locus-tag	class	description
PF996_RS00010	COG0592	DNA-directed DNA polymerase activity
PF996_RS00015	COG2501	S4 domain
PF996_RS00030	COG0187	DNA topoisomerase II activity
PF996_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF996_RS00070	COG0516	GMP reductase activity
PF996_RS00070	COG0517	IMP dehydrogenase activity
PF996_RS00075	COG1686	Belongs to the peptidase S11 family
PF996_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
PF996_RS00105	COG1428	Deoxynucleoside kinase
PF996_RS00110	COG1428	Deoxynucleoside kinase
PF996_RS00115	COG1388	LysM domain
PF996_RS00115	COG3858	chitin binding
PF996_RS00120	COG1335	isochorismatase
PF996_RS00125	COG0590	tRNA wobble adenosine to inosine editing
PF996_RS00135	COG1132	(ABC) transporter
PF996_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF996_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PF996_RS00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
PF996_RS00200	COG3853	Toxic anion resistance protein (TelA)
PF996_RS00205	COG1982	Orn Lys Arg decarboxylase major
PF996_RS00215	COG3870	Protein conserved in bacteria
PF996_RS00220	COG1728	Protein conserved in bacteria
PF996_RS00225	COG0470	DNA polymerase III
PF996_RS00230	COG1774	PSP1 C-terminal conserved region
PF996_RS00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PF996_RS00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PF996_RS00255	COG2002	toxin-antitoxin pair type II binding
PF996_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF996_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF996_RS00265	COG0084	hydrolase, TatD family'
PF996_RS00270	COG3583	domain protein
PF996_RS00270	COG3584	3D domain protein
PF996_RS00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF996_RS00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF996_RS00290	COG4466	Protein conserved in bacteria
PF996_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF996_RS00310	COG0251	oxidation-reduction process
PF996_RS00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF996_RS00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF996_RS00350	COG2002	toxin-antitoxin pair type II binding
PF996_RS00355	COG2244	polysaccharide biosynthetic process
PF996_RS00360	COG3956	TIGRFAM MazG family protein
PF996_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF996_RS00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF996_RS00385	COG1098	S1 RNA binding domain
PF996_RS00400	COG2208	phosphoserine phosphatase activity
PF996_RS00405	COG2304	oxidoreductase activity
PF996_RS00410	COG0515	serine threonine protein kinase
PF996_RS00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PF996_RS00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF996_RS00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF996_RS00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF996_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF996_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
PF996_RS00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF996_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF996_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF996_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF996_RS00480	COG1396	sequence-specific DNA binding
PF996_RS00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF996_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PF996_RS00570	COG4463	regulation of RNA biosynthetic process
PF996_RS00575	COG3880	PFAM UvrB UvrC protein
PF996_RS00585	COG0542	response to heat
PF996_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PF996_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PF996_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
PF996_RS00620	COG1045	serine acetyltransferase
PF996_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PF996_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF996_RS00640	COG3688	RNA-binding protein containing a PIN domain
PF996_RS00645	COG1595	DNA-templated transcription, initiation
PF996_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF996_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
PF996_RS00685	COG2813	Specifically methylates the guanine in position
PF996_RS00700	COG1358	cellular component organization or biogenesis
PF996_RS00725	COG0596	Alpha beta hydrolase
PF996_RS00835	COG0201	protein transport
PF996_RS00845	COG0024	Methionine aminopeptidase
PF996_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF996_RS00885	COG1122	ATPase activity
PF996_RS00890	COG1122	ATPase activity
PF996_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF996_RS00915	COG2226	methyltransferase
PF996_RS00920	COG2318	DinB family
PF996_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS00935	COG0489	protein tyrosine kinase activity
PF996_RS00945	COG2194	sulfuric ester hydrolase activity
PF996_RS00950	COG0726	polysaccharide deacetylase
PF996_RS01010	COG0738	Major facilitator superfamily
PF996_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF996_RS01025	COG1063	alcohol dehydrogenase
PF996_RS01030	COG0659	secondary active sulfate transmembrane transporter activity
PF996_RS01035	COG0385	Bile acid
PF996_RS01040	COG2819	hydrolase of the alpha beta superfamily
PF996_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF996_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF996_RS01060	COG2207	Transcriptional regulator
PF996_RS01065	COG3876	Protein conserved in bacteria
PF996_RS01070	COG1472	Belongs to the glycosyl hydrolase 3 family
PF996_RS01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF996_RS01080	COG1263	PTS System
PF996_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF996_RS01095	COG1683	Conserved Protein
PF996_RS01125	COG1595	DNA-templated transcription, initiation
PF996_RS01130	COG5662	AntiSigma factor
PF996_RS01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF996_RS01140	COG4856	YbbR-like protein
PF996_RS01165	COG0515	serine threonine protein kinase
PF996_RS01175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF996_RS01185	COG1346	cytolysis
PF996_RS01190	COG1380	Effector of murein hydrolase LrgA
PF996_RS01195	COG1846	Transcriptional regulator
PF996_RS01200	COG1113	amino acid transport
PF996_RS01205	COG1011	Hydrolase
PF996_RS01210	COG4585	Histidine kinase
PF996_RS01215	COG2197	response regulator
PF996_RS01220	COG1131	(ABC) transporter
PF996_RS01260	COG0531	amino acid
PF996_RS01285	COG0584	glycerophosphoryl diester phosphodiesterase
PF996_RS01290	COG2271	Major facilitator Superfamily
PF996_RS01300	COG2368	4-hydroxyphenylacetate
PF996_RS01310	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS01325	COG0371	Dehydrogenase
PF996_RS01335	COG1183	phosphatidylcholine synthase activity
PF996_RS01340	COG0586	Pfam SNARE associated Golgi protein
PF996_RS01345	COG0688	phosphatidylethanolamine metabolic process
PF996_RS01360	COG1301	dicarboxylic acid transport
PF996_RS01365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF996_RS01370	COG0833	amino acid
PF996_RS01375	COG2040	homocysteine
PF996_RS01380	COG1115	amino acid carrier protein
PF996_RS01385	COG2066	Belongs to the glutaminase family
PF996_RS01395	COG0784	Response regulator, receiver
PF996_RS01400	COG3173	Aminoglycoside phosphotransferase
PF996_RS01415	COG3773	Cell wall hydrolase
PF996_RS01420	COG3540	Alkaline phosphatase
PF996_RS01425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF996_RS01430	COG0805	protein transport
PF996_RS01440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF996_RS01445	COG0477	Major facilitator Superfamily
PF996_RS01450	COG1309	transcriptional regulator
PF996_RS01455	COG0252	asparaginase activity
PF996_RS01465	COG1405	negative regulation of cell septum assembly
PF996_RS01465	COG3012	SEC-C Motif Domain Protein
PF996_RS01470	COG0667	Aldo Keto reductase
PF996_RS01480	COG1595	DNA-templated transcription, initiation
PF996_RS01485	COG1595	DNA-templated transcription, initiation
PF996_RS01490	COG1876	peptidase activity
PF996_RS01495	COG0457	Tetratricopeptide repeat
PF996_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS01510	COG0366	Alpha amylase catalytic
PF996_RS01515	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF996_RS01520	COG1121	(ABC) transporter
PF996_RS01525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF996_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS01535	COG2310	stress, protein
PF996_RS01540	COG2310	stress, protein
PF996_RS01545	COG2310	stress, protein
PF996_RS01550	COG0861	Integral membrane protein TerC family
PF996_RS01560	COG3853	Toxic anion resistance protein (TelA)
PF996_RS01565	COG0477	Major facilitator Superfamily
PF996_RS01570	COG0517	IMP dehydrogenase activity
PF996_RS01570	COG4175	Glycine betaine
PF996_RS01575	COG4176	ABC-type proline glycine betaine transport system permease component
PF996_RS01580	COG2113	Glycine betaine
PF996_RS01585	COG1473	amidohydrolase
PF996_RS01590	COG1288	antiporter activity
PF996_RS01600	COG0366	Alpha amylase catalytic
PF996_RS01665	COG2814	Major facilitator Superfamily
PF996_RS01670	COG1846	Transcriptional regulator
PF996_RS01675	COG1280	lysine exporter protein (LysE YggA)
PF996_RS01680	COG3403	YqcI/YcgG family
PF996_RS01685	COG1113	amino acid transport
PF996_RS01690	COG3665	Urea carboxylase-associated protein
PF996_RS01705	COG1660	Displays ATPase and GTPase activities
PF996_RS01715	COG2271	Major facilitator Superfamily
PF996_RS01720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PF996_RS01725	COG3458	cephalosporin-C deacetylase activity
PF996_RS01730	COG3541	Predicted nucleotidyltransferase
PF996_RS01735	COG0506	proline dehydrogenase activity
PF996_RS01740	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS01745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF996_RS01750	COG2508	Transcriptional regulator
PF996_RS01760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF996_RS01760	COG1587	Uroporphyrinogen-III synthase
PF996_RS01765	COG2146	nitrite reductase [NAD(P)H] activity
PF996_RS01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF996_RS01775	COG0243	molybdopterin cofactor binding
PF996_RS01780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF996_RS01785	COG2223	nitrite transmembrane transporter activity
PF996_RS01790	COG0523	cobalamin synthesis protein
PF996_RS01795	COG1063	alcohol dehydrogenase
PF996_RS01800	COG1714	RDD family
PF996_RS01810	COG2723	6-phospho-beta-galactosidase activity
PF996_RS01820	COG3209	COG3209 Rhs family protein
PF996_RS01825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF996_RS01830	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PF996_RS01835	COG1733	regulation of RNA biosynthetic process
PF996_RS01840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS01860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS01865	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF996_RS01880	COG2364	Membrane
PF996_RS01885	COG1126	abc transporter atp-binding protein
PF996_RS01890	COG0765	amino acid transport
PF996_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS01900	COG0583	DNA-binding transcription factor activity
PF996_RS01905	COG0163	prenyltransferase activity
PF996_RS01910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PF996_RS01930	COG3104	oligopeptide transport
PF996_RS01935	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS01945	COG0697	spore germination
PF996_RS01955	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF996_RS01960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS01965	COG0456	acetyltransferase
PF996_RS01970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS01975	COG0765	amino acid transport
PF996_RS01980	COG1126	abc transporter atp-binding protein
PF996_RS01985	COG1473	amidohydrolase
PF996_RS01990	COG2079	MmgE PrpD family protein
PF996_RS01995	COG1136	(ABC) transporter
PF996_RS02000	COG0577	efflux transmembrane transporter activity
PF996_RS02005	COG0745	RESPONSE REGULATOR receiver
PF996_RS02010	COG5002	protein histidine kinase activity
PF996_RS02010	COG3850	Histidine kinase
PF996_RS02015	COG0457	Tetratricopeptide repeat
PF996_RS02030	COG0527	aspartate kinase activity
PF996_RS02035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS02040	COG4605	iron ion homeostasis
PF996_RS02045	COG4604	ABC transporter, ATP-binding protein
PF996_RS02050	COG4607	ABC-type enterochelin transport system periplasmic component
PF996_RS02055	COG2814	Major facilitator Superfamily
PF996_RS02060	COG1309	transcriptional regulator
PF996_RS02065	COG0778	Nitroreductase
PF996_RS02070	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF996_RS02075	COG0640	Transcriptional regulator
PF996_RS02080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS02085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF996_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS02095	COG4975	Glucose uptake
PF996_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS02105	COG4549	nuclear export factor GLE1
PF996_RS02110	COG2372	response to copper ion
PF996_RS02110	COG1276	copper resistance
PF996_RS02115	COG1349	DNA-binding transcription factor activity
PF996_RS02125	COG2213	PTS system mannitol-specific
PF996_RS02130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS02140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF996_RS02150	COG0561	phosphatase activity
PF996_RS02160	COG1914	H( )-stimulated, divalent metal cation uptake system
PF996_RS02170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PF996_RS02175	COG1984	allophanate hydrolase subunit 2
PF996_RS02180	COG1414	Transcriptional regulator
PF996_RS02185	COG2755	lipolytic protein G-D-S-L family
PF996_RS02195	COG2329	Antibiotic biosynthesis monooxygenase
PF996_RS02200	COG0768	penicillin binding
PF996_RS02205	COG4989	oxidoreductase activity
PF996_RS02210	COG3711	transcriptional antiterminator
PF996_RS02215	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS02225	COG1917	Cupin 2, conserved barrel domain protein
PF996_RS02230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF996_RS02235	COG3871	stress protein (general stress protein 26)
PF996_RS02245	COG2814	Major facilitator Superfamily
PF996_RS02250	COG1522	sequence-specific DNA binding
PF996_RS02255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF996_RS02255	COG0551	DNA topoisomerase type I activity
PF996_RS02260	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PF996_RS02285	COG0531	amino acid
PF996_RS02290	COG0494	nUDIX hydrolase
PF996_RS02295	COG0028	Belongs to the TPP enzyme family
PF996_RS02315	COG0457	Tetratricopeptide repeat
PF996_RS02345	COG1914	H( )-stimulated, divalent metal cation uptake system
PF996_RS02365	COG2076	Multidrug Resistance protein
PF996_RS02370	COG2217	Heavy metal translocating P-type atpase
PF996_RS02375	COG3729	General stress protein
PF996_RS02380	COG0662	Cupin 2, conserved barrel domain protein
PF996_RS02385	COG2329	Antibiotic biosynthesis monooxygenase
PF996_RS02390	COG3546	catalase activity
PF996_RS02395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PF996_RS02400	COG3290	protein histidine kinase activity
PF996_RS02405	COG4565	transcriptional regulatory protein
PF996_RS02410	COG1301	dicarboxylic acid transport
PF996_RS02415	COG0628	permease
PF996_RS02420	COG1131	(ABC) transporter
PF996_RS02425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF996_RS02435	COG1960	acyl-CoA dehydrogenase activity
PF996_RS02450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF996_RS02455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF996_RS02470	COG0513	Belongs to the DEAD box helicase family
PF996_RS02475	COG3402	PFAM membrane-flanked domain
PF996_RS02480	COG3428	Bacterial PH domain
PF996_RS02485	COG0705	Rhomboid family
PF996_RS02495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF996_RS02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF996_RS02505	COG0864	Transcriptional regulator
PF996_RS02510	COG2337	Toxic component of a toxin-antitoxin (TA) module
PF996_RS02515	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS02520	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS02525	COG2172	sigma factor antagonist activity
PF996_RS02530	COG2208	phosphoserine phosphatase activity
PF996_RS02535	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS02545	COG1191	sigma factor activity
PF996_RS02550	COG2208	phosphoserine phosphatase activity
PF996_RS02605	COG0582	viral genome integration into host DNA
PF996_RS02610	COG2856	Zn peptidase
PF996_RS02615	COG1396	sequence-specific DNA binding
PF996_RS02640	COG1674	ftsk spoiiie
PF996_RS02645	COG2946	Replication initiation factor
PF996_RS02700	COG0433	COG0433 Predicted ATPase
PF996_RS02710	COG5644	endopeptidase inhibitor activity
PF996_RS02715	COG0791	NLP P60 protein
PF996_RS02715	COG0741	lytic transglycosylase activity
PF996_RS02735	COG0457	Tetratricopeptide repeat
PF996_RS02745	COG5444	nuclease activity
PF996_RS02750	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF996_RS02770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF996_RS02775	COG0477	Major facilitator Superfamily
PF996_RS02790	COG2030	dehydratase
PF996_RS02805	COG1959	2 iron, 2 sulfur cluster binding
PF996_RS02810	COG2910	NAD(P)H-binding
PF996_RS02820	COG1309	transcriptional regulator
PF996_RS02825	COG3239	Fatty acid desaturase
PF996_RS02830	COG1278	Cold shock
PF996_RS02835	COG1329	Transcriptional regulator
PF996_RS02840	COG1794	racemase activity, acting on amino acids and derivatives
PF996_RS02855	COG3621	Patatin-like phospholipase
