locus-tag	class	description
E4T61_RS00015	COG0592	DNA-directed DNA polymerase activity
E4T61_RS00020	COG2501	S4 domain
E4T61_RS00035	COG0187	DNA topoisomerase II activity
E4T61_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4T61_RS00065	COG0517	IMP dehydrogenase activity
E4T61_RS00065	COG0516	GMP reductase activity
E4T61_RS00070	COG1686	Belongs to the peptidase S11 family
E4T61_RS00090	COG1929	Belongs to the glycerate kinase type-1 family
E4T61_RS00100	COG1428	Deoxynucleoside kinase
E4T61_RS00105	COG1428	Deoxynucleoside kinase
E4T61_RS00110	COG3858	chitin binding
E4T61_RS00110	COG1388	LysM domain
E4T61_RS00115	COG1335	isochorismatase
E4T61_RS00120	COG0590	tRNA wobble adenosine to inosine editing
E4T61_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4T61_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4T61_RS00175	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
E4T61_RS00180	COG3853	Toxic anion resistance protein (TelA)
E4T61_RS00185	COG1982	Orn Lys Arg decarboxylase major
E4T61_RS00195	COG3870	Protein conserved in bacteria
E4T61_RS00200	COG1728	Protein conserved in bacteria
E4T61_RS00205	COG0470	DNA polymerase III
E4T61_RS00210	COG1774	PSP1 C-terminal conserved region
E4T61_RS00220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4T61_RS00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4T61_RS00235	COG2002	toxin-antitoxin pair type II binding
E4T61_RS00240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T61_RS00240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T61_RS00245	COG0084	hydrolase, TatD family'
E4T61_RS00250	COG3584	3D domain protein
E4T61_RS00250	COG3583	domain protein
E4T61_RS00255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E4T61_RS00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4T61_RS00270	COG4466	Protein conserved in bacteria
E4T61_RS00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4T61_RS00290	COG0251	oxidation-reduction process
E4T61_RS00305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4T61_RS00325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4T61_RS00330	COG2002	toxin-antitoxin pair type II binding
E4T61_RS00335	COG2244	polysaccharide biosynthetic process
E4T61_RS00340	COG3956	TIGRFAM MazG family protein
E4T61_RS00345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4T61_RS00360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4T61_RS00365	COG1098	S1 RNA binding domain
E4T61_RS00380	COG2208	phosphoserine phosphatase activity
E4T61_RS00385	COG2304	oxidoreductase activity
E4T61_RS00390	COG0515	serine threonine protein kinase
E4T61_RS00395	COG0037	tRNA processing
E4T61_RS00400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4T61_RS00405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4T61_RS00420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T61_RS00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T61_RS00430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4T61_RS00435	COG0512	Glutamine amidotransferase of anthranilate synthase
E4T61_RS00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4T61_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T61_RS00455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4T61_RS00460	COG1396	sequence-specific DNA binding
E4T61_RS00465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T61_RS00470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4T61_RS00550	COG4463	regulation of RNA biosynthetic process
E4T61_RS00555	COG3880	PFAM UvrB UvrC protein
E4T61_RS00565	COG0542	response to heat
E4T61_RS00580	COG1132	(ABC) transporter
E4T61_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4T61_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E4T61_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
E4T61_RS00620	COG1045	serine acetyltransferase
E4T61_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E4T61_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T61_RS00640	COG3688	RNA-binding protein containing a PIN domain
E4T61_RS00645	COG1595	DNA-templated transcription, initiation
E4T61_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4T61_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
E4T61_RS00685	COG2813	Specifically methylates the guanine in position
E4T61_RS00700	COG1358	cellular component organization or biogenesis
E4T61_RS00725	COG0596	Alpha beta hydrolase
E4T61_RS00835	COG0201	protein transport
E4T61_RS00845	COG0024	Methionine aminopeptidase
E4T61_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4T61_RS00885	COG1122	ATPase activity
E4T61_RS00890	COG1122	ATPase activity
E4T61_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4T61_RS00915	COG2226	methyltransferase
E4T61_RS00920	COG2318	DinB family
E4T61_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS00935	COG0489	protein tyrosine kinase activity
E4T61_RS00945	COG2194	sulfuric ester hydrolase activity
E4T61_RS00950	COG0726	polysaccharide deacetylase
E4T61_RS01010	COG0738	Major facilitator superfamily
E4T61_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS01030	COG0659	secondary active sulfate transmembrane transporter activity
E4T61_RS01035	COG0385	Bile acid
E4T61_RS01040	COG2819	hydrolase of the alpha beta superfamily
E4T61_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T61_RS01060	COG2207	Transcriptional regulator
E4T61_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T61_RS01065	COG3876	Protein conserved in bacteria
E4T61_RS01070	COG1472	Belongs to the glycosyl hydrolase 3 family
E4T61_RS01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T61_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS01080	COG1263	PTS System
E4T61_RS01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T61_RS01095	COG1683	Conserved Protein
E4T61_RS01125	COG1595	DNA-templated transcription, initiation
E4T61_RS01130	COG5662	AntiSigma factor
E4T61_RS01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4T61_RS01140	COG4856	YbbR-like protein
E4T61_RS01200	COG1346	cytolysis
E4T61_RS01205	COG1380	Effector of murein hydrolase LrgA
E4T61_RS01210	COG1846	Transcriptional regulator
E4T61_RS01215	COG1113	amino acid transport
E4T61_RS01220	COG1011	Hydrolase
E4T61_RS01225	COG4585	Histidine kinase
E4T61_RS01230	COG2197	response regulator
E4T61_RS01235	COG1131	(ABC) transporter
E4T61_RS01275	COG0531	amino acid
E4T61_RS01290	COG0584	glycerophosphoryl diester phosphodiesterase
E4T61_RS01295	COG2271	Major facilitator Superfamily
E4T61_RS01310	COG2368	4-hydroxyphenylacetate
E4T61_RS01320	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS01335	COG0371	Dehydrogenase
E4T61_RS01345	COG1183	phosphatidylcholine synthase activity
E4T61_RS01350	COG0586	Pfam SNARE associated Golgi protein
E4T61_RS01355	COG0688	phosphatidylethanolamine metabolic process
E4T61_RS01370	COG1301	dicarboxylic acid transport
E4T61_RS01375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS01380	COG0833	amino acid
E4T61_RS01385	COG2040	homocysteine
E4T61_RS01390	COG1115	amino acid carrier protein
E4T61_RS01395	COG2066	Belongs to the glutaminase family
E4T61_RS01400	COG4191	Histidine kinase
E4T61_RS01405	COG0784	Response regulator, receiver
E4T61_RS01415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4T61_RS01420	COG0778	Nitroreductase
E4T61_RS01425	COG0346	lactoylglutathione lyase activity
E4T61_RS01430	COG2259	Doxx family
E4T61_RS01435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS01450	COG3773	Cell wall hydrolase
E4T61_RS01460	COG3540	Alkaline phosphatase
E4T61_RS01465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T61_RS01470	COG0805	protein transport
E4T61_RS01480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4T61_RS01485	COG0477	Major facilitator Superfamily
E4T61_RS01490	COG1309	transcriptional regulator
E4T61_RS01495	COG0252	asparaginase activity
E4T61_RS01500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4T61_RS01505	COG1405	negative regulation of cell septum assembly
E4T61_RS01505	COG3012	SEC-C Motif Domain Protein
E4T61_RS01510	COG0667	Aldo Keto reductase
E4T61_RS01520	COG1595	DNA-templated transcription, initiation
E4T61_RS01525	COG1595	DNA-templated transcription, initiation
E4T61_RS01530	COG1876	peptidase activity
E4T61_RS01535	COG0457	Tetratricopeptide repeat
E4T61_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS01545	COG0366	Alpha amylase catalytic
E4T61_RS01550	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4T61_RS01555	COG1121	(ABC) transporter
E4T61_RS01560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T61_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS01570	COG2310	stress, protein
E4T61_RS01575	COG2310	stress, protein
E4T61_RS01580	COG2310	stress, protein
E4T61_RS01585	COG0861	Integral membrane protein TerC family
E4T61_RS01595	COG3853	Toxic anion resistance protein (TelA)
E4T61_RS01600	COG0477	Major facilitator Superfamily
E4T61_RS01605	COG4175	Glycine betaine
E4T61_RS01605	COG0517	IMP dehydrogenase activity
E4T61_RS01610	COG4176	ABC-type proline glycine betaine transport system permease component
E4T61_RS01615	COG2113	Glycine betaine
E4T61_RS01620	COG1473	amidohydrolase
E4T61_RS01625	COG1288	antiporter activity
E4T61_RS01635	COG0366	Alpha amylase catalytic
E4T61_RS01645	COG2814	Major facilitator Superfamily
E4T61_RS01650	COG1846	Transcriptional regulator
E4T61_RS01655	COG1280	lysine exporter protein (LysE YggA)
E4T61_RS01660	COG3403	YqcI/YcgG family
E4T61_RS01665	COG1113	amino acid transport
E4T61_RS01670	COG3665	Urea carboxylase-associated protein
E4T61_RS01685	COG1660	Displays ATPase and GTPase activities
E4T61_RS01690	COG1082	Xylose isomerase domain protein TIM barrel
E4T61_RS01695	COG2271	Major facilitator Superfamily
E4T61_RS01700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4T61_RS01705	COG3458	cephalosporin-C deacetylase activity
E4T61_RS01710	COG3541	Predicted nucleotidyltransferase
E4T61_RS01715	COG0506	proline dehydrogenase activity
E4T61_RS01720	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS01725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T61_RS01730	COG2508	Transcriptional regulator
E4T61_RS01740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4T61_RS01740	COG1587	Uroporphyrinogen-III synthase
E4T61_RS01745	COG2146	nitrite reductase [NAD(P)H] activity
E4T61_RS01750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T61_RS01755	COG0243	molybdopterin cofactor binding
E4T61_RS01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T61_RS01765	COG2223	nitrite transmembrane transporter activity
E4T61_RS01770	COG0523	cobalamin synthesis protein
E4T61_RS01775	COG1063	alcohol dehydrogenase
E4T61_RS01780	COG1714	RDD family
E4T61_RS01790	COG2723	6-phospho-beta-galactosidase activity
E4T61_RS01800	COG3209	COG3209 Rhs family protein
E4T61_RS01805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4T61_RS01810	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E4T61_RS01815	COG1733	regulation of RNA biosynthetic process
E4T61_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS01825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS01835	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E4T61_RS01850	COG0697	spore germination
E4T61_RS01855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS01865	COG2364	Membrane
E4T61_RS01870	COG1126	abc transporter atp-binding protein
E4T61_RS01875	COG0765	amino acid transport
E4T61_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS01885	COG0583	DNA-binding transcription factor activity
E4T61_RS01890	COG0163	prenyltransferase activity
E4T61_RS01895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T61_RS01910	COG3104	oligopeptide transport
E4T61_RS01915	COG5434	Belongs to the glycosyl hydrolase 28 family
E4T61_RS01925	COG0697	spore germination
E4T61_RS01935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T61_RS01940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS01945	COG0456	acetyltransferase
E4T61_RS01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS01955	COG0765	amino acid transport
E4T61_RS01960	COG1126	abc transporter atp-binding protein
E4T61_RS01965	COG1473	amidohydrolase
E4T61_RS01970	COG2079	MmgE PrpD family protein
E4T61_RS01975	COG1136	(ABC) transporter
E4T61_RS01985	COG0745	RESPONSE REGULATOR receiver
E4T61_RS01990	COG5002	protein histidine kinase activity
E4T61_RS01990	COG3850	Histidine kinase
E4T61_RS01995	COG0457	Tetratricopeptide repeat
E4T61_RS02010	COG0527	aspartate kinase activity
E4T61_RS02015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS02020	COG4605	iron ion homeostasis
E4T61_RS02025	COG4604	ABC transporter, ATP-binding protein
E4T61_RS02030	COG4607	ABC-type enterochelin transport system periplasmic component
E4T61_RS02035	COG2814	Major facilitator Superfamily
E4T61_RS02040	COG1309	transcriptional regulator
E4T61_RS02045	COG0778	Nitroreductase
E4T61_RS02050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4T61_RS02055	COG0640	Transcriptional regulator
E4T61_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS02065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS02070	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS02075	COG4975	Glucose uptake
E4T61_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS02085	COG4549	nuclear export factor GLE1
E4T61_RS02090	COG1276	copper resistance
E4T61_RS02090	COG2372	response to copper ion
E4T61_RS02095	COG1349	DNA-binding transcription factor activity
E4T61_RS02105	COG2213	PTS system mannitol-specific
E4T61_RS02110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS02120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T61_RS02130	COG0561	phosphatase activity
E4T61_RS02140	COG1914	H( )-stimulated, divalent metal cation uptake system
E4T61_RS02150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4T61_RS02155	COG1984	allophanate hydrolase subunit 2
E4T61_RS02160	COG1414	Transcriptional regulator
E4T61_RS02165	COG2755	lipolytic protein G-D-S-L family
E4T61_RS02175	COG2329	Antibiotic biosynthesis monooxygenase
E4T61_RS02180	COG0768	penicillin binding
E4T61_RS02185	COG4989	oxidoreductase activity
E4T61_RS02190	COG3711	transcriptional antiterminator
E4T61_RS02195	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS02205	COG1917	Cupin 2, conserved barrel domain protein
E4T61_RS02210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T61_RS02215	COG3871	stress protein (general stress protein 26)
E4T61_RS02225	COG2814	Major facilitator Superfamily
E4T61_RS02230	COG1522	sequence-specific DNA binding
E4T61_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T61_RS02235	COG0551	DNA topoisomerase type I activity
E4T61_RS02240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4T61_RS02245	COG3706	GGDEF domain
E4T61_RS02250	COG5298	Protein conserved in bacteria
E4T61_RS02255	COG1215	transferase activity, transferring glycosyl groups
E4T61_RS02265	COG0531	amino acid
E4T61_RS02270	COG0494	nUDIX hydrolase
E4T61_RS02275	COG0028	Belongs to the TPP enzyme family
E4T61_RS02305	COG1914	H( )-stimulated, divalent metal cation uptake system
E4T61_RS02320	COG4876	unkown
E4T61_RS02330	COG2076	Multidrug Resistance protein
E4T61_RS02335	COG2217	Heavy metal translocating P-type atpase
E4T61_RS02340	COG3729	General stress protein
E4T61_RS02345	COG0662	Cupin 2, conserved barrel domain protein
E4T61_RS02350	COG2329	Antibiotic biosynthesis monooxygenase
E4T61_RS02355	COG3546	catalase activity
E4T61_RS02360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T61_RS02365	COG3290	protein histidine kinase activity
E4T61_RS02370	COG4565	transcriptional regulatory protein
E4T61_RS02375	COG1301	dicarboxylic acid transport
E4T61_RS02380	COG0628	permease
E4T61_RS02385	COG1131	(ABC) transporter
E4T61_RS02390	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4T61_RS02400	COG1960	acyl-CoA dehydrogenase activity
E4T61_RS02415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4T61_RS02420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4T61_RS02435	COG0513	Belongs to the DEAD box helicase family
E4T61_RS02440	COG3402	PFAM membrane-flanked domain
E4T61_RS02445	COG3428	Bacterial PH domain
E4T61_RS02450	COG0705	Rhomboid family
E4T61_RS02460	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4T61_RS02465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T61_RS02470	COG0864	Transcriptional regulator
E4T61_RS02475	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4T61_RS02480	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS02485	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS02490	COG2172	sigma factor antagonist activity
E4T61_RS02495	COG2208	phosphoserine phosphatase activity
E4T61_RS02500	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS02510	COG1191	sigma factor activity
E4T61_RS02515	COG2208	phosphoserine phosphatase activity
E4T61_RS02520	COG2183	response to ionizing radiation
E4T61_RS02570	COG0582	viral genome integration into host DNA
E4T61_RS02575	COG2856	Zn peptidase
E4T61_RS02580	COG1396	sequence-specific DNA binding
E4T61_RS02605	COG1674	ftsk spoiiie
E4T61_RS02610	COG2946	Replication initiation factor
E4T61_RS02655	COG0433	COG0433 Predicted ATPase
E4T61_RS02665	COG5644	endopeptidase inhibitor activity
E4T61_RS02670	COG0741	lytic transglycosylase activity
E4T61_RS02670	COG0791	NLP P60 protein
