locus-tag	class	description
KFF03_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFF03_RS00010	COG0592	DNA-directed DNA polymerase activity
KFF03_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFF03_RS00035	COG2056	Na+-H+ antiporter family
KFF03_RS00040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KFF03_RS00045	COG5380	lipid catabolic process
KFF03_RS00090	COG0583	DNA-binding transcription factor activity
KFF03_RS00100	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFF03_RS00120	COG0165	Argininosuccinate lyase
KFF03_RS00125	COG3275	phosphorelay sensor kinase activity
KFF03_RS00135	COG2233	PERMEase
KFF03_RS00145	COG0217	transcriptional regulatory protein
KFF03_RS00155	COG3609	addiction module antidote protein, CC2985 family
KFF03_RS00160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KFF03_RS00165	COG0339	signal peptide processing
KFF03_RS00195	COG2353	YceI-like domain
KFF03_RS00200	COG3038	cytochrome b561
KFF03_RS00215	COG0534	Mate efflux family protein
KFF03_RS00225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFF03_RS00230	COG1121	(ABC) transporter
KFF03_RS00235	COG0735	belongs to the Fur family
KFF03_RS00240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KFF03_RS00245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFF03_RS00250	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KFF03_RS00260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFF03_RS00275	COG3300	MHYT domain
KFF03_RS00275	COG5001	Diguanylate cyclase
KFF03_RS00295	COG0501	Belongs to the peptidase M48B family
KFF03_RS00315	COG4774	siderophore transport
KFF03_RS00370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFF03_RS00370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KFF03_RS00385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFF03_RS00425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFF03_RS00435	COG0140	phosphoribosyl-ATP diphosphatase activity
KFF03_RS00440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFF03_RS00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KFF03_RS00465	COG2226	methyltransferase
KFF03_RS00480	COG0494	nUDIX hydrolase
KFF03_RS00490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFF03_RS00495	COG3150	esterase
KFF03_RS00500	COG4251	negative regulation of phosphorylation
KFF03_RS00500	COG5001	Diguanylate cyclase
KFF03_RS00500	COG3706	GGDEF domain
KFF03_RS00500	COG2203	Gaf domain
KFF03_RS00525	COG2267	carboxylic ester hydrolase activity
KFF03_RS00530	COG0742	ribosomal rna small subunit methyltransferase
KFF03_RS00540	COG0552	protein localization to endoplasmic reticulum
KFF03_RS00545	COG2884	Cell division ATP-binding protein ftsE
KFF03_RS00550	COG2177	Part of the ABC transporter FtsEX involved in
KFF03_RS00565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF03_RS00570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KFF03_RS00570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KFF03_RS00575	COG1519	Transferase
KFF03_RS00660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFF03_RS00665	COG0204	Acyl-transferase
KFF03_RS00675	COG0583	DNA-binding transcription factor activity
KFF03_RS00695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFF03_RS00700	COG2813	Specifically methylates the guanine in position
KFF03_RS00700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFF03_RS00710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFF03_RS00720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFF03_RS00730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFF03_RS00750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KFF03_RS00750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KFF03_RS00755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KFF03_RS00780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFF03_RS00800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFF03_RS00805	COG0081	regulation of translation
KFF03_RS00810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFF03_RS00815	COG0222	ribosome binding
KFF03_RS00820	COG0085	RNA polymerase activity
KFF03_RS00830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFF03_RS00835	COG0049	tRNA binding
KFF03_RS00840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFF03_RS00845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFF03_RS00850	COG0051	transcription antitermination factor activity, RNA binding
KFF03_RS00855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFF03_RS00860	COG0088	Forms part of the polypeptide exit tunnel
KFF03_RS00865	COG0089	rRNA binding
KFF03_RS00870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFF03_RS00875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFF03_RS00880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFF03_RS00885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFF03_RS00890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFF03_RS00895	COG0255	Belongs to the universal ribosomal protein uL29 family
KFF03_RS00900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFF03_RS00905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFF03_RS00910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFF03_RS00915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFF03_RS00920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFF03_RS00925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFF03_RS00930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFF03_RS00935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFF03_RS00940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFF03_RS00945	COG1841	ribosomal large subunit assembly
KFF03_RS00950	COG0200	Binds to the 23S rRNA
KFF03_RS00960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFF03_RS00965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFF03_RS00970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFF03_RS00975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFF03_RS00980	COG0202	RNA polymerase activity
KFF03_RS00985	COG0203	ribosomal protein L17
KFF03_RS01005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFF03_RS01015	COG3300	MHYT domain
KFF03_RS01015	COG5001	Diguanylate cyclase
KFF03_RS01035	COG1294	oxidase, subunit
KFF03_RS01040	COG4890	Cyd operon protein YbgT
KFF03_RS01050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFF03_RS01065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFF03_RS01090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFF03_RS01095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFF03_RS01095	COG2111	Na H antiporter
KFF03_RS01100	COG1006	Multisubunit Na H antiporter MnhC subunit
KFF03_RS01105	COG0651	ATP synthesis coupled electron transport
KFF03_RS01110	COG1863	multisubunit Na H antiporter MnhE subunit
KFF03_RS01115	COG2212	antiporter activity
KFF03_RS01120	COG1320	monovalent cation:proton antiporter activity
KFF03_RS01145	COG0583	DNA-binding transcription factor activity
KFF03_RS01155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFF03_RS01180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFF03_RS01185	COG1981	membrane
KFF03_RS01195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFF03_RS01210	COG0316	Belongs to the HesB IscA family
KFF03_RS01225	COG0739	heme binding
KFF03_RS01300	COG2755	lipolytic protein G-D-S-L family
KFF03_RS01300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KFF03_RS01320	COG1216	Glycosyl transferase, family 2
KFF03_RS01345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFF03_RS01380	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS01415	COG2203	Gaf domain
KFF03_RS01415	COG3706	GGDEF domain
KFF03_RS01415	COG4251	negative regulation of phosphorylation
KFF03_RS01415	COG5001	Diguanylate cyclase
KFF03_RS01420	COG0210	DNA helicase
KFF03_RS01425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFF03_RS01435	COG1360	Flagellar Motor Protein
KFF03_RS01440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KFF03_RS01445	COG1722	exodeoxyribonuclease VII activity
KFF03_RS01450	COG0142	geranyltranstransferase activity
KFF03_RS01455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KFF03_RS01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF03_RS01460	COG4191	Histidine kinase
KFF03_RS01465	COG2204	response regulator
KFF03_RS01470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFF03_RS01475	COG2738	Putative neutral zinc metallopeptidase
KFF03_RS01490	COG0573	inorganic phosphate transmembrane transporter activity
KFF03_RS01500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFF03_RS01515	COG4221	oxidoreductase activity
KFF03_RS01535	COG2239	Acts as a magnesium transporter
KFF03_RS01545	COG1660	Displays ATPase and GTPase activities
KFF03_RS01565	COG1137	ATPase activity
KFF03_RS01570	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KFF03_RS01590	COG1127	ABC transporter
KFF03_RS01595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KFF03_RS01600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KFF03_RS01610	COG5007	Belongs to the BolA IbaG family
KFF03_RS01615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFF03_RS01620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KFF03_RS01625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFF03_RS01630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFF03_RS01675	COG0328	RNA-DNA hybrid ribonuclease activity
KFF03_RS01675	COG3341	Caulimovirus viroplasmin
KFF03_RS01705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFF03_RS01710	COG0583	DNA-binding transcription factor activity
KFF03_RS01720	COG1918	ferrous iron import across plasma membrane
KFF03_RS01745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF03_RS01765	COG1047	Peptidyl-prolyl cis-trans
KFF03_RS01770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KFF03_RS01780	COG0840	transmembrane signaling receptor activity
KFF03_RS01785	COG0840	transmembrane signaling receptor activity
KFF03_RS01795	COG0557	exoribonuclease II activity
KFF03_RS01800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFF03_RS01820	COG0427	acetyl-CoA hydrolase
KFF03_RS01830	COG0583	DNA-binding transcription factor activity
KFF03_RS01850	COG0668	transmembrane transport
KFF03_RS01855	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KFF03_RS01880	COG3634	alkyl hydroperoxide reductase activity
KFF03_RS01950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFF03_RS01975	COG3540	Alkaline phosphatase
KFF03_RS01980	COG0739	heme binding
KFF03_RS01985	COG4771	TonB-dependent receptor
KFF03_RS02000	COG0523	cobalamin synthesis protein
KFF03_RS02005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFF03_RS02020	COG0583	DNA-binding transcription factor activity
KFF03_RS02025	COG1183	phosphatidylcholine synthase activity
KFF03_RS02030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFF03_RS02075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFF03_RS02085	COG0456	acetyltransferase
KFF03_RS02095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KFF03_RS02105	COG1115	amino acid carrier protein
KFF03_RS02110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFF03_RS02120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFF03_RS02125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFF03_RS02130	COG0723	plastoquinol--plastocyanin reductase activity
KFF03_RS02135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KFF03_RS02140	COG2857	Cytochrome c1
KFF03_RS02145	COG0625	glutathione transferase activity
KFF03_RS02150	COG2969	positive regulation of protein catabolic process
KFF03_RS02155	COG1309	transcriptional regulator
KFF03_RS02160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFF03_RS02170	COG0756	dUTP diphosphatase activity
KFF03_RS02175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFF03_RS02180	COG2003	Belongs to the UPF0758 family
KFF03_RS02185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFF03_RS02190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFF03_RS02195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFF03_RS02205	COG0405	Gamma-glutamyltransferase
KFF03_RS02210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KFF03_RS02225	COG0537	adenosine 5'-monophosphoramidase activity
KFF03_RS02230	COG1119	ATPase activity
KFF03_RS02235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KFF03_RS02240	COG1309	transcriptional regulator
KFF03_RS02245	COG1012	belongs to the aldehyde dehydrogenase family
KFF03_RS02265	COG4175	Glycine betaine
KFF03_RS02275	COG1846	Transcriptional regulator
KFF03_RS02280	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS02290	COG1309	transcriptional regulator
KFF03_RS02305	COG1079	Belongs to the binding-protein-dependent transport system permease family
KFF03_RS02315	COG3845	ABC transporter
KFF03_RS02325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KFF03_RS02355	COG0402	S-adenosylhomocysteine deaminase activity
KFF03_RS02375	COG0384	phenazine biosynthesis protein PhzF
KFF03_RS02410	COG2207	Transcriptional regulator
KFF03_RS02440	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KFF03_RS02445	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KFF03_RS02450	COG0235	Class ii aldolase
KFF03_RS02455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KFF03_RS02460	COG0778	Nitroreductase
KFF03_RS02465	COG0166	Belongs to the GPI family
KFF03_RS02470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KFF03_RS02475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KFF03_RS02480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFF03_RS02485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFF03_RS02490	COG0617	tRNA 3'-terminal CCA addition
KFF03_RS02500	COG3852	Histidine kinase
KFF03_RS02515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KFF03_RS02520	COG0436	Aminotransferase
KFF03_RS02525	COG1489	DNA binding
KFF03_RS02540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFF03_RS02560	COG0417	DNA replication proofreading
KFF03_RS02585	COG1858	cytochrome C peroxidase
KFF03_RS02590	COG0647	UMP catabolic process
KFF03_RS02595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KFF03_RS02620	COG1917	Cupin 2, conserved barrel domain protein
KFF03_RS02620	COG4977	sequence-specific DNA binding
KFF03_RS02630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF03_RS02640	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KFF03_RS02645	COG2894	cell division
KFF03_RS02675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KFF03_RS02685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF03_RS02715	COG4206	TonB-dependent receptor
KFF03_RS02725	COG1785	Belongs to the alkaline phosphatase family
KFF03_RS02745	COG4774	siderophore transport
KFF03_RS02760	COG0360	Binds together with S18 to 16S ribosomal RNA
KFF03_RS02765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFF03_RS02780	COG0305	Participates in initiation and elongation during chromosome replication
KFF03_RS02820	COG4977	sequence-specific DNA binding
KFF03_RS02825	COG4667	esterase of the alpha-beta hydrolase superfamily
KFF03_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS02875	COG2205	protein histidine kinase activity
KFF03_RS02880	COG0745	RESPONSE REGULATOR receiver
KFF03_RS02895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFF03_RS02900	COG2315	Protein conserved in bacteria
KFF03_RS02905	COG1024	Enoyl-CoA hydratase
KFF03_RS02930	COG4067	protein conserved in archaea
KFF03_RS02930	COG0189	ligase activity
KFF03_RS02950	COG0497	DNA recombination
KFF03_RS02955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFF03_RS02960	COG0443	Heat shock 70 kDa protein
KFF03_RS02965	COG0484	heat shock protein binding
KFF03_RS02970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFF03_RS02985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFF03_RS02995	COG2814	Major facilitator Superfamily
KFF03_RS03000	COG1607	acyl-coa hydrolase
KFF03_RS03005	COG2207	Transcriptional regulator
KFF03_RS03015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFF03_RS03035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KFF03_RS03040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFF03_RS03045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFF03_RS03050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFF03_RS03055	COG0149	triose-phosphate isomerase activity
KFF03_RS03070	COG0779	Required for maturation of 30S ribosomal subunits
KFF03_RS03075	COG0195	Participates in both transcription termination and antitermination
KFF03_RS03085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFF03_RS03090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFF03_RS03095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFF03_RS03100	COG1185	polyribonucleotide nucleotidyltransferase activity
KFF03_RS03120	COG2832	Protein of unknown function (DUF454)
KFF03_RS03145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFF03_RS03155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFF03_RS03160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFF03_RS03190	COG1677	Flagellar hook-basal body complex protein FliE
KFF03_RS03225	COG0745	RESPONSE REGULATOR receiver
KFF03_RS03230	COG0643	Histidine kinase
KFF03_RS03230	COG2198	Histidine kinase
KFF03_RS03235	COG0835	chemotaxis
KFF03_RS03250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KFF03_RS03255	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KFF03_RS03260	COG2201	protein-glutamate methylesterase activity
KFF03_RS03270	COG0745	RESPONSE REGULATOR receiver
KFF03_RS03350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KFF03_RS03355	COG0784	Response regulator, receiver
KFF03_RS03355	COG0643	Histidine kinase
KFF03_RS03355	COG2198	Histidine kinase
KFF03_RS03360	COG2201	protein-glutamate methylesterase activity
KFF03_RS03365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KFF03_RS03375	COG1192	Involved in chromosome partitioning
KFF03_RS03395	COG0835	chemotaxis
KFF03_RS03420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFF03_RS03430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFF03_RS03440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFF03_RS03445	COG0745	RESPONSE REGULATOR receiver
KFF03_RS03455	COG0583	DNA-binding transcription factor activity
KFF03_RS03460	COG0840	transmembrane signaling receptor activity
KFF03_RS03475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KFF03_RS03475	COG0678	peroxiredoxin activity
KFF03_RS03510	COG0495	leucyl-tRNA aminoacylation
KFF03_RS03520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFF03_RS03540	COG0745	RESPONSE REGULATOR receiver
KFF03_RS03545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFF03_RS03560	COG1215	transferase activity, transferring glycosyl groups
KFF03_RS03575	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS03580	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS03595	COG2244	polysaccharide biosynthetic process
KFF03_RS03620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KFF03_RS03665	COG0583	DNA-binding transcription factor activity
KFF03_RS03685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFF03_RS03715	COG0415	Belongs to the DNA photolyase family
KFF03_RS03720	COG0789	Transcriptional regulator
KFF03_RS03735	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KFF03_RS03740	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS03760	COG0415	Belongs to the DNA photolyase family
KFF03_RS03765	COG0415	Belongs to the DNA photolyase family
KFF03_RS03775	COG3046	protein related to deoxyribodipyrimidine photolyase
KFF03_RS03780	COG0069	glutamate synthase activity
KFF03_RS03795	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KFF03_RS03805	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFF03_RS03810	COG0840	transmembrane signaling receptor activity
KFF03_RS03815	COG1797	cobyrinic acid a,c-diamide synthase activity
KFF03_RS03820	COG2096	Adenosyltransferase
KFF03_RS03835	COG0668	transmembrane transport
KFF03_RS03840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFF03_RS03850	COG1666	GTP binding
KFF03_RS03860	COG0604	alcohol dehydrogenase
KFF03_RS03865	COG0602	queuosine metabolic process
KFF03_RS03870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFF03_RS03905	COG0590	tRNA wobble adenosine to inosine editing
KFF03_RS03910	COG0513	Belongs to the DEAD box helicase family
KFF03_RS03915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KFF03_RS03925	COG0052	Belongs to the universal ribosomal protein uS2 family
KFF03_RS03930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFF03_RS03935	COG0528	UMP kinase activity
KFF03_RS03940	COG0233	cytoplasmic translational termination
KFF03_RS03955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KFF03_RS03975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF03_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFF03_RS03985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF03_RS03990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF03_RS03995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFF03_RS04005	COG2081	HI0933 family
KFF03_RS04010	COG0840	transmembrane signaling receptor activity
KFF03_RS04015	COG1725	Transcriptional regulator
KFF03_RS04040	COG2144	transferase activity, transferring acyl groups
KFF03_RS04050	COG2072	flavoprotein involved in K transport
KFF03_RS04060	COG3038	cytochrome b561
KFF03_RS04070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFF03_RS04080	COG0386	Belongs to the glutathione peroxidase family
KFF03_RS04085	COG0583	DNA-binding transcription factor activity
KFF03_RS04095	COG1902	pentaerythritol trinitrate reductase activity
KFF03_RS04125	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS04130	COG0840	transmembrane signaling receptor activity
KFF03_RS04135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFF03_RS04140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFF03_RS04145	COG0840	transmembrane signaling receptor activity
KFF03_RS04160	COG0358	DNA primase activity
KFF03_RS04170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KFF03_RS04175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFF03_RS04180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFF03_RS04185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFF03_RS04185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFF03_RS04190	COG0617	tRNA 3'-terminal CCA addition
KFF03_RS04215	COG2719	SpoVR family
KFF03_RS04220	COG2718	Belongs to the UPF0229 family
KFF03_RS04225	COG2766	serine protein kinase
KFF03_RS04235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFF03_RS04240	COG2967	ApaG domain
KFF03_RS04245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFF03_RS04250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KFF03_RS04255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF03_RS04260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KFF03_RS04265	COG3178	'Phosphotransferase
KFF03_RS04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFF03_RS04275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KFF03_RS04285	COG1272	protein, Hemolysin III
KFF03_RS04290	COG2827	Endonuclease containing a URI domain
KFF03_RS04320	COG0424	maF-like protein
KFF03_RS04325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFF03_RS04375	COG1611	Belongs to the LOG family
KFF03_RS04380	COG2239	Acts as a magnesium transporter
KFF03_RS04390	COG0183	Belongs to the thiolase family
KFF03_RS04410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KFF03_RS04415	COG1040	competence protein
KFF03_RS04420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFF03_RS04435	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS04440	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS04465	COG0512	Glutamine amidotransferase of anthranilate synthase
KFF03_RS04470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFF03_RS04475	COG0134	indole-3-glycerol-phosphate synthase activity
KFF03_RS04490	COG2161	toxin-antitoxin pair type II binding
KFF03_RS04495	COG4115	mRNA cleavage
KFF03_RS04505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFF03_RS04515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFF03_RS04515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFF03_RS04520	COG0509	glycine decarboxylation via glycine cleavage system
KFF03_RS04525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KFF03_RS04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF03_RS04565	COG0450	alkyl hydroperoxide reductase
KFF03_RS04575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFF03_RS04580	COG0596	Alpha beta hydrolase
KFF03_RS04580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFF03_RS04580	COG2226	methyltransferase
KFF03_RS04590	COG0156	8-amino-7-oxononanoate synthase activity
KFF03_RS04610	COG3604	Transcriptional regulator
KFF03_RS04635	COG0275	rRNA processing
KFF03_RS04655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFF03_RS04660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFF03_RS04665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFF03_RS04670	COG0772	Belongs to the SEDS family
KFF03_RS04675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFF03_RS04680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFF03_RS04685	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFF03_RS04690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KFF03_RS04700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFF03_RS04705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KFF03_RS04710	COG0739	heme binding
KFF03_RS04715	COG0653	protein targeting
KFF03_RS04725	COG0494	nUDIX hydrolase
KFF03_RS04745	COG4535	Mg2 and Co2 transporter CorC
KFF03_RS04750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFF03_RS04755	COG1702	phosphate starvation-inducible protein PhoH
KFF03_RS04760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFF03_RS04780	COG1309	transcriptional regulator
KFF03_RS04790	COG0193	aminoacyl-tRNA hydrolase activity
KFF03_RS04795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFF03_RS04800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFF03_RS04810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFF03_RS04825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFF03_RS04830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFF03_RS04835	COG2890	protein-(glutamine-N5) methyltransferase activity
KFF03_RS04850	COG0792	nuclease activity
KFF03_RS04855	COG3107	peptidoglycan biosynthetic process
KFF03_RS04875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFF03_RS04880	COG1607	acyl-coa hydrolase
KFF03_RS04885	COG1024	Enoyl-CoA hydratase
KFF03_RS04900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF03_RS04925	COG0432	Pfam Uncharacterised protein family UPF0047
KFF03_RS04930	COG0069	glutamate synthase activity
KFF03_RS04955	COG1063	alcohol dehydrogenase
KFF03_RS04960	COG4172	Belongs to the ABC transporter superfamily
KFF03_RS04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFF03_RS04970	COG0601	transmembrane transport
KFF03_RS04975	COG0747	negative chemotaxis
KFF03_RS04990	COG3706	GGDEF domain
KFF03_RS05005	COG2193	ferroxidase activity
KFF03_RS05010	COG1639	'signal transduction protein
KFF03_RS05015	COG2084	Dehydrogenase
KFF03_RS05020	COG3622	Belongs to the hyi family
KFF03_RS05025	COG3313	Fe-S protein
KFF03_RS05030	COG1278	Cold shock
KFF03_RS05035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFF03_RS05065	COG4302	ethanolamine ammonia-lyase activity
KFF03_RS05070	COG4303	Ethanolamine ammonia lyase large subunit
KFF03_RS05080	COG0004	ammonium transporteR
KFF03_RS05085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFF03_RS05175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KFF03_RS05200	COG4335	DNA alkylation repair
KFF03_RS05220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KFF03_RS05225	COG1917	Cupin 2, conserved barrel domain protein
KFF03_RS05230	COG0288	reversible hydration of carbon dioxide
KFF03_RS05240	COG2181	nitrate reductase activity
KFF03_RS05245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KFF03_RS05250	COG1140	nitrate reductase beta subunit
KFF03_RS05255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KFF03_RS05260	COG3850	Histidine kinase
KFF03_RS05270	COG2223	nitrite transmembrane transporter activity
KFF03_RS05275	COG2197	response regulator
KFF03_RS05280	COG0303	'Molybdopterin
KFF03_RS05295	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFF03_RS05300	COG0746	molybdenum cofactor guanylyltransferase activity
KFF03_RS05325	COG2223	nitrite transmembrane transporter activity
KFF03_RS05355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFF03_RS05370	COG3268	Saccharopine dehydrogenase
KFF03_RS05375	COG0640	Transcriptional regulator
KFF03_RS05385	COG0798	PFAM Bile acid sodium symporter
KFF03_RS05390	COG0431	NADPH-dependent FMN reductase
KFF03_RS05430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFF03_RS05430	COG4651	solute:proton antiporter activity
KFF03_RS05450	COG0590	tRNA wobble adenosine to inosine editing
KFF03_RS05460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KFF03_RS05465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFF03_RS05465	COG0047	phosphoribosylformylglycinamidine synthase activity
KFF03_RS05485	COG3118	belongs to the thioredoxin family
KFF03_RS05495	COG1283	sodium-dependent phosphate transmembrane transporter activity
KFF03_RS05515	COG0574	Belongs to the PEP-utilizing enzyme family
KFF03_RS05515	COG3848	Pyruvate phosphate dikinase
KFF03_RS05535	COG0228	four-way junction DNA binding
KFF03_RS05540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFF03_RS05545	COG0336	Belongs to the RNA methyltransferase TrmD family
KFF03_RS05550	COG0335	large ribosomal subunit rRNA binding
KFF03_RS05555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KFF03_RS05580	COG2264	protein methyltransferase activity
KFF03_RS05605	COG0632	four-way junction helicase activity
KFF03_RS05610	COG2255	four-way junction helicase activity
KFF03_RS05615	COG0824	Thioesterase
KFF03_RS05635	COG0823	Involved in the tonB-independent uptake of proteins
KFF03_RS05660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KFF03_RS05665	COG4783	chaperone-mediated protein folding
KFF03_RS05670	COG0425	Belongs to the sulfur carrier protein TusA family
KFF03_RS05680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFF03_RS05690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFF03_RS05695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFF03_RS05705	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KFF03_RS05725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFF03_RS05735	COG0084	hydrolase, TatD family'
KFF03_RS05745	COG0306	phosphate transporter
KFF03_RS05750	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KFF03_RS05775	COG1309	transcriptional regulator
KFF03_RS05780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KFF03_RS05785	COG0732	type I restriction modification DNA specificity domain
KFF03_RS05800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KFF03_RS05805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KFF03_RS05825	COG2267	carboxylic ester hydrolase activity
KFF03_RS05830	COG2925	Exonuclease
KFF03_RS05840	COG4251	negative regulation of phosphorylation
KFF03_RS05840	COG5001	Diguanylate cyclase
KFF03_RS05840	COG3706	GGDEF domain
KFF03_RS05840	COG2203	Gaf domain
KFF03_RS05850	COG2204	response regulator
KFF03_RS05880	COG0667	Aldo Keto reductase
KFF03_RS05890	COG0840	transmembrane signaling receptor activity
KFF03_RS05895	COG0747	negative chemotaxis
KFF03_RS05900	COG2267	carboxylic ester hydrolase activity
KFF03_RS05905	COG0681	Belongs to the peptidase S26 family
KFF03_RS05920	COG0429	hydrolase of the alpha beta-hydrolase fold
KFF03_RS06005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFF03_RS06010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFF03_RS06015	COG0705	Rhomboid family
KFF03_RS06020	COG3139	Protein of unknown function (DUF1315)
KFF03_RS06045	COG0308	aminopeptidase N
KFF03_RS06115	COG0488	(ABC) transporter
KFF03_RS06135	COG3130	regulation of translation
KFF03_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS06180	COG0402	S-adenosylhomocysteine deaminase activity
KFF03_RS06195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KFF03_RS06205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFF03_RS06210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFF03_RS06215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFF03_RS06225	COG0776	regulation of translation
KFF03_RS06235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KFF03_RS06240	COG0284	orotidine-5'-phosphate decarboxylase activity
KFF03_RS06270	COG0463	Glycosyl transferase, family 2
KFF03_RS06280	COG0367	asparagine synthase
KFF03_RS06305	COG2192	nodulation
KFF03_RS06325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KFF03_RS06335	COG0717	Belongs to the dCTP deaminase family
KFF03_RS06345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFF03_RS06365	COG0436	Aminotransferase
KFF03_RS06370	COG0556	nucleotide-excision repair
KFF03_RS06390	COG0488	(ABC) transporter
KFF03_RS06410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFF03_RS06415	COG2996	Protein conserved in bacteria
KFF03_RS06420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF03_RS06430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFF03_RS06445	COG2223	nitrite transmembrane transporter activity
KFF03_RS06450	COG0425	Belongs to the sulfur carrier protein TusA family
KFF03_RS06460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFF03_RS06465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFF03_RS06470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFF03_RS06480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFF03_RS06485	COG0072	phenylalanine-tRNA ligase activity
KFF03_RS06490	COG0776	regulation of translation
KFF03_RS06575	COG4964	Belongs to the GSP D family
KFF03_RS06630	COG0840	transmembrane signaling receptor activity
KFF03_RS06645	COG1575	Belongs to the MenA family. Type 1 subfamily
KFF03_RS06650	COG0259	pyridoxamine-phosphate oxidase activity
KFF03_RS06660	COG3047	cAMP biosynthetic process
KFF03_RS06670	COG0302	gtp cyclohydrolase
KFF03_RS06675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFF03_RS06685	COG3706	GGDEF domain
KFF03_RS06705	COG3115	cell septum assembly
KFF03_RS06705	COG3115	cell septum assembly
KFF03_RS06710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFF03_RS06750	COG0714	Associated with various cellular activities
KFF03_RS06785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFF03_RS06790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFF03_RS06795	COG2176	DNA-directed DNA polymerase activity
KFF03_RS06805	COG1733	regulation of RNA biosynthetic process
KFF03_RS06835	COG2165	general secretion pathway protein
KFF03_RS06850	COG3220	belongs to the UPF0276 family
KFF03_RS06860	COG0668	transmembrane transport
KFF03_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS06870	COG0625	glutathione transferase activity
KFF03_RS06880	COG1012	belongs to the aldehyde dehydrogenase family
KFF03_RS06895	COG4591	ABC-type transport system involved in lipoprotein release permease component
KFF03_RS06910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFF03_RS06960	COG3706	GGDEF domain
KFF03_RS06970	COG0004	ammonium transporteR
KFF03_RS06985	COG1024	Enoyl-CoA hydratase
KFF03_RS06985	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF03_RS06990	COG0183	Belongs to the thiolase family
KFF03_RS07000	COG2814	Major facilitator Superfamily
KFF03_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF03_RS07005	COG1024	Enoyl-CoA hydratase
KFF03_RS07010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF03_RS07040	COG2010	Cytochrome c
KFF03_RS07055	COG3278	Belongs to the heme-copper respiratory oxidase family
KFF03_RS07075	COG1024	Enoyl-CoA hydratase
KFF03_RS07075	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF03_RS07125	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF03_RS07140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF03_RS07155	COG0307	riboflavin synthase, alpha
KFF03_RS07170	COG0784	Response regulator, receiver
KFF03_RS07170	COG2205	protein histidine kinase activity
KFF03_RS07185	COG1643	Atp-dependent helicase
KFF03_RS07195	COG5001	Diguanylate cyclase
KFF03_RS07195	COG3300	MHYT domain
KFF03_RS07215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFF03_RS07215	COG0519	Catalyzes the synthesis of GMP from XMP
KFF03_RS07220	COG3530	Putative quorum-sensing-regulated virulence factor
KFF03_RS07235	COG3123	guanosine phosphorylase activity
KFF03_RS07240	COG4191	Histidine kinase
KFF03_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF03_RS07245	COG0513	Belongs to the DEAD box helicase family
KFF03_RS07260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KFF03_RS07275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFF03_RS07280	COG2203	Gaf domain
KFF03_RS07280	COG4251	negative regulation of phosphorylation
KFF03_RS07280	COG5001	Diguanylate cyclase
KFF03_RS07280	COG3706	GGDEF domain
KFF03_RS07285	COG0204	Acyl-transferase
KFF03_RS07295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KFF03_RS07310	COG3706	GGDEF domain
KFF03_RS07310	COG2203	Gaf domain
KFF03_RS07310	COG4251	negative regulation of phosphorylation
KFF03_RS07310	COG5001	Diguanylate cyclase
KFF03_RS07345	COG2257	FlhB HrpN YscU SpaS Family
KFF03_RS07355	COG4133	protoheme IX ABC transporter activity
KFF03_RS07360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KFF03_RS07375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KFF03_RS07380	COG1138	Cytochrome C-type biogenesis protein
KFF03_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF03_RS07400	COG0824	Thioesterase
KFF03_RS07430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFF03_RS07435	COG2171	N-acyltransferase activity
KFF03_RS07440	COG1393	Belongs to the ArsC family
KFF03_RS07455	COG0840	transmembrane signaling receptor activity
KFF03_RS07460	COG0400	carboxylic ester hydrolase activity
KFF03_RS07475	COG0180	Tryptophanyl-tRNA synthetase
KFF03_RS07510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KFF03_RS07520	COG0175	sulfate reduction
KFF03_RS07535	COG1196	nuclear chromosome segregation
KFF03_RS07535	COG0739	heme binding
KFF03_RS07535	COG0741	lytic transglycosylase activity
KFF03_RS07540	COG0442	prolyl-tRNA aminoacylation
KFF03_RS07550	COG1648	precorrin-2 dehydrogenase activity
KFF03_RS07550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFF03_RS07555	COG0243	molybdopterin cofactor binding
KFF03_RS07565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF03_RS07570	COG2146	nitrite reductase [NAD(P)H] activity
KFF03_RS07575	COG2223	nitrite transmembrane transporter activity
KFF03_RS07580	COG0515	serine threonine protein kinase
KFF03_RS07580	COG2815	serine threonine protein kinase
KFF03_RS07585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF03_RS07595	COG1116	anion transmembrane transporter activity
KFF03_RS07605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF03_RS07610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF03_RS07610	COG1116	anion transmembrane transporter activity
KFF03_RS07615	COG3707	response regulator
KFF03_RS07630	COG1067	ATP-dependent peptidase activity
KFF03_RS07645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFF03_RS07650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFF03_RS07655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFF03_RS07665	COG3100	YcgL domain-containing protein
KFF03_RS07670	COG2983	Belongs to the UPF0260 family
KFF03_RS07690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFF03_RS07770	COG1178	ABC-type Fe3 transport system permease component
KFF03_RS07775	COG1840	ABC-type Fe3 transport system, periplasmic component
KFF03_RS07785	COG0436	Aminotransferase
KFF03_RS07795	COG0386	Belongs to the glutathione peroxidase family
KFF03_RS07800	COG1846	Transcriptional regulator
KFF03_RS07845	COG1131	(ABC) transporter
KFF03_RS07850	COG0842	Transport permease protein
KFF03_RS07855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFF03_RS07855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFF03_RS07865	COG0778	Nitroreductase
KFF03_RS07885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFF03_RS07900	COG0589	response to stress
KFF03_RS07910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFF03_RS07915	COG0066	3-isopropylmalate dehydratase activity
KFF03_RS07920	COG0473	3-isopropylmalate dehydrogenase activity
KFF03_RS07935	COG0101	tRNA pseudouridine synthase activity
KFF03_RS07940	COG0135	phosphoribosylanthranilate isomerase activity
KFF03_RS07950	COG0159	tryptophan synthase activity
KFF03_RS07955	COG0285	dihydrofolate synthase activity
KFF03_RS07965	COG1286	toxin biosynthetic process
KFF03_RS07980	COG0714	Associated with various cellular activities
KFF03_RS08005	COG3118	belongs to the thioredoxin family
KFF03_RS08010	COG0667	Aldo Keto reductase
KFF03_RS08050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFF03_RS08055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFF03_RS08065	COG0582	viral genome integration into host DNA
KFF03_RS08075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFF03_RS08080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KFF03_RS08105	COG0602	queuosine metabolic process
KFF03_RS08165	COG0678	peroxiredoxin activity
KFF03_RS08165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KFF03_RS08170	COG3101	peptidyl-lysine hydroxylation
KFF03_RS08190	COG0659	secondary active sulfate transmembrane transporter activity
KFF03_RS08205	COG1858	cytochrome C peroxidase
KFF03_RS08210	COG0443	Heat shock 70 kDa protein
KFF03_RS08240	COG0243	molybdopterin cofactor binding
KFF03_RS08245	COG4660	Part of a membrane complex involved in electron transport
KFF03_RS08255	COG4658	electron transport chain
KFF03_RS08260	COG4656	Part of a membrane complex involved in electron transport
KFF03_RS08265	COG2878	Part of a membrane complex involved in electron transport
KFF03_RS08270	COG4657	Part of a membrane complex involved in electron transport
KFF03_RS08275	COG0489	protein tyrosine kinase activity
KFF03_RS08280	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFF03_RS08280	COG1902	pentaerythritol trinitrate reductase activity
KFF03_RS08285	COG3852	Histidine kinase
KFF03_RS08300	COG0564	pseudouridine synthase activity
KFF03_RS08325	COG0840	transmembrane signaling receptor activity
KFF03_RS08345	COG0494	nUDIX hydrolase
KFF03_RS08365	COG2199	diguanylate cyclase activity
KFF03_RS08380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFF03_RS08400	COG3713	MltA-interacting MipA family protein
KFF03_RS08420	COG5265	(ABC) transporter
KFF03_RS08425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFF03_RS08445	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KFF03_RS08455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KFF03_RS08480	COG0730	response to heat
KFF03_RS08490	COG1530	ribonuclease E activity
KFF03_RS08500	COG0564	pseudouridine synthase activity
KFF03_RS08510	COG0616	signal peptide processing
KFF03_RS08515	COG1399	metal-binding, possibly nucleic acid-binding protein
KFF03_RS08520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFF03_RS08525	COG0416	fatty acid biosynthetic process
KFF03_RS08530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KFF03_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFF03_RS08545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFF03_RS08550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFF03_RS08555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFF03_RS08560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFF03_RS08575	COG1104	cysteine desulfurase activity
KFF03_RS08590	COG0811	peptide transport
KFF03_RS08595	COG0811	peptide transport
KFF03_RS08600	COG0848	biopolymer transport protein
KFF03_RS08605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KFF03_RS08625	COG0583	DNA-binding transcription factor activity
KFF03_RS08635	COG2059	Chromate
KFF03_RS08675	COG1054	Belongs to the UPF0176 family
KFF03_RS08690	COG4221	oxidoreductase activity
KFF03_RS08695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KFF03_RS08700	COG2205	protein histidine kinase activity
KFF03_RS08705	COG0745	RESPONSE REGULATOR receiver
KFF03_RS08765	COG0525	valine-tRNA ligase activity
KFF03_RS08780	COG2226	methyltransferase
KFF03_RS08785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFF03_RS08790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFF03_RS08835	COG0659	secondary active sulfate transmembrane transporter activity
KFF03_RS08840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF03_RS08845	COG2267	carboxylic ester hydrolase activity
KFF03_RS08865	COG1136	(ABC) transporter
KFF03_RS08875	COG2333	competence protein COMEC
KFF03_RS08875	COG0658	competence protein
KFF03_RS08880	COG0811	peptide transport
KFF03_RS08885	COG0848	biopolymer transport protein
KFF03_RS08890	COG1132	(ABC) transporter
KFF03_RS08895	COG1663	tetraacyldisaccharide 4'-kinase activity
KFF03_RS08900	COG2835	tetraacyldisaccharide 4'-kinase activity
KFF03_RS08905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFF03_RS08915	COG0708	Exodeoxyribonuclease III
KFF03_RS08925	COG4191	Histidine kinase
KFF03_RS08935	COG0741	lytic transglycosylase activity
KFF03_RS08935	COG1388	LysM domain
KFF03_RS08945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFF03_RS08950	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KFF03_RS08965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFF03_RS08965	COG0301	tRNA thio-modification
KFF03_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS08985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KFF03_RS09000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KFF03_RS09050	COG2165	general secretion pathway protein
KFF03_RS09085	COG0625	glutathione transferase activity
KFF03_RS09105	COG0582	viral genome integration into host DNA
KFF03_RS09160	COG2197	response regulator
KFF03_RS09165	COG0045	succinate-CoA ligase (ADP-forming) activity
KFF03_RS09165	COG1042	CoA-binding domain protein
KFF03_RS09165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFF03_RS09170	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFF03_RS09180	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KFF03_RS09185	COG2920	part of a sulfur-relay system
KFF03_RS09195	COG0840	transmembrane signaling receptor activity
KFF03_RS09200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFF03_RS09200	COG1648	precorrin-2 dehydrogenase activity
KFF03_RS09205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFF03_RS09210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFF03_RS09215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFF03_RS09220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KFF03_RS09230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KFF03_RS09235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KFF03_RS09240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFF03_RS09245	COG0542	response to heat
KFF03_RS09250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KFF03_RS09265	COG1187	pseudouridine synthase activity
KFF03_RS09280	COG2915	High frequency lysogenization protein hflD homolog
KFF03_RS09285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFF03_RS09295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFF03_RS09325	COG0826	peptidase U32
KFF03_RS09365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFF03_RS09375	COG2204	response regulator
KFF03_RS09405	COG0534	Mate efflux family protein
KFF03_RS09410	COG0584	glycerophosphoryl diester phosphodiesterase
KFF03_RS09415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF03_RS09425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFF03_RS09425	COG4651	solute:proton antiporter activity
KFF03_RS09430	COG0823	Involved in the tonB-independent uptake of proteins
KFF03_RS09445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF03_RS09445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF03_RS09450	COG0346	lactoylglutathione lyase activity
KFF03_RS09455	COG0439	Biotin carboxylase
KFF03_RS09470	COG0702	epimerase
KFF03_RS09485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFF03_RS09525	COG0560	Phosphoserine phosphatase
KFF03_RS09550	COG1862	Preprotein translocase
KFF03_RS09555	COG0343	queuine tRNA-ribosyltransferase activity
KFF03_RS09560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFF03_RS09580	COG0840	transmembrane signaling receptor activity
KFF03_RS09580	COG3290	protein histidine kinase activity
KFF03_RS09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF03_RS09610	COG1477	protein flavinylation
KFF03_RS09625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFF03_RS09630	COG1074	ATP-dependent DNA helicase activity
KFF03_RS09635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KFF03_RS09640	COG0686	Belongs to the AlaDH PNT family
KFF03_RS09650	COG0840	transmembrane signaling receptor activity
KFF03_RS09655	COG0604	alcohol dehydrogenase
KFF03_RS09660	COG0616	signal peptide processing
KFF03_RS09670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFF03_RS09680	COG1477	protein flavinylation
KFF03_RS09705	COG1739	Uncharacterized protein family UPF0029
KFF03_RS09710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF03_RS09725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KFF03_RS09730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFF03_RS09735	COG0740	serine-type endopeptidase activity
KFF03_RS09740	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFF03_RS09760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFF03_RS09765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF03_RS09770	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS09775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KFF03_RS09780	COG2204	response regulator
KFF03_RS09785	COG2204	response regulator
KFF03_RS09825	COG1215	transferase activity, transferring glycosyl groups
KFF03_RS09840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFF03_RS09850	COG0776	regulation of translation
KFF03_RS09855	COG1573	uracil-dna glycosylase
KFF03_RS09875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF03_RS09925	COG5499	transcription regulator containing HTH domain
KFF03_RS09930	COG4680	protein conserved in bacteria
KFF03_RS09935	COG0252	asparaginase activity
KFF03_RS09945	COG2824	Alkylphosphonate utilization operon protein PhnA
KFF03_RS09985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFF03_RS09995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KFF03_RS10035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFF03_RS10065	COG0215	cysteine-tRNA ligase activity
KFF03_RS10070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFF03_RS10075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFF03_RS10080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF03_RS10090	COG5002	protein histidine kinase activity
KFF03_RS10090	COG5001	Diguanylate cyclase
KFF03_RS10090	COG3447	MASE1 domain protein
KFF03_RS10095	COG2853	Lipoprotein
KFF03_RS10100	COG2259	Doxx family
KFF03_RS10110	COG3220	belongs to the UPF0276 family
KFF03_RS10120	COG1643	Atp-dependent helicase
KFF03_RS10125	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS10135	COG2030	dehydratase
KFF03_RS10145	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KFF03_RS10155	COG4977	sequence-specific DNA binding
KFF03_RS10200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFF03_RS10205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFF03_RS10215	COG0525	valine-tRNA ligase activity
KFF03_RS10225	COG1199	ATP-dependent helicase activity
KFF03_RS10230	COG3266	domain, Protein
KFF03_RS10235	COG3267	Type II secretory pathway component ExeA
KFF03_RS10235	COG3409	Peptidoglycan-binding domain 1 protein
KFF03_RS10250	COG1414	Transcriptional regulator
KFF03_RS10260	COG1454	alcohol dehydrogenase
KFF03_RS10275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KFF03_RS10305	COG2850	peptidyl-arginine hydroxylation
KFF03_RS10310	COG2153	protein acetylation
KFF03_RS10315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFF03_RS10325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KFF03_RS10350	COG1022	Amp-dependent synthetase and ligase
KFF03_RS10360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF03_RS10360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KFF03_RS10370	COG3089	Belongs to the UPF0270 family
KFF03_RS10395	COG2814	Major facilitator Superfamily
KFF03_RS10400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFF03_RS10445	COG1295	ribonuclease BN
KFF03_RS10450	COG1393	Belongs to the ArsC family
KFF03_RS10475	COG0795	lipopolysaccharide-transporting ATPase activity
KFF03_RS10480	COG0795	lipopolysaccharide-transporting ATPase activity
KFF03_RS10485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFF03_RS10495	COG1451	nucleotide metabolic process
KFF03_RS10505	COG0513	Belongs to the DEAD box helicase family
KFF03_RS10520	COG2252	PERMEase
KFF03_RS10525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFF03_RS10530	COG3081	Nucleoid-associated protein
KFF03_RS10535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KFF03_RS10555	COG0037	tRNA processing
KFF03_RS10565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFF03_RS10580	COG0045	succinate-CoA ligase (ADP-forming) activity
KFF03_RS10600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFF03_RS10605	COG1053	succinate dehydrogenase
KFF03_RS10610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KFF03_RS10630	COG0633	Ferredoxin
KFF03_RS10630	COG3217	Mosc domain protein beta barrel domain protein
KFF03_RS10640	COG0835	chemotaxis
KFF03_RS10640	COG0784	Response regulator, receiver
KFF03_RS10645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KFF03_RS10650	COG1070	Carbohydrate kinase
KFF03_RS10655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KFF03_RS10670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF03_RS10675	COG0513	Belongs to the DEAD box helicase family
KFF03_RS10680	COG0859	PFAM glycosyl transferase family 9
KFF03_RS10690	COG0463	Glycosyl transferase, family 2
KFF03_RS10695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KFF03_RS10715	COG0439	Biotin carboxylase
KFF03_RS10785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFF03_RS10785	COG0519	Catalyzes the synthesis of GMP from XMP
KFF03_RS10795	COG3064	Membrane
KFF03_RS10795	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KFF03_RS10795	COG1073	alpha beta
KFF03_RS10810	COG1570	exodeoxyribonuclease VII activity
KFF03_RS10835	COG1946	Acyl-CoA thioesterase
KFF03_RS10840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFF03_RS10845	COG0513	Belongs to the DEAD box helicase family
KFF03_RS10870	COG0730	response to heat
KFF03_RS10875	COG0077	Prephenate dehydratase
KFF03_RS10875	COG1605	Chorismate mutase
KFF03_RS10880	COG0572	uridine kinase
KFF03_RS10885	COG3769	mannosylglycerate metabolic process
KFF03_RS10890	COG1215	transferase activity, transferring glycosyl groups
KFF03_RS10935	COG0484	heat shock protein binding
KFF03_RS10965	COG0271	Belongs to the BolA IbaG family
KFF03_RS11000	COG1024	Enoyl-CoA hydratase
KFF03_RS11010	COG1253	flavin adenine dinucleotide binding
KFF03_RS11020	COG3022	response to hydroperoxide
KFF03_RS11030	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS11035	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS11050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFF03_RS11060	COG3122	Protein conserved in bacteria
KFF03_RS11065	COG2151	metal-sulfur cluster biosynthetic enzyme
KFF03_RS11120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFF03_RS11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF03_RS11125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFF03_RS11155	COG0366	Alpha amylase catalytic
KFF03_RS11160	COG0800	Aldolase
KFF03_RS11170	COG0363	glucosamine-6-phosphate deaminase activity
KFF03_RS11200	COG0545	Peptidyl-prolyl cis-trans isomerase
KFF03_RS11225	COG0676	glucose-6-phosphate 1-epimerase activity
KFF03_RS11240	COG0023	Translation Initiation Factor
KFF03_RS11245	COG4191	Histidine kinase
KFF03_RS11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF03_RS11250	COG0385	Bile acid
KFF03_RS11260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFF03_RS11315	COG1454	alcohol dehydrogenase
KFF03_RS11335	COG2207	Transcriptional regulator
KFF03_RS11345	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFF03_RS11360	COG1805	sodium ion transport
KFF03_RS11365	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFF03_RS11380	COG2202	Pas domain
KFF03_RS11380	COG2205	protein histidine kinase activity
KFF03_RS11390	COG0745	RESPONSE REGULATOR receiver
KFF03_RS11405	COG3008	intermembrane lipid transfer
KFF03_RS11405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KFF03_RS11410	COG2995	paraquat-inducible protein a
KFF03_RS11425	COG4191	Histidine kinase
KFF03_RS11475	COG3604	Transcriptional regulator
KFF03_RS11480	COG0348	domain, Protein
KFF03_RS11505	COG1472	Belongs to the glycosyl hydrolase 3 family
KFF03_RS11510	COG1376	ErfK ybiS ycfS ynhG family protein
KFF03_RS11520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFF03_RS11545	COG0326	Molecular chaperone. Has ATPase activity
KFF03_RS11550	COG0733	neurotransmitter:sodium symporter activity
KFF03_RS11555	COG2962	Rard protein
KFF03_RS11565	COG2022	thiamine diphosphate biosynthetic process
KFF03_RS11580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KFF03_RS11595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFF03_RS11620	COG1942	4-Oxalocrotonate Tautomerase
KFF03_RS11635	COG2188	Transcriptional regulator
KFF03_RS11645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF03_RS11665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFF03_RS11685	COG0583	DNA-binding transcription factor activity
KFF03_RS11705	COG3956	TIGRFAM MazG family protein
KFF03_RS11710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFF03_RS11715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFF03_RS11725	COG0784	Response regulator, receiver
KFF03_RS11725	COG2205	protein histidine kinase activity
KFF03_RS11725	COG5002	protein histidine kinase activity
KFF03_RS11730	COG0736	holo-[acyl-carrier-protein] synthase activity
KFF03_RS11745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFF03_RS11750	COG0571	ribonuclease III activity
KFF03_RS11760	COG0481	GTPase activity
KFF03_RS11765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFF03_RS11830	COG0840	transmembrane signaling receptor activity
KFF03_RS11850	COG0500	methyltransferase
KFF03_RS11855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFF03_RS11855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFF03_RS11875	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFF03_RS11890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KFF03_RS11915	COG0564	pseudouridine synthase activity
KFF03_RS11980	COG0500	methyltransferase
KFF03_RS11985	COG4106	trans-aconitate 2-methyltransferase activity
KFF03_RS11990	COG0583	DNA-binding transcription factor activity
KFF03_RS12050	COG1706	bacterial-type flagellum-dependent cell motility
KFF03_RS12055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KFF03_RS12060	COG4786	Flagellar basal body rod
KFF03_RS12065	COG4787	bacterial-type flagellum-dependent cell motility
KFF03_RS12075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KFF03_RS12085	COG1815	bacterial-type flagellum-dependent cell motility
KFF03_RS12095	COG0835	chemotaxis
KFF03_RS12095	COG0784	Response regulator, receiver
KFF03_RS12125	COG0033	Phosphoglucomutase
KFF03_RS12135	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS12140	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS12150	COG3239	Fatty acid desaturase
KFF03_RS12160	COG3300	MHYT domain
KFF03_RS12160	COG5001	Diguanylate cyclase
KFF03_RS12190	COG0784	Response regulator, receiver
KFF03_RS12190	COG5002	protein histidine kinase activity
KFF03_RS12190	COG2205	protein histidine kinase activity
KFF03_RS12200	COG0745	RESPONSE REGULATOR receiver
KFF03_RS12225	COG3220	belongs to the UPF0276 family
KFF03_RS12270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFF03_RS12275	COG1793	dna ligase
KFF03_RS12325	COG0583	DNA-binding transcription factor activity
KFF03_RS12335	COG0793	Belongs to the peptidase S41A family
KFF03_RS12350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KFF03_RS12370	COG0543	2 iron, 2 sulfur cluster binding
KFF03_RS12370	COG0633	Ferredoxin
KFF03_RS12380	COG1566	PFAM secretion protein HlyD family protein
KFF03_RS12385	COG3001	Fructosamine kinase
KFF03_RS12395	COG2837	iron assimilation
KFF03_RS12400	COG0277	FAD linked oxidase domain protein
KFF03_RS12410	COG1139	Iron-sulfur cluster binding protein
KFF03_RS12420	COG2186	Transcriptional regulator
KFF03_RS12430	COG0583	DNA-binding transcription factor activity
KFF03_RS12500	COG0210	DNA helicase
KFF03_RS12525	COG0009	L-threonylcarbamoyladenylate synthase
KFF03_RS12530	COG0613	PHP domain protein
KFF03_RS12535	COG2350	Protein conserved in bacteria
KFF03_RS12545	COG0719	Fe-S assembly protein
KFF03_RS12550	COG0396	ATPase activity
KFF03_RS12555	COG0719	Fe-S assembly protein
KFF03_RS12560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFF03_RS12605	COG1858	cytochrome C peroxidase
KFF03_RS12610	COG0393	Putative heavy-metal-binding
KFF03_RS12640	COG0492	ferredoxin-NADP+ reductase activity
KFF03_RS12705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KFF03_RS12710	COG0848	biopolymer transport protein
KFF03_RS12715	COG0811	peptide transport
KFF03_RS12720	COG0811	peptide transport
KFF03_RS12750	COG1132	(ABC) transporter
KFF03_RS12765	COG0579	oxidoreductase
KFF03_RS12780	COG0784	Response regulator, receiver
KFF03_RS12780	COG2205	protein histidine kinase activity
KFF03_RS12790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFF03_RS12830	COG1160	GTP binding
KFF03_RS12840	COG2976	Protein conserved in bacteria
KFF03_RS12845	COG0124	histidyl-tRNA synthetase
KFF03_RS12850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KFF03_RS12860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFF03_RS12865	COG0105	UTP biosynthetic process
KFF03_RS12870	COG1104	cysteine desulfurase activity
KFF03_RS12915	COG1131	(ABC) transporter
KFF03_RS12925	COG0742	ribosomal rna small subunit methyltransferase
KFF03_RS12930	COG1968	undecaprenyl-diphosphatase activity
KFF03_RS12935	COG1214	PFAM Peptidase M22, glycoprotease
KFF03_RS12945	COG0563	adenylate kinase activity
KFF03_RS12950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KFF03_RS12955	COG0137	argininosuccinate synthase activity
KFF03_RS12960	COG2885	chlorophyll binding
KFF03_RS12965	COG0418	dihydroorotase activity
KFF03_RS12970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFF03_RS12975	COG3112	Uncharacterised protein family (UPF0231)
KFF03_RS13025	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KFF03_RS13035	COG3630	sodium ion export across plasma membrane
KFF03_RS13040	COG0583	DNA-binding transcription factor activity
KFF03_RS13050	COG1454	alcohol dehydrogenase
KFF03_RS13055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF03_RS13060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFF03_RS13070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFF03_RS13075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KFF03_RS13090	COG0784	Response regulator, receiver
KFF03_RS13090	COG5002	protein histidine kinase activity
KFF03_RS13090	COG2198	Histidine kinase
KFF03_RS13110	COG1129	ABC transporter
KFF03_RS13130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFF03_RS13140	COG0084	hydrolase, TatD family'
KFF03_RS13145	COG0784	Response regulator, receiver
KFF03_RS13145	COG2205	protein histidine kinase activity
KFF03_RS13165	COG1366	Belongs to the anti-sigma-factor antagonist family
KFF03_RS13185	COG2814	Major facilitator Superfamily
KFF03_RS13190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KFF03_RS13195	COG1765	OsmC-like protein
KFF03_RS13205	COG0784	Response regulator, receiver
KFF03_RS13205	COG3437	response regulator, receiver
KFF03_RS13230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFF03_RS13235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KFF03_RS13255	COG0579	oxidoreductase
KFF03_RS13275	COG4772	TonB-dependent receptor
KFF03_RS13300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KFF03_RS13305	COG1322	Protein conserved in bacteria
KFF03_RS13310	COG0546	phosphoglycolate phosphatase activity
KFF03_RS13315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFF03_RS13345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KFF03_RS13350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KFF03_RS13370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFF03_RS13380	COG4536	flavin adenine dinucleotide binding
KFF03_RS13385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFF03_RS13385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFF03_RS13400	COG2067	long-chain fatty acid transport protein
KFF03_RS13410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KFF03_RS13420	COG1360	Flagellar Motor Protein
KFF03_RS13440	COG0688	phosphatidylethanolamine metabolic process
KFF03_RS13445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KFF03_RS13450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFF03_RS13455	COG1509	lysine 2,3-aminomutase activity
KFF03_RS13470	COG0560	Phosphoserine phosphatase
KFF03_RS13470	COG3830	Belongs to the UPF0237 family
KFF03_RS13510	COG0583	DNA-binding transcription factor activity
KFF03_RS13525	COG2197	response regulator
KFF03_RS13530	COG2814	Major facilitator Superfamily
KFF03_RS13535	COG0629	single-stranded DNA binding
KFF03_RS13540	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFF03_RS13550	COG0488	(ABC) transporter
KFF03_RS13565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFF03_RS13580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFF03_RS13605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFF03_RS13610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFF03_RS13610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFF03_RS13625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KFF03_RS13635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KFF03_RS13640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFF03_RS13645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF03_RS13655	COG3094	Invasion gene expression up-regulator, SirB
KFF03_RS13660	COG1490	D-aminoacyl-tRNA deacylase activity
KFF03_RS13670	COG3852	Histidine kinase
KFF03_RS13700	COG2165	general secretion pathway protein
KFF03_RS13715	COG1459	type II secretion system
KFF03_RS13720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFF03_RS13730	COG3267	Type II secretory pathway component ExeA
KFF03_RS13730	COG3409	Peptidoglycan-binding domain 1 protein
KFF03_RS13760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KFF03_RS13765	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KFF03_RS13770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFF03_RS13775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFF03_RS13780	COG4942	peptidase
KFF03_RS13785	COG0793	Belongs to the peptidase S41A family
KFF03_RS13790	COG2861	carbohydrate metabolic process
KFF03_RS13815	COG0436	Aminotransferase
KFF03_RS13820	COG2166	iron-sulfur cluster assembly
KFF03_RS13830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF03_RS13860	COG0126	phosphoglycerate kinase activity
KFF03_RS13870	COG0840	transmembrane signaling receptor activity
KFF03_RS13890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KFF03_RS13895	COG0527	aspartate kinase activity
KFF03_RS13900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFF03_RS13920	COG1252	NADH dehydrogenase
KFF03_RS13935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFF03_RS13965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KFF03_RS13970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KFF03_RS13975	COG0585	pseudouridine synthase activity
KFF03_RS13980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KFF03_RS13985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFF03_RS13990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KFF03_RS14000	COG0504	CTP synthase activity
KFF03_RS14005	COG1064	alcohol dehydrogenase
KFF03_RS14030	COG2914	Belongs to the UPF0125 (RnfH) family
KFF03_RS14040	COG0733	neurotransmitter:sodium symporter activity
KFF03_RS14045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFF03_RS14060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFF03_RS14080	COG0028	Belongs to the TPP enzyme family
KFF03_RS14085	COG0840	transmembrane signaling receptor activity
KFF03_RS14095	COG2249	NAD(P)H dehydrogenase (quinone) activity
KFF03_RS14105	COG0435	Glutathione S-transferase
KFF03_RS14110	COG0583	DNA-binding transcription factor activity
KFF03_RS14115	COG1741	Belongs to the pirin family
KFF03_RS14125	COG0583	DNA-binding transcription factor activity
KFF03_RS14130	COG3038	cytochrome b561
KFF03_RS14165	COG0439	Biotin carboxylase
KFF03_RS14180	COG3842	ATPase activity
KFF03_RS14230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KFF03_RS14235	COG0189	ligase activity
KFF03_RS14235	COG4067	protein conserved in archaea
KFF03_RS14240	COG0189	ligase activity
KFF03_RS14250	COG0583	DNA-binding transcription factor activity
KFF03_RS14260	COG2072	flavoprotein involved in K transport
KFF03_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
KFF03_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
KFF03_RS14300	COG1629	transport
KFF03_RS14300	COG4774	siderophore transport
KFF03_RS14310	COG0784	Response regulator, receiver
KFF03_RS14345	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KFF03_RS14365	COG1269	ATP hydrolysis coupled proton transport
KFF03_RS14390	COG0745	RESPONSE REGULATOR receiver
KFF03_RS14405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KFF03_RS14410	COG1492	cobalamin metabolic process
KFF03_RS14420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KFF03_RS14430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KFF03_RS14445	COG1940	carbohydrate kinase activity
KFF03_RS14450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KFF03_RS14455	COG3023	N-Acetylmuramoyl-L-alanine amidase
KFF03_RS14460	COG1115	amino acid carrier protein
KFF03_RS14495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KFF03_RS14500	COG0237	dephospho-CoA kinase activity
KFF03_RS14520	COG2199	diguanylate cyclase activity
KFF03_RS14520	COG2200	EAL domain
KFF03_RS14520	COG2203	Gaf domain
KFF03_RS14530	COG3706	GGDEF domain
KFF03_RS14535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KFF03_RS14540	COG2264	protein methyltransferase activity
KFF03_RS14550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFF03_RS14560	COG0138	bifunctional purine biosynthesis protein purh
KFF03_RS14565	COG0151	Belongs to the GarS family
KFF03_RS14570	COG2198	Histidine kinase
KFF03_RS14570	COG0784	Response regulator, receiver
KFF03_RS14570	COG5002	protein histidine kinase activity
KFF03_RS14580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KFF03_RS14595	COG0028	Belongs to the TPP enzyme family
KFF03_RS14625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFF03_RS14625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF03_RS14685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KFF03_RS14690	COG1047	Peptidyl-prolyl cis-trans
KFF03_RS14700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFF03_RS14705	COG0196	riboflavin kinase activity
KFF03_RS14710	COG0728	peptidoglycan biosynthetic process
KFF03_RS14715	COG0268	Binds directly to 16S ribosomal RNA
KFF03_RS14720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KFF03_RS14725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KFF03_RS14730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFF03_RS14735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFF03_RS14740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFF03_RS14745	COG0142	geranyltranstransferase activity
KFF03_RS14755	COG3118	belongs to the thioredoxin family
KFF03_RS14775	COG0583	DNA-binding transcription factor activity
KFF03_RS14795	COG1595	DNA-templated transcription, initiation
KFF03_RS14810	COG0584	glycerophosphoryl diester phosphodiesterase
KFF03_RS14835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFF03_RS14840	COG0321	lipoyl(octanoyl) transferase activity
KFF03_RS14845	COG2921	Belongs to the UPF0250 family
KFF03_RS14850	COG1686	Belongs to the peptidase S11 family
KFF03_RS14860	COG1785	Belongs to the alkaline phosphatase family
KFF03_RS14900	COG0463	Glycosyl transferase, family 2
KFF03_RS14900	COG1216	Glycosyl transferase, family 2
KFF03_RS14910	COG1216	Glycosyl transferase, family 2
KFF03_RS14910	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS14920	COG0529	Catalyzes the synthesis of activated sulfate
KFF03_RS14925	COG3273	potassium ion transport
KFF03_RS14925	COG0471	metal ion transport
KFF03_RS14930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFF03_RS14945	COG3754	Rhamnan synthesis protein F
KFF03_RS14950	COG1088	dTDP-glucose 4,6-dehydratase activity
KFF03_RS14990	COG3012	SEC-C Motif Domain Protein
KFF03_RS15020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KFF03_RS15025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFF03_RS15035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFF03_RS15040	COG0768	penicillin binding
KFF03_RS15045	COG0772	Belongs to the SEDS family
KFF03_RS15050	COG2951	lytic endotransglycosylase activity
KFF03_RS15055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KFF03_RS15070	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS15070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFF03_RS15110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KFF03_RS15115	COG0579	oxidoreductase
KFF03_RS15150	COG0438	transferase activity, transferring glycosyl groups
KFF03_RS15155	COG0671	phosphoesterase, PA-phosphatase related
KFF03_RS15170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KFF03_RS15175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFF03_RS15180	COG4558	Periplasmic binding protein
KFF03_RS15185	COG3720	iron ion transport
KFF03_RS15195	COG4771	TonB-dependent receptor
KFF03_RS15225	COG0523	cobalamin synthesis protein
KFF03_RS15230	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KFF03_RS15235	COG4181	ATPase activity
KFF03_RS15255	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KFF03_RS15270	COG0493	'glutamate synthase
KFF03_RS15275	COG0067	glutamate synthase
KFF03_RS15275	COG0069	glutamate synthase activity
KFF03_RS15275	COG0070	glutamate synthase
KFF03_RS15285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFF03_RS15290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFF03_RS15325	COG0277	FAD linked oxidase domain protein
KFF03_RS15330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF03_RS15335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KFF03_RS15340	COG0107	imidazoleglycerol-phosphate synthase activity
KFF03_RS15345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFF03_RS15350	COG0131	Imidazoleglycerol-phosphate dehydratase
KFF03_RS15370	COG1194	a g-specific adenine glycosylase
KFF03_RS15375	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KFF03_RS15385	COG3706	GGDEF domain
KFF03_RS15400	COG0514	ATP-dependent DNA helicase (RecQ)
KFF03_RS15410	COG0018	arginyl-trna synthetase
KFF03_RS15420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFF03_RS15430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KFF03_RS15435	COG1561	YicC-like family, N-terminal region
KFF03_RS15450	COG0789	Transcriptional regulator
KFF03_RS15455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KFF03_RS15460	COG1687	branched-chain amino acid
KFF03_RS15470	COG0129	dihydroxy-acid dehydratase activity
KFF03_RS15500	COG1671	Belongs to the UPF0178 family
KFF03_RS15520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFF03_RS15535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF03_RS15540	COG0702	epimerase
KFF03_RS15550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFF03_RS15555	COG4953	penicillin-binding protein 1C
KFF03_RS15560	COG2373	Large extracellular alpha-helical protein
KFF03_RS15570	COG2095	MarC family integral membrane protein
KFF03_RS15635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFF03_RS15640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFF03_RS15645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KFF03_RS15660	COG0519	Catalyzes the synthesis of GMP from XMP
KFF03_RS15665	COG0330	HflC and HflK could
KFF03_RS15670	COG0330	HflC and HflK could
KFF03_RS15675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFF03_RS15685	COG1923	regulation of RNA biosynthetic process
KFF03_RS15690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFF03_RS15695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFF03_RS15700	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFF03_RS15705	COG0802	atpase or kinase
KFF03_RS15710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFF03_RS15710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFF03_RS15720	COG1881	PFAM PEBP family protein
KFF03_RS15730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFF03_RS15740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KFF03_RS15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF03_RS15780	COG1238	metal cluster binding
KFF03_RS15790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KFF03_RS15795	COG0840	transmembrane signaling receptor activity
KFF03_RS15800	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KFF03_RS15820	COG1301	dicarboxylic acid transport
KFF03_RS15845	COG1773	rubredoxin
KFF03_RS15855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KFF03_RS15880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFF03_RS15895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFF03_RS15925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFF03_RS15930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFF03_RS15935	COG0254	rRNA binding
KFF03_RS15940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFF03_RS15950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KFF03_RS15970	COG1607	acyl-coa hydrolase
KFF03_RS15975	COG0121	glutamine amidotransferase
KFF03_RS15990	COG0640	Transcriptional regulator
KFF03_RS15995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFF03_RS16000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KFF03_RS16005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KFF03_RS16010	COG0515	serine threonine protein kinase
KFF03_RS16025	COG3307	-O-antigen
KFF03_RS16030	COG3562	capsule polysaccharide
KFF03_RS16045	COG2201	protein-glutamate methylesterase activity
KFF03_RS16050	COG0643	Histidine kinase
KFF03_RS16050	COG2198	Histidine kinase
KFF03_RS16050	COG0784	Response regulator, receiver
KFF03_RS16050	COG0643	Histidine kinase
KFF03_RS16050	COG2198	Histidine kinase
KFF03_RS16050	COG0784	Response regulator, receiver
KFF03_RS16055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KFF03_RS16090	COG1678	Uncharacterized ACR, COG1678
KFF03_RS16105	COG0540	Belongs to the ATCase OTCase family
KFF03_RS16135	COG0019	diaminopimelate decarboxylase activity
KFF03_RS16140	COG1082	Xylose isomerase domain protein TIM barrel
KFF03_RS16180	COG1166	arginine decarboxylase activity
KFF03_RS16195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF03_RS16200	COG2375	cellular response to nickel ion
KFF03_RS16230	COG1011	Hydrolase
KFF03_RS16250	COG1166	arginine decarboxylase activity
KFF03_RS16255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KFF03_RS16280	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS16330	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KFF03_RS16345	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KFF03_RS16355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFF03_RS16355	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
KFF03_RS16370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFF03_RS16375	COG0154	amidase activity
KFF03_RS16380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFF03_RS16385	COG1077	Cell shape determining protein MreB Mrl
KFF03_RS16395	COG1792	Involved in formation and maintenance of cell shape
KFF03_RS16405	COG0424	maF-like protein
KFF03_RS16410	COG1530	ribonuclease E activity
KFF03_RS16420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF03_RS16425	COG0668	transmembrane transport
KFF03_RS16430	COG0318	PFAM AMP-dependent synthetase and ligase
KFF03_RS16455	COG0194	GDP metabolic process
KFF03_RS16460	COG1758	RNA polymerase activity
KFF03_RS16465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFF03_RS16505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFF03_RS16510	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS16520	COG4770	biotin carboxylase activity
KFF03_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
KFF03_RS16555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF03_RS16560	COG1129	ABC transporter
KFF03_RS16560	COG0842	Transport permease protein
KFF03_RS16565	COG0842	Transport permease protein
KFF03_RS16580	COG3437	response regulator, receiver
KFF03_RS16600	COG3118	belongs to the thioredoxin family
KFF03_RS16610	COG0829	nickel cation binding
KFF03_RS16615	COG0831	urea catabolic process
KFF03_RS16620	COG0832	Belongs to the urease beta subunit family
KFF03_RS16625	COG0804	urea catabolic process
KFF03_RS16630	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KFF03_RS16635	COG0830	nickel cation binding
KFF03_RS16640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFF03_RS16665	COG0411	ABC transporter
KFF03_RS16685	COG0347	Belongs to the P(II) protein family
KFF03_RS16690	COG0004	ammonium transporteR
KFF03_RS16705	COG2885	chlorophyll binding
KFF03_RS16710	COG2873	o-acetylhomoserine
KFF03_RS16715	COG0784	Response regulator, receiver
KFF03_RS16715	COG5002	protein histidine kinase activity
KFF03_RS16725	COG2205	protein histidine kinase activity
KFF03_RS16725	COG0784	Response regulator, receiver
KFF03_RS16730	COG2197	response regulator
KFF03_RS16740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF03_RS16750	COG5492	domain, Protein
KFF03_RS16750	COG4932	domain protein
KFF03_RS16760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFF03_RS16765	COG3706	GGDEF domain
KFF03_RS16765	COG4251	negative regulation of phosphorylation
KFF03_RS16765	COG5001	Diguanylate cyclase
KFF03_RS16765	COG2203	Gaf domain
KFF03_RS16775	COG2050	protein possibly involved in aromatic compounds catabolism
KFF03_RS16800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF03_RS16805	COG0210	DNA helicase
KFF03_RS16825	COG0534	Mate efflux family protein
KFF03_RS16855	COG2814	Major facilitator Superfamily
KFF03_RS16865	COG2989	Protein conserved in bacteria
KFF03_RS16870	COG3108	Peptidase M15
KFF03_RS16880	COG0494	nUDIX hydrolase
KFF03_RS16900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFF03_RS16910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFF03_RS16915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFF03_RS16920	COG0006	proline dipeptidase activity
KFF03_RS16945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFF03_RS16965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KFF03_RS16980	COG1331	Highly conserved protein containing a thioredoxin domain
KFF03_RS17010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFF03_RS17020	COG0730	response to heat
KFF03_RS17030	COG3621	Patatin-like phospholipase
KFF03_RS17045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KFF03_RS17075	COG1704	LemA family
KFF03_RS17080	COG0501	Belongs to the peptidase M48B family
KFF03_RS17085	COG1132	(ABC) transporter
KFF03_RS17090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFF03_RS17095	COG0746	molybdenum cofactor guanylyltransferase activity
KFF03_RS17100	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFF03_RS17105	COG0315	cyclic pyranopterin monophosphate synthase activity
KFF03_RS17110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KFF03_RS17115	COG0314	molybdopterin synthase activity
KFF03_RS17120	COG1024	Enoyl-CoA hydratase
KFF03_RS17125	COG1960	acyl-CoA dehydrogenase activity
KFF03_RS17130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFF03_RS17160	COG1349	DNA-binding transcription factor activity
KFF03_RS17165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFF03_RS17175	COG0181	hydroxymethylbilane synthase activity
KFF03_RS17185	COG2959	enzyme of heme biosynthesis
KFF03_RS17200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFF03_RS17200	COG0543	2 iron, 2 sulfur cluster binding
KFF03_RS17210	COG2363	Small membrane protein
KFF03_RS17215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFF03_RS17250	COG3712	iron ion homeostasis
KFF03_RS17255	COG1595	DNA-templated transcription, initiation
KFF03_RS17270	COG0848	biopolymer transport protein
KFF03_RS17285	COG0488	(ABC) transporter
KFF03_RS17320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KFF03_RS17330	COG2918	glutathione biosynthetic process
KFF03_RS17335	COG2183	response to ionizing radiation
KFF03_RS17345	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFF03_RS17350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFF03_RS17365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFF03_RS17370	COG2198	Histidine kinase
KFF03_RS17370	COG0784	Response regulator, receiver
KFF03_RS17370	COG2205	protein histidine kinase activity
KFF03_RS17375	COG1011	Hydrolase
KFF03_RS17380	COG0494	nUDIX hydrolase
KFF03_RS17405	COG0628	permease
KFF03_RS17410	COG0745	RESPONSE REGULATOR receiver
KFF03_RS17415	COG2205	protein histidine kinase activity
KFF03_RS17420	COG0281	malic enzyme
KFF03_RS17430	COG1217	gtp-binding protein TYPA
KFF03_RS17445	COG0408	coproporphyrinogen oxidase activity
KFF03_RS17450	COG0009	L-threonylcarbamoyladenylate synthase
KFF03_RS17455	COG0758	DNA mediated transformation
KFF03_RS17465	COG0242	peptide deformylase activity
KFF03_RS17470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFF03_RS17480	COG0569	domain protein
KFF03_RS17485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFF03_RS17500	COG2205	protein histidine kinase activity
KFF03_RS17505	COG0752	glycyl-tRNA synthetase alpha subunit
KFF03_RS17510	COG0751	glycine-tRNA ligase activity
KFF03_RS17530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFF03_RS17540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFF03_RS17550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFF03_RS17560	COG0356	it plays a direct role in the translocation of protons across the membrane
KFF03_RS17570	COG1475	DNA binding
KFF03_RS17575	COG1192	Involved in chromosome partitioning
KFF03_RS17580	COG0357	Ribosomal RNA small subunit methyltransferase G
KFF03_RS17585	COG1301	dicarboxylic acid transport
KFF03_RS17600	COG3300	MHYT domain
KFF03_RS17600	COG5001	Diguanylate cyclase
KFF03_RS17605	COG0445	tRNA wobble uridine modification
KFF03_RS17630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFF03_RS17635	COG0706	membrane insertase activity
KFF03_RS17650	COG0230	Belongs to the bacterial ribosomal protein bL34 family