locus-tag	class	description
M8970_RS00095	COG3340	Belongs to the peptidase S51 family
M8970_RS00105	COG0277	FAD linked oxidase domain protein
M8970_RS00115	COG0747	negative chemotaxis
M8970_RS00120	COG0601	transmembrane transport
M8970_RS00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8970_RS00130	COG0444	Belongs to the ABC transporter superfamily
M8970_RS00135	COG4608	Belongs to the ABC transporter superfamily
M8970_RS00140	COG0753	catalase activity
M8970_RS00150	COG1116	anion transmembrane transporter activity
M8970_RS00155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8970_RS00160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8970_RS00180	COG1476	TRANSCRIPTIONal
M8970_RS00190	COG3382	B3 4 domain protein
M8970_RS00195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8970_RS00205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M8970_RS00210	COG0789	Transcriptional regulator
M8970_RS00215	COG1664	Polymer-forming cytoskeletal
M8970_RS00220	COG1664	Polymer-forming cytoskeletal
M8970_RS00225	COG2766	serine protein kinase
M8970_RS00235	COG1846	Transcriptional regulator
M8970_RS00240	COG1566	PFAM secretion protein HlyD family protein
M8970_RS00245	COG2814	Major facilitator Superfamily
M8970_RS00250	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8970_RS00265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8970_RS00270	COG1278	Cold shock
M8970_RS00275	COG1464	Belongs to the NlpA lipoprotein family
M8970_RS00280	COG3706	GGDEF domain
M8970_RS00285	COG1823	symporter activity
M8970_RS00305	COG5577	PFAM Coat F domain
M8970_RS00310	COG0737	Belongs to the 5'-nucleotidase family
M8970_RS00310	COG1525	nuclease
M8970_RS00310	COG4085	toxin activity
M8970_RS00315	COG3764	Sortase (surface protein transpeptidase)
M8970_RS00320	COG0564	pseudouridine synthase activity
M8970_RS00330	COG0517	IMP dehydrogenase activity
M8970_RS00335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8970_RS00340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8970_RS00340	COG3153	acetyltransferase
M8970_RS00345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8970_RS00350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M8970_RS00355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M8970_RS00365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M8970_RS00370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8970_RS00375	COG2203	Gaf domain
M8970_RS00375	COG4585	Histidine kinase
M8970_RS00380	COG2197	response regulator
M8970_RS00385	COG0431	NADPH-dependent FMN reductase
M8970_RS00400	COG0791	NLP P60 protein
M8970_RS00400	COG1388	LysM domain
M8970_RS00405	COG1959	2 iron, 2 sulfur cluster binding
M8970_RS00415	COG2719	SpoVR family
M8970_RS00420	COG1785	Belongs to the alkaline phosphatase family
M8970_RS00425	COG0791	NLP P60 protein
M8970_RS00425	COG1388	LysM domain
M8970_RS00430	COG0583	DNA-binding transcription factor activity
M8970_RS00435	COG0372	Belongs to the citrate synthase family
M8970_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS00445	COG0531	amino acid
M8970_RS00450	COG0733	neurotransmitter:sodium symporter activity
M8970_RS00465	COG1595	DNA-templated transcription, initiation
M8970_RS00470	COG0204	Acyl-transferase
M8970_RS00475	COG1253	flavin adenine dinucleotide binding
M8970_RS00480	COG0789	Transcriptional regulator
M8970_RS00485	COG0436	Aminotransferase
M8970_RS00490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8970_RS00495	COG1253	flavin adenine dinucleotide binding
M8970_RS00500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8970_RS00505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8970_RS00510	COG0584	glycerophosphoryl diester phosphodiesterase
M8970_RS00520	COG0668	transmembrane transport
M8970_RS00525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M8970_RS00530	COG0726	polysaccharide deacetylase
M8970_RS00535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8970_RS00540	COG3226	Transcriptional regulator
M8970_RS00550	COG0589	response to stress
M8970_RS00555	COG1132	(ABC) transporter
M8970_RS00560	COG1132	(ABC) transporter
M8970_RS00565	COG0702	epimerase
M8970_RS00585	COG0189	ligase activity
M8970_RS00590	COG0189	ligase activity
M8970_RS00605	COG4335	DNA alkylation repair
M8970_RS00610	COG0561	phosphatase activity
M8970_RS00615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8970_RS00625	COG0475	glutathione-regulated potassium exporter activity
M8970_RS00630	COG0490	domain, Protein
M8970_RS00640	COG1024	Enoyl-CoA hydratase
M8970_RS00650	COG4152	abc transporter atp-binding protein
M8970_RS00655	COG1668	transmembrane transport
M8970_RS00660	COG0420	3'-5' exonuclease activity
M8970_RS00665	COG4717	serine-type aminopeptidase activity
M8970_RS00680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8970_RS00715	COG4980	gas vesicle protein
M8970_RS00730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M8970_RS00735	COG0537	adenosine 5'-monophosphoramidase activity
M8970_RS00740	COG1131	(ABC) transporter
M8970_RS00745	COG4473	ABC transporter
M8970_RS00755	COG1473	amidohydrolase
M8970_RS00760	COG3069	C4-dicarboxylate transmembrane transporter activity
M8970_RS00765	COG2329	Antibiotic biosynthesis monooxygenase
M8970_RS00770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8970_RS00780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M8970_RS00785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M8970_RS00790	COG1309	transcriptional regulator
M8970_RS00795	COG1511	domain protein
M8970_RS00800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8970_RS00810	COG1363	Peptidase, m42
M8970_RS00815	COG1301	dicarboxylic acid transport
M8970_RS00825	COG1234	tRNA 3'-trailer cleavage
M8970_RS00830	COG0095	Lipoate-protein ligase
M8970_RS00835	COG0702	epimerase
M8970_RS00840	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS00850	COG0501	Belongs to the peptidase M48B family
M8970_RS00855	COG1404	Belongs to the peptidase S8 family
M8970_RS00860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M8970_RS00865	COG0406	alpha-ribazole phosphatase activity
M8970_RS00870	COG0183	Belongs to the thiolase family
M8970_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS00880	COG1268	BioY protein
M8970_RS00885	COG0840	transmembrane signaling receptor activity
M8970_RS00890	COG0723	plastoquinol--plastocyanin reductase activity
M8970_RS00890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8970_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS00905	COG4903	ComK protein
M8970_RS00915	COG5646	InterPro IPR014922
M8970_RS00935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8970_RS00950	COG0398	Pfam SNARE associated Golgi protein
M8970_RS00955	COG0681	Belongs to the peptidase S26 family
M8970_RS00960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8970_RS00965	COG1846	Transcriptional regulator
M8970_RS00970	COG3180	Ammonia monooxygenase
M8970_RS00975	COG2814	Major facilitator Superfamily
M8970_RS00985	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M8970_RS00990	COG2323	membrane
M8970_RS01005	COG0420	3'-5' exonuclease activity
M8970_RS01010	COG0419	ATPase involved in DNA repair
M8970_RS01015	COG1403	HNH endonuclease
M8970_RS01055	COG0179	Fumarylacetoacetate (FAA) hydrolase
M8970_RS01070	COG0367	asparagine synthase
M8970_RS01075	COG1562	ergosterol biosynthetic process
M8970_RS01080	COG0534	Mate efflux family protein
M8970_RS01085	COG2207	Transcriptional regulator
M8970_RS01085	COG1917	Cupin 2, conserved barrel domain protein
M8970_RS01095	COG2318	DinB family
M8970_RS01100	COG1279	arginine transmembrane transporter activity
M8970_RS01105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS01110	COG1357	PFAM Pentapeptide repeats (8 copies)
M8970_RS01115	COG2153	protein acetylation
M8970_RS01120	COG0646	methionine synthase
M8970_RS01120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M8970_RS01130	COG2996	Protein conserved in bacteria
M8970_RS01135	COG1744	ABC transporter substrate-binding protein PnrA-like
M8970_RS01140	COG0840	transmembrane signaling receptor activity
M8970_RS01145	COG2124	cytochrome p450
M8970_RS01155	COG1307	EDD domain protein, DegV family
M8970_RS01160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS01180	COG0561	phosphatase activity
M8970_RS01185	COG1073	alpha beta
M8970_RS01190	COG2151	metal-sulfur cluster biosynthetic enzyme
M8970_RS01200	COG0277	FAD linked oxidase domain protein
M8970_RS01205	COG2271	Major facilitator Superfamily
M8970_RS01215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M8970_RS01225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8970_RS01230	COG0505	Belongs to the CarA family
M8970_RS01235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8970_RS01240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8970_RS01255	COG2267	carboxylic ester hydrolase activity
M8970_RS01265	COG1744	ABC transporter substrate-binding protein PnrA-like
M8970_RS01280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8970_RS01285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8970_RS01290	COG5504	Zn-dependent protease
M8970_RS01295	COG0444	Belongs to the ABC transporter superfamily
M8970_RS01300	COG4608	Belongs to the ABC transporter superfamily
M8970_RS01310	COG0601	transmembrane transport
M8970_RS01315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8970_RS01325	COG0180	Tryptophanyl-tRNA synthetase
M8970_RS01330	COG4166	transmembrane transport
M8970_RS01335	COG0601	transmembrane transport
M8970_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8970_RS01345	COG0444	Belongs to the ABC transporter superfamily
M8970_RS01350	COG4608	Belongs to the ABC transporter superfamily
M8970_RS01360	COG0456	acetyltransferase
M8970_RS01365	COG1393	Belongs to the ArsC family
M8970_RS01370	COG0861	Integral membrane protein TerC family
M8970_RS01380	COG4862	establishment of competence for transformation
M8970_RS01385	COG4469	Competence protein
M8970_RS01390	COG1164	Oligoendopeptidase f
M8970_RS01400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8970_RS01405	COG2346	COG2346, Truncated hemoglobins
M8970_RS01410	COG0741	lytic transglycosylase activity
M8970_RS01415	COG4116	CYTH
M8970_RS01425	COG2357	RelA SpoT domain protein
M8970_RS01430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8970_RS01435	COG0564	pseudouridine synthase activity
M8970_RS01445	COG0475	glutathione-regulated potassium exporter activity
M8970_RS01445	COG0569	domain protein
M8970_RS01450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M8970_RS01455	COG0352	thiamine-phosphate diphosphorylase activity
M8970_RS01460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8970_RS01465	COG2104	thiamine diphosphate biosynthetic process
M8970_RS01475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8970_RS01480	COG0351	phosphomethylpyrimidine kinase
M8970_RS01485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M8970_RS01540	COG0210	DNA helicase
M8970_RS01560	COG1131	(ABC) transporter
M8970_RS01570	COG2153	protein acetylation
M8970_RS01580	COG2382	esterase
M8970_RS01585	COG0626	cystathionine gamma-synthase activity
M8970_RS01590	COG0626	cystathionine gamma-synthase activity
M8970_RS01620	COG5444	nuclease activity
M8970_RS01630	COG0346	lactoylglutathione lyase activity
M8970_RS01635	COG2367	Beta-lactamase
M8970_RS01640	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8970_RS01645	COG0477	Major facilitator Superfamily
M8970_RS01650	COG1846	Transcriptional regulator
M8970_RS01660	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8970_RS01665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8970_RS01670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8970_RS01675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS01675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS01680	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8970_RS01690	COG1349	DNA-binding transcription factor activity
M8970_RS01710	COG1285	pathogenesis
M8970_RS01725	COG2205	protein histidine kinase activity
M8970_RS01735	COG3383	formate dehydrogenase (NAD+) activity
M8970_RS01740	COG2427	Protein of unknown function (DUF1641)
M8970_RS01745	COG2124	cytochrome p450
M8970_RS01750	COG1819	glycosyl
M8970_RS01760	COG1587	Uroporphyrinogen-III synthase
M8970_RS01765	COG0390	transport system, permease component
M8970_RS01770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8970_RS01775	COG0697	spore germination
M8970_RS01780	COG4297	protein containing double-stranded beta helix domain
M8970_RS01790	COG1252	NADH dehydrogenase
M8970_RS01800	COG2211	Major facilitator Superfamily
M8970_RS01805	COG1609	Transcriptional regulator
M8970_RS01810	COG0246	Mannitol dehydrogenase
M8970_RS01815	COG2721	sulfolactate sulfo-lyase activity
M8970_RS01820	COG0745	RESPONSE REGULATOR receiver
M8970_RS01825	COG2770	Histidine kinase
M8970_RS01825	COG2205	protein histidine kinase activity
M8970_RS01845	COG4585	Histidine kinase
M8970_RS01850	COG2197	response regulator
M8970_RS01885	COG0730	response to heat
M8970_RS01890	COG2318	DinB family
M8970_RS01895	COG0457	Tetratricopeptide repeat
M8970_RS01905	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS01905	COG1388	LysM domain
M8970_RS01905	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8970_RS01915	COG4195	phage-related replication protein
M8970_RS01920	COG2856	Zn peptidase
M8970_RS01925	COG1396	sequence-specific DNA binding
M8970_RS01935	COG1522	sequence-specific DNA binding
M8970_RS01940	COG1484	DNA-dependent DNA replication
M8970_RS01960	COG1595	DNA-templated transcription, initiation
M8970_RS01965	COG3728	DNA packaging
M8970_RS01965	COG5484	DNA packaging
M8970_RS01970	COG1783	phage Terminase large subunit
M8970_RS01975	COG5518	Phage portal protein
M8970_RS01980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M8970_RS01985	COG4653	Phage capsid family
M8970_RS02035	COG3953	SLT domain
M8970_RS02035	COG5412	phage tail tape measure protein
M8970_RS02035	COG5412	phage tail tape measure protein
M8970_RS02035	COG3953	SLT domain
M8970_RS02035	COG5412	phage tail tape measure protein
M8970_RS02035	COG3953	SLT domain
M8970_RS02040	COG1652	LysM domain
M8970_RS02045	COG4193	domain, Protein
M8970_RS02055	COG3628	GPW Gp25 family protein
M8970_RS02060	COG3299	homolog of phage Mu protein gp47
M8970_RS02065	COG3778	Protein conserved in bacteria
M8970_RS02105	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8970_RS02105	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS02125	COG0306	phosphate transporter
M8970_RS02130	COG1392	Phosphate transport regulator
M8970_RS02135	COG0531	amino acid
M8970_RS02140	COG0346	lactoylglutathione lyase activity
M8970_RS02145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8970_RS02150	COG0463	Glycosyl transferase, family 2
M8970_RS02160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8970_RS02165	COG0477	Major facilitator Superfamily
M8970_RS02170	COG2362	D-Aminopeptidase
M8970_RS02175	COG0601	transmembrane transport
M8970_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8970_RS02185	COG0444	Belongs to the ABC transporter superfamily
M8970_RS02190	COG4166	transmembrane transport
M8970_RS02195	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8970_RS02200	COG4948	Mandelate Racemase Muconate Lactonizing
M8970_RS02205	COG0791	NLP P60 protein
M8970_RS02210	COG4608	Belongs to the ABC transporter superfamily
M8970_RS02215	COG2706	6-phosphogluconolactonase activity
M8970_RS02220	COG1834	amidinotransferase
M8970_RS02225	COG1607	acyl-coa hydrolase
M8970_RS02230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8970_RS02235	COG2076	Multidrug Resistance protein
M8970_RS02240	COG2076	Multidrug Resistance protein
M8970_RS02245	COG0788	formyltetrahydrofolate deformylase activity
M8970_RS02250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8970_RS02260	COG1764	response to oxidative stress
M8970_RS02265	COG1846	Transcriptional regulator
M8970_RS02270	COG1764	response to oxidative stress
M8970_RS02285	COG0457	Tetratricopeptide repeat
M8970_RS02285	COG0463	Glycosyl transferase, family 2
M8970_RS02310	COG1404	Belongs to the peptidase S8 family
M8970_RS02315	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS02320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8970_RS02325	COG1122	ATPase activity
M8970_RS02330	COG4721	ABC-type cobalt transport system, permease component
M8970_RS02335	COG3858	chitin binding
M8970_RS02335	COG1388	LysM domain
M8970_RS02345	COG2239	Acts as a magnesium transporter
M8970_RS02350	COG0789	Transcriptional regulator
M8970_RS02365	COG1846	Transcriptional regulator
M8970_RS02370	COG0726	polysaccharide deacetylase
M8970_RS02375	COG1793	dna ligase
M8970_RS02375	COG3285	dna ligase
M8970_RS02380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M8970_RS02390	COG0586	Pfam SNARE associated Golgi protein
M8970_RS02400	COG1191	sigma factor activity
M8970_RS02425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8970_RS02430	COG2323	membrane
M8970_RS02440	COG3594	Acyltransferase
M8970_RS02445	COG5002	protein histidine kinase activity
M8970_RS02450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8970_RS02470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8970_RS02475	COG0436	Aminotransferase
