locus-tag	class	description
BRDCF_RS00005	COG0445	tRNA wobble uridine modification
BRDCF_RS00010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BRDCF_RS00020	COG0039	L-malate dehydrogenase activity
BRDCF_RS00035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRDCF_RS00060	COG1053	succinate dehydrogenase
BRDCF_RS00065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BRDCF_RS00075	COG2255	four-way junction helicase activity
BRDCF_RS00080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRDCF_RS00085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRDCF_RS00105	COG1253	flavin adenine dinucleotide binding
BRDCF_RS00125	COG0012	GTP binding
BRDCF_RS00135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRDCF_RS00140	COG1136	(ABC) transporter
BRDCF_RS00140	COG0577	efflux transmembrane transporter activity
BRDCF_RS00145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BRDCF_RS00150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BRDCF_RS00210	COG0733	neurotransmitter:sodium symporter activity
BRDCF_RS00220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRDCF_RS00225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BRDCF_RS00260	COG4771	TonB-dependent receptor
BRDCF_RS00305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BRDCF_RS00310	COG1253	flavin adenine dinucleotide binding
BRDCF_RS00315	COG0489	protein tyrosine kinase activity
BRDCF_RS00320	COG3591	Belongs to the peptidase S1B family
BRDCF_RS00325	COG1929	Belongs to the glycerate kinase type-1 family
BRDCF_RS00330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BRDCF_RS00350	COG1136	(ABC) transporter
BRDCF_RS00355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BRDCF_RS00375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRDCF_RS00380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRDCF_RS00385	COG0481	GTPase activity
BRDCF_RS00395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BRDCF_RS00415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRDCF_RS00425	COG1695	Transcriptional regulator
BRDCF_RS00435	COG0156	8-amino-7-oxononanoate synthase activity
BRDCF_RS00440	COG3385	transposase activity
BRDCF_RS00445	COG1309	transcriptional regulator
BRDCF_RS00455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS00470	COG3118	belongs to the thioredoxin family
BRDCF_RS00485	COG0142	geranyltranstransferase activity
BRDCF_RS00495	COG0612	Peptidase, M16
BRDCF_RS00505	COG0826	peptidase U32
BRDCF_RS00510	COG0470	DNA polymerase III
BRDCF_RS00515	COG1774	PSP1 C-terminal conserved region
BRDCF_RS00525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BRDCF_RS00540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRDCF_RS00550	COG0528	UMP kinase activity
BRDCF_RS00555	COG0233	cytoplasmic translational termination
BRDCF_RS00565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRDCF_RS00575	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRDCF_RS00580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRDCF_RS00640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BRDCF_RS00670	COG3385	transposase activity
BRDCF_RS00685	COG4771	TonB-dependent receptor
BRDCF_RS00705	COG0126	phosphoglycerate kinase activity
BRDCF_RS00710	COG0116	Belongs to the methyltransferase superfamily
BRDCF_RS00710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRDCF_RS00715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRDCF_RS00720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRDCF_RS00725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRDCF_RS00730	COG1966	Carbon starvation protein
BRDCF_RS00750	COG0668	transmembrane transport
BRDCF_RS00770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BRDCF_RS00770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BRDCF_RS00775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRDCF_RS00785	COG0772	Belongs to the SEDS family
BRDCF_RS00790	COG0768	penicillin binding
BRDCF_RS00810	COG0138	bifunctional purine biosynthesis protein purh
BRDCF_RS00820	COG1522	sequence-specific DNA binding
BRDCF_RS00840	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRDCF_RS00850	COG2890	protein-(glutamine-N5) methyltransferase activity
BRDCF_RS00865	COG3279	Response regulator of the LytR AlgR family
BRDCF_RS00870	COG2972	Histidine kinase
BRDCF_RS00875	COG1136	(ABC) transporter
BRDCF_RS00875	COG0577	efflux transmembrane transporter activity
BRDCF_RS00880	COG1136	(ABC) transporter
BRDCF_RS00885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS00900	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BRDCF_RS00910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BRDCF_RS00930	COG1506	peptidase
BRDCF_RS00945	COG1045	serine acetyltransferase
BRDCF_RS00950	COG1854	S-ribosylhomocysteine lyase activity
BRDCF_RS00965	COG5002	protein histidine kinase activity
BRDCF_RS00965	COG0784	Response regulator, receiver
BRDCF_RS00965	COG2205	protein histidine kinase activity
BRDCF_RS00975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BRDCF_RS00980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BRDCF_RS00985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRDCF_RS00995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRDCF_RS01010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRDCF_RS01015	COG0572	uridine kinase
BRDCF_RS01045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRDCF_RS01050	COG0756	dUTP diphosphatase activity
BRDCF_RS01070	COG1127	ABC transporter
BRDCF_RS01075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRDCF_RS01080	COG1519	Transferase
BRDCF_RS01100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRDCF_RS01105	COG0052	Belongs to the universal ribosomal protein uS2 family
BRDCF_RS01110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRDCF_RS01120	COG0205	6-phosphofructokinase activity
BRDCF_RS01125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BRDCF_RS01130	COG1663	tetraacyldisaccharide 4'-kinase activity
BRDCF_RS01135	COG4206	TonB-dependent receptor
BRDCF_RS01135	COG1629	transport
BRDCF_RS01145	COG0006	proline dipeptidase activity
BRDCF_RS01150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BRDCF_RS01180	COG1629	transport
BRDCF_RS01180	COG4206	TonB-dependent receptor
BRDCF_RS01200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BRDCF_RS01205	COG1278	Cold shock
BRDCF_RS01225	COG2502	aspartate--ammonia ligase
BRDCF_RS01230	COG0546	phosphoglycolate phosphatase activity
BRDCF_RS01255	COG2770	Histidine kinase
BRDCF_RS01255	COG2208	phosphoserine phosphatase activity
BRDCF_RS01280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BRDCF_RS01280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRDCF_RS01295	COG1773	rubredoxin
BRDCF_RS01295	COG1592	Rubrerythrin
BRDCF_RS01310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BRDCF_RS01360	COG0612	Peptidase, M16
BRDCF_RS01380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRDCF_RS01405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BRDCF_RS01410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BRDCF_RS01415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BRDCF_RS01420	COG2003	Belongs to the UPF0758 family
BRDCF_RS01425	COG0268	Binds directly to 16S ribosomal RNA
BRDCF_RS01440	COG0750	zinc metalloprotease
BRDCF_RS01445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BRDCF_RS01460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRDCF_RS01465	COG0242	peptide deformylase activity
BRDCF_RS01510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRDCF_RS01515	COG0228	four-way junction DNA binding
BRDCF_RS01530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BRDCF_RS01545	COG3104	oligopeptide transport
BRDCF_RS01560	COG2195	Cleaves the N-terminal amino acid of tripeptides
BRDCF_RS01565	COG0360	Binds together with S18 to 16S ribosomal RNA
BRDCF_RS01570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BRDCF_RS01575	COG0359	binds to the 23S rRNA
BRDCF_RS01605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRDCF_RS01615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRDCF_RS01630	COG1242	4 iron, 4 sulfur cluster binding
BRDCF_RS01635	COG2731	YhcH YjgK YiaL family protein
BRDCF_RS01640	COG0791	NLP P60 protein
BRDCF_RS01645	COG4948	Mandelate Racemase Muconate Lactonizing
BRDCF_RS01660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRDCF_RS01665	COG1185	polyribonucleotide nucleotidyltransferase activity
BRDCF_RS01670	COG4771	TonB-dependent receptor
BRDCF_RS01680	COG2986	histidine ammonia-lyase
BRDCF_RS01685	COG1228	amidohydrolase
BRDCF_RS01690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BRDCF_RS01705	COG0626	cystathionine gamma-synthase activity
BRDCF_RS01710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRDCF_RS01710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BRDCF_RS01710	COG1013	pyruvate-flavodoxin oxidoreductase activity
BRDCF_RS01710	COG0674	pyruvate-flavodoxin oxidoreductase activity
BRDCF_RS01720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BRDCF_RS01785	COG2855	membrane
BRDCF_RS01790	COG0583	DNA-binding transcription factor activity
BRDCF_RS01800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BRDCF_RS01810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BRDCF_RS01815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BRDCF_RS01815	COG1215	transferase activity, transferring glycosyl groups
BRDCF_RS01835	COG3876	Protein conserved in bacteria
BRDCF_RS01840	COG1940	carbohydrate kinase activity
BRDCF_RS01855	COG1629	transport
BRDCF_RS01890	COG0445	tRNA wobble uridine modification
BRDCF_RS01895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BRDCF_RS01895	COG2755	lipolytic protein G-D-S-L family
BRDCF_RS01905	COG3385	transposase activity
BRDCF_RS01915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BRDCF_RS01940	COG1431	PFAM Stem cell self-renewal protein Piwi
BRDCF_RS01945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRDCF_RS01965	COG3645	SOS response
BRDCF_RS01990	COG0488	(ABC) transporter
BRDCF_RS02015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRDCF_RS02040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRDCF_RS02045	COG0083	homoserine kinase activity
BRDCF_RS02055	COG0527	aspartate kinase activity
BRDCF_RS02055	COG0460	homoserine dehydrogenase
BRDCF_RS02075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BRDCF_RS02080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRDCF_RS02095	COG4771	TonB-dependent receptor
BRDCF_RS02100	COG4124	Belongs to the glycosyl hydrolase 26 family
BRDCF_RS02110	COG2207	Transcriptional regulator
BRDCF_RS02110	COG4753	response regulator
BRDCF_RS02115	COG0393	Putative heavy-metal-binding
BRDCF_RS02120	COG2195	Cleaves the N-terminal amino acid of tripeptides
BRDCF_RS02125	COG0428	transporter
BRDCF_RS02140	COG0137	argininosuccinate synthase activity
BRDCF_RS02145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BRDCF_RS02160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRDCF_RS02170	COG0165	Argininosuccinate lyase
BRDCF_RS02175	COG2855	membrane
BRDCF_RS02215	COG1960	acyl-CoA dehydrogenase activity
BRDCF_RS02220	COG2086	electron transfer activity
BRDCF_RS02225	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BRDCF_RS02245	COG4717	serine-type aminopeptidase activity
BRDCF_RS02265	COG1629	transport
BRDCF_RS02265	COG4771	TonB-dependent receptor
BRDCF_RS02290	COG0724	RNA recognition motif
BRDCF_RS02305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRDCF_RS02310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BRDCF_RS02315	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BRDCF_RS02320	COG0540	Belongs to the ATCase OTCase family
BRDCF_RS02350	COG0545	Peptidyl-prolyl cis-trans isomerase
BRDCF_RS02355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BRDCF_RS02360	COG0010	Belongs to the arginase family
BRDCF_RS02365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BRDCF_RS02365	COG0517	IMP dehydrogenase activity
BRDCF_RS02370	COG0514	ATP-dependent DNA helicase (RecQ)
BRDCF_RS02375	COG0174	glutamine synthetase
BRDCF_RS02390	COG1132	(ABC) transporter
BRDCF_RS02395	COG0318	PFAM AMP-dependent synthetase and ligase
BRDCF_RS02405	COG0793	Belongs to the peptidase S41A family
BRDCF_RS02405	COG3409	Peptidoglycan-binding domain 1 protein
BRDCF_RS02420	COG0017	Asparaginyl-tRNA synthetase
BRDCF_RS02425	COG1649	PFAM Uncharacterised BCR, COG1649
BRDCF_RS02430	COG1785	Belongs to the alkaline phosphatase family
BRDCF_RS02450	COG0811	peptide transport
BRDCF_RS02455	COG0252	asparaginase activity
BRDCF_RS02460	COG0084	hydrolase, TatD family'
BRDCF_RS02465	COG0758	DNA mediated transformation
BRDCF_RS02470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BRDCF_RS02475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BRDCF_RS02480	COG0698	ribose 5-phosphate isomerase
BRDCF_RS02490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BRDCF_RS02510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRDCF_RS02515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BRDCF_RS02520	COG0772	Belongs to the SEDS family
BRDCF_RS02525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BRDCF_RS02530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRDCF_RS02535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BRDCF_RS02540	COG0768	penicillin binding
BRDCF_RS02550	COG0275	rRNA processing
BRDCF_RS02555	COG2001	Belongs to the MraZ family
BRDCF_RS02560	COG0739	heme binding
BRDCF_RS02565	COG0488	(ABC) transporter
BRDCF_RS02570	COG0488	(ABC) transporter
BRDCF_RS02575	COG0569	domain protein
BRDCF_RS02590	COG0577	efflux transmembrane transporter activity
BRDCF_RS02590	COG1136	(ABC) transporter
BRDCF_RS02595	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BRDCF_RS02605	COG0302	gtp cyclohydrolase
BRDCF_RS02610	COG5002	protein histidine kinase activity
BRDCF_RS02615	COG0745	RESPONSE REGULATOR receiver
BRDCF_RS02635	COG0517	IMP dehydrogenase activity
BRDCF_RS02635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BRDCF_RS02635	COG0617	tRNA 3'-terminal CCA addition
BRDCF_RS02650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BRDCF_RS02660	COG1435	thymidine kinase activity
BRDCF_RS02670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BRDCF_RS02680	COG4152	abc transporter atp-binding protein
BRDCF_RS02695	COG0737	Belongs to the 5'-nucleotidase family
BRDCF_RS02700	COG1022	Amp-dependent synthetase and ligase
BRDCF_RS02715	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRDCF_RS02730	COG3385	transposase activity
BRDCF_RS02750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BRDCF_RS02755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRDCF_RS02760	COG4974	Belongs to the 'phage' integrase family
BRDCF_RS02765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BRDCF_RS02770	COG0095	Lipoate-protein ligase
BRDCF_RS02775	COG0671	phosphoesterase, PA-phosphatase related
BRDCF_RS02780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRDCF_RS02785	COG0563	adenylate kinase activity
BRDCF_RS02795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BRDCF_RS02805	COG0741	lytic transglycosylase activity
BRDCF_RS02805	COG1388	LysM domain
BRDCF_RS02815	COG1475	DNA binding
BRDCF_RS02820	COG1192	Involved in chromosome partitioning
BRDCF_RS02830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRDCF_RS02840	COG2204	response regulator
BRDCF_RS02850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRDCF_RS02855	COG5000	phosphorelay sensor kinase activity
BRDCF_RS02860	COG1160	GTP binding
BRDCF_RS02870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRDCF_RS02870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRDCF_RS02875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRDCF_RS02880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRDCF_RS02885	COG1570	exodeoxyribonuclease VII activity
BRDCF_RS02895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BRDCF_RS02905	COG0297	glycogen (starch) synthase activity
BRDCF_RS02915	COG0058	SHG alpha-glucan phosphorylase activity
BRDCF_RS02920	COG0196	riboflavin kinase activity
BRDCF_RS02930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRDCF_RS02935	COG0537	adenosine 5'-monophosphoramidase activity
BRDCF_RS02945	COG1214	PFAM Peptidase M22, glycoprotease
BRDCF_RS02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BRDCF_RS02985	COG0590	tRNA wobble adenosine to inosine editing
BRDCF_RS02995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRDCF_RS03000	COG1595	DNA-templated transcription, initiation
BRDCF_RS03050	COG2818	Glycosylase
BRDCF_RS03070	COG2217	Heavy metal translocating P-type atpase
BRDCF_RS03110	COG1528	Iron-storage protein
BRDCF_RS03120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BRDCF_RS03125	COG3537	Alpha-1,2-mannosidase
BRDCF_RS03145	COG0463	Glycosyl transferase, family 2
BRDCF_RS03175	COG1993	acr, cog1993
BRDCF_RS03180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BRDCF_RS03185	COG0531	amino acid
BRDCF_RS03190	COG1342	Belongs to the UPF0251 family
BRDCF_RS03205	COG0028	Belongs to the TPP enzyme family
BRDCF_RS03215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRDCF_RS03220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRDCF_RS03225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BRDCF_RS03230	COG0710	3-dehydroquinate dehydratase activity
BRDCF_RS03235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BRDCF_RS03240	COG0287	Prephenate dehydrogenase
BRDCF_RS03245	COG0436	Aminotransferase
BRDCF_RS03250	COG1605	Chorismate mutase
BRDCF_RS03250	COG0077	Prephenate dehydratase
BRDCF_RS03270	COG2076	Multidrug Resistance protein
BRDCF_RS03280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRDCF_RS03295	COG1629	transport
BRDCF_RS03310	COG0596	Alpha beta hydrolase
BRDCF_RS03320	COG1794	racemase activity, acting on amino acids and derivatives
BRDCF_RS03330	COG0071	Belongs to the small heat shock protein (HSP20) family
BRDCF_RS03335	COG0517	IMP dehydrogenase activity
BRDCF_RS03335	COG0516	GMP reductase activity
BRDCF_RS03340	COG0534	Mate efflux family protein
BRDCF_RS03360	COG4771	TonB-dependent receptor
BRDCF_RS03375	COG0784	Response regulator, receiver
BRDCF_RS03380	COG2205	protein histidine kinase activity
BRDCF_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BRDCF_RS03395	COG0371	Dehydrogenase
BRDCF_RS03405	COG1355	regulation of microtubule-based process
BRDCF_RS03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRDCF_RS03440	COG0656	L-ascorbic acid biosynthetic process
BRDCF_RS03450	COG0101	tRNA pseudouridine synthase activity
BRDCF_RS03455	COG0714	Associated with various cellular activities
BRDCF_RS03510	COG2832	Protein of unknown function (DUF454)
BRDCF_RS03515	COG1115	amino acid carrier protein
BRDCF_RS03530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BRDCF_RS03535	COG0193	aminoacyl-tRNA hydrolase activity
BRDCF_RS03540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BRDCF_RS03545	COG1482	cell wall glycoprotein biosynthetic process
BRDCF_RS03580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRDCF_RS03585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRDCF_RS03595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BRDCF_RS03600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BRDCF_RS03605	COG0195	Participates in both transcription termination and antitermination
BRDCF_RS03610	COG0779	Required for maturation of 30S ribosomal subunits
BRDCF_RS03615	COG1078	dGTPase activity
BRDCF_RS03620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRDCF_RS03625	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRDCF_RS03625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRDCF_RS03630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRDCF_RS03650	COG0442	prolyl-tRNA aminoacylation
BRDCF_RS03665	COG0037	tRNA processing
BRDCF_RS03670	COG0616	signal peptide processing
BRDCF_RS03675	COG0745	RESPONSE REGULATOR receiver
BRDCF_RS03735	COG0493	'glutamate synthase
BRDCF_RS03740	COG0124	histidyl-tRNA synthetase
BRDCF_RS03760	COG1803	Methylglyoxal synthase
BRDCF_RS03770	COG0504	CTP synthase activity
BRDCF_RS03780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRDCF_RS03780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BRDCF_RS03785	COG0653	protein targeting
BRDCF_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRDCF_RS03800	COG0463	Glycosyl transferase, family 2
BRDCF_RS03810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BRDCF_RS03815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRDCF_RS03820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRDCF_RS03825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRDCF_RS03830	COG0681	Belongs to the peptidase S26 family
BRDCF_RS03835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRDCF_RS03840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRDCF_RS03845	COG0552	protein localization to endoplasmic reticulum
BRDCF_RS03855	COG0109	protoheme IX farnesyltransferase activity
BRDCF_RS03860	COG0148	phosphopyruvate hydratase activity
BRDCF_RS03865	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRDCF_RS03870	COG0556	nucleotide-excision repair
BRDCF_RS03875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRDCF_RS03890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRDCF_RS03905	COG0813	purine-nucleoside phosphorylase activity
BRDCF_RS03920	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BRDCF_RS03930	COG4821	SIS domain
BRDCF_RS03950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BRDCF_RS03960	COG1760	l-serine dehydratase
BRDCF_RS03965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BRDCF_RS03970	COG1061	Type III restriction enzyme res subunit
BRDCF_RS03980	COG1002	Type II restriction enzyme, methylase subunits
BRDCF_RS03985	COG0443	Heat shock 70 kDa protein
BRDCF_RS03990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRDCF_RS03995	COG0564	pseudouridine synthase activity
BRDCF_RS04000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRDCF_RS04005	COG0194	GDP metabolic process
BRDCF_RS04015	COG0191	fructose-bisphosphate aldolase activity
BRDCF_RS04025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BRDCF_RS04030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRDCF_RS04035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRDCF_RS04040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BRDCF_RS04045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRDCF_RS04050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BRDCF_RS04055	COG0356	it plays a direct role in the translocation of protons across the membrane
BRDCF_RS04065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BRDCF_RS04070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRDCF_RS04085	COG0493	'glutamate synthase
BRDCF_RS04090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRDCF_RS04100	COG0425	Belongs to the sulfur carrier protein TusA family
BRDCF_RS04105	COG2210	Belongs to the sulfur carrier protein TusA family
BRDCF_RS04115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRDCF_RS04120	COG0484	heat shock protein binding
BRDCF_RS04125	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BRDCF_RS04130	COG0335	large ribosomal subunit rRNA binding
BRDCF_RS04150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRDCF_RS04155	COG2226	methyltransferase
BRDCF_RS04170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BRDCF_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
BRDCF_RS04180	COG0156	8-amino-7-oxononanoate synthase activity
BRDCF_RS04185	COG0739	heme binding
BRDCF_RS04185	COG0741	lytic transglycosylase activity
BRDCF_RS04185	COG1196	nuclear chromosome segregation
BRDCF_RS04190	COG0187	DNA topoisomerase II activity
BRDCF_RS04205	COG2884	Cell division ATP-binding protein ftsE
BRDCF_RS04210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRDCF_RS04220	COG4974	Belongs to the 'phage' integrase family
BRDCF_RS04225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRDCF_RS04225	COG0519	Catalyzes the synthesis of GMP from XMP
BRDCF_RS04230	COG1217	gtp-binding protein TYPA
BRDCF_RS04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BRDCF_RS04245	COG0416	fatty acid biosynthetic process
BRDCF_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRDCF_RS04270	COG0513	Belongs to the DEAD box helicase family
BRDCF_RS04275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRDCF_RS04290	COG0574	Belongs to the PEP-utilizing enzyme family
BRDCF_RS04290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRDCF_RS04295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRDCF_RS04300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRDCF_RS04300	COG0047	phosphoribosylformylglycinamidine synthase activity
BRDCF_RS04325	COG4771	TonB-dependent receptor
BRDCF_RS04330	COG0702	epimerase
BRDCF_RS04335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BRDCF_RS04340	COG2195	Cleaves the N-terminal amino acid of tripeptides
BRDCF_RS04350	COG1288	antiporter activity
BRDCF_RS04360	COG4948	Mandelate Racemase Muconate Lactonizing
BRDCF_RS04365	COG0702	epimerase
BRDCF_RS04370	COG4771	TonB-dependent receptor
BRDCF_RS04380	COG0312	modulator of DNA gyrase
BRDCF_RS04425	COG4206	TonB-dependent receptor
BRDCF_RS04425	COG1629	transport
BRDCF_RS04475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BRDCF_RS04480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BRDCF_RS04495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BRDCF_RS04500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BRDCF_RS04505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRDCF_RS04510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRDCF_RS04540	COG1561	YicC-like family, N-terminal region
BRDCF_RS04545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRDCF_RS04550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BRDCF_RS04555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BRDCF_RS04560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRDCF_RS04565	COG0328	RNA-DNA hybrid ribonuclease activity
BRDCF_RS04570	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BRDCF_RS04575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BRDCF_RS04580	COG0166	Belongs to the GPI family
BRDCF_RS04590	COG1074	ATP-dependent DNA helicase activity
BRDCF_RS04600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BRDCF_RS04605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BRDCF_RS04610	COG0363	glucosamine-6-phosphate deaminase activity
BRDCF_RS04625	COG1979	alcohol dehydrogenase
BRDCF_RS04640	COG1970	mechanosensitive ion channel activity
BRDCF_RS04660	COG1126	abc transporter atp-binding protein
BRDCF_RS04670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRDCF_RS04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BRDCF_RS04685	COG3385	transposase activity
BRDCF_RS04705	COG0542	response to heat
BRDCF_RS04710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BRDCF_RS04720	COG4717	serine-type aminopeptidase activity
BRDCF_RS04725	COG0628	permease
BRDCF_RS04740	COG3385	transposase activity
BRDCF_RS04745	COG0658	competence protein
BRDCF_RS04750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BRDCF_RS04755	COG0280	phosphate acetyltransferase
BRDCF_RS04760	COG3426	butyrate kinase activity
BRDCF_RS04765	COG2081	HI0933 family
BRDCF_RS04780	COG0592	DNA-directed DNA polymerase activity
BRDCF_RS04785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRDCF_RS04790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BRDCF_RS04795	COG0339	signal peptide processing
BRDCF_RS04800	COG3263	regulation of cellular component size
BRDCF_RS04805	COG1115	amino acid carrier protein
BRDCF_RS04810	COG0018	arginyl-trna synthetase
BRDCF_RS04815	COG1032	radical SAM domain protein
BRDCF_RS04830	COG2183	response to ionizing radiation
BRDCF_RS04840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BRDCF_RS04845	COG0463	Glycosyl transferase, family 2
BRDCF_RS04870	COG1126	abc transporter atp-binding protein
BRDCF_RS04875	COG0765	amino acid transport
BRDCF_RS04885	COG1940	carbohydrate kinase activity
BRDCF_RS04900	COG1349	DNA-binding transcription factor activity
BRDCF_RS04905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BRDCF_RS04910	COG2271	Major facilitator Superfamily
BRDCF_RS04920	COG1629	transport
BRDCF_RS04920	COG4206	TonB-dependent receptor
BRDCF_RS04940	COG1446	asparaginase
BRDCF_RS04945	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BRDCF_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRDCF_RS04960	COG1418	mRNA catabolic process
BRDCF_RS05005	COG0402	S-adenosylhomocysteine deaminase activity
BRDCF_RS05010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRDCF_RS05020	COG1011	Hydrolase
BRDCF_RS05035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BRDCF_RS05040	COG0514	ATP-dependent DNA helicase (RecQ)
BRDCF_RS05045	COG0424	maF-like protein
BRDCF_RS05070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BRDCF_RS05075	COG2086	electron transfer activity
BRDCF_RS05085	COG0525	valine-tRNA ligase activity
BRDCF_RS05090	COG0824	Thioesterase
BRDCF_RS05095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BRDCF_RS05100	COG0805	protein transport
BRDCF_RS05105	COG0488	(ABC) transporter
BRDCF_RS05135	COG0363	glucosamine-6-phosphate deaminase activity
BRDCF_RS05140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRDCF_RS05145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRDCF_RS05150	COG3119	arylsulfatase activity
BRDCF_RS05155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BRDCF_RS05160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRDCF_RS05165	COG3177	Filamentation induced by cAMP protein fic
BRDCF_RS05190	COG1649	PFAM Uncharacterised BCR, COG1649
BRDCF_RS05195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BRDCF_RS05215	COG0205	6-phosphofructokinase activity
BRDCF_RS05220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BRDCF_RS05235	COG1295	ribonuclease BN
BRDCF_RS05235	COG1959	2 iron, 2 sulfur cluster binding
BRDCF_RS05245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRDCF_RS05260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BRDCF_RS05275	COG0505	Belongs to the CarA family
BRDCF_RS05280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRDCF_RS05325	COG0659	secondary active sulfate transmembrane transporter activity
BRDCF_RS05340	COG5012	cobalamin binding
BRDCF_RS05345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BRDCF_RS05350	COG1193	negative regulation of DNA recombination
BRDCF_RS05360	COG1509	lysine 2,3-aminomutase activity
BRDCF_RS05365	COG0604	alcohol dehydrogenase
BRDCF_RS05370	COG0604	alcohol dehydrogenase
BRDCF_RS05375	COG3246	L-lysine catabolic process to acetate
BRDCF_RS05380	COG1607	acyl-coa hydrolase
BRDCF_RS05395	COG1022	Amp-dependent synthetase and ligase
BRDCF_RS05405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BRDCF_RS05415	COG0167	dihydroorotate dehydrogenase activity
BRDCF_RS05420	COG1058	Belongs to the CinA family
BRDCF_RS05420	COG1546	Belongs to the CinA family
BRDCF_RS05430	COG4221	oxidoreductase activity
BRDCF_RS05455	COG1012	belongs to the aldehyde dehydrogenase family
BRDCF_RS05460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BRDCF_RS05470	COG3681	Belongs to the UPF0597 family
BRDCF_RS05485	COG0306	phosphate transporter
BRDCF_RS05490	COG0473	3-isopropylmalate dehydrogenase activity
BRDCF_RS05495	COG0066	3-isopropylmalate dehydratase activity
BRDCF_RS05500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRDCF_RS05505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BRDCF_RS05510	COG1024	Enoyl-CoA hydratase
BRDCF_RS05515	COG1250	3-hydroxyacyl-CoA dehydrogenase
BRDCF_RS05540	COG2205	protein histidine kinase activity
BRDCF_RS05540	COG4999	Histidine kinase
BRDCF_RS05540	COG3437	response regulator, receiver
BRDCF_RS05540	COG3850	Histidine kinase
BRDCF_RS05600	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BRDCF_RS05605	COG5002	protein histidine kinase activity
BRDCF_RS05605	COG0784	Response regulator, receiver
BRDCF_RS05615	COG1082	Xylose isomerase domain protein TIM barrel
BRDCF_RS05620	COG0366	Alpha amylase catalytic
BRDCF_RS05635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BRDCF_RS05640	COG4206	TonB-dependent receptor
BRDCF_RS05640	COG1629	transport
BRDCF_RS05660	COG0464	growth
BRDCF_RS05675	COG3385	transposase activity
BRDCF_RS05690	COG1484	DNA-dependent DNA replication
BRDCF_RS05695	COG4584	PFAM Integrase catalytic
BRDCF_RS05720	COG4372	Transposase
BRDCF_RS05740	COG4584	PFAM Integrase catalytic
BRDCF_RS05745	COG1484	DNA-dependent DNA replication
BRDCF_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
BRDCF_RS05760	COG0156	8-amino-7-oxononanoate synthase activity
BRDCF_RS05795	COG0586	Pfam SNARE associated Golgi protein
BRDCF_RS05810	COG0318	PFAM AMP-dependent synthetase and ligase
BRDCF_RS05815	COG0542	response to heat
BRDCF_RS05820	COG0602	queuosine metabolic process
BRDCF_RS05835	COG1183	phosphatidylcholine synthase activity
BRDCF_RS05845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRDCF_RS05865	COG1530	ribonuclease E activity
BRDCF_RS05870	COG0776	regulation of translation
BRDCF_RS05880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BRDCF_RS05885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BRDCF_RS05890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRDCF_RS05895	COG0706	membrane insertase activity
BRDCF_RS05900	COG1196	nuclear chromosome segregation
BRDCF_RS05905	COG0336	Belongs to the RNA methyltransferase TrmD family
BRDCF_RS05945	COG1131	(ABC) transporter
BRDCF_RS05955	COG1725	Transcriptional regulator
BRDCF_RS05965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRDCF_RS05970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRDCF_RS05980	COG0019	diaminopimelate decarboxylase activity
BRDCF_RS05985	COG1899	peptidyl-lysine modification to peptidyl-hypusine
BRDCF_RS05995	COG1595	DNA-templated transcription, initiation
BRDCF_RS06010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRDCF_RS06020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BRDCF_RS06030	COG0217	transcriptional regulatory protein
BRDCF_RS06035	COG0346	lactoylglutathione lyase activity
BRDCF_RS06040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BRDCF_RS06050	COG5016	pyruvate
BRDCF_RS06050	COG0511	ligase activity, forming carbon-carbon bonds
BRDCF_RS06055	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BRDCF_RS06070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BRDCF_RS06085	COG1269	ATP hydrolysis coupled proton transport
BRDCF_RS06095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRDCF_RS06100	COG3876	Protein conserved in bacteria
BRDCF_RS06110	COG0254	rRNA binding
BRDCF_RS06160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRDCF_RS06170	COG1131	(ABC) transporter
BRDCF_RS06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRDCF_RS06220	COG1216	Glycosyl transferase, family 2
BRDCF_RS06225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRDCF_RS06255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRDCF_RS06260	COG0824	Thioesterase
BRDCF_RS06280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRDCF_RS06285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRDCF_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
BRDCF_RS06315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRDCF_RS06325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRDCF_RS06340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BRDCF_RS06340	COG0321	lipoyl(octanoyl) transferase activity
BRDCF_RS06355	COG3279	Response regulator of the LytR AlgR family
BRDCF_RS06370	COG2267	carboxylic ester hydrolase activity
BRDCF_RS06390	COG2205	protein histidine kinase activity
BRDCF_RS06415	COG0346	lactoylglutathione lyase activity
BRDCF_RS06430	COG4206	TonB-dependent receptor
BRDCF_RS06430	COG1629	transport
BRDCF_RS06440	COG0482	sulfurtransferase activity
BRDCF_RS06445	COG0295	cytidine deaminase activity
BRDCF_RS06450	COG0791	NLP P60 protein
BRDCF_RS06450	COG1388	LysM domain
BRDCF_RS06455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRDCF_RS06460	COG0793	Belongs to the peptidase S41A family
BRDCF_RS06480	COG0598	Magnesium transport protein CorA
BRDCF_RS06490	COG1971	Probably functions as a manganese efflux pump
BRDCF_RS06495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRDCF_RS06500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BRDCF_RS06505	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BRDCF_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
BRDCF_RS06540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRDCF_RS06550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BRDCF_RS06555	COG0237	dephospho-CoA kinase activity
BRDCF_RS06565	COG1862	Preprotein translocase
BRDCF_RS06570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRDCF_RS06600	COG1956	GAF domain-containing protein
BRDCF_RS06605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BRDCF_RS06615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BRDCF_RS06620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRDCF_RS06635	COG0436	Aminotransferase
BRDCF_RS06645	COG0151	Belongs to the GarS family
BRDCF_RS06655	COG0402	S-adenosylhomocysteine deaminase activity
BRDCF_RS06660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRDCF_RS06660	COG0731	radical SAM domain protein
BRDCF_RS06665	COG1490	D-aminoacyl-tRNA deacylase activity
BRDCF_RS06670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BRDCF_RS06685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BRDCF_RS06715	COG1139	Iron-sulfur cluster binding protein
BRDCF_RS06720	COG0247	lactate metabolic process
BRDCF_RS06750	COG2814	Major facilitator Superfamily
BRDCF_RS06765	COG0702	epimerase
BRDCF_RS06770	COG4771	TonB-dependent receptor
BRDCF_RS06785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BRDCF_RS06790	COG0740	serine-type endopeptidase activity
BRDCF_RS06795	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRDCF_RS06805	COG2264	protein methyltransferase activity
BRDCF_RS06810	COG0149	triose-phosphate isomerase activity
BRDCF_RS06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRDCF_RS06825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRDCF_RS06825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRDCF_RS06835	COG0357	Ribosomal RNA small subunit methyltransferase G
BRDCF_RS06840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BRDCF_RS06845	COG2815	serine threonine protein kinase
BRDCF_RS06845	COG0515	serine threonine protein kinase
BRDCF_RS06850	COG0564	pseudouridine synthase activity
BRDCF_RS06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BRDCF_RS06865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BRDCF_RS06880	COG1703	isobutyryl-CoA mutase activity
BRDCF_RS06895	COG0251	oxidation-reduction process
BRDCF_RS06915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRDCF_RS06920	COG2195	Cleaves the N-terminal amino acid of tripeptides
BRDCF_RS06925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BRDCF_RS06930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BRDCF_RS06930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BRDCF_RS06940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRDCF_RS06945	COG4589	Belongs to the CDS family
BRDCF_RS06950	COG0688	phosphatidylethanolamine metabolic process
BRDCF_RS06955	COG0284	orotidine-5'-phosphate decarboxylase activity
BRDCF_RS06960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRDCF_RS06965	COG1151	hydroxylamine reductase activity
BRDCF_RS06995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRDCF_RS07000	COG0642	Histidine kinase
BRDCF_RS07035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRDCF_RS07040	COG3956	TIGRFAM MazG family protein
BRDCF_RS07050	COG0427	acetyl-CoA hydrolase
BRDCF_RS07115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BRDCF_RS07135	COG1122	ATPase activity
BRDCF_RS07140	COG0247	lactate metabolic process
BRDCF_RS07140	COG0277	FAD linked oxidase domain protein
BRDCF_RS07155	COG1902	pentaerythritol trinitrate reductase activity
BRDCF_RS07155	COG0446	pyridine nucleotide-disulphide oxidoreductase
BRDCF_RS07170	COG1805	sodium ion transport
BRDCF_RS07180	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BRDCF_RS07185	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BRDCF_RS07205	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BRDCF_RS07215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BRDCF_RS07220	COG0494	nUDIX hydrolase
BRDCF_RS07235	COG1674	ftsk spoiiie
BRDCF_RS07240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRDCF_RS07260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRDCF_RS07265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BRDCF_RS07280	COG0163	prenyltransferase activity
BRDCF_RS07285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRDCF_RS07300	COG0489	protein tyrosine kinase activity
BRDCF_RS07305	COG1086	Polysaccharide biosynthesis protein
BRDCF_RS07380	COG0438	transferase activity, transferring glycosyl groups
BRDCF_RS07400	COG0438	transferase activity, transferring glycosyl groups
BRDCF_RS07415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BRDCF_RS07420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRDCF_RS07440	COG4372	Transposase
BRDCF_RS07445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BRDCF_RS07490	COG1373	ATPase (AAA superfamily
BRDCF_RS07520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BRDCF_RS07535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRDCF_RS07540	COG0612	Peptidase, M16
BRDCF_RS07555	COG0811	peptide transport
BRDCF_RS07570	COG1136	(ABC) transporter
BRDCF_RS07570	COG0577	efflux transmembrane transporter activity
BRDCF_RS07575	COG1187	pseudouridine synthase activity
BRDCF_RS07580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BRDCF_RS07590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BRDCF_RS07595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BRDCF_RS07595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRDCF_RS07600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BRDCF_RS07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRDCF_RS07610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BRDCF_RS07615	COG0629	single-stranded DNA binding
BRDCF_RS07620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BRDCF_RS07635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRDCF_RS07640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BRDCF_RS07640	COG1918	ferrous iron import across plasma membrane
BRDCF_RS07665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BRDCF_RS07685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRDCF_RS07690	COG0081	regulation of translation
BRDCF_RS07695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRDCF_RS07700	COG0222	ribosome binding
BRDCF_RS07705	COG0085	RNA polymerase activity
BRDCF_RS07725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BRDCF_RS07730	COG0674	pyruvate-flavodoxin oxidoreductase activity
BRDCF_RS07730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BRDCF_RS07735	COG1013	pyruvate-flavodoxin oxidoreductase activity
BRDCF_RS07745	COG4771	TonB-dependent receptor
BRDCF_RS07765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BRDCF_RS07770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BRDCF_RS07790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BRDCF_RS07795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BRDCF_RS07800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRDCF_RS07815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BRDCF_RS07820	COG5632	N-Acetylmuramoyl-L-alanine amidase
BRDCF_RS07820	COG3409	Peptidoglycan-binding domain 1 protein
BRDCF_RS07825	COG0006	proline dipeptidase activity
BRDCF_RS07830	COG1592	Rubrerythrin
BRDCF_RS07835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BRDCF_RS07840	COG0492	ferredoxin-NADP+ reductase activity
BRDCF_RS07860	COG0497	DNA recombination
BRDCF_RS07865	COG0363	glucosamine-6-phosphate deaminase activity
BRDCF_RS07880	COG0386	Belongs to the glutathione peroxidase family
BRDCF_RS07885	COG4771	TonB-dependent receptor
BRDCF_RS07895	COG2197	response regulator
BRDCF_RS07930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BRDCF_RS07945	COG0612	Peptidase, M16
BRDCF_RS07955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BRDCF_RS07960	COG1137	ATPase activity
BRDCF_RS07970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BRDCF_RS07975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BRDCF_RS07975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BRDCF_RS07995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRDCF_RS08025	COG0640	Transcriptional regulator
BRDCF_RS08030	COG5658	integral membrane protein
BRDCF_RS08045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRDCF_RS08070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BRDCF_RS08075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BRDCF_RS08085	COG0495	leucyl-tRNA aminoacylation
BRDCF_RS08105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BRDCF_RS08120	COG1702	phosphate starvation-inducible protein PhoH
BRDCF_RS08125	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BRDCF_RS08130	COG1477	protein flavinylation
BRDCF_RS08165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BRDCF_RS08165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BRDCF_RS08170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BRDCF_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRDCF_RS08190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRDCF_RS08195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRDCF_RS08200	COG0180	Tryptophanyl-tRNA synthetase
BRDCF_RS08205	COG0358	DNA primase activity
BRDCF_RS08285	COG3645	SOS response
BRDCF_RS08305	COG1924	4 iron, 4 sulfur cluster binding
BRDCF_RS08320	COG2871	sodium ion transport
BRDCF_RS08365	COG4584	PFAM Integrase catalytic
BRDCF_RS08370	COG1484	DNA-dependent DNA replication
BRDCF_RS08400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BRDCF_RS08405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BRDCF_RS08415	COG3385	transposase activity
BRDCF_RS08425	COG0488	(ABC) transporter
BRDCF_RS08440	COG0433	COG0433 Predicted ATPase
BRDCF_RS08460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRDCF_RS08470	COG1366	Belongs to the anti-sigma-factor antagonist family
BRDCF_RS08505	COG1012	belongs to the aldehyde dehydrogenase family
BRDCF_RS08515	COG0823	Involved in the tonB-independent uptake of proteins
BRDCF_RS08515	COG4946	Tricorn protease homolog
BRDCF_RS08515	COG1506	peptidase
BRDCF_RS08520	COG0513	Belongs to the DEAD box helicase family
BRDCF_RS08575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRDCF_RS08605	COG4657	Part of a membrane complex involved in electron transport
BRDCF_RS08610	COG4660	Part of a membrane complex involved in electron transport
BRDCF_RS08615	COG4659	FMN binding
BRDCF_RS08620	COG4658	electron transport chain
BRDCF_RS08625	COG4656	Part of a membrane complex involved in electron transport
BRDCF_RS08630	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRDCF_RS08630	COG2878	Part of a membrane complex involved in electron transport
BRDCF_RS08645	COG0305	Participates in initiation and elongation during chromosome replication
BRDCF_RS08650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRDCF_RS08670	COG1388	LysM domain
BRDCF_RS08670	COG4942	peptidase
BRDCF_RS08675	COG0739	heme binding
BRDCF_RS08680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRDCF_RS08690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRDCF_RS08710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRDCF_RS08715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRDCF_RS08725	COG0343	queuine tRNA-ribosyltransferase activity
BRDCF_RS08730	COG2211	Major facilitator Superfamily
BRDCF_RS08745	COG0203	ribosomal protein L17
BRDCF_RS08750	COG0202	RNA polymerase activity
BRDCF_RS08755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRDCF_RS08760	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRDCF_RS08765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRDCF_RS08770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRDCF_RS08780	COG0201	protein transport
BRDCF_RS08785	COG0200	Binds to the 23S rRNA
BRDCF_RS08790	COG1841	ribosomal large subunit assembly
BRDCF_RS08795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRDCF_RS08800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRDCF_RS08805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BRDCF_RS08810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BRDCF_RS08815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRDCF_RS08820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRDCF_RS08825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRDCF_RS08830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRDCF_RS08835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRDCF_RS08840	COG0255	Belongs to the universal ribosomal protein uL29 family
BRDCF_RS08845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRDCF_RS08860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRDCF_RS08865	COG1968	undecaprenyl-diphosphatase activity
BRDCF_RS08875	COG2177	Part of the ABC transporter FtsEX involved in
BRDCF_RS08880	COG0297	glycogen (starch) synthase activity
BRDCF_RS08890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRDCF_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRDCF_RS08905	COG1473	amidohydrolase
BRDCF_RS08920	COG3682	Transcriptional regulator
BRDCF_RS08925	COG0823	Involved in the tonB-independent uptake of proteins
BRDCF_RS08925	COG1506	peptidase
BRDCF_RS08955	COG1629	transport
BRDCF_RS08955	COG4206	TonB-dependent receptor
BRDCF_RS09005	COG0215	cysteine-tRNA ligase activity
BRDCF_RS09010	COG0629	single-stranded DNA binding
BRDCF_RS09025	COG0339	signal peptide processing
BRDCF_RS09045	COG1342	Belongs to the UPF0251 family
BRDCF_RS09050	COG3591	Belongs to the peptidase S1B family
BRDCF_RS09060	COG3591	Belongs to the peptidase S1B family
BRDCF_RS09065	COG0612	Peptidase, M16
BRDCF_RS09075	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BRDCF_RS09130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRDCF_RS09135	COG2226	methyltransferase
BRDCF_RS09140	COG0798	PFAM Bile acid sodium symporter
BRDCF_RS09145	COG4221	oxidoreductase activity
BRDCF_RS09165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRDCF_RS09200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BRDCF_RS09205	COG0259	pyridoxamine-phosphate oxidase activity
BRDCF_RS09220	COG2814	Major facilitator Superfamily
BRDCF_RS09250	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BRDCF_RS09280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRDCF_RS09290	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BRDCF_RS09300	COG4124	Belongs to the glycosyl hydrolase 26 family
BRDCF_RS09320	COG3119	arylsulfatase activity
BRDCF_RS09325	COG0641	radical SAM
BRDCF_RS09340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BRDCF_RS09410	COG2954	triphosphatase activity
BRDCF_RS09415	COG0471	metal ion transport
BRDCF_RS09445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRDCF_RS09455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRDCF_RS09460	COG2031	fatty acid transporter
BRDCF_RS09470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BRDCF_RS09485	COG0516	GMP reductase activity
BRDCF_RS09515	COG3647	Membrane
BRDCF_RS09540	COG1741	Belongs to the pirin family
BRDCF_RS09555	COG1335	isochorismatase
BRDCF_RS09560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BRDCF_RS09600	COG2801	Transposase and inactivated derivatives
BRDCF_RS09605	COG2963	transposase activity
BRDCF_RS09635	COG4584	PFAM Integrase catalytic
BRDCF_RS09640	COG1484	DNA-dependent DNA replication
BRDCF_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS09710	COG1309	transcriptional regulator
BRDCF_RS09755	COG2390	Transcriptional regulator
BRDCF_RS09755	COG4584	PFAM Integrase catalytic
BRDCF_RS09760	COG1484	DNA-dependent DNA replication
BRDCF_RS09765	COG4974	Belongs to the 'phage' integrase family
BRDCF_RS09790	COG0517	IMP dehydrogenase activity
BRDCF_RS09835	COG3391	amine dehydrogenase activity
BRDCF_RS09840	COG5002	protein histidine kinase activity
BRDCF_RS09845	COG0745	RESPONSE REGULATOR receiver
BRDCF_RS09860	COG1715	Restriction endonuclease
BRDCF_RS09910	COG4974	Belongs to the 'phage' integrase family
BRDCF_RS09925	COG5002	protein histidine kinase activity
BRDCF_RS09930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRDCF_RS09940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRDCF_RS09955	COG0009	L-threonylcarbamoyladenylate synthase
BRDCF_RS09960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRDCF_RS09980	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BRDCF_RS09990	COG0709	Synthesizes selenophosphate from selenide and ATP
BRDCF_RS09995	COG3876	Protein conserved in bacteria
BRDCF_RS10000	COG0802	atpase or kinase
BRDCF_RS10030	COG0606	chelatase, subunit chli
BRDCF_RS10035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BRDCF_RS10040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRDCF_RS10045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRDCF_RS10055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BRDCF_RS10060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BRDCF_RS10070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BRDCF_RS10075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BRDCF_RS10080	COG0089	rRNA binding
BRDCF_RS10085	COG0088	Forms part of the polypeptide exit tunnel
BRDCF_RS10090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BRDCF_RS10120	COG0626	cystathionine gamma-synthase activity
BRDCF_RS10125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BRDCF_RS10160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BRDCF_RS10165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BRDCF_RS10205	COG3550	peptidyl-serine autophosphorylation
BRDCF_RS10215	COG1396	sequence-specific DNA binding
BRDCF_RS10240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRDCF_RS10245	COG2235	arginine
BRDCF_RS10255	COG0792	nuclease activity
BRDCF_RS10265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRDCF_RS10275	COG0826	peptidase U32
BRDCF_RS10295	COG1162	GTPase activity
BRDCF_RS10310	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BRDCF_RS10320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRDCF_RS10325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRDCF_RS10330	COG0049	tRNA binding
BRDCF_RS10335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BRDCF_RS10340	COG0051	transcription antitermination factor activity, RNA binding
BRDCF_RS10370	COG0415	Belongs to the DNA photolyase family
BRDCF_RS10375	COG0318	PFAM AMP-dependent synthetase and ligase
BRDCF_RS10375	COG0204	Acyl-transferase
BRDCF_RS10385	COG1301	dicarboxylic acid transport
BRDCF_RS10390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BRDCF_RS10405	COG0649	NAD binding
BRDCF_RS10410	COG0651	ATP synthesis coupled electron transport
BRDCF_RS10425	COG0651	ATP synthesis coupled electron transport
BRDCF_RS10445	COG1129	ABC transporter
BRDCF_RS10445	COG0842	Transport permease protein
BRDCF_RS10450	COG0842	Transport permease protein
BRDCF_RS10455	COG1131	(ABC) transporter
BRDCF_RS10460	COG1131	(ABC) transporter
BRDCF_RS10465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS10485	COG1216	Glycosyl transferase, family 2
BRDCF_RS10495	COG0438	transferase activity, transferring glycosyl groups
BRDCF_RS10510	COG1215	transferase activity, transferring glycosyl groups
BRDCF_RS10525	COG0438	transferase activity, transferring glycosyl groups
BRDCF_RS10535	COG0438	transferase activity, transferring glycosyl groups
BRDCF_RS10570	COG2205	protein histidine kinase activity
BRDCF_RS10570	COG0745	RESPONSE REGULATOR receiver
BRDCF_RS10570	COG3292	Two component regulator propeller
BRDCF_RS10610	COG2204	response regulator
BRDCF_RS10630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BRDCF_RS10645	COG2920	part of a sulfur-relay system
BRDCF_RS10650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRDCF_RS10650	COG0140	phosphoribosyl-ATP diphosphatase activity
BRDCF_RS10655	COG0107	imidazoleglycerol-phosphate synthase activity
BRDCF_RS10660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRDCF_RS10665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BRDCF_RS10670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BRDCF_RS10680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRDCF_RS10685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BRDCF_RS10695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BRDCF_RS10700	COG3005	denitrification pathway
BRDCF_RS10715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BRDCF_RS10725	COG1193	negative regulation of DNA recombination
BRDCF_RS10730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BRDCF_RS10740	COG0793	Belongs to the peptidase S41A family
BRDCF_RS10745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BRDCF_RS10750	COG1381	Involved in DNA repair and RecF pathway recombination
BRDCF_RS10785	COG0594	ribonuclease P activity
BRDCF_RS10795	COG0322	excinuclease ABC activity
BRDCF_RS10810	COG1283	sodium-dependent phosphate transmembrane transporter activity
BRDCF_RS10835	COG1238	metal cluster binding
BRDCF_RS10840	COG0590	tRNA wobble adenosine to inosine editing
BRDCF_RS10845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRDCF_RS10880	COG3621	Patatin-like phospholipase
BRDCF_RS10885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRDCF_RS10910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BRDCF_RS10915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BRDCF_RS10925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BRDCF_RS10940	COG0719	Fe-S assembly protein
BRDCF_RS10945	COG0396	ATPase activity
BRDCF_RS10955	COG0719	Fe-S assembly protein
BRDCF_RS10970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BRDCF_RS10975	COG0557	exoribonuclease II activity
BRDCF_RS10985	COG2373	Large extracellular alpha-helical protein
BRDCF_RS11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS11015	COG3033	Beta-eliminating lyase
BRDCF_RS11020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRDCF_RS11035	COG4864	UPF0365 protein
BRDCF_RS11045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BRDCF_RS11055	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BRDCF_RS11100	COG4372	Transposase
BRDCF_RS11135	COG0246	Mannitol dehydrogenase
BRDCF_RS11145	COG1063	alcohol dehydrogenase
BRDCF_RS11155	COG2801	Transposase and inactivated derivatives
BRDCF_RS11160	COG2963	transposase activity
BRDCF_RS11225	COG2357	RelA SpoT domain protein
BRDCF_RS11230	COG1629	transport
BRDCF_RS11230	COG4206	TonB-dependent receptor
BRDCF_RS11235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BRDCF_RS11250	COG0575	Belongs to the CDS family
BRDCF_RS11275	COG0730	response to heat
BRDCF_RS11305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRDCF_RS11325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BRDCF_RS11345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BRDCF_RS11360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BRDCF_RS11365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BRDCF_RS11370	COG1120	ATPase activity
BRDCF_RS11375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BRDCF_RS11380	COG0588	phosphoglycerate mutase activity
BRDCF_RS11400	COG0577	efflux transmembrane transporter activity
BRDCF_RS11405	COG1136	(ABC) transporter
BRDCF_RS11445	COG0167	dihydroorotate dehydrogenase activity
BRDCF_RS11450	COG0423	glycine-tRNA ligase activity
BRDCF_RS11465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRDCF_RS11470	COG2151	metal-sulfur cluster biosynthetic enzyme
BRDCF_RS11475	COG2166	iron-sulfur cluster assembly
BRDCF_RS11485	COG0632	four-way junction helicase activity
BRDCF_RS11490	COG0509	glycine decarboxylation via glycine cleavage system
BRDCF_RS11500	COG1022	Amp-dependent synthetase and ligase
BRDCF_RS11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRDCF_RS11565	COG0494	nUDIX hydrolase
BRDCF_RS11615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BRDCF_RS11620	COG2205	protein histidine kinase activity
BRDCF_RS11635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRDCF_RS11640	COG5002	protein histidine kinase activity
BRDCF_RS11640	COG0784	Response regulator, receiver
BRDCF_RS11640	COG2205	protein histidine kinase activity
BRDCF_RS11650	COG4251	negative regulation of phosphorylation
BRDCF_RS11665	COG1846	Transcriptional regulator
BRDCF_RS11675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BRDCF_RS11680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRDCF_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BRDCF_RS11700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BRDCF_RS11705	COG5492	domain, Protein
BRDCF_RS11715	COG0784	Response regulator, receiver
BRDCF_RS11715	COG2198	Histidine kinase
BRDCF_RS11715	COG5002	protein histidine kinase activity
BRDCF_RS11720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRDCF_RS11730	COG3275	phosphorelay sensor kinase activity
BRDCF_RS11755	COG0545	Peptidyl-prolyl cis-trans isomerase
BRDCF_RS11760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRDCF_RS11760	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BRDCF_RS11765	COG1086	Polysaccharide biosynthesis protein
BRDCF_RS11775	COG3118	belongs to the thioredoxin family
BRDCF_RS11780	COG4948	Mandelate Racemase Muconate Lactonizing
BRDCF_RS11790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BRDCF_RS11800	COG2234	aminopeptidase activity
BRDCF_RS11855	COG5002	protein histidine kinase activity
BRDCF_RS11855	COG2198	Histidine kinase
BRDCF_RS11855	COG0784	Response regulator, receiver