	DinB family
ES966_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_RS00930	COG0489	protein tyrosine kinase activity
ES966_RS00940	COG2194	sulfuric ester hydrolase activity
ES966_RS00945	COG0726	polysaccharide deacetylase
ES966_RS01005	COG0738	Major facilitator superfamily
ES966_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES966_RS01020	COG1063	alcohol dehydrogenase
ES966_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
ES966_RS01030	COG0385	Bile acid
ES966_RS01035	COG2819	hydrolase of the alpha beta superfamily
ES966_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_RS01055	COG2207	Transcriptional regulator
ES966_RS01060	COG3876	Protein conserved in bacteria
ES966_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ES966_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_RS01075	COG1263	PTS System
ES966_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_RS01090	COG1683	Conserved Protein
ES966_RS01120	COG1595	DNA-templated transcription, initiation
ES966_RS01125	COG5662	AntiSigma factor
ES966_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES966_RS01135	COG4856	YbbR-like protein
ES966_RS01175	COG1063	alcohol dehydrogenase
ES966_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS01225	COG1346	cytolysis
ES966_RS01230	COG1380	Effector of murein hydrolase LrgA
ES966_RS01235	COG1846	Transcriptional regulator
ES966_RS01240	COG1113	amino acid transport
ES966_RS01245	COG1011	Hydrolase
ES966_RS01250	COG4585	Histidine kinase
ES966_RS01255	COG2197	response regulator
ES966_RS01260	COG1131	(ABC) transporter
ES966_RS01300	COG0531	amino acid
ES966_RS01325	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_RS01330	COG2271	Major facilitator Superfamily
ES966_RS01345	COG2368	4-hydroxyphenylacetate
ES966_RS01355	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS01370	COG0371	Dehydrogenase
ES966_RS01380	COG1183	phosphatidylcholine synthase activity
ES966_RS01385	COG0586	Pfam SNARE associated Golgi protein
ES966_RS01390	COG0688	phosphatidylethanolamine metabolic process
ES966_RS01405	COG1301	dicarboxylic acid transport
ES966_RS01410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_RS01415	COG0833	amino acid
ES966_RS01420	COG2040	homocysteine
ES966_RS01425	COG1115	amino acid carrier protein
ES966_RS01430	COG2066	Belongs to the glutaminase family
ES966_RS01435	COG4191	Histidine kinase
ES966_RS01440	COG0784	Response regulator, receiver
ES966_RS01465	COG3773	Cell wall hydrolase
ES966_RS01475	COG3540	Alkaline phosphatase
ES966_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES966_RS01485	COG0805	protein transport
ES966_RS01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES966_RS01500	COG0477	Major facilitator Superfamily
ES966_RS01505	COG1309	transcriptional regulator
ES966_RS01510	COG0252	asparaginase activity
ES966_RS01515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES966_RS01520	COG1405	negative regulation of cell septum assembly
ES966_RS01520	COG3012	SEC-C Motif Domain Protein
ES966_RS01525	COG0667	Aldo Keto reductase
ES966_RS01535	COG1595	DNA-templated transcription, initiation
ES966_RS01540	COG1595	DNA-templated transcription, initiation
ES966_RS01545	COG1876	peptidase activity
ES966_RS01550	COG0457	Tetratricopeptide repeat
ES966_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS01575	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES966_RS01580	COG1121	(ABC) transporter
ES966_RS01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_RS01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS01595	COG2310	stress, protein
ES966_RS01600	COG2310	stress, protein
ES966_RS01605	COG2310	stress, protein
ES966_RS01610	COG0861	Integral membrane protein TerC family
ES966_RS01620	COG3853	Toxic anion resistance protein (TelA)
ES966_RS01625	COG0477	Major facilitator Superfamily
ES966_RS01630	COG0517	IMP dehydrogenase activity
ES966_RS01630	COG4175	Glycine betaine
ES966_RS01635	COG4176	ABC-type proline glycine betaine transport system permease component
ES966_RS01640	COG2113	Glycine betaine
ES966_RS01645	COG1473	amidohydrolase
ES966_RS01650	COG1288	antiporter activity
ES966_RS01660	COG0366	Alpha amylase catalytic
ES966_RS01670	COG2814	Major facilitator Superfamily
ES966_RS01675	COG1846	Transcriptional regulator
ES966_RS01680	COG1280	lysine exporter protein (LysE YggA)
ES966_RS01685	COG3403	YqcI/YcgG family
ES966_RS01690	COG1113	amino acid transport
ES966_RS01695	COG3665	Urea carboxylase-associated protein
ES966_RS01710	COG1660	Displays ATPase and GTPase activities
ES966_RS01720	COG2271	Major facilitator Superfamily
ES966_RS01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES966_RS01730	COG3458	cephalosporin-C deacetylase activity
ES966_RS01735	COG3541	Predicted nucleotidyltransferase
ES966_RS01740	COG0506	proline dehydrogenase activity
ES966_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS01755	COG2508	Transcriptional regulator
ES966_RS01765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES966_RS01765	COG1587	Uroporphyrinogen-III synthase
ES966_RS01770	COG2146	nitrite reductase [NAD(P)H] activity
ES966_RS01775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES966_RS01785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES966_RS01790	COG2223	nitrite transmembrane transporter activity
ES966_RS01795	COG0523	cobalamin synthesis protein
ES966_RS01800	COG1063	alcohol dehydrogenase
ES966_RS01805	COG1714	RDD family
ES966_RS01815	COG2723	6-phospho-beta-galactosidase activity
ES966_RS01825	COG3209	COG3209 Rhs family protein
ES966_RS01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES966_RS01835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES966_RS01840	COG1733	regulation of RNA biosynthetic process
ES966_RS01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS01860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES966_RS01875	COG2364	Membrane
ES966_RS01880	COG1126	abc transporter atp-binding protein
ES966_RS01885	COG0765	amino acid transport
ES966_RS01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS01895	COG0583	DNA-binding transcription factor activity
ES966_RS01900	COG0163	prenyltransferase activity
ES966_RS01905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES966_RS01920	COG3104	oligopeptide transport
ES966_RS01925	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_RS01935	COG0697	spore germination
ES966_RS01945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES966_RS01950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS01955	COG0456	acetyltransferase
ES966_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS01965	COG0765	amino acid transport
ES966_RS01970	COG1126	abc transporter atp-binding protein
ES966_RS01975	COG1473	amidohydrolase
ES966_RS01980	COG2079	MmgE PrpD family protein
ES966_RS01985	COG1136	(ABC) transporter
ES966_RS01990	COG0577	efflux transmembrane transporter activity
ES966_RS01995	COG0745	RESPONSE REGULATOR receiver
ES966_RS02000	COG3850	Histidine kinase
ES966_RS02000	COG5002	protein histidine kinase activity
ES966_RS02005	COG0457	Tetratricopeptide repeat
ES966_RS02020	COG0527	aspartate kinase activity
ES966_RS02025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS02030	COG4605	iron ion homeostasis
ES966_RS02035	COG4604	ABC transporter, ATP-binding protein
ES966_RS02040	COG4607	ABC-type enterochelin transport system periplasmic component
ES966_RS02045	COG2814	Major facilitator Superfamily
ES966_RS02050	COG1309	transcriptional regulator
ES966_RS02055	COG0778	Nitroreductase
ES966_RS02060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES966_RS02065	COG0640	Transcriptional regulator
ES966_RS02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS02085	COG4975	Glucose uptake
ES966_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS02095	COG4549	nuclear export factor GLE1
ES966_RS02105	COG1349	DNA-binding transcription factor activity
ES966_RS02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS02130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES966_RS02140	COG0561	phosphatase activity
ES966_RS02150	COG1914	H( )-stimulated, divalent metal cation uptake system
ES966_RS02160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES966_RS02165	COG1984	allophanate hydrolase subunit 2
ES966_RS02170	COG1414	Transcriptional regulator
ES966_RS02185	COG2329	Antibiotic biosynthesis monooxygenase
ES966_RS02195	COG4989	oxidoreductase activity
ES966_RS02200	COG3711	transcriptional antiterminator
ES966_RS02205	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS02215	COG1917	Cupin 2, conserved barrel domain protein
ES966_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_RS02225	COG3871	stress protein (general stress protein 26)
ES966_RS02235	COG2814	Major facilitator Superfamily
ES966_RS02240	COG1522	sequence-specific DNA binding
ES966_RS02245	COG0551	DNA topoisomerase type I activity
ES966_RS02245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES966_RS02250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ES966_RS02260	COG5298	Protein conserved in bacteria
ES966_RS02265	COG1215	transferase activity, transferring glycosyl groups
ES966_RS02275	COG0531	amino acid
ES966_RS02280	COG0494	nUDIX hydrolase
ES966_RS02285	COG0028	Belongs to the TPP enzyme family
ES966_RS02290	COG1388	LysM domain
ES966_RS02290	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS02290	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_RS02310	COG0457	Tetratricopeptide repeat
ES966_RS02340	COG1914	H( )-stimulated, divalent metal cation uptake system
ES966_RS02355	COG4876	unkown
ES966_RS02370	COG2217	Heavy metal translocating P-type atpase
ES966_RS02375	COG3729	General stress protein
ES966_RS02380	COG0662	Cupin 2, conserved barrel domain protein
ES966_RS02385	COG2329	Antibiotic biosynthesis monooxygenase
ES966_RS02390	COG3546	catalase activity
ES966_RS02395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES966_RS02405	COG4565	transcriptional regulatory protein
ES966_RS02410	COG1301	dicarboxylic acid transport
ES966_RS02415	COG0628	permease
ES966_RS02420	COG1131	(ABC) transporter
ES966_RS02425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_RS02435	COG1960	acyl-CoA dehydrogenase activity
ES966_RS02450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_RS02455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES966_RS02470	COG0513	Belongs to the DEAD box helicase family
ES966_RS02475	COG3402	PFAM membrane-flanked domain
ES966_RS02480	COG3428	Bacterial PH domain
ES966_RS02495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES966_RS02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES966_RS02505	COG0864	Transcriptional regulator
ES966_RS02510	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES966_RS02515	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS02520	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS02525	COG2172	sigma factor antagonist activity
ES966_RS02545	COG1191	sigma factor activity
ES966_RS02550	COG2208	phosphoserine phosphatase activity
ES966_RS02555	COG2183	response to ionizing radiation
ES966_RS02605	COG0582	viral genome integration into host DNA
ES966_RS02610	COG2856	Zn peptidase
ES966_RS02615	COG1396	sequence-specific DNA binding
ES966_RS02700	COG0433	COG0433 Predicted ATPase
ES966_RS02735	COG0457	Tetratricopeptide repeat
ES966_RS02740	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_RS02750	COG0477	Major facilitator Superfamily
ES966_RS02770	COG2030	dehydratase
ES966_RS02785	COG1959	2 iron, 2 sulfur cluster binding
ES966_RS02790	COG2910	NAD(P)H-binding
ES966_RS02800	COG1309	transcriptional regulator
ES966_RS02805	COG3239	Fatty acid desaturase
ES966_RS02815	COG1278	Cold shock
ES966_RS02820	COG1329	Transcriptional regulator
ES966_RS02825	COG1794	racemase activity, acting on amino acids and derivatives
ES966_RS02840	COG3621	Patatin-like phospholipase
ES966_RS02850	COG0662	Cupin 2, conserved barrel domain protein
ES966_RS02865	COG0277	FAD linked oxidase domain protein
ES966_RS02890	COG0662	Cupin 2, conserved barrel domain protein
ES966_RS02895	COG2318	DinB family
ES966_RS02900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES966_RS02925	COG1064	alcohol dehydrogenase
ES966_RS02930	COG0789	Transcriptional regulator
ES966_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_RS02955	COG2814	Major facilitator Superfamily
ES966_RS02960	COG1309	transcriptional regulator
ES966_RS02965	COG5577	PFAM Coat F domain
ES966_RS02975	COG1063	alcohol dehydrogenase
ES966_RS02980	COG5577	PFAM Coat F domain
ES966_RS02995	COG4585	Histidine kinase
ES966_RS03000	COG2197	response regulator
ES966_RS03005	COG2409	Drug exporters of the RND superfamily
ES966_RS03010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ES966_RS03015	COG0488	(ABC) transporter
ES966_RS03020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_RS03025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS03035	COG2814	Major facilitator Superfamily
ES966_RS03040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_RS03050	COG0730	response to heat
ES966_RS03055	COG0456	acetyltransferase
ES966_RS03060	COG4978	Transcriptional regulator
ES966_RS03060	COG0789	Transcriptional regulator
ES966_RS03065	COG0697	spore germination
ES966_RS03070	COG1051	belongs to the nudix hydrolase family
ES966_RS03075	COG2226	methyltransferase
ES966_RS03080	COG0473	3-isopropylmalate dehydrogenase activity
ES966_RS03085	COG1802	Transcriptional regulator
ES966_RS03090	COG1819	glycosyl
ES966_RS03105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_RS03110	COG1388	LysM domain
ES966_RS03115	COG2814	Major facilitator Superfamily
ES966_RS03120	COG2188	Transcriptional regulator
ES966_RS03125	COG2186	Transcriptional regulator
ES966_RS03135	COG2076	Multidrug Resistance protein
ES966_RS03140	COG2076	Multidrug Resistance protein
ES966_RS03145	COG1309	transcriptional regulator
ES966_RS03150	COG0531	amino acid
ES966_RS03160	COG3832	glyoxalase III activity
ES966_RS03165	COG0604	alcohol dehydrogenase
ES966_RS03175	COG2814	Major facilitator Superfamily
ES966_RS03215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES966_RS03220	COG0802	atpase or kinase
ES966_RS03225	COG1214	PFAM Peptidase M22, glycoprotease
ES966_RS03230	COG0456	acetyltransferase
ES966_RS03235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES966_RS03240	COG0488	(ABC) transporter
ES966_RS03255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES966_RS03260	COG0805	protein transport
ES966_RS03270	COG1266	CAAX protease self-immunity
ES966_RS03285	COG0156	8-amino-7-oxononanoate synthase activity
ES966_RS03305	COG3403	YqcI/YcgG family
ES966_RS03320	COG2814	Major facilitator Superfamily
ES966_RS03325	COG0457	Tetratricopeptide repeat
ES966_RS03330	COG1063	alcohol dehydrogenase
ES966_RS03335	COG2211	Major facilitator Superfamily
ES966_RS03340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_RS03350	COG1842	Phage shock protein A
ES966_RS03355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES966_RS03360	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES966_RS03365	COG4260	virion core protein, lumpy skin disease virus
ES966_RS03370	COG2755	lipolytic protein G-D-S-L family
ES966_RS03370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES966_RS03380	COG1595	DNA-templated transcription, initiation
ES966_RS03385	COG1063	alcohol dehydrogenase
ES966_RS03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES966_RS03395	COG0823	Involved in the tonB-independent uptake of proteins
ES966_RS03410	COG2132	Multicopper oxidase
ES966_RS03415	COG1113	amino acid transport
ES966_RS03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_RS03425	COG0714	Associated with various cellular activities