E4T61_RS02695	COG0457	Tetratricopeptide repeat
E4T61_RS02735	COG0604	alcohol dehydrogenase
E4T61_RS02745	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS02750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T61_RS02755	COG1090	epimerase
E4T61_RS02760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T61_RS02775	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T61_RS02800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T61_RS02805	COG0477	Major facilitator Superfamily
E4T61_RS02810	COG1846	Transcriptional regulator
E4T61_RS02820	COG2030	dehydratase
E4T61_RS02835	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS02840	COG2910	NAD(P)H-binding
E4T61_RS02845	COG3239	Fatty acid desaturase
E4T61_RS02855	COG1278	Cold shock
E4T61_RS02860	COG1329	Transcriptional regulator
E4T61_RS02865	COG1937	Protein conserved in bacteria
E4T61_RS02870	COG2210	Belongs to the sulfur carrier protein TusA family
E4T61_RS02880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T61_RS02880	COG0425	Belongs to the sulfur carrier protein TusA family
E4T61_RS02885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T61_RS02885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS02890	COG0425	Belongs to the sulfur carrier protein TusA family
E4T61_RS02895	COG0730	response to heat
E4T61_RS02900	COG1794	racemase activity, acting on amino acids and derivatives
E4T61_RS02915	COG0456	acetyltransferase
E4T61_RS02915	COG1846	Transcriptional regulator
E4T61_RS02920	COG2271	Major facilitator Superfamily
E4T61_RS02925	COG3621	Patatin-like phospholipase
E4T61_RS02935	COG0662	Cupin 2, conserved barrel domain protein
E4T61_RS02950	COG0277	FAD linked oxidase domain protein
E4T61_RS02975	COG0662	Cupin 2, conserved barrel domain protein
E4T61_RS02980	COG2318	DinB family
E4T61_RS02985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T61_RS03010	COG1064	alcohol dehydrogenase
E4T61_RS03015	COG0789	Transcriptional regulator
E4T61_RS03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS03060	COG2814	Major facilitator Superfamily
E4T61_RS03065	COG1309	transcriptional regulator
E4T61_RS03070	COG0697	spore germination
E4T61_RS03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS03080	COG5577	PFAM Coat F domain
E4T61_RS03090	COG1063	alcohol dehydrogenase
E4T61_RS03095	COG5577	PFAM Coat F domain
E4T61_RS03105	COG0738	Major facilitator superfamily
E4T61_RS03115	COG0110	maltose O-acetyltransferase activity
E4T61_RS03120	COG4585	Histidine kinase
E4T61_RS03125	COG2197	response regulator
E4T61_RS03130	COG2409	Drug exporters of the RND superfamily
E4T61_RS03135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4T61_RS03140	COG0477	Major facilitator Superfamily
E4T61_RS03145	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS03150	COG0488	(ABC) transporter
E4T61_RS03155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T61_RS03160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS03170	COG2814	Major facilitator Superfamily
E4T61_RS03175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T61_RS03185	COG0730	response to heat
E4T61_RS03190	COG0456	acetyltransferase
E4T61_RS03195	COG0789	Transcriptional regulator
E4T61_RS03195	COG4978	Transcriptional regulator
E4T61_RS03200	COG0697	spore germination
E4T61_RS03205	COG1051	belongs to the nudix hydrolase family
E4T61_RS03210	COG2226	methyltransferase
E4T61_RS03215	COG0473	3-isopropylmalate dehydrogenase activity
E4T61_RS03220	COG1802	Transcriptional regulator
E4T61_RS03225	COG1819	glycosyl
E4T61_RS03240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T61_RS03245	COG1388	LysM domain
E4T61_RS03250	COG2814	Major facilitator Superfamily
E4T61_RS03255	COG2188	Transcriptional regulator
E4T61_RS03260	COG2186	Transcriptional regulator
E4T61_RS03265	COG2807	transmembrane transport
E4T61_RS03270	COG2076	Multidrug Resistance protein
E4T61_RS03275	COG2076	Multidrug Resistance protein
E4T61_RS03280	COG1309	transcriptional regulator
E4T61_RS03285	COG0531	amino acid
E4T61_RS03295	COG3832	glyoxalase III activity
E4T61_RS03300	COG0604	alcohol dehydrogenase
E4T61_RS03305	COG2814	Major facilitator Superfamily
E4T61_RS03345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4T61_RS03350	COG0802	atpase or kinase
E4T61_RS03355	COG1214	PFAM Peptidase M22, glycoprotease
E4T61_RS03360	COG0456	acetyltransferase
E4T61_RS03365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4T61_RS03370	COG0488	(ABC) transporter
E4T61_RS03385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T61_RS03390	COG0805	protein transport
E4T61_RS03400	COG1266	CAAX protease self-immunity
E4T61_RS03430	COG0457	Tetratricopeptide repeat
E4T61_RS03435	COG1063	alcohol dehydrogenase
E4T61_RS03440	COG2211	Major facilitator Superfamily
E4T61_RS03445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T61_RS03455	COG1842	Phage shock protein A
E4T61_RS03460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4T61_RS03465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4T61_RS03470	COG4260	virion core protein, lumpy skin disease virus
E4T61_RS03475	COG2755	lipolytic protein G-D-S-L family
E4T61_RS03475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4T61_RS03485	COG1595	DNA-templated transcription, initiation
E4T61_RS03490	COG1063	alcohol dehydrogenase
E4T61_RS03495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T61_RS03500	COG0823	Involved in the tonB-independent uptake of proteins
E4T61_RS03510	COG2132	Multicopper oxidase
E4T61_RS03515	COG1113	amino acid transport
E4T61_RS03520	COG0714	Associated with various cellular activities
E4T61_RS03525	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
E4T61_RS03530	COG1305	Transglutaminase-like
E4T61_RS03550	COG2252	PERMEase
E4T61_RS03555	COG3064	Membrane
E4T61_RS03575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4T61_RS03580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4T61_RS03585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4T61_RS03590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4T61_RS03595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4T61_RS03610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4T61_RS03620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4T61_RS03625	COG0138	bifunctional purine biosynthesis protein purh
E4T61_RS03630	COG0151	Belongs to the GarS family
E4T61_RS03640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4T61_RS03645	COG1470	cell adhesion involved in biofilm formation
E4T61_RS03650	COG4496	protein, YerC YecD
E4T61_RS03655	COG0069	glutamate synthase activity
E4T61_RS03665	COG0210	DNA helicase
E4T61_RS03675	COG4851	CamS sex pheromone cAM373 precursor
E4T61_RS03680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4T61_RS03685	COG1285	pathogenesis
E4T61_RS03690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T61_RS03710	COG1309	transcriptional regulator
E4T61_RS03715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T61_RS03720	COG1597	lipid kinase activity
E4T61_RS03725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T61_RS03735	COG1131	(ABC) transporter
E4T61_RS03755	COG5444	nuclease activity
E4T61_RS03780	COG3546	catalase activity
E4T61_RS03785	COG0454	-acetyltransferase
E4T61_RS03795	COG2323	membrane
E4T61_RS03800	COG2329	Antibiotic biosynthesis monooxygenase
E4T61_RS03805	COG0346	lactoylglutathione lyase activity
E4T61_RS03815	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS03820	COG5583	Uncharacterized small protein (DUF2292)
E4T61_RS03825	COG0196	riboflavin kinase activity
E4T61_RS03830	COG0670	Belongs to the BI1 family
E4T61_RS03835	COG1846	Transcriptional regulator
E4T61_RS03840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T61_RS03850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4T61_RS03850	COG2124	cytochrome p450
E4T61_RS03865	COG1131	(ABC) transporter
E4T61_RS03880	COG1368	sulfuric ester hydrolase activity
E4T61_RS03885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4T61_RS03890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS03895	COG1442	glycosyl transferase family 8
E4T61_RS03900	COG1216	Glycosyl transferase, family 2
E4T61_RS03905	COG1442	glycosyl transferase family 8
E4T61_RS03910	COG2223	nitrite transmembrane transporter activity
E4T61_RS03915	COG0531	amino acid
E4T61_RS03920	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS03925	COG0840	transmembrane signaling receptor activity
E4T61_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS03935	COG0463	Glycosyl transferase, family 2
E4T61_RS03935	COG0457	Tetratricopeptide repeat
E4T61_RS03940	COG0488	(ABC) transporter
E4T61_RS03945	COG0789	Transcriptional regulator
E4T61_RS03950	COG2814	Major facilitator Superfamily
E4T61_RS03955	COG0488	(ABC) transporter
E4T61_RS03960	COG0513	Belongs to the DEAD box helicase family
E4T61_RS03965	COG0456	acetyltransferase
E4T61_RS03970	COG2130	NADP-dependent
E4T61_RS03985	COG3866	Pectate lyase
E4T61_RS03990	COG0471	metal ion transport
E4T61_RS04010	COG2972	Histidine kinase
E4T61_RS04010	COG0745	RESPONSE REGULATOR receiver
E4T61_RS04015	COG3279	Response regulator of the LytR AlgR family
E4T61_RS04025	COG3764	Sortase (surface protein transpeptidase)
E4T61_RS04030	COG3290	protein histidine kinase activity
E4T61_RS04035	COG4565	transcriptional regulatory protein
E4T61_RS04040	COG3181	Tripartite tricarboxylate transporter family receptor
E4T61_RS04045	COG2851	Citrate transporter
E4T61_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS04055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E4T61_RS04065	COG2258	MOSC domain
E4T61_RS04085	COG0024	Methionine aminopeptidase
E4T61_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS04090	COG1263	PTS System
E4T61_RS04100	COG1368	sulfuric ester hydrolase activity
E4T61_RS04110	COG0071	Belongs to the small heat shock protein (HSP20) family
E4T61_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS04125	COG1263	PTS System
E4T61_RS04130	COG0366	Alpha amylase catalytic
E4T61_RS04135	COG2188	Transcriptional regulator
E4T61_RS04140	COG0778	Nitroreductase
E4T61_RS04155	COG0737	Belongs to the 5'-nucleotidase family
E4T61_RS04160	COG0693	protein deglycase activity
E4T61_RS04165	COG1609	Transcriptional regulator
E4T61_RS04185	COG2814	Major facilitator Superfamily
E4T61_RS04195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T61_RS04200	COG4980	gas vesicle protein
E4T61_RS04205	COG1295	ribonuclease BN
E4T61_RS04210	COG0477	Major facilitator Superfamily
E4T61_RS04215	COG0387	Pfam Sodium calcium exchanger
E4T61_RS04225	COG0668	transmembrane transport
E4T61_RS04230	COG0535	radical SAM domain protein
E4T61_RS04240	COG0726	polysaccharide deacetylase
E4T61_RS04245	COG2084	Dehydrogenase
E4T61_RS04255	COG0598	Magnesium transport protein CorA
E4T61_RS04260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4T61_RS04265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T61_RS04275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T61_RS04280	COG4637	Psort location Cytoplasmic, score
E4T61_RS04285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4T61_RS04290	COG0022	dehydrogenase e1 component
E4T61_RS04295	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T61_RS04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T61_RS04305	COG3284	Transcriptional regulator
E4T61_RS04315	COG1486	melibiose metabolic process
E4T61_RS04320	COG1737	Transcriptional regulator
E4T61_RS04325	COG1263	PTS System
E4T61_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS04330	COG5434	Belongs to the glycosyl hydrolase 28 family
E4T61_RS04335	COG1132	(ABC) transporter
E4T61_RS04340	COG1132	(ABC) transporter
E4T61_RS04345	COG2259	Doxx family
E4T61_RS04350	COG2514	catechol 2,3-dioxygenase activity
E4T61_RS04365	COG1695	Transcriptional regulator
E4T61_RS04370	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T61_RS04375	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
E4T61_RS04380	COG3848	Pyruvate phosphate dikinase
E4T61_RS04380	COG0574	Belongs to the PEP-utilizing enzyme family
E4T61_RS04385	COG2732	(Barnase) inhibitor
E4T61_RS04390	COG2318	DinB family
E4T61_RS04395	COG2814	Major facilitator Superfamily
E4T61_RS04400	COG1846	Transcriptional regulator
E4T61_RS04405	COG0392	lysyltransferase activity
E4T61_RS04405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4T61_RS04410	COG0384	phenazine biosynthesis protein PhzF
E4T61_RS04415	COG0778	Nitroreductase
E4T61_RS04430	COG1090	epimerase
E4T61_RS04445	COG2814	Major facilitator Superfamily
E4T61_RS04455	COG3591	Belongs to the peptidase S1B family
E4T61_RS04470	COG3103	Sh3 type 3 domain protein
E4T61_RS04475	COG5658	integral membrane protein
E4T61_RS04480	COG0596	Alpha beta hydrolase
E4T61_RS04485	COG0463	Glycosyl transferase, family 2
E4T61_RS04490	COG4485	Bacterial membrane protein, YfhO
E4T61_RS04495	COG1988	membrane-bound metal-dependent
E4T61_RS04500	COG1194	a g-specific adenine glycosylase
E4T61_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS04530	COG1132	(ABC) transporter
E4T61_RS04535	COG4129	membrane
E4T61_RS04545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4T61_RS04550	COG0735	belongs to the Fur family
E4T61_RS04660	COG1757	Na H antiporter
E4T61_RS04665	COG3340	Belongs to the peptidase S51 family
E4T61_RS04675	COG0277	FAD linked oxidase domain protein
E4T61_RS04685	COG0747	negative chemotaxis
E4T61_RS04690	COG0601	transmembrane transport
E4T61_RS04695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T61_RS04700	COG0444	Belongs to the ABC transporter superfamily
E4T61_RS04705	COG4608	Belongs to the ABC transporter superfamily
E4T61_RS04710	COG0753	catalase activity
E4T61_RS04725	COG1116	anion transmembrane transporter activity
E4T61_RS04730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T61_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T61_RS04755	COG1476	TRANSCRIPTIONal
E4T61_RS04765	COG3382	B3 4 domain protein
E4T61_RS04770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4T61_RS04780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4T61_RS04785	COG0789	Transcriptional regulator
E4T61_RS04790	COG1664	Polymer-forming cytoskeletal
E4T61_RS04795	COG1664	Polymer-forming cytoskeletal
E4T61_RS04800	COG2766	serine protein kinase
E4T61_RS04815	COG1846	Transcriptional regulator
E4T61_RS04820	COG1566	PFAM secretion protein HlyD family protein
E4T61_RS04825	COG2814	Major facilitator Superfamily
E4T61_RS04830	COG0655	NAD(P)H dehydrogenase (quinone) activity
E4T61_RS04845	COG1725	Transcriptional regulator
E4T61_RS04850	COG1131	(ABC) transporter
E4T61_RS04855	COG1131	(ABC) transporter
E4T61_RS04860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4T61_RS04865	COG1278	Cold shock
E4T61_RS04875	COG1464	Belongs to the NlpA lipoprotein family
E4T61_RS04880	COG3706	GGDEF domain
E4T61_RS04885	COG1823	symporter activity
E4T61_RS04905	COG5577	PFAM Coat F domain
E4T61_RS04910	COG0737	Belongs to the 5'-nucleotidase family
E4T61_RS04910	COG1525	nuclease
E4T61_RS04910	COG4085	toxin activity
E4T61_RS04915	COG3764	Sortase (surface protein transpeptidase)
E4T61_RS04920	COG0564	pseudouridine synthase activity
E4T61_RS04930	COG0517	IMP dehydrogenase activity
E4T61_RS04935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T61_RS04940	COG3153	acetyltransferase
E4T61_RS04940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T61_RS04945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T61_RS04950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4T61_RS04955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4T61_RS04965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4T61_RS04970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T61_RS04975	COG4585	Histidine kinase
E4T61_RS04975	COG2203	Gaf domain
E4T61_RS04980	COG2197	response regulator
E4T61_RS04985	COG0431	NADPH-dependent FMN reductase
E4T61_RS05000	COG1388	LysM domain
E4T61_RS05000	COG0791	NLP P60 protein
E4T61_RS05005	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS05010	COG0668	transmembrane transport
E4T61_RS05015	COG2719	SpoVR family
E4T61_RS05020	COG1785	Belongs to the alkaline phosphatase family
E4T61_RS05025	COG0791	NLP P60 protein
E4T61_RS05025	COG1388	LysM domain
E4T61_RS05030	COG0583	DNA-binding transcription factor activity
E4T61_RS05035	COG0372	Belongs to the citrate synthase family
E4T61_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS05045	COG0531	amino acid
E4T61_RS05050	COG0733	neurotransmitter:sodium symporter activity
E4T61_RS05065	COG1595	DNA-templated transcription, initiation
E4T61_RS05070	COG0204	Acyl-transferase
E4T61_RS05075	COG1253	flavin adenine dinucleotide binding
E4T61_RS05080	COG0789	Transcriptional regulator
E4T61_RS05085	COG0436	Aminotransferase
E4T61_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T61_RS05095	COG1253	flavin adenine dinucleotide binding
E4T61_RS05100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4T61_RS05105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4T61_RS05110	COG0584	glycerophosphoryl diester phosphodiesterase
E4T61_RS05120	COG0668	transmembrane transport
E4T61_RS05125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4T61_RS05130	COG0726	polysaccharide deacetylase
E4T61_RS05135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS05140	COG3226	Transcriptional regulator
