locus-tag	class	description
M8961_RS00015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS00015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8961_RS00025	COG1649	PFAM Uncharacterised BCR, COG1649
M8961_RS00030	COG1960	acyl-CoA dehydrogenase activity
M8961_RS00035	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS00040	COG0439	Biotin carboxylase
M8961_RS00045	COG0511	ligase activity, forming carbon-carbon bonds
M8961_RS00050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M8961_RS00055	COG1024	Enoyl-CoA hydratase
M8961_RS00060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8961_RS00065	COG0586	Pfam SNARE associated Golgi protein
M8961_RS00070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8961_RS00075	COG2246	polysaccharide biosynthetic process
M8961_RS00085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8961_RS00105	COG2124	cytochrome p450
M8961_RS00110	COG2610	gluconate transmembrane transporter activity
M8961_RS00115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8961_RS00120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8961_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00150	COG3507	Belongs to the glycosyl hydrolase 43 family
M8961_RS00160	COG0745	RESPONSE REGULATOR receiver
M8961_RS00165	COG2205	protein histidine kinase activity
M8961_RS00210	COG2271	Major facilitator Superfamily
M8961_RS00215	COG1609	Transcriptional regulator
M8961_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00225	COG1312	Catalyzes the dehydration of D-mannonate
M8961_RS00230	COG0800	Aldolase
M8961_RS00235	COG1063	alcohol dehydrogenase
M8961_RS00245	COG1115	amino acid carrier protein
M8961_RS00255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8961_RS00260	COG0187	DNA topoisomerase II activity
M8961_RS00265	COG1832	CoA-binding protein
M8961_RS00275	COG4841	protein insertion into membrane
M8961_RS00285	COG0824	Thioesterase
M8961_RS00305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS00310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M8961_RS00325	COG0071	Belongs to the small heat shock protein (HSP20) family
M8961_RS00335	COG4846	Membrane protein involved in cytochrome C biogenesis
M8961_RS00340	COG2201	protein-glutamate methylesterase activity
M8961_RS00345	COG0785	Cytochrome C biogenesis protein
M8961_RS00365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M8961_RS00375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M8961_RS00410	COG4195	phage-related replication protein
M8961_RS00420	COG0756	dUTP diphosphatase activity
M8961_RS00425	COG5434	Belongs to the glycosyl hydrolase 28 family
M8961_RS00445	COG3397	chitin binding
M8961_RS00480	COG0456	acetyltransferase
M8961_RS00495	COG1064	alcohol dehydrogenase
M8961_RS00500	COG2318	DinB family
M8961_RS00525	COG3848	Pyruvate phosphate dikinase
M8961_RS00525	COG0574	Belongs to the PEP-utilizing enzyme family
M8961_RS00530	COG1070	Carbohydrate kinase
M8961_RS00545	COG3507	Belongs to the glycosyl hydrolase 43 family
M8961_RS00550	COG2211	Major facilitator Superfamily
M8961_RS00575	COG0174	glutamine synthetase
M8961_RS00580	COG0789	Transcriptional regulator
M8961_RS00585	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M8961_RS00590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M8961_RS00595	COG0464	growth
M8961_RS00600	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS00605	COG4112	unkown
M8961_RS00610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8961_RS00615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8961_RS00655	COG2076	Multidrug Resistance protein
M8961_RS00665	COG1764	response to oxidative stress
M8961_RS00670	COG4195	phage-related replication protein
M8961_RS00680	COG1404	Belongs to the peptidase S8 family
M8961_RS00690	COG3619	membrane
M8961_RS00695	COG3209	COG3209 Rhs family protein
M8961_RS00700	COG2124	cytochrome p450
M8961_RS00705	COG3321	synthase
M8961_RS00705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M8961_RS00705	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M8961_RS00705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS00710	COG4221	oxidoreductase activity
M8961_RS00710	COG3321	synthase
M8961_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS00715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00715	COG3321	synthase
M8961_RS00715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS00715	COG3321	synthase
M8961_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS00715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS00715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS00715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS00720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS00720	COG3321	synthase
M8961_RS00720	COG4221	oxidoreductase activity
M8961_RS00720	COG0300	oxidoreductase activity
M8961_RS00725	COG3321	synthase
M8961_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS00725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS00725	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS00725	COG0300	oxidoreductase activity
M8961_RS00730	COG1024	Enoyl-CoA hydratase
M8961_RS00735	COG1024	Enoyl-CoA hydratase
M8961_RS00740	COG3425	synthase
M8961_RS00745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS00790	COG4550	Control of competence regulator ComK, YlbF/YmcA
M8961_RS00810	COG2359	stage V sporulation protein S
M8961_RS00815	COG1692	metallophosphoesterase
M8961_RS00825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8961_RS00840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M8961_RS00845	COG1426	Protein conserved in bacteria
M8961_RS00860	COG0300	oxidoreductase activity
M8961_RS00865	COG0612	Peptidase, M16
M8961_RS00870	COG0612	Peptidase, M16
M8961_RS00875	COG1033	growth of symbiont in host cell
M8961_RS00875	COG2409	Drug exporters of the RND superfamily
M8961_RS00880	COG1846	Transcriptional regulator
M8961_RS00885	COG2814	Major facilitator Superfamily
M8961_RS00890	COG2188	Transcriptional regulator
M8961_RS00895	COG1674	ftsk spoiiie
M8961_RS00895	COG4980	gas vesicle protein
M8961_RS00905	COG0740	serine-type endopeptidase activity
M8961_RS00910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8961_RS00920	COG0527	aspartate kinase activity
M8961_RS00925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M8961_RS00930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8961_RS00935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8961_RS00940	COG1873	PFAM PRC-barrel domain
M8961_RS00945	COG0612	Peptidase, M16
M8961_RS00950	COG0726	polysaccharide deacetylase
M8961_RS00965	COG0196	riboflavin kinase activity
M8961_RS00980	COG1550	Protein conserved in bacteria
M8961_RS00990	COG1358	cellular component organization or biogenesis
M8961_RS00995	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M8961_RS01000	COG0195	Participates in both transcription termination and antitermination
M8961_RS01020	COG0750	zinc metalloprotease
M8961_RS01030	COG4589	Belongs to the CDS family
M8961_RS01035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M8961_RS01065	COG1191	sigma factor activity
M8961_RS01075	COG1776	CheC inhibitor of MCP methylation
M8961_RS01080	COG0835	chemotaxis
M8961_RS01085	COG0643	Histidine kinase
M8961_RS01085	COG2198	Histidine kinase
M8961_RS01090	COG2201	protein-glutamate methylesterase activity
M8961_RS01095	COG0455	bacterial-type flagellum organization
M8961_RS01100	COG1419	protein localization to endoplasmic reticulum
M8961_RS01105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8961_RS01110	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M8961_RS01115	COG1684	flagellar biosynthetic protein fliR
M8961_RS01120	COG1987	bacterial-type flagellum assembly
M8961_RS01125	COG1338	Plays a role in the flagellum-specific transport system
M8961_RS01130	COG3190	flagellar
M8961_RS01135	COG2201	protein-glutamate methylesterase activity
M8961_RS01140	COG1776	CheC inhibitor of MCP methylation
M8961_RS01140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8961_RS01145	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8961_RS01150	COG1580	Controls the rotational direction of flagella during chemotaxis
M8961_RS01155	COG1582	Flagellar protein (FlbD)
M8961_RS01160	COG4786	Flagellar basal body rod
M8961_RS01165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M8961_RS01170	COG3144	bacterial-type flagellum assembly
M8961_RS01175	COG3334	PFAM MgtE intracellular
M8961_RS01180	COG2882	bacterial-type flagellum organization
M8961_RS01185	COG1157	protein secretion by the type III secretion system
M8961_RS01190	COG1317	bacterial-type flagellum organization
M8961_RS01195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M8961_RS01200	COG1766	The M ring may be actively involved in energy transduction
M8961_RS01205	COG1677	Flagellar hook-basal body complex protein FliE
M8961_RS01210	COG1558	bacterial-type flagellum-dependent cell motility
M8961_RS01215	COG1815	bacterial-type flagellum-dependent cell motility
M8961_RS01235	COG4974	Belongs to the 'phage' integrase family
M8961_RS01245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8961_RS01250	COG0758	DNA mediated transformation
M8961_RS01255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M8961_RS01265	COG2257	FlhB HrpN YscU SpaS Family
M8961_RS01280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8961_RS01305	COG1837	Belongs to the UPF0109 family
M8961_RS01315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M8961_RS01330	COG0552	protein localization to endoplasmic reticulum
M8961_RS01335	COG1196	nuclear chromosome segregation
M8961_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS01355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8961_RS01370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M8961_RS01375	COG1760	l-serine dehydratase
M8961_RS01380	COG1760	l-serine dehydratase
M8961_RS01385	COG1461	Dihydroxyacetone kinase
M8961_RS01390	COG1302	Protein conserved in bacteria
M8961_RS01405	COG1564	THIamine pyrophosphokinase
M8961_RS01410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M8961_RS01420	COG2815	serine threonine protein kinase
M8961_RS01420	COG0515	serine threonine protein kinase
M8961_RS01425	COG0631	protein serine/threonine phosphatase activity
M8961_RS01435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M8961_RS01435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8961_RS01445	COG0242	peptide deformylase activity
M8961_RS01450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8961_RS01455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8961_RS01465	COG0194	GDP metabolic process
M8961_RS01475	COG1561	YicC-like family, N-terminal region
M8961_RS01480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M8961_RS01490	COG1648	precorrin-2 dehydrogenase activity
M8961_RS01495	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M8961_RS01500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8961_RS01515	COG0306	phosphate transporter
M8961_RS01525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M8961_RS01530	COG0284	orotidine-5'-phosphate decarboxylase activity
M8961_RS01545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8961_RS01550	COG0505	Belongs to the CarA family
M8961_RS01555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M8961_RS01565	COG2233	PERMEase
M8961_RS01575	COG0564	pseudouridine synthase activity
M8961_RS01585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8961_RS01590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M8961_RS01595	COG3599	regulation of cell shape
M8961_RS01600	COG2302	S4 RNA-binding domain
M8961_RS01605	COG0762	integral membrane protein
M8961_RS01615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M8961_RS01620	COG1496	oxidoreductase activity
M8961_RS01625	COG1873	PFAM PRC-barrel domain
M8961_RS01630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8961_RS01635	COG1119	ATPase activity
M8961_RS01640	COG1191	sigma factor activity
M8961_RS01645	COG1191	sigma factor activity
M8961_RS01655	COG1404	Belongs to the peptidase S8 family
M8961_RS01655	COG4412	M6 family metalloprotease domain protein
M8961_RS01660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M8961_RS01665	COG0849	cell division
M8961_RS01670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M8961_RS01685	COG0772	Belongs to the SEDS family
M8961_RS01705	COG0768	penicillin binding
M8961_RS01710	COG0768	penicillin binding
M8961_RS01715	COG4839	cell division protein FtsL
M8961_RS01735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8961_RS01755	COG1399	metal-binding, possibly nucleic acid-binding protein
M8961_RS01765	COG3480	Lon protease (S16) C-terminal proteolytic domain
M8961_RS01770	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8961_RS01775	COG3314	Sporulation integral membrane protein YlbJ
M8961_RS01785	COG0742	ribosomal rna small subunit methyltransferase
M8961_RS01795	COG3679	Belongs to the UPF0342 family
M8961_RS01810	COG2340	Cysteine-rich secretory protein family
M8961_RS01815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M8961_RS01825	COG3336	cytochrome c oxidase
M8961_RS01830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M8961_RS01835	COG1845	cytochrome c oxidase, subunit III
M8961_RS01840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8961_RS01845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8961_RS01845	COG2010	Cytochrome c
M8961_RS01860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M8961_RS01865	COG0772	Belongs to the SEDS family
M8961_RS01875	COG2066	Belongs to the glutaminase family
M8961_RS01880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8961_RS01885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M8961_RS01895	COG4896	Protein conserved in bacteria
M8961_RS01905	COG1217	gtp-binding protein TYPA
M8961_RS01925	COG1595	DNA-templated transcription, initiation
M8961_RS01940	COG3227	Zinc metalloprotease (Elastase)
M8961_RS01950	COG0483	inositol monophosphate 1-phosphatase activity
M8961_RS01970	COG1982	Orn Lys Arg decarboxylase major
M8961_RS01985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS01990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8961_RS01995	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8961_RS02000	COG0022	dehydrogenase e1 component
M8961_RS02005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8961_RS02010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8961_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS02015	COG3321	synthase
M8961_RS02015	COG4221	oxidoreductase activity
M8961_RS02020	COG3321	synthase
M8961_RS02020	COG4221	oxidoreductase activity
M8961_RS02020	COG0300	oxidoreductase activity
M8961_RS02020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS02025	COG4221	oxidoreductase activity
M8961_RS02025	COG3321	synthase
M8961_RS02025	COG0300	oxidoreductase activity
M8961_RS02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS02030	COG4221	oxidoreductase activity
M8961_RS02030	COG3321	synthase
M8961_RS02030	COG0300	oxidoreductase activity
M8961_RS02030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS02035	COG4221	oxidoreductase activity
M8961_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS02035	COG3321	synthase
M8961_RS02040	COG4221	oxidoreductase activity
M8961_RS02040	COG3321	synthase
M8961_RS02040	COG0300	oxidoreductase activity
M8961_RS02040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS02045	COG4221	oxidoreductase activity
M8961_RS02045	COG3321	synthase
M8961_RS02045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS02055	COG0497	DNA recombination
M8961_RS02065	COG0242	peptide deformylase activity
M8961_RS02070	COG0561	phosphatase activity
M8961_RS02080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8961_RS02090	COG0569	domain protein
M8961_RS02095	COG2105	PFAM AIG2 family protein
M8961_RS02095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M8961_RS02100	COG3852	Histidine kinase
M8961_RS02105	COG2002	toxin-antitoxin pair type II binding
M8961_RS02110	COG1077	Cell shape determining protein MreB Mrl
M8961_RS02120	COG2309	aminopeptidase activity
M8961_RS02125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8961_RS02130	COG0488	(ABC) transporter
M8961_RS02140	COG0681	Belongs to the peptidase S26 family
M8961_RS02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS02145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8961_RS02145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8961_RS02150	COG1105	Belongs to the carbohydrate kinase PfkB family
M8961_RS02155	COG1349	DNA-binding transcription factor activity
M8961_RS02160	COG0577	efflux transmembrane transporter activity
M8961_RS02165	COG1136	(ABC) transporter
M8961_RS02170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M8961_RS02180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M8961_RS02185	COG0314	molybdopterin synthase activity
M8961_RS02190	COG1763	Mo-molybdopterin cofactor biosynthetic process
M8961_RS02195	COG0303	'Molybdopterin
M8961_RS02200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8961_RS02220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS02225	COG0668	transmembrane transport