ES966_RS03430	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES966_RS03435	COG1305	Transglutaminase-like
ES966_RS03465	COG2211	Major facilitator Superfamily
ES966_RS03480	COG2252	PERMEase
ES966_RS03485	COG3064	Membrane
ES966_RS03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES966_RS03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES966_RS03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES966_RS03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES966_RS03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES966_RS03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES966_RS03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES966_RS03555	COG0138	bifunctional purine biosynthesis protein purh
ES966_RS03560	COG0151	Belongs to the GarS family
ES966_RS03570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES966_RS03580	COG4496	protein, YerC YecD
ES966_RS03585	COG0069	glutamate synthase activity
ES966_RS03600	COG0210	DNA helicase
ES966_RS03610	COG4851	CamS sex pheromone cAM373 precursor
ES966_RS03615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_RS03620	COG1285	pathogenesis
ES966_RS03625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_RS03645	COG1309	transcriptional regulator
ES966_RS03655	COG1597	lipid kinase activity
ES966_RS03660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES966_RS03665	COG2197	response regulator
ES966_RS03675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS03685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS03700	COG1131	(ABC) transporter
ES966_RS03740	COG5444	nuclease activity
ES966_RS03770	COG3546	catalase activity
ES966_RS03775	COG0454	-acetyltransferase
ES966_RS03785	COG2323	membrane
ES966_RS03790	COG2329	Antibiotic biosynthesis monooxygenase
ES966_RS03795	COG0346	lactoylglutathione lyase activity
ES966_RS03805	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS03810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ES966_RS03815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ES966_RS03830	COG5583	Uncharacterized small protein (DUF2292)
ES966_RS03835	COG0196	riboflavin kinase activity
ES966_RS03840	COG0670	Belongs to the BI1 family
ES966_RS03845	COG1846	Transcriptional regulator
ES966_RS03850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES966_RS03875	COG1131	(ABC) transporter
ES966_RS03890	COG1368	sulfuric ester hydrolase activity
ES966_RS03895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES966_RS03900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_RS03905	COG1442	glycosyl transferase family 8
ES966_RS03910	COG1216	Glycosyl transferase, family 2
ES966_RS03915	COG1442	glycosyl transferase family 8
ES966_RS03920	COG2223	nitrite transmembrane transporter activity
ES966_RS03925	COG0531	amino acid
ES966_RS03930	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS03935	COG0840	transmembrane signaling receptor activity
ES966_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS03945	COG0457	Tetratricopeptide repeat
ES966_RS03945	COG0463	Glycosyl transferase, family 2
ES966_RS03950	COG0488	(ABC) transporter
ES966_RS03955	COG0789	Transcriptional regulator
ES966_RS03960	COG2814	Major facilitator Superfamily
ES966_RS03965	COG0488	(ABC) transporter
ES966_RS03970	COG0513	Belongs to the DEAD box helicase family
ES966_RS03980	COG2130	NADP-dependent
ES966_RS03995	COG3866	Pectate lyase
ES966_RS04000	COG0471	metal ion transport
ES966_RS04030	COG0745	RESPONSE REGULATOR receiver
ES966_RS04030	COG2972	Histidine kinase
ES966_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS04055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES966_RS04065	COG2258	MOSC domain
ES966_RS04085	COG0024	Methionine aminopeptidase
ES966_RS04090	COG1263	PTS System
ES966_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_RS04100	COG1368	sulfuric ester hydrolase activity
ES966_RS04110	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_RS04125	COG1263	PTS System
ES966_RS04130	COG0366	Alpha amylase catalytic
ES966_RS04135	COG2188	Transcriptional regulator
ES966_RS04140	COG0778	Nitroreductase
ES966_RS04155	COG0737	Belongs to the 5'-nucleotidase family
ES966_RS04160	COG0693	protein deglycase activity
ES966_RS04165	COG1609	Transcriptional regulator
ES966_RS04180	COG2814	Major facilitator Superfamily
ES966_RS04190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES966_RS04195	COG4980	gas vesicle protein
ES966_RS04200	COG1295	ribonuclease BN
ES966_RS04205	COG0477	Major facilitator Superfamily
ES966_RS04220	COG0668	transmembrane transport
ES966_RS04225	COG0535	radical SAM domain protein
ES966_RS04235	COG0726	polysaccharide deacetylase
ES966_RS04240	COG2084	Dehydrogenase
ES966_RS04250	COG0598	Magnesium transport protein CorA
ES966_RS04255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES966_RS04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES966_RS04270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES966_RS04275	COG4637	Psort location Cytoplasmic, score
ES966_RS04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_RS04295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_RS04300	COG3284	Transcriptional regulator
ES966_RS04310	COG1486	melibiose metabolic process
ES966_RS04315	COG1737	Transcriptional regulator
ES966_RS04325	COG1132	(ABC) transporter
ES966_RS04330	COG1132	(ABC) transporter
ES966_RS04335	COG2259	Doxx family
ES966_RS04340	COG2514	catechol 2,3-dioxygenase activity
ES966_RS04355	COG1695	Transcriptional regulator
ES966_RS04360	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_RS04365	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES966_RS04370	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_RS04370	COG3848	Pyruvate phosphate dikinase
ES966_RS04375	COG2732	(Barnase) inhibitor
ES966_RS04380	COG2318	DinB family
ES966_RS04385	COG2814	Major facilitator Superfamily
ES966_RS04390	COG1846	Transcriptional regulator
ES966_RS04395	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES966_RS04395	COG0392	lysyltransferase activity
ES966_RS04400	COG0384	phenazine biosynthesis protein PhzF
ES966_RS04405	COG0778	Nitroreductase
ES966_RS04420	COG1090	epimerase
ES966_RS04435	COG2814	Major facilitator Superfamily
ES966_RS04445	COG3591	Belongs to the peptidase S1B family
ES966_RS04460	COG3103	Sh3 type 3 domain protein
ES966_RS04465	COG5658	integral membrane protein
ES966_RS04470	COG0596	Alpha beta hydrolase
ES966_RS04475	COG0463	Glycosyl transferase, family 2
ES966_RS04480	COG4485	Bacterial membrane protein, YfhO
ES966_RS04485	COG1988	membrane-bound metal-dependent
ES966_RS04490	COG1194	a g-specific adenine glycosylase
ES966_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS04520	COG1132	(ABC) transporter
ES966_RS04525	COG4129	membrane
ES966_RS04535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES966_RS04540	COG0735	belongs to the Fur family
ES966_RS04680	COG5577	PFAM Coat F domain
ES966_RS04685	COG3340	Belongs to the peptidase S51 family
ES966_RS04695	COG0277	FAD linked oxidase domain protein
ES966_RS04705	COG0747	negative chemotaxis
ES966_RS04710	COG0601	transmembrane transport
ES966_RS04715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_RS04720	COG0444	Belongs to the ABC transporter superfamily
ES966_RS04725	COG4608	Belongs to the ABC transporter superfamily
ES966_RS04730	COG0753	catalase activity
ES966_RS04745	COG1116	anion transmembrane transporter activity
ES966_RS04750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES966_RS04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES966_RS04780	COG1476	TRANSCRIPTIONal
ES966_RS04790	COG3382	B3 4 domain protein
ES966_RS04795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES966_RS04805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES966_RS04810	COG0789	Transcriptional regulator
ES966_RS04815	COG1664	Polymer-forming cytoskeletal
ES966_RS04820	COG1664	Polymer-forming cytoskeletal
ES966_RS04825	COG2766	serine protein kinase
ES966_RS04840	COG1846	Transcriptional regulator
ES966_RS04845	COG1566	PFAM secretion protein HlyD family protein
ES966_RS04850	COG2814	Major facilitator Superfamily
ES966_RS04855	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES966_RS04870	COG1725	Transcriptional regulator
ES966_RS04875	COG1131	(ABC) transporter
ES966_RS04880	COG1131	(ABC) transporter
ES966_RS04885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_RS04895	COG1278	Cold shock
ES966_RS04905	COG1464	Belongs to the NlpA lipoprotein family
ES966_RS04910	COG3706	GGDEF domain
ES966_RS04915	COG1823	symporter activity
ES966_RS04935	COG5577	PFAM Coat F domain
ES966_RS04940	COG1525	nuclease
ES966_RS04940	COG4085	toxin activity
ES966_RS04940	COG0737	Belongs to the 5'-nucleotidase family
ES966_RS04945	COG3764	Sortase (surface protein transpeptidase)
ES966_RS04950	COG0564	pseudouridine synthase activity
ES966_RS04960	COG0517	IMP dehydrogenase activity
ES966_RS04965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES966_RS04970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES966_RS04970	COG3153	acetyltransferase
ES966_RS04980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_RS04985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES966_RS04990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES966_RS05000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES966_RS05010	COG2203	Gaf domain
ES966_RS05010	COG4585	Histidine kinase
ES966_RS05020	COG0431	NADPH-dependent FMN reductase
ES966_RS05035	COG1388	LysM domain
ES966_RS05035	COG0791	NLP P60 protein
ES966_RS05040	COG1959	2 iron, 2 sulfur cluster binding
ES966_RS05050	COG0668	transmembrane transport
ES966_RS05055	COG2719	SpoVR family
ES966_RS05060	COG1785	Belongs to the alkaline phosphatase family
ES966_RS05065	COG1388	LysM domain
ES966_RS05065	COG0791	NLP P60 protein
ES966_RS05070	COG0583	DNA-binding transcription factor activity
ES966_RS05075	COG0372	Belongs to the citrate synthase family
ES966_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS05085	COG0531	amino acid
ES966_RS05090	COG0733	neurotransmitter:sodium symporter activity
ES966_RS05105	COG1595	DNA-templated transcription, initiation
ES966_RS05110	COG0204	Acyl-transferase
ES966_RS05115	COG1253	flavin adenine dinucleotide binding
ES966_RS05120	COG0789	Transcriptional regulator
ES966_RS05125	COG0436	Aminotransferase
ES966_RS05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_RS05135	COG1253	flavin adenine dinucleotide binding
ES966_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES966_RS05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES966_RS05150	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_RS05160	COG0668	transmembrane transport
ES966_RS05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES966_RS05170	COG0726	polysaccharide deacetylase
ES966_RS05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_RS05180	COG3226	Transcriptional regulator
ES966_RS05190	COG0589	response to stress
ES966_RS05195	COG1132	(ABC) transporter
ES966_RS05200	COG1132	(ABC) transporter
ES966_RS05205	COG0702	epimerase
ES966_RS05225	COG0189	ligase activity
ES966_RS05230	COG0189	ligase activity
ES966_RS05245	COG4335	DNA alkylation repair
ES966_RS05250	COG0561	phosphatase activity
ES966_RS05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES966_RS05265	COG0475	glutathione-regulated potassium exporter activity
ES966_RS05270	COG0490	domain, Protein
ES966_RS05280	COG1024	Enoyl-CoA hydratase
ES966_RS05290	COG4152	abc transporter atp-binding protein
ES966_RS05295	COG1668	transmembrane transport
ES966_RS05300	COG0420	3'-5' exonuclease activity
ES966_RS05305	COG4717	serine-type aminopeptidase activity
ES966_RS05320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES966_RS05360	COG4980	gas vesicle protein
ES966_RS05375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES966_RS05380	COG0537	adenosine 5'-monophosphoramidase activity
ES966_RS05385	COG1131	(ABC) transporter
ES966_RS05390	COG4473	ABC transporter
ES966_RS05400	COG1473	amidohydrolase
ES966_RS05405	COG3069	C4-dicarboxylate transmembrane transporter activity
ES966_RS05410	COG2329	Antibiotic biosynthesis monooxygenase
ES966_RS05415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_RS05425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ES966_RS05430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ES966_RS05435	COG1309	transcriptional regulator
ES966_RS05440	COG1511	domain protein
ES966_RS05445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_RS05455	COG1363	Peptidase, m42
ES966_RS05460	COG1301	dicarboxylic acid transport
ES966_RS05470	COG1234	tRNA 3'-trailer cleavage
ES966_RS05475	COG0095	Lipoate-protein ligase
ES966_RS05480	COG0702	epimerase
ES966_RS05485	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS05495	COG0501	Belongs to the peptidase M48B family
ES966_RS05500	COG1404	Belongs to the peptidase S8 family
ES966_RS05515	COG0406	alpha-ribazole phosphatase activity
ES966_RS05520	COG0183	Belongs to the thiolase family
ES966_RS05525	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS05530	COG1268	BioY protein
ES966_RS05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_RS05540	COG0723	plastoquinol--plastocyanin reductase activity
ES966_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS05555	COG4903	ComK protein
ES966_RS05565	COG5646	InterPro IPR014922
ES966_RS05590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_RS05605	COG0398	Pfam SNARE associated Golgi protein
ES966_RS05610	COG0681	Belongs to the peptidase S26 family
ES966_RS05615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES966_RS05620	COG1846	Transcriptional regulator
ES966_RS05630	COG2814	Major facilitator Superfamily
ES966_RS05640	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES966_RS05645	COG2323	membrane
ES966_RS05660	COG0420	3'-5' exonuclease activity
ES966_RS05665	COG0419	ATPase involved in DNA repair
ES966_RS05670	COG1403	HNH endonuclease
ES966_RS05715	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES966_RS05730	COG0367	asparagine synthase
ES966_RS05740	COG0534	Mate efflux family protein
ES966_RS05745	COG1917	Cupin 2, conserved barrel domain protein
ES966_RS05745	COG2207	Transcriptional regulator
ES966_RS05750	COG1609	Transcriptional regulator
ES966_RS05755	COG0673	inositol 2-dehydrogenase activity
ES966_RS05760	COG2318	DinB family
ES966_RS05765	COG1279	arginine transmembrane transporter activity
ES966_RS05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_RS05775	COG1357	PFAM Pentapeptide repeats (8 copies)
ES966_RS05780	COG2153	protein acetylation
ES966_RS05785	COG0646	methionine synthase
ES966_RS05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES966_RS05795	COG2996	Protein conserved in bacteria
ES966_RS05800	COG1744	ABC transporter substrate-binding protein PnrA-like
ES966_RS05805	COG0840	transmembrane signaling receptor activity
ES966_RS05810	COG2124	cytochrome p450
ES966_RS05820	COG1307	EDD domain protein, DegV family
ES966_RS05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS05840	COG0561	phosphatase activity
ES966_RS05845	COG1073	alpha beta
ES966_RS05850	COG2151	metal-sulfur cluster biosynthetic enzyme
ES966_RS05860	COG0277	FAD linked oxidase domain protein
ES966_RS05865	COG2271	Major facilitator Superfamily
ES966_RS05875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ES966_RS05885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES966_RS05895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES966_RS05900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES966_RS05935	COG1744	ABC transporter substrate-binding protein PnrA-like
ES966_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_RS05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_RS05960	COG5504	Zn-dependent protease