M8970_RS02505	COG3852	Histidine kinase
M8970_RS02510	COG1846	Transcriptional regulator
M8970_RS02515	COG1360	Flagellar Motor Protein
M8970_RS02520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8970_RS02525	COG0542	response to heat
M8970_RS02530	COG3949	Membrane
M8970_RS02545	COG0720	synthase
M8970_RS02550	COG0602	queuosine metabolic process
M8970_RS02565	COG1733	regulation of RNA biosynthetic process
M8970_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS02585	COG4873	Protein conserved in bacteria
M8970_RS02595	COG3773	Cell wall hydrolase
M8970_RS02600	COG2244	polysaccharide biosynthetic process
M8970_RS02605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS02610	COG2217	Heavy metal translocating P-type atpase
M8970_RS02615	COG0006	proline dipeptidase activity
M8970_RS02620	COG1609	Transcriptional regulator
M8970_RS02625	COG3711	transcriptional antiterminator
M8970_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS02630	COG2190	(PTS) system
M8970_RS02630	COG1263	PTS System
M8970_RS02635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS02640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8970_RS02650	COG1533	DNA photolyase activity
M8970_RS02655	COG0840	transmembrane signaling receptor activity
M8970_RS02660	COG2084	Dehydrogenase
M8970_RS02665	COG2340	Cysteine-rich secretory protein family
M8970_RS02670	COG0768	penicillin binding
M8970_RS02675	COG4191	Histidine kinase
M8970_RS02680	COG0436	Aminotransferase
M8970_RS02690	COG0835	chemotaxis
M8970_RS02690	COG0784	Response regulator, receiver
M8970_RS02700	COG2814	Major facilitator Superfamily
M8970_RS02705	COG1376	ErfK ybiS ycfS ynhG family protein
M8970_RS02710	COG1408	metallophosphoesterase
M8970_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS02725	COG2200	EAL domain
M8970_RS02730	COG4703	Protein of unknown function (DUF1797)
M8970_RS02735	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M8970_RS02745	COG0517	IMP dehydrogenase activity
M8970_RS02750	COG0583	DNA-binding transcription factor activity
M8970_RS02755	COG0716	FMN binding
M8970_RS02765	COG0716	FMN binding
M8970_RS02785	COG0668	transmembrane transport
M8970_RS02790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS02810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8970_RS02815	COG0303	'Molybdopterin
M8970_RS02820	COG1763	Mo-molybdopterin cofactor biosynthetic process
M8970_RS02825	COG0314	molybdopterin synthase activity
M8970_RS02830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M8970_RS02840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M8970_RS02845	COG1136	(ABC) transporter
M8970_RS02850	COG0577	efflux transmembrane transporter activity
M8970_RS02855	COG1349	DNA-binding transcription factor activity
M8970_RS02860	COG1105	Belongs to the carbohydrate kinase PfkB family
M8970_RS02865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8970_RS02865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS02865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8970_RS02870	COG0681	Belongs to the peptidase S26 family
M8970_RS02880	COG0488	(ABC) transporter
M8970_RS02885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8970_RS02890	COG2309	aminopeptidase activity
M8970_RS02900	COG1077	Cell shape determining protein MreB Mrl
M8970_RS02905	COG2002	toxin-antitoxin pair type II binding
M8970_RS02910	COG3852	Histidine kinase
M8970_RS02915	COG2105	PFAM AIG2 family protein
M8970_RS02915	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M8970_RS02920	COG0569	domain protein
M8970_RS02930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8970_RS02940	COG0561	phosphatase activity
M8970_RS02945	COG0242	peptide deformylase activity
M8970_RS02955	COG0497	DNA recombination
M8970_RS02960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8970_RS02960	COG2070	2-Nitropropane dioxygenase
M8970_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS02965	COG3321	synthase
M8970_RS02965	COG4221	oxidoreductase activity
M8970_RS02965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS02970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS02970	COG0300	oxidoreductase activity
M8970_RS02970	COG3321	synthase
M8970_RS02970	COG4221	oxidoreductase activity
M8970_RS02975	COG4221	oxidoreductase activity
M8970_RS02975	COG3321	synthase
M8970_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS02975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS02980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS02980	COG0300	oxidoreductase activity
M8970_RS02980	COG3321	synthase
M8970_RS02980	COG4221	oxidoreductase activity
M8970_RS02985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS02985	COG4221	oxidoreductase activity
M8970_RS02985	COG3321	synthase
M8970_RS02985	COG0300	oxidoreductase activity
M8970_RS02990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS02990	COG0300	oxidoreductase activity
M8970_RS02990	COG3321	synthase
M8970_RS02990	COG4221	oxidoreductase activity
M8970_RS02995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS02995	COG3321	synthase
M8970_RS02995	COG4221	oxidoreductase activity
M8970_RS03000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8970_RS03005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8970_RS03010	COG0022	dehydrogenase e1 component
M8970_RS03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8970_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8970_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS03040	COG1982	Orn Lys Arg decarboxylase major
M8970_RS03060	COG0483	inositol monophosphate 1-phosphatase activity
M8970_RS03070	COG3227	Zinc metalloprotease (Elastase)
M8970_RS03075	COG1595	DNA-templated transcription, initiation
M8970_RS03095	COG1217	gtp-binding protein TYPA
M8970_RS03105	COG4896	Protein conserved in bacteria
M8970_RS03115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M8970_RS03120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8970_RS03125	COG2066	Belongs to the glutaminase family
M8970_RS03135	COG0772	Belongs to the SEDS family
M8970_RS03140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M8970_RS03155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8970_RS03155	COG2010	Cytochrome c
M8970_RS03160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8970_RS03165	COG1845	cytochrome c oxidase, subunit III
M8970_RS03170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M8970_RS03175	COG3336	cytochrome c oxidase
M8970_RS03185	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M8970_RS03190	COG2340	Cysteine-rich secretory protein family
M8970_RS03205	COG3679	Belongs to the UPF0342 family
M8970_RS03215	COG0742	ribosomal rna small subunit methyltransferase
M8970_RS03225	COG3314	Sporulation integral membrane protein YlbJ
M8970_RS03230	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8970_RS03235	COG3480	Lon protease (S16) C-terminal proteolytic domain
M8970_RS03245	COG1399	metal-binding, possibly nucleic acid-binding protein
M8970_RS03265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8970_RS03285	COG4839	cell division protein FtsL
M8970_RS03290	COG0768	penicillin binding
M8970_RS03295	COG0768	penicillin binding
M8970_RS03315	COG0772	Belongs to the SEDS family
M8970_RS03330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M8970_RS03335	COG0849	cell division
M8970_RS03340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M8970_RS03345	COG4412	M6 family metalloprotease domain protein
M8970_RS03345	COG1404	Belongs to the peptidase S8 family
M8970_RS03355	COG1191	sigma factor activity
M8970_RS03360	COG1191	sigma factor activity
M8970_RS03365	COG1119	ATPase activity
M8970_RS03370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8970_RS03375	COG1873	PFAM PRC-barrel domain
M8970_RS03380	COG1496	oxidoreductase activity
M8970_RS03385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M8970_RS03395	COG0762	integral membrane protein
M8970_RS03400	COG2302	S4 RNA-binding domain
M8970_RS03405	COG3599	regulation of cell shape
M8970_RS03410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M8970_RS03415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8970_RS03425	COG0564	pseudouridine synthase activity
M8970_RS03435	COG2233	PERMEase
M8970_RS03445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M8970_RS03450	COG0505	Belongs to the CarA family
M8970_RS03455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8970_RS03470	COG0284	orotidine-5'-phosphate decarboxylase activity
M8970_RS03475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M8970_RS03485	COG0306	phosphate transporter
M8970_RS03500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8970_RS03505	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M8970_RS03510	COG1648	precorrin-2 dehydrogenase activity
M8970_RS03520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M8970_RS03525	COG1561	YicC-like family, N-terminal region
M8970_RS03535	COG0194	GDP metabolic process
M8970_RS03545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8970_RS03550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8970_RS03555	COG0242	peptide deformylase activity
M8970_RS03565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8970_RS03565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M8970_RS03575	COG0631	protein serine/threonine phosphatase activity
M8970_RS03580	COG0515	serine threonine protein kinase
M8970_RS03580	COG2815	serine threonine protein kinase
M8970_RS03590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M8970_RS03595	COG1564	THIamine pyrophosphokinase
M8970_RS03610	COG1302	Protein conserved in bacteria
M8970_RS03615	COG1461	Dihydroxyacetone kinase
M8970_RS03620	COG1760	l-serine dehydratase
M8970_RS03625	COG1760	l-serine dehydratase
M8970_RS03630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M8970_RS03645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8970_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS03665	COG1196	nuclear chromosome segregation
M8970_RS03670	COG0552	protein localization to endoplasmic reticulum
M8970_RS03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M8970_RS03695	COG1837	Belongs to the UPF0109 family
M8970_RS03720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8970_RS03735	COG2257	FlhB HrpN YscU SpaS Family
M8970_RS03745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M8970_RS03750	COG0758	DNA mediated transformation
M8970_RS03755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8970_RS03765	COG4974	Belongs to the 'phage' integrase family
M8970_RS03785	COG1815	bacterial-type flagellum-dependent cell motility
M8970_RS03790	COG1558	bacterial-type flagellum-dependent cell motility
M8970_RS03795	COG1677	Flagellar hook-basal body complex protein FliE
M8970_RS03800	COG1766	The M ring may be actively involved in energy transduction
M8970_RS03805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8970_RS03810	COG1317	bacterial-type flagellum organization
M8970_RS03815	COG1157	protein secretion by the type III secretion system
M8970_RS03820	COG2882	bacterial-type flagellum organization
M8970_RS03825	COG3334	PFAM MgtE intracellular
M8970_RS03830	COG3144	bacterial-type flagellum assembly
M8970_RS03835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M8970_RS03840	COG4786	Flagellar basal body rod
M8970_RS03845	COG1582	Flagellar protein (FlbD)
M8970_RS03850	COG1580	Controls the rotational direction of flagella during chemotaxis
M8970_RS03855	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8970_RS03860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8970_RS03860	COG1776	CheC inhibitor of MCP methylation
M8970_RS03865	COG2201	protein-glutamate methylesterase activity
M8970_RS03870	COG3190	flagellar
M8970_RS03875	COG1338	Plays a role in the flagellum-specific transport system
M8970_RS03880	COG1987	bacterial-type flagellum assembly
M8970_RS03885	COG1684	flagellar biosynthetic protein fliR
M8970_RS03890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8970_RS03895	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8970_RS03900	COG1419	protein localization to endoplasmic reticulum
M8970_RS03905	COG0455	bacterial-type flagellum organization
M8970_RS03910	COG2201	protein-glutamate methylesterase activity
M8970_RS03915	COG2198	Histidine kinase
M8970_RS03915	COG0643	Histidine kinase
M8970_RS03920	COG0835	chemotaxis
M8970_RS03925	COG1776	CheC inhibitor of MCP methylation
M8970_RS03935	COG1191	sigma factor activity
M8970_RS03965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M8970_RS03970	COG4589	Belongs to the CDS family
M8970_RS03980	COG0750	zinc metalloprotease
M8970_RS04000	COG0195	Participates in both transcription termination and antitermination
M8970_RS04005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M8970_RS04010	COG1358	cellular component organization or biogenesis
M8970_RS04020	COG1550	Protein conserved in bacteria
M8970_RS04035	COG0196	riboflavin kinase activity
M8970_RS04050	COG0726	polysaccharide deacetylase
M8970_RS04055	COG0612	Peptidase, M16
M8970_RS04060	COG1873	PFAM PRC-barrel domain
M8970_RS04065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8970_RS04070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8970_RS04075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M8970_RS04080	COG0527	aspartate kinase activity
M8970_RS04090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8970_RS04095	COG0740	serine-type endopeptidase activity
M8970_RS04105	COG1674	ftsk spoiiie
M8970_RS04105	COG4980	gas vesicle protein
M8970_RS04110	COG2188	Transcriptional regulator
M8970_RS04115	COG2814	Major facilitator Superfamily
M8970_RS04120	COG1846	Transcriptional regulator
M8970_RS04125	COG1033	growth of symbiont in host cell
M8970_RS04125	COG2409	Drug exporters of the RND superfamily
M8970_RS04130	COG0612	Peptidase, M16
M8970_RS04135	COG0612	Peptidase, M16
M8970_RS04140	COG0300	oxidoreductase activity
M8970_RS04155	COG1426	Protein conserved in bacteria
M8970_RS04160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M8970_RS04175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8970_RS04185	COG1692	metallophosphoesterase
M8970_RS04190	COG2359	stage V sporulation protein S
M8970_RS04210	COG4550	Control of competence regulator ComK, YlbF/YmcA
M8970_RS04255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS04260	COG3425	synthase
M8970_RS04265	COG1024	Enoyl-CoA hydratase
M8970_RS04270	COG1024	Enoyl-CoA hydratase
M8970_RS04275	COG3321	synthase
M8970_RS04275	COG0300	oxidoreductase activity
M8970_RS04275	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS04280	COG4221	oxidoreductase activity
M8970_RS04280	COG3321	synthase
M8970_RS04280	COG0300	oxidoreductase activity
M8970_RS04285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS04285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS04285	COG3321	synthase
M8970_RS04285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04285	COG3321	synthase
M8970_RS04285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS04285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04290	COG3321	synthase
M8970_RS04290	COG4221	oxidoreductase activity
M8970_RS04290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS04295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M8970_RS04295	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8970_RS04295	COG3321	synthase
M8970_RS04295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS04300	COG2124	cytochrome p450
M8970_RS04305	COG3209	COG3209 Rhs family protein
M8970_RS04310	COG3619	membrane
M8970_RS04320	COG1404	Belongs to the peptidase S8 family
M8970_RS04330	COG4195	phage-related replication protein
M8970_RS04335	COG1764	response to oxidative stress
M8970_RS04345	COG2076	Multidrug Resistance protein
M8970_RS04385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8970_RS04390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8970_RS04395	COG4112	unkown
M8970_RS04400	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS04405	COG0464	growth
M8970_RS04410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M8970_RS04415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M8970_RS04420	COG0789	Transcriptional regulator
M8970_RS04425	COG0174	glutamine synthetase
M8970_RS04470	COG2211	Major facilitator Superfamily
M8970_RS04475	COG3507	Belongs to the glycosyl hydrolase 43 family
M8970_RS04490	COG1070	Carbohydrate kinase
M8970_RS04495	COG3848	Pyruvate phosphate dikinase
M8970_RS04495	COG0574	Belongs to the PEP-utilizing enzyme family
M8970_RS04515	COG2318	DinB family
M8970_RS04520	COG1064	alcohol dehydrogenase
M8970_RS04525	COG4451	ribulose bisphosphate carboxylase, small
M8970_RS04525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8970_RS04570	COG3397	chitin binding
M8970_RS04590	COG5434	Belongs to the glycosyl hydrolase 28 family
M8970_RS04595	COG0756	dUTP diphosphatase activity
M8970_RS04605	COG4195	phage-related replication protein
M8970_RS04640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M8970_RS04650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M8970_RS04670	COG0785	Cytochrome C biogenesis protein
M8970_RS04675	COG2201	protein-glutamate methylesterase activity
M8970_RS04680	COG4846	Membrane protein involved in cytochrome C biogenesis