E4T61_RS05150	COG0589	response to stress
E4T61_RS05155	COG1132	(ABC) transporter
E4T61_RS05160	COG1132	(ABC) transporter
E4T61_RS05165	COG0702	epimerase
E4T61_RS05185	COG0189	ligase activity
E4T61_RS05190	COG0189	ligase activity
E4T61_RS05205	COG4335	DNA alkylation repair
E4T61_RS05210	COG0561	phosphatase activity
E4T61_RS05215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T61_RS05225	COG0475	glutathione-regulated potassium exporter activity
E4T61_RS05230	COG0490	domain, Protein
E4T61_RS05240	COG1024	Enoyl-CoA hydratase
E4T61_RS05250	COG4152	abc transporter atp-binding protein
E4T61_RS05255	COG1668	transmembrane transport
E4T61_RS05260	COG0420	3'-5' exonuclease activity
E4T61_RS05265	COG4717	serine-type aminopeptidase activity
E4T61_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T61_RS05325	COG4980	gas vesicle protein
E4T61_RS05340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4T61_RS05345	COG0537	adenosine 5'-monophosphoramidase activity
E4T61_RS05350	COG1131	(ABC) transporter
E4T61_RS05355	COG4473	ABC transporter
E4T61_RS05365	COG1473	amidohydrolase
E4T61_RS05370	COG3069	C4-dicarboxylate transmembrane transporter activity
E4T61_RS05375	COG2329	Antibiotic biosynthesis monooxygenase
E4T61_RS05380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T61_RS05390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4T61_RS05395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E4T61_RS05400	COG1309	transcriptional regulator
E4T61_RS05405	COG1511	domain protein
E4T61_RS05410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4T61_RS05420	COG1363	Peptidase, m42
E4T61_RS05425	COG1301	dicarboxylic acid transport
E4T61_RS05435	COG1234	tRNA 3'-trailer cleavage
E4T61_RS05440	COG0095	Lipoate-protein ligase
E4T61_RS05445	COG0702	epimerase
E4T61_RS05450	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS05460	COG0501	Belongs to the peptidase M48B family
E4T61_RS05465	COG1404	Belongs to the peptidase S8 family
E4T61_RS05475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4T61_RS05480	COG0406	alpha-ribazole phosphatase activity
E4T61_RS05485	COG0183	Belongs to the thiolase family
E4T61_RS05490	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS05495	COG1268	BioY protein
E4T61_RS05500	COG0840	transmembrane signaling receptor activity
E4T61_RS05505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T61_RS05505	COG0723	plastoquinol--plastocyanin reductase activity
E4T61_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS05520	COG4903	ComK protein
E4T61_RS05530	COG5646	InterPro IPR014922
E4T61_RS05555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T61_RS05570	COG0398	Pfam SNARE associated Golgi protein
E4T61_RS05575	COG0681	Belongs to the peptidase S26 family
E4T61_RS05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T61_RS05585	COG1846	Transcriptional regulator
E4T61_RS05590	COG3180	Ammonia monooxygenase
E4T61_RS05595	COG2814	Major facilitator Superfamily
E4T61_RS05605	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
E4T61_RS05610	COG2323	membrane
E4T61_RS05625	COG0420	3'-5' exonuclease activity
E4T61_RS05630	COG0419	ATPase involved in DNA repair
E4T61_RS05635	COG1403	HNH endonuclease
E4T61_RS05675	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4T61_RS05695	COG0367	asparagine synthase
E4T61_RS05700	COG1562	ergosterol biosynthetic process
E4T61_RS05705	COG0534	Mate efflux family protein
E4T61_RS05710	COG2207	Transcriptional regulator
E4T61_RS05710	COG1917	Cupin 2, conserved barrel domain protein
E4T61_RS05715	COG2318	DinB family
E4T61_RS05720	COG1279	arginine transmembrane transporter activity
E4T61_RS05725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS05730	COG1357	PFAM Pentapeptide repeats (8 copies)
E4T61_RS05735	COG2153	protein acetylation
E4T61_RS05740	COG0646	methionine synthase
E4T61_RS05740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4T61_RS05750	COG2996	Protein conserved in bacteria
E4T61_RS05755	COG1744	ABC transporter substrate-binding protein PnrA-like
E4T61_RS05760	COG0840	transmembrane signaling receptor activity
E4T61_RS05765	COG2124	cytochrome p450
E4T61_RS05775	COG1307	EDD domain protein, DegV family
E4T61_RS05780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS05795	COG0561	phosphatase activity
E4T61_RS05800	COG1073	alpha beta
E4T61_RS05805	COG2151	metal-sulfur cluster biosynthetic enzyme
E4T61_RS05815	COG0277	FAD linked oxidase domain protein
E4T61_RS05820	COG2271	Major facilitator Superfamily
E4T61_RS05830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4T61_RS05840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T61_RS05845	COG0505	Belongs to the CarA family
E4T61_RS05850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4T61_RS05855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T61_RS05875	COG2267	carboxylic ester hydrolase activity
E4T61_RS05885	COG1744	ABC transporter substrate-binding protein PnrA-like
E4T61_RS05900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4T61_RS05905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T61_RS05910	COG5504	Zn-dependent protease
E4T61_RS05915	COG0444	Belongs to the ABC transporter superfamily
E4T61_RS05920	COG4608	Belongs to the ABC transporter superfamily
E4T61_RS05930	COG0601	transmembrane transport
E4T61_RS05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T61_RS05945	COG0180	Tryptophanyl-tRNA synthetase
E4T61_RS05950	COG4166	transmembrane transport
E4T61_RS05955	COG0601	transmembrane transport
E4T61_RS05960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T61_RS05965	COG0444	Belongs to the ABC transporter superfamily
E4T61_RS05970	COG4608	Belongs to the ABC transporter superfamily
E4T61_RS05980	COG0456	acetyltransferase
E4T61_RS05985	COG1393	Belongs to the ArsC family
E4T61_RS05990	COG0861	Integral membrane protein TerC family
E4T61_RS05995	COG4862	establishment of competence for transformation
E4T61_RS06000	COG4469	Competence protein
E4T61_RS06005	COG1164	Oligoendopeptidase f
E4T61_RS06010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4T61_RS06015	COG2346	COG2346, Truncated hemoglobins
E4T61_RS06020	COG0741	lytic transglycosylase activity
E4T61_RS06025	COG4116	CYTH
E4T61_RS06035	COG2357	RelA SpoT domain protein
E4T61_RS06040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4T61_RS06045	COG0564	pseudouridine synthase activity
E4T61_RS06060	COG0569	domain protein
E4T61_RS06060	COG0475	glutathione-regulated potassium exporter activity
E4T61_RS06065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4T61_RS06070	COG0352	thiamine-phosphate diphosphorylase activity
E4T61_RS06075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T61_RS06080	COG2104	thiamine diphosphate biosynthetic process
E4T61_RS06090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T61_RS06095	COG0351	phosphomethylpyrimidine kinase
E4T61_RS06100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4T61_RS06155	COG0210	DNA helicase
E4T61_RS06175	COG1131	(ABC) transporter
E4T61_RS06185	COG2153	protein acetylation
E4T61_RS06195	COG2382	esterase
E4T61_RS06200	COG0626	cystathionine gamma-synthase activity
E4T61_RS06205	COG0626	cystathionine gamma-synthase activity
E4T61_RS06220	COG5444	nuclease activity
E4T61_RS06230	COG0346	lactoylglutathione lyase activity
E4T61_RS06235	COG2367	Beta-lactamase
E4T61_RS06240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4T61_RS06250	COG1846	Transcriptional regulator
E4T61_RS06260	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E4T61_RS06265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4T61_RS06270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4T61_RS06275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS06275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS06280	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4T61_RS06310	COG1285	pathogenesis
E4T61_RS06325	COG2205	protein histidine kinase activity
E4T61_RS06335	COG3383	formate dehydrogenase (NAD+) activity
E4T61_RS06340	COG2427	Protein of unknown function (DUF1641)
E4T61_RS06345	COG2124	cytochrome p450
E4T61_RS06350	COG1819	glycosyl
E4T61_RS06360	COG1587	Uroporphyrinogen-III synthase
E4T61_RS06365	COG0390	transport system, permease component
E4T61_RS06370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T61_RS06375	COG0697	spore germination
E4T61_RS06380	COG4297	protein containing double-stranded beta helix domain
E4T61_RS06390	COG1252	NADH dehydrogenase
E4T61_RS06400	COG2211	Major facilitator Superfamily
E4T61_RS06405	COG1609	Transcriptional regulator
E4T61_RS06410	COG0246	Mannitol dehydrogenase
E4T61_RS06415	COG2721	sulfolactate sulfo-lyase activity
E4T61_RS06420	COG0745	RESPONSE REGULATOR receiver
E4T61_RS06425	COG2770	Histidine kinase
E4T61_RS06425	COG2205	protein histidine kinase activity
E4T61_RS06445	COG0730	response to heat
E4T61_RS06450	COG2318	DinB family
E4T61_RS06455	COG0457	Tetratricopeptide repeat
E4T61_RS06465	COG1388	LysM domain
E4T61_RS06465	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS06465	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS06475	COG4195	phage-related replication protein
E4T61_RS06480	COG2856	Zn peptidase
E4T61_RS06485	COG1396	sequence-specific DNA binding
E4T61_RS06495	COG1522	sequence-specific DNA binding
E4T61_RS06500	COG1484	DNA-dependent DNA replication
E4T61_RS06515	COG1595	DNA-templated transcription, initiation
E4T61_RS06520	COG5484	DNA packaging
E4T61_RS06520	COG3728	DNA packaging
E4T61_RS06525	COG1783	phage Terminase large subunit
E4T61_RS06530	COG5518	Phage portal protein
E4T61_RS06535	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4T61_RS06540	COG4653	Phage capsid family
E4T61_RS06590	COG3953	SLT domain
E4T61_RS06590	COG3953	SLT domain
E4T61_RS06590	COG3953	SLT domain
E4T61_RS06590	COG5412	phage tail tape measure protein
E4T61_RS06590	COG5412	phage tail tape measure protein
E4T61_RS06590	COG5412	phage tail tape measure protein
E4T61_RS06595	COG1652	LysM domain
E4T61_RS06600	COG4193	domain, Protein
E4T61_RS06610	COG3628	GPW Gp25 family protein
E4T61_RS06615	COG3299	homolog of phage Mu protein gp47
E4T61_RS06620	COG3778	Protein conserved in bacteria
E4T61_RS06660	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS06660	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS06675	COG0306	phosphate transporter
E4T61_RS06680	COG1392	Phosphate transport regulator
E4T61_RS06685	COG0531	amino acid
E4T61_RS06690	COG0346	lactoylglutathione lyase activity
E4T61_RS06695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T61_RS06700	COG0463	Glycosyl transferase, family 2
E4T61_RS06705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T61_RS06710	COG0477	Major facilitator Superfamily
E4T61_RS06715	COG2362	D-Aminopeptidase
E4T61_RS06720	COG0601	transmembrane transport
E4T61_RS06725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T61_RS06730	COG0444	Belongs to the ABC transporter superfamily
E4T61_RS06735	COG4166	transmembrane transport
E4T61_RS06740	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4T61_RS06745	COG4948	Mandelate Racemase Muconate Lactonizing
E4T61_RS06750	COG0791	NLP P60 protein
E4T61_RS06755	COG4608	Belongs to the ABC transporter superfamily
E4T61_RS06760	COG2706	6-phosphogluconolactonase activity
E4T61_RS06765	COG1834	amidinotransferase
E4T61_RS06770	COG1607	acyl-coa hydrolase
E4T61_RS06775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T61_RS06780	COG2076	Multidrug Resistance protein
E4T61_RS06785	COG2076	Multidrug Resistance protein
E4T61_RS06790	COG0788	formyltetrahydrofolate deformylase activity
E4T61_RS06795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4T61_RS06805	COG1764	response to oxidative stress
E4T61_RS06810	COG1846	Transcriptional regulator
E4T61_RS06815	COG1764	response to oxidative stress
E4T61_RS06830	COG0463	Glycosyl transferase, family 2
E4T61_RS06830	COG0457	Tetratricopeptide repeat
E4T61_RS06840	COG2814	Major facilitator Superfamily
E4T61_RS06855	COG1404	Belongs to the peptidase S8 family
E4T61_RS06860	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS06865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4T61_RS06870	COG1122	ATPase activity
E4T61_RS06875	COG4721	ABC-type cobalt transport system, permease component
E4T61_RS06880	COG3858	chitin binding
E4T61_RS06880	COG1388	LysM domain
E4T61_RS06900	COG2239	Acts as a magnesium transporter
E4T61_RS06905	COG0789	Transcriptional regulator
E4T61_RS06920	COG1846	Transcriptional regulator
E4T61_RS06925	COG0726	polysaccharide deacetylase
E4T61_RS06930	COG1793	dna ligase
E4T61_RS06930	COG3285	dna ligase
E4T61_RS06935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E4T61_RS06940	COG0586	Pfam SNARE associated Golgi protein
E4T61_RS06945	COG0861	Integral membrane protein TerC family
E4T61_RS06950	COG1191	sigma factor activity
E4T61_RS06975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4T61_RS06980	COG2323	membrane
E4T61_RS06990	COG3594	Acyltransferase
E4T61_RS06995	COG5002	protein histidine kinase activity
E4T61_RS07000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T61_RS07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T61_RS07020	COG0436	Aminotransferase
E4T61_RS07050	COG3852	Histidine kinase
E4T61_RS07055	COG1846	Transcriptional regulator
E4T61_RS07060	COG1360	Flagellar Motor Protein
E4T61_RS07065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4T61_RS07070	COG0542	response to heat
E4T61_RS07080	COG3949	Membrane
E4T61_RS07095	COG0720	synthase
E4T61_RS07100	COG0602	queuosine metabolic process
E4T61_RS07110	COG1733	regulation of RNA biosynthetic process
E4T61_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS07130	COG4873	Protein conserved in bacteria
E4T61_RS07140	COG3773	Cell wall hydrolase
E4T61_RS07145	COG2244	polysaccharide biosynthetic process
E4T61_RS07150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS07155	COG2217	Heavy metal translocating P-type atpase
E4T61_RS07160	COG0006	proline dipeptidase activity
E4T61_RS07165	COG1609	Transcriptional regulator
E4T61_RS07170	COG3711	transcriptional antiterminator
E4T61_RS07175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS07175	COG2190	(PTS) system
E4T61_RS07175	COG1263	PTS System
E4T61_RS07180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS07185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T61_RS07195	COG1533	DNA photolyase activity
E4T61_RS07200	COG0840	transmembrane signaling receptor activity
E4T61_RS07205	COG2084	Dehydrogenase
E4T61_RS07220	COG0347	Belongs to the P(II) protein family
E4T61_RS07225	COG2340	Cysteine-rich secretory protein family
E4T61_RS07230	COG0768	penicillin binding
E4T61_RS07235	COG4191	Histidine kinase
E4T61_RS07240	COG0436	Aminotransferase
E4T61_RS07250	COG0784	Response regulator, receiver
E4T61_RS07250	COG0835	chemotaxis
E4T61_RS07260	COG2814	Major facilitator Superfamily
E4T61_RS07265	COG1376	ErfK ybiS ycfS ynhG family protein
E4T61_RS07270	COG1408	metallophosphoesterase
E4T61_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS07285	COG2200	EAL domain
E4T61_RS07290	COG4703	Protein of unknown function (DUF1797)
E4T61_RS07295	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E4T61_RS07305	COG0517	IMP dehydrogenase activity
E4T61_RS07310	COG0583	DNA-binding transcription factor activity
E4T61_RS07315	COG0716	FMN binding
E4T61_RS07325	COG0716	FMN binding
E4T61_RS07345	COG0668	transmembrane transport
E4T61_RS07350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS07370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T61_RS07375	COG0303	'Molybdopterin
E4T61_RS07380	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4T61_RS07385	COG0314	molybdopterin synthase activity
E4T61_RS07390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4T61_RS07400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T61_RS07405	COG1136	(ABC) transporter
E4T61_RS07410	COG0577	efflux transmembrane transporter activity
E4T61_RS07415	COG1349	DNA-binding transcription factor activity
E4T61_RS07420	COG1105	Belongs to the carbohydrate kinase PfkB family
E4T61_RS07425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T61_RS07425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS07425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T61_RS07430	COG0681	Belongs to the peptidase S26 family
E4T61_RS07440	COG0488	(ABC) transporter
E4T61_RS07445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4T61_RS07450	COG2309	aminopeptidase activity
E4T61_RS07460	COG1077	Cell shape determining protein MreB Mrl
E4T61_RS07470	COG2002	toxin-antitoxin pair type II binding
E4T61_RS07475	COG3852	Histidine kinase
E4T61_RS07480	COG2105	PFAM AIG2 family protein
E4T61_RS07480	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4T61_RS07485	COG0569	domain protein
E4T61_RS07495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4T61_RS07505	COG0561	phosphatase activity
E4T61_RS07510	COG0242	peptide deformylase activity
E4T61_RS07520	COG0497	DNA recombination
E4T61_RS07535	COG4221	oxidoreductase activity
E4T61_RS07535	COG3321	synthase
E4T61_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS07535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS07540	COG0300	oxidoreductase activity
E4T61_RS07540	COG4221	oxidoreductase activity