ES966_RS05965	COG0444	Belongs to the ABC transporter superfamily
ES966_RS05970	COG4608	Belongs to the ABC transporter superfamily
ES966_RS05980	COG0601	transmembrane transport
ES966_RS05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_RS05995	COG0180	Tryptophanyl-tRNA synthetase
ES966_RS06000	COG4166	transmembrane transport
ES966_RS06005	COG0601	transmembrane transport
ES966_RS06010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_RS06015	COG0444	Belongs to the ABC transporter superfamily
ES966_RS06020	COG4608	Belongs to the ABC transporter superfamily
ES966_RS06030	COG0456	acetyltransferase
ES966_RS06035	COG1393	Belongs to the ArsC family
ES966_RS06040	COG0861	Integral membrane protein TerC family
ES966_RS06045	COG4862	establishment of competence for transformation
ES966_RS06050	COG4469	Competence protein
ES966_RS06055	COG1164	Oligoendopeptidase f
ES966_RS06060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES966_RS06065	COG2346	COG2346, Truncated hemoglobins
ES966_RS06070	COG0741	lytic transglycosylase activity
ES966_RS06075	COG4116	CYTH
ES966_RS06085	COG2357	RelA SpoT domain protein
ES966_RS06095	COG0564	pseudouridine synthase activity
ES966_RS06105	COG0475	glutathione-regulated potassium exporter activity
ES966_RS06105	COG0569	domain protein
ES966_RS06110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES966_RS06115	COG0352	thiamine-phosphate diphosphorylase activity
ES966_RS06120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_RS06125	COG2104	thiamine diphosphate biosynthetic process
ES966_RS06135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES966_RS06140	COG0351	phosphomethylpyrimidine kinase
ES966_RS06145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES966_RS06200	COG0210	DNA helicase
ES966_RS06220	COG1131	(ABC) transporter
ES966_RS06230	COG2153	protein acetylation
ES966_RS06240	COG2382	esterase
ES966_RS06245	COG0626	cystathionine gamma-synthase activity
ES966_RS06250	COG0626	cystathionine gamma-synthase activity
ES966_RS06330	COG3655	Transcriptional regulator
ES966_RS06370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS06370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS06410	COG1780	Probably involved in ribonucleotide reductase function
ES966_RS06415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_RS06420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_RS06425	COG0756	dUTP diphosphatase activity
ES966_RS06435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ES966_RS06440	COG3584	3D domain protein
ES966_RS06480	COG1793	dna ligase
ES966_RS06535	COG0582	viral genome integration into host DNA
ES966_RS06620	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_RS06630	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_RS06650	COG4824	toxin secretion phage lysis holin
ES966_RS06655	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS06655	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_RS06690	COG0582	viral genome integration into host DNA
ES966_RS06790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES966_RS06845	COG3328	transposase activity
ES966_RS06920	COG5444	nuclease activity
ES966_RS06950	COG2367	Beta-lactamase
ES966_RS06955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES966_RS06960	COG0477	Major facilitator Superfamily
ES966_RS06965	COG1846	Transcriptional regulator
ES966_RS06980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES966_RS06985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES966_RS06990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS06990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS06995	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_RS07025	COG1285	pathogenesis
ES966_RS07040	COG2205	protein histidine kinase activity
ES966_RS07050	COG3383	formate dehydrogenase (NAD+) activity
ES966_RS07055	COG2427	Protein of unknown function (DUF1641)
ES966_RS07060	COG2124	cytochrome p450
ES966_RS07075	COG1587	Uroporphyrinogen-III synthase
ES966_RS07080	COG0390	transport system, permease component
ES966_RS07085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_RS07090	COG0697	spore germination
ES966_RS07095	COG4297	protein containing double-stranded beta helix domain
ES966_RS07105	COG1252	NADH dehydrogenase
ES966_RS07120	COG1609	Transcriptional regulator
ES966_RS07125	COG0246	Mannitol dehydrogenase
ES966_RS07130	COG2721	sulfolactate sulfo-lyase activity
ES966_RS07135	COG0745	RESPONSE REGULATOR receiver
ES966_RS07140	COG2770	Histidine kinase
ES966_RS07140	COG2205	protein histidine kinase activity
ES966_RS07160	COG4585	Histidine kinase
ES966_RS07165	COG2197	response regulator
ES966_RS07195	COG0730	response to heat
ES966_RS07200	COG2318	DinB family
ES966_RS07205	COG0457	Tetratricopeptide repeat
ES966_RS07210	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS07210	COG1388	LysM domain
ES966_RS07210	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_RS07220	COG4195	phage-related replication protein
ES966_RS07225	COG2856	Zn peptidase
ES966_RS07230	COG1396	sequence-specific DNA binding
ES966_RS07240	COG1522	sequence-specific DNA binding
ES966_RS07245	COG1484	DNA-dependent DNA replication
ES966_RS07260	COG1595	DNA-templated transcription, initiation
ES966_RS07265	COG4193	domain, Protein
ES966_RS07300	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_RS07300	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS07315	COG0306	phosphate transporter
ES966_RS07320	COG1392	Phosphate transport regulator
ES966_RS07325	COG0531	amino acid
ES966_RS07330	COG0346	lactoylglutathione lyase activity
ES966_RS07335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES966_RS07340	COG0463	Glycosyl transferase, family 2
ES966_RS07345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_RS07350	COG0477	Major facilitator Superfamily
ES966_RS07355	COG2362	D-Aminopeptidase
ES966_RS07360	COG0601	transmembrane transport
ES966_RS07365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_RS07370	COG0444	Belongs to the ABC transporter superfamily
ES966_RS07375	COG4166	transmembrane transport
ES966_RS07380	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES966_RS07385	COG4948	Mandelate Racemase Muconate Lactonizing
ES966_RS07390	COG0791	NLP P60 protein
ES966_RS07395	COG4608	Belongs to the ABC transporter superfamily
ES966_RS07400	COG2706	6-phosphogluconolactonase activity
ES966_RS07405	COG1834	amidinotransferase
ES966_RS07410	COG1607	acyl-coa hydrolase
ES966_RS07415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_RS07420	COG2076	Multidrug Resistance protein
ES966_RS07425	COG2076	Multidrug Resistance protein
ES966_RS07430	COG0788	formyltetrahydrofolate deformylase activity
ES966_RS07435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES966_RS07445	COG1764	response to oxidative stress
ES966_RS07450	COG1846	Transcriptional regulator
ES966_RS07455	COG1764	response to oxidative stress
ES966_RS07470	COG0457	Tetratricopeptide repeat
ES966_RS07470	COG0463	Glycosyl transferase, family 2
ES966_RS07480	COG2814	Major facilitator Superfamily
ES966_RS07485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_RS07495	COG1404	Belongs to the peptidase S8 family
ES966_RS07500	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS07505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES966_RS07510	COG1122	ATPase activity
ES966_RS07515	COG4721	ABC-type cobalt transport system, permease component
ES966_RS07520	COG3858	chitin binding
ES966_RS07520	COG1388	LysM domain
ES966_RS07540	COG2239	Acts as a magnesium transporter
ES966_RS07545	COG0789	Transcriptional regulator
ES966_RS07560	COG1846	Transcriptional regulator
ES966_RS07565	COG0726	polysaccharide deacetylase
ES966_RS07570	COG3285	dna ligase
ES966_RS07570	COG1793	dna ligase
ES966_RS07575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES966_RS07580	COG0586	Pfam SNARE associated Golgi protein
ES966_RS07585	COG0861	Integral membrane protein TerC family
ES966_RS07590	COG1191	sigma factor activity
ES966_RS07615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES966_RS07620	COG2323	membrane
ES966_RS07635	COG5002	protein histidine kinase activity
ES966_RS07640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES966_RS07655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES966_RS07660	COG0436	Aminotransferase
ES966_RS07690	COG3852	Histidine kinase
ES966_RS07695	COG1846	Transcriptional regulator
ES966_RS07700	COG1360	Flagellar Motor Protein
ES966_RS07705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES966_RS07710	COG0542	response to heat
ES966_RS07720	COG3949	Membrane
ES966_RS07735	COG0720	synthase
ES966_RS07740	COG0602	queuosine metabolic process
ES966_RS07745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES966_RS07750	COG1733	regulation of RNA biosynthetic process
ES966_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS07775	COG4873	Protein conserved in bacteria
ES966_RS07785	COG3773	Cell wall hydrolase
ES966_RS07790	COG2244	polysaccharide biosynthetic process
ES966_RS07795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS07800	COG2217	Heavy metal translocating P-type atpase
ES966_RS07805	COG0006	proline dipeptidase activity
ES966_RS07810	COG1609	Transcriptional regulator
ES966_RS07815	COG3711	transcriptional antiterminator
ES966_RS07820	COG1263	PTS System
ES966_RS07820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_RS07820	COG2190	(PTS) system
ES966_RS07825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES966_RS07840	COG1533	DNA photolyase activity
ES966_RS07845	COG0840	transmembrane signaling receptor activity
ES966_RS07850	COG2084	Dehydrogenase
ES966_RS07855	COG2340	Cysteine-rich secretory protein family
ES966_RS07860	COG0768	penicillin binding
ES966_RS07865	COG4191	Histidine kinase
ES966_RS07870	COG0436	Aminotransferase
ES966_RS07880	COG0835	chemotaxis
ES966_RS07880	COG0784	Response regulator, receiver
ES966_RS07895	COG1376	ErfK ybiS ycfS ynhG family protein
ES966_RS07900	COG1408	metallophosphoesterase
ES966_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS07915	COG2200	EAL domain
ES966_RS07920	COG4703	Protein of unknown function (DUF1797)
ES966_RS07925	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES966_RS07935	COG0517	IMP dehydrogenase activity
ES966_RS07940	COG0583	DNA-binding transcription factor activity
ES966_RS07955	COG0716	FMN binding
ES966_RS07975	COG0668	transmembrane transport
ES966_RS07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS08000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES966_RS08005	COG0303	'Molybdopterin
ES966_RS08010	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES966_RS08015	COG0314	molybdopterin synthase activity
ES966_RS08020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES966_RS08030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES966_RS08035	COG1136	(ABC) transporter
ES966_RS08040	COG0577	efflux transmembrane transporter activity
ES966_RS08045	COG1349	DNA-binding transcription factor activity
ES966_RS08050	COG1105	Belongs to the carbohydrate kinase PfkB family
ES966_RS08055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS08055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_RS08055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_RS08060	COG0681	Belongs to the peptidase S26 family
ES966_RS08070	COG0488	(ABC) transporter
ES966_RS08075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES966_RS08080	COG2309	aminopeptidase activity
ES966_RS08090	COG1077	Cell shape determining protein MreB Mrl
ES966_RS08100	COG2002	toxin-antitoxin pair type II binding
ES966_RS08105	COG3852	Histidine kinase
ES966_RS08110	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES966_RS08110	COG2105	PFAM AIG2 family protein
ES966_RS08115	COG0569	domain protein
ES966_RS08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES966_RS08135	COG0561	phosphatase activity
ES966_RS08140	COG0242	peptide deformylase activity
ES966_RS08150	COG0497	DNA recombination
ES966_RS08170	COG3321	synthase
ES966_RS08170	COG0300	oxidoreductase activity
ES966_RS08170	COG4221	oxidoreductase activity
ES966_RS08170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS08175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS08175	COG4221	oxidoreductase activity
ES966_RS08175	COG3321	synthase
ES966_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS08185	COG0300	oxidoreductase activity
ES966_RS08185	COG3321	synthase
ES966_RS08185	COG4221	oxidoreductase activity
ES966_RS08195	COG3321	synthase
ES966_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS08195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS08195	COG4221	oxidoreductase activity
ES966_RS08200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_RS08205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_RS08210	COG0022	dehydrogenase e1 component
ES966_RS08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_RS08220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_RS08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS08240	COG1982	Orn Lys Arg decarboxylase major
ES966_RS08265	COG0483	inositol monophosphate 1-phosphatase activity
ES966_RS08275	COG3227	Zinc metalloprotease (Elastase)
ES966_RS08290	COG1595	DNA-templated transcription, initiation
ES966_RS08310	COG1217	gtp-binding protein TYPA
ES966_RS08320	COG4896	Protein conserved in bacteria
ES966_RS08330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES966_RS08335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES966_RS08340	COG2066	Belongs to the glutaminase family
ES966_RS08350	COG0772	Belongs to the SEDS family
ES966_RS08355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES966_RS08370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES966_RS08370	COG2010	Cytochrome c
ES966_RS08375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES966_RS08380	COG1845	cytochrome c oxidase, subunit III
ES966_RS08385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES966_RS08390	COG3336	cytochrome c oxidase
ES966_RS08400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES966_RS08405	COG2340	Cysteine-rich secretory protein family
ES966_RS08420	COG3679	Belongs to the UPF0342 family
ES966_RS08435	COG0742	ribosomal rna small subunit methyltransferase
ES966_RS08445	COG3314	Sporulation integral membrane protein YlbJ
ES966_RS08450	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES966_RS08455	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES966_RS08465	COG1399	metal-binding, possibly nucleic acid-binding protein
ES966_RS08485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES966_RS08505	COG4839	cell division protein FtsL
ES966_RS08510	COG0768	penicillin binding
ES966_RS08515	COG0768	penicillin binding
ES966_RS08535	COG0772	Belongs to the SEDS family
ES966_RS08550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES966_RS08560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES966_RS08575	COG1191	sigma factor activity
ES966_RS08580	COG1191	sigma factor activity
ES966_RS08585	COG1119	ATPase activity
ES966_RS08590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_RS08600	COG1496	oxidoreductase activity
ES966_RS08605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES966_RS08615	COG0762	integral membrane protein
ES966_RS08620	COG2302	S4 RNA-binding domain
ES966_RS08625	COG3599	regulation of cell shape
ES966_RS08635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES966_RS08640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_RS08650	COG0564	pseudouridine synthase activity
ES966_RS08660	COG2233	PERMEase
ES966_RS08670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES966_RS08675	COG0505	Belongs to the CarA family
