locus-tag	class	description
FHE72_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FHE72_RS00010	COG0592	DNA-directed DNA polymerase activity
FHE72_RS00015	COG2501	S4 domain
FHE72_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FHE72_RS00030	COG0187	DNA topoisomerase II activity
FHE72_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FHE72_RS00040	COG2770	Histidine kinase
FHE72_RS00040	COG3437	response regulator, receiver
FHE72_RS00070	COG0386	Belongs to the glutathione peroxidase family
FHE72_RS00080	COG0517	IMP dehydrogenase activity
FHE72_RS00080	COG0516	GMP reductase activity
FHE72_RS00100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FHE72_RS00130	COG1428	Deoxynucleoside kinase
FHE72_RS00135	COG1428	Deoxynucleoside kinase
FHE72_RS00140	COG1388	LysM domain
FHE72_RS00140	COG3858	chitin binding
FHE72_RS00145	COG1335	isochorismatase
FHE72_RS00150	COG0590	tRNA wobble adenosine to inosine editing
FHE72_RS00160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FHE72_RS00165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FHE72_RS00220	COG1982	Orn Lys Arg decarboxylase major
FHE72_RS00230	COG3870	Protein conserved in bacteria
FHE72_RS00235	COG1728	Protein conserved in bacteria
FHE72_RS00240	COG0470	DNA polymerase III
FHE72_RS00245	COG1774	PSP1 C-terminal conserved region
FHE72_RS00250	COG4467	Involved in initiation control of chromosome replication
FHE72_RS00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FHE72_RS00265	COG2002	toxin-antitoxin pair type II binding
FHE72_RS00275	COG0084	hydrolase, TatD family'
FHE72_RS00280	COG3584	3D domain protein
FHE72_RS00280	COG3583	domain protein
FHE72_RS00300	COG4466	Protein conserved in bacteria
FHE72_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHE72_RS00320	COG0251	oxidation-reduction process
FHE72_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FHE72_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FHE72_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FHE72_RS00360	COG2002	toxin-antitoxin pair type II binding
FHE72_RS00365	COG2244	polysaccharide biosynthetic process
FHE72_RS00370	COG3956	TIGRFAM MazG family protein
FHE72_RS00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FHE72_RS00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FHE72_RS00395	COG1098	S1 RNA binding domain
FHE72_RS00415	COG2208	phosphoserine phosphatase activity
FHE72_RS00420	COG2304	oxidoreductase activity
FHE72_RS00425	COG0515	serine threonine protein kinase
FHE72_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FHE72_RS00450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FHE72_RS00455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHE72_RS00460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHE72_RS00470	COG0512	Glutamine amidotransferase of anthranilate synthase
FHE72_RS00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FHE72_RS00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FHE72_RS00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FHE72_RS00495	COG1396	sequence-specific DNA binding
FHE72_RS00585	COG3880	PFAM UvrB UvrC protein
FHE72_RS00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FHE72_RS00595	COG0542	response to heat
FHE72_RS00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FHE72_RS00610	COG4956	integral membrane protein (PIN domain superfamily)
FHE72_RS00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FHE72_RS00620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FHE72_RS00630	COG1045	serine acetyltransferase
FHE72_RS00635	COG0215	cysteine-tRNA ligase activity
FHE72_RS00645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHE72_RS00650	COG3688	RNA-binding protein containing a PIN domain
FHE72_RS00660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FHE72_RS00665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FHE72_RS00670	COG0250	Participates in transcription elongation, termination and antitermination
FHE72_RS00680	COG0081	regulation of translation
FHE72_RS00685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FHE72_RS00695	COG2813	Specifically methylates the guanine in position
FHE72_RS00710	COG1358	cellular component organization or biogenesis
FHE72_RS00715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FHE72_RS00720	COG0049	tRNA binding
FHE72_RS00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FHE72_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FHE72_RS00735	COG0051	transcription antitermination factor activity, RNA binding
FHE72_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FHE72_RS00745	COG0088	Forms part of the polypeptide exit tunnel
FHE72_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FHE72_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FHE72_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FHE72_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FHE72_RS00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FHE72_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
FHE72_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FHE72_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FHE72_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FHE72_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FHE72_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FHE72_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FHE72_RS00830	COG1841	ribosomal large subunit assembly
FHE72_RS00840	COG0201	protein transport
FHE72_RS00845	COG0563	adenylate kinase activity
FHE72_RS00850	COG0024	Methionine aminopeptidase
FHE72_RS00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
FHE72_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FHE72_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FHE72_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FHE72_RS00880	COG0202	RNA polymerase activity
FHE72_RS00885	COG0203	ribosomal protein L17
FHE72_RS00890	COG1122	ATPase activity
FHE72_RS00895	COG1122	ATPase activity
FHE72_RS00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FHE72_RS00905	COG0101	tRNA pseudouridine synthase activity
FHE72_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FHE72_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS00930	COG0489	protein tyrosine kinase activity
FHE72_RS00940	COG2194	sulfuric ester hydrolase activity
FHE72_RS00945	COG0726	polysaccharide deacetylase
FHE72_RS01025	COG1595	DNA-templated transcription, initiation
FHE72_RS01030	COG5662	AntiSigma factor
FHE72_RS01035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FHE72_RS01040	COG4856	YbbR-like protein
FHE72_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHE72_RS01050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHE72_RS01115	COG1132	(ABC) transporter
FHE72_RS01120	COG1132	(ABC) transporter
FHE72_RS01135	COG0019	diaminopimelate decarboxylase activity
FHE72_RS01140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHE72_RS01155	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
FHE72_RS01185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHE72_RS01190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHE72_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FHE72_RS01225	COG0588	phosphoglycerate mutase activity
FHE72_RS01260	COG3944	biosynthesis protein
FHE72_RS01265	COG0489	protein tyrosine kinase activity
FHE72_RS01275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHE72_RS01280	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS01285	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS01290	COG0463	Glycosyl transferase, family 2
FHE72_RS01300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHE72_RS01310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FHE72_RS01315	COG0110	maltose O-acetyltransferase activity
FHE72_RS01320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHE72_RS01325	COG1396	sequence-specific DNA binding
FHE72_RS01330	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS01340	COG1442	glycosyl transferase family 8
FHE72_RS01340	COG1216	Glycosyl transferase, family 2
FHE72_RS01365	COG1132	(ABC) transporter
FHE72_RS01370	COG1132	(ABC) transporter
FHE72_RS01385	COG0367	asparagine synthase
FHE72_RS01395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FHE72_RS01490	COG2861	carbohydrate metabolic process
FHE72_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS01505	COG2814	Major facilitator Superfamily
FHE72_RS01520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHE72_RS01525	COG1115	amino acid carrier protein
FHE72_RS01535	COG0517	IMP dehydrogenase activity
FHE72_RS01540	COG2340	Cysteine-rich secretory protein family
FHE72_RS01550	COG1597	lipid kinase activity
FHE72_RS01555	COG1238	metal cluster binding
FHE72_RS01565	COG0772	Belongs to the SEDS family
FHE72_RS01575	COG1489	DNA binding
FHE72_RS01605	COG0398	Pfam SNARE associated Golgi protein
FHE72_RS01630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FHE72_RS01635	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHE72_RS01640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FHE72_RS01650	COG0513	Belongs to the DEAD box helicase family
FHE72_RS01655	COG4294	response to UV
FHE72_RS01660	COG3402	PFAM membrane-flanked domain
FHE72_RS01665	COG3428	Bacterial PH domain
FHE72_RS01670	COG0705	Rhomboid family
FHE72_RS01675	COG0736	holo-[acyl-carrier-protein] synthase activity
FHE72_RS01680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FHE72_RS01690	COG0864	Transcriptional regulator
FHE72_RS01695	COG2337	Toxic component of a toxin-antitoxin (TA) module
FHE72_RS01700	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS01705	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS01710	COG2172	sigma factor antagonist activity
FHE72_RS01715	COG2208	phosphoserine phosphatase activity
FHE72_RS01720	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS01725	COG2172	sigma factor antagonist activity
FHE72_RS01730	COG1191	sigma factor activity
FHE72_RS01735	COG2208	phosphoserine phosphatase activity
FHE72_RS01835	COG0802	atpase or kinase
FHE72_RS01840	COG1214	PFAM Peptidase M22, glycoprotease
FHE72_RS01845	COG0456	acetyltransferase
FHE72_RS01855	COG0488	(ABC) transporter
FHE72_RS01860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FHE72_RS01865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FHE72_RS01870	COG0805	protein transport
FHE72_RS01880	COG1266	CAAX protease self-immunity
FHE72_RS01885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FHE72_RS01890	COG0459	protein refolding
FHE72_RS01895	COG0582	viral genome integration into host DNA
FHE72_RS01920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FHE72_RS01925	COG0732	type I restriction modification DNA specificity domain
FHE72_RS01930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FHE72_RS01960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FHE72_RS01980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FHE72_RS01990	COG0714	Associated with various cellular activities
FHE72_RS01995	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
FHE72_RS02000	COG1305	Transglutaminase-like
FHE72_RS02005	COG0519	Catalyzes the synthesis of GMP from XMP
FHE72_RS02005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHE72_RS02010	COG2252	PERMEase
FHE72_RS02015	COG3711	transcriptional antiterminator
FHE72_RS02020	COG1263	PTS System
FHE72_RS02020	COG2190	(PTS) system
FHE72_RS02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHE72_RS02040	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FHE72_RS02050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FHE72_RS02055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FHE72_RS02060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FHE72_RS02070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHE72_RS02075	COG0047	phosphoribosylformylglycinamidine synthase activity
FHE72_RS02085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FHE72_RS02095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FHE72_RS02100	COG0138	bifunctional purine biosynthesis protein purh
FHE72_RS02105	COG0151	Belongs to the GarS family
FHE72_RS02120	COG1470	cell adhesion involved in biofilm formation
FHE72_RS02125	COG4496	protein, YerC YecD
FHE72_RS02130	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FHE72_RS02135	COG0210	DNA helicase
FHE72_RS02140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FHE72_RS02145	COG4851	CamS sex pheromone cAM373 precursor
FHE72_RS02150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FHE72_RS02155	COG2224	Isocitrate lyase
FHE72_RS02160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FHE72_RS02165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FHE72_RS02180	COG0505	Belongs to the CarA family
FHE72_RS02185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FHE72_RS02190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FHE72_RS02195	COG5506	Protein of unknown function (DUF1694)
FHE72_RS02215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHE72_RS02220	COG0154	amidase activity
FHE72_RS02260	COG2226	methyltransferase
FHE72_RS02270	COG1597	lipid kinase activity
FHE72_RS02295	COG0166	Belongs to the GPI family
FHE72_RS02310	COG1984	allophanate hydrolase subunit 2
FHE72_RS02315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FHE72_RS02320	COG2814	Major facilitator Superfamily
FHE72_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS02345	COG1131	(ABC) transporter
FHE72_RS02350	COG1725	Transcriptional regulator
FHE72_RS02355	COG1131	(ABC) transporter
FHE72_RS02375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS02385	COG3859	Proton-coupled thiamine transporter YuaJ
FHE72_RS02395	COG2966	Psort location CytoplasmicMembrane, score
FHE72_RS02400	COG3610	response to peptide
FHE72_RS02405	COG0668	transmembrane transport
FHE72_RS02410	COG1132	(ABC) transporter
FHE72_RS02415	COG1132	(ABC) transporter
FHE72_RS02420	COG3871	stress protein (general stress protein 26)
FHE72_RS02435	COG1115	amino acid carrier protein
FHE72_RS02470	COG0584	glycerophosphoryl diester phosphodiesterase
FHE72_RS02475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FHE72_RS02480	COG5002	protein histidine kinase activity
FHE72_RS02485	COG2364	Membrane
FHE72_RS02495	COG2193	ferroxidase activity
FHE72_RS02510	COG1404	Belongs to the peptidase S8 family
FHE72_RS02515	COG2032	superoxide dismutase activity
FHE72_RS02525	COG0733	neurotransmitter:sodium symporter activity
FHE72_RS02530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FHE72_RS02535	COG0488	(ABC) transporter
FHE72_RS02545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS02550	COG1846	Transcriptional regulator
FHE72_RS02555	COG0477	Major facilitator Superfamily
FHE72_RS02565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FHE72_RS02585	COG2151	metal-sulfur cluster biosynthetic enzyme
FHE72_RS02595	COG1024	Enoyl-CoA hydratase
FHE72_RS02600	COG1024	Enoyl-CoA hydratase
FHE72_RS02605	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS02610	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHE72_RS02625	COG3327	negative regulation of DNA-templated transcription, initiation
FHE72_RS02640	COG4120	Belongs to the binding-protein-dependent transport system permease family
FHE72_RS02645	COG1122	ATPase activity
FHE72_RS02665	COG0022	dehydrogenase e1 component
FHE72_RS02680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FHE72_RS02690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FHE72_RS02695	COG0179	Fumarylacetoacetate (FAA) hydrolase
FHE72_RS02705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FHE72_RS02715	COG0028	Belongs to the TPP enzyme family
FHE72_RS02720	COG0440	acetolactate synthase activity
FHE72_RS02725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FHE72_RS02730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FHE72_RS02745	COG0066	3-isopropylmalate dehydratase activity
FHE72_RS02755	COG0460	homoserine dehydrogenase
FHE72_RS02760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FHE72_RS02765	COG0083	homoserine kinase activity
FHE72_RS02775	COG3852	Histidine kinase
FHE72_RS02785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FHE72_RS02800	COG0210	DNA helicase
FHE72_RS02805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FHE72_RS02835	COG2610	gluconate transmembrane transporter activity
FHE72_RS02840	COG1070	Carbohydrate kinase
FHE72_RS02845	COG0217	transcriptional regulatory protein
FHE72_RS02875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FHE72_RS02885	COG0702	epimerase
FHE72_RS02890	COG1309	transcriptional regulator
FHE72_RS02895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHE72_RS02900	COG1609	Transcriptional regulator
FHE72_RS02915	COG0395	ABC-type sugar transport system, permease component
FHE72_RS02920	COG2723	6-phospho-beta-galactosidase activity
FHE72_RS02930	COG2244	polysaccharide biosynthetic process
FHE72_RS02970	COG2197	response regulator
FHE72_RS02990	COG0714	Associated with various cellular activities
FHE72_RS03030	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS03035	COG2130	NADP-dependent
FHE72_RS03045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS03055	COG0456	acetyltransferase
FHE72_RS03065	COG0288	reversible hydration of carbon dioxide
FHE72_RS03085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS03095	COG0488	(ABC) transporter
FHE72_RS03100	COG2081	HI0933 family
FHE72_RS03110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FHE72_RS03135	COG1595	DNA-templated transcription, initiation
FHE72_RS03140	COG1077	Cell shape determining protein MreB Mrl
FHE72_RS03145	COG0840	transmembrane signaling receptor activity
FHE72_RS03155	COG1607	acyl-coa hydrolase
FHE72_RS03160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FHE72_RS03165	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHE72_RS03195	COG2309	aminopeptidase activity
FHE72_RS03205	COG1959	2 iron, 2 sulfur cluster binding
FHE72_RS03230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FHE72_RS03235	COG1360	Flagellar Motor Protein
FHE72_RS03240	COG1115	amino acid carrier protein
FHE72_RS03245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHE72_RS03250	COG2313	pseudouridylate synthase activity
FHE72_RS03255	COG5002	protein histidine kinase activity
FHE72_RS03260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FHE72_RS03270	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FHE72_RS03275	COG0693	protein deglycase activity
FHE72_RS03280	COG4840	Belongs to the UPF0435 family
FHE72_RS03290	COG1295	ribonuclease BN
FHE72_RS03295	COG3275	phosphorelay sensor kinase activity
FHE72_RS03300	COG3279	Response regulator of the LytR AlgR family
FHE72_RS03305	COG1966	Carbon starvation protein
FHE72_RS03325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FHE72_RS03355	COG0069	glutamate synthase activity
FHE72_RS03360	COG0028	Belongs to the TPP enzyme family
FHE72_RS03370	COG1263	PTS System
FHE72_RS03370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHE72_RS03370	COG2190	(PTS) system
FHE72_RS03375	COG2217	Heavy metal translocating P-type atpase
FHE72_RS03380	COG0477	Major facilitator Superfamily
FHE72_RS03390	COG3871	stress protein (general stress protein 26)
FHE72_RS03395	COG0387	Pfam Sodium calcium exchanger
FHE72_RS03420	COG0535	radical SAM domain protein
FHE72_RS03450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FHE72_RS03455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHE72_RS03460	COG1902	pentaerythritol trinitrate reductase activity
FHE72_RS03475	COG0861	Integral membrane protein TerC family
FHE72_RS03510	COG1131	(ABC) transporter
FHE72_RS03525	COG2186	Transcriptional regulator
FHE72_RS03530	COG1846	Transcriptional regulator
FHE72_RS03535	COG1033	growth of symbiont in host cell
FHE72_RS03535	COG2409	Drug exporters of the RND superfamily
FHE72_RS03540	COG0579	oxidoreductase
FHE72_RS03560	COG1472	Belongs to the glycosyl hydrolase 3 family
FHE72_RS03565	COG1346	cytolysis
FHE72_RS03570	COG1380	Effector of murein hydrolase LrgA
FHE72_RS03575	COG1846	Transcriptional regulator
FHE72_RS03585	COG1309	transcriptional regulator
FHE72_RS03610	COG1349	DNA-binding transcription factor activity
FHE72_RS03625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS03660	COG1132	(ABC) transporter
FHE72_RS03665	COG0412	Dienelactone hydrolase
FHE72_RS03670	COG2304	oxidoreductase activity
FHE72_RS03685	COG1742	UPF0060 membrane protein
FHE72_RS03700	COG0730	response to heat
FHE72_RS03710	COG1846	Transcriptional regulator
FHE72_RS03755	COG0546	phosphoglycolate phosphatase activity
FHE72_RS03760	COG0702	epimerase
FHE72_RS03790	COG3773	Cell wall hydrolase
FHE72_RS03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHE72_RS03815	COG1051	belongs to the nudix hydrolase family
FHE72_RS03845	COG1595	DNA-templated transcription, initiation
FHE72_RS03875	COG0572	uridine kinase
FHE72_RS03900	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
FHE72_RS03960	COG2226	methyltransferase
FHE72_RS03965	COG0583	DNA-binding transcription factor activity
FHE72_RS03970	COG1607	acyl-coa hydrolase
FHE72_RS03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHE72_RS03985	COG2602	Beta-lactamase
FHE72_RS04020	COG2814	Major facilitator Superfamily
FHE72_RS04050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FHE72_RS04065	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS04095	COG3634	alkyl hydroperoxide reductase activity
FHE72_RS04100	COG0450	alkyl hydroperoxide reductase
FHE72_RS04110	COG2814	Major facilitator Superfamily
FHE72_RS04135	COG0697	spore germination
FHE72_RS04165	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FHE72_RS04175	COG0697	spore germination
FHE72_RS04185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FHE72_RS04210	COG3344	reverse transcriptase
FHE72_RS04235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS04240	COG1846	Transcriptional regulator
FHE72_RS04245	COG0456	acetyltransferase
FHE72_RS04250	COG2808	Putative FMN-binding domain
FHE72_RS04260	COG2318	DinB family
FHE72_RS04285	COG0789	Transcriptional regulator
FHE72_RS04290	COG1064	alcohol dehydrogenase
FHE72_RS04295	COG0110	maltose O-acetyltransferase activity
FHE72_RS04315	COG2376	Dihydroxyacetone kinase
FHE72_RS04330	COG1525	nuclease
FHE72_RS04365	COG1175	transmembrane transport
FHE72_RS04370	COG3833	ABC-type maltose transport systems, permease component
FHE72_RS04385	COG4753	response regulator
FHE72_RS04385	COG2207	Transcriptional regulator
FHE72_RS04400	COG0673	inositol 2-dehydrogenase activity
FHE72_RS04455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHE72_RS04490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHE72_RS04545	COG1396	sequence-specific DNA binding
FHE72_RS04580	COG0494	nUDIX hydrolase
FHE72_RS04610	COG0305	Participates in initiation and elongation during chromosome replication
FHE72_RS04630	COG5505	Protein of unknown function (DUF819)
FHE72_RS04650	COG0714	Associated with various cellular activities
FHE72_RS04680	COG1233	COG1233 Phytoene dehydrogenase and related
FHE72_RS04695	COG0726	polysaccharide deacetylase
FHE72_RS04700	COG1609	Transcriptional regulator
FHE72_RS04710	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FHE72_RS04715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FHE72_RS04725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FHE72_RS04745	COG2153	protein acetylation
FHE72_RS04750	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS04800	COG0346	lactoylglutathione lyase activity
FHE72_RS04825	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FHE72_RS04855	COG2211	Major facilitator Superfamily
FHE72_RS04875	COG0456	acetyltransferase
FHE72_RS04930	COG1846	Transcriptional regulator
FHE72_RS04945	COG0477	Major facilitator Superfamily
FHE72_RS04965	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS04970	COG2205	protein histidine kinase activity
FHE72_RS04980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS05010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHE72_RS05020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHE72_RS05025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHE72_RS05030	COG0745	RESPONSE REGULATOR receiver
FHE72_RS05035	COG3850	Histidine kinase
FHE72_RS05035	COG5002	protein histidine kinase activity
FHE72_RS05045	COG2323	membrane
FHE72_RS05070	COG2814	Major facilitator Superfamily
FHE72_RS05075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS05080	COG2323	membrane
FHE72_RS05085	COG1063	alcohol dehydrogenase
FHE72_RS05095	COG2323	membrane
FHE72_RS05110	COG3546	catalase activity
FHE72_RS05125	COG2832	Protein of unknown function (DUF454)
FHE72_RS05155	COG1595	DNA-templated transcription, initiation
FHE72_RS05185	COG2814	Major facilitator Superfamily
FHE72_RS05200	COG2746	aminoglycoside 3-N-acetyltransferase activity
FHE72_RS05230	COG1131	(ABC) transporter
FHE72_RS05235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FHE72_RS05250	COG3037	sugar-specific permease SgaT UlaA
FHE72_RS05260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHE72_RS05260	COG3711	transcriptional antiterminator
FHE72_RS05310	COG0494	nUDIX hydrolase
FHE72_RS05325	COG0640	Transcriptional regulator
FHE72_RS05330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FHE72_RS05335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHE72_RS05350	COG0640	Transcriptional regulator
FHE72_RS05355	COG0589	response to stress
FHE72_RS05360	COG0659	secondary active sulfate transmembrane transporter activity
FHE72_RS05370	COG5646	InterPro IPR014922
FHE72_RS05375	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FHE72_RS05380	COG0726	polysaccharide deacetylase
FHE72_RS05400	COG2814	Major facilitator Superfamily
FHE72_RS05405	COG1309	transcriptional regulator
FHE72_RS05450	COG0590	tRNA wobble adenosine to inosine editing
FHE72_RS05455	COG0572	uridine kinase
FHE72_RS05460	COG5002	protein histidine kinase activity
FHE72_RS05485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS05505	COG0124	histidyl-tRNA synthetase
FHE72_RS05515	COG2814	Major facilitator Superfamily
FHE72_RS05525	COG3344	reverse transcriptase
FHE72_RS05535	COG3655	Transcriptional regulator
FHE72_RS05540	COG3739	integral membrane protein
FHE72_RS05575	COG1393	Belongs to the ArsC family
FHE72_RS05600	COG1132	(ABC) transporter
FHE72_RS05610	COG4221	oxidoreductase activity
FHE72_RS05615	COG0789	Transcriptional regulator
FHE72_RS05640	COG0367	asparagine synthase
FHE72_RS05645	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS05665	COG2213	PTS system mannitol-specific
FHE72_RS05665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHE72_RS05670	COG3711	transcriptional antiterminator
FHE72_RS05675	COG0246	Mannitol dehydrogenase
FHE72_RS05685	COG0697	spore germination
FHE72_RS05690	COG0019	diaminopimelate decarboxylase activity
FHE72_RS05705	COG1404	Belongs to the peptidase S8 family
FHE72_RS05720	COG0583	DNA-binding transcription factor activity
FHE72_RS05725	COG1511	domain protein
FHE72_RS05740	COG0501	Belongs to the peptidase M48B family
FHE72_RS05745	COG5632	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS05750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHE72_RS05770	COG1113	amino acid transport
FHE72_RS05790	COG1309	transcriptional regulator
FHE72_RS05810	COG0833	amino acid
FHE72_RS05815	COG2040	homocysteine
FHE72_RS05820	COG3459	Glycosyltransferase 36 associated
FHE72_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS05845	COG3239	Fatty acid desaturase
FHE72_RS05850	COG2197	response regulator
FHE72_RS05860	COG0306	phosphate transporter
FHE72_RS05865	COG1392	Phosphate transport regulator
FHE72_RS05870	COG1187	pseudouridine synthase activity
FHE72_RS05875	COG0789	Transcriptional regulator
FHE72_RS05885	COG1278	Cold shock
FHE72_RS05895	COG1278	Cold shock
FHE72_RS05910	COG1609	Transcriptional regulator
FHE72_RS05930	COG0395	ABC-type sugar transport system, permease component
FHE72_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS05955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FHE72_RS05980	COG1115	amino acid carrier protein
FHE72_RS05990	COG2188	Transcriptional regulator
FHE72_RS06005	COG3300	MHYT domain
FHE72_RS06005	COG5001	Diguanylate cyclase
FHE72_RS06020	COG3189	MarR family transcriptional regulator
FHE72_RS06025	COG1136	(ABC) transporter
FHE72_RS06045	COG1280	lysine exporter protein (LysE YggA)
FHE72_RS06065	COG1114	Component of the transport system for branched-chain amino acids
FHE72_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS06080	COG0604	alcohol dehydrogenase
FHE72_RS06085	COG1395	domain, Protein
FHE72_RS06105	COG3832	glyoxalase III activity
FHE72_RS06110	COG2207	Transcriptional regulator
FHE72_RS06110	COG3708	Transcriptional regulator
FHE72_RS06120	COG2186	Transcriptional regulator
FHE72_RS06125	COG1620	l-lactate permease
FHE72_RS06130	COG0247	lactate metabolic process
FHE72_RS06135	COG1139	Iron-sulfur cluster binding protein
FHE72_RS06140	COG1556	Lactate utilization protein
FHE72_RS06165	COG1136	(ABC) transporter
FHE72_RS06170	COG0577	efflux transmembrane transporter activity
FHE72_RS06175	COG3850	Histidine kinase
FHE72_RS06175	COG5002	protein histidine kinase activity
FHE72_RS06210	COG2205	protein histidine kinase activity
FHE72_RS06215	COG0778	Nitroreductase
FHE72_RS06225	COG1918	ferrous iron import across plasma membrane
FHE72_RS06225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FHE72_RS06230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FHE72_RS06245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FHE72_RS06260	COG0277	FAD linked oxidase domain protein
FHE72_RS06270	COG2971	BadF BadG BcrA BcrD
FHE72_RS06280	COG1447	Phosphotransferase system cellobiose-specific component IIA
FHE72_RS06285	COG1737	Transcriptional regulator
FHE72_RS06295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHE72_RS06305	COG1486	melibiose metabolic process
FHE72_RS06310	COG0697	spore germination
FHE72_RS06315	COG5553	Cysteine dioxygenase type I
FHE72_RS06320	COG1649	PFAM Uncharacterised BCR, COG1649
FHE72_RS06325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FHE72_RS06345	COG0493	'glutamate synthase
FHE72_RS06360	COG1657	PFAM Prenyltransferase squalene oxidase
FHE72_RS06370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FHE72_RS06410	COG3290	protein histidine kinase activity
FHE72_RS06415	COG4565	transcriptional regulatory protein
FHE72_RS06420	COG3181	Tripartite tricarboxylate transporter family receptor
FHE72_RS06435	COG1053	succinate dehydrogenase
FHE72_RS06445	COG1607	acyl-coa hydrolase
FHE72_RS06450	COG2268	Band 7 protein
FHE72_RS06455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FHE72_RS06475	COG0737	Belongs to the 5'-nucleotidase family
FHE72_RS06490	COG0277	FAD linked oxidase domain protein
FHE72_RS06495	COG0385	Bile acid
FHE72_RS06500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHE72_RS06510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FHE72_RS06515	COG1120	ATPase activity
FHE72_RS06525	COG0861	Integral membrane protein TerC family
FHE72_RS06550	COG0697	spore germination
FHE72_RS06565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FHE72_RS06570	COG2270	Major facilitator Superfamily
FHE72_RS06580	COG1664	Polymer-forming cytoskeletal
FHE72_RS06585	COG0789	Transcriptional regulator
FHE72_RS06600	COG0542	response to heat
FHE72_RS06610	COG0561	phosphatase activity
FHE72_RS06635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FHE72_RS06660	COG1090	epimerase
FHE72_RS06675	COG0300	oxidoreductase activity
FHE72_RS06700	COG1988	membrane-bound metal-dependent
FHE72_RS06710	COG1194	a g-specific adenine glycosylase
FHE72_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS06735	COG3557	Belongs to the UPF0374 family