PF996_RS02865	COG0662	Cupin 2, conserved barrel domain protein
PF996_RS02880	COG0277	FAD linked oxidase domain protein
PF996_RS02905	COG0662	Cupin 2, conserved barrel domain protein
PF996_RS02910	COG2318	DinB family
PF996_RS02915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF996_RS02940	COG1064	alcohol dehydrogenase
PF996_RS02945	COG0789	Transcriptional regulator
PF996_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS02970	COG2814	Major facilitator Superfamily
PF996_RS02975	COG1309	transcriptional regulator
PF996_RS02980	COG0697	spore germination
PF996_RS02985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS02990	COG5577	PFAM Coat F domain
PF996_RS03000	COG1063	alcohol dehydrogenase
PF996_RS03005	COG5577	PFAM Coat F domain
PF996_RS03015	COG0738	Major facilitator superfamily
PF996_RS03040	COG4585	Histidine kinase
PF996_RS03045	COG2197	response regulator
PF996_RS03050	COG2409	Drug exporters of the RND superfamily
PF996_RS03055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PF996_RS03060	COG0488	(ABC) transporter
PF996_RS03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF996_RS03070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS03085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF996_RS03095	COG0730	response to heat
PF996_RS03100	COG0456	acetyltransferase
PF996_RS03105	COG0789	Transcriptional regulator
PF996_RS03105	COG4978	Transcriptional regulator
PF996_RS03110	COG0697	spore germination
PF996_RS03115	COG1051	belongs to the nudix hydrolase family
PF996_RS03120	COG2226	methyltransferase
PF996_RS03125	COG0473	3-isopropylmalate dehydrogenase activity
PF996_RS03130	COG1802	Transcriptional regulator
PF996_RS03135	COG1819	glycosyl
PF996_RS03150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF996_RS03160	COG1388	LysM domain
PF996_RS03165	COG2814	Major facilitator Superfamily
PF996_RS03170	COG2188	Transcriptional regulator
PF996_RS03175	COG2186	Transcriptional regulator
PF996_RS03180	COG2807	transmembrane transport
PF996_RS03185	COG2076	Multidrug Resistance protein
PF996_RS03190	COG2076	Multidrug Resistance protein
PF996_RS03195	COG1309	transcriptional regulator
PF996_RS03200	COG0531	amino acid
PF996_RS03210	COG3832	glyoxalase III activity
PF996_RS03215	COG0604	alcohol dehydrogenase
PF996_RS03225	COG2814	Major facilitator Superfamily
PF996_RS03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF996_RS03270	COG0802	atpase or kinase
PF996_RS03275	COG1214	PFAM Peptidase M22, glycoprotease
PF996_RS03280	COG0456	acetyltransferase
PF996_RS03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PF996_RS03290	COG0488	(ABC) transporter
PF996_RS03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF996_RS03310	COG0805	protein transport
PF996_RS03320	COG1266	CAAX protease self-immunity
PF996_RS03335	COG0156	8-amino-7-oxononanoate synthase activity
PF996_RS03355	COG3403	YqcI/YcgG family
PF996_RS03370	COG2814	Major facilitator Superfamily
PF996_RS03375	COG0457	Tetratricopeptide repeat
PF996_RS03380	COG1063	alcohol dehydrogenase
PF996_RS03385	COG2211	Major facilitator Superfamily
PF996_RS03390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF996_RS03400	COG1842	Phage shock protein A
PF996_RS03405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF996_RS03410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF996_RS03415	COG4260	virion core protein, lumpy skin disease virus
PF996_RS03420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PF996_RS03420	COG2755	lipolytic protein G-D-S-L family
PF996_RS03430	COG1595	DNA-templated transcription, initiation
PF996_RS03435	COG1063	alcohol dehydrogenase
PF996_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF996_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
PF996_RS03465	COG1113	amino acid transport
PF996_RS03470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF996_RS03475	COG0714	Associated with various cellular activities
PF996_RS03480	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PF996_RS03485	COG1305	Transglutaminase-like
PF996_RS03515	COG1674	ftsk spoiiie
PF996_RS03545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF996_RS03550	COG1181	Belongs to the D-alanine--D-alanine ligase family
PF996_RS03560	COG2211	Major facilitator Superfamily
PF996_RS03575	COG2252	PERMEase
PF996_RS03580	COG3064	Membrane
PF996_RS03600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PF996_RS03605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF996_RS03610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF996_RS03615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PF996_RS03620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF996_RS03635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PF996_RS03645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF996_RS03650	COG0138	bifunctional purine biosynthesis protein purh
PF996_RS03655	COG0151	Belongs to the GarS family
PF996_RS03665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF996_RS03670	COG1470	cell adhesion involved in biofilm formation
PF996_RS03675	COG4496	protein, YerC YecD
PF996_RS03680	COG0069	glutamate synthase activity
PF996_RS03690	COG0210	DNA helicase
PF996_RS03700	COG4851	CamS sex pheromone cAM373 precursor
PF996_RS03705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF996_RS03710	COG1285	pathogenesis
PF996_RS03715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF996_RS03735	COG1309	transcriptional regulator
PF996_RS03740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF996_RS03745	COG1597	lipid kinase activity
PF996_RS03750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF996_RS03755	COG2197	response regulator
PF996_RS03765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS03775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF996_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS03790	COG1131	(ABC) transporter
PF996_RS03830	COG5444	nuclease activity
PF996_RS03860	COG3546	catalase activity
PF996_RS03865	COG0454	-acetyltransferase
PF996_RS03875	COG2323	membrane
PF996_RS03880	COG2329	Antibiotic biosynthesis monooxygenase
PF996_RS03890	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS03895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF996_RS03905	COG4208	sulfate ABC transporter
PF996_RS03915	COG5583	Uncharacterized small protein (DUF2292)
PF996_RS03920	COG0196	riboflavin kinase activity
PF996_RS03925	COG0670	Belongs to the BI1 family
PF996_RS03930	COG1846	Transcriptional regulator
PF996_RS03935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF996_RS03945	COG2124	cytochrome p450
PF996_RS03945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF996_RS03960	COG1131	(ABC) transporter
PF996_RS03970	COG1368	sulfuric ester hydrolase activity
PF996_RS03975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF996_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS03985	COG1442	glycosyl transferase family 8
PF996_RS03990	COG1216	Glycosyl transferase, family 2
PF996_RS03995	COG1442	glycosyl transferase family 8
PF996_RS04000	COG2223	nitrite transmembrane transporter activity
PF996_RS04005	COG0531	amino acid
PF996_RS04010	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS04015	COG0840	transmembrane signaling receptor activity
PF996_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS04025	COG0457	Tetratricopeptide repeat
PF996_RS04025	COG0463	Glycosyl transferase, family 2
PF996_RS04030	COG0488	(ABC) transporter
PF996_RS04035	COG0789	Transcriptional regulator
PF996_RS04040	COG2814	Major facilitator Superfamily
PF996_RS04045	COG0488	(ABC) transporter
PF996_RS04050	COG0513	Belongs to the DEAD box helicase family
PF996_RS04055	COG0456	acetyltransferase
PF996_RS04060	COG2130	NADP-dependent
PF996_RS04075	COG3866	Pectate lyase
PF996_RS04080	COG0471	metal ion transport
PF996_RS04105	COG3290	protein histidine kinase activity
PF996_RS04110	COG4565	transcriptional regulatory protein
PF996_RS04115	COG3181	Tripartite tricarboxylate transporter family receptor
PF996_RS04120	COG2851	Citrate transporter
PF996_RS04125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS04130	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PF996_RS04140	COG2258	MOSC domain
PF996_RS04160	COG0024	Methionine aminopeptidase
PF996_RS04165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS04165	COG1263	PTS System
PF996_RS04175	COG1368	sulfuric ester hydrolase activity
PF996_RS04185	COG0071	Belongs to the small heat shock protein (HSP20) family
PF996_RS04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS04200	COG1263	PTS System
PF996_RS04205	COG0366	Alpha amylase catalytic
PF996_RS04210	COG2188	Transcriptional regulator
PF996_RS04215	COG0778	Nitroreductase
PF996_RS04230	COG0737	Belongs to the 5'-nucleotidase family
PF996_RS04235	COG0693	protein deglycase activity
PF996_RS04240	COG1609	Transcriptional regulator
PF996_RS04255	COG2814	Major facilitator Superfamily
PF996_RS04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF996_RS04270	COG4980	gas vesicle protein
PF996_RS04275	COG1295	ribonuclease BN
PF996_RS04280	COG0477	Major facilitator Superfamily
PF996_RS04285	COG0387	Pfam Sodium calcium exchanger
PF996_RS04295	COG0668	transmembrane transport
PF996_RS04300	COG0535	radical SAM domain protein
PF996_RS04310	COG0726	polysaccharide deacetylase
PF996_RS04315	COG2084	Dehydrogenase
PF996_RS04325	COG0598	Magnesium transport protein CorA
PF996_RS04330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF996_RS04335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF996_RS04350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF996_RS04355	COG4637	Psort location Cytoplasmic, score
PF996_RS04360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF996_RS04365	COG0022	dehydrogenase e1 component
PF996_RS04370	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF996_RS04375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF996_RS04380	COG3284	Transcriptional regulator
PF996_RS04390	COG1486	melibiose metabolic process
PF996_RS04395	COG1737	Transcriptional regulator
PF996_RS04400	COG1263	PTS System
PF996_RS04400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS04405	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS04410	COG1132	(ABC) transporter
PF996_RS04415	COG1132	(ABC) transporter
PF996_RS04420	COG2259	Doxx family
PF996_RS04425	COG2514	catechol 2,3-dioxygenase activity
PF996_RS04435	COG1695	Transcriptional regulator
PF996_RS04440	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF996_RS04445	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
PF996_RS04450	COG3848	Pyruvate phosphate dikinase
PF996_RS04450	COG0574	Belongs to the PEP-utilizing enzyme family
PF996_RS04455	COG2732	(Barnase) inhibitor
PF996_RS04460	COG2318	DinB family
PF996_RS04465	COG2814	Major facilitator Superfamily
PF996_RS04470	COG1846	Transcriptional regulator
PF996_RS04475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PF996_RS04475	COG0392	lysyltransferase activity
PF996_RS04480	COG0384	phenazine biosynthesis protein PhzF
PF996_RS04485	COG0778	Nitroreductase
PF996_RS04500	COG1090	epimerase
PF996_RS04515	COG2814	Major facilitator Superfamily
PF996_RS04525	COG3591	Belongs to the peptidase S1B family
PF996_RS04540	COG3103	Sh3 type 3 domain protein
PF996_RS04545	COG5658	integral membrane protein
PF996_RS04550	COG0596	Alpha beta hydrolase
PF996_RS04555	COG0463	Glycosyl transferase, family 2
PF996_RS04560	COG4485	Bacterial membrane protein, YfhO
PF996_RS04565	COG1988	membrane-bound metal-dependent
PF996_RS04570	COG1194	a g-specific adenine glycosylase
PF996_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS04600	COG1132	(ABC) transporter
PF996_RS04605	COG4129	membrane
PF996_RS04615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF996_RS04620	COG0735	belongs to the Fur family
PF996_RS04750	COG3328	transposase activity
PF996_RS04770	COG3340	Belongs to the peptidase S51 family
PF996_RS04780	COG0277	FAD linked oxidase domain protein
PF996_RS04790	COG0747	negative chemotaxis
PF996_RS04795	COG0601	transmembrane transport
PF996_RS04800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF996_RS04805	COG0444	Belongs to the ABC transporter superfamily
PF996_RS04810	COG4608	Belongs to the ABC transporter superfamily
PF996_RS04815	COG0753	catalase activity
PF996_RS04825	COG1116	anion transmembrane transporter activity
PF996_RS04830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF996_RS04835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF996_RS04860	COG1476	TRANSCRIPTIONal
PF996_RS04870	COG3382	B3 4 domain protein
PF996_RS04875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF996_RS04885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF996_RS04890	COG0789	Transcriptional regulator
PF996_RS04895	COG1664	Polymer-forming cytoskeletal
PF996_RS04900	COG1664	Polymer-forming cytoskeletal
PF996_RS04905	COG2766	serine protein kinase
PF996_RS04915	COG1846	Transcriptional regulator
PF996_RS04920	COG1566	PFAM secretion protein HlyD family protein
PF996_RS04925	COG2814	Major facilitator Superfamily
PF996_RS04930	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF996_RS04945	COG1725	Transcriptional regulator
PF996_RS04950	COG1131	(ABC) transporter
PF996_RS04955	COG1131	(ABC) transporter
PF996_RS04960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF996_RS04965	COG1278	Cold shock
PF996_RS04970	COG1464	Belongs to the NlpA lipoprotein family
PF996_RS04975	COG3706	GGDEF domain
PF996_RS04980	COG1823	symporter activity
PF996_RS05000	COG5577	PFAM Coat F domain
PF996_RS05005	COG0737	Belongs to the 5'-nucleotidase family
PF996_RS05005	COG1525	nuclease
PF996_RS05005	COG4085	toxin activity
PF996_RS05010	COG3764	Sortase (surface protein transpeptidase)
PF996_RS05015	COG0564	pseudouridine synthase activity
PF996_RS05025	COG0517	IMP dehydrogenase activity
PF996_RS05030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF996_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF996_RS05035	COG3153	acetyltransferase
PF996_RS05045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF996_RS05050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PF996_RS05055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF996_RS05065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PF996_RS05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF996_RS05075	COG2203	Gaf domain
PF996_RS05075	COG4585	Histidine kinase
PF996_RS05080	COG2197	response regulator
PF996_RS05085	COG0431	NADPH-dependent FMN reductase
PF996_RS05100	COG0791	NLP P60 protein
PF996_RS05100	COG1388	LysM domain
PF996_RS05105	COG1959	2 iron, 2 sulfur cluster binding
PF996_RS05115	COG2719	SpoVR family
PF996_RS05120	COG1785	Belongs to the alkaline phosphatase family
PF996_RS05125	COG0791	NLP P60 protein
PF996_RS05125	COG1388	LysM domain
PF996_RS05130	COG0583	DNA-binding transcription factor activity
PF996_RS05135	COG0372	Belongs to the citrate synthase family
PF996_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS05145	COG0531	amino acid
PF996_RS05150	COG0733	neurotransmitter:sodium symporter activity
PF996_RS05165	COG1595	DNA-templated transcription, initiation
PF996_RS05170	COG0204	Acyl-transferase
PF996_RS05175	COG1253	flavin adenine dinucleotide binding
PF996_RS05180	COG0789	Transcriptional regulator
PF996_RS05185	COG0436	Aminotransferase
PF996_RS05190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF996_RS05195	COG1253	flavin adenine dinucleotide binding
PF996_RS05200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF996_RS05205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF996_RS05210	COG0584	glycerophosphoryl diester phosphodiesterase
PF996_RS05220	COG0668	transmembrane transport
PF996_RS05225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF996_RS05230	COG0726	polysaccharide deacetylase
PF996_RS05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF996_RS05240	COG3226	Transcriptional regulator
PF996_RS05250	COG0589	response to stress
PF996_RS05255	COG1132	(ABC) transporter
PF996_RS05260	COG1132	(ABC) transporter
PF996_RS05265	COG0702	epimerase
PF996_RS05285	COG0189	ligase activity
PF996_RS05290	COG0189	ligase activity
PF996_RS05305	COG4335	DNA alkylation repair
PF996_RS05310	COG0561	phosphatase activity
PF996_RS05315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF996_RS05325	COG0475	glutathione-regulated potassium exporter activity
PF996_RS05330	COG0490	domain, Protein
PF996_RS05340	COG1024	Enoyl-CoA hydratase
PF996_RS05350	COG4152	abc transporter atp-binding protein
PF996_RS05355	COG1668	transmembrane transport
PF996_RS05360	COG0420	3'-5' exonuclease activity
PF996_RS05365	COG4717	serine-type aminopeptidase activity
PF996_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF996_RS05415	COG4980	gas vesicle protein
PF996_RS05430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PF996_RS05435	COG0537	adenosine 5'-monophosphoramidase activity
PF996_RS05440	COG1131	(ABC) transporter
PF996_RS05445	COG4473	ABC transporter
PF996_RS05455	COG1473	amidohydrolase
PF996_RS05460	COG3069	C4-dicarboxylate transmembrane transporter activity
PF996_RS05465	COG2329	Antibiotic biosynthesis monooxygenase
PF996_RS05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF996_RS05480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PF996_RS05485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PF996_RS05490	COG1309	transcriptional regulator
PF996_RS05495	COG1511	domain protein
