locus-tag	class	description
HC661_RS00010	COG0592	DNA-directed DNA polymerase activity
HC661_RS00015	COG2501	S4 domain
HC661_RS00030	COG0187	DNA topoisomerase II activity
HC661_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC661_RS00070	COG0517	IMP dehydrogenase activity
HC661_RS00070	COG0516	GMP reductase activity
HC661_RS00075	COG1686	Belongs to the peptidase S11 family
HC661_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
HC661_RS00105	COG1428	Deoxynucleoside kinase
HC661_RS00110	COG1428	Deoxynucleoside kinase
HC661_RS00115	COG3858	chitin binding
HC661_RS00115	COG1388	LysM domain
HC661_RS00120	COG1335	isochorismatase
HC661_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HC661_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC661_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC661_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC661_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC661_RS00195	COG3853	Toxic anion resistance protein (TelA)
HC661_RS00200	COG1982	Orn Lys Arg decarboxylase major
HC661_RS00210	COG3870	Protein conserved in bacteria
HC661_RS00215	COG1728	Protein conserved in bacteria
HC661_RS00220	COG0470	DNA polymerase III
HC661_RS00225	COG1774	PSP1 C-terminal conserved region
HC661_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC661_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC661_RS00250	COG2002	toxin-antitoxin pair type II binding
HC661_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC661_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC661_RS00260	COG0084	hydrolase, TatD family'
HC661_RS00265	COG3584	3D domain protein
HC661_RS00265	COG3583	domain protein
HC661_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC661_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC661_RS00285	COG4466	Protein conserved in bacteria
HC661_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC661_RS00305	COG0251	oxidation-reduction process
HC661_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC661_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC661_RS00345	COG2002	toxin-antitoxin pair type II binding
HC661_RS00350	COG2244	polysaccharide biosynthetic process
HC661_RS00355	COG3956	TIGRFAM MazG family protein
HC661_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC661_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC661_RS00380	COG1098	S1 RNA binding domain
HC661_RS00395	COG2208	phosphoserine phosphatase activity
HC661_RS00400	COG2304	oxidoreductase activity
HC661_RS00405	COG0515	serine threonine protein kinase
HC661_RS00410	COG0037	tRNA processing
HC661_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC661_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC661_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC661_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC661_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HC661_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC661_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC661_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC661_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC661_RS00475	COG1396	sequence-specific DNA binding
HC661_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC661_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC661_RS00565	COG4463	regulation of RNA biosynthetic process
HC661_RS00570	COG3880	PFAM UvrB UvrC protein
HC661_RS00580	COG0542	response to heat
HC661_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC661_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC661_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HC661_RS00615	COG1045	serine acetyltransferase
HC661_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC661_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC661_RS00635	COG3688	RNA-binding protein containing a PIN domain
HC661_RS00640	COG1595	DNA-templated transcription, initiation
HC661_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC661_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HC661_RS00680	COG2813	Specifically methylates the guanine in position
HC661_RS00695	COG1358	cellular component organization or biogenesis
HC661_RS00720	COG0596	Alpha beta hydrolase
HC661_RS00830	COG0201	protein transport
HC661_RS00840	COG0024	Methionine aminopeptidase
HC661_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC661_RS00880	COG1122	ATPase activity
HC661_RS00885	COG1122	ATPase activity
HC661_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC661_RS00910	COG2226	methyltransferase
HC661_RS00915	COG2318	DinB family
HC661_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS00930	COG0489	protein tyrosine kinase activity
HC661_RS00940	COG2194	sulfuric ester hydrolase activity
HC661_RS00945	COG0726	polysaccharide deacetylase
HC661_RS01040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC661_RS01055	COG0659	secondary active sulfate transmembrane transporter activity
HC661_RS01060	COG0385	Bile acid
HC661_RS01065	COG2819	hydrolase of the alpha beta superfamily
HC661_RS01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS01075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS01080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS01085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS01085	COG2207	Transcriptional regulator
HC661_RS01090	COG3876	Protein conserved in bacteria
HC661_RS01095	COG1472	Belongs to the glycosyl hydrolase 3 family
HC661_RS01100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC661_RS01105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS01105	COG1263	PTS System
HC661_RS01115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS01120	COG1683	Conserved Protein
HC661_RS01150	COG1595	DNA-templated transcription, initiation
HC661_RS01155	COG5662	AntiSigma factor
HC661_RS01160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC661_RS01165	COG4856	YbbR-like protein
HC661_RS01220	COG1346	cytolysis
HC661_RS01225	COG1380	Effector of murein hydrolase LrgA
HC661_RS01230	COG1846	Transcriptional regulator
HC661_RS01235	COG1113	amino acid transport
HC661_RS01260	COG2197	response regulator
HC661_RS01270	COG1011	Hydrolase
HC661_RS01275	COG1113	amino acid transport
HC661_RS01280	COG1846	Transcriptional regulator
HC661_RS01285	COG1380	Effector of murein hydrolase LrgA
HC661_RS01290	COG1346	cytolysis
HC661_RS01335	COG1346	cytolysis
HC661_RS01340	COG1380	Effector of murein hydrolase LrgA
HC661_RS01345	COG1846	Transcriptional regulator
HC661_RS01350	COG1113	amino acid transport
HC661_RS01355	COG1011	Hydrolase
HC661_RS01360	COG4585	Histidine kinase
HC661_RS01365	COG2197	response regulator
HC661_RS01370	COG1131	(ABC) transporter
HC661_RS01410	COG0531	amino acid
HC661_RS01415	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC661_RS01430	COG0584	glycerophosphoryl diester phosphodiesterase
HC661_RS01435	COG2271	Major facilitator Superfamily
HC661_RS01445	COG2368	4-hydroxyphenylacetate
HC661_RS01455	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS01470	COG0371	Dehydrogenase
HC661_RS01480	COG1183	phosphatidylcholine synthase activity
HC661_RS01485	COG0586	Pfam SNARE associated Golgi protein
HC661_RS01490	COG0688	phosphatidylethanolamine metabolic process
HC661_RS01505	COG1301	dicarboxylic acid transport
HC661_RS01510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC661_RS01520	COG2040	homocysteine
HC661_RS01525	COG1115	amino acid carrier protein
HC661_RS01530	COG2066	Belongs to the glutaminase family
HC661_RS01535	COG4191	Histidine kinase
HC661_RS01540	COG0784	Response regulator, receiver
HC661_RS01560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC661_RS01565	COG0778	Nitroreductase
HC661_RS01570	COG0346	lactoylglutathione lyase activity
HC661_RS01575	COG2259	Doxx family
HC661_RS01580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS01590	COG3773	Cell wall hydrolase
HC661_RS01595	COG3540	Alkaline phosphatase
HC661_RS01600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC661_RS01605	COG0805	protein transport
HC661_RS01615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC661_RS01620	COG0477	Major facilitator Superfamily
HC661_RS01625	COG1309	transcriptional regulator
HC661_RS01630	COG0252	asparaginase activity
HC661_RS01635	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC661_RS01640	COG3012	SEC-C Motif Domain Protein
HC661_RS01640	COG1405	negative regulation of cell septum assembly
HC661_RS01645	COG0667	Aldo Keto reductase
HC661_RS01655	COG1595	DNA-templated transcription, initiation
HC661_RS01660	COG1595	DNA-templated transcription, initiation
HC661_RS01665	COG1876	peptidase activity
HC661_RS01670	COG0457	Tetratricopeptide repeat
HC661_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS01700	COG0366	Alpha amylase catalytic
HC661_RS01705	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC661_RS01710	COG1121	(ABC) transporter
HC661_RS01715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC661_RS01720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS01725	COG2310	stress, protein
HC661_RS01730	COG2310	stress, protein
HC661_RS01735	COG2310	stress, protein
HC661_RS01740	COG0861	Integral membrane protein TerC family
HC661_RS01750	COG3853	Toxic anion resistance protein (TelA)
HC661_RS01755	COG0477	Major facilitator Superfamily
HC661_RS01760	COG0517	IMP dehydrogenase activity
HC661_RS01760	COG4175	Glycine betaine
HC661_RS01765	COG4176	ABC-type proline glycine betaine transport system permease component
HC661_RS01770	COG2113	Glycine betaine
HC661_RS01775	COG1473	amidohydrolase
HC661_RS01780	COG1288	antiporter activity
HC661_RS01790	COG0366	Alpha amylase catalytic
HC661_RS01800	COG2814	Major facilitator Superfamily
HC661_RS01805	COG1846	Transcriptional regulator
HC661_RS01810	COG1280	lysine exporter protein (LysE YggA)
HC661_RS01815	COG3403	YqcI/YcgG family
HC661_RS01820	COG1113	amino acid transport
HC661_RS01825	COG3665	Urea carboxylase-associated protein
HC661_RS01840	COG1660	Displays ATPase and GTPase activities
HC661_RS01845	COG1082	Xylose isomerase domain protein TIM barrel
HC661_RS01850	COG2271	Major facilitator Superfamily
HC661_RS01855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC661_RS01860	COG3458	cephalosporin-C deacetylase activity
HC661_RS01865	COG3541	Predicted nucleotidyltransferase
HC661_RS01870	COG0506	proline dehydrogenase activity
HC661_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS01880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC661_RS01885	COG2508	Transcriptional regulator
HC661_RS01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC661_RS01895	COG1587	Uroporphyrinogen-III synthase
HC661_RS01900	COG2146	nitrite reductase [NAD(P)H] activity
HC661_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC661_RS01910	COG0243	molybdopterin cofactor binding
HC661_RS01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC661_RS01920	COG2223	nitrite transmembrane transporter activity
HC661_RS01925	COG0523	cobalamin synthesis protein
HC661_RS01930	COG1063	alcohol dehydrogenase
HC661_RS01935	COG1714	RDD family
HC661_RS01945	COG2723	6-phospho-beta-galactosidase activity
HC661_RS01955	COG3209	COG3209 Rhs family protein
HC661_RS01960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC661_RS01965	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC661_RS01970	COG1733	regulation of RNA biosynthetic process
HC661_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS01990	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC661_RS02005	COG0697	spore germination
HC661_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS02020	COG2364	Membrane
HC661_RS02025	COG1126	abc transporter atp-binding protein
HC661_RS02030	COG0765	amino acid transport
HC661_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS02040	COG0583	DNA-binding transcription factor activity
HC661_RS02045	COG0163	prenyltransferase activity
HC661_RS02050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC661_RS02065	COG3104	oligopeptide transport
HC661_RS02070	COG5434	Belongs to the glycosyl hydrolase 28 family
HC661_RS02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC661_RS02095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS02100	COG0456	acetyltransferase
HC661_RS02105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS02110	COG0765	amino acid transport
HC661_RS02115	COG1126	abc transporter atp-binding protein
HC661_RS02120	COG1473	amidohydrolase
HC661_RS02125	COG2079	MmgE PrpD family protein
HC661_RS02130	COG1136	(ABC) transporter
HC661_RS02135	COG0577	efflux transmembrane transporter activity
HC661_RS02140	COG0745	RESPONSE REGULATOR receiver
HC661_RS02145	COG3850	Histidine kinase
HC661_RS02145	COG5002	protein histidine kinase activity
HC661_RS02150	COG0457	Tetratricopeptide repeat
HC661_RS02165	COG0527	aspartate kinase activity
HC661_RS02170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS02175	COG4605	iron ion homeostasis
HC661_RS02180	COG4604	ABC transporter, ATP-binding protein
HC661_RS02185	COG4607	ABC-type enterochelin transport system periplasmic component
HC661_RS02190	COG2814	Major facilitator Superfamily
HC661_RS02195	COG1309	transcriptional regulator
HC661_RS02200	COG0778	Nitroreductase
HC661_RS02205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC661_RS02210	COG0640	Transcriptional regulator
HC661_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC661_RS02225	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS02230	COG4975	Glucose uptake
HC661_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS02240	COG4549	nuclear export factor GLE1
HC661_RS02245	COG2372	response to copper ion
HC661_RS02245	COG1276	copper resistance
HC661_RS02250	COG1349	DNA-binding transcription factor activity
HC661_RS02260	COG2213	PTS system mannitol-specific
HC661_RS02265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS02275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC661_RS02285	COG0561	phosphatase activity
HC661_RS02295	COG1914	H( )-stimulated, divalent metal cation uptake system
HC661_RS02305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC661_RS02310	COG1984	allophanate hydrolase subunit 2
HC661_RS02315	COG1414	Transcriptional regulator
HC661_RS02320	COG2755	lipolytic protein G-D-S-L family
HC661_RS02330	COG2329	Antibiotic biosynthesis monooxygenase
HC661_RS02335	COG0768	penicillin binding
HC661_RS02340	COG4989	oxidoreductase activity
HC661_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS02360	COG1917	Cupin 2, conserved barrel domain protein
HC661_RS02365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS02370	COG3871	stress protein (general stress protein 26)
HC661_RS02380	COG2814	Major facilitator Superfamily
HC661_RS02385	COG1522	sequence-specific DNA binding
HC661_RS02390	COG0551	DNA topoisomerase type I activity
HC661_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC661_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC661_RS02400	COG3706	GGDEF domain
HC661_RS02405	COG5298	Protein conserved in bacteria
HC661_RS02410	COG1215	transferase activity, transferring glycosyl groups
HC661_RS02420	COG0531	amino acid
HC661_RS02425	COG0494	nUDIX hydrolase
HC661_RS02430	COG0028	Belongs to the TPP enzyme family
HC661_RS02455	COG1914	H( )-stimulated, divalent metal cation uptake system
HC661_RS02475	COG2076	Multidrug Resistance protein
HC661_RS02480	COG2217	Heavy metal translocating P-type atpase
HC661_RS02485	COG3729	General stress protein
HC661_RS02490	COG0662	Cupin 2, conserved barrel domain protein
HC661_RS02495	COG2329	Antibiotic biosynthesis monooxygenase
HC661_RS02500	COG3546	catalase activity
HC661_RS02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC661_RS02510	COG3290	protein histidine kinase activity
HC661_RS02515	COG4565	transcriptional regulatory protein
HC661_RS02520	COG1301	dicarboxylic acid transport
HC661_RS02525	COG0628	permease
HC661_RS02530	COG1131	(ABC) transporter
HC661_RS02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC661_RS02545	COG1960	acyl-CoA dehydrogenase activity
HC661_RS02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC661_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC661_RS02580	COG0513	Belongs to the DEAD box helicase family
HC661_RS02585	COG3402	PFAM membrane-flanked domain
HC661_RS02590	COG3428	Bacterial PH domain
HC661_RS02595	COG0705	Rhomboid family
HC661_RS02605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC661_RS02610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC661_RS02615	COG0864	Transcriptional regulator
