locus-tag	class	description
M8969_RS00015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M8969_RS00020	COG0802	atpase or kinase
M8969_RS00025	COG1214	PFAM Peptidase M22, glycoprotease
M8969_RS00030	COG0456	acetyltransferase
M8969_RS00035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M8969_RS00040	COG0488	(ABC) transporter
M8969_RS00055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8969_RS00060	COG0805	protein transport
M8969_RS00070	COG1266	CAAX protease self-immunity
M8969_RS00115	COG0457	Tetratricopeptide repeat
M8969_RS00120	COG1063	alcohol dehydrogenase
M8969_RS00125	COG2211	Major facilitator Superfamily
M8969_RS00130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8969_RS00140	COG1842	Phage shock protein A
M8969_RS00145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8969_RS00150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M8969_RS00155	COG4260	virion core protein, lumpy skin disease virus
M8969_RS00160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M8969_RS00160	COG2755	lipolytic protein G-D-S-L family
M8969_RS00170	COG1595	DNA-templated transcription, initiation
M8969_RS00175	COG1063	alcohol dehydrogenase
M8969_RS00180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8969_RS00185	COG0823	Involved in the tonB-independent uptake of proteins
M8969_RS00195	COG2132	Multicopper oxidase
M8969_RS00200	COG1113	amino acid transport
M8969_RS00205	COG0714	Associated with various cellular activities
M8969_RS00210	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M8969_RS00215	COG1305	Transglutaminase-like
M8969_RS00240	COG2252	PERMEase
M8969_RS00245	COG3064	Membrane
M8969_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M8969_RS00270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M8969_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M8969_RS00280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M8969_RS00285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8969_RS00300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M8969_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M8969_RS00315	COG0138	bifunctional purine biosynthesis protein purh
M8969_RS00320	COG0151	Belongs to the GarS family
M8969_RS00330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M8969_RS00335	COG1470	cell adhesion involved in biofilm formation
M8969_RS00340	COG4496	protein, YerC YecD
M8969_RS00345	COG0069	glutamate synthase activity
M8969_RS00355	COG0210	DNA helicase
M8969_RS00365	COG4851	CamS sex pheromone cAM373 precursor
M8969_RS00370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8969_RS00375	COG1285	pathogenesis
M8969_RS00380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8969_RS00400	COG1309	transcriptional regulator
M8969_RS00405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8969_RS00410	COG1597	lipid kinase activity
M8969_RS00415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8969_RS00425	COG1131	(ABC) transporter
M8969_RS00465	COG5444	nuclease activity
M8969_RS00495	COG3546	catalase activity
M8969_RS00500	COG0454	-acetyltransferase
M8969_RS00510	COG2323	membrane
M8969_RS00515	COG2329	Antibiotic biosynthesis monooxygenase
M8969_RS00520	COG0346	lactoylglutathione lyase activity
M8969_RS00525	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS00530	COG5583	Uncharacterized small protein (DUF2292)
M8969_RS00535	COG0196	riboflavin kinase activity
M8969_RS00540	COG0670	Belongs to the BI1 family
M8969_RS00545	COG1846	Transcriptional regulator
M8969_RS00550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8969_RS00560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8969_RS00560	COG2124	cytochrome p450
M8969_RS00565	COG1368	sulfuric ester hydrolase activity
M8969_RS00570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M8969_RS00575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS00580	COG1442	glycosyl transferase family 8
M8969_RS00585	COG1216	Glycosyl transferase, family 2
M8969_RS00590	COG1442	glycosyl transferase family 8
M8969_RS00595	COG2223	nitrite transmembrane transporter activity
M8969_RS00600	COG0531	amino acid
M8969_RS00605	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS00610	COG0840	transmembrane signaling receptor activity
M8969_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS00620	COG0463	Glycosyl transferase, family 2
M8969_RS00620	COG0457	Tetratricopeptide repeat
M8969_RS00625	COG0488	(ABC) transporter
M8969_RS00630	COG0789	Transcriptional regulator
M8969_RS00635	COG2814	Major facilitator Superfamily
M8969_RS00640	COG0488	(ABC) transporter
M8969_RS00645	COG0513	Belongs to the DEAD box helicase family
M8969_RS00650	COG0456	acetyltransferase
M8969_RS00655	COG2130	NADP-dependent
M8969_RS00670	COG3866	Pectate lyase
M8969_RS00675	COG0471	metal ion transport
M8969_RS00705	COG3290	protein histidine kinase activity
M8969_RS00710	COG4565	transcriptional regulatory protein
M8969_RS00715	COG3181	Tripartite tricarboxylate transporter family receptor
M8969_RS00720	COG2851	Citrate transporter
M8969_RS00725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS00730	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M8969_RS00740	COG2258	MOSC domain
M8969_RS00760	COG0024	Methionine aminopeptidase
M8969_RS00765	COG1263	PTS System
M8969_RS00765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS00775	COG1368	sulfuric ester hydrolase activity
M8969_RS00785	COG0071	Belongs to the small heat shock protein (HSP20) family
M8969_RS00800	COG1263	PTS System
M8969_RS00800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS00805	COG0366	Alpha amylase catalytic
M8969_RS00810	COG2188	Transcriptional regulator
M8969_RS00815	COG0778	Nitroreductase
M8969_RS00830	COG0737	Belongs to the 5'-nucleotidase family
M8969_RS00835	COG0693	protein deglycase activity
M8969_RS00840	COG1609	Transcriptional regulator
M8969_RS00855	COG2814	Major facilitator Superfamily
M8969_RS00865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8969_RS00870	COG4980	gas vesicle protein
M8969_RS00875	COG1295	ribonuclease BN
M8969_RS00880	COG0477	Major facilitator Superfamily
M8969_RS00885	COG0387	Pfam Sodium calcium exchanger
M8969_RS00895	COG0668	transmembrane transport
M8969_RS00900	COG0535	radical SAM domain protein
M8969_RS00910	COG0726	polysaccharide deacetylase
M8969_RS00930	COG0745	RESPONSE REGULATOR receiver
M8969_RS00935	COG2205	protein histidine kinase activity
M8969_RS00940	COG2084	Dehydrogenase
M8969_RS00950	COG0598	Magnesium transport protein CorA
M8969_RS00955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M8969_RS00960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8969_RS00975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8969_RS00980	COG4637	Psort location Cytoplasmic, score
M8969_RS00985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8969_RS00990	COG0022	dehydrogenase e1 component
M8969_RS00995	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8969_RS01000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8969_RS01005	COG3284	Transcriptional regulator
M8969_RS01015	COG1486	melibiose metabolic process
M8969_RS01020	COG1737	Transcriptional regulator
M8969_RS01025	COG1263	PTS System
M8969_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS01030	COG5434	Belongs to the glycosyl hydrolase 28 family
M8969_RS01035	COG5434	Belongs to the glycosyl hydrolase 28 family
M8969_RS01040	COG1132	(ABC) transporter
M8969_RS01045	COG1132	(ABC) transporter
M8969_RS01050	COG2259	Doxx family
M8969_RS01055	COG2514	catechol 2,3-dioxygenase activity
M8969_RS01070	COG1695	Transcriptional regulator
M8969_RS01075	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8969_RS01080	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M8969_RS01085	COG0574	Belongs to the PEP-utilizing enzyme family
M8969_RS01085	COG3848	Pyruvate phosphate dikinase
M8969_RS01090	COG2732	(Barnase) inhibitor
M8969_RS01095	COG2318	DinB family
M8969_RS01100	COG2814	Major facilitator Superfamily
M8969_RS01105	COG1846	Transcriptional regulator
M8969_RS01110	COG0392	lysyltransferase activity
M8969_RS01110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M8969_RS01115	COG0384	phenazine biosynthesis protein PhzF
M8969_RS01120	COG0778	Nitroreductase
M8969_RS01135	COG1090	epimerase
M8969_RS01150	COG2814	Major facilitator Superfamily
M8969_RS01160	COG3591	Belongs to the peptidase S1B family
M8969_RS01175	COG3103	Sh3 type 3 domain protein
M8969_RS01180	COG5658	integral membrane protein
M8969_RS01185	COG0596	Alpha beta hydrolase
M8969_RS01190	COG0463	Glycosyl transferase, family 2
M8969_RS01195	COG4485	Bacterial membrane protein, YfhO
M8969_RS01200	COG1988	membrane-bound metal-dependent
M8969_RS01205	COG1194	a g-specific adenine glycosylase
M8969_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS01235	COG1132	(ABC) transporter
M8969_RS01240	COG4129	membrane
M8969_RS01250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M8969_RS01255	COG0735	belongs to the Fur family
M8969_RS01275	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M8969_RS01280	COG3853	Toxic anion resistance protein (TelA)
M8969_RS01285	COG1982	Orn Lys Arg decarboxylase major
M8969_RS01295	COG3870	Protein conserved in bacteria
M8969_RS01300	COG1728	Protein conserved in bacteria
M8969_RS01305	COG0470	DNA polymerase III
M8969_RS01310	COG1774	PSP1 C-terminal conserved region
M8969_RS01320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M8969_RS01330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M8969_RS01335	COG2002	toxin-antitoxin pair type II binding
M8969_RS01340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8969_RS01340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8969_RS01345	COG0084	hydrolase, TatD family'
M8969_RS01350	COG3584	3D domain protein
M8969_RS01350	COG3583	domain protein
M8969_RS01355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8969_RS01360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M8969_RS01370	COG4466	Protein conserved in bacteria
M8969_RS01385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8969_RS01390	COG0251	oxidation-reduction process
M8969_RS01405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M8969_RS01425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M8969_RS01430	COG2002	toxin-antitoxin pair type II binding
M8969_RS01435	COG2244	polysaccharide biosynthetic process
M8969_RS01440	COG3956	TIGRFAM MazG family protein
M8969_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M8969_RS01460	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M8969_RS01465	COG1098	S1 RNA binding domain
M8969_RS01480	COG2208	phosphoserine phosphatase activity
M8969_RS01485	COG2304	oxidoreductase activity
M8969_RS01490	COG0515	serine threonine protein kinase
M8969_RS01495	COG0037	tRNA processing
M8969_RS01500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M8969_RS01505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M8969_RS01520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8969_RS01525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8969_RS01530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8969_RS01535	COG0512	Glutamine amidotransferase of anthranilate synthase
M8969_RS01540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8969_RS01545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M8969_RS01550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M8969_RS01555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M8969_RS01560	COG1396	sequence-specific DNA binding
M8969_RS01565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8969_RS01570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M8969_RS01575	COG0738	Major facilitator superfamily
M8969_RS01580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8969_RS01590	COG1063	alcohol dehydrogenase
M8969_RS01595	COG0659	secondary active sulfate transmembrane transporter activity
M8969_RS01600	COG0385	Bile acid
M8969_RS01605	COG2819	hydrolase of the alpha beta superfamily
M8969_RS01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS01615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS01620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8969_RS01625	COG2207	Transcriptional regulator
M8969_RS01625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8969_RS01630	COG3876	Protein conserved in bacteria
M8969_RS01635	COG1472	Belongs to the glycosyl hydrolase 3 family
M8969_RS01640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8969_RS01645	COG1263	PTS System
M8969_RS01645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS01655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8969_RS01660	COG1683	Conserved Protein
M8969_RS01690	COG1595	DNA-templated transcription, initiation
M8969_RS01695	COG5662	AntiSigma factor
M8969_RS01700	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8969_RS01705	COG4856	YbbR-like protein
M8969_RS01740	COG5002	protein histidine kinase activity
M8969_RS01745	COG1136	(ABC) transporter
M8969_RS01750	COG0577	efflux transmembrane transporter activity
M8969_RS01755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8969_RS01770	COG1346	cytolysis
M8969_RS01775	COG1380	Effector of murein hydrolase LrgA
M8969_RS01780	COG1846	Transcriptional regulator
M8969_RS01785	COG1113	amino acid transport
M8969_RS01790	COG1011	Hydrolase
M8969_RS01795	COG4585	Histidine kinase
M8969_RS01800	COG2197	response regulator
M8969_RS01805	COG1131	(ABC) transporter
M8969_RS01845	COG0531	amino acid
M8969_RS01850	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8969_RS01865	COG0584	glycerophosphoryl diester phosphodiesterase
M8969_RS01870	COG2271	Major facilitator Superfamily
M8969_RS01880	COG2368	4-hydroxyphenylacetate
M8969_RS01890	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS01905	COG1397	ADP-ribosylglycohydrolase
M8969_RS01910	COG5444	nuclease activity
M8969_RS01920	COG0371	Dehydrogenase
M8969_RS01930	COG1183	phosphatidylcholine synthase activity
M8969_RS01935	COG0586	Pfam SNARE associated Golgi protein
M8969_RS01940	COG0688	phosphatidylethanolamine metabolic process
M8969_RS01955	COG1301	dicarboxylic acid transport
M8969_RS01960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8969_RS01965	COG0833	amino acid
M8969_RS01970	COG2040	homocysteine
M8969_RS01975	COG1115	amino acid carrier protein
M8969_RS01980	COG2066	Belongs to the glutaminase family
M8969_RS01985	COG4191	Histidine kinase
M8969_RS01990	COG0784	Response regulator, receiver
M8969_RS02010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8969_RS02015	COG0778	Nitroreductase
M8969_RS02020	COG0346	lactoylglutathione lyase activity
M8969_RS02025	COG2259	Doxx family
M8969_RS02030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS02045	COG3773	Cell wall hydrolase
M8969_RS02050	COG3540	Alkaline phosphatase
M8969_RS02055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8969_RS02060	COG0805	protein transport
M8969_RS02070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8969_RS02075	COG0477	Major facilitator Superfamily
M8969_RS02080	COG1309	transcriptional regulator
M8969_RS02085	COG0252	asparaginase activity
M8969_RS02090	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M8969_RS02095	COG1405	negative regulation of cell septum assembly
M8969_RS02095	COG3012	SEC-C Motif Domain Protein
M8969_RS02110	COG1595	DNA-templated transcription, initiation
M8969_RS02115	COG1595	DNA-templated transcription, initiation
M8969_RS02120	COG1876	peptidase activity
M8969_RS02125	COG0457	Tetratricopeptide repeat
M8969_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS02135	COG0366	Alpha amylase catalytic
M8969_RS02140	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8969_RS02145	COG1121	(ABC) transporter
M8969_RS02150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8969_RS02155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS02160	COG2310	stress, protein
M8969_RS02165	COG2310	stress, protein
M8969_RS02170	COG2310	stress, protein
M8969_RS02175	COG0861	Integral membrane protein TerC family
M8969_RS02185	COG3853	Toxic anion resistance protein (TelA)
M8969_RS02190	COG0477	Major facilitator Superfamily
M8969_RS02195	COG0517	IMP dehydrogenase activity
M8969_RS02195	COG4175	Glycine betaine
M8969_RS02200	COG4176	ABC-type proline glycine betaine transport system permease component
M8969_RS02205	COG2113	Glycine betaine
M8969_RS02210	COG1473	amidohydrolase
M8969_RS02215	COG1288	antiporter activity
M8969_RS02235	COG2814	Major facilitator Superfamily
M8969_RS02240	COG1846	Transcriptional regulator
M8969_RS02245	COG1280	lysine exporter protein (LysE YggA)
M8969_RS02250	COG3403	YqcI/YcgG family
M8969_RS02255	COG1113	amino acid transport
M8969_RS02260	COG3665	Urea carboxylase-associated protein
M8969_RS02275	COG1660	Displays ATPase and GTPase activities
M8969_RS02280	COG1082	Xylose isomerase domain protein TIM barrel
M8969_RS02285	COG2271	Major facilitator Superfamily
M8969_RS02290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M8969_RS02295	COG3458	cephalosporin-C deacetylase activity
M8969_RS02300	COG3541	Predicted nucleotidyltransferase
M8969_RS02305	COG0506	proline dehydrogenase activity
M8969_RS02310	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS02315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8969_RS02320	COG2508	Transcriptional regulator