M8970_RS04690	COG0071	Belongs to the small heat shock protein (HSP20) family
M8970_RS04705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M8970_RS04710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS04730	COG0824	Thioesterase
M8970_RS04740	COG4841	protein insertion into membrane
M8970_RS04750	COG1832	CoA-binding protein
M8970_RS04755	COG0187	DNA topoisomerase II activity
M8970_RS04760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8970_RS04770	COG1115	amino acid carrier protein
M8970_RS04780	COG1063	alcohol dehydrogenase
M8970_RS04785	COG0800	Aldolase
M8970_RS04790	COG1312	Catalyzes the dehydration of D-mannonate
M8970_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04800	COG1609	Transcriptional regulator
M8970_RS04805	COG2271	Major facilitator Superfamily
M8970_RS04855	COG2205	protein histidine kinase activity
M8970_RS04860	COG0745	RESPONSE REGULATOR receiver
M8970_RS04870	COG3507	Belongs to the glycosyl hydrolase 43 family
M8970_RS04895	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS04900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8970_RS04905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8970_RS04910	COG2610	gluconate transmembrane transporter activity
M8970_RS04915	COG2124	cytochrome p450
M8970_RS04935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8970_RS04945	COG2246	polysaccharide biosynthetic process
M8970_RS04955	COG0586	Pfam SNARE associated Golgi protein
M8970_RS04960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8970_RS04965	COG1024	Enoyl-CoA hydratase
M8970_RS04970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M8970_RS04975	COG0511	ligase activity, forming carbon-carbon bonds
M8970_RS04980	COG0439	Biotin carboxylase
M8970_RS04985	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS04990	COG1960	acyl-CoA dehydrogenase activity
M8970_RS04995	COG1649	PFAM Uncharacterised BCR, COG1649
M8970_RS05005	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8970_RS05005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS05010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS05015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS05020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS05025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS05030	COG2027	D-alanyl-D-alanine carboxypeptidase
M8970_RS05035	COG2017	converts alpha-aldose to the beta-anomer
M8970_RS05040	COG0534	Mate efflux family protein
M8970_RS05055	COG0582	viral genome integration into host DNA
M8970_RS05060	COG0166	Belongs to the GPI family
M8970_RS05065	COG0405	Gamma-glutamyltransferase
M8970_RS05070	COG2814	Major facilitator Superfamily
M8970_RS05075	COG0640	Transcriptional regulator
M8970_RS05080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M8970_RS05090	COG0604	alcohol dehydrogenase
M8970_RS05095	COG0493	'glutamate synthase
M8970_RS05100	COG0067	glutamate synthase
M8970_RS05100	COG0069	glutamate synthase activity
M8970_RS05100	COG0070	glutamate synthase
M8970_RS05105	COG0583	DNA-binding transcription factor activity
M8970_RS05110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8970_RS05125	COG0300	oxidoreductase activity
M8970_RS05130	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8970_RS05140	COG2814	Major facilitator Superfamily
M8970_RS05145	COG1070	Carbohydrate kinase
M8970_RS05150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8970_RS05155	COG0243	molybdopterin cofactor binding
M8970_RS05185	COG5444	nuclease activity
M8970_RS05190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8970_RS05195	COG0662	Cupin 2, conserved barrel domain protein
M8970_RS05195	COG2207	Transcriptional regulator
M8970_RS05200	COG1309	transcriptional regulator
M8970_RS05205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS05215	COG0640	Transcriptional regulator
M8970_RS05220	COG0741	lytic transglycosylase activity
M8970_RS05225	COG2322	membrane
M8970_RS05240	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8970_RS05250	COG1388	LysM domain
M8970_RS05250	COG3584	3D domain protein
M8970_RS05255	COG0514	ATP-dependent DNA helicase (RecQ)
M8970_RS05265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M8970_RS05270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8970_RS05285	COG0071	Belongs to the small heat shock protein (HSP20) family
M8970_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS05320	COG1657	PFAM Prenyltransferase squalene oxidase
M8970_RS05325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8970_RS05330	COG0733	neurotransmitter:sodium symporter activity
M8970_RS05335	COG0385	Bile acid
M8970_RS05340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS05345	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8970_RS05355	COG4548	von Willebrand factor, type A
M8970_RS05360	COG0714	Associated with various cellular activities
M8970_RS05365	COG2032	superoxide dismutase activity
M8970_RS05370	COG1388	LysM domain
M8970_RS05370	COG0791	NLP P60 protein
M8970_RS05375	COG1819	glycosyl
M8970_RS05380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8970_RS05385	COG0534	Mate efflux family protein
M8970_RS05390	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS05395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8970_RS05400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8970_RS05410	COG2962	Rard protein
M8970_RS05425	COG1942	4-Oxalocrotonate Tautomerase
M8970_RS05435	COG1733	regulation of RNA biosynthetic process
M8970_RS05440	COG0778	Nitroreductase
M8970_RS05445	COG0400	carboxylic ester hydrolase activity
M8970_RS05450	COG0346	lactoylglutathione lyase activity
M8970_RS05460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8970_RS05470	COG2723	6-phospho-beta-galactosidase activity
M8970_RS05475	COG2188	Transcriptional regulator
M8970_RS05480	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS05480	COG0793	Belongs to the peptidase S41A family
M8970_RS05485	COG2226	methyltransferase
M8970_RS05495	COG1876	peptidase activity
M8970_RS05515	COG0671	phosphoesterase, PA-phosphatase related
M8970_RS05545	COG1509	lysine 2,3-aminomutase activity
M8970_RS05550	COG0456	acetyltransferase
M8970_RS05555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8970_RS05560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8970_RS05565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8970_RS05570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8970_RS05575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M8970_RS05585	COG0456	acetyltransferase
M8970_RS05590	COG0463	Glycosyl transferase, family 2
M8970_RS05605	COG4641	Protein conserved in bacteria
M8970_RS05615	COG1086	Polysaccharide biosynthesis protein
M8970_RS05650	COG0457	Tetratricopeptide repeat
M8970_RS05660	COG3391	amine dehydrogenase activity
M8970_RS05680	COG5444	nuclease activity
M8970_RS05685	COG4282	regulation of fungal-type cell wall biogenesis
M8970_RS05690	COG1525	nuclease
M8970_RS05715	COG1846	Transcriptional regulator
M8970_RS05720	COG4698	Protein conserved in bacteria
M8970_RS05725	COG2755	lipolytic protein G-D-S-L family
M8970_RS05730	COG1999	signal sequence binding
M8970_RS05740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8970_RS05745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M8970_RS05750	COG1272	protein, Hemolysin III
M8970_RS05755	COG0204	Acyl-transferase
M8970_RS05760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8970_RS05775	COG2136	Putative SAM-dependent methyltransferase
M8970_RS05775	COG2521	methyltransferase
M8970_RS05790	COG1413	lyase activity
M8970_RS05795	COG1418	mRNA catabolic process
M8970_RS05800	COG0386	Belongs to the glutathione peroxidase family
M8970_RS05810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8970_RS05820	COG1278	Cold shock
M8970_RS05840	COG0328	RNA-DNA hybrid ribonuclease activity
M8970_RS05845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M8970_RS05850	COG0328	RNA-DNA hybrid ribonuclease activity
M8970_RS05860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8970_RS05875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8970_RS05885	COG1755	Isoprenylcysteine carboxyl methyltransferase
M8970_RS05890	COG3424	synthase
M8970_RS05915	COG1335	isochorismatase
M8970_RS05925	COG2233	PERMEase
M8970_RS05935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M8970_RS05940	COG1199	ATP-dependent helicase activity
M8970_RS05955	COG0116	Belongs to the methyltransferase superfamily
M8970_RS05985	COG3359	exonuclease
M8970_RS05990	COG1111	helicase
M8970_RS05990	COG1205	dead DEAH box helicase
M8970_RS05995	COG2190	(PTS) system
M8970_RS06000	COG0071	Belongs to the small heat shock protein (HSP20) family
M8970_RS06040	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8970_RS06040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8970_RS06050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8970_RS06055	COG3935	DnaD domain protein
M8970_RS06065	COG0436	Aminotransferase
M8970_RS06070	COG5353	protein conserved in bacteria
M8970_RS06080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M8970_RS06080	COG1199	ATP-dependent helicase activity
M8970_RS06110	COG0438	transferase activity, transferring glycosyl groups
M8970_RS06115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8970_RS06130	COG1694	Mazg nucleotide pyrophosphohydrolase
M8970_RS06135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS06150	COG4347	Protein of unknown function (DUF1405)
M8970_RS06155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8970_RS06155	COG2010	Cytochrome c
M8970_RS06160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8970_RS06165	COG0723	plastoquinol--plastocyanin reductase activity
M8970_RS06180	COG0457	Tetratricopeptide repeat
M8970_RS06190	COG0287	Prephenate dehydrogenase
M8970_RS06225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8970_RS06230	COG4401	Chorismate mutase type I
M8970_RS06245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M8970_RS06250	COG0105	UTP biosynthetic process
M8970_RS06255	COG0142	geranyltranstransferase activity
M8970_RS06265	COG0142	geranyltranstransferase activity
M8970_RS06280	COG0776	regulation of translation
M8970_RS06285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8970_RS06325	COG0539	negative regulation of cytoplasmic translation
M8970_RS06340	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M8970_RS06345	COG2959	enzyme of heme biosynthesis
M8970_RS06350	COG3773	Cell wall hydrolase
M8970_RS06350	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS06355	COG2339	peptidase activity
M8970_RS06360	COG0492	ferredoxin-NADP+ reductase activity
M8970_RS06365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8970_RS06370	COG4862	establishment of competence for transformation
M8970_RS06375	COG1408	metallophosphoesterase
M8970_RS06385	COG1388	LysM domain
M8970_RS06390	COG1266	CAAX protease self-immunity
M8970_RS06395	COG0514	ATP-dependent DNA helicase (RecQ)
M8970_RS06400	COG4955	Helix-turn-helix domain
M8970_RS06405	COG1141	Ferredoxin
M8970_RS06410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M8970_RS06415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8970_RS06425	COG1595	DNA-templated transcription, initiation
M8970_RS06430	COG5002	protein histidine kinase activity
M8970_RS06435	COG0745	RESPONSE REGULATOR receiver
M8970_RS06440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8970_RS06445	COG1333	cytochrome c biogenesis protein
M8970_RS06450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS06455	COG1187	pseudouridine synthase activity
M8970_RS06460	COG0700	Nucleoside recognition
M8970_RS06465	COG2715	membrane protein required for spore maturation
M8970_RS06470	COG1686	Belongs to the peptidase S11 family
M8970_RS06495	COG1547	Domain of unknown function (DUF309)
M8970_RS06500	COG0456	acetyltransferase
M8970_RS06515	COG0307	riboflavin synthase, alpha
M8970_RS06520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8970_RS06520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8970_RS06530	COG0681	Belongs to the peptidase S26 family
M8970_RS06540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M8970_RS06545	COG4086	secreted protein
M8970_RS06550	COG0019	diaminopimelate decarboxylase activity
M8970_RS06555	COG0697	spore germination
M8970_RS06570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8970_RS06590	COG1191	sigma factor activity
M8970_RS06600	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS06605	COG1686	Belongs to the peptidase S11 family
M8970_RS06610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M8970_RS06615	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M8970_RS06620	COG4974	Belongs to the 'phage' integrase family
M8970_RS06630	COG0735	belongs to the Fur family
M8970_RS06635	COG1300	Membrane
M8970_RS06650	COG0281	malic enzyme
M8970_RS06655	COG1757	Na H antiporter
M8970_RS06660	COG1027	Aspartate ammonia-lyase
M8970_RS06665	COG0252	asparaginase activity
M8970_RS06670	COG1396	sequence-specific DNA binding
M8970_RS06675	COG1379	DNA repair
M8970_RS06680	COG0494	nUDIX hydrolase
M8970_RS06690	COG0667	Aldo Keto reductase
M8970_RS06700	COG1073	alpha beta
M8970_RS06710	COG4918	Iron-sulphur cluster biosynthesis
M8970_RS06715	COG0456	acetyltransferase
M8970_RS06715	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M8970_RS06720	COG2329	Antibiotic biosynthesis monooxygenase
M8970_RS06725	COG0456	acetyltransferase
M8970_RS06730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8970_RS06745	COG0628	permease
M8970_RS06755	COG0346	lactoylglutathione lyase activity
M8970_RS06765	COG3048	D-serine ammonia-lyase activity
M8970_RS06770	COG0300	oxidoreductase activity
M8970_RS06775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS06780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8970_RS06785	COG1024	Enoyl-CoA hydratase
M8970_RS06790	COG3425	synthase
M8970_RS06795	COG2124	cytochrome p450
M8970_RS06800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS06800	COG3321	synthase
M8970_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS06805	COG3321	synthase
M8970_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS06805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS06805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06810	COG0300	oxidoreductase activity
M8970_RS06810	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS06810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06810	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06810	COG3321	synthase
M8970_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06815	COG0300	oxidoreductase activity
M8970_RS06815	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS06815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06815	COG3321	synthase
M8970_RS06820	COG3321	synthase
M8970_RS06820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS06820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06825	COG3321	synthase
M8970_RS06825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06825	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS06825	COG0300	oxidoreductase activity
M8970_RS06830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8970_RS06830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06830	COG3321	synthase
M8970_RS06830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS06840	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS06855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8970_RS06855	COG2070	2-Nitropropane dioxygenase
M8970_RS06860	COG0250	Participates in transcription elongation, termination and antitermination
M8970_RS06880	COG0596	Alpha beta hydrolase
M8970_RS06895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M8970_RS06900	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M8970_RS06915	COG0706	membrane insertase activity
M8970_RS06920	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8970_RS06925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8970_RS06930	COG0346	lactoylglutathione lyase activity
M8970_RS06945	COG4129	membrane
M8970_RS06950	COG1126	abc transporter atp-binding protein
M8970_RS06955	COG0765	amino acid transport
M8970_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8970_RS06970	COG1597	lipid kinase activity
M8970_RS06975	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8970_RS06980	COG0022	dehydrogenase e1 component
M8970_RS06985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8970_RS06990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8970_RS06995	COG3426	butyrate kinase activity
M8970_RS07000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8970_RS07005	COG0280	phosphate acetyltransferase
M8970_RS07010	COG3829	transcription factor binding
M8970_RS07010	COG3290	protein histidine kinase activity
M8970_RS07020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M8970_RS07025	COG2079	MmgE PrpD family protein
M8970_RS07030	COG0372	Belongs to the citrate synthase family
M8970_RS07035	COG1960	acyl-CoA dehydrogenase activity
M8970_RS07040	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8970_RS07045	COG0183	Belongs to the thiolase family
M8970_RS07050	COG0584	glycerophosphoryl diester phosphodiesterase
M8970_RS07055	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS07080	COG1902	pentaerythritol trinitrate reductase activity