E4T61_RS07540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS07540	COG3321	synthase
E4T61_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS07545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS07545	COG4221	oxidoreductase activity
E4T61_RS07545	COG3321	synthase
E4T61_RS07550	COG4221	oxidoreductase activity
E4T61_RS07550	COG0300	oxidoreductase activity
E4T61_RS07550	COG3321	synthase
E4T61_RS07550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS07555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS07555	COG0300	oxidoreductase activity
E4T61_RS07555	COG3321	synthase
E4T61_RS07555	COG4221	oxidoreductase activity
E4T61_RS07560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS07560	COG0300	oxidoreductase activity
E4T61_RS07560	COG3321	synthase
E4T61_RS07560	COG4221	oxidoreductase activity
E4T61_RS07565	COG4221	oxidoreductase activity
E4T61_RS07565	COG3321	synthase
E4T61_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS07565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS07570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T61_RS07575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4T61_RS07580	COG0022	dehydrogenase e1 component
E4T61_RS07585	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T61_RS07590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T61_RS07595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS07610	COG1982	Orn Lys Arg decarboxylase major
E4T61_RS07635	COG0483	inositol monophosphate 1-phosphatase activity
E4T61_RS07645	COG3227	Zinc metalloprotease (Elastase)
E4T61_RS07650	COG1595	DNA-templated transcription, initiation
E4T61_RS07670	COG1217	gtp-binding protein TYPA
E4T61_RS07680	COG4896	Protein conserved in bacteria
E4T61_RS07690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4T61_RS07695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4T61_RS07700	COG2066	Belongs to the glutaminase family
E4T61_RS07710	COG0772	Belongs to the SEDS family
E4T61_RS07715	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4T61_RS07730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T61_RS07730	COG2010	Cytochrome c
E4T61_RS07735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T61_RS07740	COG1845	cytochrome c oxidase, subunit III
E4T61_RS07745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4T61_RS07750	COG3336	cytochrome c oxidase
E4T61_RS07760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E4T61_RS07765	COG2340	Cysteine-rich secretory protein family
E4T61_RS07780	COG3679	Belongs to the UPF0342 family
E4T61_RS07790	COG0742	ribosomal rna small subunit methyltransferase
E4T61_RS07800	COG3314	Sporulation integral membrane protein YlbJ
E4T61_RS07805	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4T61_RS07810	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4T61_RS07820	COG1399	metal-binding, possibly nucleic acid-binding protein
E4T61_RS07840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4T61_RS07860	COG4839	cell division protein FtsL
E4T61_RS07865	COG0768	penicillin binding
E4T61_RS07870	COG0768	penicillin binding
E4T61_RS07890	COG0772	Belongs to the SEDS family
E4T61_RS07905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4T61_RS07910	COG0849	cell division
E4T61_RS07915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4T61_RS07920	COG4412	M6 family metalloprotease domain protein
E4T61_RS07920	COG1404	Belongs to the peptidase S8 family
E4T61_RS07930	COG1191	sigma factor activity
E4T61_RS07935	COG1191	sigma factor activity
E4T61_RS07940	COG1119	ATPase activity
E4T61_RS07945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T61_RS07950	COG1873	PFAM PRC-barrel domain
E4T61_RS07955	COG1496	oxidoreductase activity
E4T61_RS07960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4T61_RS07970	COG0762	integral membrane protein
E4T61_RS07975	COG2302	S4 RNA-binding domain
E4T61_RS07980	COG3599	regulation of cell shape
E4T61_RS07990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4T61_RS07995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T61_RS08005	COG0564	pseudouridine synthase activity
E4T61_RS08015	COG2233	PERMEase
E4T61_RS08025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4T61_RS08030	COG0505	Belongs to the CarA family
E4T61_RS08035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4T61_RS08050	COG0284	orotidine-5'-phosphate decarboxylase activity
E4T61_RS08055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4T61_RS08065	COG0306	phosphate transporter
E4T61_RS08080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4T61_RS08085	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
E4T61_RS08090	COG1648	precorrin-2 dehydrogenase activity
E4T61_RS08105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4T61_RS08110	COG1561	YicC-like family, N-terminal region
E4T61_RS08120	COG0194	GDP metabolic process
E4T61_RS08130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4T61_RS08135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4T61_RS08140	COG0242	peptide deformylase activity
E4T61_RS08150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4T61_RS08150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4T61_RS08160	COG0631	protein serine/threonine phosphatase activity
E4T61_RS08165	COG0515	serine threonine protein kinase
E4T61_RS08165	COG2815	serine threonine protein kinase
E4T61_RS08175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4T61_RS08180	COG1564	THIamine pyrophosphokinase
E4T61_RS08195	COG1302	Protein conserved in bacteria
E4T61_RS08200	COG1461	Dihydroxyacetone kinase
E4T61_RS08205	COG1760	l-serine dehydratase
E4T61_RS08210	COG1760	l-serine dehydratase
E4T61_RS08215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4T61_RS08230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4T61_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS08250	COG1196	nuclear chromosome segregation
E4T61_RS08255	COG0552	protein localization to endoplasmic reticulum
E4T61_RS08270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4T61_RS08280	COG1837	Belongs to the UPF0109 family
E4T61_RS08305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4T61_RS08320	COG2257	FlhB HrpN YscU SpaS Family
E4T61_RS08330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4T61_RS08335	COG0758	DNA mediated transformation
E4T61_RS08340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T61_RS08350	COG4974	Belongs to the 'phage' integrase family
E4T61_RS08370	COG1815	bacterial-type flagellum-dependent cell motility
E4T61_RS08375	COG1558	bacterial-type flagellum-dependent cell motility
E4T61_RS08380	COG1677	Flagellar hook-basal body complex protein FliE
E4T61_RS08385	COG1766	The M ring may be actively involved in energy transduction
E4T61_RS08390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T61_RS08395	COG1317	bacterial-type flagellum organization
E4T61_RS08400	COG1157	protein secretion by the type III secretion system
E4T61_RS08405	COG2882	bacterial-type flagellum organization
E4T61_RS08410	COG3334	PFAM MgtE intracellular
E4T61_RS08415	COG3144	bacterial-type flagellum assembly
E4T61_RS08420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4T61_RS08425	COG4786	Flagellar basal body rod
E4T61_RS08430	COG1582	Flagellar protein (FlbD)
E4T61_RS08435	COG1580	Controls the rotational direction of flagella during chemotaxis
E4T61_RS08440	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T61_RS08445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T61_RS08445	COG1776	CheC inhibitor of MCP methylation
E4T61_RS08450	COG2201	protein-glutamate methylesterase activity
E4T61_RS08455	COG3190	flagellar
E4T61_RS08460	COG1338	Plays a role in the flagellum-specific transport system
E4T61_RS08465	COG1987	bacterial-type flagellum assembly
E4T61_RS08470	COG1684	flagellar biosynthetic protein fliR
E4T61_RS08475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4T61_RS08480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4T61_RS08485	COG1419	protein localization to endoplasmic reticulum
E4T61_RS08490	COG0455	bacterial-type flagellum organization
E4T61_RS08495	COG2201	protein-glutamate methylesterase activity
E4T61_RS08500	COG0643	Histidine kinase
E4T61_RS08500	COG2198	Histidine kinase
E4T61_RS08505	COG0835	chemotaxis
E4T61_RS08510	COG1776	CheC inhibitor of MCP methylation
E4T61_RS08520	COG1191	sigma factor activity
E4T61_RS08550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4T61_RS08555	COG4589	Belongs to the CDS family
E4T61_RS08565	COG0750	zinc metalloprotease
E4T61_RS08575	COG2176	DNA-directed DNA polymerase activity
E4T61_RS08585	COG0195	Participates in both transcription termination and antitermination
E4T61_RS08590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E4T61_RS08595	COG1358	cellular component organization or biogenesis
E4T61_RS08605	COG1550	Protein conserved in bacteria
E4T61_RS08620	COG0196	riboflavin kinase activity
E4T61_RS08635	COG0726	polysaccharide deacetylase
E4T61_RS08640	COG0612	Peptidase, M16
E4T61_RS08645	COG1873	PFAM PRC-barrel domain
E4T61_RS08650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T61_RS08655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4T61_RS08660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4T61_RS08665	COG0527	aspartate kinase activity
E4T61_RS08675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4T61_RS08680	COG0740	serine-type endopeptidase activity
E4T61_RS08690	COG4980	gas vesicle protein
E4T61_RS08690	COG1674	ftsk spoiiie
E4T61_RS08695	COG2188	Transcriptional regulator
E4T61_RS08700	COG2814	Major facilitator Superfamily
E4T61_RS08705	COG1846	Transcriptional regulator
E4T61_RS08710	COG2409	Drug exporters of the RND superfamily
E4T61_RS08710	COG1033	growth of symbiont in host cell
E4T61_RS08715	COG0612	Peptidase, M16
E4T61_RS08720	COG0612	Peptidase, M16
E4T61_RS08725	COG0300	oxidoreductase activity
E4T61_RS08740	COG1426	Protein conserved in bacteria
E4T61_RS08745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4T61_RS08760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T61_RS08770	COG1692	metallophosphoesterase
E4T61_RS08775	COG2359	stage V sporulation protein S
E4T61_RS08795	COG4550	Control of competence regulator ComK, YlbF/YmcA
E4T61_RS08840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS08845	COG3425	synthase
E4T61_RS08850	COG1024	Enoyl-CoA hydratase
E4T61_RS08855	COG1024	Enoyl-CoA hydratase
E4T61_RS08860	COG3321	synthase
E4T61_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS08860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS08860	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS08860	COG0300	oxidoreductase activity
E4T61_RS08865	COG4221	oxidoreductase activity
E4T61_RS08865	COG3321	synthase
E4T61_RS08865	COG0300	oxidoreductase activity
E4T61_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS08870	COG3321	synthase
E4T61_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS08870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS08870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS08870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS08870	COG3321	synthase
E4T61_RS08870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS08875	COG3321	synthase
E4T61_RS08875	COG4221	oxidoreductase activity
E4T61_RS08875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS08880	COG3321	synthase
E4T61_RS08880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4T61_RS08880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4T61_RS08880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS08885	COG2124	cytochrome p450
E4T61_RS08890	COG3209	COG3209 Rhs family protein
E4T61_RS08895	COG3619	membrane
E4T61_RS08905	COG1404	Belongs to the peptidase S8 family
E4T61_RS08915	COG4195	phage-related replication protein
E4T61_RS08920	COG1764	response to oxidative stress
E4T61_RS08930	COG2076	Multidrug Resistance protein
E4T61_RS08970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T61_RS08975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T61_RS08980	COG4112	unkown
E4T61_RS08985	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS08995	COG0464	growth
E4T61_RS09000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4T61_RS09005	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E4T61_RS09010	COG0789	Transcriptional regulator
E4T61_RS09015	COG0174	glutamine synthetase
E4T61_RS09025	COG2211	Major facilitator Superfamily
E4T61_RS09030	COG3507	Belongs to the glycosyl hydrolase 43 family
E4T61_RS09045	COG1070	Carbohydrate kinase
E4T61_RS09050	COG0574	Belongs to the PEP-utilizing enzyme family
E4T61_RS09050	COG3848	Pyruvate phosphate dikinase
E4T61_RS09075	COG2378	regulation of single-species biofilm formation
E4T61_RS09080	COG2318	DinB family
E4T61_RS09085	COG1064	alcohol dehydrogenase
E4T61_RS09115	COG0456	acetyltransferase
E4T61_RS09150	COG3397	chitin binding
E4T61_RS09175	COG5434	Belongs to the glycosyl hydrolase 28 family
E4T61_RS09180	COG0756	dUTP diphosphatase activity
E4T61_RS09185	COG4195	phage-related replication protein
E4T61_RS09215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T61_RS09225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4T61_RS09245	COG0785	Cytochrome C biogenesis protein
E4T61_RS09250	COG2201	protein-glutamate methylesterase activity
E4T61_RS09255	COG4846	Membrane protein involved in cytochrome C biogenesis
E4T61_RS09265	COG0071	Belongs to the small heat shock protein (HSP20) family
E4T61_RS09280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4T61_RS09285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS09305	COG0824	Thioesterase
E4T61_RS09315	COG4841	protein insertion into membrane
E4T61_RS09325	COG1832	CoA-binding protein
E4T61_RS09330	COG0187	DNA topoisomerase II activity
E4T61_RS09335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4T61_RS09345	COG1115	amino acid carrier protein
E4T61_RS09355	COG1063	alcohol dehydrogenase
E4T61_RS09360	COG0800	Aldolase
E4T61_RS09365	COG1312	Catalyzes the dehydration of D-mannonate
E4T61_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS09375	COG1609	Transcriptional regulator
E4T61_RS09380	COG2271	Major facilitator Superfamily
E4T61_RS09430	COG2205	protein histidine kinase activity
E4T61_RS09435	COG0745	RESPONSE REGULATOR receiver
E4T61_RS09445	COG3507	Belongs to the glycosyl hydrolase 43 family
E4T61_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS09475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4T61_RS09480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T61_RS09485	COG2610	gluconate transmembrane transporter activity
E4T61_RS09490	COG2124	cytochrome p450
E4T61_RS09510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T61_RS09520	COG2246	polysaccharide biosynthetic process
E4T61_RS09525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4T61_RS09530	COG0586	Pfam SNARE associated Golgi protein
E4T61_RS09535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4T61_RS09540	COG1024	Enoyl-CoA hydratase
E4T61_RS09545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T61_RS09550	COG0511	ligase activity, forming carbon-carbon bonds
E4T61_RS09555	COG0439	Biotin carboxylase
E4T61_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS09565	COG1960	acyl-CoA dehydrogenase activity
E4T61_RS09570	COG1649	PFAM Uncharacterised BCR, COG1649
E4T61_RS09580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS09580	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4T61_RS09585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS09590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS09595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS09600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS09610	COG2027	D-alanyl-D-alanine carboxypeptidase
E4T61_RS09615	COG2017	converts alpha-aldose to the beta-anomer
E4T61_RS09620	COG0534	Mate efflux family protein
E4T61_RS09635	COG0582	viral genome integration into host DNA
E4T61_RS09640	COG0166	Belongs to the GPI family
E4T61_RS09645	COG0405	Gamma-glutamyltransferase
E4T61_RS09650	COG2814	Major facilitator Superfamily
E4T61_RS09655	COG0640	Transcriptional regulator
E4T61_RS09660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4T61_RS09670	COG0604	alcohol dehydrogenase
E4T61_RS09675	COG0493	'glutamate synthase
E4T61_RS09680	COG0070	glutamate synthase
E4T61_RS09680	COG0067	glutamate synthase
E4T61_RS09680	COG0069	glutamate synthase activity
E4T61_RS09685	COG0583	DNA-binding transcription factor activity
E4T61_RS09690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4T61_RS09710	COG0300	oxidoreductase activity
E4T61_RS09715	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
E4T61_RS09725	COG2814	Major facilitator Superfamily
E4T61_RS09730	COG1070	Carbohydrate kinase
E4T61_RS09735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T61_RS09740	COG0243	molybdopterin cofactor binding
E4T61_RS09770	COG5444	nuclease activity
E4T61_RS09775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T61_RS09780	COG0662	Cupin 2, conserved barrel domain protein
E4T61_RS09780	COG2207	Transcriptional regulator
E4T61_RS09785	COG1309	transcriptional regulator
E4T61_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS09800	COG0640	Transcriptional regulator
E4T61_RS09805	COG0741	lytic transglycosylase activity