M8969_RS02330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8969_RS02330	COG1587	Uroporphyrinogen-III synthase
M8969_RS02335	COG2146	nitrite reductase [NAD(P)H] activity
M8969_RS02340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8969_RS02345	COG0243	molybdopterin cofactor binding
M8969_RS02350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8969_RS02355	COG2223	nitrite transmembrane transporter activity
M8969_RS02360	COG0523	cobalamin synthesis protein
M8969_RS02365	COG1063	alcohol dehydrogenase
M8969_RS02370	COG1714	RDD family
M8969_RS02390	COG3209	COG3209 Rhs family protein
M8969_RS02395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M8969_RS02400	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M8969_RS02405	COG1733	regulation of RNA biosynthetic process
M8969_RS02410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS02430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS02435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS02440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M8969_RS02455	COG2364	Membrane
M8969_RS02460	COG1126	abc transporter atp-binding protein
M8969_RS02465	COG0765	amino acid transport
M8969_RS02475	COG0583	DNA-binding transcription factor activity
M8969_RS02480	COG0163	prenyltransferase activity
M8969_RS02485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M8969_RS02500	COG3104	oligopeptide transport
M8969_RS02505	COG5434	Belongs to the glycosyl hydrolase 28 family
M8969_RS02515	COG0697	spore germination
M8969_RS02525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8969_RS02530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS02535	COG0456	acetyltransferase
M8969_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8969_RS02545	COG0765	amino acid transport
M8969_RS02550	COG1126	abc transporter atp-binding protein
M8969_RS02555	COG1473	amidohydrolase
M8969_RS02560	COG2079	MmgE PrpD family protein
M8969_RS02565	COG1136	(ABC) transporter
M8969_RS02570	COG0577	efflux transmembrane transporter activity
M8969_RS02575	COG0745	RESPONSE REGULATOR receiver
M8969_RS02580	COG5002	protein histidine kinase activity
M8969_RS02580	COG3850	Histidine kinase
M8969_RS02585	COG0457	Tetratricopeptide repeat
M8969_RS02600	COG0527	aspartate kinase activity
M8969_RS02605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS02610	COG4605	iron ion homeostasis
M8969_RS02615	COG4604	ABC transporter, ATP-binding protein
M8969_RS02620	COG4607	ABC-type enterochelin transport system periplasmic component
M8969_RS02625	COG2814	Major facilitator Superfamily
M8969_RS02630	COG1309	transcriptional regulator
M8969_RS02635	COG0778	Nitroreductase
M8969_RS02640	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8969_RS02645	COG0640	Transcriptional regulator
M8969_RS02650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS02655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8969_RS02660	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS02665	COG4975	Glucose uptake
M8969_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS02675	COG4549	nuclear export factor GLE1
M8969_RS02680	COG1276	copper resistance
M8969_RS02680	COG2372	response to copper ion
M8969_RS02685	COG1349	DNA-binding transcription factor activity
M8969_RS02695	COG2213	PTS system mannitol-specific
M8969_RS02700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS02710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M8969_RS02720	COG0561	phosphatase activity
M8969_RS02730	COG1914	H( )-stimulated, divalent metal cation uptake system
M8969_RS02740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8969_RS02745	COG1984	allophanate hydrolase subunit 2
M8969_RS02750	COG1414	Transcriptional regulator
M8969_RS02755	COG2755	lipolytic protein G-D-S-L family
M8969_RS02765	COG2329	Antibiotic biosynthesis monooxygenase
M8969_RS02770	COG0768	penicillin binding
M8969_RS02775	COG4989	oxidoreductase activity
M8969_RS02780	COG3711	transcriptional antiterminator
M8969_RS02785	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS02795	COG1917	Cupin 2, conserved barrel domain protein
M8969_RS02800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8969_RS02805	COG3871	stress protein (general stress protein 26)
M8969_RS02815	COG2814	Major facilitator Superfamily
M8969_RS02820	COG1522	sequence-specific DNA binding
M8969_RS02825	COG0551	DNA topoisomerase type I activity
M8969_RS02825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8969_RS02830	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M8969_RS02835	COG3706	GGDEF domain
M8969_RS02840	COG5298	Protein conserved in bacteria
M8969_RS02845	COG1215	transferase activity, transferring glycosyl groups
M8969_RS02855	COG0531	amino acid
M8969_RS02865	COG0028	Belongs to the TPP enzyme family
M8969_RS02870	COG1388	LysM domain
M8969_RS02870	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS02870	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8969_RS02890	COG0457	Tetratricopeptide repeat
M8969_RS02915	COG1914	H( )-stimulated, divalent metal cation uptake system
M8969_RS02935	COG2076	Multidrug Resistance protein
M8969_RS02940	COG2217	Heavy metal translocating P-type atpase
M8969_RS02945	COG3729	General stress protein
M8969_RS02950	COG0662	Cupin 2, conserved barrel domain protein
M8969_RS02955	COG2329	Antibiotic biosynthesis monooxygenase
M8969_RS02960	COG3546	catalase activity
M8969_RS02965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M8969_RS02970	COG3290	protein histidine kinase activity
M8969_RS02975	COG4565	transcriptional regulatory protein
M8969_RS02980	COG1301	dicarboxylic acid transport
M8969_RS02985	COG0628	permease
M8969_RS02990	COG1131	(ABC) transporter
M8969_RS02995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8969_RS03005	COG1960	acyl-CoA dehydrogenase activity
M8969_RS03020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8969_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS03035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M8969_RS03040	COG0513	Belongs to the DEAD box helicase family
M8969_RS03045	COG3402	PFAM membrane-flanked domain
M8969_RS03050	COG3428	Bacterial PH domain
M8969_RS03055	COG0705	Rhomboid family
M8969_RS03065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M8969_RS03070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8969_RS03075	COG0864	Transcriptional regulator
M8969_RS03080	COG2337	Toxic component of a toxin-antitoxin (TA) module
M8969_RS03085	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS03090	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS03095	COG2172	sigma factor antagonist activity
M8969_RS03100	COG2208	phosphoserine phosphatase activity
M8969_RS03105	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS03115	COG1191	sigma factor activity
M8969_RS03120	COG2208	phosphoserine phosphatase activity
M8969_RS03125	COG2183	response to ionizing radiation
M8969_RS03190	COG5444	nuclease activity
M8969_RS03210	COG0477	Major facilitator Superfamily
M8969_RS03225	COG2030	dehydratase
M8969_RS03235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8969_RS03240	COG1959	2 iron, 2 sulfur cluster binding
M8969_RS03245	COG2910	NAD(P)H-binding
M8969_RS03250	COG3239	Fatty acid desaturase
M8969_RS03255	COG1278	Cold shock
M8969_RS03260	COG1329	Transcriptional regulator
M8969_RS03265	COG1937	Protein conserved in bacteria
M8969_RS03270	COG2210	Belongs to the sulfur carrier protein TusA family
M8969_RS03275	COG1054	Belongs to the UPF0176 family
M8969_RS03280	COG0425	Belongs to the sulfur carrier protein TusA family
M8969_RS03280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8969_RS03290	COG0425	Belongs to the sulfur carrier protein TusA family
M8969_RS03295	COG0730	response to heat
M8969_RS03300	COG1794	racemase activity, acting on amino acids and derivatives
M8969_RS03315	COG3621	Patatin-like phospholipase
M8969_RS03325	COG0662	Cupin 2, conserved barrel domain protein
M8969_RS03340	COG0277	FAD linked oxidase domain protein
M8969_RS03365	COG0662	Cupin 2, conserved barrel domain protein
M8969_RS03370	COG2318	DinB family
M8969_RS03400	COG1064	alcohol dehydrogenase
M8969_RS03405	COG0789	Transcriptional regulator
M8969_RS03415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS03425	COG2814	Major facilitator Superfamily
M8969_RS03430	COG1309	transcriptional regulator
M8969_RS03435	COG0697	spore germination
M8969_RS03440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS03445	COG5577	PFAM Coat F domain
M8969_RS03455	COG1063	alcohol dehydrogenase
M8969_RS03460	COG5577	PFAM Coat F domain
M8969_RS03470	COG4585	Histidine kinase
M8969_RS03475	COG2197	response regulator
M8969_RS03480	COG2409	Drug exporters of the RND superfamily
M8969_RS03485	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M8969_RS03490	COG0488	(ABC) transporter
M8969_RS03495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8969_RS03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS03510	COG2814	Major facilitator Superfamily
M8969_RS03515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8969_RS03525	COG0730	response to heat
M8969_RS03530	COG0456	acetyltransferase
M8969_RS03535	COG0789	Transcriptional regulator
M8969_RS03535	COG4978	Transcriptional regulator
M8969_RS03540	COG0697	spore germination
M8969_RS03545	COG1051	belongs to the nudix hydrolase family
M8969_RS03550	COG2226	methyltransferase
M8969_RS03555	COG0473	3-isopropylmalate dehydrogenase activity
M8969_RS03560	COG1802	Transcriptional regulator
M8969_RS03565	COG1819	glycosyl
M8969_RS03580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8969_RS03590	COG1388	LysM domain
M8969_RS03595	COG2814	Major facilitator Superfamily
M8969_RS03600	COG2188	Transcriptional regulator
M8969_RS03605	COG2186	Transcriptional regulator
M8969_RS03610	COG2807	transmembrane transport
M8969_RS03615	COG2076	Multidrug Resistance protein
M8969_RS03620	COG2076	Multidrug Resistance protein
M8969_RS03625	COG1309	transcriptional regulator
M8969_RS03630	COG0531	amino acid
M8969_RS03640	COG3832	glyoxalase III activity
M8969_RS03645	COG0604	alcohol dehydrogenase
M8969_RS03650	COG2814	Major facilitator Superfamily
M8969_RS03685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8969_RS03690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M8969_RS03695	COG0753	catalase activity
M8969_RS03705	COG1482	cell wall glycoprotein biosynthetic process
M8969_RS03715	COG2723	6-phospho-beta-galactosidase activity
M8969_RS03720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS03725	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8969_RS03730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS03735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8969_RS03740	COG0640	Transcriptional regulator
M8969_RS03750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS03755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS03765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS03765	COG3711	transcriptional antiterminator
M8969_RS03770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS03775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS03780	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8969_RS03785	COG1486	melibiose metabolic process
M8969_RS03790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8969_RS03795	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M8969_RS03805	COG1696	Membrane protein involved in D-alanine export
M8969_RS03820	COG1575	Belongs to the MenA family. Type 1 subfamily
M8969_RS03825	COG2357	RelA SpoT domain protein
M8969_RS03830	COG1442	glycosyl transferase family 8
M8969_RS03835	COG1404	Belongs to the peptidase S8 family
M8969_RS03840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS03845	COG0346	lactoylglutathione lyase activity
M8969_RS03850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M8969_RS03855	COG5504	Zn-dependent protease
M8969_RS03860	COG0789	Transcriptional regulator
M8969_RS03865	COG4895	conserved protein (DUF2196)
M8969_RS03870	COG1346	cytolysis
M8969_RS03880	COG0583	DNA-binding transcription factor activity
M8969_RS03900	COG2837	iron assimilation
M8969_RS03905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8969_RS03925	COG1309	transcriptional regulator
M8969_RS03930	COG2246	polysaccharide biosynthetic process
M8969_RS03935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8969_RS03940	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8969_RS03945	COG2261	transglycosylase associated protein
M8969_RS03950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8969_RS03955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8969_RS03975	COG0454	-acetyltransferase
M8969_RS03980	COG0772	Belongs to the SEDS family
M8969_RS03985	COG0778	Nitroreductase
M8969_RS03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS03995	COG1404	Belongs to the peptidase S8 family
M8969_RS04005	COG3711	transcriptional antiterminator
M8969_RS04010	COG1263	PTS System
M8969_RS04010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS04015	COG1621	beta-fructofuranosidase activity
M8969_RS04025	COG0351	phosphomethylpyrimidine kinase
M8969_RS04030	COG1695	Transcriptional regulator
M8969_RS04045	COG1216	Glycosyl transferase, family 2
M8969_RS04060	COG2233	PERMEase
M8969_RS04065	COG2363	Small membrane protein
M8969_RS04075	COG0463	Glycosyl transferase, family 2
M8969_RS04080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8969_RS04085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8969_RS04090	COG0456	acetyltransferase
M8969_RS04095	COG2089	acid synthase
M8969_RS04100	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M8969_RS04105	COG3980	spore coat polysaccharide biosynthesis protein
M8969_RS04110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M8969_RS04115	COG1088	dTDP-glucose 4,6-dehydratase activity
M8969_RS04120	COG1091	dTDP-4-dehydrorhamnose reductase activity
M8969_RS04125	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M8969_RS04130	COG1131	(ABC) transporter
M8969_RS04145	COG0745	RESPONSE REGULATOR receiver
M8969_RS04150	COG2205	protein histidine kinase activity
M8969_RS04155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8969_RS04160	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS04165	COG4187	Peptidase family M20/M25/M40
M8969_RS04170	COG0833	amino acid
M8969_RS04175	COG2814	Major facilitator Superfamily
M8969_RS04180	COG2814	Major facilitator Superfamily
M8969_RS04210	COG0436	Aminotransferase
M8969_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS04225	COG0280	phosphate acetyltransferase
M8969_RS04230	COG2855	membrane
M8969_RS04235	COG0583	DNA-binding transcription factor activity
M8969_RS04265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8969_RS04270	COG1131	(ABC) transporter
M8969_RS04280	COG1695	Transcriptional regulator
M8969_RS04295	COG1078	dGTPase activity
M8969_RS04300	COG3465	dGTPase activity
M8969_RS04305	COG0531	amino acid
M8969_RS04310	COG1846	Transcriptional regulator
M8969_RS04315	COG1942	4-Oxalocrotonate Tautomerase
M8969_RS04320	COG1994	Peptidase M50
M8969_RS04335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8969_RS04340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M8969_RS04345	COG0010	Belongs to the arginase family
M8969_RS04355	COG0457	Tetratricopeptide repeat
M8969_RS04360	COG3391	amine dehydrogenase activity
M8969_RS04365	COG3391	amine dehydrogenase activity
M8969_RS04375	COG4506	Protein conserved in bacteria
M8969_RS04385	COG2223	nitrite transmembrane transporter activity
M8969_RS04390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8969_RS04400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8969_RS04405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M8969_RS04410	COG1140	nitrate reductase beta subunit
M8969_RS04415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M8969_RS04420	COG2181	nitrate reductase activity
M8969_RS04430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8969_RS04435	COG1132	(ABC) transporter
M8969_RS04450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8969_RS04455	COG0247	lactate metabolic process
M8969_RS04455	COG2181	nitrate reductase activity
M8969_RS04470	COG4821	SIS domain
M8969_RS04475	COG2204	response regulator
M8969_RS04480	COG0191	fructose-bisphosphate aldolase activity
M8969_RS04490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8969_RS04495	COG1494	fructose-1,6-bisphosphatase
M8969_RS04505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M8969_RS04520	COG0281	malic enzyme
M8969_RS04525	COG0679	Auxin Efflux Carrier
M8969_RS04530	COG0789	Transcriptional regulator
M8969_RS04535	COG0346	lactoylglutathione lyase activity
M8969_RS04540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M8969_RS04545	COG2890	protein-(glutamine-N5) methyltransferase activity
M8969_RS04565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M8969_RS04570	COG0009	L-threonylcarbamoyladenylate synthase
M8969_RS04580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8969_RS04585	COG0698	ribose 5-phosphate isomerase
M8969_RS04655	COG4836	Membrane
M8969_RS04665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8969_RS04670	COG2385	sporulation resulting in formation of a cellular spore