M8970_RS07095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8970_RS07100	COG0745	RESPONSE REGULATOR receiver
M8970_RS07105	COG0750	zinc metalloprotease
M8970_RS07110	COG0497	DNA recombination
M8970_RS07120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M8970_RS07130	COG0142	geranyltranstransferase activity
M8970_RS07140	COG1570	exodeoxyribonuclease VII activity
M8970_RS07155	COG1302	Protein conserved in bacteria
M8970_RS07160	COG0439	Biotin carboxylase
M8970_RS07165	COG0511	ligase activity, forming carbon-carbon bonds
M8970_RS07205	COG3854	ATPases associated with a variety of cellular activities
M8970_RS07220	COG0006	proline dipeptidase activity
M8970_RS07230	COG3872	metal-dependent enzyme
M8970_RS07240	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8970_RS07255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8970_RS07275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8970_RS07290	COG1396	sequence-specific DNA binding
M8970_RS07300	COG0681	Belongs to the peptidase S26 family
M8970_RS07325	COG4940	Competence protein ComGF
M8970_RS07335	COG4970	Tfp pilus assembly protein FimT
M8970_RS07340	COG4537	Required for transformation and DNA binding
M8970_RS07345	COG1459	type II secretion system
M8970_RS07350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M8970_RS07355	COG0598	Magnesium transport protein CorA
M8970_RS07360	COG1253	flavin adenine dinucleotide binding
M8970_RS07365	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS07375	COG1393	Belongs to the ArsC family
M8970_RS07385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS07395	COG0011	TIGRFAM Protein of
M8970_RS07405	COG2866	Carboxypeptidase
M8970_RS07410	COG1940	carbohydrate kinase activity
M8970_RS07415	COG4483	Protein conserved in bacteria
M8970_RS07420	COG1757	Na H antiporter
M8970_RS07430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M8970_RS07445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8970_RS07450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8970_RS07455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8970_RS07460	COG0581	inorganic phosphate transmembrane transporter activity
M8970_RS07465	COG0573	inorganic phosphate transmembrane transporter activity
M8970_RS07470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M8970_RS07475	COG0768	penicillin binding
M8970_RS07480	COG0477	Major facilitator Superfamily
M8970_RS07485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8970_RS07490	COG2839	Protein conserved in bacteria
M8970_RS07495	COG5521	maltodextrose utilization protein MalA
M8970_RS07500	COG1388	LysM domain
M8970_RS07510	COG4709	membrane
M8970_RS07515	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M8970_RS07520	COG0735	belongs to the Fur family
M8970_RS07525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS07540	COG0513	Belongs to the DEAD box helicase family
M8970_RS07555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M8970_RS07560	COG2384	SAM-dependent methyltransferase
M8970_RS07565	COG2010	Cytochrome c
M8970_RS07570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M8970_RS07575	COG0358	DNA primase activity
M8970_RS07590	COG0517	IMP dehydrogenase activity
M8970_RS07595	COG0751	glycine-tRNA ligase activity
M8970_RS07615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M8970_RS07620	COG0295	cytidine deaminase activity
M8970_RS07625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M8970_RS07635	COG1480	7TM receptor with intracellular HD hydrolase
M8970_RS07640	COG1702	phosphate starvation-inducible protein PhoH
M8970_RS07645	COG0561	phosphatase activity
M8970_RS07660	COG4864	UPF0365 protein
M8970_RS07665	COG1030	water channel activity
M8970_RS07670	COG1610	YqeY-like protein
M8970_RS07680	COG1283	sodium-dependent phosphate transmembrane transporter activity
M8970_RS07685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8970_RS07690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M8970_RS07720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8970_RS07735	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS07765	COG0658	competence protein
M8970_RS07765	COG2333	competence protein COMEC
M8970_RS07770	COG2131	deaminase
M8970_RS07775	COG1596	polysaccharide export
M8970_RS07775	COG1555	photosystem II stabilization
M8970_RS07780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8970_RS07785	COG2226	methyltransferase
M8970_RS07790	COG0799	negative regulation of ribosome biogenesis
M8970_RS07795	COG1713	HD superfamily hydrolase involved in NAD metabolism
M8970_RS07805	COG1534	Rna-binding protein
M8970_RS07810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M8970_RS07815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8970_RS07820	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M8970_RS07830	COG2755	lipolytic protein G-D-S-L family
M8970_RS07840	COG0398	Pfam SNARE associated Golgi protein
M8970_RS07865	COG1794	racemase activity, acting on amino acids and derivatives
M8970_RS07885	COG0656	L-ascorbic acid biosynthetic process
M8970_RS07915	COG3677	Transposase
M8970_RS07955	COG5002	protein histidine kinase activity
M8970_RS07955	COG0642	Histidine kinase
M8970_RS07960	COG0745	RESPONSE REGULATOR receiver
M8970_RS07965	COG2311	Membrane
M8970_RS07975	COG0454	-acetyltransferase
M8970_RS07980	COG0563	adenylate kinase activity
M8970_RS07990	COG2814	Major facilitator Superfamily
M8970_RS07995	COG0456	acetyltransferase
M8970_RS08000	COG2318	DinB family
M8970_RS08010	COG0561	phosphatase activity
M8970_RS08015	COG0561	phosphatase activity
M8970_RS08025	COG1482	cell wall glycoprotein biosynthetic process
M8970_RS08030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8970_RS08030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS08030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8970_RS08035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS08035	COG3711	transcriptional antiterminator
M8970_RS08045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M8970_RS08050	COG0583	DNA-binding transcription factor activity
M8970_RS08055	COG2814	Major facilitator Superfamily
M8970_RS08060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8970_RS08060	COG2124	cytochrome p450
M8970_RS08065	COG1309	transcriptional regulator
M8970_RS08070	COG2226	methyltransferase
M8970_RS08085	COG2116	formate transmembrane transporter activity
M8970_RS08090	COG5609	conserved protein (DUF2294)
M8970_RS08095	COG3383	formate dehydrogenase (NAD+) activity
M8970_RS08100	COG2427	Protein of unknown function (DUF1641)
M8970_RS08110	COG0626	cystathionine gamma-synthase activity
M8970_RS08115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8970_RS08140	COG0768	penicillin binding
M8970_RS08155	COG0826	peptidase U32
M8970_RS08160	COG0826	peptidase U32
M8970_RS08165	COG4122	O-methyltransferase activity
M8970_RS08170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8970_RS08195	COG0628	permease
M8970_RS08200	COG1126	abc transporter atp-binding protein
M8970_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8970_RS08210	COG0765	amino acid transport
M8970_RS08215	COG0765	amino acid transport
M8970_RS08230	COG3881	PFAM PRC-barrel domain
M8970_RS08235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M8970_RS08240	COG0457	Tetratricopeptide repeat
M8970_RS08250	COG1104	cysteine desulfurase activity
M8970_RS08255	COG1959	2 iron, 2 sulfur cluster binding
M8970_RS08260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8970_RS08265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M8970_RS08290	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS08290	COG3103	Sh3 type 3 domain protein
M8970_RS08290	COG4991	sh3 domain protein
M8970_RS08300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M8970_RS08310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M8970_RS08310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M8970_RS08315	COG5416	Lipopolysaccharide assembly protein A domain
M8970_RS08320	COG0490	domain, Protein
M8970_RS08325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8970_RS08325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8970_RS08335	COG2244	polysaccharide biosynthetic process
M8970_RS08340	COG2323	membrane
M8970_RS08350	COG1862	Preprotein translocase
M8970_RS08390	COG1388	LysM domain
M8970_RS08400	COG0157	Belongs to the NadC ModD family
M8970_RS08405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M8970_RS08410	COG1104	cysteine desulfurase activity
M8970_RS08415	COG1827	regulation of RNA biosynthetic process
M8970_RS08420	COG0077	Prephenate dehydratase
M8970_RS08435	COG3290	protein histidine kinase activity
M8970_RS08440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M8970_RS08445	COG2868	ribosomal protein
M8970_RS08455	COG1994	Peptidase M50
M8970_RS08460	COG0739	heme binding
M8970_RS08465	COG2894	cell division
M8970_RS08470	COG0850	regulation of cytokinetic process
M8970_RS08475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M8970_RS08485	COG1077	Cell shape determining protein MreB Mrl
M8970_RS08505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M8970_RS08510	COG0285	dihydrofolate synthase activity
M8970_RS08515	COG0525	valine-tRNA ligase activity
M8970_RS08525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8970_RS08530	COG1388	LysM domain
M8970_RS08540	COG0113	porphobilinogen synthase activity
M8970_RS08545	COG1587	Uroporphyrinogen-III synthase
M8970_RS08555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8970_RS08575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M8970_RS08580	COG0470	DNA polymerase III
M8970_RS08580	COG1067	ATP-dependent peptidase activity
M8970_RS08595	COG0457	Tetratricopeptide repeat
M8970_RS08595	COG1477	protein flavinylation
M8970_RS08610	COG0473	3-isopropylmalate dehydrogenase activity
M8970_RS08625	COG0440	acetolactate synthase activity
M8970_RS08630	COG0028	Belongs to the TPP enzyme family
M8970_RS08655	COG0622	Phosphoesterase
M8970_RS08660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M8970_RS08670	COG5401	PFAM Sporulation and spore germination
M8970_RS08680	COG1846	Transcriptional regulator
M8970_RS08685	COG2197	response regulator
M8970_RS08690	COG0824	Thioesterase
M8970_RS08695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M8970_RS08700	COG1053	succinate dehydrogenase
M8970_RS08705	COG2009	succinate dehydrogenase
M8970_RS08710	COG1719	4-vinyl reductase, 4VR
M8970_RS08715	COG0527	aspartate kinase activity
M8970_RS08725	COG3118	belongs to the thioredoxin family
M8970_RS08730	COG3534	alpha-L-arabinofuranosidase
M8970_RS08735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M8970_RS08740	COG2086	electron transfer activity
M8970_RS08745	COG1024	Enoyl-CoA hydratase
M8970_RS08750	COG1309	transcriptional regulator
M8970_RS08755	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS08765	COG3766	membrane
M8970_RS08775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8970_RS08775	COG1796	DNA polymerase
M8970_RS08780	COG1286	toxin biosynthetic process
M8970_RS08795	COG0072	phenylalanine-tRNA ligase activity
M8970_RS08795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8970_RS08800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M8970_RS08805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8970_RS08815	COG3835	regulator
M8970_RS08820	COG0277	FAD linked oxidase domain protein
M8970_RS08825	COG0247	lactate metabolic process
M8970_RS08830	COG1966	Carbon starvation protein
M8970_RS08835	COG3534	alpha-L-arabinofuranosidase
M8970_RS08840	COG0395	ABC-type sugar transport system, permease component
M8970_RS08845	COG1175	transmembrane transport
M8970_RS08850	COG1653	transport
M8970_RS08860	COG0647	UMP catabolic process
M8970_RS08865	COG0235	Class ii aldolase
M8970_RS08870	COG1069	ribulokinase activity
M8970_RS08875	COG2160	L-arabinose isomerase activity
M8970_RS08880	COG3507	Belongs to the glycosyl hydrolase 43 family
M8970_RS08885	COG1363	Peptidase, m42
M8970_RS08895	COG3326	Membrane
M8970_RS08910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M8970_RS08915	COG1346	cytolysis
M8970_RS08920	COG1380	Effector of murein hydrolase LrgA
M8970_RS08925	COG3279	Response regulator of the LytR AlgR family
M8970_RS08930	COG3275	phosphorelay sensor kinase activity
M8970_RS08935	COG1011	Hydrolase
M8970_RS08950	COG0398	Pfam SNARE associated Golgi protein
M8970_RS08955	COG1484	DNA-dependent DNA replication
M8970_RS08960	COG3611	Membrane attachment protein
M8970_RS08975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8970_RS08980	COG1733	regulation of RNA biosynthetic process
M8970_RS08985	COG2814	Major facilitator Superfamily
M8970_RS08990	COG0656	L-ascorbic acid biosynthetic process
M8970_RS08995	COG0237	dephospho-CoA kinase activity
M8970_RS09000	COG1971	Probably functions as a manganese efflux pump
M8970_RS09005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M8970_RS09010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8970_RS09010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8970_RS09015	COG5002	protein histidine kinase activity
M8970_RS09020	COG0745	RESPONSE REGULATOR receiver
M8970_RS09030	COG0538	isocitrate dehydrogenase activity
M8970_RS09035	COG0372	Belongs to the citrate synthase family
M8970_RS09065	COG0628	permease
M8970_RS09070	COG3030	protein affecting phage T7 exclusion by the F plasmid
M8970_RS09075	COG0469	pyruvate kinase activity
M8970_RS09095	COG0281	malic enzyme
M8970_RS09100	COG0587	DNA-directed DNA polymerase activity
M8970_RS09120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M8970_RS09130	COG4109	DRTGG domain
M8970_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS09155	COG0521	Mo-molybdopterin cofactor biosynthetic process
M8970_RS09165	COG0827	DNA restriction-modification system
M8970_RS09170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M8970_RS09175	COG3874	Sporulation protein YtfJ
M8970_RS09185	COG1714	RDD family
M8970_RS09190	COG0616	signal peptide processing
M8970_RS09195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8970_RS09200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M8970_RS09205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8970_RS09220	COG1104	cysteine desulfurase activity
M8970_RS09225	COG1114	Component of the transport system for branched-chain amino acids
M8970_RS09235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8970_RS09240	COG1309	transcriptional regulator
M8970_RS09245	COG1956	GAF domain-containing protein
M8970_RS09250	COG2199	diguanylate cyclase activity
M8970_RS09250	COG2203	Gaf domain
M8970_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS09265	COG4282	regulation of fungal-type cell wall biogenesis
M8970_RS09310	COG1017	nitric oxide dioxygenase activity
M8970_RS09310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8970_RS09320	COG0693	protein deglycase activity
M8970_RS09335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8970_RS09340	COG1378	Sugar-specific transcriptional regulator TrmB
M8970_RS09360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8970_RS09365	COG0454	-acetyltransferase
M8970_RS09370	COG0517	IMP dehydrogenase activity
M8970_RS09375	COG0123	including yeast histone deacetylase and acetoin utilization protein
M8970_RS09380	COG1360	Flagellar Motor Protein
M8970_RS09385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8970_RS09390	COG1609	Transcriptional regulator
M8970_RS09395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M8970_RS09395	COG1605	Chorismate mutase
M8970_RS09400	COG3118	belongs to the thioredoxin family
M8970_RS09405	COG4980	gas vesicle protein
M8970_RS09410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8970_RS09420	COG1674	ftsk spoiiie
M8970_RS09425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8970_RS09435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS09445	COG1363	Peptidase, m42
M8970_RS09450	COG5584	Small secreted protein
M8970_RS09455	COG0281	malic enzyme
M8970_RS09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS09475	COG0510	thiamine kinase activity
M8970_RS09480	COG1597	lipid kinase activity
M8970_RS09490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M8970_RS09495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8970_RS09500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8970_RS09505	COG2252	PERMEase
M8970_RS09510	COG4473	ABC transporter
M8970_RS09515	COG1131	(ABC) transporter
M8970_RS09520	COG1349	DNA-binding transcription factor activity
M8970_RS09525	COG1187	pseudouridine synthase activity
M8970_RS09530	COG2244	polysaccharide biosynthetic process
M8970_RS09535	COG2081	HI0933 family
M8970_RS09540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M8970_RS09550	COG1609	Transcriptional regulator
M8970_RS09555	COG1653	transport
M8970_RS09560	COG1175	transmembrane transport
M8970_RS09565	COG0395	ABC-type sugar transport system, permease component
M8970_RS09570	COG1486	melibiose metabolic process
M8970_RS09580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8970_RS09595	COG2202	Pas domain
M8970_RS09595	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS09600	COG2814	Major facilitator Superfamily
M8970_RS09605	COG5522	Integral membrane protein (intg_mem_TP0381)
