locus-tag	class	description
HOS37_gp048	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HOS37_gp066	COG4695	Portal protein
HOS37_gp085	COG0756	dUTP diphosphatase activity
HOS37_gp086	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOS37_gp094	COG0358	DNA primase activity
HOS37_gp097	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOS37_gp098	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOS37_gp111	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HOS37_gp116	COG1328	CTP reductase activity
HOS37_gp117	COG1702	phosphate starvation-inducible protein PhoH
HOS37_gp119	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOS37_gp123	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HOS37_gp126	COG0328	RNA-DNA hybrid ribonuclease activity
HOS37_gp140	COG3172	ATPase kinase involved in NAD metabolism