locus-tag	class	description
INE72_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE72_RS00010	COG0778	Nitroreductase
INE72_RS00020	COG1640	4-alpha-glucanotransferase
INE72_RS00025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE72_RS00045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE72_RS00050	COG1022	Amp-dependent synthetase and ligase
INE72_RS00085	COG0359	binds to the 23S rRNA
INE72_RS00090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE72_RS00095	COG0360	Binds together with S18 to 16S ribosomal RNA
INE72_RS00120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE72_RS00125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE72_RS00150	COG1131	(ABC) transporter
INE72_RS00160	COG2431	L-lysine efflux transmembrane transporter activity
INE72_RS00180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE72_RS00185	COG4771	TonB-dependent receptor
INE72_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE72_RS00220	COG0802	atpase or kinase
INE72_RS00235	COG0714	Associated with various cellular activities
INE72_RS00270	COG3118	belongs to the thioredoxin family
INE72_RS00280	COG0688	phosphatidylethanolamine metabolic process
INE72_RS00285	COG1183	phosphatidylcholine synthase activity
INE72_RS00305	COG0792	nuclease activity
INE72_RS00330	COG0534	Mate efflux family protein
INE72_RS00335	COG0528	UMP kinase activity
INE72_RS00345	COG0233	cytoplasmic translational termination
INE72_RS00350	COG1162	GTPase activity
INE72_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE72_RS00375	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE72_RS00375	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE72_RS00385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE72_RS00400	COG1629	transport
INE72_RS00410	COG4206	TonB-dependent receptor
INE72_RS00410	COG1629	transport
INE72_RS00420	COG2095	MarC family integral membrane protein
INE72_RS00435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE72_RS00445	COG1785	Belongs to the alkaline phosphatase family
INE72_RS00455	COG1629	transport
INE72_RS00455	COG4206	TonB-dependent receptor
INE72_RS00460	COG1435	thymidine kinase activity
INE72_RS00465	COG0628	permease
INE72_RS00495	COG0702	epimerase
INE72_RS00500	COG4771	TonB-dependent receptor
INE72_RS00505	COG3292	Two component regulator propeller
INE72_RS00505	COG0745	RESPONSE REGULATOR receiver
INE72_RS00505	COG2205	protein histidine kinase activity
INE72_RS00540	COG0589	response to stress
INE72_RS00540	COG0475	glutathione-regulated potassium exporter activity
INE72_RS00555	COG3292	Two component regulator propeller
INE72_RS00555	COG0745	RESPONSE REGULATOR receiver
INE72_RS00555	COG2205	protein histidine kinase activity
INE72_RS00560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE72_RS00565	COG4771	TonB-dependent receptor
INE72_RS00645	COG0534	Mate efflux family protein
INE72_RS00660	COG0826	peptidase U32
INE72_RS00665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
INE72_RS00675	COG0436	Aminotransferase
INE72_RS00680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE72_RS00745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE72_RS00785	COG2433	Pfam Transposase IS66
INE72_RS00795	COG4974	Belongs to the 'phage' integrase family
INE72_RS00815	COG4206	TonB-dependent receptor
INE72_RS00815	COG1629	transport
INE72_RS00820	COG0702	epimerase
INE72_RS00825	COG3250	beta-galactosidase activity
INE72_RS00830	COG3420	alginic acid biosynthetic process
INE72_RS00835	COG0519	Catalyzes the synthesis of GMP from XMP
INE72_RS00840	COG5002	protein histidine kinase activity
INE72_RS00845	COG2205	protein histidine kinase activity
INE72_RS00855	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
INE72_RS00865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE72_RS00875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
INE72_RS00915	COG2204	response regulator
INE72_RS00920	COG0446	pyridine nucleotide-disulphide oxidoreductase
INE72_RS00940	COG1472	Belongs to the glycosyl hydrolase 3 family
INE72_RS00945	COG0737	Belongs to the 5'-nucleotidase family
INE72_RS00955	COG0335	large ribosomal subunit rRNA binding
INE72_RS00960	COG1940	carbohydrate kinase activity
INE72_RS00965	COG1136	(ABC) transporter
INE72_RS00965	COG0577	efflux transmembrane transporter activity
INE72_RS00970	COG1136	(ABC) transporter
INE72_RS00970	COG0577	efflux transmembrane transporter activity
INE72_RS00975	COG0577	efflux transmembrane transporter activity
INE72_RS00975	COG1136	(ABC) transporter
INE72_RS00990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE72_RS00990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE72_RS00995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE72_RS01015	COG2996	Protein conserved in bacteria
INE72_RS01020	COG0039	L-malate dehydrogenase activity
INE72_RS01030	COG2217	Heavy metal translocating P-type atpase
INE72_RS01040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INE72_RS01045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE72_RS01050	COG0509	glycine decarboxylation via glycine cleavage system
INE72_RS01065	COG0006	proline dipeptidase activity
INE72_RS01080	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE72_RS01090	COG1773	rubredoxin
INE72_RS01100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE72_RS01105	COG1011	Hydrolase
INE72_RS01110	COG0196	riboflavin kinase activity
INE72_RS01115	COG1266	CAAX protease self-immunity
INE72_RS01125	COG0612	Peptidase, M16
INE72_RS01140	COG1629	transport
INE72_RS01140	COG4206	TonB-dependent receptor
INE72_RS01145	COG2166	iron-sulfur cluster assembly
INE72_RS01150	COG2234	aminopeptidase activity
INE72_RS01155	COG1619	proteins homologs of microcin C7 resistance protein MccF
INE72_RS01165	COG0280	phosphate acetyltransferase
INE72_RS01170	COG3426	butyrate kinase activity
INE72_RS01190	COG1185	polyribonucleotide nucleotidyltransferase activity
INE72_RS01200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE72_RS01225	COG0076	glutamate decarboxylase activity
INE72_RS01230	COG2066	Belongs to the glutaminase family
INE72_RS01240	COG0531	amino acid
INE72_RS01370	COG4974	Belongs to the 'phage' integrase family
INE72_RS01375	COG4974	Belongs to the 'phage' integrase family
INE72_RS01380	COG4974	Belongs to the 'phage' integrase family
INE72_RS01470	COG0745	RESPONSE REGULATOR receiver
INE72_RS01470	COG3292	Two component regulator propeller
INE72_RS01470	COG2205	protein histidine kinase activity
INE72_RS01470	COG0745	RESPONSE REGULATOR receiver
INE72_RS01470	COG3292	Two component regulator propeller
INE72_RS01470	COG2205	protein histidine kinase activity
INE72_RS01485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INE72_RS01500	COG3546	catalase activity
INE72_RS01565	COG1192	Involved in chromosome partitioning
INE72_RS01700	COG0542	response to heat
INE72_RS01730	COG3209	COG3209 Rhs family protein
INE72_RS01805	COG2205	protein histidine kinase activity
INE72_RS01805	COG0784	Response regulator, receiver
INE72_RS01805	COG2198	Histidine kinase
INE72_RS01805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE72_RS01875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE72_RS01915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INE72_RS01990	COG1725	Transcriptional regulator
INE72_RS02000	COG1131	(ABC) transporter
INE72_RS02070	COG0673	inositol 2-dehydrogenase activity
INE72_RS02085	COG3420	alginic acid biosynthetic process
INE72_RS02100	COG0702	epimerase
INE72_RS02105	COG4771	TonB-dependent receptor
INE72_RS02120	COG0667	Aldo Keto reductase
INE72_RS02125	COG1696	Membrane protein involved in D-alanine export
INE72_RS02160	COG1309	transcriptional regulator
INE72_RS02190	COG0203	ribosomal protein L17
INE72_RS02195	COG0202	RNA polymerase activity
INE72_RS02200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE72_RS02205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE72_RS02210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE72_RS02215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE72_RS02220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE72_RS02235	COG0200	Binds to the 23S rRNA
INE72_RS02240	COG1841	ribosomal large subunit assembly
INE72_RS02245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE72_RS02250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE72_RS02255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE72_RS02260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE72_RS02265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE72_RS02270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE72_RS02275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE72_RS02280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE72_RS02285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE72_RS02290	COG0255	Belongs to the universal ribosomal protein uL29 family
INE72_RS02295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE72_RS02300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE72_RS02305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INE72_RS02310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE72_RS02315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE72_RS02320	COG0089	rRNA binding
INE72_RS02325	COG0088	Forms part of the polypeptide exit tunnel
INE72_RS02330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE72_RS02335	COG0051	transcription antitermination factor activity, RNA binding
INE72_RS02340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE72_RS02345	COG0049	tRNA binding
INE72_RS02350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE72_RS02360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE72_RS02365	COG0085	RNA polymerase activity
INE72_RS02370	COG0222	ribosome binding
INE72_RS02375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE72_RS02380	COG0081	regulation of translation
INE72_RS02385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE72_RS02395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INE72_RS02405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INE72_RS02435	COG4974	Belongs to the 'phage' integrase family
INE72_RS02440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE72_RS02445	COG0006	proline dipeptidase activity
INE72_RS02450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE72_RS02460	COG3118	belongs to the thioredoxin family
INE72_RS02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE72_RS02480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE72_RS02490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE72_RS02505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE72_RS02510	COG1027	Aspartate ammonia-lyase
INE72_RS02515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE72_RS02520	COG0252	asparaginase activity
INE72_RS02545	COG4771	TonB-dependent receptor
INE72_RS02560	COG3119	arylsulfatase activity
INE72_RS02570	COG2096	Adenosyltransferase
INE72_RS02610	COG1051	belongs to the nudix hydrolase family
INE72_RS02615	COG0546	phosphoglycolate phosphatase activity
INE72_RS02640	COG0662	Cupin 2, conserved barrel domain protein
INE72_RS02640	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE72_RS02645	COG0318	PFAM AMP-dependent synthetase and ligase
INE72_RS02650	COG1396	sequence-specific DNA binding
INE72_RS02655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE72_RS02660	COG1217	gtp-binding protein TYPA
INE72_RS02675	COG2059	Chromate
INE72_RS02685	COG5434	Belongs to the glycosyl hydrolase 28 family
INE72_RS02705	COG1629	transport
INE72_RS02735	COG1595	DNA-templated transcription, initiation
INE72_RS02740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE72_RS02745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE72_RS02775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
INE72_RS02785	COG0793	Belongs to the peptidase S41A family
INE72_RS02790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE72_RS02825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE72_RS02830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE72_RS02840	COG1629	transport
INE72_RS02845	COG0702	epimerase
INE72_RS02870	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS02880	COG3634	alkyl hydroperoxide reductase activity
INE72_RS02890	COG1629	transport
INE72_RS02895	COG0702	epimerase
INE72_RS02905	COG3292	Two component regulator propeller
INE72_RS02905	COG0745	RESPONSE REGULATOR receiver
INE72_RS02905	COG2205	protein histidine kinase activity
INE72_RS02910	COG1501	Belongs to the glycosyl hydrolase 31 family
INE72_RS02920	COG2816	NAD+ diphosphatase activity
INE72_RS02940	COG1629	transport
INE72_RS02950	COG4771	TonB-dependent receptor
INE72_RS02975	COG0745	RESPONSE REGULATOR receiver
INE72_RS02975	COG2205	protein histidine kinase activity
INE72_RS02975	COG3292	Two component regulator propeller
INE72_RS02975	COG3292	Two component regulator propeller
INE72_RS02975	COG2205	protein histidine kinase activity
INE72_RS02975	COG0745	RESPONSE REGULATOR receiver
INE72_RS03005	COG4974	Belongs to the 'phage' integrase family
INE72_RS03010	COG4974	Belongs to the 'phage' integrase family
INE72_RS03015	COG4974	Belongs to the 'phage' integrase family
INE72_RS03120	COG1192	Involved in chromosome partitioning
INE72_RS03245	COG2198	Histidine kinase
INE72_RS03245	COG0784	Response regulator, receiver
INE72_RS03245	COG2205	protein histidine kinase activity
INE72_RS03310	COG0739	heme binding
INE72_RS03365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS03365	COG0551	DNA topoisomerase type I activity
INE72_RS03385	COG4974	Belongs to the 'phage' integrase family
INE72_RS03400	COG0018	arginyl-trna synthetase
INE72_RS03410	COG0705	Rhomboid family
INE72_RS03425	COG0339	signal peptide processing
INE72_RS03430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE72_RS03440	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE72_RS03440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE72_RS03445	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE72_RS03460	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE72_RS03465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE72_RS03485	COG4974	Belongs to the 'phage' integrase family
INE72_RS03540	COG0582	viral genome integration into host DNA
INE72_RS03635	COG3940	Belongs to the glycosyl hydrolase 43 family
INE72_RS03640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS03645	COG3119	arylsulfatase activity
INE72_RS03665	COG4771	TonB-dependent receptor
INE72_RS03675	COG3250	beta-galactosidase activity
INE72_RS03690	COG0702	epimerase
INE72_RS03695	COG4206	TonB-dependent receptor
INE72_RS03695	COG1629	transport
INE72_RS03700	COG3292	Two component regulator propeller
INE72_RS03700	COG2205	protein histidine kinase activity
INE72_RS03700	COG0745	RESPONSE REGULATOR receiver
INE72_RS03730	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS03770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE72_RS03770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE72_RS03790	COG3475	LICD family
INE72_RS03805	COG0438	transferase activity, transferring glycosyl groups
INE72_RS03820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS03885	COG3250	beta-galactosidase activity
INE72_RS03905	COG1629	transport
INE72_RS03910	COG3250	beta-galactosidase activity
INE72_RS03920	COG3292	Two component regulator propeller
INE72_RS03920	COG2205	protein histidine kinase activity
INE72_RS03920	COG0745	RESPONSE REGULATOR receiver
INE72_RS03940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE72_RS03945	COG0545	Peptidyl-prolyl cis-trans isomerase
INE72_RS03950	COG0545	Peptidyl-prolyl cis-trans isomerase
INE72_RS03975	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE72_RS04015	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE72_RS04020	COG4771	TonB-dependent receptor
INE72_RS04060	COG4974	Belongs to the 'phage' integrase family
INE72_RS04065	COG0732	type I restriction modification DNA specificity domain
INE72_RS04090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INE72_RS04110	COG4771	TonB-dependent receptor
INE72_RS04115	COG0702	epimerase
INE72_RS04120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE72_RS04145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE72_RS04150	COG3409	Peptidoglycan-binding domain 1 protein
INE72_RS04150	COG0793	Belongs to the peptidase S41A family
INE72_RS04160	COG3119	arylsulfatase activity
INE72_RS04175	COG1053	succinate dehydrogenase
INE72_RS04180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE72_RS04200	COG0745	RESPONSE REGULATOR receiver
INE72_RS04200	COG2205	protein histidine kinase activity
INE72_RS04200	COG3292	Two component regulator propeller
INE72_RS04205	COG4771	TonB-dependent receptor
INE72_RS04245	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS04285	COG3119	arylsulfatase activity
INE72_RS04295	COG3119	arylsulfatase activity
INE72_RS04300	COG3119	arylsulfatase activity
INE72_RS04310	COG0702	epimerase
INE72_RS04315	COG1629	transport
INE72_RS04325	COG2433	Pfam Transposase IS66
INE72_RS04345	COG2205	protein histidine kinase activity
INE72_RS04345	COG3292	Two component regulator propeller
INE72_RS04345	COG0745	RESPONSE REGULATOR receiver
INE72_RS04350	COG3119	arylsulfatase activity
INE72_RS04360	COG0582	viral genome integration into host DNA
INE72_RS04415	COG0702	epimerase
INE72_RS04420	COG4771	TonB-dependent receptor
INE72_RS04435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE72_RS04435	COG0758	DNA mediated transformation
INE72_RS04445	COG0826	peptidase U32
INE72_RS04450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE72_RS04465	COG0557	exoribonuclease II activity
INE72_RS04475	COG1472	Belongs to the glycosyl hydrolase 3 family
INE72_RS04490	COG1917	Cupin 2, conserved barrel domain protein
INE72_RS04495	COG1073	alpha beta
INE72_RS04500	COG2814	Major facilitator Superfamily
INE72_RS04505	COG1012	belongs to the aldehyde dehydrogenase family
INE72_RS04510	COG0012	GTP binding
INE72_RS04515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
INE72_RS04520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE72_RS04525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE72_RS04535	COG3250	beta-galactosidase activity
INE72_RS04550	COG1629	transport
INE72_RS04550	COG4206	TonB-dependent receptor
INE72_RS04565	COG0697	spore germination
INE72_RS04570	COG0495	leucyl-tRNA aminoacylation
INE72_RS04575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE72_RS04580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INE72_RS04585	COG1360	Flagellar Motor Protein
INE72_RS04595	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS04605	COG0745	RESPONSE REGULATOR receiver
INE72_RS04605	COG2205	protein histidine kinase activity
INE72_RS04605	COG3292	Two component regulator propeller
INE72_RS04630	COG4771	TonB-dependent receptor
INE72_RS04635	COG0561	phosphatase activity
INE72_RS04640	COG4771	TonB-dependent receptor
INE72_RS04655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE72_RS04685	COG4206	TonB-dependent receptor
INE72_RS04685	COG1629	transport
INE72_RS04710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS04720	COG0731	radical SAM domain protein
INE72_RS04720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE72_RS04735	COG4771	TonB-dependent receptor
INE72_RS04780	COG1629	transport
INE72_RS04800	COG3119	arylsulfatase activity
INE72_RS04805	COG3119	arylsulfatase activity
INE72_RS04810	COG3119	arylsulfatase activity
INE72_RS04815	COG3119	arylsulfatase activity
INE72_RS04825	COG3119	arylsulfatase activity
INE72_RS04835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INE72_RS04840	COG0659	secondary active sulfate transmembrane transporter activity
INE72_RS04845	COG1592	Rubrerythrin
INE72_RS04890	COG0427	acetyl-CoA hydrolase
INE72_RS04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE72_RS04990	COG2177	Part of the ABC transporter FtsEX involved in
INE72_RS05000	COG1968	undecaprenyl-diphosphatase activity
INE72_RS05005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE72_RS05010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE72_RS05015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE72_RS05025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE72_RS05055	COG0594	ribonuclease P activity
INE72_RS05060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE72_RS05065	COG0084	hydrolase, TatD family'
INE72_RS05070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INE72_RS05080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE72_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
INE72_RS05145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE72_RS05160	COG1121	(ABC) transporter
INE72_RS05170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
INE72_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INE72_RS05195	COG0823	Involved in the tonB-independent uptake of proteins
INE72_RS05195	COG1506	peptidase
INE72_RS05200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE72_RS05200	COG0116	Belongs to the methyltransferase superfamily
INE72_RS05205	COG1045	serine acetyltransferase
INE72_RS05210	COG3275	phosphorelay sensor kinase activity
INE72_RS05215	COG3279	Response regulator of the LytR AlgR family
INE72_RS05225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE72_RS05225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE72_RS05230	COG0142	geranyltranstransferase activity
INE72_RS05240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INE72_RS05245	COG1694	Mazg nucleotide pyrophosphohydrolase
INE72_RS05250	COG1490	D-aminoacyl-tRNA deacylase activity
INE72_RS05255	COG0322	excinuclease ABC activity
INE72_RS05260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE72_RS05265	COG0445	tRNA wobble uridine modification
INE72_RS05285	COG4771	TonB-dependent receptor
INE72_RS05330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE72_RS05350	COG2715	membrane protein required for spore maturation
INE72_RS05355	COG2255	four-way junction helicase activity
INE72_RS05360	COG2852	Protein conserved in bacteria
INE72_RS05375	COG3591	Belongs to the peptidase S1B family
INE72_RS05380	COG0513	Belongs to the DEAD box helicase family
INE72_RS05400	COG0612	Peptidase, M16
INE72_RS05410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS05415	COG1629	transport
INE72_RS05440	COG0673	inositol 2-dehydrogenase activity
INE72_RS05445	COG3292	Two component regulator propeller
INE72_RS05445	COG2205	protein histidine kinase activity
INE72_RS05445	COG0745	RESPONSE REGULATOR receiver
INE72_RS05455	COG0681	Belongs to the peptidase S26 family
INE72_RS05465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE72_RS05475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS05490	COG5492	domain, Protein
INE72_RS05500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE72_RS05505	COG4771	TonB-dependent receptor
INE72_RS05540	COG3119	arylsulfatase activity
INE72_RS05545	COG0745	RESPONSE REGULATOR receiver
INE72_RS05545	COG2205	protein histidine kinase activity
INE72_RS05545	COG3292	Two component regulator propeller
INE72_RS05545	COG0745	RESPONSE REGULATOR receiver
INE72_RS05545	COG2205	protein histidine kinase activity
INE72_RS05545	COG3292	Two component regulator propeller
INE72_RS05555	COG3250	beta-galactosidase activity
INE72_RS05570	COG0702	epimerase
INE72_RS05575	COG4206	TonB-dependent receptor
INE72_RS05575	COG1629	transport
INE72_RS05580	COG2205	protein histidine kinase activity
INE72_RS05580	COG3292	Two component regulator propeller
INE72_RS05580	COG0745	RESPONSE REGULATOR receiver
INE72_RS05580	COG2205	protein histidine kinase activity
INE72_RS05580	COG0745	RESPONSE REGULATOR receiver
INE72_RS05580	COG3292	Two component regulator propeller
INE72_RS05590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE72_RS05595	COG1538	Outer membrane efflux protein
INE72_RS05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS05610	COG3250	beta-galactosidase activity
INE72_RS05615	COG4771	TonB-dependent receptor
INE72_RS05625	COG4206	TonB-dependent receptor
INE72_RS05625	COG1629	transport
INE72_RS05630	COG0702	epimerase
INE72_RS05650	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS05655	COG3119	arylsulfatase activity
INE72_RS05660	COG5492	domain, Protein
INE72_RS05665	COG0215	cysteine-tRNA ligase activity
INE72_RS05670	COG0561	phosphatase activity
INE72_RS05680	COG0482	sulfurtransferase activity
INE72_RS05690	COG0205	6-phosphofructokinase activity
INE72_RS05695	COG0571	ribonuclease III activity
INE72_RS05700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE72_RS05705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE72_RS05725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE72_RS05740	COG0562	UDP-galactopyranose mutase
INE72_RS05745	COG0438	transferase activity, transferring glycosyl groups
INE72_RS05760	COG0438	transferase activity, transferring glycosyl groups
INE72_RS05765	COG3475	LICD family
INE72_RS05770	COG4750	Nucleotidyl transferase
INE72_RS05785	COG0463	Glycosyl transferase, family 2
INE72_RS05790	COG1216	Glycosyl transferase, family 2
INE72_RS05800	COG1215	transferase activity, transferring glycosyl groups
INE72_RS05805	COG1216	Glycosyl transferase, family 2
INE72_RS05810	COG1216	Glycosyl transferase, family 2
INE72_RS05810	COG1442	glycosyl transferase family 8
INE72_RS05815	COG1216	Glycosyl transferase, family 2
INE72_RS05870	COG1132	(ABC) transporter
INE72_RS05875	COG3119	arylsulfatase activity
INE72_RS05885	COG0463	Glycosyl transferase, family 2
INE72_RS05895	COG3341	Caulimovirus viroplasmin
INE72_RS05895	COG0328	RNA-DNA hybrid ribonuclease activity
INE72_RS05905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE72_RS05915	COG0326	Molecular chaperone. Has ATPase activity
INE72_RS05925	COG1166	arginine decarboxylase activity
INE72_RS05930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE72_RS05955	COG0779	Required for maturation of 30S ribosomal subunits
INE72_RS05960	COG0195	Participates in both transcription termination and antitermination
INE72_RS05965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE72_RS05975	COG0719	Fe-S assembly protein
INE72_RS05980	COG0396	ATPase activity
INE72_RS05985	COG0719	Fe-S assembly protein
INE72_RS05990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE72_RS05995	COG0393	Putative heavy-metal-binding
INE72_RS06000	COG3119	arylsulfatase activity
INE72_RS06010	COG4206	TonB-dependent receptor
INE72_RS06010	COG1629	transport
INE72_RS06020	COG1595	DNA-templated transcription, initiation
INE72_RS06040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE72_RS06045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE72_RS06055	COG2205	protein histidine kinase activity
INE72_RS06055	COG0745	RESPONSE REGULATOR receiver
INE72_RS06055	COG3292	Two component regulator propeller
INE72_RS06060	COG4771	TonB-dependent receptor
INE72_RS06080	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS06085	COG3537	Alpha-1,2-mannosidase
INE72_RS06105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE72_RS06120	COG0187	DNA topoisomerase II activity
INE72_RS06125	COG0268	Binds directly to 16S ribosomal RNA
INE72_RS06150	COG1381	Involved in DNA repair and RecF pathway recombination
INE72_RS06205	COG4974	Belongs to the 'phage' integrase family
INE72_RS06230	COG1040	competence protein
INE72_RS06270	COG0784	Response regulator, receiver
INE72_RS06270	COG2205	protein histidine kinase activity
INE72_RS06275	COG1082	Xylose isomerase domain protein TIM barrel
INE72_RS06280	COG1501	Belongs to the glycosyl hydrolase 31 family
INE72_RS06300	COG4771	TonB-dependent receptor
INE72_RS06325	COG1475	DNA binding
INE72_RS06475	COG0433	COG0433 Predicted ATPase
INE72_RS06505	COG0582	viral genome integration into host DNA
INE72_RS06540	COG1610	YqeY-like protein
INE72_RS06545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE72_RS06560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE72_RS06565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE72_RS06570	COG0772	Belongs to the SEDS family
INE72_RS06575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE72_RS06580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE72_RS06585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE72_RS06600	COG0275	rRNA processing
INE72_RS06605	COG2001	Belongs to the MraZ family
INE72_RS06610	COG1595	DNA-templated transcription, initiation
INE72_RS06625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
INE72_RS06630	COG0756	dUTP diphosphatase activity
INE72_RS06645	COG4942	peptidase
INE72_RS06650	COG2017	converts alpha-aldose to the beta-anomer
INE72_RS06655	COG2818	Glycosylase
INE72_RS06710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE72_RS06750	COG1595	DNA-templated transcription, initiation
INE72_RS06755	COG1022	Amp-dependent synthetase and ligase
INE72_RS06770	COG2954	triphosphatase activity
INE72_RS06835	COG0561	phosphatase activity
INE72_RS06875	COG0423	glycine-tRNA ligase activity
INE72_RS06885	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE72_RS06900	COG2211	Major facilitator Superfamily
INE72_RS06910	COG1215	transferase activity, transferring glycosyl groups
INE72_RS06915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE72_RS06945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE72_RS06950	COG0589	response to stress
INE72_RS06950	COG0475	glutathione-regulated potassium exporter activity
INE72_RS06955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE72_RS06960	COG1136	(ABC) transporter
INE72_RS06970	COG0733	neurotransmitter:sodium symporter activity
INE72_RS06980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE72_RS06990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE72_RS06995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE72_RS07015	COG1082	Xylose isomerase domain protein TIM barrel
INE72_RS07020	COG3507	Belongs to the glycosyl hydrolase 43 family
INE72_RS07025	COG3292	Two component regulator propeller
INE72_RS07025	COG2205	protein histidine kinase activity
INE72_RS07025	COG0745	RESPONSE REGULATOR receiver
INE72_RS07030	COG4771	TonB-dependent receptor
INE72_RS07040	COG4206	TonB-dependent receptor
INE72_RS07040	COG1629	transport
INE72_RS07100	COG1346	cytolysis
INE72_RS07105	COG1380	Effector of murein hydrolase LrgA
INE72_RS07110	COG0280	phosphate acetyltransferase
INE72_RS07115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE72_RS07120	COG0463	Glycosyl transferase, family 2
INE72_RS07120	COG1216	Glycosyl transferase, family 2
INE72_RS07125	COG2003	Belongs to the UPF0758 family
INE72_RS07135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE72_RS07140	COG1785	Belongs to the alkaline phosphatase family
INE72_RS07145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INE72_RS07150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE72_RS07155	COG0515	serine threonine protein kinase
INE72_RS07155	COG2815	serine threonine protein kinase
INE72_RS07160	COG0564	pseudouridine synthase activity
INE72_RS07190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INE72_RS07195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE72_RS07200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE72_RS07210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE72_RS07225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INE72_RS07230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE72_RS07240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE72_RS07240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE72_RS07245	COG2890	protein-(glutamine-N5) methyltransferase activity
INE72_RS07255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE72_RS07265	COG0165	Argininosuccinate lyase
INE72_RS07280	COG5492	domain, Protein
INE72_RS07290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE72_RS07295	COG1396	sequence-specific DNA binding
INE72_RS07295	COG1917	Cupin 2, conserved barrel domain protein
INE72_RS07300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE72_RS07305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE72_RS07310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INE72_RS07315	COG0137	argininosuccinate synthase activity
INE72_RS07325	COG1438	arginine binding
INE72_RS07330	COG1070	Carbohydrate kinase
INE72_RS07335	COG4806	L-rhamnose isomerase
INE72_RS07345	COG0235	Class ii aldolase
INE72_RS07350	COG1454	alcohol dehydrogenase
INE72_RS07375	COG0564	pseudouridine synthase activity
INE72_RS07390	COG3119	arylsulfatase activity
INE72_RS07410	COG0612	Peptidase, M16
INE72_RS07415	COG0534	Mate efflux family protein
INE72_RS07420	COG0784	Response regulator, receiver
INE72_RS07420	COG2205	protein histidine kinase activity
INE72_RS07440	COG0488	(ABC) transporter
INE72_RS07445	COG3590	peptidase
INE72_RS07450	COG0138	bifunctional purine biosynthesis protein purh
INE72_RS07475	COG0772	Belongs to the SEDS family
INE72_RS07485	COG1774	PSP1 C-terminal conserved region
INE72_RS07490	COG0470	DNA polymerase III
INE72_RS07495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE72_RS07540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE72_RS07545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE72_RS07550	COG1160	GTP binding
INE72_RS07560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE72_RS07565	COG1127	ABC transporter
INE72_RS07570	COG0724	RNA recognition motif
INE72_RS07575	COG0544	peptidyl-prolyl cis-trans isomerase activity
INE72_RS07580	COG0740	serine-type endopeptidase activity
INE72_RS07585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE72_RS07590	COG0514	ATP-dependent DNA helicase (RecQ)
INE72_RS07595	COG0517	IMP dehydrogenase activity
INE72_RS07595	COG0516	GMP reductase activity
INE72_RS07600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE72_RS07610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE72_RS07625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE72_RS07665	COG3022	response to hydroperoxide
INE72_RS07670	COG0110	maltose O-acetyltransferase activity
INE72_RS07690	COG1187	pseudouridine synthase activity
INE72_RS07695	COG0017	Asparaginyl-tRNA synthetase
INE72_RS07705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE72_RS07710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE72_RS07715	COG0052	Belongs to the universal ribosomal protein uS2 family
INE72_RS07720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE72_RS07735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE72_RS07740	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE72_RS07745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INE72_RS07765	COG0482	sulfurtransferase activity
INE72_RS07775	COG1570	exodeoxyribonuclease VII activity
INE72_RS07785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE72_RS07795	COG0489	protein tyrosine kinase activity
INE72_RS07800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS07830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS07850	COG0039	L-malate dehydrogenase activity
INE72_RS07860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE72_RS07865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
INE72_RS07870	COG0811	peptide transport
INE72_RS07890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INE72_RS07895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE72_RS07900	COG0105	UTP biosynthetic process
INE72_RS07905	COG0739	heme binding
INE72_RS07920	COG0149	triose-phosphate isomerase activity
INE72_RS07930	COG0302	gtp cyclohydrolase
INE72_RS07935	COG0358	DNA primase activity
INE72_RS07945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE72_RS07950	COG0436	Aminotransferase
INE72_RS07965	COG0514	ATP-dependent DNA helicase (RecQ)
INE72_RS07970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE72_RS07970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE72_RS07980	COG0009	L-threonylcarbamoyladenylate synthase
INE72_RS07990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE72_RS07995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE72_RS08000	COG0658	competence protein
INE72_RS08000	COG2333	competence protein COMEC
INE72_RS08005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE72_RS08015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE72_RS08020	COG4771	TonB-dependent receptor
INE72_RS08035	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE72_RS08040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE72_RS08050	COG0527	aspartate kinase activity
INE72_RS08050	COG0460	homoserine dehydrogenase
INE72_RS08055	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE72_RS08095	COG1522	sequence-specific DNA binding
INE72_RS08110	COG0251	oxidation-reduction process
INE72_RS08120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INE72_RS08125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE72_RS08125	COG1333	cytochrome c biogenesis protein
INE72_RS08135	COG0110	maltose O-acetyltransferase activity
INE72_RS08140	COG0386	Belongs to the glutathione peroxidase family
INE72_RS08145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE72_RS08150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE72_RS08165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE72_RS08180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE72_RS08185	COG0742	ribosomal rna small subunit methyltransferase
INE72_RS08200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE72_RS08210	COG4771	TonB-dependent receptor
INE72_RS08220	COG3537	Alpha-1,2-mannosidase
INE72_RS08225	COG3537	Alpha-1,2-mannosidase
INE72_RS08245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE72_RS08250	COG0739	heme binding
INE72_RS08260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE72_RS08265	COG0741	lytic transglycosylase activity
INE72_RS08265	COG1388	LysM domain
INE72_RS08275	COG1475	DNA binding
INE72_RS08280	COG1192	Involved in chromosome partitioning
INE72_RS08285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE72_RS08290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE72_RS08305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE72_RS08320	COG1196	nuclear chromosome segregation
INE72_RS08325	COG2239	Acts as a magnesium transporter
INE72_RS08330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE72_RS08340	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE72_RS08360	COG3250	beta-galactosidase activity
INE72_RS08380	COG0668	transmembrane transport
INE72_RS08385	COG2207	Transcriptional regulator
INE72_RS08385	COG0662	Cupin 2, conserved barrel domain protein
INE72_RS08415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE72_RS08420	COG0713	ATP synthesis coupled electron transport
INE72_RS08435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE72_RS08440	COG0649	NAD binding
INE72_RS08440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE72_RS08445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE72_RS08450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE72_RS08460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE72_RS08465	COG0569	domain protein
INE72_RS08470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE72_RS08480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE72_RS08485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE72_RS08490	COG0805	protein transport
INE72_RS08500	COG2271	Major facilitator Superfamily
INE72_RS08505	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE72_RS08510	COG3775	system Galactitol-specific IIC component
INE72_RS08515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS08525	COG2755	lipolytic protein G-D-S-L family
INE72_RS08530	COG0745	RESPONSE REGULATOR receiver
INE72_RS08530	COG3292	Two component regulator propeller
INE72_RS08530	COG2205	protein histidine kinase activity
INE72_RS08540	COG0702	epimerase
INE72_RS08545	COG4771	TonB-dependent receptor
INE72_RS08565	COG3279	Response regulator of the LytR AlgR family
INE72_RS08570	COG1242	4 iron, 4 sulfur cluster binding
INE72_RS08580	COG0363	glucosamine-6-phosphate deaminase activity
INE72_RS08585	COG0009	L-threonylcarbamoyladenylate synthase
INE72_RS08595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE72_RS08600	COG0561	phosphatase activity
INE72_RS08620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE72_RS08635	COG1629	transport
INE72_RS08635	COG4206	TonB-dependent receptor
INE72_RS08655	COG1501	Belongs to the glycosyl hydrolase 31 family
INE72_RS08660	COG3507	Belongs to the glycosyl hydrolase 43 family
INE72_RS08675	COG3250	beta-galactosidase activity
INE72_RS08710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE72_RS08720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE72_RS08730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE72_RS08770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE72_RS08785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE72_RS08785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE72_RS08790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE72_RS08795	COG1078	dGTPase activity
INE72_RS08800	COG0284	orotidine-5'-phosphate decarboxylase activity
INE72_RS08805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE72_RS08815	COG1704	LemA family
INE72_RS08830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE72_RS08835	COG2226	methyltransferase
INE72_RS08840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE72_RS08845	COG1702	phosphate starvation-inducible protein PhoH
INE72_RS08865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
INE72_RS08965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS09040	COG4974	Belongs to the 'phage' integrase family
INE72_RS09090	COG4974	Belongs to the 'phage' integrase family
INE72_RS09095	COG4974	Belongs to the 'phage' integrase family
INE72_RS09185	COG1475	DNA binding
INE72_RS09195	COG1192	Involved in chromosome partitioning
INE72_RS09230	COG1196	nuclear chromosome segregation
INE72_RS09230	COG0741	lytic transglycosylase activity
INE72_RS09230	COG0739	heme binding
INE72_RS09290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE72_RS09335	COG4886	Leucine-rich repeat (LRR) protein
INE72_RS09335	COG4932	domain protein
INE72_RS09365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE72_RS09370	COG1120	ATPase activity
INE72_RS09525	COG3292	Two component regulator propeller
INE72_RS09525	COG2205	protein histidine kinase activity
INE72_RS09525	COG0745	RESPONSE REGULATOR receiver
INE72_RS09530	COG0101	tRNA pseudouridine synthase activity
INE72_RS09550	COG3250	beta-galactosidase activity
INE72_RS09555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE72_RS09560	COG0673	inositol 2-dehydrogenase activity
INE72_RS09585	COG1629	transport
INE72_RS09600	COG4771	TonB-dependent receptor
INE72_RS09605	COG0702	epimerase
INE72_RS09625	COG5434	Belongs to the glycosyl hydrolase 28 family
INE72_RS09635	COG1629	transport
INE72_RS09640	COG0561	phosphatase activity
INE72_RS09660	COG0673	inositol 2-dehydrogenase activity
INE72_RS09675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INE72_RS09685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INE72_RS09700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE72_RS09705	COG0793	Belongs to the peptidase S41A family
INE72_RS09710	COG2131	deaminase
INE72_RS09720	COG0339	signal peptide processing
INE72_RS09730	COG1970	mechanosensitive ion channel activity
INE72_RS09750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE72_RS09750	COG0519	Catalyzes the synthesis of GMP from XMP
INE72_RS09900	COG0622	Phosphoesterase
INE72_RS09925	COG4771	TonB-dependent receptor
INE72_RS09945	COG1132	(ABC) transporter
INE72_RS09950	COG2375	cellular response to nickel ion
INE72_RS09950	COG1132	(ABC) transporter
INE72_RS09960	COG0428	transporter
INE72_RS10005	COG3015	lipoprotein NlpE involved in copper resistance
INE72_RS10140	COG0745	RESPONSE REGULATOR receiver
INE72_RS10140	COG2205	protein histidine kinase activity
INE72_RS10140	COG0745	RESPONSE REGULATOR receiver
INE72_RS10140	COG3292	Two component regulator propeller
INE72_RS10140	COG2205	protein histidine kinase activity
INE72_RS10140	COG3292	Two component regulator propeller
INE72_RS10185	COG0702	epimerase
INE72_RS10190	COG1629	transport
INE72_RS10195	COG3292	Two component regulator propeller
INE72_RS10195	COG2205	protein histidine kinase activity
INE72_RS10195	COG0745	RESPONSE REGULATOR receiver
INE72_RS10230	COG2095	MarC family integral membrane protein
INE72_RS10240	COG1830	Aldolase
INE72_RS10245	COG0588	phosphoglycerate mutase activity
INE72_RS10260	COG0205	6-phosphofructokinase activity
INE72_RS10265	COG4651	solute:proton antiporter activity
INE72_RS10265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE72_RS10270	COG0058	SHG alpha-glucan phosphorylase activity
INE72_RS10275	COG0010	Belongs to the arginase family
INE72_RS10285	COG2205	protein histidine kinase activity
INE72_RS10285	COG2198	Histidine kinase
INE72_RS10285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE72_RS10285	COG0784	Response regulator, receiver
INE72_RS10350	COG0739	heme binding
INE72_RS10425	COG4974	Belongs to the 'phage' integrase family
INE72_RS10440	COG4771	TonB-dependent receptor
INE72_RS10445	COG0561	phosphatase activity
INE72_RS10450	COG1629	transport
INE72_RS10480	COG0438	transferase activity, transferring glycosyl groups
INE72_RS10495	COG0297	glycogen (starch) synthase activity
INE72_RS10500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE72_RS10505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE72_RS10510	COG0543	2 iron, 2 sulfur cluster binding
INE72_RS10520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE72_RS10525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE72_RS10530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE72_RS10545	COG0791	NLP P60 protein
INE72_RS10560	COG0612	Peptidase, M16
INE72_RS10565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE72_RS10570	COG1597	lipid kinase activity
INE72_RS10575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE72_RS10585	COG0702	epimerase
INE72_RS10590	COG4771	TonB-dependent receptor
INE72_RS10605	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS10610	COG0745	RESPONSE REGULATOR receiver
INE72_RS10610	COG3292	Two component regulator propeller
INE72_RS10610	COG2205	protein histidine kinase activity
INE72_RS10625	COG1136	(ABC) transporter
INE72_RS10645	COG2211	Major facilitator Superfamily
INE72_RS10650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE72_RS10665	COG1674	ftsk spoiiie
INE72_RS10675	COG0492	ferredoxin-NADP+ reductase activity
INE72_RS10680	COG3118	belongs to the thioredoxin family
INE72_RS10690	COG1404	Belongs to the peptidase S8 family
INE72_RS10710	COG1629	transport
INE72_RS10710	COG4206	TonB-dependent receptor
INE72_RS10745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE72_RS10745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE72_RS10750	COG0539	negative regulation of cytoplasmic translation
INE72_RS10755	COG1234	tRNA 3'-trailer cleavage
INE72_RS10760	COG2989	Protein conserved in bacteria
INE72_RS10780	COG3956	TIGRFAM MazG family protein
INE72_RS10795	COG0525	valine-tRNA ligase activity
INE72_RS10800	COG0784	Response regulator, receiver
INE72_RS10800	COG2205	protein histidine kinase activity
INE72_RS10815	COG1629	transport
INE72_RS10855	COG4771	TonB-dependent receptor
INE72_RS10860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE72_RS10865	COG3292	Two component regulator propeller
INE72_RS10865	COG2205	protein histidine kinase activity
INE72_RS10865	COG0745	RESPONSE REGULATOR receiver
INE72_RS10880	COG0653	protein targeting
INE72_RS10885	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE72_RS10895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
INE72_RS10915	COG1253	flavin adenine dinucleotide binding
INE72_RS10920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE72_RS10925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE72_RS10935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE72_RS10980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INE72_RS10980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE72_RS10990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE72_RS10995	COG0563	adenylate kinase activity
INE72_RS11000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE72_RS11005	COG1496	oxidoreductase activity
INE72_RS11025	COG1629	transport
INE72_RS11025	COG4206	TonB-dependent receptor
INE72_RS11030	COG0561	phosphatase activity
INE72_RS11035	COG3119	arylsulfatase activity
INE72_RS11050	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS11065	COG2814	Major facilitator Superfamily
INE72_RS11070	COG0457	Tetratricopeptide repeat
INE72_RS11075	COG2706	6-phosphogluconolactonase activity
INE72_RS11085	COG4771	TonB-dependent receptor
INE72_RS11090	COG0702	epimerase
INE72_RS11095	COG1472	Belongs to the glycosyl hydrolase 3 family
INE72_RS11135	COG0358	DNA primase activity
INE72_RS11165	COG3292	Two component regulator propeller
INE72_RS11165	COG2205	protein histidine kinase activity
INE72_RS11165	COG3292	Two component regulator propeller
INE72_RS11165	COG0745	RESPONSE REGULATOR receiver
INE72_RS11165	COG0745	RESPONSE REGULATOR receiver
INE72_RS11165	COG2205	protein histidine kinase activity
INE72_RS11170	COG1629	transport
INE72_RS11270	COG3142	Participates in the control of copper homeostasis
INE72_RS11275	COG1418	mRNA catabolic process
INE72_RS11290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE72_RS11295	COG2832	Protein of unknown function (DUF454)
INE72_RS11305	COG0602	queuosine metabolic process
INE72_RS11310	COG0247	lactate metabolic process
INE72_RS11315	COG1139	Iron-sulfur cluster binding protein
INE72_RS11325	COG0351	phosphomethylpyrimidine kinase
INE72_RS11330	COG4771	TonB-dependent receptor
INE72_RS11340	COG2304	oxidoreductase activity
INE72_RS11350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS11360	COG1393	Belongs to the ArsC family
INE72_RS11370	COG4771	TonB-dependent receptor
INE72_RS11385	COG2233	PERMEase
INE72_RS11390	COG1509	lysine 2,3-aminomutase activity
INE72_RS11425	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS11435	COG0776	regulation of translation
INE72_RS11440	COG0305	Participates in initiation and elongation during chromosome replication
INE72_RS11470	COG3250	beta-galactosidase activity
INE72_RS11475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INE72_RS11485	COG1388	LysM domain
INE72_RS11485	COG0741	lytic transglycosylase activity
INE72_RS11530	COG0534	Mate efflux family protein
INE72_RS11540	COG0564	pseudouridine synthase activity
INE72_RS11570	COG0346	lactoylglutathione lyase activity
INE72_RS11585	COG1401	restriction endodeoxyribonuclease activity
INE72_RS11590	COG4268	DNA restriction-modification system
INE72_RS11610	COG0432	Pfam Uncharacterised protein family UPF0047
INE72_RS11615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE72_RS11625	COG2910	NAD(P)H-binding
INE72_RS11635	COG4864	UPF0365 protein
INE72_RS11650	COG0037	tRNA processing
INE72_RS11660	COG1477	protein flavinylation
INE72_RS11665	COG1971	Probably functions as a manganese efflux pump
INE72_RS11680	COG0463	Glycosyl transferase, family 2
INE72_RS11705	COG1595	DNA-templated transcription, initiation
INE72_RS11710	COG0148	phosphopyruvate hydratase activity
INE72_RS11720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE72_RS11725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE72_RS11730	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE72_RS11735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE72_RS11740	COG4651	solute:proton antiporter activity
INE72_RS11740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE72_RS11750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE72_RS11755	COG0193	aminoacyl-tRNA hydrolase activity
INE72_RS11760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE72_RS11770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE72_RS11775	COG1862	Preprotein translocase
INE72_RS11785	COG0237	dephospho-CoA kinase activity
INE72_RS11795	COG0542	response to heat
INE72_RS11805	COG0583	DNA-binding transcription factor activity
INE72_RS11830	COG3177	Filamentation induced by cAMP protein fic
INE72_RS11835	COG3304	Inner membrane component domain
INE72_RS11840	COG2855	membrane
INE72_RS11845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INE72_RS11850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE72_RS11880	COG0443	Heat shock 70 kDa protein
INE72_RS11885	COG0306	phosphate transporter
INE72_RS11895	COG0586	Pfam SNARE associated Golgi protein
INE72_RS11930	COG0038	chloride channel
INE72_RS11935	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE72_RS11940	COG2172	sigma factor antagonist activity
INE72_RS11965	COG1366	Belongs to the anti-sigma-factor antagonist family
INE72_RS11970	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE72_RS11975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE72_RS11990	COG3250	beta-galactosidase activity
INE72_RS12005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE72_RS12010	COG1629	transport
INE72_RS12010	COG4206	TonB-dependent receptor
INE72_RS12020	COG0745	RESPONSE REGULATOR receiver
INE72_RS12020	COG2205	protein histidine kinase activity
INE72_RS12020	COG3292	Two component regulator propeller
INE72_RS12040	COG1760	l-serine dehydratase
INE72_RS12045	COG0598	Magnesium transport protein CorA
INE72_RS12050	COG1193	negative regulation of DNA recombination
INE72_RS12060	COG4974	Belongs to the 'phage' integrase family
INE72_RS12180	COG0551	DNA topoisomerase type I activity
INE72_RS12180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS12205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE72_RS12230	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
INE72_RS12245	COG3189	MarR family transcriptional regulator
INE72_RS12250	COG0561	phosphatase activity
INE72_RS12255	COG1169	isochorismate synthase
INE72_RS12260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE72_RS12265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INE72_RS12270	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS12280	COG0783	Belongs to the Dps family
INE72_RS12285	COG0583	DNA-binding transcription factor activity
INE72_RS12310	COG2433	Pfam Transposase IS66
INE72_RS12365	COG1333	cytochrome c biogenesis protein
INE72_RS12365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE72_RS12460	COG4974	Belongs to the 'phage' integrase family
INE72_RS12465	COG4974	Belongs to the 'phage' integrase family
INE72_RS12470	COG4974	Belongs to the 'phage' integrase family
INE72_RS12500	COG2204	response regulator
INE72_RS12595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS12595	COG0551	DNA topoisomerase type I activity
INE72_RS12665	COG1192	Involved in chromosome partitioning
INE72_RS12745	COG0358	DNA primase activity
INE72_RS12760	COG4974	Belongs to the 'phage' integrase family
INE72_RS12765	COG4974	Belongs to the 'phage' integrase family
INE72_RS12770	COG4974	Belongs to the 'phage' integrase family
INE72_RS12805	COG0484	heat shock protein binding
INE72_RS12865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INE72_RS12885	COG3458	cephalosporin-C deacetylase activity
INE72_RS12890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE72_RS12895	COG1882	Formate acetyltransferase
INE72_RS12935	COG4804	nuclease activity
INE72_RS12980	COG1253	flavin adenine dinucleotide binding
INE72_RS12985	COG0501	Belongs to the peptidase M48B family
INE72_RS13010	COG0482	sulfurtransferase activity
INE72_RS13015	COG2197	response regulator
INE72_RS13025	COG1757	Na H antiporter
INE72_RS13035	COG2814	Major facilitator Superfamily
INE72_RS13040	COG4953	penicillin-binding protein 1C
INE72_RS13045	COG2373	Large extracellular alpha-helical protein
INE72_RS13050	COG0545	Peptidyl-prolyl cis-trans isomerase
INE72_RS13095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE72_RS13100	COG0646	methionine synthase
INE72_RS13100	COG1410	methionine synthase
INE72_RS13105	COG0778	Nitroreductase
INE72_RS13115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE72_RS13120	COG0572	uridine kinase
INE72_RS13130	COG4232	protein-disulfide reductase activity
INE72_RS13135	COG0738	Major facilitator superfamily
INE72_RS13145	COG1070	Carbohydrate kinase
INE72_RS13155	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
INE72_RS13160	COG2188	Transcriptional regulator
INE72_RS13165	COG0228	four-way junction DNA binding
INE72_RS13190	COG3275	phosphorelay sensor kinase activity
INE72_RS13200	COG2205	protein histidine kinase activity
INE72_RS13200	COG0784	Response regulator, receiver
INE72_RS13215	COG1733	regulation of RNA biosynthetic process
INE72_RS13240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE72_RS13245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE72_RS13250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE72_RS13255	COG0131	Imidazoleglycerol-phosphate dehydratase
INE72_RS13275	COG1592	Rubrerythrin
INE72_RS13275	COG1773	rubredoxin
INE72_RS13290	COG0702	epimerase
INE72_RS13295	COG4771	TonB-dependent receptor
INE72_RS13320	COG3118	belongs to the thioredoxin family
INE72_RS13335	COG3591	Belongs to the peptidase S1B family
INE72_RS13340	COG3591	Belongs to the peptidase S1B family
INE72_RS13345	COG0641	radical SAM
INE72_RS13360	COG0420	3'-5' exonuclease activity
INE72_RS13370	COG1408	metallophosphoesterase
INE72_RS13385	COG0646	methionine synthase
INE72_RS13385	COG1410	methionine synthase
INE72_RS13395	COG0463	Glycosyl transferase, family 2
INE72_RS13400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE72_RS13405	COG1032	radical SAM domain protein
INE72_RS13425	COG0363	glucosamine-6-phosphate deaminase activity
INE72_RS13430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE72_RS13450	COG4974	Belongs to the 'phage' integrase family
INE72_RS13490	COG0551	DNA topoisomerase type I activity
INE72_RS13490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS13505	COG0582	viral genome integration into host DNA
INE72_RS13530	COG0784	Response regulator, receiver
INE72_RS13530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE72_RS13530	COG2198	Histidine kinase
INE72_RS13530	COG2205	protein histidine kinase activity
INE72_RS13660	COG0358	DNA primase activity
INE72_RS13675	COG4974	Belongs to the 'phage' integrase family
INE72_RS13680	COG4974	Belongs to the 'phage' integrase family
INE72_RS13685	COG4974	Belongs to the 'phage' integrase family
INE72_RS13770	COG1131	(ABC) transporter
INE72_RS13805	COG1752	Esterase of the alpha-beta hydrolase superfamily
INE72_RS13830	COG3757	hydrolase, family 25
INE72_RS13845	COG0508	dehydrogenase complex catalyzes the overall conversion of
INE72_RS13850	COG0022	dehydrogenase e1 component
INE72_RS13860	COG2264	protein methyltransferase activity
INE72_RS13880	COG0590	tRNA wobble adenosine to inosine editing
INE72_RS13885	COG0673	inositol 2-dehydrogenase activity
INE72_RS13890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE72_RS13935	COG0698	ribose 5-phosphate isomerase
INE72_RS13955	COG2160	L-arabinose isomerase activity
INE72_RS13985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE72_RS14000	COG1482	cell wall glycoprotein biosynthetic process
INE72_RS14020	COG4221	oxidoreductase activity
INE72_RS14030	COG1218	3'(2'),5'-bisphosphate nucleotidase
INE72_RS14035	COG3273	potassium ion transport
INE72_RS14035	COG0471	metal ion transport
INE72_RS14040	COG0529	Catalyzes the synthesis of activated sulfate
INE72_RS14045	COG0175	sulfate reduction
INE72_RS14050	COG2895	sulfate adenylyltransferase (ATP) activity
INE72_RS14070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE72_RS14075	COG0242	peptide deformylase activity
INE72_RS14085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE72_RS14090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE72_RS14095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE72_RS14100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE72_RS14110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE72_RS14115	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE72_RS14120	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE72_RS14120	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE72_RS14120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE72_RS14120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
INE72_RS14130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE72_RS14145	COG1940	carbohydrate kinase activity
INE72_RS14150	COG2731	YhcH YjgK YiaL family protein
INE72_RS14155	COG2271	Major facilitator Superfamily
INE72_RS14160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE72_RS14170	COG4771	TonB-dependent receptor
INE72_RS14175	COG0702	epimerase
INE72_RS14185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS14205	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS14210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS14215	COG4771	TonB-dependent receptor
INE72_RS14220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE72_RS14225	COG0484	heat shock protein binding
INE72_RS14230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE72_RS14235	COG0488	(ABC) transporter
INE72_RS14250	COG2183	response to ionizing radiation
INE72_RS14255	COG2202	Pas domain
INE72_RS14255	COG2205	protein histidine kinase activity
INE72_RS14260	COG0737	Belongs to the 5'-nucleotidase family
INE72_RS14305	COG2985	domain, Protein
INE72_RS14305	COG0490	domain, Protein
INE72_RS14310	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE72_RS14320	COG0318	PFAM AMP-dependent synthetase and ligase
INE72_RS14325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE72_RS14330	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE72_RS14335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
INE72_RS14340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE72_RS14345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE72_RS14350	COG0363	glucosamine-6-phosphate deaminase activity
INE72_RS14365	COG3279	Response regulator of the LytR AlgR family
INE72_RS14375	COG1136	(ABC) transporter
INE72_RS14375	COG0577	efflux transmembrane transporter activity
INE72_RS14380	COG1136	(ABC) transporter
INE72_RS14385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS14410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE72_RS14415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE72_RS14445	COG1704	LemA family
INE72_RS14455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE72_RS14460	COG2885	chlorophyll binding
INE72_RS14465	COG0534	Mate efflux family protein
INE72_RS14470	COG2755	lipolytic protein G-D-S-L family
INE72_RS14470	COG0657	acetylesterase activity
INE72_RS14475	COG0784	Response regulator, receiver
INE72_RS14475	COG2205	protein histidine kinase activity
INE72_RS14490	COG0488	(ABC) transporter
INE72_RS14505	COG0784	Response regulator, receiver
INE72_RS14505	COG2205	protein histidine kinase activity
INE72_RS14535	COG2244	polysaccharide biosynthetic process
INE72_RS14540	COG0438	transferase activity, transferring glycosyl groups
INE72_RS14560	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS14605	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE72_RS14610	COG1805	sodium ion transport
INE72_RS14615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE72_RS14630	COG2871	sodium ion transport
INE72_RS14640	COG0513	Belongs to the DEAD box helicase family
INE72_RS14645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE72_RS14650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE72_RS14660	COG1739	Uncharacterized protein family UPF0029
INE72_RS14675	COG0778	Nitroreductase
INE72_RS14680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE72_RS14680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE72_RS14685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE72_RS14690	COG0357	Ribosomal RNA small subunit methyltransferase G
INE72_RS14705	COG1629	transport
INE72_RS14705	COG4206	TonB-dependent receptor
INE72_RS14715	COG2217	Heavy metal translocating P-type atpase
INE72_RS14725	COG0321	lipoyl(octanoyl) transferase activity
INE72_RS14755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
INE72_RS14765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE72_RS14780	COG1678	Uncharacterized ACR, COG1678
INE72_RS14795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE72_RS14800	COG0662	Cupin 2, conserved barrel domain protein
INE72_RS14800	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE72_RS14820	COG1131	(ABC) transporter
INE72_RS14825	COG0842	Transport permease protein
INE72_RS14830	COG0842	Transport permease protein
INE72_RS14835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE72_RS14840	COG2949	membrane
INE72_RS14850	COG0556	nucleotide-excision repair
INE72_RS14855	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE72_RS14885	COG1388	LysM domain
INE72_RS14885	COG3942	CHAP domain
INE72_RS14895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE72_RS14910	COG1695	Transcriptional regulator
INE72_RS14930	COG0823	Involved in the tonB-independent uptake of proteins
INE72_RS14930	COG1506	peptidase
INE72_RS14935	COG0534	Mate efflux family protein
INE72_RS14940	COG0706	membrane insertase activity
INE72_RS14945	COG0504	CTP synthase activity
INE72_RS15005	COG1083	cytidylyl-transferase
INE72_RS15010	COG2089	acid synthase
INE72_RS15015	COG2244	polysaccharide biosynthetic process
INE72_RS15040	COG1216	Glycosyl transferase, family 2
INE72_RS15055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE72_RS15105	COG4656	Part of a membrane complex involved in electron transport
INE72_RS15110	COG4658	electron transport chain
INE72_RS15115	COG4659	FMN binding
INE72_RS15120	COG4660	Part of a membrane complex involved in electron transport
INE72_RS15125	COG4657	Part of a membrane complex involved in electron transport
INE72_RS15130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE72_RS15135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INE72_RS15140	COG0305	Participates in initiation and elongation during chromosome replication
INE72_RS15145	COG0072	phenylalanine-tRNA ligase activity
INE72_RS15145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE72_RS15150	COG0217	transcriptional regulatory protein
INE72_RS15165	COG0708	Exodeoxyribonuclease III
INE72_RS15180	COG0481	GTPase activity
INE72_RS15205	COG0024	Methionine aminopeptidase
INE72_RS15225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE72_RS15230	COG0574	Belongs to the PEP-utilizing enzyme family
INE72_RS15230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE72_RS15255	COG1192	Involved in chromosome partitioning
INE72_RS15370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE72_RS15425	COG1192	Involved in chromosome partitioning
INE72_RS15440	COG0556	nucleotide-excision repair
INE72_RS15465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE72_RS15540	COG0358	DNA primase activity
INE72_RS15580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
INE72_RS15590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE72_RS15595	COG2022	thiamine diphosphate biosynthetic process
INE72_RS15600	COG0352	thiamine-phosphate diphosphorylase activity
INE72_RS15610	COG3850	Histidine kinase
INE72_RS15610	COG4999	Histidine kinase
INE72_RS15610	COG2205	protein histidine kinase activity
INE72_RS15610	COG3437	response regulator, receiver
INE72_RS15625	COG0210	DNA helicase
INE72_RS15705	COG0681	Belongs to the peptidase S26 family
INE72_RS15720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS15790	COG1082	Xylose isomerase domain protein TIM barrel
INE72_RS15795	COG1022	Amp-dependent synthetase and ligase
INE72_RS15800	COG3263	regulation of cellular component size
INE72_RS15805	COG2233	PERMEase
INE72_RS15810	COG1151	hydroxylamine reductase activity
INE72_RS15830	COG0561	phosphatase activity
INE72_RS15850	COG0577	efflux transmembrane transporter activity
INE72_RS15850	COG1136	(ABC) transporter
INE72_RS15860	COG0534	Mate efflux family protein
INE72_RS15865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE72_RS15870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE72_RS15880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE72_RS15900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE72_RS15905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INE72_RS15910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INE72_RS15920	COG0356	it plays a direct role in the translocation of protons across the membrane
INE72_RS15925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE72_RS15930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE72_RS15935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE72_RS15940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE72_RS15945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE72_RS15950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE72_RS15955	COG2431	L-lysine efflux transmembrane transporter activity
INE72_RS15975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INE72_RS15975	COG2207	Transcriptional regulator
INE72_RS16000	COG2985	domain, Protein
INE72_RS16005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE72_RS16010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE72_RS16025	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE72_RS16030	COG0540	Belongs to the ATCase OTCase family
INE72_RS16105	COG0582	viral genome integration into host DNA
INE72_RS16120	COG1475	DNA binding
INE72_RS16210	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE72_RS16215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE72_RS16285	COG0739	heme binding
INE72_RS16345	COG3617	BRO family, N-terminal domain
INE72_RS16485	COG1215	transferase activity, transferring glycosyl groups
INE72_RS16490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE72_RS16500	COG0438	transferase activity, transferring glycosyl groups
INE72_RS16545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE72_RS16610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE72_RS16620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE72_RS16635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE72_RS16640	COG2205	protein histidine kinase activity
INE72_RS16740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
INE72_RS16915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE72_RS16930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE72_RS16950	COG0348	domain, Protein
INE72_RS16955	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE72_RS16970	COG2326	polyphosphate kinase activity
INE72_RS16995	COG0724	RNA recognition motif
INE72_RS17000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
INE72_RS17005	COG0045	succinate-CoA ligase (ADP-forming) activity
INE72_RS17010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE72_RS17015	COG0351	phosphomethylpyrimidine kinase
INE72_RS17030	COG2115	Belongs to the xylose isomerase family
INE72_RS17035	COG0477	Major facilitator Superfamily
INE72_RS17035	COG2814	Major facilitator Superfamily
INE72_RS17040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE72_RS17040	COG3153	acetyltransferase
INE72_RS17050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE72_RS17060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE72_RS17075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE72_RS17100	COG3015	lipoprotein NlpE involved in copper resistance
INE72_RS17120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE72_RS17135	COG1904	glucuronate isomerase
INE72_RS17145	COG0246	Mannitol dehydrogenase
INE72_RS17175	COG0513	Belongs to the DEAD box helicase family
INE72_RS17180	COG0560	Phosphoserine phosphatase
INE72_RS17180	COG3830	Belongs to the UPF0237 family
INE72_RS17200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE72_RS17205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE72_RS17235	COG0592	DNA-directed DNA polymerase activity
INE72_RS17260	COG0305	Participates in initiation and elongation during chromosome replication
INE72_RS17450	COG0863	Belongs to the N(4) N(6)-methyltransferase family
INE72_RS17455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE72_RS17595	COG0577	efflux transmembrane transporter activity
INE72_RS17595	COG1136	(ABC) transporter
INE72_RS17625	COG0156	8-amino-7-oxononanoate synthase activity
INE72_RS17630	COG1597	lipid kinase activity
INE72_RS17635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE72_RS17650	COG2957	Belongs to the agmatine deiminase family
INE72_RS17685	COG0702	epimerase
INE72_RS17705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE72_RS17715	COG1538	Outer membrane efflux protein
INE72_RS17735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE72_RS17750	COG0543	2 iron, 2 sulfur cluster binding
INE72_RS17755	COG0167	dihydroorotate dehydrogenase activity
INE72_RS17760	COG0336	Belongs to the RNA methyltransferase TrmD family
INE72_RS17765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE72_RS17770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE72_RS17790	COG1752	Esterase of the alpha-beta hydrolase superfamily
INE72_RS17795	COG0326	Molecular chaperone. Has ATPase activity
INE72_RS17800	COG0542	response to heat
INE72_RS17805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INE72_RS17845	COG2304	oxidoreductase activity
INE72_RS17860	COG0714	Associated with various cellular activities
INE72_RS17870	COG0776	regulation of translation
INE72_RS17875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE72_RS17880	COG0552	protein localization to endoplasmic reticulum
INE72_RS17890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE72_RS17895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE72_RS17905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE72_RS17940	COG5002	protein histidine kinase activity
INE72_RS17945	COG0745	RESPONSE REGULATOR receiver
INE72_RS17950	COG0442	prolyl-tRNA aminoacylation
INE72_RS17965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS17980	COG0745	RESPONSE REGULATOR receiver
INE72_RS17980	COG2205	protein histidine kinase activity
INE72_RS17980	COG3292	Two component regulator propeller
INE72_RS17990	COG4206	TonB-dependent receptor
INE72_RS18010	COG0738	Major facilitator superfamily
INE72_RS18030	COG1011	Hydrolase
INE72_RS18035	COG0300	oxidoreductase activity
INE72_RS18050	COG2966	Psort location CytoplasmicMembrane, score
INE72_RS18075	COG2205	protein histidine kinase activity
INE72_RS18075	COG0784	Response regulator, receiver
INE72_RS18120	COG1028	Short-chain dehydrogenase reductase Sdr
INE72_RS18130	COG3537	Alpha-1,2-mannosidase
INE72_RS18135	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE72_RS18145	COG1074	ATP-dependent DNA helicase activity
INE72_RS18175	COG1475	DNA binding
INE72_RS18180	COG3969	phosphoadenosine phosphosulfate
INE72_RS18200	COG0305	Participates in initiation and elongation during chromosome replication
INE72_RS18220	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS18260	COG1215	transferase activity, transferring glycosyl groups
INE72_RS18320	COG0505	Belongs to the CarA family
INE72_RS18335	COG0067	glutamate synthase
INE72_RS18335	COG0069	glutamate synthase activity
INE72_RS18335	COG0070	glutamate synthase
INE72_RS18345	COG0367	asparagine synthase
INE72_RS18365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
INE72_RS18370	COG0436	Aminotransferase
INE72_RS18390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE72_RS18405	COG0471	metal ion transport
INE72_RS18405	COG0490	domain, Protein
INE72_RS18410	COG1979	alcohol dehydrogenase
INE72_RS18420	COG0133	tryptophan synthase activity
INE72_RS18425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE72_RS18435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE72_RS18440	COG0134	indole-3-glycerol-phosphate synthase activity
INE72_RS18445	COG0135	phosphoribosylanthranilate isomerase activity
INE72_RS18450	COG0159	tryptophan synthase activity
INE72_RS18455	COG0252	asparaginase activity
INE72_RS18465	COG0745	RESPONSE REGULATOR receiver
INE72_RS18485	COG2197	response regulator
INE72_RS18495	COG0138	bifunctional purine biosynthesis protein purh
INE72_RS18505	COG0716	FMN binding
INE72_RS18525	COG4771	TonB-dependent receptor
INE72_RS18530	COG4771	TonB-dependent receptor
INE72_RS18540	COG0490	domain, Protein
INE72_RS18540	COG2985	domain, Protein
INE72_RS18555	COG4771	TonB-dependent receptor
INE72_RS18595	COG1609	Transcriptional regulator
INE72_RS18600	COG2721	sulfolactate sulfo-lyase activity
INE72_RS18625	COG1846	Transcriptional regulator
INE72_RS18640	COG4452	Inner membrane protein CreD
INE72_RS18650	COG2207	Transcriptional regulator
INE72_RS18665	COG1177	transmembrane transport
INE72_RS18670	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE72_RS18675	COG3842	ATPase activity
INE72_RS18680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE72_RS18690	COG0058	SHG alpha-glucan phosphorylase activity
INE72_RS18700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE72_RS18720	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE72_RS18775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE72_RS18780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE72_RS18785	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS18800	COG1295	ribonuclease BN
INE72_RS18805	COG0823	Involved in the tonB-independent uptake of proteins
INE72_RS18805	COG1506	peptidase
INE72_RS18805	COG4946	Tricorn protease homolog
INE72_RS18810	COG0778	Nitroreductase
INE72_RS18855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE72_RS18875	COG0704	Plays a role in the regulation of phosphate uptake
INE72_RS18880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE72_RS18885	COG0581	inorganic phosphate transmembrane transporter activity
INE72_RS18890	COG0573	inorganic phosphate transmembrane transporter activity
INE72_RS18900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE72_RS18910	COG0586	Pfam SNARE associated Golgi protein
INE72_RS18920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE72_RS18935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE72_RS18940	COG0167	dihydroorotate dehydrogenase activity
INE72_RS18945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE72_RS18985	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS19000	COG1215	transferase activity, transferring glycosyl groups
INE72_RS19005	COG0438	transferase activity, transferring glycosyl groups
INE72_RS19020	COG1216	Glycosyl transferase, family 2
INE72_RS19030	COG3385	transposase activity
INE72_RS19035	COG0110	maltose O-acetyltransferase activity
INE72_RS19205	COG3344	reverse transcriptase
INE72_RS19340	COG4974	Belongs to the 'phage' integrase family
INE72_RS19360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE72_RS19360	COG0551	DNA topoisomerase type I activity
INE72_RS19375	COG4804	nuclease activity
INE72_RS19405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE72_RS19410	COG0497	DNA recombination
INE72_RS19425	COG0592	DNA-directed DNA polymerase activity
INE72_RS19440	COG0321	lipoyl(octanoyl) transferase activity
INE72_RS19440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE72_RS19445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INE72_RS19455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE72_RS19460	COG0156	8-amino-7-oxononanoate synthase activity
INE72_RS19475	COG0019	diaminopimelate decarboxylase activity
INE72_RS19480	COG0527	aspartate kinase activity
INE72_RS19485	COG2884	Cell division ATP-binding protein ftsE
INE72_RS19490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE72_RS19490	COG0140	phosphoribosyl-ATP diphosphatase activity
INE72_RS19495	COG0107	imidazoleglycerol-phosphate synthase activity
INE72_RS19500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE72_RS19505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INE72_RS19510	COG0788	formyltetrahydrofolate deformylase activity
INE72_RS19525	COG0693	protein deglycase activity
INE72_RS19540	COG0534	Mate efflux family protein
INE72_RS19545	COG2076	Multidrug Resistance protein
INE72_RS19560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE72_RS19575	COG3831	ATPase activity
INE72_RS19575	COG4884	unkown
INE72_RS19580	COG2885	chlorophyll binding
INE72_RS19580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE72_RS19620	COG3546	catalase activity
INE72_RS19645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE72_RS19660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE72_RS19665	COG4946	Tricorn protease homolog
INE72_RS19665	COG1506	peptidase
INE72_RS19665	COG0823	Involved in the tonB-independent uptake of proteins
INE72_RS19670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE72_RS19675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INE72_RS19680	COG0778	Nitroreductase
INE72_RS19700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE72_RS19710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE72_RS19770	COG1312	Catalyzes the dehydration of D-mannonate
INE72_RS19775	COG1028	Short-chain dehydrogenase reductase Sdr
INE72_RS19780	COG1609	Transcriptional regulator
INE72_RS19800	COG2223	nitrite transmembrane transporter activity
INE72_RS19810	COG4771	TonB-dependent receptor
INE72_RS19820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INE72_RS19820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE72_RS19835	COG2226	methyltransferase
INE72_RS19845	COG0511	ligase activity, forming carbon-carbon bonds
INE72_RS19850	COG0439	Biotin carboxylase
INE72_RS19870	COG1620	l-lactate permease
INE72_RS19875	COG0456	acetyltransferase
INE72_RS19910	COG4771	TonB-dependent receptor
INE72_RS19930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE72_RS19945	COG1136	(ABC) transporter
INE72_RS19945	COG0577	efflux transmembrane transporter activity
INE72_RS19950	COG0577	efflux transmembrane transporter activity
INE72_RS19950	COG1136	(ABC) transporter
INE72_RS19960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS19975	COG3852	Histidine kinase
INE72_RS19980	COG0628	permease
INE72_RS19985	COG1215	transferase activity, transferring glycosyl groups
INE72_RS19990	COG1136	(ABC) transporter
INE72_RS19990	COG0577	efflux transmembrane transporter activity
INE72_RS19995	COG0436	Aminotransferase
INE72_RS20015	COG0488	(ABC) transporter
INE72_RS20030	COG0745	RESPONSE REGULATOR receiver
INE72_RS20035	COG5002	protein histidine kinase activity
INE72_RS20070	COG0629	single-stranded DNA binding
INE72_RS20075	COG1194	a g-specific adenine glycosylase
INE72_RS20085	COG1530	ribonuclease E activity
INE72_RS20105	COG4974	Belongs to the 'phage' integrase family
INE72_RS20160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE72_RS20165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS20175	COG4771	TonB-dependent receptor
INE72_RS20230	COG1120	ATPase activity
INE72_RS20235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE72_RS20305	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS20325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INE72_RS20335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
INE72_RS20350	COG4191	Histidine kinase
INE72_RS20355	COG2204	response regulator
INE72_RS20370	COG1136	(ABC) transporter
INE72_RS20390	COG1252	NADH dehydrogenase
INE72_RS20395	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE72_RS20400	COG0295	cytidine deaminase activity
INE72_RS20410	COG3059	membrane
INE72_RS20415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE72_RS20420	COG0488	(ABC) transporter
INE72_RS20445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE72_RS20480	COG4206	TonB-dependent receptor
INE72_RS20480	COG1629	transport
INE72_RS20525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE72_RS20530	COG1629	transport
INE72_RS20550	COG3250	beta-galactosidase activity
INE72_RS20555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INE72_RS20560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE72_RS20570	COG1595	DNA-templated transcription, initiation
INE72_RS20585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE72_RS20590	COG1741	Belongs to the pirin family
INE72_RS20595	COG0259	pyridoxamine-phosphate oxidase activity
INE72_RS20610	COG0346	lactoylglutathione lyase activity
INE72_RS20680	COG1918	ferrous iron import across plasma membrane
INE72_RS20680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE72_RS20685	COG0037	tRNA processing
INE72_RS20700	COG3119	arylsulfatase activity
INE72_RS20705	COG2202	Pas domain
INE72_RS20705	COG2205	protein histidine kinase activity
INE72_RS20710	COG2205	protein histidine kinase activity
INE72_RS20715	COG0534	Mate efflux family protein
INE72_RS20720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE72_RS20730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE72_RS20735	COG1858	cytochrome C peroxidase
INE72_RS20740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE72_RS20755	COG1983	PspC domain protein
INE72_RS20760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE72_RS20785	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE72_RS20795	COG0668	transmembrane transport
INE72_RS20805	COG3250	beta-galactosidase activity
INE72_RS20810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS20815	COG3119	arylsulfatase activity
INE72_RS20820	COG0702	epimerase
INE72_RS20825	COG4206	TonB-dependent receptor
INE72_RS20825	COG1629	transport
INE72_RS20830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE72_RS20840	COG0745	RESPONSE REGULATOR receiver
INE72_RS20840	COG3292	Two component regulator propeller
INE72_RS20840	COG0745	RESPONSE REGULATOR receiver
INE72_RS20840	COG2205	protein histidine kinase activity
INE72_RS20840	COG3292	Two component regulator propeller
INE72_RS20840	COG2205	protein histidine kinase activity
INE72_RS20845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INE72_RS20850	COG1830	Aldolase
INE72_RS20855	COG0588	phosphoglycerate mutase activity
INE72_RS20865	COG1119	ATPase activity
INE72_RS20870	COG1523	belongs to the glycosyl hydrolase 13 family
INE72_RS20875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE72_RS20905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INE72_RS20920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INE72_RS20930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE72_RS20935	COG2814	Major facilitator Superfamily
INE72_RS20940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE72_RS20945	COG0126	phosphoglycerate kinase activity
INE72_RS20960	COG2311	Membrane
INE72_RS20970	COG0424	maF-like protein
INE72_RS20990	COG0778	Nitroreductase
INE72_RS21000	COG0288	reversible hydration of carbon dioxide
INE72_RS21015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE72_RS21025	COG0511	ligase activity, forming carbon-carbon bonds
INE72_RS21030	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE72_RS21040	COG0191	fructose-bisphosphate aldolase activity
INE72_RS21045	COG0254	rRNA binding
INE72_RS21055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS21070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE72_RS21095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE72_RS21110	COG1280	lysine exporter protein (LysE YggA)
INE72_RS21115	COG0047	phosphoribosylformylglycinamidine synthase activity
INE72_RS21115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INE72_RS21120	COG2205	protein histidine kinase activity
INE72_RS21120	COG3292	Two component regulator propeller
INE72_RS21120	COG0745	RESPONSE REGULATOR receiver
INE72_RS21120	COG2205	protein histidine kinase activity
INE72_RS21120	COG3292	Two component regulator propeller
INE72_RS21120	COG0745	RESPONSE REGULATOR receiver
INE72_RS21135	COG1649	PFAM Uncharacterised BCR, COG1649
INE72_RS21155	COG1966	Carbon starvation protein
INE72_RS21160	COG1649	PFAM Uncharacterised BCR, COG1649
INE72_RS21185	COG2113	Glycine betaine
INE72_RS21190	COG4176	ABC-type proline glycine betaine transport system permease component
INE72_RS21215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE72_RS21215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE72_RS21225	COG1621	beta-fructofuranosidase activity
INE72_RS21245	COG1629	transport
INE72_RS21250	COG1621	beta-fructofuranosidase activity
INE72_RS21290	COG3279	Response regulator of the LytR AlgR family
INE72_RS21310	COG4772	TonB-dependent receptor
INE72_RS21330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE72_RS21335	COG1960	acyl-CoA dehydrogenase activity
INE72_RS21355	COG1956	GAF domain-containing protein
INE72_RS21370	COG0484	heat shock protein binding
INE72_RS21375	COG2194	sulfuric ester hydrolase activity
INE72_RS21395	COG0028	Belongs to the TPP enzyme family
INE72_RS21440	COG0459	protein refolding
INE72_RS21445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE72_RS21465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE72_RS21475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE72_RS21480	COG1506	peptidase
INE72_RS21480	COG0823	Involved in the tonB-independent uptake of proteins
INE72_RS21485	COG0124	histidyl-tRNA synthetase
INE72_RS21500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE72_RS21525	COG0514	ATP-dependent DNA helicase (RecQ)
INE72_RS21535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE72_RS21540	COG1368	sulfuric ester hydrolase activity
INE72_RS21545	COG0671	phosphoesterase, PA-phosphatase related
INE72_RS21550	COG0473	3-isopropylmalate dehydrogenase activity
INE72_RS21560	COG0066	3-isopropylmalate dehydratase activity
INE72_RS21565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE72_RS21570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE72_RS21615	COG4948	Mandelate Racemase Muconate Lactonizing
INE72_RS21620	COG0471	metal ion transport
INE72_RS21640	COG4771	TonB-dependent receptor
INE72_RS21670	COG0616	signal peptide processing
INE72_RS21675	COG1663	tetraacyldisaccharide 4'-kinase activity
INE72_RS21685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE72_RS21710	COG0513	Belongs to the DEAD box helicase family
INE72_RS21715	COG0724	RNA recognition motif
INE72_RS21755	COG4977	sequence-specific DNA binding
INE72_RS21755	COG1917	Cupin 2, conserved barrel domain protein
INE72_RS21770	COG1028	Short-chain dehydrogenase reductase Sdr
INE72_RS21775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INE72_RS21780	COG0456	acetyltransferase
INE72_RS21790	COG0439	Biotin carboxylase
INE72_RS21800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE72_RS21805	COG2855	membrane
INE72_RS21810	COG0745	RESPONSE REGULATOR receiver
INE72_RS21810	COG2205	protein histidine kinase activity
INE72_RS21810	COG3292	Two component regulator propeller
INE72_RS21820	COG1629	transport
INE72_RS21820	COG4206	TonB-dependent receptor
INE72_RS21865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE72_RS21910	COG0024	Methionine aminopeptidase
INE72_RS21915	COG3119	arylsulfatase activity
INE72_RS21920	COG3119	arylsulfatase activity
INE72_RS21925	COG0617	tRNA 3'-terminal CCA addition
INE72_RS21935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE72_RS21950	COG0632	four-way junction helicase activity
INE72_RS21955	COG0673	inositol 2-dehydrogenase activity
INE72_RS21970	COG1272	protein, Hemolysin III
INE72_RS21975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE72_RS21980	COG1328	CTP reductase activity
INE72_RS21990	COG2814	Major facilitator Superfamily
INE72_RS22000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE72_RS22015	COG0750	zinc metalloprotease
INE72_RS22020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE72_RS22030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE72_RS22035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE72_RS22045	COG1214	PFAM Peptidase M22, glycoprotease
INE72_RS22100	COG2433	Pfam Transposase IS66
INE72_RS22115	COG0194	GDP metabolic process
INE72_RS22120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE72_RS22125	COG1408	metallophosphoesterase
INE72_RS22130	COG1575	Belongs to the MenA family. Type 1 subfamily
INE72_RS22140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE72_RS22150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE72_RS22185	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE72_RS22195	COG2204	response regulator
INE72_RS22200	COG0488	(ABC) transporter
INE72_RS22210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS22225	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
INE72_RS22225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INE72_RS22245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE72_RS22250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE72_RS22260	COG1522	sequence-specific DNA binding
INE72_RS22290	COG0811	peptide transport
INE72_RS22300	COG0084	hydrolase, TatD family'
INE72_RS22320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE72_RS22325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE72_RS22330	COG0205	6-phosphofructokinase activity
INE72_RS22365	COG0372	Belongs to the citrate synthase family
INE72_RS22370	COG0538	isocitrate dehydrogenase activity
INE72_RS22375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE72_RS22380	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE72_RS22385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE72_RS22400	COG0028	Belongs to the TPP enzyme family
INE72_RS22405	COG0129	dihydroxy-acid dehydratase activity
INE72_RS22415	COG3681	Belongs to the UPF0597 family
INE72_RS22440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INE72_RS22470	COG4771	TonB-dependent receptor
INE72_RS22485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE72_RS22485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE72_RS22490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE72_RS22495	COG2985	domain, Protein
INE72_RS22495	COG0569	domain protein
INE72_RS22535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE72_RS22540	COG1120	ATPase activity
INE72_RS22555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE72_RS22560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE72_RS22570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE72_RS22575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE72_RS22580	COG0166	Belongs to the GPI family
INE72_RS22630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
INE72_RS22635	COG1028	Short-chain dehydrogenase reductase Sdr
INE72_RS22690	COG0438	transferase activity, transferring glycosyl groups
INE72_RS22720	COG1086	Polysaccharide biosynthesis protein
INE72_RS22755	COG2502	aspartate--ammonia ligase
INE72_RS22760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE72_RS22775	COG3876	Protein conserved in bacteria
INE72_RS22795	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE72_RS23060	COG5002	protein histidine kinase activity
INE72_RS23195	COG3119	arylsulfatase activity
INE72_RS23235	COG4372	Transposase
INE72_RS23240	COG2433	Pfam Transposase IS66