M8970_RS09610	COG0577	efflux transmembrane transporter activity
M8970_RS09615	COG1136	(ABC) transporter
M8970_RS09620	COG2205	protein histidine kinase activity
M8970_RS09625	COG0745	RESPONSE REGULATOR receiver
M8970_RS09630	COG0577	efflux transmembrane transporter activity
M8970_RS09635	COG1136	(ABC) transporter
M8970_RS09655	COG1131	(ABC) transporter
M8970_RS09660	COG1725	Transcriptional regulator
M8970_RS09675	COG1242	4 iron, 4 sulfur cluster binding
M8970_RS09680	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M8970_RS09690	COG0584	glycerophosphoryl diester phosphodiesterase
M8970_RS09700	COG2267	carboxylic ester hydrolase activity
M8970_RS09705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8970_RS09710	COG1113	amino acid transport
M8970_RS09715	COG0367	asparagine synthase
M8970_RS09735	COG1506	peptidase
M8970_RS09740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8970_RS09745	COG1116	anion transmembrane transporter activity
M8970_RS09750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8970_RS09755	COG0494	nUDIX hydrolase
M8970_RS09760	COG4824	toxin secretion phage lysis holin
M8970_RS09765	COG0783	Belongs to the Dps family
M8970_RS09790	COG0288	reversible hydration of carbon dioxide
M8970_RS09800	COG1271	oxidase subunit
M8970_RS09805	COG1294	oxidase, subunit
M8970_RS09820	COG4948	Mandelate Racemase Muconate Lactonizing
M8970_RS09830	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M8970_RS09835	COG0596	Alpha beta hydrolase
M8970_RS09845	COG1169	isochorismate synthase
M8970_RS09850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8970_RS09855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M8970_RS09965	COG3859	Proton-coupled thiamine transporter YuaJ
M8970_RS09970	COG2268	Band 7 protein
M8970_RS09975	COG1585	Membrane protein implicated in regulation of membrane protease activity
M8970_RS09980	COG2318	DinB family
M8970_RS09990	COG1454	alcohol dehydrogenase
M8970_RS09995	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS10000	COG1510	regulation of RNA biosynthetic process
M8970_RS10010	COG0569	domain protein
M8970_RS10015	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8970_RS10020	COG1017	nitric oxide dioxygenase activity
M8970_RS10020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8970_RS10045	COG0628	permease
M8970_RS10050	COG0673	inositol 2-dehydrogenase activity
M8970_RS10055	COG0693	protein deglycase activity
M8970_RS10060	COG0840	transmembrane signaling receptor activity
M8970_RS10065	COG0840	transmembrane signaling receptor activity
M8970_RS10070	COG0840	transmembrane signaling receptor activity
M8970_RS10075	COG0840	transmembrane signaling receptor activity
M8970_RS10090	COG2070	2-Nitropropane dioxygenase
M8970_RS10095	COG0432	Pfam Uncharacterised protein family UPF0047
M8970_RS10100	COG0366	Alpha amylase catalytic
M8970_RS10105	COG1253	flavin adenine dinucleotide binding
M8970_RS10110	COG2738	Putative neutral zinc metallopeptidase
M8970_RS10125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M8970_RS10150	COG1335	isochorismatase
M8970_RS10155	COG1979	alcohol dehydrogenase
M8970_RS10160	COG1979	alcohol dehydrogenase
M8970_RS10165	COG2155	Conserved Protein
M8970_RS10170	COG1098	S1 RNA binding domain
M8970_RS10175	COG0436	Aminotransferase
M8970_RS10180	COG1522	sequence-specific DNA binding
M8970_RS10185	COG2267	carboxylic ester hydrolase activity
M8970_RS10195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M8970_RS10200	COG2205	protein histidine kinase activity
M8970_RS10210	COG5018	Exonuclease
M8970_RS10215	COG2814	Major facilitator Superfamily
M8970_RS10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8970_RS10225	COG3011	Protein conserved in bacteria
M8970_RS10235	COG3290	protein histidine kinase activity
M8970_RS10240	COG4565	transcriptional regulatory protein
M8970_RS10245	COG1744	ABC transporter substrate-binding protein PnrA-like
M8970_RS10250	COG3845	ABC transporter
M8970_RS10255	COG4603	Belongs to the binding-protein-dependent transport system permease family
M8970_RS10260	COG1079	Belongs to the binding-protein-dependent transport system permease family
M8970_RS10270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8970_RS10270	COG2111	Na H antiporter
M8970_RS10275	COG2111	Na H antiporter
M8970_RS10280	COG1006	Multisubunit Na H antiporter MnhC subunit
M8970_RS10285	COG0651	ATP synthesis coupled electron transport
M8970_RS10290	COG1863	multisubunit Na H antiporter MnhE subunit
M8970_RS10295	COG2212	antiporter activity
M8970_RS10300	COG1320	monovalent cation:proton antiporter activity
M8970_RS10305	COG2050	protein possibly involved in aromatic compounds catabolism
M8970_RS10310	COG2197	response regulator
M8970_RS10315	COG4585	Histidine kinase
M8970_RS10340	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M8970_RS10345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M8970_RS10350	COG1335	isochorismatase
M8970_RS10355	COG5506	Protein of unknown function (DUF1694)
M8970_RS10370	COG0628	permease
M8970_RS10380	COG1418	mRNA catabolic process
M8970_RS10385	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS10395	COG1511	domain protein
M8970_RS10400	COG0433	COG0433 Predicted ATPase
M8970_RS10400	COG1674	ftsk spoiiie
M8970_RS10405	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8970_RS10410	COG5417	Belongs to the EsaB family
M8970_RS10415	COG4842	Belongs to the WXG100 family
M8970_RS10420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M8970_RS10420	COG2508	Transcriptional regulator
M8970_RS10425	COG0686	Belongs to the AlaDH PNT family
M8970_RS10430	COG5634	Uncharacterized conserved protein (DUF2278)
M8970_RS10435	COG3251	PFAM MbtH domain protein
M8970_RS10440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS10445	COG3433	isochorismatase activity
M8970_RS10445	COG1535	isochorismatase
M8970_RS10450	COG1021	2,3-dihydroxybenzoate-AMP ligase
M8970_RS10455	COG1169	isochorismate synthase
M8970_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS10465	COG2819	hydrolase of the alpha beta superfamily
M8970_RS10470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8970_RS10475	COG1268	BioY protein
M8970_RS10480	COG2056	Na+-H+ antiporter family
M8970_RS10490	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M8970_RS10495	COG3584	3D domain protein
M8970_RS10510	COG1252	NADH dehydrogenase
M8970_RS10540	COG1131	(ABC) transporter
M8970_RS10560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8970_RS10565	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M8970_RS10570	COG0316	Belongs to the HesB IscA family
M8970_RS10580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8970_RS10590	COG1252	NADH dehydrogenase
M8970_RS10595	COG4837	Protein of unknown function (DUF1462)
M8970_RS10600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M8970_RS10605	COG1506	peptidase
M8970_RS10605	COG0823	Involved in the tonB-independent uptake of proteins
M8970_RS10605	COG4946	Tricorn protease homolog
M8970_RS10615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M8970_RS10620	COG0460	homoserine dehydrogenase
M8970_RS10625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8970_RS10630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M8970_RS10635	COG0647	UMP catabolic process
M8970_RS10640	COG2445	Protein of unknown function DUF86
M8970_RS10645	COG4470	Protein conserved in bacteria
M8970_RS10655	COG0739	heme binding
M8970_RS10665	COG0737	Belongs to the 5'-nucleotidase family
M8970_RS10670	COG0730	response to heat
M8970_RS10675	COG1801	Protein of unknown function DUF72
M8970_RS10690	COG2508	Transcriptional regulator
M8970_RS10715	COG2814	Major facilitator Superfamily
M8970_RS10720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M8970_RS10725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8970_RS10730	COG2356	endonuclease I
M8970_RS10735	COG3842	ATPase activity
M8970_RS10740	COG2188	Transcriptional regulator
M8970_RS10745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8970_RS10750	COG0395	ABC-type sugar transport system, permease component
M8970_RS10755	COG1175	transmembrane transport
M8970_RS10760	COG1653	transport
M8970_RS10765	COG2222	sugar isomerase
M8970_RS10770	COG0789	Transcriptional regulator
M8970_RS10795	COG0322	excinuclease ABC activity
M8970_RS10800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8970_RS10820	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS10825	COG0719	Fe-S assembly protein
M8970_RS10830	COG0822	iron-sulfur transferase activity
M8970_RS10835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8970_RS10840	COG0719	Fe-S assembly protein
M8970_RS10845	COG0396	ATPase activity
M8970_RS10855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8970_RS10860	COG1464	Belongs to the NlpA lipoprotein family
M8970_RS10865	COG2011	ABC-type metal ion transport system permease component
M8970_RS10870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8970_RS10880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS10885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8970_RS10900	COG1393	Belongs to the ArsC family
M8970_RS10905	COG1960	acyl-CoA dehydrogenase activity
M8970_RS10910	COG0183	Belongs to the thiolase family
M8970_RS10915	COG1024	Enoyl-CoA hydratase
M8970_RS10915	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8970_RS10935	COG5577	PFAM Coat F domain
M8970_RS10940	COG1846	Transcriptional regulator
M8970_RS10945	COG0477	Major facilitator Superfamily
M8970_RS10950	COG1942	4-Oxalocrotonate Tautomerase
M8970_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS10960	COG0583	DNA-binding transcription factor activity
M8970_RS10970	COG0583	DNA-binding transcription factor activity
M8970_RS10990	COG1120	ATPase activity
M8970_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS11010	COG0783	Belongs to the Dps family
M8970_RS11015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8970_RS11020	COG0745	RESPONSE REGULATOR receiver
M8970_RS11025	COG2770	Histidine kinase
M8970_RS11025	COG2205	protein histidine kinase activity
M8970_RS11035	COG1309	transcriptional regulator
M8970_RS11040	COG0114	fumarate hydratase activity
M8970_RS11050	COG0697	spore germination
M8970_RS11055	COG0814	amino acid
M8970_RS11065	COG2197	response regulator
M8970_RS11070	COG4585	Histidine kinase
M8970_RS11075	COG4758	membrane
M8970_RS11080	COG3595	metallopeptidase activity
M8970_RS11085	COG1842	Phage shock protein A
M8970_RS11090	COG4758	membrane
M8970_RS11095	COG2814	Major facilitator Superfamily
M8970_RS11100	COG2096	Adenosyltransferase
M8970_RS11105	COG1120	ATPase activity
M8970_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS11115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8970_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS11125	COG3386	PFAM SMP-30 Gluconolaconase
M8970_RS11130	COG2205	protein histidine kinase activity
M8970_RS11135	COG0745	RESPONSE REGULATOR receiver
M8970_RS11145	COG1191	sigma factor activity
M8970_RS11155	COG2140	Oxalate decarboxylase
M8970_RS11165	COG1120	ATPase activity
M8970_RS11170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS11175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS11180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8970_RS11185	COG0531	amino acid
M8970_RS11195	COG1988	membrane-bound metal-dependent
M8970_RS11200	COG1368	sulfuric ester hydrolase activity
M8970_RS11205	COG1910	domain protein
M8970_RS11210	COG0725	ABC transporter, periplasmic molybdate-binding protein
M8970_RS11215	COG4149	molybdate abc transporter
M8970_RS11220	COG2197	response regulator
M8970_RS11225	COG3850	Histidine kinase
M8970_RS11230	COG1131	(ABC) transporter
M8970_RS11240	COG0842	Transport permease protein
M8970_RS11245	COG0656	L-ascorbic acid biosynthetic process
M8970_RS11265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8970_RS11270	COG3973	AAA domain
M8970_RS11275	COG2860	membrane
M8970_RS11285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M8970_RS11290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M8970_RS11295	COG2217	Heavy metal translocating P-type atpase
M8970_RS11300	COG2217	Heavy metal translocating P-type atpase
M8970_RS11305	COG2608	mercury ion transmembrane transporter activity
M8970_RS11310	COG1937	Protein conserved in bacteria
M8970_RS11315	COG0673	inositol 2-dehydrogenase activity
M8970_RS11325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS11330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M8970_RS11335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS11340	COG1126	abc transporter atp-binding protein
M8970_RS11345	COG0765	amino acid transport
M8970_RS11350	COG0765	amino acid transport
M8970_RS11355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8970_RS11360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8970_RS11365	COG0454	-acetyltransferase
M8970_RS11370	COG0583	DNA-binding transcription factor activity
M8970_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS11420	COG0557	exoribonuclease II activity
M8970_RS11425	COG1647	Serine aminopeptidase, S33
M8970_RS11430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8970_RS11435	COG1476	TRANSCRIPTIONal
M8970_RS11440	COG1396	sequence-specific DNA binding
M8970_RS11445	COG1396	sequence-specific DNA binding
M8970_RS11450	COG1733	regulation of RNA biosynthetic process
M8970_RS11475	COG1131	(ABC) transporter
M8970_RS11480	COG1174	glycine betaine transport
M8970_RS11485	COG1732	Glycine betaine
M8970_RS11490	COG1174	glycine betaine transport
M8970_RS11495	COG0517	IMP dehydrogenase activity
M8970_RS11495	COG1125	glycine betaine transport
M8970_RS11500	COG1510	regulation of RNA biosynthetic process
M8970_RS11505	COG1174	glycine betaine transport
M8970_RS11510	COG1732	Glycine betaine
M8970_RS11515	COG1174	glycine betaine transport
M8970_RS11520	COG0517	IMP dehydrogenase activity
M8970_RS11520	COG1125	glycine betaine transport
M8970_RS11525	COG1510	regulation of RNA biosynthetic process
M8970_RS11530	COG2095	MarC family integral membrane protein
M8970_RS11535	COG3064	Membrane
M8970_RS11540	COG4640	response to antibiotic
M8970_RS11545	COG0456	acetyltransferase
M8970_RS11560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8970_RS11580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS11585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8970_RS11595	COG2234	aminopeptidase activity
M8970_RS11615	COG0126	phosphoglycerate kinase activity
M8970_RS11620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8970_RS11625	COG2390	Transcriptional regulator
M8970_RS11630	COG2814	Major facilitator Superfamily
M8970_RS11635	COG1609	Transcriptional regulator
M8970_RS11640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS11650	COG0583	DNA-binding transcription factor activity
M8970_RS11655	COG0697	spore germination
M8970_RS11660	COG1113	amino acid transport
M8970_RS11665	COG1609	Transcriptional regulator
M8970_RS11675	COG0561	phosphatase activity
M8970_RS11680	COG1737	Transcriptional regulator
M8970_RS11685	COG1070	Carbohydrate kinase
M8970_RS11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS11730	COG2186	Transcriptional regulator
M8970_RS11735	COG1620	l-lactate permease
M8970_RS11740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M8970_RS11750	COG5039	Polysaccharide pyruvyl transferase
M8970_RS11755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8970_RS11760	COG0110	maltose O-acetyltransferase activity
M8970_RS11765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M8970_RS11770	COG2244	polysaccharide biosynthetic process
M8970_RS11775	COG1216	Glycosyl transferase, family 2
M8970_RS11780	COG5039	Polysaccharide pyruvyl transferase
M8970_RS11785	COG1216	Glycosyl transferase, family 2
M8970_RS11795	COG0438	transferase activity, transferring glycosyl groups
M8970_RS11800	COG1215	transferase activity, transferring glycosyl groups
M8970_RS11805	COG0438	transferase activity, transferring glycosyl groups
M8970_RS11810	COG1086	Polysaccharide biosynthesis protein
M8970_RS11815	COG0489	protein tyrosine kinase activity
M8970_RS11820	COG3944	biosynthesis protein
M8970_RS11825	COG1396	sequence-specific DNA binding
M8970_RS11830	COG2272	Belongs to the type-B carboxylesterase lipase family
M8970_RS11835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8970_RS11840	COG2364	Membrane
M8970_RS11845	COG0456	acetyltransferase
M8970_RS11850	COG3479	Phenolic acid decarboxylase
M8970_RS11905	COG2223	nitrite transmembrane transporter activity
M8970_RS11910	COG1609	Transcriptional regulator
M8970_RS11920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8970_RS11925	COG0366	Alpha amylase catalytic
M8970_RS11930	COG1554	hydrolase, family 65, central catalytic
M8970_RS11935	COG5521	maltodextrose utilization protein MalA
M8970_RS11940	COG3833	ABC-type maltose transport systems, permease component
M8970_RS11945	COG1175	transmembrane transport
M8970_RS11950	COG2182	Extracellular solute-binding protein
M8970_RS11955	COG0366	Alpha amylase catalytic
M8970_RS11960	COG1609	Transcriptional regulator
M8970_RS11965	COG1611	Belongs to the LOG family
M8970_RS11970	COG1694	Mazg nucleotide pyrophosphohydrolase
M8970_RS11975	COG0659	secondary active sulfate transmembrane transporter activity
M8970_RS11980	COG0288	reversible hydration of carbon dioxide