PF996_RS05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF996_RS05510	COG1363	Peptidase, m42
PF996_RS05515	COG1301	dicarboxylic acid transport
PF996_RS05525	COG1234	tRNA 3'-trailer cleavage
PF996_RS05530	COG0095	Lipoate-protein ligase
PF996_RS05535	COG0702	epimerase
PF996_RS05540	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS05550	COG0501	Belongs to the peptidase M48B family
PF996_RS05555	COG1404	Belongs to the peptidase S8 family
PF996_RS05560	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF996_RS05565	COG0406	alpha-ribazole phosphatase activity
PF996_RS05570	COG0183	Belongs to the thiolase family
PF996_RS05575	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS05580	COG1268	BioY protein
PF996_RS05585	COG0840	transmembrane signaling receptor activity
PF996_RS05590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF996_RS05590	COG0723	plastoquinol--plastocyanin reductase activity
PF996_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS05605	COG4903	ComK protein
PF996_RS05615	COG5646	InterPro IPR014922
PF996_RS05640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF996_RS05655	COG0398	Pfam SNARE associated Golgi protein
PF996_RS05660	COG0681	Belongs to the peptidase S26 family
PF996_RS05665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF996_RS05670	COG1846	Transcriptional regulator
PF996_RS05675	COG3180	Ammonia monooxygenase
PF996_RS05680	COG2814	Major facilitator Superfamily
PF996_RS05690	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PF996_RS05695	COG2323	membrane
PF996_RS05710	COG0420	3'-5' exonuclease activity
PF996_RS05715	COG0419	ATPase involved in DNA repair
PF996_RS05720	COG1403	HNH endonuclease
PF996_RS05760	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF996_RS05780	COG0367	asparagine synthase
PF996_RS05785	COG1562	ergosterol biosynthetic process
PF996_RS05790	COG0534	Mate efflux family protein
PF996_RS05795	COG1917	Cupin 2, conserved barrel domain protein
PF996_RS05795	COG2207	Transcriptional regulator
PF996_RS05800	COG1609	Transcriptional regulator
PF996_RS05805	COG0673	inositol 2-dehydrogenase activity
PF996_RS05810	COG2318	DinB family
PF996_RS05815	COG1279	arginine transmembrane transporter activity
PF996_RS05820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS05825	COG1357	PFAM Pentapeptide repeats (8 copies)
PF996_RS05830	COG2153	protein acetylation
PF996_RS05835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF996_RS05835	COG0646	methionine synthase
PF996_RS05845	COG2996	Protein conserved in bacteria
PF996_RS05850	COG1744	ABC transporter substrate-binding protein PnrA-like
PF996_RS05855	COG0840	transmembrane signaling receptor activity
PF996_RS05860	COG2124	cytochrome p450
PF996_RS05870	COG1307	EDD domain protein, DegV family
PF996_RS05875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS05895	COG0561	phosphatase activity
PF996_RS05900	COG1073	alpha beta
PF996_RS05905	COG2151	metal-sulfur cluster biosynthetic enzyme
PF996_RS05915	COG0277	FAD linked oxidase domain protein
PF996_RS05920	COG2271	Major facilitator Superfamily
PF996_RS05930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF996_RS05940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF996_RS05945	COG0505	Belongs to the CarA family
PF996_RS05950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF996_RS05955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PF996_RS05970	COG2267	carboxylic ester hydrolase activity
PF996_RS05980	COG1744	ABC transporter substrate-binding protein PnrA-like
PF996_RS05995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF996_RS06000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF996_RS06005	COG5504	Zn-dependent protease
PF996_RS06010	COG0444	Belongs to the ABC transporter superfamily
PF996_RS06015	COG4608	Belongs to the ABC transporter superfamily
PF996_RS06025	COG0601	transmembrane transport
PF996_RS06030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF996_RS06040	COG3328	transposase activity
PF996_RS06045	COG0180	Tryptophanyl-tRNA synthetase
PF996_RS06050	COG4166	transmembrane transport
PF996_RS06055	COG0601	transmembrane transport
PF996_RS06060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF996_RS06065	COG0444	Belongs to the ABC transporter superfamily
PF996_RS06070	COG4608	Belongs to the ABC transporter superfamily
PF996_RS06080	COG0456	acetyltransferase
PF996_RS06085	COG1393	Belongs to the ArsC family
PF996_RS06090	COG0861	Integral membrane protein TerC family
PF996_RS06095	COG4862	establishment of competence for transformation
PF996_RS06100	COG4469	Competence protein
PF996_RS06105	COG1164	Oligoendopeptidase f
PF996_RS06115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF996_RS06120	COG2346	COG2346, Truncated hemoglobins
PF996_RS06125	COG0741	lytic transglycosylase activity
PF996_RS06130	COG4116	CYTH
PF996_RS06140	COG2357	RelA SpoT domain protein
PF996_RS06145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF996_RS06150	COG0564	pseudouridine synthase activity
PF996_RS06160	COG0475	glutathione-regulated potassium exporter activity
PF996_RS06160	COG0569	domain protein
PF996_RS06165	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF996_RS06170	COG0352	thiamine-phosphate diphosphorylase activity
PF996_RS06175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF996_RS06180	COG2104	thiamine diphosphate biosynthetic process
PF996_RS06190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF996_RS06195	COG0351	phosphomethylpyrimidine kinase
PF996_RS06200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PF996_RS06255	COG0210	DNA helicase
PF996_RS06275	COG1131	(ABC) transporter
PF996_RS06285	COG2153	protein acetylation
PF996_RS06295	COG2382	esterase
PF996_RS06300	COG0626	cystathionine gamma-synthase activity
PF996_RS06305	COG0626	cystathionine gamma-synthase activity
PF996_RS06315	COG0582	viral genome integration into host DNA
PF996_RS06320	COG3328	transposase activity
PF996_RS06440	COG3328	transposase activity
PF996_RS06460	COG5444	nuclease activity
PF996_RS06475	COG0135	phosphoribosylanthranilate isomerase activity
PF996_RS06490	COG2367	Beta-lactamase
PF996_RS06495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF996_RS06500	COG0477	Major facilitator Superfamily
PF996_RS06505	COG1846	Transcriptional regulator
PF996_RS06515	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PF996_RS06520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF996_RS06525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PF996_RS06530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS06530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS06535	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF996_RS06565	COG1285	pathogenesis
PF996_RS06575	COG2205	protein histidine kinase activity
PF996_RS06585	COG3383	formate dehydrogenase (NAD+) activity
PF996_RS06590	COG2427	Protein of unknown function (DUF1641)
PF996_RS06595	COG2124	cytochrome p450
PF996_RS06600	COG1819	glycosyl
PF996_RS06610	COG1587	Uroporphyrinogen-III synthase
PF996_RS06615	COG0390	transport system, permease component
PF996_RS06620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF996_RS06625	COG0697	spore germination
PF996_RS06630	COG4297	protein containing double-stranded beta helix domain
PF996_RS06640	COG1252	NADH dehydrogenase
PF996_RS06655	COG1609	Transcriptional regulator
PF996_RS06660	COG0246	Mannitol dehydrogenase
PF996_RS06665	COG2721	sulfolactate sulfo-lyase activity
PF996_RS06670	COG0730	response to heat
PF996_RS06675	COG2318	DinB family
PF996_RS06680	COG0457	Tetratricopeptide repeat
PF996_RS06690	COG1388	LysM domain
PF996_RS06690	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS06690	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF996_RS06700	COG4195	phage-related replication protein
PF996_RS06705	COG2856	Zn peptidase
PF996_RS06710	COG1396	sequence-specific DNA binding
PF996_RS06720	COG1522	sequence-specific DNA binding
PF996_RS06725	COG1484	DNA-dependent DNA replication
PF996_RS06745	COG1595	DNA-templated transcription, initiation
PF996_RS06785	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS06785	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF996_RS06805	COG0306	phosphate transporter
PF996_RS06810	COG1392	Phosphate transport regulator
PF996_RS06815	COG0531	amino acid
PF996_RS06820	COG0346	lactoylglutathione lyase activity
PF996_RS06825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF996_RS06830	COG0463	Glycosyl transferase, family 2
PF996_RS06840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF996_RS06845	COG0477	Major facilitator Superfamily
PF996_RS06850	COG2362	D-Aminopeptidase
PF996_RS06855	COG0601	transmembrane transport
PF996_RS06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF996_RS06865	COG0444	Belongs to the ABC transporter superfamily
PF996_RS06870	COG4166	transmembrane transport
PF996_RS06875	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF996_RS06880	COG4948	Mandelate Racemase Muconate Lactonizing
PF996_RS06885	COG0791	NLP P60 protein
PF996_RS06890	COG4608	Belongs to the ABC transporter superfamily
PF996_RS06895	COG2706	6-phosphogluconolactonase activity
PF996_RS06900	COG1834	amidinotransferase
PF996_RS06905	COG1607	acyl-coa hydrolase
PF996_RS06910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF996_RS06915	COG2076	Multidrug Resistance protein
PF996_RS06920	COG2076	Multidrug Resistance protein
PF996_RS06925	COG0788	formyltetrahydrofolate deformylase activity
PF996_RS06930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF996_RS06940	COG1764	response to oxidative stress
PF996_RS06945	COG1846	Transcriptional regulator
PF996_RS06950	COG1764	response to oxidative stress
PF996_RS06965	COG0463	Glycosyl transferase, family 2
PF996_RS06965	COG0457	Tetratricopeptide repeat
PF996_RS06975	COG2814	Major facilitator Superfamily
PF996_RS06980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF996_RS06990	COG1404	Belongs to the peptidase S8 family
PF996_RS06995	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS07000	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF996_RS07005	COG1122	ATPase activity
PF996_RS07010	COG4721	ABC-type cobalt transport system, permease component
PF996_RS07015	COG1388	LysM domain
PF996_RS07015	COG3858	chitin binding
PF996_RS07025	COG2239	Acts as a magnesium transporter
PF996_RS07030	COG0789	Transcriptional regulator
PF996_RS07045	COG1846	Transcriptional regulator
PF996_RS07050	COG0726	polysaccharide deacetylase
PF996_RS07055	COG1793	dna ligase
PF996_RS07055	COG3285	dna ligase
PF996_RS07060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PF996_RS07065	COG0586	Pfam SNARE associated Golgi protein
PF996_RS07075	COG1191	sigma factor activity
PF996_RS07100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF996_RS07105	COG2323	membrane
PF996_RS07115	COG3594	Acyltransferase
PF996_RS07120	COG5002	protein histidine kinase activity
PF996_RS07125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF996_RS07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF996_RS07150	COG0436	Aminotransferase
PF996_RS07180	COG3852	Histidine kinase
PF996_RS07185	COG1846	Transcriptional regulator
PF996_RS07190	COG1360	Flagellar Motor Protein
PF996_RS07195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF996_RS07200	COG0542	response to heat
PF996_RS07205	COG3949	Membrane
PF996_RS07220	COG0720	synthase
PF996_RS07225	COG0602	queuosine metabolic process
PF996_RS07230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PF996_RS07240	COG4873	Protein conserved in bacteria
PF996_RS07250	COG3773	Cell wall hydrolase
PF996_RS07255	COG2244	polysaccharide biosynthetic process
PF996_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS07265	COG2217	Heavy metal translocating P-type atpase
PF996_RS07270	COG0006	proline dipeptidase activity
PF996_RS07280	COG1609	Transcriptional regulator
PF996_RS07285	COG3711	transcriptional antiterminator
PF996_RS07290	COG1263	PTS System
PF996_RS07290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS07290	COG2190	(PTS) system
PF996_RS07295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS07300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF996_RS07310	COG1533	DNA photolyase activity
PF996_RS07315	COG0840	transmembrane signaling receptor activity
PF996_RS07320	COG2084	Dehydrogenase
PF996_RS07325	COG2340	Cysteine-rich secretory protein family
PF996_RS07330	COG0768	penicillin binding
PF996_RS07335	COG4191	Histidine kinase
PF996_RS07340	COG0436	Aminotransferase
PF996_RS07350	COG0784	Response regulator, receiver
PF996_RS07350	COG0835	chemotaxis
PF996_RS07360	COG2814	Major facilitator Superfamily
PF996_RS07365	COG1376	ErfK ybiS ycfS ynhG family protein
PF996_RS07370	COG1408	metallophosphoesterase
PF996_RS07375	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS07385	COG2200	EAL domain
PF996_RS07390	COG4703	Protein of unknown function (DUF1797)
PF996_RS07395	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
PF996_RS07405	COG0517	IMP dehydrogenase activity
PF996_RS07410	COG0583	DNA-binding transcription factor activity
PF996_RS07415	COG0716	FMN binding
PF996_RS07425	COG0716	FMN binding
PF996_RS07445	COG0668	transmembrane transport
PF996_RS07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS07470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF996_RS07475	COG0303	'Molybdopterin
PF996_RS07480	COG1763	Mo-molybdopterin cofactor biosynthetic process
PF996_RS07485	COG0314	molybdopterin synthase activity
PF996_RS07490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PF996_RS07500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF996_RS07505	COG1136	(ABC) transporter
PF996_RS07510	COG0577	efflux transmembrane transporter activity
PF996_RS07515	COG1349	DNA-binding transcription factor activity
PF996_RS07520	COG1105	Belongs to the carbohydrate kinase PfkB family
PF996_RS07525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS07525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF996_RS07525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF996_RS07530	COG0681	Belongs to the peptidase S26 family
PF996_RS07540	COG0488	(ABC) transporter
PF996_RS07545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF996_RS07550	COG2309	aminopeptidase activity
PF996_RS07560	COG1077	Cell shape determining protein MreB Mrl
PF996_RS07565	COG2002	toxin-antitoxin pair type II binding
PF996_RS07570	COG3852	Histidine kinase
PF996_RS07575	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
PF996_RS07575	COG2105	PFAM AIG2 family protein
PF996_RS07580	COG0569	domain protein
PF996_RS07590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF996_RS07600	COG0561	phosphatase activity
PF996_RS07605	COG0242	peptide deformylase activity
PF996_RS07615	COG0497	DNA recombination
PF996_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS07625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS07625	COG4221	oxidoreductase activity
PF996_RS07625	COG3321	synthase
PF996_RS07630	COG4221	oxidoreductase activity
PF996_RS07630	COG3321	synthase
PF996_RS07630	COG0300	oxidoreductase activity
PF996_RS07630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS07635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS07635	COG4221	oxidoreductase activity
PF996_RS07635	COG3321	synthase
PF996_RS07640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS07640	COG0300	oxidoreductase activity
PF996_RS07640	COG3321	synthase
PF996_RS07640	COG4221	oxidoreductase activity
PF996_RS07650	COG3321	synthase
PF996_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS07650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS07650	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS07650	COG0300	oxidoreductase activity
PF996_RS07655	COG4221	oxidoreductase activity
PF996_RS07655	COG3321	synthase
PF996_RS07655	COG0300	oxidoreductase activity
PF996_RS07655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS07660	COG3321	synthase
PF996_RS07660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS07660	COG4221	oxidoreductase activity
PF996_RS07660	COG0300	oxidoreductase activity
PF996_RS07665	COG4221	oxidoreductase activity
PF996_RS07665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS07665	COG3321	synthase
PF996_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS07670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF996_RS07675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF996_RS07680	COG0022	dehydrogenase e1 component
PF996_RS07685	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF996_RS07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF996_RS07695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS07710	COG1982	Orn Lys Arg decarboxylase major
PF996_RS07730	COG0483	inositol monophosphate 1-phosphatase activity
PF996_RS07740	COG3227	Zinc metalloprotease (Elastase)
PF996_RS07755	COG1595	DNA-templated transcription, initiation
PF996_RS07775	COG1217	gtp-binding protein TYPA
PF996_RS07785	COG4896	Protein conserved in bacteria
PF996_RS07795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PF996_RS07800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF996_RS07805	COG2066	Belongs to the glutaminase family
PF996_RS07815	COG0772	Belongs to the SEDS family
PF996_RS07820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PF996_RS07835	COG2010	Cytochrome c
PF996_RS07835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF996_RS07840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF996_RS07845	COG1845	cytochrome c oxidase, subunit III