M8961_RS02245	COG0716	FMN binding
M8961_RS02255	COG0716	FMN binding
M8961_RS02260	COG0583	DNA-binding transcription factor activity
M8961_RS02265	COG0517	IMP dehydrogenase activity
M8961_RS02275	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M8961_RS02280	COG4703	Protein of unknown function (DUF1797)
M8961_RS02285	COG2200	EAL domain
M8961_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS02300	COG1408	metallophosphoesterase
M8961_RS02305	COG1376	ErfK ybiS ycfS ynhG family protein
M8961_RS02310	COG2814	Major facilitator Superfamily
M8961_RS02320	COG0784	Response regulator, receiver
M8961_RS02320	COG0835	chemotaxis
M8961_RS02330	COG0436	Aminotransferase
M8961_RS02335	COG4191	Histidine kinase
M8961_RS02340	COG0768	penicillin binding
M8961_RS02345	COG2340	Cysteine-rich secretory protein family
M8961_RS02360	COG2084	Dehydrogenase
M8961_RS02365	COG0840	transmembrane signaling receptor activity
M8961_RS02370	COG1533	DNA photolyase activity
M8961_RS02380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8961_RS02385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS02390	COG1263	PTS System
M8961_RS02390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS02390	COG2190	(PTS) system
M8961_RS02395	COG3711	transcriptional antiterminator
M8961_RS02400	COG1609	Transcriptional regulator
M8961_RS02405	COG0006	proline dipeptidase activity
M8961_RS02410	COG2217	Heavy metal translocating P-type atpase
M8961_RS02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS02420	COG2244	polysaccharide biosynthetic process
M8961_RS02425	COG3773	Cell wall hydrolase
M8961_RS02435	COG4873	Protein conserved in bacteria
M8961_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS02455	COG1733	regulation of RNA biosynthetic process
M8961_RS02470	COG0602	queuosine metabolic process
M8961_RS02475	COG0720	synthase
M8961_RS02490	COG3949	Membrane
M8961_RS02495	COG0542	response to heat
M8961_RS02500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8961_RS02505	COG1360	Flagellar Motor Protein
M8961_RS02510	COG1846	Transcriptional regulator
M8961_RS02515	COG3852	Histidine kinase
M8961_RS02545	COG0436	Aminotransferase
M8961_RS02550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8961_RS02570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8961_RS02575	COG5002	protein histidine kinase activity
M8961_RS02580	COG3594	Acyltransferase
M8961_RS02590	COG2323	membrane
M8961_RS02595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8961_RS02620	COG1191	sigma factor activity
M8961_RS02630	COG0586	Pfam SNARE associated Golgi protein
M8961_RS02635	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M8961_RS02640	COG1793	dna ligase
M8961_RS02640	COG3285	dna ligase
M8961_RS02645	COG0726	polysaccharide deacetylase
M8961_RS02650	COG1846	Transcriptional regulator
M8961_RS02665	COG0789	Transcriptional regulator
M8961_RS02670	COG2239	Acts as a magnesium transporter
M8961_RS02680	COG3858	chitin binding
M8961_RS02680	COG1388	LysM domain
M8961_RS02685	COG4721	ABC-type cobalt transport system, permease component
M8961_RS02690	COG1122	ATPase activity
M8961_RS02695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8961_RS02700	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS02705	COG1404	Belongs to the peptidase S8 family
M8961_RS02715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8961_RS02720	COG2814	Major facilitator Superfamily
M8961_RS02730	COG0463	Glycosyl transferase, family 2
M8961_RS02730	COG0457	Tetratricopeptide repeat
M8961_RS02745	COG1764	response to oxidative stress
M8961_RS02750	COG1846	Transcriptional regulator
M8961_RS02755	COG1764	response to oxidative stress
M8961_RS02765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8961_RS02770	COG0788	formyltetrahydrofolate deformylase activity
M8961_RS02775	COG2076	Multidrug Resistance protein
M8961_RS02780	COG2076	Multidrug Resistance protein
M8961_RS02785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8961_RS02790	COG1607	acyl-coa hydrolase
M8961_RS02795	COG1834	amidinotransferase
M8961_RS02800	COG2706	6-phosphogluconolactonase activity
M8961_RS02805	COG4608	Belongs to the ABC transporter superfamily
M8961_RS02810	COG0791	NLP P60 protein
M8961_RS02815	COG4948	Mandelate Racemase Muconate Lactonizing
M8961_RS02820	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8961_RS02825	COG4166	transmembrane transport
M8961_RS02830	COG0444	Belongs to the ABC transporter superfamily
M8961_RS02835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8961_RS02840	COG0601	transmembrane transport
M8961_RS02845	COG2362	D-Aminopeptidase
M8961_RS02850	COG0477	Major facilitator Superfamily
M8961_RS02855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8961_RS02865	COG0463	Glycosyl transferase, family 2
M8961_RS02870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8961_RS02875	COG0346	lactoylglutathione lyase activity
M8961_RS02880	COG0531	amino acid
M8961_RS02885	COG1392	Phosphate transport regulator
M8961_RS02890	COG0306	phosphate transporter
M8961_RS02910	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS02910	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8961_RS02945	COG3728	DNA packaging
M8961_RS02945	COG5484	DNA packaging
M8961_RS02950	COG1595	DNA-templated transcription, initiation
M8961_RS02970	COG1484	DNA-dependent DNA replication
M8961_RS02985	COG1396	sequence-specific DNA binding
M8961_RS02990	COG2856	Zn peptidase
M8961_RS02995	COG4195	phage-related replication protein
M8961_RS03005	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS03005	COG1388	LysM domain
M8961_RS03005	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8961_RS03015	COG0457	Tetratricopeptide repeat
M8961_RS03020	COG2318	DinB family
M8961_RS03025	COG0730	response to heat
M8961_RS03030	COG2721	sulfolactate sulfo-lyase activity
M8961_RS03035	COG0246	Mannitol dehydrogenase
M8961_RS03040	COG1609	Transcriptional regulator
M8961_RS03045	COG2211	Major facilitator Superfamily
M8961_RS03055	COG1252	NADH dehydrogenase
M8961_RS03065	COG4297	protein containing double-stranded beta helix domain
M8961_RS03070	COG0697	spore germination
M8961_RS03075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8961_RS03080	COG0390	transport system, permease component
M8961_RS03085	COG1587	Uroporphyrinogen-III synthase
M8961_RS03095	COG1819	glycosyl
M8961_RS03100	COG2124	cytochrome p450
M8961_RS03105	COG2427	Protein of unknown function (DUF1641)
M8961_RS03110	COG3383	formate dehydrogenase (NAD+) activity
M8961_RS03120	COG2205	protein histidine kinase activity
M8961_RS03135	COG1285	pathogenesis
M8961_RS03165	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8961_RS03170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS03175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8961_RS03180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8961_RS03185	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8961_RS03195	COG1846	Transcriptional regulator
M8961_RS03200	COG0477	Major facilitator Superfamily
M8961_RS03205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8961_RS03210	COG2367	Beta-lactamase
M8961_RS03330	COG1757	Na H antiporter
M8961_RS03335	COG3340	Belongs to the peptidase S51 family
M8961_RS03345	COG0277	FAD linked oxidase domain protein
M8961_RS03360	COG0753	catalase activity
M8961_RS03370	COG1116	anion transmembrane transporter activity
M8961_RS03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8961_RS03380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8961_RS03400	COG1476	TRANSCRIPTIONal
M8961_RS03410	COG3382	B3 4 domain protein
M8961_RS03415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8961_RS03425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M8961_RS03430	COG0789	Transcriptional regulator
M8961_RS03435	COG1664	Polymer-forming cytoskeletal
M8961_RS03440	COG1664	Polymer-forming cytoskeletal
M8961_RS03445	COG2766	serine protein kinase
M8961_RS03455	COG1846	Transcriptional regulator
M8961_RS03460	COG1566	PFAM secretion protein HlyD family protein
M8961_RS03465	COG2814	Major facilitator Superfamily
M8961_RS03470	COG0655	NAD(P)H dehydrogenase (quinone) activity
M8961_RS03485	COG1725	Transcriptional regulator
M8961_RS03490	COG1131	(ABC) transporter
M8961_RS03495	COG1131	(ABC) transporter
M8961_RS03500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8961_RS03505	COG1278	Cold shock
M8961_RS03510	COG1464	Belongs to the NlpA lipoprotein family
M8961_RS03515	COG3706	GGDEF domain
M8961_RS03520	COG1823	symporter activity
M8961_RS03540	COG5577	PFAM Coat F domain
M8961_RS03555	COG3764	Sortase (surface protein transpeptidase)
M8961_RS03560	COG0564	pseudouridine synthase activity
M8961_RS03570	COG0517	IMP dehydrogenase activity
M8961_RS03575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8961_RS03580	COG3153	acetyltransferase
M8961_RS03580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M8961_RS03585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8961_RS03590	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M8961_RS03595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M8961_RS03605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M8961_RS03610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8961_RS03615	COG2203	Gaf domain
M8961_RS03615	COG4585	Histidine kinase
M8961_RS03620	COG2197	response regulator
M8961_RS03625	COG0431	NADPH-dependent FMN reductase
M8961_RS03640	COG1388	LysM domain
M8961_RS03640	COG0791	NLP P60 protein
M8961_RS03645	COG1959	2 iron, 2 sulfur cluster binding
M8961_RS03655	COG2719	SpoVR family
M8961_RS03660	COG1785	Belongs to the alkaline phosphatase family
M8961_RS03665	COG0791	NLP P60 protein
M8961_RS03665	COG1388	LysM domain
M8961_RS03670	COG0583	DNA-binding transcription factor activity
M8961_RS03675	COG0372	Belongs to the citrate synthase family
M8961_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS03685	COG0531	amino acid
M8961_RS03690	COG0733	neurotransmitter:sodium symporter activity
M8961_RS03705	COG1595	DNA-templated transcription, initiation
M8961_RS03710	COG0204	Acyl-transferase
M8961_RS03715	COG1253	flavin adenine dinucleotide binding
M8961_RS03720	COG0789	Transcriptional regulator
M8961_RS03725	COG0436	Aminotransferase
M8961_RS03730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8961_RS03735	COG1253	flavin adenine dinucleotide binding
M8961_RS03740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8961_RS03745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8961_RS03750	COG0584	glycerophosphoryl diester phosphodiesterase
M8961_RS03760	COG0668	transmembrane transport
M8961_RS03765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M8961_RS03770	COG0726	polysaccharide deacetylase
M8961_RS03775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8961_RS03780	COG3226	Transcriptional regulator
M8961_RS03790	COG0589	response to stress
M8961_RS03795	COG1132	(ABC) transporter
M8961_RS03800	COG1132	(ABC) transporter
M8961_RS03805	COG0702	epimerase
M8961_RS03825	COG0189	ligase activity
M8961_RS03830	COG0189	ligase activity
M8961_RS03845	COG4335	DNA alkylation repair
M8961_RS03850	COG0561	phosphatase activity
M8961_RS03855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8961_RS03865	COG0475	glutathione-regulated potassium exporter activity
M8961_RS03870	COG0490	domain, Protein
M8961_RS03880	COG1024	Enoyl-CoA hydratase
M8961_RS03890	COG4152	abc transporter atp-binding protein
M8961_RS03895	COG1668	transmembrane transport
M8961_RS03900	COG0420	3'-5' exonuclease activity
M8961_RS03905	COG4717	serine-type aminopeptidase activity
M8961_RS03920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8961_RS03955	COG4980	gas vesicle protein
M8961_RS03970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M8961_RS03975	COG0537	adenosine 5'-monophosphoramidase activity
M8961_RS03980	COG1131	(ABC) transporter
M8961_RS03985	COG4473	ABC transporter
M8961_RS03995	COG1473	amidohydrolase
M8961_RS04000	COG3069	C4-dicarboxylate transmembrane transporter activity
M8961_RS04005	COG2329	Antibiotic biosynthesis monooxygenase
M8961_RS04010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8961_RS04020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M8961_RS04025	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M8961_RS04030	COG1309	transcriptional regulator
M8961_RS04035	COG1511	domain protein
M8961_RS04040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8961_RS04050	COG1363	Peptidase, m42
M8961_RS04055	COG1301	dicarboxylic acid transport
M8961_RS04065	COG1234	tRNA 3'-trailer cleavage
M8961_RS04070	COG0095	Lipoate-protein ligase
M8961_RS04075	COG0702	epimerase
M8961_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS04090	COG0501	Belongs to the peptidase M48B family
M8961_RS04095	COG1404	Belongs to the peptidase S8 family
M8961_RS04100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M8961_RS04105	COG0406	alpha-ribazole phosphatase activity
M8961_RS04110	COG0183	Belongs to the thiolase family
M8961_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS04120	COG1268	BioY protein
M8961_RS04125	COG0840	transmembrane signaling receptor activity
M8961_RS04130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8961_RS04130	COG0723	plastoquinol--plastocyanin reductase activity
M8961_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS04145	COG4903	ComK protein
M8961_RS04155	COG5646	InterPro IPR014922
M8961_RS04180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8961_RS04195	COG0398	Pfam SNARE associated Golgi protein
M8961_RS04200	COG0681	Belongs to the peptidase S26 family
M8961_RS04205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8961_RS04210	COG1846	Transcriptional regulator
M8961_RS04215	COG3180	Ammonia monooxygenase
M8961_RS04220	COG2814	Major facilitator Superfamily
M8961_RS04230	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M8961_RS04235	COG2323	membrane
M8961_RS04250	COG0420	3'-5' exonuclease activity
M8961_RS04255	COG0419	ATPase involved in DNA repair
M8961_RS04260	COG1403	HNH endonuclease
M8961_RS04300	COG0179	Fumarylacetoacetate (FAA) hydrolase
M8961_RS04320	COG0367	asparagine synthase
M8961_RS04325	COG1562	ergosterol biosynthetic process
M8961_RS04330	COG0534	Mate efflux family protein
M8961_RS04335	COG2207	Transcriptional regulator
M8961_RS04335	COG1917	Cupin 2, conserved barrel domain protein
M8961_RS04340	COG2318	DinB family
M8961_RS04345	COG1357	PFAM Pentapeptide repeats (8 copies)
M8961_RS04350	COG2153	protein acetylation
M8961_RS04355	COG0646	methionine synthase
M8961_RS04355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M8961_RS04365	COG2996	Protein conserved in bacteria
M8961_RS04370	COG1744	ABC transporter substrate-binding protein PnrA-like
M8961_RS04375	COG0840	transmembrane signaling receptor activity
M8961_RS04380	COG2124	cytochrome p450
M8961_RS04390	COG1307	EDD domain protein, DegV family
M8961_RS04395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS04415	COG0561	phosphatase activity
M8961_RS04420	COG1073	alpha beta
M8961_RS04425	COG2151	metal-sulfur cluster biosynthetic enzyme
M8961_RS04435	COG0277	FAD linked oxidase domain protein
M8961_RS04440	COG2271	Major facilitator Superfamily
M8961_RS04450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M8961_RS04460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8961_RS04465	COG0505	Belongs to the CarA family
M8961_RS04470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8961_RS04475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8961_RS04490	COG2267	carboxylic ester hydrolase activity
M8961_RS04500	COG1744	ABC transporter substrate-binding protein PnrA-like
M8961_RS04515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8961_RS04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8961_RS04525	COG5504	Zn-dependent protease
M8961_RS04530	COG0444	Belongs to the ABC transporter superfamily
M8961_RS04535	COG4608	Belongs to the ABC transporter superfamily
M8961_RS04545	COG0601	transmembrane transport
M8961_RS04550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8961_RS04560	COG0180	Tryptophanyl-tRNA synthetase
M8961_RS04565	COG4166	transmembrane transport
M8961_RS04570	COG0601	transmembrane transport
M8961_RS04575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8961_RS04580	COG0444	Belongs to the ABC transporter superfamily
M8961_RS04585	COG4608	Belongs to the ABC transporter superfamily
M8961_RS04595	COG0456	acetyltransferase
M8961_RS04600	COG1393	Belongs to the ArsC family
M8961_RS04605	COG0861	Integral membrane protein TerC family
M8961_RS04615	COG4862	establishment of competence for transformation
M8961_RS04620	COG4469	Competence protein
M8961_RS04625	COG1164	Oligoendopeptidase f
M8961_RS04635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8961_RS04640	COG2346	COG2346, Truncated hemoglobins
M8961_RS04645	COG0741	lytic transglycosylase activity
M8961_RS04650	COG4116	CYTH
M8961_RS04660	COG2357	RelA SpoT domain protein
M8961_RS04665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8961_RS04670	COG0564	pseudouridine synthase activity