HC661_RS02620	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC661_RS02625	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS02635	COG2172	sigma factor antagonist activity
HC661_RS02640	COG2208	phosphoserine phosphatase activity
HC661_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS02655	COG1191	sigma factor activity
HC661_RS02660	COG2208	phosphoserine phosphatase activity
HC661_RS02665	COG2183	response to ionizing radiation
HC661_RS02715	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC661_RS02725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC661_RS02730	COG1522	sequence-specific DNA binding
HC661_RS02745	COG0477	Major facilitator Superfamily
HC661_RS02760	COG2030	dehydratase
HC661_RS02775	COG1959	2 iron, 2 sulfur cluster binding
HC661_RS02780	COG2910	NAD(P)H-binding
HC661_RS02785	COG1278	Cold shock
HC661_RS02790	COG1329	Transcriptional regulator
HC661_RS02810	COG3621	Patatin-like phospholipase
HC661_RS02820	COG0662	Cupin 2, conserved barrel domain protein
HC661_RS02835	COG0277	FAD linked oxidase domain protein
HC661_RS02860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC661_RS02895	COG0351	phosphomethylpyrimidine kinase
HC661_RS02910	COG1064	alcohol dehydrogenase
HC661_RS02915	COG0789	Transcriptional regulator
HC661_RS02925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS02940	COG2814	Major facilitator Superfamily
HC661_RS02945	COG1309	transcriptional regulator
HC661_RS02950	COG0697	spore germination
HC661_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS02960	COG5577	PFAM Coat F domain
HC661_RS02970	COG1063	alcohol dehydrogenase
HC661_RS02975	COG5577	PFAM Coat F domain
HC661_RS02985	COG4585	Histidine kinase
HC661_RS02990	COG2197	response regulator
HC661_RS02995	COG2409	Drug exporters of the RND superfamily
HC661_RS03000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC661_RS03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS03015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS03025	COG2814	Major facilitator Superfamily
HC661_RS03030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC661_RS03045	COG0456	acetyltransferase
HC661_RS03055	COG1051	belongs to the nudix hydrolase family
HC661_RS03065	COG0473	3-isopropylmalate dehydrogenase activity
HC661_RS03070	COG1802	Transcriptional regulator
HC661_RS03075	COG1819	glycosyl
HC661_RS03090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC661_RS03100	COG1388	LysM domain
HC661_RS03105	COG2814	Major facilitator Superfamily
HC661_RS03110	COG2188	Transcriptional regulator
HC661_RS03115	COG2186	Transcriptional regulator
HC661_RS03120	COG2807	transmembrane transport
HC661_RS03130	COG2076	Multidrug Resistance protein
HC661_RS03135	COG1309	transcriptional regulator
HC661_RS03140	COG0531	amino acid
HC661_RS03150	COG3832	glyoxalase III activity
HC661_RS03155	COG0604	alcohol dehydrogenase
HC661_RS03160	COG2814	Major facilitator Superfamily
HC661_RS03200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC661_RS03205	COG0802	atpase or kinase
HC661_RS03210	COG1214	PFAM Peptidase M22, glycoprotease
HC661_RS03215	COG0456	acetyltransferase
HC661_RS03220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC661_RS03225	COG0488	(ABC) transporter
HC661_RS03240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC661_RS03245	COG0805	protein transport
HC661_RS03255	COG1266	CAAX protease self-immunity
HC661_RS03275	COG0457	Tetratricopeptide repeat
HC661_RS03280	COG1063	alcohol dehydrogenase
HC661_RS03285	COG2211	Major facilitator Superfamily
HC661_RS03290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC661_RS03300	COG1842	Phage shock protein A
HC661_RS03305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC661_RS03310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HC661_RS03315	COG4260	virion core protein, lumpy skin disease virus
HC661_RS03320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC661_RS03320	COG2755	lipolytic protein G-D-S-L family
HC661_RS03330	COG1595	DNA-templated transcription, initiation
HC661_RS03335	COG1063	alcohol dehydrogenase
HC661_RS03340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC661_RS03345	COG0823	Involved in the tonB-independent uptake of proteins
HC661_RS03365	COG1113	amino acid transport
HC661_RS03370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC661_RS03375	COG0714	Associated with various cellular activities
HC661_RS03380	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC661_RS03385	COG1305	Transglutaminase-like
HC661_RS03410	COG2252	PERMEase
HC661_RS03415	COG3064	Membrane
HC661_RS03435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC661_RS03440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC661_RS03445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC661_RS03450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC661_RS03455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC661_RS03470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC661_RS03480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC661_RS03485	COG0138	bifunctional purine biosynthesis protein purh
HC661_RS03490	COG0151	Belongs to the GarS family
HC661_RS03500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC661_RS03505	COG1470	cell adhesion involved in biofilm formation
HC661_RS03510	COG4496	protein, YerC YecD
HC661_RS03515	COG0069	glutamate synthase activity
HC661_RS03525	COG0210	DNA helicase
HC661_RS03535	COG4851	CamS sex pheromone cAM373 precursor
HC661_RS03540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC661_RS03545	COG1285	pathogenesis
HC661_RS03550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC661_RS03570	COG1309	transcriptional regulator
HC661_RS03575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC661_RS03580	COG1597	lipid kinase activity
HC661_RS03585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC661_RS03595	COG1131	(ABC) transporter
HC661_RS03615	COG5444	nuclease activity
HC661_RS03645	COG3546	catalase activity
HC661_RS03650	COG0454	-acetyltransferase
HC661_RS03660	COG2323	membrane
HC661_RS03665	COG2329	Antibiotic biosynthesis monooxygenase
HC661_RS03670	COG0346	lactoylglutathione lyase activity
HC661_RS03675	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS03680	COG5583	Uncharacterized small protein (DUF2292)
HC661_RS03685	COG0196	riboflavin kinase activity
HC661_RS03690	COG0670	Belongs to the BI1 family
HC661_RS03700	COG1846	Transcriptional regulator
HC661_RS03705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC661_RS03715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC661_RS03715	COG2124	cytochrome p450
HC661_RS03730	COG1131	(ABC) transporter
HC661_RS03740	COG1368	sulfuric ester hydrolase activity
HC661_RS03745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC661_RS03750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS03755	COG1442	glycosyl transferase family 8
HC661_RS03760	COG1216	Glycosyl transferase, family 2
HC661_RS03765	COG1442	glycosyl transferase family 8
HC661_RS03770	COG2223	nitrite transmembrane transporter activity
HC661_RS03775	COG0531	amino acid
HC661_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS03785	COG0840	transmembrane signaling receptor activity
HC661_RS03790	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS03795	COG0463	Glycosyl transferase, family 2
HC661_RS03795	COG0457	Tetratricopeptide repeat
HC661_RS03800	COG0488	(ABC) transporter
HC661_RS03805	COG0789	Transcriptional regulator
HC661_RS03810	COG2814	Major facilitator Superfamily
HC661_RS03815	COG0488	(ABC) transporter
HC661_RS03820	COG0513	Belongs to the DEAD box helicase family
HC661_RS03825	COG0456	acetyltransferase
HC661_RS03830	COG2130	NADP-dependent
HC661_RS03845	COG3866	Pectate lyase
HC661_RS03850	COG0471	metal ion transport
HC661_RS03865	COG3290	protein histidine kinase activity
HC661_RS03870	COG4565	transcriptional regulatory protein
HC661_RS03875	COG3181	Tripartite tricarboxylate transporter family receptor
HC661_RS03880	COG2851	Citrate transporter
HC661_RS03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS03890	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC661_RS03900	COG2258	MOSC domain
HC661_RS03920	COG0024	Methionine aminopeptidase
HC661_RS03925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS03925	COG1263	PTS System
HC661_RS03935	COG1368	sulfuric ester hydrolase activity
HC661_RS03945	COG0071	Belongs to the small heat shock protein (HSP20) family
HC661_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS03960	COG1263	PTS System
HC661_RS03965	COG0366	Alpha amylase catalytic
HC661_RS03970	COG2188	Transcriptional regulator
HC661_RS03975	COG0778	Nitroreductase
HC661_RS03990	COG0737	Belongs to the 5'-nucleotidase family
HC661_RS03995	COG0693	protein deglycase activity
HC661_RS04000	COG1609	Transcriptional regulator
HC661_RS04015	COG2814	Major facilitator Superfamily
HC661_RS04025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC661_RS04030	COG4980	gas vesicle protein
HC661_RS04035	COG1295	ribonuclease BN
HC661_RS04040	COG0477	Major facilitator Superfamily
HC661_RS04045	COG0387	Pfam Sodium calcium exchanger
HC661_RS04055	COG0668	transmembrane transport
HC661_RS04060	COG0535	radical SAM domain protein
HC661_RS04070	COG0726	polysaccharide deacetylase
HC661_RS04075	COG2084	Dehydrogenase
HC661_RS04085	COG0598	Magnesium transport protein CorA
HC661_RS04090	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC661_RS04095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC661_RS04105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC661_RS04115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC661_RS04120	COG0022	dehydrogenase e1 component
HC661_RS04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC661_RS04130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC661_RS04135	COG3284	Transcriptional regulator
HC661_RS04145	COG1486	melibiose metabolic process
HC661_RS04150	COG1737	Transcriptional regulator
HC661_RS04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS04155	COG1263	PTS System
HC661_RS04160	COG1132	(ABC) transporter
HC661_RS04165	COG1132	(ABC) transporter
HC661_RS04170	COG2259	Doxx family
HC661_RS04175	COG2514	catechol 2,3-dioxygenase activity
HC661_RS04185	COG1695	Transcriptional regulator
HC661_RS04190	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC661_RS04195	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC661_RS04205	COG3848	Pyruvate phosphate dikinase
HC661_RS04205	COG0574	Belongs to the PEP-utilizing enzyme family
HC661_RS04210	COG2732	(Barnase) inhibitor
HC661_RS04215	COG2318	DinB family
HC661_RS04220	COG2814	Major facilitator Superfamily
HC661_RS04225	COG1846	Transcriptional regulator
HC661_RS04230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC661_RS04230	COG0392	lysyltransferase activity
HC661_RS04235	COG0384	phenazine biosynthesis protein PhzF
HC661_RS04240	COG0778	Nitroreductase
HC661_RS04255	COG1090	epimerase
HC661_RS04270	COG2814	Major facilitator Superfamily
HC661_RS04280	COG3591	Belongs to the peptidase S1B family
HC661_RS04295	COG3103	Sh3 type 3 domain protein
HC661_RS04300	COG5658	integral membrane protein
HC661_RS04305	COG0596	Alpha beta hydrolase
HC661_RS04310	COG0463	Glycosyl transferase, family 2
HC661_RS04320	COG1988	membrane-bound metal-dependent
HC661_RS04325	COG1194	a g-specific adenine glycosylase
HC661_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS04355	COG1132	(ABC) transporter
HC661_RS04360	COG4129	membrane
HC661_RS04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC661_RS04375	COG0735	belongs to the Fur family
HC661_RS04505	COG3340	Belongs to the peptidase S51 family
HC661_RS04515	COG0277	FAD linked oxidase domain protein
HC661_RS04525	COG0747	negative chemotaxis
HC661_RS04530	COG0601	transmembrane transport
HC661_RS04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC661_RS04540	COG0444	Belongs to the ABC transporter superfamily
HC661_RS04545	COG4608	Belongs to the ABC transporter superfamily
HC661_RS04550	COG0753	catalase activity
HC661_RS04560	COG1116	anion transmembrane transporter activity
HC661_RS04565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC661_RS04570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC661_RS04590	COG1476	TRANSCRIPTIONal
HC661_RS04600	COG3382	B3 4 domain protein
HC661_RS04605	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC661_RS04615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC661_RS04620	COG0789	Transcriptional regulator
HC661_RS04625	COG1664	Polymer-forming cytoskeletal
HC661_RS04630	COG1664	Polymer-forming cytoskeletal
HC661_RS04635	COG2766	serine protein kinase
HC661_RS04645	COG1846	Transcriptional regulator
HC661_RS04650	COG1566	PFAM secretion protein HlyD family protein
HC661_RS04660	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC661_RS04675	COG1725	Transcriptional regulator
HC661_RS04680	COG1131	(ABC) transporter
HC661_RS04685	COG1131	(ABC) transporter
HC661_RS04690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC661_RS04695	COG1278	Cold shock
HC661_RS04700	COG1464	Belongs to the NlpA lipoprotein family
HC661_RS04705	COG3706	GGDEF domain
HC661_RS04710	COG1823	symporter activity
HC661_RS04730	COG5577	PFAM Coat F domain
HC661_RS04735	COG0737	Belongs to the 5'-nucleotidase family
HC661_RS04735	COG4085	toxin activity
HC661_RS04735	COG1525	nuclease
HC661_RS04745	COG0564	pseudouridine synthase activity
HC661_RS04755	COG0517	IMP dehydrogenase activity
HC661_RS04760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC661_RS04765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC661_RS04765	COG3153	acetyltransferase
HC661_RS04770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC661_RS04775	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC661_RS04780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC661_RS04790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC661_RS04795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC661_RS04800	COG4585	Histidine kinase
HC661_RS04800	COG2203	Gaf domain
HC661_RS04805	COG2197	response regulator
HC661_RS04810	COG0431	NADPH-dependent FMN reductase
HC661_RS04825	COG0791	NLP P60 protein
HC661_RS04825	COG1388	LysM domain
HC661_RS04830	COG1959	2 iron, 2 sulfur cluster binding
HC661_RS04835	COG0668	transmembrane transport
HC661_RS04840	COG2719	SpoVR family
HC661_RS04845	COG1785	Belongs to the alkaline phosphatase family
HC661_RS04850	COG1388	LysM domain
HC661_RS04850	COG0791	NLP P60 protein
HC661_RS04855	COG0583	DNA-binding transcription factor activity
HC661_RS04860	COG0372	Belongs to the citrate synthase family
HC661_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS04870	COG0531	amino acid
HC661_RS04875	COG0733	neurotransmitter:sodium symporter activity
HC661_RS04890	COG1595	DNA-templated transcription, initiation
HC661_RS04895	COG0204	Acyl-transferase
HC661_RS04900	COG1253	flavin adenine dinucleotide binding
HC661_RS04905	COG0789	Transcriptional regulator
HC661_RS04910	COG0436	Aminotransferase
HC661_RS04915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC661_RS04920	COG1253	flavin adenine dinucleotide binding
HC661_RS04925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC661_RS04930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC661_RS04935	COG0584	glycerophosphoryl diester phosphodiesterase
HC661_RS04945	COG0668	transmembrane transport
HC661_RS04950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC661_RS04955	COG0726	polysaccharide deacetylase
HC661_RS04960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC661_RS04965	COG3226	Transcriptional regulator
HC661_RS04975	COG0589	response to stress
HC661_RS04980	COG1132	(ABC) transporter
HC661_RS04985	COG1132	(ABC) transporter
HC661_RS04990	COG0702	epimerase
HC661_RS05010	COG0189	ligase activity
HC661_RS05025	COG4335	DNA alkylation repair
HC661_RS05030	COG0561	phosphatase activity
HC661_RS05035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC661_RS05045	COG0475	glutathione-regulated potassium exporter activity
HC661_RS05050	COG0490	domain, Protein
HC661_RS05060	COG1024	Enoyl-CoA hydratase
HC661_RS05070	COG4152	abc transporter atp-binding protein
HC661_RS05075	COG1668	transmembrane transport
HC661_RS05080	COG0420	3'-5' exonuclease activity
HC661_RS05085	COG4717	serine-type aminopeptidase activity
HC661_RS05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC661_RS05135	COG4980	gas vesicle protein
HC661_RS05150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC661_RS05155	COG0537	adenosine 5'-monophosphoramidase activity
HC661_RS05160	COG1131	(ABC) transporter
HC661_RS05165	COG4473	ABC transporter
HC661_RS05175	COG1473	amidohydrolase
HC661_RS05180	COG3069	C4-dicarboxylate transmembrane transporter activity
HC661_RS05185	COG2329	Antibiotic biosynthesis monooxygenase
HC661_RS05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC661_RS05210	COG1309	transcriptional regulator
HC661_RS05215	COG1511	domain protein
HC661_RS05220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC661_RS05230	COG1363	Peptidase, m42
HC661_RS05235	COG1301	dicarboxylic acid transport
HC661_RS05245	COG1234	tRNA 3'-trailer cleavage
HC661_RS05250	COG0095	Lipoate-protein ligase
HC661_RS05255	COG0702	epimerase
HC661_RS05260	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS05270	COG0501	Belongs to the peptidase M48B family
HC661_RS05275	COG1404	Belongs to the peptidase S8 family
HC661_RS05285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC661_RS05290	COG0406	alpha-ribazole phosphatase activity
HC661_RS05295	COG0183	Belongs to the thiolase family
HC661_RS05300	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS05305	COG1268	BioY protein
HC661_RS05315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC661_RS05315	COG0723	plastoquinol--plastocyanin reductase activity
HC661_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS05330	COG4903	ComK protein
HC661_RS05340	COG5646	InterPro IPR014922
HC661_RS05365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC661_RS05380	COG0398	Pfam SNARE associated Golgi protein
HC661_RS05385	COG0681	Belongs to the peptidase S26 family
HC661_RS05390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC661_RS05395	COG1846	Transcriptional regulator
HC661_RS05400	COG3180	Ammonia monooxygenase
HC661_RS05405	COG2814	Major facilitator Superfamily
HC661_RS05415	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC661_RS05420	COG2323	membrane
HC661_RS05435	COG0420	3'-5' exonuclease activity
HC661_RS05440	COG0419	ATPase involved in DNA repair
HC661_RS05445	COG1403	HNH endonuclease
HC661_RS05485	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC661_RS05505	COG0367	asparagine synthase
HC661_RS05510	COG1562	ergosterol biosynthetic process
HC661_RS05515	COG0534	Mate efflux family protein
HC661_RS05520	COG1917	Cupin 2, conserved barrel domain protein
HC661_RS05520	COG2207	Transcriptional regulator
HC661_RS05525	COG2318	DinB family
HC661_RS05530	COG1357	PFAM Pentapeptide repeats (8 copies)
HC661_RS05535	COG2153	protein acetylation
HC661_RS05540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC661_RS05540	COG0646	methionine synthase
HC661_RS05550	COG2996	Protein conserved in bacteria
HC661_RS05560	COG0840	transmembrane signaling receptor activity
HC661_RS05565	COG2124	cytochrome p450
HC661_RS05575	COG1307	EDD domain protein, DegV family
HC661_RS05580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS05600	COG0561	phosphatase activity
HC661_RS05605	COG1073	alpha beta
HC661_RS05610	COG2151	metal-sulfur cluster biosynthetic enzyme
HC661_RS05620	COG0277	FAD linked oxidase domain protein
HC661_RS05625	COG2271	Major facilitator Superfamily
HC661_RS05635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC661_RS05645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC661_RS05650	COG0505	Belongs to the CarA family
HC661_RS05655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC661_RS05660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC661_RS05675	COG2267	carboxylic ester hydrolase activity
HC661_RS05700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC661_RS05705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC661_RS05710	COG5504	Zn-dependent protease
HC661_RS05715	COG0444	Belongs to the ABC transporter superfamily
HC661_RS05720	COG4608	Belongs to the ABC transporter superfamily
HC661_RS05730	COG0601	transmembrane transport
HC661_RS05735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC661_RS05745	COG0180	Tryptophanyl-tRNA synthetase
HC661_RS05750	COG4166	transmembrane transport
HC661_RS05755	COG0601	transmembrane transport
HC661_RS05760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC661_RS05765	COG0444	Belongs to the ABC transporter superfamily
HC661_RS05770	COG4608	Belongs to the ABC transporter superfamily
HC661_RS05780	COG0456	acetyltransferase
HC661_RS05785	COG1393	Belongs to the ArsC family
HC661_RS05790	COG0861	Integral membrane protein TerC family
HC661_RS05795	COG4862	establishment of competence for transformation
HC661_RS05800	COG4469	Competence protein
HC661_RS05805	COG1164	Oligoendopeptidase f
HC661_RS05820	COG2346	COG2346, Truncated hemoglobins
HC661_RS05825	COG0741	lytic transglycosylase activity
HC661_RS05830	COG4116	CYTH
HC661_RS05840	COG2357	RelA SpoT domain protein
HC661_RS05845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC661_RS05850	COG0564	pseudouridine synthase activity
HC661_RS05860	COG0569	domain protein
HC661_RS05860	COG0475	glutathione-regulated potassium exporter activity
HC661_RS05865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC661_RS05870	COG0352	thiamine-phosphate diphosphorylase activity
HC661_RS05875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC661_RS05880	COG2104	thiamine diphosphate biosynthetic process
HC661_RS05890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC661_RS05895	COG0351	phosphomethylpyrimidine kinase
HC661_RS05900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC661_RS05955	COG0210	DNA helicase
HC661_RS05975	COG1131	(ABC) transporter
HC661_RS05985	COG2153	protein acetylation
HC661_RS05995	COG2382	esterase
HC661_RS06000	COG0626	cystathionine gamma-synthase activity
HC661_RS06005	COG0626	cystathionine gamma-synthase activity
HC661_RS06025	COG4974	Belongs to the 'phage' integrase family
HC661_RS06240	COG0135	phosphoribosylanthranilate isomerase activity
HC661_RS06250	COG2367	Beta-lactamase
HC661_RS06255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC661_RS06260	COG2814	Major facilitator Superfamily
HC661_RS06265	COG1846	Transcriptional regulator
HC661_RS06275	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC661_RS06280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC661_RS06285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC661_RS06290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS06290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS06295	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC661_RS06305	COG1349	DNA-binding transcription factor activity
HC661_RS06325	COG1285	pathogenesis
HC661_RS06340	COG2205	protein histidine kinase activity
HC661_RS06350	COG3383	formate dehydrogenase (NAD+) activity
HC661_RS06355	COG2427	Protein of unknown function (DUF1641)
HC661_RS06360	COG2124	cytochrome p450
HC661_RS06365	COG1819	glycosyl
HC661_RS06375	COG1587	Uroporphyrinogen-III synthase
HC661_RS06380	COG0390	transport system, permease component
HC661_RS06385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC661_RS06390	COG0697	spore germination
HC661_RS06395	COG4297	protein containing double-stranded beta helix domain
HC661_RS06405	COG1252	NADH dehydrogenase
HC661_RS06415	COG2211	Major facilitator Superfamily
HC661_RS06420	COG1609	Transcriptional regulator
HC661_RS06425	COG0246	Mannitol dehydrogenase
HC661_RS06430	COG2721	sulfolactate sulfo-lyase activity
HC661_RS06435	COG0745	RESPONSE REGULATOR receiver
HC661_RS06440	COG2770	Histidine kinase
HC661_RS06440	COG2205	protein histidine kinase activity
HC661_RS06460	COG0730	response to heat
HC661_RS06465	COG2318	DinB family
HC661_RS06470	COG0457	Tetratricopeptide repeat
HC661_RS06480	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS06480	COG1388	LysM domain
HC661_RS06480	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC661_RS06490	COG4195	phage-related replication protein
HC661_RS06495	COG3546	catalase activity
HC661_RS06500	COG2856	Zn peptidase
HC661_RS06505	COG1396	sequence-specific DNA binding
HC661_RS06520	COG1484	DNA-dependent DNA replication
HC661_RS06540	COG1595	DNA-templated transcription, initiation
HC661_RS06545	COG3728	DNA packaging
HC661_RS06545	COG5484	DNA packaging
HC661_RS06550	COG1783	phage Terminase large subunit
HC661_RS06555	COG5518	Phage portal protein
HC661_RS06560	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC661_RS06565	COG4653	Phage capsid family
HC661_RS06615	COG3953	SLT domain
HC661_RS06615	COG3953	SLT domain
HC661_RS06615	COG5412	phage tail tape measure protein
HC661_RS06615	COG5412	phage tail tape measure protein
HC661_RS06615	COG5412	phage tail tape measure protein
HC661_RS06615	COG3953	SLT domain
HC661_RS06620	COG1652	LysM domain
HC661_RS06625	COG4193	domain, Protein
HC661_RS06635	COG3628	GPW Gp25 family protein
HC661_RS06640	COG3299	homolog of phage Mu protein gp47
HC661_RS06645	COG3778	Protein conserved in bacteria
HC661_RS06685	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS06685	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC661_RS06700	COG0306	phosphate transporter
HC661_RS06705	COG1392	Phosphate transport regulator
HC661_RS06710	COG0531	amino acid
HC661_RS06715	COG0346	lactoylglutathione lyase activity
HC661_RS06720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC661_RS06725	COG0463	Glycosyl transferase, family 2
HC661_RS06740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC661_RS06745	COG0477	Major facilitator Superfamily
HC661_RS06750	COG2362	D-Aminopeptidase
HC661_RS06755	COG0601	transmembrane transport
HC661_RS06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC661_RS06765	COG0444	Belongs to the ABC transporter superfamily
HC661_RS06770	COG4166	transmembrane transport
HC661_RS06775	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC661_RS06780	COG4948	Mandelate Racemase Muconate Lactonizing
HC661_RS06785	COG0791	NLP P60 protein
HC661_RS06790	COG4608	Belongs to the ABC transporter superfamily
HC661_RS06795	COG2706	6-phosphogluconolactonase activity
HC661_RS06800	COG1834	amidinotransferase
HC661_RS06805	COG1607	acyl-coa hydrolase
HC661_RS06810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS06815	COG2076	Multidrug Resistance protein
HC661_RS06820	COG2076	Multidrug Resistance protein
HC661_RS06825	COG0788	formyltetrahydrofolate deformylase activity
HC661_RS06830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC661_RS06840	COG1764	response to oxidative stress
HC661_RS06845	COG1846	Transcriptional regulator
HC661_RS06850	COG1764	response to oxidative stress
HC661_RS06865	COG0457	Tetratricopeptide repeat
HC661_RS06865	COG0463	Glycosyl transferase, family 2
HC661_RS06875	COG2814	Major facilitator Superfamily
HC661_RS06880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC661_RS06890	COG1404	Belongs to the peptidase S8 family
HC661_RS06895	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS06900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC661_RS06905	COG1122	ATPase activity
HC661_RS06910	COG4721	ABC-type cobalt transport system, permease component
HC661_RS06915	COG3858	chitin binding
HC661_RS06915	COG1388	LysM domain
HC661_RS06930	COG2239	Acts as a magnesium transporter
HC661_RS06935	COG0789	Transcriptional regulator
HC661_RS06950	COG1846	Transcriptional regulator
HC661_RS06955	COG0726	polysaccharide deacetylase
HC661_RS06960	COG3285	dna ligase
HC661_RS06960	COG1793	dna ligase
HC661_RS06965	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC661_RS06970	COG0586	Pfam SNARE associated Golgi protein
HC661_RS06975	COG0861	Integral membrane protein TerC family
HC661_RS06980	COG1191	sigma factor activity
HC661_RS07005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC661_RS07010	COG2323	membrane
HC661_RS07020	COG3594	Acyltransferase
HC661_RS07025	COG5002	protein histidine kinase activity
HC661_RS07030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC661_RS07045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC661_RS07050	COG0436	Aminotransferase
HC661_RS07080	COG3852	Histidine kinase
HC661_RS07085	COG1846	Transcriptional regulator
HC661_RS07090	COG1360	Flagellar Motor Protein
HC661_RS07095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC661_RS07100	COG0542	response to heat
HC661_RS07105	COG3949	Membrane
HC661_RS07120	COG0720	synthase
HC661_RS07125	COG0602	queuosine metabolic process
HC661_RS07135	COG1733	regulation of RNA biosynthetic process
HC661_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS07155	COG1388	LysM domain
HC661_RS07160	COG3858	chitin binding
HC661_RS07170	COG4873	Protein conserved in bacteria
HC661_RS07180	COG3773	Cell wall hydrolase
HC661_RS07185	COG2244	polysaccharide biosynthetic process
HC661_RS07190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS07195	COG2217	Heavy metal translocating P-type atpase
HC661_RS07200	COG0006	proline dipeptidase activity
HC661_RS07205	COG1609	Transcriptional regulator
HC661_RS07210	COG3711	transcriptional antiterminator
HC661_RS07215	COG1263	PTS System
HC661_RS07215	COG2190	(PTS) system
HC661_RS07215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS07220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS07225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC661_RS07235	COG1533	DNA photolyase activity
HC661_RS07240	COG0840	transmembrane signaling receptor activity
HC661_RS07245	COG2084	Dehydrogenase
HC661_RS07250	COG2340	Cysteine-rich secretory protein family
HC661_RS07255	COG0768	penicillin binding
HC661_RS07260	COG4191	Histidine kinase
HC661_RS07265	COG0436	Aminotransferase
HC661_RS07275	COG0784	Response regulator, receiver
HC661_RS07275	COG0835	chemotaxis
HC661_RS07285	COG2814	Major facilitator Superfamily
HC661_RS07290	COG1376	ErfK ybiS ycfS ynhG family protein
HC661_RS07295	COG1408	metallophosphoesterase
HC661_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS07310	COG2200	EAL domain
HC661_RS07315	COG4703	Protein of unknown function (DUF1797)
HC661_RS07320	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC661_RS07330	COG0517	IMP dehydrogenase activity
HC661_RS07335	COG0583	DNA-binding transcription factor activity
HC661_RS07340	COG0716	FMN binding
HC661_RS07350	COG0716	FMN binding
HC661_RS07370	COG0668	transmembrane transport
HC661_RS07375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS07395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC661_RS07400	COG0303	'Molybdopterin
HC661_RS07405	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC661_RS07410	COG0314	molybdopterin synthase activity
HC661_RS07415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC661_RS07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC661_RS07430	COG1136	(ABC) transporter
HC661_RS07435	COG0577	efflux transmembrane transporter activity
HC661_RS07440	COG1349	DNA-binding transcription factor activity
HC661_RS07445	COG1105	Belongs to the carbohydrate kinase PfkB family
HC661_RS07450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC661_RS07450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC661_RS07450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS07455	COG0681	Belongs to the peptidase S26 family
HC661_RS07465	COG0488	(ABC) transporter
HC661_RS07470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC661_RS07475	COG2309	aminopeptidase activity
HC661_RS07485	COG1077	Cell shape determining protein MreB Mrl
HC661_RS07490	COG2002	toxin-antitoxin pair type II binding
HC661_RS07495	COG3852	Histidine kinase
HC661_RS07500	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC661_RS07500	COG2105	PFAM AIG2 family protein
HC661_RS07505	COG0569	domain protein
HC661_RS07515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC661_RS07525	COG0561	phosphatase activity
HC661_RS07530	COG0242	peptide deformylase activity
HC661_RS07540	COG0497	DNA recombination
HC661_RS07550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS07550	COG4221	oxidoreductase activity
HC661_RS07550	COG3321	synthase
HC661_RS07555	COG4221	oxidoreductase activity
HC661_RS07555	COG3321	synthase
HC661_RS07555	COG0300	oxidoreductase activity
HC661_RS07555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS07560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS07560	COG3321	synthase
HC661_RS07560	COG4221	oxidoreductase activity
HC661_RS07570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS07570	COG0300	oxidoreductase activity
HC661_RS07570	COG3321	synthase
HC661_RS07570	COG4221	oxidoreductase activity
HC661_RS07580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS07580	COG4221	oxidoreductase activity
HC661_RS07580	COG3321	synthase
HC661_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS07585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC661_RS07590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC661_RS07595	COG0022	dehydrogenase e1 component
HC661_RS07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC661_RS07605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC661_RS07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS07625	COG1982	Orn Lys Arg decarboxylase major
HC661_RS07645	COG0483	inositol monophosphate 1-phosphatase activity
HC661_RS07655	COG3227	Zinc metalloprotease (Elastase)
HC661_RS07670	COG1595	DNA-templated transcription, initiation
HC661_RS07700	COG4896	Protein conserved in bacteria
HC661_RS07710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC661_RS07715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC661_RS07720	COG2066	Belongs to the glutaminase family
HC661_RS07730	COG0772	Belongs to the SEDS family
HC661_RS07735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC661_RS07750	COG2010	Cytochrome c
HC661_RS07750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC661_RS07755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC661_RS07760	COG1845	cytochrome c oxidase, subunit III
HC661_RS07765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC661_RS07770	COG3336	cytochrome c oxidase
HC661_RS07780	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC661_RS07785	COG2340	Cysteine-rich secretory protein family
HC661_RS07800	COG3679	Belongs to the UPF0342 family
HC661_RS07810	COG0742	ribosomal rna small subunit methyltransferase
HC661_RS07820	COG3314	Sporulation integral membrane protein YlbJ
HC661_RS07825	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC661_RS07830	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC661_RS07840	COG1399	metal-binding, possibly nucleic acid-binding protein
HC661_RS07860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC661_RS07880	COG4839	cell division protein FtsL
HC661_RS07890	COG0768	penicillin binding
HC661_RS07910	COG0772	Belongs to the SEDS family
HC661_RS07925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC661_RS07930	COG0849	cell division
HC661_RS07935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC661_RS07940	COG1404	Belongs to the peptidase S8 family
HC661_RS07940	COG4412	M6 family metalloprotease domain protein
HC661_RS07950	COG1191	sigma factor activity
HC661_RS07955	COG1191	sigma factor activity
HC661_RS07960	COG1119	ATPase activity
HC661_RS07965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC661_RS07970	COG1873	PFAM PRC-barrel domain
HC661_RS07980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC661_RS07990	COG0762	integral membrane protein
HC661_RS07995	COG2302	S4 RNA-binding domain
HC661_RS08000	COG3599	regulation of cell shape
HC661_RS08005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC661_RS08010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC661_RS08020	COG0564	pseudouridine synthase activity
HC661_RS08030	COG2233	PERMEase
HC661_RS08040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC661_RS08045	COG0505	Belongs to the CarA family
HC661_RS08050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC661_RS08065	COG0284	orotidine-5'-phosphate decarboxylase activity
HC661_RS08070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC661_RS08080	COG0306	phosphate transporter
HC661_RS08105	COG1648	precorrin-2 dehydrogenase activity
HC661_RS08115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC661_RS08120	COG1561	YicC-like family, N-terminal region
HC661_RS08130	COG0194	GDP metabolic process
HC661_RS08140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC661_RS08145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC661_RS08150	COG0242	peptide deformylase activity
HC661_RS08160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC661_RS08160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC661_RS08170	COG0631	protein serine/threonine phosphatase activity
HC661_RS08175	COG2815	serine threonine protein kinase
HC661_RS08175	COG0515	serine threonine protein kinase
HC661_RS08185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC661_RS08190	COG1564	THIamine pyrophosphokinase
HC661_RS08205	COG1302	Protein conserved in bacteria
HC661_RS08210	COG1461	Dihydroxyacetone kinase
HC661_RS08215	COG1760	l-serine dehydratase
HC661_RS08220	COG1760	l-serine dehydratase
HC661_RS08225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC661_RS08240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC661_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS08260	COG1196	nuclear chromosome segregation
HC661_RS08265	COG0552	protein localization to endoplasmic reticulum
HC661_RS08280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC661_RS08290	COG1837	Belongs to the UPF0109 family
HC661_RS08315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC661_RS08330	COG2257	FlhB HrpN YscU SpaS Family
HC661_RS08340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC661_RS08345	COG0758	DNA mediated transformation
HC661_RS08350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC661_RS08360	COG4974	Belongs to the 'phage' integrase family
HC661_RS08380	COG1815	bacterial-type flagellum-dependent cell motility
HC661_RS08385	COG1558	bacterial-type flagellum-dependent cell motility
HC661_RS08390	COG1677	Flagellar hook-basal body complex protein FliE
HC661_RS08395	COG1766	The M ring may be actively involved in energy transduction
HC661_RS08400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC661_RS08410	COG1157	protein secretion by the type III secretion system
HC661_RS08415	COG2882	bacterial-type flagellum organization
HC661_RS08425	COG3144	bacterial-type flagellum assembly
HC661_RS08430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC661_RS08435	COG4786	Flagellar basal body rod
HC661_RS08440	COG1582	Flagellar protein (FlbD)
HC661_RS08445	COG1580	Controls the rotational direction of flagella during chemotaxis
HC661_RS08450	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC661_RS08455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC661_RS08455	COG1776	CheC inhibitor of MCP methylation
HC661_RS08460	COG2201	protein-glutamate methylesterase activity
HC661_RS08465	COG3190	flagellar
HC661_RS08470	COG1338	Plays a role in the flagellum-specific transport system
HC661_RS08475	COG1987	bacterial-type flagellum assembly
HC661_RS08480	COG1684	flagellar biosynthetic protein fliR
HC661_RS08485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC661_RS08490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC661_RS08495	COG1419	protein localization to endoplasmic reticulum
HC661_RS08500	COG0455	bacterial-type flagellum organization
HC661_RS08505	COG2201	protein-glutamate methylesterase activity
HC661_RS08510	COG0643	Histidine kinase
HC661_RS08510	COG2198	Histidine kinase
HC661_RS08515	COG0835	chemotaxis
HC661_RS08520	COG1776	CheC inhibitor of MCP methylation
HC661_RS08530	COG1191	sigma factor activity
HC661_RS08560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC661_RS08565	COG4589	Belongs to the CDS family
HC661_RS08575	COG0750	zinc metalloprotease
HC661_RS08585	COG2176	DNA-directed DNA polymerase activity
HC661_RS08595	COG0195	Participates in both transcription termination and antitermination
HC661_RS08600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC661_RS08605	COG1358	cellular component organization or biogenesis
HC661_RS08615	COG1550	Protein conserved in bacteria
HC661_RS08630	COG0196	riboflavin kinase activity
HC661_RS08645	COG0726	polysaccharide deacetylase
HC661_RS08650	COG0612	Peptidase, M16
HC661_RS08655	COG1873	PFAM PRC-barrel domain
HC661_RS08660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC661_RS08665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC661_RS08670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC661_RS08675	COG0527	aspartate kinase activity
HC661_RS08685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC661_RS08690	COG0740	serine-type endopeptidase activity
HC661_RS08700	COG4980	gas vesicle protein
HC661_RS08700	COG1674	ftsk spoiiie
HC661_RS08705	COG2188	Transcriptional regulator
HC661_RS08710	COG2814	Major facilitator Superfamily
HC661_RS08715	COG1846	Transcriptional regulator
HC661_RS08720	COG2409	Drug exporters of the RND superfamily
HC661_RS08720	COG1033	growth of symbiont in host cell
HC661_RS08735	COG0300	oxidoreductase activity
HC661_RS08750	COG1426	Protein conserved in bacteria
HC661_RS08755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC661_RS08770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC661_RS08780	COG1692	metallophosphoesterase
HC661_RS08785	COG2359	stage V sporulation protein S
HC661_RS08805	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC661_RS08825	COG0582	viral genome integration into host DNA
HC661_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS08870	COG3425	synthase
HC661_RS08875	COG1024	Enoyl-CoA hydratase
HC661_RS08880	COG1024	Enoyl-CoA hydratase
HC661_RS08885	COG3321	synthase
HC661_RS08885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS08885	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS08885	COG0300	oxidoreductase activity
HC661_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS08890	COG0300	oxidoreductase activity
HC661_RS08890	COG3321	synthase
HC661_RS08890	COG4221	oxidoreductase activity
HC661_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS08895	COG3321	synthase
HC661_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS08895	COG3321	synthase
HC661_RS08900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS08900	COG3321	synthase
HC661_RS08900	COG4221	oxidoreductase activity
HC661_RS08905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS08905	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC661_RS08905	COG3321	synthase
HC661_RS08905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC661_RS08910	COG2124	cytochrome p450
HC661_RS08915	COG3209	COG3209 Rhs family protein
HC661_RS08920	COG3619	membrane
HC661_RS08930	COG1404	Belongs to the peptidase S8 family
HC661_RS08940	COG4195	phage-related replication protein
HC661_RS08945	COG1764	response to oxidative stress
HC661_RS08955	COG2076	Multidrug Resistance protein
HC661_RS08995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC661_RS09000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC661_RS09005	COG4112	unkown
HC661_RS09010	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS09020	COG0464	growth
HC661_RS09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC661_RS09030	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC661_RS09035	COG0789	Transcriptional regulator
HC661_RS09040	COG0174	glutamine synthetase
HC661_RS09050	COG4282	regulation of fungal-type cell wall biogenesis
HC661_RS09075	COG2211	Major facilitator Superfamily
HC661_RS09080	COG3507	Belongs to the glycosyl hydrolase 43 family
HC661_RS09095	COG1070	Carbohydrate kinase
HC661_RS09100	COG3848	Pyruvate phosphate dikinase
HC661_RS09100	COG0574	Belongs to the PEP-utilizing enzyme family
HC661_RS09120	COG1064	alcohol dehydrogenase
HC661_RS09145	COG0456	acetyltransferase
HC661_RS09170	COG3397	chitin binding
HC661_RS09180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS09195	COG5434	Belongs to the glycosyl hydrolase 28 family
HC661_RS09200	COG0756	dUTP diphosphatase activity
HC661_RS09205	COG4195	phage-related replication protein
HC661_RS09240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC661_RS09250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC661_RS09270	COG0785	Cytochrome C biogenesis protein
HC661_RS09275	COG2201	protein-glutamate methylesterase activity
HC661_RS09280	COG4846	Membrane protein involved in cytochrome C biogenesis
HC661_RS09290	COG0071	Belongs to the small heat shock protein (HSP20) family
HC661_RS09305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC661_RS09310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS09330	COG0824	Thioesterase
HC661_RS09340	COG4841	protein insertion into membrane
HC661_RS09350	COG1832	CoA-binding protein
HC661_RS09355	COG0187	DNA topoisomerase II activity
HC661_RS09360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC661_RS09370	COG1115	amino acid carrier protein
HC661_RS09380	COG1063	alcohol dehydrogenase
HC661_RS09385	COG0800	Aldolase
HC661_RS09390	COG1312	Catalyzes the dehydration of D-mannonate
HC661_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS09400	COG1609	Transcriptional regulator
HC661_RS09405	COG2271	Major facilitator Superfamily
HC661_RS09445	COG2205	protein histidine kinase activity
HC661_RS09450	COG0745	RESPONSE REGULATOR receiver
HC661_RS09460	COG3507	Belongs to the glycosyl hydrolase 43 family
HC661_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS09490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC661_RS09495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC661_RS09500	COG2610	gluconate transmembrane transporter activity
HC661_RS09505	COG2124	cytochrome p450
HC661_RS09525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC661_RS09535	COG2246	polysaccharide biosynthetic process
HC661_RS09540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC661_RS09545	COG0586	Pfam SNARE associated Golgi protein
HC661_RS09550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC661_RS09555	COG1024	Enoyl-CoA hydratase
HC661_RS09560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC661_RS09565	COG0511	ligase activity, forming carbon-carbon bonds
HC661_RS09570	COG0439	Biotin carboxylase
HC661_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS09580	COG1960	acyl-CoA dehydrogenase activity
HC661_RS09595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC661_RS09595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS09600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS09605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS09610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS09615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS09620	COG2027	D-alanyl-D-alanine carboxypeptidase
HC661_RS09625	COG2017	converts alpha-aldose to the beta-anomer
HC661_RS09630	COG0534	Mate efflux family protein
HC661_RS09645	COG0166	Belongs to the GPI family
HC661_RS09650	COG0405	Gamma-glutamyltransferase
HC661_RS09655	COG2814	Major facilitator Superfamily
HC661_RS09660	COG0640	Transcriptional regulator
HC661_RS09675	COG0604	alcohol dehydrogenase
HC661_RS09680	COG0493	'glutamate synthase
HC661_RS09685	COG0070	glutamate synthase
HC661_RS09685	COG0067	glutamate synthase
HC661_RS09685	COG0069	glutamate synthase activity
HC661_RS09690	COG0583	DNA-binding transcription factor activity
HC661_RS09695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC661_RS09710	COG0300	oxidoreductase activity
HC661_RS09715	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC661_RS09725	COG2814	Major facilitator Superfamily
HC661_RS09730	COG1070	Carbohydrate kinase
HC661_RS09735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC661_RS09740	COG0243	molybdopterin cofactor binding
HC661_RS09770	COG5444	nuclease activity
HC661_RS09775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC661_RS09780	COG2207	Transcriptional regulator
HC661_RS09780	COG0662	Cupin 2, conserved barrel domain protein
HC661_RS09785	COG1309	transcriptional regulator
HC661_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS09800	COG0640	Transcriptional regulator
HC661_RS09805	COG0741	lytic transglycosylase activity
HC661_RS09810	COG2322	membrane
HC661_RS09825	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC661_RS09835	COG1388	LysM domain
HC661_RS09835	COG3584	3D domain protein
HC661_RS09840	COG0514	ATP-dependent DNA helicase (RecQ)
HC661_RS09850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC661_RS09855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC661_RS09870	COG0071	Belongs to the small heat shock protein (HSP20) family
HC661_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS09905	COG1657	PFAM Prenyltransferase squalene oxidase
HC661_RS09910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC661_RS09915	COG0733	neurotransmitter:sodium symporter activity
HC661_RS09920	COG0385	Bile acid
HC661_RS09925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS09930	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC661_RS09940	COG4548	von Willebrand factor, type A
HC661_RS09945	COG0714	Associated with various cellular activities
HC661_RS09950	COG2032	superoxide dismutase activity
HC661_RS09955	COG1388	LysM domain
HC661_RS09955	COG0791	NLP P60 protein
HC661_RS09960	COG1819	glycosyl
HC661_RS09965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC661_RS09970	COG0534	Mate efflux family protein
HC661_RS09975	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS09980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC661_RS09985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC661_RS10010	COG1942	4-Oxalocrotonate Tautomerase
HC661_RS10020	COG1733	regulation of RNA biosynthetic process
HC661_RS10025	COG0778	Nitroreductase
HC661_RS10030	COG0400	carboxylic ester hydrolase activity
HC661_RS10035	COG0346	lactoylglutathione lyase activity
HC661_RS10045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC661_RS10055	COG2723	6-phospho-beta-galactosidase activity
HC661_RS10060	COG2188	Transcriptional regulator
HC661_RS10065	COG0793	Belongs to the peptidase S41A family
HC661_RS10065	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS10070	COG2226	methyltransferase
HC661_RS10080	COG1876	peptidase activity
HC661_RS10100	COG0671	phosphoesterase, PA-phosphatase related
HC661_RS10135	COG1509	lysine 2,3-aminomutase activity
HC661_RS10140	COG0456	acetyltransferase
HC661_RS10145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC661_RS10150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC661_RS10155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC661_RS10160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC661_RS10165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HC661_RS10175	COG0456	acetyltransferase
HC661_RS10180	COG0463	Glycosyl transferase, family 2
HC661_RS10195	COG4641	Protein conserved in bacteria
HC661_RS10205	COG1086	Polysaccharide biosynthesis protein
HC661_RS10230	COG1388	LysM domain
HC661_RS10235	COG0457	Tetratricopeptide repeat
HC661_RS10245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC661_RS10250	COG3391	amine dehydrogenase activity
HC661_RS10265	COG5444	nuclease activity
HC661_RS10270	COG4282	regulation of fungal-type cell wall biogenesis
HC661_RS10275	COG1525	nuclease
HC661_RS10300	COG1846	Transcriptional regulator
HC661_RS10305	COG4698	Protein conserved in bacteria
HC661_RS10310	COG2755	lipolytic protein G-D-S-L family
HC661_RS10315	COG1999	signal sequence binding
HC661_RS10325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC661_RS10330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC661_RS10335	COG1272	protein, Hemolysin III
HC661_RS10340	COG0204	Acyl-transferase
HC661_RS10345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC661_RS10360	COG2136	Putative SAM-dependent methyltransferase
HC661_RS10360	COG2521	methyltransferase
HC661_RS10375	COG1413	lyase activity
HC661_RS10380	COG1418	mRNA catabolic process
HC661_RS10385	COG0386	Belongs to the glutathione peroxidase family
HC661_RS10395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC661_RS10405	COG1278	Cold shock
HC661_RS10425	COG0328	RNA-DNA hybrid ribonuclease activity
HC661_RS10430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC661_RS10435	COG0328	RNA-DNA hybrid ribonuclease activity
HC661_RS10445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC661_RS10460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC661_RS10500	COG1335	isochorismatase
HC661_RS10510	COG2233	PERMEase
HC661_RS10520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC661_RS10525	COG1199	ATP-dependent helicase activity
HC661_RS10540	COG0116	Belongs to the methyltransferase superfamily
HC661_RS10570	COG3359	exonuclease
HC661_RS10575	COG1205	dead DEAH box helicase
HC661_RS10575	COG1111	helicase
HC661_RS10580	COG2190	(PTS) system
HC661_RS10585	COG0071	Belongs to the small heat shock protein (HSP20) family
HC661_RS10625	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC661_RS10625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC661_RS10635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC661_RS10640	COG3935	DnaD domain protein
HC661_RS10650	COG0436	Aminotransferase
HC661_RS10655	COG5353	protein conserved in bacteria
HC661_RS10665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC661_RS10665	COG1199	ATP-dependent helicase activity
HC661_RS10695	COG0438	transferase activity, transferring glycosyl groups
HC661_RS10700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC661_RS10715	COG1694	Mazg nucleotide pyrophosphohydrolase
HC661_RS10720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS10735	COG4347	Protein of unknown function (DUF1405)
HC661_RS10740	COG2010	Cytochrome c
HC661_RS10740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC661_RS10750	COG0723	plastoquinol--plastocyanin reductase activity
HC661_RS10765	COG0457	Tetratricopeptide repeat
HC661_RS10775	COG0287	Prephenate dehydrogenase
HC661_RS10810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC661_RS10815	COG4401	Chorismate mutase type I
HC661_RS10830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC661_RS10835	COG0105	UTP biosynthetic process
HC661_RS10840	COG0142	geranyltranstransferase activity
HC661_RS10850	COG0142	geranyltranstransferase activity
HC661_RS10865	COG0776	regulation of translation
HC661_RS10870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC661_RS10910	COG0539	negative regulation of cytoplasmic translation
HC661_RS10925	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC661_RS10930	COG2959	enzyme of heme biosynthesis
HC661_RS10935	COG3773	Cell wall hydrolase
HC661_RS10935	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS10940	COG2339	peptidase activity
HC661_RS10945	COG0492	ferredoxin-NADP+ reductase activity
HC661_RS10950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC661_RS10955	COG4862	establishment of competence for transformation
HC661_RS10960	COG1408	metallophosphoesterase
HC661_RS10970	COG1388	LysM domain
HC661_RS10975	COG1266	CAAX protease self-immunity
HC661_RS10980	COG0514	ATP-dependent DNA helicase (RecQ)
HC661_RS10985	COG4955	Helix-turn-helix domain
HC661_RS10990	COG1141	Ferredoxin
HC661_RS10995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC661_RS11000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC661_RS11010	COG1595	DNA-templated transcription, initiation
HC661_RS11015	COG5002	protein histidine kinase activity
HC661_RS11020	COG0745	RESPONSE REGULATOR receiver
HC661_RS11025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC661_RS11030	COG1333	cytochrome c biogenesis protein
HC661_RS11035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS11040	COG1187	pseudouridine synthase activity
HC661_RS11045	COG0700	Nucleoside recognition
HC661_RS11050	COG2715	membrane protein required for spore maturation
HC661_RS11055	COG1686	Belongs to the peptidase S11 family
HC661_RS11080	COG1547	Domain of unknown function (DUF309)
HC661_RS11085	COG0456	acetyltransferase
HC661_RS11100	COG0307	riboflavin synthase, alpha
HC661_RS11105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC661_RS11105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC661_RS11115	COG0681	Belongs to the peptidase S26 family
HC661_RS11125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC661_RS11130	COG4086	secreted protein
HC661_RS11135	COG0019	diaminopimelate decarboxylase activity
HC661_RS11140	COG0697	spore germination
HC661_RS11155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC661_RS11175	COG1191	sigma factor activity
HC661_RS11185	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS11190	COG1686	Belongs to the peptidase S11 family
HC661_RS11195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC661_RS11200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC661_RS11205	COG4974	Belongs to the 'phage' integrase family
HC661_RS11215	COG0735	belongs to the Fur family
HC661_RS11220	COG1300	Membrane
HC661_RS11235	COG0281	malic enzyme
HC661_RS11240	COG1757	Na H antiporter
HC661_RS11245	COG1027	Aspartate ammonia-lyase
HC661_RS11250	COG0252	asparaginase activity
HC661_RS11255	COG1396	sequence-specific DNA binding
HC661_RS11260	COG1379	DNA repair
HC661_RS11265	COG0494	nUDIX hydrolase
HC661_RS11275	COG0667	Aldo Keto reductase
HC661_RS11285	COG1073	alpha beta
HC661_RS11295	COG4918	Iron-sulphur cluster biosynthesis
HC661_RS11300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC661_RS11300	COG0456	acetyltransferase
HC661_RS11305	COG2329	Antibiotic biosynthesis monooxygenase
HC661_RS11310	COG0456	acetyltransferase
HC661_RS11315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC661_RS11330	COG0628	permease
HC661_RS11340	COG0346	lactoylglutathione lyase activity
HC661_RS11350	COG3048	D-serine ammonia-lyase activity
HC661_RS11355	COG0300	oxidoreductase activity
HC661_RS11360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS11365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC661_RS11370	COG1024	Enoyl-CoA hydratase
HC661_RS11375	COG3425	synthase
HC661_RS11380	COG2124	cytochrome p450
HC661_RS11385	COG3321	synthase
HC661_RS11385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS11385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS11390	COG3321	synthase
HC661_RS11390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS11395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11395	COG0300	oxidoreductase activity
HC661_RS11395	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS11395	COG3321	synthase
HC661_RS11400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11400	COG0300	oxidoreductase activity
HC661_RS11400	COG3321	synthase
HC661_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11400	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS11405	COG3321	synthase
HC661_RS11405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS11405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11410	COG0300	oxidoreductase activity
HC661_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS11410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11410	COG3321	synthase
HC661_RS11415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS11415	COG3321	synthase
HC661_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS11415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC661_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS11425	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS11440	COG2070	2-Nitropropane dioxygenase
HC661_RS11440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC661_RS11445	COG0250	Participates in transcription elongation, termination and antitermination
HC661_RS11460	COG0596	Alpha beta hydrolase
HC661_RS11475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC661_RS11480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC661_RS11495	COG0706	membrane insertase activity
HC661_RS11500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC661_RS11505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC661_RS11510	COG0346	lactoylglutathione lyase activity
HC661_RS11520	COG1376	ErfK ybiS ycfS ynhG family protein
HC661_RS11525	COG4129	membrane
HC661_RS11530	COG1126	abc transporter atp-binding protein
HC661_RS11535	COG0765	amino acid transport
HC661_RS11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS11550	COG1597	lipid kinase activity
HC661_RS11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC661_RS11560	COG0022	dehydrogenase e1 component
HC661_RS11565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC661_RS11570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC661_RS11575	COG3426	butyrate kinase activity
HC661_RS11580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC661_RS11585	COG0280	phosphate acetyltransferase
HC661_RS11590	COG3829	transcription factor binding
HC661_RS11590	COG3290	protein histidine kinase activity
HC661_RS11600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC661_RS11605	COG2079	MmgE PrpD family protein
HC661_RS11610	COG0372	Belongs to the citrate synthase family
HC661_RS11615	COG1960	acyl-CoA dehydrogenase activity
HC661_RS11620	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC661_RS11625	COG0183	Belongs to the thiolase family
HC661_RS11630	COG0584	glycerophosphoryl diester phosphodiesterase
HC661_RS11635	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS11660	COG1902	pentaerythritol trinitrate reductase activity
HC661_RS11675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC661_RS11680	COG0745	RESPONSE REGULATOR receiver
HC661_RS11690	COG0497	DNA recombination
HC661_RS11700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC661_RS11710	COG0142	geranyltranstransferase activity
HC661_RS11720	COG1570	exodeoxyribonuclease VII activity
HC661_RS11735	COG1302	Protein conserved in bacteria
HC661_RS11740	COG0439	Biotin carboxylase
HC661_RS11745	COG0511	ligase activity, forming carbon-carbon bonds
HC661_RS11785	COG3854	ATPases associated with a variety of cellular activities
HC661_RS11800	COG0006	proline dipeptidase activity
HC661_RS11810	COG3872	metal-dependent enzyme
HC661_RS11820	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC661_RS11835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC661_RS11855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC661_RS11870	COG1396	sequence-specific DNA binding
HC661_RS11880	COG0681	Belongs to the peptidase S26 family
HC661_RS11905	COG4940	Competence protein ComGF
HC661_RS11915	COG4970	Tfp pilus assembly protein FimT
HC661_RS11920	COG4537	Required for transformation and DNA binding
HC661_RS11925	COG1459	type II secretion system
HC661_RS11930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC661_RS11935	COG0598	Magnesium transport protein CorA
HC661_RS11940	COG1253	flavin adenine dinucleotide binding
HC661_RS11945	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS11955	COG1393	Belongs to the ArsC family
HC661_RS11965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS11975	COG0011	TIGRFAM Protein of
HC661_RS11985	COG2866	Carboxypeptidase
HC661_RS11990	COG1940	carbohydrate kinase activity
HC661_RS11995	COG4483	Protein conserved in bacteria
HC661_RS12000	COG1757	Na H antiporter
HC661_RS12010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC661_RS12025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC661_RS12030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC661_RS12035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC661_RS12040	COG0581	inorganic phosphate transmembrane transporter activity
HC661_RS12045	COG0573	inorganic phosphate transmembrane transporter activity
HC661_RS12050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC661_RS12060	COG0477	Major facilitator Superfamily
HC661_RS12065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC661_RS12070	COG2839	Protein conserved in bacteria
HC661_RS12075	COG5521	maltodextrose utilization protein MalA
HC661_RS12080	COG1388	LysM domain
HC661_RS12090	COG4709	membrane
HC661_RS12095	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC661_RS12100	COG0735	belongs to the Fur family
HC661_RS12105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS12120	COG0513	Belongs to the DEAD box helicase family
HC661_RS12135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC661_RS12140	COG2384	SAM-dependent methyltransferase
HC661_RS12145	COG2010	Cytochrome c
HC661_RS12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC661_RS12155	COG0358	DNA primase activity
HC661_RS12170	COG0517	IMP dehydrogenase activity
HC661_RS12175	COG0751	glycine-tRNA ligase activity
HC661_RS12195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC661_RS12200	COG0295	cytidine deaminase activity
HC661_RS12205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC661_RS12215	COG1480	7TM receptor with intracellular HD hydrolase
HC661_RS12220	COG1702	phosphate starvation-inducible protein PhoH
HC661_RS12225	COG0561	phosphatase activity
HC661_RS12240	COG4864	UPF0365 protein
HC661_RS12245	COG1030	water channel activity
HC661_RS12250	COG1610	YqeY-like protein
HC661_RS12260	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC661_RS12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC661_RS12270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC661_RS12300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC661_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS12330	COG1466	dna polymerase III delta subunit
HC661_RS12345	COG0658	competence protein
HC661_RS12345	COG2333	competence protein COMEC
HC661_RS12350	COG2131	deaminase
HC661_RS12355	COG1555	photosystem II stabilization
HC661_RS12355	COG1596	polysaccharide export
HC661_RS12360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC661_RS12365	COG2226	methyltransferase
HC661_RS12370	COG0799	negative regulation of ribosome biogenesis
HC661_RS12375	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC661_RS12385	COG1534	Rna-binding protein
HC661_RS12390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC661_RS12395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC661_RS12400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC661_RS12410	COG2755	lipolytic protein G-D-S-L family
HC661_RS12420	COG0398	Pfam SNARE associated Golgi protein
HC661_RS12445	COG1794	racemase activity, acting on amino acids and derivatives
HC661_RS12460	COG0656	L-ascorbic acid biosynthetic process
HC661_RS12490	COG5444	nuclease activity
HC661_RS12495	COG4282	regulation of fungal-type cell wall biogenesis
HC661_RS12515	COG0583	DNA-binding transcription factor activity
HC661_RS12530	COG0642	Histidine kinase
HC661_RS12530	COG5002	protein histidine kinase activity
HC661_RS12535	COG0745	RESPONSE REGULATOR receiver
HC661_RS12540	COG2311	Membrane
HC661_RS12550	COG0454	-acetyltransferase
HC661_RS12555	COG0563	adenylate kinase activity
HC661_RS12565	COG2814	Major facilitator Superfamily
HC661_RS12575	COG0456	acetyltransferase
HC661_RS12580	COG2318	DinB family
HC661_RS12590	COG0561	phosphatase activity
HC661_RS12595	COG0561	phosphatase activity
HC661_RS12605	COG1482	cell wall glycoprotein biosynthetic process
HC661_RS12610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS12610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC661_RS12610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC661_RS12615	COG3711	transcriptional antiterminator
HC661_RS12615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS12625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC661_RS12635	COG2814	Major facilitator Superfamily
HC661_RS12640	COG2124	cytochrome p450
HC661_RS12640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC661_RS12645	COG1309	transcriptional regulator
HC661_RS12650	COG2226	methyltransferase
HC661_RS12665	COG2116	formate transmembrane transporter activity
HC661_RS12670	COG5609	conserved protein (DUF2294)
HC661_RS12675	COG3383	formate dehydrogenase (NAD+) activity
HC661_RS12680	COG2427	Protein of unknown function (DUF1641)
HC661_RS12690	COG0626	cystathionine gamma-synthase activity
HC661_RS12695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC661_RS12720	COG0768	penicillin binding
HC661_RS12745	COG4122	O-methyltransferase activity
HC661_RS12765	COG4472	Bacterial protein of unknown function (DUF965)
HC661_RS12775	COG0628	permease
HC661_RS12780	COG1126	abc transporter atp-binding protein
HC661_RS12785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS12790	COG0765	amino acid transport
HC661_RS12795	COG0765	amino acid transport
HC661_RS12810	COG3881	PFAM PRC-barrel domain
HC661_RS12815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC661_RS12820	COG0457	Tetratricopeptide repeat
HC661_RS12830	COG1104	cysteine desulfurase activity
HC661_RS12835	COG1959	2 iron, 2 sulfur cluster binding
HC661_RS12840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC661_RS12845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC661_RS12870	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS12870	COG4991	sh3 domain protein
HC661_RS12870	COG3103	Sh3 type 3 domain protein
HC661_RS12880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC661_RS12890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC661_RS12890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC661_RS12895	COG5416	Lipopolysaccharide assembly protein A domain
HC661_RS12900	COG0490	domain, Protein
HC661_RS12905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC661_RS12905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC661_RS12915	COG2244	polysaccharide biosynthetic process
HC661_RS12920	COG2323	membrane
HC661_RS12930	COG1862	Preprotein translocase
HC661_RS12970	COG1388	LysM domain
HC661_RS12980	COG0157	Belongs to the NadC ModD family
HC661_RS12985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC661_RS12990	COG1104	cysteine desulfurase activity
HC661_RS12995	COG1827	regulation of RNA biosynthetic process
HC661_RS13000	COG0077	Prephenate dehydratase
HC661_RS13015	COG3290	protein histidine kinase activity
HC661_RS13020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC661_RS13025	COG2868	ribosomal protein
HC661_RS13035	COG1994	Peptidase M50
HC661_RS13040	COG0739	heme binding
HC661_RS13045	COG2894	cell division
HC661_RS13055	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC661_RS13065	COG1077	Cell shape determining protein MreB Mrl
HC661_RS13085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC661_RS13090	COG0285	dihydrofolate synthase activity
HC661_RS13095	COG0525	valine-tRNA ligase activity
HC661_RS13105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC661_RS13110	COG1388	LysM domain
HC661_RS13120	COG0113	porphobilinogen synthase activity
HC661_RS13125	COG1587	Uroporphyrinogen-III synthase
HC661_RS13135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC661_RS13155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC661_RS13175	COG0457	Tetratricopeptide repeat
HC661_RS13175	COG1477	protein flavinylation
HC661_RS13190	COG0473	3-isopropylmalate dehydrogenase activity
HC661_RS13205	COG0440	acetolactate synthase activity
HC661_RS13210	COG0028	Belongs to the TPP enzyme family
HC661_RS13235	COG0622	Phosphoesterase
HC661_RS13240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC661_RS13250	COG5401	PFAM Sporulation and spore germination
HC661_RS13260	COG1846	Transcriptional regulator
HC661_RS13265	COG2197	response regulator
HC661_RS13270	COG0824	Thioesterase
HC661_RS13275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC661_RS13280	COG1053	succinate dehydrogenase
HC661_RS13285	COG2009	succinate dehydrogenase
HC661_RS13290	COG1719	4-vinyl reductase, 4VR
HC661_RS13295	COG0527	aspartate kinase activity
HC661_RS13305	COG3118	belongs to the thioredoxin family
HC661_RS13310	COG3534	alpha-L-arabinofuranosidase
HC661_RS13315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC661_RS13320	COG2086	electron transfer activity
HC661_RS13325	COG1024	Enoyl-CoA hydratase
HC661_RS13330	COG1309	transcriptional regulator
HC661_RS13335	COG0318	PFAM AMP-dependent synthetase and ligase
HC661_RS13345	COG3766	membrane
HC661_RS13355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC661_RS13355	COG1796	DNA polymerase
HC661_RS13360	COG1286	toxin biosynthetic process
HC661_RS13375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC661_RS13375	COG0072	phenylalanine-tRNA ligase activity
HC661_RS13380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC661_RS13385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC661_RS13395	COG3835	regulator
HC661_RS13400	COG0277	FAD linked oxidase domain protein
HC661_RS13405	COG0247	lactate metabolic process
HC661_RS13410	COG1966	Carbon starvation protein
HC661_RS13415	COG3534	alpha-L-arabinofuranosidase
HC661_RS13420	COG0395	ABC-type sugar transport system, permease component
HC661_RS13425	COG1175	transmembrane transport
HC661_RS13430	COG1653	transport
HC661_RS13440	COG0647	UMP catabolic process
HC661_RS13445	COG0235	Class ii aldolase
HC661_RS13450	COG1069	ribulokinase activity
HC661_RS13455	COG2160	L-arabinose isomerase activity
HC661_RS13460	COG3507	Belongs to the glycosyl hydrolase 43 family
HC661_RS13465	COG1363	Peptidase, m42
HC661_RS13475	COG3326	Membrane
HC661_RS13480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC661_RS13490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC661_RS13495	COG1346	cytolysis
HC661_RS13500	COG1380	Effector of murein hydrolase LrgA
HC661_RS13505	COG3279	Response regulator of the LytR AlgR family
HC661_RS13510	COG3275	phosphorelay sensor kinase activity
HC661_RS13515	COG1011	Hydrolase
HC661_RS13530	COG0398	Pfam SNARE associated Golgi protein
HC661_RS13535	COG1484	DNA-dependent DNA replication
HC661_RS13540	COG3611	Membrane attachment protein
HC661_RS13555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC661_RS13560	COG1733	regulation of RNA biosynthetic process
HC661_RS13565	COG2814	Major facilitator Superfamily
HC661_RS13570	COG0656	L-ascorbic acid biosynthetic process
HC661_RS13575	COG0237	dephospho-CoA kinase activity
HC661_RS13580	COG1971	Probably functions as a manganese efflux pump
HC661_RS13585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC661_RS13590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC661_RS13590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC661_RS13595	COG5002	protein histidine kinase activity
HC661_RS13600	COG0745	RESPONSE REGULATOR receiver
HC661_RS13610	COG0538	isocitrate dehydrogenase activity
HC661_RS13615	COG0372	Belongs to the citrate synthase family
HC661_RS13630	COG0628	permease
HC661_RS13635	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC661_RS13640	COG0469	pyruvate kinase activity
HC661_RS13660	COG0281	malic enzyme
HC661_RS13665	COG0587	DNA-directed DNA polymerase activity
HC661_RS13685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC661_RS13695	COG4109	DRTGG domain
HC661_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS13720	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC661_RS13730	COG0827	DNA restriction-modification system
HC661_RS13735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC661_RS13740	COG3874	Sporulation protein YtfJ
HC661_RS13750	COG1714	RDD family
HC661_RS13755	COG0616	signal peptide processing
HC661_RS13760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC661_RS13765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC661_RS13770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC661_RS13785	COG1104	cysteine desulfurase activity
HC661_RS13790	COG1114	Component of the transport system for branched-chain amino acids
HC661_RS13800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC661_RS13805	COG1309	transcriptional regulator
HC661_RS13810	COG1956	GAF domain-containing protein
HC661_RS13830	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS13845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC661_RS13845	COG1017	nitric oxide dioxygenase activity
HC661_RS13855	COG0693	protein deglycase activity
HC661_RS13870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC661_RS13875	COG1378	Sugar-specific transcriptional regulator TrmB
HC661_RS13895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC661_RS13900	COG0454	-acetyltransferase
HC661_RS13905	COG0517	IMP dehydrogenase activity
HC661_RS13910	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC661_RS13915	COG1360	Flagellar Motor Protein
HC661_RS13920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC661_RS13925	COG1609	Transcriptional regulator
HC661_RS13930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC661_RS13930	COG1605	Chorismate mutase
HC661_RS13935	COG3118	belongs to the thioredoxin family
HC661_RS13940	COG4980	gas vesicle protein
HC661_RS13945	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC661_RS13955	COG1674	ftsk spoiiie
HC661_RS13960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC661_RS13970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS13980	COG1363	Peptidase, m42
HC661_RS13985	COG5584	Small secreted protein
HC661_RS13990	COG0281	malic enzyme
HC661_RS13995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC661_RS14010	COG0510	thiamine kinase activity
HC661_RS14015	COG1597	lipid kinase activity
HC661_RS14025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC661_RS14030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC661_RS14035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC661_RS14040	COG2252	PERMEase
HC661_RS14045	COG4473	ABC transporter
HC661_RS14050	COG1131	(ABC) transporter
HC661_RS14055	COG1349	DNA-binding transcription factor activity
HC661_RS14060	COG1187	pseudouridine synthase activity
HC661_RS14065	COG2244	polysaccharide biosynthetic process
HC661_RS14070	COG2081	HI0933 family
HC661_RS14075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC661_RS14085	COG1609	Transcriptional regulator
HC661_RS14090	COG1653	transport
HC661_RS14095	COG1175	transmembrane transport
HC661_RS14100	COG0395	ABC-type sugar transport system, permease component
HC661_RS14105	COG1486	melibiose metabolic process
HC661_RS14115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC661_RS14130	COG2202	Pas domain
HC661_RS14130	COG1366	Belongs to the anti-sigma-factor antagonist family
HC661_RS14135	COG2814	Major facilitator Superfamily
HC661_RS14140	COG5522	Integral membrane protein (intg_mem_TP0381)
HC661_RS14145	COG0577	efflux transmembrane transporter activity
HC661_RS14150	COG1136	(ABC) transporter
HC661_RS14155	COG2205	protein histidine kinase activity
HC661_RS14160	COG0745	RESPONSE REGULATOR receiver
HC661_RS14165	COG0577	efflux transmembrane transporter activity
HC661_RS14170	COG1136	(ABC) transporter
HC661_RS14190	COG1131	(ABC) transporter
HC661_RS14195	COG1725	Transcriptional regulator
HC661_RS14205	COG1242	4 iron, 4 sulfur cluster binding
HC661_RS14210	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC661_RS14220	COG0584	glycerophosphoryl diester phosphodiesterase
HC661_RS14230	COG2267	carboxylic ester hydrolase activity
HC661_RS14235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC661_RS14240	COG1113	amino acid transport
HC661_RS14245	COG0367	asparagine synthase
HC661_RS14265	COG1506	peptidase
HC661_RS14275	COG1116	anion transmembrane transporter activity
HC661_RS14280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC661_RS14285	COG0494	nUDIX hydrolase
HC661_RS14290	COG4824	toxin secretion phage lysis holin
HC661_RS14295	COG0783	Belongs to the Dps family
HC661_RS14320	COG0288	reversible hydration of carbon dioxide
HC661_RS14330	COG1271	oxidase subunit
HC661_RS14335	COG1294	oxidase, subunit
HC661_RS14345	COG4948	Mandelate Racemase Muconate Lactonizing
HC661_RS14355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC661_RS14360	COG0596	Alpha beta hydrolase
HC661_RS14370	COG1169	isochorismate synthase
HC661_RS14375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC661_RS14380	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC661_RS14505	COG3859	Proton-coupled thiamine transporter YuaJ
HC661_RS14510	COG2268	Band 7 protein
HC661_RS14515	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC661_RS14520	COG2318	DinB family
HC661_RS14530	COG1454	alcohol dehydrogenase
HC661_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS14540	COG1510	regulation of RNA biosynthetic process
HC661_RS14550	COG0569	domain protein
HC661_RS14555	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC661_RS14560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC661_RS14560	COG1017	nitric oxide dioxygenase activity
HC661_RS14585	COG0628	permease
HC661_RS14590	COG0673	inositol 2-dehydrogenase activity
HC661_RS14595	COG0693	protein deglycase activity
HC661_RS14600	COG0840	transmembrane signaling receptor activity
HC661_RS14605	COG0840	transmembrane signaling receptor activity
HC661_RS14610	COG0840	transmembrane signaling receptor activity
HC661_RS14615	COG0840	transmembrane signaling receptor activity
HC661_RS14630	COG2070	2-Nitropropane dioxygenase
HC661_RS14635	COG0432	Pfam Uncharacterised protein family UPF0047
HC661_RS14640	COG0366	Alpha amylase catalytic
HC661_RS14645	COG1253	flavin adenine dinucleotide binding
HC661_RS14650	COG2738	Putative neutral zinc metallopeptidase
HC661_RS14665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC661_RS14690	COG1335	isochorismatase
HC661_RS14695	COG1979	alcohol dehydrogenase
HC661_RS14700	COG1979	alcohol dehydrogenase
HC661_RS14705	COG2155	Conserved Protein
HC661_RS14710	COG1098	S1 RNA binding domain
HC661_RS14715	COG0436	Aminotransferase
HC661_RS14720	COG1522	sequence-specific DNA binding
HC661_RS14725	COG2267	carboxylic ester hydrolase activity
HC661_RS14735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC661_RS14740	COG2205	protein histidine kinase activity
HC661_RS14750	COG5018	Exonuclease
HC661_RS14755	COG2814	Major facilitator Superfamily
HC661_RS14760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC661_RS14765	COG3011	Protein conserved in bacteria
HC661_RS14775	COG3290	protein histidine kinase activity
HC661_RS14780	COG4565	transcriptional regulatory protein
HC661_RS14810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC661_RS14810	COG2111	Na H antiporter
HC661_RS14815	COG2111	Na H antiporter
HC661_RS14820	COG1006	Multisubunit Na H antiporter MnhC subunit
HC661_RS14825	COG0651	ATP synthesis coupled electron transport
HC661_RS14830	COG1863	multisubunit Na H antiporter MnhE subunit
HC661_RS14835	COG2212	antiporter activity
HC661_RS14840	COG1320	monovalent cation:proton antiporter activity
HC661_RS14845	COG2050	protein possibly involved in aromatic compounds catabolism
HC661_RS14850	COG2197	response regulator
HC661_RS14865	COG0142	geranyltranstransferase activity
HC661_RS14880	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC661_RS14885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC661_RS14890	COG1335	isochorismatase
HC661_RS14895	COG5506	Protein of unknown function (DUF1694)
HC661_RS14910	COG0628	permease
HC661_RS14920	COG1418	mRNA catabolic process
HC661_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS14935	COG1511	domain protein
HC661_RS14940	COG1674	ftsk spoiiie
HC661_RS14940	COG0433	COG0433 Predicted ATPase
HC661_RS14945	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC661_RS14950	COG5417	Belongs to the EsaB family
HC661_RS14955	COG4842	Belongs to the WXG100 family
HC661_RS14960	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC661_RS14960	COG2508	Transcriptional regulator
HC661_RS14965	COG0686	Belongs to the AlaDH PNT family
HC661_RS14970	COG5634	Uncharacterized conserved protein (DUF2278)
HC661_RS14975	COG3251	PFAM MbtH domain protein
HC661_RS14980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC661_RS14985	COG3433	isochorismatase activity
HC661_RS14985	COG1535	isochorismatase
HC661_RS14990	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC661_RS14995	COG1169	isochorismate synthase
HC661_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS15005	COG2819	hydrolase of the alpha beta superfamily
HC661_RS15010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC661_RS15020	COG2056	Na+-H+ antiporter family
HC661_RS15030	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC661_RS15035	COG3584	3D domain protein
HC661_RS15050	COG1252	NADH dehydrogenase
HC661_RS15080	COG1131	(ABC) transporter
HC661_RS15100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC661_RS15105	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC661_RS15110	COG0316	Belongs to the HesB IscA family
HC661_RS15120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC661_RS15130	COG1252	NADH dehydrogenase
HC661_RS15135	COG4837	Protein of unknown function (DUF1462)
HC661_RS15140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC661_RS15145	COG0823	Involved in the tonB-independent uptake of proteins
HC661_RS15145	COG1506	peptidase
HC661_RS15145	COG4946	Tricorn protease homolog
HC661_RS15155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC661_RS15160	COG0460	homoserine dehydrogenase
HC661_RS15165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC661_RS15170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC661_RS15175	COG0647	UMP catabolic process
HC661_RS15180	COG2445	Protein of unknown function DUF86
HC661_RS15185	COG4470	Protein conserved in bacteria
HC661_RS15195	COG0739	heme binding
HC661_RS15205	COG0737	Belongs to the 5'-nucleotidase family
HC661_RS15210	COG0730	response to heat
HC661_RS15215	COG1801	Protein of unknown function DUF72
HC661_RS15230	COG2508	Transcriptional regulator
HC661_RS15235	COG0457	Tetratricopeptide repeat
HC661_RS15245	COG2814	Major facilitator Superfamily
HC661_RS15250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC661_RS15255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC661_RS15260	COG2356	endonuclease I
HC661_RS15265	COG3842	ATPase activity
HC661_RS15270	COG2188	Transcriptional regulator
HC661_RS15275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC661_RS15280	COG0395	ABC-type sugar transport system, permease component
HC661_RS15285	COG1175	transmembrane transport
HC661_RS15290	COG1653	transport
HC661_RS15295	COG2222	sugar isomerase
HC661_RS15300	COG0789	Transcriptional regulator
HC661_RS15315	COG0322	excinuclease ABC activity
HC661_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC661_RS15325	COG2226	methyltransferase
HC661_RS15335	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS15340	COG0719	Fe-S assembly protein
HC661_RS15345	COG0822	iron-sulfur transferase activity
HC661_RS15350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC661_RS15355	COG0719	Fe-S assembly protein
HC661_RS15360	COG0396	ATPase activity
HC661_RS15370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC661_RS15375	COG1464	Belongs to the NlpA lipoprotein family
HC661_RS15380	COG2011	ABC-type metal ion transport system permease component
HC661_RS15385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC661_RS15395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC661_RS15400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC661_RS15415	COG1393	Belongs to the ArsC family
HC661_RS15420	COG1960	acyl-CoA dehydrogenase activity
HC661_RS15425	COG0183	Belongs to the thiolase family
HC661_RS15430	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC661_RS15430	COG1024	Enoyl-CoA hydratase
HC661_RS15450	COG5577	PFAM Coat F domain
HC661_RS15455	COG1846	Transcriptional regulator
HC661_RS15460	COG0477	Major facilitator Superfamily
HC661_RS15465	COG0583	DNA-binding transcription factor activity
HC661_RS15485	COG1120	ATPase activity
HC661_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS15505	COG0783	Belongs to the Dps family
HC661_RS15510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC661_RS15515	COG0745	RESPONSE REGULATOR receiver
HC661_RS15520	COG2205	protein histidine kinase activity
HC661_RS15520	COG2770	Histidine kinase
HC661_RS15530	COG1309	transcriptional regulator
HC661_RS15535	COG0114	fumarate hydratase activity
HC661_RS15545	COG0697	spore germination
HC661_RS15550	COG0814	amino acid
HC661_RS15560	COG2197	response regulator
HC661_RS15565	COG4585	Histidine kinase
HC661_RS15570	COG4758	membrane
HC661_RS15575	COG3595	metallopeptidase activity
HC661_RS15580	COG1842	Phage shock protein A
HC661_RS15585	COG4758	membrane
HC661_RS15590	COG2814	Major facilitator Superfamily
HC661_RS15595	COG2096	Adenosyltransferase
HC661_RS15600	COG1120	ATPase activity
HC661_RS15605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS15610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS15620	COG3386	PFAM SMP-30 Gluconolaconase
HC661_RS15625	COG2205	protein histidine kinase activity
HC661_RS15630	COG0745	RESPONSE REGULATOR receiver
HC661_RS15650	COG2140	Oxalate decarboxylase
HC661_RS15660	COG1120	ATPase activity
HC661_RS15665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS15670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS15675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS15680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC661_RS15685	COG0531	amino acid
HC661_RS15695	COG1988	membrane-bound metal-dependent
HC661_RS15700	COG1368	sulfuric ester hydrolase activity
HC661_RS15705	COG1910	domain protein
HC661_RS15710	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC661_RS15715	COG4149	molybdate abc transporter
HC661_RS15720	COG2197	response regulator
HC661_RS15725	COG3850	Histidine kinase
HC661_RS15730	COG1131	(ABC) transporter
HC661_RS15740	COG0842	Transport permease protein
HC661_RS15745	COG0656	L-ascorbic acid biosynthetic process
HC661_RS15765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC661_RS15770	COG3973	AAA domain
HC661_RS15775	COG2860	membrane
HC661_RS15785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC661_RS15790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC661_RS15795	COG2217	Heavy metal translocating P-type atpase
HC661_RS15800	COG2217	Heavy metal translocating P-type atpase
HC661_RS15805	COG2608	mercury ion transmembrane transporter activity
HC661_RS15810	COG1937	Protein conserved in bacteria
HC661_RS15815	COG0673	inositol 2-dehydrogenase activity
HC661_RS15830	COG2814	Major facilitator Superfamily
HC661_RS15845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS15850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC661_RS15855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS15860	COG1126	abc transporter atp-binding protein
HC661_RS15865	COG0765	amino acid transport
HC661_RS15870	COG0765	amino acid transport
HC661_RS15875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS15880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC661_RS15885	COG0454	-acetyltransferase
HC661_RS15890	COG0583	DNA-binding transcription factor activity
HC661_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS15905	COG2732	(Barnase) inhibitor
HC661_RS15920	COG0557	exoribonuclease II activity
HC661_RS15925	COG1647	Serine aminopeptidase, S33
HC661_RS15930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC661_RS15935	COG1476	TRANSCRIPTIONal
HC661_RS15960	COG1131	(ABC) transporter
HC661_RS15965	COG1174	glycine betaine transport
HC661_RS15970	COG1732	Glycine betaine
HC661_RS15975	COG1174	glycine betaine transport
HC661_RS15980	COG0517	IMP dehydrogenase activity
HC661_RS15980	COG1125	glycine betaine transport
HC661_RS15985	COG1510	regulation of RNA biosynthetic process
HC661_RS15990	COG1174	glycine betaine transport
HC661_RS15995	COG1732	Glycine betaine
HC661_RS16000	COG1174	glycine betaine transport
HC661_RS16005	COG1125	glycine betaine transport
HC661_RS16005	COG0517	IMP dehydrogenase activity
HC661_RS16010	COG1510	regulation of RNA biosynthetic process
HC661_RS16015	COG2095	MarC family integral membrane protein
HC661_RS16020	COG3064	Membrane
HC661_RS16025	COG4640	response to antibiotic
HC661_RS16030	COG0456	acetyltransferase
HC661_RS16045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC661_RS16060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC661_RS16065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC661_RS16070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC661_RS16080	COG2234	aminopeptidase activity
HC661_RS16100	COG0126	phosphoglycerate kinase activity
HC661_RS16105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC661_RS16110	COG2390	Transcriptional regulator
HC661_RS16115	COG2814	Major facilitator Superfamily
HC661_RS16120	COG1609	Transcriptional regulator
HC661_RS16130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS16135	COG0583	DNA-binding transcription factor activity
HC661_RS16140	COG0697	spore germination
HC661_RS16145	COG1113	amino acid transport
HC661_RS16155	COG1609	Transcriptional regulator
HC661_RS16165	COG0561	phosphatase activity
HC661_RS16175	COG1070	Carbohydrate kinase
HC661_RS16200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS16205	COG2186	Transcriptional regulator
HC661_RS16210	COG1620	l-lactate permease
HC661_RS16215	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC661_RS16225	COG5039	Polysaccharide pyruvyl transferase
HC661_RS16235	COG0110	maltose O-acetyltransferase activity
HC661_RS16240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC661_RS16245	COG2244	polysaccharide biosynthetic process
HC661_RS16250	COG1216	Glycosyl transferase, family 2
HC661_RS16255	COG5039	Polysaccharide pyruvyl transferase
HC661_RS16260	COG1216	Glycosyl transferase, family 2
HC661_RS16270	COG0438	transferase activity, transferring glycosyl groups
HC661_RS16275	COG1215	transferase activity, transferring glycosyl groups
HC661_RS16280	COG0438	transferase activity, transferring glycosyl groups
HC661_RS16285	COG1086	Polysaccharide biosynthesis protein
HC661_RS16290	COG0489	protein tyrosine kinase activity
HC661_RS16295	COG3944	biosynthesis protein
HC661_RS16300	COG1396	sequence-specific DNA binding
HC661_RS16305	COG2272	Belongs to the type-B carboxylesterase lipase family
HC661_RS16310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC661_RS16315	COG2364	Membrane
HC661_RS16320	COG0456	acetyltransferase
HC661_RS16325	COG3479	Phenolic acid decarboxylase
HC661_RS16365	COG2211	Major facilitator Superfamily
HC661_RS16370	COG1609	Transcriptional regulator
HC661_RS16380	COG0583	DNA-binding transcription factor activity
HC661_RS16385	COG2828	Protein conserved in bacteria
HC661_RS16395	COG1611	Belongs to the LOG family
HC661_RS16400	COG1694	Mazg nucleotide pyrophosphohydrolase
HC661_RS16405	COG0659	secondary active sulfate transmembrane transporter activity
HC661_RS16410	COG0288	reversible hydration of carbon dioxide
HC661_RS16420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC661_RS16425	COG4290	ribonuclease
HC661_RS16430	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC661_RS16435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS16445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC661_RS16455	COG1051	belongs to the nudix hydrolase family
HC661_RS16460	COG0492	ferredoxin-NADP+ reductase activity
HC661_RS16465	COG0791	NLP P60 protein
HC661_RS16465	COG3883	PFAM NLP P60 protein
HC661_RS16470	COG0457	Tetratricopeptide repeat
HC661_RS16475	COG5002	protein histidine kinase activity
HC661_RS16480	COG0745	RESPONSE REGULATOR receiver
HC661_RS16490	COG1132	(ABC) transporter
HC661_RS16495	COG0140	phosphoribosyl-ATP diphosphatase activity
HC661_RS16495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC661_RS16520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC661_RS16535	COG4990	cell redox homeostasis
HC661_RS16540	COG0110	maltose O-acetyltransferase activity
HC661_RS16560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC661_RS16570	COG2188	Transcriptional regulator
HC661_RS16575	COG1309	transcriptional regulator
HC661_RS16580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC661_RS16585	COG1950	PFAM Membrane protein of
HC661_RS16590	COG1983	PspC domain protein
HC661_RS16595	COG3595	metallopeptidase activity
HC661_RS16610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC661_RS16620	COG4897	Protein conserved in bacteria
HC661_RS16625	COG3848	Pyruvate phosphate dikinase
HC661_RS16625	COG0574	Belongs to the PEP-utilizing enzyme family
HC661_RS16630	COG1309	transcriptional regulator
HC661_RS16635	COG2814	Major facilitator Superfamily
HC661_RS16680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC661_RS16690	COG0793	Belongs to the peptidase S41A family
HC661_RS16690	COG3409	Peptidoglycan-binding domain 1 protein
HC661_RS16695	COG3420	alginic acid biosynthetic process
HC661_RS16700	COG2177	Part of the ABC transporter FtsEX involved in
HC661_RS16705	COG2884	Cell division ATP-binding protein ftsE
HC661_RS16710	COG2010	Cytochrome c
HC661_RS16715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS16730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC661_RS16745	COG1516	flagellar protein fliS
HC661_RS16750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC661_RS16755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC661_RS16775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC661_RS16780	COG4786	Flagellar basal body rod
HC661_RS16780	COG1256	bacterial-type flagellum assembly
HC661_RS16785	COG3418	PFAM FlgN family protein
HC661_RS16790	COG2747	anti-sigma28 factor FlgM
HC661_RS16800	COG1040	competence protein
HC661_RS16815	COG1307	EDD domain protein, DegV family
HC661_RS16820	COG2197	response regulator
HC661_RS16825	COG4585	Histidine kinase
HC661_RS16830	COG1739	Uncharacterized protein family UPF0029
HC661_RS16835	COG1316	TRANSCRIPTIONal
HC661_RS16840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC661_RS16845	COG0438	transferase activity, transferring glycosyl groups
HC661_RS16850	COG1215	transferase activity, transferring glycosyl groups
HC661_RS16855	COG3206	protein involved in exopolysaccharide biosynthesis
HC661_RS16865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC661_RS16870	COG0297	glycogen (starch) synthase activity
HC661_RS16870	COG0438	transferase activity, transferring glycosyl groups
HC661_RS16875	COG2244	polysaccharide biosynthetic process
HC661_RS16885	COG2247	cell wall binding repeat
HC661_RS16885	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC661_RS16890	COG2247	cell wall binding repeat
HC661_RS16890	COG2385	sporulation resulting in formation of a cellular spore
HC661_RS16900	COG1316	TRANSCRIPTIONal
HC661_RS16905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC661_RS16910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC661_RS16915	COG1134	teichoic acid transport
HC661_RS16920	COG1682	transport, permease protein
HC661_RS16925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC661_RS16935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC661_RS16940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HC661_RS16945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC661_RS16955	COG1482	cell wall glycoprotein biosynthetic process
HC661_RS16965	COG0814	amino acid
HC661_RS16975	COG1215	transferase activity, transferring glycosyl groups
HC661_RS16980	COG2814	Major facilitator Superfamily
HC661_RS16985	COG1316	TRANSCRIPTIONal
HC661_RS16990	COG0561	phosphatase activity
HC661_RS16995	COG2433	Pfam Transposase IS66
HC661_RS17000	COG0791	NLP P60 protein
HC661_RS17010	COG2843	Capsule synthesis protein
