locus-tag	class	description
BK049_RS00020	COG4974	Belongs to the 'phage' integrase family
BK049_RS00025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BK049_RS00030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK049_RS00040	COG4550	Control of competence regulator ComK, YlbF/YmcA
BK049_RS00045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK049_RS00050	COG0156	8-amino-7-oxononanoate synthase activity
BK049_RS00055	COG1063	alcohol dehydrogenase
BK049_RS00060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BK049_RS00065	COG2359	stage V sporulation protein S
BK049_RS00070	COG1692	metallophosphoesterase
BK049_RS00075	COG1418	mRNA catabolic process
BK049_RS00080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BK049_RS00085	COG1546	Belongs to the CinA family
BK049_RS00085	COG1058	Belongs to the CinA family
BK049_RS00090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BK049_RS00095	COG1426	Protein conserved in bacteria
BK049_RS00110	COG0300	oxidoreductase activity
BK049_RS00115	COG1033	growth of symbiont in host cell
BK049_RS00115	COG2409	Drug exporters of the RND superfamily
BK049_RS00125	COG0612	Peptidase, M16
BK049_RS00130	COG0612	Peptidase, M16
BK049_RS00135	COG2409	Drug exporters of the RND superfamily
BK049_RS00135	COG1033	growth of symbiont in host cell
BK049_RS00140	COG2814	Major facilitator Superfamily
BK049_RS00145	COG2188	Transcriptional regulator
BK049_RS00150	COG4980	gas vesicle protein
BK049_RS00150	COG1674	ftsk spoiiie
BK049_RS00160	COG0740	serine-type endopeptidase activity
BK049_RS00165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK049_RS00175	COG0527	aspartate kinase activity
BK049_RS00180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BK049_RS00185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BK049_RS00190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK049_RS00195	COG1873	PFAM PRC-barrel domain
BK049_RS00205	COG0612	Peptidase, M16
BK049_RS00210	COG0726	polysaccharide deacetylase
BK049_RS00215	COG1185	polyribonucleotide nucleotidyltransferase activity
BK049_RS00220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BK049_RS00225	COG0196	riboflavin kinase activity
BK049_RS00230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BK049_RS00235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BK049_RS00240	COG1550	Protein conserved in bacteria
BK049_RS00245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK049_RS00250	COG1358	cellular component organization or biogenesis
BK049_RS00255	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BK049_RS00260	COG0195	Participates in both transcription termination and antitermination
BK049_RS00265	COG0779	Required for maturation of 30S ribosomal subunits
BK049_RS00275	COG3693	PFAM glycoside hydrolase, family 10
BK049_RS00290	COG2176	DNA-directed DNA polymerase activity
BK049_RS00295	COG0442	prolyl-tRNA aminoacylation
BK049_RS00300	COG0750	zinc metalloprotease
BK049_RS00305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BK049_RS00310	COG4589	Belongs to the CDS family
BK049_RS00315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK049_RS00320	COG0233	cytoplasmic translational termination
BK049_RS00325	COG0528	UMP kinase activity
BK049_RS00330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK049_RS00345	COG1191	sigma factor activity
BK049_RS00355	COG1776	CheC inhibitor of MCP methylation
BK049_RS00360	COG0835	chemotaxis
BK049_RS00365	COG0643	Histidine kinase
BK049_RS00365	COG2198	Histidine kinase
BK049_RS00370	COG2201	protein-glutamate methylesterase activity
BK049_RS00375	COG0455	bacterial-type flagellum organization
BK049_RS00380	COG1419	protein localization to endoplasmic reticulum
BK049_RS00385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BK049_RS00390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BK049_RS00395	COG1684	flagellar biosynthetic protein fliR
BK049_RS00400	COG1987	bacterial-type flagellum assembly
BK049_RS00405	COG1338	Plays a role in the flagellum-specific transport system
BK049_RS00410	COG3190	flagellar
BK049_RS00415	COG2201	protein-glutamate methylesterase activity
BK049_RS00420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BK049_RS00420	COG1776	CheC inhibitor of MCP methylation
BK049_RS00425	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BK049_RS00430	COG1580	Controls the rotational direction of flagella during chemotaxis
BK049_RS00435	COG1582	Flagellar protein (FlbD)
BK049_RS00440	COG4786	Flagellar basal body rod
BK049_RS00445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BK049_RS00450	COG3144	bacterial-type flagellum assembly
BK049_RS00460	COG2882	bacterial-type flagellum organization
BK049_RS00465	COG1157	protein secretion by the type III secretion system
BK049_RS00470	COG1317	bacterial-type flagellum organization
BK049_RS00475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BK049_RS00480	COG1766	The M ring may be actively involved in energy transduction
BK049_RS00485	COG1677	Flagellar hook-basal body complex protein FliE
BK049_RS00490	COG1558	bacterial-type flagellum-dependent cell motility
BK049_RS00495	COG1815	bacterial-type flagellum-dependent cell motility
BK049_RS00500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BK049_RS00505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BK049_RS00510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BK049_RS00515	COG4974	Belongs to the 'phage' integrase family
BK049_RS00520	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BK049_RS00525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK049_RS00530	COG0758	DNA mediated transformation
BK049_RS00535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK049_RS00540	COG0045	succinate-CoA ligase (ADP-forming) activity
BK049_RS00545	COG2257	FlhB HrpN YscU SpaS Family
BK049_RS00555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK049_RS00560	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BK049_RS00565	COG0335	large ribosomal subunit rRNA binding
BK049_RS00570	COG0336	Belongs to the RNA methyltransferase TrmD family
BK049_RS00575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK049_RS00585	COG1837	Belongs to the UPF0109 family
BK049_RS00590	COG0228	four-way junction DNA binding
BK049_RS00595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK049_RS00600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BK049_RS00605	COG0552	protein localization to endoplasmic reticulum
BK049_RS00610	COG1196	nuclear chromosome segregation
BK049_RS00620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK049_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS00630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BK049_RS00635	COG0416	fatty acid biosynthetic process
BK049_RS00640	COG1349	DNA-binding transcription factor activity
BK049_RS00645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BK049_RS00650	COG1760	l-serine dehydratase
BK049_RS00655	COG1760	l-serine dehydratase
BK049_RS00660	COG1461	Dihydroxyacetone kinase
BK049_RS00665	COG1302	Protein conserved in bacteria
BK049_RS00670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BK049_RS00680	COG1564	THIamine pyrophosphokinase
BK049_RS00685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK049_RS00690	COG1162	GTPase activity
BK049_RS00695	COG0515	serine threonine protein kinase
BK049_RS00695	COG2815	serine threonine protein kinase
BK049_RS00700	COG0631	protein serine/threonine phosphatase activity
BK049_RS00705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BK049_RS00710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BK049_RS00710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BK049_RS00715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BK049_RS00720	COG0242	peptide deformylase activity
BK049_RS00725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BK049_RS00730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BK049_RS00735	COG1758	RNA polymerase activity
BK049_RS00740	COG0194	GDP metabolic process
BK049_RS00745	COG2052	Domain of unknown function (DUF370)
BK049_RS00750	COG1561	YicC-like family, N-terminal region
BK049_RS00755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK049_RS00765	COG1648	precorrin-2 dehydrogenase activity
BK049_RS00770	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BK049_RS00775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BK049_RS00780	COG0529	Catalyzes the synthesis of activated sulfate
BK049_RS00785	COG2046	Belongs to the sulfate adenylyltransferase family
BK049_RS00790	COG0306	phosphate transporter
BK049_RS00795	COG0175	sulfate reduction
BK049_RS00800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BK049_RS00805	COG0284	orotidine-5'-phosphate decarboxylase activity
BK049_RS00810	COG0167	dihydroorotate dehydrogenase activity
BK049_RS00815	COG0543	2 iron, 2 sulfur cluster binding
BK049_RS00820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BK049_RS00825	COG0505	Belongs to the CarA family
BK049_RS00830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BK049_RS00835	COG0540	Belongs to the ATCase OTCase family
BK049_RS00840	COG2233	PERMEase
BK049_RS00845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BK049_RS00850	COG0564	pseudouridine synthase activity
BK049_RS00855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK049_RS00860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BK049_RS00865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BK049_RS00870	COG3599	regulation of cell shape
BK049_RS00875	COG2302	S4 RNA-binding domain
BK049_RS00880	COG0762	integral membrane protein
BK049_RS00885	COG1799	cell septum assembly
BK049_RS00890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BK049_RS00895	COG1496	oxidoreductase activity
BK049_RS00900	COG1873	PFAM PRC-barrel domain
BK049_RS00905	COG1119	ATPase activity
BK049_RS00915	COG3732	PTS system glucitol sorbitol-specific
BK049_RS00920	COG3730	PTS system glucitol sorbitol-specific
BK049_RS00935	COG2390	Transcriptional regulator
BK049_RS00940	COG1191	sigma factor activity
BK049_RS00945	COG1191	sigma factor activity
BK049_RS00955	COG4412	M6 family metalloprotease domain protein
BK049_RS00955	COG1404	Belongs to the peptidase S8 family
BK049_RS00960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK049_RS00965	COG0849	cell division
BK049_RS00970	COG3856	small basic protein
BK049_RS00975	COG3879	Bacterial protein of unknown function (DUF881)
BK049_RS00980	COG3879	Bacterial protein of unknown function (DUF881)
BK049_RS00985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BK049_RS00990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BK049_RS00995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK049_RS01000	COG0772	Belongs to the SEDS family
BK049_RS01005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK049_RS01010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK049_RS01015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BK049_RS01020	COG0768	penicillin binding
BK049_RS01025	COG0768	penicillin binding
BK049_RS01030	COG4839	cell division protein FtsL
BK049_RS01035	COG0275	rRNA processing
BK049_RS01040	COG2001	Belongs to the MraZ family
BK049_RS01045	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BK049_RS01050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BK049_RS01055	COG0454	-acetyltransferase
BK049_RS01065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BK049_RS01070	COG1399	metal-binding, possibly nucleic acid-binding protein
BK049_RS01080	COG3480	Lon protease (S16) C-terminal proteolytic domain
BK049_RS01085	COG1752	Esterase of the alpha-beta hydrolase superfamily
BK049_RS01090	COG3314	Sporulation integral membrane protein YlbJ
BK049_RS01095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BK049_RS01100	COG0742	ribosomal rna small subunit methyltransferase
BK049_RS01105	COG4471	UPF0298 protein
BK049_RS01110	COG3679	Belongs to the UPF0342 family
BK049_RS01130	COG2340	Cysteine-rich secretory protein family
BK049_RS01135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BK049_RS01145	COG3336	cytochrome c oxidase
BK049_RS01150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BK049_RS01155	COG1845	cytochrome c oxidase, subunit III
BK049_RS01160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BK049_RS01165	COG2010	Cytochrome c
BK049_RS01165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BK049_RS01170	COG0109	protoheme IX farnesyltransferase activity
BK049_RS01175	COG1612	heme a metabolic process
BK049_RS01180	COG0415	Belongs to the DNA photolyase family
BK049_RS01185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BK049_RS01190	COG0772	Belongs to the SEDS family
BK049_RS01195	COG4838	Belongs to the UPF0358 family
BK049_RS01200	COG2066	Belongs to the glutaminase family
BK049_RS01205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BK049_RS01210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BK049_RS01220	COG4896	Protein conserved in bacteria
BK049_RS01230	COG1217	gtp-binding protein TYPA
BK049_RS01245	COG0483	inositol monophosphate 1-phosphatase activity
BK049_RS01255	COG4493	Belongs to the UPF0637 family
BK049_RS01260	COG4476	Belongs to the UPF0223 family
BK049_RS01265	COG1982	Orn Lys Arg decarboxylase major
BK049_RS01270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK049_RS01280	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK049_RS01285	COG0022	dehydrogenase e1 component
BK049_RS01290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BK049_RS01305	COG0242	peptide deformylase activity
BK049_RS01310	COG0561	phosphatase activity
BK049_RS01315	COG5503	Protein of unknown function (DUF1447)
BK049_RS01320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK049_RS01325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BK049_RS01330	COG0569	domain protein
BK049_RS01335	COG2105	PFAM AIG2 family protein
BK049_RS01335	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BK049_RS01340	COG3852	Histidine kinase
BK049_RS01345	COG2002	toxin-antitoxin pair type II binding
BK049_RS01350	COG1077	Cell shape determining protein MreB Mrl
BK049_RS01355	COG2309	aminopeptidase activity
BK049_RS01360	COG0488	(ABC) transporter
BK049_RS01375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK049_RS01375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK049_RS01375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS01380	COG1105	Belongs to the carbohydrate kinase PfkB family
BK049_RS01385	COG1349	DNA-binding transcription factor activity
BK049_RS01390	COG0577	efflux transmembrane transporter activity
BK049_RS01395	COG1136	(ABC) transporter
BK049_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BK049_RS01415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BK049_RS01420	COG0314	molybdopterin synthase activity
BK049_RS01425	COG1763	Mo-molybdopterin cofactor biosynthetic process
BK049_RS01430	COG0303	'Molybdopterin
BK049_RS01435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BK049_RS01440	COG0746	molybdenum cofactor guanylyltransferase activity
BK049_RS01455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS01460	COG0450	alkyl hydroperoxide reductase
BK049_RS01465	COG0668	transmembrane transport
BK049_RS01475	COG1473	amidohydrolase
BK049_RS01480	COG2171	N-acyltransferase activity
BK049_RS01485	COG0716	FMN binding
BK049_RS01495	COG0716	FMN binding
BK049_RS01505	COG0583	DNA-binding transcription factor activity
BK049_RS01510	COG0517	IMP dehydrogenase activity
BK049_RS01520	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BK049_RS01525	COG4703	Protein of unknown function (DUF1797)
BK049_RS01530	COG3546	catalase activity
BK049_RS01535	COG2200	EAL domain
BK049_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS01545	COG1408	metallophosphoesterase
BK049_RS01550	COG1376	ErfK ybiS ycfS ynhG family protein
BK049_RS01555	COG2814	Major facilitator Superfamily
BK049_RS01565	COG0457	Tetratricopeptide repeat
BK049_RS01585	COG0784	Response regulator, receiver
BK049_RS01585	COG0835	chemotaxis
BK049_RS01595	COG1714	RDD family
BK049_RS01600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BK049_RS01605	COG0436	Aminotransferase
BK049_RS01610	COG4191	Histidine kinase
BK049_RS01615	COG0768	penicillin binding
BK049_RS01620	COG2340	Cysteine-rich secretory protein family
BK049_RS01625	COG2084	Dehydrogenase
BK049_RS01635	COG0840	transmembrane signaling receptor activity
BK049_RS01640	COG1533	DNA photolyase activity
BK049_RS01650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK049_RS01655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS01660	COG2190	(PTS) system
BK049_RS01660	COG1263	PTS System
BK049_RS01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS01665	COG3711	transcriptional antiterminator
BK049_RS01670	COG1609	Transcriptional regulator
BK049_RS01675	COG0006	proline dipeptidase activity
BK049_RS01680	COG2217	Heavy metal translocating P-type atpase
BK049_RS01685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS01690	COG2244	polysaccharide biosynthetic process
BK049_RS01695	COG3773	Cell wall hydrolase
BK049_RS01705	COG4873	Protein conserved in bacteria
BK049_RS01720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BK049_RS01725	COG0602	queuosine metabolic process
BK049_RS01730	COG0720	synthase
BK049_RS01735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BK049_RS01740	COG3949	Membrane
BK049_RS01745	COG0542	response to heat
BK049_RS01755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BK049_RS01760	COG1360	Flagellar Motor Protein
BK049_RS01765	COG1846	Transcriptional regulator
BK049_RS01770	COG3852	Histidine kinase
BK049_RS01780	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BK049_RS01785	COG0235	Class ii aldolase
BK049_RS01790	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BK049_RS01795	COG1850	ribulose-bisphosphate carboxylase activity
BK049_RS01800	COG0436	Aminotransferase
BK049_RS01805	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BK049_RS01810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BK049_RS01815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BK049_RS01820	COG5002	protein histidine kinase activity
BK049_RS01825	COG3594	Acyltransferase
BK049_RS01835	COG2323	membrane
BK049_RS01840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BK049_RS01845	COG0501	Belongs to the peptidase M48B family
BK049_RS01865	COG1191	sigma factor activity
BK049_RS01870	COG0861	Integral membrane protein TerC family
BK049_RS01875	COG0586	Pfam SNARE associated Golgi protein
BK049_RS01880	COG5001	Diguanylate cyclase
BK049_RS01880	COG3300	MHYT domain
BK049_RS01885	COG1846	Transcriptional regulator
BK049_RS01895	COG0789	Transcriptional regulator
BK049_RS01905	COG2239	Acts as a magnesium transporter
BK049_RS01910	COG3212	peptidase
BK049_RS01915	COG3212	peptidase
BK049_RS01920	COG5002	protein histidine kinase activity
BK049_RS01920	COG3850	Histidine kinase
BK049_RS01925	COG0745	RESPONSE REGULATOR receiver
BK049_RS01930	COG1404	Belongs to the peptidase S8 family
BK049_RS01935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BK049_RS01940	COG0590	tRNA wobble adenosine to inosine editing
BK049_RS01945	COG1764	response to oxidative stress
BK049_RS01950	COG1846	Transcriptional regulator
BK049_RS01955	COG1764	response to oxidative stress
BK049_RS01965	COG0457	Tetratricopeptide repeat
BK049_RS01970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BK049_RS01975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BK049_RS01980	COG0788	formyltetrahydrofolate deformylase activity
BK049_RS01990	COG2076	Multidrug Resistance protein
BK049_RS01995	COG2076	Multidrug Resistance protein
BK049_RS02010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK049_RS02025	COG1695	Transcriptional regulator
BK049_RS02030	COG1607	acyl-coa hydrolase
BK049_RS02035	COG1834	amidinotransferase
BK049_RS02040	COG4608	Belongs to the ABC transporter superfamily
BK049_RS02045	COG0791	NLP P60 protein
BK049_RS02050	COG4948	Mandelate Racemase Muconate Lactonizing
BK049_RS02055	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK049_RS02060	COG4166	transmembrane transport
BK049_RS02065	COG0444	Belongs to the ABC transporter superfamily
BK049_RS02070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK049_RS02075	COG0601	transmembrane transport
BK049_RS02080	COG2362	D-Aminopeptidase
BK049_RS02085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK049_RS02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK049_RS02095	COG0346	lactoylglutathione lyase activity
BK049_RS02100	COG0531	amino acid
BK049_RS02110	COG2390	Transcriptional regulator
BK049_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS02125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK049_RS02135	COG0022	dehydrogenase e1 component
BK049_RS02135	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK049_RS02140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BK049_RS02145	COG1063	alcohol dehydrogenase
BK049_RS02160	COG3775	system Galactitol-specific IIC component
BK049_RS02170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BK049_RS02175	COG4208	sulfate ABC transporter
BK049_RS02185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BK049_RS02190	COG0405	Gamma-glutamyltransferase
BK049_RS02200	COG1392	Phosphate transport regulator
BK049_RS02205	COG0306	phosphate transporter
BK049_RS02220	COG3409	Peptidoglycan-binding domain 1 protein
BK049_RS02220	COG5632	N-Acetylmuramoyl-L-alanine amidase
BK049_RS02225	COG2856	Zn peptidase
BK049_RS02230	COG4195	phage-related replication protein
BK049_RS02250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BK049_RS02255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BK049_RS02260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK049_RS02275	COG0457	Tetratricopeptide repeat
BK049_RS02305	COG0626	cystathionine gamma-synthase activity
BK049_RS02310	COG0626	cystathionine gamma-synthase activity
BK049_RS02315	COG2382	esterase
BK049_RS02320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BK049_RS02325	COG2153	protein acetylation
BK049_RS02335	COG0210	DNA helicase
BK049_RS02390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BK049_RS02395	COG0351	phosphomethylpyrimidine kinase
BK049_RS02400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BK049_RS02405	COG2022	thiamine diphosphate biosynthetic process
BK049_RS02410	COG2104	thiamine diphosphate biosynthetic process
BK049_RS02420	COG0352	thiamine-phosphate diphosphorylase activity
BK049_RS02425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BK049_RS02430	COG0475	glutathione-regulated potassium exporter activity
BK049_RS02430	COG0569	domain protein
BK049_RS02435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BK049_RS02440	COG0564	pseudouridine synthase activity
BK049_RS02445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BK049_RS02450	COG2357	RelA SpoT domain protein
BK049_RS02460	COG4116	CYTH
BK049_RS02465	COG0741	lytic transglycosylase activity
BK049_RS02470	COG2346	COG2346, Truncated hemoglobins
BK049_RS02475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BK049_RS02480	COG1164	Oligoendopeptidase f
BK049_RS02490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK049_RS02495	COG4862	establishment of competence for transformation
BK049_RS02500	COG0861	Integral membrane protein TerC family
BK049_RS02505	COG1393	Belongs to the ArsC family
BK049_RS02510	COG0456	acetyltransferase
BK049_RS02520	COG4608	Belongs to the ABC transporter superfamily
BK049_RS02525	COG0444	Belongs to the ABC transporter superfamily
BK049_RS02530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK049_RS02535	COG0601	transmembrane transport
BK049_RS02540	COG4166	transmembrane transport
BK049_RS02545	COG0180	Tryptophanyl-tRNA synthetase
BK049_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK049_RS02570	COG0601	transmembrane transport
BK049_RS02580	COG4608	Belongs to the ABC transporter superfamily
BK049_RS02585	COG0444	Belongs to the ABC transporter superfamily
BK049_RS02590	COG5504	Zn-dependent protease
BK049_RS02595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BK049_RS02600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BK049_RS02615	COG1744	ABC transporter substrate-binding protein PnrA-like
BK049_RS02625	COG2267	carboxylic ester hydrolase activity
BK049_RS02640	COG2814	Major facilitator Superfamily
BK049_RS02650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BK049_RS02655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BK049_RS02660	COG0505	Belongs to the CarA family
BK049_RS02665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BK049_RS02670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BK049_RS02675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BK049_RS02680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BK049_RS02685	COG2271	Major facilitator Superfamily
BK049_RS02695	COG2151	metal-sulfur cluster biosynthetic enzyme
BK049_RS02700	COG1073	alpha beta
BK049_RS02705	COG0561	phosphatase activity
BK049_RS02725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK049_RS02730	COG1307	EDD domain protein, DegV family
BK049_RS02735	COG2801	Transposase and inactivated derivatives
BK049_RS02745	COG0840	transmembrane signaling receptor activity
BK049_RS02750	COG1744	ABC transporter substrate-binding protein PnrA-like
BK049_RS02755	COG2996	Protein conserved in bacteria
BK049_RS02760	COG1666	GTP binding
BK049_RS02765	COG0646	methionine synthase
BK049_RS02765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BK049_RS02770	COG0646	methionine synthase
BK049_RS02770	COG1410	methionine synthase
BK049_RS02805	COG0076	glutamate decarboxylase activity
BK049_RS02830	COG1917	Cupin 2, conserved barrel domain protein
BK049_RS02830	COG2207	Transcriptional regulator
BK049_RS02835	COG0534	Mate efflux family protein
BK049_RS02840	COG1562	ergosterol biosynthetic process
BK049_RS02855	COG0367	asparagine synthase
BK049_RS02870	COG0179	Fumarylacetoacetate (FAA) hydrolase
BK049_RS02880	COG5337	Spore coat protein CotH
BK049_RS02920	COG1403	HNH endonuclease
BK049_RS02925	COG0419	ATPase involved in DNA repair
BK049_RS02930	COG0420	3'-5' exonuclease activity
BK049_RS02935	COG1074	ATP-dependent DNA helicase activity
BK049_RS02940	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BK049_RS02945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BK049_RS02950	COG2259	Doxx family
BK049_RS02955	COG0501	Belongs to the peptidase M48B family
BK049_RS02965	COG3180	Ammonia monooxygenase
BK049_RS02970	COG0681	Belongs to the peptidase S26 family
BK049_RS02975	COG0398	Pfam SNARE associated Golgi protein
BK049_RS02990	COG1316	TRANSCRIPTIONal
BK049_RS02995	COG4607	ABC-type enterochelin transport system periplasmic component
BK049_RS03000	COG4604	ABC transporter, ATP-binding protein
BK049_RS03005	COG4605	iron ion homeostasis
BK049_RS03010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS03015	COG2732	(Barnase) inhibitor
BK049_RS03020	COG2814	Major facilitator Superfamily
BK049_RS03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK049_RS03035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK049_RS03040	COG2964	Protein conserved in bacteria
BK049_RS03045	COG4903	ComK protein
BK049_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS03060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BK049_RS03060	COG0723	plastoquinol--plastocyanin reductase activity
BK049_RS03065	COG0840	transmembrane signaling receptor activity
BK049_RS03070	COG0406	alpha-ribazole phosphatase activity
BK049_RS03075	COG1404	Belongs to the peptidase S8 family
BK049_RS03080	COG0501	Belongs to the peptidase M48B family
BK049_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
BK049_RS03095	COG0095	Lipoate-protein ligase
BK049_RS03100	COG1234	tRNA 3'-trailer cleavage
BK049_RS03110	COG1301	dicarboxylic acid transport
BK049_RS03115	COG1363	Peptidase, m42
BK049_RS03125	COG1511	domain protein
BK049_RS03130	COG1309	transcriptional regulator
BK049_RS03135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BK049_RS03140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BK049_RS03145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BK049_RS03150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK049_RS03155	COG2329	Antibiotic biosynthesis monooxygenase
BK049_RS03165	COG1473	amidohydrolase
BK049_RS03175	COG4473	ABC transporter
BK049_RS03180	COG1131	(ABC) transporter
BK049_RS03185	COG0537	adenosine 5'-monophosphoramidase activity
BK049_RS03190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BK049_RS03205	COG4980	gas vesicle protein
BK049_RS03210	COG1846	Transcriptional regulator
BK049_RS03230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BK049_RS03240	COG3481	metal-dependent phosphohydrolase, HD sub domain
BK049_RS03245	COG4717	serine-type aminopeptidase activity
BK049_RS03250	COG0420	3'-5' exonuclease activity
BK049_RS03260	COG1024	Enoyl-CoA hydratase
BK049_RS03270	COG0490	domain, Protein
BK049_RS03275	COG0475	glutathione-regulated potassium exporter activity
BK049_RS03285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK049_RS03290	COG0561	phosphatase activity
BK049_RS03295	COG3679	Belongs to the UPF0342 family
BK049_RS03300	COG4399	Belongs to the UPF0754 family
BK049_RS03305	COG0189	ligase activity
BK049_RS03310	COG0189	ligase activity
BK049_RS03320	COG2508	Transcriptional regulator
BK049_RS03325	COG3842	ATPase activity
BK049_RS03335	COG0702	epimerase
BK049_RS03340	COG2801	Transposase and inactivated derivatives
BK049_RS03350	COG1132	(ABC) transporter
BK049_RS03355	COG1132	(ABC) transporter
BK049_RS03360	COG0589	response to stress
BK049_RS03365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK049_RS03370	COG0726	polysaccharide deacetylase
BK049_RS03375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BK049_RS03380	COG0668	transmembrane transport
BK049_RS03385	COG0584	glycerophosphoryl diester phosphodiesterase
BK049_RS03390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BK049_RS03405	COG1253	flavin adenine dinucleotide binding
BK049_RS03410	COG0789	Transcriptional regulator
BK049_RS03415	COG1253	flavin adenine dinucleotide binding
BK049_RS03420	COG0204	Acyl-transferase
BK049_RS03425	COG1595	DNA-templated transcription, initiation
BK049_RS03440	COG0531	amino acid
BK049_RS03445	COG0791	NLP P60 protein
BK049_RS03445	COG1388	LysM domain
BK049_RS03450	COG1785	Belongs to the alkaline phosphatase family
BK049_RS03455	COG2719	SpoVR family
BK049_RS03460	COG1017	nitric oxide dioxygenase activity
BK049_RS03460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BK049_RS03465	COG1959	2 iron, 2 sulfur cluster binding
BK049_RS03470	COG0753	catalase activity
BK049_RS03485	COG2197	response regulator
BK049_RS03490	COG4585	Histidine kinase
BK049_RS03490	COG2203	Gaf domain
BK049_RS03495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK049_RS03500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BK049_RS03505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BK049_RS03510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BK049_RS03515	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BK049_RS03520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BK049_RS03525	COG3835	regulator
BK049_RS03545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK049_RS03545	COG3153	acetyltransferase
BK049_RS03550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BK049_RS03560	COG0564	pseudouridine synthase activity
BK049_RS03565	COG3764	Sortase (surface protein transpeptidase)
BK049_RS03570	COG4085	toxin activity
BK049_RS03570	COG1525	nuclease
BK049_RS03570	COG0737	Belongs to the 5'-nucleotidase family
BK049_RS03575	COG5002	protein histidine kinase activity
BK049_RS03580	COG5577	PFAM Coat F domain
BK049_RS03605	COG3706	GGDEF domain
BK049_RS03610	COG1278	Cold shock
BK049_RS03620	COG0655	NAD(P)H dehydrogenase (quinone) activity
BK049_RS03625	COG2814	Major facilitator Superfamily
BK049_RS03630	COG1566	PFAM secretion protein HlyD family protein
BK049_RS03635	COG2718	Belongs to the UPF0229 family
BK049_RS03640	COG2766	serine protein kinase
BK049_RS03645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BK049_RS03655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK049_RS03660	COG3382	B3 4 domain protein
BK049_RS03690	COG1131	(ABC) transporter
BK049_RS03700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS03705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BK049_RS03710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BK049_RS03715	COG1116	anion transmembrane transporter activity
BK049_RS03725	COG2873	o-acetylhomoserine
BK049_RS03730	COG0681	Belongs to the peptidase S26 family
BK049_RS03735	COG1368	sulfuric ester hydrolase activity
BK049_RS03880	COG0735	belongs to the Fur family
BK049_RS03885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BK049_RS03890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BK049_RS03895	COG4129	membrane
BK049_RS03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK049_RS03905	COG0601	transmembrane transport
BK049_RS03910	COG0747	negative chemotaxis
BK049_RS03915	COG4608	Belongs to the ABC transporter superfamily
BK049_RS03920	COG0444	Belongs to the ABC transporter superfamily
BK049_RS03925	COG1132	(ABC) transporter
BK049_RS03930	COG3557	Belongs to the UPF0374 family
BK049_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS03955	COG1194	a g-specific adenine glycosylase
BK049_RS03960	COG1988	membrane-bound metal-dependent
BK049_RS03970	COG1191	sigma factor activity
BK049_RS03975	COG2140	Oxalate decarboxylase
BK049_RS03990	COG4485	Bacterial membrane protein, YfhO
BK049_RS03995	COG0463	Glycosyl transferase, family 2
BK049_RS04015	COG2137	regulation of response to DNA damage stimulus
BK049_RS04020	COG1090	epimerase
BK049_RS04035	COG0778	Nitroreductase
BK049_RS04055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BK049_RS04055	COG0392	lysyltransferase activity
BK049_RS04060	COG1846	Transcriptional regulator
BK049_RS04085	COG1742	UPF0060 membrane protein
BK049_RS04090	COG1132	(ABC) transporter
BK049_RS04095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BK049_RS04100	COG1917	Cupin 2, conserved barrel domain protein
BK049_RS04100	COG2207	Transcriptional regulator
BK049_RS04105	COG0492	ferredoxin-NADP+ reductase activity
BK049_RS04110	COG2755	lipolytic protein G-D-S-L family
BK049_RS04115	COG4637	Psort location Cytoplasmic, score
BK049_RS04125	COG1309	transcriptional regulator
BK049_RS04130	COG2076	Multidrug Resistance protein
BK049_RS04135	COG2076	Multidrug Resistance protein
BK049_RS04190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK049_RS04195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BK049_RS04205	COG0598	Magnesium transport protein CorA
BK049_RS04215	COG0726	polysaccharide deacetylase
BK049_RS04225	COG0535	radical SAM domain protein
BK049_RS04230	COG0668	transmembrane transport
BK049_RS04235	COG0217	transcriptional regulatory protein
BK049_RS04245	COG0387	Pfam Sodium calcium exchanger
BK049_RS04255	COG0477	Major facilitator Superfamily
BK049_RS04260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK049_RS04265	COG2801	Transposase and inactivated derivatives
BK049_RS04275	COG1295	ribonuclease BN
BK049_RS04280	COG4980	gas vesicle protein
BK049_RS04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK049_RS04290	COG1115	amino acid carrier protein
BK049_RS04295	COG4840	Belongs to the UPF0435 family
BK049_RS04300	COG0693	protein deglycase activity
BK049_RS04305	COG0737	Belongs to the 5'-nucleotidase family
BK049_RS04315	COG2188	Transcriptional regulator
BK049_RS04320	COG0366	Alpha amylase catalytic
BK049_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS04325	COG1263	PTS System
BK049_RS04340	COG0076	glutamate decarboxylase activity
BK049_RS04345	COG1368	sulfuric ester hydrolase activity
BK049_RS04355	COG1263	PTS System
BK049_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS04360	COG0024	Methionine aminopeptidase
BK049_RS04370	COG2258	MOSC domain
BK049_RS04375	COG1254	Belongs to the acylphosphatase family
BK049_RS04380	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BK049_RS04400	COG2851	Citrate transporter
BK049_RS04405	COG3181	Tripartite tricarboxylate transporter family receptor
BK049_RS04410	COG4565	transcriptional regulatory protein
BK049_RS04415	COG3290	protein histidine kinase activity
BK049_RS04440	COG2130	NADP-dependent
BK049_RS04445	COG0513	Belongs to the DEAD box helicase family
BK049_RS04450	COG0488	(ABC) transporter
BK049_RS04455	COG2814	Major facilitator Superfamily
BK049_RS04460	COG1469	GTP cyclohydrolase I activity
BK049_RS04465	COG0488	(ABC) transporter
BK049_RS04470	COG0463	Glycosyl transferase, family 2
BK049_RS04470	COG0457	Tetratricopeptide repeat
BK049_RS04475	COG0531	amino acid
BK049_RS04490	COG0071	Belongs to the small heat shock protein (HSP20) family
BK049_RS04505	COG0471	metal ion transport
BK049_RS04515	COG2223	nitrite transmembrane transporter activity
BK049_RS04520	COG1442	glycosyl transferase family 8
BK049_RS04525	COG1216	Glycosyl transferase, family 2
BK049_RS04530	COG1442	glycosyl transferase family 8
BK049_RS04535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK049_RS04540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BK049_RS04570	COG2211	Major facilitator Superfamily
BK049_RS04580	COG1486	melibiose metabolic process
BK049_RS04610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BK049_RS04615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK049_RS04620	COG1597	lipid kinase activity
BK049_RS04625	COG1957	nucleoside hydrolase
BK049_RS04630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BK049_RS04635	COG1309	transcriptional regulator
BK049_RS04640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK049_RS04645	COG0154	amidase activity
BK049_RS04650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK049_RS04655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK049_RS04660	COG1285	pathogenesis
BK049_RS04665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BK049_RS04670	COG4851	CamS sex pheromone cAM373 precursor
BK049_RS04675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BK049_RS04680	COG0210	DNA helicase
BK049_RS04685	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BK049_RS04695	COG0069	glutamate synthase activity
BK049_RS04700	COG4496	protein, YerC YecD
BK049_RS04705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BK049_RS04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK049_RS04720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BK049_RS04725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BK049_RS04730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BK049_RS04755	COG0151	Belongs to the GarS family
BK049_RS04760	COG0138	bifunctional purine biosynthesis protein purh
BK049_RS04765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BK049_RS04770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BK049_RS04775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BK049_RS04780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK049_RS04785	COG0047	phosphoribosylformylglycinamidine synthase activity
BK049_RS04790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK049_RS04795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BK049_RS04800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK049_RS04805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BK049_RS04810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BK049_RS04820	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BK049_RS04825	COG3064	Membrane
BK049_RS04830	COG5583	Uncharacterized small protein (DUF2292)
BK049_RS04835	COG2252	PERMEase
BK049_RS04840	COG0583	DNA-binding transcription factor activity
BK049_RS04845	COG2814	Major facilitator Superfamily
BK049_RS04855	COG1595	DNA-templated transcription, initiation
BK049_RS04900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK049_RS04905	COG1917	Cupin 2, conserved barrel domain protein
BK049_RS04905	COG2207	Transcriptional regulator
BK049_RS04910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BK049_RS04915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK049_RS04915	COG0519	Catalyzes the synthesis of GMP from XMP
BK049_RS04920	COG1305	Transglutaminase-like
BK049_RS04925	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BK049_RS04930	COG0714	Associated with various cellular activities
BK049_RS04935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BK049_RS04940	COG1113	amino acid transport
BK049_RS04945	COG2132	Multicopper oxidase
BK049_RS04955	COG0823	Involved in the tonB-independent uptake of proteins
BK049_RS04960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BK049_RS04985	COG0328	RNA-DNA hybrid ribonuclease activity
BK049_RS04995	COG1876	peptidase activity
BK049_RS05055	COG3953	SLT domain
BK049_RS05055	COG5412	phage tail tape measure protein
BK049_RS05120	COG5484	DNA packaging
BK049_RS05140	COG3677	Transposase
BK049_RS05195	COG1484	DNA-dependent DNA replication
BK049_RS05205	COG3723	Recombinational DNA repair protein, rece pathway
BK049_RS05210	COG5377	YqaJ viral recombinase family
BK049_RS05250	COG1396	sequence-specific DNA binding
BK049_RS05260	COG2856	Zn peptidase
BK049_RS05265	COG4974	Belongs to the 'phage' integrase family
BK049_RS05270	COG0459	protein refolding
BK049_RS05275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BK049_RS05280	COG1266	CAAX protease self-immunity
BK049_RS05295	COG0805	protein transport
BK049_RS05300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BK049_RS05305	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BK049_RS05310	COG0315	cyclic pyranopterin monophosphate synthase activity
BK049_RS05315	COG0488	(ABC) transporter
BK049_RS05320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BK049_RS05325	COG0456	acetyltransferase
BK049_RS05330	COG1214	PFAM Peptidase M22, glycoprotease
BK049_RS05335	COG0802	atpase or kinase
BK049_RS05340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BK049_RS05380	COG1301	dicarboxylic acid transport
BK049_RS05390	COG0697	spore germination
BK049_RS05395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BK049_RS05405	COG4122	O-methyltransferase activity
BK049_RS05415	COG0456	acetyltransferase
BK049_RS05425	COG1396	sequence-specific DNA binding
BK049_RS05440	COG0778	Nitroreductase
BK049_RS05445	COG1846	Transcriptional regulator
BK049_RS05450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK049_RS05480	COG2814	Major facilitator Superfamily
BK049_RS05500	COG0252	asparaginase activity
BK049_RS05505	COG2801	Transposase and inactivated derivatives
BK049_RS05515	COG0477	Major facilitator Superfamily
BK049_RS05525	COG1064	alcohol dehydrogenase
BK049_RS05525	COG1064	alcohol dehydrogenase
BK049_RS05530	COG1329	Transcriptional regulator
BK049_RS05535	COG1278	Cold shock
BK049_RS05580	COG3284	Transcriptional regulator
BK049_RS05585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK049_RS05590	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK049_RS05595	COG0022	dehydrogenase e1 component
BK049_RS05600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BK049_RS05605	COG3091	SprT-like family
BK049_RS05610	COG2183	response to ionizing radiation
BK049_RS05615	COG2208	phosphoserine phosphatase activity
BK049_RS05620	COG1191	sigma factor activity
BK049_RS05625	COG2172	sigma factor antagonist activity
BK049_RS05630	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS05635	COG2208	phosphoserine phosphatase activity
BK049_RS05640	COG2172	sigma factor antagonist activity
BK049_RS05645	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS05650	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS05655	COG2337	Toxic component of a toxin-antitoxin (TA) module
BK049_RS05660	COG0864	Transcriptional regulator
BK049_RS05665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK049_RS05670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BK049_RS05675	COG0736	holo-[acyl-carrier-protein] synthase activity
BK049_RS05680	COG0705	Rhomboid family
BK049_RS05685	COG3428	Bacterial PH domain
BK049_RS05690	COG3402	PFAM membrane-flanked domain
BK049_RS05695	COG0513	Belongs to the DEAD box helicase family
BK049_RS05710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BK049_RS05715	COG1181	Belongs to the D-alanine--D-alanine ligase family
BK049_RS05720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS05735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BK049_RS05740	COG1131	(ABC) transporter
BK049_RS05745	COG1301	dicarboxylic acid transport
BK049_RS05750	COG0628	permease
BK049_RS05755	COG1301	dicarboxylic acid transport
BK049_RS05760	COG4565	transcriptional regulatory protein
BK049_RS05765	COG3290	protein histidine kinase activity
BK049_RS05770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BK049_RS05775	COG2217	Heavy metal translocating P-type atpase
BK049_RS05780	COG2261	transglycosylase associated protein
BK049_RS05785	COG1914	H( )-stimulated, divalent metal cation uptake system
BK049_RS05820	COG5444	nuclease activity
BK049_RS05825	COG0028	Belongs to the TPP enzyme family
BK049_RS05830	COG0531	amino acid
BK049_RS05840	COG1215	transferase activity, transferring glycosyl groups
BK049_RS05845	COG5298	Protein conserved in bacteria
BK049_RS05850	COG3706	GGDEF domain
BK049_RS05855	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BK049_RS05860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK049_RS05860	COG0551	DNA topoisomerase type I activity
BK049_RS05865	COG2814	Major facilitator Superfamily
BK049_RS05885	COG3871	stress protein (general stress protein 26)
BK049_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS05895	COG2226	methyltransferase
BK049_RS05900	COG3711	transcriptional antiterminator
BK049_RS05910	COG2755	lipolytic protein G-D-S-L family
BK049_RS05915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BK049_RS05920	COG1414	Transcriptional regulator
BK049_RS05925	COG1984	allophanate hydrolase subunit 2
BK049_RS05930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BK049_RS05935	COG4336	lyase activity
BK049_RS05940	COG1914	H( )-stimulated, divalent metal cation uptake system
BK049_RS05945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BK049_RS05950	COG0561	phosphatase activity
BK049_RS05960	COG0346	lactoylglutathione lyase activity
BK049_RS06000	COG0246	Mannitol dehydrogenase
BK049_RS06005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS06010	COG2213	PTS system mannitol-specific
BK049_RS06015	COG2372	response to copper ion
BK049_RS06015	COG1276	copper resistance
BK049_RS06020	COG4549	nuclear export factor GLE1
BK049_RS06025	COG2249	NAD(P)H dehydrogenase (quinone) activity
BK049_RS06030	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS06035	COG0531	amino acid
BK049_RS06040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BK049_RS06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK049_RS06050	COG0583	DNA-binding transcription factor activity
BK049_RS06060	COG0640	Transcriptional regulator
BK049_RS06065	COG1309	transcriptional regulator
BK049_RS06070	COG2814	Major facilitator Superfamily
BK049_RS06075	COG0527	aspartate kinase activity
BK049_RS06080	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS06085	COG5002	protein histidine kinase activity
BK049_RS06085	COG3850	Histidine kinase
BK049_RS06090	COG0745	RESPONSE REGULATOR receiver
BK049_RS06100	COG2801	Transposase and inactivated derivatives
BK049_RS06110	COG2079	MmgE PrpD family protein
BK049_RS06115	COG1473	amidohydrolase
BK049_RS06120	COG1126	abc transporter atp-binding protein
BK049_RS06125	COG0765	amino acid transport
BK049_RS06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS06135	COG0456	acetyltransferase
BK049_RS06140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS06145	COG5434	Belongs to the glycosyl hydrolase 28 family
BK049_RS06150	COG3104	oligopeptide transport
BK049_RS06170	COG1121	(ABC) transporter
BK049_RS06180	COG0833	amino acid
BK049_RS06190	COG2814	Major facilitator Superfamily
BK049_RS06195	COG0412	Dienelactone hydrolase
BK049_RS06205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS06210	COG0765	amino acid transport
BK049_RS06215	COG1126	abc transporter atp-binding protein
BK049_RS06220	COG2002	toxin-antitoxin pair type II binding
BK049_RS06225	COG3764	Sortase (surface protein transpeptidase)
BK049_RS06235	COG2364	Membrane
BK049_RS06260	COG4555	ABC transporter
BK049_RS06275	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BK049_RS06290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK049_RS06295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK049_RS06300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK049_RS06310	COG1176	ABC-type spermidine putrescine transport system, permease component I
BK049_RS06315	COG3842	ATPase activity
BK049_RS06320	COG2182	Extracellular solute-binding protein
BK049_RS06335	COG3209	COG3209 Rhs family protein
BK049_RS06340	COG0840	transmembrane signaling receptor activity
BK049_RS06340	COG3290	protein histidine kinase activity
BK049_RS06350	COG2746	aminoglycoside 3-N-acetyltransferase activity
BK049_RS06355	COG1522	sequence-specific DNA binding
BK049_RS06360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BK049_RS06370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS06375	COG0765	amino acid transport
BK049_RS06380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BK049_RS06385	COG2508	Transcriptional regulator
BK049_RS06390	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS06395	COG0506	proline dehydrogenase activity
BK049_RS06400	COG3541	Predicted nucleotidyltransferase
BK049_RS06410	COG3458	cephalosporin-C deacetylase activity
BK049_RS06415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK049_RS06420	COG0583	DNA-binding transcription factor activity
BK049_RS06425	COG2226	methyltransferase
BK049_RS06430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BK049_RS06435	COG1414	Transcriptional regulator
BK049_RS06445	COG2271	Major facilitator Superfamily
BK049_RS06450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BK049_RS06460	COG0028	Belongs to the TPP enzyme family
BK049_RS06465	COG0710	3-dehydroquinate dehydratase activity
BK049_RS06470	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS06485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BK049_RS06490	COG3665	Urea carboxylase-associated protein
BK049_RS06495	COG1113	amino acid transport
BK049_RS06500	COG3403	YqcI/YcgG family
BK049_RS06510	COG1280	lysine exporter protein (LysE YggA)
BK049_RS06515	COG0738	Major facilitator superfamily
BK049_RS06525	COG0561	phosphatase activity
BK049_RS06530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK049_RS06535	COG1609	Transcriptional regulator
BK049_RS06540	COG1620	l-lactate permease
BK049_RS06545	COG0039	L-malate dehydrogenase activity
BK049_RS06550	COG1473	amidohydrolase
BK049_RS06560	COG2113	Glycine betaine
BK049_RS06565	COG4176	ABC-type proline glycine betaine transport system permease component
BK049_RS06570	COG4175	Glycine betaine
BK049_RS06570	COG0517	IMP dehydrogenase activity
BK049_RS06575	COG3853	Toxic anion resistance protein (TelA)
BK049_RS06605	COG0861	Integral membrane protein TerC family
BK049_RS06610	COG2310	stress, protein
BK049_RS06615	COG2310	stress, protein
BK049_RS06620	COG2310	stress, protein
BK049_RS06625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS06640	COG3773	Cell wall hydrolase
BK049_RS06655	COG2801	Transposase and inactivated derivatives
BK049_RS06675	COG2801	Transposase and inactivated derivatives
BK049_RS06690	COG1668	transmembrane transport
BK049_RS06695	COG4555	ABC transporter
BK049_RS06700	COG3279	Response regulator of the LytR AlgR family
BK049_RS06705	COG3290	protein histidine kinase activity
BK049_RS06710	COG2801	Transposase and inactivated derivatives
BK049_RS06720	COG0667	Aldo Keto reductase
BK049_RS06730	COG1405	negative regulation of cell septum assembly
BK049_RS06730	COG3012	SEC-C Motif Domain Protein
BK049_RS06735	COG0784	Response regulator, receiver
BK049_RS06740	COG4191	Histidine kinase
BK049_RS06745	COG2066	Belongs to the glutaminase family
BK049_RS06750	COG1115	amino acid carrier protein
BK049_RS06755	COG0596	Alpha beta hydrolase
BK049_RS06765	COG0531	amino acid
BK049_RS06770	COG0318	PFAM AMP-dependent synthetase and ligase
BK049_RS06775	COG1846	Transcriptional regulator
BK049_RS06780	COG1917	Cupin 2, conserved barrel domain protein
BK049_RS06785	COG1309	transcriptional regulator
BK049_RS06795	COG1404	Belongs to the peptidase S8 family
BK049_RS06810	COG0456	acetyltransferase
BK049_RS06815	COG2814	Major facilitator Superfamily
BK049_RS06835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK049_RS06840	COG2040	homocysteine
BK049_RS06845	COG0833	amino acid
BK049_RS06855	COG1404	Belongs to the peptidase S8 family
BK049_RS06860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS06860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS06865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK049_RS06870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK049_RS06875	COG0383	alpha-mannosidase activity
BK049_RS06880	COG1940	carbohydrate kinase activity
BK049_RS06885	COG3711	transcriptional antiterminator
BK049_RS06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS06905	COG2801	Transposase and inactivated derivatives
BK049_RS06915	COG2723	6-phospho-beta-galactosidase activity
BK049_RS06920	COG2190	(PTS) system
BK049_RS06920	COG1263	PTS System
BK049_RS06920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS06925	COG3711	transcriptional antiterminator
BK049_RS06935	COG0531	amino acid
BK049_RS06940	COG1054	Belongs to the UPF0176 family
BK049_RS06945	COG0656	L-ascorbic acid biosynthetic process
BK049_RS06965	COG1846	Transcriptional regulator
BK049_RS06980	COG2814	Major facilitator Superfamily
BK049_RS06985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK049_RS06990	COG0730	response to heat
BK049_RS06995	COG0425	Belongs to the sulfur carrier protein TusA family
BK049_RS07000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK049_RS07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK049_RS07005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK049_RS07005	COG0425	Belongs to the sulfur carrier protein TusA family
BK049_RS07010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK049_RS07015	COG2210	Belongs to the sulfur carrier protein TusA family
BK049_RS07020	COG1937	Protein conserved in bacteria
BK049_RS07035	COG0640	Transcriptional regulator
BK049_RS07045	COG1331	Highly conserved protein containing a thioredoxin domain
BK049_RS07055	COG2271	Major facilitator Superfamily
BK049_RS07060	COG0584	glycerophosphoryl diester phosphodiesterase
BK049_RS07065	COG1113	amino acid transport
BK049_RS07070	COG2311	Membrane
BK049_RS07080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS07085	COG1413	lyase activity
BK049_RS07095	COG1131	(ABC) transporter
BK049_RS07120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BK049_RS07125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK049_RS07130	COG4856	YbbR-like protein
BK049_RS07135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BK049_RS07140	COG5662	AntiSigma factor
BK049_RS07145	COG1595	DNA-templated transcription, initiation
BK049_RS07180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BK049_RS07185	COG1737	Transcriptional regulator
BK049_RS07190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS07190	COG1263	PTS System
BK049_RS07195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BK049_RS07200	COG1472	Belongs to the glycosyl hydrolase 3 family
BK049_RS07205	COG3876	Protein conserved in bacteria
BK049_RS07210	COG0385	Bile acid
BK049_RS07215	COG2271	Major facilitator Superfamily
BK049_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS07225	COG1063	alcohol dehydrogenase
BK049_RS07230	COG4948	Mandelate Racemase Muconate Lactonizing
BK049_RS07265	COG0726	polysaccharide deacetylase
BK049_RS07270	COG2194	sulfuric ester hydrolase activity
BK049_RS07280	COG0489	protein tyrosine kinase activity
BK049_RS07285	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK049_RS07325	COG2801	Transposase and inactivated derivatives
BK049_RS07330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BK049_RS07335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BK049_RS07340	COG0101	tRNA pseudouridine synthase activity
BK049_RS07345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BK049_RS07350	COG1122	ATPase activity
BK049_RS07355	COG1122	ATPase activity
BK049_RS07360	COG0203	ribosomal protein L17
BK049_RS07365	COG0202	RNA polymerase activity
BK049_RS07370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK049_RS07375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK049_RS07380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BK049_RS07385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BK049_RS07390	COG0024	Methionine aminopeptidase
BK049_RS07395	COG0563	adenylate kinase activity
BK049_RS07400	COG0201	protein transport
BK049_RS07405	COG0200	Binds to the 23S rRNA
BK049_RS07410	COG1841	ribosomal large subunit assembly
BK049_RS07415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK049_RS07420	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BK049_RS07425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK049_RS07430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK049_RS07435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK049_RS07440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK049_RS07445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK049_RS07450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK049_RS07455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BK049_RS07460	COG0255	Belongs to the universal ribosomal protein uL29 family
BK049_RS07465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK049_RS07470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BK049_RS07475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BK049_RS07480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK049_RS07485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK049_RS07490	COG0089	rRNA binding
BK049_RS07495	COG0088	Forms part of the polypeptide exit tunnel
BK049_RS07500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK049_RS07510	COG0596	Alpha beta hydrolase
BK049_RS07515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK049_RS07520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK049_RS07525	COG0049	tRNA binding
BK049_RS07530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BK049_RS07535	COG1358	cellular component organization or biogenesis
BK049_RS07540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK049_RS07545	COG0085	RNA polymerase activity
BK049_RS07550	COG2813	Specifically methylates the guanine in position
BK049_RS07555	COG0222	ribosome binding
BK049_RS07560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BK049_RS07565	COG0081	regulation of translation
BK049_RS07575	COG0250	Participates in transcription elongation, termination and antitermination
BK049_RS07580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BK049_RS07585	COG1595	DNA-templated transcription, initiation
BK049_RS07590	COG3688	RNA-binding protein containing a PIN domain
BK049_RS07595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK049_RS07600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BK049_RS07605	COG0215	cysteine-tRNA ligase activity
BK049_RS07610	COG1045	serine acetyltransferase
BK049_RS07615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK049_RS07620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BK049_RS07625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BK049_RS07630	COG4956	integral membrane protein (PIN domain superfamily)
BK049_RS07635	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BK049_RS07640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BK049_RS07645	COG0542	response to heat
BK049_RS07650	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BK049_RS07655	COG3880	PFAM UvrB UvrC protein
BK049_RS07660	COG4463	regulation of RNA biosynthetic process
BK049_RS07740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BK049_RS07745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BK049_RS07750	COG1396	sequence-specific DNA binding
BK049_RS07755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BK049_RS07760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BK049_RS07765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BK049_RS07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK049_RS07775	COG0512	Glutamine amidotransferase of anthranilate synthase
BK049_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BK049_RS07785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK049_RS07790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BK049_RS07795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BK049_RS07800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BK049_RS07805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK049_RS07810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BK049_RS07815	COG0037	tRNA processing
BK049_RS07820	COG0515	serine threonine protein kinase
BK049_RS07825	COG2304	oxidoreductase activity
BK049_RS07830	COG2208	phosphoserine phosphatase activity
BK049_RS07845	COG1098	S1 RNA binding domain
BK049_RS07850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BK049_RS07865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BK049_RS07870	COG3956	TIGRFAM MazG family protein
BK049_RS07875	COG2244	polysaccharide biosynthetic process
BK049_RS07880	COG2002	toxin-antitoxin pair type II binding
BK049_RS07885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BK049_RS07895	COG0193	aminoacyl-tRNA hydrolase activity
BK049_RS07900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BK049_RS07905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BK049_RS07910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK049_RS07915	COG2088	sporulation resulting in formation of a cellular spore
BK049_RS07920	COG0251	oxidation-reduction process
BK049_RS07925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK049_RS07930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BK049_RS07940	COG4466	Protein conserved in bacteria
BK049_RS07950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK049_RS07955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BK049_RS07960	COG3584	3D domain protein
BK049_RS07960	COG3583	domain protein
BK049_RS07965	COG0084	hydrolase, TatD family'
BK049_RS07970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK049_RS07970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK049_RS07975	COG2002	toxin-antitoxin pair type II binding
BK049_RS07980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BK049_RS07985	COG2827	Endonuclease containing a URI domain
BK049_RS07990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BK049_RS07995	COG4467	Involved in initiation control of chromosome replication
BK049_RS08000	COG1774	PSP1 C-terminal conserved region
BK049_RS08005	COG0470	DNA polymerase III
BK049_RS08010	COG1728	Protein conserved in bacteria
BK049_RS08015	COG3870	Protein conserved in bacteria
BK049_RS08020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK049_RS08025	COG1982	Orn Lys Arg decarboxylase major
BK049_RS08030	COG3853	Toxic anion resistance protein (TelA)
BK049_RS08035	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BK049_RS08080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BK049_RS08085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BK049_RS08090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BK049_RS08100	COG0590	tRNA wobble adenosine to inosine editing
BK049_RS08105	COG1335	isochorismatase
BK049_RS08110	COG3858	chitin binding
BK049_RS08110	COG1388	LysM domain
BK049_RS08115	COG1428	Deoxynucleoside kinase
BK049_RS08120	COG1428	Deoxynucleoside kinase
BK049_RS08130	COG2801	Transposase and inactivated derivatives
BK049_RS08145	COG1847	R3H domain protein
BK049_RS08150	COG2208	phosphoserine phosphatase activity
BK049_RS08175	COG0300	oxidoreductase activity
BK049_RS08190	COG0840	transmembrane signaling receptor activity
BK049_RS08195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK049_RS08200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BK049_RS08205	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BK049_RS08210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK049_RS08225	COG1686	Belongs to the peptidase S11 family
BK049_RS08230	COG0516	GMP reductase activity
BK049_RS08230	COG0517	IMP dehydrogenase activity
BK049_RS08265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK049_RS08270	COG0187	DNA topoisomerase II activity
BK049_RS08280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BK049_RS08285	COG2501	S4 domain
BK049_RS08290	COG0592	DNA-directed DNA polymerase activity
BK049_RS08295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BK049_RS08300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BK049_RS08305	COG0594	ribonuclease P activity
BK049_RS08310	COG0706	membrane insertase activity
BK049_RS08315	COG1847	R3H domain protein
BK049_RS08320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BK049_RS08325	COG0445	tRNA wobble uridine modification
BK049_RS08330	COG0357	Ribosomal RNA small subunit methyltransferase G
BK049_RS08335	COG1475	DNA binding
BK049_RS08345	COG1192	Involved in chromosome partitioning
BK049_RS08350	COG1475	DNA binding
BK049_RS08360	COG3949	Membrane
BK049_RS08375	COG4481	Protein conserved in bacteria
BK049_RS08380	COG0012	GTP binding
BK049_RS08385	COG0360	Binds together with S18 to 16S ribosomal RNA
BK049_RS08390	COG0629	single-stranded DNA binding
BK049_RS08395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BK049_RS08400	COG0346	lactoylglutathione lyase activity
BK049_RS08405	COG0400	carboxylic ester hydrolase activity
BK049_RS08410	COG0655	NAD(P)H dehydrogenase (quinone) activity
BK049_RS08415	COG0753	catalase activity
BK049_RS08425	COG1595	DNA-templated transcription, initiation
BK049_RS08435	COG1227	inorganic diphosphatase activity
BK049_RS08440	COG4241	membrane
BK049_RS08445	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BK049_RS08450	COG0359	binds to the 23S rRNA
BK049_RS08455	COG2807	transmembrane transport
BK049_RS08460	COG3093	addiction module antidote protein HigA
BK049_RS08465	COG2819	hydrolase of the alpha beta superfamily
BK049_RS08470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS08475	COG2207	Transcriptional regulator
BK049_RS08475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS08480	COG2819	hydrolase of the alpha beta superfamily
BK049_RS08495	COG0305	Participates in initiation and elongation during chromosome replication
BK049_RS08500	COG0346	lactoylglutathione lyase activity
BK049_RS08505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BK049_RS08510	COG2311	Membrane
BK049_RS08545	COG0745	RESPONSE REGULATOR receiver
BK049_RS08550	COG5002	protein histidine kinase activity
BK049_RS08555	COG4863	YycH protein
BK049_RS08560	COG4853	Protein conserved in bacteria
BK049_RS08565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BK049_RS08570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK049_RS08575	COG0456	acetyltransferase
BK049_RS08595	COG4720	Psort location CytoplasmicMembrane, score
BK049_RS08605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BK049_RS08615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BK049_RS08685	COG0384	phenazine biosynthesis protein PhzF
BK049_RS08730	COG2814	Major facilitator Superfamily
BK049_RS08735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK049_RS08740	COG2814	Major facilitator Superfamily
BK049_RS08745	COG1609	Transcriptional regulator
BK049_RS08750	COG1113	amino acid transport
BK049_RS08765	COG0494	nUDIX hydrolase
BK049_RS08790	COG0457	Tetratricopeptide repeat
BK049_RS08800	COG1136	(ABC) transporter
BK049_RS08810	COG2814	Major facilitator Superfamily
BK049_RS08815	COG1309	transcriptional regulator
BK049_RS08820	COG1929	Belongs to the glycerate kinase type-1 family
BK049_RS08825	COG2824	Alkylphosphonate utilization operon protein PhnA
BK049_RS08835	COG1131	(ABC) transporter
BK049_RS08840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BK049_RS08850	COG2851	Citrate transporter
BK049_RS08855	COG1874	Beta-galactosidase
BK049_RS08865	COG3833	ABC-type maltose transport systems, permease component
BK049_RS08875	COG2182	Extracellular solute-binding protein
BK049_RS08880	COG1609	Transcriptional regulator
BK049_RS08885	COG0583	DNA-binding transcription factor activity
BK049_RS08920	COG1737	Transcriptional regulator
BK049_RS08925	COG1070	Carbohydrate kinase
BK049_RS08935	COG4335	DNA alkylation repair
BK049_RS08940	COG1113	amino acid transport
BK049_RS08950	COG0673	inositol 2-dehydrogenase activity
BK049_RS08955	COG0789	Transcriptional regulator
BK049_RS08960	COG0561	phosphatase activity
BK049_RS08970	COG2226	methyltransferase
BK049_RS08985	COG1404	Belongs to the peptidase S8 family
BK049_RS09005	COG2390	Transcriptional regulator
BK049_RS09010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK049_RS09015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BK049_RS09020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BK049_RS09035	COG1846	Transcriptional regulator
BK049_RS09040	COG0778	Nitroreductase
BK049_RS09045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BK049_RS09075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BK049_RS09080	COG4721	ABC-type cobalt transport system, permease component
BK049_RS09085	COG1122	ATPase activity
BK049_RS09090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BK049_RS09100	COG3878	Protein conserved in bacteria
BK049_RS09105	COG3711	transcriptional antiterminator
BK049_RS09110	COG1263	PTS System
BK049_RS09110	COG2190	(PTS) system
BK049_RS09110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS09115	COG2723	6-phospho-beta-galactosidase activity
BK049_RS09135	COG1136	(ABC) transporter
BK049_RS09145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BK049_RS09150	COG2610	gluconate transmembrane transporter activity
BK049_RS09160	COG2084	Dehydrogenase
BK049_RS09165	COG1737	Transcriptional regulator
BK049_RS09175	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK049_RS09180	COG4842	Belongs to the WXG100 family
BK049_RS09205	COG1396	sequence-specific DNA binding
BK049_RS09210	COG0252	asparaginase activity
BK049_RS09215	COG1027	Aspartate ammonia-lyase
BK049_RS09220	COG1757	Na H antiporter
BK049_RS09245	COG3711	transcriptional antiterminator
BK049_RS09245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS09250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS09255	COG1312	Catalyzes the dehydration of D-mannonate
BK049_RS09260	COG2723	6-phospho-beta-galactosidase activity
BK049_RS09265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS09270	COG1447	Phosphotransferase system cellobiose-specific component IIA
BK049_RS09275	COG0726	polysaccharide deacetylase
BK049_RS09285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK049_RS09285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK049_RS09290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK049_RS09290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK049_RS09295	COG2514	catechol 2,3-dioxygenase activity
BK049_RS09300	COG1733	regulation of RNA biosynthetic process
BK049_RS09305	COG5386	Cell surface protein
BK049_RS09310	COG5386	Cell surface protein
BK049_RS09335	COG4509	Sortase family
BK049_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS09355	COG1271	oxidase subunit
BK049_RS09360	COG1294	oxidase, subunit
BK049_RS09365	COG4988	ABC transporter
BK049_RS09370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BK049_RS09380	COG1595	DNA-templated transcription, initiation
BK049_RS09395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK049_RS09400	COG3711	transcriptional antiterminator
BK049_RS09400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS09405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS09410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS09415	COG1447	Phosphotransferase system cellobiose-specific component IIA
BK049_RS09420	COG1486	melibiose metabolic process
BK049_RS09430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK049_RS09435	COG3420	alginic acid biosynthetic process
BK049_RS09445	COG0745	RESPONSE REGULATOR receiver
BK049_RS09460	COG1129	ABC transporter
BK049_RS09465	COG1172	Belongs to the binding-protein-dependent transport system permease family
BK049_RS09470	COG2357	RelA SpoT domain protein
BK049_RS09475	COG0457	Tetratricopeptide repeat
BK049_RS09480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS09485	COG0765	amino acid transport
BK049_RS09495	COG0346	lactoylglutathione lyase activity
BK049_RS09500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BK049_RS09505	COG1346	cytolysis
BK049_RS09510	COG1380	Effector of murein hydrolase LrgA
BK049_RS09515	COG0583	DNA-binding transcription factor activity
BK049_RS09520	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BK049_RS09525	COG0352	thiamine-phosphate diphosphorylase activity
BK049_RS09540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK049_RS09545	COG3162	membrane
BK049_RS09565	COG2246	polysaccharide biosynthetic process
BK049_RS09580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BK049_RS09585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK049_RS09590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BK049_RS09600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BK049_RS09605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BK049_RS09610	COG1845	cytochrome c oxidase, subunit III
BK049_RS09615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BK049_RS09625	COG0772	Belongs to the SEDS family
BK049_RS09630	COG0778	Nitroreductase
BK049_RS09635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS09645	COG1404	Belongs to the peptidase S8 family
BK049_RS09655	COG3711	transcriptional antiterminator
BK049_RS09660	COG1263	PTS System
BK049_RS09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK049_RS09665	COG1621	beta-fructofuranosidase activity
BK049_RS09680	COG0351	phosphomethylpyrimidine kinase
BK049_RS09690	COG1216	Glycosyl transferase, family 2
BK049_RS09695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BK049_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS09710	COG2233	PERMEase
BK049_RS09715	COG2363	Small membrane protein
BK049_RS09735	COG0463	Glycosyl transferase, family 2
BK049_RS09740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK049_RS09745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK049_RS09750	COG0456	acetyltransferase
BK049_RS09755	COG2089	acid synthase
BK049_RS09760	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BK049_RS09765	COG3980	spore coat polysaccharide biosynthesis protein
BK049_RS09770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BK049_RS09775	COG1088	dTDP-glucose 4,6-dehydratase activity
BK049_RS09780	COG1091	dTDP-4-dehydrorhamnose reductase activity
BK049_RS09785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BK049_RS09790	COG2814	Major facilitator Superfamily
BK049_RS09795	COG1522	sequence-specific DNA binding
BK049_RS09800	COG2814	Major facilitator Superfamily
BK049_RS09810	COG0280	phosphate acetyltransferase
BK049_RS09825	COG5444	nuclease activity
BK049_RS09880	COG4844	belongs to the
BK049_RS09885	COG1078	dGTPase activity
BK049_RS09890	COG3465	dGTPase activity
BK049_RS09895	COG1126	abc transporter atp-binding protein
BK049_RS09900	COG0765	amino acid transport
BK049_RS09910	COG0765	amino acid transport
BK049_RS09915	COG0454	-acetyltransferase
BK049_RS09920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BK049_RS09925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS09930	COG0431	NADPH-dependent FMN reductase
BK049_RS09935	COG0583	DNA-binding transcription factor activity
BK049_RS09940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS09970	COG1131	(ABC) transporter
BK049_RS09975	COG1942	4-Oxalocrotonate Tautomerase
BK049_RS09980	COG1994	Peptidase M50
BK049_RS09990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK049_RS09995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BK049_RS10000	COG0010	Belongs to the arginase family
BK049_RS10010	COG4506	Protein conserved in bacteria
BK049_RS10015	COG0018	arginyl-trna synthetase
BK049_RS10025	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK049_RS10030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK049_RS10035	COG1132	(ABC) transporter
BK049_RS10045	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK049_RS10055	COG4294	response to UV
BK049_RS10060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK049_RS10065	COG0247	lactate metabolic process
BK049_RS10065	COG2181	nitrate reductase activity
BK049_RS10070	COG0183	Belongs to the thiolase family
BK049_RS10075	COG1250	3-hydroxyacyl-CoA dehydrogenase
BK049_RS10080	COG1960	acyl-CoA dehydrogenase activity
BK049_RS10085	COG1960	acyl-CoA dehydrogenase activity
BK049_RS10095	COG3343	RNA polymerase activity
BK049_RS10100	COG0504	CTP synthase activity
BK049_RS10105	COG4821	SIS domain
BK049_RS10110	COG2204	response regulator
BK049_RS10115	COG0191	fructose-bisphosphate aldolase activity
BK049_RS10120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BK049_RS10125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BK049_RS10130	COG1494	fructose-1,6-bisphosphatase
BK049_RS10135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BK049_RS10140	COG0254	rRNA binding
BK049_RS10145	COG1435	thymidine kinase activity
BK049_RS10150	COG0281	malic enzyme
BK049_RS10155	COG0679	Auxin Efflux Carrier
BK049_RS10160	COG0789	Transcriptional regulator
BK049_RS10165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BK049_RS10170	COG2890	protein-(glutamine-N5) methyltransferase activity
BK049_RS10185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BK049_RS10190	COG0009	L-threonylcarbamoyladenylate synthase
BK049_RS10195	COG1971	Probably functions as a manganese efflux pump
BK049_RS10200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK049_RS10205	COG0698	ribose 5-phosphate isomerase
BK049_RS10210	COG4475	Protein of unknown function (DUF436)
BK049_RS10215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BK049_RS10220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK049_RS10230	COG0356	it plays a direct role in the translocation of protons across the membrane
BK049_RS10235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK049_RS10240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BK049_RS10245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK049_RS10250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BK049_RS10255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BK049_RS10260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BK049_RS10265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BK049_RS10275	COG4836	Membrane
BK049_RS10285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BK049_RS10290	COG2385	sporulation resulting in formation of a cellular spore
BK049_RS10295	COG2304	oxidoreductase activity
BK049_RS10300	COG2304	oxidoreductase activity
BK049_RS10305	COG0243	molybdopterin cofactor binding
BK049_RS10310	COG2223	nitrite transmembrane transporter activity
BK049_RS10315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BK049_RS10320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK049_RS10325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK049_RS10330	COG0523	cobalamin synthesis protein
BK049_RS10335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK049_RS10370	COG1247	-acetyltransferase
BK049_RS10375	COG0739	heme binding
BK049_RS10380	COG0347	Belongs to the P(II) protein family
BK049_RS10385	COG0004	ammonium transporteR
BK049_RS10390	COG1126	abc transporter atp-binding protein
BK049_RS10395	COG0765	amino acid transport
BK049_RS10400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS10405	COG0477	Major facilitator Superfamily
BK049_RS10410	COG0671	phosphoesterase, PA-phosphatase related
BK049_RS10415	COG2814	Major facilitator Superfamily
BK049_RS10420	COG1846	Transcriptional regulator
BK049_RS10425	COG1609	Transcriptional regulator
BK049_RS10430	COG1077	Cell shape determining protein MreB Mrl
BK049_RS10435	COG4786	Flagellar basal body rod
BK049_RS10440	COG4786	Flagellar basal body rod
BK049_RS10445	COG0457	Tetratricopeptide repeat
BK049_RS10450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BK049_RS10455	COG1970	mechanosensitive ion channel activity
BK049_RS10470	COG0561	phosphatase activity
BK049_RS10475	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS10475	COG2202	Pas domain
BK049_RS10480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK049_RS10485	COG4715	Zinc finger, swim domain protein
BK049_RS10490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BK049_RS10495	COG2059	Chromate
BK049_RS10500	COG2059	Chromate
BK049_RS10505	COG1522	sequence-specific DNA binding
BK049_RS10515	COG3527	Alpha-acetolactate decarboxylase
BK049_RS10520	COG0028	Belongs to the TPP enzyme family
BK049_RS10525	COG0583	DNA-binding transcription factor activity
BK049_RS10530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BK049_RS10535	COG1879	ABC-type sugar transport system periplasmic component
BK049_RS10540	COG1172	Belongs to the binding-protein-dependent transport system permease family
BK049_RS10545	COG1129	ABC transporter
BK049_RS10550	COG1869	D-ribose catabolic process
BK049_RS10555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK049_RS10560	COG1609	Transcriptional regulator
BK049_RS10575	COG0697	spore germination
BK049_RS10580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK049_RS10590	COG2843	Capsule synthesis protein
BK049_RS10595	COG0791	NLP P60 protein
BK049_RS10600	COG0561	phosphatase activity
BK049_RS10605	COG1316	TRANSCRIPTIONal
BK049_RS10610	COG2814	Major facilitator Superfamily
BK049_RS10615	COG1216	Glycosyl transferase, family 2
BK049_RS10625	COG0814	amino acid
BK049_RS10630	COG0697	spore germination
BK049_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS10640	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BK049_RS10645	COG1609	Transcriptional regulator
BK049_RS10650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK049_RS10655	COG0800	Aldolase
BK049_RS10660	COG0454	-acetyltransferase
BK049_RS10670	COG2972	Histidine kinase
BK049_RS10675	COG2197	response regulator
BK049_RS10680	COG1653	transport
BK049_RS10685	COG1175	transmembrane transport
BK049_RS10695	COG1482	cell wall glycoprotein biosynthetic process
BK049_RS10700	COG0463	Glycosyl transferase, family 2
BK049_RS10700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK049_RS10705	COG4193	domain, Protein
BK049_RS10710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK049_RS10715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BK049_RS10720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BK049_RS10730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK049_RS10735	COG1682	transport, permease protein
BK049_RS10740	COG1134	teichoic acid transport
BK049_RS10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK049_RS10750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BK049_RS10760	COG1316	TRANSCRIPTIONal
BK049_RS10770	COG2247	cell wall binding repeat
BK049_RS10770	COG2385	sporulation resulting in formation of a cellular spore
BK049_RS10775	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK049_RS10775	COG2247	cell wall binding repeat
BK049_RS10795	COG2244	polysaccharide biosynthetic process
BK049_RS10800	COG0438	transferase activity, transferring glycosyl groups
BK049_RS10800	COG0297	glycogen (starch) synthase activity
BK049_RS10805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BK049_RS10810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK049_RS10815	COG3307	-O-antigen
BK049_RS10820	COG3206	protein involved in exopolysaccharide biosynthesis
BK049_RS10825	COG1215	transferase activity, transferring glycosyl groups
BK049_RS10830	COG0438	transferase activity, transferring glycosyl groups
BK049_RS10835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK049_RS10845	COG1316	TRANSCRIPTIONal
BK049_RS10850	COG1739	Uncharacterized protein family UPF0029
BK049_RS10855	COG4585	Histidine kinase
BK049_RS10860	COG2197	response regulator
BK049_RS10865	COG1307	EDD domain protein, DegV family
BK049_RS10870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BK049_RS10880	COG1040	competence protein
BK049_RS10895	COG3418	PFAM FlgN family protein
BK049_RS10900	COG4786	Flagellar basal body rod
BK049_RS10900	COG1256	bacterial-type flagellum assembly
BK049_RS10905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BK049_RS10915	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BK049_RS10920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BK049_RS10925	COG1334	flagellar protein FlaG
BK049_RS10930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BK049_RS10935	COG1516	flagellar protein fliS
BK049_RS10950	COG0840	transmembrane signaling receptor activity
BK049_RS10955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BK049_RS10960	COG0653	protein targeting
BK049_RS10965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BK049_RS10980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK049_RS10985	COG2010	Cytochrome c
BK049_RS10990	COG2884	Cell division ATP-binding protein ftsE
BK049_RS10995	COG2177	Part of the ABC transporter FtsEX involved in
BK049_RS11000	COG0791	NLP P60 protein
BK049_RS11000	COG3883	PFAM NLP P60 protein
BK049_RS11005	COG0730	response to heat
BK049_RS11010	COG0793	Belongs to the peptidase S41A family
BK049_RS11010	COG3409	Peptidoglycan-binding domain 1 protein
BK049_RS11020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK049_RS11025	COG3866	Pectate lyase
BK049_RS11030	COG0778	Nitroreductase
BK049_RS11035	COG1113	amino acid transport
BK049_RS11040	COG0463	Glycosyl transferase, family 2
BK049_RS11045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BK049_RS11050	COG5002	protein histidine kinase activity
BK049_RS11055	COG0745	RESPONSE REGULATOR receiver
BK049_RS11065	COG2814	Major facilitator Superfamily
BK049_RS11070	COG1309	transcriptional regulator
BK049_RS11075	COG3848	Pyruvate phosphate dikinase
BK049_RS11075	COG0574	Belongs to the PEP-utilizing enzyme family
BK049_RS11080	COG4897	Protein conserved in bacteria
BK049_RS11095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BK049_RS11110	COG3595	metallopeptidase activity
BK049_RS11115	COG1983	PspC domain protein
BK049_RS11120	COG1950	PFAM Membrane protein of
BK049_RS11125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BK049_RS11130	COG2188	Transcriptional regulator
BK049_RS11135	COG0363	glucosamine-6-phosphate deaminase activity
BK049_RS11140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BK049_RS11145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BK049_RS11150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BK049_RS11155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BK049_RS11160	COG0546	phosphoglycolate phosphatase activity
BK049_RS11165	COG0110	maltose O-acetyltransferase activity
BK049_RS11170	COG1959	2 iron, 2 sulfur cluster binding
BK049_RS11175	COG2910	NAD(P)H-binding
BK049_RS11180	COG4990	cell redox homeostasis
BK049_RS11185	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BK049_RS11190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BK049_RS11195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BK049_RS11200	COG0131	Imidazoleglycerol-phosphate dehydratase
BK049_RS11205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BK049_RS11210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BK049_RS11215	COG0107	imidazoleglycerol-phosphate synthase activity
BK049_RS11220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BK049_RS11220	COG0140	phosphoribosyl-ATP diphosphatase activity
BK049_RS11225	COG0457	Tetratricopeptide repeat
BK049_RS11230	COG3883	PFAM NLP P60 protein
BK049_RS11230	COG0791	NLP P60 protein
BK049_RS11235	COG0492	ferredoxin-NADP+ reductase activity
BK049_RS11240	COG1051	belongs to the nudix hydrolase family
BK049_RS11245	COG1660	Displays ATPase and GTPase activities
BK049_RS11250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BK049_RS11255	COG1481	regulation of sporulation
BK049_RS11260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS11265	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BK049_RS11280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK049_RS11285	COG0659	secondary active sulfate transmembrane transporter activity
BK049_RS11290	COG0740	serine-type endopeptidase activity
BK049_RS11310	COG1819	glycosyl
BK049_RS11315	COG0747	negative chemotaxis
BK049_RS11320	COG0601	transmembrane transport
BK049_RS11335	COG1124	(ABC) transporter
BK049_RS11340	COG0726	polysaccharide deacetylase
BK049_RS11345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS11350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS11355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS11365	COG1396	sequence-specific DNA binding
BK049_RS11370	COG3944	biosynthesis protein
BK049_RS11375	COG0489	protein tyrosine kinase activity
BK049_RS11380	COG1086	Polysaccharide biosynthesis protein
BK049_RS11385	COG0438	transferase activity, transferring glycosyl groups
BK049_RS11390	COG1215	transferase activity, transferring glycosyl groups
BK049_RS11395	COG0438	transferase activity, transferring glycosyl groups
BK049_RS11405	COG1216	Glycosyl transferase, family 2
BK049_RS11410	COG5039	Polysaccharide pyruvyl transferase
BK049_RS11415	COG2244	polysaccharide biosynthetic process
BK049_RS11420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BK049_RS11425	COG0110	maltose O-acetyltransferase activity
BK049_RS11430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK049_RS11440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BK049_RS11445	COG2186	Transcriptional regulator
BK049_RS11450	COG3829	transcription factor binding
BK049_RS11455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BK049_RS11460	COG0833	amino acid
BK049_RS11465	COG2390	Transcriptional regulator
BK049_RS11470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BK049_RS11475	COG0126	phosphoglycerate kinase activity
BK049_RS11480	COG0149	triose-phosphate isomerase activity
BK049_RS11485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BK049_RS11490	COG0148	phosphopyruvate hydratase activity
BK049_RS11500	COG1131	(ABC) transporter
BK049_RS11520	COG0456	acetyltransferase
BK049_RS11525	COG2095	MarC family integral membrane protein
BK049_RS11530	COG1510	regulation of RNA biosynthetic process
BK049_RS11535	COG0517	IMP dehydrogenase activity
BK049_RS11535	COG1125	glycine betaine transport
BK049_RS11540	COG1174	glycine betaine transport
BK049_RS11545	COG1732	Glycine betaine
BK049_RS11550	COG1174	glycine betaine transport
BK049_RS11555	COG1733	regulation of RNA biosynthetic process
BK049_RS11560	COG1396	sequence-specific DNA binding
BK049_RS11565	COG1396	sequence-specific DNA binding
BK049_RS11570	COG1476	TRANSCRIPTIONal
BK049_RS11575	COG2002	toxin-antitoxin pair type II binding
BK049_RS11580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BK049_RS11585	COG1647	Serine aminopeptidase, S33
BK049_RS11590	COG0557	exoribonuclease II activity
BK049_RS11595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BK049_RS11680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BK049_RS11685	COG0582	viral genome integration into host DNA
BK049_RS11710	COG1802	Transcriptional regulator
BK049_RS11710	COG4626	Terminase
BK049_RS11790	COG1705	Flagellar rod assembly protein muramidase FlgJ
BK049_RS11790	COG1388	LysM domain
BK049_RS11815	COG4824	toxin secretion phage lysis holin
BK049_RS11820	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK049_RS11830	COG2801	Transposase and inactivated derivatives
BK049_RS11945	COG1937	Protein conserved in bacteria
BK049_RS11950	COG2608	mercury ion transmembrane transporter activity
BK049_RS11955	COG2217	Heavy metal translocating P-type atpase
BK049_RS11965	COG1027	Aspartate ammonia-lyase
BK049_RS11970	COG4191	Histidine kinase
BK049_RS11975	COG0784	Response regulator, receiver
BK049_RS11985	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK049_RS11990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK049_RS11995	COG1121	(ABC) transporter
BK049_RS12000	COG2217	Heavy metal translocating P-type atpase
BK049_RS12005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BK049_RS12010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BK049_RS12015	COG2860	membrane
BK049_RS12020	COG0025	NhaP-type Na H and K H
BK049_RS12025	COG1940	carbohydrate kinase activity
BK049_RS12030	COG0656	L-ascorbic acid biosynthetic process
BK049_RS12035	COG4149	molybdate abc transporter
BK049_RS12040	COG0725	ABC transporter, periplasmic molybdate-binding protein
BK049_RS12045	COG1368	sulfuric ester hydrolase activity
BK049_RS12050	COG1988	membrane-bound metal-dependent
BK049_RS12070	COG0531	amino acid
BK049_RS12075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS12080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS12085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS12090	COG1120	ATPase activity
BK049_RS12095	COG0745	RESPONSE REGULATOR receiver
BK049_RS12100	COG2205	protein histidine kinase activity
BK049_RS12105	COG1904	glucuronate isomerase
BK049_RS12110	COG1609	Transcriptional regulator
BK049_RS12115	COG0246	Mannitol dehydrogenase
BK049_RS12120	COG2721	sulfolactate sulfo-lyase activity
BK049_RS12130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS12135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS12140	COG1120	ATPase activity
BK049_RS12145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BK049_RS12150	COG1454	alcohol dehydrogenase
BK049_RS12165	COG2204	response regulator
BK049_RS12175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BK049_RS12185	COG2096	Adenosyltransferase
BK049_RS12190	COG4758	membrane
BK049_RS12195	COG1842	Phage shock protein A
BK049_RS12205	COG4758	membrane
BK049_RS12210	COG4585	Histidine kinase
BK049_RS12215	COG2197	response regulator
BK049_RS12230	COG0814	amino acid
BK049_RS12235	COG0697	spore germination
BK049_RS12240	COG0114	fumarate hydratase activity
BK049_RS12245	COG1309	transcriptional regulator
BK049_RS12250	COG2770	Histidine kinase
BK049_RS12250	COG2205	protein histidine kinase activity
BK049_RS12255	COG0745	RESPONSE REGULATOR receiver
BK049_RS12260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK049_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS12275	COG1120	ATPase activity
BK049_RS12285	COG5577	PFAM Coat F domain
BK049_RS12295	COG1250	3-hydroxyacyl-CoA dehydrogenase
BK049_RS12295	COG1024	Enoyl-CoA hydratase
BK049_RS12300	COG0183	Belongs to the thiolase family
BK049_RS12305	COG1960	acyl-CoA dehydrogenase activity
BK049_RS12310	COG1393	Belongs to the ArsC family
BK049_RS12315	COG0509	glycine decarboxylation via glycine cleavage system
BK049_RS12325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BK049_RS12330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS12340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK049_RS12345	COG2011	ABC-type metal ion transport system permease component
BK049_RS12350	COG1464	Belongs to the NlpA lipoprotein family
BK049_RS12355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BK049_RS12360	COG0396	ATPase activity
BK049_RS12365	COG0719	Fe-S assembly protein
BK049_RS12370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK049_RS12375	COG0822	iron-sulfur transferase activity
BK049_RS12380	COG0719	Fe-S assembly protein
BK049_RS12415	COG0457	Tetratricopeptide repeat
BK049_RS12420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS12425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS12430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK049_RS12440	COG2356	endonuclease I
BK049_RS12445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BK049_RS12450	COG2814	Major facilitator Superfamily
BK049_RS12455	COG2140	Oxalate decarboxylase
BK049_RS12460	COG2508	Transcriptional regulator
BK049_RS12465	COG1801	Protein of unknown function DUF72
BK049_RS12470	COG0737	Belongs to the 5'-nucleotidase family
BK049_RS12475	COG3377	Domain of unknown function (DUF1805)
BK049_RS12490	COG0739	heme binding
BK049_RS12500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BK049_RS12510	COG4470	Protein conserved in bacteria
BK049_RS12515	COG2445	Protein of unknown function DUF86
BK049_RS12520	COG0647	UMP catabolic process
BK049_RS12525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK049_RS12530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BK049_RS12535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK049_RS12540	COG0460	homoserine dehydrogenase
BK049_RS12545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BK049_RS12550	COG0083	homoserine kinase activity
BK049_RS12555	COG4946	Tricorn protease homolog
BK049_RS12555	COG1506	peptidase
BK049_RS12555	COG0823	Involved in the tonB-independent uptake of proteins
BK049_RS12560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BK049_RS12565	COG4837	Protein of unknown function (DUF1462)
BK049_RS12575	COG1252	NADH dehydrogenase
BK049_RS12580	COG4844	belongs to the
BK049_RS12585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BK049_RS12590	COG0316	Belongs to the HesB IscA family
BK049_RS12615	COG0492	ferredoxin-NADP+ reductase activity
BK049_RS12620	COG1252	NADH dehydrogenase
BK049_RS12630	COG3584	3D domain protein
BK049_RS12635	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BK049_RS12640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BK049_RS12645	COG2056	Na+-H+ antiporter family
BK049_RS12650	COG1268	BioY protein
BK049_RS12655	COG0686	Belongs to the AlaDH PNT family
BK049_RS12660	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BK049_RS12660	COG2508	Transcriptional regulator
BK049_RS12665	COG4842	Belongs to the WXG100 family
BK049_RS12670	COG5417	Belongs to the EsaB family
BK049_RS12675	COG4499	WXG100 protein secretion system (Wss), protein YukC
BK049_RS12680	COG1674	ftsk spoiiie
BK049_RS12680	COG0433	COG0433 Predicted ATPase
BK049_RS12685	COG1511	domain protein
BK049_RS12695	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS12700	COG1418	mRNA catabolic process
BK049_RS12715	COG0628	permease
BK049_RS12735	COG5506	Protein of unknown function (DUF1694)
BK049_RS12740	COG1335	isochorismatase
BK049_RS12745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BK049_RS12750	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BK049_RS12765	COG0142	geranyltranstransferase activity
BK049_RS12770	COG4585	Histidine kinase
BK049_RS12775	COG2197	response regulator
BK049_RS12780	COG2050	protein possibly involved in aromatic compounds catabolism
BK049_RS12785	COG1320	monovalent cation:proton antiporter activity
BK049_RS12790	COG2212	antiporter activity
BK049_RS12795	COG1863	multisubunit Na H antiporter MnhE subunit
BK049_RS12800	COG0651	ATP synthesis coupled electron transport
BK049_RS12805	COG1006	Multisubunit Na H antiporter MnhC subunit
BK049_RS12810	COG2111	Na H antiporter
BK049_RS12815	COG2111	Na H antiporter
BK049_RS12815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BK049_RS12825	COG3493	citrate carrier protein
BK049_RS12830	COG1079	Belongs to the binding-protein-dependent transport system permease family
BK049_RS12835	COG4603	Belongs to the binding-protein-dependent transport system permease family
BK049_RS12840	COG3845	ABC transporter
BK049_RS12845	COG1744	ABC transporter substrate-binding protein PnrA-like
BK049_RS12850	COG4565	transcriptional regulatory protein
BK049_RS12855	COG3290	protein histidine kinase activity
BK049_RS12865	COG3011	Protein conserved in bacteria
BK049_RS12870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK049_RS12875	COG2814	Major facilitator Superfamily
BK049_RS12880	COG5018	Exonuclease
BK049_RS12895	COG2205	protein histidine kinase activity
BK049_RS12900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BK049_RS12910	COG2267	carboxylic ester hydrolase activity
BK049_RS12915	COG1522	sequence-specific DNA binding
BK049_RS12920	COG0436	Aminotransferase
BK049_RS12925	COG1098	S1 RNA binding domain
BK049_RS12930	COG2155	Conserved Protein
BK049_RS12935	COG1979	alcohol dehydrogenase
BK049_RS12940	COG1979	alcohol dehydrogenase
BK049_RS12945	COG0166	Belongs to the GPI family
BK049_RS12960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BK049_RS12970	COG2738	Putative neutral zinc metallopeptidase
BK049_RS12975	COG1253	flavin adenine dinucleotide binding
BK049_RS12980	COG0432	Pfam Uncharacterised protein family UPF0047
BK049_RS12985	COG2070	2-Nitropropane dioxygenase
BK049_RS13000	COG0840	transmembrane signaling receptor activity
BK049_RS13005	COG0840	transmembrane signaling receptor activity
BK049_RS13010	COG0840	transmembrane signaling receptor activity
BK049_RS13015	COG0840	transmembrane signaling receptor activity
BK049_RS13020	COG0693	protein deglycase activity
BK049_RS13025	COG0673	inositol 2-dehydrogenase activity
BK049_RS13035	COG0628	permease
BK049_RS13040	COG1968	undecaprenyl-diphosphatase activity
BK049_RS13050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BK049_RS13060	COG1396	sequence-specific DNA binding
BK049_RS13070	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BK049_RS13080	COG1595	DNA-templated transcription, initiation
BK049_RS13085	COG5484	DNA packaging
BK049_RS13090	COG1783	phage Terminase large subunit
BK049_RS13095	COG5518	Phage portal protein
BK049_RS13100	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BK049_RS13105	COG4653	Phage capsid family
BK049_RS13150	COG3953	SLT domain
BK049_RS13150	COG5280	Phage tail tape measure protein TP901
BK049_RS13150	COG3953	SLT domain
BK049_RS13150	COG5280	Phage tail tape measure protein TP901
BK049_RS13155	COG1652	LysM domain
BK049_RS13160	COG4193	domain, Protein
BK049_RS13170	COG3628	GPW Gp25 family protein
BK049_RS13175	COG3299	homolog of phage Mu protein gp47
BK049_RS13180	COG3778	Protein conserved in bacteria
BK049_RS13230	COG3594	Acyltransferase
BK049_RS13245	COG1510	regulation of RNA biosynthetic process
BK049_RS13250	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS13255	COG1454	alcohol dehydrogenase
BK049_RS13260	COG2318	DinB family
BK049_RS13265	COG1585	Membrane protein implicated in regulation of membrane protease activity
BK049_RS13270	COG2268	Band 7 protein
BK049_RS13275	COG0772	Belongs to the SEDS family
BK049_RS13280	COG0772	Belongs to the SEDS family
BK049_RS13285	COG3339	Conserved Protein
BK049_RS13290	COG1247	-acetyltransferase
BK049_RS13295	COG3859	Proton-coupled thiamine transporter YuaJ
BK049_RS13425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BK049_RS13430	COG1575	Belongs to the MenA family. Type 1 subfamily
BK049_RS13435	COG1169	isochorismate synthase
BK049_RS13440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BK049_RS13445	COG0596	Alpha beta hydrolase
BK049_RS13450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BK049_RS13455	COG0318	PFAM AMP-dependent synthetase and ligase
BK049_RS13460	COG4948	Mandelate Racemase Muconate Lactonizing
BK049_RS13475	COG1294	oxidase, subunit
BK049_RS13480	COG1271	oxidase subunit
BK049_RS13485	COG0254	rRNA binding
BK049_RS13490	COG3443	Belongs to the bacterial solute-binding protein 9 family
BK049_RS13490	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK049_RS13495	COG0288	reversible hydration of carbon dioxide
BK049_RS13500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BK049_RS13505	COG1854	S-ribosylhomocysteine lyase activity
BK049_RS13520	COG0783	Belongs to the Dps family
BK049_RS13530	COG4824	toxin secretion phage lysis holin
BK049_RS13545	COG2310	stress, protein
BK049_RS13550	COG0494	nUDIX hydrolase
BK049_RS13555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BK049_RS13560	COG1116	anion transmembrane transporter activity
BK049_RS13565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BK049_RS13585	COG1233	COG1233 Phytoene dehydrogenase and related
BK049_RS13590	COG1506	peptidase
BK049_RS13600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BK049_RS13605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK049_RS13610	COG0367	asparagine synthase
BK049_RS13615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BK049_RS13620	COG2267	carboxylic ester hydrolase activity
BK049_RS13630	COG4326	sporulation control protein
BK049_RS13635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BK049_RS13640	COG1242	4 iron, 4 sulfur cluster binding
BK049_RS13655	COG1725	Transcriptional regulator
BK049_RS13660	COG1131	(ABC) transporter
BK049_RS13670	COG1136	(ABC) transporter
BK049_RS13675	COG0577	efflux transmembrane transporter activity
BK049_RS13680	COG2433	Pfam Transposase IS66
BK049_RS13685	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS13685	COG2202	Pas domain
BK049_RS13695	COG0495	leucyl-tRNA aminoacylation
BK049_RS13700	COG1073	alpha beta
BK049_RS13705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK049_RS13710	COG0395	ABC-type sugar transport system, permease component
BK049_RS13715	COG1653	transport
BK049_RS13720	COG1733	regulation of RNA biosynthetic process
BK049_RS13725	COG2207	Transcriptional regulator
BK049_RS13730	COG4209	transmembrane transport
BK049_RS13735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BK049_RS13740	COG1653	transport
BK049_RS13745	COG0673	inositol 2-dehydrogenase activity
BK049_RS13750	COG5578	integral membrane protein
BK049_RS13755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK049_RS13765	COG3196	Protein conserved in bacteria
BK049_RS13775	COG2081	HI0933 family
BK049_RS13780	COG2244	polysaccharide biosynthetic process
BK049_RS13785	COG1187	pseudouridine synthase activity
BK049_RS13790	COG1349	DNA-binding transcription factor activity
BK049_RS13795	COG2252	PERMEase
BK049_RS13800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK049_RS13810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK049_RS13815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BK049_RS13825	COG1597	lipid kinase activity
BK049_RS13830	COG0510	thiamine kinase activity
BK049_RS13840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BK049_RS13845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK049_RS13850	COG0281	malic enzyme
BK049_RS13855	COG5584	Small secreted protein
BK049_RS13860	COG1363	Peptidase, m42
BK049_RS13875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS13880	COG4848	Belongs to the UPF0354 family
BK049_RS13885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK049_RS13890	COG1674	ftsk spoiiie
BK049_RS13895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BK049_RS13900	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BK049_RS13905	COG4980	gas vesicle protein
BK049_RS13910	COG3118	belongs to the thioredoxin family
BK049_RS13915	COG1605	Chorismate mutase
BK049_RS13915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BK049_RS13920	COG1609	Transcriptional regulator
BK049_RS13925	COG0123	including yeast histone deacetylase and acetoin utilization protein
BK049_RS13930	COG0517	IMP dehydrogenase activity
BK049_RS13935	COG0454	-acetyltransferase
BK049_RS13940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK049_RS13945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK049_RS13955	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BK049_RS13960	COG1335	isochorismatase
BK049_RS13970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK049_RS13975	COG1956	GAF domain-containing protein
BK049_RS13980	COG1309	transcriptional regulator
BK049_RS13985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK049_RS13990	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BK049_RS13995	COG1114	Component of the transport system for branched-chain amino acids
BK049_RS14000	COG1114	Component of the transport system for branched-chain amino acids
BK049_RS14005	COG1104	cysteine desulfurase activity
BK049_RS14010	COG0301	tRNA thio-modification
BK049_RS14020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK049_RS14040	COG1279	arginine transmembrane transporter activity
BK049_RS14055	COG2249	NAD(P)H dehydrogenase (quinone) activity
BK049_RS14060	COG0402	S-adenosylhomocysteine deaminase activity
BK049_RS14065	COG0577	efflux transmembrane transporter activity
BK049_RS14070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK049_RS14075	COG2197	response regulator
BK049_RS14080	COG4585	Histidine kinase
BK049_RS14085	COG3239	Fatty acid desaturase
BK049_RS14095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BK049_RS14100	COG0616	signal peptide processing
BK049_RS14105	COG1714	RDD family
BK049_RS14115	COG3874	Sporulation protein YtfJ
BK049_RS14120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BK049_RS14125	COG0827	DNA restriction-modification system
BK049_RS14130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BK049_RS14135	COG0521	Mo-molybdopterin cofactor biosynthetic process
BK049_RS14140	COG0137	argininosuccinate synthase activity
BK049_RS14145	COG0165	Argininosuccinate lyase
BK049_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS14160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BK049_RS14165	COG4109	DRTGG domain
BK049_RS14175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK049_RS14195	COG0587	DNA-directed DNA polymerase activity
BK049_RS14200	COG0281	malic enzyme
BK049_RS14205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BK049_RS14210	COG0825	malonyl-CoA metabolic process
BK049_RS14215	COG0205	6-phosphofructokinase activity
BK049_RS14225	COG3030	protein affecting phage T7 exclusion by the F plasmid
BK049_RS14230	COG0628	permease
BK049_RS14235	COG2707	UPF0756 membrane protein
BK049_RS14240	COG0372	Belongs to the citrate synthase family
BK049_RS14245	COG0538	isocitrate dehydrogenase activity
BK049_RS14250	COG0039	L-malate dehydrogenase activity
BK049_RS14255	COG0745	RESPONSE REGULATOR receiver
BK049_RS14260	COG5002	protein histidine kinase activity
BK049_RS14265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK049_RS14265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK049_RS14270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BK049_RS14275	COG1971	Probably functions as a manganese efflux pump
BK049_RS14280	COG0237	dephospho-CoA kinase activity
BK049_RS14285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BK049_RS14290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BK049_RS14300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BK049_RS14305	COG3611	Membrane attachment protein
BK049_RS14310	COG1484	DNA-dependent DNA replication
BK049_RS14315	COG0398	Pfam SNARE associated Golgi protein
BK049_RS14325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK049_RS14335	COG1011	Hydrolase
BK049_RS14340	COG3275	phosphorelay sensor kinase activity
BK049_RS14345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BK049_RS14350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BK049_RS14355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BK049_RS14360	COG3326	Membrane
BK049_RS14370	COG1363	Peptidase, m42
BK049_RS14375	COG1966	Carbon starvation protein
BK049_RS14385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK049_RS14390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BK049_RS14395	COG0072	phenylalanine-tRNA ligase activity
BK049_RS14395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK049_RS14400	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK049_RS14405	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BK049_RS14410	COG1286	toxin biosynthetic process
BK049_RS14415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK049_RS14415	COG1796	DNA polymerase
BK049_RS14420	COG1193	negative regulation of DNA recombination
BK049_RS14425	COG3766	membrane
BK049_RS14435	COG0318	PFAM AMP-dependent synthetase and ligase
BK049_RS14440	COG1309	transcriptional regulator
BK049_RS14445	COG1024	Enoyl-CoA hydratase
BK049_RS14450	COG2086	electron transfer activity
BK049_RS14455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BK049_RS14460	COG3118	belongs to the thioredoxin family
BK049_RS14465	COG0322	excinuclease ABC activity
BK049_RS14470	COG0527	aspartate kinase activity
BK049_RS14485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK049_RS14495	COG1719	4-vinyl reductase, 4VR
BK049_RS14500	COG2009	succinate dehydrogenase
BK049_RS14505	COG1053	succinate dehydrogenase
BK049_RS14510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BK049_RS14515	COG0824	Thioesterase
BK049_RS14525	COG2197	response regulator
BK049_RS14530	COG1846	Transcriptional regulator
BK049_RS14535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BK049_RS14540	COG5401	PFAM Sporulation and spore germination
BK049_RS14545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BK049_RS14550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK049_RS14555	COG0622	Phosphoesterase
BK049_RS14585	COG5444	nuclease activity
BK049_RS14595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK049_RS14600	COG1696	Membrane protein involved in D-alanine export
BK049_RS14605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK049_RS14610	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BK049_RS14615	COG3339	Conserved Protein
BK049_RS14620	COG2706	6-phosphogluconolactonase activity
BK049_RS14625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK049_RS14630	COG0028	Belongs to the TPP enzyme family
BK049_RS14635	COG0440	acetolactate synthase activity
BK049_RS14640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BK049_RS14645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK049_RS14650	COG0473	3-isopropylmalate dehydrogenase activity
BK049_RS14655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BK049_RS14660	COG0066	3-isopropylmalate dehydratase activity
BK049_RS14665	COG1477	protein flavinylation
BK049_RS14665	COG0457	Tetratricopeptide repeat
BK049_RS14670	COG0544	peptidyl-prolyl cis-trans isomerase activity
BK049_RS14675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BK049_RS14680	COG1067	ATP-dependent peptidase activity
BK049_RS14680	COG0470	DNA polymerase III
BK049_RS14685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BK049_RS14690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BK049_RS14700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BK049_RS14705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BK049_RS14710	COG0181	hydroxymethylbilane synthase activity
BK049_RS14715	COG1587	Uroporphyrinogen-III synthase
BK049_RS14720	COG0113	porphobilinogen synthase activity
BK049_RS14725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BK049_RS14730	COG1388	LysM domain
BK049_RS14735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BK049_RS14745	COG0525	valine-tRNA ligase activity
BK049_RS14750	COG0285	dihydrofolate synthase activity
BK049_RS14755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BK049_RS14770	COG0424	maF-like protein
BK049_RS14775	COG2003	Belongs to the UPF0758 family
BK049_RS14780	COG1077	Cell shape determining protein MreB Mrl
BK049_RS14790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BK049_RS14795	COG0850	regulation of cytokinetic process
BK049_RS14800	COG2894	cell division
BK049_RS14805	COG0739	heme binding
BK049_RS14810	COG1994	Peptidase M50
BK049_RS14815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BK049_RS14820	COG2868	ribosomal protein
BK049_RS14825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BK049_RS14830	COG3290	protein histidine kinase activity
BK049_RS14835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK049_RS14840	COG4492	Belongs to the UPF0735 family
BK049_RS14845	COG0077	Prephenate dehydratase
BK049_RS14850	COG1827	regulation of RNA biosynthetic process
BK049_RS14855	COG1104	cysteine desulfurase activity
BK049_RS14860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BK049_RS14865	COG0157	Belongs to the NadC ModD family
BK049_RS14870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BK049_RS14875	COG1388	LysM domain
BK049_RS14895	COG2112	serine threonine protein kinase
BK049_RS14905	COG0632	four-way junction helicase activity
BK049_RS14910	COG2255	four-way junction helicase activity
BK049_RS14920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BK049_RS14925	COG0343	queuine tRNA-ribosyltransferase activity
BK049_RS14930	COG1862	Preprotein translocase
BK049_RS14940	COG2323	membrane
BK049_RS14945	COG2244	polysaccharide biosynthetic process
BK049_RS14955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK049_RS14955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK049_RS14960	COG0490	domain, Protein
BK049_RS14965	COG5416	Lipopolysaccharide assembly protein A domain
BK049_RS14970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BK049_RS14970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BK049_RS14975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK049_RS14980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BK049_RS14985	COG1490	D-aminoacyl-tRNA deacylase activity
BK049_RS14990	COG3103	Sh3 type 3 domain protein
BK049_RS14990	COG4991	sh3 domain protein
BK049_RS14990	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK049_RS14995	COG0124	histidyl-tRNA synthetase
BK049_RS15010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BK049_RS15015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BK049_RS15020	COG1959	2 iron, 2 sulfur cluster binding
BK049_RS15025	COG1104	cysteine desulfurase activity
BK049_RS15030	COG0482	sulfurtransferase activity
BK049_RS15035	COG0457	Tetratricopeptide repeat
BK049_RS15040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BK049_RS15045	COG3881	PFAM PRC-barrel domain
BK049_RS15060	COG0765	amino acid transport
BK049_RS15065	COG0765	amino acid transport
BK049_RS15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS15075	COG1126	abc transporter atp-binding protein
BK049_RS15080	COG0628	permease
BK049_RS15085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BK049_RS15090	COG4472	Bacterial protein of unknown function (DUF965)
BK049_RS15095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BK049_RS15100	COG3906	Belongs to the UPF0473 family
BK049_RS15105	COG0183	Belongs to the thiolase family
BK049_RS15110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BK049_RS15115	COG4122	O-methyltransferase activity
BK049_RS15120	COG0826	peptidase U32
BK049_RS15125	COG0826	peptidase U32
BK049_RS15130	COG0572	uridine kinase
BK049_RS15135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BK049_RS15140	COG0768	penicillin binding
BK049_RS15155	COG2226	methyltransferase
BK049_RS15160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BK049_RS15165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK049_RS15170	COG0626	cystathionine gamma-synthase activity
BK049_RS15185	COG2226	methyltransferase
BK049_RS15190	COG1063	alcohol dehydrogenase
BK049_RS15195	COG2226	methyltransferase
BK049_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS15210	COG1063	alcohol dehydrogenase
BK049_RS15220	COG0765	amino acid transport
BK049_RS15225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS15230	COG1126	abc transporter atp-binding protein
BK049_RS15235	COG1960	acyl-CoA dehydrogenase activity
BK049_RS15310	COG0657	acetylesterase activity
BK049_RS15315	COG1733	regulation of RNA biosynthetic process
BK049_RS15320	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BK049_RS15325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BK049_RS15380	COG1518	maintenance of DNA repeat elements
BK049_RS15385	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BK049_RS15410	COG0457	Tetratricopeptide repeat
BK049_RS15420	COG2755	lipolytic protein G-D-S-L family
BK049_RS15430	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BK049_RS15435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BK049_RS15440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK049_RS15445	COG1534	Rna-binding protein
BK049_RS15450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BK049_RS15455	COG1713	HD superfamily hydrolase involved in NAD metabolism
BK049_RS15460	COG0799	negative regulation of ribosome biogenesis
BK049_RS15465	COG2226	methyltransferase
BK049_RS15470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK049_RS15475	COG1596	polysaccharide export
BK049_RS15475	COG1555	photosystem II stabilization
BK049_RS15480	COG2131	deaminase
BK049_RS15485	COG0658	competence protein
BK049_RS15485	COG2333	competence protein COMEC
BK049_RS15495	COG1466	dna polymerase III delta subunit
BK049_RS15500	COG0268	Binds directly to 16S ribosomal RNA
BK049_RS15505	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BK049_RS15510	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK049_RS15520	COG0481	GTPase activity
BK049_RS15525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK049_RS15530	COG1420	regulation of RNA biosynthetic process
BK049_RS15535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BK049_RS15540	COG0443	Heat shock 70 kDa protein
BK049_RS15545	COG0484	heat shock protein binding
BK049_RS15550	COG2264	protein methyltransferase activity
BK049_RS15555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BK049_RS15560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK049_RS15565	COG1283	sodium-dependent phosphate transmembrane transporter activity
BK049_RS15575	COG1610	YqeY-like protein
BK049_RS15580	COG1030	water channel activity
BK049_RS15585	COG4864	UPF0365 protein
BK049_RS15600	COG0561	phosphatase activity
BK049_RS15605	COG1702	phosphate starvation-inducible protein PhoH
BK049_RS15610	COG1480	7TM receptor with intracellular HD hydrolase
BK049_RS15615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BK049_RS15620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BK049_RS15625	COG0295	cytidine deaminase activity
BK049_RS15630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BK049_RS15640	COG1381	Involved in DNA repair and RecF pathway recombination
BK049_RS15645	COG0752	glycyl-tRNA synthetase alpha subunit
BK049_RS15650	COG0751	glycine-tRNA ligase activity
BK049_RS15655	COG0517	IMP dehydrogenase activity
BK049_RS15660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BK049_RS15665	COG1671	Belongs to the UPF0178 family
BK049_RS15670	COG0358	DNA primase activity
BK049_RS15675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK049_RS15680	COG2010	Cytochrome c
BK049_RS15685	COG2384	SAM-dependent methyltransferase
BK049_RS15690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BK049_RS15695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BK049_RS15705	COG0513	Belongs to the DEAD box helicase family
BK049_RS15720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK049_RS15725	COG1121	(ABC) transporter
BK049_RS15730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK049_RS15735	COG0735	belongs to the Fur family
BK049_RS15740	COG1940	carbohydrate kinase activity
BK049_RS15745	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BK049_RS15750	COG4709	membrane
BK049_RS15755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BK049_RS15760	COG1388	LysM domain
BK049_RS15765	COG5521	maltodextrose utilization protein MalA
BK049_RS15770	COG2839	Protein conserved in bacteria
BK049_RS15775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BK049_RS15780	COG0477	Major facilitator Superfamily
BK049_RS15785	COG0768	penicillin binding
BK049_RS15790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BK049_RS15795	COG0573	inorganic phosphate transmembrane transporter activity
BK049_RS15800	COG0581	inorganic phosphate transmembrane transporter activity
BK049_RS15805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK049_RS15810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK049_RS15815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BK049_RS15825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK049_RS15830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BK049_RS15840	COG0457	Tetratricopeptide repeat
BK049_RS15840	COG0705	Rhomboid family
BK049_RS15845	COG4483	Protein conserved in bacteria
BK049_RS15850	COG1940	carbohydrate kinase activity
BK049_RS15855	COG1368	sulfuric ester hydrolase activity
BK049_RS15860	COG2866	Carboxypeptidase
BK049_RS15865	COG2814	Major facilitator Superfamily
BK049_RS15870	COG0011	TIGRFAM Protein of
BK049_RS15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK049_RS15890	COG1393	Belongs to the ArsC family
BK049_RS15900	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS15905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BK049_RS15910	COG1459	type II secretion system
BK049_RS15915	COG4537	Required for transformation and DNA binding
BK049_RS15920	COG4970	Tfp pilus assembly protein FimT
BK049_RS15955	COG0681	Belongs to the peptidase S26 family
BK049_RS15975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BK049_RS15980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BK049_RS15985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK049_RS15990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK049_RS15995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK049_RS16000	COG0095	Lipoate-protein ligase
BK049_RS16005	COG1321	iron dependent repressor
BK049_RS16010	COG1752	Esterase of the alpha-beta hydrolase superfamily
BK049_RS16020	COG3872	metal-dependent enzyme
BK049_RS16030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BK049_RS16035	COG0006	proline dipeptidase activity
BK049_RS16040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BK049_RS16050	COG3854	ATPases associated with a variety of cellular activities
BK049_RS16090	COG0511	ligase activity, forming carbon-carbon bonds
BK049_RS16095	COG0439	Biotin carboxylase
BK049_RS16100	COG1302	Protein conserved in bacteria
BK049_RS16105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BK049_RS16110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BK049_RS16115	COG1570	exodeoxyribonuclease VII activity
BK049_RS16120	COG1722	exodeoxyribonuclease VII activity
BK049_RS16125	COG0142	geranyltranstransferase activity
BK049_RS16130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK049_RS16135	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BK049_RS16140	COG1438	arginine binding
BK049_RS16145	COG0497	DNA recombination
BK049_RS16150	COG0750	zinc metalloprotease
BK049_RS16155	COG0745	RESPONSE REGULATOR receiver
BK049_RS16165	COG0457	Tetratricopeptide repeat
BK049_RS16170	COG0584	glycerophosphoryl diester phosphodiesterase
BK049_RS16180	COG3829	transcription factor binding
BK049_RS16180	COG3290	protein histidine kinase activity
BK049_RS16185	COG0280	phosphate acetyltransferase
BK049_RS16190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK049_RS16195	COG3426	butyrate kinase activity
BK049_RS16200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK049_RS16205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BK049_RS16210	COG0022	dehydrogenase e1 component
BK049_RS16215	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK049_RS16225	COG1597	lipid kinase activity
BK049_RS16235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK049_RS16240	COG0765	amino acid transport
BK049_RS16245	COG1126	abc transporter atp-binding protein
BK049_RS16250	COG4129	membrane
BK049_RS16255	COG1376	ErfK ybiS ycfS ynhG family protein
BK049_RS16260	COG0346	lactoylglutathione lyase activity
BK049_RS16265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BK049_RS16270	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK049_RS16275	COG0835	chemotaxis
BK049_RS16280	COG0706	membrane insertase activity
BK049_RS16290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK049_RS16295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BK049_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
BK049_RS16310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS16315	COG1447	Phosphotransferase system cellobiose-specific component IIA
BK049_RS16320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BK049_RS16325	COG2723	6-phospho-beta-galactosidase activity
BK049_RS16330	COG2188	Transcriptional regulator
BK049_RS16335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BK049_RS16345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK049_RS16350	COG0596	Alpha beta hydrolase
BK049_RS16355	COG1902	pentaerythritol trinitrate reductase activity
BK049_RS16360	COG4187	Peptidase family M20/M25/M40
BK049_RS16365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK049_RS16380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK049_RS16385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK049_RS16390	COG0300	oxidoreductase activity
BK049_RS16395	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK049_RS16400	COG1072	(Pantothenic acid kinase))
BK049_RS16405	COG2211	Major facilitator Superfamily
BK049_RS16415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK049_RS16425	COG0456	acetyltransferase
BK049_RS16430	COG0456	acetyltransferase
BK049_RS16430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK049_RS16435	COG4918	Iron-sulphur cluster biosynthesis
BK049_RS16445	COG0457	Tetratricopeptide repeat
BK049_RS16450	COG1073	alpha beta
BK049_RS16460	COG0667	Aldo Keto reductase
BK049_RS16465	COG0494	nUDIX hydrolase
BK049_RS16470	COG1379	DNA repair
BK049_RS16475	COG2153	protein acetylation
BK049_RS16485	COG1404	Belongs to the peptidase S8 family
BK049_RS16490	COG1300	Membrane
BK049_RS16495	COG0735	belongs to the Fur family
BK049_RS16505	COG4974	Belongs to the 'phage' integrase family
BK049_RS16510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BK049_RS16515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BK049_RS16520	COG1686	Belongs to the peptidase S11 family
BK049_RS16525	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS16530	COG2172	sigma factor antagonist activity
BK049_RS16535	COG1191	sigma factor activity
BK049_RS16570	COG2801	Transposase and inactivated derivatives
BK049_RS16590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BK049_RS16605	COG0697	spore germination
BK049_RS16610	COG0019	diaminopimelate decarboxylase activity
BK049_RS16615	COG4086	secreted protein
BK049_RS16620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BK049_RS16635	COG0307	riboflavin synthase, alpha
BK049_RS16645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BK049_RS16650	COG0456	acetyltransferase
BK049_RS16655	COG1547	Domain of unknown function (DUF309)
BK049_RS16660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BK049_RS16665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BK049_RS16675	COG1686	Belongs to the peptidase S11 family
BK049_RS16680	COG2715	membrane protein required for spore maturation
BK049_RS16685	COG0700	Nucleoside recognition
BK049_RS16690	COG1187	pseudouridine synthase activity
BK049_RS16695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS16700	COG1333	cytochrome c biogenesis protein
BK049_RS16705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BK049_RS16710	COG0745	RESPONSE REGULATOR receiver
BK049_RS16715	COG5002	protein histidine kinase activity
BK049_RS16720	COG1595	DNA-templated transcription, initiation
BK049_RS16735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK049_RS16740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BK049_RS16745	COG1141	Ferredoxin
BK049_RS16750	COG4955	Helix-turn-helix domain
BK049_RS16755	COG0514	ATP-dependent DNA helicase (RecQ)
BK049_RS16760	COG1266	CAAX protease self-immunity
BK049_RS16765	COG1388	LysM domain
BK049_RS16775	COG1408	metallophosphoesterase
BK049_RS16780	COG4862	establishment of competence for transformation
BK049_RS16785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK049_RS16790	COG0492	ferredoxin-NADP+ reductase activity
BK049_RS16795	COG2339	peptidase activity
BK049_RS16800	COG3773	Cell wall hydrolase
BK049_RS16800	COG3409	Peptidoglycan-binding domain 1 protein
BK049_RS16805	COG2959	enzyme of heme biosynthesis
BK049_RS16810	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BK049_RS16820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK049_RS16825	COG0539	negative regulation of cytoplasmic translation
BK049_RS16830	COG1304	FMN binding
BK049_RS16855	COG1160	GTP binding
BK049_RS16860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK049_RS16875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BK049_RS16880	COG0776	regulation of translation
BK049_RS16885	COG0302	gtp cyclohydrolase
BK049_RS16895	COG0142	geranyltranstransferase activity
BK049_RS16900	COG2226	methyltransferase
BK049_RS16905	COG0142	geranyltranstransferase activity
BK049_RS16910	COG0105	UTP biosynthetic process
BK049_RS16915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BK049_RS16920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK049_RS16925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BK049_RS16930	COG4401	Chorismate mutase type I
BK049_RS16945	COG0134	indole-3-glycerol-phosphate synthase activity
BK049_RS16955	COG0133	tryptophan synthase activity
BK049_RS16960	COG0159	tryptophan synthase activity
BK049_RS16965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BK049_RS16970	COG0287	Prephenate dehydrogenase
BK049_RS16975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK049_RS16980	COG0457	Tetratricopeptide repeat
BK049_RS16985	COG5582	Belongs to the UPF0302 family
BK049_RS16995	COG0723	plastoquinol--plastocyanin reductase activity
BK049_RS17000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BK049_RS17005	COG2010	Cytochrome c
BK049_RS17005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BK049_RS17010	COG4347	Protein of unknown function (DUF1405)
BK049_RS17020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK049_RS17025	COG1694	Mazg nucleotide pyrophosphohydrolase
BK049_RS17030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BK049_RS17035	COG1803	Methylglyoxal synthase
BK049_RS17040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BK049_RS17045	COG0438	transferase activity, transferring glycosyl groups
BK049_RS17050	COG0617	tRNA 3'-terminal CCA addition
BK049_RS17060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BK049_RS17065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BK049_RS17070	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BK049_RS17075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BK049_RS17075	COG1199	ATP-dependent helicase activity
BK049_RS17085	COG5353	protein conserved in bacteria
BK049_RS17090	COG0017	Asparaginyl-tRNA synthetase
BK049_RS17095	COG3935	DnaD domain protein
BK049_RS17100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BK049_RS17110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK049_RS17110	COG4499	WXG100 protein secretion system (Wss), protein YukC
BK049_RS17115	COG3331	DNA recombination
BK049_RS17145	COG0071	Belongs to the small heat shock protein (HSP20) family
BK049_RS17150	COG2190	(PTS) system
BK049_RS17155	COG2801	Transposase and inactivated derivatives
BK049_RS17165	COG1902	pentaerythritol trinitrate reductase activity
BK049_RS17170	COG1111	helicase
BK049_RS17170	COG1205	dead DEAH box helicase
BK049_RS17175	COG3359	exonuclease
BK049_RS17180	COG4474	Belongs to the UPF0398 family
BK049_RS17185	COG3599	regulation of cell shape
BK049_RS17195	COG0116	Belongs to the methyltransferase superfamily
BK049_RS17205	COG1199	ATP-dependent helicase activity
BK049_RS17210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BK049_RS17215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK049_RS17220	COG2233	PERMEase
BK049_RS17230	COG1755	Isoprenylcysteine carboxyl methyltransferase
BK049_RS17235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BK049_RS17245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK049_RS17255	COG0328	RNA-DNA hybrid ribonuclease activity
BK049_RS17260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BK049_RS17265	COG0328	RNA-DNA hybrid ribonuclease activity
BK049_RS17280	COG1278	Cold shock
BK049_RS17290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK049_RS17295	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BK049_RS17300	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BK049_RS17305	COG0386	Belongs to the glutathione peroxidase family
BK049_RS17310	COG1418	mRNA catabolic process
BK049_RS17315	COG1413	lyase activity
BK049_RS17320	COG0129	dihydroxy-acid dehydratase activity
BK049_RS17330	COG2136	Putative SAM-dependent methyltransferase
BK049_RS17330	COG2521	methyltransferase
BK049_RS17340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK049_RS17345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK049_RS17350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK049_RS17355	COG0204	Acyl-transferase
BK049_RS17360	COG1272	protein, Hemolysin III
BK049_RS17365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BK049_RS17370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BK049_RS17385	COG1999	signal sequence binding
BK049_RS17390	COG2755	lipolytic protein G-D-S-L family
BK049_RS17395	COG4698	Protein conserved in bacteria
BK049_RS17415	COG1846	Transcriptional regulator
BK049_RS17420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK049_RS17425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK049_RS17430	COG1086	Polysaccharide biosynthesis protein
BK049_RS17440	COG4641	Protein conserved in bacteria
BK049_RS17455	COG0463	Glycosyl transferase, family 2
BK049_RS17460	COG3829	transcription factor binding
BK049_RS17465	COG1509	lysine 2,3-aminomutase activity
BK049_RS17475	COG4479	Belongs to the UPF0346 family
BK049_RS17490	COG0671	phosphoesterase, PA-phosphatase related
BK049_RS17500	COG0813	purine-nucleoside phosphorylase activity
BK049_RS17505	COG1876	peptidase activity
BK049_RS17515	COG2226	methyltransferase
BK049_RS17520	COG0793	Belongs to the peptidase S41A family
BK049_RS17520	COG3409	Peptidoglycan-binding domain 1 protein
BK049_RS17525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK049_RS17535	COG0778	Nitroreductase
BK049_RS17540	COG1733	regulation of RNA biosynthetic process
BK049_RS17555	COG2962	Rard protein
BK049_RS17565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BK049_RS17570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BK049_RS17580	COG0534	Mate efflux family protein
BK049_RS17585	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BK049_RS17590	COG0791	NLP P60 protein
BK049_RS17590	COG1388	LysM domain
BK049_RS17595	COG2032	superoxide dismutase activity
BK049_RS17600	COG0714	Associated with various cellular activities
BK049_RS17605	COG4548	von Willebrand factor, type A
BK049_RS17610	COG0567	Dehydrogenase, E1 component
BK049_RS17615	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK049_RS17620	COG0385	Bile acid
BK049_RS17625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BK049_RS17630	COG1657	PFAM Prenyltransferase squalene oxidase
BK049_RS17635	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS17655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BK049_RS17665	COG0514	ATP-dependent DNA helicase (RecQ)
BK049_RS17670	COG3584	3D domain protein
BK049_RS17670	COG1388	LysM domain
BK049_RS17680	COG2322	membrane
BK049_RS17685	COG0372	Belongs to the citrate synthase family
BK049_RS17690	COG2079	MmgE PrpD family protein
BK049_RS17695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BK049_RS17700	COG0741	lytic transglycosylase activity
BK049_RS17705	COG0531	amino acid
BK049_RS17710	COG0640	Transcriptional regulator
BK049_RS17720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK049_RS17725	COG1309	transcriptional regulator
BK049_RS17745	COG1994	Peptidase M50
BK049_RS17750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK049_RS17755	COG0243	molybdopterin cofactor binding
BK049_RS17765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK049_RS17770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BK049_RS17775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BK049_RS17785	COG1132	(ABC) transporter
BK049_RS17795	COG0583	DNA-binding transcription factor activity
BK049_RS17800	COG0069	glutamate synthase activity
BK049_RS17800	COG0070	glutamate synthase
BK049_RS17800	COG0067	glutamate synthase
BK049_RS17805	COG0493	'glutamate synthase
BK049_RS17810	COG2223	nitrite transmembrane transporter activity
BK049_RS17815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BK049_RS17820	COG0243	molybdopterin cofactor binding
BK049_RS17825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BK049_RS17830	COG2146	nitrite reductase [NAD(P)H] activity
BK049_RS17835	COG2323	membrane
BK049_RS17840	COG4677	pectinesterase activity
BK049_RS17845	COG2027	D-alanyl-D-alanine carboxypeptidase
BK049_RS17850	COG0534	Mate efflux family protein
BK049_RS17855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK049_RS17865	COG1587	Uroporphyrinogen-III synthase
BK049_RS17870	COG0586	Pfam SNARE associated Golgi protein
BK049_RS17875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK049_RS17880	COG2246	polysaccharide biosynthetic process
BK049_RS17885	COG0166	Belongs to the GPI family
BK049_RS17900	COG0247	lactate metabolic process
BK049_RS17905	COG0277	FAD linked oxidase domain protein
BK049_RS17910	COG3835	regulator
BK049_RS17920	COG1349	DNA-binding transcription factor activity
BK049_RS17930	COG1649	PFAM Uncharacterised BCR, COG1649
BK049_RS17935	COG1960	acyl-CoA dehydrogenase activity
BK049_RS17940	COG0318	PFAM AMP-dependent synthetase and ligase
BK049_RS17945	COG0439	Biotin carboxylase
BK049_RS17950	COG0511	ligase activity, forming carbon-carbon bonds
BK049_RS17955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK049_RS17960	COG1024	Enoyl-CoA hydratase
BK049_RS17965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BK049_RS17970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK049_RS17975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BK049_RS17980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BK049_RS17985	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS18005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK049_RS18010	COG2814	Major facilitator Superfamily
BK049_RS18015	COG1846	Transcriptional regulator
BK049_RS18020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK049_RS18035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK049_RS18040	COG1609	Transcriptional regulator
BK049_RS18045	COG1653	transport
BK049_RS18050	COG1175	transmembrane transport
BK049_RS18055	COG0395	ABC-type sugar transport system, permease component
BK049_RS18060	COG1486	melibiose metabolic process
BK049_RS18065	COG1012	belongs to the aldehyde dehydrogenase family
BK049_RS18070	COG3507	Belongs to the glycosyl hydrolase 43 family
BK049_RS18085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK049_RS18090	COG0187	DNA topoisomerase II activity
BK049_RS18095	COG1832	CoA-binding protein
BK049_RS18100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BK049_RS18105	COG4841	protein insertion into membrane
BK049_RS18115	COG0824	Thioesterase
BK049_RS18135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK049_RS18140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BK049_RS18155	COG0071	Belongs to the small heat shock protein (HSP20) family
BK049_RS18165	COG4846	Membrane protein involved in cytochrome C biogenesis
BK049_RS18170	COG0785	Cytochrome C biogenesis protein
BK049_RS18180	COG3763	UPF0154 protein
BK049_RS18190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BK049_RS18195	COG4224	UPF0291 protein
BK049_RS18200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BK049_RS18205	COG1388	LysM domain
BK049_RS18210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BK049_RS18225	COG1366	Belongs to the anti-sigma-factor antagonist family
BK049_RS18230	COG3209	COG3209 Rhs family protein
BK049_RS18235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BK049_RS18240	COG2124	cytochrome p450
BK049_RS18240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BK049_RS18245	COG1309	transcriptional regulator
BK049_RS18250	COG2323	membrane
BK049_RS18265	COG1556	Lactate utilization protein
BK049_RS18270	COG1139	Iron-sulfur cluster binding protein
BK049_RS18275	COG0247	lactate metabolic process
BK049_RS18285	COG0702	epimerase
BK049_RS18290	COG1959	2 iron, 2 sulfur cluster binding
BK049_RS18300	COG4876	unkown
BK049_RS18305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BK049_RS18310	COG3285	dna ligase
BK049_RS18310	COG1793	dna ligase
BK049_RS18315	COG3619	membrane
BK049_RS18325	COG0457	Tetratricopeptide repeat
BK049_RS18345	COG5646	InterPro IPR014922
BK049_RS18355	COG5444	nuclease activity
BK049_RS18380	COG5444	nuclease activity
BK049_RS18385	COG0300	oxidoreductase activity
BK049_RS18410	COG5518	Phage portal protein
BK049_RS18415	COG1783	phage Terminase large subunit
BK049_RS18420	COG5484	DNA packaging
BK049_RS18455	COG5444	nuclease activity
BK049_RS18460	COG4282	regulation of fungal-type cell wall biogenesis
BK049_RS18485	COG0174	glutamine synthetase
BK049_RS18490	COG0789	Transcriptional regulator
BK049_RS18495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BK049_RS18500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BK049_RS18505	COG0464	growth
BK049_RS18515	COG4112	unkown
BK049_RS18520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK049_RS18525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK049_RS18530	COG1780	Probably involved in ribonucleotide reductase function
BK049_RS18545	COG1923	regulation of RNA biosynthetic process
BK049_RS18550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BK049_RS18580	COG1764	response to oxidative stress
BK049_RS18585	COG4195	phage-related replication protein
BK049_RS18590	COG1404	Belongs to the peptidase S8 family
BK049_RS18595	COG0457	Tetratricopeptide repeat
BK049_RS18600	COG4195	phage-related replication protein
BK049_RS18605	COG1329	Transcriptional regulator