M8969_RS04675	COG2304	oxidoreductase activity
M8969_RS04680	COG2304	oxidoreductase activity
M8969_RS04690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M8969_RS04700	COG0457	Tetratricopeptide repeat
M8969_RS04705	COG1994	Peptidase M50
M8969_RS04710	COG3237	CsbD-like
M8969_RS04715	COG0831	urea catabolic process
M8969_RS04730	COG1959	2 iron, 2 sulfur cluster binding
M8969_RS04740	COG0726	polysaccharide deacetylase
M8969_RS04750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8969_RS04765	COG1247	-acetyltransferase
M8969_RS04770	COG0739	heme binding
M8969_RS04780	COG0671	phosphoesterase, PA-phosphatase related
M8969_RS04785	COG0772	Belongs to the SEDS family
M8969_RS04790	COG0347	Belongs to the P(II) protein family
M8969_RS04795	COG0004	ammonium transporteR
M8969_RS04800	COG1335	isochorismatase
M8969_RS04805	COG0477	Major facilitator Superfamily
M8969_RS04810	COG1953	Uracil, thiamine, allantoin
M8969_RS04815	COG2814	Major facilitator Superfamily
M8969_RS04820	COG1846	Transcriptional regulator
M8969_RS04825	COG1609	Transcriptional regulator
M8969_RS04830	COG1077	Cell shape determining protein MreB Mrl
M8969_RS04835	COG4786	Flagellar basal body rod
M8969_RS04840	COG4786	Flagellar basal body rod
M8969_RS04845	COG0457	Tetratricopeptide repeat
M8969_RS04870	COG0629	single-stranded DNA binding
M8969_RS04875	COG1349	DNA-binding transcription factor activity
M8969_RS04880	COG0561	phosphatase activity
M8969_RS04885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8969_RS04890	COG4715	Zinc finger, swim domain protein
M8969_RS04900	COG3944	biosynthesis protein
M8969_RS04905	COG0489	protein tyrosine kinase activity
M8969_RS04910	COG4464	protein tyrosine phosphatase activity
M8969_RS04915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8969_RS04920	COG3878	Protein conserved in bacteria
M8969_RS04935	COG5444	nuclease activity
M8969_RS04965	COG0583	DNA-binding transcription factor activity
M8969_RS04970	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8969_RS04980	COG2059	Chromate
M8969_RS04985	COG2059	Chromate
M8969_RS04990	COG1522	sequence-specific DNA binding
M8969_RS04995	COG0405	Gamma-glutamyltransferase
M8969_RS05005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8969_RS05015	COG5337	Spore coat protein CotH
M8969_RS05030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8969_RS05035	COG0583	DNA-binding transcription factor activity
M8969_RS05040	COG0028	Belongs to the TPP enzyme family
M8969_RS05045	COG3527	Alpha-acetolactate decarboxylase
M8969_RS05050	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8969_RS05055	COG3103	Sh3 type 3 domain protein
M8969_RS05060	COG1879	ABC-type sugar transport system periplasmic component
M8969_RS05065	COG1172	Belongs to the binding-protein-dependent transport system permease family
M8969_RS05070	COG1129	ABC transporter
M8969_RS05080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8969_RS05085	COG1609	Transcriptional regulator
M8969_RS05095	COG0814	amino acid
M8969_RS05100	COG0697	spore germination
M8969_RS05105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8969_RS05115	COG2843	Capsule synthesis protein
M8969_RS05125	COG0791	NLP P60 protein
M8969_RS05130	COG2433	Pfam Transposase IS66
M8969_RS05135	COG0561	phosphatase activity
M8969_RS05140	COG1316	TRANSCRIPTIONal
M8969_RS05145	COG2814	Major facilitator Superfamily
M8969_RS05150	COG1215	transferase activity, transferring glycosyl groups
M8969_RS05160	COG0814	amino acid
M8969_RS05165	COG0697	spore germination
M8969_RS05170	COG1482	cell wall glycoprotein biosynthetic process
M8969_RS05175	COG4193	domain, Protein
M8969_RS05180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8969_RS05185	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M8969_RS05190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M8969_RS05200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8969_RS05205	COG1682	transport, permease protein
M8969_RS05210	COG1134	teichoic acid transport
M8969_RS05215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8969_RS05220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M8969_RS05225	COG1316	TRANSCRIPTIONal
M8969_RS05235	COG2247	cell wall binding repeat
M8969_RS05235	COG2385	sporulation resulting in formation of a cellular spore
M8969_RS05240	COG2247	cell wall binding repeat
M8969_RS05240	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS05250	COG2244	polysaccharide biosynthetic process
M8969_RS05255	COG0297	glycogen (starch) synthase activity
M8969_RS05255	COG0438	transferase activity, transferring glycosyl groups
M8969_RS05260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8969_RS05265	COG3307	-O-antigen
M8969_RS05270	COG3206	protein involved in exopolysaccharide biosynthesis
M8969_RS05275	COG1215	transferase activity, transferring glycosyl groups
M8969_RS05280	COG0438	transferase activity, transferring glycosyl groups
M8969_RS05285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8969_RS05290	COG1316	TRANSCRIPTIONal
M8969_RS05295	COG1739	Uncharacterized protein family UPF0029
M8969_RS05300	COG4585	Histidine kinase
M8969_RS05305	COG2197	response regulator
M8969_RS05310	COG1307	EDD domain protein, DegV family
M8969_RS05315	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M8969_RS05325	COG1040	competence protein
M8969_RS05335	COG2747	anti-sigma28 factor FlgM
M8969_RS05340	COG3418	PFAM FlgN family protein
M8969_RS05345	COG1256	bacterial-type flagellum assembly
M8969_RS05345	COG4786	Flagellar basal body rod
M8969_RS05350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8969_RS05370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8969_RS05375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M8969_RS05380	COG1516	flagellar protein fliS
M8969_RS05395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M8969_RS05410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS05415	COG2010	Cytochrome c
M8969_RS05420	COG2884	Cell division ATP-binding protein ftsE
M8969_RS05425	COG2177	Part of the ABC transporter FtsEX involved in
M8969_RS05430	COG3420	alginic acid biosynthetic process
M8969_RS05435	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS05435	COG0793	Belongs to the peptidase S41A family
M8969_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8969_RS05460	COG2814	Major facilitator Superfamily
M8969_RS05465	COG1309	transcriptional regulator
M8969_RS05470	COG0574	Belongs to the PEP-utilizing enzyme family
M8969_RS05470	COG3848	Pyruvate phosphate dikinase
M8969_RS05475	COG4897	Protein conserved in bacteria
M8969_RS05485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M8969_RS05500	COG3595	metallopeptidase activity
M8969_RS05505	COG1983	PspC domain protein
M8969_RS05510	COG1950	PFAM Membrane protein of
M8969_RS05515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M8969_RS05520	COG1309	transcriptional regulator
M8969_RS05525	COG2188	Transcriptional regulator
M8969_RS05535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M8969_RS05555	COG0110	maltose O-acetyltransferase activity
M8969_RS05560	COG4990	cell redox homeostasis
M8969_RS05575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M8969_RS05600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M8969_RS05600	COG0140	phosphoribosyl-ATP diphosphatase activity
M8969_RS05605	COG1132	(ABC) transporter
M8969_RS05610	COG0745	RESPONSE REGULATOR receiver
M8969_RS05615	COG5002	protein histidine kinase activity
M8969_RS05620	COG0457	Tetratricopeptide repeat
M8969_RS05625	COG0791	NLP P60 protein
M8969_RS05625	COG3883	PFAM NLP P60 protein
M8969_RS05630	COG0492	ferredoxin-NADP+ reductase activity
M8969_RS05635	COG1051	belongs to the nudix hydrolase family
M8969_RS05645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M8969_RS05655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS05660	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M8969_RS05665	COG4290	ribonuclease
M8969_RS05670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8969_RS05675	COG0288	reversible hydration of carbon dioxide
M8969_RS05680	COG0659	secondary active sulfate transmembrane transporter activity
M8969_RS05685	COG1694	Mazg nucleotide pyrophosphohydrolase
M8969_RS05690	COG1611	Belongs to the LOG family
M8969_RS05695	COG1609	Transcriptional regulator
M8969_RS05700	COG0366	Alpha amylase catalytic
M8969_RS05705	COG2182	Extracellular solute-binding protein
M8969_RS05710	COG1175	transmembrane transport
M8969_RS05715	COG3833	ABC-type maltose transport systems, permease component
M8969_RS05720	COG5521	maltodextrose utilization protein MalA
M8969_RS05725	COG1554	hydrolase, family 65, central catalytic
M8969_RS05730	COG0366	Alpha amylase catalytic
M8969_RS05735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8969_RS05745	COG1609	Transcriptional regulator
M8969_RS05750	COG2223	nitrite transmembrane transporter activity
M8969_RS05805	COG3479	Phenolic acid decarboxylase
M8969_RS05810	COG0456	acetyltransferase
M8969_RS05815	COG2364	Membrane
M8969_RS05820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8969_RS05825	COG2272	Belongs to the type-B carboxylesterase lipase family
M8969_RS05830	COG1396	sequence-specific DNA binding
M8969_RS05835	COG3944	biosynthesis protein
M8969_RS05840	COG0489	protein tyrosine kinase activity
M8969_RS05845	COG1086	Polysaccharide biosynthesis protein
M8969_RS05850	COG0438	transferase activity, transferring glycosyl groups
M8969_RS05855	COG1215	transferase activity, transferring glycosyl groups
M8969_RS05860	COG0438	transferase activity, transferring glycosyl groups
M8969_RS05870	COG1216	Glycosyl transferase, family 2
M8969_RS05875	COG5039	Polysaccharide pyruvyl transferase
M8969_RS05880	COG1216	Glycosyl transferase, family 2
M8969_RS05885	COG2244	polysaccharide biosynthetic process
M8969_RS05890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M8969_RS05895	COG0110	maltose O-acetyltransferase activity
M8969_RS05900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8969_RS05905	COG5039	Polysaccharide pyruvyl transferase
M8969_RS05915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M8969_RS05920	COG1620	l-lactate permease
M8969_RS05925	COG2186	Transcriptional regulator
M8969_RS05930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS05970	COG1070	Carbohydrate kinase
M8969_RS05975	COG1737	Transcriptional regulator
M8969_RS05980	COG0561	phosphatase activity
M8969_RS05990	COG1609	Transcriptional regulator
M8969_RS05995	COG1113	amino acid transport
M8969_RS06000	COG0697	spore germination
M8969_RS06005	COG0583	DNA-binding transcription factor activity
M8969_RS06015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS06020	COG1609	Transcriptional regulator
M8969_RS06025	COG2814	Major facilitator Superfamily
M8969_RS06030	COG2390	Transcriptional regulator
M8969_RS06035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8969_RS06040	COG0126	phosphoglycerate kinase activity
M8969_RS06060	COG2234	aminopeptidase activity
M8969_RS06070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8969_RS06075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS06095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8969_RS06110	COG0456	acetyltransferase
M8969_RS06115	COG4640	response to antibiotic
M8969_RS06120	COG3064	Membrane
M8969_RS06125	COG2095	MarC family integral membrane protein
M8969_RS06130	COG1510	regulation of RNA biosynthetic process
M8969_RS06135	COG1125	glycine betaine transport
M8969_RS06135	COG0517	IMP dehydrogenase activity
M8969_RS06140	COG1174	glycine betaine transport
M8969_RS06145	COG1732	Glycine betaine
M8969_RS06150	COG1174	glycine betaine transport
M8969_RS06155	COG1510	regulation of RNA biosynthetic process
M8969_RS06160	COG1125	glycine betaine transport
M8969_RS06160	COG0517	IMP dehydrogenase activity
M8969_RS06165	COG1174	glycine betaine transport
M8969_RS06170	COG1732	Glycine betaine
M8969_RS06175	COG1174	glycine betaine transport
M8969_RS06180	COG1131	(ABC) transporter
M8969_RS06205	COG1733	regulation of RNA biosynthetic process
M8969_RS06210	COG1396	sequence-specific DNA binding
M8969_RS06215	COG1396	sequence-specific DNA binding
M8969_RS06220	COG1476	TRANSCRIPTIONal
M8969_RS06225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8969_RS06230	COG1647	Serine aminopeptidase, S33
M8969_RS06235	COG0557	exoribonuclease II activity
M8969_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS06285	COG0583	DNA-binding transcription factor activity
M8969_RS06290	COG0454	-acetyltransferase
M8969_RS06295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8969_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8969_RS06305	COG0765	amino acid transport
M8969_RS06310	COG0765	amino acid transport
M8969_RS06315	COG1126	abc transporter atp-binding protein
M8969_RS06320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS06325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M8969_RS06330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8969_RS06340	COG0673	inositol 2-dehydrogenase activity
M8969_RS06345	COG1937	Protein conserved in bacteria
M8969_RS06350	COG2608	mercury ion transmembrane transporter activity
M8969_RS06355	COG2217	Heavy metal translocating P-type atpase
M8969_RS06360	COG2217	Heavy metal translocating P-type atpase
M8969_RS06365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M8969_RS06370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M8969_RS06380	COG2860	membrane
M8969_RS06385	COG3973	AAA domain
M8969_RS06390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8969_RS06410	COG0656	L-ascorbic acid biosynthetic process
M8969_RS06415	COG0842	Transport permease protein
M8969_RS06425	COG1131	(ABC) transporter
M8969_RS06430	COG3850	Histidine kinase
M8969_RS06435	COG2197	response regulator
M8969_RS06440	COG4149	molybdate abc transporter
M8969_RS06445	COG0725	ABC transporter, periplasmic molybdate-binding protein
M8969_RS06450	COG1910	domain protein
M8969_RS06455	COG1368	sulfuric ester hydrolase activity
M8969_RS06460	COG1988	membrane-bound metal-dependent
M8969_RS06470	COG0531	amino acid
M8969_RS06475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8969_RS06480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS06485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS06490	COG1120	ATPase activity
M8969_RS06500	COG2140	Oxalate decarboxylase
M8969_RS06510	COG1191	sigma factor activity
M8969_RS06520	COG0745	RESPONSE REGULATOR receiver
M8969_RS06525	COG2205	protein histidine kinase activity
M8969_RS06530	COG3386	PFAM SMP-30 Gluconolaconase
M8969_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS06540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8969_RS06545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8969_RS06550	COG1120	ATPase activity
M8969_RS06555	COG2096	Adenosyltransferase
M8969_RS06560	COG2814	Major facilitator Superfamily
M8969_RS06565	COG4758	membrane
M8969_RS06570	COG1842	Phage shock protein A
M8969_RS06575	COG3595	metallopeptidase activity
M8969_RS06580	COG4758	membrane
M8969_RS06585	COG4585	Histidine kinase
M8969_RS06590	COG2197	response regulator
M8969_RS06600	COG0814	amino acid
M8969_RS06605	COG0697	spore germination
M8969_RS06615	COG0114	fumarate hydratase activity
M8969_RS06620	COG1309	transcriptional regulator
M8969_RS06630	COG2205	protein histidine kinase activity
M8969_RS06630	COG2770	Histidine kinase
M8969_RS06635	COG0745	RESPONSE REGULATOR receiver
M8969_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8969_RS06645	COG0783	Belongs to the Dps family
M8969_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS06665	COG1120	ATPase activity
M8969_RS06685	COG0583	DNA-binding transcription factor activity
M8969_RS06695	COG0583	DNA-binding transcription factor activity
M8969_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS06705	COG1942	4-Oxalocrotonate Tautomerase
M8969_RS06710	COG0477	Major facilitator Superfamily
M8969_RS06715	COG1846	Transcriptional regulator
M8969_RS06720	COG5577	PFAM Coat F domain
M8969_RS06740	COG1024	Enoyl-CoA hydratase
M8969_RS06740	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8969_RS06745	COG0183	Belongs to the thiolase family
M8969_RS06750	COG1960	acyl-CoA dehydrogenase activity
M8969_RS06755	COG1393	Belongs to the ArsC family
M8969_RS06770	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8969_RS06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS06785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8969_RS06790	COG2011	ABC-type metal ion transport system permease component
M8969_RS06795	COG1464	Belongs to the NlpA lipoprotein family
M8969_RS06800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8969_RS06810	COG0396	ATPase activity
M8969_RS06815	COG0719	Fe-S assembly protein
M8969_RS06820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8969_RS06825	COG0822	iron-sulfur transferase activity
M8969_RS06830	COG0719	Fe-S assembly protein
M8969_RS06835	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS06855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8969_RS06860	COG0322	excinuclease ABC activity
M8969_RS06885	COG0789	Transcriptional regulator
M8969_RS06890	COG2222	sugar isomerase
M8969_RS06895	COG1653	transport
M8969_RS06900	COG1175	transmembrane transport
M8969_RS06905	COG0395	ABC-type sugar transport system, permease component
M8969_RS06910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8969_RS06915	COG2188	Transcriptional regulator
M8969_RS06920	COG3842	ATPase activity
M8969_RS06925	COG2356	endonuclease I
M8969_RS06930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8969_RS06935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M8969_RS06940	COG2814	Major facilitator Superfamily
M8969_RS06965	COG2508	Transcriptional regulator
M8969_RS06980	COG1801	Protein of unknown function DUF72
M8969_RS06985	COG0730	response to heat
M8969_RS06990	COG0737	Belongs to the 5'-nucleotidase family
M8969_RS07000	COG0739	heme binding
M8969_RS07010	COG4470	Protein conserved in bacteria
M8969_RS07015	COG2445	Protein of unknown function DUF86
M8969_RS07020	COG0647	UMP catabolic process
M8969_RS07025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M8969_RS07030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8969_RS07035	COG0460	homoserine dehydrogenase
M8969_RS07040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M8969_RS07050	COG0823	Involved in the tonB-independent uptake of proteins
M8969_RS07050	COG1506	peptidase
M8969_RS07050	COG4946	Tricorn protease homolog
M8969_RS07055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M8969_RS07060	COG4837	Protein of unknown function (DUF1462)
M8969_RS07065	COG1252	NADH dehydrogenase
M8969_RS07075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8969_RS07085	COG0316	Belongs to the HesB IscA family
M8969_RS07090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M8969_RS07095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8969_RS07115	COG1131	(ABC) transporter
M8969_RS07145	COG1252	NADH dehydrogenase
M8969_RS07160	COG3584	3D domain protein
M8969_RS07165	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M8969_RS07175	COG2056	Na+-H+ antiporter family
M8969_RS07180	COG1268	BioY protein
M8969_RS07185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8969_RS07190	COG2819	hydrolase of the alpha beta superfamily
M8969_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS07200	COG1169	isochorismate synthase
M8969_RS07205	COG1021	2,3-dihydroxybenzoate-AMP ligase
M8969_RS07210	COG1535	isochorismatase
M8969_RS07210	COG3433	isochorismatase activity
M8969_RS07215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS07220	COG3251	PFAM MbtH domain protein
M8969_RS07225	COG5634	Uncharacterized conserved protein (DUF2278)
M8969_RS07230	COG0686	Belongs to the AlaDH PNT family
M8969_RS07235	COG2508	Transcriptional regulator
M8969_RS07235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M8969_RS07240	COG4842	Belongs to the WXG100 family
M8969_RS07245	COG5417	Belongs to the EsaB family
M8969_RS07250	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8969_RS07255	COG0433	COG0433 Predicted ATPase
M8969_RS07255	COG1674	ftsk spoiiie
M8969_RS07260	COG1511	domain protein
M8969_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS07275	COG1418	mRNA catabolic process
M8969_RS07285	COG0628	permease
M8969_RS07300	COG5506	Protein of unknown function (DUF1694)
M8969_RS07305	COG1335	isochorismatase
M8969_RS07310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M8969_RS07315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M8969_RS07340	COG4585	Histidine kinase
M8969_RS07345	COG2197	response regulator
M8969_RS07350	COG2050	protein possibly involved in aromatic compounds catabolism
M8969_RS07355	COG1320	monovalent cation:proton antiporter activity
M8969_RS07360	COG2212	antiporter activity
M8969_RS07365	COG1863	multisubunit Na H antiporter MnhE subunit
M8969_RS07370	COG0651	ATP synthesis coupled electron transport
M8969_RS07375	COG1006	Multisubunit Na H antiporter MnhC subunit
M8969_RS07380	COG2111	Na H antiporter
M8969_RS07385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8969_RS07385	COG2111	Na H antiporter
M8969_RS07395	COG1079	Belongs to the binding-protein-dependent transport system permease family
M8969_RS07400	COG4603	Belongs to the binding-protein-dependent transport system permease family
M8969_RS07405	COG3845	ABC transporter
M8969_RS07410	COG1744	ABC transporter substrate-binding protein PnrA-like
M8969_RS07415	COG4565	transcriptional regulatory protein
M8969_RS07420	COG3290	protein histidine kinase activity
M8969_RS07430	COG3011	Protein conserved in bacteria
M8969_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8969_RS07440	COG2814	Major facilitator Superfamily
M8969_RS07445	COG5018	Exonuclease
M8969_RS07455	COG2205	protein histidine kinase activity
M8969_RS07460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M8969_RS07470	COG2267	carboxylic ester hydrolase activity
M8969_RS07475	COG1522	sequence-specific DNA binding
M8969_RS07480	COG0436	Aminotransferase
M8969_RS07485	COG1098	S1 RNA binding domain
M8969_RS07490	COG2155	Conserved Protein
M8969_RS07495	COG1979	alcohol dehydrogenase
M8969_RS07500	COG1979	alcohol dehydrogenase
M8969_RS07505	COG1335	isochorismatase
M8969_RS07530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M8969_RS07545	COG2738	Putative neutral zinc metallopeptidase
M8969_RS07550	COG1253	flavin adenine dinucleotide binding
M8969_RS07555	COG0366	Alpha amylase catalytic
M8969_RS07560	COG0432	Pfam Uncharacterised protein family UPF0047
M8969_RS07565	COG2070	2-Nitropropane dioxygenase
M8969_RS07580	COG0840	transmembrane signaling receptor activity
M8969_RS07585	COG0840	transmembrane signaling receptor activity
M8969_RS07590	COG0840	transmembrane signaling receptor activity
M8969_RS07595	COG0840	transmembrane signaling receptor activity
M8969_RS07600	COG0693	protein deglycase activity
M8969_RS07605	COG0673	inositol 2-dehydrogenase activity
M8969_RS07610	COG0628	permease
M8969_RS07635	COG1017	nitric oxide dioxygenase activity
M8969_RS07635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8969_RS07640	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8969_RS07645	COG0569	domain protein
M8969_RS07655	COG1510	regulation of RNA biosynthetic process
M8969_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS07665	COG1454	alcohol dehydrogenase
M8969_RS07675	COG2318	DinB family
M8969_RS07680	COG1585	Membrane protein implicated in regulation of membrane protease activity
M8969_RS07685	COG2268	Band 7 protein
M8969_RS07690	COG3859	Proton-coupled thiamine transporter YuaJ
M8969_RS07700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS07700	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8969_RS07710	COG1649	PFAM Uncharacterised BCR, COG1649
M8969_RS07715	COG1960	acyl-CoA dehydrogenase activity
M8969_RS07720	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS07725	COG0439	Biotin carboxylase
M8969_RS07730	COG0511	ligase activity, forming carbon-carbon bonds
M8969_RS07735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M8969_RS07740	COG1024	Enoyl-CoA hydratase
M8969_RS07745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8969_RS07750	COG0586	Pfam SNARE associated Golgi protein
M8969_RS07760	COG2246	polysaccharide biosynthetic process
M8969_RS07770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8969_RS07790	COG2124	cytochrome p450
M8969_RS07795	COG2610	gluconate transmembrane transporter activity
M8969_RS07800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8969_RS07805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8969_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS07835	COG3507	Belongs to the glycosyl hydrolase 43 family
M8969_RS07845	COG0745	RESPONSE REGULATOR receiver
M8969_RS07850	COG2205	protein histidine kinase activity
M8969_RS07900	COG2271	Major facilitator Superfamily
M8969_RS07905	COG1609	Transcriptional regulator
M8969_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS07915	COG1312	Catalyzes the dehydration of D-mannonate
M8969_RS07920	COG0800	Aldolase
M8969_RS07925	COG1063	alcohol dehydrogenase
M8969_RS07935	COG1115	amino acid carrier protein
M8969_RS07945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8969_RS07950	COG0187	DNA topoisomerase II activity
M8969_RS07955	COG1832	CoA-binding protein
M8969_RS07965	COG4841	protein insertion into membrane
M8969_RS07975	COG0824	Thioesterase
M8969_RS07995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS08000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M8969_RS08015	COG0071	Belongs to the small heat shock protein (HSP20) family
M8969_RS08025	COG4846	Membrane protein involved in cytochrome C biogenesis
M8969_RS08030	COG2201	protein-glutamate methylesterase activity
M8969_RS08035	COG0785	Cytochrome C biogenesis protein
M8969_RS08055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M8969_RS08065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M8969_RS08100	COG4195	phage-related replication protein
M8969_RS08110	COG0756	dUTP diphosphatase activity
M8969_RS08115	COG5434	Belongs to the glycosyl hydrolase 28 family
M8969_RS08135	COG3397	chitin binding
M8969_RS08180	COG4451	ribulose bisphosphate carboxylase, small
M8969_RS08180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8969_RS08185	COG1064	alcohol dehydrogenase
M8969_RS08190	COG2318	DinB family
M8969_RS08210	COG3848	Pyruvate phosphate dikinase
M8969_RS08210	COG0574	Belongs to the PEP-utilizing enzyme family
M8969_RS08215	COG1070	Carbohydrate kinase
M8969_RS08230	COG3507	Belongs to the glycosyl hydrolase 43 family
M8969_RS08235	COG2211	Major facilitator Superfamily
M8969_RS08280	COG0174	glutamine synthetase
M8969_RS08285	COG0789	Transcriptional regulator
M8969_RS08290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M8969_RS08295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M8969_RS08300	COG0464	growth
M8969_RS08305	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS08310	COG4112	unkown
M8969_RS08315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8969_RS08320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8969_RS08360	COG2076	Multidrug Resistance protein
M8969_RS08370	COG1764	response to oxidative stress
M8969_RS08375	COG4195	phage-related replication protein
M8969_RS08385	COG1404	Belongs to the peptidase S8 family
M8969_RS08395	COG3619	membrane
M8969_RS08400	COG3209	COG3209 Rhs family protein
M8969_RS08405	COG2124	cytochrome p450
M8969_RS08410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS08410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M8969_RS08410	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8969_RS08410	COG3321	synthase
M8969_RS08415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS08415	COG3321	synthase
M8969_RS08415	COG4221	oxidoreductase activity
M8969_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS08420	COG3321	synthase
M8969_RS08420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS08420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS08420	COG3321	synthase
M8969_RS08420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS08420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS08420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS08420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS08425	COG4221	oxidoreductase activity
M8969_RS08425	COG3321	synthase
M8969_RS08425	COG0300	oxidoreductase activity
M8969_RS08425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS08430	COG3321	synthase
M8969_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS08430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS08430	COG0300	oxidoreductase activity
M8969_RS08435	COG1024	Enoyl-CoA hydratase
M8969_RS08440	COG1024	Enoyl-CoA hydratase
M8969_RS08445	COG3425	synthase
M8969_RS08450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS08495	COG4550	Control of competence regulator ComK, YlbF/YmcA
M8969_RS08515	COG2359	stage V sporulation protein S
M8969_RS08520	COG1692	metallophosphoesterase
M8969_RS08530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8969_RS08545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M8969_RS08550	COG1426	Protein conserved in bacteria
M8969_RS08565	COG0300	oxidoreductase activity
M8969_RS08570	COG0612	Peptidase, M16
M8969_RS08575	COG0612	Peptidase, M16
M8969_RS08580	COG1033	growth of symbiont in host cell
M8969_RS08580	COG2409	Drug exporters of the RND superfamily
M8969_RS08585	COG1846	Transcriptional regulator
M8969_RS08590	COG2814	Major facilitator Superfamily
M8969_RS08595	COG2188	Transcriptional regulator
M8969_RS08600	COG1674	ftsk spoiiie
M8969_RS08600	COG4980	gas vesicle protein
M8969_RS08610	COG0740	serine-type endopeptidase activity
M8969_RS08615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8969_RS08625	COG0527	aspartate kinase activity
M8969_RS08630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M8969_RS08635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8969_RS08640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8969_RS08645	COG1873	PFAM PRC-barrel domain
M8969_RS08650	COG0612	Peptidase, M16
M8969_RS08655	COG0726	polysaccharide deacetylase
M8969_RS08670	COG0196	riboflavin kinase activity
M8969_RS08685	COG1550	Protein conserved in bacteria
M8969_RS08695	COG1358	cellular component organization or biogenesis
M8969_RS08700	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M8969_RS08705	COG0195	Participates in both transcription termination and antitermination
M8969_RS08725	COG0750	zinc metalloprotease
M8969_RS08735	COG4589	Belongs to the CDS family
M8969_RS08740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M8969_RS08770	COG1191	sigma factor activity
M8969_RS08780	COG1776	CheC inhibitor of MCP methylation
M8969_RS08785	COG0835	chemotaxis
M8969_RS08790	COG0643	Histidine kinase
M8969_RS08790	COG2198	Histidine kinase
M8969_RS08795	COG2201	protein-glutamate methylesterase activity
M8969_RS08800	COG0455	bacterial-type flagellum organization
M8969_RS08805	COG1419	protein localization to endoplasmic reticulum
M8969_RS08810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8969_RS08815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8969_RS08820	COG1684	flagellar biosynthetic protein fliR
M8969_RS08825	COG1987	bacterial-type flagellum assembly
M8969_RS08830	COG1338	Plays a role in the flagellum-specific transport system
M8969_RS08835	COG3190	flagellar
M8969_RS08840	COG2201	protein-glutamate methylesterase activity
M8969_RS08845	COG1776	CheC inhibitor of MCP methylation
M8969_RS08845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8969_RS08850	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8969_RS08855	COG1580	Controls the rotational direction of flagella during chemotaxis
M8969_RS08860	COG1582	Flagellar protein (FlbD)
M8969_RS08865	COG4786	Flagellar basal body rod
M8969_RS08870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M8969_RS08875	COG3144	bacterial-type flagellum assembly
M8969_RS08880	COG3334	PFAM MgtE intracellular
M8969_RS08885	COG2882	bacterial-type flagellum organization
M8969_RS08890	COG1157	protein secretion by the type III secretion system
M8969_RS08895	COG1317	bacterial-type flagellum organization
M8969_RS08900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8969_RS08905	COG1766	The M ring may be actively involved in energy transduction
M8969_RS08910	COG1677	Flagellar hook-basal body complex protein FliE
M8969_RS08915	COG1558	bacterial-type flagellum-dependent cell motility
M8969_RS08920	COG1815	bacterial-type flagellum-dependent cell motility
M8969_RS08940	COG4974	Belongs to the 'phage' integrase family
M8969_RS08950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8969_RS08955	COG0758	DNA mediated transformation
M8969_RS08960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M8969_RS08970	COG2257	FlhB HrpN YscU SpaS Family
M8969_RS08985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8969_RS09010	COG1837	Belongs to the UPF0109 family
M8969_RS09020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M8969_RS09035	COG0552	protein localization to endoplasmic reticulum
M8969_RS09040	COG1196	nuclear chromosome segregation
M8969_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS09060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8969_RS09075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M8969_RS09080	COG1760	l-serine dehydratase
M8969_RS09085	COG1760	l-serine dehydratase
M8969_RS09090	COG1461	Dihydroxyacetone kinase
M8969_RS09095	COG1302	Protein conserved in bacteria
M8969_RS09110	COG1564	THIamine pyrophosphokinase
M8969_RS09115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M8969_RS09125	COG0515	serine threonine protein kinase
M8969_RS09125	COG2815	serine threonine protein kinase
M8969_RS09130	COG0631	protein serine/threonine phosphatase activity
M8969_RS09140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M8969_RS09140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8969_RS09150	COG0242	peptide deformylase activity
M8969_RS09155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8969_RS09160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8969_RS09170	COG0194	GDP metabolic process
M8969_RS09180	COG1561	YicC-like family, N-terminal region
M8969_RS09185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M8969_RS09195	COG1648	precorrin-2 dehydrogenase activity