HC661_RS17020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC661_RS17025	COG0697	spore germination
HC661_RS17030	COG0814	amino acid
HC661_RS17040	COG1609	Transcriptional regulator
HC661_RS17045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC661_RS17055	COG1129	ABC transporter
HC661_RS17060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC661_RS17065	COG1879	ABC-type sugar transport system periplasmic component
HC661_RS17070	COG3103	Sh3 type 3 domain protein
HC661_RS17075	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC661_RS17080	COG3527	Alpha-acetolactate decarboxylase
HC661_RS17085	COG0028	Belongs to the TPP enzyme family
HC661_RS17090	COG0583	DNA-binding transcription factor activity
HC661_RS17095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC661_RS17110	COG5337	Spore coat protein CotH
HC661_RS17120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC661_RS17130	COG0405	Gamma-glutamyltransferase
HC661_RS17135	COG1522	sequence-specific DNA binding
HC661_RS17140	COG2059	Chromate
HC661_RS17145	COG2059	Chromate
HC661_RS17195	COG5444	nuclease activity
HC661_RS17210	COG3878	Protein conserved in bacteria
HC661_RS17215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC661_RS17220	COG4464	protein tyrosine phosphatase activity
HC661_RS17225	COG0489	protein tyrosine kinase activity
HC661_RS17230	COG3944	biosynthesis protein
HC661_RS17240	COG4715	Zinc finger, swim domain protein
HC661_RS17245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC661_RS17250	COG0561	phosphatase activity
HC661_RS17255	COG1349	DNA-binding transcription factor activity
HC661_RS17260	COG0629	single-stranded DNA binding
HC661_RS17285	COG0457	Tetratricopeptide repeat
HC661_RS17290	COG4786	Flagellar basal body rod
HC661_RS17295	COG4786	Flagellar basal body rod
HC661_RS17300	COG1077	Cell shape determining protein MreB Mrl
HC661_RS17305	COG1609	Transcriptional regulator
HC661_RS17310	COG1846	Transcriptional regulator
HC661_RS17315	COG2814	Major facilitator Superfamily
HC661_RS17320	COG1953	Uracil, thiamine, allantoin
HC661_RS17325	COG0477	Major facilitator Superfamily
HC661_RS17330	COG1335	isochorismatase
HC661_RS17335	COG0004	ammonium transporteR
HC661_RS17340	COG0347	Belongs to the P(II) protein family
HC661_RS17345	COG0772	Belongs to the SEDS family
HC661_RS17350	COG0671	phosphoesterase, PA-phosphatase related
HC661_RS17360	COG0739	heme binding
HC661_RS17365	COG1247	-acetyltransferase
HC661_RS17380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC661_RS17390	COG0726	polysaccharide deacetylase
HC661_RS17395	COG1959	2 iron, 2 sulfur cluster binding
HC661_RS17410	COG0831	urea catabolic process
HC661_RS17420	COG1994	Peptidase M50
HC661_RS17425	COG0457	Tetratricopeptide repeat
HC661_RS17435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC661_RS17445	COG2304	oxidoreductase activity
HC661_RS17450	COG2304	oxidoreductase activity
HC661_RS17455	COG2385	sporulation resulting in formation of a cellular spore
HC661_RS17460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC661_RS17470	COG4836	Membrane
HC661_RS17540	COG0698	ribose 5-phosphate isomerase
HC661_RS17545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC661_RS17555	COG0009	L-threonylcarbamoyladenylate synthase
HC661_RS17560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC661_RS17580	COG2890	protein-(glutamine-N5) methyltransferase activity
HC661_RS17585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC661_RS17590	COG0346	lactoylglutathione lyase activity
HC661_RS17595	COG0789	Transcriptional regulator
HC661_RS17600	COG0679	Auxin Efflux Carrier
HC661_RS17605	COG0281	malic enzyme
HC661_RS17620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC661_RS17625	COG1494	fructose-1,6-bisphosphatase
HC661_RS17630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC661_RS17640	COG0191	fructose-bisphosphate aldolase activity
HC661_RS17645	COG2204	response regulator
HC661_RS17650	COG4821	SIS domain
HC661_RS17670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC661_RS17685	COG1132	(ABC) transporter
HC661_RS17690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC661_RS17700	COG2181	nitrate reductase activity
HC661_RS17705	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC661_RS17710	COG1140	nitrate reductase beta subunit
HC661_RS17715	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC661_RS17720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC661_RS17730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC661_RS17735	COG2223	nitrite transmembrane transporter activity
HC661_RS17745	COG4506	Protein conserved in bacteria
HC661_RS17755	COG3391	amine dehydrogenase activity
HC661_RS17760	COG3391	amine dehydrogenase activity
HC661_RS17765	COG0457	Tetratricopeptide repeat
HC661_RS17805	COG0010	Belongs to the arginase family
HC661_RS17810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC661_RS17815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC661_RS17830	COG1994	Peptidase M50
HC661_RS17835	COG1942	4-Oxalocrotonate Tautomerase
HC661_RS17840	COG1846	Transcriptional regulator
HC661_RS17845	COG0531	amino acid
HC661_RS17850	COG3465	dGTPase activity
HC661_RS17855	COG1078	dGTPase activity
HC661_RS17870	COG1695	Transcriptional regulator
HC661_RS17880	COG1131	(ABC) transporter
HC661_RS17910	COG0583	DNA-binding transcription factor activity
HC661_RS17915	COG2855	membrane
HC661_RS17920	COG0280	phosphate acetyltransferase
HC661_RS17930	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS17935	COG0436	Aminotransferase
HC661_RS17970	COG2814	Major facilitator Superfamily
HC661_RS17975	COG0833	amino acid
HC661_RS17980	COG4187	Peptidase family M20/M25/M40
HC661_RS17985	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS17990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC661_RS18000	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC661_RS18005	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC661_RS18010	COG1088	dTDP-glucose 4,6-dehydratase activity
HC661_RS18015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC661_RS18020	COG3980	spore coat polysaccharide biosynthesis protein
HC661_RS18025	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC661_RS18030	COG2089	acid synthase
HC661_RS18035	COG0456	acetyltransferase
HC661_RS18040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC661_RS18045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC661_RS18050	COG0463	Glycosyl transferase, family 2
HC661_RS18060	COG2363	Small membrane protein
HC661_RS18065	COG2233	PERMEase
HC661_RS18080	COG1216	Glycosyl transferase, family 2
HC661_RS18085	COG0351	phosphomethylpyrimidine kinase
HC661_RS18095	COG1621	beta-fructofuranosidase activity
HC661_RS18100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS18100	COG1263	PTS System
HC661_RS18105	COG3711	transcriptional antiterminator
HC661_RS18115	COG1404	Belongs to the peptidase S8 family
HC661_RS18120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC661_RS18125	COG0778	Nitroreductase
HC661_RS18130	COG0772	Belongs to the SEDS family
HC661_RS18135	COG0454	-acetyltransferase
HC661_RS18155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC661_RS18160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC661_RS18165	COG2261	transglycosylase associated protein
HC661_RS18170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC661_RS18175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC661_RS18180	COG2246	polysaccharide biosynthetic process
HC661_RS18185	COG1309	transcriptional regulator
HC661_RS18205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC661_RS18210	COG2837	iron assimilation
HC661_RS18215	COG2822	iron ion transport
HC661_RS18230	COG0583	DNA-binding transcription factor activity
HC661_RS18240	COG1346	cytolysis
HC661_RS18245	COG4895	conserved protein (DUF2196)
HC661_RS18250	COG0789	Transcriptional regulator
HC661_RS18255	COG5504	Zn-dependent protease
HC661_RS18260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC661_RS18265	COG0346	lactoylglutathione lyase activity
HC661_RS18270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS18275	COG1404	Belongs to the peptidase S8 family
HC661_RS18280	COG1442	glycosyl transferase family 8
HC661_RS18285	COG2357	RelA SpoT domain protein
HC661_RS18290	COG1575	Belongs to the MenA family. Type 1 subfamily
HC661_RS18305	COG1696	Membrane protein involved in D-alanine export
HC661_RS18315	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC661_RS18320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC661_RS18325	COG1486	melibiose metabolic process
HC661_RS18330	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC661_RS18335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS18340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS18345	COG3711	transcriptional antiterminator
HC661_RS18345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC661_RS18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC661_RS18365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS18370	COG0640	Transcriptional regulator
HC661_RS18375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC661_RS18380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS18385	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC661_RS18390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC661_RS18395	COG2723	6-phospho-beta-galactosidase activity
HC661_RS18400	COG1940	carbohydrate kinase activity
HC661_RS18405	COG1482	cell wall glycoprotein biosynthetic process
HC661_RS18415	COG0753	catalase activity
HC661_RS18420	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC661_RS18425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC661_RS18430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC661_RS18435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC661_RS18440	COG4988	ABC transporter
HC661_RS18445	COG1294	oxidase, subunit
HC661_RS18450	COG1271	oxidase subunit
HC661_RS18455	COG3493	citrate carrier protein
HC661_RS18460	COG0726	polysaccharide deacetylase
HC661_RS18465	COG3842	ATPase activity
HC661_RS18470	COG2508	Transcriptional regulator
HC661_RS18475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS18485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC661_RS18500	COG4894	glucomannan catabolic process
HC661_RS18505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC661_RS18510	COG0500	methyltransferase
HC661_RS18515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC661_RS18530	COG0753	catalase activity
HC661_RS18530	COG0693	protein deglycase activity
HC661_RS18535	COG2851	Citrate transporter
HC661_RS18540	COG2273	Hydrolase Family 16
HC661_RS18545	COG3711	transcriptional antiterminator
HC661_RS18550	COG2270	Major facilitator Superfamily
HC661_RS18555	COG0513	Belongs to the DEAD box helicase family
HC661_RS18605	COG3209	COG3209 Rhs family protein
HC661_RS18615	COG0697	spore germination
HC661_RS18620	COG0589	response to stress
HC661_RS18625	COG2723	6-phospho-beta-galactosidase activity
HC661_RS18630	COG1263	PTS System
HC661_RS18630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC661_RS18630	COG2190	(PTS) system
HC661_RS18645	COG3507	Belongs to the glycosyl hydrolase 43 family
HC661_RS18670	COG0010	Belongs to the arginase family
HC661_RS18675	COG0833	amino acid
HC661_RS18680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC661_RS18685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC661_RS18695	COG2390	Transcriptional regulator
HC661_RS18700	COG0561	phosphatase activity
HC661_RS18730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC661_RS18735	COG5294	Protein conserved in bacteria
HC661_RS18740	COG0577	efflux transmembrane transporter activity
HC661_RS18745	COG1136	(ABC) transporter
HC661_RS18750	COG2205	protein histidine kinase activity
HC661_RS18755	COG0745	RESPONSE REGULATOR receiver
HC661_RS18760	COG2205	protein histidine kinase activity
HC661_RS18765	COG0745	RESPONSE REGULATOR receiver
HC661_RS18795	COG1082	Xylose isomerase domain protein TIM barrel
HC661_RS18805	COG2814	Major facilitator Superfamily
HC661_RS18835	COG1349	DNA-binding transcription factor activity
HC661_RS18840	COG0667	Aldo Keto reductase
HC661_RS18845	COG2814	Major facilitator Superfamily
HC661_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS18865	COG2197	response regulator
HC661_RS18870	COG4585	Histidine kinase
HC661_RS18875	COG3239	Fatty acid desaturase
HC661_RS18880	COG1309	transcriptional regulator
HC661_RS18885	COG1012	belongs to the aldehyde dehydrogenase family
HC661_RS18890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC661_RS18900	COG0640	Transcriptional regulator
HC661_RS18905	COG2814	Major facilitator Superfamily
HC661_RS18910	COG1714	RDD family
HC661_RS18920	COG0450	alkyl hydroperoxide reductase
HC661_RS18925	COG3634	alkyl hydroperoxide reductase activity
HC661_RS18930	COG3177	Filamentation induced by cAMP protein fic
HC661_RS18935	COG1113	amino acid transport
HC661_RS18945	COG2080	2 iron, 2 sulfur cluster binding
HC661_RS18960	COG2068	MobA-Related Protein
HC661_RS18965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC661_RS19020	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC661_RS19025	COG0667	Aldo Keto reductase
HC661_RS19030	COG0456	acetyltransferase
HC661_RS19035	COG0457	Tetratricopeptide repeat
HC661_RS19040	COG0010	Belongs to the arginase family
HC661_RS19045	COG0833	amino acid
HC661_RS19050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC661_RS19055	COG5658	integral membrane protein
HC661_RS19060	COG0640	Transcriptional regulator
HC661_RS19065	COG3829	transcription factor binding
HC661_RS19075	COG0488	(ABC) transporter
HC661_RS19090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC661_RS19095	COG5002	protein histidine kinase activity
HC661_RS19095	COG3850	Histidine kinase
HC661_RS19100	COG0745	RESPONSE REGULATOR receiver
HC661_RS19105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC661_RS19110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC661_RS19120	COG4863	YycH protein
HC661_RS19125	COG5002	protein histidine kinase activity
HC661_RS19130	COG0745	RESPONSE REGULATOR receiver
HC661_RS19160	COG0346	lactoylglutathione lyase activity
HC661_RS19180	COG3093	addiction module antidote protein HigA
HC661_RS19185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC661_RS19200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC661_RS19210	COG0438	transferase activity, transferring glycosyl groups
HC661_RS19230	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC661_RS19235	COG4241	membrane
HC661_RS19245	COG5577	PFAM Coat F domain
HC661_RS19250	COG1733	regulation of RNA biosynthetic process
HC661_RS19260	COG0697	spore germination
HC661_RS19275	COG1802	Transcriptional regulator
HC661_RS19280	COG2318	DinB family
HC661_RS19285	COG2211	Major facilitator Superfamily
HC661_RS19290	COG0583	DNA-binding transcription factor activity
HC661_RS19305	COG0778	Nitroreductase
HC661_RS19310	COG1846	Transcriptional regulator
HC661_RS19315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC661_RS19320	COG1846	Transcriptional regulator
HC661_RS19325	COG2153	protein acetylation
HC661_RS19335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC661_RS19340	COG0583	DNA-binding transcription factor activity
HC661_RS19345	COG1028	Short-chain dehydrogenase reductase Sdr
HC661_RS19350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC661_RS19355	COG0697	spore germination
HC661_RS19360	COG1331	Highly conserved protein containing a thioredoxin domain
HC661_RS19385	COG1331	Highly conserved protein containing a thioredoxin domain
HC661_RS19390	COG1331	Highly conserved protein containing a thioredoxin domain
HC661_RS19400	COG0477	Major facilitator Superfamily
HC661_RS19400	COG2814	Major facilitator Superfamily
HC661_RS19405	COG0346	lactoylglutathione lyase activity
HC661_RS19410	COG1609	Transcriptional regulator
HC661_RS19415	COG0708	Exodeoxyribonuclease III
HC661_RS19420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC661_RS19425	COG2169	Transcriptional regulator
HC661_RS19435	COG0629	single-stranded DNA binding
HC661_RS19445	COG0012	GTP binding
HC661_RS19450	COG0243	molybdopterin cofactor binding
HC661_RS19455	COG4481	Protein conserved in bacteria
HC661_RS19460	COG3949	Membrane
HC661_RS19485	COG0243	molybdopterin cofactor binding
HC661_RS19490	COG4481	Protein conserved in bacteria
HC661_RS19495	COG3949	Membrane
HC661_RS19510	COG1475	DNA binding
HC661_RS19515	COG1192	Involved in chromosome partitioning
HC661_RS19540	COG1847	R3H domain protein
HC661_RS19545	COG0706	membrane insertase activity