M8961_RS04680	COG0475	glutathione-regulated potassium exporter activity
M8961_RS04680	COG0569	domain protein
M8961_RS04685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M8961_RS04690	COG0352	thiamine-phosphate diphosphorylase activity
M8961_RS04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8961_RS04700	COG2104	thiamine diphosphate biosynthetic process
M8961_RS04710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8961_RS04715	COG0351	phosphomethylpyrimidine kinase
M8961_RS04720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M8961_RS04775	COG0210	DNA helicase
M8961_RS04795	COG1131	(ABC) transporter
M8961_RS04805	COG2153	protein acetylation
M8961_RS04815	COG2382	esterase
M8961_RS04820	COG0626	cystathionine gamma-synthase activity
M8961_RS04825	COG0626	cystathionine gamma-synthase activity
M8961_RS04845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M8961_RS04850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8961_RS04855	COG1396	sequence-specific DNA binding
M8961_RS04860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M8961_RS04865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M8961_RS04870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M8961_RS04875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8961_RS04880	COG0512	Glutamine amidotransferase of anthranilate synthase
M8961_RS04885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8961_RS04890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8961_RS04895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8961_RS04910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M8961_RS04915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M8961_RS04920	COG0037	tRNA processing
M8961_RS04925	COG0515	serine threonine protein kinase
M8961_RS04930	COG2304	oxidoreductase activity
M8961_RS04935	COG2208	phosphoserine phosphatase activity
M8961_RS04950	COG1098	S1 RNA binding domain
M8961_RS04955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M8961_RS04970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M8961_RS04975	COG3956	TIGRFAM MazG family protein
M8961_RS04980	COG2244	polysaccharide biosynthetic process
M8961_RS04985	COG2002	toxin-antitoxin pair type II binding
M8961_RS04990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M8961_RS05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M8961_RS05025	COG0251	oxidation-reduction process
M8961_RS05030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8961_RS05045	COG4466	Protein conserved in bacteria
M8961_RS05055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M8961_RS05060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8961_RS05065	COG3583	domain protein
M8961_RS05065	COG3584	3D domain protein
M8961_RS05070	COG0084	hydrolase, TatD family'
M8961_RS05075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8961_RS05075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8961_RS05080	COG2002	toxin-antitoxin pair type II binding
M8961_RS05085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M8961_RS05095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M8961_RS05105	COG1774	PSP1 C-terminal conserved region
M8961_RS05110	COG0470	DNA polymerase III
M8961_RS05115	COG1728	Protein conserved in bacteria
M8961_RS05120	COG3870	Protein conserved in bacteria
M8961_RS05130	COG1982	Orn Lys Arg decarboxylase major
M8961_RS05135	COG3853	Toxic anion resistance protein (TelA)
M8961_RS05140	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M8961_RS05160	COG0640	Transcriptional regulator
M8961_RS05180	COG1725	Transcriptional regulator
M8961_RS05185	COG1131	(ABC) transporter
M8961_RS05205	COG1136	(ABC) transporter
M8961_RS05210	COG0577	efflux transmembrane transporter activity
M8961_RS05215	COG0745	RESPONSE REGULATOR receiver
M8961_RS05220	COG2205	protein histidine kinase activity
M8961_RS05225	COG1136	(ABC) transporter
M8961_RS05230	COG0577	efflux transmembrane transporter activity
M8961_RS05235	COG5522	Integral membrane protein (intg_mem_TP0381)
M8961_RS05240	COG2814	Major facilitator Superfamily
M8961_RS05245	COG2202	Pas domain
M8961_RS05245	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS05260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8961_RS05270	COG1486	melibiose metabolic process
M8961_RS05275	COG0395	ABC-type sugar transport system, permease component
M8961_RS05280	COG1175	transmembrane transport
M8961_RS05285	COG1653	transport
M8961_RS05290	COG1609	Transcriptional regulator
M8961_RS05300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M8961_RS05305	COG2081	HI0933 family
M8961_RS05310	COG2244	polysaccharide biosynthetic process
M8961_RS05315	COG1187	pseudouridine synthase activity
M8961_RS05320	COG1349	DNA-binding transcription factor activity
M8961_RS05325	COG1131	(ABC) transporter
M8961_RS05330	COG4473	ABC transporter
M8961_RS05335	COG2252	PERMEase
M8961_RS05340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8961_RS05345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8961_RS05350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M8961_RS05360	COG1597	lipid kinase activity
M8961_RS05365	COG0510	thiamine kinase activity
M8961_RS05380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS05385	COG0281	malic enzyme
M8961_RS05390	COG5584	Small secreted protein
M8961_RS05395	COG1363	Peptidase, m42
M8961_RS05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS05415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8961_RS05420	COG1674	ftsk spoiiie
M8961_RS05430	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8961_RS05435	COG4980	gas vesicle protein
M8961_RS05440	COG3118	belongs to the thioredoxin family
M8961_RS05445	COG1605	Chorismate mutase
M8961_RS05445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M8961_RS05450	COG1609	Transcriptional regulator
M8961_RS05455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M8961_RS05460	COG1360	Flagellar Motor Protein
M8961_RS05465	COG0123	including yeast histone deacetylase and acetoin utilization protein
M8961_RS05470	COG0517	IMP dehydrogenase activity
M8961_RS05475	COG0454	-acetyltransferase
M8961_RS05480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8961_RS05500	COG1378	Sugar-specific transcriptional regulator TrmB
M8961_RS05505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8961_RS05520	COG0693	protein deglycase activity
M8961_RS05530	COG1017	nitric oxide dioxygenase activity
M8961_RS05530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8961_RS05555	COG1595	DNA-templated transcription, initiation
M8961_RS05575	COG4282	regulation of fungal-type cell wall biogenesis
M8961_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS05590	COG2203	Gaf domain
M8961_RS05590	COG2199	diguanylate cyclase activity
M8961_RS05595	COG1956	GAF domain-containing protein
M8961_RS05600	COG1309	transcriptional regulator
M8961_RS05605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8961_RS05615	COG1114	Component of the transport system for branched-chain amino acids
M8961_RS05620	COG1104	cysteine desulfurase activity
M8961_RS05635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8961_RS05640	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M8961_RS05645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8961_RS05650	COG0616	signal peptide processing
M8961_RS05655	COG1714	RDD family
M8961_RS05665	COG3874	Sporulation protein YtfJ
M8961_RS05670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M8961_RS05675	COG0827	DNA restriction-modification system
M8961_RS05685	COG0521	Mo-molybdopterin cofactor biosynthetic process
M8961_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS05710	COG4109	DRTGG domain
M8961_RS05720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M8961_RS05740	COG0587	DNA-directed DNA polymerase activity
M8961_RS05745	COG0281	malic enzyme
M8961_RS05765	COG0469	pyruvate kinase activity
M8961_RS05770	COG3030	protein affecting phage T7 exclusion by the F plasmid
M8961_RS05775	COG0628	permease
M8961_RS05790	COG0372	Belongs to the citrate synthase family
M8961_RS05795	COG0538	isocitrate dehydrogenase activity
M8961_RS05805	COG0745	RESPONSE REGULATOR receiver
M8961_RS05810	COG5002	protein histidine kinase activity
M8961_RS05815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8961_RS05815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8961_RS05820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M8961_RS05825	COG1971	Probably functions as a manganese efflux pump
M8961_RS05830	COG0237	dephospho-CoA kinase activity
M8961_RS05835	COG0656	L-ascorbic acid biosynthetic process
M8961_RS05840	COG2814	Major facilitator Superfamily
M8961_RS05845	COG1733	regulation of RNA biosynthetic process
M8961_RS05850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8961_RS05865	COG3611	Membrane attachment protein
M8961_RS05870	COG1484	DNA-dependent DNA replication
M8961_RS05875	COG0398	Pfam SNARE associated Golgi protein
M8961_RS05890	COG1011	Hydrolase
M8961_RS05895	COG3275	phosphorelay sensor kinase activity
M8961_RS05900	COG3279	Response regulator of the LytR AlgR family
M8961_RS05905	COG1380	Effector of murein hydrolase LrgA
M8961_RS05910	COG1346	cytolysis
M8961_RS05915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M8961_RS05930	COG3326	Membrane
M8961_RS05940	COG1363	Peptidase, m42
M8961_RS05945	COG3507	Belongs to the glycosyl hydrolase 43 family
M8961_RS05950	COG2160	L-arabinose isomerase activity
M8961_RS05955	COG1069	ribulokinase activity
M8961_RS05960	COG0235	Class ii aldolase
M8961_RS05965	COG0647	UMP catabolic process
M8961_RS05975	COG1653	transport
M8961_RS05980	COG1175	transmembrane transport
M8961_RS05985	COG0395	ABC-type sugar transport system, permease component
M8961_RS05990	COG3534	alpha-L-arabinofuranosidase
M8961_RS05995	COG1966	Carbon starvation protein
M8961_RS06000	COG0247	lactate metabolic process
M8961_RS06005	COG0277	FAD linked oxidase domain protein
M8961_RS06010	COG3835	regulator
M8961_RS06020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8961_RS06025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M8961_RS06030	COG0072	phenylalanine-tRNA ligase activity
M8961_RS06030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8961_RS06045	COG1286	toxin biosynthetic process
M8961_RS06050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8961_RS06050	COG1796	DNA polymerase
M8961_RS06060	COG3766	membrane
M8961_RS06070	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS06075	COG1309	transcriptional regulator
M8961_RS06080	COG1024	Enoyl-CoA hydratase
M8961_RS06085	COG2086	electron transfer activity
M8961_RS06090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M8961_RS06095	COG3534	alpha-L-arabinofuranosidase
M8961_RS06100	COG3118	belongs to the thioredoxin family
M8961_RS06110	COG0527	aspartate kinase activity
M8961_RS06115	COG1719	4-vinyl reductase, 4VR
M8961_RS06120	COG2009	succinate dehydrogenase
M8961_RS06125	COG1053	succinate dehydrogenase
M8961_RS06130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M8961_RS06135	COG0824	Thioesterase
M8961_RS06140	COG2197	response regulator
M8961_RS06145	COG1846	Transcriptional regulator
M8961_RS06155	COG5401	PFAM Sporulation and spore germination
M8961_RS06165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M8961_RS06170	COG0622	Phosphoesterase
M8961_RS06195	COG0028	Belongs to the TPP enzyme family
M8961_RS06200	COG0440	acetolactate synthase activity
M8961_RS06215	COG0473	3-isopropylmalate dehydrogenase activity
M8961_RS06230	COG0457	Tetratricopeptide repeat
M8961_RS06230	COG1477	protein flavinylation
M8961_RS06245	COG0470	DNA polymerase III
M8961_RS06245	COG1067	ATP-dependent peptidase activity
M8961_RS06250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M8961_RS06270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8961_RS06280	COG1587	Uroporphyrinogen-III synthase
M8961_RS06285	COG0113	porphobilinogen synthase activity
M8961_RS06295	COG1388	LysM domain
M8961_RS06300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8961_RS06310	COG0525	valine-tRNA ligase activity
M8961_RS06315	COG0285	dihydrofolate synthase activity
M8961_RS06320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M8961_RS06340	COG1077	Cell shape determining protein MreB Mrl
M8961_RS06350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M8961_RS06360	COG2894	cell division
M8961_RS06365	COG0739	heme binding
M8961_RS06370	COG1994	Peptidase M50
M8961_RS06380	COG2868	ribosomal protein
M8961_RS06390	COG3290	protein histidine kinase activity
M8961_RS06405	COG0077	Prephenate dehydratase
M8961_RS06410	COG1827	regulation of RNA biosynthetic process
M8961_RS06415	COG1104	cysteine desulfurase activity
M8961_RS06420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M8961_RS06425	COG0157	Belongs to the NadC ModD family
M8961_RS06435	COG1388	LysM domain
M8961_RS06475	COG1862	Preprotein translocase
M8961_RS06485	COG2323	membrane
M8961_RS06490	COG2244	polysaccharide biosynthetic process
M8961_RS06500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8961_RS06500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8961_RS06505	COG0490	domain, Protein
M8961_RS06510	COG5416	Lipopolysaccharide assembly protein A domain
M8961_RS06515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M8961_RS06515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M8961_RS06525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M8961_RS06535	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS06535	COG3103	Sh3 type 3 domain protein
M8961_RS06535	COG4991	sh3 domain protein
M8961_RS06560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M8961_RS06565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8961_RS06570	COG1959	2 iron, 2 sulfur cluster binding
M8961_RS06575	COG1104	cysteine desulfurase activity
M8961_RS06585	COG0457	Tetratricopeptide repeat
M8961_RS06590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M8961_RS06595	COG3881	PFAM PRC-barrel domain
M8961_RS06610	COG0765	amino acid transport
M8961_RS06615	COG0765	amino acid transport
M8961_RS06620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8961_RS06625	COG1126	abc transporter atp-binding protein
M8961_RS06630	COG0628	permease
M8961_RS06655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8961_RS06660	COG4122	O-methyltransferase activity
M8961_RS06665	COG0826	peptidase U32
M8961_RS06670	COG0826	peptidase U32
M8961_RS06685	COG0768	penicillin binding
M8961_RS06710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8961_RS06715	COG0626	cystathionine gamma-synthase activity
M8961_RS06725	COG2427	Protein of unknown function (DUF1641)
M8961_RS06730	COG3383	formate dehydrogenase (NAD+) activity
M8961_RS06735	COG5609	conserved protein (DUF2294)
M8961_RS06740	COG2116	formate transmembrane transporter activity
M8961_RS06755	COG2226	methyltransferase
M8961_RS06760	COG1309	transcriptional regulator
M8961_RS06765	COG2124	cytochrome p450
M8961_RS06765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8961_RS06770	COG2814	Major facilitator Superfamily
M8961_RS06775	COG0583	DNA-binding transcription factor activity
M8961_RS06780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M8961_RS06790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS06790	COG3711	transcriptional antiterminator
M8961_RS06795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8961_RS06795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8961_RS06795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS06800	COG1482	cell wall glycoprotein biosynthetic process
M8961_RS06810	COG0561	phosphatase activity
M8961_RS06815	COG0561	phosphatase activity
M8961_RS06825	COG2318	DinB family
M8961_RS06840	COG0563	adenylate kinase activity
M8961_RS06845	COG0454	-acetyltransferase
M8961_RS06850	COG2311	Membrane
M8961_RS06855	COG0745	RESPONSE REGULATOR receiver
M8961_RS06860	COG0642	Histidine kinase
M8961_RS06860	COG5002	protein histidine kinase activity
M8961_RS06895	COG0398	Pfam SNARE associated Golgi protein
M8961_RS06905	COG2755	lipolytic protein G-D-S-L family
M8961_RS06915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M8961_RS06920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8961_RS06925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M8961_RS06930	COG1534	Rna-binding protein
M8961_RS06940	COG1713	HD superfamily hydrolase involved in NAD metabolism
M8961_RS06945	COG0799	negative regulation of ribosome biogenesis
M8961_RS06950	COG2226	methyltransferase
M8961_RS06955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8961_RS06960	COG1555	photosystem II stabilization
M8961_RS06960	COG1596	polysaccharide export
M8961_RS06965	COG2131	deaminase
M8961_RS06970	COG2333	competence protein COMEC
M8961_RS06970	COG0658	competence protein
M8961_RS07000	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS07015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8961_RS07045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M8961_RS07050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8961_RS07055	COG1283	sodium-dependent phosphate transmembrane transporter activity