M8970_RS11985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8970_RS11990	COG4290	ribonuclease
M8970_RS11995	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M8970_RS12000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS12010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M8970_RS12020	COG1051	belongs to the nudix hydrolase family
M8970_RS12025	COG0492	ferredoxin-NADP+ reductase activity
M8970_RS12030	COG0791	NLP P60 protein
M8970_RS12030	COG3883	PFAM NLP P60 protein
M8970_RS12035	COG0457	Tetratricopeptide repeat
M8970_RS12040	COG5002	protein histidine kinase activity
M8970_RS12045	COG0745	RESPONSE REGULATOR receiver
M8970_RS12050	COG1132	(ABC) transporter
M8970_RS12055	COG0140	phosphoribosyl-ATP diphosphatase activity
M8970_RS12055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M8970_RS12080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M8970_RS12095	COG4990	cell redox homeostasis
M8970_RS12100	COG0110	maltose O-acetyltransferase activity
M8970_RS12120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M8970_RS12130	COG2188	Transcriptional regulator
M8970_RS12135	COG1309	transcriptional regulator
M8970_RS12140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M8970_RS12145	COG1950	PFAM Membrane protein of
M8970_RS12150	COG1983	PspC domain protein
M8970_RS12155	COG3595	metallopeptidase activity
M8970_RS12170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M8970_RS12180	COG4897	Protein conserved in bacteria
M8970_RS12185	COG3848	Pyruvate phosphate dikinase
M8970_RS12185	COG0574	Belongs to the PEP-utilizing enzyme family
M8970_RS12190	COG1309	transcriptional regulator
M8970_RS12195	COG2814	Major facilitator Superfamily
M8970_RS12210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8970_RS12220	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS12220	COG0793	Belongs to the peptidase S41A family
M8970_RS12225	COG3420	alginic acid biosynthetic process
M8970_RS12230	COG2177	Part of the ABC transporter FtsEX involved in
M8970_RS12235	COG2884	Cell division ATP-binding protein ftsE
M8970_RS12240	COG2010	Cytochrome c
M8970_RS12245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS12260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M8970_RS12275	COG1516	flagellar protein fliS
M8970_RS12280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M8970_RS12285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8970_RS12305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8970_RS12310	COG1256	bacterial-type flagellum assembly
M8970_RS12310	COG4786	Flagellar basal body rod
M8970_RS12315	COG3418	PFAM FlgN family protein
M8970_RS12320	COG2747	anti-sigma28 factor FlgM
M8970_RS12330	COG1040	competence protein
M8970_RS12340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M8970_RS12345	COG1307	EDD domain protein, DegV family
M8970_RS12350	COG2197	response regulator
M8970_RS12355	COG4585	Histidine kinase
M8970_RS12360	COG1739	Uncharacterized protein family UPF0029
M8970_RS12365	COG1316	TRANSCRIPTIONal
M8970_RS12370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8970_RS12375	COG0438	transferase activity, transferring glycosyl groups
M8970_RS12380	COG1215	transferase activity, transferring glycosyl groups
M8970_RS12385	COG3206	protein involved in exopolysaccharide biosynthesis
M8970_RS12390	COG3307	-O-antigen
M8970_RS12395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8970_RS12400	COG0297	glycogen (starch) synthase activity
M8970_RS12400	COG0438	transferase activity, transferring glycosyl groups
M8970_RS12405	COG2244	polysaccharide biosynthetic process
M8970_RS12415	COG2247	cell wall binding repeat
M8970_RS12415	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS12420	COG2385	sporulation resulting in formation of a cellular spore
M8970_RS12420	COG2247	cell wall binding repeat
M8970_RS12430	COG1316	TRANSCRIPTIONal
M8970_RS12435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M8970_RS12440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8970_RS12445	COG1134	teichoic acid transport
M8970_RS12450	COG1682	transport, permease protein
M8970_RS12455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8970_RS12465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M8970_RS12470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M8970_RS12475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8970_RS12480	COG4193	domain, Protein
M8970_RS12485	COG1482	cell wall glycoprotein biosynthetic process
M8970_RS12490	COG0697	spore germination
M8970_RS12495	COG0814	amino acid
M8970_RS12505	COG1215	transferase activity, transferring glycosyl groups
M8970_RS12510	COG2814	Major facilitator Superfamily
M8970_RS12515	COG1316	TRANSCRIPTIONal
M8970_RS12520	COG0561	phosphatase activity
M8970_RS12525	COG2433	Pfam Transposase IS66
M8970_RS12530	COG0791	NLP P60 protein
M8970_RS12540	COG2843	Capsule synthesis protein
M8970_RS12550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8970_RS12555	COG0697	spore germination
M8970_RS12560	COG0814	amino acid
M8970_RS12570	COG1609	Transcriptional regulator
M8970_RS12575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8970_RS12585	COG1129	ABC transporter
M8970_RS12590	COG1172	Belongs to the binding-protein-dependent transport system permease family
M8970_RS12595	COG1879	ABC-type sugar transport system periplasmic component
M8970_RS12600	COG3103	Sh3 type 3 domain protein
M8970_RS12605	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8970_RS12610	COG3527	Alpha-acetolactate decarboxylase
M8970_RS12615	COG0028	Belongs to the TPP enzyme family
M8970_RS12620	COG0583	DNA-binding transcription factor activity
M8970_RS12625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8970_RS12640	COG5337	Spore coat protein CotH
M8970_RS12650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8970_RS12660	COG0405	Gamma-glutamyltransferase
M8970_RS12665	COG1522	sequence-specific DNA binding
M8970_RS12670	COG2059	Chromate
M8970_RS12675	COG2059	Chromate
M8970_RS12685	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8970_RS12690	COG0583	DNA-binding transcription factor activity
M8970_RS12720	COG5444	nuclease activity
M8970_RS12735	COG3878	Protein conserved in bacteria
M8970_RS12740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8970_RS12745	COG4464	protein tyrosine phosphatase activity
M8970_RS12750	COG0489	protein tyrosine kinase activity
M8970_RS12755	COG3944	biosynthesis protein
M8970_RS12765	COG4715	Zinc finger, swim domain protein
M8970_RS12770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8970_RS12775	COG0561	phosphatase activity
M8970_RS12780	COG1349	DNA-binding transcription factor activity
M8970_RS12785	COG0629	single-stranded DNA binding
M8970_RS12810	COG0457	Tetratricopeptide repeat
M8970_RS12815	COG4786	Flagellar basal body rod
M8970_RS12820	COG4786	Flagellar basal body rod
M8970_RS12825	COG1077	Cell shape determining protein MreB Mrl
M8970_RS12830	COG1609	Transcriptional regulator
M8970_RS12835	COG1846	Transcriptional regulator
M8970_RS12840	COG2814	Major facilitator Superfamily
M8970_RS12845	COG1953	Uracil, thiamine, allantoin
M8970_RS12850	COG0477	Major facilitator Superfamily
M8970_RS12855	COG1335	isochorismatase
M8970_RS12860	COG0004	ammonium transporteR
M8970_RS12865	COG0347	Belongs to the P(II) protein family
M8970_RS12870	COG0772	Belongs to the SEDS family
M8970_RS12875	COG0671	phosphoesterase, PA-phosphatase related
M8970_RS12885	COG0739	heme binding
M8970_RS12890	COG1247	-acetyltransferase
M8970_RS12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8970_RS12915	COG0726	polysaccharide deacetylase
M8970_RS12925	COG1959	2 iron, 2 sulfur cluster binding
M8970_RS12940	COG0831	urea catabolic process
M8970_RS12945	COG3237	CsbD-like
M8970_RS12950	COG1994	Peptidase M50
M8970_RS12955	COG0457	Tetratricopeptide repeat
M8970_RS12965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M8970_RS12975	COG2304	oxidoreductase activity
M8970_RS12980	COG2304	oxidoreductase activity
M8970_RS12985	COG2385	sporulation resulting in formation of a cellular spore
M8970_RS12990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8970_RS13000	COG4836	Membrane
M8970_RS13070	COG0698	ribose 5-phosphate isomerase
M8970_RS13075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8970_RS13085	COG0009	L-threonylcarbamoyladenylate synthase
M8970_RS13090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M8970_RS13110	COG2890	protein-(glutamine-N5) methyltransferase activity
M8970_RS13115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M8970_RS13120	COG0346	lactoylglutathione lyase activity
M8970_RS13125	COG0789	Transcriptional regulator
M8970_RS13130	COG0679	Auxin Efflux Carrier
M8970_RS13135	COG0281	malic enzyme
M8970_RS13150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M8970_RS13160	COG1494	fructose-1,6-bisphosphatase
M8970_RS13165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8970_RS13175	COG0191	fructose-bisphosphate aldolase activity
M8970_RS13180	COG2204	response regulator
M8970_RS13185	COG4821	SIS domain
M8970_RS13200	COG2181	nitrate reductase activity
M8970_RS13200	COG0247	lactate metabolic process
M8970_RS13205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8970_RS13220	COG1132	(ABC) transporter
M8970_RS13225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8970_RS13235	COG2181	nitrate reductase activity
M8970_RS13240	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M8970_RS13245	COG1140	nitrate reductase beta subunit
M8970_RS13250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M8970_RS13255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8970_RS13265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8970_RS13270	COG2223	nitrite transmembrane transporter activity
M8970_RS13280	COG4506	Protein conserved in bacteria
M8970_RS13290	COG3391	amine dehydrogenase activity
M8970_RS13295	COG3391	amine dehydrogenase activity
M8970_RS13300	COG0457	Tetratricopeptide repeat
M8970_RS13310	COG0010	Belongs to the arginase family
M8970_RS13315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M8970_RS13320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8970_RS13335	COG1994	Peptidase M50
M8970_RS13340	COG1942	4-Oxalocrotonate Tautomerase
M8970_RS13345	COG1846	Transcriptional regulator
M8970_RS13350	COG0531	amino acid
M8970_RS13355	COG3465	dGTPase activity
M8970_RS13360	COG1078	dGTPase activity
M8970_RS13375	COG1695	Transcriptional regulator
M8970_RS13385	COG1131	(ABC) transporter
M8970_RS13390	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8970_RS13420	COG0583	DNA-binding transcription factor activity
M8970_RS13425	COG2855	membrane
M8970_RS13430	COG0280	phosphate acetyltransferase
M8970_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS13445	COG0436	Aminotransferase
M8970_RS13475	COG2814	Major facilitator Superfamily
M8970_RS13480	COG2814	Major facilitator Superfamily
M8970_RS13485	COG0833	amino acid
M8970_RS13490	COG4187	Peptidase family M20/M25/M40
M8970_RS13495	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS13500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8970_RS13505	COG2205	protein histidine kinase activity
M8970_RS13510	COG0745	RESPONSE REGULATOR receiver
M8970_RS13525	COG1131	(ABC) transporter
M8970_RS13530	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M8970_RS13535	COG1091	dTDP-4-dehydrorhamnose reductase activity
M8970_RS13540	COG1088	dTDP-glucose 4,6-dehydratase activity
M8970_RS13545	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M8970_RS13550	COG3980	spore coat polysaccharide biosynthesis protein
M8970_RS13555	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M8970_RS13560	COG2089	acid synthase
M8970_RS13565	COG0456	acetyltransferase
M8970_RS13570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8970_RS13575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8970_RS13580	COG0463	Glycosyl transferase, family 2
M8970_RS13590	COG2363	Small membrane protein
M8970_RS13595	COG2233	PERMEase
M8970_RS13610	COG1216	Glycosyl transferase, family 2
M8970_RS13625	COG1695	Transcriptional regulator
M8970_RS13630	COG0351	phosphomethylpyrimidine kinase
M8970_RS13640	COG1621	beta-fructofuranosidase activity
M8970_RS13645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS13645	COG1263	PTS System
M8970_RS13650	COG3711	transcriptional antiterminator
M8970_RS13660	COG1404	Belongs to the peptidase S8 family
M8970_RS13665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS13670	COG0778	Nitroreductase
M8970_RS13675	COG0772	Belongs to the SEDS family
M8970_RS13680	COG0454	-acetyltransferase
M8970_RS13700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8970_RS13705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8970_RS13710	COG2261	transglycosylase associated protein
M8970_RS13715	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8970_RS13720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8970_RS13725	COG2246	polysaccharide biosynthetic process
M8970_RS13730	COG1309	transcriptional regulator
M8970_RS13750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8970_RS13755	COG2837	iron assimilation
M8970_RS13775	COG0583	DNA-binding transcription factor activity
M8970_RS13785	COG1346	cytolysis
M8970_RS13790	COG4895	conserved protein (DUF2196)
M8970_RS13795	COG0789	Transcriptional regulator
M8970_RS13800	COG5504	Zn-dependent protease
M8970_RS13805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M8970_RS13810	COG0346	lactoylglutathione lyase activity
M8970_RS13815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS13820	COG1404	Belongs to the peptidase S8 family
M8970_RS13825	COG1442	glycosyl transferase family 8
M8970_RS13830	COG2357	RelA SpoT domain protein
M8970_RS13835	COG1575	Belongs to the MenA family. Type 1 subfamily
M8970_RS13850	COG1696	Membrane protein involved in D-alanine export
M8970_RS13860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M8970_RS13865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8970_RS13870	COG1486	melibiose metabolic process
M8970_RS13875	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8970_RS13880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS13885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS13890	COG3711	transcriptional antiterminator
M8970_RS13890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS13900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS13905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS13915	COG0640	Transcriptional regulator
M8970_RS13920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8970_RS13925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS13930	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8970_RS13935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8970_RS13940	COG2723	6-phospho-beta-galactosidase activity
M8970_RS13950	COG1482	cell wall glycoprotein biosynthetic process
M8970_RS13960	COG0753	catalase activity
M8970_RS13965	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M8970_RS13970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8970_RS13990	COG3279	Response regulator of the LytR AlgR family
M8970_RS14010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M8970_RS14015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M8970_RS14020	COG4988	ABC transporter
M8970_RS14025	COG1294	oxidase, subunit
M8970_RS14030	COG1271	oxidase subunit
M8970_RS14035	COG3493	citrate carrier protein
M8970_RS14040	COG0726	polysaccharide deacetylase
M8970_RS14045	COG3842	ATPase activity
M8970_RS14050	COG2508	Transcriptional regulator
M8970_RS14055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS14065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8970_RS14080	COG4894	glucomannan catabolic process
M8970_RS14085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M8970_RS14090	COG0500	methyltransferase
M8970_RS14095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8970_RS14110	COG0693	protein deglycase activity
M8970_RS14110	COG0753	catalase activity
M8970_RS14115	COG2851	Citrate transporter
M8970_RS14120	COG2273	Hydrolase Family 16
M8970_RS14130	COG2270	Major facilitator Superfamily
M8970_RS14135	COG0513	Belongs to the DEAD box helicase family
M8970_RS14145	COG0697	spore germination
M8970_RS14150	COG0589	response to stress
M8970_RS14210	COG3507	Belongs to the glycosyl hydrolase 43 family
M8970_RS14235	COG0010	Belongs to the arginase family
M8970_RS14240	COG0833	amino acid
M8970_RS14245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M8970_RS14250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8970_RS14260	COG2390	Transcriptional regulator
M8970_RS14265	COG0561	phosphatase activity
M8970_RS14295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8970_RS14300	COG5294	Protein conserved in bacteria
M8970_RS14305	COG0577	efflux transmembrane transporter activity
M8970_RS14310	COG1136	(ABC) transporter
M8970_RS14315	COG2205	protein histidine kinase activity
M8970_RS14320	COG0745	RESPONSE REGULATOR receiver
M8970_RS14325	COG2205	protein histidine kinase activity
M8970_RS14330	COG0745	RESPONSE REGULATOR receiver
M8970_RS14360	COG1082	Xylose isomerase domain protein TIM barrel
M8970_RS14370	COG2814	Major facilitator Superfamily