E4T61_RS09810	COG2322	membrane
E4T61_RS09825	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4T61_RS09835	COG3584	3D domain protein
E4T61_RS09835	COG1388	LysM domain
E4T61_RS09840	COG0514	ATP-dependent DNA helicase (RecQ)
E4T61_RS09850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T61_RS09855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T61_RS09870	COG0071	Belongs to the small heat shock protein (HSP20) family
E4T61_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS09905	COG1657	PFAM Prenyltransferase squalene oxidase
E4T61_RS09910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T61_RS09915	COG0733	neurotransmitter:sodium symporter activity
E4T61_RS09920	COG0385	Bile acid
E4T61_RS09925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS09930	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T61_RS09940	COG4548	von Willebrand factor, type A
E4T61_RS09945	COG0714	Associated with various cellular activities
E4T61_RS09950	COG2032	superoxide dismutase activity
E4T61_RS09955	COG0791	NLP P60 protein
E4T61_RS09955	COG1388	LysM domain
E4T61_RS09960	COG1819	glycosyl
E4T61_RS09965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4T61_RS09970	COG0534	Mate efflux family protein
E4T61_RS09975	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS09980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4T61_RS09985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4T61_RS09995	COG2962	Rard protein
E4T61_RS10010	COG1942	4-Oxalocrotonate Tautomerase
E4T61_RS10020	COG1733	regulation of RNA biosynthetic process
E4T61_RS10025	COG0778	Nitroreductase
E4T61_RS10030	COG0400	carboxylic ester hydrolase activity
E4T61_RS10035	COG0346	lactoylglutathione lyase activity
E4T61_RS10045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T61_RS10055	COG2723	6-phospho-beta-galactosidase activity
E4T61_RS10060	COG2188	Transcriptional regulator
E4T61_RS10065	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS10065	COG0793	Belongs to the peptidase S41A family
E4T61_RS10070	COG2226	methyltransferase
E4T61_RS10080	COG1876	peptidase activity
E4T61_RS10100	COG0671	phosphoesterase, PA-phosphatase related
E4T61_RS10130	COG1509	lysine 2,3-aminomutase activity
E4T61_RS10135	COG0456	acetyltransferase
E4T61_RS10140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T61_RS10145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4T61_RS10150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T61_RS10155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T61_RS10170	COG0456	acetyltransferase
E4T61_RS10175	COG0463	Glycosyl transferase, family 2
E4T61_RS10190	COG4641	Protein conserved in bacteria
E4T61_RS10200	COG1086	Polysaccharide biosynthesis protein
E4T61_RS10220	COG1388	LysM domain
E4T61_RS10225	COG0457	Tetratricopeptide repeat
E4T61_RS10235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T61_RS10240	COG3391	amine dehydrogenase activity
E4T61_RS10260	COG5444	nuclease activity
E4T61_RS10265	COG4282	regulation of fungal-type cell wall biogenesis
E4T61_RS10270	COG1525	nuclease
E4T61_RS10275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T61_RS10295	COG1846	Transcriptional regulator
E4T61_RS10300	COG4698	Protein conserved in bacteria
E4T61_RS10305	COG2755	lipolytic protein G-D-S-L family
E4T61_RS10310	COG1999	signal sequence binding
E4T61_RS10320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T61_RS10325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4T61_RS10330	COG1272	protein, Hemolysin III
E4T61_RS10335	COG0204	Acyl-transferase
E4T61_RS10340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4T61_RS10355	COG2136	Putative SAM-dependent methyltransferase
E4T61_RS10355	COG2521	methyltransferase
E4T61_RS10370	COG1413	lyase activity
E4T61_RS10375	COG1418	mRNA catabolic process
E4T61_RS10380	COG0386	Belongs to the glutathione peroxidase family
E4T61_RS10390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4T61_RS10400	COG1278	Cold shock
E4T61_RS10420	COG0328	RNA-DNA hybrid ribonuclease activity
E4T61_RS10425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4T61_RS10430	COG0328	RNA-DNA hybrid ribonuclease activity
E4T61_RS10440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4T61_RS10455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4T61_RS10465	COG1755	Isoprenylcysteine carboxyl methyltransferase
E4T61_RS10470	COG3424	synthase
E4T61_RS10490	COG1335	isochorismatase
E4T61_RS10500	COG2233	PERMEase
E4T61_RS10510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4T61_RS10515	COG1199	ATP-dependent helicase activity
E4T61_RS10530	COG0116	Belongs to the methyltransferase superfamily
E4T61_RS10560	COG3359	exonuclease
E4T61_RS10565	COG1205	dead DEAH box helicase
E4T61_RS10565	COG1111	helicase
E4T61_RS10570	COG2190	(PTS) system
E4T61_RS10575	COG0071	Belongs to the small heat shock protein (HSP20) family
E4T61_RS10615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T61_RS10615	COG4499	WXG100 protein secretion system (Wss), protein YukC
E4T61_RS10625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4T61_RS10630	COG3935	DnaD domain protein
E4T61_RS10640	COG0436	Aminotransferase
E4T61_RS10645	COG5353	protein conserved in bacteria
E4T61_RS10655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T61_RS10655	COG1199	ATP-dependent helicase activity
E4T61_RS10685	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS10690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4T61_RS10705	COG1694	Mazg nucleotide pyrophosphohydrolase
E4T61_RS10710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS10715	COG2140	Oxalate decarboxylase
E4T61_RS10725	COG4347	Protein of unknown function (DUF1405)
E4T61_RS10730	COG2010	Cytochrome c
E4T61_RS10730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4T61_RS10735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4T61_RS10740	COG0723	plastoquinol--plastocyanin reductase activity
E4T61_RS10755	COG0457	Tetratricopeptide repeat
E4T61_RS10765	COG0287	Prephenate dehydrogenase
E4T61_RS10800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4T61_RS10805	COG4401	Chorismate mutase type I
E4T61_RS10820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T61_RS10825	COG0105	UTP biosynthetic process
E4T61_RS10830	COG0142	geranyltranstransferase activity
E4T61_RS10840	COG0142	geranyltranstransferase activity
E4T61_RS10855	COG0776	regulation of translation
E4T61_RS10860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4T61_RS10900	COG0539	negative regulation of cytoplasmic translation
E4T61_RS10910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4T61_RS10915	COG2959	enzyme of heme biosynthesis
E4T61_RS10920	COG3773	Cell wall hydrolase
E4T61_RS10920	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS10925	COG2339	peptidase activity
E4T61_RS10930	COG0492	ferredoxin-NADP+ reductase activity
E4T61_RS10935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4T61_RS10940	COG4862	establishment of competence for transformation
E4T61_RS10945	COG1408	metallophosphoesterase
E4T61_RS10955	COG1388	LysM domain
E4T61_RS10960	COG1266	CAAX protease self-immunity
E4T61_RS10965	COG0514	ATP-dependent DNA helicase (RecQ)
E4T61_RS10970	COG4955	Helix-turn-helix domain
E4T61_RS10975	COG1141	Ferredoxin
E4T61_RS10980	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E4T61_RS10985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T61_RS10995	COG1595	DNA-templated transcription, initiation
E4T61_RS11000	COG5002	protein histidine kinase activity
E4T61_RS11005	COG0745	RESPONSE REGULATOR receiver
E4T61_RS11010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4T61_RS11015	COG1333	cytochrome c biogenesis protein
E4T61_RS11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS11025	COG1187	pseudouridine synthase activity
E4T61_RS11030	COG0700	Nucleoside recognition
E4T61_RS11035	COG2715	membrane protein required for spore maturation
E4T61_RS11040	COG1686	Belongs to the peptidase S11 family
E4T61_RS11065	COG1547	Domain of unknown function (DUF309)
E4T61_RS11075	COG0456	acetyltransferase
E4T61_RS11090	COG0307	riboflavin synthase, alpha
E4T61_RS11095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T61_RS11095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T61_RS11105	COG0681	Belongs to the peptidase S26 family
E4T61_RS11115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4T61_RS11120	COG4086	secreted protein
E4T61_RS11125	COG0019	diaminopimelate decarboxylase activity
E4T61_RS11130	COG0697	spore germination
E4T61_RS11145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4T61_RS11165	COG1191	sigma factor activity
E4T61_RS11175	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS11180	COG1686	Belongs to the peptidase S11 family
E4T61_RS11185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4T61_RS11190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4T61_RS11195	COG4974	Belongs to the 'phage' integrase family
E4T61_RS11205	COG0735	belongs to the Fur family
E4T61_RS11210	COG1300	Membrane
E4T61_RS11225	COG0281	malic enzyme
E4T61_RS11230	COG1757	Na H antiporter
E4T61_RS11235	COG1027	Aspartate ammonia-lyase
E4T61_RS11240	COG0252	asparaginase activity
E4T61_RS11245	COG1396	sequence-specific DNA binding
E4T61_RS11250	COG1379	DNA repair
E4T61_RS11255	COG0494	nUDIX hydrolase
E4T61_RS11265	COG0667	Aldo Keto reductase
E4T61_RS11275	COG1073	alpha beta
E4T61_RS11285	COG4918	Iron-sulphur cluster biosynthesis
E4T61_RS11290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4T61_RS11290	COG0456	acetyltransferase
E4T61_RS11295	COG2329	Antibiotic biosynthesis monooxygenase
E4T61_RS11300	COG0456	acetyltransferase
E4T61_RS11305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T61_RS11320	COG0628	permease
E4T61_RS11330	COG0346	lactoylglutathione lyase activity
E4T61_RS11340	COG3048	D-serine ammonia-lyase activity
E4T61_RS11345	COG0300	oxidoreductase activity
E4T61_RS11350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS11355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4T61_RS11360	COG1024	Enoyl-CoA hydratase
E4T61_RS11365	COG3425	synthase
E4T61_RS11370	COG2124	cytochrome p450
E4T61_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS11375	COG3321	synthase
E4T61_RS11375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS11380	COG3321	synthase
E4T61_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS11380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS11385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11385	COG3321	synthase
E4T61_RS11385	COG0300	oxidoreductase activity
E4T61_RS11385	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS11390	COG0300	oxidoreductase activity
E4T61_RS11390	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS11390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11390	COG3321	synthase
E4T61_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS11395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS11395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11395	COG3321	synthase
E4T61_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11400	COG0300	oxidoreductase activity
E4T61_RS11400	COG3321	synthase
E4T61_RS11400	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS11400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T61_RS11405	COG3321	synthase
E4T61_RS11405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS11415	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS11430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4T61_RS11430	COG2070	2-Nitropropane dioxygenase
E4T61_RS11440	COG0250	Participates in transcription elongation, termination and antitermination
E4T61_RS11465	COG0596	Alpha beta hydrolase
E4T61_RS11480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4T61_RS11485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4T61_RS11500	COG0706	membrane insertase activity
E4T61_RS11505	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4T61_RS11510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4T61_RS11515	COG0346	lactoylglutathione lyase activity
E4T61_RS11520	COG1376	ErfK ybiS ycfS ynhG family protein
E4T61_RS11525	COG4129	membrane
E4T61_RS11530	COG1126	abc transporter atp-binding protein
E4T61_RS11535	COG0765	amino acid transport
E4T61_RS11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS11550	COG1597	lipid kinase activity
E4T61_RS11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T61_RS11560	COG0022	dehydrogenase e1 component
E4T61_RS11565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4T61_RS11570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T61_RS11575	COG3426	butyrate kinase activity
E4T61_RS11580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4T61_RS11585	COG0280	phosphate acetyltransferase
E4T61_RS11590	COG3290	protein histidine kinase activity
E4T61_RS11590	COG3829	transcription factor binding
E4T61_RS11600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4T61_RS11605	COG2079	MmgE PrpD family protein
E4T61_RS11610	COG0372	Belongs to the citrate synthase family
E4T61_RS11615	COG1960	acyl-CoA dehydrogenase activity
E4T61_RS11620	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T61_RS11625	COG0183	Belongs to the thiolase family
E4T61_RS11630	COG0584	glycerophosphoryl diester phosphodiesterase
E4T61_RS11635	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS11660	COG1902	pentaerythritol trinitrate reductase activity
E4T61_RS11675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T61_RS11680	COG0745	RESPONSE REGULATOR receiver
E4T61_RS11685	COG0750	zinc metalloprotease
E4T61_RS11690	COG0497	DNA recombination
E4T61_RS11700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4T61_RS11710	COG0142	geranyltranstransferase activity
E4T61_RS11720	COG1570	exodeoxyribonuclease VII activity
E4T61_RS11735	COG1302	Protein conserved in bacteria
E4T61_RS11740	COG0439	Biotin carboxylase
E4T61_RS11745	COG0511	ligase activity, forming carbon-carbon bonds
E4T61_RS11785	COG3854	ATPases associated with a variety of cellular activities
E4T61_RS11800	COG0006	proline dipeptidase activity
E4T61_RS11810	COG3872	metal-dependent enzyme
E4T61_RS11820	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4T61_RS11835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T61_RS11855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T61_RS11870	COG1396	sequence-specific DNA binding
E4T61_RS11880	COG0681	Belongs to the peptidase S26 family
E4T61_RS11905	COG4940	Competence protein ComGF
E4T61_RS11915	COG4970	Tfp pilus assembly protein FimT
E4T61_RS11920	COG4537	Required for transformation and DNA binding
E4T61_RS11925	COG1459	type II secretion system
E4T61_RS11930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4T61_RS11935	COG0598	Magnesium transport protein CorA
E4T61_RS11940	COG1253	flavin adenine dinucleotide binding
E4T61_RS11945	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS11955	COG1393	Belongs to the ArsC family
E4T61_RS11965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS11975	COG0011	TIGRFAM Protein of
E4T61_RS11985	COG2866	Carboxypeptidase
E4T61_RS11990	COG1940	carbohydrate kinase activity
E4T61_RS11995	COG4483	Protein conserved in bacteria
E4T61_RS12000	COG1757	Na H antiporter
E4T61_RS12010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4T61_RS12025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4T61_RS12030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T61_RS12035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T61_RS12040	COG0581	inorganic phosphate transmembrane transporter activity
E4T61_RS12045	COG0573	inorganic phosphate transmembrane transporter activity
E4T61_RS12050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4T61_RS12055	COG0768	penicillin binding
E4T61_RS12060	COG0477	Major facilitator Superfamily
E4T61_RS12065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T61_RS12070	COG2839	Protein conserved in bacteria
E4T61_RS12075	COG5521	maltodextrose utilization protein MalA
E4T61_RS12080	COG1388	LysM domain
E4T61_RS12090	COG4709	membrane
E4T61_RS12095	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
E4T61_RS12100	COG0735	belongs to the Fur family
E4T61_RS12105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS12120	COG0513	Belongs to the DEAD box helicase family
E4T61_RS12135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4T61_RS12140	COG2384	SAM-dependent methyltransferase
E4T61_RS12145	COG2010	Cytochrome c
E4T61_RS12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4T61_RS12155	COG0358	DNA primase activity
E4T61_RS12170	COG0517	IMP dehydrogenase activity
E4T61_RS12175	COG0751	glycine-tRNA ligase activity
E4T61_RS12195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4T61_RS12200	COG0295	cytidine deaminase activity
E4T61_RS12205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4T61_RS12215	COG1480	7TM receptor with intracellular HD hydrolase
E4T61_RS12220	COG1702	phosphate starvation-inducible protein PhoH
E4T61_RS12225	COG0561	phosphatase activity
E4T61_RS12240	COG4864	UPF0365 protein
E4T61_RS12245	COG1030	water channel activity
E4T61_RS12250	COG1610	YqeY-like protein
E4T61_RS12260	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4T61_RS12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4T61_RS12270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4T61_RS12300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T61_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS12330	COG1466	dna polymerase III delta subunit
E4T61_RS12345	COG0658	competence protein
E4T61_RS12345	COG2333	competence protein COMEC
E4T61_RS12350	COG2131	deaminase
E4T61_RS12355	COG1596	polysaccharide export
E4T61_RS12355	COG1555	photosystem II stabilization
E4T61_RS12360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4T61_RS12365	COG2226	methyltransferase
E4T61_RS12370	COG0799	negative regulation of ribosome biogenesis
E4T61_RS12375	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4T61_RS12385	COG1534	Rna-binding protein
E4T61_RS12390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T61_RS12395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4T61_RS12400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E4T61_RS12410	COG2755	lipolytic protein G-D-S-L family
E4T61_RS12420	COG0398	Pfam SNARE associated Golgi protein
E4T61_RS12465	COG0473	3-isopropylmalate dehydrogenase activity
E4T61_RS12470	COG0563	adenylate kinase activity
E4T61_RS12485	COG5444	nuclease activity
E4T61_RS12515	COG0456	acetyltransferase
E4T61_RS12520	COG2318	DinB family
E4T61_RS12530	COG0561	phosphatase activity
E4T61_RS12535	COG0561	phosphatase activity
E4T61_RS12545	COG1482	cell wall glycoprotein biosynthetic process
E4T61_RS12550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T61_RS12550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T61_RS12550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS12555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS12555	COG3711	transcriptional antiterminator
E4T61_RS12565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4T61_RS12570	COG0583	DNA-binding transcription factor activity
E4T61_RS12575	COG2814	Major facilitator Superfamily
E4T61_RS12580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4T61_RS12580	COG2124	cytochrome p450
E4T61_RS12585	COG1309	transcriptional regulator
E4T61_RS12590	COG2226	methyltransferase
E4T61_RS12605	COG2116	formate transmembrane transporter activity
E4T61_RS12610	COG5609	conserved protein (DUF2294)
E4T61_RS12615	COG3383	formate dehydrogenase (NAD+) activity
E4T61_RS12620	COG2427	Protein of unknown function (DUF1641)
E4T61_RS12630	COG0626	cystathionine gamma-synthase activity
E4T61_RS12635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T61_RS12660	COG0768	penicillin binding
E4T61_RS12675	COG0826	peptidase U32
E4T61_RS12680	COG0826	peptidase U32
E4T61_RS12685	COG4122	O-methyltransferase activity
E4T61_RS12690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4T61_RS12715	COG0628	permease
E4T61_RS12720	COG1126	abc transporter atp-binding protein
E4T61_RS12725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS12730	COG0765	amino acid transport
E4T61_RS12735	COG0765	amino acid transport
E4T61_RS12750	COG3881	PFAM PRC-barrel domain
E4T61_RS12755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4T61_RS12760	COG0457	Tetratricopeptide repeat
E4T61_RS12770	COG1104	cysteine desulfurase activity
E4T61_RS12775	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS12780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4T61_RS12785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4T61_RS12805	COG3103	Sh3 type 3 domain protein
E4T61_RS12805	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS12805	COG4991	sh3 domain protein
E4T61_RS12815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T61_RS12825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4T61_RS12825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4T61_RS12830	COG5416	Lipopolysaccharide assembly protein A domain
E4T61_RS12835	COG0490	domain, Protein
E4T61_RS12840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4T61_RS12840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4T61_RS12850	COG2244	polysaccharide biosynthetic process
E4T61_RS12855	COG2323	membrane
E4T61_RS12865	COG1862	Preprotein translocase
E4T61_RS12910	COG1388	LysM domain
E4T61_RS12920	COG0157	Belongs to the NadC ModD family
E4T61_RS12925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4T61_RS12930	COG1104	cysteine desulfurase activity
E4T61_RS12935	COG1827	regulation of RNA biosynthetic process
E4T61_RS12940	COG0077	Prephenate dehydratase
E4T61_RS12955	COG3290	protein histidine kinase activity
E4T61_RS12960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4T61_RS12965	COG2868	ribosomal protein
E4T61_RS12975	COG1994	Peptidase M50
E4T61_RS12980	COG0739	heme binding
E4T61_RS12985	COG2894	cell division
E4T61_RS12995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4T61_RS13005	COG1077	Cell shape determining protein MreB Mrl
E4T61_RS13025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4T61_RS13030	COG0285	dihydrofolate synthase activity
E4T61_RS13035	COG0525	valine-tRNA ligase activity
E4T61_RS13045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4T61_RS13050	COG1388	LysM domain
E4T61_RS13060	COG0113	porphobilinogen synthase activity
E4T61_RS13065	COG1587	Uroporphyrinogen-III synthase
E4T61_RS13075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4T61_RS13095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T61_RS13100	COG1067	ATP-dependent peptidase activity
E4T61_RS13100	COG0470	DNA polymerase III
E4T61_RS13115	COG1477	protein flavinylation
E4T61_RS13115	COG0457	Tetratricopeptide repeat
E4T61_RS13130	COG0473	3-isopropylmalate dehydrogenase activity
E4T61_RS13145	COG0440	acetolactate synthase activity
E4T61_RS13150	COG0028	Belongs to the TPP enzyme family
E4T61_RS13190	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4T61_RS13210	COG0622	Phosphoesterase
E4T61_RS13215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4T61_RS13225	COG5401	PFAM Sporulation and spore germination
E4T61_RS13235	COG1846	Transcriptional regulator
E4T61_RS13240	COG2197	response regulator
E4T61_RS13245	COG0824	Thioesterase
E4T61_RS13250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4T61_RS13255	COG1053	succinate dehydrogenase
E4T61_RS13260	COG2009	succinate dehydrogenase
E4T61_RS13265	COG1719	4-vinyl reductase, 4VR
E4T61_RS13270	COG0527	aspartate kinase activity
E4T61_RS13285	COG3118	belongs to the thioredoxin family
E4T61_RS13290	COG3534	alpha-L-arabinofuranosidase
E4T61_RS13295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4T61_RS13300	COG2086	electron transfer activity
E4T61_RS13305	COG1024	Enoyl-CoA hydratase
E4T61_RS13310	COG1309	transcriptional regulator
E4T61_RS13315	COG0318	PFAM AMP-dependent synthetase and ligase
E4T61_RS13325	COG3766	membrane
E4T61_RS13335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4T61_RS13335	COG1796	DNA polymerase
E4T61_RS13340	COG1286	toxin biosynthetic process
E4T61_RS13355	COG0072	phenylalanine-tRNA ligase activity
E4T61_RS13355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T61_RS13360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4T61_RS13365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T61_RS13375	COG3835	regulator
E4T61_RS13380	COG0277	FAD linked oxidase domain protein
E4T61_RS13385	COG0247	lactate metabolic process
E4T61_RS13390	COG1966	Carbon starvation protein
E4T61_RS13395	COG3534	alpha-L-arabinofuranosidase
E4T61_RS13400	COG0395	ABC-type sugar transport system, permease component
E4T61_RS13405	COG1175	transmembrane transport
E4T61_RS13410	COG1653	transport
E4T61_RS13420	COG0647	UMP catabolic process
E4T61_RS13425	COG0235	Class ii aldolase
E4T61_RS13430	COG1069	ribulokinase activity
E4T61_RS13435	COG2160	L-arabinose isomerase activity
E4T61_RS13440	COG3507	Belongs to the glycosyl hydrolase 43 family
E4T61_RS13445	COG1363	Peptidase, m42
E4T61_RS13455	COG3326	Membrane
E4T61_RS13470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4T61_RS13475	COG1346	cytolysis
E4T61_RS13480	COG1380	Effector of murein hydrolase LrgA
E4T61_RS13485	COG3279	Response regulator of the LytR AlgR family
E4T61_RS13490	COG3275	phosphorelay sensor kinase activity
E4T61_RS13495	COG1011	Hydrolase
E4T61_RS13510	COG0398	Pfam SNARE associated Golgi protein
E4T61_RS13515	COG1484	DNA-dependent DNA replication
E4T61_RS13520	COG3611	Membrane attachment protein
E4T61_RS13535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T61_RS13540	COG1733	regulation of RNA biosynthetic process
E4T61_RS13545	COG2814	Major facilitator Superfamily
E4T61_RS13550	COG0656	L-ascorbic acid biosynthetic process
E4T61_RS13555	COG0237	dephospho-CoA kinase activity
E4T61_RS13560	COG1971	Probably functions as a manganese efflux pump
E4T61_RS13565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4T61_RS13570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4T61_RS13570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4T61_RS13575	COG5002	protein histidine kinase activity
E4T61_RS13580	COG0745	RESPONSE REGULATOR receiver
E4T61_RS13590	COG0538	isocitrate dehydrogenase activity
E4T61_RS13595	COG0372	Belongs to the citrate synthase family
E4T61_RS13615	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS13625	COG0628	permease
E4T61_RS13630	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4T61_RS13635	COG0469	pyruvate kinase activity
E4T61_RS13655	COG0281	malic enzyme
E4T61_RS13660	COG0587	DNA-directed DNA polymerase activity
E4T61_RS13680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4T61_RS13690	COG4109	DRTGG domain
E4T61_RS13700	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS13715	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T61_RS13725	COG0827	DNA restriction-modification system
E4T61_RS13730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4T61_RS13735	COG3874	Sporulation protein YtfJ
E4T61_RS13745	COG1714	RDD family
E4T61_RS13750	COG0616	signal peptide processing
E4T61_RS13755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4T61_RS13760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4T61_RS13765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T61_RS13780	COG1104	cysteine desulfurase activity
E4T61_RS13785	COG1114	Component of the transport system for branched-chain amino acids
E4T61_RS13795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4T61_RS13800	COG1309	transcriptional regulator
E4T61_RS13805	COG1956	GAF domain-containing protein
E4T61_RS13810	COG2203	Gaf domain
E4T61_RS13810	COG2199	diguanylate cyclase activity
E4T61_RS13825	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS13840	COG1017	nitric oxide dioxygenase activity
E4T61_RS13840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T61_RS13855	COG0693	protein deglycase activity
E4T61_RS13870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4T61_RS13875	COG1378	Sugar-specific transcriptional regulator TrmB
E4T61_RS13905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T61_RS13910	COG0454	-acetyltransferase
E4T61_RS13915	COG0517	IMP dehydrogenase activity
E4T61_RS13920	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4T61_RS13925	COG1360	Flagellar Motor Protein
E4T61_RS13930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4T61_RS13935	COG1609	Transcriptional regulator
E4T61_RS13940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E4T61_RS13940	COG1605	Chorismate mutase
E4T61_RS13945	COG3118	belongs to the thioredoxin family
E4T61_RS13950	COG4980	gas vesicle protein
E4T61_RS13955	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
E4T61_RS13965	COG1674	ftsk spoiiie
E4T61_RS13970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T61_RS13980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS13990	COG1363	Peptidase, m42
E4T61_RS13995	COG5584	Small secreted protein
E4T61_RS14000	COG0281	malic enzyme
E4T61_RS14005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T61_RS14020	COG0510	thiamine kinase activity
E4T61_RS14025	COG1597	lipid kinase activity
E4T61_RS14035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4T61_RS14040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T61_RS14045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T61_RS14050	COG2252	PERMEase
E4T61_RS14055	COG4473	ABC transporter
E4T61_RS14060	COG1131	(ABC) transporter
E4T61_RS14065	COG1349	DNA-binding transcription factor activity
E4T61_RS14070	COG1187	pseudouridine synthase activity
E4T61_RS14075	COG2244	polysaccharide biosynthetic process
E4T61_RS14080	COG2081	HI0933 family
E4T61_RS14090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T61_RS14100	COG1609	Transcriptional regulator
E4T61_RS14105	COG1653	transport
E4T61_RS14110	COG1175	transmembrane transport
E4T61_RS14115	COG0395	ABC-type sugar transport system, permease component
E4T61_RS14120	COG1486	melibiose metabolic process
E4T61_RS14130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T61_RS14145	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T61_RS14145	COG2202	Pas domain
E4T61_RS14150	COG2814	Major facilitator Superfamily
E4T61_RS14155	COG5522	Integral membrane protein (intg_mem_TP0381)
E4T61_RS14160	COG0577	efflux transmembrane transporter activity
E4T61_RS14165	COG1136	(ABC) transporter
E4T61_RS14170	COG2205	protein histidine kinase activity
E4T61_RS14175	COG0745	RESPONSE REGULATOR receiver
E4T61_RS14180	COG0577	efflux transmembrane transporter activity
E4T61_RS14185	COG1136	(ABC) transporter
E4T61_RS14205	COG1131	(ABC) transporter
E4T61_RS14210	COG1725	Transcriptional regulator
E4T61_RS14220	COG1242	4 iron, 4 sulfur cluster binding
E4T61_RS14225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E4T61_RS14235	COG0584	glycerophosphoryl diester phosphodiesterase
E4T61_RS14245	COG2267	carboxylic ester hydrolase activity
E4T61_RS14250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4T61_RS14255	COG1113	amino acid transport
E4T61_RS14260	COG0367	asparagine synthase
E4T61_RS14280	COG1506	peptidase
E4T61_RS14285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T61_RS14290	COG1116	anion transmembrane transporter activity
E4T61_RS14295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T61_RS14300	COG0494	nUDIX hydrolase
E4T61_RS14305	COG4824	toxin secretion phage lysis holin
E4T61_RS14310	COG0783	Belongs to the Dps family
E4T61_RS14335	COG0288	reversible hydration of carbon dioxide
E4T61_RS14345	COG1271	oxidase subunit
E4T61_RS14350	COG1294	oxidase, subunit
E4T61_RS14365	COG4948	Mandelate Racemase Muconate Lactonizing
E4T61_RS14375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4T61_RS14380	COG0596	Alpha beta hydrolase
E4T61_RS14390	COG1169	isochorismate synthase
E4T61_RS14395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T61_RS14400	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E4T61_RS14535	COG3859	Proton-coupled thiamine transporter YuaJ
E4T61_RS14540	COG2268	Band 7 protein
E4T61_RS14545	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4T61_RS14550	COG2318	DinB family
E4T61_RS14560	COG1454	alcohol dehydrogenase
E4T61_RS14565	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS14570	COG1510	regulation of RNA biosynthetic process
E4T61_RS14580	COG0569	domain protein
E4T61_RS14585	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4T61_RS14590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T61_RS14590	COG1017	nitric oxide dioxygenase activity
E4T61_RS14615	COG0628	permease
E4T61_RS14620	COG0673	inositol 2-dehydrogenase activity
E4T61_RS14625	COG0693	protein deglycase activity
E4T61_RS14630	COG0840	transmembrane signaling receptor activity
E4T61_RS14635	COG0840	transmembrane signaling receptor activity
E4T61_RS14640	COG0840	transmembrane signaling receptor activity
E4T61_RS14645	COG0840	transmembrane signaling receptor activity
E4T61_RS14660	COG2070	2-Nitropropane dioxygenase
E4T61_RS14665	COG0432	Pfam Uncharacterised protein family UPF0047
E4T61_RS14670	COG0366	Alpha amylase catalytic
E4T61_RS14675	COG1253	flavin adenine dinucleotide binding
E4T61_RS14680	COG2738	Putative neutral zinc metallopeptidase
E4T61_RS14695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4T61_RS14725	COG1335	isochorismatase
E4T61_RS14730	COG1979	alcohol dehydrogenase
E4T61_RS14735	COG1979	alcohol dehydrogenase
E4T61_RS14740	COG2155	Conserved Protein
E4T61_RS14745	COG1098	S1 RNA binding domain
E4T61_RS14750	COG0436	Aminotransferase
E4T61_RS14755	COG1522	sequence-specific DNA binding
E4T61_RS14760	COG2267	carboxylic ester hydrolase activity
E4T61_RS14770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4T61_RS14775	COG2205	protein histidine kinase activity
E4T61_RS14785	COG5018	Exonuclease
E4T61_RS14790	COG2814	Major facilitator Superfamily
E4T61_RS14795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T61_RS14800	COG3011	Protein conserved in bacteria
E4T61_RS14810	COG3290	protein histidine kinase activity
E4T61_RS14815	COG4565	transcriptional regulatory protein
E4T61_RS14820	COG1744	ABC transporter substrate-binding protein PnrA-like
E4T61_RS14825	COG3845	ABC transporter
E4T61_RS14830	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4T61_RS14835	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4T61_RS14845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4T61_RS14845	COG2111	Na H antiporter
E4T61_RS14850	COG2111	Na H antiporter
E4T61_RS14855	COG1006	Multisubunit Na H antiporter MnhC subunit