M8961_RS07065	COG1610	YqeY-like protein
M8961_RS07070	COG1030	water channel activity
M8961_RS07075	COG4864	UPF0365 protein
M8961_RS07090	COG0561	phosphatase activity
M8961_RS07095	COG1702	phosphate starvation-inducible protein PhoH
M8961_RS07100	COG1480	7TM receptor with intracellular HD hydrolase
M8961_RS07110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M8961_RS07115	COG0295	cytidine deaminase activity
M8961_RS07120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M8961_RS07140	COG0751	glycine-tRNA ligase activity
M8961_RS07145	COG0517	IMP dehydrogenase activity
M8961_RS07160	COG0358	DNA primase activity
M8961_RS07165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M8961_RS07170	COG2010	Cytochrome c
M8961_RS07175	COG2384	SAM-dependent methyltransferase
M8961_RS07180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M8961_RS07195	COG0513	Belongs to the DEAD box helicase family
M8961_RS07210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS07215	COG0735	belongs to the Fur family
M8961_RS07220	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M8961_RS07225	COG4709	membrane
M8961_RS07235	COG1388	LysM domain
M8961_RS07240	COG5521	maltodextrose utilization protein MalA
M8961_RS07245	COG2839	Protein conserved in bacteria
M8961_RS07250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8961_RS07255	COG0477	Major facilitator Superfamily
M8961_RS07260	COG0768	penicillin binding
M8961_RS07290	COG3290	protein histidine kinase activity
M8961_RS07295	COG4565	transcriptional regulatory protein
M8961_RS07300	COG3181	Tripartite tricarboxylate transporter family receptor
M8961_RS07305	COG2851	Citrate transporter
M8961_RS07310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS07315	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M8961_RS07325	COG2258	MOSC domain
M8961_RS07345	COG0024	Methionine aminopeptidase
M8961_RS07350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS07350	COG1263	PTS System
M8961_RS07360	COG1368	sulfuric ester hydrolase activity
M8961_RS07370	COG0071	Belongs to the small heat shock protein (HSP20) family
M8961_RS07385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS07385	COG1263	PTS System
M8961_RS07390	COG0366	Alpha amylase catalytic
M8961_RS07395	COG2188	Transcriptional regulator
M8961_RS07400	COG0778	Nitroreductase
M8961_RS07415	COG0737	Belongs to the 5'-nucleotidase family
M8961_RS07420	COG0693	protein deglycase activity
M8961_RS07425	COG1609	Transcriptional regulator
M8961_RS07440	COG2814	Major facilitator Superfamily
M8961_RS07450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8961_RS07455	COG4980	gas vesicle protein
M8961_RS07460	COG1295	ribonuclease BN
M8961_RS07465	COG0477	Major facilitator Superfamily
M8961_RS07470	COG0387	Pfam Sodium calcium exchanger
M8961_RS07480	COG0668	transmembrane transport
M8961_RS07485	COG0535	radical SAM domain protein
M8961_RS07495	COG0726	polysaccharide deacetylase
M8961_RS07500	COG2084	Dehydrogenase
M8961_RS07510	COG0598	Magnesium transport protein CorA
M8961_RS07515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M8961_RS07520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8961_RS07530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8961_RS07535	COG4637	Psort location Cytoplasmic, score
M8961_RS07540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8961_RS07545	COG0022	dehydrogenase e1 component
M8961_RS07550	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8961_RS07555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8961_RS07560	COG3284	Transcriptional regulator
M8961_RS07570	COG1486	melibiose metabolic process
M8961_RS07575	COG1737	Transcriptional regulator
M8961_RS07580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS07580	COG1263	PTS System
M8961_RS07585	COG5434	Belongs to the glycosyl hydrolase 28 family
M8961_RS07590	COG1132	(ABC) transporter
M8961_RS07595	COG1132	(ABC) transporter
M8961_RS07600	COG2259	Doxx family
M8961_RS07605	COG2514	catechol 2,3-dioxygenase activity
M8961_RS07615	COG1695	Transcriptional regulator
M8961_RS07620	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8961_RS07625	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M8961_RS07630	COG0574	Belongs to the PEP-utilizing enzyme family
M8961_RS07630	COG3848	Pyruvate phosphate dikinase
M8961_RS07635	COG2732	(Barnase) inhibitor
M8961_RS07640	COG2318	DinB family
M8961_RS07645	COG2814	Major facilitator Superfamily
M8961_RS07650	COG1846	Transcriptional regulator
M8961_RS07655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M8961_RS07655	COG0392	lysyltransferase activity
M8961_RS07660	COG0384	phenazine biosynthesis protein PhzF
M8961_RS07665	COG0778	Nitroreductase
M8961_RS07680	COG1090	epimerase
M8961_RS07695	COG2814	Major facilitator Superfamily
M8961_RS07705	COG3591	Belongs to the peptidase S1B family
M8961_RS07720	COG3103	Sh3 type 3 domain protein
M8961_RS07725	COG5658	integral membrane protein
M8961_RS07730	COG0596	Alpha beta hydrolase
M8961_RS07735	COG0463	Glycosyl transferase, family 2
M8961_RS07740	COG4485	Bacterial membrane protein, YfhO
M8961_RS07745	COG1988	membrane-bound metal-dependent
M8961_RS07750	COG1194	a g-specific adenine glycosylase
M8961_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS07780	COG1132	(ABC) transporter
M8961_RS07785	COG4129	membrane
M8961_RS07795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M8961_RS07800	COG0735	belongs to the Fur family
M8961_RS07825	COG2814	Major facilitator Superfamily
M8961_RS07830	COG0604	alcohol dehydrogenase
M8961_RS07835	COG3832	glyoxalase III activity
M8961_RS07845	COG0531	amino acid
M8961_RS07850	COG1309	transcriptional regulator
M8961_RS07855	COG2076	Multidrug Resistance protein
M8961_RS07860	COG2076	Multidrug Resistance protein
M8961_RS07865	COG2807	transmembrane transport
M8961_RS07870	COG2186	Transcriptional regulator
M8961_RS07875	COG2188	Transcriptional regulator
M8961_RS07880	COG2814	Major facilitator Superfamily
M8961_RS07885	COG1388	LysM domain
M8961_RS07895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8961_RS07910	COG1819	glycosyl
M8961_RS07915	COG1802	Transcriptional regulator
M8961_RS07925	COG2226	methyltransferase
M8961_RS07930	COG1051	belongs to the nudix hydrolase family
M8961_RS07935	COG0697	spore germination
M8961_RS07940	COG0789	Transcriptional regulator
M8961_RS07940	COG4978	Transcriptional regulator
M8961_RS07945	COG0456	acetyltransferase
M8961_RS07950	COG0730	response to heat
M8961_RS07960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M8961_RS07965	COG2814	Major facilitator Superfamily
M8961_RS07975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS07980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8961_RS07985	COG0488	(ABC) transporter
M8961_RS07990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M8961_RS07995	COG2409	Drug exporters of the RND superfamily
M8961_RS08000	COG2197	response regulator
M8961_RS08005	COG4585	Histidine kinase
M8961_RS08015	COG5577	PFAM Coat F domain
M8961_RS08020	COG1063	alcohol dehydrogenase
M8961_RS08030	COG5577	PFAM Coat F domain
M8961_RS08035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8961_RS08040	COG0697	spore germination
M8961_RS08045	COG1309	transcriptional regulator
M8961_RS08050	COG2814	Major facilitator Superfamily
M8961_RS08080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8961_RS08090	COG0789	Transcriptional regulator
M8961_RS08095	COG1064	alcohol dehydrogenase
M8961_RS08110	COG0351	phosphomethylpyrimidine kinase
M8961_RS08145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M8961_RS08150	COG2318	DinB family
M8961_RS08160	COG0662	Cupin 2, conserved barrel domain protein
M8961_RS08185	COG0277	FAD linked oxidase domain protein
M8961_RS08200	COG0662	Cupin 2, conserved barrel domain protein
M8961_RS08210	COG3621	Patatin-like phospholipase
M8961_RS08215	COG2271	Major facilitator Superfamily
M8961_RS08220	COG0456	acetyltransferase
M8961_RS08220	COG1846	Transcriptional regulator
M8961_RS08235	COG1794	racemase activity, acting on amino acids and derivatives
M8961_RS08240	COG0730	response to heat
M8961_RS08245	COG0425	Belongs to the sulfur carrier protein TusA family
M8961_RS08255	COG0425	Belongs to the sulfur carrier protein TusA family
M8961_RS08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8961_RS08265	COG2210	Belongs to the sulfur carrier protein TusA family
M8961_RS08270	COG1937	Protein conserved in bacteria
M8961_RS08275	COG1329	Transcriptional regulator
M8961_RS08280	COG1278	Cold shock
M8961_RS08285	COG3239	Fatty acid desaturase
M8961_RS08295	COG0604	alcohol dehydrogenase
M8961_RS08305	COG0300	oxidoreductase activity
M8961_RS08310	COG1309	transcriptional regulator
M8961_RS08315	COG2910	NAD(P)H-binding
M8961_RS08320	COG1959	2 iron, 2 sulfur cluster binding
M8961_RS08335	COG2030	dehydratase
M8961_RS08350	COG0477	Major facilitator Superfamily
M8961_RS08370	COG1522	sequence-specific DNA binding
M8961_RS08375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M8961_RS08385	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8961_RS08440	COG2183	response to ionizing radiation
M8961_RS08445	COG2208	phosphoserine phosphatase activity
M8961_RS08450	COG1191	sigma factor activity
M8961_RS08460	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS08465	COG2208	phosphoserine phosphatase activity
M8961_RS08470	COG2172	sigma factor antagonist activity
M8961_RS08475	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS08480	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS08485	COG2337	Toxic component of a toxin-antitoxin (TA) module
M8961_RS08490	COG0864	Transcriptional regulator
M8961_RS08495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8961_RS08500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M8961_RS08510	COG0705	Rhomboid family
M8961_RS08515	COG3428	Bacterial PH domain
M8961_RS08520	COG3402	PFAM membrane-flanked domain
M8961_RS08525	COG0513	Belongs to the DEAD box helicase family
M8961_RS08530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M8961_RS08540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS08560	COG1960	acyl-CoA dehydrogenase activity
M8961_RS08570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8961_RS08575	COG1131	(ABC) transporter
M8961_RS08580	COG0628	permease
M8961_RS08585	COG1301	dicarboxylic acid transport
M8961_RS08590	COG4565	transcriptional regulatory protein
M8961_RS08595	COG3290	protein histidine kinase activity
M8961_RS08600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M8961_RS08605	COG3546	catalase activity
M8961_RS08610	COG2329	Antibiotic biosynthesis monooxygenase
M8961_RS08615	COG0662	Cupin 2, conserved barrel domain protein
M8961_RS08625	COG2217	Heavy metal translocating P-type atpase
M8961_RS08630	COG2076	Multidrug Resistance protein
M8961_RS08650	COG1914	H( )-stimulated, divalent metal cation uptake system
M8961_RS08675	COG0457	Tetratricopeptide repeat
M8961_RS08705	COG0028	Belongs to the TPP enzyme family
M8961_RS08710	COG0494	nUDIX hydrolase
M8961_RS08715	COG0531	amino acid
M8961_RS08725	COG1215	transferase activity, transferring glycosyl groups
M8961_RS08730	COG5298	Protein conserved in bacteria
M8961_RS08735	COG3706	GGDEF domain
M8961_RS08740	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M8961_RS08745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8961_RS08745	COG0551	DNA topoisomerase type I activity
M8961_RS08750	COG1522	sequence-specific DNA binding
M8961_RS08755	COG2814	Major facilitator Superfamily
M8961_RS08765	COG3871	stress protein (general stress protein 26)
M8961_RS08770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8961_RS08775	COG1917	Cupin 2, conserved barrel domain protein
M8961_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS08785	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS08790	COG3711	transcriptional antiterminator
M8961_RS08795	COG4989	oxidoreductase activity
M8961_RS08800	COG0768	penicillin binding
M8961_RS08805	COG2329	Antibiotic biosynthesis monooxygenase
M8961_RS08815	COG2755	lipolytic protein G-D-S-L family
M8961_RS08820	COG1414	Transcriptional regulator
M8961_RS08825	COG1984	allophanate hydrolase subunit 2
M8961_RS08830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8961_RS08840	COG1914	H( )-stimulated, divalent metal cation uptake system
M8961_RS08850	COG0561	phosphatase activity
M8961_RS08860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M8961_RS08870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS08875	COG2213	PTS system mannitol-specific
M8961_RS08885	COG1349	DNA-binding transcription factor activity
M8961_RS08890	COG1276	copper resistance
M8961_RS08890	COG2372	response to copper ion
M8961_RS08895	COG4549	nuclear export factor GLE1
M8961_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS08905	COG4975	Glucose uptake
M8961_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS08915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8961_RS08920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8961_RS08925	COG0640	Transcriptional regulator
M8961_RS08930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M8961_RS08935	COG0778	Nitroreductase
M8961_RS08940	COG1309	transcriptional regulator
M8961_RS08945	COG2814	Major facilitator Superfamily
M8961_RS08950	COG4607	ABC-type enterochelin transport system periplasmic component
M8961_RS08955	COG4604	ABC transporter, ATP-binding protein
M8961_RS08960	COG4605	iron ion homeostasis
M8961_RS08965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS08970	COG0527	aspartate kinase activity
M8961_RS08985	COG0457	Tetratricopeptide repeat
M8961_RS08990	COG5002	protein histidine kinase activity
M8961_RS08990	COG3850	Histidine kinase
M8961_RS08995	COG0745	RESPONSE REGULATOR receiver
M8961_RS09000	COG0577	efflux transmembrane transporter activity
M8961_RS09005	COG1136	(ABC) transporter
M8961_RS09010	COG2079	MmgE PrpD family protein
M8961_RS09015	COG1473	amidohydrolase
M8961_RS09020	COG1126	abc transporter atp-binding protein
M8961_RS09025	COG0765	amino acid transport
M8961_RS09030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8961_RS09035	COG0456	acetyltransferase
M8961_RS09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS09045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8961_RS09055	COG0697	spore germination
M8961_RS09065	COG5434	Belongs to the glycosyl hydrolase 28 family
M8961_RS09070	COG3104	oligopeptide transport
M8961_RS09085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M8961_RS09090	COG0163	prenyltransferase activity
M8961_RS09095	COG0583	DNA-binding transcription factor activity
M8961_RS09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8961_RS09105	COG0765	amino acid transport
M8961_RS09110	COG1126	abc transporter atp-binding protein
M8961_RS09115	COG2364	Membrane
M8961_RS09125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8961_RS09130	COG0697	spore germination
M8961_RS09145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M8961_RS09150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS09165	COG5294	Protein conserved in bacteria
M8961_RS09170	COG0577	efflux transmembrane transporter activity
M8961_RS09175	COG1136	(ABC) transporter
M8961_RS09180	COG2205	protein histidine kinase activity
M8961_RS09185	COG0745	RESPONSE REGULATOR receiver
M8961_RS09190	COG2205	protein histidine kinase activity
M8961_RS09195	COG0745	RESPONSE REGULATOR receiver
M8961_RS09225	COG1082	Xylose isomerase domain protein TIM barrel
M8961_RS09235	COG2814	Major facilitator Superfamily
M8961_RS09265	COG1349	DNA-binding transcription factor activity
M8961_RS09270	COG0667	Aldo Keto reductase
M8961_RS09275	COG2814	Major facilitator Superfamily
M8961_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS09295	COG2197	response regulator
M8961_RS09300	COG4585	Histidine kinase
M8961_RS09305	COG3239	Fatty acid desaturase
M8961_RS09310	COG1309	transcriptional regulator
M8961_RS09315	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS09320	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M8961_RS09330	COG0640	Transcriptional regulator
M8961_RS09335	COG2814	Major facilitator Superfamily
M8961_RS09340	COG1714	RDD family
M8961_RS09350	COG0450	alkyl hydroperoxide reductase
M8961_RS09355	COG3634	alkyl hydroperoxide reductase activity
M8961_RS09360	COG3177	Filamentation induced by cAMP protein fic
M8961_RS09365	COG1113	amino acid transport
M8961_RS09375	COG2080	2 iron, 2 sulfur cluster binding
M8961_RS09390	COG2068	MobA-Related Protein
M8961_RS09395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M8961_RS09460	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M8961_RS09465	COG0667	Aldo Keto reductase
M8961_RS09470	COG0456	acetyltransferase
M8961_RS09475	COG0457	Tetratricopeptide repeat
M8961_RS09480	COG0010	Belongs to the arginase family
M8961_RS09485	COG0833	amino acid
M8961_RS09490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8961_RS09495	COG3829	transcription factor binding
M8961_RS09505	COG0488	(ABC) transporter
M8961_RS09520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8961_RS09525	COG5002	protein histidine kinase activity