FHE72_RS06740	COG1132	(ABC) transporter
FHE72_RS06745	COG0444	Belongs to the ABC transporter superfamily
FHE72_RS06750	COG4608	Belongs to the ABC transporter superfamily
FHE72_RS06755	COG0747	negative chemotaxis
FHE72_RS06770	COG4129	membrane
FHE72_RS06775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FHE72_RS06780	COG4555	ABC transporter
FHE72_RS06800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FHE72_RS06810	COG2096	Adenosyltransferase
FHE72_RS06815	COG0735	belongs to the Fur family
FHE72_RS06940	COG2972	Histidine kinase
FHE72_RS06945	COG4753	response regulator
FHE72_RS06945	COG2207	Transcriptional regulator
FHE72_RS06970	COG3382	B3 4 domain protein
FHE72_RS06975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FHE72_RS06985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FHE72_RS06990	COG0778	Nitroreductase
FHE72_RS06995	COG2766	serine protein kinase
FHE72_RS07020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FHE72_RS07025	COG0673	inositol 2-dehydrogenase activity
FHE72_RS07040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FHE72_RS07050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FHE72_RS07055	COG2249	NAD(P)H dehydrogenase (quinone) activity
FHE72_RS07070	COG0039	L-malate dehydrogenase activity
FHE72_RS07080	COG0406	alpha-ribazole phosphatase activity
FHE72_RS07085	COG2252	PERMEase
FHE72_RS07090	COG4187	Peptidase family M20/M25/M40
FHE72_RS07095	COG4988	ABC transporter
FHE72_RS07100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FHE72_RS07105	COG0778	Nitroreductase
FHE72_RS07115	COG1609	Transcriptional regulator
FHE72_RS07120	COG1970	mechanosensitive ion channel activity
FHE72_RS07130	COG2205	protein histidine kinase activity
FHE72_RS07135	COG3973	AAA domain
FHE72_RS07140	COG0656	L-ascorbic acid biosynthetic process
FHE72_RS07145	COG2259	Doxx family
FHE72_RS07150	COG0655	NAD(P)H dehydrogenase (quinone) activity
FHE72_RS07155	COG0564	pseudouridine synthase activity
FHE72_RS07170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FHE72_RS07180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FHE72_RS07180	COG3153	acetyltransferase
FHE72_RS07185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHE72_RS07190	COG2203	Gaf domain
FHE72_RS07190	COG4585	Histidine kinase
FHE72_RS07195	COG2197	response regulator
FHE72_RS07200	COG0431	NADPH-dependent FMN reductase
FHE72_RS07220	COG2719	SpoVR family
FHE72_RS07240	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS07250	COG1253	flavin adenine dinucleotide binding
FHE72_RS07270	COG4989	oxidoreductase activity
FHE72_RS07280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHE72_RS07290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHE72_RS07300	COG0084	hydrolase, TatD family'
FHE72_RS07320	COG1301	dicarboxylic acid transport
FHE72_RS07325	COG2249	NAD(P)H dehydrogenase (quinone) activity
FHE72_RS07335	COG0415	Belongs to the DNA photolyase family
FHE72_RS07345	COG0589	response to stress
FHE72_RS07355	COG1288	antiporter activity
FHE72_RS07360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FHE72_RS07370	COG1595	DNA-templated transcription, initiation
FHE72_RS07385	COG1132	(ABC) transporter
FHE72_RS07390	COG1132	(ABC) transporter
FHE72_RS07400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FHE72_RS07405	COG0702	epimerase
FHE72_RS07410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHE72_RS07415	COG0765	amino acid transport
FHE72_RS07420	COG1126	abc transporter atp-binding protein
FHE72_RS07425	COG0114	fumarate hydratase activity
FHE72_RS07440	COG3842	ATPase activity
FHE72_RS07445	COG2508	Transcriptional regulator
FHE72_RS07450	COG1937	Protein conserved in bacteria
FHE72_RS07475	COG0189	ligase activity
FHE72_RS07485	COG0189	ligase activity
FHE72_RS07490	COG4399	Belongs to the UPF0754 family
FHE72_RS07500	COG0561	phosphatase activity
FHE72_RS07505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FHE72_RS07510	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS07515	COG1024	Enoyl-CoA hydratase
FHE72_RS07525	COG4152	abc transporter atp-binding protein
FHE72_RS07530	COG1668	transmembrane transport
FHE72_RS07535	COG0420	3'-5' exonuclease activity
FHE72_RS07540	COG4717	serine-type aminopeptidase activity
FHE72_RS07545	COG3481	metal-dependent phosphohydrolase, HD sub domain
FHE72_RS07555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHE72_RS07590	COG1846	Transcriptional regulator
FHE72_RS07610	COG0537	adenosine 5'-monophosphoramidase activity
FHE72_RS07615	COG1131	(ABC) transporter
FHE72_RS07620	COG4473	ABC transporter
FHE72_RS07635	COG1473	amidohydrolase
FHE72_RS07645	COG3069	C4-dicarboxylate transmembrane transporter activity
FHE72_RS07655	COG4585	Histidine kinase
FHE72_RS07660	COG2197	response regulator
FHE72_RS07670	COG2329	Antibiotic biosynthesis monooxygenase
FHE72_RS07675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FHE72_RS07690	COG3858	chitin binding
FHE72_RS07690	COG1388	LysM domain
FHE72_RS07695	COG1309	transcriptional regulator
FHE72_RS07700	COG1511	domain protein
FHE72_RS07715	COG1234	tRNA 3'-trailer cleavage
FHE72_RS07720	COG0095	Lipoate-protein ligase
FHE72_RS07735	COG1024	Enoyl-CoA hydratase
FHE72_RS07740	COG3290	protein histidine kinase activity
FHE72_RS07745	COG4565	transcriptional regulatory protein
FHE72_RS07760	COG2391	methyltransferase activity
FHE72_RS07765	COG5337	Spore coat protein CotH
FHE72_RS07770	COG1396	sequence-specific DNA binding
FHE72_RS07775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FHE72_RS07785	COG0501	Belongs to the peptidase M48B family
FHE72_RS07795	COG2323	membrane
FHE72_RS07815	COG4946	Tricorn protease homolog
FHE72_RS07815	COG1506	peptidase
FHE72_RS07815	COG0823	Involved in the tonB-independent uptake of proteins
FHE72_RS07820	COG0398	Pfam SNARE associated Golgi protein
FHE72_RS07830	COG2909	trisaccharide binding
FHE72_RS07835	COG2770	Histidine kinase
FHE72_RS07835	COG3437	response regulator, receiver
FHE72_RS07845	COG0411	ABC transporter
FHE72_RS07855	COG0559	Belongs to the binding-protein-dependent transport system permease family
FHE72_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS07885	COG2356	endonuclease I
FHE72_RS07890	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS07905	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FHE72_RS07915	COG1403	HNH endonuclease
FHE72_RS07950	COG2311	Membrane
FHE72_RS07955	COG0179	Fumarylacetoacetate (FAA) hydrolase
FHE72_RS07970	COG0367	asparagine synthase
FHE72_RS07990	COG0004	ammonium transporteR
FHE72_RS07995	COG0347	Belongs to the P(II) protein family
FHE72_RS08000	COG0534	Mate efflux family protein
FHE72_RS08010	COG2182	Extracellular solute-binding protein
FHE72_RS08015	COG1175	transmembrane transport
FHE72_RS08020	COG3833	ABC-type maltose transport systems, permease component
FHE72_RS08025	COG1874	Beta-galactosidase
FHE72_RS08025	COG0366	Alpha amylase catalytic
FHE72_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS08040	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHE72_RS08045	COG1666	GTP binding
FHE72_RS08055	COG1307	EDD domain protein, DegV family
FHE72_RS08060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS08075	COG0561	phosphatase activity
FHE72_RS08085	COG2151	metal-sulfur cluster biosynthetic enzyme
FHE72_RS08090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHE72_RS08115	COG2267	carboxylic ester hydrolase activity
FHE72_RS08125	COG1744	ABC transporter substrate-binding protein PnrA-like
FHE72_RS08135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FHE72_RS08140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FHE72_RS08160	COG0180	Tryptophanyl-tRNA synthetase
FHE72_RS08170	COG4166	transmembrane transport
FHE72_RS08175	COG0601	transmembrane transport
FHE72_RS08180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHE72_RS08185	COG0444	Belongs to the ABC transporter superfamily
FHE72_RS08190	COG4608	Belongs to the ABC transporter superfamily
FHE72_RS08200	COG0456	acetyltransferase
FHE72_RS08205	COG1393	Belongs to the ArsC family
FHE72_RS08210	COG4862	establishment of competence for transformation
FHE72_RS08230	COG1164	Oligoendopeptidase f
FHE72_RS08245	COG2346	COG2346, Truncated hemoglobins
FHE72_RS08250	COG0741	lytic transglycosylase activity
FHE72_RS08255	COG4116	CYTH
FHE72_RS08265	COG2357	RelA SpoT domain protein
FHE72_RS08270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FHE72_RS08275	COG0564	pseudouridine synthase activity
FHE72_RS08280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FHE72_RS08285	COG2239	Acts as a magnesium transporter
FHE72_RS08290	COG0569	domain protein
FHE72_RS08290	COG0475	glutathione-regulated potassium exporter activity
FHE72_RS08330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FHE72_RS08340	COG2323	membrane
FHE72_RS08360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FHE72_RS08365	COG2323	membrane
FHE72_RS08370	COG2153	protein acetylation
FHE72_RS08375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FHE72_RS08385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FHE72_RS08415	COG1278	Cold shock
FHE72_RS08425	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS08430	COG0183	Belongs to the thiolase family
FHE72_RS08435	COG1737	Transcriptional regulator
FHE72_RS08440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FHE72_RS08445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHE72_RS08450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHE72_RS08455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHE72_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS08465	COG4221	oxidoreductase activity
FHE72_RS08475	COG1764	response to oxidative stress
FHE72_RS08480	COG1278	Cold shock
FHE72_RS08490	COG1295	ribonuclease BN
FHE72_RS08495	COG3104	oligopeptide transport
FHE72_RS08505	COG1363	Peptidase, m42
FHE72_RS08510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FHE72_RS08520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FHE72_RS08530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FHE72_RS08535	COG3300	MHYT domain
FHE72_RS08535	COG5001	Diguanylate cyclase
FHE72_RS08550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHE72_RS08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHE72_RS08555	COG3320	Male sterility
FHE72_RS08565	COG0861	Integral membrane protein TerC family
FHE72_RS08575	COG1191	sigma factor activity
FHE72_RS08590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHE72_RS08605	COG3594	Acyltransferase
FHE72_RS08610	COG5002	protein histidine kinase activity
FHE72_RS08615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FHE72_RS08620	COG0640	Transcriptional regulator
FHE72_RS08625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FHE72_RS08630	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FHE72_RS08635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FHE72_RS08640	COG0436	Aminotransferase
FHE72_RS08645	COG1850	ribulose-bisphosphate carboxylase activity
FHE72_RS08655	COG0235	Class ii aldolase
FHE72_RS08670	COG1846	Transcriptional regulator
FHE72_RS08675	COG3344	reverse transcriptase
FHE72_RS08685	COG3949	Membrane
FHE72_RS08690	COG4325	translation initiation factor activity
FHE72_RS08695	COG4873	Protein conserved in bacteria
FHE72_RS08705	COG3773	Cell wall hydrolase
FHE72_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS08720	COG0714	Associated with various cellular activities
FHE72_RS08740	COG0390	transport system, permease component
FHE72_RS08750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHE72_RS08755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FHE72_RS08760	COG0436	Aminotransferase
FHE72_RS08765	COG0598	Magnesium transport protein CorA
FHE72_RS08775	COG0720	synthase
FHE72_RS08790	COG0784	Response regulator, receiver
FHE72_RS08790	COG0835	chemotaxis
FHE72_RS08820	COG2200	EAL domain
FHE72_RS08835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FHE72_RS08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS08845	COG4703	Protein of unknown function (DUF1797)
FHE72_RS08850	COG0517	IMP dehydrogenase activity
FHE72_RS08860	COG0583	DNA-binding transcription factor activity
FHE72_RS08870	COG1473	amidohydrolase
FHE72_RS08880	COG1131	(ABC) transporter
FHE72_RS08895	COG0714	Associated with various cellular activities
FHE72_RS08925	COG2304	oxidoreductase activity
FHE72_RS08930	COG0668	transmembrane transport
FHE72_RS08935	COG0450	alkyl hydroperoxide reductase
FHE72_RS08940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS08945	COG1132	(ABC) transporter
FHE72_RS08950	COG1132	(ABC) transporter
FHE72_RS08955	COG1271	oxidase subunit
FHE72_RS08960	COG1294	oxidase, subunit
FHE72_RS08965	COG0569	domain protein
FHE72_RS08970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FHE72_RS08980	COG0561	phosphatase activity
FHE72_RS09000	COG0022	dehydrogenase e1 component
FHE72_RS09015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS09025	COG0726	polysaccharide deacetylase
FHE72_RS09035	COG1982	Orn Lys Arg decarboxylase major
FHE72_RS09045	COG4476	Belongs to the UPF0223 family
FHE72_RS09060	COG0483	inositol monophosphate 1-phosphatase activity
FHE72_RS09085	COG4896	Protein conserved in bacteria
FHE72_RS09100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FHE72_RS09105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FHE72_RS09110	COG2066	Belongs to the glutaminase family
FHE72_RS09115	COG4838	Belongs to the UPF0358 family
FHE72_RS09120	COG0772	Belongs to the SEDS family
FHE72_RS09125	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FHE72_RS09150	COG1845	cytochrome c oxidase, subunit III
FHE72_RS09160	COG3336	cytochrome c oxidase
FHE72_RS09180	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
FHE72_RS09185	COG2340	Cysteine-rich secretory protein family
FHE72_RS09210	COG3679	Belongs to the UPF0342 family
FHE72_RS09235	COG0742	ribosomal rna small subunit methyltransferase
FHE72_RS09240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FHE72_RS09245	COG3314	Sporulation integral membrane protein YlbJ
FHE72_RS09250	COG1752	Esterase of the alpha-beta hydrolase superfamily
FHE72_RS09255	COG3480	Lon protease (S16) C-terminal proteolytic domain
FHE72_RS09260	COG1323	Belongs to the UPF0348 family
FHE72_RS09265	COG1399	metal-binding, possibly nucleic acid-binding protein
FHE72_RS09275	COG1024	Enoyl-CoA hydratase
FHE72_RS09285	COG0454	-acetyltransferase
FHE72_RS09290	COG0439	Biotin carboxylase
FHE72_RS09295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FHE72_RS09300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FHE72_RS09305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FHE72_RS09310	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FHE72_RS09315	COG2001	Belongs to the MraZ family
FHE72_RS09335	COG0768	penicillin binding
FHE72_RS09350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHE72_RS09355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FHE72_RS09360	COG0772	Belongs to the SEDS family
FHE72_RS09365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FHE72_RS09370	COG3879	Bacterial protein of unknown function (DUF881)
FHE72_RS09375	COG3879	Bacterial protein of unknown function (DUF881)
FHE72_RS09380	COG3856	small basic protein
FHE72_RS09385	COG0849	cell division
FHE72_RS09390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FHE72_RS09400	COG1191	sigma factor activity
FHE72_RS09405	COG1191	sigma factor activity
FHE72_RS09410	COG1873	PFAM PRC-barrel domain
FHE72_RS09420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FHE72_RS09425	COG1799	cell septum assembly
FHE72_RS09430	COG0762	integral membrane protein
FHE72_RS09435	COG2302	S4 RNA-binding domain
FHE72_RS09440	COG3599	regulation of cell shape
FHE72_RS09450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FHE72_RS09455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FHE72_RS09460	COG0564	pseudouridine synthase activity