ES966_RS08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES966_RS08695	COG0284	orotidine-5'-phosphate decarboxylase activity
ES966_RS08700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES966_RS08710	COG0306	phosphate transporter
ES966_RS08725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES966_RS08730	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES966_RS08735	COG1648	precorrin-2 dehydrogenase activity
ES966_RS08750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES966_RS08755	COG1561	YicC-like family, N-terminal region
ES966_RS08765	COG0194	GDP metabolic process
ES966_RS08775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES966_RS08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES966_RS08785	COG0242	peptide deformylase activity
ES966_RS08795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES966_RS08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES966_RS08805	COG0631	protein serine/threonine phosphatase activity
ES966_RS08810	COG2815	serine threonine protein kinase
ES966_RS08810	COG0515	serine threonine protein kinase
ES966_RS08820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES966_RS08825	COG1564	THIamine pyrophosphokinase
ES966_RS08840	COG1302	Protein conserved in bacteria
ES966_RS08845	COG1461	Dihydroxyacetone kinase
ES966_RS08850	COG1760	l-serine dehydratase
ES966_RS08855	COG1760	l-serine dehydratase
ES966_RS08860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES966_RS08875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES966_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS08895	COG1196	nuclear chromosome segregation
ES966_RS08915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES966_RS08925	COG1837	Belongs to the UPF0109 family
ES966_RS08950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES966_RS08965	COG2257	FlhB HrpN YscU SpaS Family
ES966_RS08975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES966_RS08980	COG0758	DNA mediated transformation
ES966_RS08985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES966_RS08995	COG4974	Belongs to the 'phage' integrase family
ES966_RS09015	COG1815	bacterial-type flagellum-dependent cell motility
ES966_RS09020	COG1558	bacterial-type flagellum-dependent cell motility
ES966_RS09025	COG1677	Flagellar hook-basal body complex protein FliE
ES966_RS09030	COG1766	The M ring may be actively involved in energy transduction
ES966_RS09035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_RS09040	COG1317	bacterial-type flagellum organization
ES966_RS09045	COG1157	protein secretion by the type III secretion system
ES966_RS09050	COG2882	bacterial-type flagellum organization
ES966_RS09055	COG3334	PFAM MgtE intracellular
ES966_RS09060	COG3144	bacterial-type flagellum assembly
ES966_RS09065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES966_RS09070	COG4786	Flagellar basal body rod
ES966_RS09075	COG1582	Flagellar protein (FlbD)
ES966_RS09080	COG1580	Controls the rotational direction of flagella during chemotaxis
ES966_RS09085	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_RS09090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_RS09090	COG1776	CheC inhibitor of MCP methylation
ES966_RS09095	COG2201	protein-glutamate methylesterase activity
ES966_RS09100	COG3190	flagellar
ES966_RS09105	COG1338	Plays a role in the flagellum-specific transport system
ES966_RS09110	COG1987	bacterial-type flagellum assembly
ES966_RS09115	COG1684	flagellar biosynthetic protein fliR
ES966_RS09120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES966_RS09125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES966_RS09130	COG1419	protein localization to endoplasmic reticulum
ES966_RS09135	COG0455	bacterial-type flagellum organization
ES966_RS09140	COG2201	protein-glutamate methylesterase activity
ES966_RS09145	COG2198	Histidine kinase
ES966_RS09145	COG0643	Histidine kinase
ES966_RS09150	COG0835	chemotaxis
ES966_RS09155	COG1776	CheC inhibitor of MCP methylation
ES966_RS09165	COG1191	sigma factor activity
ES966_RS09195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES966_RS09200	COG4589	Belongs to the CDS family
ES966_RS09210	COG0750	zinc metalloprotease
ES966_RS09230	COG0195	Participates in both transcription termination and antitermination
ES966_RS09235	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES966_RS09240	COG1358	cellular component organization or biogenesis
ES966_RS09250	COG1550	Protein conserved in bacteria
ES966_RS09265	COG0196	riboflavin kinase activity
ES966_RS09280	COG0726	polysaccharide deacetylase
ES966_RS09285	COG0612	Peptidase, M16
ES966_RS09290	COG1873	PFAM PRC-barrel domain
ES966_RS09295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES966_RS09300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES966_RS09305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES966_RS09310	COG0527	aspartate kinase activity
ES966_RS09320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES966_RS09325	COG0740	serine-type endopeptidase activity
ES966_RS09335	COG1674	ftsk spoiiie
ES966_RS09335	COG4980	gas vesicle protein
ES966_RS09340	COG2188	Transcriptional regulator
ES966_RS09345	COG2814	Major facilitator Superfamily
ES966_RS09350	COG1846	Transcriptional regulator
ES966_RS09355	COG1033	growth of symbiont in host cell
ES966_RS09355	COG2409	Drug exporters of the RND superfamily
ES966_RS09360	COG0612	Peptidase, M16
ES966_RS09365	COG0612	Peptidase, M16
ES966_RS09370	COG0300	oxidoreductase activity
ES966_RS09390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES966_RS09415	COG1692	metallophosphoesterase
ES966_RS09420	COG2359	stage V sporulation protein S
ES966_RS09440	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES966_RS09505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS09510	COG3425	synthase
ES966_RS09515	COG1024	Enoyl-CoA hydratase
ES966_RS09525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS09525	COG4221	oxidoreductase activity
ES966_RS09525	COG0300	oxidoreductase activity
ES966_RS09525	COG3321	synthase
ES966_RS09545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS09545	COG3321	synthase
ES966_RS09545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ES966_RS09545	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES966_RS09550	COG2124	cytochrome p450
ES966_RS09555	COG3209	COG3209 Rhs family protein
ES966_RS09560	COG3619	membrane
ES966_RS09570	COG1404	Belongs to the peptidase S8 family
ES966_RS09580	COG4195	phage-related replication protein
ES966_RS09585	COG1764	response to oxidative stress
ES966_RS09595	COG2076	Multidrug Resistance protein
ES966_RS09635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_RS09645	COG4112	unkown
ES966_RS09660	COG0464	growth
ES966_RS09665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES966_RS09670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES966_RS09675	COG0789	Transcriptional regulator
ES966_RS09680	COG0174	glutamine synthetase
ES966_RS09710	COG2211	Major facilitator Superfamily
ES966_RS09715	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_RS09735	COG3848	Pyruvate phosphate dikinase
ES966_RS09735	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_RS09760	COG2378	regulation of single-species biofilm formation
ES966_RS09765	COG2318	DinB family
ES966_RS09770	COG1064	alcohol dehydrogenase
ES966_RS09795	COG0456	acetyltransferase
ES966_RS09800	COG5444	nuclease activity
ES966_RS09865	COG3397	chitin binding
ES966_RS09885	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_RS09890	COG0756	dUTP diphosphatase activity
ES966_RS09895	COG4195	phage-related replication protein
ES966_RS09935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES966_RS09955	COG0785	Cytochrome C biogenesis protein
ES966_RS09960	COG2201	protein-glutamate methylesterase activity
ES966_RS09965	COG4846	Membrane protein involved in cytochrome C biogenesis
ES966_RS09975	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_RS09990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES966_RS09995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS10015	COG0824	Thioesterase
ES966_RS10025	COG4841	protein insertion into membrane
ES966_RS10035	COG1832	CoA-binding protein
ES966_RS10040	COG0187	DNA topoisomerase II activity
ES966_RS10045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES966_RS10055	COG1115	amino acid carrier protein
ES966_RS10065	COG1063	alcohol dehydrogenase
ES966_RS10070	COG0800	Aldolase
ES966_RS10075	COG1312	Catalyzes the dehydration of D-mannonate
ES966_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS10085	COG1609	Transcriptional regulator
ES966_RS10090	COG2271	Major facilitator Superfamily
ES966_RS10135	COG2205	protein histidine kinase activity
ES966_RS10140	COG0745	RESPONSE REGULATOR receiver
ES966_RS10150	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS10180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES966_RS10185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES966_RS10190	COG2610	gluconate transmembrane transporter activity
ES966_RS10195	COG2124	cytochrome p450
ES966_RS10215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_RS10225	COG2246	polysaccharide biosynthetic process
ES966_RS10230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES966_RS10235	COG0586	Pfam SNARE associated Golgi protein
ES966_RS10240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES966_RS10245	COG1024	Enoyl-CoA hydratase
ES966_RS10250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES966_RS10255	COG0511	ligase activity, forming carbon-carbon bonds
ES966_RS10260	COG0439	Biotin carboxylase
ES966_RS10265	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS10270	COG1960	acyl-CoA dehydrogenase activity
ES966_RS10275	COG1649	PFAM Uncharacterised BCR, COG1649
ES966_RS10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS10285	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES966_RS10300	COG2323	membrane
ES966_RS10315	COG2323	membrane
ES966_RS10330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_RS10375	COG2027	D-alanyl-D-alanine carboxypeptidase
ES966_RS10385	COG0534	Mate efflux family protein
ES966_RS10400	COG0582	viral genome integration into host DNA
ES966_RS10405	COG0166	Belongs to the GPI family
ES966_RS10410	COG0405	Gamma-glutamyltransferase
ES966_RS10420	COG0640	Transcriptional regulator
ES966_RS10425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES966_RS10435	COG0604	alcohol dehydrogenase
ES966_RS10445	COG0493	'glutamate synthase
ES966_RS10450	COG0070	glutamate synthase
ES966_RS10450	COG0067	glutamate synthase
ES966_RS10450	COG0069	glutamate synthase activity
ES966_RS10455	COG0583	DNA-binding transcription factor activity
ES966_RS10460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES966_RS10475	COG0300	oxidoreductase activity
ES966_RS10480	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES966_RS10490	COG2814	Major facilitator Superfamily
ES966_RS10495	COG1070	Carbohydrate kinase
ES966_RS10505	COG0243	molybdopterin cofactor binding
ES966_RS10535	COG5444	nuclease activity
ES966_RS10540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_RS10545	COG0662	Cupin 2, conserved barrel domain protein
ES966_RS10545	COG2207	Transcriptional regulator
ES966_RS10550	COG1309	transcriptional regulator
ES966_RS10555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS10565	COG0640	Transcriptional regulator
ES966_RS10570	COG0741	lytic transglycosylase activity
ES966_RS10575	COG2322	membrane
ES966_RS10590	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES966_RS10600	COG3584	3D domain protein
ES966_RS10600	COG1388	LysM domain
ES966_RS10605	COG0514	ATP-dependent DNA helicase (RecQ)
ES966_RS10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES966_RS10620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_RS10635	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_RS10665	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS10670	COG1657	PFAM Prenyltransferase squalene oxidase
ES966_RS10675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES966_RS10680	COG0733	neurotransmitter:sodium symporter activity
ES966_RS10685	COG0385	Bile acid
ES966_RS10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS10695	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_RS10705	COG4548	von Willebrand factor, type A
ES966_RS10710	COG0714	Associated with various cellular activities
ES966_RS10715	COG2032	superoxide dismutase activity
ES966_RS10720	COG1388	LysM domain
ES966_RS10720	COG0791	NLP P60 protein
ES966_RS10725	COG1819	glycosyl
ES966_RS10730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES966_RS10735	COG0534	Mate efflux family protein
ES966_RS10740	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS10745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_RS10750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_RS10760	COG2962	Rard protein
ES966_RS10775	COG1942	4-Oxalocrotonate Tautomerase
ES966_RS10785	COG1733	regulation of RNA biosynthetic process
ES966_RS10790	COG0778	Nitroreductase
ES966_RS10795	COG0400	carboxylic ester hydrolase activity
ES966_RS10800	COG0346	lactoylglutathione lyase activity
ES966_RS10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_RS10820	COG2723	6-phospho-beta-galactosidase activity
ES966_RS10825	COG2188	Transcriptional regulator
ES966_RS10830	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS10830	COG0793	Belongs to the peptidase S41A family
ES966_RS10835	COG2226	methyltransferase
ES966_RS10845	COG1876	peptidase activity
ES966_RS10865	COG0671	phosphoesterase, PA-phosphatase related
ES966_RS10895	COG1509	lysine 2,3-aminomutase activity
ES966_RS10900	COG0456	acetyltransferase
ES966_RS10905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_RS10910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES966_RS10915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES966_RS10920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_RS10935	COG0456	acetyltransferase
ES966_RS10940	COG0463	Glycosyl transferase, family 2
ES966_RS10955	COG4641	Protein conserved in bacteria
ES966_RS10965	COG1086	Polysaccharide biosynthesis protein
ES966_RS10980	COG1846	Transcriptional regulator
ES966_RS10985	COG4698	Protein conserved in bacteria
ES966_RS10990	COG2755	lipolytic protein G-D-S-L family
ES966_RS10995	COG1999	signal sequence binding
ES966_RS11005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES966_RS11010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES966_RS11015	COG1272	protein, Hemolysin III
ES966_RS11020	COG0204	Acyl-transferase
ES966_RS11025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES966_RS11040	COG2136	Putative SAM-dependent methyltransferase
ES966_RS11040	COG2521	methyltransferase
ES966_RS11055	COG1413	lyase activity
ES966_RS11060	COG1418	mRNA catabolic process
ES966_RS11065	COG0386	Belongs to the glutathione peroxidase family
ES966_RS11075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES966_RS11085	COG1278	Cold shock
ES966_RS11105	COG0328	RNA-DNA hybrid ribonuclease activity
ES966_RS11110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES966_RS11115	COG0328	RNA-DNA hybrid ribonuclease activity
ES966_RS11125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS11170	COG1335	isochorismatase
ES966_RS11180	COG2233	PERMEase
ES966_RS11190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES966_RS11195	COG1199	ATP-dependent helicase activity
ES966_RS11210	COG0116	Belongs to the methyltransferase superfamily
ES966_RS11240	COG3359	exonuclease
ES966_RS11245	COG1111	helicase
ES966_RS11245	COG1205	dead DEAH box helicase
ES966_RS11250	COG2190	(PTS) system