M8969_RS09200	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M8969_RS09205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8969_RS09220	COG0306	phosphate transporter
M8969_RS09230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M8969_RS09235	COG0284	orotidine-5'-phosphate decarboxylase activity
M8969_RS09250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8969_RS09255	COG0505	Belongs to the CarA family
M8969_RS09260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M8969_RS09270	COG2233	PERMEase
M8969_RS09280	COG0564	pseudouridine synthase activity
M8969_RS09290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8969_RS09295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M8969_RS09300	COG3599	regulation of cell shape
M8969_RS09305	COG2302	S4 RNA-binding domain
M8969_RS09310	COG0762	integral membrane protein
M8969_RS09320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M8969_RS09325	COG1496	oxidoreductase activity
M8969_RS09330	COG1873	PFAM PRC-barrel domain
M8969_RS09335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8969_RS09340	COG1119	ATPase activity
M8969_RS09345	COG1191	sigma factor activity
M8969_RS09350	COG1191	sigma factor activity
M8969_RS09360	COG4412	M6 family metalloprotease domain protein
M8969_RS09360	COG1404	Belongs to the peptidase S8 family
M8969_RS09365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M8969_RS09370	COG0849	cell division
M8969_RS09375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M8969_RS09390	COG0772	Belongs to the SEDS family
M8969_RS09410	COG0768	penicillin binding
M8969_RS09415	COG0768	penicillin binding
M8969_RS09420	COG4839	cell division protein FtsL
M8969_RS09440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8969_RS09460	COG1399	metal-binding, possibly nucleic acid-binding protein
M8969_RS09470	COG3480	Lon protease (S16) C-terminal proteolytic domain
M8969_RS09475	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8969_RS09480	COG3314	Sporulation integral membrane protein YlbJ
M8969_RS09490	COG0742	ribosomal rna small subunit methyltransferase
M8969_RS09500	COG3679	Belongs to the UPF0342 family
M8969_RS09515	COG2340	Cysteine-rich secretory protein family
M8969_RS09520	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M8969_RS09530	COG3336	cytochrome c oxidase
M8969_RS09535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M8969_RS09540	COG1845	cytochrome c oxidase, subunit III
M8969_RS09545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8969_RS09550	COG2010	Cytochrome c
M8969_RS09550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8969_RS09565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M8969_RS09570	COG0772	Belongs to the SEDS family
M8969_RS09580	COG2066	Belongs to the glutaminase family
M8969_RS09585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8969_RS09590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M8969_RS09600	COG4896	Protein conserved in bacteria
M8969_RS09610	COG1217	gtp-binding protein TYPA
M8969_RS09630	COG1595	DNA-templated transcription, initiation
M8969_RS09635	COG3227	Zinc metalloprotease (Elastase)
M8969_RS09645	COG0483	inositol monophosphate 1-phosphatase activity
M8969_RS09665	COG1982	Orn Lys Arg decarboxylase major
M8969_RS09680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS09685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8969_RS09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8969_RS09695	COG0022	dehydrogenase e1 component
M8969_RS09700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8969_RS09705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8969_RS09710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS09710	COG4221	oxidoreductase activity
M8969_RS09710	COG3321	synthase
M8969_RS09715	COG3321	synthase
M8969_RS09715	COG4221	oxidoreductase activity
M8969_RS09715	COG0300	oxidoreductase activity
M8969_RS09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS09720	COG0300	oxidoreductase activity
M8969_RS09720	COG4221	oxidoreductase activity
M8969_RS09720	COG3321	synthase
M8969_RS09720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS09725	COG4221	oxidoreductase activity
M8969_RS09725	COG3321	synthase
M8969_RS09725	COG0300	oxidoreductase activity
M8969_RS09725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS09730	COG3321	synthase
M8969_RS09730	COG4221	oxidoreductase activity
M8969_RS09730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS09735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS09735	COG0300	oxidoreductase activity
M8969_RS09735	COG3321	synthase
M8969_RS09735	COG4221	oxidoreductase activity
M8969_RS09740	COG3321	synthase
M8969_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS09740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS09740	COG4221	oxidoreductase activity
M8969_RS09745	COG2070	2-Nitropropane dioxygenase
M8969_RS09745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8969_RS09750	COG0497	DNA recombination
M8969_RS09760	COG0242	peptide deformylase activity
M8969_RS09765	COG0561	phosphatase activity
M8969_RS09775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8969_RS09785	COG0569	domain protein
M8969_RS09790	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M8969_RS09790	COG2105	PFAM AIG2 family protein
M8969_RS09795	COG3852	Histidine kinase
M8969_RS09800	COG2002	toxin-antitoxin pair type II binding
M8969_RS09805	COG1077	Cell shape determining protein MreB Mrl
M8969_RS09815	COG2309	aminopeptidase activity
M8969_RS09820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8969_RS09825	COG0488	(ABC) transporter
M8969_RS09835	COG0681	Belongs to the peptidase S26 family
M8969_RS09840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8969_RS09840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8969_RS09840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS09845	COG1105	Belongs to the carbohydrate kinase PfkB family
M8969_RS09850	COG1349	DNA-binding transcription factor activity
M8969_RS09855	COG0577	efflux transmembrane transporter activity
M8969_RS09860	COG1136	(ABC) transporter
M8969_RS09865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M8969_RS09875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M8969_RS09880	COG0314	molybdopterin synthase activity
M8969_RS09885	COG1763	Mo-molybdopterin cofactor biosynthetic process
M8969_RS09890	COG0303	'Molybdopterin
M8969_RS09895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8969_RS09915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS09920	COG0668	transmembrane transport
M8969_RS09940	COG0716	FMN binding
M8969_RS09950	COG0716	FMN binding
M8969_RS09955	COG0583	DNA-binding transcription factor activity
M8969_RS09960	COG0517	IMP dehydrogenase activity
M8969_RS09970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M8969_RS09975	COG4703	Protein of unknown function (DUF1797)
M8969_RS09980	COG2200	EAL domain
M8969_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS09995	COG1408	metallophosphoesterase
M8969_RS10000	COG1376	ErfK ybiS ycfS ynhG family protein
M8969_RS10005	COG2814	Major facilitator Superfamily
M8969_RS10015	COG0784	Response regulator, receiver
M8969_RS10015	COG0835	chemotaxis
M8969_RS10025	COG0436	Aminotransferase
M8969_RS10030	COG4191	Histidine kinase
M8969_RS10035	COG0768	penicillin binding
M8969_RS10040	COG2340	Cysteine-rich secretory protein family
M8969_RS10045	COG2084	Dehydrogenase
M8969_RS10050	COG0840	transmembrane signaling receptor activity
M8969_RS10055	COG1533	DNA photolyase activity
M8969_RS10065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8969_RS10070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS10075	COG1263	PTS System
M8969_RS10075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8969_RS10075	COG2190	(PTS) system
M8969_RS10080	COG3711	transcriptional antiterminator
M8969_RS10085	COG1609	Transcriptional regulator
M8969_RS10090	COG0006	proline dipeptidase activity
M8969_RS10095	COG2217	Heavy metal translocating P-type atpase
M8969_RS10100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS10105	COG2244	polysaccharide biosynthetic process
M8969_RS10110	COG3773	Cell wall hydrolase
M8969_RS10120	COG4873	Protein conserved in bacteria
M8969_RS10135	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS10140	COG1733	regulation of RNA biosynthetic process
M8969_RS10155	COG0602	queuosine metabolic process
M8969_RS10160	COG0720	synthase
M8969_RS10175	COG3949	Membrane
M8969_RS10180	COG0542	response to heat
M8969_RS10185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8969_RS10190	COG1360	Flagellar Motor Protein
M8969_RS10195	COG1846	Transcriptional regulator
M8969_RS10200	COG3852	Histidine kinase
M8969_RS10230	COG0436	Aminotransferase
M8969_RS10235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8969_RS10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8969_RS10260	COG5002	protein histidine kinase activity
M8969_RS10265	COG3594	Acyltransferase
M8969_RS10275	COG2323	membrane
M8969_RS10280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8969_RS10305	COG1191	sigma factor activity
M8969_RS10315	COG0586	Pfam SNARE associated Golgi protein
M8969_RS10325	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M8969_RS10330	COG1793	dna ligase
M8969_RS10330	COG3285	dna ligase
M8969_RS10335	COG0726	polysaccharide deacetylase
M8969_RS10340	COG1846	Transcriptional regulator
M8969_RS10355	COG0789	Transcriptional regulator
M8969_RS10360	COG2239	Acts as a magnesium transporter
M8969_RS10370	COG1388	LysM domain
M8969_RS10370	COG3858	chitin binding
M8969_RS10375	COG4721	ABC-type cobalt transport system, permease component
M8969_RS10380	COG1122	ATPase activity
M8969_RS10385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8969_RS10390	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS10395	COG1404	Belongs to the peptidase S8 family
M8969_RS10420	COG0457	Tetratricopeptide repeat
M8969_RS10420	COG0463	Glycosyl transferase, family 2
M8969_RS10435	COG1764	response to oxidative stress
M8969_RS10440	COG1846	Transcriptional regulator
M8969_RS10445	COG1764	response to oxidative stress
M8969_RS10455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8969_RS10460	COG0788	formyltetrahydrofolate deformylase activity
M8969_RS10465	COG2076	Multidrug Resistance protein
M8969_RS10470	COG2076	Multidrug Resistance protein
M8969_RS10475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8969_RS10480	COG1607	acyl-coa hydrolase
M8969_RS10485	COG1834	amidinotransferase
M8969_RS10490	COG2706	6-phosphogluconolactonase activity
M8969_RS10495	COG4608	Belongs to the ABC transporter superfamily
M8969_RS10500	COG0791	NLP P60 protein
M8969_RS10505	COG4948	Mandelate Racemase Muconate Lactonizing
M8969_RS10510	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8969_RS10515	COG4166	transmembrane transport
M8969_RS10520	COG0444	Belongs to the ABC transporter superfamily
M8969_RS10525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8969_RS10530	COG0601	transmembrane transport
M8969_RS10535	COG2362	D-Aminopeptidase
M8969_RS10540	COG0477	Major facilitator Superfamily
M8969_RS10545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8969_RS10555	COG0463	Glycosyl transferase, family 2
M8969_RS10560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8969_RS10565	COG0346	lactoylglutathione lyase activity
M8969_RS10570	COG0531	amino acid
M8969_RS10575	COG1392	Phosphate transport regulator
M8969_RS10580	COG0306	phosphate transporter
M8969_RS10600	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS10600	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8969_RS10640	COG3778	Protein conserved in bacteria
M8969_RS10645	COG3299	homolog of phage Mu protein gp47
M8969_RS10650	COG3628	GPW Gp25 family protein
M8969_RS10660	COG4193	domain, Protein
M8969_RS10665	COG1652	LysM domain
M8969_RS10670	COG3953	SLT domain
M8969_RS10670	COG3953	SLT domain
M8969_RS10670	COG5412	phage tail tape measure protein
M8969_RS10670	COG3953	SLT domain
M8969_RS10670	COG5412	phage tail tape measure protein
M8969_RS10670	COG5412	phage tail tape measure protein
M8969_RS10720	COG4653	Phage capsid family
M8969_RS10725	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M8969_RS10730	COG5518	Phage portal protein
M8969_RS10735	COG1783	phage Terminase large subunit
M8969_RS10740	COG3728	DNA packaging
M8969_RS10740	COG5484	DNA packaging
M8969_RS10745	COG1595	DNA-templated transcription, initiation
M8969_RS10765	COG1484	DNA-dependent DNA replication
M8969_RS10770	COG1522	sequence-specific DNA binding
M8969_RS10780	COG1396	sequence-specific DNA binding
M8969_RS10785	COG2856	Zn peptidase
M8969_RS10790	COG4195	phage-related replication protein
M8969_RS10800	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS10800	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8969_RS10800	COG1388	LysM domain
M8969_RS10810	COG0457	Tetratricopeptide repeat
M8969_RS10815	COG2318	DinB family
M8969_RS10820	COG0730	response to heat
M8969_RS10855	COG2197	response regulator
M8969_RS10860	COG4585	Histidine kinase
M8969_RS10880	COG2205	protein histidine kinase activity
M8969_RS10880	COG2770	Histidine kinase
M8969_RS10885	COG0745	RESPONSE REGULATOR receiver
M8969_RS10890	COG2721	sulfolactate sulfo-lyase activity
M8969_RS10895	COG0246	Mannitol dehydrogenase
M8969_RS10900	COG1609	Transcriptional regulator
M8969_RS10905	COG2211	Major facilitator Superfamily
M8969_RS10915	COG1252	NADH dehydrogenase
M8969_RS10925	COG4297	protein containing double-stranded beta helix domain
M8969_RS10930	COG0697	spore germination
M8969_RS10935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8969_RS10940	COG0390	transport system, permease component
M8969_RS10945	COG1587	Uroporphyrinogen-III synthase
M8969_RS10955	COG1819	glycosyl
M8969_RS10960	COG2124	cytochrome p450
M8969_RS10965	COG2427	Protein of unknown function (DUF1641)
M8969_RS10970	COG3383	formate dehydrogenase (NAD+) activity
M8969_RS10980	COG2205	protein histidine kinase activity
M8969_RS10995	COG1285	pathogenesis
M8969_RS11015	COG1349	DNA-binding transcription factor activity
M8969_RS11025	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8969_RS11030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS11030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8969_RS11035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8969_RS11040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8969_RS11045	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8969_RS11055	COG1846	Transcriptional regulator
M8969_RS11060	COG0477	Major facilitator Superfamily
M8969_RS11065	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8969_RS11070	COG2367	Beta-lactamase
M8969_RS11075	COG0346	lactoylglutathione lyase activity
M8969_RS11085	COG5444	nuclease activity
M8969_RS11115	COG0626	cystathionine gamma-synthase activity
M8969_RS11120	COG0626	cystathionine gamma-synthase activity
M8969_RS11125	COG2382	esterase
M8969_RS11135	COG2153	protein acetylation
M8969_RS11145	COG1131	(ABC) transporter
M8969_RS11165	COG0210	DNA helicase
M8969_RS11220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M8969_RS11225	COG0351	phosphomethylpyrimidine kinase
M8969_RS11230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8969_RS11240	COG2104	thiamine diphosphate biosynthetic process
M8969_RS11245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8969_RS11250	COG0352	thiamine-phosphate diphosphorylase activity
M8969_RS11255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M8969_RS11260	COG0475	glutathione-regulated potassium exporter activity
M8969_RS11260	COG0569	domain protein
M8969_RS11270	COG0564	pseudouridine synthase activity
M8969_RS11275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8969_RS11280	COG2357	RelA SpoT domain protein
M8969_RS11290	COG4116	CYTH
M8969_RS11295	COG0741	lytic transglycosylase activity
M8969_RS11300	COG2346	COG2346, Truncated hemoglobins
M8969_RS11305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8969_RS11315	COG1164	Oligoendopeptidase f
M8969_RS11320	COG4469	Competence protein
M8969_RS11325	COG4862	establishment of competence for transformation
M8969_RS11335	COG0861	Integral membrane protein TerC family
M8969_RS11340	COG1393	Belongs to the ArsC family
M8969_RS11345	COG0456	acetyltransferase
M8969_RS11355	COG4608	Belongs to the ABC transporter superfamily
M8969_RS11360	COG0444	Belongs to the ABC transporter superfamily
M8969_RS11365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8969_RS11370	COG0601	transmembrane transport
M8969_RS11375	COG4166	transmembrane transport
M8969_RS11380	COG0180	Tryptophanyl-tRNA synthetase
M8969_RS11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8969_RS11395	COG0601	transmembrane transport
M8969_RS11405	COG4608	Belongs to the ABC transporter superfamily
M8969_RS11410	COG0444	Belongs to the ABC transporter superfamily
M8969_RS11415	COG5504	Zn-dependent protease
M8969_RS11420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8969_RS11425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8969_RS11440	COG1744	ABC transporter substrate-binding protein PnrA-like
M8969_RS11450	COG2267	carboxylic ester hydrolase activity
M8969_RS11465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8969_RS11470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8969_RS11475	COG0505	Belongs to the CarA family
M8969_RS11480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8969_RS11490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M8969_RS11500	COG2271	Major facilitator Superfamily
M8969_RS11505	COG0277	FAD linked oxidase domain protein
M8969_RS11515	COG2151	metal-sulfur cluster biosynthetic enzyme
M8969_RS11520	COG1073	alpha beta
M8969_RS11525	COG0561	phosphatase activity
M8969_RS11545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS11550	COG1307	EDD domain protein, DegV family
M8969_RS11560	COG2124	cytochrome p450
M8969_RS11565	COG0840	transmembrane signaling receptor activity
M8969_RS11570	COG1744	ABC transporter substrate-binding protein PnrA-like
M8969_RS11575	COG2996	Protein conserved in bacteria
M8969_RS11585	COG0646	methionine synthase
M8969_RS11585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M8969_RS11590	COG2153	protein acetylation
M8969_RS11595	COG1357	PFAM Pentapeptide repeats (8 copies)
M8969_RS11600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS11605	COG1279	arginine transmembrane transporter activity
M8969_RS11610	COG2318	DinB family
M8969_RS11620	COG1917	Cupin 2, conserved barrel domain protein
M8969_RS11620	COG2207	Transcriptional regulator
M8969_RS11625	COG0534	Mate efflux family protein
M8969_RS11630	COG1562	ergosterol biosynthetic process
M8969_RS11635	COG0367	asparagine synthase
M8969_RS11650	COG0179	Fumarylacetoacetate (FAA) hydrolase
M8969_RS11690	COG1403	HNH endonuclease
M8969_RS11695	COG0419	ATPase involved in DNA repair
M8969_RS11700	COG0420	3'-5' exonuclease activity
M8969_RS11715	COG2323	membrane
M8969_RS11720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M8969_RS11730	COG2814	Major facilitator Superfamily
M8969_RS11735	COG3180	Ammonia monooxygenase
M8969_RS11740	COG1846	Transcriptional regulator
M8969_RS11745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8969_RS11750	COG0681	Belongs to the peptidase S26 family
M8969_RS11755	COG0398	Pfam SNARE associated Golgi protein
M8969_RS11770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8969_RS11790	COG5646	InterPro IPR014922
M8969_RS11800	COG4903	ComK protein
M8969_RS11810	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS11815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8969_RS11815	COG0723	plastoquinol--plastocyanin reductase activity
M8969_RS11820	COG0840	transmembrane signaling receptor activity
M8969_RS11825	COG1268	BioY protein
M8969_RS11830	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS11835	COG0183	Belongs to the thiolase family
M8969_RS11840	COG0406	alpha-ribazole phosphatase activity
M8969_RS11845	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M8969_RS11850	COG1404	Belongs to the peptidase S8 family
M8969_RS11855	COG0501	Belongs to the peptidase M48B family
M8969_RS11865	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS11870	COG0702	epimerase
M8969_RS11875	COG0095	Lipoate-protein ligase
M8969_RS11880	COG1234	tRNA 3'-trailer cleavage
M8969_RS11890	COG1301	dicarboxylic acid transport
M8969_RS11895	COG1363	Peptidase, m42
M8969_RS11905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8969_RS11910	COG1511	domain protein
M8969_RS11915	COG1309	transcriptional regulator
M8969_RS11920	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M8969_RS11925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M8969_RS11935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8969_RS11940	COG2329	Antibiotic biosynthesis monooxygenase
M8969_RS11945	COG3069	C4-dicarboxylate transmembrane transporter activity
M8969_RS11950	COG1473	amidohydrolase
M8969_RS11960	COG4473	ABC transporter
M8969_RS11965	COG1131	(ABC) transporter
M8969_RS11970	COG0537	adenosine 5'-monophosphoramidase activity
M8969_RS11975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M8969_RS11990	COG4980	gas vesicle protein
M8969_RS12025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8969_RS12040	COG4717	serine-type aminopeptidase activity
M8969_RS12045	COG0420	3'-5' exonuclease activity
M8969_RS12050	COG1668	transmembrane transport
M8969_RS12055	COG4152	abc transporter atp-binding protein
M8969_RS12065	COG1024	Enoyl-CoA hydratase
M8969_RS12075	COG0490	domain, Protein
M8969_RS12080	COG0475	glutathione-regulated potassium exporter activity
M8969_RS12090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8969_RS12095	COG0561	phosphatase activity
M8969_RS12100	COG4335	DNA alkylation repair
M8969_RS12115	COG0189	ligase activity
M8969_RS12120	COG0189	ligase activity
M8969_RS12140	COG0702	epimerase
M8969_RS12145	COG1132	(ABC) transporter
M8969_RS12150	COG1132	(ABC) transporter
M8969_RS12155	COG0589	response to stress
M8969_RS12165	COG3226	Transcriptional regulator
M8969_RS12170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8969_RS12175	COG0726	polysaccharide deacetylase
M8969_RS12180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M8969_RS12185	COG0668	transmembrane transport
M8969_RS12195	COG0584	glycerophosphoryl diester phosphodiesterase
M8969_RS12200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8969_RS12205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8969_RS12210	COG1253	flavin adenine dinucleotide binding
M8969_RS12215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8969_RS12220	COG0436	Aminotransferase
M8969_RS12225	COG0789	Transcriptional regulator
M8969_RS12230	COG1253	flavin adenine dinucleotide binding
M8969_RS12235	COG0204	Acyl-transferase
M8969_RS12240	COG1595	DNA-templated transcription, initiation
M8969_RS12255	COG0733	neurotransmitter:sodium symporter activity
M8969_RS12260	COG0531	amino acid
M8969_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS12270	COG0372	Belongs to the citrate synthase family
M8969_RS12275	COG0583	DNA-binding transcription factor activity
M8969_RS12280	COG1388	LysM domain
M8969_RS12280	COG0791	NLP P60 protein
M8969_RS12285	COG1785	Belongs to the alkaline phosphatase family
M8969_RS12290	COG2719	SpoVR family
M8969_RS12300	COG1959	2 iron, 2 sulfur cluster binding
M8969_RS12305	COG1388	LysM domain
M8969_RS12305	COG0791	NLP P60 protein
M8969_RS12320	COG0431	NADPH-dependent FMN reductase
M8969_RS12325	COG2197	response regulator
M8969_RS12330	COG2203	Gaf domain
M8969_RS12330	COG4585	Histidine kinase
M8969_RS12335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8969_RS12340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M8969_RS12350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M8969_RS12355	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M8969_RS12360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8969_RS12365	COG3153	acetyltransferase
M8969_RS12365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8969_RS12370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8969_RS12375	COG0517	IMP dehydrogenase activity
M8969_RS12385	COG0564	pseudouridine synthase activity
M8969_RS12390	COG3764	Sortase (surface protein transpeptidase)
M8969_RS12395	COG0737	Belongs to the 5'-nucleotidase family
M8969_RS12395	COG1525	nuclease
M8969_RS12395	COG4085	toxin activity
M8969_RS12400	COG5577	PFAM Coat F domain
M8969_RS12420	COG1823	symporter activity
M8969_RS12425	COG3706	GGDEF domain
M8969_RS12430	COG1464	Belongs to the NlpA lipoprotein family
M8969_RS12435	COG1278	Cold shock
M8969_RS12440	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8969_RS12455	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8969_RS12460	COG2814	Major facilitator Superfamily
M8969_RS12465	COG1566	PFAM secretion protein HlyD family protein
M8969_RS12470	COG1846	Transcriptional regulator
M8969_RS12480	COG2766	serine protein kinase
M8969_RS12485	COG1664	Polymer-forming cytoskeletal
M8969_RS12490	COG1664	Polymer-forming cytoskeletal
M8969_RS12495	COG0789	Transcriptional regulator
M8969_RS12500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M8969_RS12510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8969_RS12515	COG3382	B3 4 domain protein
M8969_RS12525	COG1476	TRANSCRIPTIONal
M8969_RS12545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8969_RS12550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8969_RS12555	COG1116	anion transmembrane transporter activity
M8969_RS12565	COG0753	catalase activity
M8969_RS12570	COG4608	Belongs to the ABC transporter superfamily
M8969_RS12575	COG0444	Belongs to the ABC transporter superfamily
M8969_RS12580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8969_RS12585	COG0601	transmembrane transport
M8969_RS12590	COG0747	negative chemotaxis
M8969_RS12600	COG0277	FAD linked oxidase domain protein
M8969_RS12610	COG3340	Belongs to the peptidase S51 family
M8969_RS12810	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M8969_RS12815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8969_RS12820	COG1169	isochorismate synthase
M8969_RS12830	COG0596	Alpha beta hydrolase
M8969_RS12835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M8969_RS12845	COG4948	Mandelate Racemase Muconate Lactonizing
M8969_RS12860	COG1294	oxidase, subunit
M8969_RS12865	COG1271	oxidase subunit
M8969_RS12875	COG0288	reversible hydration of carbon dioxide
M8969_RS12900	COG0783	Belongs to the Dps family
M8969_RS12905	COG4824	toxin secretion phage lysis holin
M8969_RS12910	COG0494	nUDIX hydrolase
M8969_RS12915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8969_RS12920	COG1116	anion transmembrane transporter activity
M8969_RS12925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8969_RS12930	COG1506	peptidase
M8969_RS12950	COG0367	asparagine synthase
M8969_RS12955	COG1113	amino acid transport
M8969_RS12960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8969_RS12965	COG2267	carboxylic ester hydrolase activity
M8969_RS12975	COG0584	glycerophosphoryl diester phosphodiesterase
M8969_RS12985	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M8969_RS12990	COG1242	4 iron, 4 sulfur cluster binding
M8969_RS13005	COG1725	Transcriptional regulator
M8969_RS13010	COG1131	(ABC) transporter
M8969_RS13030	COG1136	(ABC) transporter
M8969_RS13035	COG0577	efflux transmembrane transporter activity
M8969_RS13040	COG0745	RESPONSE REGULATOR receiver
M8969_RS13045	COG2205	protein histidine kinase activity
M8969_RS13050	COG1136	(ABC) transporter
M8969_RS13055	COG0577	efflux transmembrane transporter activity
M8969_RS13060	COG5522	Integral membrane protein (intg_mem_TP0381)
M8969_RS13065	COG2814	Major facilitator Superfamily
M8969_RS13070	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS13070	COG2202	Pas domain
M8969_RS13085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8969_RS13095	COG1486	melibiose metabolic process
M8969_RS13100	COG0395	ABC-type sugar transport system, permease component
M8969_RS13105	COG1175	transmembrane transport
M8969_RS13110	COG1653	transport
M8969_RS13115	COG1609	Transcriptional regulator
M8969_RS13125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M8969_RS13130	COG2081	HI0933 family
M8969_RS13135	COG2244	polysaccharide biosynthetic process
M8969_RS13140	COG1187	pseudouridine synthase activity
M8969_RS13145	COG1349	DNA-binding transcription factor activity
M8969_RS13150	COG1131	(ABC) transporter
M8969_RS13155	COG4473	ABC transporter
M8969_RS13160	COG2252	PERMEase
M8969_RS13165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8969_RS13170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8969_RS13175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M8969_RS13185	COG1597	lipid kinase activity
M8969_RS13190	COG0510	thiamine kinase activity
M8969_RS13205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS13210	COG0281	malic enzyme
M8969_RS13215	COG5584	Small secreted protein
M8969_RS13220	COG1363	Peptidase, m42
M8969_RS13230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS13240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8969_RS13245	COG1674	ftsk spoiiie
M8969_RS13255	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8969_RS13260	COG4980	gas vesicle protein
M8969_RS13265	COG3118	belongs to the thioredoxin family
M8969_RS13270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M8969_RS13270	COG1605	Chorismate mutase
M8969_RS13275	COG1609	Transcriptional regulator
M8969_RS13280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8969_RS13285	COG1360	Flagellar Motor Protein
M8969_RS13290	COG0123	including yeast histone deacetylase and acetoin utilization protein
M8969_RS13295	COG0517	IMP dehydrogenase activity
M8969_RS13300	COG0454	-acetyltransferase
M8969_RS13305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8969_RS13325	COG1378	Sugar-specific transcriptional regulator TrmB
M8969_RS13330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8969_RS13345	COG0693	protein deglycase activity
M8969_RS13355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8969_RS13355	COG1017	nitric oxide dioxygenase activity
M8969_RS13400	COG4282	regulation of fungal-type cell wall biogenesis
M8969_RS13405	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS13415	COG2199	diguanylate cyclase activity
M8969_RS13415	COG2203	Gaf domain
M8969_RS13420	COG1956	GAF domain-containing protein
M8969_RS13425	COG1309	transcriptional regulator
M8969_RS13430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8969_RS13440	COG1114	Component of the transport system for branched-chain amino acids
M8969_RS13445	COG1104	cysteine desulfurase activity
M8969_RS13460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8969_RS13465	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M8969_RS13470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8969_RS13475	COG0616	signal peptide processing
M8969_RS13480	COG1714	RDD family
M8969_RS13490	COG3874	Sporulation protein YtfJ
M8969_RS13495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M8969_RS13500	COG0827	DNA restriction-modification system
M8969_RS13510	COG0521	Mo-molybdopterin cofactor biosynthetic process
M8969_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS13535	COG4109	DRTGG domain
M8969_RS13545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M8969_RS13565	COG0587	DNA-directed DNA polymerase activity
M8969_RS13570	COG0281	malic enzyme
M8969_RS13590	COG0469	pyruvate kinase activity
M8969_RS13595	COG3030	protein affecting phage T7 exclusion by the F plasmid
M8969_RS13600	COG0628	permease
M8969_RS13630	COG0372	Belongs to the citrate synthase family
M8969_RS13635	COG0538	isocitrate dehydrogenase activity
M8969_RS13645	COG0745	RESPONSE REGULATOR receiver
M8969_RS13650	COG5002	protein histidine kinase activity
M8969_RS13655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8969_RS13655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8969_RS13660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M8969_RS13665	COG1971	Probably functions as a manganese efflux pump
M8969_RS13670	COG0237	dephospho-CoA kinase activity
M8969_RS13675	COG0656	L-ascorbic acid biosynthetic process
M8969_RS13680	COG2814	Major facilitator Superfamily
M8969_RS13685	COG1733	regulation of RNA biosynthetic process
M8969_RS13690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8969_RS13705	COG3611	Membrane attachment protein
M8969_RS13710	COG1484	DNA-dependent DNA replication
M8969_RS13715	COG0398	Pfam SNARE associated Golgi protein
M8969_RS13730	COG1011	Hydrolase
M8969_RS13735	COG3275	phosphorelay sensor kinase activity
M8969_RS13740	COG3279	Response regulator of the LytR AlgR family
M8969_RS13745	COG1380	Effector of murein hydrolase LrgA
M8969_RS13750	COG1346	cytolysis
M8969_RS13755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M8969_RS13770	COG3326	Membrane
M8969_RS13780	COG1363	Peptidase, m42
M8969_RS13785	COG3507	Belongs to the glycosyl hydrolase 43 family
M8969_RS13790	COG2160	L-arabinose isomerase activity
M8969_RS13795	COG1069	ribulokinase activity
M8969_RS13800	COG0235	Class ii aldolase
M8969_RS13805	COG0647	UMP catabolic process
M8969_RS13815	COG1653	transport
M8969_RS13820	COG1175	transmembrane transport
M8969_RS13825	COG0395	ABC-type sugar transport system, permease component
M8969_RS13830	COG3534	alpha-L-arabinofuranosidase
M8969_RS13835	COG1966	Carbon starvation protein
M8969_RS13840	COG0247	lactate metabolic process
M8969_RS13845	COG0277	FAD linked oxidase domain protein
M8969_RS13850	COG3835	regulator
M8969_RS13860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8969_RS13865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M8969_RS13870	COG0072	phenylalanine-tRNA ligase activity
M8969_RS13870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8969_RS13885	COG1286	toxin biosynthetic process
M8969_RS13890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8969_RS13890	COG1796	DNA polymerase
M8969_RS13900	COG3766	membrane
M8969_RS13910	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS13915	COG1309	transcriptional regulator
M8969_RS13920	COG1024	Enoyl-CoA hydratase
M8969_RS13925	COG2086	electron transfer activity
M8969_RS13930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M8969_RS13935	COG3534	alpha-L-arabinofuranosidase
M8969_RS13940	COG3118	belongs to the thioredoxin family
M8969_RS13950	COG0527	aspartate kinase activity
M8969_RS13955	COG1719	4-vinyl reductase, 4VR
M8969_RS13960	COG2009	succinate dehydrogenase