E4T61_RS14860	COG0651	ATP synthesis coupled electron transport
E4T61_RS14865	COG1863	multisubunit Na H antiporter MnhE subunit
E4T61_RS14870	COG2212	antiporter activity
E4T61_RS14875	COG1320	monovalent cation:proton antiporter activity
E4T61_RS14880	COG2050	protein possibly involved in aromatic compounds catabolism
E4T61_RS14885	COG2197	response regulator
E4T61_RS14890	COG4585	Histidine kinase
E4T61_RS14900	COG0142	geranyltranstransferase activity
E4T61_RS14920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4T61_RS14925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4T61_RS14930	COG1335	isochorismatase
E4T61_RS14935	COG5506	Protein of unknown function (DUF1694)
E4T61_RS14950	COG0628	permease
E4T61_RS14960	COG1418	mRNA catabolic process
E4T61_RS14965	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS14975	COG1511	domain protein
E4T61_RS14980	COG0433	COG0433 Predicted ATPase
E4T61_RS14980	COG1674	ftsk spoiiie
E4T61_RS14985	COG4499	WXG100 protein secretion system (Wss), protein YukC
E4T61_RS14990	COG5417	Belongs to the EsaB family
E4T61_RS14995	COG4842	Belongs to the WXG100 family
E4T61_RS15000	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E4T61_RS15000	COG2508	Transcriptional regulator
E4T61_RS15005	COG0686	Belongs to the AlaDH PNT family
E4T61_RS15010	COG5634	Uncharacterized conserved protein (DUF2278)
E4T61_RS15015	COG3251	PFAM MbtH domain protein
E4T61_RS15020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T61_RS15025	COG1535	isochorismatase
E4T61_RS15025	COG3433	isochorismatase activity
E4T61_RS15030	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4T61_RS15035	COG1169	isochorismate synthase
E4T61_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS15045	COG2819	hydrolase of the alpha beta superfamily
E4T61_RS15050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4T61_RS15055	COG1268	BioY protein
E4T61_RS15060	COG2056	Na+-H+ antiporter family
E4T61_RS15070	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4T61_RS15075	COG3584	3D domain protein
E4T61_RS15090	COG1252	NADH dehydrogenase
E4T61_RS15120	COG1131	(ABC) transporter
E4T61_RS15145	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E4T61_RS15150	COG0316	Belongs to the HesB IscA family
E4T61_RS15160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T61_RS15170	COG1252	NADH dehydrogenase
E4T61_RS15175	COG4837	Protein of unknown function (DUF1462)
E4T61_RS15180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4T61_RS15185	COG1506	peptidase
E4T61_RS15185	COG4946	Tricorn protease homolog
E4T61_RS15185	COG0823	Involved in the tonB-independent uptake of proteins
E4T61_RS15195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4T61_RS15200	COG0460	homoserine dehydrogenase
E4T61_RS15205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4T61_RS15210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4T61_RS15215	COG0647	UMP catabolic process
E4T61_RS15220	COG2445	Protein of unknown function DUF86
E4T61_RS15225	COG4470	Protein conserved in bacteria
E4T61_RS15240	COG0739	heme binding
E4T61_RS15250	COG0737	Belongs to the 5'-nucleotidase family
E4T61_RS15255	COG0730	response to heat
E4T61_RS15260	COG1801	Protein of unknown function DUF72
E4T61_RS15275	COG2508	Transcriptional regulator
E4T61_RS15280	COG0457	Tetratricopeptide repeat
E4T61_RS15295	COG2814	Major facilitator Superfamily
E4T61_RS15300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4T61_RS15305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T61_RS15310	COG2356	endonuclease I
E4T61_RS15315	COG3842	ATPase activity
E4T61_RS15320	COG2188	Transcriptional regulator
E4T61_RS15325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T61_RS15330	COG0395	ABC-type sugar transport system, permease component
E4T61_RS15335	COG1175	transmembrane transport
E4T61_RS15340	COG1653	transport
E4T61_RS15345	COG2222	sugar isomerase
E4T61_RS15350	COG0789	Transcriptional regulator
E4T61_RS15375	COG0322	excinuclease ABC activity
E4T61_RS15380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T61_RS15385	COG2226	methyltransferase
E4T61_RS15400	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS15405	COG0719	Fe-S assembly protein
E4T61_RS15410	COG0822	iron-sulfur transferase activity
E4T61_RS15415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4T61_RS15420	COG0719	Fe-S assembly protein
E4T61_RS15425	COG0396	ATPase activity
E4T61_RS15435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T61_RS15440	COG1464	Belongs to the NlpA lipoprotein family
E4T61_RS15445	COG2011	ABC-type metal ion transport system permease component
E4T61_RS15450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T61_RS15460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T61_RS15465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E4T61_RS15480	COG1393	Belongs to the ArsC family
E4T61_RS15485	COG1960	acyl-CoA dehydrogenase activity
E4T61_RS15490	COG0183	Belongs to the thiolase family
E4T61_RS15495	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T61_RS15495	COG1024	Enoyl-CoA hydratase
E4T61_RS15515	COG5577	PFAM Coat F domain
E4T61_RS15520	COG1846	Transcriptional regulator
E4T61_RS15525	COG0477	Major facilitator Superfamily
E4T61_RS15530	COG0583	DNA-binding transcription factor activity
E4T61_RS15550	COG1120	ATPase activity
E4T61_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS15570	COG0783	Belongs to the Dps family
E4T61_RS15575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T61_RS15585	COG0745	RESPONSE REGULATOR receiver
E4T61_RS15590	COG2205	protein histidine kinase activity
E4T61_RS15590	COG2770	Histidine kinase
E4T61_RS15600	COG1309	transcriptional regulator
E4T61_RS15605	COG0114	fumarate hydratase activity
E4T61_RS15615	COG0697	spore germination
E4T61_RS15620	COG0814	amino acid
E4T61_RS15630	COG2197	response regulator
E4T61_RS15635	COG4585	Histidine kinase
E4T61_RS15640	COG4758	membrane
E4T61_RS15645	COG3595	metallopeptidase activity
E4T61_RS15650	COG1842	Phage shock protein A
E4T61_RS15655	COG4758	membrane
E4T61_RS15660	COG2814	Major facilitator Superfamily
E4T61_RS15665	COG2096	Adenosyltransferase
E4T61_RS15670	COG1120	ATPase activity
E4T61_RS15675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS15680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T61_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS15690	COG3386	PFAM SMP-30 Gluconolaconase
E4T61_RS15695	COG2205	protein histidine kinase activity
E4T61_RS15700	COG0745	RESPONSE REGULATOR receiver
E4T61_RS15710	COG1191	sigma factor activity
E4T61_RS15720	COG2140	Oxalate decarboxylase
E4T61_RS15730	COG1120	ATPase activity
E4T61_RS15735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS15740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS15745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T61_RS15750	COG0531	amino acid
E4T61_RS15765	COG1988	membrane-bound metal-dependent
E4T61_RS15770	COG1368	sulfuric ester hydrolase activity
E4T61_RS15775	COG1910	domain protein
E4T61_RS15780	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4T61_RS15785	COG4149	molybdate abc transporter
E4T61_RS15790	COG2197	response regulator
E4T61_RS15795	COG3850	Histidine kinase
E4T61_RS15800	COG1131	(ABC) transporter
E4T61_RS15810	COG0842	Transport permease protein
E4T61_RS15815	COG0656	L-ascorbic acid biosynthetic process
E4T61_RS15840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4T61_RS15845	COG3973	AAA domain
E4T61_RS15850	COG2860	membrane
E4T61_RS15860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4T61_RS15865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T61_RS15870	COG2217	Heavy metal translocating P-type atpase
E4T61_RS15875	COG2217	Heavy metal translocating P-type atpase
E4T61_RS15880	COG2608	mercury ion transmembrane transporter activity
E4T61_RS15885	COG1937	Protein conserved in bacteria
E4T61_RS15890	COG0673	inositol 2-dehydrogenase activity
E4T61_RS15910	COG2814	Major facilitator Superfamily
E4T61_RS15925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS15930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4T61_RS15935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS15940	COG1126	abc transporter atp-binding protein
E4T61_RS15945	COG0765	amino acid transport
E4T61_RS15950	COG0765	amino acid transport
E4T61_RS15955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS15960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T61_RS15965	COG0454	-acetyltransferase
E4T61_RS15970	COG0583	DNA-binding transcription factor activity
E4T61_RS15975	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS15980	COG2732	(Barnase) inhibitor
E4T61_RS15995	COG0557	exoribonuclease II activity
E4T61_RS16000	COG1647	Serine aminopeptidase, S33
E4T61_RS16005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4T61_RS16010	COG1476	TRANSCRIPTIONal
E4T61_RS16015	COG1396	sequence-specific DNA binding
E4T61_RS16020	COG1396	sequence-specific DNA binding
E4T61_RS16025	COG1733	regulation of RNA biosynthetic process
E4T61_RS16050	COG1131	(ABC) transporter
E4T61_RS16055	COG1174	glycine betaine transport
E4T61_RS16060	COG1732	Glycine betaine
E4T61_RS16065	COG1174	glycine betaine transport
E4T61_RS16070	COG1125	glycine betaine transport
E4T61_RS16070	COG0517	IMP dehydrogenase activity
E4T61_RS16075	COG1510	regulation of RNA biosynthetic process
E4T61_RS16080	COG1174	glycine betaine transport
E4T61_RS16085	COG1732	Glycine betaine
E4T61_RS16090	COG1174	glycine betaine transport
E4T61_RS16095	COG1125	glycine betaine transport
E4T61_RS16095	COG0517	IMP dehydrogenase activity
E4T61_RS16100	COG1510	regulation of RNA biosynthetic process
E4T61_RS16105	COG2095	MarC family integral membrane protein
E4T61_RS16115	COG3064	Membrane
E4T61_RS16120	COG4640	response to antibiotic
E4T61_RS16125	COG0456	acetyltransferase
E4T61_RS16140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4T61_RS16155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T61_RS16160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T61_RS16165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T61_RS16175	COG2234	aminopeptidase activity
E4T61_RS16195	COG0126	phosphoglycerate kinase activity
E4T61_RS16205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T61_RS16210	COG2390	Transcriptional regulator
E4T61_RS16215	COG2814	Major facilitator Superfamily
E4T61_RS16220	COG1609	Transcriptional regulator
E4T61_RS16225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS16235	COG0583	DNA-binding transcription factor activity
E4T61_RS16240	COG0697	spore germination
E4T61_RS16245	COG1113	amino acid transport
E4T61_RS16255	COG1609	Transcriptional regulator
E4T61_RS16265	COG0561	phosphatase activity
E4T61_RS16270	COG1737	Transcriptional regulator
E4T61_RS16275	COG1070	Carbohydrate kinase
E4T61_RS16300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS16305	COG2186	Transcriptional regulator
E4T61_RS16310	COG1620	l-lactate permease
E4T61_RS16315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4T61_RS16325	COG5039	Polysaccharide pyruvyl transferase
E4T61_RS16330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T61_RS16335	COG0110	maltose O-acetyltransferase activity
E4T61_RS16340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4T61_RS16345	COG2244	polysaccharide biosynthetic process
E4T61_RS16350	COG1216	Glycosyl transferase, family 2
E4T61_RS16355	COG5039	Polysaccharide pyruvyl transferase
E4T61_RS16360	COG1216	Glycosyl transferase, family 2
E4T61_RS16370	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS16375	COG1215	transferase activity, transferring glycosyl groups
E4T61_RS16380	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS16385	COG1086	Polysaccharide biosynthesis protein
E4T61_RS16390	COG0489	protein tyrosine kinase activity
E4T61_RS16395	COG3944	biosynthesis protein
E4T61_RS16400	COG1396	sequence-specific DNA binding
E4T61_RS16405	COG2272	Belongs to the type-B carboxylesterase lipase family
E4T61_RS16415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4T61_RS16420	COG2364	Membrane
E4T61_RS16425	COG0456	acetyltransferase
E4T61_RS16430	COG3479	Phenolic acid decarboxylase
E4T61_RS16485	COG2223	nitrite transmembrane transporter activity
E4T61_RS16490	COG1609	Transcriptional regulator
E4T61_RS16500	COG0583	DNA-binding transcription factor activity
E4T61_RS16505	COG2828	Protein conserved in bacteria
E4T61_RS16510	COG0477	Major facilitator Superfamily
E4T61_RS16510	COG2814	Major facilitator Superfamily
E4T61_RS16515	COG1611	Belongs to the LOG family
E4T61_RS16520	COG1694	Mazg nucleotide pyrophosphohydrolase
E4T61_RS16525	COG0659	secondary active sulfate transmembrane transporter activity
E4T61_RS16530	COG0288	reversible hydration of carbon dioxide
E4T61_RS16540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T61_RS16545	COG4290	ribonuclease
E4T61_RS16550	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E4T61_RS16555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS16565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4T61_RS16575	COG1051	belongs to the nudix hydrolase family
E4T61_RS16580	COG0492	ferredoxin-NADP+ reductase activity
E4T61_RS16585	COG0791	NLP P60 protein
E4T61_RS16585	COG3883	PFAM NLP P60 protein
E4T61_RS16590	COG0457	Tetratricopeptide repeat
E4T61_RS16595	COG5002	protein histidine kinase activity
E4T61_RS16600	COG0745	RESPONSE REGULATOR receiver
E4T61_RS16605	COG1132	(ABC) transporter
E4T61_RS16610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4T61_RS16610	COG0140	phosphoribosyl-ATP diphosphatase activity
E4T61_RS16635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4T61_RS16650	COG4990	cell redox homeostasis
E4T61_RS16655	COG0110	maltose O-acetyltransferase activity
E4T61_RS16675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T61_RS16685	COG2188	Transcriptional regulator
E4T61_RS16690	COG1309	transcriptional regulator
E4T61_RS16695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4T61_RS16700	COG1950	PFAM Membrane protein of
E4T61_RS16705	COG1983	PspC domain protein
E4T61_RS16710	COG3595	metallopeptidase activity
E4T61_RS16725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4T61_RS16735	COG4897	Protein conserved in bacteria
E4T61_RS16740	COG3848	Pyruvate phosphate dikinase
E4T61_RS16740	COG0574	Belongs to the PEP-utilizing enzyme family
E4T61_RS16745	COG1309	transcriptional regulator
E4T61_RS16750	COG2814	Major facilitator Superfamily
E4T61_RS16765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T61_RS16775	COG0793	Belongs to the peptidase S41A family
E4T61_RS16775	COG3409	Peptidoglycan-binding domain 1 protein
E4T61_RS16780	COG3420	alginic acid biosynthetic process
E4T61_RS16785	COG2177	Part of the ABC transporter FtsEX involved in
E4T61_RS16790	COG2884	Cell division ATP-binding protein ftsE
E4T61_RS16795	COG2010	Cytochrome c
E4T61_RS16800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS16815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4T61_RS16830	COG1516	flagellar protein fliS
E4T61_RS16835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4T61_RS16840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4T61_RS16860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4T61_RS16865	COG4786	Flagellar basal body rod
E4T61_RS16865	COG1256	bacterial-type flagellum assembly
E4T61_RS16870	COG3418	PFAM FlgN family protein
E4T61_RS16875	COG2747	anti-sigma28 factor FlgM
E4T61_RS16885	COG1040	competence protein
E4T61_RS16895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E4T61_RS16900	COG1307	EDD domain protein, DegV family
E4T61_RS16905	COG2197	response regulator
E4T61_RS16910	COG4585	Histidine kinase
E4T61_RS16915	COG1739	Uncharacterized protein family UPF0029
E4T61_RS16920	COG1316	TRANSCRIPTIONal
E4T61_RS16925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4T61_RS16930	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS16935	COG1215	transferase activity, transferring glycosyl groups
E4T61_RS16940	COG3206	protein involved in exopolysaccharide biosynthesis
E4T61_RS16945	COG3307	-O-antigen
E4T61_RS16950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4T61_RS16955	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS16955	COG0297	glycogen (starch) synthase activity
E4T61_RS16960	COG2244	polysaccharide biosynthetic process
E4T61_RS16970	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T61_RS16970	COG2247	cell wall binding repeat
E4T61_RS16975	COG2247	cell wall binding repeat
E4T61_RS16975	COG2385	sporulation resulting in formation of a cellular spore
E4T61_RS16985	COG1316	TRANSCRIPTIONal
E4T61_RS16990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4T61_RS16995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4T61_RS17000	COG1134	teichoic acid transport
E4T61_RS17005	COG1682	transport, permease protein
E4T61_RS17010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4T61_RS17020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4T61_RS17025	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E4T61_RS17030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4T61_RS17035	COG4193	domain, Protein
E4T61_RS17040	COG1482	cell wall glycoprotein biosynthetic process
E4T61_RS17045	COG0697	spore germination
E4T61_RS17050	COG0814	amino acid
E4T61_RS17060	COG1215	transferase activity, transferring glycosyl groups