ES966_RS11255	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_RS11295	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES966_RS11295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_RS11305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES966_RS11310	COG3935	DnaD domain protein
ES966_RS11320	COG0436	Aminotransferase
ES966_RS11325	COG5353	protein conserved in bacteria
ES966_RS11335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES966_RS11335	COG1199	ATP-dependent helicase activity
ES966_RS11365	COG0438	transferase activity, transferring glycosyl groups
ES966_RS11370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_RS11385	COG1694	Mazg nucleotide pyrophosphohydrolase
ES966_RS11390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS11395	COG2140	Oxalate decarboxylase
ES966_RS11405	COG4347	Protein of unknown function (DUF1405)
ES966_RS11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES966_RS11410	COG2010	Cytochrome c
ES966_RS11415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES966_RS11435	COG0457	Tetratricopeptide repeat
ES966_RS11445	COG0287	Prephenate dehydrogenase
ES966_RS11480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES966_RS11485	COG4401	Chorismate mutase type I
ES966_RS11500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES966_RS11505	COG0105	UTP biosynthetic process
ES966_RS11510	COG0142	geranyltranstransferase activity
ES966_RS11520	COG0142	geranyltranstransferase activity
ES966_RS11535	COG0776	regulation of translation
ES966_RS11580	COG0539	negative regulation of cytoplasmic translation
ES966_RS11590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES966_RS11595	COG2959	enzyme of heme biosynthesis
ES966_RS11600	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS11600	COG3773	Cell wall hydrolase
ES966_RS11610	COG0492	ferredoxin-NADP+ reductase activity
ES966_RS11615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_RS11620	COG4862	establishment of competence for transformation
ES966_RS11625	COG1408	metallophosphoesterase
ES966_RS11635	COG1388	LysM domain
ES966_RS11640	COG1266	CAAX protease self-immunity
ES966_RS11645	COG0514	ATP-dependent DNA helicase (RecQ)
ES966_RS11650	COG4955	Helix-turn-helix domain
ES966_RS11655	COG1141	Ferredoxin
ES966_RS11660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES966_RS11665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES966_RS11675	COG1595	DNA-templated transcription, initiation
ES966_RS11680	COG5002	protein histidine kinase activity
ES966_RS11685	COG0745	RESPONSE REGULATOR receiver
ES966_RS11690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES966_RS11695	COG1333	cytochrome c biogenesis protein
ES966_RS11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS11705	COG1187	pseudouridine synthase activity
ES966_RS11710	COG0700	Nucleoside recognition
ES966_RS11715	COG2715	membrane protein required for spore maturation
ES966_RS11720	COG1686	Belongs to the peptidase S11 family
ES966_RS11745	COG1547	Domain of unknown function (DUF309)
ES966_RS11755	COG0456	acetyltransferase
ES966_RS11770	COG0307	riboflavin synthase, alpha
ES966_RS11775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES966_RS11775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES966_RS11785	COG0681	Belongs to the peptidase S26 family
ES966_RS11795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES966_RS11800	COG4086	secreted protein
ES966_RS11805	COG0019	diaminopimelate decarboxylase activity
ES966_RS11810	COG0697	spore germination
ES966_RS11825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_RS11845	COG1191	sigma factor activity
ES966_RS11855	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS11860	COG1686	Belongs to the peptidase S11 family
ES966_RS11865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES966_RS11870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES966_RS11875	COG4974	Belongs to the 'phage' integrase family
ES966_RS11885	COG0735	belongs to the Fur family
ES966_RS11890	COG1300	Membrane
ES966_RS11905	COG0281	malic enzyme
ES966_RS11910	COG1757	Na H antiporter
ES966_RS11915	COG1027	Aspartate ammonia-lyase
ES966_RS11925	COG1396	sequence-specific DNA binding
ES966_RS11930	COG1379	DNA repair
ES966_RS11935	COG0494	nUDIX hydrolase
ES966_RS11945	COG0667	Aldo Keto reductase
ES966_RS11955	COG1073	alpha beta
ES966_RS11965	COG4918	Iron-sulphur cluster biosynthesis
ES966_RS11970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES966_RS11970	COG0456	acetyltransferase
ES966_RS11975	COG2329	Antibiotic biosynthesis monooxygenase
ES966_RS11980	COG0456	acetyltransferase
ES966_RS11985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES966_RS12000	COG0628	permease
ES966_RS12010	COG0346	lactoylglutathione lyase activity
ES966_RS12020	COG3048	D-serine ammonia-lyase activity
ES966_RS12025	COG0300	oxidoreductase activity
ES966_RS12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS12035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES966_RS12045	COG3425	synthase
ES966_RS12050	COG2124	cytochrome p450
ES966_RS12065	COG3321	synthase
ES966_RS12065	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS12065	COG0300	oxidoreductase activity
ES966_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS12070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS12070	COG0300	oxidoreductase activity
ES966_RS12070	COG3321	synthase
ES966_RS12070	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS12075	COG3321	synthase
ES966_RS12075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_RS12075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS12075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS12085	COG3321	synthase
ES966_RS12085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS12085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_RS12085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS12095	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS12110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES966_RS12110	COG2070	2-Nitropropane dioxygenase
ES966_RS12115	COG0250	Participates in transcription elongation, termination and antitermination
ES966_RS12140	COG0596	Alpha beta hydrolase
ES966_RS12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES966_RS12160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES966_RS12175	COG0706	membrane insertase activity
ES966_RS12180	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES966_RS12185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES966_RS12190	COG0346	lactoylglutathione lyase activity
ES966_RS12195	COG1376	ErfK ybiS ycfS ynhG family protein
ES966_RS12200	COG4129	membrane
ES966_RS12205	COG1126	abc transporter atp-binding protein
ES966_RS12210	COG0765	amino acid transport
ES966_RS12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS12225	COG1597	lipid kinase activity
ES966_RS12230	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_RS12235	COG0022	dehydrogenase e1 component
ES966_RS12240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_RS12245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_RS12250	COG3426	butyrate kinase activity
ES966_RS12255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_RS12260	COG0280	phosphate acetyltransferase
ES966_RS12265	COG3290	protein histidine kinase activity
ES966_RS12265	COG3829	transcription factor binding
ES966_RS12275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES966_RS12280	COG2079	MmgE PrpD family protein
ES966_RS12290	COG1960	acyl-CoA dehydrogenase activity
ES966_RS12295	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES966_RS12300	COG0183	Belongs to the thiolase family
ES966_RS12305	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_RS12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_RS12330	COG1902	pentaerythritol trinitrate reductase activity
ES966_RS12345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES966_RS12350	COG0745	RESPONSE REGULATOR receiver
ES966_RS12355	COG0750	zinc metalloprotease
ES966_RS12360	COG0497	DNA recombination
ES966_RS12370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES966_RS12380	COG0142	geranyltranstransferase activity
ES966_RS12390	COG1570	exodeoxyribonuclease VII activity
ES966_RS12405	COG1302	Protein conserved in bacteria
ES966_RS12410	COG0439	Biotin carboxylase
ES966_RS12415	COG0511	ligase activity, forming carbon-carbon bonds
ES966_RS12455	COG3854	ATPases associated with a variety of cellular activities
ES966_RS12470	COG0006	proline dipeptidase activity
ES966_RS12480	COG3872	metal-dependent enzyme
ES966_RS12490	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES966_RS12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES966_RS12525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES966_RS12540	COG1396	sequence-specific DNA binding
ES966_RS12550	COG0681	Belongs to the peptidase S26 family
ES966_RS12575	COG4940	Competence protein ComGF
ES966_RS12585	COG4970	Tfp pilus assembly protein FimT
ES966_RS12590	COG4537	Required for transformation and DNA binding
ES966_RS12595	COG1459	type II secretion system
ES966_RS12600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES966_RS12610	COG1253	flavin adenine dinucleotide binding
ES966_RS12615	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS12625	COG1393	Belongs to the ArsC family
ES966_RS12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS12645	COG0011	TIGRFAM Protein of
ES966_RS12655	COG2866	Carboxypeptidase
ES966_RS12660	COG1940	carbohydrate kinase activity
ES966_RS12665	COG4483	Protein conserved in bacteria
ES966_RS12670	COG1757	Na H antiporter
ES966_RS12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES966_RS12695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES966_RS12700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_RS12705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_RS12710	COG0581	inorganic phosphate transmembrane transporter activity
ES966_RS12715	COG0573	inorganic phosphate transmembrane transporter activity
ES966_RS12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES966_RS12725	COG0768	penicillin binding
ES966_RS12730	COG0477	Major facilitator Superfamily
ES966_RS12735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES966_RS12740	COG2839	Protein conserved in bacteria
ES966_RS12745	COG5521	maltodextrose utilization protein MalA
ES966_RS12750	COG1388	LysM domain
ES966_RS12760	COG4709	membrane
ES966_RS12765	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES966_RS12770	COG0735	belongs to the Fur family
ES966_RS12775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS12790	COG0513	Belongs to the DEAD box helicase family
ES966_RS12805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES966_RS12810	COG2384	SAM-dependent methyltransferase
ES966_RS12815	COG2010	Cytochrome c
ES966_RS12820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES966_RS12825	COG0358	DNA primase activity
ES966_RS12840	COG0517	IMP dehydrogenase activity
ES966_RS12845	COG0751	glycine-tRNA ligase activity
ES966_RS12865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES966_RS12870	COG0295	cytidine deaminase activity
ES966_RS12875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES966_RS12885	COG1480	7TM receptor with intracellular HD hydrolase
ES966_RS12890	COG1702	phosphate starvation-inducible protein PhoH
ES966_RS12895	COG0561	phosphatase activity
ES966_RS12910	COG4864	UPF0365 protein
ES966_RS12915	COG1030	water channel activity
ES966_RS12920	COG1610	YqeY-like protein
ES966_RS12930	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES966_RS12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES966_RS12940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES966_RS12970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES966_RS12985	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_RS13000	COG1466	dna polymerase III delta subunit
ES966_RS13015	COG2333	competence protein COMEC
ES966_RS13015	COG0658	competence protein
ES966_RS13020	COG2131	deaminase
ES966_RS13025	COG1555	photosystem II stabilization
ES966_RS13025	COG1596	polysaccharide export
ES966_RS13030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES966_RS13035	COG2226	methyltransferase
ES966_RS13040	COG0799	negative regulation of ribosome biogenesis
ES966_RS13045	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES966_RS13055	COG1534	Rna-binding protein
ES966_RS13060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES966_RS13065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES966_RS13070	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES966_RS13080	COG2755	lipolytic protein G-D-S-L family
ES966_RS13090	COG0398	Pfam SNARE associated Golgi protein
ES966_RS13125	COG5444	nuclease activity
ES966_RS13130	COG4282	regulation of fungal-type cell wall biogenesis
ES966_RS13145	COG2207	Transcriptional regulator
ES966_RS13145	COG3708	Transcriptional regulator
ES966_RS13150	COG0583	DNA-binding transcription factor activity
ES966_RS13165	COG0642	Histidine kinase
ES966_RS13165	COG5002	protein histidine kinase activity
ES966_RS13170	COG0745	RESPONSE REGULATOR receiver
ES966_RS13175	COG2311	Membrane
ES966_RS13180	COG0454	-acetyltransferase
ES966_RS13185	COG0563	adenylate kinase activity
ES966_RS13195	COG2814	Major facilitator Superfamily
ES966_RS13205	COG0456	acetyltransferase
ES966_RS13210	COG2318	DinB family
ES966_RS13220	COG0561	phosphatase activity
ES966_RS13225	COG0561	phosphatase activity
ES966_RS13240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_RS13240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_RS13240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS13245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS13245	COG3711	transcriptional antiterminator
ES966_RS13255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES966_RS13260	COG0583	DNA-binding transcription factor activity
ES966_RS13265	COG2814	Major facilitator Superfamily
ES966_RS13270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES966_RS13270	COG2124	cytochrome p450
ES966_RS13275	COG1309	transcriptional regulator
ES966_RS13280	COG2226	methyltransferase
ES966_RS13295	COG2116	formate transmembrane transporter activity
ES966_RS13300	COG5609	conserved protein (DUF2294)
ES966_RS13305	COG3383	formate dehydrogenase (NAD+) activity
ES966_RS13310	COG2427	Protein of unknown function (DUF1641)
ES966_RS13320	COG0626	cystathionine gamma-synthase activity
ES966_RS13325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_RS13350	COG0768	penicillin binding
ES966_RS13365	COG0826	peptidase U32
ES966_RS13370	COG0826	peptidase U32
ES966_RS13375	COG4122	O-methyltransferase activity
ES966_RS13380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES966_RS13405	COG0628	permease
ES966_RS13410	COG1126	abc transporter atp-binding protein
ES966_RS13415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS13420	COG0765	amino acid transport
ES966_RS13425	COG0765	amino acid transport
ES966_RS13440	COG3881	PFAM PRC-barrel domain
ES966_RS13445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES966_RS13450	COG0457	Tetratricopeptide repeat
ES966_RS13460	COG1104	cysteine desulfurase activity
ES966_RS13470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES966_RS13475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES966_RS13495	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_RS13495	COG4991	sh3 domain protein
ES966_RS13495	COG3103	Sh3 type 3 domain protein
ES966_RS13505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES966_RS13515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES966_RS13515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES966_RS13520	COG5416	Lipopolysaccharide assembly protein A domain