M8969_RS13965	COG1053	succinate dehydrogenase
M8969_RS13970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M8969_RS13975	COG0824	Thioesterase
M8969_RS13980	COG2197	response regulator
M8969_RS13985	COG1846	Transcriptional regulator
M8969_RS13995	COG5401	PFAM Sporulation and spore germination
M8969_RS14005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M8969_RS14010	COG0622	Phosphoesterase
M8969_RS14035	COG0028	Belongs to the TPP enzyme family
M8969_RS14040	COG0440	acetolactate synthase activity
M8969_RS14055	COG0473	3-isopropylmalate dehydrogenase activity
M8969_RS14070	COG0457	Tetratricopeptide repeat
M8969_RS14070	COG1477	protein flavinylation
M8969_RS14085	COG0470	DNA polymerase III
M8969_RS14085	COG1067	ATP-dependent peptidase activity
M8969_RS14090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M8969_RS14110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8969_RS14120	COG1587	Uroporphyrinogen-III synthase
M8969_RS14125	COG0113	porphobilinogen synthase activity
M8969_RS14135	COG1388	LysM domain
M8969_RS14140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8969_RS14150	COG0525	valine-tRNA ligase activity
M8969_RS14155	COG0285	dihydrofolate synthase activity
M8969_RS14160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M8969_RS14180	COG1077	Cell shape determining protein MreB Mrl
M8969_RS14190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M8969_RS14195	COG0850	regulation of cytokinetic process
M8969_RS14200	COG2894	cell division
M8969_RS14205	COG0739	heme binding
M8969_RS14210	COG1994	Peptidase M50
M8969_RS14220	COG2868	ribosomal protein
M8969_RS14225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M8969_RS14230	COG3290	protein histidine kinase activity
M8969_RS14245	COG0077	Prephenate dehydratase
M8969_RS14250	COG1827	regulation of RNA biosynthetic process
M8969_RS14255	COG1104	cysteine desulfurase activity
M8969_RS14260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M8969_RS14265	COG0157	Belongs to the NadC ModD family
M8969_RS14275	COG1388	LysM domain
M8969_RS14315	COG1862	Preprotein translocase
M8969_RS14325	COG2323	membrane
M8969_RS14330	COG2244	polysaccharide biosynthetic process
M8969_RS14340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8969_RS14340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8969_RS14345	COG0490	domain, Protein
M8969_RS14350	COG5416	Lipopolysaccharide assembly protein A domain
M8969_RS14355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M8969_RS14355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M8969_RS14365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M8969_RS14375	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS14375	COG3103	Sh3 type 3 domain protein
M8969_RS14375	COG4991	sh3 domain protein
M8969_RS14400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M8969_RS14405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8969_RS14410	COG1959	2 iron, 2 sulfur cluster binding
M8969_RS14415	COG1104	cysteine desulfurase activity
M8969_RS14425	COG0457	Tetratricopeptide repeat
M8969_RS14430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M8969_RS14435	COG3881	PFAM PRC-barrel domain
M8969_RS14450	COG0765	amino acid transport
M8969_RS14455	COG0765	amino acid transport
M8969_RS14460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8969_RS14465	COG1126	abc transporter atp-binding protein
M8969_RS14470	COG0628	permease
M8969_RS14495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8969_RS14500	COG4122	O-methyltransferase activity
M8969_RS14505	COG0826	peptidase U32
M8969_RS14510	COG0826	peptidase U32
M8969_RS14525	COG0768	penicillin binding
M8969_RS14550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8969_RS14555	COG0626	cystathionine gamma-synthase activity
M8969_RS14565	COG2427	Protein of unknown function (DUF1641)
M8969_RS14570	COG3383	formate dehydrogenase (NAD+) activity
M8969_RS14575	COG5609	conserved protein (DUF2294)
M8969_RS14580	COG2116	formate transmembrane transporter activity
M8969_RS14595	COG2226	methyltransferase
M8969_RS14600	COG1309	transcriptional regulator
M8969_RS14605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8969_RS14605	COG2124	cytochrome p450
M8969_RS14610	COG2814	Major facilitator Superfamily
M8969_RS14615	COG0583	DNA-binding transcription factor activity
M8969_RS14620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M8969_RS14630	COG3711	transcriptional antiterminator
M8969_RS14630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS14635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8969_RS14635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8969_RS14635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8969_RS14640	COG1482	cell wall glycoprotein biosynthetic process
M8969_RS14650	COG0561	phosphatase activity
M8969_RS14655	COG0561	phosphatase activity
M8969_RS14665	COG2318	DinB family
M8969_RS14670	COG0456	acetyltransferase
M8969_RS14675	COG2814	Major facilitator Superfamily
M8969_RS14685	COG0563	adenylate kinase activity
M8969_RS14690	COG0454	-acetyltransferase
M8969_RS14700	COG2311	Membrane
M8969_RS14705	COG0745	RESPONSE REGULATOR receiver
M8969_RS14710	COG0642	Histidine kinase
M8969_RS14710	COG5002	protein histidine kinase activity
M8969_RS14750	COG3677	Transposase
M8969_RS14780	COG0656	L-ascorbic acid biosynthetic process
M8969_RS14800	COG1794	racemase activity, acting on amino acids and derivatives
M8969_RS14825	COG0398	Pfam SNARE associated Golgi protein
M8969_RS14835	COG2755	lipolytic protein G-D-S-L family
M8969_RS14845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M8969_RS14850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8969_RS14855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M8969_RS14860	COG1534	Rna-binding protein
M8969_RS14870	COG1713	HD superfamily hydrolase involved in NAD metabolism
M8969_RS14875	COG0799	negative regulation of ribosome biogenesis
M8969_RS14880	COG2226	methyltransferase
M8969_RS14885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8969_RS14890	COG1555	photosystem II stabilization
M8969_RS14890	COG1596	polysaccharide export
M8969_RS14895	COG2131	deaminase
M8969_RS14900	COG0658	competence protein
M8969_RS14900	COG2333	competence protein COMEC
M8969_RS14930	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS14945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8969_RS14975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M8969_RS14980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8969_RS14985	COG1283	sodium-dependent phosphate transmembrane transporter activity
M8969_RS14995	COG1610	YqeY-like protein
M8969_RS15000	COG1030	water channel activity
M8969_RS15005	COG4864	UPF0365 protein
M8969_RS15020	COG0561	phosphatase activity
M8969_RS15025	COG1702	phosphate starvation-inducible protein PhoH
M8969_RS15030	COG1480	7TM receptor with intracellular HD hydrolase
M8969_RS15040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M8969_RS15045	COG0295	cytidine deaminase activity
M8969_RS15050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M8969_RS15070	COG0751	glycine-tRNA ligase activity
M8969_RS15075	COG0517	IMP dehydrogenase activity
M8969_RS15090	COG0358	DNA primase activity
M8969_RS15095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M8969_RS15100	COG2010	Cytochrome c
M8969_RS15105	COG2384	SAM-dependent methyltransferase
M8969_RS15110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M8969_RS15125	COG0513	Belongs to the DEAD box helicase family
M8969_RS15140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS15145	COG0735	belongs to the Fur family
M8969_RS15150	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M8969_RS15155	COG4709	membrane
M8969_RS15165	COG1388	LysM domain
M8969_RS15170	COG5521	maltodextrose utilization protein MalA
M8969_RS15175	COG2839	Protein conserved in bacteria
M8969_RS15180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8969_RS15185	COG0477	Major facilitator Superfamily
M8969_RS15190	COG0768	penicillin binding
M8969_RS15195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M8969_RS15200	COG0573	inorganic phosphate transmembrane transporter activity
M8969_RS15205	COG0581	inorganic phosphate transmembrane transporter activity
M8969_RS15210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8969_RS15215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8969_RS15220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8969_RS15235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M8969_RS15245	COG1757	Na H antiporter
M8969_RS15250	COG4483	Protein conserved in bacteria
M8969_RS15255	COG1940	carbohydrate kinase activity
M8969_RS15260	COG2866	Carboxypeptidase
M8969_RS15270	COG0011	TIGRFAM Protein of
M8969_RS15280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS15290	COG1393	Belongs to the ArsC family
M8969_RS15300	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS15305	COG1253	flavin adenine dinucleotide binding
M8969_RS15310	COG0598	Magnesium transport protein CorA
M8969_RS15315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M8969_RS15320	COG1459	type II secretion system
M8969_RS15325	COG4537	Required for transformation and DNA binding
M8969_RS15330	COG4970	Tfp pilus assembly protein FimT
M8969_RS15340	COG4940	Competence protein ComGF
M8969_RS15365	COG0681	Belongs to the peptidase S26 family
M8969_RS15375	COG1396	sequence-specific DNA binding
M8969_RS15390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8969_RS15410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8969_RS15425	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8969_RS15435	COG3872	metal-dependent enzyme
M8969_RS15445	COG0006	proline dipeptidase activity
M8969_RS15460	COG3854	ATPases associated with a variety of cellular activities
M8969_RS15500	COG0511	ligase activity, forming carbon-carbon bonds
M8969_RS15505	COG0439	Biotin carboxylase
M8969_RS15510	COG1302	Protein conserved in bacteria
M8969_RS15525	COG1570	exodeoxyribonuclease VII activity
M8969_RS15535	COG0142	geranyltranstransferase activity
M8969_RS15545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M8969_RS15555	COG0497	DNA recombination
M8969_RS15560	COG0750	zinc metalloprotease
M8969_RS15565	COG0745	RESPONSE REGULATOR receiver
M8969_RS15570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8969_RS15585	COG1902	pentaerythritol trinitrate reductase activity
M8969_RS15610	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS15615	COG0584	glycerophosphoryl diester phosphodiesterase
M8969_RS15620	COG0183	Belongs to the thiolase family
M8969_RS15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8969_RS15630	COG1960	acyl-CoA dehydrogenase activity
M8969_RS15635	COG0372	Belongs to the citrate synthase family
M8969_RS15640	COG2079	MmgE PrpD family protein
M8969_RS15645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M8969_RS15655	COG3290	protein histidine kinase activity
M8969_RS15655	COG3829	transcription factor binding
M8969_RS15660	COG0280	phosphate acetyltransferase
M8969_RS15665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8969_RS15670	COG3426	butyrate kinase activity
M8969_RS15675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8969_RS15680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8969_RS15685	COG0022	dehydrogenase e1 component
M8969_RS15690	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8969_RS15695	COG1597	lipid kinase activity
M8969_RS15705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8969_RS15710	COG0765	amino acid transport
M8969_RS15715	COG1126	abc transporter atp-binding protein
M8969_RS15720	COG4129	membrane
M8969_RS15735	COG0346	lactoylglutathione lyase activity
M8969_RS15740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8969_RS15745	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8969_RS15750	COG0706	membrane insertase activity
M8969_RS15765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M8969_RS15770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M8969_RS15785	COG0596	Alpha beta hydrolase
M8969_RS15805	COG0250	Participates in transcription elongation, termination and antitermination
M8969_RS15810	COG2070	2-Nitropropane dioxygenase
M8969_RS15810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8969_RS15825	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS15835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15835	COG3321	synthase
M8969_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15840	COG0300	oxidoreductase activity
M8969_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS15840	COG3321	synthase
M8969_RS15840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15845	COG3321	synthase
M8969_RS15845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS15845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15850	COG3321	synthase
M8969_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15850	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS15850	COG0300	oxidoreductase activity
M8969_RS15855	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15855	COG3321	synthase
M8969_RS15855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15855	COG0318	PFAM AMP-dependent synthetase and ligase
M8969_RS15855	COG0300	oxidoreductase activity
M8969_RS15860	COG3321	synthase
M8969_RS15860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS15860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15865	COG3321	synthase
M8969_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS15865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8969_RS15865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8969_RS15870	COG2124	cytochrome p450
M8969_RS15875	COG3425	synthase
M8969_RS15880	COG1024	Enoyl-CoA hydratase
M8969_RS15885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8969_RS15890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS15895	COG0300	oxidoreductase activity
M8969_RS15900	COG3048	D-serine ammonia-lyase activity
M8969_RS15910	COG0346	lactoylglutathione lyase activity
M8969_RS15920	COG0628	permease
M8969_RS15935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8969_RS15940	COG0456	acetyltransferase
M8969_RS15945	COG2329	Antibiotic biosynthesis monooxygenase
M8969_RS15950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M8969_RS15950	COG0456	acetyltransferase
M8969_RS15955	COG4918	Iron-sulphur cluster biosynthesis
M8969_RS15965	COG1073	alpha beta
M8969_RS15975	COG0667	Aldo Keto reductase
M8969_RS15985	COG0494	nUDIX hydrolase
M8969_RS15990	COG1379	DNA repair
M8969_RS15995	COG1396	sequence-specific DNA binding
M8969_RS16000	COG0252	asparaginase activity
M8969_RS16005	COG1027	Aspartate ammonia-lyase
M8969_RS16010	COG1757	Na H antiporter
M8969_RS16015	COG0281	malic enzyme
M8969_RS16030	COG1300	Membrane
M8969_RS16035	COG0735	belongs to the Fur family
M8969_RS16045	COG4974	Belongs to the 'phage' integrase family
M8969_RS16050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M8969_RS16055	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M8969_RS16060	COG1686	Belongs to the peptidase S11 family
M8969_RS16065	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS16075	COG1191	sigma factor activity
M8969_RS16095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8969_RS16110	COG0697	spore germination
M8969_RS16115	COG0019	diaminopimelate decarboxylase activity
M8969_RS16120	COG4086	secreted protein
M8969_RS16125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M8969_RS16135	COG0681	Belongs to the peptidase S26 family
M8969_RS16145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8969_RS16145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8969_RS16150	COG0307	riboflavin synthase, alpha
M8969_RS16165	COG0456	acetyltransferase
M8969_RS16170	COG1547	Domain of unknown function (DUF309)
M8969_RS16195	COG1686	Belongs to the peptidase S11 family
M8969_RS16200	COG2715	membrane protein required for spore maturation
M8969_RS16205	COG0700	Nucleoside recognition
M8969_RS16210	COG1187	pseudouridine synthase activity
M8969_RS16215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8969_RS16220	COG1333	cytochrome c biogenesis protein
M8969_RS16225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8969_RS16230	COG0745	RESPONSE REGULATOR receiver
M8969_RS16235	COG5002	protein histidine kinase activity
M8969_RS16240	COG1595	DNA-templated transcription, initiation
M8969_RS16250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8969_RS16255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M8969_RS16260	COG1141	Ferredoxin
M8969_RS16265	COG4955	Helix-turn-helix domain
M8969_RS16270	COG0514	ATP-dependent DNA helicase (RecQ)
M8969_RS16275	COG1266	CAAX protease self-immunity
M8969_RS16280	COG1388	LysM domain
M8969_RS16290	COG1408	metallophosphoesterase
M8969_RS16295	COG4862	establishment of competence for transformation
M8969_RS16300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8969_RS16305	COG0492	ferredoxin-NADP+ reductase activity
M8969_RS16310	COG2339	peptidase activity
M8969_RS16315	COG3773	Cell wall hydrolase
M8969_RS16315	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS16320	COG2959	enzyme of heme biosynthesis
M8969_RS16325	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M8969_RS16340	COG0539	negative regulation of cytoplasmic translation
M8969_RS16380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8969_RS16385	COG0776	regulation of translation
M8969_RS16400	COG0142	geranyltranstransferase activity
M8969_RS16410	COG0142	geranyltranstransferase activity
M8969_RS16415	COG0105	UTP biosynthetic process
M8969_RS16420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M8969_RS16435	COG4401	Chorismate mutase type I
M8969_RS16440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8969_RS16475	COG0287	Prephenate dehydrogenase
M8969_RS16485	COG0457	Tetratricopeptide repeat
M8969_RS16500	COG0723	plastoquinol--plastocyanin reductase activity
M8969_RS16505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8969_RS16510	COG2010	Cytochrome c
M8969_RS16510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8969_RS16515	COG4347	Protein of unknown function (DUF1405)
M8969_RS16530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS16535	COG1694	Mazg nucleotide pyrophosphohydrolase
M8969_RS16550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8969_RS16555	COG0438	transferase activity, transferring glycosyl groups
M8969_RS16585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M8969_RS16585	COG1199	ATP-dependent helicase activity
M8969_RS16595	COG5353	protein conserved in bacteria
M8969_RS16600	COG0436	Aminotransferase
M8969_RS16610	COG3935	DnaD domain protein
M8969_RS16615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8969_RS16625	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8969_RS16625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8969_RS16665	COG0071	Belongs to the small heat shock protein (HSP20) family
M8969_RS16670	COG2190	(PTS) system
M8969_RS16675	COG1205	dead DEAH box helicase
M8969_RS16675	COG1111	helicase
M8969_RS16680	COG3359	exonuclease
M8969_RS16710	COG0116	Belongs to the methyltransferase superfamily
M8969_RS16725	COG1199	ATP-dependent helicase activity
M8969_RS16730	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M8969_RS16740	COG2233	PERMEase
M8969_RS16750	COG1335	isochorismatase
M8969_RS16775	COG3424	synthase
M8969_RS16780	COG1755	Isoprenylcysteine carboxyl methyltransferase
M8969_RS16790	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8969_RS16805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8969_RS16815	COG0328	RNA-DNA hybrid ribonuclease activity
M8969_RS16820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M8969_RS16825	COG0328	RNA-DNA hybrid ribonuclease activity
M8969_RS16845	COG1278	Cold shock
M8969_RS16855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8969_RS16865	COG0386	Belongs to the glutathione peroxidase family
M8969_RS16870	COG1418	mRNA catabolic process
M8969_RS16875	COG1413	lyase activity
M8969_RS16890	COG2136	Putative SAM-dependent methyltransferase
M8969_RS16890	COG2521	methyltransferase
M8969_RS16905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8969_RS16910	COG0204	Acyl-transferase
M8969_RS16915	COG1272	protein, Hemolysin III
M8969_RS16920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M8969_RS16925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8969_RS16935	COG1999	signal sequence binding
M8969_RS16940	COG2755	lipolytic protein G-D-S-L family
M8969_RS16945	COG4698	Protein conserved in bacteria
M8969_RS16950	COG1846	Transcriptional regulator
M8969_RS16975	COG1525	nuclease
M8969_RS16980	COG4282	regulation of fungal-type cell wall biogenesis
M8969_RS16985	COG5444	nuclease activity
M8969_RS17005	COG3391	amine dehydrogenase activity
M8969_RS17015	COG0457	Tetratricopeptide repeat
M8969_RS17050	COG1086	Polysaccharide biosynthesis protein
M8969_RS17060	COG4641	Protein conserved in bacteria
M8969_RS17075	COG0463	Glycosyl transferase, family 2
M8969_RS17080	COG0456	acetyltransferase
M8969_RS17090	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M8969_RS17095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8969_RS17100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8969_RS17105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8969_RS17110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8969_RS17115	COG0456	acetyltransferase
M8969_RS17120	COG1509	lysine 2,3-aminomutase activity
M8969_RS17150	COG0671	phosphoesterase, PA-phosphatase related
M8969_RS17170	COG1876	peptidase activity
M8969_RS17180	COG2226	methyltransferase
M8969_RS17185	COG0793	Belongs to the peptidase S41A family
M8969_RS17185	COG3409	Peptidoglycan-binding domain 1 protein
M8969_RS17190	COG2188	Transcriptional regulator
M8969_RS17195	COG2723	6-phospho-beta-galactosidase activity
M8969_RS17205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8969_RS17215	COG0346	lactoylglutathione lyase activity
M8969_RS17220	COG0400	carboxylic ester hydrolase activity
M8969_RS17225	COG0778	Nitroreductase
M8969_RS17230	COG1733	regulation of RNA biosynthetic process
M8969_RS17240	COG1942	4-Oxalocrotonate Tautomerase
M8969_RS17255	COG2962	Rard protein
M8969_RS17265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8969_RS17270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8969_RS17275	COG1366	Belongs to the anti-sigma-factor antagonist family
M8969_RS17280	COG0534	Mate efflux family protein
M8969_RS17285	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8969_RS17290	COG1819	glycosyl
M8969_RS17295	COG1388	LysM domain
M8969_RS17295	COG0791	NLP P60 protein
M8969_RS17300	COG2032	superoxide dismutase activity
M8969_RS17305	COG0714	Associated with various cellular activities
M8969_RS17310	COG4548	von Willebrand factor, type A
M8969_RS17320	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8969_RS17325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS17330	COG0385	Bile acid
M8969_RS17335	COG0733	neurotransmitter:sodium symporter activity
M8969_RS17340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8969_RS17345	COG1657	PFAM Prenyltransferase squalene oxidase
M8969_RS17350	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS17380	COG0071	Belongs to the small heat shock protein (HSP20) family
M8969_RS17395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8969_RS17400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M8969_RS17410	COG0514	ATP-dependent DNA helicase (RecQ)
M8969_RS17415	COG1388	LysM domain
M8969_RS17415	COG3584	3D domain protein
M8969_RS17425	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8969_RS17440	COG2322	membrane
M8969_RS17445	COG0741	lytic transglycosylase activity
M8969_RS17450	COG0640	Transcriptional regulator
M8969_RS17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8969_RS17465	COG1309	transcriptional regulator
M8969_RS17470	COG2207	Transcriptional regulator
M8969_RS17470	COG0662	Cupin 2, conserved barrel domain protein
M8969_RS17475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8969_RS17480	COG5444	nuclease activity
M8969_RS17510	COG0243	molybdopterin cofactor binding
M8969_RS17515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8969_RS17520	COG1070	Carbohydrate kinase
M8969_RS17525	COG2814	Major facilitator Superfamily
M8969_RS17535	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8969_RS17540	COG0300	oxidoreductase activity
M8969_RS17555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8969_RS17560	COG0583	DNA-binding transcription factor activity
M8969_RS17565	COG0067	glutamate synthase
M8969_RS17565	COG0069	glutamate synthase activity
M8969_RS17565	COG0070	glutamate synthase
M8969_RS17570	COG0493	'glutamate synthase
M8969_RS17575	COG0604	alcohol dehydrogenase
M8969_RS17585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M8969_RS17590	COG0640	Transcriptional regulator
M8969_RS17595	COG2814	Major facilitator Superfamily
M8969_RS17600	COG0405	Gamma-glutamyltransferase
M8969_RS17605	COG0166	Belongs to the GPI family
M8969_RS17610	COG0582	viral genome integration into host DNA
M8969_RS17625	COG0534	Mate efflux family protein
M8969_RS17630	COG2017	converts alpha-aldose to the beta-anomer
M8969_RS17635	COG2027	D-alanyl-D-alanine carboxypeptidase
M8969_RS17650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8969_RS17660	COG3279	Response regulator of the LytR AlgR family
M8969_RS17680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M8969_RS17685	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M8969_RS17690	COG4988	ABC transporter
M8969_RS17695	COG1294	oxidase, subunit
M8969_RS17700	COG1271	oxidase subunit
M8969_RS17705	COG3493	citrate carrier protein
M8969_RS17710	COG0726	polysaccharide deacetylase
M8969_RS17715	COG3842	ATPase activity
M8969_RS17720	COG2508	Transcriptional regulator
M8969_RS17725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS17735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8969_RS17750	COG4894	glucomannan catabolic process
M8969_RS17755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M8969_RS17760	COG0500	methyltransferase
M8969_RS17765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8969_RS17780	COG0753	catalase activity
M8969_RS17780	COG0693	protein deglycase activity
M8969_RS17785	COG2851	Citrate transporter
M8969_RS17790	COG2273	Hydrolase Family 16
M8969_RS17800	COG2270	Major facilitator Superfamily
M8969_RS17805	COG0513	Belongs to the DEAD box helicase family
M8969_RS17815	COG0697	spore germination
M8969_RS17820	COG0589	response to stress
M8969_RS17880	COG3507	Belongs to the glycosyl hydrolase 43 family
M8969_RS17905	COG0010	Belongs to the arginase family
M8969_RS17910	COG0833	amino acid
M8969_RS17915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M8969_RS17920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8969_RS17930	COG2390	Transcriptional regulator
M8969_RS17935	COG0561	phosphatase activity
M8969_RS17965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8969_RS17970	COG5294	Protein conserved in bacteria
M8969_RS17975	COG0577	efflux transmembrane transporter activity
M8969_RS17980	COG1136	(ABC) transporter
M8969_RS17985	COG2205	protein histidine kinase activity
M8969_RS17990	COG0745	RESPONSE REGULATOR receiver
M8969_RS17995	COG2205	protein histidine kinase activity
M8969_RS18000	COG0745	RESPONSE REGULATOR receiver
M8969_RS18030	COG1082	Xylose isomerase domain protein TIM barrel
M8969_RS18040	COG2814	Major facilitator Superfamily
M8969_RS18070	COG1349	DNA-binding transcription factor activity
M8969_RS18075	COG0667	Aldo Keto reductase
M8969_RS18080	COG2814	Major facilitator Superfamily
M8969_RS18095	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS18100	COG2197	response regulator
M8969_RS18105	COG4585	Histidine kinase
M8969_RS18110	COG3239	Fatty acid desaturase
M8969_RS18115	COG1309	transcriptional regulator
M8969_RS18120	COG1012	belongs to the aldehyde dehydrogenase family
M8969_RS18125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M8969_RS18135	COG0640	Transcriptional regulator
M8969_RS18140	COG2814	Major facilitator Superfamily
M8969_RS18145	COG1714	RDD family
M8969_RS18155	COG0450	alkyl hydroperoxide reductase
M8969_RS18160	COG3634	alkyl hydroperoxide reductase activity
M8969_RS18165	COG3177	Filamentation induced by cAMP protein fic
M8969_RS18170	COG1113	amino acid transport
M8969_RS18180	COG2080	2 iron, 2 sulfur cluster binding
M8969_RS18195	COG2068	MobA-Related Protein
M8969_RS18200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M8969_RS18255	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8969_RS18260	COG0667	Aldo Keto reductase
M8969_RS18265	COG0456	acetyltransferase
M8969_RS18270	COG0457	Tetratricopeptide repeat
M8969_RS18275	COG0010	Belongs to the arginase family
M8969_RS18280	COG0833	amino acid
M8969_RS18285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8969_RS18290	COG5658	integral membrane protein
M8969_RS18295	COG0640	Transcriptional regulator
M8969_RS18300	COG3829	transcription factor binding
M8969_RS18310	COG0488	(ABC) transporter
M8969_RS18325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8969_RS18330	COG3850	Histidine kinase
M8969_RS18330	COG5002	protein histidine kinase activity
M8969_RS18340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8969_RS18345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M8969_RS18350	COG4853	Protein conserved in bacteria
M8969_RS18355	COG4863	YycH protein
M8969_RS18360	COG5002	protein histidine kinase activity
M8969_RS18365	COG0745	RESPONSE REGULATOR receiver
M8969_RS18395	COG0346	lactoylglutathione lyase activity
M8969_RS18400	COG0305	Participates in initiation and elongation during chromosome replication
M8969_RS18415	COG3093	addiction module antidote protein HigA
M8969_RS18420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8969_RS18425	COG0297	glycogen (starch) synthase activity
M8969_RS18435	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M8969_RS18440	COG0438	transferase activity, transferring glycosyl groups
M8969_RS18460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M8969_RS18465	COG4241	membrane
M8969_RS18475	COG5577	PFAM Coat F domain
M8969_RS18480	COG1733	regulation of RNA biosynthetic process
M8969_RS18490	COG0697	spore germination
M8969_RS18495	COG1621	beta-fructofuranosidase activity
M8969_RS18500	COG1621	beta-fructofuranosidase activity
M8969_RS18510	COG2318	DinB family
M8969_RS18515	COG2211	Major facilitator Superfamily
M8969_RS18525	COG0778	Nitroreductase
M8969_RS18535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8969_RS18540	COG1846	Transcriptional regulator
M8969_RS18545	COG2153	protein acetylation
M8969_RS18555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8969_RS18560	COG0583	DNA-binding transcription factor activity
M8969_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
M8969_RS18570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8969_RS18575	COG0697	spore germination
M8969_RS18605	COG1331	Highly conserved protein containing a thioredoxin domain
M8969_RS18610	COG1266	CAAX protease self-immunity
M8969_RS18615	COG0477	Major facilitator Superfamily
M8969_RS18615	COG2814	Major facilitator Superfamily
M8969_RS18620	COG0346	lactoylglutathione lyase activity
M8969_RS18625	COG1609	Transcriptional regulator
M8969_RS18630	COG0708	Exodeoxyribonuclease III
M8969_RS18635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8969_RS18640	COG2169	Transcriptional regulator
M8969_RS18650	COG0629	single-stranded DNA binding
M8969_RS18660	COG0012	GTP binding
M8969_RS18665	COG0243	molybdopterin cofactor binding
M8969_RS18670	COG4481	Protein conserved in bacteria
M8969_RS18675	COG3949	Membrane
M8969_RS18690	COG1475	DNA binding
M8969_RS18695	COG1192	Involved in chromosome partitioning
M8969_RS18720	COG1847	R3H domain protein
M8969_RS18725	COG0706	membrane insertase activity
M8969_RS18745	COG0592	DNA-directed DNA polymerase activity
M8969_RS18750	COG2501	S4 domain
M8969_RS18765	COG0187	DNA topoisomerase II activity
M8969_RS18770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8969_RS18775	COG4463	regulation of RNA biosynthetic process
M8969_RS18780	COG3880	PFAM UvrB UvrC protein
M8969_RS18790	COG0542	response to heat
M8969_RS18795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M8969_RS18800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M8969_RS18805	COG4956	integral membrane protein (PIN domain superfamily)
M8969_RS18825	COG1045	serine acetyltransferase
M8969_RS18835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M8969_RS18840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8969_RS18845	COG3688	RNA-binding protein containing a PIN domain
M8969_RS18850	COG1595	DNA-templated transcription, initiation
M8969_RS18860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8969_RS18865	COG0250	Participates in transcription elongation, termination and antitermination
M8969_RS18890	COG2813	Specifically methylates the guanine in position
M8969_RS18905	COG1358	cellular component organization or biogenesis
M8969_RS18930	COG0596	Alpha beta hydrolase
M8969_RS19025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M8969_RS19040	COG0201	protein transport
M8969_RS19050	COG0024	Methionine aminopeptidase
M8969_RS19065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M8969_RS19090	COG1122	ATPase activity
M8969_RS19095	COG1122	ATPase activity
M8969_RS19100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8969_RS19120	COG2226	methyltransferase
M8969_RS19125	COG2318	DinB family
M8969_RS19135	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8969_RS19140	COG0489	protein tyrosine kinase activity
M8969_RS19150	COG2194	sulfuric ester hydrolase activity
M8969_RS19155	COG0726	polysaccharide deacetylase
M8969_RS19165	COG0516	GMP reductase activity
M8969_RS19165	COG0517	IMP dehydrogenase activity
M8969_RS19170	COG1686	Belongs to the peptidase S11 family
M8969_RS19190	COG1929	Belongs to the glycerate kinase type-1 family
M8969_RS19200	COG1428	Deoxynucleoside kinase
M8969_RS19205	COG1428	Deoxynucleoside kinase
M8969_RS19210	COG1388	LysM domain
M8969_RS19210	COG3858	chitin binding
M8969_RS19215	COG1335	isochorismatase
M8969_RS19220	COG0590	tRNA wobble adenosine to inosine editing
M8969_RS19230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M8969_RS19235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M8969_RS19240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO