locus-tag	class	description
D4A37_RS00010	COG0592	DNA-directed DNA polymerase activity
D4A37_RS00015	COG2501	S4 domain
D4A37_RS00025	COG0187	DNA topoisomerase II activity
D4A37_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4A37_RS00065	COG0516	GMP reductase activity
D4A37_RS00065	COG0517	IMP dehydrogenase activity
D4A37_RS00070	COG1686	Belongs to the peptidase S11 family
D4A37_RS00100	COG1428	Deoxynucleoside kinase
D4A37_RS00105	COG1428	Deoxynucleoside kinase
D4A37_RS00110	COG1335	isochorismatase
D4A37_RS00115	COG0590	tRNA wobble adenosine to inosine editing
D4A37_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D4A37_RS00180	COG1982	Orn Lys Arg decarboxylase major
D4A37_RS00190	COG0470	DNA polymerase III
D4A37_RS00195	COG1774	PSP1 C-terminal conserved region
D4A37_RS00200	COG4467	Involved in initiation control of chromosome replication
D4A37_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D4A37_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D4A37_RS00220	COG2002	toxin-antitoxin pair type II binding
D4A37_RS00230	COG0084	hydrolase, TatD family'
D4A37_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D4A37_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D4A37_RS00250	COG4466	Protein conserved in bacteria
D4A37_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D4A37_RS00270	COG0251	oxidation-reduction process
D4A37_RS00275	COG2088	sporulation resulting in formation of a cellular spore
D4A37_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D4A37_RS00305	COG2002	toxin-antitoxin pair type II binding
D4A37_RS00310	COG2244	polysaccharide biosynthetic process
D4A37_RS00315	COG3956	TIGRFAM MazG family protein
D4A37_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D4A37_RS00340	COG1098	S1 RNA binding domain
D4A37_RS00355	COG2208	phosphoserine phosphatase activity
D4A37_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D4A37_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A37_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4A37_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4A37_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
D4A37_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A37_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D4A37_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D4A37_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D4A37_RS00420	COG1396	sequence-specific DNA binding
D4A37_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D4A37_RS00515	COG3880	PFAM UvrB UvrC protein
D4A37_RS00525	COG0542	response to heat
D4A37_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D4A37_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
D4A37_RS00560	COG1045	serine acetyltransferase
D4A37_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4A37_RS00580	COG3688	RNA-binding protein containing a PIN domain
D4A37_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4A37_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
D4A37_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D4A37_RS00620	COG0222	ribosome binding
D4A37_RS00625	COG2813	Specifically methylates the guanine in position
D4A37_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D4A37_RS00640	COG1358	cellular component organization or biogenesis
D4A37_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D4A37_RS00665	COG0051	transcription antitermination factor activity, RNA binding
D4A37_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D4A37_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
D4A37_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D4A37_RS00760	COG1841	ribosomal large subunit assembly
D4A37_RS00770	COG0201	protein transport
D4A37_RS00780	COG0024	Methionine aminopeptidase
D4A37_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D4A37_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D4A37_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS00855	COG0489	protein tyrosine kinase activity
D4A37_RS00865	COG2194	sulfuric ester hydrolase activity
D4A37_RS00870	COG0726	polysaccharide deacetylase
D4A37_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D4A37_RS00955	COG4856	YbbR-like protein
D4A37_RS00975	COG4946	Tricorn protease homolog
D4A37_RS00975	COG0823	Involved in the tonB-independent uptake of proteins
D4A37_RS00975	COG1506	peptidase
D4A37_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS01005	COG2011	ABC-type metal ion transport system permease component
D4A37_RS01015	COG1464	Belongs to the NlpA lipoprotein family
D4A37_RS01020	COG0604	alcohol dehydrogenase
D4A37_RS01030	COG0277	FAD linked oxidase domain protein
D4A37_RS01035	COG2271	Major facilitator Superfamily
D4A37_RS01045	COG2814	Major facilitator Superfamily
D4A37_RS01060	COG0601	transmembrane transport
D4A37_RS01065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A37_RS01070	COG0444	Belongs to the ABC transporter superfamily
D4A37_RS01075	COG4608	Belongs to the ABC transporter superfamily
D4A37_RS01080	COG4166	transmembrane transport
D4A37_RS01090	COG2207	Transcriptional regulator
D4A37_RS01100	COG1309	transcriptional regulator
D4A37_RS01110	COG4166	transmembrane transport
D4A37_RS01115	COG4166	transmembrane transport
D4A37_RS01120	COG0656	L-ascorbic acid biosynthetic process
D4A37_RS01140	COG4149	molybdate abc transporter
D4A37_RS01145	COG0725	ABC transporter, periplasmic molybdate-binding protein
D4A37_RS01150	COG1910	domain protein
D4A37_RS01165	COG0697	spore germination
D4A37_RS01180	COG0204	Acyl-transferase
D4A37_RS01190	COG1609	Transcriptional regulator
D4A37_RS01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS01210	COG0084	hydrolase, TatD family'
D4A37_RS01220	COG5298	Protein conserved in bacteria
D4A37_RS01240	COG0488	(ABC) transporter
D4A37_RS01250	COG0747	negative chemotaxis
D4A37_RS01255	COG0747	negative chemotaxis
D4A37_RS01260	COG0601	transmembrane transport
D4A37_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A37_RS01270	COG0444	Belongs to the ABC transporter superfamily
D4A37_RS01275	COG4608	Belongs to the ABC transporter superfamily
D4A37_RS01280	COG0561	phosphatase activity
D4A37_RS01310	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D4A37_RS01315	COG0179	Fumarylacetoacetate (FAA) hydrolase
D4A37_RS01330	COG0531	amino acid
D4A37_RS01345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D4A37_RS01355	COG4294	response to UV
D4A37_RS01360	COG0705	Rhomboid family
D4A37_RS01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D4A37_RS01375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D4A37_RS01380	COG0864	Transcriptional regulator
D4A37_RS01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
D4A37_RS01390	COG2183	response to ionizing radiation
D4A37_RS01490	COG0802	atpase or kinase
D4A37_RS01495	COG1214	PFAM Peptidase M22, glycoprotease
D4A37_RS01500	COG0456	acetyltransferase
D4A37_RS01510	COG0488	(ABC) transporter
D4A37_RS01525	COG1266	CAAX protease self-immunity
D4A37_RS01535	COG0459	protein refolding
D4A37_RS01545	COG2252	PERMEase
D4A37_RS01555	COG5002	protein histidine kinase activity
D4A37_RS01580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D4A37_RS01620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A37_RS01630	COG1215	transferase activity, transferring glycosyl groups
D4A37_RS01650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS01655	COG0506	proline dehydrogenase activity
D4A37_RS01680	COG0697	spore germination
D4A37_RS01700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D4A37_RS01705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D4A37_RS01710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D4A37_RS01720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D4A37_RS01735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D4A37_RS01745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D4A37_RS01755	COG0151	Belongs to the GarS family
D4A37_RS01780	COG0210	DNA helicase
D4A37_RS01790	COG4851	CamS sex pheromone cAM373 precursor
D4A37_RS01805	COG1335	isochorismatase
D4A37_RS01815	COG2011	ABC-type metal ion transport system permease component
D4A37_RS01820	COG1464	Belongs to the NlpA lipoprotein family
D4A37_RS01830	COG0003	Pfam Anion-transporting ATPase
D4A37_RS01835	COG1846	Transcriptional regulator
D4A37_RS01840	COG4682	membrane
D4A37_RS01860	COG1597	lipid kinase activity
D4A37_RS01865	COG0546	phosphoglycolate phosphatase activity
D4A37_RS01870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D4A37_RS01880	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS01885	COG2076	Multidrug Resistance protein
D4A37_RS01890	COG2309	aminopeptidase activity
D4A37_RS01905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS01915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D4A37_RS01925	COG4807	Protein conserved in bacteria
D4A37_RS01950	COG1757	Na H antiporter
D4A37_RS01955	COG1473	amidohydrolase
D4A37_RS01970	COG0450	alkyl hydroperoxide reductase
D4A37_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS02010	COG0492	ferredoxin-NADP+ reductase activity
D4A37_RS02025	COG0166	Belongs to the GPI family
D4A37_RS02050	COG5002	protein histidine kinase activity
D4A37_RS02070	COG3541	Predicted nucleotidyltransferase
D4A37_RS02075	COG2814	Major facilitator Superfamily
D4A37_RS02080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A37_RS02080	COG0723	plastoquinol--plastocyanin reductase activity
D4A37_RS02090	COG0765	amino acid transport
D4A37_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A37_RS02100	COG1126	abc transporter atp-binding protein
D4A37_RS02105	COG0840	transmembrane signaling receptor activity
D4A37_RS02115	COG0366	Alpha amylase catalytic
D4A37_RS02120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS02120	COG2190	(PTS) system
D4A37_RS02120	COG1263	PTS System
D4A37_RS02165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D4A37_RS02180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A37_RS02190	COG1116	anion transmembrane transporter activity
D4A37_RS02200	COG0488	(ABC) transporter
D4A37_RS02250	COG2270	Major facilitator Superfamily
D4A37_RS02275	COG4193	domain, Protein
D4A37_RS02285	COG2310	stress, protein
D4A37_RS02290	COG2310	stress, protein
D4A37_RS02295	COG2310	stress, protein
D4A37_RS02300	COG0861	Integral membrane protein TerC family
D4A37_RS02310	COG3853	Toxic anion resistance protein (TelA)
D4A37_RS02325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D4A37_RS02335	COG1295	ribonuclease BN
D4A37_RS02340	COG2217	Heavy metal translocating P-type atpase
D4A37_RS02345	COG0697	spore germination
D4A37_RS02370	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS02385	COG3871	stress protein (general stress protein 26)
D4A37_RS02390	COG0387	Pfam Sodium calcium exchanger
D4A37_RS02400	COG0535	radical SAM domain protein
D4A37_RS02420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D4A37_RS02440	COG3829	transcription factor binding
D4A37_RS02450	COG0833	amino acid
D4A37_RS02455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D4A37_RS02480	COG1263	PTS System
D4A37_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS02485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D4A37_RS02510	COG0463	Glycosyl transferase, family 2
D4A37_RS02520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A37_RS02520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D4A37_RS02525	COG0463	Glycosyl transferase, family 2
D4A37_RS02535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D4A37_RS02555	COG1228	amidohydrolase
D4A37_RS02560	COG1090	epimerase
D4A37_RS02590	COG1988	membrane-bound metal-dependent
D4A37_RS02595	COG1194	a g-specific adenine glycosylase
D4A37_RS02620	COG1132	(ABC) transporter
D4A37_RS02625	COG4129	membrane
D4A37_RS02630	COG0067	glutamate synthase
D4A37_RS02630	COG0069	glutamate synthase activity
D4A37_RS02630	COG0070	glutamate synthase
D4A37_RS02640	COG4555	ABC transporter
D4A37_RS02660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D4A37_RS02665	COG0735	belongs to the Fur family
D4A37_RS02780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D4A37_RS02785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D4A37_RS02795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D4A37_RS02805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D4A37_RS02810	COG5001	Diguanylate cyclase
D4A37_RS02810	COG1716	ATPase activity
D4A37_RS02815	COG2766	serine protein kinase
D4A37_RS02835	COG1585	Membrane protein implicated in regulation of membrane protease activity
D4A37_RS02840	COG2268	Band 7 protein
D4A37_RS02850	COG3290	protein histidine kinase activity
D4A37_RS02855	COG4565	transcriptional regulatory protein
D4A37_RS02860	COG2851	Citrate transporter
D4A37_RS02880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D4A37_RS02885	COG0745	RESPONSE REGULATOR receiver
D4A37_RS02890	COG5002	protein histidine kinase activity
D4A37_RS02900	COG4990	cell redox homeostasis
D4A37_RS02910	COG3290	protein histidine kinase activity
D4A37_RS02915	COG4565	transcriptional regulatory protein
D4A37_RS02920	COG3493	citrate carrier protein
D4A37_RS02925	COG0281	malic enzyme
D4A37_RS02935	COG0697	spore germination
D4A37_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS02950	COG5002	protein histidine kinase activity
D4A37_RS02955	COG0745	RESPONSE REGULATOR receiver
D4A37_RS02960	COG0454	-acetyltransferase
D4A37_RS02960	COG0456	acetyltransferase
D4A37_RS02965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D4A37_RS02970	COG3383	formate dehydrogenase (NAD+) activity
D4A37_RS02975	COG2427	Protein of unknown function (DUF1641)
D4A37_RS02990	COG0531	amino acid
D4A37_RS02995	COG0640	Transcriptional regulator
D4A37_RS03000	COG2217	Heavy metal translocating P-type atpase
D4A37_RS03005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D4A37_RS03020	COG3227	Zinc metalloprotease (Elastase)
D4A37_RS03040	COG2720	vancomycin resistance protein
D4A37_RS03045	COG1316	TRANSCRIPTIONal
D4A37_RS03050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS03055	COG0346	lactoylglutathione lyase activity
D4A37_RS03060	COG1253	flavin adenine dinucleotide binding
D4A37_RS03065	COG1027	Aspartate ammonia-lyase
D4A37_RS03070	COG1620	l-lactate permease
D4A37_RS03085	COG3104	oligopeptide transport
D4A37_RS03090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS03110	COG2226	methyltransferase
D4A37_RS03115	COG0156	8-amino-7-oxononanoate synthase activity
D4A37_RS03120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A37_RS03125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D4A37_RS03135	COG4548	von Willebrand factor, type A
D4A37_RS03140	COG0714	Associated with various cellular activities
D4A37_RS03145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A37_RS03160	COG0531	amino acid
D4A37_RS03165	COG2188	Transcriptional regulator
D4A37_RS03170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS03170	COG1263	PTS System
D4A37_RS03175	COG0366	Alpha amylase catalytic
D4A37_RS03190	COG0697	spore germination
D4A37_RS03195	COG4585	Histidine kinase
D4A37_RS03200	COG2197	response regulator
D4A37_RS03205	COG1404	Belongs to the peptidase S8 family
D4A37_RS03220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D4A37_RS03225	COG1115	amino acid carrier protein
D4A37_RS03230	COG1126	abc transporter atp-binding protein
D4A37_RS03235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A37_RS03240	COG0765	amino acid transport
D4A37_RS03245	COG0765	amino acid transport
D4A37_RS03250	COG0833	amino acid
D4A37_RS03265	COG1595	DNA-templated transcription, initiation
D4A37_RS03275	COG2378	regulation of single-species biofilm formation
D4A37_RS03280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D4A37_RS03290	COG5002	protein histidine kinase activity
D4A37_RS03305	COG0659	secondary active sulfate transmembrane transporter activity
D4A37_RS03330	COG0601	transmembrane transport
D4A37_RS03335	COG4608	Belongs to the ABC transporter superfamily
D4A37_RS03345	COG2271	Major facilitator Superfamily
D4A37_RS03350	COG1846	Transcriptional regulator
D4A37_RS03355	COG0477	Major facilitator Superfamily
D4A37_RS03360	COG1609	Transcriptional regulator
D4A37_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A37_RS03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A37_RS03385	COG1879	ABC-type sugar transport system periplasmic component
D4A37_RS03405	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS03415	COG1063	alcohol dehydrogenase
D4A37_RS03430	COG3568	Endonuclease Exonuclease Phosphatase
D4A37_RS03460	COG0840	transmembrane signaling receptor activity
D4A37_RS03465	COG3584	3D domain protein
D4A37_RS03465	COG1388	LysM domain
D4A37_RS03470	COG1476	TRANSCRIPTIONal
D4A37_RS03490	COG3104	oligopeptide transport
D4A37_RS03495	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS03510	COG1113	amino acid transport
D4A37_RS03515	COG2252	PERMEase
D4A37_RS03530	COG2153	protein acetylation
D4A37_RS03540	COG0475	glutathione-regulated potassium exporter activity
D4A37_RS03540	COG0569	domain protein
D4A37_RS03550	COG1845	cytochrome c oxidase, subunit III
D4A37_RS03555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D4A37_RS03560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D4A37_RS03565	COG0833	amino acid
D4A37_RS03570	COG4990	cell redox homeostasis
D4A37_RS03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4A37_RS03590	COG0697	spore germination
D4A37_RS03595	COG0531	amino acid
D4A37_RS03605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D4A37_RS03610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D4A37_RS03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D4A37_RS03615	COG1918	ferrous iron import across plasma membrane
D4A37_RS03620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D4A37_RS03625	COG0573	inorganic phosphate transmembrane transporter activity
D4A37_RS03630	COG0581	inorganic phosphate transmembrane transporter activity
D4A37_RS03760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D4A37_RS03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D4A37_RS03785	COG1116	anion transmembrane transporter activity
D4A37_RS03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A37_RS03795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A37_RS03800	COG0352	thiamine-phosphate diphosphorylase activity
D4A37_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A37_RS03810	COG2104	thiamine diphosphate biosynthetic process
D4A37_RS03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4A37_RS03825	COG0351	phosphomethylpyrimidine kinase
D4A37_RS03865	COG2205	protein histidine kinase activity
D4A37_RS03870	COG2814	Major facilitator Superfamily
D4A37_RS03875	COG1846	Transcriptional regulator
D4A37_RS03900	COG1136	(ABC) transporter
D4A37_RS03910	COG2252	PERMEase
D4A37_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS03975	COG0778	Nitroreductase
D4A37_RS03980	COG2719	SpoVR family
D4A37_RS04015	COG1937	Protein conserved in bacteria
D4A37_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A37_RS04020	COG0425	Belongs to the sulfur carrier protein TusA family
D4A37_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A37_RS04030	COG0425	Belongs to the sulfur carrier protein TusA family
D4A37_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A37_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
D4A37_RS04045	COG2210	Belongs to the sulfur carrier protein TusA family
D4A37_RS04050	COG0730	response to heat
D4A37_RS04060	COG1316	TRANSCRIPTIONal
D4A37_RS04065	COG0604	alcohol dehydrogenase
D4A37_RS04070	COG1283	sodium-dependent phosphate transmembrane transporter activity
D4A37_RS04090	COG3711	transcriptional antiterminator
D4A37_RS04090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A37_RS04095	COG1447	Phosphotransferase system cellobiose-specific component IIA
D4A37_RS04100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D4A37_RS04125	COG3584	3D domain protein
D4A37_RS04125	COG1388	LysM domain
D4A37_RS04130	COG0577	efflux transmembrane transporter activity
D4A37_RS04135	COG1136	(ABC) transporter
D4A37_RS04145	COG5522	Integral membrane protein (intg_mem_TP0381)
D4A37_RS04160	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS04165	COG3546	catalase activity
D4A37_RS04190	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS04220	COG0531	amino acid
D4A37_RS04225	COG0475	glutathione-regulated potassium exporter activity
D4A37_RS04235	COG1737	Transcriptional regulator
D4A37_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS04245	COG1263	PTS System
D4A37_RS04255	COG2259	Doxx family
D4A37_RS04270	COG0697	spore germination
D4A37_RS04275	COG1522	sequence-specific DNA binding
D4A37_RS04300	COG2076	Multidrug Resistance protein
D4A37_RS04305	COG1309	transcriptional regulator
D4A37_RS04310	COG2814	Major facilitator Superfamily
D4A37_RS04315	COG1733	regulation of RNA biosynthetic process
D4A37_RS04335	COG0693	protein deglycase activity
D4A37_RS04345	COG0531	amino acid
D4A37_RS04355	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS04360	COG1132	(ABC) transporter
D4A37_RS04365	COG1132	(ABC) transporter
D4A37_RS04375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A37_RS04380	COG0765	amino acid transport
D4A37_RS04385	COG1126	abc transporter atp-binding protein
D4A37_RS04400	COG0189	ligase activity
D4A37_RS04415	COG3679	Belongs to the UPF0342 family
D4A37_RS04430	COG0028	Belongs to the TPP enzyme family
D4A37_RS04435	COG3527	Alpha-acetolactate decarboxylase
D4A37_RS04450	COG0561	phosphatase activity
D4A37_RS04460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4A37_RS04465	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS04475	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS04485	COG4978	Transcriptional regulator
D4A37_RS04485	COG0789	Transcriptional regulator
D4A37_RS04495	COG0659	secondary active sulfate transmembrane transporter activity
D4A37_RS04500	COG1024	Enoyl-CoA hydratase
D4A37_RS04515	COG1363	Peptidase, m42
D4A37_RS04670	COG0601	transmembrane transport
D4A37_RS04675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A37_RS04680	COG0444	Belongs to the ABC transporter superfamily
D4A37_RS04685	COG4608	Belongs to the ABC transporter superfamily
D4A37_RS04690	COG0322	excinuclease ABC activity
D4A37_RS04755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS04790	COG2720	vancomycin resistance protein
D4A37_RS04795	COG2312	Erythromycin esterase
D4A37_RS04825	COG0477	Major facilitator Superfamily
D4A37_RS04830	COG3290	protein histidine kinase activity
D4A37_RS04835	COG4565	transcriptional regulatory protein
D4A37_RS04840	COG3181	Tripartite tricarboxylate transporter family receptor
D4A37_RS04950	COG0477	Major facilitator Superfamily
D4A37_RS05000	COG3711	transcriptional antiterminator
D4A37_RS05005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS05005	COG2190	(PTS) system
D4A37_RS05005	COG1263	PTS System
D4A37_RS05010	COG2723	6-phospho-beta-galactosidase activity
D4A37_RS05020	COG1183	phosphatidylcholine synthase activity
D4A37_RS05035	COG2814	Major facilitator Superfamily
D4A37_RS05040	COG0640	Transcriptional regulator
D4A37_RS05065	COG2376	Dihydroxyacetone kinase
D4A37_RS05080	COG2376	Dihydroxyacetone kinase
D4A37_RS05100	COG3437	response regulator, receiver
D4A37_RS05100	COG2770	Histidine kinase
D4A37_RS05170	COG0596	Alpha beta hydrolase
D4A37_RS05235	COG1191	sigma factor activity
D4A37_RS05245	COG2208	phosphoserine phosphatase activity
D4A37_RS05250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D4A37_RS05255	COG0784	Response regulator, receiver
D4A37_RS05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A37_RS05255	COG2205	protein histidine kinase activity
D4A37_RS05255	COG2198	Histidine kinase
D4A37_RS05285	COG4585	Histidine kinase
D4A37_RS05290	COG2197	response regulator
D4A37_RS05320	COG0420	3'-5' exonuclease activity
D4A37_RS05325	COG4717	serine-type aminopeptidase activity
D4A37_RS05375	COG1280	lysine exporter protein (LysE YggA)
D4A37_RS05380	COG0346	lactoylglutathione lyase activity
D4A37_RS05385	COG0346	lactoylglutathione lyase activity
D4A37_RS05390	COG2267	carboxylic ester hydrolase activity
D4A37_RS05415	COG3620	sequence-specific DNA binding
D4A37_RS05420	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D4A37_RS05425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D4A37_RS05435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D4A37_RS05445	COG1595	DNA-templated transcription, initiation
D4A37_RS05465	COG3973	AAA domain
D4A37_RS05470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4A37_RS05500	COG0537	adenosine 5'-monophosphoramidase activity
D4A37_RS05505	COG1131	(ABC) transporter
D4A37_RS05510	COG4473	ABC transporter
D4A37_RS05525	COG1309	transcriptional regulator
D4A37_RS05530	COG3402	PFAM membrane-flanked domain
D4A37_RS05535	COG3428	Bacterial PH domain
D4A37_RS05570	COG3402	PFAM membrane-flanked domain
D4A37_RS05575	COG3428	Bacterial PH domain
D4A37_RS05580	COG2329	Antibiotic biosynthesis monooxygenase
D4A37_RS05585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A37_RS05600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D4A37_RS05625	COG1309	transcriptional regulator
D4A37_RS05630	COG1511	domain protein
D4A37_RS05655	COG1609	Transcriptional regulator
D4A37_RS05665	COG1234	tRNA 3'-trailer cleavage
D4A37_RS05670	COG0095	Lipoate-protein ligase
D4A37_RS05680	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS05695	COG3209	COG3209 Rhs family protein
D4A37_RS05715	COG1408	metallophosphoesterase
D4A37_RS05720	COG1078	dGTPase activity
D4A37_RS05740	COG3708	Transcriptional regulator
D4A37_RS05740	COG2207	Transcriptional regulator
D4A37_RS05745	COG2205	protein histidine kinase activity
D4A37_RS05750	COG0745	RESPONSE REGULATOR receiver
D4A37_RS05785	COG0501	Belongs to the peptidase M48B family
D4A37_RS05790	COG0840	transmembrane signaling receptor activity
D4A37_RS05795	COG0697	spore germination
D4A37_RS05810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D4A37_RS05815	COG2224	Isocitrate lyase
D4A37_RS05825	COG1278	Cold shock
D4A37_RS05845	COG0398	Pfam SNARE associated Golgi protein
D4A37_RS05905	COG0179	Fumarylacetoacetate (FAA) hydrolase
D4A37_RS05930	COG0367	asparagine synthase
D4A37_RS05940	COG0753	catalase activity
D4A37_RS05950	COG0004	ammonium transporteR
D4A37_RS05980	COG2996	Protein conserved in bacteria
D4A37_RS05985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4A37_RS05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS06010	COG0561	phosphatase activity
D4A37_RS06030	COG2267	carboxylic ester hydrolase activity
D4A37_RS06045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS06050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D4A37_RS06055	COG5504	Zn-dependent protease
D4A37_RS06065	COG0180	Tryptophanyl-tRNA synthetase
D4A37_RS06080	COG4166	transmembrane transport
D4A37_RS06085	COG0601	transmembrane transport
D4A37_RS06090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A37_RS06095	COG0444	Belongs to the ABC transporter superfamily
D4A37_RS06100	COG4608	Belongs to the ABC transporter superfamily
D4A37_RS06105	COG0534	Mate efflux family protein
D4A37_RS06110	COG4166	transmembrane transport
D4A37_RS06125	COG0861	Integral membrane protein TerC family
D4A37_RS06130	COG4862	establishment of competence for transformation
D4A37_RS06135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A37_RS06145	COG1164	Oligoendopeptidase f
D4A37_RS06160	COG2346	COG2346, Truncated hemoglobins
D4A37_RS06165	COG4116	CYTH
D4A37_RS06175	COG2357	RelA SpoT domain protein
D4A37_RS06185	COG0564	pseudouridine synthase activity
D4A37_RS06200	COG0772	Belongs to the SEDS family
D4A37_RS06205	COG1216	Glycosyl transferase, family 2
D4A37_RS06215	COG4122	O-methyltransferase activity
D4A37_RS06225	COG0457	Tetratricopeptide repeat
D4A37_RS06225	COG0463	Glycosyl transferase, family 2
D4A37_RS06245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D4A37_RS06260	COG1091	dTDP-4-dehydrorhamnose reductase activity
D4A37_RS06300	COG0210	DNA helicase
D4A37_RS06305	COG2153	protein acetylation
D4A37_RS06315	COG2382	esterase
D4A37_RS06330	COG5492	domain, Protein
D4A37_RS06335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4A37_RS06345	COG0512	Glutamine amidotransferase of anthranilate synthase
D4A37_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D4A37_RS06365	COG0133	tryptophan synthase activity
D4A37_RS06380	COG1620	l-lactate permease
D4A37_RS06385	COG5634	Uncharacterized conserved protein (DUF2278)
D4A37_RS06445	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A37_RS06455	COG1476	TRANSCRIPTIONal
D4A37_RS06480	COG4956	integral membrane protein (PIN domain superfamily)
D4A37_RS06510	COG1686	Belongs to the peptidase S11 family
D4A37_RS06515	COG0681	Belongs to the peptidase S26 family
D4A37_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS06560	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A37_RS06565	COG1177	transmembrane transport
D4A37_RS06570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D4A37_RS06580	COG2409	Drug exporters of the RND superfamily
D4A37_RS06590	COG0564	pseudouridine synthase activity
D4A37_RS06600	COG2340	Cysteine-rich secretory protein family
D4A37_RS06605	COG0247	lactate metabolic process
D4A37_RS06610	COG0277	FAD linked oxidase domain protein
D4A37_RS06615	COG3835	regulator
D4A37_RS06625	COG0745	RESPONSE REGULATOR receiver
D4A37_RS06630	COG5002	protein histidine kinase activity
D4A37_RS06635	COG2186	Transcriptional regulator
D4A37_RS06650	COG1556	Lactate utilization protein
D4A37_RS06655	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D4A37_RS06665	COG2116	formate transmembrane transporter activity
D4A37_RS06670	COG0861	Integral membrane protein TerC family
D4A37_RS06675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D4A37_RS06685	COG2030	dehydratase
D4A37_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS06710	COG3243	poly(R)-hydroxyalkanoic acid synthase
D4A37_RS06720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D4A37_RS06735	COG1840	ABC-type Fe3 transport system, periplasmic component
D4A37_RS06740	COG3842	ATPase activity
D4A37_RS06765	COG1349	DNA-binding transcription factor activity
D4A37_RS06775	COG0235	Class ii aldolase
D4A37_RS06785	COG2861	carbohydrate metabolic process
D4A37_RS06795	COG3852	Histidine kinase
D4A37_RS06800	COG1846	Transcriptional regulator
D4A37_RS06810	COG2318	DinB family
D4A37_RS06815	COG5002	protein histidine kinase activity
D4A37_RS06825	COG0720	synthase
D4A37_RS06840	COG4873	Protein conserved in bacteria
D4A37_RS06870	COG1780	Probably involved in ribonucleotide reductase function
D4A37_RS06890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4A37_RS06895	COG1725	Transcriptional regulator
D4A37_RS06900	COG1131	(ABC) transporter
D4A37_RS06910	COG1131	(ABC) transporter
D4A37_RS06915	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D4A37_RS06920	COG1266	CAAX protease self-immunity
D4A37_RS06930	COG1522	sequence-specific DNA binding
D4A37_RS06940	COG1335	isochorismatase
D4A37_RS06950	COG1619	proteins homologs of microcin C7 resistance protein MccF
D4A37_RS06955	COG2070	2-Nitropropane dioxygenase
D4A37_RS06960	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D4A37_RS06970	COG1696	Membrane protein involved in D-alanine export
D4A37_RS06990	COG0716	FMN binding
D4A37_RS07035	COG1846	Transcriptional regulator
D4A37_RS07045	COG1301	dicarboxylic acid transport
D4A37_RS07050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D4A37_RS07055	COG4709	membrane
D4A37_RS07060	COG3874	Sporulation protein YtfJ
D4A37_RS07080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A37_RS07085	COG0028	Belongs to the TPP enzyme family
D4A37_RS07090	COG0440	acetolactate synthase activity
D4A37_RS07165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D4A37_RS07180	COG1183	phosphatidylcholine synthase activity
D4A37_RS07185	COG1368	sulfuric ester hydrolase activity
D4A37_RS07195	COG0019	diaminopimelate decarboxylase activity
D4A37_RS07215	COG0529	Catalyzes the synthesis of activated sulfate
D4A37_RS07220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D4A37_RS07240	COG1648	precorrin-2 dehydrogenase activity
D4A37_RS07245	COG0733	neurotransmitter:sodium symporter activity
D4A37_RS07265	COG1757	Na H antiporter
D4A37_RS07280	COG4758	membrane
D4A37_RS07285	COG4585	Histidine kinase
D4A37_RS07290	COG2197	response regulator
D4A37_RS07300	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS07310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D4A37_RS07350	COG0730	response to heat
D4A37_RS07355	COG0306	phosphate transporter
D4A37_RS07360	COG1392	Phosphate transport regulator
D4A37_RS07365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A37_RS07380	COG3852	Histidine kinase
D4A37_RS07385	COG1801	Protein of unknown function DUF72
D4A37_RS07395	COG0582	viral genome integration into host DNA
D4A37_RS07400	COG5002	protein histidine kinase activity
D4A37_RS07415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D4A37_RS07415	COG0392	lysyltransferase activity
D4A37_RS07430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D4A37_RS07435	COG1686	Belongs to the peptidase S11 family
D4A37_RS07440	COG2715	membrane protein required for spore maturation
D4A37_RS07445	COG0700	Nucleoside recognition
D4A37_RS07450	COG1187	pseudouridine synthase activity
D4A37_RS07460	COG1333	cytochrome c biogenesis protein
D4A37_RS07465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4A37_RS07470	COG0745	RESPONSE REGULATOR receiver
D4A37_RS07475	COG5002	protein histidine kinase activity
D4A37_RS07480	COG2096	Adenosyltransferase
D4A37_RS07485	COG4942	peptidase
D4A37_RS07495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D4A37_RS07500	COG1141	Ferredoxin
D4A37_RS07510	COG0514	ATP-dependent DNA helicase (RecQ)
D4A37_RS07515	COG1266	CAAX protease self-immunity
D4A37_RS07525	COG1408	metallophosphoesterase
D4A37_RS07535	COG4862	establishment of competence for transformation
D4A37_RS07540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D4A37_RS07560	COG0492	ferredoxin-NADP+ reductase activity
D4A37_RS07565	COG0252	asparaginase activity
D4A37_RS07605	COG1160	GTP binding
D4A37_RS07630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D4A37_RS07645	COG0142	geranyltranstransferase activity
D4A37_RS07655	COG0142	geranyltranstransferase activity
D4A37_RS07680	COG0457	Tetratricopeptide repeat
D4A37_RS07700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D4A37_RS07705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D4A37_RS07705	COG2010	Cytochrome c
D4A37_RS07710	COG4347	Protein of unknown function (DUF1405)
D4A37_RS07725	COG2738	Putative neutral zinc metallopeptidase
D4A37_RS07735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS07745	COG1694	Mazg nucleotide pyrophosphohydrolase
D4A37_RS07765	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS07800	COG1199	ATP-dependent helicase activity
D4A37_RS07800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D4A37_RS07820	COG3935	DnaD domain protein
D4A37_RS07825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D4A37_RS07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A37_RS07835	COG4499	WXG100 protein secretion system (Wss), protein YukC
D4A37_RS07890	COG0116	Belongs to the methyltransferase superfamily
D4A37_RS07900	COG1199	ATP-dependent helicase activity
D4A37_RS07905	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D4A37_RS07915	COG0024	Methionine aminopeptidase
D4A37_RS07930	COG2233	PERMEase
D4A37_RS07935	COG2311	Membrane
D4A37_RS07940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D4A37_RS07950	COG0456	acetyltransferase
D4A37_RS07985	COG0754	glutathionylspermidine amidase activity
D4A37_RS08000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A37_RS08015	COG0454	-acetyltransferase
D4A37_RS08035	COG0328	RNA-DNA hybrid ribonuclease activity
D4A37_RS08070	COG3403	YqcI/YcgG family
D4A37_RS08075	COG1280	lysine exporter protein (LysE YggA)
D4A37_RS08090	COG3162	membrane
D4A37_RS08095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4A37_RS08100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4A37_RS08110	COG0475	glutathione-regulated potassium exporter activity
D4A37_RS08120	COG0789	Transcriptional regulator
D4A37_RS08120	COG4978	Transcriptional regulator
D4A37_RS08130	COG2323	membrane
D4A37_RS08135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D4A37_RS08170	COG2814	Major facilitator Superfamily
D4A37_RS08190	COG1923	regulation of RNA biosynthetic process
D4A37_RS08200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D4A37_RS08205	COG1360	Flagellar Motor Protein
D4A37_RS08210	COG2201	protein-glutamate methylesterase activity
D4A37_RS08215	COG0643	Histidine kinase
D4A37_RS08215	COG2198	Histidine kinase
D4A37_RS08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A37_RS08220	COG1776	CheC inhibitor of MCP methylation
D4A37_RS08235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D4A37_RS08255	COG1256	bacterial-type flagellum assembly
D4A37_RS08260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A37_RS08280	COG1815	bacterial-type flagellum-dependent cell motility
D4A37_RS08285	COG1558	bacterial-type flagellum-dependent cell motility
D4A37_RS08295	COG1766	The M ring may be actively involved in energy transduction
D4A37_RS08300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A37_RS08310	COG1157	protein secretion by the type III secretion system
D4A37_RS08330	COG1749	Flagellar hook protein flgE
D4A37_RS08345	COG0835	chemotaxis
D4A37_RS08345	COG0784	Response regulator, receiver
D4A37_RS08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A37_RS08360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A37_RS08365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A37_RS08370	COG0741	lytic transglycosylase activity
D4A37_RS08380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A37_RS08385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A37_RS08385	COG1776	CheC inhibitor of MCP methylation
D4A37_RS08395	COG1338	Plays a role in the flagellum-specific transport system
D4A37_RS08400	COG1987	bacterial-type flagellum assembly
D4A37_RS08410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4A37_RS08415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4A37_RS08420	COG1419	protein localization to endoplasmic reticulum
D4A37_RS08425	COG4786	Flagellar basal body rod
D4A37_RS08430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D4A37_RS08465	COG2329	Antibiotic biosynthesis monooxygenase
D4A37_RS08485	COG3764	Sortase (surface protein transpeptidase)
D4A37_RS08490	COG3764	Sortase (surface protein transpeptidase)
D4A37_RS08515	COG0583	DNA-binding transcription factor activity
D4A37_RS08520	COG3842	ATPase activity
D4A37_RS08565	COG1686	Belongs to the peptidase S11 family
D4A37_RS08575	COG0406	alpha-ribazole phosphatase activity
D4A37_RS08605	COG0367	asparagine synthase
D4A37_RS08635	COG1802	Transcriptional regulator
D4A37_RS08640	COG0697	spore germination
D4A37_RS08645	COG1216	Glycosyl transferase, family 2
D4A37_RS08645	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS08650	COG1757	Na H antiporter
D4A37_RS08655	COG0114	fumarate hydratase activity
D4A37_RS08675	COG0534	Mate efflux family protein
D4A37_RS08680	COG3340	Belongs to the peptidase S51 family
D4A37_RS08700	COG0785	Cytochrome C biogenesis protein
D4A37_RS08725	COG2733	membrane
D4A37_RS08765	COG1131	(ABC) transporter
D4A37_RS08780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A37_RS08810	COG0528	UMP kinase activity
D4A37_RS08820	COG1027	Aspartate ammonia-lyase
D4A37_RS08825	COG0281	malic enzyme
D4A37_RS08830	COG4191	Histidine kinase
D4A37_RS08835	COG0784	Response regulator, receiver
D4A37_RS08840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D4A37_RS08855	COG3620	sequence-specific DNA binding
D4A37_RS08890	COG1051	belongs to the nudix hydrolase family
D4A37_RS08895	COG2814	Major facilitator Superfamily
D4A37_RS08910	COG3842	ATPase activity
D4A37_RS08915	COG2508	Transcriptional regulator
D4A37_RS08930	COG0395	ABC-type sugar transport system, permease component
D4A37_RS08940	COG2188	Transcriptional regulator
D4A37_RS08945	COG2222	sugar isomerase
D4A37_RS08960	COG1105	Belongs to the carbohydrate kinase PfkB family
D4A37_RS08975	COG0477	Major facilitator Superfamily
D4A37_RS08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D4A37_RS08995	COG4166	transmembrane transport
D4A37_RS09000	COG2223	nitrite transmembrane transporter activity
D4A37_RS09005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4A37_RS09020	COG2244	polysaccharide biosynthetic process
D4A37_RS09025	COG0733	neurotransmitter:sodium symporter activity
D4A37_RS09035	COG5566	PFAM Mor transcription activator
D4A37_RS09040	COG2323	membrane
D4A37_RS09060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4A37_RS09065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A37_RS09070	COG0028	Belongs to the TPP enzyme family
D4A37_RS09090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D4A37_RS09115	COG2814	Major facilitator Superfamily
D4A37_RS09120	COG3384	dioxygenase
D4A37_RS09140	COG3279	Response regulator of the LytR AlgR family
D4A37_RS09145	COG0427	acetyl-CoA hydrolase
D4A37_RS09160	COG1073	alpha beta
D4A37_RS09165	COG4166	transmembrane transport
D4A37_RS09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS09200	COG0745	RESPONSE REGULATOR receiver
D4A37_RS09215	COG1914	H( )-stimulated, divalent metal cation uptake system
D4A37_RS09230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D4A37_RS09235	COG0531	amino acid
D4A37_RS09270	COG0714	Associated with various cellular activities
D4A37_RS09280	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D4A37_RS09320	COG2390	Transcriptional regulator
D4A37_RS09330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS09335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D4A37_RS09350	COG4846	Membrane protein involved in cytochrome C biogenesis
D4A37_RS09370	COG0583	DNA-binding transcription factor activity
D4A37_RS09385	COG0006	proline dipeptidase activity
D4A37_RS09390	COG2132	Multicopper oxidase
D4A37_RS09400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4A37_RS09410	COG1309	transcriptional regulator
D4A37_RS09415	COG1131	(ABC) transporter
D4A37_RS09475	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS09490	COG2372	response to copper ion
D4A37_RS09490	COG1276	copper resistance
D4A37_RS09495	COG4549	nuclear export factor GLE1
D4A37_RS09500	COG0697	spore germination
D4A37_RS09505	COG0583	DNA-binding transcription factor activity
D4A37_RS09510	COG1959	2 iron, 2 sulfur cluster binding
D4A37_RS09515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D4A37_RS09520	COG0778	Nitroreductase
D4A37_RS09530	COG0154	amidase activity
D4A37_RS09535	COG0628	permease
D4A37_RS09545	COG1231	oxidoreductase activity
D4A37_RS09550	COG0523	cobalamin synthesis protein
D4A37_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS09565	COG2030	dehydratase
D4A37_RS09570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS09580	COG0411	ABC transporter
D4A37_RS09600	COG0583	DNA-binding transcription factor activity
D4A37_RS09625	COG1271	oxidase subunit
D4A37_RS09630	COG1294	oxidase, subunit
D4A37_RS09635	COG4988	ABC transporter
D4A37_RS09640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D4A37_RS09650	COG1216	Glycosyl transferase, family 2
D4A37_RS09680	COG1686	Belongs to the peptidase S11 family
D4A37_RS09695	COG0791	NLP P60 protein
D4A37_RS09695	COG1388	LysM domain
D4A37_RS09705	COG1132	(ABC) transporter
D4A37_RS09710	COG0745	RESPONSE REGULATOR receiver
D4A37_RS09715	COG5002	protein histidine kinase activity
D4A37_RS09725	COG0300	oxidoreductase activity
D4A37_RS09730	COG4122	O-methyltransferase activity
D4A37_RS09755	COG0460	homoserine dehydrogenase
D4A37_RS09780	COG1316	TRANSCRIPTIONal
D4A37_RS09795	COG0745	RESPONSE REGULATOR receiver
D4A37_RS09800	COG5002	protein histidine kinase activity
D4A37_RS09815	COG1285	pathogenesis
D4A37_RS09820	COG1247	-acetyltransferase
D4A37_RS09840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D4A37_RS09850	COG1082	Xylose isomerase domain protein TIM barrel
D4A37_RS09860	COG2814	Major facilitator Superfamily
D4A37_RS09865	COG1279	arginine transmembrane transporter activity
D4A37_RS09870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS09880	COG1752	Esterase of the alpha-beta hydrolase superfamily
D4A37_RS09915	COG0577	efflux transmembrane transporter activity
D4A37_RS09920	COG2002	toxin-antitoxin pair type II binding
D4A37_RS09925	COG1404	Belongs to the peptidase S8 family
D4A37_RS09935	COG0640	Transcriptional regulator
D4A37_RS09940	COG0667	Aldo Keto reductase
D4A37_RS09945	COG2814	Major facilitator Superfamily
D4A37_RS09950	COG3152	Membrane
D4A37_RS09975	COG0840	transmembrane signaling receptor activity
D4A37_RS09990	COG3949	Membrane
D4A37_RS09995	COG0783	Belongs to the Dps family
D4A37_RS10010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D4A37_RS10020	COG1231	oxidoreductase activity
D4A37_RS10025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS10030	COG4989	oxidoreductase activity
D4A37_RS10035	COG0523	cobalamin synthesis protein
D4A37_RS10040	COG0456	acetyltransferase
D4A37_RS10045	COG0803	Belongs to the bacterial solute-binding protein 9 family
D4A37_RS10045	COG3443	Belongs to the bacterial solute-binding protein 9 family
D4A37_RS10060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D4A37_RS10070	COG4166	transmembrane transport
D4A37_RS10085	COG0406	alpha-ribazole phosphatase activity
D4A37_RS10095	COG5337	Spore coat protein CotH
D4A37_RS10100	COG1051	belongs to the nudix hydrolase family
D4A37_RS10105	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS10110	COG2244	polysaccharide biosynthetic process
D4A37_RS10120	COG0701	Predicted permease
D4A37_RS10125	COG3689	TIGRFAM TIGR03943 family protein
D4A37_RS10130	COG1607	acyl-coa hydrolase
D4A37_RS10140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A37_RS10155	COG0702	epimerase
D4A37_RS10160	COG2839	Protein conserved in bacteria
D4A37_RS10165	COG1253	flavin adenine dinucleotide binding
D4A37_RS10180	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS10185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4A37_RS10205	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS10215	COG1876	peptidase activity
D4A37_RS10230	COG2211	Major facilitator Superfamily
D4A37_RS10250	COG0561	phosphatase activity
D4A37_RS10255	COG1846	Transcriptional regulator
D4A37_RS10260	COG2814	Major facilitator Superfamily
D4A37_RS10270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D4A37_RS10275	COG4106	trans-aconitate 2-methyltransferase activity
D4A37_RS10290	COG1819	glycosyl
D4A37_RS10295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS10300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS10320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS10330	COG0456	acetyltransferase
D4A37_RS10370	COG4499	WXG100 protein secretion system (Wss), protein YukC
D4A37_RS10470	COG4824	toxin secretion phage lysis holin
D4A37_RS10495	COG3874	Sporulation protein YtfJ
D4A37_RS10520	COG2226	methyltransferase
D4A37_RS10540	COG1082	Xylose isomerase domain protein TIM barrel
D4A37_RS10545	COG0346	lactoylglutathione lyase activity
D4A37_RS10555	COG0604	alcohol dehydrogenase
D4A37_RS10560	COG1595	DNA-templated transcription, initiation
D4A37_RS10580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D4A37_RS10580	COG0426	domain, Protein
D4A37_RS10590	COG0386	Belongs to the glutathione peroxidase family
D4A37_RS10595	COG1305	Transglutaminase-like
D4A37_RS10600	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D4A37_RS10605	COG0714	Associated with various cellular activities
D4A37_RS10620	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D4A37_RS10625	COG1140	nitrate reductase beta subunit
D4A37_RS10630	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D4A37_RS10635	COG2181	nitrate reductase activity
D4A37_RS10645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D4A37_RS10650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D4A37_RS10655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4A37_RS10660	COG0303	'Molybdopterin
D4A37_RS10665	COG0314	molybdopterin synthase activity
D4A37_RS10675	COG2223	nitrite transmembrane transporter activity
D4A37_RS10695	COG1648	precorrin-2 dehydrogenase activity
D4A37_RS10705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D4A37_RS10705	COG1587	Uroporphyrinogen-III synthase
D4A37_RS10710	COG2146	nitrite reductase [NAD(P)H] activity
D4A37_RS10715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D4A37_RS10720	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D4A37_RS10750	COG2359	stage V sporulation protein S
D4A37_RS10805	COG1418	mRNA catabolic process
D4A37_RS10810	COG0488	(ABC) transporter
D4A37_RS10825	COG0629	single-stranded DNA binding
D4A37_RS10830	COG1413	lyase activity
D4A37_RS10845	COG2136	Putative SAM-dependent methyltransferase
D4A37_RS10845	COG2521	methyltransferase
D4A37_RS10850	COG0018	arginyl-trna synthetase
D4A37_RS10890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D4A37_RS10895	COG0017	Asparaginyl-tRNA synthetase
D4A37_RS10900	COG1929	Belongs to the glycerate kinase type-1 family
D4A37_RS10905	COG0471	metal ion transport
D4A37_RS10910	COG0745	RESPONSE REGULATOR receiver
D4A37_RS10915	COG5002	protein histidine kinase activity
D4A37_RS10915	COG3850	Histidine kinase
D4A37_RS10925	COG0733	neurotransmitter:sodium symporter activity
D4A37_RS10950	COG2610	gluconate transmembrane transporter activity
D4A37_RS10955	COG1454	alcohol dehydrogenase
D4A37_RS10960	COG1794	racemase activity, acting on amino acids and derivatives
D4A37_RS10970	COG0456	acetyltransferase
D4A37_RS10975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D4A37_RS10985	COG1131	(ABC) transporter
D4A37_RS10990	COG4473	ABC transporter
D4A37_RS11000	COG0546	phosphoglycolate phosphatase activity
D4A37_RS11035	COG0768	penicillin binding
D4A37_RS11045	COG0204	Acyl-transferase
D4A37_RS11050	COG1272	protein, Hemolysin III
D4A37_RS11060	COG0805	protein transport
D4A37_RS11070	COG1307	EDD domain protein, DegV family
D4A37_RS11075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D4A37_RS11080	COG1999	signal sequence binding
D4A37_RS11085	COG0071	Belongs to the small heat shock protein (HSP20) family
D4A37_RS11090	COG0367	asparagine synthase
D4A37_RS11105	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS11110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS11115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A37_RS11135	COG1335	isochorismatase
D4A37_RS11145	COG0668	transmembrane transport
D4A37_RS11150	COG2203	Gaf domain
D4A37_RS11150	COG4585	Histidine kinase
D4A37_RS11155	COG2197	response regulator
D4A37_RS11160	COG1737	Transcriptional regulator
D4A37_RS11165	COG1064	alcohol dehydrogenase
D4A37_RS11180	COG1070	Carbohydrate kinase
D4A37_RS11190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D4A37_RS11220	COG1174	glycine betaine transport
D4A37_RS11255	COG1253	flavin adenine dinucleotide binding
D4A37_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS11265	COG5506	Protein of unknown function (DUF1694)
D4A37_RS11280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4A37_RS11285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D4A37_RS11290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D4A37_RS11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D4A37_RS11300	COG0456	acetyltransferase
D4A37_RS11305	COG3829	transcription factor binding
D4A37_RS11310	COG1509	lysine 2,3-aminomutase activity
D4A37_RS11345	COG4991	sh3 domain protein
D4A37_RS11345	COG0515	serine threonine protein kinase
D4A37_RS11345	COG3064	Membrane
D4A37_RS11350	COG4326	sporulation control protein
D4A37_RS11355	COG0671	phosphoesterase, PA-phosphatase related
D4A37_RS11360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D4A37_RS11370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A37_RS11415	COG1595	DNA-templated transcription, initiation
D4A37_RS11455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4A37_RS11485	COG0300	oxidoreductase activity
D4A37_RS11505	COG4499	WXG100 protein secretion system (Wss), protein YukC
D4A37_RS11505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A37_RS11515	COG2814	Major facilitator Superfamily
D4A37_RS11525	COG0372	Belongs to the citrate synthase family
D4A37_RS11530	COG2079	MmgE PrpD family protein
D4A37_RS11535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D4A37_RS11540	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS11545	COG2084	Dehydrogenase
D4A37_RS11555	COG1280	lysine exporter protein (LysE YggA)
D4A37_RS11560	COG1024	Enoyl-CoA hydratase
D4A37_RS11575	COG0420	3'-5' exonuclease activity
D4A37_RS11580	COG0419	ATPase involved in DNA repair
D4A37_RS11600	COG2223	nitrite transmembrane transporter activity
D4A37_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS11610	COG1169	isochorismate synthase
D4A37_RS11615	COG1021	2,3-dihydroxybenzoate-AMP ligase
D4A37_RS11620	COG1535	isochorismatase
D4A37_RS11620	COG3433	isochorismatase activity
D4A37_RS11625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D4A37_RS11630	COG3251	PFAM MbtH domain protein
D4A37_RS11635	COG2814	Major facilitator Superfamily
D4A37_RS11650	COG0776	regulation of translation
D4A37_RS11660	COG2318	DinB family
D4A37_RS11670	COG1115	amino acid carrier protein
D4A37_RS11685	COG1187	pseudouridine synthase activity
D4A37_RS11690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D4A37_RS11700	COG1136	(ABC) transporter
D4A37_RS11710	COG0596	Alpha beta hydrolase
D4A37_RS11725	COG0028	Belongs to the TPP enzyme family
D4A37_RS11735	COG2226	methyltransferase
D4A37_RS11745	COG1234	tRNA 3'-trailer cleavage
D4A37_RS11775	COG2207	Transcriptional regulator
D4A37_RS11800	COG2755	lipolytic protein G-D-S-L family
D4A37_RS11800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D4A37_RS11810	COG5002	protein histidine kinase activity
D4A37_RS11820	COG0745	RESPONSE REGULATOR receiver
D4A37_RS11825	COG5002	protein histidine kinase activity
D4A37_RS11840	COG1846	Transcriptional regulator
D4A37_RS11880	COG1247	-acetyltransferase
D4A37_RS11905	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D4A37_RS11910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D4A37_RS11920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS11955	COG0010	Belongs to the arginase family
D4A37_RS11965	COG0583	DNA-binding transcription factor activity
D4A37_RS11970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D4A37_RS11985	COG0583	DNA-binding transcription factor activity
D4A37_RS11990	COG2258	MOSC domain
D4A37_RS12005	COG1132	(ABC) transporter
D4A37_RS12010	COG1132	(ABC) transporter
D4A37_RS12045	COG1396	sequence-specific DNA binding
D4A37_RS12085	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
D4A37_RS12090	COG1595	DNA-templated transcription, initiation
D4A37_RS12095	COG4122	O-methyltransferase activity
D4A37_RS12110	COG1649	PFAM Uncharacterised BCR, COG1649
D4A37_RS12130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D4A37_RS12135	COG2971	BadF BadG BcrA BcrD
D4A37_RS12155	COG1846	Transcriptional regulator
D4A37_RS12170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS12235	COG1309	transcriptional regulator
D4A37_RS12250	COG1136	(ABC) transporter
D4A37_RS12250	COG0577	efflux transmembrane transporter activity
D4A37_RS12255	COG0500	methyltransferase
D4A37_RS12255	COG3615	Tellurite resistance protein tehB
D4A37_RS12265	COG3961	Belongs to the TPP enzyme family
D4A37_RS12290	COG2195	Cleaves the N-terminal amino acid of tripeptides
D4A37_RS12300	COG0110	maltose O-acetyltransferase activity
D4A37_RS12310	COG1136	(ABC) transporter
D4A37_RS12360	COG1752	Esterase of the alpha-beta hydrolase superfamily
D4A37_RS12375	COG1760	l-serine dehydratase
D4A37_RS12380	COG1760	l-serine dehydratase
D4A37_RS12385	COG0814	amino acid
D4A37_RS12405	COG1533	DNA photolyase activity
D4A37_RS12410	COG0076	glutamate decarboxylase activity
D4A37_RS12420	COG0745	RESPONSE REGULATOR receiver
D4A37_RS12425	COG2205	protein histidine kinase activity
D4A37_RS12430	COG1136	(ABC) transporter
D4A37_RS12435	COG0577	efflux transmembrane transporter activity
D4A37_RS12445	COG0768	penicillin binding
D4A37_RS12450	COG1595	DNA-templated transcription, initiation
D4A37_RS12465	COG0768	penicillin binding
D4A37_RS12515	COG0697	spore germination
D4A37_RS12525	COG3397	chitin binding
D4A37_RS12530	COG0823	Involved in the tonB-independent uptake of proteins
D4A37_RS12540	COG1609	Transcriptional regulator
D4A37_RS12545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D4A37_RS12550	COG0561	phosphatase activity
D4A37_RS12555	COG0673	inositol 2-dehydrogenase activity
D4A37_RS12560	COG0738	Major facilitator superfamily
D4A37_RS12585	COG1252	NADH dehydrogenase
D4A37_RS12590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS12605	COG1131	(ABC) transporter
D4A37_RS12615	COG1309	transcriptional regulator
D4A37_RS12635	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS12640	COG0439	Biotin carboxylase
D4A37_RS12645	COG0511	ligase activity, forming carbon-carbon bonds
D4A37_RS12650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D4A37_RS12655	COG1024	Enoyl-CoA hydratase
D4A37_RS12660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D4A37_RS12665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A37_RS12720	COG0572	uridine kinase
D4A37_RS12730	COG2318	DinB family
D4A37_RS12735	COG1686	Belongs to the peptidase S11 family
D4A37_RS12760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D4A37_RS12790	COG2207	Transcriptional regulator
D4A37_RS12820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D4A37_RS12835	COG2814	Major facilitator Superfamily
D4A37_RS12840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D4A37_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS12855	COG1733	regulation of RNA biosynthetic process
D4A37_RS12865	COG2226	methyltransferase
D4A37_RS12875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D4A37_RS12885	COG1942	4-Oxalocrotonate Tautomerase
D4A37_RS12890	COG0583	DNA-binding transcription factor activity
D4A37_RS12915	COG0697	spore germination
D4A37_RS12920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS12940	COG1063	alcohol dehydrogenase
D4A37_RS12950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D4A37_RS12965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D4A37_RS12970	COG0693	protein deglycase activity
D4A37_RS12985	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D4A37_RS12990	COG3773	Cell wall hydrolase
D4A37_RS13000	COG0745	RESPONSE REGULATOR receiver
D4A37_RS13005	COG2205	protein histidine kinase activity
D4A37_RS13015	COG0583	DNA-binding transcription factor activity
D4A37_RS13020	COG0667	Aldo Keto reductase
D4A37_RS13025	COG0488	(ABC) transporter
D4A37_RS13040	COG1136	(ABC) transporter
D4A37_RS13045	COG0577	efflux transmembrane transporter activity
D4A37_RS13065	COG0460	homoserine dehydrogenase
D4A37_RS13070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS13080	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D4A37_RS13130	COG2124	cytochrome p450
D4A37_RS13170	COG0561	phosphatase activity
D4A37_RS13175	COG5002	protein histidine kinase activity
D4A37_RS13180	COG0768	penicillin binding
D4A37_RS13185	COG1819	glycosyl
D4A37_RS13190	COG1794	racemase activity, acting on amino acids and derivatives
D4A37_RS13215	COG2205	protein histidine kinase activity
D4A37_RS13230	COG0604	alcohol dehydrogenase
D4A37_RS13235	COG0671	phosphoesterase, PA-phosphatase related
D4A37_RS13240	COG0768	penicillin binding
D4A37_RS13280	COG0789	Transcriptional regulator
D4A37_RS13285	COG2814	Major facilitator Superfamily
D4A37_RS13300	COG0584	glycerophosphoryl diester phosphodiesterase
D4A37_RS13315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS13355	COG2223	nitrite transmembrane transporter activity
D4A37_RS13370	COG2816	NAD+ diphosphatase activity
D4A37_RS13375	COG0592	DNA-directed DNA polymerase activity
D4A37_RS13380	COG1051	belongs to the nudix hydrolase family
D4A37_RS13420	COG4667	esterase of the alpha-beta hydrolase superfamily
D4A37_RS13460	COG0322	excinuclease ABC activity
D4A37_RS13490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A37_RS13520	COG1011	Hydrolase
D4A37_RS13525	COG0745	RESPONSE REGULATOR receiver
D4A37_RS13530	COG5002	protein histidine kinase activity
D4A37_RS13550	COG1136	(ABC) transporter
D4A37_RS13555	COG0577	efflux transmembrane transporter activity
D4A37_RS13570	COG0825	malonyl-CoA metabolic process
D4A37_RS13580	COG2132	Multicopper oxidase
D4A37_RS13600	COG1523	belongs to the glycosyl hydrolase 13 family
D4A37_RS13605	COG3227	Zinc metalloprotease (Elastase)
D4A37_RS13610	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS13620	COG0201	protein transport
D4A37_RS13630	COG0697	spore germination
D4A37_RS13635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS13640	COG0604	alcohol dehydrogenase
D4A37_RS13685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS13700	COG2959	enzyme of heme biosynthesis
D4A37_RS13725	COG3483	tryptophan 2,3-dioxygenase activity
D4A37_RS13740	COG1309	transcriptional regulator
D4A37_RS13765	COG3284	Transcriptional regulator
D4A37_RS13780	COG1349	DNA-binding transcription factor activity
D4A37_RS13795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D4A37_RS13800	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A37_RS13805	COG0022	dehydrogenase e1 component
D4A37_RS13810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D4A37_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS13825	COG0456	acetyltransferase
D4A37_RS13825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D4A37_RS13830	COG0572	uridine kinase
D4A37_RS13850	COG0494	nUDIX hydrolase
D4A37_RS13875	COG4176	ABC-type proline glycine betaine transport system permease component
D4A37_RS13880	COG4175	Glycine betaine
D4A37_RS13880	COG0517	IMP dehydrogenase activity
D4A37_RS13910	COG2153	protein acetylation
D4A37_RS13915	COG3397	chitin binding
D4A37_RS13920	COG1819	glycosyl
D4A37_RS13935	COG2205	protein histidine kinase activity
D4A37_RS13940	COG2226	methyltransferase
D4A37_RS13945	COG2315	Protein conserved in bacteria
D4A37_RS13995	COG3973	AAA domain
D4A37_RS14010	COG2105	PFAM AIG2 family protein
D4A37_RS14015	COG0514	ATP-dependent DNA helicase (RecQ)
D4A37_RS14045	COG4637	Psort location Cytoplasmic, score
D4A37_RS14070	COG3397	chitin binding
D4A37_RS14075	COG2318	DinB family
D4A37_RS14090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D4A37_RS14095	COG1115	amino acid carrier protein
D4A37_RS14100	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS14105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A37_RS14115	COG3938	Belongs to the proline racemase family
D4A37_RS14120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A37_RS14160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D4A37_RS14165	COG1078	dGTPase activity
D4A37_RS14170	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS14190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS14195	COG4166	transmembrane transport
D4A37_RS14205	COG4948	Mandelate Racemase Muconate Lactonizing
D4A37_RS14220	COG0667	Aldo Keto reductase
D4A37_RS14265	COG2936	dipeptidyl-peptidase activity
D4A37_RS14270	COG5002	protein histidine kinase activity
D4A37_RS14275	COG0745	RESPONSE REGULATOR receiver
D4A37_RS14315	COG1164	Oligoendopeptidase f
D4A37_RS14320	COG0531	amino acid
D4A37_RS14325	COG1522	sequence-specific DNA binding
D4A37_RS14330	COG1307	EDD domain protein, DegV family
D4A37_RS14360	COG1335	isochorismatase
D4A37_RS14375	COG2814	Major facilitator Superfamily
D4A37_RS14385	COG1664	Polymer-forming cytoskeletal
D4A37_RS14390	COG0789	Transcriptional regulator
D4A37_RS14395	COG4533	DNA binding
D4A37_RS14400	COG0477	Major facilitator Superfamily
D4A37_RS14400	COG2814	Major facilitator Superfamily
D4A37_RS14420	COG2261	transglycosylase associated protein
D4A37_RS14435	COG2226	methyltransferase
D4A37_RS14475	COG0436	Aminotransferase
D4A37_RS14480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D4A37_RS14490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D4A37_RS14505	COG1131	(ABC) transporter
D4A37_RS14560	COG0628	permease
D4A37_RS14590	COG2746	aminoglycoside 3-N-acetyltransferase activity
D4A37_RS14615	COG0697	spore germination
D4A37_RS14620	COG2318	DinB family
D4A37_RS14650	COG0346	lactoylglutathione lyase activity
D4A37_RS14665	COG0861	Integral membrane protein TerC family
D4A37_RS14670	COG1368	sulfuric ester hydrolase activity
D4A37_RS14680	COG0488	(ABC) transporter
D4A37_RS14690	COG2409	Drug exporters of the RND superfamily
D4A37_RS14690	COG1033	growth of symbiont in host cell
D4A37_RS14695	COG1309	transcriptional regulator
D4A37_RS14710	COG0287	Prephenate dehydrogenase
D4A37_RS14725	COG1605	Chorismate mutase
D4A37_RS14725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D4A37_RS14745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D4A37_RS14745	COG2308	Evidence 4 Homologs of previously reported genes of
D4A37_RS14775	COG1388	LysM domain
D4A37_RS14775	COG3584	3D domain protein
D4A37_RS14795	COG2610	gluconate transmembrane transporter activity
D4A37_RS14800	COG1024	Enoyl-CoA hydratase
D4A37_RS14810	COG3290	protein histidine kinase activity
D4A37_RS14810	COG3829	transcription factor binding
D4A37_RS14840	COG1129	ABC transporter
D4A37_RS14845	COG2390	Transcriptional regulator
D4A37_RS14885	COG2329	Antibiotic biosynthesis monooxygenase
D4A37_RS14900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS14905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D4A37_RS14915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D4A37_RS14920	COG4187	Peptidase family M20/M25/M40
D4A37_RS14925	COG1414	Transcriptional regulator
D4A37_RS14935	COG0833	amino acid
D4A37_RS14945	COG1690	Belongs to the RtcB family
D4A37_RS14950	COG3239	Fatty acid desaturase
D4A37_RS14960	COG1785	Belongs to the alkaline phosphatase family
D4A37_RS14970	COG3655	Transcriptional regulator
D4A37_RS14985	COG4377	Putative membrane peptidase family (DUF2324)
D4A37_RS14995	COG3279	Response regulator of the LytR AlgR family
D4A37_RS15015	COG0346	lactoylglutathione lyase activity
D4A37_RS15040	COG0714	Associated with various cellular activities
D4A37_RS15090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D4A37_RS15095	COG0753	catalase activity
D4A37_RS15105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D4A37_RS15130	COG0714	Associated with various cellular activities
D4A37_RS15210	COG0778	Nitroreductase
D4A37_RS15215	COG1846	Transcriptional regulator
D4A37_RS15255	COG1725	Transcriptional regulator
D4A37_RS15290	COG0456	acetyltransferase
D4A37_RS15310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS15335	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D4A37_RS15335	COG0456	acetyltransferase
D4A37_RS15355	COG0730	response to heat
D4A37_RS15365	COG0833	amino acid
D4A37_RS15375	COG4335	DNA alkylation repair
D4A37_RS15395	COG0384	phenazine biosynthesis protein PhzF
D4A37_RS15415	COG0768	penicillin binding
D4A37_RS15450	COG1984	allophanate hydrolase subunit 2
D4A37_RS15455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D4A37_RS15460	COG1414	Transcriptional regulator
D4A37_RS15475	COG3142	Participates in the control of copper homeostasis
D4A37_RS15480	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS15485	COG0640	Transcriptional regulator
D4A37_RS15500	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS15515	COG3314	Sporulation integral membrane protein YlbJ
D4A37_RS15535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D4A37_RS15550	COG0574	Belongs to the PEP-utilizing enzyme family
D4A37_RS15550	COG3848	Pyruvate phosphate dikinase
D4A37_RS15565	COG4085	toxin activity
D4A37_RS15565	COG1525	nuclease
D4A37_RS15565	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS15570	COG0598	Magnesium transport protein CorA
D4A37_RS15620	COG0415	Belongs to the DNA photolyase family
D4A37_RS15625	COG0288	reversible hydration of carbon dioxide
D4A37_RS15635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A37_RS15640	COG5609	conserved protein (DUF2294)
D4A37_RS15655	COG1575	Belongs to the MenA family. Type 1 subfamily
D4A37_RS15700	COG1329	Transcriptional regulator
D4A37_RS15735	COG1476	TRANSCRIPTIONal
D4A37_RS15815	COG4641	Protein conserved in bacteria
D4A37_RS15840	COG0798	PFAM Bile acid sodium symporter
D4A37_RS15845	COG0346	lactoylglutathione lyase activity
D4A37_RS15850	COG0640	Transcriptional regulator
D4A37_RS15865	COG1309	transcriptional regulator
D4A37_RS15870	COG2186	Transcriptional regulator
D4A37_RS15885	COG0814	amino acid
D4A37_RS15890	COG0697	spore germination
D4A37_RS15895	COG2814	Major facilitator Superfamily
D4A37_RS15900	COG1309	transcriptional regulator
D4A37_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS15910	COG1522	sequence-specific DNA binding
D4A37_RS15925	COG0346	lactoylglutathione lyase activity
D4A37_RS15965	COG2814	Major facilitator Superfamily
D4A37_RS15975	COG4895	conserved protein (DUF2196)
D4A37_RS16045	COG0745	RESPONSE REGULATOR receiver
D4A37_RS16050	COG5002	protein histidine kinase activity
D4A37_RS16050	COG3850	Histidine kinase
D4A37_RS16080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D4A37_RS16110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS16115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A37_RS16125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS16140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D4A37_RS16160	COG0577	efflux transmembrane transporter activity
D4A37_RS16180	COG3850	Histidine kinase
D4A37_RS16180	COG5002	protein histidine kinase activity
D4A37_RS16190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS16220	COG1619	proteins homologs of microcin C7 resistance protein MccF
D4A37_RS16240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D4A37_RS16275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A37_RS16320	COG2814	Major facilitator Superfamily
D4A37_RS16395	COG2849	repeat protein
D4A37_RS16680	COG0477	Major facilitator Superfamily
D4A37_RS16695	COG1846	Transcriptional regulator
D4A37_RS16700	COG2814	Major facilitator Superfamily
D4A37_RS16710	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D4A37_RS16715	COG1131	(ABC) transporter
D4A37_RS16740	COG2031	fatty acid transporter
D4A37_RS16750	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4A37_RS16785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D4A37_RS16805	COG1288	antiporter activity
D4A37_RS16810	COG2356	endonuclease I
D4A37_RS16820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D4A37_RS16855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D4A37_RS16885	COG1733	regulation of RNA biosynthetic process
D4A37_RS16890	COG0778	Nitroreductase
D4A37_RS16900	COG0469	pyruvate kinase activity
D4A37_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS16920	COG1131	(ABC) transporter
D4A37_RS16945	COG1011	Hydrolase
D4A37_RS16955	COG2365	Tyrosine phosphatase family
D4A37_RS16970	COG2816	NAD+ diphosphatase activity
D4A37_RS16980	COG0346	lactoylglutathione lyase activity
D4A37_RS16985	COG1940	carbohydrate kinase activity
D4A37_RS16990	COG0738	Major facilitator superfamily
D4A37_RS16995	COG0110	maltose O-acetyltransferase activity
D4A37_RS17005	COG0577	efflux transmembrane transporter activity
D4A37_RS17005	COG1136	(ABC) transporter
D4A37_RS17020	COG0628	permease
D4A37_RS17045	COG0500	methyltransferase
D4A37_RS17055	COG0477	Major facilitator Superfamily
D4A37_RS17085	COG1253	flavin adenine dinucleotide binding
D4A37_RS17090	COG0789	Transcriptional regulator
D4A37_RS17095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D4A37_RS17120	COG0697	spore germination
D4A37_RS17125	COG1357	PFAM Pentapeptide repeats (8 copies)
D4A37_RS17130	COG3813	Protein conserved in bacteria
D4A37_RS17135	COG2706	6-phosphogluconolactonase activity
D4A37_RS17140	COG1070	Carbohydrate kinase
D4A37_RS17150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D4A37_RS17155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D4A37_RS17170	COG0814	amino acid
D4A37_RS17195	COG1393	Belongs to the ArsC family
D4A37_RS17205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS17225	COG0384	phenazine biosynthesis protein PhzF
D4A37_RS17245	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS17250	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4A37_RS17255	COG1733	regulation of RNA biosynthetic process
D4A37_RS17270	COG1191	sigma factor activity
D4A37_RS17290	COG1876	peptidase activity
D4A37_RS17320	COG5002	protein histidine kinase activity
D4A37_RS17345	COG0657	acetylesterase activity
D4A37_RS17355	COG2814	Major facilitator Superfamily
D4A37_RS17360	COG1309	transcriptional regulator
D4A37_RS17365	COG1280	lysine exporter protein (LysE YggA)
D4A37_RS17405	COG1151	hydroxylamine reductase activity
D4A37_RS17410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS17415	COG3409	Peptidoglycan-binding domain 1 protein
D4A37_RS17415	COG3757	hydrolase, family 25
D4A37_RS17495	COG1695	Transcriptional regulator
D4A37_RS17500	COG0604	alcohol dehydrogenase
D4A37_RS17505	COG1113	amino acid transport
D4A37_RS17510	COG2814	Major facilitator Superfamily
D4A37_RS17530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D4A37_RS17535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D4A37_RS17550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS17555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS17560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS17565	COG3739	integral membrane protein
D4A37_RS17585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS17600	COG0583	DNA-binding transcription factor activity
D4A37_RS17620	COG1193	negative regulation of DNA recombination
D4A37_RS17630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D4A37_RS17635	COG1164	Oligoendopeptidase f
D4A37_RS17640	COG2957	Belongs to the agmatine deiminase family
D4A37_RS17660	COG4978	Transcriptional regulator
D4A37_RS17660	COG0789	Transcriptional regulator
D4A37_RS17675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D4A37_RS17705	COG0584	glycerophosphoryl diester phosphodiesterase
D4A37_RS17730	COG0640	Transcriptional regulator
D4A37_RS17735	COG0604	alcohol dehydrogenase
D4A37_RS17745	COG0457	Tetratricopeptide repeat
D4A37_RS17750	COG2808	Putative FMN-binding domain
D4A37_RS17755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D4A37_RS17765	COG0385	Bile acid
D4A37_RS17770	COG0277	FAD linked oxidase domain protein
D4A37_RS17805	COG0745	RESPONSE REGULATOR receiver
D4A37_RS17810	COG2205	protein histidine kinase activity
D4A37_RS17815	COG1136	(ABC) transporter
D4A37_RS17820	COG0577	efflux transmembrane transporter activity
D4A37_RS17840	COG1285	pathogenesis
D4A37_RS17855	COG2514	catechol 2,3-dioxygenase activity
D4A37_RS17860	COG2720	vancomycin resistance protein
D4A37_RS17885	COG1278	Cold shock
D4A37_RS17895	COG0716	FMN binding
D4A37_RS17945	COG0739	heme binding
D4A37_RS17950	COG0741	lytic transglycosylase activity
D4A37_RS17955	COG3757	hydrolase, family 25
D4A37_RS17955	COG3409	Peptidoglycan-binding domain 1 protein
D4A37_RS17960	COG0739	heme binding
D4A37_RS18010	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS18020	COG0165	Argininosuccinate lyase
D4A37_RS18035	COG4145	pantothenate transmembrane transporter activity
D4A37_RS18045	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS18060	COG1657	PFAM Prenyltransferase squalene oxidase
D4A37_RS18065	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D4A37_RS18070	COG2962	Rard protein
D4A37_RS18075	COG3326	Membrane
D4A37_RS18090	COG0489	protein tyrosine kinase activity
D4A37_RS18100	COG0314	molybdopterin synthase activity
D4A37_RS18105	COG0303	'Molybdopterin
D4A37_RS18110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4A37_RS18115	COG2116	formate transmembrane transporter activity
D4A37_RS18125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D4A37_RS18130	COG5609	conserved protein (DUF2294)
D4A37_RS18135	COG2427	Protein of unknown function (DUF1641)
D4A37_RS18140	COG3383	formate dehydrogenase (NAD+) activity
D4A37_RS18145	COG0697	spore germination
D4A37_RS18190	COG2226	methyltransferase
D4A37_RS18195	COG4166	transmembrane transport
D4A37_RS18200	COG4166	transmembrane transport
D4A37_RS18205	COG4166	transmembrane transport
D4A37_RS18215	COG1316	TRANSCRIPTIONal
D4A37_RS18225	COG1595	DNA-templated transcription, initiation
D4A37_RS18240	COG1131	(ABC) transporter
D4A37_RS18260	COG0673	inositol 2-dehydrogenase activity
D4A37_RS18265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4A37_RS18270	COG0187	DNA topoisomerase II activity
D4A37_RS18275	COG1832	CoA-binding protein
D4A37_RS18280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D4A37_RS18285	COG0745	RESPONSE REGULATOR receiver
D4A37_RS18305	COG4841	protein insertion into membrane
D4A37_RS18310	COG0824	Thioesterase
D4A37_RS18340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A37_RS18350	COG1132	(ABC) transporter
D4A37_RS18355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D4A37_RS18385	COG2211	Major facilitator Superfamily
D4A37_RS18395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D4A37_RS18410	COG0183	Belongs to the thiolase family
D4A37_RS18415	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS18420	COG1268	BioY protein
D4A37_RS18425	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS18440	COG1396	sequence-specific DNA binding
D4A37_RS18475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS18485	COG5002	protein histidine kinase activity
D4A37_RS18490	COG0400	carboxylic ester hydrolase activity
D4A37_RS18495	COG0346	lactoylglutathione lyase activity
D4A37_RS18500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4A37_RS18505	COG0069	glutamate synthase activity
D4A37_RS18510	COG1902	pentaerythritol trinitrate reductase activity
D4A37_RS18515	COG1329	Transcriptional regulator
D4A37_RS18520	COG0010	Belongs to the arginase family
D4A37_RS18545	COG2226	methyltransferase
D4A37_RS18575	COG4846	Membrane protein involved in cytochrome C biogenesis
D4A37_RS18580	COG0785	Cytochrome C biogenesis protein
D4A37_RS18595	COG1473	amidohydrolase
D4A37_RS18605	COG1131	(ABC) transporter
D4A37_RS18620	COG0583	DNA-binding transcription factor activity
D4A37_RS18630	COG1346	cytolysis
D4A37_RS18645	COG0730	response to heat
D4A37_RS18670	COG1132	(ABC) transporter
D4A37_RS18675	COG1132	(ABC) transporter
D4A37_RS18680	COG3763	UPF0154 protein
D4A37_RS18705	COG3639	organic phosphonate transmembrane transporter activity
D4A37_RS18720	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS18730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A37_RS18750	COG1695	Transcriptional regulator
D4A37_RS18755	COG1132	(ABC) transporter
D4A37_RS18785	COG0367	asparagine synthase
D4A37_RS18790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D4A37_RS18795	COG0110	maltose O-acetyltransferase activity
D4A37_RS18800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D4A37_RS18815	COG1216	Glycosyl transferase, family 2
D4A37_RS18815	COG1442	glycosyl transferase family 8
D4A37_RS18830	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS18840	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS18850	COG0463	Glycosyl transferase, family 2
D4A37_RS18850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D4A37_RS18855	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS18860	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS18865	COG1086	Polysaccharide biosynthesis protein
D4A37_RS18870	COG0489	protein tyrosine kinase activity
D4A37_RS18900	COG5632	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS19035	COG1595	DNA-templated transcription, initiation
D4A37_RS19075	COG0270	DNA (cytosine-5-)-methyltransferase activity
D4A37_RS19085	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D4A37_RS19165	COG1396	sequence-specific DNA binding
D4A37_RS19180	COG0174	glutamine synthetase
D4A37_RS19185	COG0789	Transcriptional regulator
D4A37_RS19190	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D4A37_RS19195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D4A37_RS19200	COG2860	membrane
D4A37_RS19205	COG0464	growth
D4A37_RS19235	COG3584	3D domain protein
D4A37_RS19235	COG1388	LysM domain
D4A37_RS19240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A37_RS19240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D4A37_RS19240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D4A37_RS19245	COG1105	Belongs to the carbohydrate kinase PfkB family
D4A37_RS19250	COG1349	DNA-binding transcription factor activity
D4A37_RS19255	COG1979	alcohol dehydrogenase
D4A37_RS19260	COG2322	membrane
D4A37_RS19270	COG1113	amino acid transport
D4A37_RS19280	COG1408	metallophosphoesterase
D4A37_RS19285	COG2116	formate transmembrane transporter activity
D4A37_RS19300	COG2217	Heavy metal translocating P-type atpase
D4A37_RS19305	COG2608	mercury ion transmembrane transporter activity
D4A37_RS19310	COG1937	Protein conserved in bacteria
D4A37_RS19320	COG2819	hydrolase of the alpha beta superfamily
D4A37_RS19325	COG1120	ATPase activity
D4A37_RS19330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS19335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS19340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS19345	COG0708	Exodeoxyribonuclease III
D4A37_RS19350	COG2169	Transcriptional regulator
D4A37_RS19355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D4A37_RS19360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D4A37_RS19370	COG2364	Membrane
D4A37_RS19390	COG5001	Diguanylate cyclase
D4A37_RS19390	COG3300	MHYT domain
D4A37_RS19410	COG1086	Polysaccharide biosynthesis protein
D4A37_RS19430	COG1346	cytolysis
D4A37_RS19435	COG1380	Effector of murein hydrolase LrgA
D4A37_RS19440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A37_RS19450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D4A37_RS19460	COG2188	Transcriptional regulator
D4A37_RS19465	COG2723	6-phospho-beta-galactosidase activity
D4A37_RS19470	COG0840	transmembrane signaling receptor activity
D4A37_RS19480	COG1404	Belongs to the peptidase S8 family
D4A37_RS19485	COG3773	Cell wall hydrolase
D4A37_RS19500	COG1368	sulfuric ester hydrolase activity
D4A37_RS19505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D4A37_RS19515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D4A37_RS19525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D4A37_RS19535	COG4550	Control of competence regulator ComK, YlbF/YmcA
D4A37_RS19545	COG1013	pyruvate-flavodoxin oxidoreductase activity
D4A37_RS19550	COG0674	pyruvate-flavodoxin oxidoreductase activity
D4A37_RS19550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D4A37_RS19560	COG2359	stage V sporulation protein S
D4A37_RS19565	COG1692	metallophosphoesterase
D4A37_RS19570	COG1418	mRNA catabolic process
D4A37_RS19595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D4A37_RS19600	COG1426	Protein conserved in bacteria
D4A37_RS19615	COG0300	oxidoreductase activity
D4A37_RS19620	COG0612	Peptidase, M16
D4A37_RS19625	COG0612	Peptidase, M16
D4A37_RS19630	COG1079	Belongs to the binding-protein-dependent transport system permease family
D4A37_RS19635	COG4603	Belongs to the binding-protein-dependent transport system permease family
D4A37_RS19640	COG3845	ABC transporter
D4A37_RS19645	COG1744	ABC transporter substrate-binding protein PnrA-like
D4A37_RS19650	COG2188	Transcriptional regulator
D4A37_RS19660	COG1674	ftsk spoiiie
D4A37_RS19670	COG0740	serine-type endopeptidase activity
D4A37_RS19675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D4A37_RS19685	COG0527	aspartate kinase activity
D4A37_RS19690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D4A37_RS19695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D4A37_RS19700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4A37_RS19705	COG1873	PFAM PRC-barrel domain
D4A37_RS19710	COG0612	Peptidase, M16
D4A37_RS19715	COG0726	polysaccharide deacetylase
D4A37_RS19730	COG0196	riboflavin kinase activity
D4A37_RS19745	COG1550	Protein conserved in bacteria
D4A37_RS19755	COG1358	cellular component organization or biogenesis
D4A37_RS19760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D4A37_RS19765	COG0195	Participates in both transcription termination and antitermination
D4A37_RS19785	COG0750	zinc metalloprotease
D4A37_RS19795	COG4589	Belongs to the CDS family
D4A37_RS19805	COG0233	cytoplasmic translational termination
D4A37_RS19815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D4A37_RS19840	COG4974	Belongs to the 'phage' integrase family
D4A37_RS19850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4A37_RS19855	COG0758	DNA mediated transformation
D4A37_RS19860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D4A37_RS19900	COG1837	Belongs to the UPF0109 family
D4A37_RS19910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D4A37_RS19920	COG0552	protein localization to endoplasmic reticulum
D4A37_RS19925	COG1196	nuclear chromosome segregation
D4A37_RS19935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D4A37_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS19945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D4A37_RS19960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D4A37_RS19965	COG1461	Dihydroxyacetone kinase
D4A37_RS19970	COG1302	Protein conserved in bacteria
D4A37_RS19985	COG1564	THIamine pyrophosphokinase
D4A37_RS19990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D4A37_RS20000	COG0515	serine threonine protein kinase
D4A37_RS20000	COG2815	serine threonine protein kinase
D4A37_RS20005	COG0631	protein serine/threonine phosphatase activity
D4A37_RS20010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D4A37_RS20015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D4A37_RS20015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D4A37_RS20025	COG0242	peptide deformylase activity
D4A37_RS20030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D4A37_RS20035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D4A37_RS20040	COG1758	RNA polymerase activity
D4A37_RS20055	COG1561	YicC-like family, N-terminal region
D4A37_RS20060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D4A37_RS20075	COG0006	proline dipeptidase activity
D4A37_RS20095	COG3069	C4-dicarboxylate transmembrane transporter activity
D4A37_RS20125	COG0543	2 iron, 2 sulfur cluster binding
D4A37_RS20160	COG0564	pseudouridine synthase activity
D4A37_RS20180	COG3599	regulation of cell shape
D4A37_RS20185	COG2302	S4 RNA-binding domain
D4A37_RS20190	COG0762	integral membrane protein
D4A37_RS20200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D4A37_RS20210	COG1873	PFAM PRC-barrel domain
D4A37_RS20215	COG1191	sigma factor activity
D4A37_RS20220	COG1191	sigma factor activity
D4A37_RS20230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D4A37_RS20235	COG0849	cell division
D4A37_RS20240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D4A37_RS20255	COG0772	Belongs to the SEDS family
D4A37_RS20270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D4A37_RS20275	COG0768	penicillin binding
D4A37_RS20280	COG0768	penicillin binding
D4A37_RS20285	COG4839	cell division protein FtsL
D4A37_RS20300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D4A37_RS20315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D4A37_RS20320	COG1399	metal-binding, possibly nucleic acid-binding protein
D4A37_RS20330	COG3480	Lon protease (S16) C-terminal proteolytic domain
D4A37_RS20335	COG1752	Esterase of the alpha-beta hydrolase superfamily
D4A37_RS20340	COG3314	Sporulation integral membrane protein YlbJ
D4A37_RS20350	COG0742	ribosomal rna small subunit methyltransferase
D4A37_RS20365	COG3679	Belongs to the UPF0342 family
D4A37_RS20370	COG0406	alpha-ribazole phosphatase activity
D4A37_RS20385	COG2340	Cysteine-rich secretory protein family
D4A37_RS20405	COG3336	cytochrome c oxidase
D4A37_RS20440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D4A37_RS20450	COG0772	Belongs to the SEDS family
D4A37_RS20455	COG4838	Belongs to the UPF0358 family
D4A37_RS20460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D4A37_RS20465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D4A37_RS20475	COG4896	Protein conserved in bacteria
D4A37_RS20490	COG1217	gtp-binding protein TYPA
D4A37_RS20500	COG0483	inositol monophosphate 1-phosphatase activity
D4A37_RS20520	COG1982	Orn Lys Arg decarboxylase major
D4A37_RS20570	COG0022	dehydrogenase e1 component
D4A37_RS20575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D4A37_RS20590	COG0561	phosphatase activity
D4A37_RS20605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D4A37_RS20610	COG0569	domain protein
D4A37_RS20625	COG2171	N-acyltransferase activity
D4A37_RS20630	COG0583	DNA-binding transcription factor activity
D4A37_RS20635	COG0517	IMP dehydrogenase activity
D4A37_RS20645	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D4A37_RS20650	COG4703	Protein of unknown function (DUF1797)
D4A37_RS20665	COG2200	EAL domain
D4A37_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS20675	COG1408	metallophosphoesterase
D4A37_RS20695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D4A37_RS20730	COG2814	Major facilitator Superfamily
D4A37_RS20755	COG3209	COG3209 Rhs family protein
D4A37_RS20765	COG2205	protein histidine kinase activity
D4A37_RS20775	COG0436	Aminotransferase
D4A37_RS20780	COG1609	Transcriptional regulator
D4A37_RS20785	COG3833	ABC-type maltose transport systems, permease component
D4A37_RS20790	COG1175	transmembrane transport
D4A37_RS20795	COG2182	Extracellular solute-binding protein
D4A37_RS20805	COG0366	Alpha amylase catalytic
D4A37_RS20810	COG3842	ATPase activity
D4A37_RS20855	COG0183	Belongs to the thiolase family
D4A37_RS20890	COG1695	Transcriptional regulator
D4A37_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS20915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4A37_RS20920	COG0436	Aminotransferase
D4A37_RS20955	COG2084	Dehydrogenase
D4A37_RS20965	COG2199	diguanylate cyclase activity
D4A37_RS20970	COG0778	Nitroreductase
D4A37_RS20995	COG2190	(PTS) system
D4A37_RS20995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A37_RS20995	COG1263	PTS System
D4A37_RS21000	COG3711	transcriptional antiterminator
D4A37_RS21010	COG2188	Transcriptional regulator
D4A37_RS21020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D4A37_RS21050	COG1547	Domain of unknown function (DUF309)
D4A37_RS21055	COG0456	acetyltransferase
D4A37_RS21065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D4A37_RS21070	COG4086	secreted protein
D4A37_RS21075	COG0561	phosphatase activity
D4A37_RS21080	COG0697	spore germination
D4A37_RS21095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS21120	COG0733	neurotransmitter:sodium symporter activity
D4A37_RS21140	COG1686	Belongs to the peptidase S11 family
D4A37_RS21150	COG1725	Transcriptional regulator
D4A37_RS21155	COG1131	(ABC) transporter
D4A37_RS21175	COG1846	Transcriptional regulator
D4A37_RS21190	COG0598	Magnesium transport protein CorA
D4A37_RS21215	COG4974	Belongs to the 'phage' integrase family
D4A37_RS21225	COG0735	belongs to the Fur family
D4A37_RS21230	COG1300	Membrane
D4A37_RS21250	COG0667	Aldo Keto reductase
D4A37_RS21255	COG0656	L-ascorbic acid biosynthetic process
D4A37_RS21260	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D4A37_RS21260	COG0456	acetyltransferase
D4A37_RS21270	COG4085	toxin activity
D4A37_RS21270	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS21270	COG1525	nuclease
D4A37_RS21280	COG0596	Alpha beta hydrolase
D4A37_RS21285	COG2056	Na+-H+ antiporter family
D4A37_RS21290	COG1609	Transcriptional regulator
D4A37_RS21295	COG0456	acetyltransferase
D4A37_RS21300	COG1073	alpha beta
D4A37_RS21320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A37_RS21320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A37_RS21325	COG0307	riboflavin synthase, alpha
D4A37_RS21350	COG4106	trans-aconitate 2-methyltransferase activity
D4A37_RS21355	COG2226	methyltransferase
D4A37_RS21355	COG1073	alpha beta
D4A37_RS21370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4A37_RS21380	COG1757	Na H antiporter
D4A37_RS21385	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS21395	COG1522	sequence-specific DNA binding
D4A37_RS21415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D4A37_RS21440	COG0300	oxidoreductase activity
D4A37_RS21445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS21450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D4A37_RS21455	COG1760	l-serine dehydratase
D4A37_RS21460	COG1760	l-serine dehydratase
D4A37_RS21490	COG2195	Cleaves the N-terminal amino acid of tripeptides
D4A37_RS21495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS21510	COG1376	ErfK ybiS ycfS ynhG family protein
D4A37_RS21515	COG4129	membrane
D4A37_RS21520	COG1126	abc transporter atp-binding protein
D4A37_RS21525	COG0765	amino acid transport
D4A37_RS21530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A37_RS21550	COG2323	membrane
D4A37_RS21555	COG0772	Belongs to the SEDS family
D4A37_RS21565	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A37_RS21570	COG0022	dehydrogenase e1 component
D4A37_RS21575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D4A37_RS21580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D4A37_RS21595	COG0280	phosphate acetyltransferase
D4A37_RS21605	COG3829	transcription factor binding
D4A37_RS21605	COG3290	protein histidine kinase activity
D4A37_RS21615	COG0584	glycerophosphoryl diester phosphodiesterase
D4A37_RS21620	COG3093	addiction module antidote protein HigA
D4A37_RS21630	COG0745	RESPONSE REGULATOR receiver
D4A37_RS21640	COG0750	zinc metalloprotease
D4A37_RS21645	COG0497	DNA recombination
D4A37_RS21655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D4A37_RS21665	COG0142	geranyltranstransferase activity
D4A37_RS21690	COG1302	Protein conserved in bacteria
D4A37_RS21695	COG0439	Biotin carboxylase
D4A37_RS21700	COG0511	ligase activity, forming carbon-carbon bonds
D4A37_RS21745	COG3854	ATPases associated with a variety of cellular activities
D4A37_RS21765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D4A37_RS21770	COG0006	proline dipeptidase activity
D4A37_RS21785	COG3872	metal-dependent enzyme
D4A37_RS21795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A37_RS21825	COG0095	Lipoate-protein ligase
D4A37_RS21830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A37_RS21840	COG1609	Transcriptional regulator
D4A37_RS21850	COG2076	Multidrug Resistance protein
D4A37_RS21855	COG2076	Multidrug Resistance protein
D4A37_RS21890	COG1131	(ABC) transporter
D4A37_RS21895	COG1725	Transcriptional regulator
D4A37_RS21910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D4A37_RS21925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D4A37_RS22015	COG4824	toxin secretion phage lysis holin
D4A37_RS22095	COG0740	serine-type endopeptidase activity
D4A37_RS22105	COG4626	Terminase
D4A37_RS22105	COG1802	Transcriptional regulator
D4A37_RS22140	COG0582	viral genome integration into host DNA
D4A37_RS22230	COG1396	sequence-specific DNA binding
D4A37_RS22260	COG4970	Tfp pilus assembly protein FimT
D4A37_RS22270	COG1459	type II secretion system
D4A37_RS22275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D4A37_RS22325	COG1410	methionine synthase
D4A37_RS22325	COG0646	methionine synthase
D4A37_RS22330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D4A37_RS22330	COG0646	methionine synthase
D4A37_RS22335	COG0626	cystathionine gamma-synthase activity
D4A37_RS22340	COG0626	cystathionine gamma-synthase activity
D4A37_RS22360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS22370	COG1940	carbohydrate kinase activity
D4A37_RS22375	COG4483	Protein conserved in bacteria
D4A37_RS22380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D4A37_RS22385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D4A37_RS22390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D4A37_RS22395	COG0704	Plays a role in the regulation of phosphate uptake
D4A37_RS22405	COG0581	inorganic phosphate transmembrane transporter activity
D4A37_RS22410	COG0573	inorganic phosphate transmembrane transporter activity
D4A37_RS22415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D4A37_RS22420	COG0768	penicillin binding
D4A37_RS22425	COG0477	Major facilitator Superfamily
D4A37_RS22430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D4A37_RS22455	COG0735	belongs to the Fur family
D4A37_RS22460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D4A37_RS22465	COG1121	(ABC) transporter
D4A37_RS22470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS22500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D4A37_RS22505	COG2384	SAM-dependent methyltransferase
D4A37_RS22510	COG2010	Cytochrome c
D4A37_RS22515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4A37_RS22520	COG0358	DNA primase activity
D4A37_RS22530	COG0517	IMP dehydrogenase activity
D4A37_RS22545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D4A37_RS22550	COG0295	cytidine deaminase activity
D4A37_RS22555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D4A37_RS22565	COG1480	7TM receptor with intracellular HD hydrolase
D4A37_RS22570	COG1702	phosphate starvation-inducible protein PhoH
D4A37_RS22585	COG1610	YqeY-like protein
D4A37_RS22590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D4A37_RS22595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4A37_RS22600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D4A37_RS22630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4A37_RS22635	COG1733	regulation of RNA biosynthetic process
D4A37_RS22660	COG1466	dna polymerase III delta subunit
D4A37_RS22670	COG0658	competence protein
D4A37_RS22670	COG2333	competence protein COMEC
D4A37_RS22675	COG2131	deaminase
D4A37_RS22680	COG1596	polysaccharide export
D4A37_RS22680	COG1555	photosystem II stabilization
D4A37_RS22685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D4A37_RS22690	COG2226	methyltransferase
D4A37_RS22695	COG0799	negative regulation of ribosome biogenesis
D4A37_RS22700	COG1713	HD superfamily hydrolase involved in NAD metabolism
D4A37_RS22710	COG1534	Rna-binding protein
D4A37_RS22720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D4A37_RS22725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D4A37_RS22750	COG1595	DNA-templated transcription, initiation
D4A37_RS22765	COG2357	RelA SpoT domain protein
D4A37_RS22775	COG1785	Belongs to the alkaline phosphatase family
D4A37_RS22785	COG2267	carboxylic ester hydrolase activity
D4A37_RS22820	COG1404	Belongs to the peptidase S8 family
D4A37_RS22825	COG3186	Phenylalanine-4-hydroxylase
D4A37_RS22835	COG2514	catechol 2,3-dioxygenase activity
D4A37_RS22840	COG2259	Doxx family
D4A37_RS22880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS22895	COG1012	belongs to the aldehyde dehydrogenase family
D4A37_RS22895	COG1454	alcohol dehydrogenase
D4A37_RS22900	COG0626	cystathionine gamma-synthase activity
D4A37_RS22905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4A37_RS22930	COG0768	penicillin binding
D4A37_RS22950	COG0826	peptidase U32
D4A37_RS22955	COG0826	peptidase U32
D4A37_RS22960	COG4122	O-methyltransferase activity
D4A37_RS22965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D4A37_RS22995	COG0628	permease
D4A37_RS23015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D4A37_RS23030	COG1104	cysteine desulfurase activity
D4A37_RS23035	COG1959	2 iron, 2 sulfur cluster binding
D4A37_RS23040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D4A37_RS23050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D4A37_RS23070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D4A37_RS23080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D4A37_RS23080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D4A37_RS23085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D4A37_RS23090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4A37_RS23090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4A37_RS23100	COG2244	polysaccharide biosynthetic process
D4A37_RS23105	COG2323	membrane
D4A37_RS23115	COG1862	Preprotein translocase
D4A37_RS23145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D4A37_RS23175	COG0157	Belongs to the NadC ModD family
D4A37_RS23180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D4A37_RS23185	COG1104	cysteine desulfurase activity
D4A37_RS23190	COG1827	regulation of RNA biosynthetic process
D4A37_RS23195	COG2258	MOSC domain
D4A37_RS23200	COG0077	Prephenate dehydratase
D4A37_RS23205	COG0577	efflux transmembrane transporter activity
D4A37_RS23210	COG0577	efflux transmembrane transporter activity
D4A37_RS23215	COG1136	(ABC) transporter
D4A37_RS23220	COG5002	protein histidine kinase activity
D4A37_RS23225	COG0745	RESPONSE REGULATOR receiver
D4A37_RS23230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D4A37_RS23235	COG3290	protein histidine kinase activity
D4A37_RS23245	COG2868	ribosomal protein
D4A37_RS23255	COG1530	ribonuclease E activity
D4A37_RS23260	COG1994	Peptidase M50
D4A37_RS23265	COG0739	heme binding
D4A37_RS23270	COG2894	cell division
D4A37_RS23290	COG1077	Cell shape determining protein MreB Mrl
D4A37_RS23310	COG0285	dihydrofolate synthase activity
D4A37_RS23315	COG0525	valine-tRNA ligase activity
D4A37_RS23325	COG1388	LysM domain
D4A37_RS23335	COG0113	porphobilinogen synthase activity
D4A37_RS23340	COG1587	Uroporphyrinogen-III synthase
D4A37_RS23350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4A37_RS23360	COG1846	Transcriptional regulator
D4A37_RS23365	COG1764	response to oxidative stress
D4A37_RS23380	COG0470	DNA polymerase III
D4A37_RS23380	COG1067	ATP-dependent peptidase activity
D4A37_RS23425	COG0622	Phosphoesterase
D4A37_RS23440	COG5401	PFAM Sporulation and spore germination
D4A37_RS23450	COG0477	Major facilitator Superfamily
D4A37_RS23460	COG1309	transcriptional regulator
D4A37_RS23475	COG2197	response regulator
D4A37_RS23480	COG2233	PERMEase
D4A37_RS23485	COG0402	S-adenosylhomocysteine deaminase activity
D4A37_RS23495	COG1396	sequence-specific DNA binding
D4A37_RS23500	COG0697	spore germination
D4A37_RS23510	COG1959	2 iron, 2 sulfur cluster binding
D4A37_RS23515	COG1668	transmembrane transport
D4A37_RS23520	COG4152	abc transporter atp-binding protein
D4A37_RS23525	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D4A37_RS23530	COG1360	Flagellar Motor Protein
D4A37_RS23535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D4A37_RS23540	COG1876	peptidase activity
D4A37_RS23545	COG0824	Thioesterase
D4A37_RS23550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D4A37_RS23555	COG1053	succinate dehydrogenase
D4A37_RS23560	COG2009	succinate dehydrogenase
D4A37_RS23565	COG1719	4-vinyl reductase, 4VR
D4A37_RS23575	COG3118	belongs to the thioredoxin family
D4A37_RS23580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D4A37_RS23585	COG2086	electron transfer activity
D4A37_RS23590	COG1024	Enoyl-CoA hydratase
D4A37_RS23595	COG1309	transcriptional regulator
D4A37_RS23600	COG0318	PFAM AMP-dependent synthetase and ligase
D4A37_RS23615	COG2318	DinB family
D4A37_RS23640	COG1131	(ABC) transporter
D4A37_RS23645	COG2205	protein histidine kinase activity
D4A37_RS23650	COG0745	RESPONSE REGULATOR receiver
D4A37_RS23655	COG4895	conserved protein (DUF2196)
D4A37_RS23660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D4A37_RS23670	COG4509	Sortase family
D4A37_RS23675	COG1120	ATPase activity
D4A37_RS23690	COG5386	Cell surface protein
D4A37_RS23700	COG5386	Cell surface protein
D4A37_RS23705	COG1114	Component of the transport system for branched-chain amino acids
D4A37_RS23710	COG1187	pseudouridine synthase activity
D4A37_RS23720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D4A37_RS23720	COG1796	DNA polymerase
D4A37_RS23725	COG1286	toxin biosynthetic process
D4A37_RS23770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4A37_RS23780	COG1418	mRNA catabolic process
D4A37_RS23805	COG2814	Major facilitator Superfamily
D4A37_RS23810	COG1566	PFAM secretion protein HlyD family protein
D4A37_RS23815	COG1309	transcriptional regulator
D4A37_RS23820	COG1363	Peptidase, m42
D4A37_RS23830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D4A37_RS23845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D4A37_RS23855	COG1484	DNA-dependent DNA replication
D4A37_RS23860	COG3611	Membrane attachment protein
D4A37_RS23870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D4A37_RS23880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4A37_RS23885	COG0237	dephospho-CoA kinase activity
D4A37_RS23890	COG1971	Probably functions as a manganese efflux pump
D4A37_RS23900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A37_RS23900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A37_RS23905	COG5002	protein histidine kinase activity
D4A37_RS23910	COG0745	RESPONSE REGULATOR receiver
D4A37_RS23930	COG0538	isocitrate dehydrogenase activity
D4A37_RS23935	COG0372	Belongs to the citrate synthase family
D4A37_RS23950	COG0628	permease
D4A37_RS23955	COG3030	protein affecting phage T7 exclusion by the F plasmid
D4A37_RS23980	COG1725	Transcriptional regulator
D4A37_RS23985	COG0281	malic enzyme
D4A37_RS23990	COG0587	DNA-directed DNA polymerase activity
D4A37_RS24005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D4A37_RS24025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D4A37_RS24035	COG4109	DRTGG domain
D4A37_RS24045	COG0006	proline dipeptidase activity
D4A37_RS24090	COG0662	Cupin 2, conserved barrel domain protein
D4A37_RS24100	COG1476	TRANSCRIPTIONal
D4A37_RS24115	COG1028	Short-chain dehydrogenase reductase Sdr
D4A37_RS24120	COG0589	response to stress
D4A37_RS24165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS24190	COG0827	DNA restriction-modification system
D4A37_RS24195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D4A37_RS24200	COG3874	Sporulation protein YtfJ
D4A37_RS24215	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D4A37_RS24225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A37_RS24240	COG1104	cysteine desulfurase activity
D4A37_RS24250	COG0583	DNA-binding transcription factor activity
D4A37_RS24255	COG0697	spore germination
D4A37_RS24260	COG1309	transcriptional regulator
D4A37_RS24265	COG1956	GAF domain-containing protein
D4A37_RS24275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D4A37_RS24290	COG0583	DNA-binding transcription factor activity
D4A37_RS24295	COG2814	Major facilitator Superfamily
D4A37_RS24340	COG1595	DNA-templated transcription, initiation
D4A37_RS24350	COG0110	maltose O-acetyltransferase activity
D4A37_RS24355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A37_RS24360	COG0454	-acetyltransferase
D4A37_RS24365	COG0517	IMP dehydrogenase activity
D4A37_RS24370	COG0123	including yeast histone deacetylase and acetoin utilization protein
D4A37_RS24385	COG0745	RESPONSE REGULATOR receiver
D4A37_RS24390	COG5002	protein histidine kinase activity
D4A37_RS24395	COG0666	response to abiotic stimulus
D4A37_RS24430	COG1609	Transcriptional regulator
D4A37_RS24450	COG4851	CamS sex pheromone cAM373 precursor
D4A37_RS24455	COG3118	belongs to the thioredoxin family
D4A37_RS24465	COG2309	aminopeptidase activity
D4A37_RS24490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS24495	COG1695	Transcriptional regulator
D4A37_RS24515	COG1674	ftsk spoiiie
D4A37_RS24530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4A37_RS24540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A37_RS24545	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D4A37_RS24550	COG1363	Peptidase, m42
D4A37_RS24560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS24575	COG0510	thiamine kinase activity
D4A37_RS24580	COG1523	belongs to the glycosyl hydrolase 13 family
D4A37_RS24590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D4A37_RS24595	COG1349	DNA-binding transcription factor activity
D4A37_RS24600	COG1187	pseudouridine synthase activity
D4A37_RS24605	COG2244	polysaccharide biosynthetic process
D4A37_RS24610	COG2081	HI0933 family
D4A37_RS24615	COG2814	Major facilitator Superfamily
D4A37_RS24625	COG3832	glyoxalase III activity
D4A37_RS24650	COG1329	Transcriptional regulator
D4A37_RS24675	COG0314	molybdopterin synthase activity
D4A37_RS24680	COG1763	Mo-molybdopterin cofactor biosynthetic process
D4A37_RS24685	COG0303	'Molybdopterin
D4A37_RS24695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4A37_RS24700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D4A37_RS24720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A37_RS24730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D4A37_RS24775	COG2814	Major facilitator Superfamily
D4A37_RS24780	COG0475	glutathione-regulated potassium exporter activity
D4A37_RS24785	COG0490	domain, Protein
D4A37_RS24790	COG0582	viral genome integration into host DNA
D4A37_RS24800	COG1136	(ABC) transporter
D4A37_RS24820	COG1242	4 iron, 4 sulfur cluster binding
D4A37_RS24825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D4A37_RS24835	COG1131	(ABC) transporter
D4A37_RS24845	COG1794	racemase activity, acting on amino acids and derivatives
D4A37_RS24875	COG2267	carboxylic ester hydrolase activity
D4A37_RS24880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D4A37_RS24885	COG0671	phosphoesterase, PA-phosphatase related
D4A37_RS24890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D4A37_RS24890	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS24900	COG0521	Mo-molybdopterin cofactor biosynthetic process
D4A37_RS24965	COG5002	protein histidine kinase activity
D4A37_RS24970	COG4191	Histidine kinase
D4A37_RS24975	COG0753	catalase activity
D4A37_RS24980	COG2267	carboxylic ester hydrolase activity
D4A37_RS25000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A37_RS25005	COG1116	anion transmembrane transporter activity
D4A37_RS25010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A37_RS25035	COG0494	nUDIX hydrolase
D4A37_RS25075	COG1854	S-ribosylhomocysteine lyase activity
D4A37_RS25085	COG0288	reversible hydration of carbon dioxide
D4A37_RS25090	COG1271	oxidase subunit
D4A37_RS25095	COG1294	oxidase, subunit
D4A37_RS25115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS25140	COG1842	Phage shock protein A
D4A37_RS25165	COG3859	Proton-coupled thiamine transporter YuaJ
D4A37_RS25170	COG5002	protein histidine kinase activity
D4A37_RS25175	COG0745	RESPONSE REGULATOR receiver
D4A37_RS25200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D4A37_RS25205	COG1597	lipid kinase activity
D4A37_RS25245	COG1136	(ABC) transporter
D4A37_RS25260	COG5002	protein histidine kinase activity
D4A37_RS25270	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS25280	COG0577	efflux transmembrane transporter activity
D4A37_RS25285	COG1136	(ABC) transporter
D4A37_RS25290	COG3708	Transcriptional regulator
D4A37_RS25290	COG2207	Transcriptional regulator
D4A37_RS25295	COG5658	integral membrane protein
D4A37_RS25300	COG0640	Transcriptional regulator
D4A37_RS25305	COG0745	RESPONSE REGULATOR receiver
D4A37_RS25310	COG2205	protein histidine kinase activity
D4A37_RS25315	COG0577	efflux transmembrane transporter activity
D4A37_RS25320	COG0577	efflux transmembrane transporter activity
D4A37_RS25325	COG1136	(ABC) transporter
D4A37_RS25330	COG0577	efflux transmembrane transporter activity
D4A37_RS25345	COG2188	Transcriptional regulator
D4A37_RS25365	COG3964	amidohydrolase
D4A37_RS25380	COG0745	RESPONSE REGULATOR receiver
D4A37_RS25385	COG4948	Mandelate Racemase Muconate Lactonizing
D4A37_RS25395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D4A37_RS25400	COG0596	Alpha beta hydrolase
D4A37_RS25410	COG1169	isochorismate synthase
D4A37_RS25415	COG1575	Belongs to the MenA family. Type 1 subfamily
D4A37_RS25420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D4A37_RS25425	COG1278	Cold shock
D4A37_RS25445	COG0058	SHG alpha-glucan phosphorylase activity
D4A37_RS25455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D4A37_RS25465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D4A37_RS25475	COG1404	Belongs to the peptidase S8 family
D4A37_RS25495	COG1595	DNA-templated transcription, initiation
D4A37_RS25630	COG1285	pathogenesis
D4A37_RS25635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D4A37_RS25655	COG2155	Conserved Protein
D4A37_RS25660	COG1098	S1 RNA binding domain
D4A37_RS25665	COG0436	Aminotransferase
D4A37_RS25670	COG1522	sequence-specific DNA binding
D4A37_RS25675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4A37_RS25680	COG2267	carboxylic ester hydrolase activity
D4A37_RS25690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D4A37_RS25705	COG5018	Exonuclease
D4A37_RS25710	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D4A37_RS25735	COG2050	protein possibly involved in aromatic compounds catabolism
D4A37_RS25745	COG1268	BioY protein
D4A37_RS25755	COG0297	glycogen (starch) synthase activity
D4A37_RS25765	COG4485	Bacterial membrane protein, YfhO
D4A37_RS25770	COG2246	polysaccharide biosynthetic process
D4A37_RS25775	COG0463	Glycosyl transferase, family 2
D4A37_RS25780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D4A37_RS25815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D4A37_RS25835	COG3584	3D domain protein
D4A37_RS25850	COG1252	NADH dehydrogenase
D4A37_RS25860	COG3708	Transcriptional regulator
D4A37_RS25875	COG1683	Conserved Protein
D4A37_RS25885	COG4122	O-methyltransferase activity
D4A37_RS25900	COG0316	Belongs to the HesB IscA family
D4A37_RS25915	COG1252	NADH dehydrogenase
D4A37_RS25925	COG2274	protein secretion by the type I secretion system
D4A37_RS25930	COG0390	transport system, permease component
D4A37_RS25935	COG2824	Alkylphosphonate utilization operon protein PhnA
D4A37_RS25955	COG4837	Protein of unknown function (DUF1462)
D4A37_RS25960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D4A37_RS25970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D4A37_RS25975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D4A37_RS25990	COG0577	efflux transmembrane transporter activity
D4A37_RS25990	COG1136	(ABC) transporter
D4A37_RS25995	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4A37_RS26000	COG0647	UMP catabolic process
D4A37_RS26010	COG2445	Protein of unknown function DUF86
D4A37_RS26015	COG1494	fructose-1,6-bisphosphatase
D4A37_RS26035	COG4470	Protein conserved in bacteria
D4A37_RS26045	COG0789	Transcriptional regulator
D4A37_RS26050	COG4377	Putative membrane peptidase family (DUF2324)
D4A37_RS26075	COG0739	heme binding
D4A37_RS26085	COG3377	Domain of unknown function (DUF1805)
D4A37_RS26090	COG0737	Belongs to the 5'-nucleotidase family
D4A37_RS26100	COG0719	Fe-S assembly protein
D4A37_RS26105	COG0822	iron-sulfur transferase activity
D4A37_RS26110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D4A37_RS26115	COG0719	Fe-S assembly protein
D4A37_RS26120	COG0396	ATPase activity
D4A37_RS26125	COG1464	Belongs to the NlpA lipoprotein family
D4A37_RS26130	COG1464	Belongs to the NlpA lipoprotein family
D4A37_RS26135	COG2011	ABC-type metal ion transport system permease component
D4A37_RS26155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A37_RS26160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D4A37_RS26170	COG1393	Belongs to the ArsC family
D4A37_RS26245	COG1309	transcriptional regulator
D4A37_RS26250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A37_RS26255	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS26260	COG0183	Belongs to the thiolase family
D4A37_RS26265	COG1250	3-hydroxyacyl-CoA dehydrogenase
D4A37_RS26265	COG1024	Enoyl-CoA hydratase
D4A37_RS26275	COG1686	Belongs to the peptidase S11 family
D4A37_RS26280	COG0506	proline dehydrogenase activity
D4A37_RS26290	COG0011	TIGRFAM Protein of
D4A37_RS26295	COG0840	transmembrane signaling receptor activity
D4A37_RS26310	COG2814	Major facilitator Superfamily
D4A37_RS26315	COG0531	amino acid
D4A37_RS26335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D4A37_RS26375	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS26385	COG1376	ErfK ybiS ycfS ynhG family protein
D4A37_RS26390	COG0745	RESPONSE REGULATOR receiver
D4A37_RS26395	COG5002	protein histidine kinase activity
D4A37_RS26420	COG0840	transmembrane signaling receptor activity
D4A37_RS26425	COG2151	metal-sulfur cluster biosynthetic enzyme
D4A37_RS26430	COG3227	Zinc metalloprotease (Elastase)
D4A37_RS26435	COG1741	Belongs to the pirin family
D4A37_RS26450	COG0586	Pfam SNARE associated Golgi protein
D4A37_RS26455	COG0475	glutathione-regulated potassium exporter activity
D4A37_RS26460	COG0490	domain, Protein
D4A37_RS26465	COG1115	amino acid carrier protein
D4A37_RS26470	COG0783	Belongs to the Dps family
D4A37_RS26485	COG1611	Belongs to the LOG family
D4A37_RS26500	COG2311	Membrane
D4A37_RS26505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS26510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS26515	COG1115	amino acid carrier protein
D4A37_RS26520	COG1115	amino acid carrier protein
D4A37_RS26525	COG2910	NAD(P)H-binding
D4A37_RS26545	COG0656	L-ascorbic acid biosynthetic process
D4A37_RS26550	COG2814	Major facilitator Superfamily
D4A37_RS26555	COG1733	regulation of RNA biosynthetic process
D4A37_RS26565	COG1252	NADH dehydrogenase
D4A37_RS26570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D4A37_RS26585	COG0840	transmembrane signaling receptor activity
D4A37_RS26585	COG3290	protein histidine kinase activity
D4A37_RS26615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A37_RS26695	COG0557	exoribonuclease II activity
D4A37_RS26700	COG1647	Serine aminopeptidase, S33
D4A37_RS26705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4A37_RS26710	COG1346	cytolysis
D4A37_RS26725	COG0148	phosphopyruvate hydratase activity
D4A37_RS26735	COG0149	triose-phosphate isomerase activity
D4A37_RS26745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4A37_RS26760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D4A37_RS26785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A37_RS26800	COG2323	membrane
D4A37_RS26815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A37_RS26825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D4A37_RS26835	COG1051	belongs to the nudix hydrolase family
D4A37_RS26845	COG0492	ferredoxin-NADP+ reductase activity
D4A37_RS26850	COG0457	Tetratricopeptide repeat
D4A37_RS26855	COG0110	maltose O-acetyltransferase activity
D4A37_RS26875	COG1950	PFAM Membrane protein of
D4A37_RS26885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D4A37_RS26905	COG0789	Transcriptional regulator
D4A37_RS26930	COG0583	DNA-binding transcription factor activity
D4A37_RS26940	COG0655	NAD(P)H dehydrogenase (quinone) activity
D4A37_RS26945	COG0488	(ABC) transporter
D4A37_RS26955	COG1132	(ABC) transporter
D4A37_RS26960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D4A37_RS26965	COG0583	DNA-binding transcription factor activity
D4A37_RS26970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D4A37_RS26975	COG0793	Belongs to the peptidase S41A family
D4A37_RS26975	COG3409	Peptidoglycan-binding domain 1 protein
D4A37_RS26980	COG2177	Part of the ABC transporter FtsEX involved in
D4A37_RS26985	COG2884	Cell division ATP-binding protein ftsE
D4A37_RS27005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D4A37_RS27010	COG1278	Cold shock
D4A37_RS27015	COG1040	competence protein
D4A37_RS27020	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D4A37_RS27025	COG0791	NLP P60 protein
D4A37_RS27025	COG1388	LysM domain
D4A37_RS27030	COG1733	regulation of RNA biosynthetic process
D4A37_RS27035	COG1307	EDD domain protein, DegV family
D4A37_RS27040	COG1739	Uncharacterized protein family UPF0029
D4A37_RS27045	COG1316	TRANSCRIPTIONal
D4A37_RS27050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D4A37_RS27055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D4A37_RS27060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D4A37_RS27070	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D4A37_RS27070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D4A37_RS27090	COG1486	melibiose metabolic process
D4A37_RS27095	COG1447	Phosphotransferase system cellobiose-specific component IIA
D4A37_RS27100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D4A37_RS27110	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D4A37_RS27120	COG1447	Phosphotransferase system cellobiose-specific component IIA
D4A37_RS27130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D4A37_RS27135	COG1301	dicarboxylic acid transport
D4A37_RS27145	COG0346	lactoylglutathione lyase activity
D4A37_RS27150	COG1511	domain protein
D4A37_RS27155	COG0583	DNA-binding transcription factor activity
D4A37_RS27160	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D4A37_RS27165	COG1271	oxidase subunit
D4A37_RS27170	COG1294	oxidase, subunit
D4A37_RS27175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D4A37_RS27185	COG1620	l-lactate permease
D4A37_RS27195	COG2389	metal-binding protein
D4A37_RS27210	COG1368	sulfuric ester hydrolase activity
D4A37_RS27220	COG1388	LysM domain
D4A37_RS27220	COG0791	NLP P60 protein
D4A37_RS27225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4A37_RS27235	COG1215	transferase activity, transferring glycosyl groups
D4A37_RS27240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D4A37_RS27250	COG1388	LysM domain
D4A37_RS27250	COG3584	3D domain protein
D4A37_RS27260	COG4715	Zinc finger, swim domain protein
D4A37_RS27265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D4A37_RS27310	COG0577	efflux transmembrane transporter activity
D4A37_RS27315	COG1136	(ABC) transporter
D4A37_RS27335	COG2271	Major facilitator Superfamily
D4A37_RS27350	COG5002	protein histidine kinase activity
D4A37_RS27355	COG0745	RESPONSE REGULATOR receiver
D4A37_RS27360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D4A37_RS27370	COG1316	TRANSCRIPTIONal
D4A37_RS27400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D4A37_RS27410	COG1086	Polysaccharide biosynthesis protein
D4A37_RS27415	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS27425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D4A37_RS27430	COG1086	Polysaccharide biosynthesis protein
D4A37_RS27440	COG4464	protein tyrosine phosphatase activity
D4A37_RS27445	COG0489	protein tyrosine kinase activity
D4A37_RS27450	COG3944	biosynthesis protein
D4A37_RS27455	COG0489	protein tyrosine kinase activity
D4A37_RS27470	COG1609	Transcriptional regulator
D4A37_RS27480	COG0739	heme binding
D4A37_RS27495	COG3279	Response regulator of the LytR AlgR family
D4A37_RS27505	COG2385	sporulation resulting in formation of a cellular spore
D4A37_RS27520	COG4836	Membrane
D4A37_RS27525	COG1007	ATP synthesis coupled electron transport
D4A37_RS27530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A37_RS27535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A37_RS27545	COG0839	Belongs to the complex I subunit 6 family
D4A37_RS27565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A37_RS27575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A37_RS27580	COG5001	Diguanylate cyclase
D4A37_RS27580	COG3300	MHYT domain
D4A37_RS27600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D4A37_RS27620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D4A37_RS27630	COG0356	it plays a direct role in the translocation of protons across the membrane
D4A37_RS27665	COG0698	ribose 5-phosphate isomerase
D4A37_RS27675	COG2190	(PTS) system
D4A37_RS27680	COG2259	Doxx family
D4A37_RS27685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D4A37_RS27700	COG0009	L-threonylcarbamoyladenylate synthase
D4A37_RS27715	COG2890	protein-(glutamine-N5) methyltransferase activity
D4A37_RS27720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D4A37_RS27725	COG1435	thymidine kinase activity
D4A37_RS27740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D4A37_RS27745	COG1494	fructose-1,6-bisphosphatase
D4A37_RS27765	COG4821	SIS domain
D4A37_RS27770	COG0504	CTP synthase activity
D4A37_RS27785	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS27790	COG1960	acyl-CoA dehydrogenase activity
D4A37_RS27795	COG1250	3-hydroxyacyl-CoA dehydrogenase
D4A37_RS27800	COG0183	Belongs to the thiolase family
D4A37_RS27805	COG2181	nitrate reductase activity
D4A37_RS27805	COG0247	lactate metabolic process
D4A37_RS27810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A37_RS27820	COG3300	MHYT domain
D4A37_RS27820	COG5001	Diguanylate cyclase
D4A37_RS27845	COG2197	response regulator
D4A37_RS27850	COG4585	Histidine kinase
D4A37_RS27855	COG0842	Transport permease protein
D4A37_RS27860	COG1131	(ABC) transporter
D4A37_RS27865	COG0024	Methionine aminopeptidase
D4A37_RS27870	COG2234	aminopeptidase activity
D4A37_RS27900	COG1595	DNA-templated transcription, initiation
D4A37_RS27910	COG4506	Protein conserved in bacteria
D4A37_RS27915	COG1619	proteins homologs of microcin C7 resistance protein MccF
D4A37_RS27940	COG2814	Major facilitator Superfamily
D4A37_RS27945	COG0789	Transcriptional regulator
D4A37_RS27950	COG0584	glycerophosphoryl diester phosphodiesterase
D4A37_RS27955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A37_RS27965	COG1994	Peptidase M50
D4A37_RS27975	COG1078	dGTPase activity
D4A37_RS27980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A37_RS27985	COG1120	ATPase activity
D4A37_RS27990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS27995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A37_RS28000	COG4844	belongs to the
D4A37_RS28015	COG0280	phosphate acetyltransferase
D4A37_RS28030	COG3773	Cell wall hydrolase
D4A37_RS28040	COG2363	Small membrane protein
D4A37_RS28050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D4A37_RS28055	COG2233	PERMEase
D4A37_RS28060	COG0561	phosphatase activity
D4A37_RS28065	COG2814	Major facilitator Superfamily
D4A37_RS28075	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D4A37_RS28080	COG1131	(ABC) transporter
D4A37_RS28085	COG2755	lipolytic protein G-D-S-L family
D4A37_RS28090	COG1609	Transcriptional regulator
D4A37_RS28100	COG0460	homoserine dehydrogenase
D4A37_RS28110	COG2873	o-acetylhomoserine
D4A37_RS28120	COG1011	Hydrolase
D4A37_RS28125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D4A37_RS28140	COG2197	response regulator
D4A37_RS28145	COG2203	Gaf domain
D4A37_RS28145	COG4585	Histidine kinase
D4A37_RS28150	COG0351	phosphomethylpyrimidine kinase
D4A37_RS28155	COG3706	GGDEF domain
D4A37_RS28160	COG2879	small protein
D4A37_RS28165	COG1966	Carbon starvation protein
D4A37_RS28170	COG3279	Response regulator of the LytR AlgR family
D4A37_RS28175	COG0477	Major facilitator Superfamily
D4A37_RS28190	COG0438	transferase activity, transferring glycosyl groups
D4A37_RS28205	COG0840	transmembrane signaling receptor activity
D4A37_RS28215	COG1607	acyl-coa hydrolase
D4A37_RS28230	COG0488	(ABC) transporter
D4A37_RS28240	COG1309	transcriptional regulator
D4A37_RS28245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D4A37_RS28250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4A37_RS28250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4A37_RS28255	COG0628	permease
D4A37_RS28265	COG1380	Effector of murein hydrolase LrgA
D4A37_RS28270	COG3279	Response regulator of the LytR AlgR family
D4A37_RS28275	COG3275	phosphorelay sensor kinase activity
D4A37_RS28280	COG2814	Major facilitator Superfamily
D4A37_RS28285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D4A37_RS28290	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D4A37_RS28315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D4A37_RS28320	COG1272	protein, Hemolysin III
D4A37_RS28340	COG1164	Oligoendopeptidase f
D4A37_RS28360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D4A37_RS28365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D4A37_RS28370	COG4853	Protein conserved in bacteria
D4A37_RS28375	COG4863	YycH protein
D4A37_RS28380	COG5002	protein histidine kinase activity
D4A37_RS28385	COG0745	RESPONSE REGULATOR receiver
D4A37_RS28415	COG0305	Participates in initiation and elongation during chromosome replication
D4A37_RS28425	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D4A37_RS28430	COG4241	membrane
D4A37_RS28440	COG0629	single-stranded DNA binding
D4A37_RS28450	COG0012	GTP binding
D4A37_RS28455	COG4481	Protein conserved in bacteria
D4A37_RS28460	COG0668	transmembrane transport
D4A37_RS28470	COG1475	DNA binding
D4A37_RS28475	COG1192	Involved in chromosome partitioning
D4A37_RS28500	COG1847	R3H domain protein
D4A37_RS28505	COG0706	membrane insertase activity
D4A37_RS28515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D4A37_RS28565	COG0741	lytic transglycosylase activity
D4A37_RS28565	COG0739	heme binding
D4A37_RS28565	COG1196	nuclear chromosome segregation
D4A37_RS28610	COG3409	Peptidoglycan-binding domain 1 protein
D4A37_RS28610	COG5632	N-Acetylmuramoyl-L-alanine amidase
D4A37_RS28700	COG2404	hydrolase activity, acting on ester bonds
D4A37_RS28720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4A37_RS28730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4A37_RS28745	COG1328	CTP reductase activity
D4A37_RS28750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D4A37_RS28780	COG4112	unkown
D4A37_RS28785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D4A37_RS28805	COG0587	DNA-directed DNA polymerase activity
D4A37_RS28810	COG4676	Protein conserved in bacteria
D4A37_RS28850	COG2304	oxidoreductase activity
D4A37_RS28915	COG0861	Integral membrane protein TerC family
D4A37_RS29020	COG1388	LysM domain
D4A37_RS29020	COG3584	3D domain protein
D4A37_RS29260	COG0210	DNA helicase
D4A37_RS29285	COG0776	regulation of translation
D4A37_RS29340	COG4373	Mu-like prophage FluMu protein gp28