ES966_RS13525	COG0490	domain, Protein
ES966_RS13530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES966_RS13530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES966_RS13540	COG2244	polysaccharide biosynthetic process
ES966_RS13545	COG2323	membrane
ES966_RS13555	COG1862	Preprotein translocase
ES966_RS13600	COG1388	LysM domain
ES966_RS13610	COG0157	Belongs to the NadC ModD family
ES966_RS13615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES966_RS13620	COG1104	cysteine desulfurase activity
ES966_RS13625	COG1827	regulation of RNA biosynthetic process
ES966_RS13630	COG0077	Prephenate dehydratase
ES966_RS13645	COG3290	protein histidine kinase activity
ES966_RS13650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES966_RS13655	COG2868	ribosomal protein
ES966_RS13665	COG1994	Peptidase M50
ES966_RS13670	COG0739	heme binding
ES966_RS13675	COG2894	cell division
ES966_RS13685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES966_RS13695	COG1077	Cell shape determining protein MreB Mrl
ES966_RS13715	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_RS13715	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS13720	COG4824	toxin secretion phage lysis holin
ES966_RS13740	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_RS13745	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_RS13755	COG5412	phage tail tape measure protein
ES966_RS13755	COG3953	SLT domain
ES966_RS13855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS13855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS13895	COG1396	sequence-specific DNA binding
ES966_RS13925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES966_RS13930	COG0285	dihydrofolate synthase activity
ES966_RS13935	COG0525	valine-tRNA ligase activity
ES966_RS13945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_RS13950	COG1388	LysM domain
ES966_RS13960	COG0113	porphobilinogen synthase activity
ES966_RS13965	COG1587	Uroporphyrinogen-III synthase
ES966_RS13975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES966_RS13995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES966_RS14000	COG1067	ATP-dependent peptidase activity
ES966_RS14000	COG0470	DNA polymerase III
ES966_RS14015	COG0457	Tetratricopeptide repeat
ES966_RS14015	COG1477	protein flavinylation
ES966_RS14030	COG0473	3-isopropylmalate dehydrogenase activity
ES966_RS14045	COG0440	acetolactate synthase activity
ES966_RS14050	COG0028	Belongs to the TPP enzyme family
ES966_RS14080	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ES966_RS14105	COG0622	Phosphoesterase
ES966_RS14110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES966_RS14120	COG5401	PFAM Sporulation and spore germination
ES966_RS14135	COG2197	response regulator
ES966_RS14140	COG0824	Thioesterase
ES966_RS14145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES966_RS14150	COG1053	succinate dehydrogenase
ES966_RS14155	COG2009	succinate dehydrogenase
ES966_RS14160	COG1719	4-vinyl reductase, 4VR
ES966_RS14165	COG0527	aspartate kinase activity
ES966_RS14180	COG3118	belongs to the thioredoxin family
ES966_RS14185	COG3534	alpha-L-arabinofuranosidase
ES966_RS14190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES966_RS14195	COG2086	electron transfer activity
ES966_RS14200	COG1024	Enoyl-CoA hydratase
ES966_RS14205	COG1309	transcriptional regulator
ES966_RS14210	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_RS14220	COG3766	membrane
ES966_RS14230	COG1796	DNA polymerase
ES966_RS14230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES966_RS14235	COG1286	toxin biosynthetic process
ES966_RS14250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_RS14250	COG0072	phenylalanine-tRNA ligase activity
ES966_RS14255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES966_RS14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES966_RS14270	COG3835	regulator
ES966_RS14275	COG0277	FAD linked oxidase domain protein
ES966_RS14280	COG0247	lactate metabolic process
ES966_RS14290	COG3534	alpha-L-arabinofuranosidase
ES966_RS14295	COG0395	ABC-type sugar transport system, permease component
ES966_RS14300	COG1175	transmembrane transport
ES966_RS14315	COG0647	UMP catabolic process
ES966_RS14320	COG0235	Class ii aldolase
ES966_RS14325	COG1069	ribulokinase activity
ES966_RS14330	COG2160	L-arabinose isomerase activity
ES966_RS14335	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_RS14340	COG1363	Peptidase, m42
ES966_RS14350	COG3326	Membrane
ES966_RS14365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES966_RS14370	COG1346	cytolysis
ES966_RS14375	COG1380	Effector of murein hydrolase LrgA
ES966_RS14380	COG3279	Response regulator of the LytR AlgR family
ES966_RS14385	COG3275	phosphorelay sensor kinase activity
ES966_RS14390	COG1011	Hydrolase
ES966_RS14405	COG0398	Pfam SNARE associated Golgi protein
ES966_RS14410	COG1484	DNA-dependent DNA replication
ES966_RS14415	COG3611	Membrane attachment protein
ES966_RS14430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES966_RS14435	COG1733	regulation of RNA biosynthetic process
ES966_RS14440	COG2814	Major facilitator Superfamily
ES966_RS14445	COG0656	L-ascorbic acid biosynthetic process
ES966_RS14460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES966_RS14465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS14465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_RS14470	COG5002	protein histidine kinase activity
ES966_RS14475	COG0745	RESPONSE REGULATOR receiver
ES966_RS14485	COG0538	isocitrate dehydrogenase activity
ES966_RS14490	COG0372	Belongs to the citrate synthase family
ES966_RS14495	COG0457	Tetratricopeptide repeat
ES966_RS14525	COG0628	permease
ES966_RS14530	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES966_RS14535	COG0469	pyruvate kinase activity
ES966_RS14555	COG0281	malic enzyme
ES966_RS14580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES966_RS14590	COG4109	DRTGG domain
ES966_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS14615	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES966_RS14625	COG0827	DNA restriction-modification system
ES966_RS14630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES966_RS14635	COG3874	Sporulation protein YtfJ
ES966_RS14645	COG1714	RDD family
ES966_RS14650	COG0616	signal peptide processing
ES966_RS14655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES966_RS14660	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES966_RS14665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES966_RS14680	COG1104	cysteine desulfurase activity
ES966_RS14685	COG1114	Component of the transport system for branched-chain amino acids
ES966_RS14695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES966_RS14700	COG1309	transcriptional regulator
ES966_RS14725	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS14730	COG4282	regulation of fungal-type cell wall biogenesis
ES966_RS14775	COG1017	nitric oxide dioxygenase activity
ES966_RS14775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES966_RS14790	COG0693	protein deglycase activity
ES966_RS14805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_RS14810	COG1378	Sugar-specific transcriptional regulator TrmB
ES966_RS14835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES966_RS14840	COG0454	-acetyltransferase
ES966_RS14845	COG0517	IMP dehydrogenase activity
ES966_RS14850	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES966_RS14855	COG1360	Flagellar Motor Protein
ES966_RS14860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES966_RS14865	COG1609	Transcriptional regulator
ES966_RS14870	COG1605	Chorismate mutase
ES966_RS14870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES966_RS14875	COG3118	belongs to the thioredoxin family
ES966_RS14880	COG4980	gas vesicle protein
ES966_RS14885	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES966_RS14895	COG1674	ftsk spoiiie
ES966_RS14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_RS14910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS14930	COG1363	Peptidase, m42
ES966_RS14935	COG5584	Small secreted protein
ES966_RS14940	COG0281	malic enzyme
ES966_RS14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_RS14960	COG0510	thiamine kinase activity
ES966_RS14965	COG1597	lipid kinase activity
ES966_RS14975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES966_RS14980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_RS14985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_RS14990	COG2252	PERMEase
ES966_RS14995	COG4473	ABC transporter
ES966_RS15000	COG1131	(ABC) transporter
ES966_RS15005	COG1349	DNA-binding transcription factor activity
ES966_RS15010	COG1187	pseudouridine synthase activity
ES966_RS15015	COG2244	polysaccharide biosynthetic process
ES966_RS15020	COG2081	HI0933 family
ES966_RS15040	COG1609	Transcriptional regulator
ES966_RS15045	COG1653	transport
ES966_RS15050	COG1175	transmembrane transport
ES966_RS15055	COG0395	ABC-type sugar transport system, permease component
ES966_RS15060	COG1486	melibiose metabolic process
ES966_RS15070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES966_RS15085	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_RS15085	COG2202	Pas domain
ES966_RS15090	COG2814	Major facilitator Superfamily
ES966_RS15095	COG5522	Integral membrane protein (intg_mem_TP0381)
ES966_RS15100	COG0577	efflux transmembrane transporter activity
ES966_RS15105	COG1136	(ABC) transporter
ES966_RS15110	COG2205	protein histidine kinase activity
ES966_RS15115	COG0745	RESPONSE REGULATOR receiver
ES966_RS15120	COG0577	efflux transmembrane transporter activity
ES966_RS15125	COG1136	(ABC) transporter
ES966_RS15145	COG1131	(ABC) transporter
ES966_RS15150	COG1725	Transcriptional regulator
ES966_RS15160	COG0640	Transcriptional regulator
ES966_RS15170	COG1242	4 iron, 4 sulfur cluster binding
ES966_RS15175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES966_RS15185	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_RS15195	COG2267	carboxylic ester hydrolase activity
ES966_RS15200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES966_RS15205	COG1113	amino acid transport
ES966_RS15210	COG0367	asparagine synthase
ES966_RS15230	COG1506	peptidase
ES966_RS15235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES966_RS15240	COG1116	anion transmembrane transporter activity
ES966_RS15245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES966_RS15250	COG0494	nUDIX hydrolase
ES966_RS15255	COG4824	toxin secretion phage lysis holin
ES966_RS15260	COG0783	Belongs to the Dps family
ES966_RS15285	COG0288	reversible hydration of carbon dioxide
ES966_RS15295	COG1271	oxidase subunit
ES966_RS15300	COG1294	oxidase, subunit
ES966_RS15310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_RS15315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_RS15315	COG1321	iron dependent repressor
ES966_RS15320	COG1121	(ABC) transporter
ES966_RS15325	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES966_RS15330	COG4948	Mandelate Racemase Muconate Lactonizing
ES966_RS15340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES966_RS15345	COG0596	Alpha beta hydrolase
ES966_RS15355	COG1169	isochorismate synthase
ES966_RS15360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_RS15365	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES966_RS15490	COG3859	Proton-coupled thiamine transporter YuaJ
ES966_RS15495	COG2268	Band 7 protein
ES966_RS15500	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES966_RS15505	COG2318	DinB family
ES966_RS15515	COG1454	alcohol dehydrogenase
ES966_RS15520	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS15525	COG1510	regulation of RNA biosynthetic process
ES966_RS15535	COG0569	domain protein
ES966_RS15540	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_RS15545	COG1017	nitric oxide dioxygenase activity
ES966_RS15545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES966_RS15565	COG0457	Tetratricopeptide repeat
ES966_RS15600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ES966_RS15615	COG0628	permease
ES966_RS15620	COG0673	inositol 2-dehydrogenase activity
ES966_RS15625	COG0693	protein deglycase activity
ES966_RS15640	COG0840	transmembrane signaling receptor activity
ES966_RS15645	COG0840	transmembrane signaling receptor activity
ES966_RS15660	COG2070	2-Nitropropane dioxygenase
ES966_RS15665	COG0432	Pfam Uncharacterised protein family UPF0047
ES966_RS15670	COG0366	Alpha amylase catalytic
ES966_RS15675	COG1253	flavin adenine dinucleotide binding
ES966_RS15680	COG2738	Putative neutral zinc metallopeptidase
ES966_RS15695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES966_RS15725	COG1335	isochorismatase
ES966_RS15740	COG2155	Conserved Protein
ES966_RS15750	COG1098	S1 RNA binding domain
ES966_RS15755	COG0436	Aminotransferase
ES966_RS15760	COG1522	sequence-specific DNA binding
ES966_RS15765	COG2267	carboxylic ester hydrolase activity
ES966_RS15775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES966_RS15780	COG2205	protein histidine kinase activity
ES966_RS15790	COG5018	Exonuclease
ES966_RS15795	COG2814	Major facilitator Superfamily
ES966_RS15800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_RS15805	COG3011	Protein conserved in bacteria
ES966_RS15815	COG3290	protein histidine kinase activity
ES966_RS15820	COG4565	transcriptional regulatory protein
ES966_RS15825	COG1744	ABC transporter substrate-binding protein PnrA-like
ES966_RS15830	COG3845	ABC transporter
ES966_RS15835	COG4603	Belongs to the binding-protein-dependent transport system permease family
ES966_RS15840	COG1079	Belongs to the binding-protein-dependent transport system permease family
ES966_RS15850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES966_RS15850	COG2111	Na H antiporter
ES966_RS15855	COG2111	Na H antiporter
ES966_RS15860	COG1006	Multisubunit Na H antiporter MnhC subunit
ES966_RS15865	COG0651	ATP synthesis coupled electron transport
ES966_RS15870	COG1863	multisubunit Na H antiporter MnhE subunit
ES966_RS15875	COG2212	antiporter activity
ES966_RS15880	COG1320	monovalent cation:proton antiporter activity
ES966_RS15885	COG2050	protein possibly involved in aromatic compounds catabolism
ES966_RS15890	COG2197	response regulator
ES966_RS15895	COG4585	Histidine kinase
ES966_RS15905	COG0142	geranyltranstransferase activity
ES966_RS15925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES966_RS15930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES966_RS15935	COG1335	isochorismatase
ES966_RS15940	COG5506	Protein of unknown function (DUF1694)
ES966_RS15955	COG0628	permease
ES966_RS15965	COG1418	mRNA catabolic process
ES966_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS15990	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES966_RS15995	COG5417	Belongs to the EsaB family
ES966_RS16000	COG4842	Belongs to the WXG100 family
ES966_RS16005	COG2508	Transcriptional regulator
ES966_RS16005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES966_RS16010	COG0686	Belongs to the AlaDH PNT family
ES966_RS16015	COG5634	Uncharacterized conserved protein (DUF2278)
ES966_RS16020	COG3251	PFAM MbtH domain protein
ES966_RS16025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_RS16030	COG1535	isochorismatase
ES966_RS16030	COG3433	isochorismatase activity
ES966_RS16035	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES966_RS16040	COG1169	isochorismate synthase
ES966_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS16050	COG2819	hydrolase of the alpha beta superfamily
ES966_RS16055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES966_RS16060	COG1268	BioY protein
ES966_RS16065	COG2056	Na+-H+ antiporter family