FHE72_RS09465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FHE72_RS09470	COG2233	PERMEase
FHE72_RS09475	COG0540	Belongs to the ATCase OTCase family
FHE72_RS09480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FHE72_RS09520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FHE72_RS09525	COG1561	YicC-like family, N-terminal region
FHE72_RS09530	COG2052	Domain of unknown function (DUF370)
FHE72_RS09535	COG0194	GDP metabolic process
FHE72_RS09545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHE72_RS09550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FHE72_RS09555	COG0242	peptide deformylase activity
FHE72_RS09560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FHE72_RS09565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FHE72_RS09565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FHE72_RS09580	COG1162	GTPase activity
FHE72_RS09585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FHE72_RS09600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FHE72_RS09605	COG1302	Protein conserved in bacteria
FHE72_RS09610	COG1461	Dihydroxyacetone kinase
FHE72_RS09615	COG1760	l-serine dehydratase
FHE72_RS09620	COG1760	l-serine dehydratase
FHE72_RS09625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FHE72_RS09630	COG1349	DNA-binding transcription factor activity
FHE72_RS09635	COG0416	fatty acid biosynthetic process
FHE72_RS09640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FHE72_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS09650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHE72_RS09660	COG1196	nuclear chromosome segregation
FHE72_RS09665	COG0552	protein localization to endoplasmic reticulum
FHE72_RS09670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FHE72_RS09675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FHE72_RS09680	COG0228	four-way junction DNA binding
FHE72_RS09685	COG1837	Belongs to the UPF0109 family
FHE72_RS09695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FHE72_RS09700	COG0336	Belongs to the RNA methyltransferase TrmD family
FHE72_RS09705	COG0335	large ribosomal subunit rRNA binding
FHE72_RS09735	COG2257	FlhB HrpN YscU SpaS Family
FHE72_RS09745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FHE72_RS09750	COG0758	DNA mediated transformation
FHE72_RS09755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FHE72_RS09760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FHE72_RS09765	COG4974	Belongs to the 'phage' integrase family
FHE72_RS09770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FHE72_RS09775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FHE72_RS09785	COG1815	bacterial-type flagellum-dependent cell motility
FHE72_RS09790	COG1558	bacterial-type flagellum-dependent cell motility
FHE72_RS09795	COG1677	Flagellar hook-basal body complex protein FliE
FHE72_RS09800	COG1766	The M ring may be actively involved in energy transduction
FHE72_RS09805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FHE72_RS09810	COG1317	bacterial-type flagellum organization
FHE72_RS09815	COG1157	protein secretion by the type III secretion system
FHE72_RS09820	COG2882	bacterial-type flagellum organization
FHE72_RS09835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FHE72_RS09850	COG1582	Flagellar protein (FlbD)
FHE72_RS09855	COG1580	Controls the rotational direction of flagella during chemotaxis
FHE72_RS09860	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FHE72_RS09865	COG1776	CheC inhibitor of MCP methylation
FHE72_RS09865	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FHE72_RS09870	COG2201	protein-glutamate methylesterase activity
FHE72_RS09875	COG3190	flagellar
FHE72_RS09880	COG1338	Plays a role in the flagellum-specific transport system
FHE72_RS09885	COG1987	bacterial-type flagellum assembly
FHE72_RS09895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FHE72_RS09905	COG1419	protein localization to endoplasmic reticulum
FHE72_RS09910	COG0455	bacterial-type flagellum organization
FHE72_RS09915	COG2201	protein-glutamate methylesterase activity
FHE72_RS09920	COG2198	Histidine kinase
FHE72_RS09920	COG0643	Histidine kinase
FHE72_RS09925	COG0835	chemotaxis
FHE72_RS09930	COG1776	CheC inhibitor of MCP methylation
FHE72_RS09935	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FHE72_RS09940	COG1191	sigma factor activity
FHE72_RS09950	COG0052	Belongs to the universal ribosomal protein uS2 family
FHE72_RS09955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FHE72_RS09960	COG0528	UMP kinase activity
FHE72_RS09970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FHE72_RS09975	COG4589	Belongs to the CDS family
FHE72_RS09985	COG0750	zinc metalloprotease
FHE72_RS09990	COG0442	prolyl-tRNA aminoacylation
FHE72_RS09995	COG2176	DNA-directed DNA polymerase activity
FHE72_RS10000	COG0779	Required for maturation of 30S ribosomal subunits
FHE72_RS10005	COG0195	Participates in both transcription termination and antitermination
FHE72_RS10010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FHE72_RS10015	COG1358	cellular component organization or biogenesis
FHE72_RS10025	COG1550	Protein conserved in bacteria
FHE72_RS10030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FHE72_RS10040	COG0196	riboflavin kinase activity
FHE72_RS10045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FHE72_RS10050	COG1185	polyribonucleotide nucleotidyltransferase activity
FHE72_RS10055	COG0726	polysaccharide deacetylase
FHE72_RS10065	COG1873	PFAM PRC-barrel domain
FHE72_RS10070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FHE72_RS10075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHE72_RS10080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FHE72_RS10085	COG0527	aspartate kinase activity
FHE72_RS10110	COG1674	ftsk spoiiie
FHE72_RS10110	COG4980	gas vesicle protein
FHE72_RS10115	COG2188	Transcriptional regulator
FHE72_RS10145	COG0612	Peptidase, M16
FHE72_RS10150	COG0300	oxidoreductase activity
FHE72_RS10165	COG1426	Protein conserved in bacteria
FHE72_RS10170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FHE72_RS10175	COG1058	Belongs to the CinA family
FHE72_RS10175	COG1546	Belongs to the CinA family
FHE72_RS10180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FHE72_RS10190	COG1692	metallophosphoesterase
FHE72_RS10195	COG2359	stage V sporulation protein S
FHE72_RS10205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FHE72_RS10205	COG0674	pyruvate-flavodoxin oxidoreductase activity
FHE72_RS10210	COG1013	pyruvate-flavodoxin oxidoreductase activity
FHE72_RS10240	COG1216	Glycosyl transferase, family 2
FHE72_RS10275	COG1086	Polysaccharide biosynthesis protein
FHE72_RS10300	COG0529	Catalyzes the synthesis of activated sulfate
FHE72_RS10305	COG3273	potassium ion transport
FHE72_RS10305	COG0471	metal ion transport
FHE72_RS10310	COG2046	Belongs to the sulfate adenylyltransferase family
FHE72_RS10325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FHE72_RS10330	COG4550	Control of competence regulator ComK, YlbF/YmcA
FHE72_RS10345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FHE72_RS10345	COG0551	DNA topoisomerase type I activity
FHE72_RS10355	COG1966	Carbon starvation protein
FHE72_RS10365	COG0493	'glutamate synthase
FHE72_RS10395	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS10400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FHE72_RS10405	COG2720	vancomycin resistance protein
FHE72_RS10420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FHE72_RS10425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FHE72_RS10445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FHE72_RS10455	COG0464	growth
FHE72_RS10460	COG2860	membrane
FHE72_RS10470	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FHE72_RS10475	COG0789	Transcriptional regulator
FHE72_RS10480	COG0174	glutamine synthetase
FHE72_RS10485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHE72_RS10490	COG1388	LysM domain
FHE72_RS10495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FHE72_RS10500	COG4224	UPF0291 protein
FHE72_RS10515	COG3763	UPF0154 protein
FHE72_RS10520	COG4851	CamS sex pheromone cAM373 precursor
FHE72_RS10525	COG1132	(ABC) transporter
FHE72_RS10530	COG1132	(ABC) transporter
FHE72_RS10540	COG0785	Cytochrome C biogenesis protein
FHE72_RS10545	COG2201	protein-glutamate methylesterase activity
FHE72_RS10550	COG4846	Membrane protein involved in cytochrome C biogenesis
FHE72_RS10555	COG1994	Peptidase M50
FHE72_RS10570	COG3852	Histidine kinase
FHE72_RS10595	COG0419	ATPase involved in DNA repair
FHE72_RS10600	COG0419	ATPase involved in DNA repair
FHE72_RS10625	COG1999	signal sequence binding
FHE72_RS10630	COG1247	-acetyltransferase
FHE72_RS10665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FHE72_RS10690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FHE72_RS10690	COG0646	methionine synthase
FHE72_RS10695	COG1410	methionine synthase
FHE72_RS10695	COG0646	methionine synthase
FHE72_RS10705	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS10710	COG0346	lactoylglutathione lyase activity
FHE72_RS10715	COG0400	carboxylic ester hydrolase activity
FHE72_RS10725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FHE72_RS10725	COG2169	Transcriptional regulator
FHE72_RS10750	COG0584	glycerophosphoryl diester phosphodiesterase
FHE72_RS10760	COG2267	carboxylic ester hydrolase activity
FHE72_RS10780	COG1368	sulfuric ester hydrolase activity
FHE72_RS10790	COG2205	protein histidine kinase activity
FHE72_RS10795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS10800	COG1968	undecaprenyl-diphosphatase activity
FHE72_RS10805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FHE72_RS10825	COG1183	phosphatidylcholine synthase activity
FHE72_RS10835	COG1695	Transcriptional regulator
FHE72_RS10860	COG2226	methyltransferase
FHE72_RS10865	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS10870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHE72_RS10875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS10885	COG5566	PFAM Mor transcription activator
FHE72_RS10895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FHE72_RS10905	COG2814	Major facilitator Superfamily
FHE72_RS10935	COG1846	Transcriptional regulator
FHE72_RS10940	COG0778	Nitroreductase
FHE72_RS10950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FHE72_RS10960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FHE72_RS10985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHE72_RS10990	COG2239	Acts as a magnesium transporter
FHE72_RS10995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FHE72_RS11030	COG0477	Major facilitator Superfamily
FHE72_RS11035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHE72_RS11040	COG1309	transcriptional regulator
FHE72_RS11050	COG0463	Glycosyl transferase, family 2
FHE72_RS11050	COG1216	Glycosyl transferase, family 2
FHE72_RS11055	COG1309	transcriptional regulator
FHE72_RS11060	COG2814	Major facilitator Superfamily
FHE72_RS11065	COG4336	lyase activity
FHE72_RS11075	COG0662	Cupin 2, conserved barrel domain protein
FHE72_RS11090	COG4807	Protein conserved in bacteria
FHE72_RS11120	COG2323	membrane
FHE72_RS11130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FHE72_RS11160	COG3279	Response regulator of the LytR AlgR family
FHE72_RS11170	COG1668	transmembrane transport
FHE72_RS11205	COG0346	lactoylglutathione lyase activity
FHE72_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS11220	COG1301	dicarboxylic acid transport
FHE72_RS11230	COG0583	DNA-binding transcription factor activity
FHE72_RS11235	COG0730	response to heat
FHE72_RS11245	COG0110	maltose O-acetyltransferase activity
FHE72_RS11265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FHE72_RS11275	COG1231	oxidoreductase activity
FHE72_RS11280	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS11305	COG0300	oxidoreductase activity
FHE72_RS11320	COG1597	lipid kinase activity
FHE72_RS11325	COG0322	excinuclease ABC activity
FHE72_RS11355	COG0372	Belongs to the citrate synthase family
FHE72_RS11385	COG1131	(ABC) transporter
FHE72_RS11390	COG1511	domain protein
FHE72_RS11390	COG0842	Transport permease protein
FHE72_RS11410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FHE72_RS11425	COG1051	belongs to the nudix hydrolase family
FHE72_RS11450	COG2112	serine threonine protein kinase
FHE72_RS11455	COG2070	2-Nitropropane dioxygenase
FHE72_RS11495	COG2362	D-Aminopeptidase
FHE72_RS11500	COG0601	transmembrane transport
FHE72_RS11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHE72_RS11515	COG4166	transmembrane transport
FHE72_RS11520	COG1619	proteins homologs of microcin C7 resistance protein MccF
FHE72_RS11530	COG0791	NLP P60 protein
FHE72_RS11535	COG4608	Belongs to the ABC transporter superfamily
FHE72_RS11550	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS11575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FHE72_RS11600	COG2124	cytochrome p450
FHE72_RS11610	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS11615	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS11625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FHE72_RS11630	COG0596	Alpha beta hydrolase
FHE72_RS11635	COG0456	acetyltransferase
FHE72_RS11665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FHE72_RS11675	COG2340	Cysteine-rich secretory protein family
FHE72_RS11695	COG4326	sporulation control protein
FHE72_RS11745	COG1309	transcriptional regulator
FHE72_RS11750	COG0789	Transcriptional regulator
FHE72_RS11755	COG1253	flavin adenine dinucleotide binding
FHE72_RS11760	COG2217	Heavy metal translocating P-type atpase
FHE72_RS11775	COG1619	proteins homologs of microcin C7 resistance protein MccF
FHE72_RS11785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHE72_RS11810	COG2309	aminopeptidase activity
FHE72_RS11815	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FHE72_RS11820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FHE72_RS11830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FHE72_RS11845	COG0006	proline dipeptidase activity
FHE72_RS11865	COG1380	Effector of murein hydrolase LrgA
FHE72_RS11870	COG1346	cytolysis
FHE72_RS11875	COG0024	Methionine aminopeptidase
FHE72_RS11880	COG0840	transmembrane signaling receptor activity
FHE72_RS11885	COG3584	3D domain protein
FHE72_RS11885	COG1388	LysM domain
FHE72_RS11890	COG3584	3D domain protein
FHE72_RS11890	COG1388	LysM domain
FHE72_RS11895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FHE72_RS11950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FHE72_RS11955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS11975	COG0824	Thioesterase
FHE72_RS11985	COG4841	protein insertion into membrane
FHE72_RS11995	COG2843	Capsule synthesis protein
FHE72_RS12000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FHE72_RS12005	COG2233	PERMEase
FHE72_RS12010	COG0517	IMP dehydrogenase activity
FHE72_RS12010	COG1125	glycine betaine transport
FHE72_RS12015	COG1174	glycine betaine transport
FHE72_RS12020	COG1732	Glycine betaine
FHE72_RS12025	COG1832	CoA-binding protein
FHE72_RS12030	COG0187	DNA topoisomerase II activity
FHE72_RS12035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FHE72_RS12040	COG1115	amino acid carrier protein
FHE72_RS12110	COG2233	PERMEase
FHE72_RS12125	COG1648	precorrin-2 dehydrogenase activity
FHE72_RS12130	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
FHE72_RS12145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FHE72_RS12150	COG0529	Catalyzes the synthesis of activated sulfate
FHE72_RS12160	COG0306	phosphate transporter
FHE72_RS12190	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS12200	COG1024	Enoyl-CoA hydratase
FHE72_RS12215	COG1309	transcriptional regulator
FHE72_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS12240	COG1823	symporter activity
FHE72_RS12245	COG0352	thiamine-phosphate diphosphorylase activity
FHE72_RS12250	COG0351	phosphomethylpyrimidine kinase
FHE72_RS12255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FHE72_RS12260	COG2022	thiamine diphosphate biosynthetic process
FHE72_RS12270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FHE72_RS12275	COG0352	thiamine-phosphate diphosphorylase activity
FHE72_RS12280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FHE72_RS12285	COG4172	Belongs to the ABC transporter superfamily
FHE72_RS12295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FHE72_RS12300	COG2197	response regulator
FHE72_RS12305	COG4585	Histidine kinase
FHE72_RS12350	COG0708	Exodeoxyribonuclease III
FHE72_RS12360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS12375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FHE72_RS12380	COG2340	Cysteine-rich secretory protein family
FHE72_RS12385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FHE72_RS12420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FHE72_RS12430	COG0693	protein deglycase activity
FHE72_RS12435	COG2084	Dehydrogenase
FHE72_RS12450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS12450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS12460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS12470	COG0745	RESPONSE REGULATOR receiver
FHE72_RS12475	COG5002	protein histidine kinase activity
FHE72_RS12480	COG4086	secreted protein
FHE72_RS12485	COG0730	response to heat
FHE72_RS12490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS12490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS12495	COG0425	Belongs to the sulfur carrier protein TusA family
FHE72_RS12495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS12500	COG2210	Belongs to the sulfur carrier protein TusA family
FHE72_RS12505	COG0425	Belongs to the sulfur carrier protein TusA family
FHE72_RS12510	COG1937	Protein conserved in bacteria
FHE72_RS12520	COG0003	Pfam Anion-transporting ATPase
FHE72_RS12530	COG1966	Carbon starvation protein
FHE72_RS12555	COG2309	aminopeptidase activity
FHE72_RS12565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FHE72_RS12570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FHE72_RS12575	COG2409	Drug exporters of the RND superfamily
FHE72_RS12580	COG0517	IMP dehydrogenase activity
FHE72_RS12580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FHE72_RS12585	COG2176	DNA-directed DNA polymerase activity
FHE72_RS12590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FHE72_RS12595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FHE72_RS12610	COG2096	Adenosyltransferase
FHE72_RS12625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FHE72_RS12630	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
FHE72_RS12635	COG1120	ATPase activity
FHE72_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHE72_RS12645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FHE72_RS12650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS12670	COG2814	Major facilitator Superfamily
FHE72_RS12675	COG2996	Protein conserved in bacteria
FHE72_RS12680	COG2252	PERMEase
FHE72_RS12685	COG2223	nitrite transmembrane transporter activity
FHE72_RS12715	COG0488	(ABC) transporter
FHE72_RS12720	COG0514	ATP-dependent DNA helicase (RecQ)
FHE72_RS12770	COG0706	membrane insertase activity
FHE72_RS12775	COG1686	Belongs to the peptidase S11 family
FHE72_RS12780	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
FHE72_RS12785	COG3853	Toxic anion resistance protein (TelA)
FHE72_RS12790	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS12800	COG4548	von Willebrand factor, type A
FHE72_RS12805	COG0714	Associated with various cellular activities
FHE72_RS12830	COG2105	PFAM AIG2 family protein
FHE72_RS12830	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FHE72_RS12835	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS12850	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHE72_RS12855	COG0567	Dehydrogenase, E1 component
FHE72_RS12870	COG5002	protein histidine kinase activity
FHE72_RS12875	COG0745	RESPONSE REGULATOR receiver
FHE72_RS12885	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FHE72_RS12900	COG0432	Pfam Uncharacterised protein family UPF0047
FHE72_RS12905	COG3011	Protein conserved in bacteria
FHE72_RS12910	COG1366	Belongs to the anti-sigma-factor antagonist family
FHE72_RS12950	COG1309	transcriptional regulator
FHE72_RS12960	COG2076	Multidrug Resistance protein
FHE72_RS12975	COG0697	spore germination
FHE72_RS12980	COG0628	permease
FHE72_RS12995	COG3340	Belongs to the peptidase S51 family
FHE72_RS13000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FHE72_RS13010	COG2814	Major facilitator Superfamily
FHE72_RS13015	COG1278	Cold shock
FHE72_RS13025	COG1970	mechanosensitive ion channel activity
FHE72_RS13040	COG0494	nUDIX hydrolase
FHE72_RS13075	COG2226	methyltransferase
FHE72_RS13095	COG0134	indole-3-glycerol-phosphate synthase activity
FHE72_RS13105	COG0512	Glutamine amidotransferase of anthranilate synthase
FHE72_RS13105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FHE72_RS13120	COG1233	COG1233 Phytoene dehydrogenase and related
FHE72_RS13125	COG4145	pantothenate transmembrane transporter activity
FHE72_RS13140	COG0671	phosphoesterase, PA-phosphatase related
FHE72_RS13145	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FHE72_RS13150	COG1793	dna ligase
FHE72_RS13150	COG3285	dna ligase
FHE72_RS13155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FHE72_RS13160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FHE72_RS13175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FHE72_RS13175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FHE72_RS13180	COG0307	riboflavin synthase, alpha
FHE72_RS13185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FHE72_RS13185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FHE72_RS13195	COG4667	esterase of the alpha-beta hydrolase superfamily
FHE72_RS13210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FHE72_RS13215	COG1131	(ABC) transporter
FHE72_RS13240	COG0586	Pfam SNARE associated Golgi protein
FHE72_RS13265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FHE72_RS13275	COG1215	transferase activity, transferring glycosyl groups
FHE72_RS13290	COG0534	Mate efflux family protein
FHE72_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS13300	COG2340	Cysteine-rich secretory protein family
FHE72_RS13320	COG0477	Major facilitator Superfamily
FHE72_RS13325	COG1846	Transcriptional regulator
FHE72_RS13335	COG0523	cobalamin synthesis protein
FHE72_RS13345	COG1316	TRANSCRIPTIONal
FHE72_RS13350	COG0793	Belongs to the peptidase S41A family
FHE72_RS13350	COG3409	Peptidoglycan-binding domain 1 protein
FHE72_RS13360	COG1876	peptidase activity
FHE72_RS13375	COG4326	sporulation control protein
FHE72_RS13380	COG0515	serine threonine protein kinase
FHE72_RS13405	COG4479	Belongs to the UPF0346 family
FHE72_RS13415	COG1509	lysine 2,3-aminomutase activity
FHE72_RS13425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHE72_RS13430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FHE72_RS13435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FHE72_RS13445	COG0840	transmembrane signaling receptor activity
FHE72_RS13455	COG2190	(PTS) system
FHE72_RS13460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS13465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS13485	COG2755	lipolytic protein G-D-S-L family
FHE72_RS13500	COG1307	EDD domain protein, DegV family
FHE72_RS13510	COG2135	peptidase activity
FHE72_RS13515	COG1272	protein, Hemolysin III
FHE72_RS13520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHE72_RS13525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FHE72_RS13540	COG2521	methyltransferase
FHE72_RS13540	COG2136	Putative SAM-dependent methyltransferase
FHE72_RS13555	COG0488	(ABC) transporter
FHE72_RS13560	COG1418	mRNA catabolic process
FHE72_RS13565	COG1307	EDD domain protein, DegV family
FHE72_RS13595	COG1321	iron dependent repressor
FHE72_RS13600	COG1278	Cold shock
FHE72_RS13610	COG0328	RNA-DNA hybrid ribonuclease activity
FHE72_RS13615	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FHE72_RS13620	COG0328	RNA-DNA hybrid ribonuclease activity
FHE72_RS13640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHE72_RS13655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FHE72_RS13660	COG1755	Isoprenylcysteine carboxyl methyltransferase
FHE72_RS13665	COG3424	synthase
FHE72_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS13680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FHE72_RS13685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FHE72_RS13695	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FHE72_RS13700	COG1199	ATP-dependent helicase activity
FHE72_RS13710	COG0116	Belongs to the methyltransferase superfamily
FHE72_RS13725	COG4474	Belongs to the UPF0398 family
FHE72_RS13735	COG3359	exonuclease
FHE72_RS13740	COG1205	dead DEAH box helicase
FHE72_RS13740	COG1111	helicase
FHE72_RS13745	COG0071	Belongs to the small heat shock protein (HSP20) family
FHE72_RS13780	COG4499	WXG100 protein secretion system (Wss), protein YukC
FHE72_RS13780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHE72_RS13790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FHE72_RS13795	COG3935	DnaD domain protein
FHE72_RS13800	COG0017	Asparaginyl-tRNA synthetase
FHE72_RS13805	COG0436	Aminotransferase
FHE72_RS13830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FHE72_RS13835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FHE72_RS13855	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS13860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FHE72_RS13875	COG1694	Mazg nucleotide pyrophosphohydrolase
FHE72_RS13880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS13885	COG2738	Putative neutral zinc metallopeptidase
FHE72_RS13895	COG4347	Protein of unknown function (DUF1405)
FHE72_RS13905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FHE72_RS13920	COG5582	Belongs to the UPF0302 family
FHE72_RS13925	COG0457	Tetratricopeptide repeat
FHE72_RS13935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FHE72_RS13940	COG0287	Prephenate dehydrogenase
FHE72_RS13945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FHE72_RS13950	COG4401	Chorismate mutase type I
FHE72_RS13960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FHE72_RS13965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FHE72_RS13970	COG0105	UTP biosynthetic process
FHE72_RS13975	COG0142	geranyltranstransferase activity
FHE72_RS13980	COG2226	methyltransferase
FHE72_RS13985	COG0142	geranyltranstransferase activity
FHE72_RS13995	COG0302	gtp cyclohydrolase
FHE72_RS14000	COG0776	regulation of translation
FHE72_RS14005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FHE72_RS14025	COG1160	GTP binding
FHE72_RS14055	COG1304	FMN binding
FHE72_RS14060	COG0539	negative regulation of cytoplasmic translation
FHE72_RS14065	COG0204	Acyl-transferase
FHE72_RS14070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FHE72_RS14085	COG2959	enzyme of heme biosynthesis
FHE72_RS14090	COG3773	Cell wall hydrolase
FHE72_RS14090	COG3409	Peptidoglycan-binding domain 1 protein
FHE72_RS14100	COG2339	peptidase activity
FHE72_RS14110	COG0492	ferredoxin-NADP+ reductase activity
FHE72_RS14115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHE72_RS14125	COG0789	Transcriptional regulator
FHE72_RS14130	COG1408	metallophosphoesterase
FHE72_RS14175	COG0514	ATP-dependent DNA helicase (RecQ)
FHE72_RS14180	COG4955	Helix-turn-helix domain
FHE72_RS14185	COG1141	Ferredoxin
FHE72_RS14190	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FHE72_RS14205	COG1595	DNA-templated transcription, initiation
FHE72_RS14210	COG5002	protein histidine kinase activity
FHE72_RS14215	COG0745	RESPONSE REGULATOR receiver
FHE72_RS14225	COG1333	cytochrome c biogenesis protein
FHE72_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS14240	COG0700	Nucleoside recognition
FHE72_RS14245	COG2715	membrane protein required for spore maturation
FHE72_RS14250	COG1686	Belongs to the peptidase S11 family
FHE72_RS14255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FHE72_RS14265	COG1547	Domain of unknown function (DUF309)
FHE72_RS14280	COG0697	spore germination
FHE72_RS14305	COG2172	sigma factor antagonist activity
FHE72_RS14315	COG1686	Belongs to the peptidase S11 family
FHE72_RS14330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FHE72_RS14335	COG4974	Belongs to the 'phage' integrase family
FHE72_RS14345	COG0735	belongs to the Fur family
FHE72_RS14350	COG1300	Membrane
FHE72_RS14370	COG0667	Aldo Keto reductase
FHE72_RS14385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FHE72_RS14390	COG0183	Belongs to the thiolase family
FHE72_RS14395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FHE72_RS14400	COG1073	alpha beta
FHE72_RS14410	COG4918	Iron-sulphur cluster biosynthesis
FHE72_RS14435	COG4975	Glucose uptake
FHE72_RS14445	COG0300	oxidoreductase activity
FHE72_RS14450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS14455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FHE72_RS14460	COG0463	Glycosyl transferase, family 2
FHE72_RS14465	COG1902	pentaerythritol trinitrate reductase activity
FHE72_RS14480	COG1234	tRNA 3'-trailer cleavage
FHE72_RS14485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FHE72_RS14510	COG0835	chemotaxis
FHE72_RS14515	COG2195	Cleaves the N-terminal amino acid of tripeptides
FHE72_RS14525	COG0346	lactoylglutathione lyase activity
FHE72_RS14535	COG1376	ErfK ybiS ycfS ynhG family protein
FHE72_RS14540	COG4129	membrane
FHE72_RS14545	COG1126	abc transporter atp-binding protein
FHE72_RS14550	COG0765	amino acid transport
FHE72_RS14555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHE72_RS14565	COG1703	isobutyryl-CoA mutase activity
FHE72_RS14570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FHE72_RS14570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FHE72_RS14575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FHE72_RS14580	COG4412	M6 family metalloprotease domain protein
FHE72_RS14580	COG1404	Belongs to the peptidase S8 family
FHE72_RS14585	COG0508	dehydrogenase complex catalyzes the overall conversion of
FHE72_RS14590	COG0022	dehydrogenase e1 component
FHE72_RS14595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FHE72_RS14600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHE72_RS14615	COG0280	phosphate acetyltransferase
FHE72_RS14620	COG3829	transcription factor binding
FHE72_RS14620	COG3290	protein histidine kinase activity
FHE72_RS14630	COG0584	glycerophosphoryl diester phosphodiesterase
FHE72_RS14640	COG0745	RESPONSE REGULATOR receiver
FHE72_RS14645	COG0750	zinc metalloprotease
FHE72_RS14650	COG0497	DNA recombination
FHE72_RS14660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FHE72_RS14665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FHE72_RS14680	COG1722	exodeoxyribonuclease VII activity
FHE72_RS14685	COG1570	exodeoxyribonuclease VII activity
FHE72_RS14690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FHE72_RS14700	COG1302	Protein conserved in bacteria
FHE72_RS14705	COG0439	Biotin carboxylase
FHE72_RS14710	COG0511	ligase activity, forming carbon-carbon bonds
FHE72_RS14750	COG3854	ATPases associated with a variety of cellular activities
FHE72_RS14755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FHE72_RS14760	COG0006	proline dipeptidase activity
FHE72_RS14785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHE72_RS14790	COG0095	Lipoate-protein ligase
FHE72_RS14795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS14800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FHE72_RS14810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FHE72_RS14815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHE72_RS14830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FHE72_RS14850	COG4537	Required for transformation and DNA binding
FHE72_RS14860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FHE72_RS14875	COG1393	Belongs to the ArsC family
FHE72_RS14885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS14895	COG1733	regulation of RNA biosynthetic process
FHE72_RS14900	COG0011	TIGRFAM Protein of
FHE72_RS14915	COG1368	sulfuric ester hydrolase activity
FHE72_RS14920	COG1940	carbohydrate kinase activity
FHE72_RS14925	COG4483	Protein conserved in bacteria
FHE72_RS14930	COG0697	spore germination
FHE72_RS14940	COG0457	Tetratricopeptide repeat
FHE72_RS14940	COG0705	Rhomboid family
FHE72_RS14955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FHE72_RS14960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FHE72_RS14970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FHE72_RS14990	COG0840	transmembrane signaling receptor activity
FHE72_RS14995	COG0704	Plays a role in the regulation of phosphate uptake
FHE72_RS15000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHE72_RS15005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHE72_RS15010	COG0581	inorganic phosphate transmembrane transporter activity
FHE72_RS15015	COG0573	inorganic phosphate transmembrane transporter activity
FHE72_RS15020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FHE72_RS15030	COG0477	Major facilitator Superfamily
FHE72_RS15040	COG2839	Protein conserved in bacteria
FHE72_RS15045	COG1283	sodium-dependent phosphate transmembrane transporter activity
FHE72_RS15050	COG5521	maltodextrose utilization protein MalA
FHE72_RS15055	COG2814	Major facilitator Superfamily
FHE72_RS15060	COG2814	Major facilitator Superfamily
FHE72_RS15070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FHE72_RS15075	COG4709	membrane
FHE72_RS15080	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
FHE72_RS15090	COG0735	belongs to the Fur family
FHE72_RS15095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FHE72_RS15100	COG1121	(ABC) transporter
FHE72_RS15105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS15115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FHE72_RS15120	COG0513	Belongs to the DEAD box helicase family
FHE72_RS15130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FHE72_RS15135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FHE72_RS15140	COG2384	SAM-dependent methyltransferase
FHE72_RS15145	COG2010	Cytochrome c
FHE72_RS15160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FHE72_RS15165	COG0358	DNA primase activity
FHE72_RS15170	COG1671	Belongs to the UPF0178 family
FHE72_RS15185	COG0517	IMP dehydrogenase activity
FHE72_RS15190	COG0423	glycine-tRNA ligase activity
FHE72_RS15195	COG1381	Involved in DNA repair and RecF pathway recombination
FHE72_RS15210	COG0295	cytidine deaminase activity
FHE72_RS15215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FHE72_RS15225	COG1480	7TM receptor with intracellular HD hydrolase
FHE72_RS15230	COG1702	phosphate starvation-inducible protein PhoH
FHE72_RS15285	COG4864	UPF0365 protein
FHE72_RS15290	COG1030	water channel activity
FHE72_RS15295	COG1610	YqeY-like protein
FHE72_RS15300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FHE72_RS15305	COG1283	sodium-dependent phosphate transmembrane transporter activity
FHE72_RS15310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FHE72_RS15315	COG0366	Alpha amylase catalytic
FHE72_RS15320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FHE72_RS15325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FHE72_RS15335	COG0484	heat shock protein binding
FHE72_RS15340	COG0443	Heat shock 70 kDa protein
FHE72_RS15345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FHE72_RS15355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FHE72_RS15360	COG0481	GTPase activity
FHE72_RS15370	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS15380	COG0268	Binds directly to 16S ribosomal RNA
FHE72_RS15385	COG1466	dna polymerase III delta subunit
FHE72_RS15395	COG2333	competence protein COMEC
FHE72_RS15395	COG0658	competence protein
FHE72_RS15400	COG2131	deaminase
FHE72_RS15405	COG1596	polysaccharide export
FHE72_RS15405	COG1555	photosystem II stabilization
FHE72_RS15410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FHE72_RS15415	COG2226	methyltransferase
FHE72_RS15420	COG0799	negative regulation of ribosome biogenesis
FHE72_RS15425	COG1713	HD superfamily hydrolase involved in NAD metabolism
FHE72_RS15430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FHE72_RS15435	COG1534	Rna-binding protein
FHE72_RS15445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FHE72_RS15450	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FHE72_RS15460	COG1183	phosphatidylcholine synthase activity
FHE72_RS15470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FHE72_RS15530	COG0626	cystathionine gamma-synthase activity
FHE72_RS15535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHE72_RS15540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FHE72_RS15545	COG2226	methyltransferase
FHE72_RS15565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHE72_RS15570	COG0572	uridine kinase
FHE72_RS15590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FHE72_RS15595	COG3906	Belongs to the UPF0473 family
FHE72_RS15600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FHE72_RS15605	COG4472	Bacterial protein of unknown function (DUF965)
FHE72_RS15630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FHE72_RS15635	COG1268	BioY protein
FHE72_RS15640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FHE72_RS15655	COG1104	cysteine desulfurase activity
FHE72_RS15660	COG1959	2 iron, 2 sulfur cluster binding
FHE72_RS15665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FHE72_RS15675	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FHE72_RS15680	COG1131	(ABC) transporter
FHE72_RS15685	COG1131	(ABC) transporter
FHE72_RS15690	COG1725	Transcriptional regulator
FHE72_RS15700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FHE72_RS15710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FHE72_RS15715	COG0124	histidyl-tRNA synthetase
FHE72_RS15725	COG4991	sh3 domain protein
FHE72_RS15725	COG3103	Sh3 type 3 domain protein
FHE72_RS15725	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS15730	COG1490	D-aminoacyl-tRNA deacylase activity
FHE72_RS15735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHE72_RS15740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHE72_RS15745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FHE72_RS15745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FHE72_RS15755	COG5416	Lipopolysaccharide assembly protein A domain
FHE72_RS15760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FHE72_RS15765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FHE72_RS15765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FHE72_RS15775	COG2244	polysaccharide biosynthetic process
FHE72_RS15780	COG2323	membrane
FHE72_RS15785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FHE72_RS15795	COG1862	Preprotein translocase
FHE72_RS15805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FHE72_RS15840	COG1388	LysM domain
FHE72_RS15845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FHE72_RS15850	COG0157	Belongs to the NadC ModD family
FHE72_RS15855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FHE72_RS15860	COG1104	cysteine desulfurase activity
FHE72_RS15865	COG1104	cysteine desulfurase activity
FHE72_RS15870	COG1827	regulation of RNA biosynthetic process
FHE72_RS15875	COG0077	Prephenate dehydratase
FHE72_RS15880	COG4492	Belongs to the UPF0735 family
FHE72_RS15885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FHE72_RS15890	COG3290	protein histidine kinase activity
FHE72_RS15895	COG3344	reverse transcriptase
FHE72_RS15900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FHE72_RS15905	COG2868	ribosomal protein
FHE72_RS15910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FHE72_RS15915	COG1530	ribonuclease E activity
FHE72_RS15925	COG0739	heme binding
FHE72_RS15930	COG2894	cell division
FHE72_RS15940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FHE72_RS15945	COG1792	Involved in formation and maintenance of cell shape
FHE72_RS15955	COG2003	Belongs to the UPF0758 family
FHE72_RS15990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FHE72_RS16050	COG3706	GGDEF domain
FHE72_RS16055	COG0285	dihydrofolate synthase activity
FHE72_RS16060	COG0525	valine-tRNA ligase activity
FHE72_RS16070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FHE72_RS16075	COG1388	LysM domain
FHE72_RS16075	COG1388	LysM domain
FHE72_RS16080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FHE72_RS16085	COG0113	porphobilinogen synthase activity
FHE72_RS16100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FHE72_RS16115	COG1126	abc transporter atp-binding protein
FHE72_RS16120	COG0765	amino acid transport
FHE72_RS16130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FHE72_RS16135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FHE72_RS16140	COG1067	ATP-dependent peptidase activity
FHE72_RS16140	COG0470	DNA polymerase III
FHE72_RS16160	COG0544	peptidyl-prolyl cis-trans isomerase activity
FHE72_RS16165	COG0457	Tetratricopeptide repeat
FHE72_RS16165	COG1477	protein flavinylation
FHE72_RS16180	COG0622	Phosphoesterase
FHE72_RS16185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FHE72_RS16195	COG5401	PFAM Sporulation and spore germination
FHE72_RS16205	COG1846	Transcriptional regulator
FHE72_RS16210	COG2197	response regulator
FHE72_RS16215	COG0824	Thioesterase
FHE72_RS16220	COG0737	Belongs to the 5'-nucleotidase family
FHE72_RS16225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FHE72_RS16230	COG1053	succinate dehydrogenase
FHE72_RS16235	COG2009	succinate dehydrogenase
FHE72_RS16240	COG1719	4-vinyl reductase, 4VR
FHE72_RS16250	COG0322	excinuclease ABC activity
FHE72_RS16275	COG1215	transferase activity, transferring glycosyl groups
FHE72_RS16300	COG3118	belongs to the thioredoxin family
FHE72_RS16305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FHE72_RS16310	COG2086	electron transfer activity
FHE72_RS16315	COG1024	Enoyl-CoA hydratase
FHE72_RS16320	COG1309	transcriptional regulator
FHE72_RS16325	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS16330	COG3766	membrane
FHE72_RS16335	COG1193	negative regulation of DNA recombination
FHE72_RS16340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FHE72_RS16340	COG1796	DNA polymerase
FHE72_RS16345	COG1286	toxin biosynthetic process
FHE72_RS16350	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FHE72_RS16360	COG0072	phenylalanine-tRNA ligase activity
FHE72_RS16360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHE72_RS16365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FHE72_RS16370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHE72_RS16380	COG1335	isochorismatase
FHE72_RS16385	COG1363	Peptidase, m42
FHE72_RS16400	COG0398	Pfam SNARE associated Golgi protein
FHE72_RS16410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FHE72_RS16420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FHE72_RS16425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FHE72_RS16445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FHE72_RS16460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FHE72_RS16465	COG0237	dephospho-CoA kinase activity
FHE72_RS16470	COG1971	Probably functions as a manganese efflux pump
FHE72_RS16475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHE72_RS16480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHE72_RS16480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHE72_RS16485	COG0330	HflC and HflK could
FHE72_RS16490	COG0330	HflC and HflK could
FHE72_RS16495	COG5002	protein histidine kinase activity
FHE72_RS16500	COG0745	RESPONSE REGULATOR receiver
FHE72_RS16510	COG0039	L-malate dehydrogenase activity
FHE72_RS16515	COG0538	isocitrate dehydrogenase activity
FHE72_RS16520	COG0372	Belongs to the citrate synthase family
FHE72_RS16525	COG2707	UPF0756 membrane protein
FHE72_RS16530	COG0628	permease
FHE72_RS16535	COG3030	protein affecting phage T7 exclusion by the F plasmid
FHE72_RS16545	COG0205	6-phosphofructokinase activity
FHE72_RS16550	COG0825	malonyl-CoA metabolic process
FHE72_RS16555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FHE72_RS16560	COG2186	Transcriptional regulator
FHE72_RS16565	COG0281	malic enzyme
FHE72_RS16570	COG0587	DNA-directed DNA polymerase activity
FHE72_RS16635	COG2814	Major facilitator Superfamily
FHE72_RS16645	COG0456	acetyltransferase
FHE72_RS16655	COG1595	DNA-templated transcription, initiation
FHE72_RS16675	COG3896	Chloramphenicol phosphotransferase-like protein
FHE72_RS16680	COG2226	methyltransferase
FHE72_RS16705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHE72_RS16785	COG0028	Belongs to the TPP enzyme family
FHE72_RS16790	COG3848	Pyruvate phosphate dikinase
FHE72_RS16790	COG0574	Belongs to the PEP-utilizing enzyme family
FHE72_RS16835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FHE72_RS16850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHE72_RS16865	COG0596	Alpha beta hydrolase
FHE72_RS16890	COG2226	methyltransferase
FHE72_RS16895	COG1506	peptidase
FHE72_RS16895	COG0823	Involved in the tonB-independent uptake of proteins
FHE72_RS16905	COG1214	PFAM Peptidase M22, glycoprotease
FHE72_RS16905	COG0456	acetyltransferase
FHE72_RS16930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHE72_RS16950	COG1162	GTPase activity
FHE72_RS16960	COG1051	belongs to the nudix hydrolase family
FHE72_RS17025	COG0346	lactoylglutathione lyase activity
FHE72_RS17035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FHE72_RS17045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHE72_RS17100	COG0510	thiamine kinase activity
FHE72_RS17140	COG1619	proteins homologs of microcin C7 resistance protein MccF
FHE72_RS17210	COG0656	L-ascorbic acid biosynthetic process
FHE72_RS17235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHE72_RS17245	COG2367	Beta-lactamase
FHE72_RS17260	COG3328	transposase activity
FHE72_RS17285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FHE72_RS17295	COG4109	DRTGG domain
FHE72_RS17330	COG1733	regulation of RNA biosynthetic process
FHE72_RS17335	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FHE72_RS17340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FHE72_RS17390	COG1879	ABC-type sugar transport system periplasmic component
FHE72_RS17395	COG1172	Belongs to the binding-protein-dependent transport system permease family
FHE72_RS17400	COG1129	ABC transporter
FHE72_RS17405	COG1869	D-ribose catabolic process
FHE72_RS17410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHE72_RS17440	COG0584	glycerophosphoryl diester phosphodiesterase
FHE72_RS17445	COG0693	protein deglycase activity
FHE72_RS17450	COG1316	TRANSCRIPTIONal
FHE72_RS17460	COG1595	DNA-templated transcription, initiation
FHE72_RS17485	COG1683	Conserved Protein
FHE72_RS17490	COG1794	racemase activity, acting on amino acids and derivatives
FHE72_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS17520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHE72_RS17525	COG0577	efflux transmembrane transporter activity
FHE72_RS17525	COG1136	(ABC) transporter
FHE72_RS17530	COG2814	Major facilitator Superfamily
FHE72_RS17535	COG1819	glycosyl
FHE72_RS17560	COG1464	Belongs to the NlpA lipoprotein family
FHE72_RS17565	COG2011	ABC-type metal ion transport system permease component
FHE72_RS17575	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FHE72_RS17580	COG1285	pathogenesis
FHE72_RS17610	COG0714	Associated with various cellular activities
FHE72_RS17640	COG2508	Transcriptional regulator
FHE72_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS17650	COG0506	proline dehydrogenase activity
FHE72_RS17665	COG0647	UMP catabolic process
FHE72_RS17670	COG1234	tRNA 3'-trailer cleavage
FHE72_RS17680	COG1175	transmembrane transport
FHE72_RS17685	COG1653	transport
FHE72_RS17690	COG1285	pathogenesis
FHE72_RS17715	COG1595	DNA-templated transcription, initiation
FHE72_RS17750	COG1473	amidohydrolase
FHE72_RS17770	COG2267	carboxylic ester hydrolase activity
FHE72_RS17775	COG3328	transposase activity
FHE72_RS17785	COG0640	Transcriptional regulator
FHE72_RS17790	COG1612	heme a metabolic process
FHE72_RS17815	COG3541	Predicted nucleotidyltransferase
FHE72_RS17825	COG5002	protein histidine kinase activity
FHE72_RS17830	COG0745	RESPONSE REGULATOR receiver
FHE72_RS17870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FHE72_RS17945	COG1846	Transcriptional regulator
FHE72_RS17960	COG0589	response to stress
FHE72_RS17970	COG0137	argininosuccinate synthase activity
FHE72_RS17980	COG2217	Heavy metal translocating P-type atpase
FHE72_RS17985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FHE72_RS17990	COG0827	DNA restriction-modification system
FHE72_RS17995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FHE72_RS18000	COG3874	Sporulation protein YtfJ
FHE72_RS18010	COG1714	RDD family
FHE72_RS18015	COG0616	signal peptide processing
FHE72_RS18020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FHE72_RS18025	COG2962	Rard protein
FHE72_RS18035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FHE72_RS18045	COG0301	tRNA thio-modification
FHE72_RS18055	COG1114	Component of the transport system for branched-chain amino acids
FHE72_RS18060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FHE72_RS18065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FHE72_RS18070	COG1309	transcriptional regulator
FHE72_RS18075	COG1956	GAF domain-containing protein
FHE72_RS18085	COG3689	TIGRFAM TIGR03943 family protein
FHE72_RS18095	COG0701	Predicted permease
FHE72_RS18100	COG0523	cobalamin synthesis protein
FHE72_RS18120	COG2203	Gaf domain
FHE72_RS18120	COG2199	diguanylate cyclase activity
FHE72_RS18130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FHE72_RS18145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FHE72_RS18150	COG0454	-acetyltransferase
FHE72_RS18155	COG0517	IMP dehydrogenase activity
FHE72_RS18160	COG0123	including yeast histone deacetylase and acetoin utilization protein
FHE72_RS18170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FHE72_RS18180	COG1763	Mo-molybdopterin cofactor biosynthetic process
FHE72_RS18185	COG0315	cyclic pyranopterin monophosphate synthase activity
FHE72_RS18190	COG4149	molybdate abc transporter
FHE72_RS18195	COG0725	ABC transporter, periplasmic molybdate-binding protein
FHE72_RS18205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FHE72_RS18210	COG0314	molybdopterin synthase activity
FHE72_RS18215	COG0303	'Molybdopterin
FHE72_RS18220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FHE72_RS18225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FHE72_RS18230	COG3383	formate dehydrogenase (NAD+) activity
FHE72_RS18245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FHE72_RS18255	COG1605	Chorismate mutase
FHE72_RS18255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FHE72_RS18260	COG0849	cell division
FHE72_RS18275	COG4980	gas vesicle protein
FHE72_RS18285	COG2309	aminopeptidase activity
FHE72_RS18305	COG1674	ftsk spoiiie
FHE72_RS18310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHE72_RS18315	COG4848	Belongs to the UPF0354 family
FHE72_RS18320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS18340	COG3104	oligopeptide transport
FHE72_RS18350	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FHE72_RS18355	COG1363	Peptidase, m42
FHE72_RS18365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FHE72_RS18370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FHE72_RS18380	COG0510	thiamine kinase activity
FHE72_RS18385	COG1523	belongs to the glycosyl hydrolase 13 family
FHE72_RS18400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHE72_RS18415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHE72_RS18420	COG1349	DNA-binding transcription factor activity
FHE72_RS18425	COG1187	pseudouridine synthase activity
FHE72_RS18430	COG2244	polysaccharide biosynthetic process
FHE72_RS18435	COG2081	HI0933 family
FHE72_RS18445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHE72_RS18450	COG0495	leucyl-tRNA aminoacylation
FHE72_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS18460	COG2610	gluconate transmembrane transporter activity
FHE72_RS18465	COG3290	protein histidine kinase activity
FHE72_RS18465	COG3829	transcription factor binding
FHE72_RS18475	COG2814	Major facilitator Superfamily
FHE72_RS18490	COG1242	4 iron, 4 sulfur cluster binding
FHE72_RS18495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FHE72_RS18500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHE72_RS18515	COG2267	carboxylic ester hydrolase activity
FHE72_RS18520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FHE72_RS18525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FHE72_RS18545	COG1268	BioY protein
FHE72_RS18560	COG1506	peptidase
FHE72_RS18565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FHE72_RS18570	COG1116	anion transmembrane transporter activity
FHE72_RS18575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHE72_RS18590	COG4824	toxin secretion phage lysis holin
FHE72_RS18610	COG1854	S-ribosylhomocysteine lyase activity
FHE72_RS18615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FHE72_RS18625	COG1271	oxidase subunit
FHE72_RS18630	COG1294	oxidase, subunit
FHE72_RS18635	COG0300	oxidoreductase activity
FHE72_RS18640	COG4948	Mandelate Racemase Muconate Lactonizing
FHE72_RS18645	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS18650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FHE72_RS18655	COG0596	Alpha beta hydrolase
FHE72_RS18660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FHE72_RS18665	COG1169	isochorismate synthase
FHE72_RS18670	COG1575	Belongs to the MenA family. Type 1 subfamily
FHE72_RS18675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FHE72_RS18680	COG0058	SHG alpha-glucan phosphorylase activity
FHE72_RS18685	COG0297	glycogen (starch) synthase activity
FHE72_RS18690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FHE72_RS18835	COG1285	pathogenesis
FHE72_RS18840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHE72_RS18840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHE72_RS18840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHE72_RS18845	COG1105	Belongs to the carbohydrate kinase PfkB family
FHE72_RS18850	COG1349	DNA-binding transcription factor activity
FHE72_RS18855	COG1368	sulfuric ester hydrolase activity
FHE72_RS18865	COG0561	phosphatase activity
FHE72_RS18870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHE72_RS18875	COG4821	SIS domain
FHE72_RS18885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHE72_RS18885	COG1263	PTS System
FHE72_RS18890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FHE72_RS18895	COG0363	glucosamine-6-phosphate deaminase activity
FHE72_RS18905	COG4974	Belongs to the 'phage' integrase family
FHE72_RS19075	COG2132	Multicopper oxidase
FHE72_RS19085	COG1388	LysM domain
FHE72_RS19090	COG5002	protein histidine kinase activity
FHE72_RS19095	COG0745	RESPONSE REGULATOR receiver
FHE72_RS19120	COG2132	Multicopper oxidase
FHE72_RS19135	COG2217	Heavy metal translocating P-type atpase
FHE72_RS19140	COG2608	mercury ion transmembrane transporter activity
FHE72_RS19155	COG4608	Belongs to the ABC transporter superfamily
FHE72_RS19160	COG0444	Belongs to the ABC transporter superfamily
FHE72_RS19165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHE72_RS19170	COG0601	transmembrane transport
FHE72_RS19175	COG4533	DNA binding
FHE72_RS19200	COG0534	Mate efflux family protein
FHE72_RS19230	COG1999	signal sequence binding
FHE72_RS19240	COG0640	Transcriptional regulator
FHE72_RS19255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FHE72_RS19260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FHE72_RS19265	COG1742	UPF0060 membrane protein
FHE72_RS19270	COG1368	sulfuric ester hydrolase activity
FHE72_RS19295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FHE72_RS19300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FHE72_RS19305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS19310	COG0785	Cytochrome C biogenesis protein
FHE72_RS19340	COG2072	flavoprotein involved in K transport
FHE72_RS19345	COG2304	oxidoreductase activity
FHE72_RS19355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHE72_RS19360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FHE72_RS19375	COG1979	alcohol dehydrogenase
FHE72_RS19380	COG2155	Conserved Protein
FHE72_RS19385	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS19390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHE72_RS19395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FHE72_RS19400	COG3829	transcription factor binding
FHE72_RS19410	COG1012	belongs to the aldehyde dehydrogenase family
FHE72_RS19420	COG1098	S1 RNA binding domain
FHE72_RS19430	COG0733	neurotransmitter:sodium symporter activity
FHE72_RS19435	COG1396	sequence-specific DNA binding
FHE72_RS19440	COG0436	Aminotransferase
FHE72_RS19445	COG1522	sequence-specific DNA binding
FHE72_RS19450	COG2267	carboxylic ester hydrolase activity
FHE72_RS19455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FHE72_RS19460	COG2032	superoxide dismutase activity
FHE72_RS19470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FHE72_RS19480	COG5018	Exonuclease
FHE72_RS19485	COG2814	Major facilitator Superfamily
FHE72_RS19490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHE72_RS19515	COG1006	Multisubunit Na H antiporter MnhC subunit
FHE72_RS19520	COG0651	ATP synthesis coupled electron transport
FHE72_RS19525	COG1863	multisubunit Na H antiporter MnhE subunit
FHE72_RS19530	COG2212	antiporter activity
FHE72_RS19540	COG4876	unkown
FHE72_RS19545	COG2050	protein possibly involved in aromatic compounds catabolism
FHE72_RS19555	COG2056	Na+-H+ antiporter family
FHE72_RS19560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FHE72_RS19565	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FHE72_RS19570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FHE72_RS19575	COG3588	fructose-bisphosphate aldolase
FHE72_RS19580	COG3584	3D domain protein
FHE72_RS19600	COG1252	NADH dehydrogenase
FHE72_RS19610	COG0702	epimerase
FHE72_RS19615	COG0316	Belongs to the HesB IscA family
FHE72_RS19630	COG1252	NADH dehydrogenase
FHE72_RS19635	COG2124	cytochrome p450
FHE72_RS19640	COG4837	Protein of unknown function (DUF1462)
FHE72_RS19645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FHE72_RS19650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FHE72_RS19655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FHE72_RS19660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FHE72_RS19675	COG0647	UMP catabolic process
FHE72_RS19680	COG2445	Protein of unknown function DUF86
FHE72_RS19695	COG4470	Protein conserved in bacteria
FHE72_RS19710	COG0739	heme binding
FHE72_RS19720	COG0733	neurotransmitter:sodium symporter activity
FHE72_RS19725	COG1757	Na H antiporter
FHE72_RS19740	COG3377	Domain of unknown function (DUF1805)
FHE72_RS19745	COG0737	Belongs to the 5'-nucleotidase family
FHE72_RS19750	COG0730	response to heat
FHE72_RS19755	COG1801	Protein of unknown function DUF72
FHE72_RS19760	COG0719	Fe-S assembly protein
FHE72_RS19765	COG0822	iron-sulfur transferase activity
FHE72_RS19770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FHE72_RS19775	COG0719	Fe-S assembly protein
FHE72_RS19780	COG0396	ATPase activity
FHE72_RS19785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FHE72_RS19790	COG1464	Belongs to the NlpA lipoprotein family
FHE72_RS19795	COG2011	ABC-type metal ion transport system permease component
FHE72_RS19800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHE72_RS19810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS19815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FHE72_RS19825	COG0509	glycine decarboxylation via glycine cleavage system
FHE72_RS19830	COG1393	Belongs to the ArsC family
FHE72_RS19840	COG0300	oxidoreductase activity
FHE72_RS19845	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS19850	COG0183	Belongs to the thiolase family
FHE72_RS19855	COG1024	Enoyl-CoA hydratase
FHE72_RS19855	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHE72_RS19865	COG2364	Membrane
FHE72_RS19890	COG5577	PFAM Coat F domain
FHE72_RS19905	COG1120	ATPase activity
FHE72_RS19910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHE72_RS19915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHE72_RS19920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FHE72_RS19940	COG0673	inositol 2-dehydrogenase activity
FHE72_RS19945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS19975	COG1785	Belongs to the alkaline phosphatase family
FHE72_RS19980	COG1834	amidinotransferase
FHE72_RS19985	COG0318	PFAM AMP-dependent synthetase and ligase
FHE72_RS20005	COG1979	alcohol dehydrogenase
FHE72_RS20010	COG0583	DNA-binding transcription factor activity
FHE72_RS20015	COG0655	NAD(P)H dehydrogenase (quinone) activity
FHE72_RS20025	COG1846	Transcriptional regulator
FHE72_RS20030	COG1764	response to oxidative stress
FHE72_RS20040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS20040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS20060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHE72_RS20065	COG2514	catechol 2,3-dioxygenase activity
FHE72_RS20070	COG1733	regulation of RNA biosynthetic process
FHE72_RS20090	COG2814	Major facilitator Superfamily
FHE72_RS20110	COG1733	regulation of RNA biosynthetic process
FHE72_RS20120	COG3227	Zinc metalloprotease (Elastase)
FHE72_RS20125	COG3706	GGDEF domain
FHE72_RS20145	COG1113	amino acid transport
FHE72_RS20150	COG3403	YqcI/YcgG family
FHE72_RS20160	COG5577	PFAM Coat F domain
FHE72_RS20165	COG1376	ErfK ybiS ycfS ynhG family protein
FHE72_RS20170	COG0527	aspartate kinase activity
FHE72_RS20190	COG1027	Aspartate ammonia-lyase
FHE72_RS20210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FHE72_RS20220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FHE72_RS20230	COG2132	Multicopper oxidase
FHE72_RS20245	COG2217	Heavy metal translocating P-type atpase
FHE72_RS20255	COG3682	Transcriptional regulator
FHE72_RS20260	COG1388	LysM domain
FHE72_RS20265	COG5002	protein histidine kinase activity
FHE72_RS20270	COG0745	RESPONSE REGULATOR receiver
FHE72_RS20285	COG0701	Predicted permease
FHE72_RS20300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FHE72_RS20305	COG0557	exoribonuclease II activity
FHE72_RS20310	COG1647	Serine aminopeptidase, S33
FHE72_RS20315	COG3344	reverse transcriptase
FHE72_RS20320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FHE72_RS20325	COG0148	phosphopyruvate hydratase activity
FHE72_RS20360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FHE72_RS20365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FHE72_RS20370	COG2314	TM2 domain
FHE72_RS20380	COG1715	Restriction endonuclease
FHE72_RS20485	COG4974	Belongs to the 'phage' integrase family
FHE72_RS20500	COG5002	protein histidine kinase activity
FHE72_RS20505	COG0745	RESPONSE REGULATOR receiver
FHE72_RS20525	COG3706	GGDEF domain
FHE72_RS20530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHE72_RS20540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FHE72_RS20545	COG1660	Displays ATPase and GTPase activities
FHE72_RS20550	COG1051	belongs to the nudix hydrolase family
FHE72_RS20570	COG0492	ferredoxin-NADP+ reductase activity
FHE72_RS20575	COG0457	Tetratricopeptide repeat
FHE72_RS20580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FHE72_RS20580	COG0140	phosphoribosyl-ATP diphosphatase activity
FHE72_RS20585	COG0107	imidazoleglycerol-phosphate synthase activity
FHE72_RS20590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FHE72_RS20595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FHE72_RS20600	COG0131	Imidazoleglycerol-phosphate dehydratase
FHE72_RS20605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FHE72_RS20610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FHE72_RS20615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FHE72_RS20620	COG0110	maltose O-acetyltransferase activity
FHE72_RS20625	COG0546	phosphoglycolate phosphatase activity
FHE72_RS20630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FHE72_RS20635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FHE72_RS20640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FHE72_RS20650	COG1950	PFAM Membrane protein of
FHE72_RS20660	COG3595	metallopeptidase activity
FHE72_RS20670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FHE72_RS20675	COG0556	nucleotide-excision repair
FHE72_RS20685	COG4897	Protein conserved in bacteria
FHE72_RS20690	COG0751	glycine-tRNA ligase activity
FHE72_RS20695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FHE72_RS20705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHE72_RS20710	COG0569	domain protein
FHE72_RS20720	COG1301	dicarboxylic acid transport
FHE72_RS20725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHE72_RS20730	COG3243	poly(R)-hydroxyalkanoic acid synthase
FHE72_RS20740	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS20745	COG3409	Peptidoglycan-binding domain 1 protein
FHE72_RS20745	COG0793	Belongs to the peptidase S41A family
FHE72_RS20750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FHE72_RS20760	COG0626	cystathionine gamma-synthase activity
FHE72_RS20770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHE72_RS20780	COG5002	protein histidine kinase activity
FHE72_RS20790	COG0785	Cytochrome C biogenesis protein
FHE72_RS20805	COG0739	heme binding
FHE72_RS20810	COG2177	Part of the ABC transporter FtsEX involved in
FHE72_RS20815	COG2884	Cell division ATP-binding protein ftsE
FHE72_RS20825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHE72_RS20835	COG0653	protein targeting
FHE72_RS20840	COG1405	negative regulation of cell septum assembly
FHE72_RS20840	COG3012	SEC-C Motif Domain Protein
FHE72_RS20860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FHE72_RS20880	COG1516	flagellar protein fliS
FHE72_RS20885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FHE72_RS20890	COG1334	flagellar protein FlaG
FHE72_RS20905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FHE72_RS20915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FHE72_RS20920	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FHE72_RS20930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FHE72_RS20935	COG4786	Flagellar basal body rod
FHE72_RS20935	COG1256	bacterial-type flagellum assembly
FHE72_RS20960	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FHE72_RS20975	COG0737	Belongs to the 5'-nucleotidase family
FHE72_RS20980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FHE72_RS21005	COG0346	lactoylglutathione lyase activity
FHE72_RS21010	COG1227	inorganic diphosphatase activity
FHE72_RS21015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FHE72_RS21020	COG3290	protein histidine kinase activity
FHE72_RS21025	COG4565	transcriptional regulatory protein
FHE72_RS21045	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS21055	COG0768	penicillin binding
FHE72_RS21065	COG0737	Belongs to the 5'-nucleotidase family
FHE72_RS21075	COG0653	protein targeting
FHE72_RS21085	COG2011	ABC-type metal ion transport system permease component
FHE72_RS21090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHE72_RS21095	COG1609	Transcriptional regulator
FHE72_RS21100	COG0366	Alpha amylase catalytic
FHE72_RS21105	COG0395	ABC-type sugar transport system, permease component
FHE72_RS21110	COG1175	transmembrane transport
FHE72_RS21115	COG2182	Extracellular solute-binding protein
FHE72_RS21125	COG3459	Glycosyltransferase 36 associated
FHE72_RS21130	COG3394	polysaccharide catabolic process
FHE72_RS21140	COG1486	melibiose metabolic process
FHE72_RS21145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHE72_RS21150	COG1447	Phosphotransferase system cellobiose-specific component IIA
FHE72_RS21155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHE72_RS21170	COG1511	domain protein
FHE72_RS21175	COG1511	domain protein
FHE72_RS21175	COG1511	domain protein
FHE72_RS21180	COG1309	transcriptional regulator
FHE72_RS21185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHE72_RS21210	COG1999	signal sequence binding
FHE72_RS21225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHE72_RS21230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FHE72_RS21250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHE72_RS21250	COG1263	PTS System
FHE72_RS21255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FHE72_RS21265	COG4974	Belongs to the 'phage' integrase family
FHE72_RS21445	COG0606	chelatase, subunit chli
FHE72_RS21515	COG3227	Zinc metalloprotease (Elastase)
FHE72_RS21525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FHE72_RS21545	COG3458	cephalosporin-C deacetylase activity
FHE72_RS21555	COG0673	inositol 2-dehydrogenase activity
FHE72_RS21560	COG0673	inositol 2-dehydrogenase activity
FHE72_RS21590	COG0395	ABC-type sugar transport system, permease component
FHE72_RS21600	COG1653	transport
FHE72_RS21605	COG5578	integral membrane protein
FHE72_RS21630	COG2814	Major facilitator Superfamily
FHE72_RS21635	COG0583	DNA-binding transcription factor activity
FHE72_RS21690	COG1131	(ABC) transporter
FHE72_RS21695	COG1131	(ABC) transporter
FHE72_RS21705	COG3012	SEC-C Motif Domain Protein
FHE72_RS21735	COG0840	transmembrane signaling receptor activity
FHE72_RS21740	COG1802	Transcriptional regulator
FHE72_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS21765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHE72_RS21770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FHE72_RS21775	COG3250	beta-galactosidase activity
FHE72_RS21780	COG1609	Transcriptional regulator
FHE72_RS21785	COG0395	ABC-type sugar transport system, permease component
FHE72_RS21795	COG2182	Extracellular solute-binding protein
FHE72_RS21805	COG1316	TRANSCRIPTIONal
FHE72_RS21815	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS21815	COG2247	cell wall binding repeat
FHE72_RS21840	COG2755	lipolytic protein G-D-S-L family
FHE72_RS21840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FHE72_RS21845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHE72_RS21850	COG1215	transferase activity, transferring glycosyl groups
FHE72_RS21855	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS21860	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS21875	COG0438	transferase activity, transferring glycosyl groups
FHE72_RS21885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FHE72_RS21890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHE72_RS21895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FHE72_RS21900	COG4464	protein tyrosine phosphatase activity
FHE72_RS21905	COG0489	protein tyrosine kinase activity
FHE72_RS21910	COG3944	biosynthesis protein
FHE72_RS21930	COG1388	LysM domain
FHE72_RS21930	COG0791	NLP P60 protein
FHE72_RS21940	COG1263	PTS System
FHE72_RS21940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHE72_RS21945	COG0366	Alpha amylase catalytic
FHE72_RS21975	COG2188	Transcriptional regulator
FHE72_RS22000	COG2197	response regulator
FHE72_RS22005	COG4585	Histidine kinase
FHE72_RS22010	COG1739	Uncharacterized protein family UPF0029
FHE72_RS22015	COG1316	TRANSCRIPTIONal
FHE72_RS22025	COG3307	-O-antigen
FHE72_RS22030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FHE72_RS22070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHE72_RS22080	COG2247	cell wall binding repeat
FHE72_RS22080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS22085	COG0860	N-Acetylmuramoyl-L-alanine amidase
FHE72_RS22085	COG2247	cell wall binding repeat
FHE72_RS22090	COG2385	sporulation resulting in formation of a cellular spore
FHE72_RS22090	COG2247	cell wall binding repeat
FHE72_RS22105	COG0791	NLP P60 protein
FHE72_RS22105	COG1388	LysM domain
FHE72_RS22120	COG0010	Belongs to the arginase family
FHE72_RS22130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FHE72_RS22135	COG2986	histidine ammonia-lyase
FHE72_RS22175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FHE72_RS22185	COG1785	Belongs to the alkaline phosphatase family
FHE72_RS22190	COG4715	Zinc finger, swim domain protein
FHE72_RS22195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FHE72_RS22205	COG0629	single-stranded DNA binding
FHE72_RS22215	COG1396	sequence-specific DNA binding
FHE72_RS22240	COG4786	Flagellar basal body rod
FHE72_RS22245	COG4786	Flagellar basal body rod
FHE72_RS22255	COG1609	Transcriptional regulator
FHE72_RS22260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FHE72_RS22275	COG0739	heme binding
FHE72_RS22285	COG2385	sporulation resulting in formation of a cellular spore
FHE72_RS22290	COG3328	transposase activity
FHE72_RS22300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FHE72_RS22310	COG4836	Membrane
FHE72_RS22335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FHE72_RS22350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FHE72_RS22360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FHE72_RS22365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHE72_RS22375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHE72_RS22380	COG0356	it plays a direct role in the translocation of protons across the membrane
FHE72_RS22395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FHE72_RS22400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FHE72_RS22405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FHE72_RS22415	COG0698	ribose 5-phosphate isomerase
FHE72_RS22420	COG0840	transmembrane signaling receptor activity
FHE72_RS22435	COG0009	L-threonylcarbamoyladenylate synthase
FHE72_RS22450	COG2890	protein-(glutamine-N5) methyltransferase activity
FHE72_RS22455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FHE72_RS22465	COG1435	thymidine kinase activity
FHE72_RS22475	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FHE72_RS22485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FHE72_RS22490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FHE72_RS22495	COG0191	fructose-bisphosphate aldolase activity
FHE72_RS22500	COG2204	response regulator
FHE72_RS22505	COG4821	SIS domain
FHE72_RS22510	COG1172	Belongs to the binding-protein-dependent transport system permease family
FHE72_RS22515	COG1129	ABC transporter
FHE72_RS22525	COG0504	CTP synthase activity
FHE72_RS22540	COG1703	isobutyryl-CoA mutase activity
FHE72_RS22540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FHE72_RS22540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FHE72_RS22550	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS22555	COG1960	acyl-CoA dehydrogenase activity
FHE72_RS22560	COG1250	3-hydroxyacyl-CoA dehydrogenase
FHE72_RS22565	COG0183	Belongs to the thiolase family
FHE72_RS22570	COG0247	lactate metabolic process
FHE72_RS22570	COG2181	nitrate reductase activity
FHE72_RS22575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHE72_RS22590	COG0018	arginyl-trna synthetase
FHE72_RS22595	COG4506	Protein conserved in bacteria
FHE72_RS22600	COG0010	Belongs to the arginase family
FHE72_RS22605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FHE72_RS22610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHE72_RS22620	COG1994	Peptidase M50
FHE72_RS22635	COG3465	dGTPase activity
FHE72_RS22640	COG1078	dGTPase activity
FHE72_RS22660	COG0280	phosphate acetyltransferase
FHE72_RS22670	COG3773	Cell wall hydrolase
FHE72_RS22680	COG2363	Small membrane protein
FHE72_RS22690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FHE72_RS22705	COG0351	phosphomethylpyrimidine kinase
FHE72_RS22710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FHE72_RS22720	COG1131	(ABC) transporter
FHE72_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS22745	COG1191	sigma factor activity
FHE72_RS22780	COG0561	phosphatase activity
FHE72_RS22790	COG2031	fatty acid transporter
FHE72_RS22810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FHE72_RS22820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FHE72_RS22830	COG2364	Membrane
FHE72_RS22845	COG0300	oxidoreductase activity
FHE72_RS22850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FHE72_RS22855	COG0723	plastoquinol--plastocyanin reductase activity
FHE72_RS22855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FHE72_RS22865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS22865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHE72_RS22875	COG2910	NAD(P)H-binding
FHE72_RS22900	COG3835	regulator
FHE72_RS22905	COG3835	regulator
FHE72_RS22910	COG1929	Belongs to the glycerate kinase type-1 family
FHE72_RS22915	COG2610	gluconate transmembrane transporter activity
FHE72_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
FHE72_RS23010	COG0583	DNA-binding transcription factor activity
FHE72_RS23025	COG1511	domain protein
FHE72_RS23030	COG1674	ftsk spoiiie
FHE72_RS23030	COG0433	COG0433 Predicted ATPase
FHE72_RS23035	COG4499	WXG100 protein secretion system (Wss), protein YukC
FHE72_RS23040	COG5417	Belongs to the EsaB family
FHE72_RS23045	COG4842	Belongs to the WXG100 family
FHE72_RS23055	COG0745	RESPONSE REGULATOR receiver
FHE72_RS23060	COG0642	Histidine kinase
FHE72_RS23065	COG1136	(ABC) transporter
FHE72_RS23070	COG0577	efflux transmembrane transporter activity
FHE72_RS23100	COG2814	Major facilitator Superfamily
FHE72_RS23110	COG4682	membrane
FHE72_RS23115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FHE72_RS23125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHE72_RS23140	COG1113	amino acid transport
FHE72_RS23145	COG3328	transposase activity
FHE72_RS23170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHE72_RS23175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FHE72_RS23180	COG4853	Protein conserved in bacteria
FHE72_RS23185	COG4863	YycH protein
FHE72_RS23190	COG5002	protein histidine kinase activity
FHE72_RS23195	COG0745	RESPONSE REGULATOR receiver
FHE72_RS23200	COG0739	heme binding
FHE72_RS23235	COG0754	glutathionylspermidine amidase activity
FHE72_RS23250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FHE72_RS23255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FHE72_RS23265	COG0305	Participates in initiation and elongation during chromosome replication
FHE72_RS23270	COG0359	binds to the 23S rRNA
FHE72_RS23275	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FHE72_RS23280	COG4241	membrane
FHE72_RS23285	COG0840	transmembrane signaling receptor activity
FHE72_RS23290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FHE72_RS23295	COG0629	single-stranded DNA binding
FHE72_RS23300	COG0360	Binds together with S18 to 16S ribosomal RNA
FHE72_RS23305	COG0012	GTP binding
FHE72_RS23310	COG4481	Protein conserved in bacteria
FHE72_RS23315	COG0668	transmembrane transport
FHE72_RS23330	COG1475	DNA binding
FHE72_RS23335	COG1192	Involved in chromosome partitioning
FHE72_RS23340	COG1475	DNA binding
FHE72_RS23355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FHE72_RS23360	COG1847	R3H domain protein
FHE72_RS23370	COG0594	ribonuclease P activity
FHE72_RS23375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FHE72_RS23450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHE72_RS23540	COG0740	serine-type endopeptidase activity
FHE72_RS23575	COG0582	viral genome integration into host DNA