E4T61_RS17065	COG2814	Major facilitator Superfamily
E4T61_RS17070	COG1316	TRANSCRIPTIONal
E4T61_RS17075	COG0561	phosphatase activity
E4T61_RS17080	COG2433	Pfam Transposase IS66
E4T61_RS17085	COG0791	NLP P60 protein
E4T61_RS17095	COG2843	Capsule synthesis protein
E4T61_RS17105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4T61_RS17115	COG0697	spore germination
E4T61_RS17120	COG0814	amino acid
E4T61_RS17130	COG1609	Transcriptional regulator
E4T61_RS17135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T61_RS17145	COG1129	ABC transporter
E4T61_RS17150	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T61_RS17155	COG1879	ABC-type sugar transport system periplasmic component
E4T61_RS17160	COG3103	Sh3 type 3 domain protein
E4T61_RS17165	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T61_RS17170	COG3527	Alpha-acetolactate decarboxylase
E4T61_RS17175	COG0028	Belongs to the TPP enzyme family
E4T61_RS17180	COG0583	DNA-binding transcription factor activity
E4T61_RS17185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T61_RS17200	COG5337	Spore coat protein CotH
E4T61_RS17210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4T61_RS17220	COG0405	Gamma-glutamyltransferase
E4T61_RS17225	COG1522	sequence-specific DNA binding
E4T61_RS17230	COG2059	Chromate
E4T61_RS17235	COG2059	Chromate
E4T61_RS17255	COG5444	nuclease activity
E4T61_RS17270	COG3878	Protein conserved in bacteria
E4T61_RS17275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4T61_RS17280	COG4464	protein tyrosine phosphatase activity
E4T61_RS17285	COG0489	protein tyrosine kinase activity
E4T61_RS17290	COG3944	biosynthesis protein
E4T61_RS17305	COG4715	Zinc finger, swim domain protein
E4T61_RS17310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T61_RS17315	COG0561	phosphatase activity
E4T61_RS17320	COG1349	DNA-binding transcription factor activity
E4T61_RS17325	COG0629	single-stranded DNA binding
E4T61_RS17350	COG0457	Tetratricopeptide repeat
E4T61_RS17355	COG4786	Flagellar basal body rod
E4T61_RS17360	COG4786	Flagellar basal body rod
E4T61_RS17365	COG1077	Cell shape determining protein MreB Mrl
E4T61_RS17370	COG1609	Transcriptional regulator
E4T61_RS17375	COG1846	Transcriptional regulator
E4T61_RS17380	COG2814	Major facilitator Superfamily
E4T61_RS17385	COG1953	Uracil, thiamine, allantoin
E4T61_RS17390	COG0477	Major facilitator Superfamily
E4T61_RS17395	COG1335	isochorismatase
E4T61_RS17400	COG0004	ammonium transporteR
E4T61_RS17405	COG0347	Belongs to the P(II) protein family
E4T61_RS17410	COG0772	Belongs to the SEDS family
E4T61_RS17415	COG0671	phosphoesterase, PA-phosphatase related
E4T61_RS17425	COG0739	heme binding
E4T61_RS17430	COG1247	-acetyltransferase
E4T61_RS17445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T61_RS17460	COG0726	polysaccharide deacetylase
E4T61_RS17470	COG1959	2 iron, 2 sulfur cluster binding
E4T61_RS17485	COG0831	urea catabolic process
E4T61_RS17490	COG3237	CsbD-like
E4T61_RS17495	COG1994	Peptidase M50
E4T61_RS17500	COG0457	Tetratricopeptide repeat
E4T61_RS17510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4T61_RS17515	COG2304	oxidoreductase activity
E4T61_RS17520	COG2304	oxidoreductase activity
E4T61_RS17530	COG2385	sporulation resulting in formation of a cellular spore
E4T61_RS17535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4T61_RS17545	COG4836	Membrane
E4T61_RS17615	COG0698	ribose 5-phosphate isomerase
E4T61_RS17620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T61_RS17630	COG0009	L-threonylcarbamoyladenylate synthase
E4T61_RS17635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4T61_RS17655	COG2890	protein-(glutamine-N5) methyltransferase activity
E4T61_RS17660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4T61_RS17665	COG0346	lactoylglutathione lyase activity
E4T61_RS17670	COG0789	Transcriptional regulator
E4T61_RS17675	COG0679	Auxin Efflux Carrier
E4T61_RS17680	COG0281	malic enzyme
E4T61_RS17695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4T61_RS17700	COG1494	fructose-1,6-bisphosphatase
E4T61_RS17705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4T61_RS17715	COG0191	fructose-bisphosphate aldolase activity
E4T61_RS17720	COG2204	response regulator
E4T61_RS17725	COG4821	SIS domain
E4T61_RS17740	COG0247	lactate metabolic process
E4T61_RS17740	COG2181	nitrate reductase activity
E4T61_RS17745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T61_RS17760	COG1132	(ABC) transporter
E4T61_RS17765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T61_RS17775	COG2181	nitrate reductase activity
E4T61_RS17780	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4T61_RS17785	COG1140	nitrate reductase beta subunit
E4T61_RS17790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4T61_RS17795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T61_RS17805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T61_RS17810	COG2223	nitrite transmembrane transporter activity
E4T61_RS17820	COG4506	Protein conserved in bacteria
E4T61_RS17830	COG3391	amine dehydrogenase activity
E4T61_RS17835	COG3391	amine dehydrogenase activity
E4T61_RS17845	COG0457	Tetratricopeptide repeat
E4T61_RS17890	COG0010	Belongs to the arginase family
E4T61_RS17895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4T61_RS17900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T61_RS17915	COG1994	Peptidase M50
E4T61_RS17920	COG1942	4-Oxalocrotonate Tautomerase
E4T61_RS17925	COG1846	Transcriptional regulator
E4T61_RS17935	COG0531	amino acid
E4T61_RS17940	COG3465	dGTPase activity
E4T61_RS17945	COG1078	dGTPase activity
E4T61_RS17960	COG1695	Transcriptional regulator
E4T61_RS17970	COG1131	(ABC) transporter
E4T61_RS17975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4T61_RS18005	COG0583	DNA-binding transcription factor activity
E4T61_RS18010	COG2855	membrane
E4T61_RS18015	COG0280	phosphate acetyltransferase
E4T61_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS18030	COG0436	Aminotransferase
E4T61_RS18060	COG2814	Major facilitator Superfamily
E4T61_RS18065	COG2814	Major facilitator Superfamily
E4T61_RS18070	COG0833	amino acid
E4T61_RS18075	COG4187	Peptidase family M20/M25/M40
E4T61_RS18080	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS18085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4T61_RS18095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E4T61_RS18100	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4T61_RS18105	COG1088	dTDP-glucose 4,6-dehydratase activity
E4T61_RS18110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4T61_RS18115	COG3980	spore coat polysaccharide biosynthesis protein
E4T61_RS18120	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E4T61_RS18125	COG2089	acid synthase
E4T61_RS18130	COG0456	acetyltransferase
E4T61_RS18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T61_RS18140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4T61_RS18145	COG0463	Glycosyl transferase, family 2
E4T61_RS18155	COG2363	Small membrane protein
E4T61_RS18160	COG2233	PERMEase
E4T61_RS18175	COG1216	Glycosyl transferase, family 2
E4T61_RS18190	COG1695	Transcriptional regulator
E4T61_RS18195	COG0351	phosphomethylpyrimidine kinase
E4T61_RS18205	COG1621	beta-fructofuranosidase activity
E4T61_RS18210	COG1263	PTS System
E4T61_RS18210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS18215	COG3711	transcriptional antiterminator
E4T61_RS18225	COG1404	Belongs to the peptidase S8 family
E4T61_RS18230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T61_RS18235	COG0778	Nitroreductase
E4T61_RS18240	COG0772	Belongs to the SEDS family
E4T61_RS18245	COG0454	-acetyltransferase
E4T61_RS18265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T61_RS18270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T61_RS18275	COG2261	transglycosylase associated protein
E4T61_RS18280	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E4T61_RS18285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4T61_RS18290	COG2246	polysaccharide biosynthetic process
E4T61_RS18295	COG1309	transcriptional regulator
E4T61_RS18315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4T61_RS18320	COG2837	iron assimilation
E4T61_RS18325	COG2822	iron ion transport
E4T61_RS18340	COG0583	DNA-binding transcription factor activity
E4T61_RS18350	COG1346	cytolysis
E4T61_RS18355	COG4895	conserved protein (DUF2196)
E4T61_RS18360	COG0789	Transcriptional regulator
E4T61_RS18365	COG5504	Zn-dependent protease
E4T61_RS18370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T61_RS18375	COG0346	lactoylglutathione lyase activity
E4T61_RS18380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS18385	COG1404	Belongs to the peptidase S8 family
E4T61_RS18390	COG1442	glycosyl transferase family 8
E4T61_RS18395	COG2357	RelA SpoT domain protein
E4T61_RS18400	COG1575	Belongs to the MenA family. Type 1 subfamily
E4T61_RS18425	COG1696	Membrane protein involved in D-alanine export
E4T61_RS18435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E4T61_RS18440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T61_RS18445	COG1486	melibiose metabolic process
E4T61_RS18450	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4T61_RS18455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS18460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS18465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T61_RS18465	COG3711	transcriptional antiterminator
E4T61_RS18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS18485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T61_RS18495	COG0640	Transcriptional regulator
E4T61_RS18500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T61_RS18505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS18510	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4T61_RS18515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T61_RS18520	COG2723	6-phospho-beta-galactosidase activity
E4T61_RS18525	COG1940	carbohydrate kinase activity
E4T61_RS18530	COG1482	cell wall glycoprotein biosynthetic process
E4T61_RS18540	COG0753	catalase activity
E4T61_RS18545	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E4T61_RS18550	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T61_RS18555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4T61_RS18560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4T61_RS18565	COG4988	ABC transporter
E4T61_RS18570	COG1294	oxidase, subunit
E4T61_RS18575	COG1271	oxidase subunit
E4T61_RS18580	COG3493	citrate carrier protein
E4T61_RS18585	COG0726	polysaccharide deacetylase
E4T61_RS18590	COG3842	ATPase activity
E4T61_RS18595	COG2508	Transcriptional regulator
E4T61_RS18600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS18610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4T61_RS18620	COG4894	glucomannan catabolic process
E4T61_RS18625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4T61_RS18630	COG0500	methyltransferase
E4T61_RS18635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T61_RS18650	COG0693	protein deglycase activity
E4T61_RS18650	COG0753	catalase activity
E4T61_RS18655	COG2851	Citrate transporter
E4T61_RS18660	COG2273	Hydrolase Family 16
E4T61_RS18665	COG3711	transcriptional antiterminator
E4T61_RS18670	COG2270	Major facilitator Superfamily
E4T61_RS18675	COG0513	Belongs to the DEAD box helicase family
E4T61_RS18740	COG3209	COG3209 Rhs family protein
E4T61_RS18750	COG0697	spore germination
E4T61_RS18755	COG0589	response to stress
E4T61_RS18760	COG2723	6-phospho-beta-galactosidase activity
E4T61_RS18765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T61_RS18765	COG1263	PTS System
E4T61_RS18765	COG2190	(PTS) system
E4T61_RS18780	COG0494	nUDIX hydrolase
E4T61_RS18785	COG3507	Belongs to the glycosyl hydrolase 43 family
E4T61_RS18810	COG0010	Belongs to the arginase family
E4T61_RS18815	COG0833	amino acid
E4T61_RS18820	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4T61_RS18825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T61_RS18835	COG2390	Transcriptional regulator
E4T61_RS18840	COG0561	phosphatase activity
E4T61_RS18870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T61_RS18875	COG5294	Protein conserved in bacteria
E4T61_RS18880	COG0577	efflux transmembrane transporter activity
E4T61_RS18885	COG1136	(ABC) transporter
E4T61_RS18890	COG2205	protein histidine kinase activity
E4T61_RS18895	COG0745	RESPONSE REGULATOR receiver
E4T61_RS18910	COG1082	Xylose isomerase domain protein TIM barrel
E4T61_RS18920	COG2814	Major facilitator Superfamily
E4T61_RS18950	COG1349	DNA-binding transcription factor activity
E4T61_RS18955	COG0667	Aldo Keto reductase
E4T61_RS18960	COG2814	Major facilitator Superfamily
E4T61_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS18980	COG2197	response regulator
E4T61_RS18985	COG4585	Histidine kinase
E4T61_RS18990	COG3239	Fatty acid desaturase
E4T61_RS19000	COG1309	transcriptional regulator
E4T61_RS19005	COG1012	belongs to the aldehyde dehydrogenase family
E4T61_RS19010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T61_RS19020	COG0640	Transcriptional regulator
E4T61_RS19025	COG2814	Major facilitator Superfamily
E4T61_RS19030	COG1714	RDD family
E4T61_RS19040	COG0450	alkyl hydroperoxide reductase
E4T61_RS19045	COG3634	alkyl hydroperoxide reductase activity
E4T61_RS19050	COG3177	Filamentation induced by cAMP protein fic
E4T61_RS19055	COG1113	amino acid transport
E4T61_RS19065	COG2080	2 iron, 2 sulfur cluster binding
E4T61_RS19080	COG2068	MobA-Related Protein
E4T61_RS19085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T61_RS19105	COG1396	sequence-specific DNA binding
E4T61_RS19155	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E4T61_RS19160	COG0667	Aldo Keto reductase
E4T61_RS19165	COG0456	acetyltransferase
E4T61_RS19170	COG0457	Tetratricopeptide repeat
E4T61_RS19175	COG0010	Belongs to the arginase family
E4T61_RS19180	COG0833	amino acid
E4T61_RS19185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T61_RS19190	COG5658	integral membrane protein
E4T61_RS19195	COG0640	Transcriptional regulator
E4T61_RS19200	COG3829	transcription factor binding
E4T61_RS19210	COG0488	(ABC) transporter
E4T61_RS19225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T61_RS19230	COG5002	protein histidine kinase activity
E4T61_RS19230	COG3850	Histidine kinase
E4T61_RS19235	COG0745	RESPONSE REGULATOR receiver
E4T61_RS19240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T61_RS19245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T61_RS19250	COG4853	Protein conserved in bacteria
E4T61_RS19255	COG4863	YycH protein
E4T61_RS19260	COG5002	protein histidine kinase activity
E4T61_RS19265	COG0745	RESPONSE REGULATOR receiver
E4T61_RS19300	COG0346	lactoylglutathione lyase activity
E4T61_RS19305	COG0305	Participates in initiation and elongation during chromosome replication
E4T61_RS19325	COG3093	addiction module antidote protein HigA
E4T61_RS19330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T61_RS19335	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS19345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4T61_RS19350	COG0438	transferase activity, transferring glycosyl groups
E4T61_RS19370	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E4T61_RS19375	COG4241	membrane
E4T61_RS19385	COG5577	PFAM Coat F domain
E4T61_RS19390	COG1733	regulation of RNA biosynthetic process
E4T61_RS19400	COG0697	spore germination
E4T61_RS19405	COG1621	beta-fructofuranosidase activity
E4T61_RS19410	COG1621	beta-fructofuranosidase activity
E4T61_RS19415	COG1802	Transcriptional regulator
E4T61_RS19420	COG2318	DinB family
E4T61_RS19430	COG0583	DNA-binding transcription factor activity
E4T61_RS19440	COG2814	Major facilitator Superfamily
E4T61_RS19445	COG0583	DNA-binding transcription factor activity
E4T61_RS19455	COG0778	Nitroreductase
E4T61_RS19460	COG1846	Transcriptional regulator
E4T61_RS19465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4T61_RS19470	COG1846	Transcriptional regulator
E4T61_RS19475	COG2153	protein acetylation
E4T61_RS19485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T61_RS19490	COG0583	DNA-binding transcription factor activity
E4T61_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
E4T61_RS19505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T61_RS19510	COG0697	spore germination
E4T61_RS19515	COG1331	Highly conserved protein containing a thioredoxin domain
E4T61_RS19520	COG1266	CAAX protease self-immunity
E4T61_RS19525	COG2814	Major facilitator Superfamily
E4T61_RS19525	COG0477	Major facilitator Superfamily
E4T61_RS19530	COG0346	lactoylglutathione lyase activity
E4T61_RS19535	COG1609	Transcriptional regulator
E4T61_RS19540	COG0708	Exodeoxyribonuclease III
E4T61_RS19545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T61_RS19550	COG2169	Transcriptional regulator
E4T61_RS19560	COG0629	single-stranded DNA binding
E4T61_RS19570	COG0012	GTP binding
E4T61_RS19575	COG0243	molybdopterin cofactor binding
E4T61_RS19580	COG4481	Protein conserved in bacteria
E4T61_RS19585	COG3949	Membrane
E4T61_RS19600	COG1475	DNA binding
E4T61_RS19605	COG1192	Involved in chromosome partitioning
E4T61_RS19630	COG1847	R3H domain protein
E4T61_RS19635	COG0706	membrane insertase activity