PF996_RS07850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF996_RS07855	COG3336	cytochrome c oxidase
PF996_RS07865	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PF996_RS07870	COG2340	Cysteine-rich secretory protein family
PF996_RS07885	COG3679	Belongs to the UPF0342 family
PF996_RS07895	COG0742	ribosomal rna small subunit methyltransferase
PF996_RS07905	COG3314	Sporulation integral membrane protein YlbJ
PF996_RS07910	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF996_RS07915	COG3480	Lon protease (S16) C-terminal proteolytic domain
PF996_RS07925	COG1399	metal-binding, possibly nucleic acid-binding protein
PF996_RS07945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF996_RS07965	COG4839	cell division protein FtsL
PF996_RS07970	COG0768	penicillin binding
PF996_RS07975	COG0768	penicillin binding
PF996_RS07995	COG0772	Belongs to the SEDS family
PF996_RS08010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF996_RS08015	COG0849	cell division
PF996_RS08020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF996_RS08025	COG1404	Belongs to the peptidase S8 family
PF996_RS08025	COG4412	M6 family metalloprotease domain protein
PF996_RS08035	COG1191	sigma factor activity
PF996_RS08040	COG1191	sigma factor activity
PF996_RS08045	COG1119	ATPase activity
PF996_RS08050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF996_RS08055	COG1873	PFAM PRC-barrel domain
PF996_RS08060	COG1496	oxidoreductase activity
PF996_RS08065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PF996_RS08075	COG0762	integral membrane protein
PF996_RS08080	COG2302	S4 RNA-binding domain
PF996_RS08085	COG3599	regulation of cell shape
PF996_RS08090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF996_RS08095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF996_RS08105	COG0564	pseudouridine synthase activity
PF996_RS08115	COG2233	PERMEase
PF996_RS08125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF996_RS08130	COG0505	Belongs to the CarA family
PF996_RS08135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF996_RS08150	COG0284	orotidine-5'-phosphate decarboxylase activity
PF996_RS08155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PF996_RS08165	COG0306	phosphate transporter
PF996_RS08180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF996_RS08185	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
PF996_RS08190	COG1648	precorrin-2 dehydrogenase activity
PF996_RS08205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF996_RS08210	COG1561	YicC-like family, N-terminal region
PF996_RS08220	COG0194	GDP metabolic process
PF996_RS08230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF996_RS08235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF996_RS08240	COG0242	peptide deformylase activity
PF996_RS08250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF996_RS08250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PF996_RS08260	COG0631	protein serine/threonine phosphatase activity
PF996_RS08265	COG2815	serine threonine protein kinase
PF996_RS08265	COG0515	serine threonine protein kinase
PF996_RS08275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF996_RS08280	COG1564	THIamine pyrophosphokinase
PF996_RS08295	COG1302	Protein conserved in bacteria
PF996_RS08300	COG1461	Dihydroxyacetone kinase
PF996_RS08305	COG1760	l-serine dehydratase
PF996_RS08310	COG1760	l-serine dehydratase
PF996_RS08315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF996_RS08330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF996_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS08350	COG1196	nuclear chromosome segregation
PF996_RS08355	COG0552	protein localization to endoplasmic reticulum
PF996_RS08370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF996_RS08380	COG1837	Belongs to the UPF0109 family
PF996_RS08405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF996_RS08420	COG2257	FlhB HrpN YscU SpaS Family
PF996_RS08430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PF996_RS08435	COG0758	DNA mediated transformation
PF996_RS08440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF996_RS08450	COG4974	Belongs to the 'phage' integrase family
PF996_RS08470	COG1815	bacterial-type flagellum-dependent cell motility
PF996_RS08475	COG1558	bacterial-type flagellum-dependent cell motility
PF996_RS08480	COG1677	Flagellar hook-basal body complex protein FliE
PF996_RS08485	COG1766	The M ring may be actively involved in energy transduction
PF996_RS08490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF996_RS08495	COG1317	bacterial-type flagellum organization
PF996_RS08500	COG1157	protein secretion by the type III secretion system
PF996_RS08505	COG2882	bacterial-type flagellum organization
PF996_RS08510	COG3334	PFAM MgtE intracellular
PF996_RS08515	COG3144	bacterial-type flagellum assembly
PF996_RS08520	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PF996_RS08525	COG4786	Flagellar basal body rod
PF996_RS08530	COG1582	Flagellar protein (FlbD)
PF996_RS08535	COG1580	Controls the rotational direction of flagella during chemotaxis
PF996_RS08540	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF996_RS08545	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF996_RS08545	COG1776	CheC inhibitor of MCP methylation
PF996_RS08550	COG2201	protein-glutamate methylesterase activity
PF996_RS08555	COG3190	flagellar
PF996_RS08560	COG1338	Plays a role in the flagellum-specific transport system
PF996_RS08565	COG1987	bacterial-type flagellum assembly
PF996_RS08570	COG1684	flagellar biosynthetic protein fliR
PF996_RS08575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF996_RS08580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF996_RS08585	COG1419	protein localization to endoplasmic reticulum
PF996_RS08590	COG0455	bacterial-type flagellum organization
PF996_RS08595	COG2201	protein-glutamate methylesterase activity
PF996_RS08600	COG2198	Histidine kinase
PF996_RS08600	COG0643	Histidine kinase
PF996_RS08605	COG0835	chemotaxis
PF996_RS08610	COG1776	CheC inhibitor of MCP methylation
PF996_RS08620	COG1191	sigma factor activity
PF996_RS08650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF996_RS08655	COG4589	Belongs to the CDS family
PF996_RS08665	COG0750	zinc metalloprotease
PF996_RS08685	COG0195	Participates in both transcription termination and antitermination
PF996_RS08690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
PF996_RS08695	COG1358	cellular component organization or biogenesis
PF996_RS08705	COG1550	Protein conserved in bacteria
PF996_RS08720	COG0196	riboflavin kinase activity
PF996_RS08735	COG0726	polysaccharide deacetylase
PF996_RS08740	COG0612	Peptidase, M16
PF996_RS08745	COG1873	PFAM PRC-barrel domain
PF996_RS08750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF996_RS08760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF996_RS08765	COG1525	nuclease
PF996_RS08770	COG5444	nuclease activity
PF996_RS08795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF996_RS08805	COG0457	Tetratricopeptide repeat
PF996_RS08825	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF996_RS08825	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS08830	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS08840	COG2433	Pfam Transposase IS66
PF996_RS08850	COG0739	heme binding
PF996_RS08850	COG0741	lytic transglycosylase activity
PF996_RS08850	COG1196	nuclear chromosome segregation
PF996_RS08865	COG0582	viral genome integration into host DNA
PF996_RS09005	COG0776	regulation of translation
PF996_RS09080	COG0210	DNA helicase
PF996_RS09090	COG3655	Transcriptional regulator
PF996_RS09130	COG3328	transposase activity
PF996_RS09215	COG3655	Transcriptional regulator
PF996_RS09340	COG1793	dna ligase
PF996_RS09345	COG2135	peptidase activity
PF996_RS09370	COG4195	phage-related replication protein
PF996_RS09375	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS09375	COG3420	alginic acid biosynthetic process
PF996_RS09430	COG3584	3D domain protein
PF996_RS09445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF996_RS09545	COG1780	Probably involved in ribonucleotide reductase function
PF996_RS09575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS09585	COG0756	dUTP diphosphatase activity
PF996_RS09610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF996_RS09665	COG3331	DNA recombination
PF996_RS09680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PF996_RS09685	COG0527	aspartate kinase activity
PF996_RS09695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF996_RS09700	COG0740	serine-type endopeptidase activity
PF996_RS09710	COG4980	gas vesicle protein
PF996_RS09710	COG1674	ftsk spoiiie
PF996_RS09715	COG2188	Transcriptional regulator
PF996_RS09720	COG2814	Major facilitator Superfamily
PF996_RS09725	COG1846	Transcriptional regulator
PF996_RS09730	COG1033	growth of symbiont in host cell
PF996_RS09730	COG2409	Drug exporters of the RND superfamily
PF996_RS09735	COG0612	Peptidase, M16
PF996_RS09740	COG0612	Peptidase, M16
PF996_RS09745	COG0300	oxidoreductase activity
PF996_RS09760	COG1426	Protein conserved in bacteria
PF996_RS09765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF996_RS09780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF996_RS09790	COG1692	metallophosphoesterase
PF996_RS09795	COG2359	stage V sporulation protein S
PF996_RS09815	COG4550	Control of competence regulator ComK, YlbF/YmcA
PF996_RS09835	COG0582	viral genome integration into host DNA
PF996_RS09840	COG0582	viral genome integration into host DNA
PF996_RS09880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS09885	COG3425	synthase
PF996_RS09890	COG1024	Enoyl-CoA hydratase
PF996_RS09895	COG1024	Enoyl-CoA hydratase
PF996_RS09905	COG3321	synthase
PF996_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS09905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS09905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS09905	COG3321	synthase
PF996_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS09910	COG4221	oxidoreductase activity
PF996_RS09910	COG3321	synthase
PF996_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS09910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS09915	COG3321	synthase
PF996_RS09915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF996_RS09915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF996_RS09915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS09920	COG2124	cytochrome p450
PF996_RS09925	COG3209	COG3209 Rhs family protein
PF996_RS09930	COG3619	membrane
PF996_RS09940	COG1404	Belongs to the peptidase S8 family
PF996_RS09950	COG4195	phage-related replication protein
PF996_RS09955	COG1764	response to oxidative stress
PF996_RS09965	COG2076	Multidrug Resistance protein
PF996_RS10005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF996_RS10010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF996_RS10015	COG4112	unkown
PF996_RS10020	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS10025	COG0464	growth
PF996_RS10030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF996_RS10035	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PF996_RS10040	COG0789	Transcriptional regulator
PF996_RS10045	COG0174	glutamine synthetase
PF996_RS10055	COG2211	Major facilitator Superfamily
PF996_RS10060	COG3507	Belongs to the glycosyl hydrolase 43 family
PF996_RS10075	COG1070	Carbohydrate kinase
PF996_RS10080	COG3848	Pyruvate phosphate dikinase
PF996_RS10080	COG0574	Belongs to the PEP-utilizing enzyme family
PF996_RS10105	COG2378	regulation of single-species biofilm formation
PF996_RS10110	COG2318	DinB family
PF996_RS10115	COG1064	alcohol dehydrogenase
PF996_RS10145	COG5444	nuclease activity
PF996_RS10205	COG3397	chitin binding
PF996_RS10225	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS10230	COG0756	dUTP diphosphatase activity
PF996_RS10235	COG4195	phage-related replication protein
PF996_RS10270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF996_RS10280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF996_RS10300	COG0785	Cytochrome C biogenesis protein
PF996_RS10305	COG2201	protein-glutamate methylesterase activity
PF996_RS10310	COG4846	Membrane protein involved in cytochrome C biogenesis
PF996_RS10320	COG0071	Belongs to the small heat shock protein (HSP20) family
PF996_RS10335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF996_RS10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS10360	COG0824	Thioesterase
PF996_RS10370	COG4841	protein insertion into membrane
PF996_RS10380	COG1832	CoA-binding protein
PF996_RS10385	COG0187	DNA topoisomerase II activity
PF996_RS10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF996_RS10405	COG1115	amino acid carrier protein
PF996_RS10415	COG1063	alcohol dehydrogenase
PF996_RS10420	COG0800	Aldolase
PF996_RS10425	COG1312	Catalyzes the dehydration of D-mannonate
PF996_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS10435	COG1609	Transcriptional regulator
PF996_RS10440	COG2271	Major facilitator Superfamily
PF996_RS10485	COG2205	protein histidine kinase activity
PF996_RS10490	COG0745	RESPONSE REGULATOR receiver
PF996_RS10500	COG3507	Belongs to the glycosyl hydrolase 43 family
PF996_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS10530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF996_RS10535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF996_RS10540	COG2610	gluconate transmembrane transporter activity
PF996_RS10545	COG2124	cytochrome p450
PF996_RS10565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF996_RS10575	COG2246	polysaccharide biosynthetic process
PF996_RS10580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF996_RS10585	COG0586	Pfam SNARE associated Golgi protein
PF996_RS10590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF996_RS10595	COG1024	Enoyl-CoA hydratase
PF996_RS10600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF996_RS10605	COG0511	ligase activity, forming carbon-carbon bonds
PF996_RS10610	COG0439	Biotin carboxylase
PF996_RS10615	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS10620	COG1960	acyl-CoA dehydrogenase activity
PF996_RS10625	COG1649	PFAM Uncharacterised BCR, COG1649
PF996_RS10635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS10635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF996_RS10645	COG2027	D-alanyl-D-alanine carboxypeptidase
PF996_RS10650	COG2017	converts alpha-aldose to the beta-anomer
PF996_RS10655	COG0534	Mate efflux family protein
PF996_RS10665	COG5444	nuclease activity
PF996_RS10675	COG3328	transposase activity
PF996_RS10690	COG4824	toxin secretion phage lysis holin
PF996_RS10710	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS10715	COG1388	LysM domain
PF996_RS10715	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF996_RS10795	COG1802	Transcriptional regulator
PF996_RS10795	COG4626	Terminase
PF996_RS10825	COG0582	viral genome integration into host DNA
PF996_RS10830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF996_RS10990	COG0582	viral genome integration into host DNA
PF996_RS10995	COG0166	Belongs to the GPI family
PF996_RS11000	COG0405	Gamma-glutamyltransferase
PF996_RS11005	COG2814	Major facilitator Superfamily
PF996_RS11010	COG0640	Transcriptional regulator
PF996_RS11015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF996_RS11025	COG0604	alcohol dehydrogenase
PF996_RS11035	COG0493	'glutamate synthase
PF996_RS11040	COG0067	glutamate synthase
PF996_RS11040	COG0069	glutamate synthase activity
PF996_RS11040	COG0070	glutamate synthase
PF996_RS11045	COG0583	DNA-binding transcription factor activity
PF996_RS11050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF996_RS11065	COG0300	oxidoreductase activity
PF996_RS11070	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF996_RS11080	COG2814	Major facilitator Superfamily
PF996_RS11085	COG1070	Carbohydrate kinase
PF996_RS11090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF996_RS11095	COG0243	molybdopterin cofactor binding
PF996_RS11115	COG3328	transposase activity
PF996_RS11130	COG5444	nuclease activity
PF996_RS11135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF996_RS11140	COG0662	Cupin 2, conserved barrel domain protein
PF996_RS11140	COG2207	Transcriptional regulator
PF996_RS11145	COG1309	transcriptional regulator
PF996_RS11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS11160	COG0640	Transcriptional regulator
PF996_RS11165	COG0741	lytic transglycosylase activity
PF996_RS11170	COG2322	membrane
PF996_RS11185	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF996_RS11195	COG1388	LysM domain
PF996_RS11195	COG3584	3D domain protein
PF996_RS11200	COG0514	ATP-dependent DNA helicase (RecQ)
PF996_RS11210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF996_RS11215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF996_RS11230	COG0071	Belongs to the small heat shock protein (HSP20) family
PF996_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS11270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF996_RS11275	COG0733	neurotransmitter:sodium symporter activity
PF996_RS11280	COG0385	Bile acid
PF996_RS11285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS11290	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF996_RS11300	COG4548	von Willebrand factor, type A
PF996_RS11305	COG0714	Associated with various cellular activities
PF996_RS11310	COG2032	superoxide dismutase activity
PF996_RS11315	COG0791	NLP P60 protein
PF996_RS11315	COG1388	LysM domain
PF996_RS11320	COG1819	glycosyl
PF996_RS11325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF996_RS11330	COG0534	Mate efflux family protein
PF996_RS11335	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS11340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF996_RS11345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF996_RS11355	COG2962	Rard protein
PF996_RS11370	COG1942	4-Oxalocrotonate Tautomerase
PF996_RS11380	COG1733	regulation of RNA biosynthetic process
PF996_RS11385	COG0778	Nitroreductase
PF996_RS11390	COG0400	carboxylic ester hydrolase activity
PF996_RS11395	COG0346	lactoylglutathione lyase activity
PF996_RS11405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF996_RS11420	COG2188	Transcriptional regulator
PF996_RS11425	COG0793	Belongs to the peptidase S41A family
PF996_RS11425	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS11430	COG2226	methyltransferase
PF996_RS11440	COG1876	peptidase activity
PF996_RS11460	COG0671	phosphoesterase, PA-phosphatase related
PF996_RS11490	COG1509	lysine 2,3-aminomutase activity
PF996_RS11495	COG0456	acetyltransferase
PF996_RS11500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF996_RS11505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF996_RS11510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF996_RS11515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF996_RS11520	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF996_RS11530	COG0456	acetyltransferase
PF996_RS11535	COG0463	Glycosyl transferase, family 2
PF996_RS11550	COG4641	Protein conserved in bacteria
PF996_RS11560	COG1086	Polysaccharide biosynthesis protein
PF996_RS11580	COG1388	LysM domain
PF996_RS11585	COG0457	Tetratricopeptide repeat
PF996_RS11590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF996_RS11610	COG3391	amine dehydrogenase activity
PF996_RS11615	COG3328	transposase activity
PF996_RS11645	COG5444	nuclease activity
PF996_RS11650	COG4282	regulation of fungal-type cell wall biogenesis
PF996_RS11655	COG1525	nuclease
PF996_RS11685	COG1846	Transcriptional regulator
PF996_RS11690	COG4698	Protein conserved in bacteria
PF996_RS11695	COG2755	lipolytic protein G-D-S-L family
PF996_RS11700	COG1999	signal sequence binding
PF996_RS11710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF996_RS11715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF996_RS11720	COG1272	protein, Hemolysin III
PF996_RS11725	COG0204	Acyl-transferase
PF996_RS11730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF996_RS11745	COG2521	methyltransferase
PF996_RS11745	COG2136	Putative SAM-dependent methyltransferase
PF996_RS11760	COG1413	lyase activity
PF996_RS11765	COG1418	mRNA catabolic process
PF996_RS11770	COG0386	Belongs to the glutathione peroxidase family
PF996_RS11780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF996_RS11790	COG1278	Cold shock
PF996_RS11810	COG0328	RNA-DNA hybrid ribonuclease activity
PF996_RS11815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PF996_RS11820	COG0328	RNA-DNA hybrid ribonuclease activity
PF996_RS11830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF996_RS11845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF996_RS11855	COG1755	Isoprenylcysteine carboxyl methyltransferase
PF996_RS11860	COG3424	synthase
PF996_RS11880	COG1335	isochorismatase
PF996_RS11885	COG2233	PERMEase
PF996_RS11895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PF996_RS11900	COG1199	ATP-dependent helicase activity
PF996_RS11915	COG0116	Belongs to the methyltransferase superfamily
PF996_RS11945	COG3359	exonuclease
PF996_RS11950	COG1111	helicase
PF996_RS11950	COG1205	dead DEAH box helicase
PF996_RS11955	COG2190	(PTS) system
PF996_RS11960	COG0071	Belongs to the small heat shock protein (HSP20) family
PF996_RS12000	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF996_RS12000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF996_RS12010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF996_RS12015	COG3935	DnaD domain protein
PF996_RS12025	COG0436	Aminotransferase
PF996_RS12030	COG5353	protein conserved in bacteria
PF996_RS12040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF996_RS12040	COG1199	ATP-dependent helicase activity
PF996_RS12070	COG0438	transferase activity, transferring glycosyl groups
PF996_RS12075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF996_RS12090	COG1694	Mazg nucleotide pyrophosphohydrolase
PF996_RS12095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS12100	COG2140	Oxalate decarboxylase
PF996_RS12110	COG4347	Protein of unknown function (DUF1405)
PF996_RS12115	COG2010	Cytochrome c
PF996_RS12115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF996_RS12120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF996_RS12125	COG0723	plastoquinol--plastocyanin reductase activity
PF996_RS12140	COG0457	Tetratricopeptide repeat
PF996_RS12150	COG0287	Prephenate dehydrogenase
PF996_RS12185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF996_RS12190	COG4401	Chorismate mutase type I
PF996_RS12205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF996_RS12210	COG0105	UTP biosynthetic process
PF996_RS12215	COG0142	geranyltranstransferase activity
PF996_RS12225	COG0142	geranyltranstransferase activity
PF996_RS12240	COG0776	regulation of translation
PF996_RS12245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF996_RS12285	COG0539	negative regulation of cytoplasmic translation
PF996_RS12300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PF996_RS12305	COG2959	enzyme of heme biosynthesis
PF996_RS12310	COG3773	Cell wall hydrolase
PF996_RS12310	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS12315	COG2339	peptidase activity
PF996_RS12320	COG0492	ferredoxin-NADP+ reductase activity
PF996_RS12325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF996_RS12330	COG4862	establishment of competence for transformation
PF996_RS12335	COG1408	metallophosphoesterase
PF996_RS12345	COG1388	LysM domain
PF996_RS12350	COG1266	CAAX protease self-immunity
PF996_RS12355	COG0514	ATP-dependent DNA helicase (RecQ)
PF996_RS12360	COG4955	Helix-turn-helix domain
PF996_RS12365	COG1141	Ferredoxin
PF996_RS12370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PF996_RS12375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF996_RS12385	COG1595	DNA-templated transcription, initiation
PF996_RS12390	COG5002	protein histidine kinase activity
PF996_RS12395	COG0745	RESPONSE REGULATOR receiver
PF996_RS12400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF996_RS12405	COG1333	cytochrome c biogenesis protein
PF996_RS12410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS12415	COG1187	pseudouridine synthase activity
PF996_RS12420	COG0700	Nucleoside recognition
PF996_RS12425	COG2715	membrane protein required for spore maturation
PF996_RS12430	COG1686	Belongs to the peptidase S11 family
PF996_RS12455	COG1547	Domain of unknown function (DUF309)
PF996_RS12460	COG0456	acetyltransferase
PF996_RS12475	COG0307	riboflavin synthase, alpha
PF996_RS12480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF996_RS12480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF996_RS12490	COG0681	Belongs to the peptidase S26 family
PF996_RS12500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF996_RS12505	COG4086	secreted protein
PF996_RS12510	COG0019	diaminopimelate decarboxylase activity
PF996_RS12515	COG0697	spore germination
PF996_RS12530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF996_RS12550	COG1191	sigma factor activity
PF996_RS12560	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS12565	COG1686	Belongs to the peptidase S11 family
PF996_RS12570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PF996_RS12575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PF996_RS12580	COG4974	Belongs to the 'phage' integrase family
PF996_RS12590	COG0735	belongs to the Fur family
PF996_RS12595	COG1300	Membrane
PF996_RS12610	COG0281	malic enzyme
PF996_RS12615	COG1757	Na H antiporter
PF996_RS12620	COG1027	Aspartate ammonia-lyase
PF996_RS12625	COG0252	asparaginase activity
PF996_RS12630	COG1396	sequence-specific DNA binding
PF996_RS12635	COG1379	DNA repair
PF996_RS12640	COG0494	nUDIX hydrolase
PF996_RS12650	COG0667	Aldo Keto reductase
PF996_RS12660	COG1073	alpha beta
PF996_RS12670	COG4918	Iron-sulphur cluster biosynthesis
PF996_RS12675	COG0456	acetyltransferase
PF996_RS12675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF996_RS12680	COG2329	Antibiotic biosynthesis monooxygenase
PF996_RS12685	COG0456	acetyltransferase
PF996_RS12690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF996_RS12705	COG0628	permease
PF996_RS12715	COG0346	lactoylglutathione lyase activity
PF996_RS12725	COG3048	D-serine ammonia-lyase activity
PF996_RS12730	COG0300	oxidoreductase activity
PF996_RS12735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS12740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF996_RS12745	COG1024	Enoyl-CoA hydratase
PF996_RS12750	COG3425	synthase
PF996_RS12755	COG2124	cytochrome p450
PF996_RS12765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS12765	COG3321	synthase
PF996_RS12765	COG4221	oxidoreductase activity
PF996_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS12770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS12770	COG3321	synthase
PF996_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12770	COG3321	synthase
PF996_RS12770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS12770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS12770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS12770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12775	COG0300	oxidoreductase activity
PF996_RS12775	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS12775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS12775	COG3321	synthase
PF996_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF996_RS12780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF996_RS12780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12780	COG3321	synthase
PF996_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS12790	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS12805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF996_RS12805	COG2070	2-Nitropropane dioxygenase
PF996_RS12835	COG0596	Alpha beta hydrolase
PF996_RS12850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PF996_RS12855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF996_RS12870	COG0706	membrane insertase activity
PF996_RS12875	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF996_RS12880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF996_RS12885	COG0346	lactoylglutathione lyase activity
PF996_RS12895	COG1376	ErfK ybiS ycfS ynhG family protein
PF996_RS12900	COG4129	membrane
PF996_RS12905	COG1126	abc transporter atp-binding protein
PF996_RS12910	COG0765	amino acid transport
PF996_RS12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS12925	COG1597	lipid kinase activity
PF996_RS12930	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF996_RS12935	COG0022	dehydrogenase e1 component
PF996_RS12940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF996_RS12945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF996_RS12950	COG3426	butyrate kinase activity
PF996_RS12955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF996_RS12960	COG0280	phosphate acetyltransferase
PF996_RS12965	COG3290	protein histidine kinase activity
PF996_RS12965	COG3829	transcription factor binding
PF996_RS12975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PF996_RS12980	COG2079	MmgE PrpD family protein
PF996_RS12985	COG0372	Belongs to the citrate synthase family
PF996_RS12990	COG1960	acyl-CoA dehydrogenase activity
PF996_RS12995	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF996_RS13000	COG0183	Belongs to the thiolase family
PF996_RS13005	COG0584	glycerophosphoryl diester phosphodiesterase
PF996_RS13010	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS13035	COG1902	pentaerythritol trinitrate reductase activity
PF996_RS13050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF996_RS13055	COG0745	RESPONSE REGULATOR receiver
PF996_RS13060	COG0750	zinc metalloprotease
PF996_RS13065	COG0497	DNA recombination
PF996_RS13075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PF996_RS13085	COG0142	geranyltranstransferase activity
PF996_RS13095	COG1570	exodeoxyribonuclease VII activity
PF996_RS13110	COG1302	Protein conserved in bacteria
PF996_RS13115	COG0439	Biotin carboxylase
PF996_RS13120	COG0511	ligase activity, forming carbon-carbon bonds
PF996_RS13160	COG3854	ATPases associated with a variety of cellular activities
PF996_RS13175	COG0006	proline dipeptidase activity
PF996_RS13185	COG3872	metal-dependent enzyme
PF996_RS13195	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF996_RS13210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF996_RS13230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF996_RS13245	COG1396	sequence-specific DNA binding
PF996_RS13255	COG0681	Belongs to the peptidase S26 family
PF996_RS13280	COG4940	Competence protein ComGF
PF996_RS13290	COG4970	Tfp pilus assembly protein FimT
PF996_RS13295	COG4537	Required for transformation and DNA binding
PF996_RS13300	COG1459	type II secretion system
PF996_RS13305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF996_RS13310	COG0598	Magnesium transport protein CorA
PF996_RS13315	COG1253	flavin adenine dinucleotide binding
PF996_RS13320	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS13330	COG1393	Belongs to the ArsC family
PF996_RS13340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS13350	COG0011	TIGRFAM Protein of
PF996_RS13360	COG2866	Carboxypeptidase
PF996_RS13365	COG1940	carbohydrate kinase activity
PF996_RS13370	COG4483	Protein conserved in bacteria
PF996_RS13375	COG1757	Na H antiporter
PF996_RS13385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF996_RS13400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF996_RS13405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF996_RS13410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF996_RS13415	COG0581	inorganic phosphate transmembrane transporter activity
PF996_RS13420	COG0573	inorganic phosphate transmembrane transporter activity
PF996_RS13425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF996_RS13430	COG0768	penicillin binding
PF996_RS13435	COG0477	Major facilitator Superfamily
PF996_RS13440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF996_RS13445	COG2839	Protein conserved in bacteria
PF996_RS13450	COG5521	maltodextrose utilization protein MalA
PF996_RS13455	COG1388	LysM domain
PF996_RS13465	COG4709	membrane
PF996_RS13470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
PF996_RS13475	COG0735	belongs to the Fur family
PF996_RS13480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS13495	COG0513	Belongs to the DEAD box helicase family
PF996_RS13510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF996_RS13515	COG2384	SAM-dependent methyltransferase
PF996_RS13520	COG2010	Cytochrome c
PF996_RS13525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PF996_RS13530	COG0358	DNA primase activity
PF996_RS13545	COG0517	IMP dehydrogenase activity
PF996_RS13550	COG0751	glycine-tRNA ligase activity
PF996_RS13570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF996_RS13575	COG0295	cytidine deaminase activity
PF996_RS13580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PF996_RS13590	COG1480	7TM receptor with intracellular HD hydrolase
PF996_RS13595	COG1702	phosphate starvation-inducible protein PhoH
PF996_RS13600	COG0561	phosphatase activity
PF996_RS13615	COG4864	UPF0365 protein
PF996_RS13620	COG1030	water channel activity
PF996_RS13625	COG1610	YqeY-like protein
PF996_RS13635	COG1283	sodium-dependent phosphate transmembrane transporter activity
PF996_RS13645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF996_RS13650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF996_RS13680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF996_RS13695	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS13725	COG0658	competence protein
PF996_RS13725	COG2333	competence protein COMEC
PF996_RS13730	COG2131	deaminase
PF996_RS13735	COG1555	photosystem II stabilization
PF996_RS13735	COG1596	polysaccharide export
PF996_RS13740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF996_RS13745	COG2226	methyltransferase
PF996_RS13750	COG0799	negative regulation of ribosome biogenesis
PF996_RS13755	COG1713	HD superfamily hydrolase involved in NAD metabolism
PF996_RS13765	COG1534	Rna-binding protein
PF996_RS13770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF996_RS13775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF996_RS13780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PF996_RS13795	COG2755	lipolytic protein G-D-S-L family
PF996_RS13805	COG0398	Pfam SNARE associated Golgi protein
PF996_RS13835	COG5444	nuclease activity
PF996_RS13840	COG4282	regulation of fungal-type cell wall biogenesis
PF996_RS13860	COG0583	DNA-binding transcription factor activity
PF996_RS13875	COG5002	protein histidine kinase activity
PF996_RS13875	COG0642	Histidine kinase
PF996_RS13880	COG0745	RESPONSE REGULATOR receiver
PF996_RS13885	COG2311	Membrane
PF996_RS13895	COG0454	-acetyltransferase
PF996_RS13900	COG0563	adenylate kinase activity
PF996_RS13910	COG2814	Major facilitator Superfamily
PF996_RS13915	COG0456	acetyltransferase
PF996_RS13920	COG2318	DinB family
PF996_RS13930	COG0561	phosphatase activity
PF996_RS13935	COG0561	phosphatase activity
PF996_RS13945	COG1482	cell wall glycoprotein biosynthetic process
PF996_RS13950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF996_RS13950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF996_RS13950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS13955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS13955	COG3711	transcriptional antiterminator
PF996_RS13965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF996_RS13970	COG0583	DNA-binding transcription factor activity
PF996_RS13975	COG2814	Major facilitator Superfamily
PF996_RS13980	COG2124	cytochrome p450
PF996_RS13980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF996_RS13985	COG1309	transcriptional regulator
PF996_RS13990	COG2226	methyltransferase
PF996_RS14005	COG2116	formate transmembrane transporter activity
PF996_RS14010	COG5609	conserved protein (DUF2294)
PF996_RS14015	COG3383	formate dehydrogenase (NAD+) activity
PF996_RS14020	COG2427	Protein of unknown function (DUF1641)
PF996_RS14035	COG0626	cystathionine gamma-synthase activity
PF996_RS14040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF996_RS14065	COG0768	penicillin binding
PF996_RS14095	COG4824	toxin secretion phage lysis holin
PF996_RS14115	COG5434	Belongs to the glycosyl hydrolase 28 family
PF996_RS14120	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF996_RS14130	COG3953	SLT domain
PF996_RS14130	COG5280	Phage tail tape measure protein TP901
PF996_RS14215	COG0582	viral genome integration into host DNA
PF996_RS14220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF996_RS14340	COG1396	sequence-specific DNA binding
PF996_RS14360	COG0826	peptidase U32
PF996_RS14365	COG0826	peptidase U32
PF996_RS14370	COG4122	O-methyltransferase activity
PF996_RS14375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF996_RS14390	COG4472	Bacterial protein of unknown function (DUF965)
PF996_RS14400	COG0628	permease
PF996_RS14405	COG1126	abc transporter atp-binding protein
PF996_RS14410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS14415	COG0765	amino acid transport
PF996_RS14420	COG0765	amino acid transport
PF996_RS14435	COG3881	PFAM PRC-barrel domain
PF996_RS14440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF996_RS14445	COG0457	Tetratricopeptide repeat
PF996_RS14455	COG1104	cysteine desulfurase activity
PF996_RS14460	COG1959	2 iron, 2 sulfur cluster binding
PF996_RS14465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF996_RS14470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF996_RS14495	COG3103	Sh3 type 3 domain protein
PF996_RS14495	COG4991	sh3 domain protein
PF996_RS14495	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS14505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF996_RS14515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF996_RS14515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PF996_RS14520	COG5416	Lipopolysaccharide assembly protein A domain
PF996_RS14525	COG0490	domain, Protein
PF996_RS14530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF996_RS14530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF996_RS14540	COG2244	polysaccharide biosynthetic process
PF996_RS14545	COG2323	membrane
PF996_RS14555	COG1862	Preprotein translocase
PF996_RS14595	COG1388	LysM domain
PF996_RS14605	COG0157	Belongs to the NadC ModD family
PF996_RS14610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PF996_RS14615	COG1104	cysteine desulfurase activity
PF996_RS14620	COG1827	regulation of RNA biosynthetic process
PF996_RS14625	COG0077	Prephenate dehydratase
PF996_RS14640	COG3290	protein histidine kinase activity
PF996_RS14645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PF996_RS14650	COG2868	ribosomal protein
PF996_RS14660	COG1994	Peptidase M50
PF996_RS14665	COG0739	heme binding
PF996_RS14670	COG2894	cell division
PF996_RS14680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF996_RS14690	COG1077	Cell shape determining protein MreB Mrl
PF996_RS14710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PF996_RS14715	COG0285	dihydrofolate synthase activity
PF996_RS14720	COG0525	valine-tRNA ligase activity
PF996_RS14730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF996_RS14735	COG1388	LysM domain
PF996_RS14745	COG0113	porphobilinogen synthase activity
PF996_RS14750	COG1587	Uroporphyrinogen-III synthase
PF996_RS14760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF996_RS14780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF996_RS14785	COG0470	DNA polymerase III
PF996_RS14785	COG1067	ATP-dependent peptidase activity
PF996_RS14800	COG1477	protein flavinylation
PF996_RS14800	COG0457	Tetratricopeptide repeat
PF996_RS14815	COG0473	3-isopropylmalate dehydrogenase activity
PF996_RS14830	COG0440	acetolactate synthase activity
PF996_RS14835	COG0028	Belongs to the TPP enzyme family
PF996_RS14855	COG0732	type I restriction modification DNA specificity domain
PF996_RS14865	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PF996_RS14890	COG0622	Phosphoesterase
PF996_RS14895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PF996_RS14905	COG5401	PFAM Sporulation and spore germination
PF996_RS14915	COG1846	Transcriptional regulator
PF996_RS14920	COG2197	response regulator
PF996_RS14925	COG0824	Thioesterase
PF996_RS14930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF996_RS14935	COG1053	succinate dehydrogenase
PF996_RS14940	COG2009	succinate dehydrogenase
PF996_RS14945	COG1719	4-vinyl reductase, 4VR
PF996_RS14950	COG0527	aspartate kinase activity
PF996_RS14960	COG3118	belongs to the thioredoxin family
PF996_RS14965	COG3534	alpha-L-arabinofuranosidase
PF996_RS14970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PF996_RS14975	COG2086	electron transfer activity
PF996_RS14980	COG1024	Enoyl-CoA hydratase
PF996_RS14985	COG1309	transcriptional regulator
PF996_RS14990	COG0318	PFAM AMP-dependent synthetase and ligase
PF996_RS15000	COG3766	membrane
PF996_RS15010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF996_RS15010	COG1796	DNA polymerase
PF996_RS15015	COG1286	toxin biosynthetic process
PF996_RS15030	COG0072	phenylalanine-tRNA ligase activity
PF996_RS15030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF996_RS15035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PF996_RS15040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF996_RS15050	COG3835	regulator
PF996_RS15055	COG0277	FAD linked oxidase domain protein
PF996_RS15060	COG0247	lactate metabolic process
PF996_RS15065	COG1966	Carbon starvation protein
PF996_RS15070	COG3534	alpha-L-arabinofuranosidase
PF996_RS15075	COG0395	ABC-type sugar transport system, permease component
PF996_RS15080	COG1175	transmembrane transport
PF996_RS15085	COG1653	transport
PF996_RS15095	COG0647	UMP catabolic process
PF996_RS15100	COG0235	Class ii aldolase
PF996_RS15105	COG1069	ribulokinase activity
PF996_RS15110	COG2160	L-arabinose isomerase activity
PF996_RS15115	COG3507	Belongs to the glycosyl hydrolase 43 family
PF996_RS15120	COG1363	Peptidase, m42
PF996_RS15130	COG3326	Membrane
PF996_RS15145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PF996_RS15150	COG1346	cytolysis
PF996_RS15155	COG1380	Effector of murein hydrolase LrgA
PF996_RS15160	COG3279	Response regulator of the LytR AlgR family
PF996_RS15165	COG3275	phosphorelay sensor kinase activity
PF996_RS15170	COG1011	Hydrolase
PF996_RS15185	COG0398	Pfam SNARE associated Golgi protein
PF996_RS15190	COG1484	DNA-dependent DNA replication
PF996_RS15195	COG3611	Membrane attachment protein
PF996_RS15210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF996_RS15215	COG1733	regulation of RNA biosynthetic process
PF996_RS15220	COG2814	Major facilitator Superfamily
PF996_RS15225	COG0656	L-ascorbic acid biosynthetic process
PF996_RS15230	COG0237	dephospho-CoA kinase activity
PF996_RS15235	COG1971	Probably functions as a manganese efflux pump
PF996_RS15240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PF996_RS15245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF996_RS15245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF996_RS15250	COG5002	protein histidine kinase activity
PF996_RS15255	COG0745	RESPONSE REGULATOR receiver
PF996_RS15265	COG0538	isocitrate dehydrogenase activity
PF996_RS15270	COG0372	Belongs to the citrate synthase family
PF996_RS15280	COG0457	Tetratricopeptide repeat
PF996_RS15285	COG5444	nuclease activity
PF996_RS15320	COG0628	permease
PF996_RS15325	COG3030	protein affecting phage T7 exclusion by the F plasmid
PF996_RS15330	COG0469	pyruvate kinase activity
PF996_RS15350	COG0281	malic enzyme
PF996_RS15355	COG0587	DNA-directed DNA polymerase activity
PF996_RS15375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PF996_RS15385	COG4109	DRTGG domain
PF996_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS15415	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF996_RS15425	COG0827	DNA restriction-modification system
PF996_RS15430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PF996_RS15435	COG3874	Sporulation protein YtfJ
PF996_RS15445	COG1714	RDD family
PF996_RS15450	COG0616	signal peptide processing
PF996_RS15455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF996_RS15460	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PF996_RS15465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF996_RS15480	COG1104	cysteine desulfurase activity
PF996_RS15485	COG1114	Component of the transport system for branched-chain amino acids
PF996_RS15495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF996_RS15500	COG1309	transcriptional regulator
PF996_RS15505	COG1956	GAF domain-containing protein
PF996_RS15510	COG2199	diguanylate cyclase activity
PF996_RS15510	COG2203	Gaf domain
PF996_RS15520	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS15525	COG4282	regulation of fungal-type cell wall biogenesis
PF996_RS15575	COG1017	nitric oxide dioxygenase activity
PF996_RS15575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF996_RS15585	COG0693	protein deglycase activity
PF996_RS15605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF996_RS15610	COG1378	Sugar-specific transcriptional regulator TrmB
PF996_RS15635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF996_RS15640	COG0454	-acetyltransferase
PF996_RS15645	COG0517	IMP dehydrogenase activity
PF996_RS15650	COG0123	including yeast histone deacetylase and acetoin utilization protein
PF996_RS15655	COG1360	Flagellar Motor Protein
PF996_RS15660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF996_RS15665	COG1609	Transcriptional regulator
PF996_RS15670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PF996_RS15670	COG1605	Chorismate mutase
PF996_RS15675	COG3118	belongs to the thioredoxin family
PF996_RS15680	COG4980	gas vesicle protein
PF996_RS15685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF996_RS15695	COG1674	ftsk spoiiie
PF996_RS15700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF996_RS15710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS15720	COG1363	Peptidase, m42
PF996_RS15725	COG5584	Small secreted protein
PF996_RS15730	COG0281	malic enzyme
PF996_RS15735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF996_RS15750	COG0510	thiamine kinase activity
PF996_RS15755	COG1597	lipid kinase activity
PF996_RS15765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF996_RS15770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF996_RS15775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF996_RS15780	COG2252	PERMEase
PF996_RS15785	COG4473	ABC transporter
PF996_RS15790	COG1131	(ABC) transporter
PF996_RS15795	COG1349	DNA-binding transcription factor activity
PF996_RS15800	COG1187	pseudouridine synthase activity
PF996_RS15805	COG2244	polysaccharide biosynthetic process
PF996_RS15810	COG2081	HI0933 family
PF996_RS15815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF996_RS15825	COG1609	Transcriptional regulator
PF996_RS15830	COG1653	transport
PF996_RS15835	COG1175	transmembrane transport
PF996_RS15840	COG0395	ABC-type sugar transport system, permease component
PF996_RS15845	COG1486	melibiose metabolic process
PF996_RS15855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF996_RS15870	COG2202	Pas domain
PF996_RS15870	COG1366	Belongs to the anti-sigma-factor antagonist family
PF996_RS15875	COG2814	Major facilitator Superfamily
PF996_RS15880	COG5522	Integral membrane protein (intg_mem_TP0381)
PF996_RS15885	COG0577	efflux transmembrane transporter activity
PF996_RS15890	COG1136	(ABC) transporter
PF996_RS15895	COG2205	protein histidine kinase activity
PF996_RS15900	COG0745	RESPONSE REGULATOR receiver
PF996_RS15905	COG0577	efflux transmembrane transporter activity
PF996_RS15910	COG1136	(ABC) transporter
PF996_RS15930	COG1131	(ABC) transporter
PF996_RS15935	COG1725	Transcriptional regulator
PF996_RS15950	COG0640	Transcriptional regulator
PF996_RS15955	COG0477	Major facilitator Superfamily
PF996_RS15960	COG1242	4 iron, 4 sulfur cluster binding
PF996_RS15965	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PF996_RS15975	COG0584	glycerophosphoryl diester phosphodiesterase
PF996_RS15985	COG2267	carboxylic ester hydrolase activity
PF996_RS15990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF996_RS15995	COG1113	amino acid transport
PF996_RS16000	COG0367	asparagine synthase
PF996_RS16020	COG1506	peptidase
PF996_RS16025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF996_RS16030	COG1116	anion transmembrane transporter activity
PF996_RS16035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF996_RS16040	COG0494	nUDIX hydrolase
PF996_RS16045	COG4824	toxin secretion phage lysis holin
PF996_RS16050	COG0783	Belongs to the Dps family
PF996_RS16075	COG0288	reversible hydration of carbon dioxide
PF996_RS16085	COG1271	oxidase subunit
PF996_RS16090	COG1294	oxidase, subunit
PF996_RS16100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF996_RS16105	COG1321	iron dependent repressor
PF996_RS16105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF996_RS16110	COG1121	(ABC) transporter
PF996_RS16115	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF996_RS16120	COG4948	Mandelate Racemase Muconate Lactonizing
PF996_RS16130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PF996_RS16135	COG0596	Alpha beta hydrolase
PF996_RS16145	COG1169	isochorismate synthase
PF996_RS16150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF996_RS16155	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PF996_RS16280	COG3859	Proton-coupled thiamine transporter YuaJ
PF996_RS16285	COG2268	Band 7 protein
PF996_RS16290	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF996_RS16295	COG2318	DinB family
PF996_RS16305	COG1454	alcohol dehydrogenase
PF996_RS16310	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS16315	COG1510	regulation of RNA biosynthetic process
PF996_RS16325	COG0569	domain protein
PF996_RS16330	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF996_RS16335	COG1017	nitric oxide dioxygenase activity
PF996_RS16335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF996_RS16355	COG0457	Tetratricopeptide repeat
PF996_RS16390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF996_RS16405	COG0628	permease
PF996_RS16410	COG0673	inositol 2-dehydrogenase activity
PF996_RS16415	COG0693	protein deglycase activity
PF996_RS16420	COG0840	transmembrane signaling receptor activity
PF996_RS16430	COG0840	transmembrane signaling receptor activity
PF996_RS16435	COG0840	transmembrane signaling receptor activity
PF996_RS16450	COG2070	2-Nitropropane dioxygenase
PF996_RS16455	COG0432	Pfam Uncharacterised protein family UPF0047
PF996_RS16460	COG0366	Alpha amylase catalytic
PF996_RS16465	COG1253	flavin adenine dinucleotide binding
PF996_RS16470	COG2738	Putative neutral zinc metallopeptidase
PF996_RS16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF996_RS16510	COG1335	isochorismatase
PF996_RS16515	COG1979	alcohol dehydrogenase
PF996_RS16520	COG1979	alcohol dehydrogenase
PF996_RS16525	COG2155	Conserved Protein
PF996_RS16530	COG1098	S1 RNA binding domain
PF996_RS16535	COG0436	Aminotransferase
PF996_RS16540	COG1522	sequence-specific DNA binding
PF996_RS16545	COG2267	carboxylic ester hydrolase activity
PF996_RS16555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PF996_RS16560	COG2205	protein histidine kinase activity
PF996_RS16570	COG5018	Exonuclease
PF996_RS16575	COG2814	Major facilitator Superfamily
PF996_RS16580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF996_RS16585	COG3011	Protein conserved in bacteria
PF996_RS16595	COG3290	protein histidine kinase activity
PF996_RS16600	COG4565	transcriptional regulatory protein
PF996_RS16605	COG1744	ABC transporter substrate-binding protein PnrA-like
PF996_RS16610	COG3845	ABC transporter
PF996_RS16615	COG4603	Belongs to the binding-protein-dependent transport system permease family
PF996_RS16620	COG1079	Belongs to the binding-protein-dependent transport system permease family
PF996_RS16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF996_RS16630	COG2111	Na H antiporter
PF996_RS16635	COG2111	Na H antiporter
PF996_RS16640	COG1006	Multisubunit Na H antiporter MnhC subunit
PF996_RS16645	COG0651	ATP synthesis coupled electron transport
PF996_RS16650	COG1863	multisubunit Na H antiporter MnhE subunit
PF996_RS16655	COG2212	antiporter activity
PF996_RS16660	COG1320	monovalent cation:proton antiporter activity
PF996_RS16665	COG2050	protein possibly involved in aromatic compounds catabolism
PF996_RS16670	COG2197	response regulator
PF996_RS16675	COG4585	Histidine kinase
PF996_RS16685	COG0142	geranyltranstransferase activity
PF996_RS16700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PF996_RS16705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PF996_RS16710	COG1335	isochorismatase
PF996_RS16715	COG5506	Protein of unknown function (DUF1694)
PF996_RS16730	COG0628	permease
PF996_RS16740	COG1418	mRNA catabolic process
PF996_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS16755	COG1511	domain protein
PF996_RS16760	COG0433	COG0433 Predicted ATPase
PF996_RS16760	COG1674	ftsk spoiiie
PF996_RS16765	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF996_RS16770	COG5417	Belongs to the EsaB family
PF996_RS16775	COG4842	Belongs to the WXG100 family
PF996_RS16780	COG2508	Transcriptional regulator
PF996_RS16780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF996_RS16785	COG0686	Belongs to the AlaDH PNT family
PF996_RS16790	COG5634	Uncharacterized conserved protein (DUF2278)
PF996_RS16795	COG3251	PFAM MbtH domain protein
PF996_RS16800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF996_RS16805	COG3433	isochorismatase activity
PF996_RS16805	COG1535	isochorismatase
PF996_RS16810	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF996_RS16815	COG1169	isochorismate synthase
PF996_RS16820	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS16825	COG2819	hydrolase of the alpha beta superfamily
PF996_RS16830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF996_RS16835	COG1268	BioY protein
PF996_RS16840	COG2056	Na+-H+ antiporter family
PF996_RS16850	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
PF996_RS16855	COG3584	3D domain protein
PF996_RS16870	COG1252	NADH dehydrogenase
PF996_RS16900	COG1131	(ABC) transporter
PF996_RS16920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF996_RS16925	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PF996_RS16930	COG0316	Belongs to the HesB IscA family
PF996_RS16940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF996_RS16950	COG1252	NADH dehydrogenase
PF996_RS16955	COG4837	Protein of unknown function (DUF1462)
PF996_RS16960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PF996_RS16965	COG0823	Involved in the tonB-independent uptake of proteins
PF996_RS16965	COG4946	Tricorn protease homolog
PF996_RS16965	COG1506	peptidase
PF996_RS16975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF996_RS16980	COG0460	homoserine dehydrogenase
PF996_RS16985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF996_RS16990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF996_RS16995	COG0647	UMP catabolic process
PF996_RS17000	COG2445	Protein of unknown function DUF86
PF996_RS17005	COG4470	Protein conserved in bacteria
PF996_RS17015	COG0739	heme binding
PF996_RS17025	COG0737	Belongs to the 5'-nucleotidase family
PF996_RS17030	COG0730	response to heat
PF996_RS17035	COG1801	Protein of unknown function DUF72
PF996_RS17050	COG2508	Transcriptional regulator
PF996_RS17055	COG0457	Tetratricopeptide repeat
PF996_RS17070	COG2814	Major facilitator Superfamily
PF996_RS17075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF996_RS17080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF996_RS17085	COG2356	endonuclease I
PF996_RS17090	COG3842	ATPase activity
PF996_RS17095	COG2188	Transcriptional regulator
PF996_RS17100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF996_RS17105	COG0395	ABC-type sugar transport system, permease component
PF996_RS17110	COG1175	transmembrane transport
PF996_RS17115	COG1653	transport
PF996_RS17120	COG2222	sugar isomerase
PF996_RS17125	COG0789	Transcriptional regulator
PF996_RS17150	COG0322	excinuclease ABC activity
PF996_RS17155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF996_RS17160	COG2226	methyltransferase
PF996_RS17170	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS17175	COG0719	Fe-S assembly protein
PF996_RS17180	COG0822	iron-sulfur transferase activity
PF996_RS17185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF996_RS17190	COG0719	Fe-S assembly protein
PF996_RS17195	COG0396	ATPase activity
PF996_RS17205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF996_RS17210	COG1464	Belongs to the NlpA lipoprotein family
PF996_RS17215	COG2011	ABC-type metal ion transport system permease component
PF996_RS17220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF996_RS17230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF996_RS17235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF996_RS17250	COG1393	Belongs to the ArsC family
PF996_RS17255	COG1960	acyl-CoA dehydrogenase activity
PF996_RS17260	COG0183	Belongs to the thiolase family
PF996_RS17265	COG1024	Enoyl-CoA hydratase
PF996_RS17265	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF996_RS17285	COG5577	PFAM Coat F domain
PF996_RS17290	COG1846	Transcriptional regulator
PF996_RS17295	COG0477	Major facilitator Superfamily
PF996_RS17300	COG0583	DNA-binding transcription factor activity
PF996_RS17320	COG1120	ATPase activity
PF996_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS17340	COG0783	Belongs to the Dps family
PF996_RS17345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF996_RS17350	COG0745	RESPONSE REGULATOR receiver
PF996_RS17355	COG2205	protein histidine kinase activity
PF996_RS17355	COG2770	Histidine kinase
PF996_RS17365	COG1309	transcriptional regulator
PF996_RS17370	COG0114	fumarate hydratase activity
PF996_RS17380	COG0697	spore germination
PF996_RS17385	COG0814	amino acid
PF996_RS17395	COG2197	response regulator
PF996_RS17400	COG4585	Histidine kinase
PF996_RS17405	COG4758	membrane
PF996_RS17410	COG3595	metallopeptidase activity
PF996_RS17415	COG1842	Phage shock protein A
PF996_RS17420	COG4758	membrane
PF996_RS17425	COG2814	Major facilitator Superfamily
PF996_RS17430	COG2096	Adenosyltransferase
PF996_RS17435	COG1120	ATPase activity
PF996_RS17440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS17445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF996_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS17455	COG3386	PFAM SMP-30 Gluconolaconase
PF996_RS17460	COG2205	protein histidine kinase activity
PF996_RS17465	COG0745	RESPONSE REGULATOR receiver
PF996_RS17475	COG1191	sigma factor activity
PF996_RS17485	COG2140	Oxalate decarboxylase
PF996_RS17495	COG1120	ATPase activity
PF996_RS17500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS17505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS17510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF996_RS17515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF996_RS17520	COG0531	amino acid
PF996_RS17530	COG1988	membrane-bound metal-dependent
PF996_RS17535	COG1368	sulfuric ester hydrolase activity
PF996_RS17540	COG1910	domain protein
PF996_RS17545	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF996_RS17550	COG4149	molybdate abc transporter
PF996_RS17555	COG2197	response regulator
PF996_RS17560	COG3850	Histidine kinase
PF996_RS17565	COG1131	(ABC) transporter
PF996_RS17575	COG0842	Transport permease protein
PF996_RS17580	COG0656	L-ascorbic acid biosynthetic process
PF996_RS17600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF996_RS17605	COG3973	AAA domain
PF996_RS17610	COG2860	membrane
PF996_RS17620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF996_RS17625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF996_RS17630	COG2217	Heavy metal translocating P-type atpase
PF996_RS17635	COG2217	Heavy metal translocating P-type atpase
PF996_RS17640	COG2608	mercury ion transmembrane transporter activity
PF996_RS17645	COG1937	Protein conserved in bacteria
PF996_RS17650	COG0673	inositol 2-dehydrogenase activity
PF996_RS17665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS17670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF996_RS17675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS17680	COG1126	abc transporter atp-binding protein
PF996_RS17685	COG0765	amino acid transport
PF996_RS17690	COG0765	amino acid transport
PF996_RS17695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS17700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF996_RS17705	COG0454	-acetyltransferase
PF996_RS17710	COG0583	DNA-binding transcription factor activity
PF996_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS17720	COG2732	(Barnase) inhibitor
PF996_RS17735	COG0557	exoribonuclease II activity
PF996_RS17740	COG1647	Serine aminopeptidase, S33
PF996_RS17745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF996_RS17750	COG1476	TRANSCRIPTIONal
PF996_RS17755	COG1396	sequence-specific DNA binding
PF996_RS17760	COG1396	sequence-specific DNA binding
PF996_RS17765	COG1733	regulation of RNA biosynthetic process
PF996_RS17790	COG1131	(ABC) transporter
PF996_RS17795	COG1174	glycine betaine transport
PF996_RS17800	COG1732	Glycine betaine
PF996_RS17805	COG1174	glycine betaine transport
PF996_RS17810	COG0517	IMP dehydrogenase activity
PF996_RS17810	COG1125	glycine betaine transport
PF996_RS17815	COG1510	regulation of RNA biosynthetic process
PF996_RS17820	COG1174	glycine betaine transport
PF996_RS17825	COG1732	Glycine betaine
PF996_RS17830	COG1174	glycine betaine transport
PF996_RS17835	COG1125	glycine betaine transport
PF996_RS17835	COG0517	IMP dehydrogenase activity
PF996_RS17840	COG1510	regulation of RNA biosynthetic process
PF996_RS17845	COG2095	MarC family integral membrane protein
PF996_RS17850	COG3064	Membrane
PF996_RS17855	COG4640	response to antibiotic
PF996_RS17860	COG0456	acetyltransferase
PF996_RS17915	COG0126	phosphoglycerate kinase activity
PF996_RS17920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF996_RS17925	COG2390	Transcriptional regulator
PF996_RS17930	COG2814	Major facilitator Superfamily
PF996_RS17935	COG1609	Transcriptional regulator
PF996_RS17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS17955	COG0583	DNA-binding transcription factor activity
PF996_RS17960	COG0697	spore germination
PF996_RS17965	COG1113	amino acid transport
PF996_RS17975	COG1609	Transcriptional regulator
PF996_RS17985	COG0561	phosphatase activity
PF996_RS17990	COG1737	Transcriptional regulator
PF996_RS17995	COG1070	Carbohydrate kinase
PF996_RS18020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS18025	COG2186	Transcriptional regulator
PF996_RS18030	COG1620	l-lactate permease
PF996_RS18035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PF996_RS18045	COG5039	Polysaccharide pyruvyl transferase
PF996_RS18050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF996_RS18055	COG0110	maltose O-acetyltransferase activity
PF996_RS18060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF996_RS18065	COG2244	polysaccharide biosynthetic process
PF996_RS18070	COG1216	Glycosyl transferase, family 2
PF996_RS18075	COG5039	Polysaccharide pyruvyl transferase
PF996_RS18080	COG1216	Glycosyl transferase, family 2
PF996_RS18090	COG0438	transferase activity, transferring glycosyl groups
PF996_RS18095	COG1215	transferase activity, transferring glycosyl groups
PF996_RS18100	COG0438	transferase activity, transferring glycosyl groups
PF996_RS18105	COG1086	Polysaccharide biosynthesis protein
PF996_RS18110	COG0489	protein tyrosine kinase activity
PF996_RS18115	COG3944	biosynthesis protein
PF996_RS18120	COG1396	sequence-specific DNA binding
PF996_RS18125	COG2272	Belongs to the type-B carboxylesterase lipase family
PF996_RS18135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF996_RS18140	COG2364	Membrane
PF996_RS18145	COG0456	acetyltransferase
PF996_RS18150	COG3479	Phenolic acid decarboxylase
PF996_RS18190	COG2223	nitrite transmembrane transporter activity
PF996_RS18195	COG1609	Transcriptional regulator
PF996_RS18205	COG0583	DNA-binding transcription factor activity
PF996_RS18210	COG2828	Protein conserved in bacteria
PF996_RS18215	COG0477	Major facilitator Superfamily
PF996_RS18215	COG2814	Major facilitator Superfamily
PF996_RS18220	COG1611	Belongs to the LOG family
PF996_RS18225	COG1694	Mazg nucleotide pyrophosphohydrolase
PF996_RS18230	COG0659	secondary active sulfate transmembrane transporter activity
PF996_RS18235	COG0288	reversible hydration of carbon dioxide
PF996_RS18240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF996_RS18245	COG4290	ribonuclease
PF996_RS18250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PF996_RS18255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS18265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PF996_RS18275	COG1051	belongs to the nudix hydrolase family
PF996_RS18280	COG0492	ferredoxin-NADP+ reductase activity
PF996_RS18285	COG0791	NLP P60 protein
PF996_RS18285	COG3883	PFAM NLP P60 protein
PF996_RS18290	COG0457	Tetratricopeptide repeat
PF996_RS18295	COG5002	protein histidine kinase activity
PF996_RS18300	COG0745	RESPONSE REGULATOR receiver
PF996_RS18310	COG1132	(ABC) transporter
PF996_RS18315	COG0140	phosphoribosyl-ATP diphosphatase activity
PF996_RS18315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF996_RS18340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF996_RS18355	COG4990	cell redox homeostasis
PF996_RS18360	COG0110	maltose O-acetyltransferase activity
PF996_RS18380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PF996_RS18390	COG2188	Transcriptional regulator
PF996_RS18395	COG1309	transcriptional regulator
PF996_RS18400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF996_RS18405	COG1950	PFAM Membrane protein of
PF996_RS18410	COG1983	PspC domain protein
PF996_RS18415	COG3595	metallopeptidase activity
PF996_RS18430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF996_RS18440	COG4897	Protein conserved in bacteria
PF996_RS18445	COG0574	Belongs to the PEP-utilizing enzyme family
PF996_RS18445	COG3848	Pyruvate phosphate dikinase
PF996_RS18450	COG1309	transcriptional regulator
PF996_RS18455	COG2814	Major facilitator Superfamily
PF996_RS18465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF996_RS18475	COG3409	Peptidoglycan-binding domain 1 protein
PF996_RS18475	COG0793	Belongs to the peptidase S41A family
PF996_RS18480	COG3420	alginic acid biosynthetic process
PF996_RS18485	COG2177	Part of the ABC transporter FtsEX involved in
PF996_RS18490	COG2884	Cell division ATP-binding protein ftsE
PF996_RS18495	COG2010	Cytochrome c
PF996_RS18500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS18515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PF996_RS18530	COG1516	flagellar protein fliS
PF996_RS18535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PF996_RS18540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF996_RS18560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF996_RS18565	COG4786	Flagellar basal body rod
PF996_RS18565	COG1256	bacterial-type flagellum assembly
PF996_RS18570	COG3418	PFAM FlgN family protein
PF996_RS18575	COG2747	anti-sigma28 factor FlgM
PF996_RS18585	COG1040	competence protein
PF996_RS18595	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PF996_RS18600	COG1307	EDD domain protein, DegV family
PF996_RS18605	COG2197	response regulator
PF996_RS18610	COG4585	Histidine kinase
PF996_RS18615	COG1739	Uncharacterized protein family UPF0029
PF996_RS18620	COG1316	TRANSCRIPTIONal
PF996_RS18625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF996_RS18630	COG0438	transferase activity, transferring glycosyl groups
PF996_RS18635	COG1215	transferase activity, transferring glycosyl groups
PF996_RS18640	COG3206	protein involved in exopolysaccharide biosynthesis
PF996_RS18645	COG3307	-O-antigen
PF996_RS18650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF996_RS18655	COG0438	transferase activity, transferring glycosyl groups
PF996_RS18655	COG0297	glycogen (starch) synthase activity
PF996_RS18660	COG2244	polysaccharide biosynthetic process
PF996_RS18670	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF996_RS18670	COG2247	cell wall binding repeat
PF996_RS18675	COG2247	cell wall binding repeat
PF996_RS18675	COG2385	sporulation resulting in formation of a cellular spore
PF996_RS18685	COG1316	TRANSCRIPTIONal
PF996_RS18690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PF996_RS18695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF996_RS18700	COG1134	teichoic acid transport
PF996_RS18705	COG1682	transport, permease protein
PF996_RS18710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF996_RS18715	COG0438	transferase activity, transferring glycosyl groups
PF996_RS18720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PF996_RS18725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PF996_RS18730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF996_RS18735	COG4193	domain, Protein
PF996_RS18740	COG1482	cell wall glycoprotein biosynthetic process
PF996_RS18745	COG0697	spore germination
PF996_RS18750	COG0814	amino acid
PF996_RS18760	COG1215	transferase activity, transferring glycosyl groups
PF996_RS18765	COG2814	Major facilitator Superfamily
PF996_RS18770	COG1316	TRANSCRIPTIONal
PF996_RS18775	COG0561	phosphatase activity
PF996_RS18780	COG2433	Pfam Transposase IS66
PF996_RS18785	COG0791	NLP P60 protein
PF996_RS18795	COG2843	Capsule synthesis protein
PF996_RS18805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF996_RS18810	COG0697	spore germination
PF996_RS18815	COG0814	amino acid
PF996_RS18825	COG1609	Transcriptional regulator
PF996_RS18830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF996_RS18840	COG1129	ABC transporter
PF996_RS18845	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF996_RS18850	COG1879	ABC-type sugar transport system periplasmic component
PF996_RS18855	COG3103	Sh3 type 3 domain protein
PF996_RS18860	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF996_RS18865	COG3527	Alpha-acetolactate decarboxylase
PF996_RS18870	COG0028	Belongs to the TPP enzyme family
PF996_RS18875	COG0583	DNA-binding transcription factor activity
PF996_RS18880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF996_RS18895	COG5337	Spore coat protein CotH
PF996_RS18905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF996_RS18915	COG0405	Gamma-glutamyltransferase
PF996_RS18920	COG1522	sequence-specific DNA binding
PF996_RS18925	COG2059	Chromate
PF996_RS18930	COG2059	Chromate
PF996_RS18940	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF996_RS18945	COG0583	DNA-binding transcription factor activity
PF996_RS18985	COG5444	nuclease activity
PF996_RS19000	COG3878	Protein conserved in bacteria
PF996_RS19005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF996_RS19010	COG4464	protein tyrosine phosphatase activity
PF996_RS19015	COG0489	protein tyrosine kinase activity
PF996_RS19020	COG3944	biosynthesis protein
PF996_RS19030	COG4715	Zinc finger, swim domain protein
PF996_RS19035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF996_RS19040	COG0561	phosphatase activity
PF996_RS19045	COG1349	DNA-binding transcription factor activity
PF996_RS19050	COG0629	single-stranded DNA binding
PF996_RS19075	COG0457	Tetratricopeptide repeat
PF996_RS19080	COG4786	Flagellar basal body rod
PF996_RS19085	COG4786	Flagellar basal body rod
PF996_RS19090	COG1077	Cell shape determining protein MreB Mrl
PF996_RS19095	COG1609	Transcriptional regulator
PF996_RS19100	COG1846	Transcriptional regulator
PF996_RS19105	COG2814	Major facilitator Superfamily
PF996_RS19110	COG1953	Uracil, thiamine, allantoin
PF996_RS19115	COG0477	Major facilitator Superfamily
PF996_RS19120	COG1335	isochorismatase
PF996_RS19125	COG0004	ammonium transporteR
PF996_RS19130	COG0347	Belongs to the P(II) protein family
PF996_RS19135	COG0772	Belongs to the SEDS family
PF996_RS19140	COG0671	phosphoesterase, PA-phosphatase related
PF996_RS19150	COG0739	heme binding
PF996_RS19155	COG1247	-acetyltransferase
PF996_RS19170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF996_RS19180	COG0726	polysaccharide deacetylase
PF996_RS19185	COG1959	2 iron, 2 sulfur cluster binding
PF996_RS19200	COG0831	urea catabolic process
PF996_RS19210	COG1994	Peptidase M50
PF996_RS19215	COG0457	Tetratricopeptide repeat
PF996_RS19225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF996_RS19235	COG2304	oxidoreductase activity
PF996_RS19240	COG2304	oxidoreductase activity
PF996_RS19245	COG2385	sporulation resulting in formation of a cellular spore
PF996_RS19250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF996_RS19260	COG4836	Membrane
PF996_RS19330	COG0698	ribose 5-phosphate isomerase
PF996_RS19335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF996_RS19345	COG0009	L-threonylcarbamoyladenylate synthase
PF996_RS19350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PF996_RS19370	COG2890	protein-(glutamine-N5) methyltransferase activity
PF996_RS19375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PF996_RS19380	COG0346	lactoylglutathione lyase activity
PF996_RS19385	COG0789	Transcriptional regulator
PF996_RS19390	COG0679	Auxin Efflux Carrier
PF996_RS19395	COG0281	malic enzyme
PF996_RS19410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PF996_RS19420	COG1494	fructose-1,6-bisphosphatase
PF996_RS19425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF996_RS19435	COG0191	fructose-bisphosphate aldolase activity
PF996_RS19440	COG2204	response regulator
PF996_RS19445	COG4821	SIS domain
PF996_RS19460	COG2181	nitrate reductase activity
PF996_RS19460	COG0247	lactate metabolic process
PF996_RS19465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF996_RS19480	COG1132	(ABC) transporter
PF996_RS19485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF996_RS19495	COG2181	nitrate reductase activity
PF996_RS19500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
PF996_RS19505	COG1140	nitrate reductase beta subunit
PF996_RS19510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PF996_RS19515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF996_RS19525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF996_RS19530	COG2223	nitrite transmembrane transporter activity
PF996_RS19540	COG4506	Protein conserved in bacteria
PF996_RS19545	COG0457	Tetratricopeptide repeat
PF996_RS19555	COG0010	Belongs to the arginase family
PF996_RS19560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PF996_RS19565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF996_RS19580	COG1994	Peptidase M50
PF996_RS19585	COG1942	4-Oxalocrotonate Tautomerase
PF996_RS19590	COG1846	Transcriptional regulator
PF996_RS19595	COG0531	amino acid
PF996_RS19600	COG3465	dGTPase activity
PF996_RS19605	COG1078	dGTPase activity
PF996_RS19620	COG1695	Transcriptional regulator
PF996_RS19630	COG1131	(ABC) transporter
PF996_RS19635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF996_RS19665	COG0583	DNA-binding transcription factor activity
PF996_RS19670	COG2855	membrane
PF996_RS19675	COG0280	phosphate acetyltransferase
PF996_RS19700	COG3118	belongs to the thioredoxin family
PF996_RS19705	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS19710	COG0436	Aminotransferase
PF996_RS19740	COG2814	Major facilitator Superfamily
PF996_RS19745	COG2814	Major facilitator Superfamily
PF996_RS19755	COG4187	Peptidase family M20/M25/M40
PF996_RS19760	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS19765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF996_RS19770	COG2205	protein histidine kinase activity
PF996_RS19775	COG0745	RESPONSE REGULATOR receiver
PF996_RS19790	COG1131	(ABC) transporter
PF996_RS19795	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PF996_RS19800	COG1091	dTDP-4-dehydrorhamnose reductase activity
PF996_RS19805	COG1088	dTDP-glucose 4,6-dehydratase activity
PF996_RS19810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PF996_RS19815	COG3980	spore coat polysaccharide biosynthesis protein
PF996_RS19820	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PF996_RS19825	COG2089	acid synthase
PF996_RS19830	COG0456	acetyltransferase
PF996_RS19835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF996_RS19845	COG0463	Glycosyl transferase, family 2
PF996_RS19855	COG2363	Small membrane protein
PF996_RS19860	COG2233	PERMEase
PF996_RS19875	COG1216	Glycosyl transferase, family 2
PF996_RS19890	COG1695	Transcriptional regulator
PF996_RS19895	COG0351	phosphomethylpyrimidine kinase
PF996_RS19905	COG1621	beta-fructofuranosidase activity
PF996_RS19910	COG1263	PTS System
PF996_RS19910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF996_RS19915	COG3711	transcriptional antiterminator
PF996_RS19925	COG1404	Belongs to the peptidase S8 family
PF996_RS19930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF996_RS19935	COG0778	Nitroreductase
PF996_RS19940	COG0772	Belongs to the SEDS family
PF996_RS19945	COG0454	-acetyltransferase
PF996_RS19965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF996_RS19970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF996_RS19975	COG2261	transglycosylase associated protein
PF996_RS19980	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PF996_RS19985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PF996_RS19990	COG2246	polysaccharide biosynthetic process
PF996_RS19995	COG1309	transcriptional regulator
PF996_RS20015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF996_RS20020	COG2837	iron assimilation
PF996_RS20035	COG0583	DNA-binding transcription factor activity
PF996_RS20045	COG1346	cytolysis
PF996_RS20050	COG1131	(ABC) transporter
PF996_RS20075	COG4895	conserved protein (DUF2196)
PF996_RS20080	COG0789	Transcriptional regulator
PF996_RS20085	COG5504	Zn-dependent protease
PF996_RS20090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF996_RS20095	COG0346	lactoylglutathione lyase activity
PF996_RS20100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS20105	COG1404	Belongs to the peptidase S8 family
PF996_RS20110	COG1442	glycosyl transferase family 8
PF996_RS20115	COG1846	Transcriptional regulator
PF996_RS20120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF996_RS20125	COG2357	RelA SpoT domain protein
PF996_RS20130	COG1575	Belongs to the MenA family. Type 1 subfamily
PF996_RS20145	COG1696	Membrane protein involved in D-alanine export
PF996_RS20155	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PF996_RS20160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF996_RS20165	COG1486	melibiose metabolic process
PF996_RS20170	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF996_RS20175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS20180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS20185	COG3711	transcriptional antiterminator
PF996_RS20185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF996_RS20200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS20205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF996_RS20215	COG0640	Transcriptional regulator
PF996_RS20220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF996_RS20225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS20230	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF996_RS20235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF996_RS20240	COG2723	6-phospho-beta-galactosidase activity
PF996_RS20245	COG1940	carbohydrate kinase activity
PF996_RS20250	COG1482	cell wall glycoprotein biosynthetic process
PF996_RS20260	COG0753	catalase activity
PF996_RS20265	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PF996_RS20270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF996_RS20275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF996_RS20280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PF996_RS20285	COG4988	ABC transporter
PF996_RS20290	COG1294	oxidase, subunit
PF996_RS20295	COG1271	oxidase subunit
PF996_RS20300	COG3493	citrate carrier protein
PF996_RS20305	COG0726	polysaccharide deacetylase
PF996_RS20310	COG3842	ATPase activity
PF996_RS20315	COG2508	Transcriptional regulator
PF996_RS20320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS20330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF996_RS20345	COG4894	glucomannan catabolic process
PF996_RS20350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF996_RS20355	COG0500	methyltransferase
PF996_RS20360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF996_RS20380	COG0693	protein deglycase activity
PF996_RS20380	COG0753	catalase activity
PF996_RS20385	COG2851	Citrate transporter
PF996_RS20390	COG2273	Hydrolase Family 16
PF996_RS20405	COG0513	Belongs to the DEAD box helicase family
PF996_RS20470	COG3209	COG3209 Rhs family protein
PF996_RS20480	COG0697	spore germination
PF996_RS20485	COG0589	response to stress
PF996_RS20495	COG0494	nUDIX hydrolase
PF996_RS20500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PF996_RS20505	COG3507	Belongs to the glycosyl hydrolase 43 family
PF996_RS20530	COG0010	Belongs to the arginase family
PF996_RS20535	COG0833	amino acid
PF996_RS20540	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PF996_RS20545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF996_RS20555	COG2390	Transcriptional regulator
PF996_RS20585	COG1131	(ABC) transporter
PF996_RS20595	COG0561	phosphatase activity
PF996_RS20625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF996_RS20630	COG5294	Protein conserved in bacteria
PF996_RS20635	COG0577	efflux transmembrane transporter activity
PF996_RS20640	COG1136	(ABC) transporter
PF996_RS20645	COG2205	protein histidine kinase activity
PF996_RS20650	COG0745	RESPONSE REGULATOR receiver
PF996_RS20665	COG1082	Xylose isomerase domain protein TIM barrel
PF996_RS20675	COG2814	Major facilitator Superfamily
PF996_RS20705	COG1349	DNA-binding transcription factor activity
PF996_RS20710	COG0667	Aldo Keto reductase
PF996_RS20715	COG2814	Major facilitator Superfamily
PF996_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
PF996_RS20735	COG2197	response regulator
PF996_RS20740	COG4585	Histidine kinase
PF996_RS20745	COG3239	Fatty acid desaturase
PF996_RS20750	COG1309	transcriptional regulator
PF996_RS20760	COG1476	TRANSCRIPTIONal
PF996_RS20790	COG3328	transposase activity
PF996_RS20795	COG1012	belongs to the aldehyde dehydrogenase family
PF996_RS20810	COG0640	Transcriptional regulator
PF996_RS20815	COG2814	Major facilitator Superfamily
PF996_RS20820	COG1714	RDD family
PF996_RS20830	COG0450	alkyl hydroperoxide reductase
PF996_RS20835	COG3634	alkyl hydroperoxide reductase activity
PF996_RS20840	COG3177	Filamentation induced by cAMP protein fic
PF996_RS20845	COG1113	amino acid transport
PF996_RS20855	COG2080	2 iron, 2 sulfur cluster binding
PF996_RS20870	COG2068	MobA-Related Protein
PF996_RS20875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PF996_RS20925	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PF996_RS20930	COG0667	Aldo Keto reductase
PF996_RS20935	COG0456	acetyltransferase
PF996_RS20945	COG0457	Tetratricopeptide repeat
PF996_RS20950	COG0010	Belongs to the arginase family
PF996_RS20955	COG0833	amino acid
PF996_RS20960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF996_RS20965	COG5658	integral membrane protein
PF996_RS20970	COG0640	Transcriptional regulator
PF996_RS20975	COG3829	transcription factor binding
PF996_RS20985	COG0488	(ABC) transporter
PF996_RS21000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF996_RS21005	COG3850	Histidine kinase
PF996_RS21005	COG5002	protein histidine kinase activity
PF996_RS21010	COG0745	RESPONSE REGULATOR receiver
PF996_RS21025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF996_RS21030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF996_RS21035	COG4853	Protein conserved in bacteria
PF996_RS21040	COG4863	YycH protein
PF996_RS21045	COG5002	protein histidine kinase activity
PF996_RS21050	COG0745	RESPONSE REGULATOR receiver
PF996_RS21080	COG0346	lactoylglutathione lyase activity
PF996_RS21085	COG0305	Participates in initiation and elongation during chromosome replication
PF996_RS21100	COG3093	addiction module antidote protein HigA
PF996_RS21105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF996_RS21110	COG0297	glycogen (starch) synthase activity
PF996_RS21120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF996_RS21125	COG0438	transferase activity, transferring glycosyl groups
PF996_RS21145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PF996_RS21150	COG4241	membrane
PF996_RS21160	COG5577	PFAM Coat F domain
PF996_RS21165	COG1733	regulation of RNA biosynthetic process
PF996_RS21175	COG0697	spore germination
PF996_RS21180	COG1621	beta-fructofuranosidase activity
PF996_RS21185	COG1621	beta-fructofuranosidase activity
PF996_RS21195	COG2318	DinB family
PF996_RS21200	COG2211	Major facilitator Superfamily
PF996_RS21205	COG0697	spore germination
PF996_RS21215	COG0778	Nitroreductase
PF996_RS21220	COG1846	Transcriptional regulator
PF996_RS21225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF996_RS21230	COG1846	Transcriptional regulator
PF996_RS21235	COG2153	protein acetylation
PF996_RS21240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF996_RS21245	COG0697	spore germination
PF996_RS21285	COG1131	(ABC) transporter
PF996_RS21295	COG3328	transposase activity
PF996_RS21300	COG1331	Highly conserved protein containing a thioredoxin domain
PF996_RS21305	COG1266	CAAX protease self-immunity
PF996_RS21310	COG0477	Major facilitator Superfamily
PF996_RS21310	COG2814	Major facilitator Superfamily
PF996_RS21315	COG0346	lactoylglutathione lyase activity
PF996_RS21320	COG1609	Transcriptional regulator
PF996_RS21325	COG0708	Exodeoxyribonuclease III
PF996_RS21330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF996_RS21335	COG2169	Transcriptional regulator
PF996_RS21345	COG0629	single-stranded DNA binding
PF996_RS21355	COG0012	GTP binding
PF996_RS21360	COG0243	molybdopterin cofactor binding
PF996_RS21365	COG4481	Protein conserved in bacteria
PF996_RS21370	COG3949	Membrane
PF996_RS21385	COG1475	DNA binding
PF996_RS21390	COG1192	Involved in chromosome partitioning
PF996_RS21415	COG1847	R3H domain protein
PF996_RS21420	COG0706	membrane insertase activity
PF996_RS21440	COG2002	toxin-antitoxin pair type II binding
PF996_RS21480	COG2003	Belongs to the UPF0758 family
PF996_RS21515	COG3209	COG3209 Rhs family protein
PF996_RS21535	COG3883	PFAM NLP P60 protein
PF996_RS21535	COG0791	NLP P60 protein
PF996_RS21580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF996_RS21635	COG0328	RNA-DNA hybrid ribonuclease activity
PF996_RS21655	COG3209	COG3209 Rhs family protein
PF996_RS21675	COG2003	Belongs to the UPF0758 family
PF996_RS21745	COG3764	Sortase (surface protein transpeptidase)
PF996_RS21770	COG0457	Tetratricopeptide repeat
PF996_RS21790	COG3328	transposase activity
PF996_RS21830	COG0582	viral genome integration into host DNA