M8961_RS09525	COG3850	Histidine kinase
M8961_RS09530	COG0745	RESPONSE REGULATOR receiver
M8961_RS09535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8961_RS09540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M8961_RS09545	COG4853	Protein conserved in bacteria
M8961_RS09550	COG4863	YycH protein
M8961_RS09555	COG5002	protein histidine kinase activity
M8961_RS09560	COG0745	RESPONSE REGULATOR receiver
M8961_RS09590	COG0346	lactoylglutathione lyase activity
M8961_RS09595	COG0305	Participates in initiation and elongation during chromosome replication
M8961_RS09610	COG3093	addiction module antidote protein HigA
M8961_RS09615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M8961_RS09630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M8961_RS09635	COG0438	transferase activity, transferring glycosyl groups
M8961_RS09655	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M8961_RS09660	COG4241	membrane
M8961_RS09670	COG5577	PFAM Coat F domain
M8961_RS09675	COG1733	regulation of RNA biosynthetic process
M8961_RS09685	COG0697	spore germination
M8961_RS09690	COG1621	beta-fructofuranosidase activity
M8961_RS09695	COG1621	beta-fructofuranosidase activity
M8961_RS09700	COG1802	Transcriptional regulator
M8961_RS09705	COG2318	DinB family
M8961_RS09715	COG0583	DNA-binding transcription factor activity
M8961_RS09725	COG2814	Major facilitator Superfamily
M8961_RS09730	COG0583	DNA-binding transcription factor activity
M8961_RS09740	COG0778	Nitroreductase
M8961_RS09745	COG1846	Transcriptional regulator
M8961_RS09750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS09755	COG1846	Transcriptional regulator
M8961_RS09760	COG2153	protein acetylation
M8961_RS09770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8961_RS09775	COG0583	DNA-binding transcription factor activity
M8961_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS09790	COG1331	Highly conserved protein containing a thioredoxin domain
M8961_RS09805	COG0457	Tetratricopeptide repeat
M8961_RS09810	COG0515	serine threonine protein kinase
M8961_RS09810	COG2815	serine threonine protein kinase
M8961_RS09815	COG1331	Highly conserved protein containing a thioredoxin domain
M8961_RS09820	COG1266	CAAX protease self-immunity
M8961_RS09825	COG0477	Major facilitator Superfamily
M8961_RS09825	COG2814	Major facilitator Superfamily
M8961_RS09830	COG0346	lactoylglutathione lyase activity
M8961_RS09835	COG1609	Transcriptional regulator
M8961_RS09840	COG0708	Exodeoxyribonuclease III
M8961_RS09845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8961_RS09850	COG2169	Transcriptional regulator
M8961_RS09860	COG0629	single-stranded DNA binding
M8961_RS09870	COG0012	GTP binding
M8961_RS09875	COG0243	molybdopterin cofactor binding
M8961_RS09880	COG4481	Protein conserved in bacteria
M8961_RS09885	COG3949	Membrane
M8961_RS09900	COG1475	DNA binding
M8961_RS09905	COG1192	Involved in chromosome partitioning
M8961_RS09930	COG1847	R3H domain protein
M8961_RS09935	COG0706	membrane insertase activity
M8961_RS09955	COG0592	DNA-directed DNA polymerase activity
M8961_RS09960	COG2501	S4 domain
M8961_RS09975	COG0187	DNA topoisomerase II activity
M8961_RS09980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8961_RS10000	COG2027	D-alanyl-D-alanine carboxypeptidase
M8961_RS10005	COG2017	converts alpha-aldose to the beta-anomer
M8961_RS10010	COG0534	Mate efflux family protein
M8961_RS10025	COG0582	viral genome integration into host DNA
M8961_RS10030	COG0166	Belongs to the GPI family
M8961_RS10035	COG0405	Gamma-glutamyltransferase
M8961_RS10040	COG2814	Major facilitator Superfamily
M8961_RS10045	COG0640	Transcriptional regulator
M8961_RS10050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M8961_RS10060	COG0604	alcohol dehydrogenase
M8961_RS10070	COG0493	'glutamate synthase
M8961_RS10075	COG0070	glutamate synthase
M8961_RS10075	COG0067	glutamate synthase
M8961_RS10075	COG0069	glutamate synthase activity
M8961_RS10080	COG0583	DNA-binding transcription factor activity
M8961_RS10085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M8961_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS10120	COG0300	oxidoreductase activity
M8961_RS10125	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8961_RS10135	COG2814	Major facilitator Superfamily
M8961_RS10140	COG1070	Carbohydrate kinase
M8961_RS10145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8961_RS10150	COG0243	molybdopterin cofactor binding
M8961_RS10180	COG5444	nuclease activity
M8961_RS10185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8961_RS10190	COG2207	Transcriptional regulator
M8961_RS10190	COG0662	Cupin 2, conserved barrel domain protein
M8961_RS10195	COG1309	transcriptional regulator
M8961_RS10200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS10210	COG0640	Transcriptional regulator
M8961_RS10215	COG0741	lytic transglycosylase activity
M8961_RS10220	COG2322	membrane
M8961_RS10235	COG1619	proteins homologs of microcin C7 resistance protein MccF
M8961_RS10245	COG3584	3D domain protein
M8961_RS10245	COG1388	LysM domain
M8961_RS10250	COG0514	ATP-dependent DNA helicase (RecQ)
M8961_RS10260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M8961_RS10265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8961_RS10280	COG0071	Belongs to the small heat shock protein (HSP20) family
M8961_RS10310	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS10315	COG1657	PFAM Prenyltransferase squalene oxidase
M8961_RS10320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8961_RS10325	COG0733	neurotransmitter:sodium symporter activity
M8961_RS10330	COG0385	Bile acid
M8961_RS10335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS10340	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8961_RS10350	COG4548	von Willebrand factor, type A
M8961_RS10355	COG0714	Associated with various cellular activities
M8961_RS10360	COG2032	superoxide dismutase activity
M8961_RS10365	COG1388	LysM domain
M8961_RS10365	COG0791	NLP P60 protein
M8961_RS10370	COG1819	glycosyl
M8961_RS10375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8961_RS10380	COG0534	Mate efflux family protein
M8961_RS10385	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS10390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8961_RS10395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8961_RS10405	COG2962	Rard protein
M8961_RS10420	COG1942	4-Oxalocrotonate Tautomerase
M8961_RS10430	COG1733	regulation of RNA biosynthetic process
M8961_RS10435	COG0778	Nitroreductase
M8961_RS10440	COG0400	carboxylic ester hydrolase activity
M8961_RS10445	COG0346	lactoylglutathione lyase activity
M8961_RS10455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8961_RS10465	COG2723	6-phospho-beta-galactosidase activity
M8961_RS10470	COG2188	Transcriptional regulator
M8961_RS10475	COG0793	Belongs to the peptidase S41A family
M8961_RS10475	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS10480	COG2226	methyltransferase
M8961_RS10490	COG1876	peptidase activity
M8961_RS10510	COG0671	phosphoesterase, PA-phosphatase related
M8961_RS10545	COG1509	lysine 2,3-aminomutase activity
M8961_RS10550	COG0456	acetyltransferase
M8961_RS10555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8961_RS10560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M8961_RS10565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M8961_RS10570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8961_RS10585	COG0456	acetyltransferase
M8961_RS10590	COG0463	Glycosyl transferase, family 2
M8961_RS10605	COG4641	Protein conserved in bacteria
M8961_RS10615	COG1086	Polysaccharide biosynthesis protein
M8961_RS10640	COG1388	LysM domain
M8961_RS10645	COG0457	Tetratricopeptide repeat
M8961_RS10660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8961_RS10660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS10675	COG4585	Histidine kinase
M8961_RS10680	COG0730	response to heat
M8961_RS10730	COG1846	Transcriptional regulator
M8961_RS10735	COG4698	Protein conserved in bacteria
M8961_RS10740	COG2755	lipolytic protein G-D-S-L family
M8961_RS10745	COG1999	signal sequence binding
M8961_RS10755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8961_RS10760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M8961_RS10765	COG1272	protein, Hemolysin III
M8961_RS10770	COG0204	Acyl-transferase
M8961_RS10775	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8961_RS10790	COG2136	Putative SAM-dependent methyltransferase
M8961_RS10790	COG2521	methyltransferase
M8961_RS10805	COG1413	lyase activity
M8961_RS10810	COG1418	mRNA catabolic process
M8961_RS10815	COG0386	Belongs to the glutathione peroxidase family
M8961_RS10825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8961_RS10835	COG1278	Cold shock
M8961_RS10855	COG0328	RNA-DNA hybrid ribonuclease activity
M8961_RS10860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M8961_RS10865	COG0328	RNA-DNA hybrid ribonuclease activity
M8961_RS10875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8961_RS10890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8961_RS10900	COG1755	Isoprenylcysteine carboxyl methyltransferase
M8961_RS10905	COG3424	synthase
M8961_RS10925	COG2323	membrane
M8961_RS10930	COG1335	isochorismatase
M8961_RS10940	COG2233	PERMEase
M8961_RS10950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M8961_RS10955	COG1199	ATP-dependent helicase activity
M8961_RS10975	COG0116	Belongs to the methyltransferase superfamily
M8961_RS11005	COG3359	exonuclease
M8961_RS11010	COG1205	dead DEAH box helicase
M8961_RS11010	COG1111	helicase
M8961_RS11015	COG2190	(PTS) system
M8961_RS11020	COG0071	Belongs to the small heat shock protein (HSP20) family
M8961_RS11060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8961_RS11060	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8961_RS11070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8961_RS11075	COG3935	DnaD domain protein
M8961_RS11085	COG0436	Aminotransferase
M8961_RS11090	COG5353	protein conserved in bacteria
M8961_RS11100	COG1199	ATP-dependent helicase activity
M8961_RS11100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M8961_RS11130	COG0438	transferase activity, transferring glycosyl groups
M8961_RS11135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8961_RS11150	COG1694	Mazg nucleotide pyrophosphohydrolase
M8961_RS11155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS11160	COG2140	Oxalate decarboxylase
M8961_RS11170	COG4347	Protein of unknown function (DUF1405)
M8961_RS11175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8961_RS11175	COG2010	Cytochrome c
M8961_RS11180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M8961_RS11185	COG0723	plastoquinol--plastocyanin reductase activity
M8961_RS11200	COG0457	Tetratricopeptide repeat
M8961_RS11210	COG0287	Prephenate dehydrogenase
M8961_RS11245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8961_RS11250	COG4401	Chorismate mutase type I
M8961_RS11265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M8961_RS11270	COG0105	UTP biosynthetic process
M8961_RS11275	COG0142	geranyltranstransferase activity
M8961_RS11285	COG0142	geranyltranstransferase activity
M8961_RS11300	COG0776	regulation of translation
M8961_RS11305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8961_RS11345	COG0539	negative regulation of cytoplasmic translation
M8961_RS11365	COG2959	enzyme of heme biosynthesis
M8961_RS11370	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS11370	COG3773	Cell wall hydrolase
M8961_RS11375	COG2339	peptidase activity
M8961_RS11380	COG0492	ferredoxin-NADP+ reductase activity
M8961_RS11385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8961_RS11390	COG4862	establishment of competence for transformation
M8961_RS11395	COG1408	metallophosphoesterase
M8961_RS11405	COG1388	LysM domain
M8961_RS11410	COG1266	CAAX protease self-immunity
M8961_RS11415	COG0514	ATP-dependent DNA helicase (RecQ)
M8961_RS11420	COG4955	Helix-turn-helix domain
M8961_RS11425	COG1141	Ferredoxin
M8961_RS11430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M8961_RS11435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8961_RS11445	COG1595	DNA-templated transcription, initiation
M8961_RS11450	COG5002	protein histidine kinase activity
M8961_RS11455	COG0745	RESPONSE REGULATOR receiver
M8961_RS11460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M8961_RS11465	COG1333	cytochrome c biogenesis protein
M8961_RS11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS11475	COG1187	pseudouridine synthase activity
M8961_RS11480	COG0700	Nucleoside recognition
M8961_RS11485	COG2715	membrane protein required for spore maturation
M8961_RS11490	COG1686	Belongs to the peptidase S11 family
M8961_RS11515	COG1547	Domain of unknown function (DUF309)
M8961_RS11520	COG0456	acetyltransferase
M8961_RS11535	COG0307	riboflavin synthase, alpha
M8961_RS11540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8961_RS11540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8961_RS11550	COG0681	Belongs to the peptidase S26 family
M8961_RS11560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M8961_RS11565	COG4086	secreted protein
M8961_RS11570	COG0019	diaminopimelate decarboxylase activity
M8961_RS11575	COG0697	spore germination
M8961_RS11590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8961_RS11610	COG1191	sigma factor activity
M8961_RS11620	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS11625	COG1686	Belongs to the peptidase S11 family
M8961_RS11630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M8961_RS11635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M8961_RS11640	COG4974	Belongs to the 'phage' integrase family
M8961_RS11650	COG0735	belongs to the Fur family
M8961_RS11655	COG1300	Membrane
M8961_RS11670	COG0281	malic enzyme
M8961_RS11675	COG1757	Na H antiporter
M8961_RS11680	COG1027	Aspartate ammonia-lyase
M8961_RS11685	COG0252	asparaginase activity
M8961_RS11690	COG1396	sequence-specific DNA binding
M8961_RS11695	COG1379	DNA repair
M8961_RS11700	COG0494	nUDIX hydrolase
M8961_RS11710	COG0667	Aldo Keto reductase
M8961_RS11720	COG1073	alpha beta
M8961_RS11730	COG4918	Iron-sulphur cluster biosynthesis
M8961_RS11735	COG0456	acetyltransferase
M8961_RS11735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M8961_RS11740	COG2329	Antibiotic biosynthesis monooxygenase
M8961_RS11745	COG0456	acetyltransferase
M8961_RS11750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8961_RS11765	COG0628	permease
M8961_RS11775	COG0346	lactoylglutathione lyase activity
M8961_RS11785	COG3048	D-serine ammonia-lyase activity
M8961_RS11790	COG0300	oxidoreductase activity
M8961_RS11795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS11800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8961_RS11805	COG1024	Enoyl-CoA hydratase
M8961_RS11810	COG3425	synthase
M8961_RS11815	COG2124	cytochrome p450
M8961_RS11820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS11820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS11820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11820	COG3321	synthase
M8961_RS11825	COG3321	synthase
M8961_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS11825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS11830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11830	COG3321	synthase
M8961_RS11830	COG0300	oxidoreductase activity
M8961_RS11830	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS11835	COG3321	synthase
M8961_RS11835	COG0300	oxidoreductase activity
M8961_RS11835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11835	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS11840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS11840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS11840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11840	COG3321	synthase
M8961_RS11845	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS11845	COG0300	oxidoreductase activity
M8961_RS11845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11845	COG3321	synthase
M8961_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8961_RS11850	COG3321	synthase
M8961_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS11850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS11860	COG0318	PFAM AMP-dependent synthetase and ligase
M8961_RS11875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M8961_RS11875	COG2070	2-Nitropropane dioxygenase
M8961_RS11880	COG0250	Participates in transcription elongation, termination and antitermination
M8961_RS11900	COG0596	Alpha beta hydrolase
M8961_RS11915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M8961_RS11920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M8961_RS11935	COG0706	membrane insertase activity
M8961_RS11940	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8961_RS11945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M8961_RS11950	COG0346	lactoylglutathione lyase activity
M8961_RS11960	COG1376	ErfK ybiS ycfS ynhG family protein
M8961_RS11965	COG4129	membrane