ES966_RS16075	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES966_RS16080	COG3584	3D domain protein
ES966_RS16095	COG1252	NADH dehydrogenase
ES966_RS16145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_RS16150	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ES966_RS16155	COG0316	Belongs to the HesB IscA family
ES966_RS16165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_RS16180	COG4837	Protein of unknown function (DUF1462)
ES966_RS16185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES966_RS16190	COG4946	Tricorn protease homolog
ES966_RS16190	COG1506	peptidase
ES966_RS16190	COG0823	Involved in the tonB-independent uptake of proteins
ES966_RS16200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES966_RS16205	COG0460	homoserine dehydrogenase
ES966_RS16210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_RS16215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES966_RS16220	COG0647	UMP catabolic process
ES966_RS16225	COG2445	Protein of unknown function DUF86
ES966_RS16230	COG4470	Protein conserved in bacteria
ES966_RS16245	COG0739	heme binding
ES966_RS16255	COG0737	Belongs to the 5'-nucleotidase family
ES966_RS16260	COG0730	response to heat
ES966_RS16265	COG1801	Protein of unknown function DUF72
ES966_RS16280	COG2508	Transcriptional regulator
ES966_RS16285	COG0457	Tetratricopeptide repeat
ES966_RS16300	COG2814	Major facilitator Superfamily
ES966_RS16305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES966_RS16310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_RS16315	COG2356	endonuclease I
ES966_RS16320	COG3842	ATPase activity
ES966_RS16325	COG2188	Transcriptional regulator
ES966_RS16330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_RS16335	COG0395	ABC-type sugar transport system, permease component
ES966_RS16340	COG1175	transmembrane transport
ES966_RS16345	COG1653	transport
ES966_RS16350	COG2222	sugar isomerase
ES966_RS16355	COG0789	Transcriptional regulator
ES966_RS16380	COG0322	excinuclease ABC activity
ES966_RS16385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_RS16390	COG2226	methyltransferase
ES966_RS16405	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS16410	COG0719	Fe-S assembly protein
ES966_RS16415	COG0822	iron-sulfur transferase activity
ES966_RS16420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES966_RS16425	COG0719	Fe-S assembly protein
ES966_RS16430	COG0396	ATPase activity
ES966_RS16440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES966_RS16445	COG1464	Belongs to the NlpA lipoprotein family
ES966_RS16450	COG2011	ABC-type metal ion transport system permease component
ES966_RS16455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES966_RS16465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_RS16470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES966_RS16485	COG1393	Belongs to the ArsC family
ES966_RS16490	COG1960	acyl-CoA dehydrogenase activity
ES966_RS16495	COG0183	Belongs to the thiolase family
ES966_RS16500	COG1024	Enoyl-CoA hydratase
ES966_RS16500	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES966_RS16520	COG5577	PFAM Coat F domain
ES966_RS16525	COG1846	Transcriptional regulator
ES966_RS16530	COG0477	Major facilitator Superfamily
ES966_RS16560	COG1120	ATPase activity
ES966_RS16575	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS16580	COG0783	Belongs to the Dps family
ES966_RS16585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_RS16595	COG0745	RESPONSE REGULATOR receiver
ES966_RS16600	COG2205	protein histidine kinase activity
ES966_RS16600	COG2770	Histidine kinase
ES966_RS16610	COG1309	transcriptional regulator
ES966_RS16615	COG0114	fumarate hydratase activity
ES966_RS16625	COG0697	spore germination
ES966_RS16630	COG0814	amino acid
ES966_RS16640	COG2197	response regulator
ES966_RS16650	COG4758	membrane
ES966_RS16655	COG3595	metallopeptidase activity
ES966_RS16660	COG1842	Phage shock protein A
ES966_RS16665	COG4758	membrane
ES966_RS16670	COG2814	Major facilitator Superfamily
ES966_RS16675	COG2096	Adenosyltransferase
ES966_RS16680	COG1120	ATPase activity
ES966_RS16685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS16690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_RS16695	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS16700	COG3386	PFAM SMP-30 Gluconolaconase
ES966_RS16705	COG2205	protein histidine kinase activity
ES966_RS16710	COG0745	RESPONSE REGULATOR receiver
ES966_RS16720	COG1191	sigma factor activity
ES966_RS16730	COG2140	Oxalate decarboxylase
ES966_RS16740	COG1120	ATPase activity
ES966_RS16745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS16750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS16760	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES966_RS16765	COG0531	amino acid
ES966_RS16780	COG1988	membrane-bound metal-dependent
ES966_RS16790	COG1910	domain protein
ES966_RS16795	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES966_RS16800	COG4149	molybdate abc transporter
ES966_RS16805	COG2197	response regulator
ES966_RS16810	COG3850	Histidine kinase
ES966_RS16815	COG1131	(ABC) transporter
ES966_RS16825	COG0842	Transport permease protein
ES966_RS16830	COG0656	L-ascorbic acid biosynthetic process
ES966_RS16855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES966_RS16860	COG3973	AAA domain
ES966_RS16865	COG2860	membrane
ES966_RS16875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES966_RS16880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES966_RS16885	COG2217	Heavy metal translocating P-type atpase
ES966_RS16890	COG2217	Heavy metal translocating P-type atpase
ES966_RS16895	COG2608	mercury ion transmembrane transporter activity
ES966_RS16900	COG1937	Protein conserved in bacteria
ES966_RS16905	COG0673	inositol 2-dehydrogenase activity
ES966_RS16915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS16920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ES966_RS16925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS16930	COG1126	abc transporter atp-binding protein
ES966_RS16935	COG0765	amino acid transport
ES966_RS16940	COG0765	amino acid transport
ES966_RS16945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS16950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_RS16955	COG0454	-acetyltransferase
ES966_RS16960	COG0583	DNA-binding transcription factor activity
ES966_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS16970	COG2732	(Barnase) inhibitor
ES966_RS16980	COG2732	(Barnase) inhibitor
ES966_RS17000	COG4824	toxin secretion phage lysis holin
ES966_RS17020	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_RS17025	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_RS17025	COG1388	LysM domain
ES966_RS17105	COG4626	Terminase
ES966_RS17105	COG1802	Transcriptional regulator
ES966_RS17135	COG0582	viral genome integration into host DNA
ES966_RS17140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ES966_RS17265	COG0582	viral genome integration into host DNA
ES966_RS17280	COG0557	exoribonuclease II activity
ES966_RS17285	COG1647	Serine aminopeptidase, S33
ES966_RS17290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES966_RS17295	COG1476	TRANSCRIPTIONal
ES966_RS17300	COG1396	sequence-specific DNA binding
ES966_RS17305	COG1396	sequence-specific DNA binding
ES966_RS17310	COG1733	regulation of RNA biosynthetic process
ES966_RS17335	COG1131	(ABC) transporter
ES966_RS17340	COG1174	glycine betaine transport
ES966_RS17345	COG1732	Glycine betaine
ES966_RS17350	COG1174	glycine betaine transport
ES966_RS17355	COG1125	glycine betaine transport
ES966_RS17355	COG0517	IMP dehydrogenase activity
ES966_RS17360	COG1510	regulation of RNA biosynthetic process
ES966_RS17365	COG1174	glycine betaine transport
ES966_RS17370	COG1732	Glycine betaine
ES966_RS17375	COG1174	glycine betaine transport
ES966_RS17380	COG0517	IMP dehydrogenase activity
ES966_RS17380	COG1125	glycine betaine transport
ES966_RS17385	COG1510	regulation of RNA biosynthetic process
ES966_RS17390	COG2095	MarC family integral membrane protein
ES966_RS17395	COG3064	Membrane
ES966_RS17405	COG0456	acetyltransferase
ES966_RS17425	COG0126	phosphoglycerate kinase activity
ES966_RS17435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES966_RS17440	COG2390	Transcriptional regulator
ES966_RS17450	COG1609	Transcriptional regulator
ES966_RS17455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS17465	COG0697	spore germination
ES966_RS17475	COG1113	amino acid transport
ES966_RS17480	COG1737	Transcriptional regulator
ES966_RS17485	COG1070	Carbohydrate kinase
ES966_RS17510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_RS17515	COG2186	Transcriptional regulator
ES966_RS17520	COG1620	l-lactate permease
ES966_RS17525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES966_RS17535	COG5039	Polysaccharide pyruvyl transferase
ES966_RS17540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES966_RS17545	COG0110	maltose O-acetyltransferase activity
ES966_RS17550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES966_RS17555	COG2244	polysaccharide biosynthetic process
ES966_RS17560	COG1216	Glycosyl transferase, family 2
ES966_RS17565	COG5039	Polysaccharide pyruvyl transferase
ES966_RS17570	COG1216	Glycosyl transferase, family 2
ES966_RS17580	COG0438	transferase activity, transferring glycosyl groups
ES966_RS17585	COG1215	transferase activity, transferring glycosyl groups
ES966_RS17590	COG0438	transferase activity, transferring glycosyl groups
ES966_RS17595	COG1086	Polysaccharide biosynthesis protein
ES966_RS17600	COG0489	protein tyrosine kinase activity
ES966_RS17605	COG3944	biosynthesis protein
ES966_RS17610	COG1396	sequence-specific DNA binding
ES966_RS17615	COG2272	Belongs to the type-B carboxylesterase lipase family
ES966_RS17625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES966_RS17630	COG2364	Membrane
ES966_RS17635	COG0456	acetyltransferase
ES966_RS17640	COG3479	Phenolic acid decarboxylase
ES966_RS17685	COG1609	Transcriptional regulator
ES966_RS17695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES966_RS17700	COG0366	Alpha amylase catalytic
ES966_RS17705	COG1554	hydrolase, family 65, central catalytic
ES966_RS17710	COG5521	maltodextrose utilization protein MalA
ES966_RS17715	COG3833	ABC-type maltose transport systems, permease component
ES966_RS17720	COG1175	transmembrane transport
ES966_RS17725	COG2182	Extracellular solute-binding protein
ES966_RS17730	COG0366	Alpha amylase catalytic
ES966_RS17735	COG1609	Transcriptional regulator
ES966_RS17745	COG1694	Mazg nucleotide pyrophosphohydrolase
ES966_RS17750	COG0659	secondary active sulfate transmembrane transporter activity
ES966_RS17755	COG0288	reversible hydration of carbon dioxide
ES966_RS17765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES966_RS17770	COG4290	ribonuclease
ES966_RS17775	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES966_RS17780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS17790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES966_RS17800	COG1051	belongs to the nudix hydrolase family
ES966_RS17805	COG0492	ferredoxin-NADP+ reductase activity
ES966_RS17810	COG3883	PFAM NLP P60 protein
ES966_RS17810	COG0791	NLP P60 protein
ES966_RS17815	COG0457	Tetratricopeptide repeat
ES966_RS17820	COG5002	protein histidine kinase activity
ES966_RS17825	COG0745	RESPONSE REGULATOR receiver
ES966_RS17830	COG1132	(ABC) transporter
ES966_RS17835	COG0140	phosphoribosyl-ATP diphosphatase activity
ES966_RS17835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES966_RS17860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES966_RS17875	COG4990	cell redox homeostasis
ES966_RS17880	COG0110	maltose O-acetyltransferase activity
ES966_RS17900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES966_RS17910	COG2188	Transcriptional regulator
ES966_RS17915	COG1309	transcriptional regulator
ES966_RS17920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES966_RS17925	COG1950	PFAM Membrane protein of
ES966_RS17930	COG1983	PspC domain protein
ES966_RS17935	COG3595	metallopeptidase activity
ES966_RS17950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES966_RS17960	COG4897	Protein conserved in bacteria
ES966_RS17965	COG3848	Pyruvate phosphate dikinase
ES966_RS17965	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_RS17970	COG1309	transcriptional regulator
ES966_RS17975	COG2814	Major facilitator Superfamily
ES966_RS17990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_RS18000	COG0793	Belongs to the peptidase S41A family
ES966_RS18000	COG3409	Peptidoglycan-binding domain 1 protein
ES966_RS18005	COG3420	alginic acid biosynthetic process
ES966_RS18010	COG2177	Part of the ABC transporter FtsEX involved in
ES966_RS18015	COG2884	Cell division ATP-binding protein ftsE
ES966_RS18020	COG2010	Cytochrome c
ES966_RS18025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS18040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES966_RS18055	COG1516	flagellar protein fliS
ES966_RS18060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES966_RS18065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES966_RS18085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES966_RS18090	COG1256	bacterial-type flagellum assembly
ES966_RS18090	COG4786	Flagellar basal body rod
ES966_RS18095	COG3418	PFAM FlgN family protein
ES966_RS18100	COG2747	anti-sigma28 factor FlgM
ES966_RS18110	COG1040	competence protein
ES966_RS18120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES966_RS18125	COG1307	EDD domain protein, DegV family
ES966_RS18130	COG2197	response regulator
ES966_RS18135	COG4585	Histidine kinase
ES966_RS18140	COG1739	Uncharacterized protein family UPF0029
ES966_RS18145	COG1316	TRANSCRIPTIONal
ES966_RS18150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES966_RS18155	COG0438	transferase activity, transferring glycosyl groups
ES966_RS18160	COG1215	transferase activity, transferring glycosyl groups
ES966_RS18165	COG3206	protein involved in exopolysaccharide biosynthesis
ES966_RS18170	COG3307	-O-antigen
ES966_RS18175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES966_RS18180	COG0438	transferase activity, transferring glycosyl groups
ES966_RS18180	COG0297	glycogen (starch) synthase activity
ES966_RS18185	COG2244	polysaccharide biosynthetic process
ES966_RS18195	COG2247	cell wall binding repeat
ES966_RS18195	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_RS18200	COG2385	sporulation resulting in formation of a cellular spore
ES966_RS18200	COG2247	cell wall binding repeat
ES966_RS18210	COG1316	TRANSCRIPTIONal
ES966_RS18220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES966_RS18225	COG1134	teichoic acid transport
ES966_RS18240	COG0438	transferase activity, transferring glycosyl groups
ES966_RS18245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES966_RS18250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES966_RS18255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES966_RS18265	COG1482	cell wall glycoprotein biosynthetic process
ES966_RS18270	COG0697	spore germination
ES966_RS18290	COG2814	Major facilitator Superfamily
ES966_RS18295	COG1316	TRANSCRIPTIONal
ES966_RS18300	COG0561	phosphatase activity
ES966_RS18305	COG2433	Pfam Transposase IS66
ES966_RS18310	COG0791	NLP P60 protein
ES966_RS18320	COG2843	Capsule synthesis protein
ES966_RS18330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES966_RS18340	COG0697	spore germination
ES966_RS18345	COG0814	amino acid
ES966_RS18355	COG1609	Transcriptional regulator
ES966_RS18360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_RS18370	COG1129	ABC transporter
ES966_RS18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES966_RS18380	COG1879	ABC-type sugar transport system periplasmic component
ES966_RS18385	COG3103	Sh3 type 3 domain protein
ES966_RS18390	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_RS18395	COG3527	Alpha-acetolactate decarboxylase
ES966_RS18400	COG0028	Belongs to the TPP enzyme family
ES966_RS18405	COG0583	DNA-binding transcription factor activity
ES966_RS18410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES966_RS18425	COG5337	Spore coat protein CotH
ES966_RS18435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES966_RS18445	COG0405	Gamma-glutamyltransferase
ES966_RS18450	COG1522	sequence-specific DNA binding
ES966_RS18460	COG2059	Chromate
ES966_RS18470	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES966_RS18475	COG0583	DNA-binding transcription factor activity
ES966_RS18520	COG3878	Protein conserved in bacteria
ES966_RS18525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES966_RS18530	COG4464	protein tyrosine phosphatase activity
ES966_RS18535	COG0489	protein tyrosine kinase activity
ES966_RS18540	COG3944	biosynthesis protein
ES966_RS18555	COG4715	Zinc finger, swim domain protein
ES966_RS18560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES966_RS18565	COG0561	phosphatase activity
ES966_RS18570	COG1349	DNA-binding transcription factor activity
ES966_RS18575	COG0629	single-stranded DNA binding
ES966_RS18600	COG0457	Tetratricopeptide repeat
ES966_RS18605	COG4786	Flagellar basal body rod
ES966_RS18610	COG4786	Flagellar basal body rod
ES966_RS18615	COG1077	Cell shape determining protein MreB Mrl
ES966_RS18620	COG1609	Transcriptional regulator
ES966_RS18625	COG1846	Transcriptional regulator
ES966_RS18630	COG2814	Major facilitator Superfamily
ES966_RS18635	COG1953	Uracil, thiamine, allantoin
ES966_RS18640	COG0477	Major facilitator Superfamily
ES966_RS18645	COG1335	isochorismatase
ES966_RS18650	COG0004	ammonium transporteR
ES966_RS18655	COG0347	Belongs to the P(II) protein family
ES966_RS18660	COG0772	Belongs to the SEDS family
ES966_RS18665	COG0671	phosphoesterase, PA-phosphatase related
ES966_RS18675	COG0739	heme binding
ES966_RS18680	COG1247	-acetyltransferase
ES966_RS18695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_RS18705	COG0726	polysaccharide deacetylase
ES966_RS18715	COG1959	2 iron, 2 sulfur cluster binding
ES966_RS18730	COG0831	urea catabolic process
ES966_RS18740	COG1994	Peptidase M50
ES966_RS18745	COG0457	Tetratricopeptide repeat
ES966_RS18755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES966_RS18760	COG2304	oxidoreductase activity
ES966_RS18765	COG2304	oxidoreductase activity
ES966_RS18770	COG2385	sporulation resulting in formation of a cellular spore
ES966_RS18775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES966_RS18785	COG4836	Membrane
ES966_RS18855	COG0698	ribose 5-phosphate isomerase
ES966_RS18860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES966_RS18870	COG0009	L-threonylcarbamoyladenylate synthase
ES966_RS18875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES966_RS18895	COG2890	protein-(glutamine-N5) methyltransferase activity
ES966_RS18900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES966_RS18905	COG0346	lactoylglutathione lyase activity
ES966_RS18910	COG0789	Transcriptional regulator
ES966_RS18915	COG0679	Auxin Efflux Carrier
ES966_RS18920	COG0281	malic enzyme
ES966_RS18935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES966_RS18940	COG1494	fructose-1,6-bisphosphatase
ES966_RS18945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES966_RS18955	COG0191	fructose-bisphosphate aldolase activity
ES966_RS18960	COG2204	response regulator
ES966_RS18965	COG4821	SIS domain
ES966_RS18980	COG2181	nitrate reductase activity
ES966_RS18980	COG0247	lactate metabolic process
ES966_RS18985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_RS19000	COG1132	(ABC) transporter
ES966_RS19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_RS19015	COG2181	nitrate reductase activity
ES966_RS19020	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES966_RS19025	COG1140	nitrate reductase beta subunit
ES966_RS19030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES966_RS19035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_RS19045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_RS19050	COG2223	nitrite transmembrane transporter activity
ES966_RS19060	COG4506	Protein conserved in bacteria
ES966_RS19065	COG0457	Tetratricopeptide repeat
ES966_RS19075	COG0010	Belongs to the arginase family
ES966_RS19080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES966_RS19100	COG1994	Peptidase M50
ES966_RS19105	COG1942	4-Oxalocrotonate Tautomerase
ES966_RS19110	COG1846	Transcriptional regulator
ES966_RS19120	COG0531	amino acid
ES966_RS19125	COG3465	dGTPase activity
ES966_RS19130	COG1078	dGTPase activity
ES966_RS19145	COG1695	Transcriptional regulator
ES966_RS19155	COG1131	(ABC) transporter
ES966_RS19160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_RS19190	COG0583	DNA-binding transcription factor activity
ES966_RS19195	COG2855	membrane
ES966_RS19200	COG0280	phosphate acetyltransferase
ES966_RS19210	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS19215	COG0436	Aminotransferase
ES966_RS19245	COG2814	Major facilitator Superfamily
ES966_RS19250	COG2814	Major facilitator Superfamily
ES966_RS19255	COG0833	amino acid
ES966_RS19260	COG4187	Peptidase family M20/M25/M40
ES966_RS19265	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS19270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_RS19275	COG2205	protein histidine kinase activity
ES966_RS19280	COG0745	RESPONSE REGULATOR receiver
ES966_RS19295	COG1131	(ABC) transporter
ES966_RS19300	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES966_RS19305	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES966_RS19310	COG1088	dTDP-glucose 4,6-dehydratase activity
ES966_RS19315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES966_RS19320	COG3980	spore coat polysaccharide biosynthesis protein
ES966_RS19330	COG2089	acid synthase
ES966_RS19335	COG0456	acetyltransferase
ES966_RS19340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES966_RS19345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES966_RS19350	COG0463	Glycosyl transferase, family 2
ES966_RS19360	COG2363	Small membrane protein
ES966_RS19365	COG2233	PERMEase
ES966_RS19380	COG1216	Glycosyl transferase, family 2
ES966_RS19395	COG1695	Transcriptional regulator
ES966_RS19400	COG0351	phosphomethylpyrimidine kinase
ES966_RS19410	COG1621	beta-fructofuranosidase activity
ES966_RS19415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_RS19415	COG1263	PTS System
ES966_RS19420	COG3711	transcriptional antiterminator
ES966_RS19430	COG1404	Belongs to the peptidase S8 family
ES966_RS19435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_RS19440	COG0778	Nitroreductase
ES966_RS19445	COG0772	Belongs to the SEDS family
ES966_RS19450	COG0454	-acetyltransferase
ES966_RS19470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES966_RS19475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES966_RS19480	COG2261	transglycosylase associated protein
ES966_RS19485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES966_RS19490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES966_RS19495	COG2246	polysaccharide biosynthetic process
ES966_RS19500	COG1309	transcriptional regulator
ES966_RS19520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES966_RS19525	COG2837	iron assimilation
ES966_RS19530	COG2822	iron ion transport
ES966_RS19545	COG0583	DNA-binding transcription factor activity
ES966_RS19555	COG1346	cytolysis
ES966_RS19560	COG1131	(ABC) transporter
ES966_RS19590	COG4895	conserved protein (DUF2196)
ES966_RS19600	COG5504	Zn-dependent protease
ES966_RS19605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES966_RS19610	COG0346	lactoylglutathione lyase activity
ES966_RS19615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS19620	COG1404	Belongs to the peptidase S8 family
ES966_RS19625	COG1442	glycosyl transferase family 8
ES966_RS19630	COG2357	RelA SpoT domain protein
ES966_RS19635	COG1575	Belongs to the MenA family. Type 1 subfamily
ES966_RS19660	COG1696	Membrane protein involved in D-alanine export
ES966_RS19670	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES966_RS19675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_RS19680	COG1486	melibiose metabolic process
ES966_RS19685	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_RS19690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS19695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS19700	COG3711	transcriptional antiterminator
ES966_RS19700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_RS19715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS19720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_RS19730	COG0640	Transcriptional regulator
ES966_RS19735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES966_RS19740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS19745	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_RS19750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_RS19755	COG2723	6-phospho-beta-galactosidase activity
ES966_RS19760	COG1940	carbohydrate kinase activity
ES966_RS19765	COG1482	cell wall glycoprotein biosynthetic process
ES966_RS19775	COG0753	catalase activity
ES966_RS19780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES966_RS19785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES966_RS19790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES966_RS19795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES966_RS19800	COG4988	ABC transporter
ES966_RS19805	COG1294	oxidase, subunit
ES966_RS19810	COG1271	oxidase subunit
ES966_RS19815	COG3493	citrate carrier protein
ES966_RS19820	COG0726	polysaccharide deacetylase
ES966_RS19825	COG3842	ATPase activity
ES966_RS19830	COG2508	Transcriptional regulator
ES966_RS19835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS19845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES966_RS19855	COG4894	glucomannan catabolic process
ES966_RS19860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES966_RS19865	COG0500	methyltransferase
ES966_RS19870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_RS19885	COG0693	protein deglycase activity
ES966_RS19885	COG0753	catalase activity
ES966_RS19890	COG2851	Citrate transporter
ES966_RS19895	COG2273	Hydrolase Family 16
ES966_RS19905	COG2270	Major facilitator Superfamily
ES966_RS19910	COG0513	Belongs to the DEAD box helicase family
ES966_RS20000	COG3209	COG3209 Rhs family protein
ES966_RS20010	COG0697	spore germination
ES966_RS20015	COG0589	response to stress
ES966_RS20025	COG0494	nUDIX hydrolase
ES966_RS20030	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ES966_RS20060	COG0010	Belongs to the arginase family
ES966_RS20065	COG0833	amino acid
ES966_RS20075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_RS20085	COG2390	Transcriptional regulator
ES966_RS20115	COG1131	(ABC) transporter
ES966_RS20125	COG0561	phosphatase activity
ES966_RS20155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_RS20160	COG5294	Protein conserved in bacteria
ES966_RS20165	COG0577	efflux transmembrane transporter activity
ES966_RS20170	COG1136	(ABC) transporter
ES966_RS20175	COG2205	protein histidine kinase activity
ES966_RS20180	COG0745	RESPONSE REGULATOR receiver
ES966_RS20195	COG1082	Xylose isomerase domain protein TIM barrel
ES966_RS20205	COG2814	Major facilitator Superfamily
ES966_RS20235	COG1349	DNA-binding transcription factor activity
ES966_RS20240	COG0667	Aldo Keto reductase
ES966_RS20245	COG2814	Major facilitator Superfamily
ES966_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_RS20265	COG2197	response regulator
ES966_RS20270	COG4585	Histidine kinase
ES966_RS20275	COG3239	Fatty acid desaturase
ES966_RS20280	COG1309	transcriptional regulator
ES966_RS20285	COG1012	belongs to the aldehyde dehydrogenase family
ES966_RS20300	COG0640	Transcriptional regulator
ES966_RS20305	COG2814	Major facilitator Superfamily
ES966_RS20310	COG1714	RDD family
ES966_RS20320	COG0450	alkyl hydroperoxide reductase
ES966_RS20325	COG3634	alkyl hydroperoxide reductase activity
ES966_RS20330	COG3177	Filamentation induced by cAMP protein fic
ES966_RS20335	COG1113	amino acid transport
ES966_RS20345	COG2080	2 iron, 2 sulfur cluster binding
ES966_RS20360	COG2068	MobA-Related Protein
ES966_RS20385	COG1192	Involved in chromosome partitioning
ES966_RS20420	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES966_RS20425	COG0667	Aldo Keto reductase
ES966_RS20430	COG0456	acetyltransferase
ES966_RS20435	COG0457	Tetratricopeptide repeat
ES966_RS20440	COG0010	Belongs to the arginase family
ES966_RS20445	COG0833	amino acid
ES966_RS20450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES966_RS20455	COG5658	integral membrane protein
ES966_RS20460	COG0640	Transcriptional regulator
ES966_RS20465	COG3829	transcription factor binding
ES966_RS20475	COG0488	(ABC) transporter
ES966_RS20495	COG5002	protein histidine kinase activity
ES966_RS20495	COG3850	Histidine kinase
ES966_RS20500	COG0745	RESPONSE REGULATOR receiver
ES966_RS20510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_RS20515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES966_RS20520	COG4853	Protein conserved in bacteria
ES966_RS20525	COG4863	YycH protein
ES966_RS20530	COG5002	protein histidine kinase activity
ES966_RS20535	COG0745	RESPONSE REGULATOR receiver
ES966_RS20570	COG0346	lactoylglutathione lyase activity
ES966_RS20575	COG0305	Participates in initiation and elongation during chromosome replication
ES966_RS20590	COG3093	addiction module antidote protein HigA
ES966_RS20600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES966_RS20605	COG0297	glycogen (starch) synthase activity
ES966_RS20615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES966_RS20620	COG0438	transferase activity, transferring glycosyl groups
ES966_RS20630	COG2112	serine threonine protein kinase
ES966_RS20640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES966_RS20645	COG4241	membrane
ES966_RS20655	COG5577	PFAM Coat F domain
ES966_RS20660	COG1733	regulation of RNA biosynthetic process
ES966_RS20675	COG1621	beta-fructofuranosidase activity
ES966_RS20680	COG1621	beta-fructofuranosidase activity
ES966_RS20690	COG2318	DinB family
ES966_RS20695	COG2211	Major facilitator Superfamily
ES966_RS20710	COG0778	Nitroreductase
ES966_RS20715	COG1846	Transcriptional regulator
ES966_RS20720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_RS20725	COG1846	Transcriptional regulator
ES966_RS20730	COG2153	protein acetylation
ES966_RS20740	COG0546	phosphoglycolate phosphatase activity
ES966_RS20820	COG1131	(ABC) transporter
ES966_RS20835	COG1331	Highly conserved protein containing a thioredoxin domain
ES966_RS20840	COG1266	CAAX protease self-immunity
ES966_RS20845	COG0477	Major facilitator Superfamily
ES966_RS20845	COG2814	Major facilitator Superfamily
ES966_RS20850	COG0346	lactoylglutathione lyase activity
ES966_RS20855	COG1609	Transcriptional regulator
ES966_RS20865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES966_RS20870	COG2169	Transcriptional regulator
ES966_RS20880	COG0629	single-stranded DNA binding
ES966_RS20890	COG0012	GTP binding
ES966_RS20895	COG0243	molybdopterin cofactor binding
ES966_RS20900	COG4481	Protein conserved in bacteria
ES966_RS20905	COG3949	Membrane
ES966_RS20920	COG1475	DNA binding
ES966_RS20925	COG1192	Involved in chromosome partitioning
ES966_RS20950	COG1847	R3H domain protein
ES966_RS20955	COG0706	membrane insertase activity