M8970_RS14400	COG1349	DNA-binding transcription factor activity
M8970_RS14405	COG0667	Aldo Keto reductase
M8970_RS14410	COG2814	Major facilitator Superfamily
M8970_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS14430	COG2197	response regulator
M8970_RS14435	COG4585	Histidine kinase
M8970_RS14440	COG3239	Fatty acid desaturase
M8970_RS14445	COG1309	transcriptional regulator
M8970_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS14455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M8970_RS14465	COG0640	Transcriptional regulator
M8970_RS14470	COG2814	Major facilitator Superfamily
M8970_RS14475	COG1714	RDD family
M8970_RS14485	COG0450	alkyl hydroperoxide reductase
M8970_RS14490	COG3634	alkyl hydroperoxide reductase activity
M8970_RS14495	COG3177	Filamentation induced by cAMP protein fic
M8970_RS14500	COG1113	amino acid transport
M8970_RS14510	COG2080	2 iron, 2 sulfur cluster binding
M8970_RS14525	COG2068	MobA-Related Protein
M8970_RS14530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M8970_RS14585	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8970_RS14590	COG0667	Aldo Keto reductase
M8970_RS14595	COG0456	acetyltransferase
M8970_RS14600	COG0457	Tetratricopeptide repeat
M8970_RS14605	COG0010	Belongs to the arginase family
M8970_RS14610	COG0833	amino acid
M8970_RS14615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8970_RS14620	COG5658	integral membrane protein
M8970_RS14625	COG0640	Transcriptional regulator
M8970_RS14630	COG3829	transcription factor binding
M8970_RS14640	COG0488	(ABC) transporter
M8970_RS14655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8970_RS14660	COG3850	Histidine kinase
M8970_RS14660	COG5002	protein histidine kinase activity
M8970_RS14670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8970_RS14675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M8970_RS14680	COG4853	Protein conserved in bacteria
M8970_RS14685	COG4863	YycH protein
M8970_RS14690	COG5002	protein histidine kinase activity
M8970_RS14695	COG0745	RESPONSE REGULATOR receiver
M8970_RS14725	COG0346	lactoylglutathione lyase activity
M8970_RS14730	COG0305	Participates in initiation and elongation during chromosome replication
M8970_RS14745	COG3093	addiction module antidote protein HigA
M8970_RS14750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8970_RS14755	COG0297	glycogen (starch) synthase activity
M8970_RS14765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M8970_RS14770	COG0438	transferase activity, transferring glycosyl groups
M8970_RS14790	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M8970_RS14795	COG4241	membrane
M8970_RS14805	COG5577	PFAM Coat F domain
M8970_RS14810	COG1733	regulation of RNA biosynthetic process
M8970_RS14820	COG0697	spore germination
M8970_RS14825	COG1621	beta-fructofuranosidase activity
M8970_RS14830	COG1621	beta-fructofuranosidase activity
M8970_RS14840	COG2318	DinB family
M8970_RS14845	COG2211	Major facilitator Superfamily
M8970_RS14855	COG0778	Nitroreductase
M8970_RS14865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS14870	COG1846	Transcriptional regulator
M8970_RS14875	COG2153	protein acetylation
M8970_RS14885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8970_RS14890	COG0583	DNA-binding transcription factor activity
M8970_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS14900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS14905	COG0697	spore germination
M8970_RS14935	COG1331	Highly conserved protein containing a thioredoxin domain
M8970_RS14940	COG1266	CAAX protease self-immunity
M8970_RS14945	COG2814	Major facilitator Superfamily
M8970_RS14945	COG0477	Major facilitator Superfamily
M8970_RS14950	COG0346	lactoylglutathione lyase activity
M8970_RS14955	COG1609	Transcriptional regulator
M8970_RS14960	COG0708	Exodeoxyribonuclease III
M8970_RS14965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8970_RS14970	COG2169	Transcriptional regulator
M8970_RS14980	COG0629	single-stranded DNA binding
M8970_RS14990	COG0012	GTP binding
M8970_RS14995	COG0243	molybdopterin cofactor binding
M8970_RS15000	COG4481	Protein conserved in bacteria
M8970_RS15005	COG3949	Membrane
M8970_RS15020	COG1475	DNA binding
M8970_RS15025	COG1192	Involved in chromosome partitioning
M8970_RS15050	COG1847	R3H domain protein
M8970_RS15055	COG0706	membrane insertase activity
M8970_RS15075	COG0592	DNA-directed DNA polymerase activity
M8970_RS15080	COG2501	S4 domain
M8970_RS15095	COG0187	DNA topoisomerase II activity
M8970_RS15100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8970_RS15115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M8970_RS15120	COG0802	atpase or kinase
M8970_RS15125	COG1214	PFAM Peptidase M22, glycoprotease
M8970_RS15130	COG0456	acetyltransferase
M8970_RS15135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M8970_RS15140	COG0488	(ABC) transporter
M8970_RS15155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8970_RS15160	COG0805	protein transport
M8970_RS15170	COG1266	CAAX protease self-immunity
M8970_RS15215	COG0457	Tetratricopeptide repeat
M8970_RS15220	COG1063	alcohol dehydrogenase
M8970_RS15225	COG2211	Major facilitator Superfamily
M8970_RS15230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8970_RS15240	COG1842	Phage shock protein A
M8970_RS15245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8970_RS15250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M8970_RS15255	COG4260	virion core protein, lumpy skin disease virus
M8970_RS15260	COG2755	lipolytic protein G-D-S-L family
M8970_RS15260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M8970_RS15270	COG1595	DNA-templated transcription, initiation
M8970_RS15275	COG1063	alcohol dehydrogenase
M8970_RS15280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8970_RS15285	COG0823	Involved in the tonB-independent uptake of proteins
M8970_RS15295	COG2132	Multicopper oxidase
M8970_RS15300	COG1113	amino acid transport
M8970_RS15305	COG0714	Associated with various cellular activities
M8970_RS15310	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M8970_RS15315	COG1305	Transglutaminase-like
M8970_RS15340	COG2252	PERMEase
M8970_RS15345	COG3064	Membrane
M8970_RS15365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M8970_RS15370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M8970_RS15375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M8970_RS15380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M8970_RS15385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8970_RS15400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M8970_RS15410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M8970_RS15415	COG0138	bifunctional purine biosynthesis protein purh
M8970_RS15420	COG0151	Belongs to the GarS family
M8970_RS15430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M8970_RS15435	COG1470	cell adhesion involved in biofilm formation
M8970_RS15440	COG4496	protein, YerC YecD
M8970_RS15445	COG0069	glutamate synthase activity
M8970_RS15455	COG0210	DNA helicase
M8970_RS15465	COG4851	CamS sex pheromone cAM373 precursor
M8970_RS15470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8970_RS15475	COG1285	pathogenesis
M8970_RS15480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8970_RS15500	COG1309	transcriptional regulator
M8970_RS15505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8970_RS15510	COG1597	lipid kinase activity
M8970_RS15515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8970_RS15525	COG1131	(ABC) transporter
M8970_RS15565	COG5444	nuclease activity
M8970_RS15595	COG3546	catalase activity
M8970_RS15600	COG0454	-acetyltransferase
M8970_RS15610	COG2323	membrane
M8970_RS15615	COG2329	Antibiotic biosynthesis monooxygenase
M8970_RS15620	COG0346	lactoylglutathione lyase activity
M8970_RS15625	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS15630	COG5583	Uncharacterized small protein (DUF2292)
M8970_RS15635	COG0196	riboflavin kinase activity
M8970_RS15640	COG0670	Belongs to the BI1 family
M8970_RS15645	COG1846	Transcriptional regulator
M8970_RS15650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8970_RS15660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8970_RS15660	COG2124	cytochrome p450
M8970_RS15665	COG1368	sulfuric ester hydrolase activity
M8970_RS15670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M8970_RS15675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8970_RS15680	COG1442	glycosyl transferase family 8
M8970_RS15685	COG1216	Glycosyl transferase, family 2
M8970_RS15690	COG1442	glycosyl transferase family 8
M8970_RS15695	COG2223	nitrite transmembrane transporter activity
M8970_RS15700	COG0531	amino acid
M8970_RS15705	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS15710	COG0840	transmembrane signaling receptor activity
M8970_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS15720	COG0463	Glycosyl transferase, family 2
M8970_RS15720	COG0457	Tetratricopeptide repeat
M8970_RS15725	COG0488	(ABC) transporter
M8970_RS15730	COG0789	Transcriptional regulator
M8970_RS15735	COG2814	Major facilitator Superfamily
M8970_RS15740	COG0488	(ABC) transporter
M8970_RS15745	COG0513	Belongs to the DEAD box helicase family
M8970_RS15750	COG0456	acetyltransferase
M8970_RS15755	COG2130	NADP-dependent
M8970_RS15770	COG3866	Pectate lyase
M8970_RS15775	COG0471	metal ion transport
M8970_RS15805	COG3290	protein histidine kinase activity
M8970_RS15810	COG4565	transcriptional regulatory protein
M8970_RS15815	COG3181	Tripartite tricarboxylate transporter family receptor
M8970_RS15820	COG2851	Citrate transporter
M8970_RS15825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8970_RS15830	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M8970_RS15840	COG2258	MOSC domain
M8970_RS15860	COG0024	Methionine aminopeptidase
M8970_RS15865	COG1263	PTS System
M8970_RS15865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS15875	COG1368	sulfuric ester hydrolase activity
M8970_RS15885	COG0071	Belongs to the small heat shock protein (HSP20) family
M8970_RS15900	COG1263	PTS System
M8970_RS15900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS15905	COG0366	Alpha amylase catalytic
M8970_RS15910	COG2188	Transcriptional regulator
M8970_RS15915	COG0778	Nitroreductase
M8970_RS15930	COG0737	Belongs to the 5'-nucleotidase family
M8970_RS15935	COG0693	protein deglycase activity
M8970_RS15940	COG1609	Transcriptional regulator
M8970_RS15955	COG2814	Major facilitator Superfamily
M8970_RS15965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8970_RS15970	COG4980	gas vesicle protein
M8970_RS15975	COG1295	ribonuclease BN
M8970_RS15980	COG0477	Major facilitator Superfamily
M8970_RS15985	COG0387	Pfam Sodium calcium exchanger
M8970_RS15995	COG0668	transmembrane transport
M8970_RS16000	COG0535	radical SAM domain protein
M8970_RS16010	COG0726	polysaccharide deacetylase
M8970_RS16030	COG0745	RESPONSE REGULATOR receiver
M8970_RS16035	COG2205	protein histidine kinase activity
M8970_RS16040	COG2084	Dehydrogenase
M8970_RS16050	COG0598	Magnesium transport protein CorA
M8970_RS16055	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M8970_RS16060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8970_RS16075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8970_RS16080	COG4637	Psort location Cytoplasmic, score
M8970_RS16085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8970_RS16090	COG0022	dehydrogenase e1 component
M8970_RS16095	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8970_RS16100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8970_RS16105	COG3284	Transcriptional regulator
M8970_RS16115	COG1486	melibiose metabolic process
M8970_RS16120	COG1737	Transcriptional regulator
M8970_RS16125	COG1263	PTS System
M8970_RS16125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS16130	COG5434	Belongs to the glycosyl hydrolase 28 family
M8970_RS16135	COG5434	Belongs to the glycosyl hydrolase 28 family
M8970_RS16140	COG1132	(ABC) transporter
M8970_RS16145	COG1132	(ABC) transporter
M8970_RS16150	COG2259	Doxx family
M8970_RS16155	COG2514	catechol 2,3-dioxygenase activity
M8970_RS16170	COG1695	Transcriptional regulator
M8970_RS16175	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8970_RS16180	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M8970_RS16185	COG3848	Pyruvate phosphate dikinase
M8970_RS16185	COG0574	Belongs to the PEP-utilizing enzyme family
M8970_RS16190	COG2732	(Barnase) inhibitor
M8970_RS16195	COG2318	DinB family
M8970_RS16200	COG2814	Major facilitator Superfamily
M8970_RS16205	COG1846	Transcriptional regulator
M8970_RS16210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M8970_RS16210	COG0392	lysyltransferase activity
M8970_RS16215	COG0384	phenazine biosynthesis protein PhzF
M8970_RS16220	COG0778	Nitroreductase
M8970_RS16235	COG1090	epimerase
M8970_RS16250	COG2814	Major facilitator Superfamily
M8970_RS16260	COG3591	Belongs to the peptidase S1B family
M8970_RS16275	COG3103	Sh3 type 3 domain protein
M8970_RS16280	COG5658	integral membrane protein
M8970_RS16285	COG0596	Alpha beta hydrolase
M8970_RS16290	COG0463	Glycosyl transferase, family 2
M8970_RS16295	COG4485	Bacterial membrane protein, YfhO
M8970_RS16300	COG1988	membrane-bound metal-dependent
M8970_RS16305	COG1194	a g-specific adenine glycosylase
M8970_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS16335	COG1132	(ABC) transporter
M8970_RS16340	COG4129	membrane
M8970_RS16350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M8970_RS16355	COG0735	belongs to the Fur family
M8970_RS16370	COG0738	Major facilitator superfamily
M8970_RS16375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8970_RS16385	COG1063	alcohol dehydrogenase
M8970_RS16390	COG0659	secondary active sulfate transmembrane transporter activity
M8970_RS16395	COG0385	Bile acid
M8970_RS16400	COG2819	hydrolase of the alpha beta superfamily
M8970_RS16405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS16410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS16415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8970_RS16420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8970_RS16420	COG2207	Transcriptional regulator
M8970_RS16425	COG3876	Protein conserved in bacteria
M8970_RS16430	COG1472	Belongs to the glycosyl hydrolase 3 family
M8970_RS16435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8970_RS16440	COG1263	PTS System
M8970_RS16440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8970_RS16450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8970_RS16455	COG1683	Conserved Protein
M8970_RS16485	COG1595	DNA-templated transcription, initiation
M8970_RS16490	COG5662	AntiSigma factor
M8970_RS16495	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8970_RS16500	COG4856	YbbR-like protein
M8970_RS16535	COG5002	protein histidine kinase activity
M8970_RS16540	COG1136	(ABC) transporter
M8970_RS16545	COG0577	efflux transmembrane transporter activity
M8970_RS16550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8970_RS16565	COG1346	cytolysis
M8970_RS16570	COG1380	Effector of murein hydrolase LrgA
M8970_RS16575	COG1846	Transcriptional regulator
M8970_RS16580	COG1113	amino acid transport
M8970_RS16585	COG1011	Hydrolase
M8970_RS16590	COG4585	Histidine kinase
M8970_RS16595	COG2197	response regulator
M8970_RS16600	COG1131	(ABC) transporter
M8970_RS16640	COG0531	amino acid
M8970_RS16645	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8970_RS16660	COG0584	glycerophosphoryl diester phosphodiesterase
M8970_RS16665	COG2271	Major facilitator Superfamily
M8970_RS16675	COG2368	4-hydroxyphenylacetate
M8970_RS16685	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS16700	COG1397	ADP-ribosylglycohydrolase
M8970_RS16705	COG5444	nuclease activity
M8970_RS16715	COG0371	Dehydrogenase
M8970_RS16725	COG1183	phosphatidylcholine synthase activity
M8970_RS16730	COG0586	Pfam SNARE associated Golgi protein
M8970_RS16735	COG0688	phosphatidylethanolamine metabolic process
M8970_RS16750	COG1301	dicarboxylic acid transport
M8970_RS16755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8970_RS16760	COG0833	amino acid
M8970_RS16765	COG2040	homocysteine
M8970_RS16770	COG1115	amino acid carrier protein
M8970_RS16775	COG2066	Belongs to the glutaminase family
M8970_RS16780	COG4191	Histidine kinase
M8970_RS16785	COG0784	Response regulator, receiver
M8970_RS16805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8970_RS16810	COG0778	Nitroreductase
M8970_RS16815	COG0346	lactoylglutathione lyase activity
M8970_RS16820	COG2259	Doxx family
M8970_RS16825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS16840	COG3773	Cell wall hydrolase
M8970_RS16845	COG3540	Alkaline phosphatase
M8970_RS16850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8970_RS16855	COG0805	protein transport
M8970_RS16865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8970_RS16870	COG0477	Major facilitator Superfamily
M8970_RS16875	COG1309	transcriptional regulator
M8970_RS16880	COG0252	asparaginase activity
M8970_RS16885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M8970_RS16890	COG3012	SEC-C Motif Domain Protein
M8970_RS16890	COG1405	negative regulation of cell septum assembly
M8970_RS16905	COG1595	DNA-templated transcription, initiation
M8970_RS16910	COG1595	DNA-templated transcription, initiation
M8970_RS16915	COG1876	peptidase activity
M8970_RS16920	COG0457	Tetratricopeptide repeat
M8970_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS16930	COG0366	Alpha amylase catalytic
M8970_RS16935	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8970_RS16940	COG1121	(ABC) transporter
M8970_RS16945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8970_RS16950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS16955	COG2310	stress, protein
M8970_RS16960	COG2310	stress, protein
M8970_RS16965	COG2310	stress, protein
M8970_RS16970	COG0861	Integral membrane protein TerC family
M8970_RS16980	COG3853	Toxic anion resistance protein (TelA)
M8970_RS16985	COG0477	Major facilitator Superfamily
M8970_RS16990	COG0517	IMP dehydrogenase activity
M8970_RS16990	COG4175	Glycine betaine
M8970_RS16995	COG4176	ABC-type proline glycine betaine transport system permease component
M8970_RS17000	COG2113	Glycine betaine
M8970_RS17005	COG1473	amidohydrolase
M8970_RS17010	COG1288	antiporter activity
M8970_RS17030	COG2814	Major facilitator Superfamily
M8970_RS17035	COG1846	Transcriptional regulator
M8970_RS17040	COG1280	lysine exporter protein (LysE YggA)
M8970_RS17045	COG3403	YqcI/YcgG family
M8970_RS17050	COG1113	amino acid transport
M8970_RS17055	COG3665	Urea carboxylase-associated protein
M8970_RS17070	COG1660	Displays ATPase and GTPase activities
M8970_RS17075	COG1082	Xylose isomerase domain protein TIM barrel
M8970_RS17080	COG2271	Major facilitator Superfamily
M8970_RS17085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M8970_RS17090	COG3458	cephalosporin-C deacetylase activity
M8970_RS17095	COG3541	Predicted nucleotidyltransferase
M8970_RS17100	COG0506	proline dehydrogenase activity
M8970_RS17105	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS17110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8970_RS17115	COG2508	Transcriptional regulator
M8970_RS17125	COG1587	Uroporphyrinogen-III synthase
M8970_RS17125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8970_RS17130	COG2146	nitrite reductase [NAD(P)H] activity
M8970_RS17135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8970_RS17140	COG0243	molybdopterin cofactor binding
M8970_RS17145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8970_RS17150	COG2223	nitrite transmembrane transporter activity
M8970_RS17155	COG0523	cobalamin synthesis protein
M8970_RS17160	COG1063	alcohol dehydrogenase
M8970_RS17165	COG1714	RDD family
M8970_RS17185	COG3209	COG3209 Rhs family protein
M8970_RS17190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M8970_RS17195	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M8970_RS17200	COG1733	regulation of RNA biosynthetic process
M8970_RS17205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS17225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS17230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8970_RS17235	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M8970_RS17250	COG2364	Membrane
M8970_RS17255	COG1126	abc transporter atp-binding protein
M8970_RS17260	COG0765	amino acid transport
M8970_RS17270	COG0583	DNA-binding transcription factor activity
M8970_RS17275	COG0163	prenyltransferase activity
M8970_RS17280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M8970_RS17295	COG3104	oligopeptide transport
M8970_RS17300	COG5434	Belongs to the glycosyl hydrolase 28 family
M8970_RS17310	COG0697	spore germination
M8970_RS17320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8970_RS17325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8970_RS17330	COG0456	acetyltransferase
M8970_RS17335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8970_RS17340	COG0765	amino acid transport
M8970_RS17345	COG1126	abc transporter atp-binding protein
M8970_RS17350	COG1473	amidohydrolase
M8970_RS17355	COG2079	MmgE PrpD family protein
M8970_RS17360	COG1136	(ABC) transporter
M8970_RS17365	COG0577	efflux transmembrane transporter activity
M8970_RS17370	COG0745	RESPONSE REGULATOR receiver
M8970_RS17375	COG3850	Histidine kinase
M8970_RS17375	COG5002	protein histidine kinase activity
M8970_RS17380	COG0457	Tetratricopeptide repeat
M8970_RS17395	COG0527	aspartate kinase activity
M8970_RS17400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8970_RS17405	COG4605	iron ion homeostasis
M8970_RS17410	COG4604	ABC transporter, ATP-binding protein
M8970_RS17415	COG4607	ABC-type enterochelin transport system periplasmic component
M8970_RS17420	COG2814	Major facilitator Superfamily
M8970_RS17425	COG1309	transcriptional regulator
M8970_RS17430	COG0778	Nitroreductase
M8970_RS17435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8970_RS17440	COG0640	Transcriptional regulator
M8970_RS17445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS17450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8970_RS17455	COG1012	belongs to the aldehyde dehydrogenase family
M8970_RS17460	COG4975	Glucose uptake
M8970_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS17470	COG4549	nuclear export factor GLE1
M8970_RS17475	COG2372	response to copper ion
M8970_RS17475	COG1276	copper resistance
M8970_RS17480	COG1349	DNA-binding transcription factor activity
M8970_RS17490	COG2213	PTS system mannitol-specific
M8970_RS17495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8970_RS17505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M8970_RS17515	COG0561	phosphatase activity
M8970_RS17525	COG1914	H( )-stimulated, divalent metal cation uptake system
M8970_RS17535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8970_RS17540	COG1984	allophanate hydrolase subunit 2
M8970_RS17545	COG1414	Transcriptional regulator
M8970_RS17550	COG2755	lipolytic protein G-D-S-L family
M8970_RS17560	COG2329	Antibiotic biosynthesis monooxygenase
M8970_RS17565	COG0768	penicillin binding
M8970_RS17570	COG4989	oxidoreductase activity
M8970_RS17575	COG3711	transcriptional antiterminator
M8970_RS17580	COG0318	PFAM AMP-dependent synthetase and ligase
M8970_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
M8970_RS17590	COG1917	Cupin 2, conserved barrel domain protein
M8970_RS17595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8970_RS17600	COG3871	stress protein (general stress protein 26)
M8970_RS17610	COG2814	Major facilitator Superfamily
M8970_RS17615	COG1522	sequence-specific DNA binding
M8970_RS17620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8970_RS17620	COG0551	DNA topoisomerase type I activity
M8970_RS17625	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M8970_RS17630	COG3706	GGDEF domain
M8970_RS17635	COG5298	Protein conserved in bacteria
M8970_RS17640	COG1215	transferase activity, transferring glycosyl groups
M8970_RS17650	COG0531	amino acid
M8970_RS17660	COG0028	Belongs to the TPP enzyme family
M8970_RS17665	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8970_RS17665	COG3409	Peptidoglycan-binding domain 1 protein
M8970_RS17665	COG1388	LysM domain
M8970_RS17685	COG0457	Tetratricopeptide repeat
M8970_RS17710	COG1914	H( )-stimulated, divalent metal cation uptake system
M8970_RS17730	COG2076	Multidrug Resistance protein
M8970_RS17735	COG2217	Heavy metal translocating P-type atpase
M8970_RS17740	COG3729	General stress protein
M8970_RS17745	COG0662	Cupin 2, conserved barrel domain protein
M8970_RS17750	COG2329	Antibiotic biosynthesis monooxygenase
M8970_RS17755	COG3546	catalase activity
M8970_RS17760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M8970_RS17765	COG3290	protein histidine kinase activity
M8970_RS17770	COG4565	transcriptional regulatory protein
M8970_RS17775	COG1301	dicarboxylic acid transport
M8970_RS17780	COG0628	permease
M8970_RS17785	COG1131	(ABC) transporter
M8970_RS17790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8970_RS17800	COG1960	acyl-CoA dehydrogenase activity
M8970_RS17815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8970_RS17820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8970_RS17830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M8970_RS17835	COG0513	Belongs to the DEAD box helicase family
M8970_RS17840	COG3402	PFAM membrane-flanked domain
M8970_RS17845	COG3428	Bacterial PH domain
M8970_RS17850	COG0705	Rhomboid family
M8970_RS17860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M8970_RS17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8970_RS17870	COG0864	Transcriptional regulator
M8970_RS17875	COG2337	Toxic component of a toxin-antitoxin (TA) module
M8970_RS17880	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS17885	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS17890	COG2172	sigma factor antagonist activity
M8970_RS17895	COG2208	phosphoserine phosphatase activity
M8970_RS17900	COG1366	Belongs to the anti-sigma-factor antagonist family
M8970_RS17910	COG1191	sigma factor activity
M8970_RS17915	COG2208	phosphoserine phosphatase activity
M8970_RS17920	COG2183	response to ionizing radiation
M8970_RS17985	COG5444	nuclease activity
M8970_RS18005	COG0477	Major facilitator Superfamily
M8970_RS18020	COG2030	dehydratase
M8970_RS18030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8970_RS18035	COG1959	2 iron, 2 sulfur cluster binding
M8970_RS18040	COG2910	NAD(P)H-binding
M8970_RS18045	COG3239	Fatty acid desaturase
M8970_RS18050	COG1278	Cold shock
M8970_RS18055	COG1329	Transcriptional regulator
M8970_RS18060	COG1937	Protein conserved in bacteria
M8970_RS18065	COG2210	Belongs to the sulfur carrier protein TusA family
M8970_RS18070	COG1054	Belongs to the UPF0176 family
M8970_RS18075	COG0425	Belongs to the sulfur carrier protein TusA family
M8970_RS18075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8970_RS18085	COG0425	Belongs to the sulfur carrier protein TusA family
M8970_RS18090	COG0730	response to heat
M8970_RS18095	COG1794	racemase activity, acting on amino acids and derivatives
M8970_RS18110	COG3621	Patatin-like phospholipase
M8970_RS18120	COG0662	Cupin 2, conserved barrel domain protein
M8970_RS18135	COG0277	FAD linked oxidase domain protein
M8970_RS18160	COG0662	Cupin 2, conserved barrel domain protein
M8970_RS18165	COG2318	DinB family
M8970_RS18195	COG1064	alcohol dehydrogenase
M8970_RS18200	COG0789	Transcriptional regulator
M8970_RS18210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS18220	COG2814	Major facilitator Superfamily
M8970_RS18225	COG1309	transcriptional regulator
M8970_RS18230	COG0697	spore germination
M8970_RS18235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8970_RS18240	COG5577	PFAM Coat F domain
M8970_RS18250	COG1063	alcohol dehydrogenase
M8970_RS18255	COG5577	PFAM Coat F domain
M8970_RS18265	COG4585	Histidine kinase
M8970_RS18270	COG2197	response regulator
M8970_RS18275	COG2409	Drug exporters of the RND superfamily
M8970_RS18280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M8970_RS18285	COG0488	(ABC) transporter
M8970_RS18290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8970_RS18295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8970_RS18305	COG2814	Major facilitator Superfamily
M8970_RS18310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8970_RS18320	COG0730	response to heat
M8970_RS18325	COG0456	acetyltransferase
M8970_RS18330	COG0789	Transcriptional regulator
M8970_RS18330	COG4978	Transcriptional regulator
M8970_RS18335	COG0697	spore germination
M8970_RS18340	COG1051	belongs to the nudix hydrolase family
M8970_RS18345	COG2226	methyltransferase
M8970_RS18350	COG0473	3-isopropylmalate dehydrogenase activity
M8970_RS18355	COG1802	Transcriptional regulator
M8970_RS18360	COG1819	glycosyl
M8970_RS18375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8970_RS18385	COG1388	LysM domain
M8970_RS18390	COG2814	Major facilitator Superfamily
M8970_RS18395	COG2188	Transcriptional regulator
M8970_RS18400	COG2186	Transcriptional regulator
M8970_RS18405	COG2807	transmembrane transport
M8970_RS18410	COG2076	Multidrug Resistance protein
M8970_RS18415	COG2076	Multidrug Resistance protein
M8970_RS18420	COG1309	transcriptional regulator
M8970_RS18425	COG0531	amino acid
M8970_RS18435	COG3832	glyoxalase III activity
M8970_RS18440	COG0604	alcohol dehydrogenase
M8970_RS18445	COG2814	Major facilitator Superfamily
M8970_RS18465	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M8970_RS18470	COG3853	Toxic anion resistance protein (TelA)
M8970_RS18475	COG1982	Orn Lys Arg decarboxylase major
M8970_RS18485	COG3870	Protein conserved in bacteria
M8970_RS18490	COG1728	Protein conserved in bacteria
M8970_RS18495	COG0470	DNA polymerase III
M8970_RS18500	COG1774	PSP1 C-terminal conserved region
M8970_RS18510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M8970_RS18520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M8970_RS18525	COG2002	toxin-antitoxin pair type II binding
M8970_RS18530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8970_RS18530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8970_RS18535	COG0084	hydrolase, TatD family'
M8970_RS18540	COG3583	domain protein
M8970_RS18540	COG3584	3D domain protein
M8970_RS18545	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8970_RS18550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M8970_RS18560	COG4466	Protein conserved in bacteria
M8970_RS18575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8970_RS18580	COG0251	oxidation-reduction process
M8970_RS18595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M8970_RS18615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M8970_RS18620	COG2002	toxin-antitoxin pair type II binding
M8970_RS18625	COG2244	polysaccharide biosynthetic process
M8970_RS18630	COG3956	TIGRFAM MazG family protein
M8970_RS18635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M8970_RS18650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M8970_RS18655	COG1098	S1 RNA binding domain
M8970_RS18670	COG2208	phosphoserine phosphatase activity
M8970_RS18675	COG2304	oxidoreductase activity
M8970_RS18680	COG0515	serine threonine protein kinase
M8970_RS18685	COG0037	tRNA processing
M8970_RS18690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M8970_RS18695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M8970_RS18710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8970_RS18715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8970_RS18720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8970_RS18725	COG0512	Glutamine amidotransferase of anthranilate synthase
M8970_RS18730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8970_RS18735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M8970_RS18740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M8970_RS18745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M8970_RS18750	COG1396	sequence-specific DNA binding
M8970_RS18755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8970_RS18760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M8970_RS18765	COG0726	polysaccharide deacetylase
M8970_RS18770	COG2194	sulfuric ester hydrolase activity
M8970_RS18780	COG0489	protein tyrosine kinase activity
M8970_RS18785	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8970_RS18795	COG2318	DinB family
M8970_RS18800	COG2226	methyltransferase
M8970_RS18820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8970_RS18825	COG1122	ATPase activity
M8970_RS18830	COG1122	ATPase activity
M8970_RS18855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M8970_RS18870	COG0024	Methionine aminopeptidase
M8970_RS18880	COG0201	protein transport
M8970_RS18895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M8970_RS18990	COG0596	Alpha beta hydrolase
M8970_RS19015	COG1358	cellular component organization or biogenesis
M8970_RS19030	COG2813	Specifically methylates the guanine in position
M8970_RS19055	COG0250	Participates in transcription elongation, termination and antitermination
M8970_RS19060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8970_RS19070	COG1595	DNA-templated transcription, initiation
M8970_RS19075	COG3688	RNA-binding protein containing a PIN domain
M8970_RS19080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8970_RS19085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M8970_RS19095	COG1045	serine acetyltransferase
M8970_RS19115	COG4956	integral membrane protein (PIN domain superfamily)
M8970_RS19120	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M8970_RS19125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M8970_RS19130	COG0542	response to heat
M8970_RS19140	COG3880	PFAM UvrB UvrC protein
M8970_RS19145	COG4463	regulation of RNA biosynthetic process
M8970_RS19160	COG0517	IMP dehydrogenase activity
M8970_RS19160	COG0516	GMP reductase activity
M8970_RS19165	COG1686	Belongs to the peptidase S11 family
M8970_RS19185	COG1929	Belongs to the glycerate kinase type-1 family
M8970_RS19195	COG1428	Deoxynucleoside kinase
M8970_RS19200	COG1428	Deoxynucleoside kinase
M8970_RS19205	COG1388	LysM domain
M8970_RS19205	COG3858	chitin binding
M8970_RS19210	COG1335	isochorismatase
M8970_RS19215	COG0590	tRNA wobble adenosine to inosine editing
M8970_RS19225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M8970_RS19230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M8970_RS19235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO