locus-tag	class	description
C0V70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0V70_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0V70_RS00020	COG0187	DNA topoisomerase II activity
C0V70_RS00065	COG0356	it plays a direct role in the translocation of protons across the membrane
C0V70_RS00070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0V70_RS00090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0V70_RS00095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0V70_RS00110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0V70_RS00115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS00120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0V70_RS00125	COG0839	Belongs to the complex I subunit 6 family
C0V70_RS00130	COG0713	ATP synthesis coupled electron transport
C0V70_RS00140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS00145	COG1007	ATP synthesis coupled electron transport
C0V70_RS00150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS00155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0V70_RS00160	COG0839	Belongs to the complex I subunit 6 family
C0V70_RS00165	COG0713	ATP synthesis coupled electron transport
C0V70_RS00170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0V70_RS00180	COG1007	ATP synthesis coupled electron transport
C0V70_RS00220	COG0745	RESPONSE REGULATOR receiver
C0V70_RS00240	COG0724	RNA recognition motif
C0V70_RS00245	COG0513	Belongs to the DEAD box helicase family
C0V70_RS00260	COG0714	Associated with various cellular activities
C0V70_RS00285	COG0590	tRNA wobble adenosine to inosine editing
C0V70_RS00295	COG1011	Hydrolase
C0V70_RS00300	COG0596	Alpha beta hydrolase
C0V70_RS00315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0V70_RS00320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0V70_RS00330	COG1100	Small GTP-binding protein
C0V70_RS00340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C0V70_RS00345	COG0275	rRNA processing
C0V70_RS00360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0V70_RS00365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0V70_RS00370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0V70_RS00375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0V70_RS00380	COG0772	Belongs to the SEDS family
C0V70_RS00385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0V70_RS00425	COG0572	uridine kinase
C0V70_RS00435	COG2264	protein methyltransferase activity
C0V70_RS00450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0V70_RS00450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C0V70_RS00455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS00460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS00465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS00480	COG0497	DNA recombination
C0V70_RS00485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0V70_RS00490	COG0784	Response regulator, receiver
C0V70_RS00490	COG2198	Histidine kinase
C0V70_RS00490	COG5002	protein histidine kinase activity
C0V70_RS00495	COG4191	Histidine kinase
C0V70_RS00525	COG1516	flagellar protein fliS
C0V70_RS00545	COG1218	3'(2'),5'-bisphosphate nucleotidase
C0V70_RS00550	COG2204	response regulator
C0V70_RS00560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0V70_RS00575	COG1193	negative regulation of DNA recombination
C0V70_RS00600	COG0714	Associated with various cellular activities
C0V70_RS00615	COG2304	oxidoreductase activity
C0V70_RS00630	COG0196	riboflavin kinase activity
C0V70_RS00635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0V70_RS00640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0V70_RS00650	COG1459	type II secretion system
C0V70_RS00655	COG4968	Prepilin-type N-terminal cleavage methylation domain
C0V70_RS00665	COG1131	(ABC) transporter
C0V70_RS00675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0V70_RS00715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0V70_RS00735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0V70_RS00740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0V70_RS00745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0V70_RS00765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0V70_RS00770	COG1758	RNA polymerase activity
C0V70_RS00800	COG4166	transmembrane transport
C0V70_RS00805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0V70_RS00825	COG2137	regulation of response to DNA damage stimulus
C0V70_RS00830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0V70_RS00850	COG0596	Alpha beta hydrolase
C0V70_RS00875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0V70_RS00880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0V70_RS00910	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0V70_RS00920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS00925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS01015	COG2201	protein-glutamate methylesterase activity
C0V70_RS01020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0V70_RS01035	COG0210	DNA helicase
C0V70_RS01045	COG0038	chloride channel
C0V70_RS01065	COG0248	Ppx GppA phosphatase
C0V70_RS01110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0V70_RS01125	COG1845	cytochrome c oxidase, subunit III
C0V70_RS01135	COG2322	membrane
C0V70_RS01150	COG0109	protoheme IX farnesyltransferase activity
C0V70_RS01160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0V70_RS01165	COG1845	cytochrome c oxidase, subunit III
C0V70_RS01195	COG3384	dioxygenase
C0V70_RS01235	COG1674	ftsk spoiiie
C0V70_RS01240	COG0052	Belongs to the universal ribosomal protein uS2 family
C0V70_RS01245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0V70_RS01250	COG0528	UMP kinase activity
C0V70_RS01255	COG0233	cytoplasmic translational termination
C0V70_RS01260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0V70_RS01265	COG4589	Belongs to the CDS family
C0V70_RS01270	COG0750	zinc metalloprotease
C0V70_RS01285	COG1183	phosphatidylcholine synthase activity
C0V70_RS01295	COG0101	tRNA pseudouridine synthase activity
C0V70_RS01305	COG0525	valine-tRNA ligase activity
C0V70_RS01330	COG0247	lactate metabolic process
C0V70_RS01330	COG2181	nitrate reductase activity
C0V70_RS01340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0V70_RS01385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0V70_RS01390	COG3118	belongs to the thioredoxin family
C0V70_RS01410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0V70_RS01415	COG0459	protein refolding
C0V70_RS01475	COG4174	ABC transporter (Permease)
C0V70_RS01480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0V70_RS01485	COG4206	TonB-dependent receptor
C0V70_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0V70_RS01500	COG1120	ATPase activity
C0V70_RS01505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0V70_RS01510	COG0688	phosphatidylethanolamine metabolic process
C0V70_RS01540	COG0646	methionine synthase
C0V70_RS01540	COG1410	methionine synthase
C0V70_RS01545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0V70_RS01590	COG2089	acid synthase
C0V70_RS01600	COG1086	Polysaccharide biosynthesis protein
C0V70_RS01605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0V70_RS01615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0V70_RS01620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0V70_RS01630	COG2089	acid synthase
C0V70_RS01640	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C0V70_RS01645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0V70_RS01675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0V70_RS01685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0V70_RS01710	COG1215	transferase activity, transferring glycosyl groups
C0V70_RS01730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0V70_RS01760	COG0840	transmembrane signaling receptor activity
C0V70_RS01800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0V70_RS01815	COG4191	Histidine kinase
C0V70_RS01820	COG4191	Histidine kinase
C0V70_RS01830	COG0358	DNA primase activity
C0V70_RS01830	COG0305	Participates in initiation and elongation during chromosome replication
C0V70_RS01835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0V70_RS01865	COG1051	belongs to the nudix hydrolase family
C0V70_RS01870	COG1994	Peptidase M50
C0V70_RS01875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0V70_RS01880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0V70_RS01885	COG1187	pseudouridine synthase activity
C0V70_RS01900	COG1819	glycosyl
C0V70_RS02060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0V70_RS02070	COG2217	Heavy metal translocating P-type atpase
C0V70_RS02085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0V70_RS02090	COG0799	negative regulation of ribosome biogenesis
C0V70_RS02095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0V70_RS02100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0V70_RS02105	COG3743	rRNA binding
C0V70_RS02105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0V70_RS02115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0V70_RS02125	COG0741	lytic transglycosylase activity
C0V70_RS02125	COG1388	LysM domain
C0V70_RS02155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0V70_RS02180	COG0481	GTPase activity
C0V70_RS02210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0V70_RS02235	COG0463	Glycosyl transferase, family 2
C0V70_RS02280	COG1132	(ABC) transporter
C0V70_RS02290	COG2192	nodulation
C0V70_RS02300	COG0423	glycine-tRNA ligase activity
C0V70_RS02305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0V70_RS02305	COG0574	Belongs to the PEP-utilizing enzyme family
C0V70_RS02350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0V70_RS02360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0V70_RS02395	COG1127	ABC transporter
C0V70_RS02400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0V70_RS02415	COG2204	response regulator
C0V70_RS02430	COG1677	Flagellar hook-basal body complex protein FliE
C0V70_RS02435	COG1766	The M ring may be actively involved in energy transduction
C0V70_RS02440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0V70_RS02450	COG1157	protein secretion by the type III secretion system
C0V70_RS02470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0V70_RS02525	COG0772	Belongs to the SEDS family
C0V70_RS02530	COG1846	Transcriptional regulator
C0V70_RS02550	COG1078	dGTPase activity
C0V70_RS02580	COG0517	IMP dehydrogenase activity
C0V70_RS02605	COG3481	metal-dependent phosphohydrolase, HD sub domain
C0V70_RS02620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0V70_RS02625	COG0126	phosphoglycerate kinase activity
C0V70_RS02655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0V70_RS02675	COG1104	cysteine desulfurase activity
C0V70_RS02690	COG1404	Belongs to the peptidase S8 family
C0V70_RS02695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0V70_RS02710	COG0084	hydrolase, TatD family'
C0V70_RS02715	COG0745	RESPONSE REGULATOR receiver
C0V70_RS02750	COG0745	RESPONSE REGULATOR receiver
C0V70_RS02760	COG1496	oxidoreductase activity
C0V70_RS02765	COG0564	pseudouridine synthase activity
C0V70_RS02770	COG0484	heat shock protein binding
C0V70_RS02785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0V70_RS02790	COG1482	cell wall glycoprotein biosynthetic process
C0V70_RS02805	COG2027	D-alanyl-D-alanine carboxypeptidase
C0V70_RS02810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C0V70_RS02825	COG1053	succinate dehydrogenase
C0V70_RS02830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0V70_RS02835	COG1418	mRNA catabolic process
C0V70_RS02845	COG0288	reversible hydration of carbon dioxide
C0V70_RS02860	COG0724	RNA recognition motif
C0V70_RS02865	COG0318	PFAM AMP-dependent synthetase and ligase
C0V70_RS02880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0V70_RS02950	COG0495	leucyl-tRNA aminoacylation
C0V70_RS02955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0V70_RS02960	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0V70_RS02980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0V70_RS02990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0V70_RS03000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0V70_RS03005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0V70_RS03035	COG0517	IMP dehydrogenase activity
C0V70_RS03035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0V70_RS03040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0V70_RS03050	COG1404	Belongs to the peptidase S8 family
C0V70_RS03075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0V70_RS03090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0V70_RS03095	COG3872	metal-dependent enzyme
C0V70_RS03100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0V70_RS03105	COG2890	protein-(glutamine-N5) methyltransferase activity
C0V70_RS03110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0V70_RS03115	COG0537	adenosine 5'-monophosphoramidase activity
C0V70_RS03140	COG0488	(ABC) transporter
C0V70_RS03155	COG1393	Belongs to the ArsC family
C0V70_RS03175	COG1733	regulation of RNA biosynthetic process
C0V70_RS03185	COG1607	acyl-coa hydrolase
C0V70_RS03190	COG0840	transmembrane signaling receptor activity
C0V70_RS03195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0V70_RS03200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C0V70_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS03215	COG0583	DNA-binding transcription factor activity
C0V70_RS03240	COG4191	Histidine kinase
C0V70_RS03265	COG1162	GTPase activity
C0V70_RS03285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0V70_RS03295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0V70_RS03295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C0V70_RS03330	COG0538	isocitrate dehydrogenase activity
C0V70_RS03365	COG1404	Belongs to the peptidase S8 family
C0V70_RS03380	COG0359	binds to the 23S rRNA
C0V70_RS03385	COG0305	Participates in initiation and elongation during chromosome replication
C0V70_RS03415	COG2917	probably involved in intracellular septation
C0V70_RS03430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C0V70_RS03450	COG2226	methyltransferase
C0V70_RS03455	COG3158	transport of potassium into the cell
C0V70_RS03465	COG3340	Belongs to the peptidase S51 family
C0V70_RS03485	COG0417	DNA replication proofreading
C0V70_RS03520	COG2205	protein histidine kinase activity
C0V70_RS03520	COG2198	Histidine kinase
C0V70_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0V70_RS03520	COG0784	Response regulator, receiver
C0V70_RS03530	COG0783	Belongs to the Dps family
C0V70_RS03540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0V70_RS03550	COG1137	ATPase activity
C0V70_RS03555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C0V70_RS03575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0V70_RS03585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0V70_RS03600	COG0189	ligase activity
C0V70_RS03605	COG0840	transmembrane signaling receptor activity
C0V70_RS03670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0V70_RS03700	COG0450	alkyl hydroperoxide reductase
C0V70_RS03705	COG0740	serine-type endopeptidase activity
C0V70_RS03710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0V70_RS03715	COG0840	transmembrane signaling receptor activity
C0V70_RS03730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0V70_RS03760	COG2095	MarC family integral membrane protein
C0V70_RS03780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C0V70_RS03785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C0V70_RS03795	COG1530	ribonuclease E activity
C0V70_RS03805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0V70_RS03810	COG0789	Transcriptional regulator
C0V70_RS03830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0V70_RS03840	COG0424	maF-like protein
C0V70_RS03865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0V70_RS03865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C0V70_RS03885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0V70_RS03910	COG1131	(ABC) transporter
C0V70_RS03940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C0V70_RS03960	COG1595	DNA-templated transcription, initiation
C0V70_RS03990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0V70_RS04000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0V70_RS04005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0V70_RS04030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C0V70_RS04040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C0V70_RS04045	COG2205	protein histidine kinase activity
C0V70_RS04050	COG0745	RESPONSE REGULATOR receiver
C0V70_RS04070	COG2885	chlorophyll binding
C0V70_RS04105	COG1396	sequence-specific DNA binding
C0V70_RS04115	COG4221	oxidoreductase activity
C0V70_RS04125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C0V70_RS04130	COG3093	addiction module antidote protein HigA
C0V70_RS04140	COG1164	Oligoendopeptidase f
C0V70_RS04170	COG2226	methyltransferase
C0V70_RS04180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0V70_RS04240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0V70_RS04245	COG0732	type I restriction modification DNA specificity domain
C0V70_RS04325	COG0577	efflux transmembrane transporter activity
C0V70_RS04335	COG0840	transmembrane signaling receptor activity
C0V70_RS04365	COG0583	DNA-binding transcription factor activity
C0V70_RS04395	COG0840	transmembrane signaling receptor activity
C0V70_RS04400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0V70_RS04445	COG0840	transmembrane signaling receptor activity
C0V70_RS04450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0V70_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS04490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0V70_RS04550	COG0471	metal ion transport
C0V70_RS04570	COG0784	Response regulator, receiver
C0V70_RS04570	COG2205	protein histidine kinase activity
C0V70_RS04605	COG0747	negative chemotaxis
C0V70_RS04655	COG3620	sequence-specific DNA binding
C0V70_RS04690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0V70_RS04695	COG1881	PFAM PEBP family protein
C0V70_RS04720	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C0V70_RS04730	COG0071	Belongs to the small heat shock protein (HSP20) family
C0V70_RS04755	COG0519	Catalyzes the synthesis of GMP from XMP
C0V70_RS04755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0V70_RS04770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0V70_RS04775	COG0840	transmembrane signaling receptor activity
C0V70_RS04810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0V70_RS04830	COG1064	alcohol dehydrogenase
C0V70_RS04885	COG1061	Type III restriction enzyme res subunit
C0V70_RS04910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0V70_RS04950	COG4555	ABC transporter
C0V70_RS04980	COG0484	heat shock protein binding
C0V70_RS05020	COG3568	Endonuclease Exonuclease Phosphatase
C0V70_RS05030	COG4085	toxin activity
C0V70_RS05030	COG1525	nuclease
C0V70_RS05030	COG0737	Belongs to the 5'-nucleotidase family
C0V70_RS05050	COG1027	Aspartate ammonia-lyase
C0V70_RS05060	COG0531	amino acid
C0V70_RS05080	COG0402	S-adenosylhomocysteine deaminase activity
C0V70_RS05095	COG0542	response to heat
C0V70_RS05100	COG3530	Putative quorum-sensing-regulated virulence factor
C0V70_RS05105	COG0514	ATP-dependent DNA helicase (RecQ)
C0V70_RS05115	COG3135	benzoate transporter
C0V70_RS05125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0V70_RS05140	COG2267	carboxylic ester hydrolase activity
C0V70_RS05170	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C0V70_RS05185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0V70_RS05190	COG1940	carbohydrate kinase activity
C0V70_RS05195	COG2182	Extracellular solute-binding protein
C0V70_RS05200	COG1523	belongs to the glycosyl hydrolase 13 family
C0V70_RS05215	COG1175	transmembrane transport
C0V70_RS05220	COG3833	ABC-type maltose transport systems, permease component
C0V70_RS05225	COG3842	ATPase activity
C0V70_RS05255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0V70_RS05275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0V70_RS05320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C0V70_RS05360	COG2239	Acts as a magnesium transporter
C0V70_RS05380	COG4335	DNA alkylation repair
C0V70_RS05390	COG2133	pyrroloquinoline quinone binding
C0V70_RS05395	COG0076	glutamate decarboxylase activity
C0V70_RS05400	COG1104	cysteine desulfurase activity
C0V70_RS05410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0V70_RS05415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C0V70_RS05425	COG1032	radical SAM domain protein
C0V70_RS05450	COG0398	Pfam SNARE associated Golgi protein
C0V70_RS05460	COG2814	Major facilitator Superfamily
C0V70_RS05465	COG1902	pentaerythritol trinitrate reductase activity
C0V70_RS05470	COG0583	DNA-binding transcription factor activity
C0V70_RS05495	COG4191	Histidine kinase
C0V70_RS05500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0V70_RS05510	COG0084	hydrolase, TatD family'
C0V70_RS05515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C0V70_RS05525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS05525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS05530	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS05535	COG1322	Protein conserved in bacteria
C0V70_RS05580	COG0625	glutathione transferase activity
C0V70_RS05585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0V70_RS05630	COG2204	response regulator
C0V70_RS05665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0V70_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS05680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0V70_RS05695	COG1858	cytochrome C peroxidase
C0V70_RS05705	COG1666	GTP binding
C0V70_RS05745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0V70_RS05870	COG1937	Protein conserved in bacteria
C0V70_RS05875	COG1937	Protein conserved in bacteria
C0V70_RS05905	COG2217	Heavy metal translocating P-type atpase
C0V70_RS05960	COG2801	Transposase and inactivated derivatives
C0V70_RS05970	COG1937	Protein conserved in bacteria
C0V70_RS05975	COG2132	Multicopper oxidase
C0V70_RS06015	COG2801	Transposase and inactivated derivatives
C0V70_RS06085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0V70_RS06120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0V70_RS06120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0V70_RS06150	COG1408	metallophosphoesterase
C0V70_RS06155	COG2801	Transposase and inactivated derivatives
C0V70_RS06195	COG0724	RNA recognition motif
C0V70_RS06210	COG1944	ATP diphosphatase activity
C0V70_RS06215	COG3040	lipid binding
C0V70_RS06230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0V70_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS06255	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C0V70_RS06275	COG4191	Histidine kinase
C0V70_RS06285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0V70_RS06285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0V70_RS06290	COG0783	Belongs to the Dps family
C0V70_RS06305	COG1902	pentaerythritol trinitrate reductase activity
C0V70_RS06315	COG0583	DNA-binding transcription factor activity
C0V70_RS06325	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C0V70_RS06330	COG2204	response regulator
C0V70_RS06380	COG0668	transmembrane transport
C0V70_RS06390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0V70_RS06410	COG0348	domain, Protein
C0V70_RS06425	COG3278	Belongs to the heme-copper respiratory oxidase family
C0V70_RS06450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0V70_RS06480	COG3634	alkyl hydroperoxide reductase activity
C0V70_RS06490	COG0726	polysaccharide deacetylase
C0V70_RS06545	COG0840	transmembrane signaling receptor activity
C0V70_RS06560	COG2885	chlorophyll binding
C0V70_RS06570	COG0861	Integral membrane protein TerC family
C0V70_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS06630	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C0V70_RS06635	COG0577	efflux transmembrane transporter activity
C0V70_RS06635	COG1136	(ABC) transporter
C0V70_RS06650	COG2814	Major facilitator Superfamily
C0V70_RS06670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0V70_RS06680	COG0840	transmembrane signaling receptor activity
C0V70_RS06695	COG0840	transmembrane signaling receptor activity
C0V70_RS06715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS06720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS06725	COG0649	NAD binding
C0V70_RS06730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS06745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0V70_RS06760	COG0488	(ABC) transporter
C0V70_RS06765	COG0527	aspartate kinase activity
C0V70_RS06770	COG4962	Type ii secretion system protein e
C0V70_RS06840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0V70_RS06845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0V70_RS06850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0V70_RS06855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0V70_RS06860	COG0151	Belongs to the GarS family
C0V70_RS06865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0V70_RS06870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0V70_RS06875	COG0047	phosphoribosylformylglycinamidine synthase activity
C0V70_RS06880	COG0138	bifunctional purine biosynthesis protein purh
C0V70_RS06895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0V70_RS06920	COG0504	CTP synthase activity
C0V70_RS06925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C0V70_RS06940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0V70_RS06945	COG1397	ADP-ribosylglycohydrolase
C0V70_RS06955	COG4191	Histidine kinase
C0V70_RS06975	COG0516	GMP reductase activity
C0V70_RS06975	COG0517	IMP dehydrogenase activity
C0V70_RS06980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0V70_RS06980	COG0519	Catalyzes the synthesis of GMP from XMP
C0V70_RS07020	COG0167	dihydroorotate dehydrogenase activity
C0V70_RS07035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0V70_RS07040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0V70_RS07055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0V70_RS07060	COG0643	Histidine kinase
C0V70_RS07060	COG2198	Histidine kinase
C0V70_RS07070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0V70_RS07080	COG0745	RESPONSE REGULATOR receiver
C0V70_RS07090	COG2274	protein secretion by the type I secretion system
C0V70_RS07095	COG1132	(ABC) transporter
C0V70_RS07100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0V70_RS07100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0V70_RS07110	COG0469	pyruvate kinase activity
C0V70_RS07115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C0V70_RS07120	COG1136	(ABC) transporter
C0V70_RS07120	COG0577	efflux transmembrane transporter activity
C0V70_RS07125	COG1136	(ABC) transporter
C0V70_RS07145	COG0840	transmembrane signaling receptor activity
C0V70_RS07150	COG0475	glutathione-regulated potassium exporter activity
C0V70_RS07185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0V70_RS07200	COG1393	Belongs to the ArsC family
C0V70_RS07225	COG1872	DUF167
C0V70_RS07250	COG1846	Transcriptional regulator
C0V70_RS07255	COG1764	response to oxidative stress
C0V70_RS07265	COG5002	protein histidine kinase activity
C0V70_RS07270	COG0745	RESPONSE REGULATOR receiver
C0V70_RS07275	COG2885	chlorophyll binding
C0V70_RS07285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0V70_RS07320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0V70_RS07345	COG0308	aminopeptidase N
C0V70_RS07365	COG0191	fructose-bisphosphate aldolase activity
C0V70_RS07370	COG0022	dehydrogenase e1 component
C0V70_RS07380	COG0321	lipoyl(octanoyl) transferase activity
C0V70_RS07385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0V70_RS07425	COG0408	coproporphyrinogen oxidase activity
C0V70_RS07445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0V70_RS07450	COG0719	Fe-S assembly protein
C0V70_RS07455	COG0396	ATPase activity
C0V70_RS07460	COG0719	Fe-S assembly protein
C0V70_RS07500	COG0187	DNA topoisomerase II activity
C0V70_RS07505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0V70_RS07570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0V70_RS07585	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS07600	COG0583	DNA-binding transcription factor activity
C0V70_RS07610	COG0750	zinc metalloprotease
C0V70_RS07635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0V70_RS07640	COG0006	proline dipeptidase activity
C0V70_RS07665	COG2226	methyltransferase
C0V70_RS07675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0V70_RS07680	COG3291	Pkd domain containing protein
C0V70_RS07700	COG2801	Transposase and inactivated derivatives
C0V70_RS07740	COG0513	Belongs to the DEAD box helicase family
C0V70_RS07760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0V70_RS07775	COG0602	queuosine metabolic process
C0V70_RS07800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0V70_RS07840	COG0574	Belongs to the PEP-utilizing enzyme family
C0V70_RS07840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0V70_RS07845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0V70_RS07850	COG1053	succinate dehydrogenase
C0V70_RS07860	COG0189	ligase activity
C0V70_RS07860	COG4067	protein conserved in archaea
C0V70_RS07865	COG0189	ligase activity
C0V70_RS07875	COG2205	protein histidine kinase activity
C0V70_RS07880	COG0745	RESPONSE REGULATOR receiver
C0V70_RS07885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0V70_RS07885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0V70_RS07915	COG4191	Histidine kinase
C0V70_RS07920	COG0010	Belongs to the arginase family
C0V70_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0V70_RS07935	COG0045	succinate-CoA ligase (ADP-forming) activity
C0V70_RS07940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0V70_RS07945	COG0105	UTP biosynthetic process
C0V70_RS07975	COG0215	cysteine-tRNA ligase activity
C0V70_RS07985	COG0778	Nitroreductase
C0V70_RS07995	COG2855	membrane
C0V70_RS08000	COG0019	diaminopimelate decarboxylase activity
C0V70_RS08005	COG0556	nucleotide-excision repair
C0V70_RS08065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0V70_RS08090	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS08110	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0V70_RS08120	COG1024	Enoyl-CoA hydratase
C0V70_RS08125	COG1024	Enoyl-CoA hydratase
C0V70_RS08225	COG3852	Histidine kinase
C0V70_RS08245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0V70_RS08250	COG1024	Enoyl-CoA hydratase
C0V70_RS08255	COG4770	biotin carboxylase activity
C0V70_RS08265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0V70_RS08275	COG1024	Enoyl-CoA hydratase
C0V70_RS08295	COG0210	DNA helicase
C0V70_RS08305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0V70_RS08355	COG1546	Belongs to the CinA family
C0V70_RS08355	COG1058	Belongs to the CinA family
C0V70_RS08360	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C0V70_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS08385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0V70_RS08405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0V70_RS08410	COG0318	PFAM AMP-dependent synthetase and ligase
C0V70_RS08415	COG0596	Alpha beta hydrolase
C0V70_RS08420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0V70_RS08425	COG1233	COG1233 Phytoene dehydrogenase and related
C0V70_RS08430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0V70_RS08435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0V70_RS08465	COG0708	Exodeoxyribonuclease III
C0V70_RS08500	COG0826	peptidase U32
C0V70_RS08535	COG5002	protein histidine kinase activity
C0V70_RS08535	COG3850	Histidine kinase
C0V70_RS08540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0V70_RS08540	COG0116	Belongs to the methyltransferase superfamily
C0V70_RS08545	COG0523	cobalamin synthesis protein
C0V70_RS08550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0V70_RS08580	COG1024	Enoyl-CoA hydratase
C0V70_RS08590	COG0492	ferredoxin-NADP+ reductase activity
C0V70_RS08620	COG0653	protein targeting
C0V70_RS08625	COG0739	heme binding
C0V70_RS08635	COG2766	serine protein kinase
C0V70_RS08640	COG2718	Belongs to the UPF0229 family
C0V70_RS08645	COG2719	SpoVR family
C0V70_RS08670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0V70_RS08675	COG1185	polyribonucleotide nucleotidyltransferase activity
C0V70_RS08680	COG0756	dUTP diphosphatase activity
C0V70_RS08695	COG2267	carboxylic ester hydrolase activity
C0V70_RS08720	COG4608	Belongs to the ABC transporter superfamily
C0V70_RS08725	COG0444	Belongs to the ABC transporter superfamily
C0V70_RS08730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0V70_RS08735	COG0601	transmembrane transport
C0V70_RS08740	COG0747	negative chemotaxis
C0V70_RS08745	COG4191	Histidine kinase
C0V70_RS08755	COG3639	organic phosphonate transmembrane transporter activity
C0V70_RS08760	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C0V70_RS08865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0V70_RS08875	COG0284	orotidine-5'-phosphate decarboxylase activity
C0V70_RS08880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0V70_RS08885	COG0540	Belongs to the ATCase OTCase family
C0V70_RS08895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0V70_RS08920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0V70_RS08930	COG1132	(ABC) transporter
C0V70_RS08935	COG1132	(ABC) transporter
C0V70_RS08940	COG3852	Histidine kinase
C0V70_RS08960	COG2234	aminopeptidase activity
C0V70_RS08965	COG0482	sulfurtransferase activity
C0V70_RS09000	COG0386	Belongs to the glutathione peroxidase family
C0V70_RS09005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS09005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS09040	COG0024	Methionine aminopeptidase
C0V70_RS09045	COG0745	RESPONSE REGULATOR receiver
C0V70_RS09055	COG0840	transmembrane signaling receptor activity
C0V70_RS09080	COG0697	spore germination
C0V70_RS09095	COG0367	asparagine synthase
C0V70_RS09100	COG0564	pseudouridine synthase activity
C0V70_RS09115	COG2166	iron-sulfur cluster assembly
C0V70_RS09120	COG0113	porphobilinogen synthase activity
C0V70_RS09125	COG3591	Belongs to the peptidase S1B family
C0V70_RS09145	COG1575	Belongs to the MenA family. Type 1 subfamily
C0V70_RS09150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0V70_RS09160	COG2226	methyltransferase
C0V70_RS09165	COG0142	geranyltranstransferase activity
C0V70_RS09230	COG3876	Protein conserved in bacteria
C0V70_RS09235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0V70_RS09240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0V70_RS09275	COG1704	LemA family
C0V70_RS09280	COG0826	peptidase U32
C0V70_RS09295	COG1187	pseudouridine synthase activity
C0V70_RS09315	COG0204	Acyl-transferase
C0V70_RS09330	COG0586	Pfam SNARE associated Golgi protein
C0V70_RS09345	COG0596	Alpha beta hydrolase
C0V70_RS09365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0V70_RS09385	COG2267	carboxylic ester hydrolase activity
C0V70_RS09410	COG4974	Belongs to the 'phage' integrase family
C0V70_RS09415	COG0745	RESPONSE REGULATOR receiver
C0V70_RS09450	COG0527	aspartate kinase activity
C0V70_RS09455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0V70_RS09460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0V70_RS09480	COG0531	amino acid
C0V70_RS09490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0V70_RS09490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0V70_RS09500	COG0778	Nitroreductase
C0V70_RS09510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0V70_RS09510	COG5322	oxidoreductase activity
C0V70_RS09515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0V70_RS09515	COG3320	Male sterility
C0V70_RS09520	COG1597	lipid kinase activity
C0V70_RS09525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0V70_RS09530	COG0318	PFAM AMP-dependent synthetase and ligase
C0V70_RS09540	COG3848	Pyruvate phosphate dikinase
C0V70_RS09540	COG0574	Belongs to the PEP-utilizing enzyme family
C0V70_RS09560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0V70_RS09570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0V70_RS09585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0V70_RS09590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0V70_RS09645	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0V70_RS09645	COG1024	Enoyl-CoA hydratase
C0V70_RS09685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0V70_RS09695	COG1774	PSP1 C-terminal conserved region
C0V70_RS09705	COG0017	Asparaginyl-tRNA synthetase
C0V70_RS09710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0V70_RS09720	COG0742	ribosomal rna small subunit methyltransferase
C0V70_RS09730	COG0737	Belongs to the 5'-nucleotidase family
C0V70_RS09735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0V70_RS09750	COG0513	Belongs to the DEAD box helicase family
C0V70_RS09805	COG0848	biopolymer transport protein
C0V70_RS09810	COG0811	peptide transport
C0V70_RS09835	COG0436	Aminotransferase
C0V70_RS09840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0V70_RS09845	COG4191	Histidine kinase
C0V70_RS09885	COG2205	protein histidine kinase activity
C0V70_RS09920	COG0745	RESPONSE REGULATOR receiver
C0V70_RS09980	COG2814	Major facilitator Superfamily
C0V70_RS09985	COG2204	response regulator
C0V70_RS09990	COG2814	Major facilitator Superfamily
C0V70_RS10000	COG4681	YaeQ
C0V70_RS10035	COG0776	regulation of translation
C0V70_RS10050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0V70_RS10055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0V70_RS10060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0V70_RS10070	COG0343	queuine tRNA-ribosyltransferase activity
C0V70_RS10075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0V70_RS10100	COG1192	Involved in chromosome partitioning
C0V70_RS10160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0V70_RS10175	COG1494	fructose-1,6-bisphosphatase
C0V70_RS10190	COG0560	Phosphoserine phosphatase
C0V70_RS10190	COG3830	Belongs to the UPF0237 family
C0V70_RS10230	COG0318	PFAM AMP-dependent synthetase and ligase
C0V70_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS10245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0V70_RS10290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0V70_RS10295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0V70_RS10335	COG0148	phosphopyruvate hydratase activity
C0V70_RS10340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0V70_RS10350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0V70_RS10410	COG0545	Peptidyl-prolyl cis-trans isomerase
C0V70_RS10415	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C0V70_RS10420	COG0328	RNA-DNA hybrid ribonuclease activity
C0V70_RS10450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0V70_RS10455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0V70_RS10460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0V70_RS10460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0V70_RS10465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0V70_RS10465	COG0195	Participates in both transcription termination and antitermination
C0V70_RS10470	COG0779	Required for maturation of 30S ribosomal subunits
C0V70_RS10485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0V70_RS10490	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0V70_RS10495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0V70_RS10505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0V70_RS10510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0V70_RS10545	COG0739	heme binding
C0V70_RS10550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C0V70_RS10560	COG0505	Belongs to the CarA family
C0V70_RS10565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C0V70_RS10570	COG0285	dihydrofolate synthase activity
C0V70_RS10580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0V70_RS10585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0V70_RS10605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0V70_RS10610	COG0335	large ribosomal subunit rRNA binding
C0V70_RS10615	COG4752	Belongs to the RNA methyltransferase TrmD family
C0V70_RS10625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0V70_RS10650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0V70_RS10650	COG0072	phenylalanine-tRNA ligase activity
C0V70_RS10660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C0V70_RS10660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0V70_RS10670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0V70_RS10680	COG1331	Highly conserved protein containing a thioredoxin domain
C0V70_RS10740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0V70_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS10795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0V70_RS10795	COG1333	cytochrome c biogenesis protein
C0V70_RS10805	COG0667	Aldo Keto reductase
C0V70_RS10810	COG3591	Belongs to the peptidase S1B family
C0V70_RS10855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0V70_RS10875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0V70_RS10895	COG0728	peptidoglycan biosynthetic process
C0V70_RS10900	COG2095	MarC family integral membrane protein
C0V70_RS10905	COG0670	Belongs to the BI1 family
C0V70_RS10910	COG1104	cysteine desulfurase activity
C0V70_RS10920	COG0802	atpase or kinase
C0V70_RS10925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0V70_RS10930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0V70_RS10940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C0V70_RS10945	COG3604	Transcriptional regulator
C0V70_RS10955	COG0189	ligase activity
C0V70_RS10975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0V70_RS10985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0V70_RS10990	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0V70_RS10995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0V70_RS11000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C0V70_RS11005	COG0745	RESPONSE REGULATOR receiver
C0V70_RS11010	COG1837	Belongs to the UPF0109 family
C0V70_RS11015	COG0228	four-way junction DNA binding
C0V70_RS11020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0V70_RS11050	COG1121	(ABC) transporter
C0V70_RS11055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0V70_RS11060	COG1607	acyl-coa hydrolase
C0V70_RS11065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0V70_RS11080	COG1166	arginine decarboxylase activity
C0V70_RS11120	COG1160	GTP binding
C0V70_RS11125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0V70_RS11130	COG0571	ribonuclease III activity
C0V70_RS11135	COG4974	Belongs to the 'phage' integrase family
C0V70_RS11145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0V70_RS11155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0V70_RS11160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0V70_RS11165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0V70_RS11175	COG2937	Belongs to the GPAT DAPAT family
C0V70_RS11180	COG0516	GMP reductase activity
C0V70_RS11180	COG0517	IMP dehydrogenase activity
C0V70_RS11190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0V70_RS11195	COG0181	hydroxymethylbilane synthase activity
C0V70_RS11200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0V70_RS11205	COG2205	protein histidine kinase activity
C0V70_RS11210	COG0745	RESPONSE REGULATOR receiver
C0V70_RS11215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0V70_RS11235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0V70_RS11240	COG0745	RESPONSE REGULATOR receiver
C0V70_RS11250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0V70_RS11295	COG0840	transmembrane signaling receptor activity
C0V70_RS11320	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0V70_RS11360	COG0811	peptide transport
C0V70_RS11415	COG1136	(ABC) transporter
C0V70_RS11430	COG2192	nodulation
C0V70_RS11440	COG1131	(ABC) transporter
C0V70_RS11445	COG0386	Belongs to the glutathione peroxidase family
C0V70_RS11455	COG1090	epimerase
C0V70_RS11460	COG0415	Belongs to the DNA photolyase family
C0V70_RS11475	COG1187	pseudouridine synthase activity
C0V70_RS11495	COG0427	acetyl-CoA hydrolase
C0V70_RS11500	COG0427	acetyl-CoA hydrolase
C0V70_RS11505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0V70_RS11530	COG2967	ApaG domain
C0V70_RS11540	COG1126	abc transporter atp-binding protein
C0V70_RS11565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0V70_RS11565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0V70_RS11580	COG3706	GGDEF domain
C0V70_RS11610	COG0612	Peptidase, M16
C0V70_RS11615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C0V70_RS11615	COG0321	lipoyl(octanoyl) transferase activity
C0V70_RS11640	COG0686	Belongs to the AlaDH PNT family
C0V70_RS11655	COG0346	lactoylglutathione lyase activity
C0V70_RS11715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0V70_RS11720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0V70_RS11730	COG0805	protein transport
C0V70_RS11745	COG0024	Methionine aminopeptidase
C0V70_RS11755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0V70_RS11760	COG0010	Belongs to the arginase family
C0V70_RS11765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0V70_RS11780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS11785	COG1034	ATP synthesis coupled electron transport
C0V70_RS11800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS11800	COG0649	NAD binding
C0V70_RS11805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0V70_RS11890	COG1741	Belongs to the pirin family
C0V70_RS11895	COG0583	DNA-binding transcription factor activity
C0V70_RS11950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0V70_RS11970	COG4221	oxidoreductase activity
C0V70_RS11975	COG0427	acetyl-CoA hydrolase
C0V70_RS12070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0V70_RS12075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0V70_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS12075	COG3321	synthase
C0V70_RS12075	COG0300	oxidoreductase activity
C0V70_RS12075	COG0318	PFAM AMP-dependent synthetase and ligase
C0V70_RS12095	COG0745	RESPONSE REGULATOR receiver
C0V70_RS12120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0V70_RS12125	COG2226	methyltransferase
C0V70_RS12130	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0V70_RS12140	COG3012	SEC-C Motif Domain Protein
C0V70_RS12160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0V70_RS12160	COG1199	ATP-dependent helicase activity
C0V70_RS12175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0V70_RS12180	COG2204	response regulator
C0V70_RS12195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0V70_RS12205	COG0596	Alpha beta hydrolase
C0V70_RS12205	COG2945	thiolester hydrolase activity
C0V70_RS12235	COG0586	Pfam SNARE associated Golgi protein
C0V70_RS12295	COG2066	Belongs to the glutaminase family
C0V70_RS12310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS12315	COG4628	conserved protein (DUF2132)
C0V70_RS12325	COG0183	Belongs to the thiolase family
C0V70_RS12370	COG0784	Response regulator, receiver
C0V70_RS12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0V70_RS12370	COG2198	Histidine kinase
C0V70_RS12370	COG2205	protein histidine kinase activity
C0V70_RS12375	COG2258	MOSC domain
C0V70_RS12380	COG0702	epimerase
C0V70_RS12390	COG1741	Belongs to the pirin family
C0V70_RS12395	COG0656	L-ascorbic acid biosynthetic process
C0V70_RS12400	COG0625	glutathione transferase activity
C0V70_RS12405	COG0386	Belongs to the glutathione peroxidase family
C0V70_RS12435	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS12450	COG2204	response regulator
C0V70_RS12485	COG4264	IucA IucC family
C0V70_RS12550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0V70_RS12560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0V70_RS12565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0V70_RS12565	COG0069	glutamate synthase activity
C0V70_RS12585	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS12590	COG0583	DNA-binding transcription factor activity
C0V70_RS12595	COG3118	belongs to the thioredoxin family
C0V70_RS12595	COG0492	ferredoxin-NADP+ reductase activity
C0V70_RS12605	COG2076	Multidrug Resistance protein
C0V70_RS12645	COG3437	response regulator, receiver
C0V70_RS12645	COG3850	Histidine kinase
C0V70_RS12645	COG4999	Histidine kinase
C0V70_RS12645	COG2205	protein histidine kinase activity
C0V70_RS12650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0V70_RS12670	COG0653	protein targeting
C0V70_RS12675	COG0653	protein targeting
C0V70_RS12700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0V70_RS12740	COG0745	RESPONSE REGULATOR receiver
C0V70_RS12745	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0V70_RS12755	COG0667	Aldo Keto reductase
C0V70_RS12770	COG1136	(ABC) transporter
C0V70_RS12775	COG0577	efflux transmembrane transporter activity
C0V70_RS12775	COG1136	(ABC) transporter
C0V70_RS12795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0V70_RS12805	COG5002	protein histidine kinase activity
C0V70_RS12825	COG2199	diguanylate cyclase activity
C0V70_RS12825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0V70_RS12830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0V70_RS12840	COG0254	rRNA binding
C0V70_RS12865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0V70_RS12905	COG0573	inorganic phosphate transmembrane transporter activity
C0V70_RS12910	COG0581	inorganic phosphate transmembrane transporter activity
C0V70_RS12915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0V70_RS12925	COG0745	RESPONSE REGULATOR receiver
C0V70_RS12930	COG5002	protein histidine kinase activity
C0V70_RS12940	COG0438	transferase activity, transferring glycosyl groups
C0V70_RS12960	COG0484	heat shock protein binding
C0V70_RS13000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0V70_RS13010	COG2832	Protein of unknown function (DUF454)
C0V70_RS13045	COG1404	Belongs to the peptidase S8 family
C0V70_RS13050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0V70_RS13110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0V70_RS13115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C0V70_RS13120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0V70_RS13135	COG0302	gtp cyclohydrolase
C0V70_RS13150	COG1047	Peptidyl-prolyl cis-trans
C0V70_RS13155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0V70_RS13165	COG0488	(ABC) transporter
C0V70_RS13175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0V70_RS13185	COG0488	(ABC) transporter
C0V70_RS13195	COG0217	transcriptional regulatory protein
C0V70_RS13215	COG0312	modulator of DNA gyrase
C0V70_RS13230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0V70_RS13235	COG0745	RESPONSE REGULATOR receiver
C0V70_RS13240	COG0671	phosphoesterase, PA-phosphatase related
C0V70_RS13245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0V70_RS13265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0V70_RS13285	COG5002	protein histidine kinase activity
C0V70_RS13290	COG0745	RESPONSE REGULATOR receiver
C0V70_RS13310	COG3186	Phenylalanine-4-hydroxylase
C0V70_RS13345	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0V70_RS13355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0V70_RS13385	COG1216	Glycosyl transferase, family 2
C0V70_RS13400	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0V70_RS13405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0V70_RS13410	COG2176	DNA-directed DNA polymerase activity
C0V70_RS13420	COG1509	lysine 2,3-aminomutase activity
C0V70_RS13510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C0V70_RS13525	COG2197	response regulator
C0V70_RS13530	COG2205	protein histidine kinase activity
C0V70_RS13555	COG4166	transmembrane transport
C0V70_RS13605	COG0281	malic enzyme
C0V70_RS13610	COG0443	Heat shock 70 kDa protein
C0V70_RS13620	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C0V70_RS13650	COG2072	flavoprotein involved in K transport
C0V70_RS13655	COG1408	metallophosphoesterase
C0V70_RS13670	COG2076	Multidrug Resistance protein
C0V70_RS13675	COG1230	cation diffusion facilitator family transporter
C0V70_RS13710	COG1132	(ABC) transporter
C0V70_RS13760	COG3237	CsbD-like
C0V70_RS13785	COG2205	protein histidine kinase activity
C0V70_RS13790	COG0784	Response regulator, receiver
C0V70_RS13795	COG4251	negative regulation of phosphorylation
C0V70_RS13815	COG3237	CsbD-like
C0V70_RS13870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0V70_RS13895	COG4221	oxidoreductase activity
C0V70_RS13895	COG3321	synthase
C0V70_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS13895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0V70_RS13920	COG0438	transferase activity, transferring glycosyl groups
C0V70_RS13930	COG1215	transferase activity, transferring glycosyl groups
C0V70_RS13995	COG1755	Isoprenylcysteine carboxyl methyltransferase
C0V70_RS14035	COG1858	cytochrome C peroxidase
C0V70_RS14045	COG0010	Belongs to the arginase family
C0V70_RS14065	COG0668	transmembrane transport
C0V70_RS14095	COG3845	ABC transporter
C0V70_RS14100	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0V70_RS14105	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0V70_RS14110	COG0784	Response regulator, receiver
C0V70_RS14110	COG2198	Histidine kinase
C0V70_RS14110	COG2205	protein histidine kinase activity
C0V70_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS14135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C0V70_RS14155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0V70_RS14170	COG2267	carboxylic ester hydrolase activity
C0V70_RS14175	COG4589	Belongs to the CDS family
C0V70_RS14185	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C0V70_RS14200	COG0840	transmembrane signaling receptor activity
C0V70_RS14215	COG1803	Methylglyoxal synthase
C0V70_RS14220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0V70_RS14225	COG2011	ABC-type metal ion transport system permease component
C0V70_RS14240	COG0702	epimerase
C0V70_RS14270	COG0583	DNA-binding transcription factor activity
C0V70_RS14275	COG2353	YceI-like domain
C0V70_RS14290	COG1408	metallophosphoesterase
C0V70_RS14300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0V70_RS14315	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C0V70_RS14340	COG0519	Catalyzes the synthesis of GMP from XMP
C0V70_RS14370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0V70_RS14400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0V70_RS14410	COG0501	Belongs to the peptidase M48B family
C0V70_RS14420	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C0V70_RS14425	COG0726	polysaccharide deacetylase
C0V70_RS14455	COG1570	exodeoxyribonuclease VII activity
C0V70_RS14460	COG0793	Belongs to the peptidase S41A family
C0V70_RS14480	COG1078	dGTPase activity
C0V70_RS14490	COG2204	response regulator
C0V70_RS14495	COG0823	Involved in the tonB-independent uptake of proteins
C0V70_RS14510	COG0811	peptide transport
C0V70_RS14530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C0V70_RS14535	COG0616	signal peptide processing
C0V70_RS14555	COG1652	LysM domain
C0V70_RS14570	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS14575	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS14580	COG0166	Belongs to the GPI family
C0V70_RS14590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0V70_RS14595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0V70_RS14600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0V70_RS14605	COG0515	serine threonine protein kinase
C0V70_RS14635	COG0183	Belongs to the thiolase family
C0V70_RS14665	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS14670	COG1024	Enoyl-CoA hydratase
C0V70_RS14675	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0V70_RS14680	COG0268	Binds directly to 16S ribosomal RNA
C0V70_RS14715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0V70_RS14725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0V70_RS14730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0V70_RS14750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0V70_RS14755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0V70_RS14760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0V70_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
C0V70_RS14770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0V70_RS14780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0V70_RS14785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0V70_RS14815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0V70_RS14825	COG1720	tRNA m6t6A37 methyltransferase activity
C0V70_RS14835	COG0300	oxidoreductase activity
C0V70_RS14885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0V70_RS14900	COG2207	Transcriptional regulator
C0V70_RS14915	COG1253	flavin adenine dinucleotide binding
C0V70_RS14930	COG2885	chlorophyll binding
C0V70_RS14935	COG2119	membrane
C0V70_RS14940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0V70_RS14945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0V70_RS14950	COG0586	Pfam SNARE associated Golgi protein
C0V70_RS14955	COG0386	Belongs to the glutathione peroxidase family
C0V70_RS14960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C0V70_RS14975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0V70_RS14980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0V70_RS14985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0V70_RS15090	COG0840	transmembrane signaling receptor activity
C0V70_RS15120	COG1663	tetraacyldisaccharide 4'-kinase activity
C0V70_RS15125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0V70_RS15135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0V70_RS15145	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0V70_RS15160	COG1136	(ABC) transporter
C0V70_RS15180	COG3956	TIGRFAM MazG family protein
C0V70_RS15185	COG0237	dephospho-CoA kinase activity
C0V70_RS15285	COG1191	sigma factor activity
C0V70_RS15290	COG2894	cell division
C0V70_RS15300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0V70_RS15305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0V70_RS15310	COG1684	flagellar biosynthetic protein fliR
C0V70_RS15315	COG1987	bacterial-type flagellum assembly
C0V70_RS15320	COG1338	Plays a role in the flagellum-specific transport system
C0V70_RS15355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0V70_RS15355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0V70_RS15370	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0V70_RS15375	COG2385	sporulation resulting in formation of a cellular spore
C0V70_RS15395	COG0583	DNA-binding transcription factor activity
C0V70_RS15400	COG0322	excinuclease ABC activity
C0V70_RS15445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0V70_RS15480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0V70_RS15480	COG3608	succinylglutamate desuccinylase aspartoacylase
C0V70_RS15485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C0V70_RS15505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0V70_RS15575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0V70_RS15590	COG0018	arginyl-trna synthetase
C0V70_RS15605	COG0583	DNA-binding transcription factor activity
C0V70_RS15615	COG4172	Belongs to the ABC transporter superfamily
C0V70_RS15620	COG4721	ABC-type cobalt transport system, permease component
C0V70_RS15625	COG0281	malic enzyme
C0V70_RS15625	COG0280	phosphate acetyltransferase
C0V70_RS15630	COG0251	oxidation-reduction process
C0V70_RS15645	COG0194	GDP metabolic process
C0V70_RS15650	COG1561	YicC-like family, N-terminal region
C0V70_RS15665	COG2204	response regulator
C0V70_RS15670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0V70_RS15735	COG0101	tRNA pseudouridine synthase activity
C0V70_RS15745	COG0583	DNA-binding transcription factor activity
C0V70_RS15755	COG0778	Nitroreductase
C0V70_RS15765	COG0583	DNA-binding transcription factor activity
C0V70_RS15775	COG2205	protein histidine kinase activity
C0V70_RS15795	COG0583	DNA-binding transcription factor activity
C0V70_RS15800	COG1643	Atp-dependent helicase
C0V70_RS15815	COG1335	isochorismatase
C0V70_RS15820	COG0730	response to heat
C0V70_RS15835	COG5002	protein histidine kinase activity
C0V70_RS15835	COG5002	protein histidine kinase activity
C0V70_RS15840	COG5002	protein histidine kinase activity
C0V70_RS15850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0V70_RS15910	COG1981	membrane
C0V70_RS15915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0V70_RS15920	COG1309	transcriptional regulator
C0V70_RS15945	COG0436	Aminotransferase
C0V70_RS15950	COG0235	Class ii aldolase
C0V70_RS15955	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C0V70_RS15960	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C0V70_RS15995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0V70_RS16000	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C0V70_RS16005	COG4191	Histidine kinase
C0V70_RS16035	COG0028	Belongs to the TPP enzyme family
C0V70_RS16035	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C0V70_RS16055	COG1213	nucleotidyl transferase
C0V70_RS16065	COG0488	(ABC) transporter
C0V70_RS16070	COG1217	gtp-binding protein TYPA
C0V70_RS16080	COG0745	RESPONSE REGULATOR receiver
C0V70_RS16085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0V70_RS16140	COG1846	Transcriptional regulator
C0V70_RS16145	COG0598	Magnesium transport protein CorA
C0V70_RS16150	COG1970	mechanosensitive ion channel activity
C0V70_RS16185	COG0444	Belongs to the ABC transporter superfamily
C0V70_RS16190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0V70_RS16200	COG0747	negative chemotaxis
C0V70_RS16215	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C0V70_RS16230	COG0003	Pfam Anion-transporting ATPase
C0V70_RS16245	COG0626	cystathionine gamma-synthase activity
C0V70_RS16255	COG2199	diguanylate cyclase activity
C0V70_RS16255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0V70_RS16270	COG5002	protein histidine kinase activity
C0V70_RS16295	COG2070	2-Nitropropane dioxygenase
C0V70_RS16310	COG0339	signal peptide processing
C0V70_RS16330	COG0463	Glycosyl transferase, family 2
C0V70_RS16340	COG0698	ribose 5-phosphate isomerase
C0V70_RS16345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0V70_RS16355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0V70_RS16355	COG0116	Belongs to the methyltransferase superfamily
C0V70_RS16370	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS16395	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C0V70_RS16400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0V70_RS16405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0V70_RS16410	COG0205	6-phosphofructokinase activity
C0V70_RS16425	COG1027	Aspartate ammonia-lyase
C0V70_RS16445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0V70_RS16465	COG1475	DNA binding
C0V70_RS16470	COG1192	Involved in chromosome partitioning
C0V70_RS16480	COG1970	mechanosensitive ion channel activity
C0V70_RS16490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0V70_RS16495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0V70_RS16530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0V70_RS16540	COG0798	PFAM Bile acid sodium symporter
C0V70_RS16550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0V70_RS16555	COG0346	lactoylglutathione lyase activity
C0V70_RS16595	COG0305	Participates in initiation and elongation during chromosome replication
C0V70_RS16605	COG5002	protein histidine kinase activity
C0V70_RS16620	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C0V70_RS16625	COG2197	response regulator
C0V70_RS16660	COG2205	protein histidine kinase activity
C0V70_RS16665	COG2814	Major facilitator Superfamily
C0V70_RS16670	COG1950	PFAM Membrane protein of
C0V70_RS16675	COG2226	methyltransferase
C0V70_RS16710	COG0500	methyltransferase
C0V70_RS16730	COG4807	Protein conserved in bacteria
C0V70_RS16745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0V70_RS16765	COG4181	ATPase activity
C0V70_RS16775	COG0572	uridine kinase
C0V70_RS16780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0V70_RS16795	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS16850	COG2267	carboxylic ester hydrolase activity
C0V70_RS16855	COG2124	cytochrome p450
C0V70_RS16870	COG2801	Transposase and inactivated derivatives
C0V70_RS16900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C0V70_RS16915	COG1078	dGTPase activity
C0V70_RS16925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0V70_RS16935	COG5002	protein histidine kinase activity
C0V70_RS16985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0V70_RS17010	COG2197	response regulator
C0V70_RS17015	COG2202	Pas domain
C0V70_RS17015	COG2205	protein histidine kinase activity
C0V70_RS17050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0V70_RS17055	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0V70_RS17060	COG0840	transmembrane signaling receptor activity
C0V70_RS17065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C0V70_RS17085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0V70_RS17100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0V70_RS17105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0V70_RS17150	COG0157	Belongs to the NadC ModD family
C0V70_RS17180	COG0022	dehydrogenase e1 component
C0V70_RS17215	COG0492	ferredoxin-NADP+ reductase activity
C0V70_RS17220	COG1253	flavin adenine dinucleotide binding
C0V70_RS17235	COG0494	nUDIX hydrolase
C0V70_RS17250	COG0300	oxidoreductase activity
C0V70_RS17290	COG2204	response regulator
C0V70_RS17300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0V70_RS17305	COG0741	lytic transglycosylase activity
C0V70_RS17320	COG2971	BadF BadG BcrA BcrD
C0V70_RS17325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0V70_RS17330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0V70_RS17355	COG1196	nuclear chromosome segregation
C0V70_RS17360	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0V70_RS17365	COG3118	belongs to the thioredoxin family
C0V70_RS17430	COG1472	Belongs to the glycosyl hydrolase 3 family
C0V70_RS17435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0V70_RS17440	COG0601	transmembrane transport
C0V70_RS17455	COG1077	Cell shape determining protein MreB Mrl
C0V70_RS17460	COG0813	purine-nucleoside phosphorylase activity
C0V70_RS17470	COG0484	heat shock protein binding
C0V70_RS17475	COG0443	Heat shock 70 kDa protein
C0V70_RS17535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0V70_RS17610	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0V70_RS17710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0V70_RS17715	COG0612	Peptidase, M16
C0V70_RS17755	COG0859	PFAM glycosyl transferase family 9
C0V70_RS17780	COG3959	Transketolase, thiamine diphosphate binding domain
C0V70_RS17785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0V70_RS17795	COG1215	transferase activity, transferring glycosyl groups
C0V70_RS17810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0V70_RS17825	COG0463	Glycosyl transferase, family 2
C0V70_RS17850	COG2192	nodulation
C0V70_RS17860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0V70_RS17880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0V70_RS17890	COG2192	nodulation
C0V70_RS17905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0V70_RS17905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0V70_RS17920	COG0511	ligase activity, forming carbon-carbon bonds
C0V70_RS17925	COG0439	Biotin carboxylase
C0V70_RS17930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0V70_RS17940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0V70_RS17940	COG1116	anion transmembrane transporter activity
C0V70_RS17945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0V70_RS17990	COG0203	ribosomal protein L17
C0V70_RS18005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0V70_RS18010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0V70_RS18015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0V70_RS18025	COG0201	protein transport
C0V70_RS18030	COG0200	Binds to the 23S rRNA
C0V70_RS18035	COG1841	ribosomal large subunit assembly
C0V70_RS18040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0V70_RS18045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0V70_RS18050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0V70_RS18055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0V70_RS18060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0V70_RS18065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0V70_RS18070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0V70_RS18075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0V70_RS18080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0V70_RS18085	COG0255	Belongs to the universal ribosomal protein uL29 family
C0V70_RS18090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0V70_RS18095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0V70_RS18100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0V70_RS18105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0V70_RS18110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0V70_RS18120	COG0088	Forms part of the polypeptide exit tunnel
C0V70_RS18125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0V70_RS18130	COG0051	transcription antitermination factor activity, RNA binding
C0V70_RS18135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0V70_RS18140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0V70_RS18145	COG0049	tRNA binding
C0V70_RS18150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0V70_RS18155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0V70_RS18160	COG0085	RNA polymerase activity
C0V70_RS18165	COG0222	ribosome binding
C0V70_RS18175	COG0081	regulation of translation
C0V70_RS18180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0V70_RS18200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0V70_RS18225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0V70_RS18235	COG0442	prolyl-tRNA aminoacylation
C0V70_RS18240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C0V70_RS18245	COG0740	serine-type endopeptidase activity
C0V70_RS18255	COG2050	protein possibly involved in aromatic compounds catabolism
C0V70_RS18260	COG2255	four-way junction helicase activity
C0V70_RS18265	COG0632	four-way junction helicase activity
C0V70_RS18270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0V70_RS18275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0V70_RS18280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0V70_RS18285	COG0509	glycine decarboxylation via glycine cleavage system
C0V70_RS18310	COG1722	exodeoxyribonuclease VII activity
C0V70_RS18335	COG1706	bacterial-type flagellum-dependent cell motility
C0V70_RS18355	COG4786	Flagellar basal body rod
C0V70_RS18355	COG1256	bacterial-type flagellum assembly
C0V70_RS18370	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C0V70_RS18400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0V70_RS18410	COG1012	belongs to the aldehyde dehydrogenase family
C0V70_RS18435	COG4191	Histidine kinase
C0V70_RS18440	COG2201	protein-glutamate methylesterase activity
C0V70_RS18455	COG0354	folic acid binding
C0V70_RS18460	COG0316	Belongs to the HesB IscA family
C0V70_RS18470	COG2096	Adenosyltransferase
C0V70_RS18475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0V70_RS18475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0V70_RS18475	COG1703	isobutyryl-CoA mutase activity
C0V70_RS18490	COG0840	transmembrane signaling receptor activity
C0V70_RS18500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0V70_RS18540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0V70_RS18545	COG3178	'Phosphotransferase
C0V70_RS18570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0V70_RS18575	COG1960	acyl-CoA dehydrogenase activity
C0V70_RS18580	COG2086	electron transfer activity
C0V70_RS18585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C0V70_RS18600	COG1696	Membrane protein involved in D-alanine export
C0V70_RS18610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0V70_RS18620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0V70_RS18630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0V70_RS18650	COG0489	protein tyrosine kinase activity
C0V70_RS18660	COG0741	lytic transglycosylase activity
C0V70_RS18670	COG0012	GTP binding
C0V70_RS18675	COG0193	aminoacyl-tRNA hydrolase activity
C0V70_RS18680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0V70_RS18690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0V70_RS18705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0V70_RS18735	COG0242	peptide deformylase activity
C0V70_RS18740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0V70_RS18760	COG2986	histidine ammonia-lyase
C0V70_RS18765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0V70_RS18790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0V70_RS18800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0V70_RS18810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0V70_RS18815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0V70_RS18840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0V70_RS18845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0V70_RS18850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0V70_RS18855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0V70_RS18860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0V70_RS18880	COG1475	DNA binding
C0V70_RS18885	COG1192	Involved in chromosome partitioning
C0V70_RS18890	COG0357	Ribosomal RNA small subunit methyltransferase G
C0V70_RS18895	COG0445	tRNA wobble uridine modification
C0V70_RS18900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0V70_RS18905	COG0706	membrane insertase activity
C0V70_RS18915	COG0594	ribonuclease P activity