locus-tag	class	description
I5776_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5776_RS00010	COG0592	DNA-directed DNA polymerase activity
I5776_RS00015	COG2501	S4 domain
I5776_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5776_RS00030	COG0187	DNA topoisomerase II activity
I5776_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5776_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5776_RS00075	COG0516	GMP reductase activity
I5776_RS00075	COG0517	IMP dehydrogenase activity
I5776_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I5776_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I5776_RS00100	COG1428	Deoxynucleoside kinase
I5776_RS00105	COG1428	Deoxynucleoside kinase
I5776_RS00110	COG3858	chitin binding
I5776_RS00110	COG1388	LysM domain
I5776_RS00115	COG0590	tRNA wobble adenosine to inosine editing
I5776_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5776_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5776_RS00175	COG1982	Orn Lys Arg decarboxylase major
I5776_RS00180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5776_RS00185	COG3870	Protein conserved in bacteria
I5776_RS00190	COG1728	Protein conserved in bacteria
I5776_RS00195	COG0470	DNA polymerase III
I5776_RS00200	COG1774	PSP1 C-terminal conserved region
I5776_RS00205	COG4467	Involved in initiation control of chromosome replication
I5776_RS00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5776_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5776_RS00220	COG2002	toxin-antitoxin pair type II binding
I5776_RS00230	COG0084	hydrolase, TatD family'
I5776_RS00235	COG3584	3D domain protein
I5776_RS00235	COG3583	domain protein
I5776_RS00255	COG4466	Protein conserved in bacteria
I5776_RS00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5776_RS00275	COG0251	oxidation-reduction process
I5776_RS00280	COG2088	sporulation resulting in formation of a cellular spore
I5776_RS00285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5776_RS00290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5776_RS00295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5776_RS00310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5776_RS00315	COG2002	toxin-antitoxin pair type II binding
I5776_RS00320	COG2244	polysaccharide biosynthetic process
I5776_RS00325	COG3956	TIGRFAM MazG family protein
I5776_RS00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5776_RS00350	COG1098	S1 RNA binding domain
I5776_RS00370	COG2208	phosphoserine phosphatase activity
I5776_RS00375	COG2304	oxidoreductase activity
I5776_RS00380	COG0515	serine threonine protein kinase
I5776_RS00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5776_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5776_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5776_RS00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5776_RS00410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5776_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5776_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5776_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5776_RS00430	COG1396	sequence-specific DNA binding
I5776_RS00520	COG3880	PFAM UvrB UvrC protein
I5776_RS00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I5776_RS00530	COG0542	response to heat
I5776_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5776_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
I5776_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5776_RS00555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5776_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5776_RS00565	COG1045	serine acetyltransferase
I5776_RS00570	COG0215	cysteine-tRNA ligase activity
I5776_RS00575	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I5776_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5776_RS00585	COG3688	RNA-binding protein containing a PIN domain
I5776_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5776_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5776_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
I5776_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5776_RS00615	COG0081	regulation of translation
I5776_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5776_RS00625	COG0222	ribosome binding
I5776_RS00630	COG2813	Specifically methylates the guanine in position
I5776_RS00635	COG0085	RNA polymerase activity
I5776_RS00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5776_RS00645	COG1358	cellular component organization or biogenesis
I5776_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5776_RS00655	COG0049	tRNA binding
I5776_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5776_RS00670	COG0051	transcription antitermination factor activity, RNA binding
I5776_RS00680	COG0088	Forms part of the polypeptide exit tunnel
I5776_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5776_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5776_RS00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5776_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5776_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
I5776_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5776_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5776_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5776_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5776_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5776_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5776_RS00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5776_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5776_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5776_RS00765	COG1841	ribosomal large subunit assembly
I5776_RS00775	COG0201	protein transport
I5776_RS00780	COG0563	adenylate kinase activity
I5776_RS00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5776_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5776_RS00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5776_RS00810	COG0202	RNA polymerase activity
I5776_RS00815	COG0203	ribosomal protein L17
I5776_RS00825	COG1122	ATPase activity
I5776_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5776_RS00835	COG0101	tRNA pseudouridine synthase activity
I5776_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5776_RS00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5776_RS00870	COG1674	ftsk spoiiie
I5776_RS00885	COG2003	Belongs to the UPF0758 family
I5776_RS00890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I5776_RS00895	COG3421	Type III restriction
I5776_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS00915	COG0489	protein tyrosine kinase activity
I5776_RS00930	COG2194	sulfuric ester hydrolase activity
I5776_RS00935	COG0726	polysaccharide deacetylase
I5776_RS01000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5776_RS01015	COG1595	DNA-templated transcription, initiation
I5776_RS01020	COG5662	AntiSigma factor
I5776_RS01025	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I5776_RS01030	COG4856	YbbR-like protein
I5776_RS01035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5776_RS01040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5776_RS01080	COG0640	Transcriptional regulator
I5776_RS01085	COG0798	PFAM Bile acid sodium symporter
I5776_RS01090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5776_RS01200	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5776_RS01210	COG2378	regulation of single-species biofilm formation
I5776_RS01220	COG0798	PFAM Bile acid sodium symporter
I5776_RS01225	COG0640	Transcriptional regulator
I5776_RS01230	COG2318	DinB family
I5776_RS01260	COG1279	arginine transmembrane transporter activity
I5776_RS01275	COG1309	transcriptional regulator
I5776_RS01300	COG0385	Bile acid
I5776_RS01310	COG3279	Response regulator of the LytR AlgR family
I5776_RS01325	COG0789	Transcriptional regulator
I5776_RS01365	COG2207	Transcriptional regulator
I5776_RS01375	COG5416	Lipopolysaccharide assembly protein A domain
I5776_RS01380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS01400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5776_RS01405	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I5776_RS01410	COG1114	Component of the transport system for branched-chain amino acids
I5776_RS01415	COG1802	Transcriptional regulator
I5776_RS01420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS01455	COG2207	Transcriptional regulator
I5776_RS01455	COG3708	Transcriptional regulator
I5776_RS01470	COG1132	(ABC) transporter
I5776_RS01475	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5776_RS01480	COG0583	DNA-binding transcription factor activity
I5776_RS01495	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I5776_RS01520	COG2807	transmembrane transport
I5776_RS01525	COG2186	Transcriptional regulator
I5776_RS01540	COG0840	transmembrane signaling receptor activity
I5776_RS01545	COG0824	Thioesterase
I5776_RS01555	COG1609	Transcriptional regulator
I5776_RS01560	COG4912	Dna alkylation repair
I5776_RS01565	COG0765	amino acid transport
I5776_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS01595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5776_RS01600	COG2378	regulation of single-species biofilm formation
I5776_RS01610	COG3708	Transcriptional regulator
I5776_RS01620	COG2197	response regulator
I5776_RS01625	COG4585	Histidine kinase
I5776_RS01630	COG0842	Transport permease protein
I5776_RS01635	COG1131	(ABC) transporter
I5776_RS01645	COG2270	Major facilitator Superfamily
I5776_RS01650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5776_RS01665	COG0423	glycine-tRNA ligase activity
I5776_RS01675	COG0833	amino acid
I5776_RS01680	COG0531	amino acid
I5776_RS01685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5776_RS01690	COG0628	permease
I5776_RS01695	COG3584	3D domain protein
I5776_RS01695	COG1388	LysM domain
I5776_RS01700	COG1126	abc transporter atp-binding protein
I5776_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS01710	COG0765	amino acid transport
I5776_RS01715	COG0765	amino acid transport
I5776_RS01720	COG0628	permease
I5776_RS01725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5776_RS01735	COG0791	NLP P60 protein
I5776_RS01740	COG1733	regulation of RNA biosynthetic process
I5776_RS01755	COG1131	(ABC) transporter
I5776_RS01770	COG1346	cytolysis
I5776_RS01780	COG0583	DNA-binding transcription factor activity
I5776_RS01785	COG3339	Conserved Protein
I5776_RS01790	COG2801	Transposase and inactivated derivatives
I5776_RS01815	COG0586	Pfam SNARE associated Golgi protein
I5776_RS01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5776_RS01845	COG1686	Belongs to the peptidase S11 family
I5776_RS01860	COG1376	ErfK ybiS ycfS ynhG family protein
I5776_RS01885	COG2011	ABC-type metal ion transport system permease component
I5776_RS01900	COG1114	Component of the transport system for branched-chain amino acids
I5776_RS01910	COG1132	(ABC) transporter
I5776_RS01920	COG5002	protein histidine kinase activity
I5776_RS01930	COG0583	DNA-binding transcription factor activity
I5776_RS01935	COG0372	Belongs to the citrate synthase family
I5776_RS01940	COG1876	peptidase activity
I5776_RS01945	COG0640	Transcriptional regulator
I5776_RS01965	COG0726	polysaccharide deacetylase
I5776_RS01970	COG0004	ammonium transporteR
I5776_RS01990	COG1408	metallophosphoesterase
I5776_RS02000	COG3883	PFAM NLP P60 protein
I5776_RS02000	COG0791	NLP P60 protein
I5776_RS02010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5776_RS02025	COG1960	acyl-CoA dehydrogenase activity
I5776_RS02030	COG0183	Belongs to the thiolase family
I5776_RS02040	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS02060	COG0681	Belongs to the peptidase S26 family
I5776_RS02065	COG1737	Transcriptional regulator
I5776_RS02080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5776_RS02090	COG2223	nitrite transmembrane transporter activity
I5776_RS02100	COG4086	secreted protein
I5776_RS02105	COG4166	transmembrane transport
I5776_RS02110	COG0601	transmembrane transport
I5776_RS02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS02120	COG0444	Belongs to the ABC transporter superfamily
I5776_RS02125	COG4608	Belongs to the ABC transporter superfamily
I5776_RS02135	COG2135	peptidase activity
I5776_RS02160	COG2197	response regulator
I5776_RS02180	COG1228	amidohydrolase
I5776_RS02190	COG1263	PTS System
I5776_RS02190	COG2190	(PTS) system
I5776_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS02205	COG2357	RelA SpoT domain protein
I5776_RS02230	COG1960	acyl-CoA dehydrogenase activity
I5776_RS02260	COG2996	Protein conserved in bacteria
I5776_RS02265	COG1164	Oligoendopeptidase f
I5776_RS02270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5776_RS02275	COG0753	catalase activity
I5776_RS02280	COG0626	cystathionine gamma-synthase activity
I5776_RS02285	COG0656	L-ascorbic acid biosynthetic process
I5776_RS02290	COG2814	Major facilitator Superfamily
I5776_RS02295	COG1733	regulation of RNA biosynthetic process
I5776_RS02300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5776_RS02315	COG0477	Major facilitator Superfamily
I5776_RS02320	COG4412	M6 family metalloprotease domain protein
I5776_RS02320	COG1404	Belongs to the peptidase S8 family
I5776_RS02325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5776_RS02350	COG0109	protoheme IX farnesyltransferase activity
I5776_RS02355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5776_RS02360	COG0456	acetyltransferase
I5776_RS02370	COG2226	methyltransferase
I5776_RS02385	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5776_RS02400	COG0475	glutathione-regulated potassium exporter activity
I5776_RS02425	COG0561	phosphatase activity
I5776_RS02430	COG1357	PFAM Pentapeptide repeats (8 copies)
I5776_RS02450	COG1309	transcriptional regulator
I5776_RS02470	COG2207	Transcriptional regulator
I5776_RS02475	COG3711	transcriptional antiterminator
I5776_RS02480	COG1263	PTS System
I5776_RS02480	COG2190	(PTS) system
I5776_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS02485	COG2723	6-phospho-beta-galactosidase activity
I5776_RS02490	COG2723	6-phospho-beta-galactosidase activity
I5776_RS02495	COG2706	6-phosphogluconolactonase activity
I5776_RS02505	COG1309	transcriptional regulator
I5776_RS02510	COG1053	succinate dehydrogenase
I5776_RS02565	COG0785	Cytochrome C biogenesis protein
I5776_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS02580	COG1595	DNA-templated transcription, initiation
I5776_RS02590	COG0772	Belongs to the SEDS family
I5776_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS02615	COG2130	NADP-dependent
I5776_RS02625	COG1063	alcohol dehydrogenase
I5776_RS02630	COG0534	Mate efflux family protein
I5776_RS02635	COG1595	DNA-templated transcription, initiation
I5776_RS02645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5776_RS02645	COG2755	lipolytic protein G-D-S-L family
I5776_RS02655	COG0592	DNA-directed DNA polymerase activity
I5776_RS02660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS02665	COG0346	lactoylglutathione lyase activity
I5776_RS02680	COG1533	DNA photolyase activity
I5776_RS02720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5776_RS02725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5776_RS02740	COG2318	DinB family
I5776_RS02750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS02765	COG0583	DNA-binding transcription factor activity
I5776_RS02805	COG0577	efflux transmembrane transporter activity
I5776_RS02810	COG1136	(ABC) transporter
I5776_RS02820	COG1051	belongs to the nudix hydrolase family
I5776_RS02830	COG1764	response to oxidative stress
I5776_RS02860	COG1131	(ABC) transporter
I5776_RS02870	COG3620	sequence-specific DNA binding
I5776_RS02880	COG0778	Nitroreductase
I5776_RS02890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5776_RS02895	COG0662	Cupin 2, conserved barrel domain protein
I5776_RS02895	COG2207	Transcriptional regulator
I5776_RS02900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5776_RS02915	COG1959	2 iron, 2 sulfur cluster binding
I5776_RS02920	COG2910	NAD(P)H-binding
I5776_RS02925	COG1846	Transcriptional regulator
I5776_RS02930	COG0456	acetyltransferase
I5776_RS02935	COG2808	Putative FMN-binding domain
I5776_RS02940	COG0574	Belongs to the PEP-utilizing enzyme family
I5776_RS02940	COG3848	Pyruvate phosphate dikinase
I5776_RS02965	COG0346	lactoylglutathione lyase activity
I5776_RS02970	COG0477	Major facilitator Superfamily
I5776_RS02975	COG0640	Transcriptional regulator
I5776_RS02980	COG0346	lactoylglutathione lyase activity
I5776_RS03005	COG2720	vancomycin resistance protein
I5776_RS03065	COG2514	catechol 2,3-dioxygenase activity
I5776_RS03080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS03115	COG2078	PFAM AMMECR1 domain protein
I5776_RS03115	COG3885	ferrous iron binding
I5776_RS03120	COG1136	(ABC) transporter
I5776_RS03125	COG0577	efflux transmembrane transporter activity
I5776_RS03130	COG5002	protein histidine kinase activity
I5776_RS03130	COG3850	Histidine kinase
I5776_RS03140	COG1115	amino acid carrier protein
I5776_RS03150	COG1063	alcohol dehydrogenase
I5776_RS03155	COG1983	PspC domain protein
I5776_RS03170	COG1316	TRANSCRIPTIONal
I5776_RS03180	COG0363	glucosamine-6-phosphate deaminase activity
I5776_RS03185	COG2188	Transcriptional regulator
I5776_RS03215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5776_RS03220	COG1984	allophanate hydrolase subunit 2
I5776_RS03225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5776_RS03230	COG2318	DinB family
I5776_RS03235	COG0791	NLP P60 protein
I5776_RS03235	COG1388	LysM domain
I5776_RS03240	COG0768	penicillin binding
I5776_RS03265	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS03265	COG2247	cell wall binding repeat
I5776_RS03315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5776_RS03330	COG0583	DNA-binding transcription factor activity
I5776_RS03335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5776_RS03375	COG2132	Multicopper oxidase
I5776_RS03410	COG3179	chitinase
I5776_RS03430	COG0840	transmembrane signaling receptor activity
I5776_RS03440	COG0840	transmembrane signaling receptor activity
I5776_RS03445	COG1309	transcriptional regulator
I5776_RS03450	COG1404	Belongs to the peptidase S8 family
I5776_RS03465	COG0305	Participates in initiation and elongation during chromosome replication
I5776_RS03485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5776_RS03495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5776_RS03500	COG0747	negative chemotaxis
I5776_RS03505	COG0601	transmembrane transport
I5776_RS03510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS03515	COG0444	Belongs to the ABC transporter superfamily
I5776_RS03520	COG4608	Belongs to the ABC transporter superfamily
I5776_RS03530	COG0673	inositol 2-dehydrogenase activity
I5776_RS03535	COG3623	hexulose-6-phosphate isomerase
I5776_RS03540	COG1940	carbohydrate kinase activity
I5776_RS03560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5776_RS03565	COG0366	Alpha amylase catalytic
I5776_RS03580	COG1175	transmembrane transport
I5776_RS03585	COG0395	ABC-type sugar transport system, permease component
I5776_RS03590	COG5426	von Willebrand factor, type A
I5776_RS03600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5776_RS03605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I5776_RS03610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5776_RS03615	COG0385	Bile acid
I5776_RS03620	COG0697	spore germination
I5776_RS03640	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5776_RS03655	COG3509	depolymerase
I5776_RS03665	COG2362	D-Aminopeptidase
I5776_RS03670	COG0601	transmembrane transport
I5776_RS03675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS03680	COG0444	Belongs to the ABC transporter superfamily
I5776_RS03690	COG4166	transmembrane transport
I5776_RS03700	COG1737	Transcriptional regulator
I5776_RS03705	COG1105	Belongs to the carbohydrate kinase PfkB family
I5776_RS03710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS03710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5776_RS03710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5776_RS03715	COG3684	Belongs to the aldolase LacD family
I5776_RS03720	COG0561	phosphatase activity
I5776_RS03735	COG3631	Ketosteroid isomerase-related protein
I5776_RS03740	COG2188	Transcriptional regulator
I5776_RS03745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5776_RS03755	COG0601	transmembrane transport
I5776_RS03760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS03765	COG0444	Belongs to the ABC transporter superfamily
I5776_RS03770	COG4608	Belongs to the ABC transporter superfamily
I5776_RS03775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5776_RS03780	COG1840	ABC-type Fe3 transport system, periplasmic component
I5776_RS03785	COG3842	ATPase activity
I5776_RS03790	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5776_RS03795	COG1177	transmembrane transport
I5776_RS03810	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5776_RS03820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5776_RS03835	COG2404	hydrolase activity, acting on ester bonds
I5776_RS03850	COG1840	ABC-type Fe3 transport system, periplasmic component
I5776_RS03855	COG3842	ATPase activity
I5776_RS03865	COG0165	Argininosuccinate lyase
I5776_RS03870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5776_RS03895	COG2304	oxidoreductase activity
I5776_RS03900	COG1473	amidohydrolase
I5776_RS03905	COG1288	antiporter activity
I5776_RS03910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5776_RS03915	COG2011	ABC-type metal ion transport system permease component
I5776_RS03920	COG1464	Belongs to the NlpA lipoprotein family
I5776_RS03940	COG3964	amidohydrolase
I5776_RS03960	COG2188	Transcriptional regulator
I5776_RS03965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS03970	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5776_RS03975	COG1486	melibiose metabolic process
I5776_RS03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS04000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5776_RS04005	COG1120	ATPase activity
I5776_RS04010	COG0492	ferredoxin-NADP+ reductase activity
I5776_RS04015	COG1757	Na H antiporter
I5776_RS04025	COG3706	GGDEF domain
I5776_RS04030	COG0596	Alpha beta hydrolase
I5776_RS04040	COG1472	Belongs to the glycosyl hydrolase 3 family
I5776_RS04065	COG1414	Transcriptional regulator
I5776_RS04070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5776_RS04080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I5776_RS04080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I5776_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS04095	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS04115	COG0477	Major facilitator Superfamily
I5776_RS04120	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5776_RS04135	COG2030	dehydratase
I5776_RS04155	COG1960	acyl-CoA dehydrogenase activity
I5776_RS04160	COG1960	acyl-CoA dehydrogenase activity
I5776_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS04175	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I5776_RS04180	COG1301	dicarboxylic acid transport
I5776_RS04185	COG1285	pathogenesis
I5776_RS04205	COG0436	Aminotransferase
I5776_RS04210	COG1522	sequence-specific DNA binding
I5776_RS04215	COG4193	domain, Protein
I5776_RS04220	COG3773	Cell wall hydrolase
I5776_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS04245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5776_RS04250	COG2208	phosphoserine phosphatase activity
I5776_RS04260	COG0765	amino acid transport
I5776_RS04265	COG1126	abc transporter atp-binding protein
I5776_RS04280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I5776_RS04285	COG1263	PTS System
I5776_RS04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS04285	COG2190	(PTS) system
I5776_RS04290	COG2190	(PTS) system
I5776_RS04295	COG0561	phosphatase activity
I5776_RS04305	COG3706	GGDEF domain
I5776_RS04325	COG2723	6-phospho-beta-galactosidase activity
I5776_RS04335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS04345	COG1940	carbohydrate kinase activity
I5776_RS04350	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5776_RS04355	COG1486	melibiose metabolic process
I5776_RS04365	COG1404	Belongs to the peptidase S8 family
I5776_RS04375	COG2333	competence protein COMEC
I5776_RS04375	COG0658	competence protein
I5776_RS04380	COG0606	chelatase, subunit chli
I5776_RS04420	COG5002	protein histidine kinase activity
I5776_RS04425	COG0069	glutamate synthase activity
I5776_RS04430	COG1309	transcriptional regulator
I5776_RS04450	COG1846	Transcriptional regulator
I5776_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS04480	COG1595	DNA-templated transcription, initiation
I5776_RS04495	COG3858	chitin binding
I5776_RS04495	COG1388	LysM domain
I5776_RS04500	COG0840	transmembrane signaling receptor activity
I5776_RS04505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5776_RS04520	COG0753	catalase activity
I5776_RS04525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS04530	COG0456	acetyltransferase
I5776_RS04540	COG0406	alpha-ribazole phosphatase activity
I5776_RS04545	COG2318	DinB family
I5776_RS04550	COG2323	membrane
I5776_RS04565	COG2318	DinB family
I5776_RS04570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5776_RS04590	COG1131	(ABC) transporter
I5776_RS04600	COG2197	response regulator
I5776_RS04625	COG1404	Belongs to the peptidase S8 family
I5776_RS04630	COG1404	Belongs to the peptidase S8 family
I5776_RS04640	COG0653	protein targeting
I5776_RS04650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5776_RS04655	COG1739	Uncharacterized protein family UPF0029
I5776_RS04660	COG4585	Histidine kinase
I5776_RS04665	COG2197	response regulator
I5776_RS04670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS04670	COG1263	PTS System
I5776_RS04675	COG0366	Alpha amylase catalytic
I5776_RS04680	COG2188	Transcriptional regulator
I5776_RS04690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I5776_RS04695	COG1307	EDD domain protein, DegV family
I5776_RS04700	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5776_RS04705	COG1040	competence protein
I5776_RS04725	COG1256	bacterial-type flagellum assembly
I5776_RS04725	COG4786	Flagellar basal body rod
I5776_RS04730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5776_RS04740	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I5776_RS04745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5776_RS04750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5776_RS04765	COG0110	maltose O-acetyltransferase activity
I5776_RS04795	COG2089	acid synthase
I5776_RS04825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5776_RS04830	COG1516	flagellar protein fliS
I5776_RS04860	COG4720	Psort location CytoplasmicMembrane, score
I5776_RS04875	COG1334	flagellar protein FlaG
I5776_RS04885	COG0840	transmembrane signaling receptor activity
I5776_RS04900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5776_RS04910	COG1522	sequence-specific DNA binding
I5776_RS04920	COG2059	Chromate
I5776_RS04925	COG2059	Chromate
I5776_RS04930	COG0653	protein targeting
I5776_RS04940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS04950	COG2884	Cell division ATP-binding protein ftsE
I5776_RS04955	COG2177	Part of the ABC transporter FtsEX involved in
I5776_RS04960	COG0741	lytic transglycosylase activity
I5776_RS04960	COG1196	nuclear chromosome segregation
I5776_RS04960	COG0739	heme binding
I5776_RS04970	COG0626	cystathionine gamma-synthase activity
I5776_RS04975	COG2873	o-acetylhomoserine
I5776_RS04980	COG0460	homoserine dehydrogenase
I5776_RS04985	COG0586	Pfam SNARE associated Golgi protein
I5776_RS04990	COG0793	Belongs to the peptidase S41A family
I5776_RS04990	COG3409	Peptidoglycan-binding domain 1 protein
I5776_RS04995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5776_RS05015	COG2733	membrane
I5776_RS05050	COG5609	conserved protein (DUF2294)
I5776_RS05060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I5776_RS05065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I5776_RS05075	COG2205	protein histidine kinase activity
I5776_RS05080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5776_RS05085	COG0346	lactoylglutathione lyase activity
I5776_RS05105	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS05115	COG0431	NADPH-dependent FMN reductase
I5776_RS05125	COG0745	RESPONSE REGULATOR receiver
I5776_RS05130	COG5002	protein histidine kinase activity
I5776_RS05135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5776_RS05140	COG0573	inorganic phosphate transmembrane transporter activity
I5776_RS05145	COG0581	inorganic phosphate transmembrane transporter activity
I5776_RS05155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5776_RS05160	COG0704	Plays a role in the regulation of phosphate uptake
I5776_RS05165	COG0640	Transcriptional regulator
I5776_RS05180	COG4897	Protein conserved in bacteria
I5776_RS05190	COG0556	nucleotide-excision repair
I5776_RS05195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5776_RS05205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05220	COG0463	Glycosyl transferase, family 2
I5776_RS05225	COG1215	transferase activity, transferring glycosyl groups
I5776_RS05225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05230	COG4193	domain, Protein
I5776_RS05235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5776_RS05240	COG1215	transferase activity, transferring glycosyl groups
I5776_RS05240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05245	COG1215	transferase activity, transferring glycosyl groups
I5776_RS05250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5776_RS05255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5776_RS05260	COG1682	transport, permease protein
I5776_RS05265	COG1134	teichoic acid transport
I5776_RS05270	COG3595	metallopeptidase activity
I5776_RS05275	COG1950	PFAM Membrane protein of
I5776_RS05280	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS05285	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I5776_RS05295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I5776_RS05305	COG0110	maltose O-acetyltransferase activity
I5776_RS05310	COG0457	Tetratricopeptide repeat
I5776_RS05315	COG0492	ferredoxin-NADP+ reductase activity
I5776_RS05320	COG1051	belongs to the nudix hydrolase family
I5776_RS05325	COG1660	Displays ATPase and GTPase activities
I5776_RS05330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5776_RS05335	COG1481	regulation of sporulation
I5776_RS05340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS05345	COG0740	serine-type endopeptidase activity
I5776_RS05355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5776_RS05370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5776_RS05375	COG0126	phosphoglycerate kinase activity
I5776_RS05385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5776_RS05390	COG0148	phosphopyruvate hydratase activity
I5776_RS05395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5776_RS05400	COG1647	Serine aminopeptidase, S33
I5776_RS05405	COG0557	exoribonuclease II activity
I5776_RS05410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5776_RS05420	COG5609	conserved protein (DUF2294)
I5776_RS05425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5776_RS05430	COG3002	Belongs to the UPF0753 family
I5776_RS05435	COG1011	Hydrolase
I5776_RS05445	COG1309	transcriptional regulator
I5776_RS05450	COG0473	3-isopropylmalate dehydrogenase activity
I5776_RS05460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5776_RS05475	COG0702	epimerase
I5776_RS05480	COG0656	L-ascorbic acid biosynthetic process
I5776_RS05490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS05495	COG0789	Transcriptional regulator
I5776_RS05500	COG1819	glycosyl
I5776_RS05520	COG2608	mercury ion transmembrane transporter activity
I5776_RS05525	COG2217	Heavy metal translocating P-type atpase
I5776_RS05555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5776_RS05570	COG0535	radical SAM domain protein
I5776_RS05585	COG0583	DNA-binding transcription factor activity
I5776_RS05590	COG0590	tRNA wobble adenosine to inosine editing
I5776_RS05595	COG0402	S-adenosylhomocysteine deaminase activity
I5776_RS05600	COG0402	S-adenosylhomocysteine deaminase activity
I5776_RS05610	COG5002	protein histidine kinase activity
I5776_RS05615	COG0745	RESPONSE REGULATOR receiver
I5776_RS05620	COG0666	response to abiotic stimulus
I5776_RS05625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS05625	COG3711	transcriptional antiterminator
I5776_RS05630	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5776_RS05635	COG2723	6-phospho-beta-galactosidase activity
I5776_RS05650	COG2814	Major facilitator Superfamily
I5776_RS05665	COG0604	alcohol dehydrogenase
I5776_RS05665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5776_RS05665	COG3321	synthase
I5776_RS05665	COG4221	oxidoreductase activity
I5776_RS05675	COG2720	vancomycin resistance protein
I5776_RS05765	COG0631	protein serine/threonine phosphatase activity
I5776_RS05770	COG0515	serine threonine protein kinase
I5776_RS05770	COG2815	serine threonine protein kinase
I5776_RS05800	COG1609	Transcriptional regulator
I5776_RS05805	COG0366	Alpha amylase catalytic
I5776_RS05810	COG0366	Alpha amylase catalytic
I5776_RS05830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5776_RS05835	COG3973	AAA domain
I5776_RS05855	COG5577	PFAM Coat F domain
I5776_RS05870	COG1657	PFAM Prenyltransferase squalene oxidase
I5776_RS05880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS05885	COG0772	Belongs to the SEDS family
I5776_RS05920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5776_RS05925	COG0805	protein transport
I5776_RS05930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5776_RS05935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS05940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS05945	COG1120	ATPase activity
I5776_RS05960	COG0247	lactate metabolic process
I5776_RS05965	COG0277	FAD linked oxidase domain protein
I5776_RS05970	COG3835	regulator
I5776_RS05975	COG5577	PFAM Coat F domain
I5776_RS05990	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5776_RS05990	COG1024	Enoyl-CoA hydratase
I5776_RS05995	COG0183	Belongs to the thiolase family
I5776_RS06000	COG1960	acyl-CoA dehydrogenase activity
I5776_RS06010	COG1393	Belongs to the ArsC family
I5776_RS06015	COG0509	glycine decarboxylation via glycine cleavage system
I5776_RS06020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS06030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5776_RS06035	COG2011	ABC-type metal ion transport system permease component
I5776_RS06040	COG1464	Belongs to the NlpA lipoprotein family
I5776_RS06050	COG0396	ATPase activity
I5776_RS06055	COG0719	Fe-S assembly protein
I5776_RS06060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5776_RS06065	COG0822	iron-sulfur transferase activity
I5776_RS06070	COG0719	Fe-S assembly protein
I5776_RS06075	COG1801	Protein of unknown function DUF72
I5776_RS06080	COG0737	Belongs to the 5'-nucleotidase family
I5776_RS06085	COG3377	Domain of unknown function (DUF1805)
I5776_RS06095	COG0739	heme binding
I5776_RS06105	COG4470	Protein conserved in bacteria
I5776_RS06115	COG2445	Protein of unknown function DUF86
I5776_RS06120	COG0647	UMP catabolic process
I5776_RS06125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5776_RS06130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5776_RS06135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5776_RS06140	COG4837	Protein of unknown function (DUF1462)
I5776_RS06145	COG4844	belongs to the
I5776_RS06155	COG0316	Belongs to the HesB IscA family
I5776_RS06165	COG1252	NADH dehydrogenase
I5776_RS06180	COG3584	3D domain protein
I5776_RS06185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5776_RS06200	COG2050	protein possibly involved in aromatic compounds catabolism
I5776_RS06205	COG2814	Major facilitator Superfamily
I5776_RS06215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5776_RS06225	COG2032	superoxide dismutase activity
I5776_RS06230	COG2267	carboxylic ester hydrolase activity
I5776_RS06240	COG1098	S1 RNA binding domain
I5776_RS06245	COG3829	transcription factor binding
I5776_RS06250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5776_RS06255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5776_RS06260	COG2155	Conserved Protein
I5776_RS06275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5776_RS06290	COG2814	Major facilitator Superfamily
I5776_RS06295	COG1285	pathogenesis
I5776_RS06425	COG1169	isochorismate synthase
I5776_RS06430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I5776_RS06435	COG0596	Alpha beta hydrolase
I5776_RS06440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I5776_RS06445	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS06450	COG4948	Mandelate Racemase Muconate Lactonizing
I5776_RS06460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5776_RS06470	COG0783	Belongs to the Dps family
I5776_RS06490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5776_RS06495	COG1116	anion transmembrane transporter activity
I5776_RS06500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5776_RS06505	COG1506	peptidase
I5776_RS06525	COG0367	asparagine synthase
I5776_RS06535	COG2267	carboxylic ester hydrolase activity
I5776_RS06545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5776_RS06560	COG2814	Major facilitator Superfamily
I5776_RS06565	COG0495	leucyl-tRNA aminoacylation
I5776_RS06575	COG3764	Sortase (surface protein transpeptidase)
I5776_RS06580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5776_RS06590	COG2081	HI0933 family
I5776_RS06595	COG2244	polysaccharide biosynthetic process
I5776_RS06600	COG1187	pseudouridine synthase activity
I5776_RS06605	COG1349	DNA-binding transcription factor activity
I5776_RS06610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5776_RS06630	COG0510	thiamine kinase activity
I5776_RS06640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5776_RS06645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS06655	COG1368	sulfuric ester hydrolase activity
I5776_RS06660	COG1363	Peptidase, m42
I5776_RS06665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I5776_RS06670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS06675	COG4848	Belongs to the UPF0354 family
I5776_RS06685	COG1674	ftsk spoiiie
I5776_RS06685	COG1674	ftsk spoiiie
I5776_RS06690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5776_RS06695	COG2309	aminopeptidase activity
I5776_RS06705	COG4980	gas vesicle protein
I5776_RS06710	COG0849	cell division
I5776_RS06715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5776_RS06715	COG1605	Chorismate mutase
I5776_RS06730	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5776_RS06735	COG0517	IMP dehydrogenase activity
I5776_RS06740	COG0454	-acetyltransferase
I5776_RS06745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5776_RS06755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5776_RS06760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5776_RS06765	COG2199	diguanylate cyclase activity
I5776_RS06765	COG2203	Gaf domain
I5776_RS06770	COG1956	GAF domain-containing protein
I5776_RS06775	COG1309	transcriptional regulator
I5776_RS06780	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I5776_RS06785	COG1104	cysteine desulfurase activity
I5776_RS06790	COG0301	tRNA thio-modification
I5776_RS06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5776_RS06805	COG2962	Rard protein
I5776_RS06815	COG2962	Rard protein
I5776_RS06820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5776_RS06825	COG0616	signal peptide processing
I5776_RS06830	COG1714	RDD family
I5776_RS06840	COG3874	Sporulation protein YtfJ
I5776_RS06845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5776_RS06850	COG0827	DNA restriction-modification system
I5776_RS06855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5776_RS06875	COG0006	proline dipeptidase activity
I5776_RS06890	COG4109	DRTGG domain
I5776_RS06900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5776_RS06915	COG0587	DNA-directed DNA polymerase activity
I5776_RS06920	COG0281	malic enzyme
I5776_RS06925	COG1725	Transcriptional regulator
I5776_RS06930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5776_RS06935	COG0825	malonyl-CoA metabolic process
I5776_RS06940	COG0205	6-phosphofructokinase activity
I5776_RS06950	COG0628	permease
I5776_RS06955	COG2707	UPF0756 membrane protein
I5776_RS06960	COG0372	Belongs to the citrate synthase family
I5776_RS06965	COG0538	isocitrate dehydrogenase activity
I5776_RS06970	COG0039	L-malate dehydrogenase activity
I5776_RS06980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5776_RS06980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5776_RS06985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5776_RS06990	COG1971	Probably functions as a manganese efflux pump
I5776_RS06995	COG0237	dephospho-CoA kinase activity
I5776_RS07000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5776_RS07005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5776_RS07010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5776_RS07015	COG3611	Membrane attachment protein
I5776_RS07020	COG1484	DNA-dependent DNA replication
I5776_RS07030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5776_RS07035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I5776_RS07040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5776_RS07045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5776_RS07060	COG1363	Peptidase, m42
I5776_RS07070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5776_RS07080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5776_RS07085	COG0072	phenylalanine-tRNA ligase activity
I5776_RS07085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5776_RS07090	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5776_RS07095	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I5776_RS07100	COG1286	toxin biosynthetic process
I5776_RS07105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5776_RS07105	COG1796	DNA polymerase
I5776_RS07110	COG1193	negative regulation of DNA recombination
I5776_RS07115	COG3766	membrane
I5776_RS07120	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS07125	COG1309	transcriptional regulator
I5776_RS07130	COG1024	Enoyl-CoA hydratase
I5776_RS07135	COG2086	electron transfer activity
I5776_RS07140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5776_RS07145	COG3336	cytochrome c oxidase
I5776_RS07150	COG2217	Heavy metal translocating P-type atpase
I5776_RS07155	COG3118	belongs to the thioredoxin family
I5776_RS07160	COG0322	excinuclease ABC activity
I5776_RS07170	COG1719	4-vinyl reductase, 4VR
I5776_RS07175	COG2009	succinate dehydrogenase
I5776_RS07180	COG1053	succinate dehydrogenase
I5776_RS07185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5776_RS07190	COG0824	Thioesterase
I5776_RS07195	COG2197	response regulator
I5776_RS07200	COG1846	Transcriptional regulator
I5776_RS07205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5776_RS07210	COG5401	PFAM Sporulation and spore germination
I5776_RS07225	COG0622	Phosphoesterase
I5776_RS07240	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5776_RS07250	COG1067	ATP-dependent peptidase activity
I5776_RS07250	COG0470	DNA polymerase III
I5776_RS07255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5776_RS07260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5776_RS07275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5776_RS07280	COG0181	hydroxymethylbilane synthase activity
I5776_RS07290	COG0113	porphobilinogen synthase activity
I5776_RS07295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5776_RS07300	COG1388	LysM domain
I5776_RS07300	COG1388	LysM domain
I5776_RS07305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5776_RS07315	COG0525	valine-tRNA ligase activity
I5776_RS07320	COG0285	dihydrofolate synthase activity
I5776_RS07325	COG2203	Gaf domain
I5776_RS07325	COG2199	diguanylate cyclase activity
I5776_RS07365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5776_RS07375	COG1459	type II secretion system
I5776_RS07385	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5776_RS07420	COG2003	Belongs to the UPF0758 family
I5776_RS07425	COG1077	Cell shape determining protein MreB Mrl
I5776_RS07430	COG1792	Involved in formation and maintenance of cell shape
I5776_RS07435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5776_RS07440	COG0850	regulation of cytokinetic process
I5776_RS07445	COG2894	cell division
I5776_RS07450	COG0739	heme binding
I5776_RS07455	COG1994	Peptidase M50
I5776_RS07460	COG1530	ribonuclease E activity
I5776_RS07465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5776_RS07470	COG2868	ribosomal protein
I5776_RS07475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5776_RS07480	COG3290	protein histidine kinase activity
I5776_RS07485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5776_RS07490	COG4492	Belongs to the UPF0735 family
I5776_RS07495	COG0077	Prephenate dehydratase
I5776_RS07500	COG1827	regulation of RNA biosynthetic process
I5776_RS07505	COG1104	cysteine desulfurase activity
I5776_RS07510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5776_RS07515	COG0157	Belongs to the NadC ModD family
I5776_RS07520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5776_RS07545	COG0632	four-way junction helicase activity
I5776_RS07555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5776_RS07565	COG1862	Preprotein translocase
I5776_RS07575	COG2323	membrane
I5776_RS07580	COG2244	polysaccharide biosynthetic process
I5776_RS07590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5776_RS07590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5776_RS07595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5776_RS07595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5776_RS07600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5776_RS07605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5776_RS07615	COG4991	sh3 domain protein
I5776_RS07615	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS07615	COG3103	Sh3 type 3 domain protein
I5776_RS07625	COG0124	histidyl-tRNA synthetase
I5776_RS07630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5776_RS07640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5776_RS07650	COG1725	Transcriptional regulator
I5776_RS07655	COG1131	(ABC) transporter
I5776_RS07660	COG1131	(ABC) transporter
I5776_RS07665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5776_RS07670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5776_RS07675	COG2364	Membrane
I5776_RS07680	COG1959	2 iron, 2 sulfur cluster binding
I5776_RS07685	COG1104	cysteine desulfurase activity
I5776_RS07690	COG0482	sulfurtransferase activity
I5776_RS07700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5776_RS07720	COG0628	permease
I5776_RS07730	COG4472	Bacterial protein of unknown function (DUF965)
I5776_RS07735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5776_RS07740	COG3906	Belongs to the UPF0473 family
I5776_RS07745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5776_RS07750	COG4122	O-methyltransferase activity
I5776_RS07755	COG0572	uridine kinase
I5776_RS07760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5776_RS07765	COG0768	penicillin binding
I5776_RS07775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5776_RS07785	COG1566	PFAM secretion protein HlyD family protein
I5776_RS07790	COG2814	Major facilitator Superfamily
I5776_RS07810	COG1183	phosphatidylcholine synthase activity
I5776_RS07815	COG0688	phosphatidylethanolamine metabolic process
I5776_RS07825	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I5776_RS07830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5776_RS07840	COG1534	Rna-binding protein
I5776_RS07845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5776_RS07850	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5776_RS07855	COG0799	negative regulation of ribosome biogenesis
I5776_RS07860	COG2226	methyltransferase
I5776_RS07865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5776_RS07870	COG1596	polysaccharide export
I5776_RS07870	COG1555	photosystem II stabilization
I5776_RS07875	COG2131	deaminase
I5776_RS07880	COG2333	competence protein COMEC
I5776_RS07880	COG0658	competence protein
I5776_RS07890	COG1466	dna polymerase III delta subunit
I5776_RS07895	COG0268	Binds directly to 16S ribosomal RNA
I5776_RS07905	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5776_RS07915	COG0481	GTPase activity
I5776_RS07920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5776_RS07925	COG1420	regulation of RNA biosynthetic process
I5776_RS07930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5776_RS07935	COG0443	Heat shock 70 kDa protein
I5776_RS07945	COG2264	protein methyltransferase activity
I5776_RS07950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5776_RS07955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5776_RS07960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5776_RS07965	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5776_RS07970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5776_RS07975	COG1610	YqeY-like protein
I5776_RS07980	COG1030	water channel activity
I5776_RS07985	COG4864	UPF0365 protein
I5776_RS08005	COG1702	phosphate starvation-inducible protein PhoH
I5776_RS08010	COG1480	7TM receptor with intracellular HD hydrolase
I5776_RS08020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5776_RS08025	COG0295	cytidine deaminase activity
I5776_RS08030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5776_RS08040	COG1381	Involved in DNA repair and RecF pathway recombination
I5776_RS08045	COG0517	IMP dehydrogenase activity
I5776_RS08055	COG1671	Belongs to the UPF0178 family
I5776_RS08060	COG0358	DNA primase activity
I5776_RS08065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5776_RS08075	COG1960	acyl-CoA dehydrogenase activity
I5776_RS08080	COG2010	Cytochrome c
I5776_RS08085	COG2384	SAM-dependent methyltransferase
I5776_RS08090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5776_RS08095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5776_RS08110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I5776_RS08120	COG0735	belongs to the Fur family
I5776_RS08125	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I5776_RS08130	COG4709	membrane
I5776_RS08135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5776_RS08145	COG5521	maltodextrose utilization protein MalA
I5776_RS08150	COG2839	Protein conserved in bacteria
I5776_RS08155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5776_RS08160	COG0477	Major facilitator Superfamily
I5776_RS08165	COG0768	penicillin binding
I5776_RS08170	COG0768	penicillin binding
I5776_RS08185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5776_RS08190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5776_RS08195	COG0457	Tetratricopeptide repeat
I5776_RS08195	COG0705	Rhomboid family
I5776_RS08205	COG4483	Protein conserved in bacteria
I5776_RS08210	COG1940	carbohydrate kinase activity
I5776_RS08215	COG1368	sulfuric ester hydrolase activity
I5776_RS08230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS08240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5776_RS08245	COG1459	type II secretion system
I5776_RS08250	COG4537	Required for transformation and DNA binding
I5776_RS08255	COG4970	Tfp pilus assembly protein FimT
I5776_RS08285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5776_RS08290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5776_RS08295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5776_RS08300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5776_RS08305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5776_RS08335	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5776_RS08345	COG3872	metal-dependent enzyme
I5776_RS08355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5776_RS08360	COG0006	proline dipeptidase activity
I5776_RS08365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5776_RS08370	COG3854	ATPases associated with a variety of cellular activities
I5776_RS08410	COG0511	ligase activity, forming carbon-carbon bonds
I5776_RS08415	COG0439	Biotin carboxylase
I5776_RS08420	COG1302	Protein conserved in bacteria
I5776_RS08435	COG1722	exodeoxyribonuclease VII activity
I5776_RS08445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5776_RS08450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I5776_RS08455	COG1438	arginine binding
I5776_RS08460	COG0497	DNA recombination
I5776_RS08465	COG0750	zinc metalloprotease
I5776_RS08480	COG0584	glycerophosphoryl diester phosphodiesterase
I5776_RS08490	COG3290	protein histidine kinase activity
I5776_RS08490	COG3829	transcription factor binding
I5776_RS08495	COG0280	phosphate acetyltransferase
I5776_RS08510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5776_RS08515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5776_RS08520	COG0022	dehydrogenase e1 component
I5776_RS08525	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5776_RS08530	COG0598	Magnesium transport protein CorA
I5776_RS08540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5776_RS08545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5776_RS08545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5776_RS08550	COG1703	isobutyryl-CoA mutase activity
I5776_RS08560	COG4129	membrane
I5776_RS08575	COG0346	lactoylglutathione lyase activity
I5776_RS08580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5776_RS08585	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5776_RS08590	COG0784	Response regulator, receiver
I5776_RS08590	COG0835	chemotaxis
I5776_RS08600	COG5506	Protein of unknown function (DUF1694)
I5776_RS08605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5776_RS08610	COG1234	tRNA 3'-trailer cleavage
I5776_RS08615	COG1902	pentaerythritol trinitrate reductase activity
I5776_RS08620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5776_RS08625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS08630	COG0300	oxidoreductase activity
I5776_RS08635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5776_RS08655	COG3858	chitin binding
I5776_RS08655	COG1388	LysM domain
I5776_RS08660	COG1073	alpha beta
I5776_RS08665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5776_RS08670	COG3853	Toxic anion resistance protein (TelA)
I5776_RS08675	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I5776_RS08685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5776_RS08690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5776_RS08700	COG3764	Sortase (surface protein transpeptidase)
I5776_RS08710	COG1396	sequence-specific DNA binding
I5776_RS08740	COG0398	Pfam SNARE associated Golgi protein
I5776_RS08765	COG0667	Aldo Keto reductase
I5776_RS08780	COG1379	DNA repair
I5776_RS08795	COG1300	Membrane
I5776_RS08800	COG0735	belongs to the Fur family
I5776_RS08810	COG4974	Belongs to the 'phage' integrase family
I5776_RS08830	COG1686	Belongs to the peptidase S11 family
I5776_RS08865	COG0697	spore germination
I5776_RS08880	COG1547	Domain of unknown function (DUF309)
I5776_RS08890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5776_RS08895	COG1686	Belongs to the peptidase S11 family
I5776_RS08900	COG2715	membrane protein required for spore maturation
I5776_RS08905	COG0700	Nucleoside recognition
I5776_RS08910	COG1187	pseudouridine synthase activity
I5776_RS08915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS08920	COG1333	cytochrome c biogenesis protein
I5776_RS08925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5776_RS08930	COG0745	RESPONSE REGULATOR receiver
I5776_RS08935	COG5002	protein histidine kinase activity
I5776_RS08940	COG0739	heme binding
I5776_RS08945	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I5776_RS08950	COG1141	Ferredoxin
I5776_RS08955	COG4955	Helix-turn-helix domain
I5776_RS08960	COG0514	ATP-dependent DNA helicase (RecQ)
I5776_RS08965	COG1266	CAAX protease self-immunity
I5776_RS08980	COG3546	catalase activity
I5776_RS09005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5776_RS09010	COG0492	ferredoxin-NADP+ reductase activity
I5776_RS09015	COG0252	asparaginase activity
I5776_RS09020	COG2339	peptidase activity
I5776_RS09025	COG3773	Cell wall hydrolase
I5776_RS09025	COG3409	Peptidoglycan-binding domain 1 protein
I5776_RS09030	COG2959	enzyme of heme biosynthesis
I5776_RS09055	COG0539	negative regulation of cytoplasmic translation
I5776_RS09070	COG1160	GTP binding
I5776_RS09075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5776_RS09090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5776_RS09095	COG0776	regulation of translation
I5776_RS09100	COG0302	gtp cyclohydrolase
I5776_RS09105	COG0142	geranyltranstransferase activity
I5776_RS09110	COG2226	methyltransferase
I5776_RS09115	COG0142	geranyltranstransferase activity
I5776_RS09120	COG0105	UTP biosynthetic process
I5776_RS09125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5776_RS09130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5776_RS09140	COG4401	Chorismate mutase type I
I5776_RS09145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5776_RS09150	COG0287	Prephenate dehydrogenase
I5776_RS09155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5776_RS09165	COG0457	Tetratricopeptide repeat
I5776_RS09170	COG5582	Belongs to the UPF0302 family
I5776_RS09185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5776_RS09195	COG4347	Protein of unknown function (DUF1405)
I5776_RS09205	COG2738	Putative neutral zinc metallopeptidase
I5776_RS09210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS09215	COG1694	Mazg nucleotide pyrophosphohydrolase
I5776_RS09220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5776_RS09225	COG1803	Methylglyoxal synthase
I5776_RS09230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5776_RS09235	COG0438	transferase activity, transferring glycosyl groups
I5776_RS09245	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I5776_RS09245	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I5776_RS09255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5776_RS09260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I5776_RS09265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5776_RS09265	COG1199	ATP-dependent helicase activity
I5776_RS09280	COG0436	Aminotransferase
I5776_RS09285	COG3935	DnaD domain protein
I5776_RS09290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5776_RS09295	COG4499	WXG100 protein secretion system (Wss), protein YukC
I5776_RS09295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5776_RS09320	COG0071	Belongs to the small heat shock protein (HSP20) family
I5776_RS09325	COG1111	helicase
I5776_RS09325	COG1205	dead DEAH box helicase
I5776_RS09330	COG3359	exonuclease
I5776_RS09365	COG1199	ATP-dependent helicase activity
I5776_RS09370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5776_RS09375	COG0697	spore germination
I5776_RS09380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5776_RS09385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5776_RS09400	COG2233	PERMEase
I5776_RS09410	COG3424	synthase
I5776_RS09415	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5776_RS09420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5776_RS09430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5776_RS09450	COG0328	RNA-DNA hybrid ribonuclease activity
I5776_RS09455	COG0328	RNA-DNA hybrid ribonuclease activity
I5776_RS09470	COG1321	iron dependent repressor
I5776_RS09500	COG1418	mRNA catabolic process
I5776_RS09505	COG0488	(ABC) transporter
I5776_RS09510	COG1413	lyase activity
I5776_RS09520	COG2521	methyltransferase
I5776_RS09520	COG2136	Putative SAM-dependent methyltransferase
I5776_RS09535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5776_RS09540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5776_RS09550	COG2755	lipolytic protein G-D-S-L family
I5776_RS09570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5776_RS09575	COG0840	transmembrane signaling receptor activity
I5776_RS09580	COG4479	Belongs to the UPF0346 family
I5776_RS09610	COG1876	peptidase activity
I5776_RS09615	COG3409	Peptidoglycan-binding domain 1 protein
I5776_RS09615	COG0793	Belongs to the peptidase S41A family
I5776_RS09620	COG1846	Transcriptional regulator
I5776_RS09635	COG2340	Cysteine-rich secretory protein family
I5776_RS09650	COG0586	Pfam SNARE associated Golgi protein
I5776_RS09665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I5776_RS09670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5776_RS09675	COG1793	dna ligase
I5776_RS09675	COG3285	dna ligase
I5776_RS09680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I5776_RS09685	COG0671	phosphoesterase, PA-phosphatase related
I5776_RS09695	COG1278	Cold shock
I5776_RS09700	COG1368	sulfuric ester hydrolase activity
I5776_RS09715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5776_RS09720	COG0596	Alpha beta hydrolase
I5776_RS09730	COG4145	pantothenate transmembrane transporter activity
I5776_RS09735	COG2814	Major facilitator Superfamily
I5776_RS09740	COG2258	MOSC domain
I5776_RS09745	COG0444	Belongs to the ABC transporter superfamily
I5776_RS09750	COG4608	Belongs to the ABC transporter superfamily
I5776_RS09755	COG0747	negative chemotaxis
I5776_RS09760	COG0601	transmembrane transport
I5776_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS09770	COG0745	RESPONSE REGULATOR receiver
I5776_RS09775	COG5002	protein histidine kinase activity
I5776_RS09785	COG0567	Dehydrogenase, E1 component
I5776_RS09790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5776_RS09800	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS09815	COG1131	(ABC) transporter
I5776_RS09825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5776_RS09830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I5776_RS09835	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I5776_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS09855	COG0714	Associated with various cellular activities
I5776_RS09860	COG4548	von Willebrand factor, type A
I5776_RS09870	COG1686	Belongs to the peptidase S11 family
I5776_RS09875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5776_RS09885	COG0303	'Molybdopterin
I5776_RS09890	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5776_RS09910	COG2223	nitrite transmembrane transporter activity
I5776_RS09920	COG1054	Belongs to the UPF0176 family
I5776_RS09925	COG0392	lysyltransferase activity
I5776_RS09925	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I5776_RS09930	COG1164	Oligoendopeptidase f
I5776_RS09945	COG2323	membrane
I5776_RS09950	COG2368	4-hydroxyphenylacetate
I5776_RS09955	COG0488	(ABC) transporter
I5776_RS09965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5776_RS09965	COG0723	plastoquinol--plastocyanin reductase activity
I5776_RS09970	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I5776_RS09985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5776_RS09995	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5776_RS10000	COG1121	(ABC) transporter
I5776_RS10005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5776_RS10005	COG1321	iron dependent repressor
I5776_RS10010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5776_RS10025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I5776_RS10035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5776_RS10040	COG0131	Imidazoleglycerol-phosphate dehydratase
I5776_RS10045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5776_RS10060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5776_RS10060	COG0140	phosphoribosyl-ATP diphosphatase activity
I5776_RS10080	COG0697	spore germination
I5776_RS10100	COG0242	peptide deformylase activity
I5776_RS10110	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5776_RS10115	COG1121	(ABC) transporter
I5776_RS10120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5776_RS10125	COG1278	Cold shock
I5776_RS10135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5776_RS10140	COG1193	negative regulation of DNA recombination
I5776_RS10150	COG1725	Transcriptional regulator
I5776_RS10175	COG3773	Cell wall hydrolase
I5776_RS10180	COG5577	PFAM Coat F domain
I5776_RS10200	COG0708	Exodeoxyribonuclease III
I5776_RS10225	COG0488	(ABC) transporter
I5776_RS10250	COG1595	DNA-templated transcription, initiation
I5776_RS10280	COG0726	polysaccharide deacetylase
I5776_RS10290	COG3852	Histidine kinase
I5776_RS10320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5776_RS10325	COG0187	DNA topoisomerase II activity
I5776_RS10330	COG1832	CoA-binding protein
I5776_RS10335	COG2233	PERMEase
I5776_RS10340	COG3858	chitin binding
I5776_RS10345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5776_RS10350	COG2843	Capsule synthesis protein
I5776_RS10355	COG4841	protein insertion into membrane
I5776_RS10365	COG0824	Thioesterase
I5776_RS10385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS10390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5776_RS10400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS10425	COG0739	heme binding
I5776_RS10430	COG2427	Protein of unknown function (DUF1641)
I5776_RS10435	COG1510	regulation of RNA biosynthetic process
I5776_RS10440	COG4175	Glycine betaine
I5776_RS10440	COG0517	IMP dehydrogenase activity
I5776_RS10445	COG4176	ABC-type proline glycine betaine transport system permease component
I5776_RS10450	COG2113	Glycine betaine
I5776_RS10460	COG0842	Transport permease protein
I5776_RS10465	COG1511	domain protein
I5776_RS10465	COG0842	Transport permease protein
I5776_RS10470	COG1131	(ABC) transporter
I5776_RS10475	COG2197	response regulator
I5776_RS10480	COG4585	Histidine kinase
I5776_RS10485	COG3314	Sporulation integral membrane protein YlbJ
I5776_RS10490	COG0010	Belongs to the arginase family
I5776_RS10495	COG1228	amidohydrolase
I5776_RS10500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5776_RS10505	COG3162	membrane
I5776_RS10510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5776_RS10515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5776_RS10515	COG2207	Transcriptional regulator
I5776_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS10530	COG2030	dehydratase
I5776_RS10535	COG1914	H( )-stimulated, divalent metal cation uptake system
I5776_RS10540	COG1473	amidohydrolase
I5776_RS10550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5776_RS10565	COG2323	membrane
I5776_RS10575	COG1126	abc transporter atp-binding protein
I5776_RS10580	COG0765	amino acid transport
I5776_RS10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS10605	COG0352	thiamine-phosphate diphosphorylase activity
I5776_RS10610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I5776_RS10615	COG0351	phosphomethylpyrimidine kinase
I5776_RS10615	COG0352	thiamine-phosphate diphosphorylase activity
I5776_RS10630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS10650	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I5776_RS10655	COG0709	Synthesizes selenophosphate from selenide and ATP
I5776_RS10660	COG0701	Predicted permease
I5776_RS10680	COG0477	Major facilitator Superfamily
I5776_RS10685	COG0561	phosphatase activity
I5776_RS10690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5776_RS10695	COG0733	neurotransmitter:sodium symporter activity
I5776_RS10705	COG0726	polysaccharide deacetylase
I5776_RS10725	COG3239	Fatty acid desaturase
I5776_RS10735	COG0322	excinuclease ABC activity
I5776_RS10740	COG1879	ABC-type sugar transport system periplasmic component
I5776_RS10745	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5776_RS10750	COG1129	ABC transporter
I5776_RS10755	COG1869	D-ribose catabolic process
I5776_RS10760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5776_RS10765	COG1609	Transcriptional regulator
I5776_RS10785	COG1064	alcohol dehydrogenase
I5776_RS10795	COG0789	Transcriptional regulator
I5776_RS10800	COG2814	Major facilitator Superfamily
I5776_RS10835	COG0716	FMN binding
I5776_RS10845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5776_RS10850	COG0436	Aminotransferase
I5776_RS10885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS10900	COG0656	L-ascorbic acid biosynthetic process
I5776_RS10910	COG0673	inositol 2-dehydrogenase activity
I5776_RS10915	COG0673	inositol 2-dehydrogenase activity
I5776_RS10935	COG1653	transport
I5776_RS10940	COG1609	Transcriptional regulator
I5776_RS10950	COG1294	oxidase, subunit
I5776_RS10955	COG1271	oxidase subunit
I5776_RS10960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5776_RS10965	COG0778	Nitroreductase
I5776_RS10975	COG0386	Belongs to the glutathione peroxidase family
I5776_RS11010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5776_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS11040	COG1733	regulation of RNA biosynthetic process
I5776_RS11080	COG1309	transcriptional regulator
I5776_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS11105	COG1694	Mazg nucleotide pyrophosphohydrolase
I5776_RS11130	COG1309	transcriptional regulator
I5776_RS11135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS11140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5776_RS11150	COG1309	transcriptional regulator
I5776_RS11170	COG0697	spore germination
I5776_RS11180	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5776_RS11200	COG0768	penicillin binding
I5776_RS11205	COG0768	penicillin binding
I5776_RS11220	COG2814	Major facilitator Superfamily
I5776_RS11240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS11365	COG1473	amidohydrolase
I5776_RS11370	COG1473	amidohydrolase
I5776_RS11375	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5776_RS11390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I5776_RS11410	COG3012	SEC-C Motif Domain Protein
I5776_RS11410	COG1405	negative regulation of cell septum assembly
I5776_RS11415	COG2814	Major facilitator Superfamily
I5776_RS11420	COG0693	protein deglycase activity
I5776_RS11440	COG0640	Transcriptional regulator
I5776_RS11445	COG5658	integral membrane protein
I5776_RS11460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5776_RS11480	COG3961	Belongs to the TPP enzyme family
I5776_RS11490	COG0640	Transcriptional regulator
I5776_RS11505	COG0247	lactate metabolic process
I5776_RS11510	COG0277	FAD linked oxidase domain protein
I5776_RS11515	COG0579	oxidoreductase
I5776_RS11530	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5776_RS11535	COG3842	ATPase activity
I5776_RS11550	COG2204	response regulator
I5776_RS11555	COG3852	Histidine kinase
I5776_RS11560	COG3663	DNA glycosylase
I5776_RS11580	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5776_RS11590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS11610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5776_RS11625	COG0006	proline dipeptidase activity
I5776_RS11630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5776_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS11645	COG3655	Transcriptional regulator
I5776_RS11650	COG1272	protein, Hemolysin III
I5776_RS11655	COG1278	Cold shock
I5776_RS11680	COG1404	Belongs to the peptidase S8 family
I5776_RS11700	COG1126	abc transporter atp-binding protein
I5776_RS11705	COG0765	amino acid transport
I5776_RS11715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS11740	COG2318	DinB family
I5776_RS11745	COG1051	belongs to the nudix hydrolase family
I5776_RS11765	COG0431	NADPH-dependent FMN reductase
I5776_RS11775	COG1732	Glycine betaine
I5776_RS11780	COG1174	glycine betaine transport
I5776_RS11785	COG0517	IMP dehydrogenase activity
I5776_RS11785	COG1125	glycine betaine transport
I5776_RS11790	COG1510	regulation of RNA biosynthetic process
I5776_RS11795	COG3011	Protein conserved in bacteria
I5776_RS11800	COG2814	Major facilitator Superfamily
I5776_RS11805	COG0583	DNA-binding transcription factor activity
I5776_RS11810	COG3739	integral membrane protein
I5776_RS11815	COG3655	Transcriptional regulator
I5776_RS11830	COG1119	ATPase activity
I5776_RS11845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I5776_RS11855	COG1959	2 iron, 2 sulfur cluster binding
I5776_RS11870	COG1027	Aspartate ammonia-lyase
I5776_RS11905	COG2066	Belongs to the glutaminase family
I5776_RS11915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5776_RS11920	COG1074	ATP-dependent DNA helicase activity
I5776_RS11940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5776_RS11945	COG0512	Glutamine amidotransferase of anthranilate synthase
I5776_RS11960	COG1266	CAAX protease self-immunity
I5776_RS11975	COG0165	Argininosuccinate lyase
I5776_RS11980	COG0137	argininosuccinate synthase activity
I5776_RS11985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5776_RS11990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5776_RS11995	COG0505	Belongs to the CarA family
I5776_RS12000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5776_RS12005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5776_RS12010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5776_RS12015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5776_RS12020	COG5001	Diguanylate cyclase
I5776_RS12020	COG3300	MHYT domain
I5776_RS12025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5776_RS12030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5776_RS12040	COG2226	methyltransferase
I5776_RS12045	COG0601	transmembrane transport
I5776_RS12065	COG0419	ATPase involved in DNA repair
I5776_RS12070	COG0420	3'-5' exonuclease activity
I5776_RS12090	COG4846	Membrane protein involved in cytochrome C biogenesis
I5776_RS12095	COG2201	protein-glutamate methylesterase activity
I5776_RS12100	COG0785	Cytochrome C biogenesis protein
I5776_RS12110	COG1132	(ABC) transporter
I5776_RS12115	COG1132	(ABC) transporter
I5776_RS12140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5776_RS12150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5776_RS12155	COG3409	Peptidoglycan-binding domain 1 protein
I5776_RS12155	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5776_RS12160	COG0174	glutamine synthetase
I5776_RS12165	COG0789	Transcriptional regulator
I5776_RS12170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I5776_RS12175	COG2860	membrane
I5776_RS12180	COG0464	growth
I5776_RS12190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5776_RS12215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS12225	COG2076	Multidrug Resistance protein
I5776_RS12230	COG2076	Multidrug Resistance protein
I5776_RS12255	COG0438	transferase activity, transferring glycosyl groups
I5776_RS12280	COG4464	protein tyrosine phosphatase activity
I5776_RS12285	COG0489	protein tyrosine kinase activity
I5776_RS12290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5776_RS12295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5776_RS12300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5776_RS12315	COG4550	Control of competence regulator ComK, YlbF/YmcA
I5776_RS12320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5776_RS12325	COG2359	stage V sporulation protein S
I5776_RS12330	COG1692	metallophosphoesterase
I5776_RS12340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I5776_RS12345	COG1546	Belongs to the CinA family
I5776_RS12345	COG1058	Belongs to the CinA family
I5776_RS12350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5776_RS12355	COG1426	Protein conserved in bacteria
I5776_RS12370	COG0300	oxidoreductase activity
I5776_RS12375	COG0612	Peptidase, M16
I5776_RS12380	COG0612	Peptidase, M16
I5776_RS12385	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5776_RS12390	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5776_RS12395	COG3845	ABC transporter
I5776_RS12400	COG1744	ABC transporter substrate-binding protein PnrA-like
I5776_RS12405	COG2188	Transcriptional regulator
I5776_RS12410	COG4980	gas vesicle protein
I5776_RS12410	COG1674	ftsk spoiiie
I5776_RS12420	COG0740	serine-type endopeptidase activity
I5776_RS12425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5776_RS12445	COG0527	aspartate kinase activity
I5776_RS12450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5776_RS12455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5776_RS12460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5776_RS12465	COG1873	PFAM PRC-barrel domain
I5776_RS12470	COG0612	Peptidase, M16
I5776_RS12475	COG0726	polysaccharide deacetylase
I5776_RS12480	COG1185	polyribonucleotide nucleotidyltransferase activity
I5776_RS12485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5776_RS12490	COG0196	riboflavin kinase activity
I5776_RS12495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5776_RS12500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5776_RS12505	COG1550	Protein conserved in bacteria
I5776_RS12510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5776_RS12515	COG1358	cellular component organization or biogenesis
I5776_RS12520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5776_RS12525	COG0195	Participates in both transcription termination and antitermination
I5776_RS12530	COG0779	Required for maturation of 30S ribosomal subunits
I5776_RS12535	COG2176	DNA-directed DNA polymerase activity
I5776_RS12540	COG0750	zinc metalloprotease
I5776_RS12545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5776_RS12550	COG4589	Belongs to the CDS family
I5776_RS12560	COG0233	cytoplasmic translational termination
I5776_RS12575	COG0052	Belongs to the universal ribosomal protein uS2 family
I5776_RS12590	COG1191	sigma factor activity
I5776_RS12595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I5776_RS12600	COG1776	CheC inhibitor of MCP methylation
I5776_RS12605	COG0835	chemotaxis
I5776_RS12610	COG2198	Histidine kinase
I5776_RS12610	COG0643	Histidine kinase
I5776_RS12615	COG2201	protein-glutamate methylesterase activity
I5776_RS12620	COG0455	bacterial-type flagellum organization
I5776_RS12625	COG1419	protein localization to endoplasmic reticulum
I5776_RS12630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5776_RS12635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5776_RS12640	COG1684	flagellar biosynthetic protein fliR
I5776_RS12645	COG1987	bacterial-type flagellum assembly
I5776_RS12650	COG1338	Plays a role in the flagellum-specific transport system
I5776_RS12655	COG3190	flagellar
I5776_RS12660	COG2201	protein-glutamate methylesterase activity
I5776_RS12665	COG1776	CheC inhibitor of MCP methylation
I5776_RS12665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5776_RS12670	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5776_RS12675	COG1580	Controls the rotational direction of flagella during chemotaxis
I5776_RS12680	COG1582	Flagellar protein (FlbD)
I5776_RS12695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I5776_RS12710	COG2882	bacterial-type flagellum organization
I5776_RS12715	COG1157	protein secretion by the type III secretion system
I5776_RS12720	COG1317	bacterial-type flagellum organization
I5776_RS12725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5776_RS12730	COG1766	The M ring may be actively involved in energy transduction
I5776_RS12735	COG1677	Flagellar hook-basal body complex protein FliE
I5776_RS12740	COG1558	bacterial-type flagellum-dependent cell motility
I5776_RS12745	COG1815	bacterial-type flagellum-dependent cell motility
I5776_RS12750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5776_RS12755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5776_RS12765	COG4974	Belongs to the 'phage' integrase family
I5776_RS12770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5776_RS12775	COG0758	DNA mediated transformation
I5776_RS12780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5776_RS12785	COG0045	succinate-CoA ligase (ADP-forming) activity
I5776_RS12790	COG2257	FlhB HrpN YscU SpaS Family
I5776_RS12800	COG1657	PFAM Prenyltransferase squalene oxidase
I5776_RS12805	COG1979	alcohol dehydrogenase
I5776_RS12810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5776_RS12810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5776_RS12810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS12815	COG1105	Belongs to the carbohydrate kinase PfkB family
I5776_RS12820	COG1349	DNA-binding transcription factor activity
I5776_RS12845	COG0336	Belongs to the RNA methyltransferase TrmD family
I5776_RS12850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5776_RS12860	COG1837	Belongs to the UPF0109 family
I5776_RS12865	COG0228	four-way junction DNA binding
I5776_RS12870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5776_RS12875	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I5776_RS12880	COG0552	protein localization to endoplasmic reticulum
I5776_RS12885	COG1196	nuclear chromosome segregation
I5776_RS12890	COG0571	ribonuclease III activity
I5776_RS12895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5776_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS12905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5776_RS12915	COG1349	DNA-binding transcription factor activity
I5776_RS12920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5776_RS12925	COG1760	l-serine dehydratase
I5776_RS12930	COG1760	l-serine dehydratase
I5776_RS12935	COG1461	Dihydroxyacetone kinase
I5776_RS12940	COG1302	Protein conserved in bacteria
I5776_RS12945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5776_RS12955	COG1564	THIamine pyrophosphokinase
I5776_RS12960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5776_RS12965	COG1162	GTPase activity
I5776_RS12970	COG2815	serine threonine protein kinase
I5776_RS12970	COG0515	serine threonine protein kinase
I5776_RS12975	COG0631	protein serine/threonine phosphatase activity
I5776_RS12980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5776_RS12980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5776_RS12985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5776_RS12990	COG0242	peptide deformylase activity
I5776_RS12995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5776_RS13000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5776_RS13010	COG0194	GDP metabolic process
I5776_RS13020	COG1561	YicC-like family, N-terminal region
I5776_RS13025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I5776_RS13045	COG0167	dihydroorotate dehydrogenase activity
I5776_RS13050	COG0543	2 iron, 2 sulfur cluster binding
I5776_RS13055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5776_RS13065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5776_RS13070	COG0540	Belongs to the ATCase OTCase family
I5776_RS13075	COG2233	PERMEase
I5776_RS13080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5776_RS13085	COG0564	pseudouridine synthase activity
I5776_RS13090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5776_RS13100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5776_RS13105	COG3599	regulation of cell shape
I5776_RS13110	COG2302	S4 RNA-binding domain
I5776_RS13115	COG0762	integral membrane protein
I5776_RS13120	COG1799	cell septum assembly
I5776_RS13125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5776_RS13130	COG1496	oxidoreductase activity
I5776_RS13135	COG1873	PFAM PRC-barrel domain
I5776_RS13140	COG1191	sigma factor activity
I5776_RS13145	COG1191	sigma factor activity
I5776_RS13155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5776_RS13160	COG0849	cell division
I5776_RS13165	COG3856	small basic protein
I5776_RS13170	COG3879	Bacterial protein of unknown function (DUF881)
I5776_RS13175	COG3879	Bacterial protein of unknown function (DUF881)
I5776_RS13180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5776_RS13185	COG0772	Belongs to the SEDS family
I5776_RS13195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5776_RS13205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5776_RS13210	COG0768	penicillin binding
I5776_RS13220	COG4839	cell division protein FtsL
I5776_RS13225	COG0275	rRNA processing
I5776_RS13230	COG2001	Belongs to the MraZ family
I5776_RS13235	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I5776_RS13245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5776_RS13250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5776_RS13255	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5776_RS13260	COG0439	Biotin carboxylase
I5776_RS13265	COG0454	-acetyltransferase
I5776_RS13275	COG1024	Enoyl-CoA hydratase
I5776_RS13280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5776_RS13285	COG1399	metal-binding, possibly nucleic acid-binding protein
I5776_RS13290	COG1323	Belongs to the UPF0348 family
I5776_RS13295	COG3480	Lon protease (S16) C-terminal proteolytic domain
I5776_RS13300	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5776_RS13305	COG3314	Sporulation integral membrane protein YlbJ
I5776_RS13310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5776_RS13315	COG0742	ribosomal rna small subunit methyltransferase
I5776_RS13335	COG4471	UPF0298 protein
I5776_RS13340	COG3679	Belongs to the UPF0342 family
I5776_RS13360	COG2340	Cysteine-rich secretory protein family
I5776_RS13375	COG3336	cytochrome c oxidase
I5776_RS13395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5776_RS13395	COG2010	Cytochrome c
I5776_RS13400	COG0109	protoheme IX farnesyltransferase activity
I5776_RS13405	COG1612	heme a metabolic process
I5776_RS13410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5776_RS13415	COG0772	Belongs to the SEDS family
I5776_RS13430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5776_RS13440	COG4896	Protein conserved in bacteria
I5776_RS13450	COG1217	gtp-binding protein TYPA
I5776_RS13460	COG0483	inositol monophosphate 1-phosphatase activity
I5776_RS13470	COG4493	Belongs to the UPF0637 family
I5776_RS13475	COG4476	Belongs to the UPF0223 family
I5776_RS13485	COG1982	Orn Lys Arg decarboxylase major
I5776_RS13510	COG0022	dehydrogenase e1 component
I5776_RS13525	COG0561	phosphatase activity
I5776_RS13535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5776_RS13540	COG0569	domain protein
I5776_RS13545	COG2197	response regulator
I5776_RS13550	COG4585	Histidine kinase
I5776_RS13555	COG4758	membrane
I5776_RS13570	COG1132	(ABC) transporter
I5776_RS13575	COG1132	(ABC) transporter
I5776_RS13580	COG0668	transmembrane transport
I5776_RS13585	COG1473	amidohydrolase
I5776_RS13590	COG2171	N-acyltransferase activity
I5776_RS13595	COG0583	DNA-binding transcription factor activity
I5776_RS13600	COG1595	DNA-templated transcription, initiation
I5776_RS13610	COG0517	IMP dehydrogenase activity
I5776_RS13620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS13635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5776_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS13650	COG3300	MHYT domain
I5776_RS13650	COG5001	Diguanylate cyclase
I5776_RS13660	COG0784	Response regulator, receiver
I5776_RS13660	COG0835	chemotaxis
I5776_RS13665	COG0436	Aminotransferase
I5776_RS13675	COG2084	Dehydrogenase
I5776_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS13685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5776_RS13705	COG0714	Associated with various cellular activities
I5776_RS13715	COG4873	Protein conserved in bacteria
I5776_RS13725	COG3949	Membrane
I5776_RS13730	COG0542	response to heat
I5776_RS13740	COG1846	Transcriptional regulator
I5776_RS13745	COG3852	Histidine kinase
I5776_RS13755	COG1032	radical SAM domain protein
I5776_RS13770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5776_RS13785	COG1191	sigma factor activity
I5776_RS13790	COG0861	Integral membrane protein TerC family
I5776_RS13825	COG3764	Sortase (surface protein transpeptidase)
I5776_RS13835	COG1757	Na H antiporter
I5776_RS13840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5776_RS13855	COG1363	Peptidase, m42
I5776_RS13860	COG1764	response to oxidative stress
I5776_RS13870	COG0673	inositol 2-dehydrogenase activity
I5776_RS13885	COG1575	Belongs to the MenA family. Type 1 subfamily
I5776_RS13895	COG2382	esterase
I5776_RS13905	COG2153	protein acetylation
I5776_RS13915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5776_RS13920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5776_RS13925	COG1116	anion transmembrane transporter activity
I5776_RS13930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS13935	COG2814	Major facilitator Superfamily
I5776_RS13960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5776_RS14020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I5776_RS14020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5776_RS14045	COG0463	Glycosyl transferase, family 2
I5776_RS14045	COG0457	Tetratricopeptide repeat
I5776_RS14055	COG0673	inositol 2-dehydrogenase activity
I5776_RS14090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5776_RS14095	COG0475	glutathione-regulated potassium exporter activity
I5776_RS14095	COG0569	domain protein
I5776_RS14100	COG2239	Acts as a magnesium transporter
I5776_RS14105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5776_RS14115	COG0564	pseudouridine synthase activity
I5776_RS14125	COG2357	RelA SpoT domain protein
I5776_RS14130	COG4116	CYTH
I5776_RS14135	COG0741	lytic transglycosylase activity
I5776_RS14140	COG2346	COG2346, Truncated hemoglobins
I5776_RS14145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5776_RS14150	COG1164	Oligoendopeptidase f
I5776_RS14155	COG4469	Competence protein
I5776_RS14160	COG4862	establishment of competence for transformation
I5776_RS14165	COG1393	Belongs to the ArsC family
I5776_RS14170	COG0180	Tryptophanyl-tRNA synthetase
I5776_RS14180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS14185	COG0601	transmembrane transport
I5776_RS14190	COG0747	negative chemotaxis
I5776_RS14195	COG4608	Belongs to the ABC transporter superfamily
I5776_RS14200	COG0444	Belongs to the ABC transporter superfamily
I5776_RS14205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS14210	COG0601	transmembrane transport
I5776_RS14215	COG0747	negative chemotaxis
I5776_RS14220	COG4608	Belongs to the ABC transporter superfamily
I5776_RS14225	COG0444	Belongs to the ABC transporter superfamily
I5776_RS14230	COG5504	Zn-dependent protease
I5776_RS14250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5776_RS14255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5776_RS14280	COG2267	carboxylic ester hydrolase activity
I5776_RS14290	COG0542	response to heat
I5776_RS14300	COG2151	metal-sulfur cluster biosynthetic enzyme
I5776_RS14305	COG1073	alpha beta
I5776_RS14310	COG0561	phosphatase activity
I5776_RS14330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5776_RS14335	COG1307	EDD domain protein, DegV family
I5776_RS14350	COG1666	GTP binding
I5776_RS14355	COG0456	acetyltransferase
I5776_RS14355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5776_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS14365	COG1874	Beta-galactosidase
I5776_RS14365	COG0366	Alpha amylase catalytic
I5776_RS14380	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5776_RS14385	COG2311	Membrane
I5776_RS14420	COG1074	ATP-dependent DNA helicase activity
I5776_RS14425	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I5776_RS14435	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS14440	COG2610	gluconate transmembrane transporter activity
I5776_RS14450	COG0398	Pfam SNARE associated Golgi protein
I5776_RS14455	COG1506	peptidase
I5776_RS14455	COG0823	Involved in the tonB-independent uptake of proteins
I5776_RS14455	COG4946	Tricorn protease homolog
I5776_RS14465	COG4903	ComK protein
I5776_RS14475	COG0501	Belongs to the peptidase M48B family
I5776_RS14480	COG2755	lipolytic protein G-D-S-L family
I5776_RS14485	COG1024	Enoyl-CoA hydratase
I5776_RS14490	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS14495	COG0095	Lipoate-protein ligase
I5776_RS14500	COG1234	tRNA 3'-trailer cleavage
I5776_RS14510	COG1999	signal sequence binding
I5776_RS14515	COG1511	domain protein
I5776_RS14520	COG1309	transcriptional regulator
I5776_RS14525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5776_RS14530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5776_RS14535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5776_RS14545	COG2197	response regulator
I5776_RS14550	COG4585	Histidine kinase
I5776_RS14560	COG3069	C4-dicarboxylate transmembrane transporter activity
I5776_RS14565	COG1473	amidohydrolase
I5776_RS14575	COG4473	ABC transporter
I5776_RS14580	COG1131	(ABC) transporter
I5776_RS14585	COG0537	adenosine 5'-monophosphoramidase activity
I5776_RS14595	COG1846	Transcriptional regulator
I5776_RS14610	COG2860	membrane
I5776_RS14615	COG5609	conserved protein (DUF2294)
I5776_RS14625	COG2427	Protein of unknown function (DUF1641)
I5776_RS14630	COG3383	formate dehydrogenase (NAD+) activity
I5776_RS14640	COG0314	molybdopterin synthase activity
I5776_RS14645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5776_RS14655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5776_RS14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5776_RS14680	COG3481	metal-dependent phosphohydrolase, HD sub domain
I5776_RS14685	COG4717	serine-type aminopeptidase activity
I5776_RS14690	COG0420	3'-5' exonuclease activity
I5776_RS14695	COG1668	transmembrane transport
I5776_RS14700	COG4152	abc transporter atp-binding protein
I5776_RS14705	COG0861	Integral membrane protein TerC family
I5776_RS14715	COG1024	Enoyl-CoA hydratase
I5776_RS14725	COG2814	Major facilitator Superfamily
I5776_RS14730	COG0561	phosphatase activity
I5776_RS14735	COG3679	Belongs to the UPF0342 family
I5776_RS14745	COG0189	ligase activity
I5776_RS14750	COG0189	ligase activity
I5776_RS14770	COG2508	Transcriptional regulator
I5776_RS14775	COG3842	ATPase activity
I5776_RS14795	COG2814	Major facilitator Superfamily
I5776_RS14800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5776_RS14810	COG3859	Proton-coupled thiamine transporter YuaJ
I5776_RS14815	COG3852	Histidine kinase
I5776_RS14835	COG0659	secondary active sulfate transmembrane transporter activity
I5776_RS14840	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS14850	COG4608	Belongs to the ABC transporter superfamily
I5776_RS14855	COG0791	NLP P60 protein
I5776_RS14860	COG4166	transmembrane transport
I5776_RS14865	COG0444	Belongs to the ABC transporter superfamily
I5776_RS14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS14875	COG0601	transmembrane transport
I5776_RS14885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5776_RS14895	COG0598	Magnesium transport protein CorA
I5776_RS14900	COG1280	lysine exporter protein (LysE YggA)
I5776_RS14905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5776_RS14915	COG1253	flavin adenine dinucleotide binding
I5776_RS14925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5776_RS14925	COG1017	nitric oxide dioxygenase activity
I5776_RS14930	COG2719	SpoVR family
I5776_RS14950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5776_RS14960	COG0564	pseudouridine synthase activity
I5776_RS14975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5776_RS14980	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5776_RS14985	COG1392	Phosphate transport regulator
I5776_RS14990	COG0306	phosphate transporter
I5776_RS14995	COG3344	reverse transcriptase
I5776_RS15000	COG2252	PERMEase
I5776_RS15020	COG1309	transcriptional regulator
I5776_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS15035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5776_RS15045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5776_RS15090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5776_RS15090	COG1116	anion transmembrane transporter activity
I5776_RS15110	COG3327	negative regulation of DNA-templated transcription, initiation
I5776_RS15115	COG0183	Belongs to the thiolase family
I5776_RS15120	COG1024	Enoyl-CoA hydratase
I5776_RS15135	COG2151	metal-sulfur cluster biosynthetic enzyme
I5776_RS15150	COG3396	Phenylacetate-CoA oxygenase
I5776_RS15155	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5776_RS15160	COG3104	oligopeptide transport
I5776_RS15185	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5776_RS15205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5776_RS15210	COG0583	DNA-binding transcription factor activity
I5776_RS15225	COG0726	polysaccharide deacetylase
I5776_RS15230	COG0604	alcohol dehydrogenase
I5776_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS15230	COG3321	synthase
I5776_RS15260	COG4257	antibiotic catabolic process
I5776_RS15280	COG0596	Alpha beta hydrolase
I5776_RS15285	COG2208	phosphoserine phosphatase activity
I5776_RS15290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5776_RS15295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5776_RS15295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5776_RS15300	COG0307	riboflavin synthase, alpha
I5776_RS15305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5776_RS15305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5776_RS15310	COG1929	Belongs to the glycerate kinase type-1 family
I5776_RS15320	COG1414	Transcriptional regulator
I5776_RS15345	COG2766	serine protein kinase
I5776_RS15350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5776_RS15360	COG1846	Transcriptional regulator
I5776_RS15365	COG2814	Major facilitator Superfamily
I5776_RS15375	COG0640	Transcriptional regulator
I5776_RS15380	COG0604	alcohol dehydrogenase
I5776_RS15390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5776_RS15400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5776_RS15400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5776_RS15405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5776_RS15415	COG1131	(ABC) transporter
I5776_RS15420	COG2755	lipolytic protein G-D-S-L family
I5776_RS15435	COG0346	lactoylglutathione lyase activity
I5776_RS15495	COG2226	methyltransferase
I5776_RS15510	COG0673	inositol 2-dehydrogenase activity
I5776_RS15540	COG2814	Major facilitator Superfamily
I5776_RS15545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5776_RS15570	COG2318	DinB family
I5776_RS15590	COG0477	Major facilitator Superfamily
I5776_RS15610	COG0398	Pfam SNARE associated Golgi protein
I5776_RS15625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5776_RS15635	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5776_RS15640	COG0756	dUTP diphosphatase activity
I5776_RS15645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5776_RS15650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5776_RS15665	COG3264	Mechanosensitive ion channel
I5776_RS15665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I5776_RS15700	COG4221	oxidoreductase activity
I5776_RS15725	COG1595	DNA-templated transcription, initiation
I5776_RS15795	COG0305	Participates in initiation and elongation during chromosome replication
I5776_RS15820	COG4941	Belongs to the sigma-70 factor family
I5776_RS15835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5776_RS15875	COG0531	amino acid
I5776_RS15890	COG3684	Belongs to the aldolase LacD family
I5776_RS15895	COG1105	Belongs to the carbohydrate kinase PfkB family
I5776_RS15900	COG2222	sugar isomerase
I5776_RS15905	COG1940	carbohydrate kinase activity
I5776_RS15910	COG0395	ABC-type sugar transport system, permease component
I5776_RS15915	COG1175	transmembrane transport
I5776_RS15935	COG2188	Transcriptional regulator
I5776_RS15940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS15950	COG2319	Wd-40 repeat
I5776_RS15950	COG4249	Peptidase C14 caspase catalytic subunit p20
I5776_RS15955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5776_RS15960	COG0732	type I restriction modification DNA specificity domain
I5776_RS15965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5776_RS15970	COG2258	MOSC domain
I5776_RS16080	COG0735	belongs to the Fur family
I5776_RS16085	COG2096	Adenosyltransferase
I5776_RS16090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5776_RS16095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5776_RS16105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5776_RS16110	COG4129	membrane
I5776_RS16115	COG1132	(ABC) transporter
I5776_RS16120	COG3557	Belongs to the UPF0374 family
I5776_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS16145	COG0583	DNA-binding transcription factor activity
I5776_RS16150	COG0067	glutamate synthase
I5776_RS16150	COG0070	glutamate synthase
I5776_RS16150	COG0069	glutamate synthase activity
I5776_RS16155	COG0493	'glutamate synthase
I5776_RS16160	COG1194	a g-specific adenine glycosylase
I5776_RS16165	COG1988	membrane-bound metal-dependent
I5776_RS16180	COG2137	regulation of response to DNA damage stimulus
I5776_RS16195	COG0159	tryptophan synthase activity
I5776_RS16200	COG0133	tryptophan synthase activity
I5776_RS16205	COG0135	phosphoribosylanthranilate isomerase activity
I5776_RS16215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5776_RS16220	COG0512	Glutamine amidotransferase of anthranilate synthase
I5776_RS16220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5776_RS16225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5776_RS16235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5776_RS16240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5776_RS16245	COG0110	maltose O-acetyltransferase activity
I5776_RS16250	COG0546	phosphoglycolate phosphatase activity
I5776_RS16255	COG0066	3-isopropylmalate dehydratase activity
I5776_RS16260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5776_RS16270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5776_RS16275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5776_RS16280	COG0440	acetolactate synthase activity
I5776_RS16285	COG0028	Belongs to the TPP enzyme family
I5776_RS16290	COG0129	dihydroxy-acid dehydratase activity
I5776_RS16300	COG0460	homoserine dehydrogenase
I5776_RS16305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5776_RS16310	COG0083	homoserine kinase activity
I5776_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS16330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5776_RS16340	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS16345	COG0028	Belongs to the TPP enzyme family
I5776_RS16350	COG0069	glutamate synthase activity
I5776_RS16360	COG2814	Major facilitator Superfamily
I5776_RS16365	COG0789	Transcriptional regulator
I5776_RS16400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5776_RS16405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5776_RS16410	COG0733	neurotransmitter:sodium symporter activity
I5776_RS16415	COG1605	Chorismate mutase
I5776_RS16415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5776_RS16420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5776_RS16425	COG0095	Lipoate-protein ligase
I5776_RS16430	COG1051	belongs to the nudix hydrolase family
I5776_RS16440	COG0583	DNA-binding transcription factor activity
I5776_RS16445	COG1607	acyl-coa hydrolase
I5776_RS16460	COG0071	Belongs to the small heat shock protein (HSP20) family
I5776_RS16495	COG4895	conserved protein (DUF2196)
I5776_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS16510	COG3243	poly(R)-hydroxyalkanoic acid synthase
I5776_RS16520	COG1136	(ABC) transporter
I5776_RS16525	COG0577	efflux transmembrane transporter activity
I5776_RS16530	COG0745	RESPONSE REGULATOR receiver
I5776_RS16535	COG5002	protein histidine kinase activity
I5776_RS16555	COG1732	Glycine betaine
I5776_RS16570	COG0477	Major facilitator Superfamily
I5776_RS16575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5776_RS16585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I5776_RS16595	COG1696	Membrane protein involved in D-alanine export
I5776_RS16600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5776_RS16610	COG0686	Belongs to the AlaDH PNT family
I5776_RS16615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5776_RS16615	COG2508	Transcriptional regulator
I5776_RS16620	COG1113	amino acid transport
I5776_RS16630	COG1115	amino acid carrier protein
I5776_RS16640	COG0617	tRNA 3'-terminal CCA addition
I5776_RS16640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5776_RS16640	COG0517	IMP dehydrogenase activity
I5776_RS16650	COG2346	COG2346, Truncated hemoglobins
I5776_RS16655	COG2304	oxidoreductase activity
I5776_RS16670	COG2076	Multidrug Resistance protein
I5776_RS16675	COG2076	Multidrug Resistance protein
I5776_RS16680	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5776_RS16685	COG1129	ABC transporter
I5776_RS16695	COG0673	inositol 2-dehydrogenase activity
I5776_RS16725	COG2814	Major facilitator Superfamily
I5776_RS16740	COG1063	alcohol dehydrogenase
I5776_RS16745	COG0583	DNA-binding transcription factor activity
I5776_RS16755	COG2409	Drug exporters of the RND superfamily
I5776_RS16755	COG1033	growth of symbiont in host cell
I5776_RS16765	COG0393	Putative heavy-metal-binding
I5776_RS16820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5776_RS16830	COG0791	NLP P60 protein
I5776_RS16830	COG1388	LysM domain
I5776_RS16830	COG3103	Sh3 type 3 domain protein
I5776_RS16835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5776_RS16845	COG3711	transcriptional antiterminator
I5776_RS16855	COG2264	protein methyltransferase activity
I5776_RS16880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5776_RS16885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5776_RS16890	COG1396	sequence-specific DNA binding
I5776_RS16925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5776_RS16930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5776_RS16935	COG2169	Transcriptional regulator
I5776_RS16960	COG0535	radical SAM domain protein
I5776_RS16995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5776_RS17020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5776_RS17030	COG3620	sequence-specific DNA binding
I5776_RS17040	COG0577	efflux transmembrane transporter activity
I5776_RS17045	COG1136	(ABC) transporter
I5776_RS17050	COG2205	protein histidine kinase activity
I5776_RS17055	COG0745	RESPONSE REGULATOR receiver
I5776_RS17060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5776_RS17075	COG0697	spore germination
I5776_RS17085	COG0697	spore germination
I5776_RS17115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5776_RS17150	COG4122	O-methyltransferase activity
I5776_RS17160	COG1335	isochorismatase
I5776_RS17175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I5776_RS17180	COG2252	PERMEase
I5776_RS17195	COG0387	Pfam Sodium calcium exchanger
I5776_RS17200	COG0477	Major facilitator Superfamily
I5776_RS17205	COG2217	Heavy metal translocating P-type atpase
I5776_RS17215	COG1295	ribonuclease BN
I5776_RS17220	COG4840	Belongs to the UPF0435 family
I5776_RS17235	COG0024	Methionine aminopeptidase
I5776_RS17240	COG1360	Flagellar Motor Protein
I5776_RS17245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5776_RS17265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5776_RS17295	COG3300	MHYT domain
I5776_RS17295	COG5001	Diguanylate cyclase
I5776_RS17320	COG1595	DNA-templated transcription, initiation
I5776_RS17330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5776_RS17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS17345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS17350	COG0693	protein deglycase activity
I5776_RS17365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5776_RS17375	COG4948	Mandelate Racemase Muconate Lactonizing
I5776_RS17390	COG1388	LysM domain
I5776_RS17395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5776_RS17395	COG0456	acetyltransferase
I5776_RS17420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5776_RS17465	COG0246	Mannitol dehydrogenase
I5776_RS17470	COG3711	transcriptional antiterminator
I5776_RS17485	COG1959	2 iron, 2 sulfur cluster binding
I5776_RS17490	COG3189	MarR family transcriptional regulator
I5776_RS17495	COG1960	acyl-CoA dehydrogenase activity
I5776_RS17500	COG0318	PFAM AMP-dependent synthetase and ligase
I5776_RS17510	COG2309	aminopeptidase activity
I5776_RS17520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5776_RS17525	COG2986	histidine ammonia-lyase
I5776_RS17530	COG1607	acyl-coa hydrolase
I5776_RS17540	COG0701	Predicted permease
I5776_RS17545	COG3689	TIGRFAM TIGR03943 family protein
I5776_RS17550	COG1077	Cell shape determining protein MreB Mrl
I5776_RS17560	COG2268	Band 7 protein
I5776_RS17565	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5776_RS17575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5776_RS17580	COG0626	cystathionine gamma-synthase activity
I5776_RS17585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5776_RS17590	COG2226	methyltransferase
I5776_RS17600	COG5002	protein histidine kinase activity
I5776_RS17625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5776_RS17625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS17625	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5776_RS17630	COG1461	Dihydroxyacetone kinase
I5776_RS17635	COG2376	Dihydroxyacetone kinase
I5776_RS17640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5776_RS17645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5776_RS17650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5776_RS17655	COG1063	alcohol dehydrogenase
I5776_RS17665	COG1252	NADH dehydrogenase
I5776_RS17675	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I5776_RS17680	COG1518	maintenance of DNA repeat elements
I5776_RS17745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS17755	COG0285	dihydrofolate synthase activity
I5776_RS17760	COG3706	GGDEF domain
I5776_RS17765	COG1414	Transcriptional regulator
I5776_RS17775	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS17780	COG0028	Belongs to the TPP enzyme family
I5776_RS17785	COG0436	Aminotransferase
I5776_RS17795	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5776_RS17800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS17805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS17810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5776_RS17810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5776_RS17815	COG2244	polysaccharide biosynthetic process
I5776_RS17820	COG1785	Belongs to the alkaline phosphatase family
I5776_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS17830	COG1268	BioY protein
I5776_RS17835	COG0024	Methionine aminopeptidase
I5776_RS17840	COG0791	NLP P60 protein
I5776_RS17840	COG1388	LysM domain
I5776_RS17845	COG0488	(ABC) transporter
I5776_RS17850	COG0673	inositol 2-dehydrogenase activity
I5776_RS17865	COG0488	(ABC) transporter
I5776_RS17885	COG0513	Belongs to the DEAD box helicase family
I5776_RS17900	COG3973	AAA domain
I5776_RS17905	COG1278	Cold shock
I5776_RS17915	COG1388	LysM domain
I5776_RS17915	COG3584	3D domain protein
I5776_RS17935	COG2318	DinB family
I5776_RS17940	COG0527	aspartate kinase activity
I5776_RS17965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5776_RS17970	COG1116	anion transmembrane transporter activity
I5776_RS17975	COG0166	Belongs to the GPI family
I5776_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
I5776_RS17985	COG1132	(ABC) transporter
I5776_RS17990	COG1132	(ABC) transporter
I5776_RS17995	COG0406	alpha-ribazole phosphatase activity
I5776_RS18000	COG5566	PFAM Mor transcription activator
I5776_RS18010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5776_RS18015	COG3420	alginic acid biosynthetic process
I5776_RS18025	COG1131	(ABC) transporter
I5776_RS18035	COG0697	spore germination
I5776_RS18040	COG3695	enzyme binding
I5776_RS18055	COG2814	Major facilitator Superfamily
I5776_RS18065	COG0534	Mate efflux family protein
I5776_RS18075	COG3876	Protein conserved in bacteria
I5776_RS18080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5776_RS18085	COG1472	Belongs to the glycosyl hydrolase 3 family
I5776_RS18095	COG0390	transport system, permease component
I5776_RS18100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5776_RS18110	COG0697	spore germination
I5776_RS18120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5776_RS18125	COG2027	D-alanyl-D-alanine carboxypeptidase
I5776_RS18135	COG3290	protein histidine kinase activity
I5776_RS18155	COG3180	Ammonia monooxygenase
I5776_RS18160	COG0583	DNA-binding transcription factor activity
I5776_RS18165	COG3290	protein histidine kinase activity
I5776_RS18170	COG4565	transcriptional regulatory protein
I5776_RS18175	COG2851	Citrate transporter
I5776_RS18180	COG1404	Belongs to the peptidase S8 family
I5776_RS18185	COG4191	Histidine kinase
I5776_RS18190	COG1966	Carbon starvation protein
I5776_RS18210	COG0589	response to stress
I5776_RS18220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5776_RS18225	COG0596	Alpha beta hydrolase
I5776_RS18230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I5776_RS18235	COG3832	glyoxalase III activity
I5776_RS18240	COG0640	Transcriptional regulator
I5776_RS18250	COG1566	PFAM secretion protein HlyD family protein
I5776_RS18255	COG2814	Major facilitator Superfamily
I5776_RS18270	COG0475	glutathione-regulated potassium exporter activity
I5776_RS18275	COG0490	domain, Protein
I5776_RS18280	COG0582	viral genome integration into host DNA
I5776_RS18285	COG0490	domain, Protein
I5776_RS18290	COG0300	oxidoreductase activity
I5776_RS18300	COG0456	acetyltransferase
I5776_RS18315	COG0444	Belongs to the ABC transporter superfamily
I5776_RS18320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5776_RS18325	COG0601	transmembrane transport
I5776_RS18330	COG4166	transmembrane transport
I5776_RS18340	COG0789	Transcriptional regulator
I5776_RS18355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS18355	COG1263	PTS System
I5776_RS18360	COG3711	transcriptional antiterminator
I5776_RS18365	COG2190	(PTS) system
I5776_RS18480	COG0425	Belongs to the sulfur carrier protein TusA family
I5776_RS18485	COG2391	methyltransferase activity
I5776_RS18505	COG0506	proline dehydrogenase activity
I5776_RS18515	COG4149	molybdate abc transporter
I5776_RS18520	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5776_RS18525	COG2814	Major facilitator Superfamily
I5776_RS18540	COG1113	amino acid transport
I5776_RS18545	COG0546	phosphoglycolate phosphatase activity
I5776_RS18550	COG1609	Transcriptional regulator
I5776_RS18555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5776_RS18560	COG3153	acetyltransferase
I5776_RS18560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5776_RS18565	COG0753	catalase activity
I5776_RS18575	COG2201	protein-glutamate methylesterase activity
I5776_RS18580	COG0824	Thioesterase
I5776_RS18590	COG1028	Short-chain dehydrogenase reductase Sdr
I5776_RS18600	COG2197	response regulator
I5776_RS18630	COG0018	arginyl-trna synthetase
I5776_RS18635	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5776_RS18640	COG2271	Major facilitator Superfamily
I5776_RS18650	COG0647	UMP catabolic process
I5776_RS18655	COG1285	pathogenesis
I5776_RS18660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5776_RS18665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5776_RS18670	COG2309	aminopeptidase activity
I5776_RS18675	COG1126	abc transporter atp-binding protein
I5776_RS18680	COG0765	amino acid transport
I5776_RS18685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS18690	COG1876	peptidase activity
I5776_RS18700	COG2814	Major facilitator Superfamily
I5776_RS18740	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5776_RS18745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS18745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5776_RS18750	COG2723	6-phospho-beta-galactosidase activity
I5776_RS18755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5776_RS18760	COG1573	uracil-dna glycosylase
I5776_RS18785	COG4807	Protein conserved in bacteria
I5776_RS18815	COG1090	epimerase
I5776_RS18825	COG0789	Transcriptional regulator
I5776_RS18830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5776_RS18860	COG0500	methyltransferase
I5776_RS18875	COG2226	methyltransferase
I5776_RS18905	COG3173	Aminoglycoside phosphotransferase
I5776_RS18935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5776_RS18950	COG3344	reverse transcriptase
I5776_RS19075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5776_RS19110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5776_RS19120	COG0494	nUDIX hydrolase
I5776_RS19130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5776_RS19135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5776_RS19145	COG4260	virion core protein, lumpy skin disease virus
I5776_RS19150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5776_RS19155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5776_RS19160	COG1842	Phage shock protein A
I5776_RS19165	COG0326	Molecular chaperone. Has ATPase activity
I5776_RS19180	COG0154	amidase activity
I5776_RS19185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5776_RS19190	COG1597	lipid kinase activity
I5776_RS19210	COG1595	DNA-templated transcription, initiation
I5776_RS19235	COG1854	S-ribosylhomocysteine lyase activity
I5776_RS19245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5776_RS19250	COG0400	carboxylic ester hydrolase activity
I5776_RS19255	COG0346	lactoylglutathione lyase activity
I5776_RS19270	COG0154	amidase activity
I5776_RS19275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5776_RS19285	COG2224	Isocitrate lyase
I5776_RS19290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5776_RS19300	COG4851	CamS sex pheromone cAM373 precursor
I5776_RS19305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5776_RS19310	COG0210	DNA helicase
I5776_RS19315	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I5776_RS19330	COG4496	protein, YerC YecD
I5776_RS19335	COG1470	cell adhesion involved in biofilm formation
I5776_RS19350	COG0151	Belongs to the GarS family
I5776_RS19355	COG0138	bifunctional purine biosynthesis protein purh
I5776_RS19360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5776_RS19365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5776_RS19370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5776_RS19385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5776_RS19395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5776_RS19400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5776_RS19405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5776_RS19415	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I5776_RS19435	COG2190	(PTS) system
I5776_RS19435	COG1263	PTS System
I5776_RS19435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS19440	COG3711	transcriptional antiterminator
I5776_RS19445	COG2252	PERMEase
I5776_RS19450	COG0519	Catalyzes the synthesis of GMP from XMP
I5776_RS19450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5776_RS19455	COG1305	Transglutaminase-like
I5776_RS19460	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I5776_RS19465	COG0714	Associated with various cellular activities
I5776_RS19475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5776_RS19480	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5776_RS19485	COG1335	isochorismatase
I5776_RS19490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5776_RS19495	COG1122	ATPase activity
I5776_RS19500	COG4721	ABC-type cobalt transport system, permease component
I5776_RS19510	COG0833	amino acid
I5776_RS19525	COG1266	CAAX protease self-immunity
I5776_RS19535	COG0805	protein transport
I5776_RS19540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5776_RS19545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I5776_RS19550	COG0315	cyclic pyranopterin monophosphate synthase activity
I5776_RS19555	COG0488	(ABC) transporter
I5776_RS19565	COG0456	acetyltransferase
I5776_RS19570	COG1214	PFAM Peptidase M22, glycoprotease
I5776_RS19575	COG0802	atpase or kinase
I5776_RS19660	COG2183	response to ionizing radiation
I5776_RS19665	COG2208	phosphoserine phosphatase activity
I5776_RS19670	COG1191	sigma factor activity
I5776_RS19675	COG2172	sigma factor antagonist activity
I5776_RS19680	COG1366	Belongs to the anti-sigma-factor antagonist family
I5776_RS19685	COG2208	phosphoserine phosphatase activity
I5776_RS19690	COG2172	sigma factor antagonist activity
I5776_RS19695	COG1366	Belongs to the anti-sigma-factor antagonist family
I5776_RS19700	COG1366	Belongs to the anti-sigma-factor antagonist family
I5776_RS19705	COG2337	Toxic component of a toxin-antitoxin (TA) module
I5776_RS19710	COG0864	Transcriptional regulator
I5776_RS19720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5776_RS19725	COG0736	holo-[acyl-carrier-protein] synthase activity
I5776_RS19730	COG0705	Rhomboid family
I5776_RS19735	COG3428	Bacterial PH domain
I5776_RS19740	COG3402	PFAM membrane-flanked domain
I5776_RS19745	COG0513	Belongs to the DEAD box helicase family
I5776_RS19750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5776_RS19755	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5776_RS19765	COG1253	flavin adenine dinucleotide binding
I5776_RS19770	COG0772	Belongs to the SEDS family
I5776_RS19775	COG0789	Transcriptional regulator
I5776_RS19780	COG1253	flavin adenine dinucleotide binding
I5776_RS19790	COG1131	(ABC) transporter
I5776_RS19800	COG2814	Major facilitator Superfamily
I5776_RS19805	COG1664	Polymer-forming cytoskeletal
I5776_RS19815	COG0789	Transcriptional regulator
I5776_RS19835	COG1785	Belongs to the alkaline phosphatase family
I5776_RS19845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5776_RS19855	COG0629	single-stranded DNA binding
I5776_RS19870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5776_RS19880	COG4786	Flagellar basal body rod
I5776_RS19885	COG4786	Flagellar basal body rod
I5776_RS19890	COG1077	Cell shape determining protein MreB Mrl
I5776_RS19895	COG1609	Transcriptional regulator
I5776_RS19900	COG0739	heme binding
I5776_RS19905	COG2385	sporulation resulting in formation of a cellular spore
I5776_RS19915	COG1704	LemA family
I5776_RS19920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5776_RS19930	COG4836	Membrane
I5776_RS19940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5776_RS19945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5776_RS19950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5776_RS19955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5776_RS19960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5776_RS19965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5776_RS19970	COG0356	it plays a direct role in the translocation of protons across the membrane
I5776_RS19980	COG1404	Belongs to the peptidase S8 family
I5776_RS19985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5776_RS19990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5776_RS19995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5776_RS20005	COG0698	ribose 5-phosphate isomerase
I5776_RS20020	COG1971	Probably functions as a manganese efflux pump
I5776_RS20025	COG0009	L-threonylcarbamoyladenylate synthase
I5776_RS20055	COG1435	thymidine kinase activity
I5776_RS20065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5776_RS20070	COG1494	fructose-1,6-bisphosphatase
I5776_RS20075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5776_RS20080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5776_RS20085	COG0191	fructose-bisphosphate aldolase activity
I5776_RS20090	COG2204	response regulator
I5776_RS20100	COG0504	CTP synthase activity
I5776_RS20105	COG3343	RNA polymerase activity
I5776_RS20110	COG1703	isobutyryl-CoA mutase activity
I5776_RS20110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5776_RS20110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5776_RS20120	COG1960	acyl-CoA dehydrogenase activity
I5776_RS20125	COG1960	acyl-CoA dehydrogenase activity
I5776_RS20130	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5776_RS20135	COG0183	Belongs to the thiolase family
I5776_RS20140	COG2181	nitrate reductase activity
I5776_RS20140	COG0247	lactate metabolic process
I5776_RS20145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5776_RS20150	COG0018	arginyl-trna synthetase
I5776_RS20155	COG4506	Protein conserved in bacteria
I5776_RS20160	COG0730	response to heat
I5776_RS20165	COG0010	Belongs to the arginase family
I5776_RS20170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5776_RS20175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5776_RS20185	COG1994	Peptidase M50
I5776_RS20195	COG3465	dGTPase activity
I5776_RS20200	COG1078	dGTPase activity
I5776_RS20210	COG1132	(ABC) transporter
I5776_RS20215	COG1132	(ABC) transporter
I5776_RS20225	COG0280	phosphate acetyltransferase
I5776_RS20240	COG2363	Small membrane protein
I5776_RS20255	COG0314	molybdopterin synthase activity
I5776_RS20260	COG0746	molybdenum cofactor guanylyltransferase activity
I5776_RS20265	COG0346	lactoylglutathione lyase activity
I5776_RS20275	COG0351	phosphomethylpyrimidine kinase
I5776_RS20280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5776_RS20290	COG1131	(ABC) transporter
I5776_RS20300	COG1309	transcriptional regulator
I5776_RS20305	COG0561	phosphatase activity
I5776_RS20310	COG2031	fatty acid transporter
I5776_RS20315	COG0514	ATP-dependent DNA helicase (RecQ)
I5776_RS20320	COG4191	Histidine kinase
I5776_RS20330	COG0156	8-amino-7-oxononanoate synthase activity
I5776_RS20340	COG1263	PTS System
I5776_RS20340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5776_RS20355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5776_RS20375	COG3279	Response regulator of the LytR AlgR family
I5776_RS20380	COG0427	acetyl-CoA hydrolase
I5776_RS20385	COG1823	symporter activity
I5776_RS20390	COG0737	Belongs to the 5'-nucleotidase family
I5776_RS20395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5776_RS20405	COG3639	organic phosphonate transmembrane transporter activity
I5776_RS20415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5776_RS20430	COG0367	asparagine synthase
I5776_RS20440	COG2966	Psort location CytoplasmicMembrane, score
I5776_RS20460	COG4607	ABC-type enterochelin transport system periplasmic component
I5776_RS20465	COG4604	ABC transporter, ATP-binding protein
I5776_RS20470	COG4605	iron ion homeostasis
I5776_RS20475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5776_RS20480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5776_RS20495	COG0765	amino acid transport
I5776_RS20510	COG0488	(ABC) transporter
I5776_RS20515	COG0531	amino acid
I5776_RS20525	COG0840	transmembrane signaling receptor activity
I5776_RS20530	COG0492	ferredoxin-NADP+ reductase activity
I5776_RS20560	COG1301	dicarboxylic acid transport
I5776_RS20575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5776_RS20580	COG1309	transcriptional regulator
I5776_RS20585	COG1132	(ABC) transporter
I5776_RS20600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5776_RS20605	COG2068	MobA-Related Protein
I5776_RS20610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5776_RS20665	COG2259	Doxx family
I5776_RS20670	COG0534	Mate efflux family protein
I5776_RS20675	COG0840	transmembrane signaling receptor activity
I5776_RS20675	COG3290	protein histidine kinase activity
I5776_RS20680	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5776_RS20685	COG0730	response to heat
I5776_RS20690	COG0425	Belongs to the sulfur carrier protein TusA family
I5776_RS20695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5776_RS20695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5776_RS20700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5776_RS20700	COG0425	Belongs to the sulfur carrier protein TusA family
I5776_RS20710	COG2210	Belongs to the sulfur carrier protein TusA family
I5776_RS20715	COG1937	Protein conserved in bacteria
I5776_RS20740	COG1131	(ABC) transporter
I5776_RS20755	COG3844	kynureninase activity
I5776_RS20765	COG2199	diguanylate cyclase activity
I5776_RS20770	COG3104	oligopeptide transport
I5776_RS20790	COG0805	protein transport
I5776_RS20805	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5776_RS20830	COG4989	oxidoreductase activity
I5776_RS20835	COG0745	RESPONSE REGULATOR receiver
I5776_RS20840	COG0642	Histidine kinase
I5776_RS20845	COG1136	(ABC) transporter
I5776_RS20850	COG0577	efflux transmembrane transporter activity
I5776_RS20860	COG4549	nuclear export factor GLE1
I5776_RS20865	COG1276	copper resistance
I5776_RS20865	COG2372	response to copper ion
I5776_RS20870	COG1349	DNA-binding transcription factor activity
I5776_RS20880	COG1070	Carbohydrate kinase
I5776_RS20895	COG2972	Histidine kinase
I5776_RS20900	COG4753	response regulator
I5776_RS20900	COG2207	Transcriptional regulator
I5776_RS20905	COG4213	ABC transporter substrate-binding protein
I5776_RS20910	COG4213	ABC transporter substrate-binding protein
I5776_RS20920	COG4214	carbohydrate transport
I5776_RS20925	COG0450	alkyl hydroperoxide reductase
I5776_RS20930	COG3634	alkyl hydroperoxide reductase activity
I5776_RS20935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5776_RS20940	COG0579	oxidoreductase
I5776_RS20945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5776_RS20955	COG0402	S-adenosylhomocysteine deaminase activity
I5776_RS20960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5776_RS20995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5776_RS21025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I5776_RS21105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5776_RS21115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5776_RS21120	COG0210	DNA helicase
I5776_RS21165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5776_RS21170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5776_RS21175	COG4853	Protein conserved in bacteria
I5776_RS21185	COG5002	protein histidine kinase activity
I5776_RS21190	COG0745	RESPONSE REGULATOR receiver
I5776_RS21215	COG0305	Participates in initiation and elongation during chromosome replication
I5776_RS21220	COG0359	binds to the 23S rRNA
I5776_RS21225	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I5776_RS21230	COG4241	membrane
I5776_RS21235	COG0840	transmembrane signaling receptor activity
I5776_RS21240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5776_RS21250	COG0360	Binds together with S18 to 16S ribosomal RNA
I5776_RS21255	COG0012	GTP binding
I5776_RS21260	COG4481	Protein conserved in bacteria
I5776_RS21265	COG0668	transmembrane transport
I5776_RS21280	COG1475	DNA binding
I5776_RS21285	COG1192	Involved in chromosome partitioning
I5776_RS21290	COG1475	DNA binding
I5776_RS21300	COG0445	tRNA wobble uridine modification
I5776_RS21310	COG1847	R3H domain protein
I5776_RS21325	COG0230	Belongs to the bacterial ribosomal protein bL34 family