M8961_RS11970	COG1126	abc transporter atp-binding protein
M8961_RS11975	COG0765	amino acid transport
M8961_RS11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8961_RS11990	COG1597	lipid kinase activity
M8961_RS11995	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8961_RS12000	COG0022	dehydrogenase e1 component
M8961_RS12005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8961_RS12010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8961_RS12015	COG3426	butyrate kinase activity
M8961_RS12020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8961_RS12025	COG0280	phosphate acetyltransferase
M8961_RS12030	COG3290	protein histidine kinase activity
M8961_RS12030	COG3829	transcription factor binding
M8961_RS12040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M8961_RS12045	COG2079	MmgE PrpD family protein
M8961_RS12050	COG0372	Belongs to the citrate synthase family
M8961_RS12055	COG1960	acyl-CoA dehydrogenase activity
M8961_RS12060	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8961_RS12065	COG0183	Belongs to the thiolase family
M8961_RS12070	COG0584	glycerophosphoryl diester phosphodiesterase
M8961_RS12075	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS12100	COG1902	pentaerythritol trinitrate reductase activity
M8961_RS12115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8961_RS12120	COG0745	RESPONSE REGULATOR receiver
M8961_RS12125	COG0750	zinc metalloprotease
M8961_RS12130	COG0497	DNA recombination
M8961_RS12140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M8961_RS12150	COG0142	geranyltranstransferase activity
M8961_RS12160	COG1570	exodeoxyribonuclease VII activity
M8961_RS12175	COG1302	Protein conserved in bacteria
M8961_RS12180	COG0439	Biotin carboxylase
M8961_RS12185	COG0511	ligase activity, forming carbon-carbon bonds
M8961_RS12225	COG3854	ATPases associated with a variety of cellular activities
M8961_RS12240	COG0006	proline dipeptidase activity
M8961_RS12250	COG3872	metal-dependent enzyme
M8961_RS12260	COG1752	Esterase of the alpha-beta hydrolase superfamily
M8961_RS12275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8961_RS12295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8961_RS12310	COG1396	sequence-specific DNA binding
M8961_RS12320	COG0681	Belongs to the peptidase S26 family
M8961_RS12345	COG4940	Competence protein ComGF
M8961_RS12355	COG4970	Tfp pilus assembly protein FimT
M8961_RS12360	COG4537	Required for transformation and DNA binding
M8961_RS12365	COG1459	type II secretion system
M8961_RS12370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M8961_RS12375	COG0598	Magnesium transport protein CorA
M8961_RS12380	COG1253	flavin adenine dinucleotide binding
M8961_RS12385	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS12395	COG1393	Belongs to the ArsC family
M8961_RS12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M8961_RS12415	COG0011	TIGRFAM Protein of
M8961_RS12425	COG2866	Carboxypeptidase
M8961_RS12430	COG1940	carbohydrate kinase activity
M8961_RS12435	COG4483	Protein conserved in bacteria
M8961_RS12440	COG1757	Na H antiporter
M8961_RS12450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M8961_RS12465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M8961_RS12470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8961_RS12475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8961_RS12480	COG0581	inorganic phosphate transmembrane transporter activity
M8961_RS12485	COG0573	inorganic phosphate transmembrane transporter activity
M8961_RS12490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M8961_RS12500	COG3859	Proton-coupled thiamine transporter YuaJ
M8961_RS12505	COG2268	Band 7 protein
M8961_RS12510	COG1585	Membrane protein implicated in regulation of membrane protease activity
M8961_RS12515	COG2318	DinB family
M8961_RS12525	COG1454	alcohol dehydrogenase
M8961_RS12530	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS12535	COG1510	regulation of RNA biosynthetic process
M8961_RS12545	COG0569	domain protein
M8961_RS12550	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8961_RS12555	COG1017	nitric oxide dioxygenase activity
M8961_RS12555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M8961_RS12580	COG0628	permease
M8961_RS12585	COG0673	inositol 2-dehydrogenase activity
M8961_RS12590	COG0693	protein deglycase activity
M8961_RS12595	COG0840	transmembrane signaling receptor activity
M8961_RS12600	COG0840	transmembrane signaling receptor activity
M8961_RS12605	COG0840	transmembrane signaling receptor activity
M8961_RS12610	COG0840	transmembrane signaling receptor activity
M8961_RS12625	COG2070	2-Nitropropane dioxygenase
M8961_RS12630	COG0432	Pfam Uncharacterised protein family UPF0047
M8961_RS12635	COG0366	Alpha amylase catalytic
M8961_RS12640	COG1253	flavin adenine dinucleotide binding
M8961_RS12645	COG2738	Putative neutral zinc metallopeptidase
M8961_RS12660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M8961_RS12685	COG1335	isochorismatase
M8961_RS12690	COG1979	alcohol dehydrogenase
M8961_RS12695	COG1979	alcohol dehydrogenase
M8961_RS12700	COG2155	Conserved Protein
M8961_RS12705	COG1098	S1 RNA binding domain
M8961_RS12710	COG0436	Aminotransferase
M8961_RS12715	COG1522	sequence-specific DNA binding
M8961_RS12720	COG2267	carboxylic ester hydrolase activity
M8961_RS12730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M8961_RS12735	COG2205	protein histidine kinase activity
M8961_RS12745	COG5018	Exonuclease
M8961_RS12750	COG2814	Major facilitator Superfamily
M8961_RS12755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8961_RS12760	COG3011	Protein conserved in bacteria
M8961_RS12770	COG3290	protein histidine kinase activity
M8961_RS12775	COG4565	transcriptional regulatory protein
M8961_RS12780	COG1744	ABC transporter substrate-binding protein PnrA-like
M8961_RS12785	COG3845	ABC transporter
M8961_RS12790	COG4603	Belongs to the binding-protein-dependent transport system permease family
M8961_RS12795	COG1079	Belongs to the binding-protein-dependent transport system permease family
M8961_RS12805	COG2111	Na H antiporter
M8961_RS12805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8961_RS12810	COG2111	Na H antiporter
M8961_RS12815	COG1006	Multisubunit Na H antiporter MnhC subunit
M8961_RS12820	COG0651	ATP synthesis coupled electron transport
M8961_RS12825	COG1863	multisubunit Na H antiporter MnhE subunit
M8961_RS12830	COG2212	antiporter activity
M8961_RS12835	COG1320	monovalent cation:proton antiporter activity
M8961_RS12840	COG2050	protein possibly involved in aromatic compounds catabolism
M8961_RS12845	COG2197	response regulator
M8961_RS12850	COG4585	Histidine kinase
M8961_RS12875	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M8961_RS12880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M8961_RS12885	COG1335	isochorismatase
M8961_RS12890	COG5506	Protein of unknown function (DUF1694)
M8961_RS12905	COG0628	permease
M8961_RS12915	COG1418	mRNA catabolic process
M8961_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS12930	COG1511	domain protein
M8961_RS12935	COG1674	ftsk spoiiie
M8961_RS12935	COG0433	COG0433 Predicted ATPase
M8961_RS12940	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8961_RS12945	COG5417	Belongs to the EsaB family
M8961_RS12950	COG4842	Belongs to the WXG100 family
M8961_RS12955	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M8961_RS12955	COG2508	Transcriptional regulator
M8961_RS12960	COG0686	Belongs to the AlaDH PNT family
M8961_RS12965	COG5634	Uncharacterized conserved protein (DUF2278)
M8961_RS12970	COG3251	PFAM MbtH domain protein
M8961_RS12975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS12980	COG3433	isochorismatase activity
M8961_RS12980	COG1535	isochorismatase
M8961_RS12985	COG1021	2,3-dihydroxybenzoate-AMP ligase
M8961_RS12990	COG1169	isochorismate synthase
M8961_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS13000	COG2819	hydrolase of the alpha beta superfamily
M8961_RS13005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8961_RS13010	COG1268	BioY protein
M8961_RS13015	COG2056	Na+-H+ antiporter family
M8961_RS13025	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M8961_RS13030	COG3584	3D domain protein
M8961_RS13045	COG1252	NADH dehydrogenase
M8961_RS13075	COG1131	(ABC) transporter
M8961_RS13095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8961_RS13100	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M8961_RS13105	COG0316	Belongs to the HesB IscA family
M8961_RS13115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8961_RS13125	COG1252	NADH dehydrogenase
M8961_RS13130	COG4837	Protein of unknown function (DUF1462)
M8961_RS13135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M8961_RS13140	COG0823	Involved in the tonB-independent uptake of proteins
M8961_RS13140	COG4946	Tricorn protease homolog
M8961_RS13140	COG1506	peptidase
M8961_RS13150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M8961_RS13155	COG0460	homoserine dehydrogenase
M8961_RS13160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8961_RS13165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M8961_RS13170	COG0647	UMP catabolic process
M8961_RS13175	COG2445	Protein of unknown function DUF86
M8961_RS13180	COG4470	Protein conserved in bacteria
M8961_RS13190	COG0739	heme binding
M8961_RS13200	COG0737	Belongs to the 5'-nucleotidase family
M8961_RS13205	COG0730	response to heat
M8961_RS13210	COG1801	Protein of unknown function DUF72
M8961_RS13225	COG2508	Transcriptional regulator
M8961_RS13235	COG2814	Major facilitator Superfamily
M8961_RS13240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M8961_RS13245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8961_RS13250	COG2356	endonuclease I
M8961_RS13255	COG3842	ATPase activity
M8961_RS13260	COG2188	Transcriptional regulator
M8961_RS13265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8961_RS13270	COG0395	ABC-type sugar transport system, permease component
M8961_RS13275	COG1175	transmembrane transport
M8961_RS13280	COG1653	transport
M8961_RS13285	COG2222	sugar isomerase
M8961_RS13290	COG0789	Transcriptional regulator
M8961_RS13305	COG0322	excinuclease ABC activity
M8961_RS13310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8961_RS13315	COG2226	methyltransferase
M8961_RS13325	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS13330	COG0719	Fe-S assembly protein
M8961_RS13335	COG0822	iron-sulfur transferase activity
M8961_RS13340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8961_RS13345	COG0719	Fe-S assembly protein
M8961_RS13350	COG0396	ATPase activity
M8961_RS13360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M8961_RS13365	COG1464	Belongs to the NlpA lipoprotein family
M8961_RS13370	COG2011	ABC-type metal ion transport system permease component
M8961_RS13375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8961_RS13385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS13390	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8961_RS13405	COG1393	Belongs to the ArsC family
M8961_RS13410	COG1960	acyl-CoA dehydrogenase activity
M8961_RS13415	COG0183	Belongs to the thiolase family
M8961_RS13420	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8961_RS13420	COG1024	Enoyl-CoA hydratase
M8961_RS13440	COG5577	PFAM Coat F domain
M8961_RS13445	COG1846	Transcriptional regulator
M8961_RS13450	COG0477	Major facilitator Superfamily
M8961_RS13455	COG1942	4-Oxalocrotonate Tautomerase
M8961_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS13465	COG0583	DNA-binding transcription factor activity
M8961_RS13480	COG0583	DNA-binding transcription factor activity
M8961_RS13500	COG1120	ATPase activity
M8961_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS13520	COG0783	Belongs to the Dps family
M8961_RS13525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8961_RS13530	COG0745	RESPONSE REGULATOR receiver
M8961_RS13535	COG2770	Histidine kinase
M8961_RS13535	COG2205	protein histidine kinase activity
M8961_RS13545	COG1309	transcriptional regulator
M8961_RS13550	COG0114	fumarate hydratase activity
M8961_RS13560	COG0697	spore germination
M8961_RS13565	COG0814	amino acid
M8961_RS13575	COG2197	response regulator
M8961_RS13580	COG4585	Histidine kinase
M8961_RS13585	COG4758	membrane
M8961_RS13590	COG3595	metallopeptidase activity
M8961_RS13595	COG1842	Phage shock protein A
M8961_RS13600	COG4758	membrane
M8961_RS13605	COG2814	Major facilitator Superfamily
M8961_RS13610	COG2096	Adenosyltransferase
M8961_RS13615	COG1120	ATPase activity
M8961_RS13620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS13625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8961_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS13635	COG3386	PFAM SMP-30 Gluconolaconase
M8961_RS13640	COG2205	protein histidine kinase activity
M8961_RS13645	COG0745	RESPONSE REGULATOR receiver
M8961_RS13655	COG1191	sigma factor activity
M8961_RS13665	COG2140	Oxalate decarboxylase
M8961_RS13675	COG1120	ATPase activity
M8961_RS13680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS13685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS13690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8961_RS13695	COG0531	amino acid
M8961_RS13705	COG1988	membrane-bound metal-dependent
M8961_RS13710	COG1368	sulfuric ester hydrolase activity
M8961_RS13715	COG1910	domain protein
M8961_RS13720	COG0725	ABC transporter, periplasmic molybdate-binding protein
M8961_RS13725	COG4149	molybdate abc transporter
M8961_RS13730	COG2197	response regulator
M8961_RS13735	COG3850	Histidine kinase
M8961_RS13740	COG1131	(ABC) transporter
M8961_RS13750	COG0842	Transport permease protein
M8961_RS13755	COG0656	L-ascorbic acid biosynthetic process
M8961_RS13775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8961_RS13780	COG3973	AAA domain
M8961_RS13785	COG2860	membrane
M8961_RS13795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M8961_RS13800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M8961_RS13805	COG2217	Heavy metal translocating P-type atpase
M8961_RS13810	COG2217	Heavy metal translocating P-type atpase
M8961_RS13815	COG2608	mercury ion transmembrane transporter activity
M8961_RS13820	COG1937	Protein conserved in bacteria
M8961_RS13825	COG0673	inositol 2-dehydrogenase activity
M8961_RS13840	COG2814	Major facilitator Superfamily
M8961_RS13855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS13860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M8961_RS13865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS13870	COG1126	abc transporter atp-binding protein
M8961_RS13875	COG0765	amino acid transport
M8961_RS13880	COG0765	amino acid transport
M8961_RS13885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8961_RS13895	COG0454	-acetyltransferase
M8961_RS13900	COG0583	DNA-binding transcription factor activity
M8961_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS13910	COG2732	(Barnase) inhibitor
M8961_RS13925	COG0557	exoribonuclease II activity
M8961_RS13930	COG1647	Serine aminopeptidase, S33
M8961_RS13935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8961_RS13940	COG1476	TRANSCRIPTIONal
M8961_RS13945	COG1396	sequence-specific DNA binding
M8961_RS13950	COG1396	sequence-specific DNA binding
M8961_RS13955	COG1733	regulation of RNA biosynthetic process
M8961_RS13980	COG1131	(ABC) transporter
M8961_RS13985	COG1174	glycine betaine transport
M8961_RS13990	COG1732	Glycine betaine
M8961_RS13995	COG1174	glycine betaine transport
M8961_RS14000	COG0517	IMP dehydrogenase activity
M8961_RS14000	COG1125	glycine betaine transport
M8961_RS14005	COG1510	regulation of RNA biosynthetic process
M8961_RS14010	COG1174	glycine betaine transport
M8961_RS14015	COG1732	Glycine betaine
M8961_RS14020	COG1174	glycine betaine transport
M8961_RS14025	COG1125	glycine betaine transport
M8961_RS14025	COG0517	IMP dehydrogenase activity
M8961_RS14030	COG1510	regulation of RNA biosynthetic process
M8961_RS14035	COG2095	MarC family integral membrane protein
M8961_RS14040	COG3064	Membrane
M8961_RS14045	COG4640	response to antibiotic
M8961_RS14050	COG0456	acetyltransferase
M8961_RS14065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8961_RS14080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8961_RS14085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS14090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8961_RS14100	COG2234	aminopeptidase activity
M8961_RS14120	COG0126	phosphoglycerate kinase activity
M8961_RS14125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8961_RS14130	COG2390	Transcriptional regulator
M8961_RS14135	COG2814	Major facilitator Superfamily
M8961_RS14140	COG1609	Transcriptional regulator
M8961_RS14145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS14155	COG0583	DNA-binding transcription factor activity
M8961_RS14160	COG0697	spore germination
M8961_RS14165	COG1113	amino acid transport
M8961_RS14175	COG1609	Transcriptional regulator
M8961_RS14185	COG0561	phosphatase activity
M8961_RS14190	COG1737	Transcriptional regulator
M8961_RS14195	COG1070	Carbohydrate kinase
M8961_RS14220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8961_RS14225	COG2186	Transcriptional regulator
M8961_RS14230	COG1620	l-lactate permease
M8961_RS14235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M8961_RS14245	COG5039	Polysaccharide pyruvyl transferase
M8961_RS14250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8961_RS14255	COG0110	maltose O-acetyltransferase activity
M8961_RS14260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M8961_RS14265	COG2244	polysaccharide biosynthetic process
M8961_RS14270	COG1216	Glycosyl transferase, family 2
M8961_RS14275	COG5039	Polysaccharide pyruvyl transferase
M8961_RS14280	COG1216	Glycosyl transferase, family 2
M8961_RS14290	COG0438	transferase activity, transferring glycosyl groups
M8961_RS14295	COG1215	transferase activity, transferring glycosyl groups
M8961_RS14300	COG0438	transferase activity, transferring glycosyl groups
M8961_RS14305	COG1086	Polysaccharide biosynthesis protein
M8961_RS14310	COG0489	protein tyrosine kinase activity
M8961_RS14315	COG3944	biosynthesis protein
M8961_RS14320	COG1396	sequence-specific DNA binding
M8961_RS14325	COG2272	Belongs to the type-B carboxylesterase lipase family
M8961_RS14330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M8961_RS14335	COG2364	Membrane
M8961_RS14340	COG0456	acetyltransferase
M8961_RS14345	COG3479	Phenolic acid decarboxylase
M8961_RS14400	COG2223	nitrite transmembrane transporter activity
M8961_RS14405	COG1609	Transcriptional regulator
M8961_RS14415	COG0583	DNA-binding transcription factor activity
M8961_RS14420	COG2828	Protein conserved in bacteria
M8961_RS14425	COG0477	Major facilitator Superfamily
M8961_RS14425	COG2814	Major facilitator Superfamily
M8961_RS14430	COG1611	Belongs to the LOG family
M8961_RS14435	COG1694	Mazg nucleotide pyrophosphohydrolase
M8961_RS14440	COG0659	secondary active sulfate transmembrane transporter activity
M8961_RS14445	COG0288	reversible hydration of carbon dioxide
M8961_RS14450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8961_RS14455	COG4290	ribonuclease
M8961_RS14460	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M8961_RS14465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS14475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M8961_RS14485	COG1051	belongs to the nudix hydrolase family
M8961_RS14490	COG0492	ferredoxin-NADP+ reductase activity
M8961_RS14495	COG0791	NLP P60 protein
M8961_RS14495	COG3883	PFAM NLP P60 protein
M8961_RS14500	COG0457	Tetratricopeptide repeat
M8961_RS14505	COG5002	protein histidine kinase activity
M8961_RS14510	COG0745	RESPONSE REGULATOR receiver
M8961_RS14515	COG1132	(ABC) transporter
M8961_RS14520	COG0140	phosphoribosyl-ATP diphosphatase activity
M8961_RS14520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M8961_RS14545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M8961_RS14560	COG4990	cell redox homeostasis
M8961_RS14565	COG0110	maltose O-acetyltransferase activity
M8961_RS14585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M8961_RS14595	COG2188	Transcriptional regulator
M8961_RS14600	COG1309	transcriptional regulator
M8961_RS14605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M8961_RS14610	COG1950	PFAM Membrane protein of
M8961_RS14615	COG1983	PspC domain protein
M8961_RS14620	COG3595	metallopeptidase activity
M8961_RS14635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M8961_RS14645	COG4897	Protein conserved in bacteria
M8961_RS14650	COG3848	Pyruvate phosphate dikinase
M8961_RS14650	COG0574	Belongs to the PEP-utilizing enzyme family
M8961_RS14655	COG1309	transcriptional regulator
M8961_RS14660	COG2814	Major facilitator Superfamily
M8961_RS14665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8961_RS14675	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS14675	COG0793	Belongs to the peptidase S41A family
M8961_RS14680	COG3420	alginic acid biosynthetic process
M8961_RS14685	COG2177	Part of the ABC transporter FtsEX involved in
M8961_RS14690	COG2884	Cell division ATP-binding protein ftsE
M8961_RS14695	COG2010	Cytochrome c
M8961_RS14700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS14715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M8961_RS14730	COG1516	flagellar protein fliS
M8961_RS14735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M8961_RS14740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8961_RS14760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M8961_RS14765	COG1256	bacterial-type flagellum assembly
M8961_RS14765	COG4786	Flagellar basal body rod
M8961_RS14770	COG3418	PFAM FlgN family protein
M8961_RS14775	COG2747	anti-sigma28 factor FlgM
M8961_RS14785	COG1040	competence protein
M8961_RS14795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M8961_RS14800	COG1307	EDD domain protein, DegV family
M8961_RS14805	COG2197	response regulator
M8961_RS14810	COG4585	Histidine kinase
M8961_RS14815	COG1739	Uncharacterized protein family UPF0029
M8961_RS14820	COG1316	TRANSCRIPTIONal
M8961_RS14825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8961_RS14830	COG0438	transferase activity, transferring glycosyl groups
M8961_RS14835	COG1215	transferase activity, transferring glycosyl groups
M8961_RS14840	COG3206	protein involved in exopolysaccharide biosynthesis
M8961_RS14845	COG3307	-O-antigen
M8961_RS14850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8961_RS14855	COG0438	transferase activity, transferring glycosyl groups
M8961_RS14855	COG0297	glycogen (starch) synthase activity
M8961_RS14860	COG2244	polysaccharide biosynthetic process
M8961_RS14870	COG2247	cell wall binding repeat
M8961_RS14870	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS14875	COG2385	sporulation resulting in formation of a cellular spore
M8961_RS14875	COG2247	cell wall binding repeat
M8961_RS14885	COG1316	TRANSCRIPTIONal
M8961_RS14890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M8961_RS14895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8961_RS14900	COG1134	teichoic acid transport
M8961_RS14905	COG1682	transport, permease protein
M8961_RS14910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8961_RS14920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M8961_RS14925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M8961_RS14930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8961_RS14935	COG4193	domain, Protein
M8961_RS14940	COG1482	cell wall glycoprotein biosynthetic process
M8961_RS14945	COG0697	spore germination
M8961_RS14950	COG0814	amino acid
M8961_RS14960	COG1215	transferase activity, transferring glycosyl groups
M8961_RS14965	COG2814	Major facilitator Superfamily
M8961_RS14970	COG1316	TRANSCRIPTIONal
M8961_RS14975	COG0561	phosphatase activity
M8961_RS14980	COG2433	Pfam Transposase IS66
M8961_RS14985	COG0791	NLP P60 protein
M8961_RS14995	COG2843	Capsule synthesis protein
M8961_RS15005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8961_RS15015	COG0814	amino acid
M8961_RS15025	COG1609	Transcriptional regulator
M8961_RS15030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8961_RS15040	COG1129	ABC transporter
M8961_RS15045	COG1172	Belongs to the binding-protein-dependent transport system permease family
M8961_RS15050	COG1879	ABC-type sugar transport system periplasmic component
M8961_RS15055	COG3103	Sh3 type 3 domain protein
M8961_RS15060	COG2249	NAD(P)H dehydrogenase (quinone) activity
M8961_RS15065	COG3527	Alpha-acetolactate decarboxylase
M8961_RS15070	COG0028	Belongs to the TPP enzyme family
M8961_RS15075	COG0583	DNA-binding transcription factor activity
M8961_RS15080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8961_RS15095	COG5337	Spore coat protein CotH
M8961_RS15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8961_RS15110	COG0405	Gamma-glutamyltransferase
M8961_RS15115	COG1522	sequence-specific DNA binding
M8961_RS15120	COG2059	Chromate
M8961_RS15125	COG2059	Chromate
M8961_RS15180	COG5444	nuclease activity
M8961_RS15195	COG3878	Protein conserved in bacteria
M8961_RS15200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M8961_RS15205	COG4464	protein tyrosine phosphatase activity
M8961_RS15210	COG0489	protein tyrosine kinase activity
M8961_RS15215	COG3944	biosynthesis protein
M8961_RS15225	COG4715	Zinc finger, swim domain protein
M8961_RS15230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M8961_RS15235	COG0561	phosphatase activity
M8961_RS15240	COG1349	DNA-binding transcription factor activity
M8961_RS15245	COG0629	single-stranded DNA binding
M8961_RS15270	COG0457	Tetratricopeptide repeat
M8961_RS15275	COG4786	Flagellar basal body rod
M8961_RS15280	COG4786	Flagellar basal body rod
M8961_RS15285	COG1077	Cell shape determining protein MreB Mrl
M8961_RS15290	COG1609	Transcriptional regulator
M8961_RS15295	COG1846	Transcriptional regulator
M8961_RS15300	COG2814	Major facilitator Superfamily
M8961_RS15305	COG1953	Uracil, thiamine, allantoin
M8961_RS15310	COG0477	Major facilitator Superfamily
M8961_RS15315	COG1335	isochorismatase
M8961_RS15320	COG0004	ammonium transporteR
M8961_RS15325	COG0347	Belongs to the P(II) protein family
M8961_RS15330	COG0772	Belongs to the SEDS family
M8961_RS15335	COG0671	phosphoesterase, PA-phosphatase related
M8961_RS15345	COG0739	heme binding
M8961_RS15350	COG1247	-acetyltransferase
M8961_RS15365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8961_RS15375	COG0726	polysaccharide deacetylase
M8961_RS15380	COG1959	2 iron, 2 sulfur cluster binding
M8961_RS15395	COG0831	urea catabolic process
M8961_RS15400	COG3237	CsbD-like
M8961_RS15405	COG1994	Peptidase M50
M8961_RS15410	COG0457	Tetratricopeptide repeat
M8961_RS15420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M8961_RS15430	COG2304	oxidoreductase activity
M8961_RS15435	COG2304	oxidoreductase activity
M8961_RS15440	COG2385	sporulation resulting in formation of a cellular spore
M8961_RS15445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8961_RS15455	COG4836	Membrane
M8961_RS15525	COG0698	ribose 5-phosphate isomerase
M8961_RS15530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8961_RS15540	COG0009	L-threonylcarbamoyladenylate synthase
M8961_RS15545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M8961_RS15565	COG2890	protein-(glutamine-N5) methyltransferase activity
M8961_RS15570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M8961_RS15575	COG0346	lactoylglutathione lyase activity
M8961_RS15580	COG0789	Transcriptional regulator
M8961_RS15585	COG0679	Auxin Efflux Carrier
M8961_RS15590	COG0281	malic enzyme
M8961_RS15605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M8961_RS15615	COG1494	fructose-1,6-bisphosphatase
M8961_RS15620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8961_RS15630	COG0191	fructose-bisphosphate aldolase activity
M8961_RS15635	COG2204	response regulator
M8961_RS15640	COG4821	SIS domain
M8961_RS15655	COG0247	lactate metabolic process
M8961_RS15655	COG2181	nitrate reductase activity
M8961_RS15660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8961_RS15675	COG1132	(ABC) transporter
M8961_RS15680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8961_RS15690	COG2181	nitrate reductase activity
M8961_RS15695	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M8961_RS15700	COG1140	nitrate reductase beta subunit
M8961_RS15705	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M8961_RS15710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8961_RS15720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8961_RS15725	COG2223	nitrite transmembrane transporter activity
M8961_RS15735	COG4506	Protein conserved in bacteria
M8961_RS15745	COG3391	amine dehydrogenase activity
M8961_RS15750	COG3391	amine dehydrogenase activity
M8961_RS15755	COG0457	Tetratricopeptide repeat
M8961_RS15795	COG0010	Belongs to the arginase family
M8961_RS15800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M8961_RS15805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8961_RS15820	COG1994	Peptidase M50
M8961_RS15825	COG1942	4-Oxalocrotonate Tautomerase
M8961_RS15830	COG1846	Transcriptional regulator
M8961_RS15835	COG0531	amino acid
M8961_RS15840	COG3465	dGTPase activity
M8961_RS15845	COG1078	dGTPase activity
M8961_RS15860	COG1695	Transcriptional regulator
M8961_RS15870	COG1131	(ABC) transporter
M8961_RS15875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M8961_RS15905	COG0583	DNA-binding transcription factor activity
M8961_RS15910	COG2855	membrane
M8961_RS15915	COG0280	phosphate acetyltransferase
M8961_RS15925	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS15930	COG0436	Aminotransferase
M8961_RS15960	COG2814	Major facilitator Superfamily
M8961_RS15965	COG2814	Major facilitator Superfamily
M8961_RS15970	COG0833	amino acid
M8961_RS15975	COG4187	Peptidase family M20/M25/M40
M8961_RS15980	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS15985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M8961_RS15990	COG2205	protein histidine kinase activity
M8961_RS15995	COG0745	RESPONSE REGULATOR receiver
M8961_RS16010	COG1131	(ABC) transporter
M8961_RS16015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M8961_RS16020	COG1091	dTDP-4-dehydrorhamnose reductase activity
M8961_RS16025	COG1088	dTDP-glucose 4,6-dehydratase activity
M8961_RS16030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M8961_RS16035	COG3980	spore coat polysaccharide biosynthesis protein
M8961_RS16040	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M8961_RS16045	COG2089	acid synthase
M8961_RS16050	COG0456	acetyltransferase
M8961_RS16055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M8961_RS16060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8961_RS16065	COG0463	Glycosyl transferase, family 2
M8961_RS16075	COG2363	Small membrane protein
M8961_RS16080	COG2233	PERMEase
M8961_RS16095	COG1216	Glycosyl transferase, family 2
M8961_RS16110	COG1695	Transcriptional regulator
M8961_RS16115	COG0351	phosphomethylpyrimidine kinase
M8961_RS16125	COG1621	beta-fructofuranosidase activity
M8961_RS16130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS16130	COG1263	PTS System
M8961_RS16135	COG3711	transcriptional antiterminator
M8961_RS16145	COG1404	Belongs to the peptidase S8 family
M8961_RS16150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS16175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS16185	COG1733	regulation of RNA biosynthetic process
M8961_RS16190	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M8961_RS16195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M8961_RS16200	COG3209	COG3209 Rhs family protein
M8961_RS16210	COG2723	6-phospho-beta-galactosidase activity
M8961_RS16220	COG1714	RDD family
M8961_RS16225	COG1063	alcohol dehydrogenase
M8961_RS16230	COG0523	cobalamin synthesis protein
M8961_RS16235	COG2223	nitrite transmembrane transporter activity
M8961_RS16240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8961_RS16245	COG0243	molybdopterin cofactor binding
M8961_RS16250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8961_RS16255	COG2146	nitrite reductase [NAD(P)H] activity
M8961_RS16260	COG1587	Uroporphyrinogen-III synthase
M8961_RS16260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M8961_RS16270	COG2508	Transcriptional regulator
M8961_RS16275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8961_RS16280	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS16285	COG0506	proline dehydrogenase activity
M8961_RS16290	COG3541	Predicted nucleotidyltransferase
M8961_RS16295	COG3458	cephalosporin-C deacetylase activity
M8961_RS16300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M8961_RS16305	COG2271	Major facilitator Superfamily
M8961_RS16310	COG1082	Xylose isomerase domain protein TIM barrel
M8961_RS16315	COG1660	Displays ATPase and GTPase activities
M8961_RS16330	COG3665	Urea carboxylase-associated protein
M8961_RS16335	COG1113	amino acid transport
M8961_RS16340	COG3403	YqcI/YcgG family
M8961_RS16345	COG1280	lysine exporter protein (LysE YggA)
M8961_RS16350	COG1846	Transcriptional regulator
M8961_RS16355	COG2814	Major facilitator Superfamily
M8961_RS16365	COG0366	Alpha amylase catalytic
M8961_RS16375	COG1288	antiporter activity
M8961_RS16380	COG1473	amidohydrolase
M8961_RS16385	COG2113	Glycine betaine
M8961_RS16390	COG4176	ABC-type proline glycine betaine transport system permease component
M8961_RS16395	COG4175	Glycine betaine
M8961_RS16395	COG0517	IMP dehydrogenase activity
M8961_RS16400	COG0477	Major facilitator Superfamily
M8961_RS16405	COG3853	Toxic anion resistance protein (TelA)
M8961_RS16415	COG0861	Integral membrane protein TerC family
M8961_RS16420	COG2310	stress, protein
M8961_RS16425	COG2310	stress, protein
M8961_RS16430	COG2310	stress, protein
M8961_RS16435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8961_RS16440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8961_RS16445	COG1121	(ABC) transporter
M8961_RS16450	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8961_RS16455	COG0366	Alpha amylase catalytic
M8961_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS16465	COG0457	Tetratricopeptide repeat
