locus-tag	class	description
CHH28_RS00015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS00035	COG1490	D-aminoacyl-tRNA deacylase activity
CHH28_RS00045	COG3852	Histidine kinase
CHH28_RS00050	COG2204	response regulator
CHH28_RS00085	COG2165	general secretion pathway protein
CHH28_RS00095	COG1459	type II secretion system
CHH28_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHH28_RS00110	COG3267	Type II secretory pathway component ExeA
CHH28_RS00110	COG3409	Peptidoglycan-binding domain 1 protein
CHH28_RS00115	COG1450	Type ii and iii secretion system protein
CHH28_RS00135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CHH28_RS00140	COG2133	pyrroloquinoline quinone binding
CHH28_RS00145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CHH28_RS00150	COG2890	protein-(glutamine-N5) methyltransferase activity
CHH28_RS00155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHH28_RS00160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CHH28_RS00170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CHH28_RS00175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CHH28_RS00190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CHH28_RS00195	COG0193	aminoacyl-tRNA hydrolase activity
CHH28_RS00205	COG2814	Major facilitator Superfamily
CHH28_RS00210	COG1309	transcriptional regulator
CHH28_RS00220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHH28_RS00225	COG1702	phosphate starvation-inducible protein PhoH
CHH28_RS00230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CHH28_RS00235	COG4535	Mg2 and Co2 transporter CorC
CHH28_RS00245	COG2186	Transcriptional regulator
CHH28_RS00265	COG0653	protein targeting
CHH28_RS00270	COG0739	heme binding
CHH28_RS00275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CHH28_RS00295	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHH28_RS00300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHH28_RS00305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHH28_RS00310	COG0772	Belongs to the SEDS family
CHH28_RS00315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHH28_RS00320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHH28_RS00325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHH28_RS00330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHH28_RS00345	COG0275	rRNA processing
CHH28_RS00365	COG0156	8-amino-7-oxononanoate synthase activity
CHH28_RS00370	COG0596	Alpha beta hydrolase
CHH28_RS00370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHH28_RS00370	COG2226	methyltransferase
CHH28_RS00375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CHH28_RS00385	COG0450	alkyl hydroperoxide reductase
CHH28_RS00405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CHH28_RS00410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CHH28_RS00430	COG1185	polyribonucleotide nucleotidyltransferase activity
CHH28_RS00435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHH28_RS00440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHH28_RS00445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHH28_RS00455	COG0195	Participates in both transcription termination and antitermination
CHH28_RS00460	COG0779	Required for maturation of 30S ribosomal subunits
CHH28_RS00475	COG0149	triose-phosphate isomerase activity
CHH28_RS00480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHH28_RS00485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CHH28_RS00490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHH28_RS00495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CHH28_RS00515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHH28_RS00540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHH28_RS00545	COG0484	heat shock protein binding
CHH28_RS00550	COG0443	Heat shock 70 kDa protein
CHH28_RS00555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CHH28_RS00560	COG0497	DNA recombination
CHH28_RS00575	COG2914	Belongs to the UPF0125 (RnfH) family
CHH28_RS00580	COG2867	negative regulation of translational initiation
CHH28_RS00585	COG0733	neurotransmitter:sodium symporter activity
CHH28_RS00590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CHH28_RS00625	COG0745	RESPONSE REGULATOR receiver
CHH28_RS00635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CHH28_RS00645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHH28_RS00665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHH28_RS00670	COG1522	sequence-specific DNA binding
CHH28_RS00680	COG3724	N-succinylarginine dihydrolase activity
CHH28_RS00700	COG1012	belongs to the aldehyde dehydrogenase family
CHH28_RS00710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHH28_RS00720	COG2988	succinylglutamate desuccinylase activity
CHH28_RS00725	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CHH28_RS00745	COG1269	ATP hydrolysis coupled proton transport
CHH28_RS00750	COG1394	ATPase activity, coupled to movement of substances
CHH28_RS00770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CHH28_RS00800	COG0583	DNA-binding transcription factor activity
CHH28_RS00810	COG4948	Mandelate Racemase Muconate Lactonizing
CHH28_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
CHH28_RS00820	COG0747	negative chemotaxis
CHH28_RS00830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHH28_RS00850	COG3046	protein related to deoxyribodipyrimidine photolyase
CHH28_RS00860	COG0415	Belongs to the DNA photolyase family
CHH28_RS00865	COG0415	Belongs to the DNA photolyase family
CHH28_RS00895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CHH28_RS00905	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CHH28_RS00930	COG0456	acetyltransferase
CHH28_RS00940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHH28_RS00965	COG0840	transmembrane signaling receptor activity
CHH28_RS00970	COG0840	transmembrane signaling receptor activity
CHH28_RS01005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHH28_RS01025	COG0840	transmembrane signaling receptor activity
CHH28_RS01035	COG0402	S-adenosylhomocysteine deaminase activity
CHH28_RS01075	COG3845	ABC transporter
CHH28_RS01080	COG4603	Belongs to the binding-protein-dependent transport system permease family
CHH28_RS01100	COG1309	transcriptional regulator
CHH28_RS01130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHH28_RS01160	COG0004	ammonium transporteR
CHH28_RS01165	COG4109	DRTGG domain
CHH28_RS01170	COG1611	Belongs to the LOG family
CHH28_RS01185	COG2154	pterin-4-alpha-carbinolamine dehydratase
CHH28_RS01190	COG3813	Protein conserved in bacteria
CHH28_RS01195	COG2814	Major facilitator Superfamily
CHH28_RS01210	COG1785	Belongs to the alkaline phosphatase family
CHH28_RS01260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CHH28_RS01290	COG0840	transmembrane signaling receptor activity
CHH28_RS01300	COG2827	Endonuclease containing a URI domain
CHH28_RS01305	COG1272	protein, Hemolysin III
CHH28_RS01320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CHH28_RS01325	COG3178	'Phosphotransferase
CHH28_RS01330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CHH28_RS01335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHH28_RS01340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CHH28_RS01345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHH28_RS01350	COG2967	ApaG domain
CHH28_RS01355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHH28_RS01360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHH28_RS01365	COG2766	serine protein kinase
CHH28_RS01370	COG2718	Belongs to the UPF0229 family
CHH28_RS01375	COG2719	SpoVR family
CHH28_RS01395	COG0617	tRNA 3'-terminal CCA addition
CHH28_RS01405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CHH28_RS01410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHH28_RS01415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHH28_RS01425	COG0358	DNA primase activity
CHH28_RS01430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHH28_RS01450	COG0339	signal peptide processing
CHH28_RS01455	COG1956	GAF domain-containing protein
CHH28_RS01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHH28_RS01500	COG1595	DNA-templated transcription, initiation
CHH28_RS01550	COG0625	glutathione transferase activity
CHH28_RS01560	COG2153	protein acetylation
CHH28_RS01570	COG4206	TonB-dependent receptor
CHH28_RS01580	COG1404	Belongs to the peptidase S8 family
CHH28_RS01600	COG2873	o-acetylhomoserine
CHH28_RS01605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CHH28_RS01610	COG1320	monovalent cation:proton antiporter activity
CHH28_RS01615	COG2212	antiporter activity
CHH28_RS01620	COG1863	multisubunit Na H antiporter MnhE subunit
CHH28_RS01625	COG0651	ATP synthesis coupled electron transport
CHH28_RS01630	COG1006	Multisubunit Na H antiporter MnhC subunit
CHH28_RS01635	COG2111	Na H antiporter
CHH28_RS01635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHH28_RS01640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CHH28_RS01650	COG0493	'glutamate synthase
CHH28_RS01655	COG0069	glutamate synthase activity
CHH28_RS01655	COG0070	glutamate synthase
CHH28_RS01655	COG0067	glutamate synthase
CHH28_RS01665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHH28_RS01705	COG0277	FAD linked oxidase domain protein
CHH28_RS01710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHH28_RS01715	COG0107	imidazoleglycerol-phosphate synthase activity
CHH28_RS01720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CHH28_RS01725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CHH28_RS01730	COG0131	Imidazoleglycerol-phosphate dehydratase
CHH28_RS01760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CHH28_RS01795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHH28_RS01820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CHH28_RS01850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHH28_RS01865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHH28_RS01870	COG1215	transferase activity, transferring glycosyl groups
CHH28_RS01890	COG0463	Glycosyl transferase, family 2
CHH28_RS01945	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS01950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CHH28_RS01995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHH28_RS02025	COG1283	sodium-dependent phosphate transmembrane transporter activity
CHH28_RS02045	COG2119	membrane
CHH28_RS02050	COG2207	Transcriptional regulator
CHH28_RS02060	COG4302	ethanolamine ammonia-lyase activity
CHH28_RS02065	COG0531	amino acid
CHH28_RS02075	COG1902	pentaerythritol trinitrate reductase activity
CHH28_RS02075	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHH28_RS02080	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS02100	COG1404	Belongs to the peptidase S8 family
CHH28_RS02140	COG0076	glutamate decarboxylase activity
CHH28_RS02145	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CHH28_RS02180	COG1288	antiporter activity
CHH28_RS02185	COG2235	arginine
CHH28_RS02190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHH28_RS02205	COG2346	COG2346, Truncated hemoglobins
CHH28_RS02220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CHH28_RS02225	COG1687	branched-chain amino acid
CHH28_RS02305	COG1231	oxidoreductase activity
CHH28_RS02320	COG0527	aspartate kinase activity
CHH28_RS02325	COG1917	Cupin 2, conserved barrel domain protein
CHH28_RS02345	COG1846	Transcriptional regulator
CHH28_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS02380	COG2366	antibiotic biosynthetic process
CHH28_RS02395	COG0745	RESPONSE REGULATOR receiver
CHH28_RS02400	COG2205	protein histidine kinase activity
CHH28_RS02430	COG0583	DNA-binding transcription factor activity
CHH28_RS02440	COG3148	PFAM DTW domain containing protein
CHH28_RS02465	COG2226	methyltransferase
CHH28_RS02475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CHH28_RS02480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CHH28_RS02485	COG0140	phosphoribosyl-ATP diphosphatase activity
CHH28_RS02490	COG0537	adenosine 5'-monophosphoramidase activity
CHH28_RS02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHH28_RS02500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHH28_RS02515	COG4191	Histidine kinase
CHH28_RS02530	COG2373	Large extracellular alpha-helical protein
CHH28_RS02535	COG4953	penicillin-binding protein 1C
CHH28_RS02545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHH28_RS02555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHH28_RS02575	COG3273	potassium ion transport
CHH28_RS02575	COG0471	metal ion transport
CHH28_RS02605	COG0737	Belongs to the 5'-nucleotidase family
CHH28_RS02615	COG0583	DNA-binding transcription factor activity
CHH28_RS02635	COG3708	Transcriptional regulator
CHH28_RS02635	COG2207	Transcriptional regulator
CHH28_RS02650	COG0384	phenazine biosynthesis protein PhzF
CHH28_RS02680	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS02730	COG1858	cytochrome C peroxidase
CHH28_RS02805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CHH28_RS02830	COG1505	serine-type exopeptidase activity
CHH28_RS02835	COG0129	dihydroxy-acid dehydratase activity
CHH28_RS02880	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS02910	COG1136	(ABC) transporter
CHH28_RS02920	COG4591	ABC-type transport system involved in lipoprotein release permease component
CHH28_RS02940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHH28_RS02950	COG1690	Belongs to the RtcB family
CHH28_RS02955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CHH28_RS02960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CHH28_RS02965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CHH28_RS02985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHH28_RS02990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHH28_RS02995	COG2003	Belongs to the UPF0758 family
CHH28_RS03000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHH28_RS03005	COG0756	dUTP diphosphatase activity
CHH28_RS03015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CHH28_RS03020	COG1309	transcriptional regulator
CHH28_RS03030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHH28_RS03040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CHH28_RS03045	COG1561	YicC-like family, N-terminal region
CHH28_RS03070	COG1758	RNA polymerase activity
CHH28_RS03075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHH28_RS03085	COG0730	response to heat
CHH28_RS03095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CHH28_RS03145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CHH28_RS03145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CHH28_RS03155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHH28_RS03170	COG0745	RESPONSE REGULATOR receiver
CHH28_RS03175	COG1560	Kdo2-lipid A biosynthetic process
CHH28_RS03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CHH28_RS03190	COG1519	Transferase
CHH28_RS03195	COG1538	Outer membrane efflux protein
CHH28_RS03200	COG0494	nUDIX hydrolase
CHH28_RS03210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CHH28_RS03215	COG3150	esterase
CHH28_RS03245	COG1741	Belongs to the pirin family
CHH28_RS03270	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CHH28_RS03275	COG0494	nUDIX hydrolase
CHH28_RS03290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CHH28_RS03300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHH28_RS03305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CHH28_RS03310	COG0006	proline dipeptidase activity
CHH28_RS03335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHH28_RS03365	COG1217	gtp-binding protein TYPA
CHH28_RS03385	COG1842	Phage shock protein A
CHH28_RS03400	COG3766	membrane
CHH28_RS03410	COG0754	glutathionylspermidine amidase activity
CHH28_RS03415	COG0281	malic enzyme
CHH28_RS03425	COG0745	RESPONSE REGULATOR receiver
CHH28_RS03430	COG0628	permease
CHH28_RS03445	COG1346	cytolysis
CHH28_RS03450	COG2205	protein histidine kinase activity
CHH28_RS03450	COG0784	Response regulator, receiver
CHH28_RS03455	COG0494	nUDIX hydrolase
CHH28_RS03460	COG1011	Hydrolase
CHH28_RS03465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CHH28_RS03470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CHH28_RS03475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CHH28_RS03480	COG0667	Aldo Keto reductase
CHH28_RS03485	COG0583	DNA-binding transcription factor activity
CHH28_RS03490	COG2183	response to ionizing radiation
CHH28_RS03495	COG2918	glutathione biosynthetic process
CHH28_RS03505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CHH28_RS03540	COG0488	(ABC) transporter
CHH28_RS03550	COG0783	Belongs to the Dps family
CHH28_RS03555	COG0494	nUDIX hydrolase
CHH28_RS03565	COG0596	Alpha beta hydrolase
CHH28_RS03605	COG2910	NAD(P)H-binding
CHH28_RS03610	COG0583	DNA-binding transcription factor activity
CHH28_RS03650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHH28_RS03655	COG2363	Small membrane protein
CHH28_RS03660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CHH28_RS03670	COG0668	transmembrane transport
CHH28_RS03680	COG2200	EAL domain
CHH28_RS03705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CHH28_RS03720	COG1228	amidohydrolase
CHH28_RS03725	COG2188	Transcriptional regulator
CHH28_RS03730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CHH28_RS03735	COG2986	histidine ammonia-lyase
CHH28_RS03770	COG5002	protein histidine kinase activity
CHH28_RS03770	COG0784	Response regulator, receiver
CHH28_RS03770	COG2205	protein histidine kinase activity
CHH28_RS03775	COG3437	response regulator, receiver
CHH28_RS03785	COG2959	enzyme of heme biosynthesis
CHH28_RS03795	COG0181	hydroxymethylbilane synthase activity
CHH28_RS03800	COG1294	oxidase, subunit
CHH28_RS03805	COG1271	oxidase subunit
CHH28_RS03820	COG0165	Argininosuccinate lyase
CHH28_RS03895	COG3023	N-Acetylmuramoyl-L-alanine amidase
CHH28_RS03910	COG0123	including yeast histone deacetylase and acetoin utilization protein
CHH28_RS03925	COG1024	Enoyl-CoA hydratase
CHH28_RS03950	COG4953	penicillin-binding protein 1C
CHH28_RS03960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CHH28_RS03965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHH28_RS03970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHH28_RS03975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHH28_RS03985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHH28_RS03995	COG0356	it plays a direct role in the translocation of protons across the membrane
CHH28_RS04005	COG1475	DNA binding
CHH28_RS04010	COG1192	Involved in chromosome partitioning
CHH28_RS04020	COG0477	Major facilitator Superfamily
CHH28_RS04030	COG1301	dicarboxylic acid transport
CHH28_RS04035	COG1301	dicarboxylic acid transport
CHH28_RS04040	COG2197	response regulator
CHH28_RS04045	COG4585	Histidine kinase
CHH28_RS04140	COG1024	Enoyl-CoA hydratase
CHH28_RS04145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHH28_RS04155	COG4770	biotin carboxylase activity
CHH28_RS04160	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CHH28_RS04165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CHH28_RS04170	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS04210	COG3011	Protein conserved in bacteria
CHH28_RS04220	COG0406	alpha-ribazole phosphatase activity
CHH28_RS04250	COG0789	Transcriptional regulator
CHH28_RS04265	COG0009	L-threonylcarbamoyladenylate synthase
CHH28_RS04275	COG0175	sulfate reduction
CHH28_RS04280	COG3002	Belongs to the UPF0753 family
CHH28_RS04285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CHH28_RS04290	COG0583	DNA-binding transcription factor activity
CHH28_RS04315	COG4774	siderophore transport
CHH28_RS04315	COG1629	transport
CHH28_RS04335	COG3177	Filamentation induced by cAMP protein fic
CHH28_RS04345	COG0445	tRNA wobble uridine modification
CHH28_RS04355	COG1309	transcriptional regulator
CHH28_RS04375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CHH28_RS04380	COG0706	membrane insertase activity
CHH28_RS04390	COG0594	ribonuclease P activity
CHH28_RS04400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHH28_RS04405	COG0592	DNA-directed DNA polymerase activity
CHH28_RS04410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHH28_RS04415	COG0187	DNA topoisomerase II activity
CHH28_RS04420	COG0251	oxidation-reduction process
CHH28_RS04425	COG1280	lysine exporter protein (LysE YggA)
CHH28_RS04435	COG2056	Na+-H+ antiporter family
CHH28_RS04450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CHH28_RS04460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CHH28_RS04470	COG0751	glycine-tRNA ligase activity
CHH28_RS04475	COG0752	glycyl-tRNA synthetase alpha subunit
CHH28_RS04485	COG0745	RESPONSE REGULATOR receiver
CHH28_RS04490	COG1560	Kdo2-lipid A biosynthetic process
CHH28_RS04510	COG1595	DNA-templated transcription, initiation
CHH28_RS04515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHH28_RS04520	COG0569	domain protein
CHH28_RS04535	COG0242	peptide deformylase activity
CHH28_RS04545	COG0758	DNA mediated transformation
CHH28_RS04550	COG0457	Tetratricopeptide repeat
CHH28_RS04555	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CHH28_RS04565	COG1215	transferase activity, transferring glycosyl groups
CHH28_RS04580	COG0745	RESPONSE REGULATOR receiver
CHH28_RS04585	COG0408	coproporphyrinogen oxidase activity
CHH28_RS04600	COG0217	transcriptional regulatory protein
CHH28_RS04605	COG1607	acyl-coa hydrolase
CHH28_RS04610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CHH28_RS04615	COG0573	inorganic phosphate transmembrane transporter activity
CHH28_RS04620	COG0581	inorganic phosphate transmembrane transporter activity
CHH28_RS04625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHH28_RS04710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHH28_RS04715	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CHH28_RS04735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CHH28_RS04740	COG3161	chorismate lyase activity
CHH28_RS04755	COG0776	regulation of translation
CHH28_RS04780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHH28_RS04785	COG0583	DNA-binding transcription factor activity
CHH28_RS04795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHH28_RS04800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CHH28_RS04805	COG0735	belongs to the Fur family
CHH28_RS04810	COG1121	(ABC) transporter
CHH28_RS04815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHH28_RS04825	COG0534	Mate efflux family protein
CHH28_RS04840	COG3038	cytochrome b561
CHH28_RS04845	COG2353	YceI-like domain
CHH28_RS04880	COG0339	signal peptide processing
CHH28_RS04885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CHH28_RS04890	COG0501	Belongs to the peptidase M48B family
CHH28_RS04920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CHH28_RS04935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CHH28_RS04940	COG3245	cytochrome
CHH28_RS04950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHH28_RS04965	COG1349	DNA-binding transcription factor activity
CHH28_RS04990	COG0606	chelatase, subunit chli
CHH28_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS05025	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS05040	COG0439	Biotin carboxylase
CHH28_RS05045	COG1802	Transcriptional regulator
CHH28_RS05065	COG0583	DNA-binding transcription factor activity
CHH28_RS05080	COG1172	Belongs to the binding-protein-dependent transport system permease family
CHH28_RS05085	COG0411	ABC transporter
CHH28_RS05095	COG2885	chlorophyll binding
CHH28_RS05105	COG0456	acetyltransferase
CHH28_RS05115	COG2960	long-chain fatty acid transporting porin activity
CHH28_RS05130	COG0347	Belongs to the P(II) protein family
CHH28_RS05135	COG0004	ammonium transporteR
CHH28_RS05140	COG4106	trans-aconitate 2-methyltransferase activity
CHH28_RS05150	COG4628	conserved protein (DUF2132)
CHH28_RS05160	COG0435	Glutathione S-transferase
CHH28_RS05165	COG2259	Doxx family
CHH28_RS05170	COG0583	DNA-binding transcription factor activity
CHH28_RS05190	COG1737	Transcriptional regulator
CHH28_RS05195	COG0210	DNA helicase
CHH28_RS05200	COG2165	general secretion pathway protein
CHH28_RS05205	COG0742	ribosomal rna small subunit methyltransferase
CHH28_RS05215	COG0552	protein localization to endoplasmic reticulum
CHH28_RS05220	COG2884	Cell division ATP-binding protein ftsE
CHH28_RS05225	COG2177	Part of the ABC transporter FtsEX involved in
CHH28_RS05250	COG0248	Ppx GppA phosphatase
CHH28_RS05270	COG2050	protein possibly involved in aromatic compounds catabolism
CHH28_RS05285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CHH28_RS05310	COG0534	Mate efflux family protein
CHH28_RS05370	COG0314	molybdopterin synthase activity
CHH28_RS05375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CHH28_RS05380	COG0315	cyclic pyranopterin monophosphate synthase activity
CHH28_RS05385	COG0521	Mo-molybdopterin cofactor biosynthetic process
CHH28_RS05390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CHH28_RS05400	COG0501	Belongs to the peptidase M48B family
CHH28_RS05405	COG1704	LemA family
CHH28_RS05425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CHH28_RS05430	COG1166	arginine decarboxylase activity
CHH28_RS05450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CHH28_RS05470	COG0540	Belongs to the ATCase OTCase family
CHH28_RS05475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CHH28_RS05480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHH28_RS05485	COG1678	Uncharacterized ACR, COG1678
CHH28_RS05520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CHH28_RS05525	COG0643	Histidine kinase
CHH28_RS05525	COG2198	Histidine kinase
CHH28_RS05525	COG0784	Response regulator, receiver
CHH28_RS05530	COG2201	protein-glutamate methylesterase activity
CHH28_RS05540	COG3562	capsule polysaccharide
CHH28_RS05570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CHH28_RS05575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CHH28_RS05580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHH28_RS05585	COG0640	Transcriptional regulator
CHH28_RS05590	COG0714	Associated with various cellular activities
CHH28_RS05600	COG1305	Transglutaminase-like
CHH28_RS05640	COG1858	cytochrome C peroxidase
CHH28_RS05645	COG1454	alcohol dehydrogenase
CHH28_RS05655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHH28_RS05665	COG4585	Histidine kinase
CHH28_RS05670	COG2197	response regulator
CHH28_RS05680	COG0121	glutamine amidotransferase
CHH28_RS05700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS05710	COG2205	protein histidine kinase activity
CHH28_RS05750	COG1177	transmembrane transport
CHH28_RS05755	COG1176	ABC-type spermidine putrescine transport system, permease component I
CHH28_RS05760	COG3842	ATPase activity
CHH28_RS05765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CHH28_RS05770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CHH28_RS05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHH28_RS05790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CHH28_RS05795	COG1981	membrane
CHH28_RS05800	COG0038	chloride channel
CHH28_RS05805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CHH28_RS05820	COG0316	Belongs to the HesB IscA family
CHH28_RS05830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CHH28_RS05835	COG0739	heme binding
CHH28_RS05840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHH28_RS05870	COG3706	GGDEF domain
CHH28_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
CHH28_RS05880	COG1119	ATPase activity
CHH28_RS05885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CHH28_RS05895	COG0129	dihydroxy-acid dehydratase activity
CHH28_RS05900	COG3038	cytochrome b561
CHH28_RS05915	COG0642	Histidine kinase
CHH28_RS05925	COG0018	arginyl-trna synthetase
CHH28_RS05940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHH28_RS05960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHH28_RS05965	COG0081	regulation of translation
CHH28_RS05970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHH28_RS05975	COG0222	ribosome binding
CHH28_RS05980	COG0085	RNA polymerase activity
CHH28_RS05990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHH28_RS05995	COG0049	tRNA binding
CHH28_RS06000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHH28_RS06005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHH28_RS06010	COG0051	transcription antitermination factor activity, RNA binding
CHH28_RS06015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHH28_RS06020	COG0088	Forms part of the polypeptide exit tunnel
CHH28_RS06025	COG0089	rRNA binding
CHH28_RS06030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHH28_RS06035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHH28_RS06040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHH28_RS06045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHH28_RS06050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHH28_RS06055	COG0255	Belongs to the universal ribosomal protein uL29 family
CHH28_RS06060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CHH28_RS06065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHH28_RS06070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHH28_RS06075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHH28_RS06080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHH28_RS06085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHH28_RS06090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHH28_RS06095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHH28_RS06100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHH28_RS06105	COG1841	ribosomal large subunit assembly
CHH28_RS06110	COG0200	Binds to the 23S rRNA
CHH28_RS06120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHH28_RS06125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHH28_RS06130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHH28_RS06135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHH28_RS06140	COG0202	RNA polymerase activity
CHH28_RS06145	COG0203	ribosomal protein L17
CHH28_RS06155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHH28_RS06200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHH28_RS06210	COG0517	IMP dehydrogenase activity
CHH28_RS06220	COG0745	RESPONSE REGULATOR receiver
CHH28_RS06240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CHH28_RS06265	COG4181	ATPase activity
CHH28_RS06275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CHH28_RS06280	COG0523	cobalamin synthesis protein
CHH28_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
CHH28_RS06345	COG4206	TonB-dependent receptor
CHH28_RS06355	COG3720	iron ion transport
CHH28_RS06360	COG4558	Periplasmic binding protein
CHH28_RS06365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHH28_RS06370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CHH28_RS06390	COG3275	phosphorelay sensor kinase activity
CHH28_RS06395	COG3279	Response regulator of the LytR AlgR family
CHH28_RS06415	COG1335	isochorismatase
CHH28_RS06450	COG0006	proline dipeptidase activity
CHH28_RS06490	COG4615	Cyclic peptide transporter
CHH28_RS06500	COG1132	(ABC) transporter
CHH28_RS06505	COG4667	esterase of the alpha-beta hydrolase superfamily
CHH28_RS06510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHH28_RS06520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHH28_RS06530	COG2813	Specifically methylates the guanine in position
CHH28_RS06530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHH28_RS06550	COG2897	thiosulfate sulfurtransferase activity
CHH28_RS06555	COG3340	Belongs to the peptidase S51 family
CHH28_RS06570	COG4269	membrane
CHH28_RS06575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CHH28_RS06585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHH28_RS06590	COG0254	rRNA binding
CHH28_RS06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHH28_RS06615	COG1047	Peptidyl-prolyl cis-trans
CHH28_RS06620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CHH28_RS06625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CHH28_RS06630	COG0840	transmembrane signaling receptor activity
CHH28_RS06640	COG0557	exoribonuclease II activity
CHH28_RS06645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHH28_RS06650	COG0427	acetyl-CoA hydrolase
CHH28_RS06655	COG0668	transmembrane transport
CHH28_RS06660	COG0583	DNA-binding transcription factor activity
CHH28_RS06665	COG0439	Biotin carboxylase
CHH28_RS06670	COG5016	pyruvate
CHH28_RS06670	COG0511	ligase activity, forming carbon-carbon bonds
CHH28_RS06685	COG0288	reversible hydration of carbon dioxide
CHH28_RS06740	COG1942	4-Oxalocrotonate Tautomerase
CHH28_RS06755	COG0789	Transcriptional regulator
CHH28_RS06770	COG3540	Alkaline phosphatase
CHH28_RS06775	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS06785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CHH28_RS06790	COG0583	DNA-binding transcription factor activity
CHH28_RS06795	COG1183	phosphatidylcholine synthase activity
CHH28_RS06840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CHH28_RS06850	COG1360	Flagellar Motor Protein
CHH28_RS06855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CHH28_RS06865	COG0142	geranyltranstransferase activity
CHH28_RS06870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CHH28_RS06875	COG2204	response regulator
CHH28_RS06880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHH28_RS06885	COG2738	Putative neutral zinc metallopeptidase
CHH28_RS06900	COG0360	Binds together with S18 to 16S ribosomal RNA
CHH28_RS06905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHH28_RS06920	COG0305	Participates in initiation and elongation during chromosome replication
CHH28_RS06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHH28_RS06950	COG0126	phosphoglycerate kinase activity
CHH28_RS06970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHH28_RS06970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHH28_RS07005	COG0454	-acetyltransferase
CHH28_RS07010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHH28_RS07015	COG2226	methyltransferase
CHH28_RS07025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CHH28_RS07170	COG2199	diguanylate cyclase activity
CHH28_RS07170	COG2200	EAL domain
CHH28_RS07170	COG2202	Pas domain
CHH28_RS07195	COG2818	Glycosylase
CHH28_RS07230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CHH28_RS07240	COG2166	iron-sulfur cluster assembly
CHH28_RS07245	COG0436	Aminotransferase
CHH28_RS07265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CHH28_RS07270	COG4106	trans-aconitate 2-methyltransferase activity
CHH28_RS07290	COG2200	EAL domain
CHH28_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS07340	COG1238	metal cluster binding
CHH28_RS07345	COG0564	pseudouridine synthase activity
CHH28_RS07370	COG2932	Transcriptional regulator
CHH28_RS07390	COG0513	Belongs to the DEAD box helicase family
CHH28_RS07400	COG4977	sequence-specific DNA binding
CHH28_RS07400	COG1917	Cupin 2, conserved barrel domain protein
CHH28_RS07440	COG0318	PFAM AMP-dependent synthetase and ligase
CHH28_RS07445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CHH28_RS07455	COG0307	riboflavin synthase, alpha
CHH28_RS07460	COG0546	phosphoglycolate phosphatase activity
CHH28_RS07470	COG0456	acetyltransferase
CHH28_RS07470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CHH28_RS07500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHH28_RS07500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHH28_RS07520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CHH28_RS07590	COG4181	ATPase activity
CHH28_RS07630	COG0252	asparaginase activity
CHH28_RS07645	COG2824	Alkylphosphonate utilization operon protein PhnA
CHH28_RS07650	COG2329	Antibiotic biosynthesis monooxygenase
CHH28_RS07670	COG4977	sequence-specific DNA binding
CHH28_RS07685	COG0733	neurotransmitter:sodium symporter activity
CHH28_RS07700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CHH28_RS07705	COG2315	Protein conserved in bacteria
CHH28_RS07710	COG1064	alcohol dehydrogenase
CHH28_RS07725	COG0745	RESPONSE REGULATOR receiver
CHH28_RS07750	COG0183	Belongs to the thiolase family
CHH28_RS07775	COG0385	Bile acid
CHH28_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS07810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CHH28_RS07825	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS07830	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS07865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CHH28_RS07870	COG0134	indole-3-glycerol-phosphate synthase activity
CHH28_RS07875	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CHH28_RS07875	COG3210	domain, Protein
CHH28_RS07875	COG3064	Membrane
CHH28_RS07880	COG2831	hemolysin activation secretion protein
CHH28_RS07925	COG2963	transposase activity
CHH28_RS07970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CHH28_RS07975	COG0134	indole-3-glycerol-phosphate synthase activity
CHH28_RS07985	COG0784	Response regulator, receiver
CHH28_RS07985	COG3437	response regulator, receiver
CHH28_RS07995	COG1765	OsmC-like protein
CHH28_RS08000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CHH28_RS08010	COG2813	Specifically methylates the guanine in position
CHH28_RS08020	COG1366	Belongs to the anti-sigma-factor antagonist family
CHH28_RS08030	COG4774	siderophore transport
CHH28_RS08040	COG2205	protein histidine kinase activity
CHH28_RS08040	COG0784	Response regulator, receiver
CHH28_RS08045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CHH28_RS08050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHH28_RS08075	COG0346	lactoylglutathione lyase activity
CHH28_RS08080	COG0678	peroxiredoxin activity
CHH28_RS08080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHH28_RS08090	COG2067	long-chain fatty acid transport protein
CHH28_RS08105	COG1466	dna polymerase III delta subunit
CHH28_RS08110	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CHH28_RS08135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CHH28_RS08170	COG4772	TonB-dependent receptor
CHH28_RS08175	COG2197	response regulator
CHH28_RS08190	COG0583	DNA-binding transcription factor activity
CHH28_RS08215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHH28_RS08250	COG4221	oxidoreductase activity
CHH28_RS08265	COG0415	Belongs to the DNA photolyase family
CHH28_RS08270	COG0789	Transcriptional regulator
CHH28_RS08285	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CHH28_RS08290	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS08295	COG1090	epimerase
CHH28_RS08305	COG0069	glutamate synthase activity
CHH28_RS08340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHH28_RS08360	COG0840	transmembrane signaling receptor activity
CHH28_RS08370	COG1396	sequence-specific DNA binding
CHH28_RS08375	COG3135	benzoate transporter
CHH28_RS08400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS08405	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CHH28_RS08410	COG3710	Transcriptional regulator
CHH28_RS08415	COG4232	protein-disulfide reductase activity
CHH28_RS08430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CHH28_RS08440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHH28_RS08445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CHH28_RS08450	COG0723	plastoquinol--plastocyanin reductase activity
CHH28_RS08455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CHH28_RS08460	COG2857	Cytochrome c1
CHH28_RS08465	COG0625	glutathione transferase activity
CHH28_RS08470	COG2969	positive regulation of protein catabolic process
CHH28_RS08520	COG0730	response to heat
CHH28_RS08525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHH28_RS08545	COG0563	adenylate kinase activity
CHH28_RS08550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHH28_RS08555	COG0154	amidase activity
CHH28_RS08560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHH28_RS08565	COG1077	Cell shape determining protein MreB Mrl
CHH28_RS08570	COG1792	Involved in formation and maintenance of cell shape
CHH28_RS08580	COG0424	maF-like protein
CHH28_RS08595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHH28_RS08600	COG3028	Belongs to the UPF0307 family
CHH28_RS08605	COG2239	Acts as a magnesium transporter
CHH28_RS08615	COG1660	Displays ATPase and GTPase activities
CHH28_RS08635	COG1137	ATPase activity
CHH28_RS08640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CHH28_RS08660	COG1127	ABC transporter
CHH28_RS08665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CHH28_RS08670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CHH28_RS08680	COG5007	Belongs to the BolA IbaG family
CHH28_RS08685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHH28_RS08690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CHH28_RS08695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CHH28_RS08705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHH28_RS08725	COG0504	CTP synthase activity
CHH28_RS08735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CHH28_RS08740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CHH28_RS08745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CHH28_RS08750	COG0585	pseudouridine synthase activity
CHH28_RS08755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CHH28_RS08760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CHH28_RS08785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CHH28_RS08790	COG1546	Belongs to the CinA family
CHH28_RS08795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHH28_RS08810	COG1252	NADH dehydrogenase
CHH28_RS08820	COG0596	Alpha beta hydrolase
CHH28_RS08835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CHH28_RS08845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CHH28_RS08910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CHH28_RS08915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CHH28_RS08920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CHH28_RS08950	COG3932	Exopolysaccharide synthesis, ExoD
CHH28_RS08965	COG1280	lysine exporter protein (LysE YggA)
CHH28_RS08970	COG1522	sequence-specific DNA binding
CHH28_RS08995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHH28_RS09010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CHH28_RS09025	COG0318	PFAM AMP-dependent synthetase and ligase
CHH28_RS09065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CHH28_RS09095	COG1794	racemase activity, acting on amino acids and derivatives
CHH28_RS09100	COG1280	lysine exporter protein (LysE YggA)
CHH28_RS09135	COG4964	Belongs to the GSP D family
CHH28_RS09200	COG3152	Membrane
CHH28_RS09230	COG3397	chitin binding
CHH28_RS09255	COG0583	DNA-binding transcription factor activity
CHH28_RS09260	COG2814	Major facilitator Superfamily
CHH28_RS09280	COG0488	(ABC) transporter
CHH28_RS09305	COG0488	(ABC) transporter
CHH28_RS09315	COG0179	Fumarylacetoacetate (FAA) hydrolase
CHH28_RS09325	COG0629	single-stranded DNA binding
CHH28_RS09330	COG2814	Major facilitator Superfamily
CHH28_RS09335	COG2197	response regulator
CHH28_RS09365	COG0560	Phosphoserine phosphatase
CHH28_RS09365	COG3830	Belongs to the UPF0237 family
CHH28_RS09380	COG1509	lysine 2,3-aminomutase activity
CHH28_RS09385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHH28_RS09390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CHH28_RS09395	COG0688	phosphatidylethanolamine metabolic process
CHH28_RS09410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CHH28_RS09415	COG1360	Flagellar Motor Protein
CHH28_RS09420	COG1162	GTPase activity
CHH28_RS09425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CHH28_RS09445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CHH28_RS09445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CHH28_RS09450	COG0802	atpase or kinase
CHH28_RS09455	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHH28_RS09460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHH28_RS09465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHH28_RS09470	COG1923	regulation of RNA biosynthetic process
CHH28_RS09475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHH28_RS09480	COG0330	HflC and HflK could
CHH28_RS09485	COG0330	HflC and HflK could
CHH28_RS09495	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CHH28_RS09500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CHH28_RS09520	COG0142	geranyltranstransferase activity
CHH28_RS09525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHH28_RS09535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CHH28_RS09540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHH28_RS09545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CHH28_RS09550	COG0268	Binds directly to 16S ribosomal RNA
CHH28_RS09560	COG0196	riboflavin kinase activity
CHH28_RS09565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CHH28_RS09570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CHH28_RS09575	COG1047	Peptidyl-prolyl cis-trans
CHH28_RS09580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CHH28_RS09600	COG4970	Tfp pilus assembly protein FimT
CHH28_RS09630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHH28_RS09630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CHH28_RS09660	COG0028	Belongs to the TPP enzyme family
CHH28_RS09675	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CHH28_RS09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHH28_RS09685	COG5002	protein histidine kinase activity
CHH28_RS09685	COG2198	Histidine kinase
CHH28_RS09685	COG0784	Response regulator, receiver
CHH28_RS09690	COG0151	Belongs to the GarS family
CHH28_RS09695	COG0138	bifunctional purine biosynthesis protein purh
CHH28_RS09705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHH28_RS09720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CHH28_RS09735	COG5001	Diguanylate cyclase
CHH28_RS09735	COG1716	ATPase activity
CHH28_RS09750	COG0237	dephospho-CoA kinase activity
CHH28_RS09780	COG1115	amino acid carrier protein
CHH28_RS09795	COG1940	carbohydrate kinase activity
CHH28_RS09815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHH28_RS09825	COG0579	oxidoreductase
CHH28_RS09840	COG0517	IMP dehydrogenase activity
CHH28_RS09845	COG2072	flavoprotein involved in K transport
CHH28_RS09850	COG3695	enzyme binding
CHH28_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS09865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CHH28_RS09870	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS09875	COG0183	Belongs to the thiolase family
CHH28_RS09880	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHH28_RS09880	COG1024	Enoyl-CoA hydratase
CHH28_RS09890	COG0210	DNA helicase
CHH28_RS09915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CHH28_RS09925	COG0385	Bile acid
CHH28_RS09930	COG4191	Histidine kinase
CHH28_RS09950	COG0023	Translation Initiation Factor
CHH28_RS09960	COG0811	peptide transport
CHH28_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS09985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CHH28_RS09990	COG0583	DNA-binding transcription factor activity
CHH28_RS10000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CHH28_RS10005	COG0047	phosphoribosylformylglycinamidine synthase activity
CHH28_RS10005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHH28_RS10030	COG2154	pterin-4-alpha-carbinolamine dehydratase
CHH28_RS10035	COG0583	DNA-binding transcription factor activity
CHH28_RS10055	COG0625	glutathione transferase activity
CHH28_RS10090	COG0312	modulator of DNA gyrase
CHH28_RS10110	COG2205	protein histidine kinase activity
CHH28_RS10125	COG1944	ATP diphosphatase activity
CHH28_RS10130	COG3604	Transcriptional regulator
CHH28_RS10170	COG0228	four-way junction DNA binding
CHH28_RS10175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHH28_RS10185	COG0335	large ribosomal subunit rRNA binding
CHH28_RS10190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CHH28_RS10215	COG4651	solute:proton antiporter activity
CHH28_RS10215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHH28_RS10230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CHH28_RS10255	COG0492	ferredoxin-NADP+ reductase activity
CHH28_RS10265	COG4783	chaperone-mediated protein folding
CHH28_RS10270	COG0393	Putative heavy-metal-binding
CHH28_RS10275	COG0393	Putative heavy-metal-binding
CHH28_RS10280	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS10300	COG1301	dicarboxylic acid transport
CHH28_RS10310	COG2165	general secretion pathway protein
CHH28_RS10320	COG0583	DNA-binding transcription factor activity
CHH28_RS10355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHH28_RS10360	COG0572	uridine kinase
CHH28_RS10380	COG3226	Transcriptional regulator
CHH28_RS10385	COG0242	peptide deformylase activity
CHH28_RS10400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHH28_RS10400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHH28_RS10405	COG4536	flavin adenine dinucleotide binding
CHH28_RS10415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHH28_RS10420	COG0432	Pfam Uncharacterised protein family UPF0047
CHH28_RS10440	COG0583	DNA-binding transcription factor activity
CHH28_RS10480	COG0513	Belongs to the DEAD box helicase family
CHH28_RS10485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHH28_RS10495	COG1902	pentaerythritol trinitrate reductase activity
CHH28_RS10500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHH28_RS10510	COG0183	Belongs to the thiolase family
CHH28_RS10515	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS10570	COG0644	oxidoreductase
CHH28_RS10605	COG0633	Ferredoxin
CHH28_RS10650	COG1760	l-serine dehydratase
CHH28_RS10660	COG1671	Belongs to the UPF0178 family
CHH28_RS10695	COG2226	methyltransferase
CHH28_RS10705	COG0488	(ABC) transporter
CHH28_RS10730	COG0546	phosphoglycolate phosphatase activity
CHH28_RS10740	COG0589	response to stress
CHH28_RS10745	COG0659	secondary active sulfate transmembrane transporter activity
CHH28_RS10775	COG1132	(ABC) transporter
CHH28_RS10820	COG0697	spore germination
CHH28_RS10825	COG3708	Transcriptional regulator
CHH28_RS10825	COG2207	Transcriptional regulator
CHH28_RS10830	COG4774	siderophore transport
CHH28_RS10830	COG1629	transport
CHH28_RS10840	COG2801	Transposase and inactivated derivatives
CHH28_RS10855	COG2963	transposase activity
CHH28_RS10895	COG0500	methyltransferase
CHH28_RS10905	COG2067	long-chain fatty acid transport protein
CHH28_RS10920	COG0348	domain, Protein
CHH28_RS10935	COG3604	Transcriptional regulator
CHH28_RS11035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS11075	COG1024	Enoyl-CoA hydratase
CHH28_RS11130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHH28_RS11135	COG0481	GTPase activity
CHH28_RS11145	COG0571	ribonuclease III activity
CHH28_RS11150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CHH28_RS11155	COG1381	Involved in DNA repair and RecF pathway recombination
CHH28_RS11165	COG0736	holo-[acyl-carrier-protein] synthase activity
CHH28_RS11170	COG0784	Response regulator, receiver
CHH28_RS11170	COG2205	protein histidine kinase activity
CHH28_RS11170	COG5002	protein histidine kinase activity
CHH28_RS11185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHH28_RS11190	COG3956	TIGRFAM MazG family protein
CHH28_RS11195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CHH28_RS11200	COG0563	adenylate kinase activity
CHH28_RS11210	COG1214	PFAM Peptidase M22, glycoprotease
CHH28_RS11215	COG1968	undecaprenyl-diphosphatase activity
CHH28_RS11220	COG0742	ribosomal rna small subunit methyltransferase
CHH28_RS11225	COG2937	Belongs to the GPAT DAPAT family
CHH28_RS11230	COG1131	(ABC) transporter
CHH28_RS11280	COG0105	UTP biosynthetic process
CHH28_RS11285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CHH28_RS11295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHH28_RS11300	COG0124	histidyl-tRNA synthetase
CHH28_RS11305	COG2976	Protein conserved in bacteria
CHH28_RS11315	COG1160	GTP binding
CHH28_RS11320	COG0840	transmembrane signaling receptor activity
CHH28_RS11330	COG1024	Enoyl-CoA hydratase
CHH28_RS11335	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS11345	COG2832	Protein of unknown function (DUF454)
CHH28_RS11360	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CHH28_RS11370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHH28_RS11375	COG0583	DNA-binding transcription factor activity
CHH28_RS11420	COG0084	hydrolase, TatD family'
CHH28_RS11430	COG0513	Belongs to the DEAD box helicase family
CHH28_RS11435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CHH28_RS11445	COG0052	Belongs to the universal ribosomal protein uS2 family
CHH28_RS11450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CHH28_RS11455	COG0528	UMP kinase activity
CHH28_RS11460	COG0233	cytoplasmic translational termination
CHH28_RS11465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHH28_RS11500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHH28_RS11505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHH28_RS11515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHH28_RS11525	COG2081	HI0933 family
CHH28_RS11545	COG0347	Belongs to the P(II) protein family
CHH28_RS11555	COG2204	response regulator
CHH28_RS11575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CHH28_RS11585	COG1024	Enoyl-CoA hydratase
CHH28_RS11590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CHH28_RS11625	COG0811	peptide transport
CHH28_RS11630	COG0811	peptide transport
CHH28_RS11635	COG0848	biopolymer transport protein
CHH28_RS11640	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CHH28_RS11670	COG2193	ferroxidase activity
CHH28_RS11675	COG0189	ligase activity
CHH28_RS11675	COG4067	protein conserved in archaea
CHH28_RS11685	COG0189	ligase activity
CHH28_RS11690	COG1639	'signal transduction protein
CHH28_RS11695	COG3313	Fe-S protein
CHH28_RS11700	COG1278	Cold shock
CHH28_RS11710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CHH28_RS11715	COG0306	phosphate transporter
CHH28_RS11735	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CHH28_RS11745	COG2264	protein methyltransferase activity
CHH28_RS11755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHH28_RS11760	COG1192	Involved in chromosome partitioning
CHH28_RS11770	COG0084	hydrolase, TatD family'
CHH28_RS11785	COG0741	lytic transglycosylase activity
CHH28_RS11790	COG2264	protein methyltransferase activity
CHH28_RS11815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CHH28_RS11820	COG1074	ATP-dependent DNA helicase activity
CHH28_RS11825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHH28_RS11850	COG0643	Histidine kinase
CHH28_RS11850	COG2198	Histidine kinase
CHH28_RS11860	COG0840	transmembrane signaling receptor activity
CHH28_RS11865	COG0835	chemotaxis
CHH28_RS11870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CHH28_RS11875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CHH28_RS11880	COG2201	protein-glutamate methylesterase activity
CHH28_RS11885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHH28_RS11890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CHH28_RS11895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHH28_RS11905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CHH28_RS11910	COG0072	phenylalanine-tRNA ligase activity
CHH28_RS11960	COG0318	PFAM AMP-dependent synthetase and ligase
CHH28_RS11965	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS11970	COG1960	acyl-CoA dehydrogenase activity
CHH28_RS11980	COG3022	response to hydroperoxide
CHH28_RS11995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHH28_RS12005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHH28_RS12010	COG1805	sodium ion transport
CHH28_RS12025	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHH28_RS12030	COG2871	sodium ion transport
CHH28_RS12050	COG3268	Saccharopine dehydrogenase
CHH28_RS12070	COG0545	Peptidyl-prolyl cis-trans isomerase
CHH28_RS12090	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHH28_RS12130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHH28_RS12135	COG0302	gtp cyclohydrolase
CHH28_RS12145	COG3706	GGDEF domain
CHH28_RS12175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHH28_RS12190	COG0271	Belongs to the BolA IbaG family
CHH28_RS12200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CHH28_RS12230	COG0714	Associated with various cellular activities
CHH28_RS12245	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CHH28_RS12265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CHH28_RS12280	COG0175	sulfate reduction
CHH28_RS12285	COG2945	thiolester hydrolase activity
CHH28_RS12290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CHH28_RS12305	COG1012	belongs to the aldehyde dehydrogenase family
CHH28_RS12335	COG0300	oxidoreductase activity
CHH28_RS12345	COG1477	protein flavinylation
CHH28_RS12390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CHH28_RS12395	COG0343	queuine tRNA-ribosyltransferase activity
CHH28_RS12400	COG1862	Preprotein translocase
CHH28_RS12420	COG2096	Adenosyltransferase
CHH28_RS12445	COG1666	GTP binding
CHH28_RS12450	COG2211	Major facilitator Superfamily
CHH28_RS12455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CHH28_RS12485	COG5002	protein histidine kinase activity
CHH28_RS12485	COG2198	Histidine kinase
CHH28_RS12485	COG0784	Response regulator, receiver
CHH28_RS12500	COG2925	Exonuclease
CHH28_RS12510	COG1162	GTPase activity
CHH28_RS12525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHH28_RS12530	COG3630	sodium ion export across plasma membrane
CHH28_RS12535	COG0511	ligase activity, forming carbon-carbon bonds
CHH28_RS12535	COG5016	pyruvate
CHH28_RS12540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CHH28_RS12545	COG3842	ATPase activity
CHH28_RS12550	COG1178	ABC-type Fe3 transport system permease component
CHH28_RS12555	COG1840	ABC-type Fe3 transport system, periplasmic component
CHH28_RS12560	COG0632	four-way junction helicase activity
CHH28_RS12565	COG2255	four-way junction helicase activity
CHH28_RS12570	COG0824	Thioesterase
CHH28_RS12585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CHH28_RS12590	COG0823	Involved in the tonB-independent uptake of proteins
CHH28_RS12595	COG2885	chlorophyll binding
CHH28_RS12615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CHH28_RS12620	COG4783	chaperone-mediated protein folding
CHH28_RS12625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHH28_RS12625	COG0425	Belongs to the sulfur carrier protein TusA family
CHH28_RS12635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHH28_RS12645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHH28_RS12650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CHH28_RS12665	COG0545	Peptidyl-prolyl cis-trans isomerase
CHH28_RS12695	COG0363	glucosamine-6-phosphate deaminase activity
CHH28_RS12705	COG0800	Aldolase
CHH28_RS12720	COG1215	transferase activity, transferring glycosyl groups
CHH28_RS12735	COG1605	Chorismate mutase
CHH28_RS12735	COG0077	Prephenate dehydratase
CHH28_RS12755	COG3437	response regulator, receiver
CHH28_RS12775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CHH28_RS12790	COG2022	thiamine diphosphate biosynthetic process
CHH28_RS12800	COG0326	Molecular chaperone. Has ATPase activity
CHH28_RS12820	COG1115	amino acid carrier protein
CHH28_RS12825	COG1132	(ABC) transporter
CHH28_RS12830	COG1132	(ABC) transporter
CHH28_RS12860	COG4977	sequence-specific DNA binding
CHH28_RS12885	COG2205	protein histidine kinase activity
CHH28_RS12925	COG2207	Transcriptional regulator
CHH28_RS12930	COG1979	alcohol dehydrogenase
CHH28_RS12945	COG0587	DNA-directed DNA polymerase activity
CHH28_RS12990	COG3291	Pkd domain containing protein
CHH28_RS13020	COG1012	belongs to the aldehyde dehydrogenase family
CHH28_RS13025	COG0006	proline dipeptidase activity
CHH28_RS13030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CHH28_RS13040	COG1473	amidohydrolase
CHH28_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHH28_RS13050	COG3850	Histidine kinase
CHH28_RS13050	COG3437	response regulator, receiver
CHH28_RS13050	COG2205	protein histidine kinase activity
CHH28_RS13050	COG4999	Histidine kinase
CHH28_RS13060	COG5002	protein histidine kinase activity
CHH28_RS13060	COG0784	Response regulator, receiver
CHH28_RS13060	COG2205	protein histidine kinase activity
CHH28_RS13065	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS13075	COG3437	response regulator, receiver
CHH28_RS13080	COG3850	Histidine kinase
CHH28_RS13080	COG2205	protein histidine kinase activity
CHH28_RS13080	COG3437	response regulator, receiver
CHH28_RS13080	COG4999	Histidine kinase
CHH28_RS13120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CHH28_RS13130	COG1573	uracil-dna glycosylase
CHH28_RS13135	COG0776	regulation of translation
CHH28_RS13140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHH28_RS13145	COG1565	acr, cog1565
CHH28_RS13145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CHH28_RS13155	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CHH28_RS13160	COG1845	cytochrome c oxidase, subunit III
CHH28_RS13185	COG0109	protoheme IX farnesyltransferase activity
CHH28_RS13190	COG0204	Acyl-transferase
CHH28_RS13210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHH28_RS13220	COG0436	Aminotransferase
CHH28_RS13225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHH28_RS13230	COG0386	Belongs to the glutathione peroxidase family
CHH28_RS13235	COG1846	Transcriptional regulator
CHH28_RS13240	COG3850	Histidine kinase
CHH28_RS13240	COG4999	Histidine kinase
CHH28_RS13240	COG3437	response regulator, receiver
CHH28_RS13240	COG2205	protein histidine kinase activity
CHH28_RS13285	COG1131	(ABC) transporter
CHH28_RS13290	COG0842	Transport permease protein
CHH28_RS13295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CHH28_RS13295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CHH28_RS13305	COG0778	Nitroreductase
CHH28_RS13350	COG0732	type I restriction modification DNA specificity domain
CHH28_RS13390	COG1253	flavin adenine dinucleotide binding
CHH28_RS13400	COG2304	oxidoreductase activity
CHH28_RS13420	COG0714	Associated with various cellular activities
CHH28_RS13450	COG5002	protein histidine kinase activity
CHH28_RS13465	COG0167	dihydroorotate dehydrogenase activity
CHH28_RS13470	COG3130	regulation of translation
CHH28_RS13480	COG0004	ammonium transporteR
CHH28_RS13525	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CHH28_RS13525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHH28_RS13545	COG1196	nuclear chromosome segregation
CHH28_RS13550	COG3115	cell septum assembly
CHH28_RS13555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CHH28_RS13565	COG5001	Diguanylate cyclase
CHH28_RS13565	COG5002	protein histidine kinase activity
CHH28_RS13565	COG3447	MASE1 domain protein
CHH28_RS13575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHH28_RS13600	COG1946	Acyl-CoA thioesterase
CHH28_RS13610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHH28_RS13620	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS13635	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS13640	COG0110	maltose O-acetyltransferase activity
CHH28_RS13675	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS13680	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS13690	COG2204	response regulator
CHH28_RS13700	COG0745	RESPONSE REGULATOR receiver
CHH28_RS13730	COG0714	Associated with various cellular activities
CHH28_RS13750	COG3118	belongs to the thioredoxin family
CHH28_RS13755	COG0667	Aldo Keto reductase
CHH28_RS13765	COG3101	peptidyl-lysine hydroxylation
CHH28_RS13795	COG5265	(ABC) transporter
CHH28_RS13830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CHH28_RS13840	COG2205	protein histidine kinase activity
CHH28_RS13840	COG0784	Response regulator, receiver
CHH28_RS13845	COG1067	ATP-dependent peptidase activity
CHH28_RS13865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHH28_RS13870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CHH28_RS13875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHH28_RS13885	COG3100	YcgL domain-containing protein
CHH28_RS13890	COG2983	Belongs to the UPF0260 family
CHH28_RS13910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHH28_RS13920	COG2030	dehydratase
CHH28_RS13930	COG0318	PFAM AMP-dependent synthetase and ligase
CHH28_RS13935	COG1643	Atp-dependent helicase
CHH28_RS13945	COG3220	belongs to the UPF0276 family
CHH28_RS13955	COG2853	Lipoprotein
CHH28_RS13970	COG1388	LysM domain
CHH28_RS13970	COG0741	lytic transglycosylase activity
CHH28_RS13980	COG0328	RNA-DNA hybrid ribonuclease activity
CHH28_RS13985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHH28_RS14000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHH28_RS14020	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHH28_RS14025	COG0740	serine-type endopeptidase activity
CHH28_RS14030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHH28_RS14035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CHH28_RS14050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHH28_RS14060	COG0616	signal peptide processing
CHH28_RS14065	COG0604	alcohol dehydrogenase
CHH28_RS14090	COG0584	glycerophosphoryl diester phosphodiesterase
CHH28_RS14095	COG0534	Mate efflux family protein
CHH28_RS14105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CHH28_RS14105	COG0316	Belongs to the HesB IscA family
CHH28_RS14115	COG2204	response regulator
CHH28_RS14125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHH28_RS14135	COG2062	phosphohistidine phosphatase, SixA
CHH28_RS14145	COG0596	Alpha beta hydrolase
CHH28_RS14145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CHH28_RS14165	COG0826	peptidase U32
CHH28_RS14185	COG1739	Uncharacterized protein family UPF0029
CHH28_RS14190	COG2813	Specifically methylates the guanine in position
CHH28_RS14205	COG0640	Transcriptional regulator
CHH28_RS14210	COG1477	protein flavinylation
CHH28_RS14220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHH28_RS14235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CHH28_RS14250	COG2915	High frequency lysogenization protein hflD homolog
CHH28_RS14255	COG0482	sulfurtransferase activity
CHH28_RS14275	COG1278	Cold shock
CHH28_RS14280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CHH28_RS14285	COG0542	response to heat
CHH28_RS14290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHH28_RS14295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CHH28_RS14300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CHH28_RS14310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CHH28_RS14315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHH28_RS14320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHH28_RS14325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CHH28_RS14335	COG0840	transmembrane signaling receptor activity
CHH28_RS14355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CHH28_RS14365	COG0123	including yeast histone deacetylase and acetoin utilization protein
CHH28_RS14370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CHH28_RS14370	COG1042	CoA-binding domain protein
CHH28_RS14370	COG0045	succinate-CoA ligase (ADP-forming) activity
CHH28_RS14405	COG5001	Diguanylate cyclase
CHH28_RS14405	COG5002	protein histidine kinase activity
CHH28_RS14410	COG3300	MHYT domain
CHH28_RS14410	COG5001	Diguanylate cyclase
CHH28_RS14415	COG4191	Histidine kinase
CHH28_RS14415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS14440	COG2066	Belongs to the glutaminase family
CHH28_RS14490	COG2165	general secretion pathway protein
CHH28_RS14540	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHH28_RS14540	COG1902	pentaerythritol trinitrate reductase activity
CHH28_RS14550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHH28_RS14555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHH28_RS14705	COG3152	Membrane
CHH28_RS14735	COG1131	(ABC) transporter
CHH28_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS14760	COG0301	tRNA thio-modification
CHH28_RS14760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHH28_RS14770	COG0708	Exodeoxyribonuclease III
CHH28_RS14810	COG0848	biopolymer transport protein
CHH28_RS14815	COG0811	peptide transport
CHH28_RS14820	COG0811	peptide transport
CHH28_RS14855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHH28_RS14860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHH28_RS14865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHH28_RS14870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHH28_RS14875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHH28_RS14890	COG0416	fatty acid biosynthetic process
CHH28_RS14895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHH28_RS14910	COG0546	phosphoglycolate phosphatase activity
CHH28_RS14920	COG1530	ribonuclease E activity
CHH28_RS14925	COG2828	Protein conserved in bacteria
CHH28_RS14935	COG0372	Belongs to the citrate synthase family
CHH28_RS14940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CHH28_RS14945	COG2186	Transcriptional regulator
CHH28_RS14970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CHH28_RS15005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CHH28_RS15010	COG0560	Phosphoserine phosphatase
CHH28_RS15025	COG0730	response to heat
CHH28_RS15055	COG1286	toxin biosynthetic process
CHH28_RS15065	COG0285	dihydrofolate synthase activity
CHH28_RS15070	COG0159	tryptophan synthase activity
CHH28_RS15075	COG0133	tryptophan synthase activity
CHH28_RS15080	COG0135	phosphoribosylanthranilate isomerase activity
CHH28_RS15095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHH28_RS15100	COG0473	3-isopropylmalate dehydrogenase activity
CHH28_RS15105	COG0066	3-isopropylmalate dehydratase activity
CHH28_RS15110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CHH28_RS15120	COG0589	response to stress
CHH28_RS15135	COG3001	Fructosamine kinase
CHH28_RS15155	COG0795	lipopolysaccharide-transporting ATPase activity
CHH28_RS15160	COG0795	lipopolysaccharide-transporting ATPase activity
CHH28_RS15165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHH28_RS15175	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHH28_RS15185	COG0686	Belongs to the AlaDH PNT family
CHH28_RS15225	COG0442	prolyl-tRNA aminoacylation
CHH28_RS15235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CHH28_RS15275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CHH28_RS15290	COG0277	FAD linked oxidase domain protein
CHH28_RS15305	COG0247	lactate metabolic process
CHH28_RS15310	COG2186	Transcriptional regulator
CHH28_RS15350	COG1196	nuclear chromosome segregation
CHH28_RS15350	COG0741	lytic transglycosylase activity
CHH28_RS15350	COG0739	heme binding
CHH28_RS15355	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CHH28_RS15360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CHH28_RS15360	COG0519	Catalyzes the synthesis of GMP from XMP
CHH28_RS15385	COG1570	exodeoxyribonuclease VII activity
CHH28_RS15405	COG0215	cysteine-tRNA ligase activity
CHH28_RS15410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHH28_RS15415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHH28_RS15420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHH28_RS15425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHH28_RS15430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CHH28_RS15435	COG2835	tetraacyldisaccharide 4'-kinase activity
CHH28_RS15440	COG1663	tetraacyldisaccharide 4'-kinase activity
CHH28_RS15445	COG1132	(ABC) transporter
CHH28_RS15450	COG0848	biopolymer transport protein
CHH28_RS15455	COG0811	peptide transport
CHH28_RS15460	COG2333	competence protein COMEC
CHH28_RS15460	COG0658	competence protein
CHH28_RS15475	COG4591	ABC-type transport system involved in lipoprotein release permease component
CHH28_RS15480	COG2957	Belongs to the agmatine deiminase family
CHH28_RS15485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CHH28_RS15500	COG1199	ATP-dependent helicase activity
CHH28_RS15510	COG3409	Peptidoglycan-binding domain 1 protein
CHH28_RS15510	COG3267	Type II secretory pathway component ExeA
CHH28_RS15525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CHH28_RS15560	COG2850	peptidyl-arginine hydroxylation
CHH28_RS15575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CHH28_RS15585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CHH28_RS15600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHH28_RS15605	COG0840	transmembrane signaling receptor activity
CHH28_RS15615	COG0045	succinate-CoA ligase (ADP-forming) activity
CHH28_RS15635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CHH28_RS15640	COG1053	succinate dehydrogenase
CHH28_RS15645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CHH28_RS15660	COG2084	Dehydrogenase
CHH28_RS15675	COG0784	Response regulator, receiver
CHH28_RS15675	COG0835	chemotaxis
CHH28_RS15680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CHH28_RS15685	COG1070	Carbohydrate kinase
CHH28_RS15690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CHH28_RS15715	COG0859	PFAM glycosyl transferase family 9
CHH28_RS15725	COG0463	Glycosyl transferase, family 2
CHH28_RS15730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CHH28_RS15750	COG0439	Biotin carboxylase
CHH28_RS15755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS15760	COG4597	amino acid ABC transporter
CHH28_RS15765	COG0765	amino acid transport
CHH28_RS15770	COG1126	abc transporter atp-binding protein
CHH28_RS15780	COG0840	transmembrane signaling receptor activity
CHH28_RS15785	COG2205	protein histidine kinase activity
CHH28_RS15785	COG0784	Response regulator, receiver
CHH28_RS15790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS15795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHH28_RS15805	COG2807	transmembrane transport
CHH28_RS15860	COG2205	protein histidine kinase activity
CHH28_RS15870	COG1902	pentaerythritol trinitrate reductase activity
CHH28_RS15870	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHH28_RS15875	COG0489	protein tyrosine kinase activity
CHH28_RS15885	COG1073	alpha beta
CHH28_RS15910	COG0789	Transcriptional regulator
CHH28_RS15915	COG5001	Diguanylate cyclase
CHH28_RS15915	COG2203	Gaf domain
CHH28_RS15915	COG3706	GGDEF domain
CHH28_RS15915	COG4251	negative regulation of phosphorylation
CHH28_RS15920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CHH28_RS15975	COG0564	pseudouridine synthase activity
CHH28_RS15980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHH28_RS15995	COG4191	Histidine kinase
CHH28_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS16000	COG3384	dioxygenase
CHH28_RS16005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CHH28_RS16025	COG2169	Transcriptional regulator
CHH28_RS16025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHH28_RS16030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CHH28_RS16035	COG4106	trans-aconitate 2-methyltransferase activity
CHH28_RS16040	COG1322	Protein conserved in bacteria
CHH28_RS16060	COG0546	phosphoglycolate phosphatase activity
CHH28_RS16065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CHH28_RS16085	COG3314	Sporulation integral membrane protein YlbJ
CHH28_RS16090	COG0183	Belongs to the thiolase family
CHH28_RS16095	COG1250	3-hydroxyacyl-CoA dehydrogenase
CHH28_RS16095	COG1024	Enoyl-CoA hydratase
CHH28_RS16110	COG0814	amino acid
CHH28_RS16140	COG0583	DNA-binding transcription factor activity
CHH28_RS16145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS16165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CHH28_RS16170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHH28_RS16175	COG2226	methyltransferase
CHH28_RS16195	COG0525	valine-tRNA ligase activity
CHH28_RS16205	COG0525	valine-tRNA ligase activity
CHH28_RS16220	COG0583	DNA-binding transcription factor activity
CHH28_RS16260	COG1054	Belongs to the UPF0176 family
CHH28_RS16265	COG4657	Part of a membrane complex involved in electron transport
CHH28_RS16270	COG2878	Part of a membrane complex involved in electron transport
CHH28_RS16275	COG4656	Part of a membrane complex involved in electron transport
CHH28_RS16280	COG4658	electron transport chain
CHH28_RS16285	COG4659	FMN binding
CHH28_RS16290	COG4660	Part of a membrane complex involved in electron transport
CHH28_RS16295	COG1741	Belongs to the pirin family
CHH28_RS16315	COG5001	Diguanylate cyclase
CHH28_RS16315	COG3706	GGDEF domain
CHH28_RS16315	COG4251	negative regulation of phosphorylation
CHH28_RS16315	COG2203	Gaf domain
CHH28_RS16325	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
CHH28_RS16375	COG1115	amino acid carrier protein
CHH28_RS16385	COG0252	asparaginase activity
CHH28_RS16450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHH28_RS16490	COG1917	Cupin 2, conserved barrel domain protein
CHH28_RS16490	COG2207	Transcriptional regulator
CHH28_RS16505	COG0583	DNA-binding transcription factor activity
CHH28_RS16510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CHH28_RS16520	COG2252	PERMEase
CHH28_RS16525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHH28_RS16540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CHH28_RS16560	COG0719	Fe-S assembly protein
CHH28_RS16565	COG0396	ATPase activity
CHH28_RS16570	COG0719	Fe-S assembly protein
CHH28_RS16575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHH28_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS16610	COG1643	Atp-dependent helicase
CHH28_RS16645	COG1297	OPT oligopeptide transporter protein
CHH28_RS16655	COG0583	DNA-binding transcription factor activity
CHH28_RS16665	COG2095	MarC family integral membrane protein
CHH28_RS16680	COG0789	Transcriptional regulator
CHH28_RS16685	COG0384	phenazine biosynthesis protein PhzF
CHH28_RS16730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CHH28_RS16735	COG2207	Transcriptional regulator
CHH28_RS16740	COG4206	TonB-dependent receptor
CHH28_RS16755	COG0601	transmembrane transport
CHH28_RS16760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHH28_RS16775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CHH28_RS16780	COG0509	glycine decarboxylation via glycine cleavage system
CHH28_RS16785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHH28_RS16785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CHH28_RS16795	COG2860	membrane
CHH28_RS16810	COG2205	protein histidine kinase activity
CHH28_RS16810	COG0784	Response regulator, receiver
CHH28_RS16810	COG2198	Histidine kinase
CHH28_RS16830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHH28_RS16835	COG1138	Cytochrome C-type biogenesis protein
CHH28_RS16840	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CHH28_RS16855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CHH28_RS16860	COG4133	protoheme IX ABC transporter activity
CHH28_RS16870	COG2257	FlhB HrpN YscU SpaS Family
CHH28_RS16930	COG0204	Acyl-transferase
CHH28_RS16935	COG3706	GGDEF domain
CHH28_RS16935	COG2203	Gaf domain
CHH28_RS16935	COG4251	negative regulation of phosphorylation
CHH28_RS16935	COG5001	Diguanylate cyclase
CHH28_RS16940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CHH28_RS16985	COG1472	Belongs to the glycosyl hydrolase 3 family
CHH28_RS17000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHH28_RS17010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CHH28_RS17015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CHH28_RS17020	COG3122	Protein conserved in bacteria
CHH28_RS17050	COG0840	transmembrane signaling receptor activity
CHH28_RS17095	COG3278	Belongs to the heme-copper respiratory oxidase family
CHH28_RS17110	COG2010	Cytochrome c
CHH28_RS17125	COG2217	Heavy metal translocating P-type atpase
CHH28_RS17140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CHH28_RS17150	COG0037	tRNA processing
CHH28_RS17170	COG0484	heat shock protein binding
CHH28_RS17180	COG4335	DNA alkylation repair
CHH28_RS17235	COG0745	RESPONSE REGULATOR receiver
CHH28_RS17245	COG1025	Belongs to the peptidase M16 family
CHH28_RS17250	COG0300	oxidoreductase activity
CHH28_RS17275	COG1793	dna ligase
CHH28_RS17285	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CHH28_RS17290	COG0798	PFAM Bile acid sodium symporter
CHH28_RS17295	COG0431	NADPH-dependent FMN reductase
CHH28_RS17305	COG0640	Transcriptional regulator
CHH28_RS17435	COG4128	Pfam Zonular occludens toxin
CHH28_RS17455	COG0582	viral genome integration into host DNA
CHH28_RS17490	COG2226	methyltransferase
CHH28_RS17505	COG0436	Aminotransferase
CHH28_RS17510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHH28_RS17525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CHH28_RS17535	COG0717	Belongs to the dCTP deaminase family
CHH28_RS17580	COG1295	ribonuclease BN
CHH28_RS17585	COG1393	Belongs to the ArsC family
CHH28_RS17615	COG0284	orotidine-5'-phosphate decarboxylase activity
CHH28_RS17620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CHH28_RS17630	COG0776	regulation of translation
CHH28_RS17640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CHH28_RS17645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHH28_RS17650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CHH28_RS17660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CHH28_RS17670	COG0402	S-adenosylhomocysteine deaminase activity
CHH28_RS17680	COG0546	phosphoglycolate phosphatase activity
CHH28_RS17685	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS17690	COG3706	GGDEF domain
CHH28_RS17700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CHH28_RS17715	COG0009	L-threonylcarbamoyladenylate synthase
CHH28_RS17720	COG0613	PHP domain protein
CHH28_RS17725	COG2350	Protein conserved in bacteria
CHH28_RS17730	COG4991	sh3 domain protein
CHH28_RS17750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHH28_RS17750	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CHH28_RS17770	COG3243	poly(R)-hydroxyalkanoic acid synthase
CHH28_RS17790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHH28_RS17810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CHH28_RS17830	COG0583	DNA-binding transcription factor activity
CHH28_RS17865	COG4651	solute:proton antiporter activity
CHH28_RS17865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHH28_RS17870	COG0589	response to stress
CHH28_RS17885	COG0697	spore germination
CHH28_RS17895	COG3107	peptidoglycan biosynthetic process
CHH28_RS17900	COG0792	nuclease activity
CHH28_RS17905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CHH28_RS17910	COG0425	Belongs to the sulfur carrier protein TusA family
CHH28_RS17915	COG2814	Major facilitator Superfamily
CHH28_RS17935	COG0400	carboxylic ester hydrolase activity
CHH28_RS17940	COG1393	Belongs to the ArsC family
CHH28_RS17945	COG2171	N-acyltransferase activity
CHH28_RS17950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHH28_RS17965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHH28_RS18000	COG1846	Transcriptional regulator
CHH28_RS18010	COG0583	DNA-binding transcription factor activity
CHH28_RS18030	COG0137	argininosuccinate synthase activity
CHH28_RS18035	COG3047	cAMP biosynthetic process
CHH28_RS18035	COG2885	chlorophyll binding
CHH28_RS18045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHH28_RS18050	COG3112	Uncharacterised protein family (UPF0231)
CHH28_RS18070	COG0676	glucose-6-phosphate 1-epimerase activity
CHH28_RS18125	COG0488	(ABC) transporter
CHH28_RS18135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS18245	COG1404	Belongs to the peptidase S8 family
CHH28_RS18255	COG1404	Belongs to the peptidase S8 family
CHH28_RS18260	COG3291	Pkd domain containing protein
CHH28_RS18290	COG0308	aminopeptidase N
CHH28_RS18300	COG3139	Protein of unknown function (DUF1315)
CHH28_RS18310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHH28_RS18315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHH28_RS18340	COG1596	polysaccharide export
CHH28_RS18340	COG1555	photosystem II stabilization
CHH28_RS18375	COG2207	Transcriptional regulator
CHH28_RS18380	COG0494	nUDIX hydrolase
CHH28_RS18395	COG0681	Belongs to the peptidase S26 family
CHH28_RS18425	COG0513	Belongs to the DEAD box helicase family
CHH28_RS18430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS18430	COG4191	Histidine kinase
CHH28_RS18435	COG3123	guanosine phosphorylase activity
CHH28_RS18450	COG3530	Putative quorum-sensing-regulated virulence factor
CHH28_RS18455	COG0519	Catalyzes the synthesis of GMP from XMP
CHH28_RS18455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CHH28_RS18470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CHH28_RS18475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHH28_RS18485	COG0488	(ABC) transporter
CHH28_RS18525	COG0037	tRNA processing
CHH28_RS18530	COG0587	DNA-directed DNA polymerase activity
CHH28_RS18555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CHH28_RS18560	COG0602	queuosine metabolic process
CHH28_RS18565	COG0604	alcohol dehydrogenase
CHH28_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
CHH28_RS18565	COG3321	synthase
CHH28_RS18570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHH28_RS18580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CHH28_RS18585	COG0583	DNA-binding transcription factor activity
CHH28_RS18590	COG2205	protein histidine kinase activity
CHH28_RS18595	COG0745	RESPONSE REGULATOR receiver
CHH28_RS18600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHH28_RS18610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CHH28_RS18620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CHH28_RS18645	COG0835	chemotaxis
CHH28_RS18660	COG1192	Involved in chromosome partitioning
CHH28_RS18670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CHH28_RS18675	COG2201	protein-glutamate methylesterase activity
CHH28_RS18680	COG0643	Histidine kinase
CHH28_RS18680	COG2198	Histidine kinase
CHH28_RS18680	COG0784	Response regulator, receiver
CHH28_RS18685	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CHH28_RS18725	COG1987	bacterial-type flagellum assembly
CHH28_RS18775	COG2201	protein-glutamate methylesterase activity
CHH28_RS18780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CHH28_RS18790	COG0840	transmembrane signaling receptor activity
CHH28_RS18800	COG2198	Histidine kinase
CHH28_RS18800	COG0643	Histidine kinase
CHH28_RS18805	COG0745	RESPONSE REGULATOR receiver
CHH28_RS18840	COG1677	Flagellar hook-basal body complex protein FliE
CHH28_RS18875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHH28_RS18880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHH28_RS18885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CHH28_RS18915	COG1256	bacterial-type flagellum assembly
CHH28_RS18930	COG1706	bacterial-type flagellum-dependent cell motility
CHH28_RS18935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CHH28_RS18940	COG4786	Flagellar basal body rod
CHH28_RS18945	COG4787	bacterial-type flagellum-dependent cell motility
CHH28_RS18955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CHH28_RS18965	COG1815	bacterial-type flagellum-dependent cell motility
CHH28_RS18970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CHH28_RS18975	COG0784	Response regulator, receiver
CHH28_RS18975	COG0835	chemotaxis
CHH28_RS19010	COG0604	alcohol dehydrogenase
CHH28_RS19060	COG1842	Phage shock protein A
CHH28_RS19070	COG4191	Histidine kinase
CHH28_RS19070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHH28_RS19080	COG1846	Transcriptional regulator
CHH28_RS19085	COG1764	response to oxidative stress
CHH28_RS19120	COG0840	transmembrane signaling receptor activity
CHH28_RS19130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHH28_RS19155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHH28_RS19160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHH28_RS19160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHH28_RS19175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CHH28_RS19185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CHH28_RS19215	COG1733	regulation of RNA biosynthetic process
CHH28_RS19230	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHH28_RS19240	COG1024	Enoyl-CoA hydratase
CHH28_RS19245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CHH28_RS19250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CHH28_RS19255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CHH28_RS19260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CHH28_RS19265	COG4942	peptidase
CHH28_RS19270	COG0793	Belongs to the peptidase S41A family
CHH28_RS19275	COG2861	carbohydrate metabolic process
CHH28_RS19290	COG3148	PFAM DTW domain containing protein
CHH28_RS19295	COG0647	UMP catabolic process
CHH28_RS19300	COG1858	cytochrome C peroxidase
CHH28_RS19325	COG0417	DNA replication proofreading
CHH28_RS19345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CHH28_RS19355	COG1489	DNA binding
CHH28_RS19360	COG0436	Aminotransferase
CHH28_RS19370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHH28_RS19375	COG3852	Histidine kinase
CHH28_RS19385	COG0617	tRNA 3'-terminal CCA addition
CHH28_RS19390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHH28_RS19400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHH28_RS19410	COG1280	lysine exporter protein (LysE YggA)
CHH28_RS19430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CHH28_RS19435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CHH28_RS19440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CHH28_RS19445	COG0166	Belongs to the GPI family
CHH28_RS19450	COG0840	transmembrane signaling receptor activity
CHH28_RS19455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CHH28_RS19470	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CHH28_RS19485	COG2921	Belongs to the UPF0250 family
CHH28_RS19490	COG1686	Belongs to the peptidase S11 family
CHH28_RS19505	COG3012	SEC-C Motif Domain Protein
CHH28_RS19520	COG0586	Pfam SNARE associated Golgi protein
CHH28_RS19540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHH28_RS19545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CHH28_RS19555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHH28_RS19560	COG0768	penicillin binding
CHH28_RS19565	COG0772	Belongs to the SEDS family
CHH28_RS19570	COG2951	lytic endotransglycosylase activity
CHH28_RS19575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CHH28_RS19600	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS19670	COG0438	transferase activity, transferring glycosyl groups
CHH28_RS19680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CHH28_RS19690	COG0850	regulation of cytokinetic process
CHH28_RS19720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CHH28_RS19740	COG1490	D-aminoacyl-tRNA deacylase activity
CHH28_RS19750	COG3852	Histidine kinase
CHH28_RS19755	COG2204	response regulator