M8961_RS16470	COG1876	peptidase activity
M8961_RS16475	COG1595	DNA-templated transcription, initiation
M8961_RS16480	COG1595	DNA-templated transcription, initiation
M8961_RS16490	COG0667	Aldo Keto reductase
M8961_RS16495	COG1405	negative regulation of cell septum assembly
M8961_RS16495	COG3012	SEC-C Motif Domain Protein
M8961_RS16500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M8961_RS16505	COG0252	asparaginase activity
M8961_RS16510	COG1309	transcriptional regulator
M8961_RS16515	COG0477	Major facilitator Superfamily
M8961_RS16520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8961_RS16530	COG0805	protein transport
M8961_RS16535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8961_RS16540	COG3540	Alkaline phosphatase
M8961_RS16545	COG3773	Cell wall hydrolase
M8961_RS16555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8961_RS16560	COG2259	Doxx family
M8961_RS16565	COG0346	lactoylglutathione lyase activity
M8961_RS16570	COG0778	Nitroreductase
M8961_RS16575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8961_RS16595	COG0784	Response regulator, receiver
M8961_RS16600	COG4191	Histidine kinase
M8961_RS16605	COG2066	Belongs to the glutaminase family
M8961_RS16610	COG1115	amino acid carrier protein
M8961_RS16615	COG2040	homocysteine
M8961_RS16620	COG0833	amino acid
M8961_RS16625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8961_RS16630	COG1301	dicarboxylic acid transport
M8961_RS16645	COG0688	phosphatidylethanolamine metabolic process
M8961_RS16650	COG0586	Pfam SNARE associated Golgi protein
M8961_RS16655	COG1183	phosphatidylcholine synthase activity
M8961_RS16665	COG0371	Dehydrogenase
M8961_RS16680	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS16690	COG2368	4-hydroxyphenylacetate
M8961_RS16700	COG2271	Major facilitator Superfamily
M8961_RS16705	COG0584	glycerophosphoryl diester phosphodiesterase
M8961_RS16720	COG0531	amino acid
M8961_RS16760	COG1131	(ABC) transporter
M8961_RS16765	COG2197	response regulator
M8961_RS16770	COG4585	Histidine kinase
M8961_RS16775	COG1011	Hydrolase
M8961_RS16780	COG1113	amino acid transport
M8961_RS16785	COG1846	Transcriptional regulator
M8961_RS16790	COG1380	Effector of murein hydrolase LrgA
M8961_RS16795	COG1346	cytolysis
M8961_RS16810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8961_RS16815	COG0577	efflux transmembrane transporter activity
M8961_RS16820	COG1136	(ABC) transporter
M8961_RS16825	COG2205	protein histidine kinase activity
M8961_RS16865	COG4856	YbbR-like protein
M8961_RS16870	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8961_RS16875	COG5662	AntiSigma factor
M8961_RS16880	COG1595	DNA-templated transcription, initiation
M8961_RS16910	COG1683	Conserved Protein
M8961_RS16915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8961_RS16925	COG1263	PTS System
M8961_RS16925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS16930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M8961_RS16935	COG1472	Belongs to the glycosyl hydrolase 3 family
M8961_RS16940	COG3876	Protein conserved in bacteria
M8961_RS16945	COG2207	Transcriptional regulator
M8961_RS16945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8961_RS16950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8961_RS16955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS16960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS16965	COG2819	hydrolase of the alpha beta superfamily
M8961_RS16970	COG0385	Bile acid
M8961_RS16975	COG0659	secondary active sulfate transmembrane transporter activity
M8961_RS16990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M8961_RS16995	COG0738	Major facilitator superfamily
M8961_RS17010	COG0471	metal ion transport
M8961_RS17015	COG3866	Pectate lyase
M8961_RS17030	COG2130	NADP-dependent
M8961_RS17040	COG0513	Belongs to the DEAD box helicase family
M8961_RS17045	COG0488	(ABC) transporter
M8961_RS17050	COG2814	Major facilitator Superfamily
M8961_RS17055	COG0789	Transcriptional regulator
M8961_RS17060	COG0488	(ABC) transporter
M8961_RS17065	COG0463	Glycosyl transferase, family 2
M8961_RS17065	COG0457	Tetratricopeptide repeat
M8961_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
M8961_RS17075	COG0840	transmembrane signaling receptor activity
M8961_RS17080	COG1012	belongs to the aldehyde dehydrogenase family
M8961_RS17085	COG0531	amino acid
M8961_RS17090	COG2223	nitrite transmembrane transporter activity
M8961_RS17095	COG1442	glycosyl transferase family 8
M8961_RS17100	COG1216	Glycosyl transferase, family 2
M8961_RS17105	COG1442	glycosyl transferase family 8
M8961_RS17110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8961_RS17115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M8961_RS17120	COG1368	sulfuric ester hydrolase activity
M8961_RS17125	COG4106	trans-aconitate 2-methyltransferase activity
M8961_RS17170	COG1131	(ABC) transporter
M8961_RS17185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8961_RS17185	COG2124	cytochrome p450
M8961_RS17195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M8961_RS17200	COG1846	Transcriptional regulator
M8961_RS17205	COG0670	Belongs to the BI1 family
M8961_RS17210	COG0196	riboflavin kinase activity
M8961_RS17215	COG5583	Uncharacterized small protein (DUF2292)
M8961_RS17220	COG1366	Belongs to the anti-sigma-factor antagonist family
M8961_RS17225	COG0346	lactoylglutathione lyase activity
M8961_RS17230	COG2329	Antibiotic biosynthesis monooxygenase
M8961_RS17235	COG2323	membrane
M8961_RS17245	COG0454	-acetyltransferase
M8961_RS17250	COG3546	catalase activity
M8961_RS17280	COG5444	nuclease activity
M8961_RS17310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M8961_RS17320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M8961_RS17325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8961_RS17330	COG1597	lipid kinase activity
M8961_RS17335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8961_RS17340	COG1309	transcriptional regulator
M8961_RS17360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8961_RS17365	COG1285	pathogenesis
M8961_RS17370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M8961_RS17375	COG4851	CamS sex pheromone cAM373 precursor
M8961_RS17385	COG0210	DNA helicase
M8961_RS17395	COG0069	glutamate synthase activity
M8961_RS17400	COG4496	protein, YerC YecD
M8961_RS17405	COG1470	cell adhesion involved in biofilm formation
M8961_RS17410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M8961_RS17425	COG0151	Belongs to the GarS family
M8961_RS17430	COG0138	bifunctional purine biosynthesis protein purh
M8961_RS17435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M8961_RS17445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M8961_RS17460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8961_RS17465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M8961_RS17470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M8961_RS17475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M8961_RS17480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M8961_RS17500	COG3064	Membrane
M8961_RS17505	COG2252	PERMEase
M8961_RS17525	COG1305	Transglutaminase-like
M8961_RS17530	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M8961_RS17535	COG0714	Associated with various cellular activities
M8961_RS17540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8961_RS17545	COG1113	amino acid transport
M8961_RS17550	COG2132	Multicopper oxidase
M8961_RS17565	COG0823	Involved in the tonB-independent uptake of proteins
M8961_RS17570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8961_RS17575	COG1063	alcohol dehydrogenase
M8961_RS17580	COG1595	DNA-templated transcription, initiation
M8961_RS17590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M8961_RS17590	COG2755	lipolytic protein G-D-S-L family
M8961_RS17595	COG4260	virion core protein, lumpy skin disease virus
M8961_RS17600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M8961_RS17605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8961_RS17610	COG1842	Phage shock protein A
M8961_RS17620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8961_RS17625	COG2211	Major facilitator Superfamily
M8961_RS17630	COG1063	alcohol dehydrogenase
M8961_RS17635	COG0457	Tetratricopeptide repeat
M8961_RS17655	COG3409	Peptidoglycan-binding domain 1 protein
M8961_RS17670	COG1266	CAAX protease self-immunity
M8961_RS17680	COG0805	protein transport
M8961_RS17685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M8961_RS17700	COG0488	(ABC) transporter
M8961_RS17705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M8961_RS17710	COG0456	acetyltransferase
M8961_RS17715	COG1214	PFAM Peptidase M22, glycoprotease
M8961_RS17720	COG0802	atpase or kinase
M8961_RS17725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M8961_RS17740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8961_RS17770	COG0561	phosphatase activity
M8961_RS17775	COG2390	Transcriptional regulator
M8961_RS17785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8961_RS17790	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M8961_RS17795	COG0833	amino acid
M8961_RS17800	COG0010	Belongs to the arginase family
M8961_RS17825	COG3507	Belongs to the glycosyl hydrolase 43 family
M8961_RS17830	COG0494	nUDIX hydrolase
M8961_RS17840	COG1263	PTS System
M8961_RS17840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8961_RS17840	COG2190	(PTS) system
M8961_RS17845	COG2723	6-phospho-beta-galactosidase activity
M8961_RS17850	COG0589	response to stress
M8961_RS17855	COG0697	spore germination
M8961_RS17905	COG0513	Belongs to the DEAD box helicase family
M8961_RS17910	COG2270	Major facilitator Superfamily
M8961_RS17915	COG3711	transcriptional antiterminator
M8961_RS17920	COG2273	Hydrolase Family 16
M8961_RS17925	COG2851	Citrate transporter
M8961_RS17930	COG0693	protein deglycase activity
M8961_RS17930	COG0753	catalase activity
M8961_RS17945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8961_RS17950	COG0500	methyltransferase
M8961_RS17955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M8961_RS17960	COG4894	glucomannan catabolic process
M8961_RS17975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M8961_RS17985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8961_RS17990	COG2508	Transcriptional regulator
M8961_RS17995	COG3842	ATPase activity
M8961_RS18000	COG0726	polysaccharide deacetylase
M8961_RS18005	COG3493	citrate carrier protein
M8961_RS18010	COG1271	oxidase subunit
M8961_RS18015	COG1294	oxidase, subunit
M8961_RS18020	COG4988	ABC transporter
M8961_RS18025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M8961_RS18030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M8961_RS18035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M8961_RS18040	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M8961_RS18045	COG0753	catalase activity
M8961_RS18055	COG1482	cell wall glycoprotein biosynthetic process
M8961_RS18060	COG1940	carbohydrate kinase activity
M8961_RS18065	COG2723	6-phospho-beta-galactosidase activity
M8961_RS18070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS18075	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8961_RS18080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS18085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8961_RS18090	COG0640	Transcriptional regulator
M8961_RS18100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS18105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8961_RS18115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8961_RS18115	COG3711	transcriptional antiterminator
M8961_RS18120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS18125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS18130	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8961_RS18135	COG1486	melibiose metabolic process
M8961_RS18140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8961_RS18145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M8961_RS18155	COG1696	Membrane protein involved in D-alanine export
M8961_RS18170	COG1575	Belongs to the MenA family. Type 1 subfamily
M8961_RS18175	COG2357	RelA SpoT domain protein
M8961_RS18180	COG1442	glycosyl transferase family 8
M8961_RS18185	COG1404	Belongs to the peptidase S8 family
M8961_RS18190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8961_RS18195	COG0346	lactoylglutathione lyase activity
M8961_RS18200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M8961_RS18205	COG5504	Zn-dependent protease
M8961_RS18210	COG0789	Transcriptional regulator
M8961_RS18215	COG4895	conserved protein (DUF2196)
M8961_RS18220	COG1346	cytolysis
M8961_RS18230	COG0583	DNA-binding transcription factor activity
M8961_RS18250	COG2837	iron assimilation
M8961_RS18255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8961_RS18275	COG1309	transcriptional regulator
M8961_RS18280	COG2246	polysaccharide biosynthetic process
M8961_RS18285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M8961_RS18290	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M8961_RS18295	COG2261	transglycosylase associated protein
M8961_RS18300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8961_RS18305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8961_RS18325	COG0454	-acetyltransferase
M8961_RS18330	COG0772	Belongs to the SEDS family
M8961_RS18335	COG0778	Nitroreductase
M8961_RS18345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS18350	COG0726	polysaccharide deacetylase
M8961_RS18355	COG2194	sulfuric ester hydrolase activity
M8961_RS18365	COG0489	protein tyrosine kinase activity
M8961_RS18370	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8961_RS18380	COG2318	DinB family
M8961_RS18385	COG2226	methyltransferase
M8961_RS18405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8961_RS18410	COG1122	ATPase activity
M8961_RS18415	COG1122	ATPase activity
M8961_RS18440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M8961_RS18455	COG0024	Methionine aminopeptidase
M8961_RS18465	COG0201	protein transport
M8961_RS18575	COG0596	Alpha beta hydrolase
M8961_RS18600	COG1358	cellular component organization or biogenesis
M8961_RS18615	COG2813	Specifically methylates the guanine in position
M8961_RS18640	COG0250	Participates in transcription elongation, termination and antitermination
M8961_RS18645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8961_RS18655	COG1595	DNA-templated transcription, initiation
M8961_RS18660	COG3688	RNA-binding protein containing a PIN domain
M8961_RS18665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8961_RS18670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M8961_RS18680	COG1045	serine acetyltransferase
M8961_RS18700	COG4956	integral membrane protein (PIN domain superfamily)
M8961_RS18705	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M8961_RS18710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M8961_RS18715	COG0542	response to heat
M8961_RS18725	COG3880	PFAM UvrB UvrC protein
M8961_RS18730	COG4463	regulation of RNA biosynthetic process
M8961_RS18885	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M8961_RS18890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M8961_RS18895	COG1169	isochorismate synthase
M8961_RS18905	COG0596	Alpha beta hydrolase
M8961_RS18910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M8961_RS18920	COG4948	Mandelate Racemase Muconate Lactonizing
M8961_RS18930	COG1294	oxidase, subunit
M8961_RS18935	COG1271	oxidase subunit
M8961_RS18945	COG0288	reversible hydration of carbon dioxide
M8961_RS18970	COG0783	Belongs to the Dps family
M8961_RS18975	COG4824	toxin secretion phage lysis holin
M8961_RS18980	COG0494	nUDIX hydrolase
M8961_RS18985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M8961_RS18990	COG1116	anion transmembrane transporter activity
M8961_RS18995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8961_RS19000	COG1506	peptidase
M8961_RS19020	COG0367	asparagine synthase
M8961_RS19025	COG1113	amino acid transport
M8961_RS19030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M8961_RS19035	COG2267	carboxylic ester hydrolase activity
M8961_RS19045	COG0584	glycerophosphoryl diester phosphodiesterase
M8961_RS19055	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M8961_RS19060	COG1242	4 iron, 4 sulfur cluster binding
M8961_RS19065	COG0477	Major facilitator Superfamily
M8961_RS19095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS19100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8961_RS19115	COG0516	GMP reductase activity
M8961_RS19115	COG0517	IMP dehydrogenase activity
M8961_RS19120	COG1686	Belongs to the peptidase S11 family
M8961_RS19140	COG1929	Belongs to the glycerate kinase type-1 family
M8961_RS19150	COG1428	Deoxynucleoside kinase
M8961_RS19155	COG1428	Deoxynucleoside kinase
M8961_RS19160	COG1388	LysM domain
M8961_RS19160	COG3858	chitin binding
M8961_RS19165	COG1335	isochorismatase
M8961_RS19170	COG0590	tRNA wobble adenosine to inosine editing
M8961_RS19180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M8961_RS19185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection