locus-tag	class	description
I6J49_RS00010	COG0210	DNA helicase
I6J49_RS00085	COG0681	Belongs to the peptidase S26 family
I6J49_RS00100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS00170	COG1082	Xylose isomerase domain protein TIM barrel
I6J49_RS00175	COG1022	Amp-dependent synthetase and ligase
I6J49_RS00180	COG3263	regulation of cellular component size
I6J49_RS00185	COG2233	PERMEase
I6J49_RS00190	COG1151	hydroxylamine reductase activity
I6J49_RS00210	COG0561	phosphatase activity
I6J49_RS00230	COG0577	efflux transmembrane transporter activity
I6J49_RS00230	COG1136	(ABC) transporter
I6J49_RS00240	COG0534	Mate efflux family protein
I6J49_RS00245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J49_RS00250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J49_RS00260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J49_RS00280	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6J49_RS00285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J49_RS00290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J49_RS00300	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J49_RS00305	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J49_RS00310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J49_RS00315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J49_RS00320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J49_RS00325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J49_RS00330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J49_RS00335	COG2431	L-lysine efflux transmembrane transporter activity
I6J49_RS00355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J49_RS00355	COG2207	Transcriptional regulator
I6J49_RS00380	COG2985	domain, Protein
I6J49_RS00385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J49_RS00390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J49_RS00405	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6J49_RS00410	COG0540	Belongs to the ATCase OTCase family
I6J49_RS00660	COG4974	Belongs to the 'phage' integrase family
I6J49_RS00710	COG1216	Glycosyl transferase, family 2
I6J49_RS00750	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS00760	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS00765	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS00790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J49_RS00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J49_RS00815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6J49_RS00830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J49_RS00835	COG2205	protein histidine kinase activity
I6J49_RS00870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J49_RS00885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J49_RS00905	COG0348	domain, Protein
I6J49_RS00910	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J49_RS00925	COG2326	polyphosphate kinase activity
I6J49_RS00950	COG0724	RNA recognition motif
I6J49_RS00955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J49_RS00960	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J49_RS00965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J49_RS00970	COG0351	phosphomethylpyrimidine kinase
I6J49_RS00985	COG2115	Belongs to the xylose isomerase family
I6J49_RS00990	COG2814	Major facilitator Superfamily
I6J49_RS00990	COG0477	Major facilitator Superfamily
I6J49_RS00995	COG3153	acetyltransferase
I6J49_RS00995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J49_RS01005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J49_RS01015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J49_RS01030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J49_RS01055	COG3015	lipoprotein NlpE involved in copper resistance
I6J49_RS01075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J49_RS01090	COG1904	glucuronate isomerase
I6J49_RS01100	COG0246	Mannitol dehydrogenase
I6J49_RS01130	COG0513	Belongs to the DEAD box helicase family
I6J49_RS01135	COG0560	Phosphoserine phosphatase
I6J49_RS01135	COG3830	Belongs to the UPF0237 family
I6J49_RS01155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J49_RS01160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J49_RS01220	COG1136	(ABC) transporter
I6J49_RS01220	COG0577	efflux transmembrane transporter activity
I6J49_RS01250	COG0156	8-amino-7-oxononanoate synthase activity
I6J49_RS01255	COG1597	lipid kinase activity
I6J49_RS01260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J49_RS01275	COG2957	Belongs to the agmatine deiminase family
I6J49_RS01305	COG4771	TonB-dependent receptor
I6J49_RS01310	COG0702	epimerase
I6J49_RS01330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J49_RS01340	COG1538	Outer membrane efflux protein
I6J49_RS01360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J49_RS01375	COG0543	2 iron, 2 sulfur cluster binding
I6J49_RS01380	COG0167	dihydroorotate dehydrogenase activity
I6J49_RS01385	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J49_RS01390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J49_RS01395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J49_RS01420	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J49_RS01425	COG0326	Molecular chaperone. Has ATPase activity
I6J49_RS01430	COG0542	response to heat
I6J49_RS01435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J49_RS01475	COG2304	oxidoreductase activity
I6J49_RS01490	COG0714	Associated with various cellular activities
I6J49_RS01500	COG0776	regulation of translation
I6J49_RS01505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J49_RS01510	COG0552	protein localization to endoplasmic reticulum
I6J49_RS01520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J49_RS01525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J49_RS01535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J49_RS01570	COG5002	protein histidine kinase activity
I6J49_RS01575	COG0745	RESPONSE REGULATOR receiver
I6J49_RS01580	COG0442	prolyl-tRNA aminoacylation
I6J49_RS01595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS01610	COG3292	Two component regulator propeller
I6J49_RS01610	COG2205	protein histidine kinase activity
I6J49_RS01610	COG0745	RESPONSE REGULATOR receiver
I6J49_RS01620	COG4771	TonB-dependent receptor
I6J49_RS01640	COG0738	Major facilitator superfamily
I6J49_RS01660	COG1011	Hydrolase
I6J49_RS01665	COG0300	oxidoreductase activity
I6J49_RS01680	COG2966	Psort location CytoplasmicMembrane, score
I6J49_RS01705	COG2205	protein histidine kinase activity
I6J49_RS01705	COG0784	Response regulator, receiver
I6J49_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
I6J49_RS01760	COG3537	Alpha-1,2-mannosidase
I6J49_RS01765	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J49_RS01775	COG1074	ATP-dependent DNA helicase activity
I6J49_RS01805	COG1475	DNA binding
I6J49_RS01810	COG3969	phosphoadenosine phosphosulfate
I6J49_RS01830	COG0305	Participates in initiation and elongation during chromosome replication
I6J49_RS01850	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS01865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J49_RS01905	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J49_RS01955	COG0505	Belongs to the CarA family
I6J49_RS01970	COG0070	glutamate synthase
I6J49_RS01970	COG0069	glutamate synthase activity
I6J49_RS01970	COG0067	glutamate synthase
I6J49_RS01980	COG0367	asparagine synthase
I6J49_RS02000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J49_RS02005	COG0436	Aminotransferase
I6J49_RS02025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J49_RS02040	COG0471	metal ion transport
I6J49_RS02040	COG0490	domain, Protein
I6J49_RS02045	COG1979	alcohol dehydrogenase
I6J49_RS02055	COG0133	tryptophan synthase activity
I6J49_RS02060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J49_RS02070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J49_RS02075	COG0134	indole-3-glycerol-phosphate synthase activity
I6J49_RS02080	COG0135	phosphoribosylanthranilate isomerase activity
I6J49_RS02085	COG0159	tryptophan synthase activity
I6J49_RS02090	COG0252	asparaginase activity
I6J49_RS02100	COG0745	RESPONSE REGULATOR receiver
I6J49_RS02120	COG2197	response regulator
I6J49_RS02130	COG0138	bifunctional purine biosynthesis protein purh
I6J49_RS02140	COG0716	FMN binding
I6J49_RS02160	COG4771	TonB-dependent receptor
I6J49_RS02165	COG4771	TonB-dependent receptor
I6J49_RS02175	COG0490	domain, Protein
I6J49_RS02175	COG2985	domain, Protein
I6J49_RS02190	COG4771	TonB-dependent receptor
I6J49_RS02230	COG1609	Transcriptional regulator
I6J49_RS02235	COG2721	sulfolactate sulfo-lyase activity
I6J49_RS02275	COG2207	Transcriptional regulator
I6J49_RS02290	COG1177	transmembrane transport
I6J49_RS02295	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J49_RS02300	COG3842	ATPase activity
I6J49_RS02305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS02315	COG0058	SHG alpha-glucan phosphorylase activity
I6J49_RS02325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J49_RS02345	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6J49_RS02400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J49_RS02405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J49_RS02410	COG4948	Mandelate Racemase Muconate Lactonizing
I6J49_RS02425	COG1295	ribonuclease BN
I6J49_RS02430	COG0823	Involved in the tonB-independent uptake of proteins
I6J49_RS02430	COG1506	peptidase
I6J49_RS02430	COG4946	Tricorn protease homolog
I6J49_RS02435	COG0778	Nitroreductase
I6J49_RS02445	COG0704	Plays a role in the regulation of phosphate uptake
I6J49_RS02450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J49_RS02455	COG0581	inorganic phosphate transmembrane transporter activity
I6J49_RS02460	COG0573	inorganic phosphate transmembrane transporter activity
I6J49_RS02490	COG1629	transport
I6J49_RS02490	COG4206	TonB-dependent receptor
I6J49_RS02500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J49_RS02510	COG0586	Pfam SNARE associated Golgi protein
I6J49_RS02520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J49_RS02535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J49_RS02540	COG0167	dihydroorotate dehydrogenase activity
I6J49_RS02545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J49_RS02590	COG2433	Pfam Transposase IS66
I6J49_RS02615	COG1215	transferase activity, transferring glycosyl groups
I6J49_RS02640	COG1216	Glycosyl transferase, family 2
I6J49_RS02645	COG1216	Glycosyl transferase, family 2
I6J49_RS02650	COG5039	Polysaccharide pyruvyl transferase
I6J49_RS02700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J49_RS02705	COG0497	DNA recombination
I6J49_RS02720	COG0592	DNA-directed DNA polymerase activity
I6J49_RS02735	COG0321	lipoyl(octanoyl) transferase activity
I6J49_RS02735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J49_RS02740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J49_RS02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J49_RS02755	COG0156	8-amino-7-oxononanoate synthase activity
I6J49_RS02770	COG0019	diaminopimelate decarboxylase activity
I6J49_RS02775	COG0527	aspartate kinase activity
I6J49_RS02780	COG2884	Cell division ATP-binding protein ftsE
I6J49_RS02785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J49_RS02785	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J49_RS02790	COG0107	imidazoleglycerol-phosphate synthase activity
I6J49_RS02795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J49_RS02800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J49_RS02805	COG0788	formyltetrahydrofolate deformylase activity
I6J49_RS02820	COG0693	protein deglycase activity
I6J49_RS02835	COG0534	Mate efflux family protein
I6J49_RS02840	COG2076	Multidrug Resistance protein
I6J49_RS02855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J49_RS02870	COG3831	ATPase activity
I6J49_RS02870	COG4884	unkown
I6J49_RS02875	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J49_RS02875	COG2885	chlorophyll binding
I6J49_RS02915	COG3546	catalase activity
I6J49_RS02940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J49_RS02955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J49_RS02960	COG4946	Tricorn protease homolog
I6J49_RS02960	COG1506	peptidase
I6J49_RS02960	COG0823	Involved in the tonB-independent uptake of proteins
I6J49_RS02970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J49_RS02975	COG0778	Nitroreductase
I6J49_RS03000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J49_RS03005	COG4804	nuclease activity
I6J49_RS03010	COG0732	type I restriction modification DNA specificity domain
I6J49_RS03025	COG0732	type I restriction modification DNA specificity domain
I6J49_RS03060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J49_RS03070	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J49_RS03085	COG4771	TonB-dependent receptor
I6J49_RS03130	COG1312	Catalyzes the dehydration of D-mannonate
I6J49_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J49_RS03140	COG1609	Transcriptional regulator
I6J49_RS03160	COG2223	nitrite transmembrane transporter activity
I6J49_RS03170	COG4771	TonB-dependent receptor
I6J49_RS03180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J49_RS03180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J49_RS03195	COG2226	methyltransferase
I6J49_RS03205	COG0511	ligase activity, forming carbon-carbon bonds
I6J49_RS03210	COG0439	Biotin carboxylase
I6J49_RS03215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J49_RS03230	COG1620	l-lactate permease
I6J49_RS03275	COG4771	TonB-dependent receptor
I6J49_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J49_RS03310	COG1136	(ABC) transporter
I6J49_RS03310	COG0577	efflux transmembrane transporter activity
I6J49_RS03315	COG1136	(ABC) transporter
I6J49_RS03315	COG0577	efflux transmembrane transporter activity
I6J49_RS03325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS03340	COG3852	Histidine kinase
I6J49_RS03345	COG0628	permease
I6J49_RS03350	COG1215	transferase activity, transferring glycosyl groups
I6J49_RS03355	COG0577	efflux transmembrane transporter activity
I6J49_RS03355	COG1136	(ABC) transporter
I6J49_RS03360	COG0436	Aminotransferase
I6J49_RS03380	COG0488	(ABC) transporter
I6J49_RS03395	COG0745	RESPONSE REGULATOR receiver
I6J49_RS03400	COG5002	protein histidine kinase activity
I6J49_RS03435	COG0629	single-stranded DNA binding
I6J49_RS03440	COG1194	a g-specific adenine glycosylase
I6J49_RS03450	COG1530	ribonuclease E activity
I6J49_RS03495	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS03515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J49_RS03525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J49_RS03540	COG4191	Histidine kinase
I6J49_RS03545	COG2204	response regulator
I6J49_RS03560	COG1136	(ABC) transporter
I6J49_RS03580	COG1252	NADH dehydrogenase
I6J49_RS03585	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J49_RS03590	COG0295	cytidine deaminase activity
I6J49_RS03600	COG3059	membrane
I6J49_RS03605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J49_RS03610	COG0488	(ABC) transporter
I6J49_RS03635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J49_RS03670	COG1629	transport
I6J49_RS03670	COG4206	TonB-dependent receptor
I6J49_RS03720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J49_RS03725	COG1629	transport
I6J49_RS03745	COG3250	beta-galactosidase activity
I6J49_RS03750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J49_RS03755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J49_RS03765	COG1595	DNA-templated transcription, initiation
I6J49_RS03780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J49_RS03785	COG1741	Belongs to the pirin family
I6J49_RS03790	COG0259	pyridoxamine-phosphate oxidase activity
I6J49_RS03805	COG0346	lactoylglutathione lyase activity
I6J49_RS03870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J49_RS03870	COG1918	ferrous iron import across plasma membrane
I6J49_RS03875	COG0037	tRNA processing
I6J49_RS03890	COG3119	arylsulfatase activity
I6J49_RS03895	COG2202	Pas domain
I6J49_RS03895	COG2205	protein histidine kinase activity
I6J49_RS03900	COG2205	protein histidine kinase activity
I6J49_RS03905	COG0534	Mate efflux family protein
I6J49_RS03910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J49_RS03920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J49_RS03925	COG1858	cytochrome C peroxidase
I6J49_RS03930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J49_RS03945	COG1983	PspC domain protein
I6J49_RS03950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J49_RS03975	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J49_RS03985	COG0668	transmembrane transport
I6J49_RS03995	COG3250	beta-galactosidase activity
I6J49_RS04000	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS04005	COG3119	arylsulfatase activity
I6J49_RS04010	COG0702	epimerase
I6J49_RS04015	COG1629	transport
I6J49_RS04015	COG4206	TonB-dependent receptor
I6J49_RS04020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J49_RS04030	COG2205	protein histidine kinase activity
I6J49_RS04030	COG3292	Two component regulator propeller
I6J49_RS04030	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04030	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04030	COG2205	protein histidine kinase activity
I6J49_RS04030	COG3292	Two component regulator propeller
I6J49_RS04035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J49_RS04040	COG1830	Aldolase
I6J49_RS04045	COG0588	phosphoglycerate mutase activity
I6J49_RS04055	COG1119	ATPase activity
I6J49_RS04060	COG1523	belongs to the glycosyl hydrolase 13 family
I6J49_RS04065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J49_RS04090	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS04105	COG3250	beta-galactosidase activity
I6J49_RS04115	COG3408	Glycogen debranching enzyme
I6J49_RS04125	COG1629	transport
I6J49_RS04125	COG4206	TonB-dependent receptor
I6J49_RS04150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS04180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J49_RS04195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J49_RS04205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J49_RS04210	COG2814	Major facilitator Superfamily
I6J49_RS04215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J49_RS04220	COG0126	phosphoglycerate kinase activity
I6J49_RS04235	COG2311	Membrane
I6J49_RS04245	COG0424	maF-like protein
I6J49_RS04265	COG0778	Nitroreductase
I6J49_RS04275	COG0288	reversible hydration of carbon dioxide
I6J49_RS04290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J49_RS04300	COG0511	ligase activity, forming carbon-carbon bonds
I6J49_RS04305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J49_RS04315	COG0191	fructose-bisphosphate aldolase activity
I6J49_RS04320	COG0254	rRNA binding
I6J49_RS04330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS04345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J49_RS04370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J49_RS04385	COG1280	lysine exporter protein (LysE YggA)
I6J49_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J49_RS04390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J49_RS04395	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04395	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04395	COG2205	protein histidine kinase activity
I6J49_RS04395	COG3292	Two component regulator propeller
I6J49_RS04395	COG3292	Two component regulator propeller
I6J49_RS04395	COG2205	protein histidine kinase activity
I6J49_RS04410	COG1649	PFAM Uncharacterised BCR, COG1649
I6J49_RS04430	COG1966	Carbon starvation protein
I6J49_RS04435	COG1649	PFAM Uncharacterised BCR, COG1649
I6J49_RS04460	COG2113	Glycine betaine
I6J49_RS04465	COG4176	ABC-type proline glycine betaine transport system permease component
I6J49_RS04485	COG3292	Two component regulator propeller
I6J49_RS04485	COG2205	protein histidine kinase activity
I6J49_RS04485	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J49_RS04490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J49_RS04500	COG1621	beta-fructofuranosidase activity
I6J49_RS04520	COG1629	transport
I6J49_RS04525	COG1621	beta-fructofuranosidase activity
I6J49_RS04565	COG3279	Response regulator of the LytR AlgR family
I6J49_RS04585	COG4772	TonB-dependent receptor
I6J49_RS04605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J49_RS04610	COG1960	acyl-CoA dehydrogenase activity
I6J49_RS04630	COG1956	GAF domain-containing protein
I6J49_RS04640	COG0484	heat shock protein binding
I6J49_RS04645	COG2194	sulfuric ester hydrolase activity
I6J49_RS04665	COG0028	Belongs to the TPP enzyme family
I6J49_RS04710	COG0459	protein refolding
I6J49_RS04715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J49_RS04735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J49_RS04745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J49_RS04750	COG1506	peptidase
I6J49_RS04750	COG0823	Involved in the tonB-independent uptake of proteins
I6J49_RS04755	COG0124	histidyl-tRNA synthetase
I6J49_RS04770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J49_RS04795	COG0514	ATP-dependent DNA helicase (RecQ)
I6J49_RS04805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J49_RS04810	COG1368	sulfuric ester hydrolase activity
I6J49_RS04815	COG0671	phosphoesterase, PA-phosphatase related
I6J49_RS04820	COG0473	3-isopropylmalate dehydrogenase activity
I6J49_RS04830	COG0066	3-isopropylmalate dehydratase activity
I6J49_RS04835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J49_RS04840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J49_RS04885	COG4948	Mandelate Racemase Muconate Lactonizing
I6J49_RS04890	COG0471	metal ion transport
I6J49_RS04895	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04895	COG2205	protein histidine kinase activity
I6J49_RS04895	COG0745	RESPONSE REGULATOR receiver
I6J49_RS04895	COG3292	Two component regulator propeller
I6J49_RS04895	COG2205	protein histidine kinase activity
I6J49_RS04895	COG3292	Two component regulator propeller
I6J49_RS04910	COG4771	TonB-dependent receptor
I6J49_RS04940	COG0616	signal peptide processing
I6J49_RS04945	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J49_RS04955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J49_RS04980	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS04985	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS04995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS05000	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS05010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS05020	COG0702	epimerase
I6J49_RS05025	COG1629	transport
I6J49_RS05035	COG1629	transport
I6J49_RS05055	COG3292	Two component regulator propeller
I6J49_RS05055	COG2205	protein histidine kinase activity
I6J49_RS05055	COG0745	RESPONSE REGULATOR receiver
I6J49_RS05070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J49_RS05070	COG0551	DNA topoisomerase type I activity
I6J49_RS05145	COG0513	Belongs to the DEAD box helicase family
I6J49_RS05150	COG0724	RNA recognition motif
I6J49_RS05195	COG1917	Cupin 2, conserved barrel domain protein
I6J49_RS05195	COG4977	sequence-specific DNA binding
I6J49_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J49_RS05215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J49_RS05220	COG0456	acetyltransferase
I6J49_RS05230	COG0439	Biotin carboxylase
I6J49_RS05240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J49_RS05245	COG2855	membrane
I6J49_RS05250	COG2205	protein histidine kinase activity
I6J49_RS05250	COG0745	RESPONSE REGULATOR receiver
I6J49_RS05250	COG3292	Two component regulator propeller
I6J49_RS05260	COG4206	TonB-dependent receptor
I6J49_RS05260	COG1629	transport
I6J49_RS05305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J49_RS05350	COG0024	Methionine aminopeptidase
I6J49_RS05355	COG3119	arylsulfatase activity
I6J49_RS05360	COG3119	arylsulfatase activity
I6J49_RS05365	COG0617	tRNA 3'-terminal CCA addition
I6J49_RS05375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS05390	COG0632	four-way junction helicase activity
I6J49_RS05395	COG0673	inositol 2-dehydrogenase activity
I6J49_RS05410	COG1272	protein, Hemolysin III
I6J49_RS05415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J49_RS05420	COG1328	CTP reductase activity
I6J49_RS05430	COG2814	Major facilitator Superfamily
I6J49_RS05440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J49_RS05455	COG0750	zinc metalloprotease
I6J49_RS05460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J49_RS05470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J49_RS05475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J49_RS05485	COG1214	PFAM Peptidase M22, glycoprotease
I6J49_RS05535	COG0194	GDP metabolic process
I6J49_RS05540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J49_RS05545	COG1408	metallophosphoesterase
I6J49_RS05550	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J49_RS05560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J49_RS05570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J49_RS05605	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS05615	COG2204	response regulator
I6J49_RS05620	COG0488	(ABC) transporter
I6J49_RS05630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS05645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J49_RS05645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J49_RS05665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J49_RS05670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J49_RS05680	COG1522	sequence-specific DNA binding
I6J49_RS05710	COG0811	peptide transport
I6J49_RS05720	COG0084	hydrolase, TatD family'
I6J49_RS05740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J49_RS05745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J49_RS05750	COG0205	6-phosphofructokinase activity
I6J49_RS05765	COG4206	TonB-dependent receptor
I6J49_RS05785	COG0372	Belongs to the citrate synthase family
I6J49_RS05790	COG0538	isocitrate dehydrogenase activity
I6J49_RS05795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J49_RS05800	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J49_RS05805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J49_RS05820	COG0028	Belongs to the TPP enzyme family
I6J49_RS05825	COG0129	dihydroxy-acid dehydratase activity
I6J49_RS05835	COG3681	Belongs to the UPF0597 family
I6J49_RS05860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J49_RS05890	COG4771	TonB-dependent receptor
I6J49_RS05905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J49_RS05905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J49_RS05910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J49_RS05915	COG0569	domain protein
I6J49_RS05915	COG2985	domain, Protein
I6J49_RS05955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J49_RS05960	COG1120	ATPase activity
I6J49_RS05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS05990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J49_RS05995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J49_RS06000	COG0166	Belongs to the GPI family
I6J49_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J49_RS06040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J49_RS06055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J49_RS06060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J49_RS06085	COG2843	Capsule synthesis protein
I6J49_RS06110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J49_RS06115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J49_RS06125	COG1086	Polysaccharide biosynthesis protein
I6J49_RS06155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J49_RS06160	COG1388	LysM domain
I6J49_RS06160	COG4641	Protein conserved in bacteria
I6J49_RS06225	COG2502	aspartate--ammonia ligase
I6J49_RS06230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J49_RS06245	COG3876	Protein conserved in bacteria
I6J49_RS06270	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS06280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J49_RS06285	COG0778	Nitroreductase
I6J49_RS06295	COG1640	4-alpha-glucanotransferase
I6J49_RS06300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J49_RS06320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J49_RS06325	COG1022	Amp-dependent synthetase and ligase
I6J49_RS06360	COG0359	binds to the 23S rRNA
I6J49_RS06365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J49_RS06370	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J49_RS06395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J49_RS06400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J49_RS06425	COG1131	(ABC) transporter
I6J49_RS06435	COG2431	L-lysine efflux transmembrane transporter activity
I6J49_RS06455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J49_RS06460	COG4771	TonB-dependent receptor
I6J49_RS06490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J49_RS06495	COG0802	atpase or kinase
I6J49_RS06510	COG0714	Associated with various cellular activities
I6J49_RS06545	COG3118	belongs to the thioredoxin family
I6J49_RS06555	COG0688	phosphatidylethanolamine metabolic process
I6J49_RS06560	COG1183	phosphatidylcholine synthase activity
I6J49_RS06580	COG0792	nuclease activity
I6J49_RS06605	COG0534	Mate efflux family protein
I6J49_RS06610	COG0528	UMP kinase activity
I6J49_RS06620	COG0233	cytoplasmic translational termination
I6J49_RS06625	COG1162	GTPase activity
I6J49_RS06635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J49_RS06650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J49_RS06650	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J49_RS06660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J49_RS06675	COG1629	transport
I6J49_RS06685	COG1629	transport
I6J49_RS06685	COG4206	TonB-dependent receptor
I6J49_RS06695	COG2095	MarC family integral membrane protein
I6J49_RS06710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J49_RS06720	COG1785	Belongs to the alkaline phosphatase family
I6J49_RS06730	COG4206	TonB-dependent receptor
I6J49_RS06730	COG1629	transport
I6J49_RS06735	COG1435	thymidine kinase activity
I6J49_RS06740	COG0628	permease
I6J49_RS06760	COG2433	Pfam Transposase IS66
I6J49_RS06810	COG3973	AAA domain
I6J49_RS06845	COG0456	acetyltransferase
I6J49_RS06855	COG4974	Belongs to the 'phage' integrase family
I6J49_RS06860	COG0582	viral genome integration into host DNA
I6J49_RS06890	COG2223	nitrite transmembrane transporter activity
I6J49_RS06900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J49_RS06905	COG2197	response regulator
I6J49_RS06920	COG2205	protein histidine kinase activity
I6J49_RS06920	COG2198	Histidine kinase
I6J49_RS06920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J49_RS06920	COG0784	Response regulator, receiver
I6J49_RS06955	COG0702	epimerase
I6J49_RS06960	COG4771	TonB-dependent receptor
I6J49_RS06965	COG2205	protein histidine kinase activity
I6J49_RS06965	COG3292	Two component regulator propeller
I6J49_RS06965	COG0745	RESPONSE REGULATOR receiver
I6J49_RS07000	COG0589	response to stress
I6J49_RS07000	COG0475	glutathione-regulated potassium exporter activity
I6J49_RS07015	COG3292	Two component regulator propeller
I6J49_RS07015	COG2205	protein histidine kinase activity
I6J49_RS07015	COG0745	RESPONSE REGULATOR receiver
I6J49_RS07020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J49_RS07025	COG4771	TonB-dependent receptor
I6J49_RS07105	COG0534	Mate efflux family protein
I6J49_RS07120	COG0826	peptidase U32
I6J49_RS07125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6J49_RS07135	COG0436	Aminotransferase
I6J49_RS07140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J49_RS07205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J49_RS07240	COG4974	Belongs to the 'phage' integrase family
I6J49_RS07260	COG1629	transport
I6J49_RS07260	COG4206	TonB-dependent receptor
I6J49_RS07265	COG0702	epimerase
I6J49_RS07270	COG3250	beta-galactosidase activity
I6J49_RS07275	COG3420	alginic acid biosynthetic process
I6J49_RS07280	COG0519	Catalyzes the synthesis of GMP from XMP
I6J49_RS07285	COG5002	protein histidine kinase activity
I6J49_RS07290	COG2205	protein histidine kinase activity
I6J49_RS07300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J49_RS07310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J49_RS07320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J49_RS07355	COG2204	response regulator
I6J49_RS07360	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J49_RS07380	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS07385	COG0737	Belongs to the 5'-nucleotidase family
I6J49_RS07395	COG0335	large ribosomal subunit rRNA binding
I6J49_RS07400	COG1940	carbohydrate kinase activity
I6J49_RS07405	COG0577	efflux transmembrane transporter activity
I6J49_RS07405	COG1136	(ABC) transporter
I6J49_RS07410	COG0577	efflux transmembrane transporter activity
I6J49_RS07410	COG1136	(ABC) transporter
I6J49_RS07415	COG1136	(ABC) transporter
I6J49_RS07415	COG0577	efflux transmembrane transporter activity
I6J49_RS07430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J49_RS07430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J49_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J49_RS07455	COG2996	Protein conserved in bacteria
I6J49_RS07460	COG0039	L-malate dehydrogenase activity
I6J49_RS07470	COG2217	Heavy metal translocating P-type atpase
I6J49_RS07480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J49_RS07485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J49_RS07490	COG0509	glycine decarboxylation via glycine cleavage system
I6J49_RS07505	COG0006	proline dipeptidase activity
I6J49_RS07520	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J49_RS07530	COG1773	rubredoxin
I6J49_RS07540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J49_RS07545	COG1011	Hydrolase
I6J49_RS07550	COG0196	riboflavin kinase activity
I6J49_RS07555	COG1266	CAAX protease self-immunity
I6J49_RS07565	COG0612	Peptidase, M16
I6J49_RS07585	COG2166	iron-sulfur cluster assembly
I6J49_RS07590	COG2234	aminopeptidase activity
I6J49_RS07595	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J49_RS07605	COG0280	phosphate acetyltransferase
I6J49_RS07610	COG3426	butyrate kinase activity
I6J49_RS07630	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J49_RS07640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J49_RS07660	COG1595	DNA-templated transcription, initiation
I6J49_RS07665	COG0076	glutamate decarboxylase activity
I6J49_RS07670	COG2066	Belongs to the glutaminase family
I6J49_RS07680	COG0531	amino acid
I6J49_RS07710	COG1725	Transcriptional regulator
I6J49_RS07720	COG1131	(ABC) transporter
I6J49_RS07790	COG0673	inositol 2-dehydrogenase activity
I6J49_RS07805	COG3420	alginic acid biosynthetic process
I6J49_RS07820	COG0702	epimerase
I6J49_RS07825	COG4771	TonB-dependent receptor
I6J49_RS07840	COG0667	Aldo Keto reductase
I6J49_RS07845	COG1696	Membrane protein involved in D-alanine export
I6J49_RS07880	COG1309	transcriptional regulator
I6J49_RS07885	COG2986	histidine ammonia-lyase
I6J49_RS07910	COG0203	ribosomal protein L17
I6J49_RS07915	COG0202	RNA polymerase activity
I6J49_RS07920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J49_RS07925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J49_RS07930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J49_RS07935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J49_RS07940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J49_RS07955	COG0200	Binds to the 23S rRNA
I6J49_RS07960	COG1841	ribosomal large subunit assembly
I6J49_RS07965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J49_RS07970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J49_RS07975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J49_RS07980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J49_RS07985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J49_RS07990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J49_RS07995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J49_RS08000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J49_RS08005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J49_RS08010	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J49_RS08015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J49_RS08020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J49_RS08025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J49_RS08030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J49_RS08035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J49_RS08040	COG0089	rRNA binding
I6J49_RS08045	COG0088	Forms part of the polypeptide exit tunnel
I6J49_RS08050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J49_RS08055	COG0051	transcription antitermination factor activity, RNA binding
I6J49_RS08060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J49_RS08065	COG0049	tRNA binding
I6J49_RS08070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J49_RS08080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J49_RS08085	COG0085	RNA polymerase activity
I6J49_RS08090	COG0222	ribosome binding
I6J49_RS08095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J49_RS08100	COG0081	regulation of translation
I6J49_RS08105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J49_RS08115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J49_RS08125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J49_RS08155	COG4974	Belongs to the 'phage' integrase family
I6J49_RS08160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J49_RS08165	COG0006	proline dipeptidase activity
I6J49_RS08170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J49_RS08180	COG3118	belongs to the thioredoxin family
I6J49_RS08190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J49_RS08200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J49_RS08210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J49_RS08225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J49_RS08230	COG1027	Aspartate ammonia-lyase
I6J49_RS08235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J49_RS08240	COG0252	asparaginase activity
I6J49_RS08265	COG4771	TonB-dependent receptor
I6J49_RS08280	COG3119	arylsulfatase activity
I6J49_RS08310	COG4974	Belongs to the 'phage' integrase family
I6J49_RS08330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J49_RS08375	COG2096	Adenosyltransferase
I6J49_RS08400	COG4804	nuclease activity
I6J49_RS08405	COG4804	nuclease activity
I6J49_RS08415	COG1051	belongs to the nudix hydrolase family
I6J49_RS08420	COG0546	phosphoglycolate phosphatase activity
I6J49_RS08440	COG0662	Cupin 2, conserved barrel domain protein
I6J49_RS08440	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J49_RS08445	COG0318	PFAM AMP-dependent synthetase and ligase
I6J49_RS08450	COG1396	sequence-specific DNA binding
I6J49_RS08455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J49_RS08460	COG1217	gtp-binding protein TYPA
I6J49_RS08475	COG2059	Chromate
I6J49_RS08485	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J49_RS08505	COG1629	transport
I6J49_RS08535	COG1595	DNA-templated transcription, initiation
I6J49_RS08540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J49_RS08545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J49_RS08575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J49_RS08585	COG0793	Belongs to the peptidase S41A family
I6J49_RS08590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J49_RS08625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J49_RS08630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J49_RS08640	COG1629	transport
I6J49_RS08645	COG0702	epimerase
I6J49_RS08670	COG4948	Mandelate Racemase Muconate Lactonizing
I6J49_RS08680	COG3634	alkyl hydroperoxide reductase activity
I6J49_RS08690	COG1629	transport
I6J49_RS08695	COG0702	epimerase
I6J49_RS08705	COG0745	RESPONSE REGULATOR receiver
I6J49_RS08705	COG3292	Two component regulator propeller
I6J49_RS08705	COG2205	protein histidine kinase activity
I6J49_RS08710	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J49_RS08720	COG2816	NAD+ diphosphatase activity
I6J49_RS08740	COG1629	transport
I6J49_RS08750	COG4771	TonB-dependent receptor
I6J49_RS08775	COG0745	RESPONSE REGULATOR receiver
I6J49_RS08775	COG2205	protein histidine kinase activity
I6J49_RS08775	COG3292	Two component regulator propeller
I6J49_RS08775	COG0745	RESPONSE REGULATOR receiver
I6J49_RS08775	COG2205	protein histidine kinase activity
I6J49_RS08775	COG3292	Two component regulator propeller
I6J49_RS08790	COG0018	arginyl-trna synthetase
I6J49_RS08800	COG0705	Rhomboid family
I6J49_RS08815	COG0339	signal peptide processing
I6J49_RS08820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J49_RS08830	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J49_RS08830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J49_RS08835	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J49_RS08850	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J49_RS08855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J49_RS08875	COG4974	Belongs to the 'phage' integrase family
I6J49_RS08900	COG0606	chelatase, subunit chli
I6J49_RS08915	COG3940	Belongs to the glycosyl hydrolase 43 family
I6J49_RS08920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS08925	COG3119	arylsulfatase activity
I6J49_RS08945	COG4771	TonB-dependent receptor
I6J49_RS08955	COG3250	beta-galactosidase activity
I6J49_RS08970	COG0702	epimerase
I6J49_RS08975	COG1629	transport
I6J49_RS08975	COG4206	TonB-dependent receptor
I6J49_RS08980	COG3292	Two component regulator propeller
I6J49_RS08980	COG2205	protein histidine kinase activity
I6J49_RS08980	COG0745	RESPONSE REGULATOR receiver
I6J49_RS09055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J49_RS09055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J49_RS09075	COG3475	LICD family
I6J49_RS09090	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS09105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS09120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS09140	COG3250	beta-galactosidase activity
I6J49_RS09160	COG1629	transport
I6J49_RS09165	COG3250	beta-galactosidase activity
I6J49_RS09175	COG2205	protein histidine kinase activity
I6J49_RS09175	COG3292	Two component regulator propeller
I6J49_RS09175	COG0745	RESPONSE REGULATOR receiver
I6J49_RS09195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J49_RS09200	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J49_RS09205	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J49_RS09230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J49_RS09265	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J49_RS09270	COG4771	TonB-dependent receptor
I6J49_RS09275	COG0702	epimerase
I6J49_RS09280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J49_RS09305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J49_RS09310	COG0793	Belongs to the peptidase S41A family
I6J49_RS09310	COG3409	Peptidoglycan-binding domain 1 protein
I6J49_RS09320	COG3119	arylsulfatase activity
I6J49_RS09335	COG1053	succinate dehydrogenase
I6J49_RS09340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J49_RS09375	COG0582	viral genome integration into host DNA
I6J49_RS09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J49_RS09400	COG0758	DNA mediated transformation
I6J49_RS09410	COG0826	peptidase U32
I6J49_RS09415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J49_RS09430	COG0557	exoribonuclease II activity
I6J49_RS09440	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS09455	COG1917	Cupin 2, conserved barrel domain protein
I6J49_RS09460	COG1073	alpha beta
I6J49_RS09465	COG2814	Major facilitator Superfamily
I6J49_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
I6J49_RS09475	COG0012	GTP binding
I6J49_RS09480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J49_RS09485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J49_RS09490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J49_RS09495	COG3250	beta-galactosidase activity
I6J49_RS09510	COG1629	transport
I6J49_RS09510	COG4206	TonB-dependent receptor
I6J49_RS09525	COG0697	spore germination
I6J49_RS09530	COG0495	leucyl-tRNA aminoacylation
I6J49_RS09535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J49_RS09540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J49_RS09545	COG1360	Flagellar Motor Protein
I6J49_RS09555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS09565	COG3292	Two component regulator propeller
I6J49_RS09565	COG2205	protein histidine kinase activity
I6J49_RS09565	COG0745	RESPONSE REGULATOR receiver
I6J49_RS09590	COG4771	TonB-dependent receptor
I6J49_RS09595	COG0561	phosphatase activity
I6J49_RS09600	COG4771	TonB-dependent receptor
I6J49_RS09615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J49_RS09645	COG4771	TonB-dependent receptor
I6J49_RS09670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS09680	COG0731	radical SAM domain protein
I6J49_RS09680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J49_RS09695	COG4771	TonB-dependent receptor
I6J49_RS09740	COG1629	transport
I6J49_RS09760	COG3119	arylsulfatase activity
I6J49_RS09765	COG3119	arylsulfatase activity
I6J49_RS09770	COG3119	arylsulfatase activity
I6J49_RS09775	COG3119	arylsulfatase activity
I6J49_RS09785	COG3119	arylsulfatase activity
I6J49_RS09795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J49_RS09800	COG0659	secondary active sulfate transmembrane transporter activity
I6J49_RS09805	COG1592	Rubrerythrin
I6J49_RS09845	COG0427	acetyl-CoA hydrolase
I6J49_RS09855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J49_RS09865	COG2177	Part of the ABC transporter FtsEX involved in
I6J49_RS09875	COG1968	undecaprenyl-diphosphatase activity
I6J49_RS09880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J49_RS09885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J49_RS09890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J49_RS09900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J49_RS09950	COG0594	ribonuclease P activity
I6J49_RS09955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J49_RS09960	COG0084	hydrolase, TatD family'
I6J49_RS09965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J49_RS09975	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6J49_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
I6J49_RS10040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J49_RS10055	COG1121	(ABC) transporter
I6J49_RS10065	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6J49_RS10065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J49_RS10090	COG0823	Involved in the tonB-independent uptake of proteins
I6J49_RS10090	COG1506	peptidase
I6J49_RS10095	COG0116	Belongs to the methyltransferase superfamily
I6J49_RS10095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J49_RS10100	COG1045	serine acetyltransferase
I6J49_RS10105	COG3275	phosphorelay sensor kinase activity
I6J49_RS10110	COG3279	Response regulator of the LytR AlgR family
I6J49_RS10120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J49_RS10120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J49_RS10125	COG0142	geranyltranstransferase activity
I6J49_RS10135	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J49_RS10140	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J49_RS10145	COG1490	D-aminoacyl-tRNA deacylase activity
I6J49_RS10150	COG0322	excinuclease ABC activity
I6J49_RS10155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J49_RS10160	COG0445	tRNA wobble uridine modification
I6J49_RS10175	COG4771	TonB-dependent receptor
I6J49_RS10215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J49_RS10220	COG2715	membrane protein required for spore maturation
I6J49_RS10225	COG2255	four-way junction helicase activity
I6J49_RS10230	COG2852	Protein conserved in bacteria
I6J49_RS10245	COG3591	Belongs to the peptidase S1B family
I6J49_RS10250	COG0513	Belongs to the DEAD box helicase family
I6J49_RS10270	COG0612	Peptidase, M16
I6J49_RS10280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS10285	COG1629	transport
I6J49_RS10310	COG0673	inositol 2-dehydrogenase activity
I6J49_RS10315	COG2205	protein histidine kinase activity
I6J49_RS10315	COG0745	RESPONSE REGULATOR receiver
I6J49_RS10315	COG3292	Two component regulator propeller
I6J49_RS10325	COG0681	Belongs to the peptidase S26 family
I6J49_RS10335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J49_RS10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS10370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J49_RS10375	COG4771	TonB-dependent receptor
I6J49_RS10410	COG3119	arylsulfatase activity
I6J49_RS10415	COG2205	protein histidine kinase activity
I6J49_RS10415	COG3292	Two component regulator propeller
I6J49_RS10415	COG3292	Two component regulator propeller
I6J49_RS10415	COG0745	RESPONSE REGULATOR receiver
I6J49_RS10415	COG0745	RESPONSE REGULATOR receiver
I6J49_RS10415	COG2205	protein histidine kinase activity
I6J49_RS10425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J49_RS10430	COG1538	Outer membrane efflux protein
I6J49_RS10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS10445	COG3250	beta-galactosidase activity
I6J49_RS10450	COG4771	TonB-dependent receptor
I6J49_RS10465	COG0702	epimerase
I6J49_RS10485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS10490	COG3119	arylsulfatase activity
I6J49_RS10495	COG5492	domain, Protein
I6J49_RS10500	COG0215	cysteine-tRNA ligase activity
I6J49_RS10505	COG0561	phosphatase activity
I6J49_RS10515	COG0482	sulfurtransferase activity
I6J49_RS10525	COG0205	6-phosphofructokinase activity
I6J49_RS10530	COG0571	ribonuclease III activity
I6J49_RS10535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J49_RS10540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J49_RS10560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J49_RS10575	COG0562	UDP-galactopyranose mutase
I6J49_RS10580	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS10595	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS10600	COG3475	LICD family
I6J49_RS10605	COG4750	Nucleotidyl transferase
I6J49_RS10625	COG1216	Glycosyl transferase, family 2
I6J49_RS10630	COG0562	UDP-galactopyranose mutase
I6J49_RS10635	COG1216	Glycosyl transferase, family 2
I6J49_RS10650	COG1215	transferase activity, transferring glycosyl groups
I6J49_RS10690	COG0463	Glycosyl transferase, family 2
I6J49_RS10725	COG1132	(ABC) transporter
I6J49_RS10730	COG3119	arylsulfatase activity
I6J49_RS10740	COG0463	Glycosyl transferase, family 2
I6J49_RS10750	COG0328	RNA-DNA hybrid ribonuclease activity
I6J49_RS10750	COG3341	Caulimovirus viroplasmin
I6J49_RS10760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J49_RS10770	COG0326	Molecular chaperone. Has ATPase activity
I6J49_RS10780	COG1166	arginine decarboxylase activity
I6J49_RS10785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J49_RS10810	COG0779	Required for maturation of 30S ribosomal subunits
I6J49_RS10815	COG0195	Participates in both transcription termination and antitermination
I6J49_RS10820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J49_RS10830	COG0719	Fe-S assembly protein
I6J49_RS10835	COG0396	ATPase activity
I6J49_RS10840	COG0719	Fe-S assembly protein
I6J49_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J49_RS10850	COG0393	Putative heavy-metal-binding
I6J49_RS10855	COG3119	arylsulfatase activity
I6J49_RS10865	COG1629	transport
I6J49_RS10865	COG4206	TonB-dependent receptor
I6J49_RS10875	COG1595	DNA-templated transcription, initiation
I6J49_RS10895	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J49_RS10900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J49_RS10920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J49_RS10935	COG0187	DNA topoisomerase II activity
I6J49_RS10940	COG0268	Binds directly to 16S ribosomal RNA
I6J49_RS10965	COG1381	Involved in DNA repair and RecF pathway recombination
I6J49_RS11020	COG1610	YqeY-like protein
I6J49_RS11025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J49_RS11030	COG0849	cell division
I6J49_RS11040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J49_RS11045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J49_RS11050	COG0772	Belongs to the SEDS family
I6J49_RS11055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J49_RS11060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J49_RS11065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J49_RS11080	COG0275	rRNA processing
I6J49_RS11085	COG2001	Belongs to the MraZ family
I6J49_RS11090	COG1595	DNA-templated transcription, initiation
I6J49_RS11105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J49_RS11110	COG0756	dUTP diphosphatase activity
I6J49_RS11125	COG4942	peptidase
I6J49_RS11130	COG2017	converts alpha-aldose to the beta-anomer
I6J49_RS11135	COG2818	Glycosylase
I6J49_RS11185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J49_RS11190	COG1022	Amp-dependent synthetase and ligase
I6J49_RS11205	COG2954	triphosphatase activity
I6J49_RS11275	COG0561	phosphatase activity
I6J49_RS11280	COG4771	TonB-dependent receptor
I6J49_RS11315	COG0423	glycine-tRNA ligase activity
I6J49_RS11325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J49_RS11340	COG2211	Major facilitator Superfamily
I6J49_RS11350	COG0463	Glycosyl transferase, family 2
I6J49_RS11350	COG1216	Glycosyl transferase, family 2
I6J49_RS11355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J49_RS11385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J49_RS11390	COG0589	response to stress
I6J49_RS11390	COG0475	glutathione-regulated potassium exporter activity
I6J49_RS11395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J49_RS11400	COG1136	(ABC) transporter
I6J49_RS11410	COG0733	neurotransmitter:sodium symporter activity
I6J49_RS11420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J49_RS11425	COG2205	protein histidine kinase activity
I6J49_RS11430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J49_RS11435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J49_RS11455	COG1082	Xylose isomerase domain protein TIM barrel
I6J49_RS11460	COG3507	Belongs to the glycosyl hydrolase 43 family
I6J49_RS11465	COG0745	RESPONSE REGULATOR receiver
I6J49_RS11465	COG2205	protein histidine kinase activity
I6J49_RS11465	COG3292	Two component regulator propeller
I6J49_RS11470	COG4771	TonB-dependent receptor
I6J49_RS11545	COG1346	cytolysis
I6J49_RS11550	COG1380	Effector of murein hydrolase LrgA
I6J49_RS11555	COG0280	phosphate acetyltransferase
I6J49_RS11560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J49_RS11565	COG0463	Glycosyl transferase, family 2
I6J49_RS11565	COG1216	Glycosyl transferase, family 2
I6J49_RS11570	COG2003	Belongs to the UPF0758 family
I6J49_RS11580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J49_RS11585	COG1785	Belongs to the alkaline phosphatase family
I6J49_RS11590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J49_RS11595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J49_RS11600	COG2815	serine threonine protein kinase
I6J49_RS11600	COG0515	serine threonine protein kinase
I6J49_RS11605	COG0564	pseudouridine synthase activity
I6J49_RS11635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J49_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J49_RS11645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J49_RS11655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J49_RS11670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J49_RS11675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J49_RS11685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J49_RS11685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J49_RS11690	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J49_RS11700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J49_RS11710	COG0165	Argininosuccinate lyase
I6J49_RS11765	COG0582	viral genome integration into host DNA
I6J49_RS11780	COG0768	penicillin binding
I6J49_RS11845	COG5492	domain, Protein
I6J49_RS11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J49_RS11860	COG1917	Cupin 2, conserved barrel domain protein
I6J49_RS11860	COG1396	sequence-specific DNA binding
I6J49_RS11865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J49_RS11870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J49_RS11875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J49_RS11880	COG0137	argininosuccinate synthase activity
I6J49_RS11890	COG1438	arginine binding
I6J49_RS11895	COG1070	Carbohydrate kinase
I6J49_RS11900	COG4806	L-rhamnose isomerase
I6J49_RS11910	COG0235	Class ii aldolase
I6J49_RS11915	COG1454	alcohol dehydrogenase
I6J49_RS11940	COG0564	pseudouridine synthase activity
I6J49_RS11955	COG3119	arylsulfatase activity
I6J49_RS11975	COG0612	Peptidase, M16
I6J49_RS11980	COG0534	Mate efflux family protein
I6J49_RS11985	COG0784	Response regulator, receiver
I6J49_RS11985	COG2205	protein histidine kinase activity
I6J49_RS12005	COG0488	(ABC) transporter
I6J49_RS12010	COG3590	peptidase
I6J49_RS12015	COG0138	bifunctional purine biosynthesis protein purh
I6J49_RS12040	COG0772	Belongs to the SEDS family
I6J49_RS12050	COG1774	PSP1 C-terminal conserved region
I6J49_RS12055	COG0470	DNA polymerase III
I6J49_RS12060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J49_RS12105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J49_RS12110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J49_RS12115	COG1160	GTP binding
I6J49_RS12125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J49_RS12130	COG1127	ABC transporter
I6J49_RS12135	COG0724	RNA recognition motif
I6J49_RS12140	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J49_RS12145	COG0740	serine-type endopeptidase activity
I6J49_RS12150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J49_RS12155	COG0514	ATP-dependent DNA helicase (RecQ)
I6J49_RS12160	COG0516	GMP reductase activity
I6J49_RS12160	COG0517	IMP dehydrogenase activity
I6J49_RS12165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J49_RS12175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J49_RS12190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J49_RS12230	COG3022	response to hydroperoxide
I6J49_RS12235	COG0110	maltose O-acetyltransferase activity
I6J49_RS12255	COG1187	pseudouridine synthase activity
I6J49_RS12260	COG0017	Asparaginyl-tRNA synthetase
I6J49_RS12270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J49_RS12275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J49_RS12280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J49_RS12285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J49_RS12300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J49_RS12305	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J49_RS12310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J49_RS12330	COG0482	sulfurtransferase activity
I6J49_RS12340	COG1570	exodeoxyribonuclease VII activity
I6J49_RS12350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J49_RS12360	COG0489	protein tyrosine kinase activity
I6J49_RS12365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J49_RS12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS12415	COG0039	L-malate dehydrogenase activity
I6J49_RS12430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J49_RS12435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J49_RS12440	COG0811	peptide transport
I6J49_RS12460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J49_RS12465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J49_RS12470	COG0105	UTP biosynthetic process
I6J49_RS12475	COG0739	heme binding
I6J49_RS12490	COG0149	triose-phosphate isomerase activity
I6J49_RS12500	COG0302	gtp cyclohydrolase
I6J49_RS12505	COG0358	DNA primase activity
I6J49_RS12515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J49_RS12520	COG0436	Aminotransferase
I6J49_RS12535	COG0514	ATP-dependent DNA helicase (RecQ)
I6J49_RS12540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J49_RS12540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J49_RS12550	COG0009	L-threonylcarbamoyladenylate synthase
I6J49_RS12560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J49_RS12565	COG4974	Belongs to the 'phage' integrase family
I6J49_RS12625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J49_RS12630	COG2333	competence protein COMEC
I6J49_RS12630	COG0658	competence protein
I6J49_RS12635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J49_RS12645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J49_RS12650	COG4771	TonB-dependent receptor
I6J49_RS12665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6J49_RS12670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J49_RS12680	COG0527	aspartate kinase activity
I6J49_RS12680	COG0460	homoserine dehydrogenase
I6J49_RS12685	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
I6J49_RS12725	COG1522	sequence-specific DNA binding
I6J49_RS12740	COG0251	oxidation-reduction process
I6J49_RS12750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J49_RS12755	COG1333	cytochrome c biogenesis protein
I6J49_RS12755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J49_RS12765	COG0110	maltose O-acetyltransferase activity
I6J49_RS12770	COG0386	Belongs to the glutathione peroxidase family
I6J49_RS12775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J49_RS12780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J49_RS12835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J49_RS12850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J49_RS12855	COG0742	ribosomal rna small subunit methyltransferase
I6J49_RS12870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J49_RS12880	COG4771	TonB-dependent receptor
I6J49_RS12890	COG3537	Alpha-1,2-mannosidase
I6J49_RS12895	COG3537	Alpha-1,2-mannosidase
I6J49_RS12915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J49_RS12920	COG0739	heme binding
I6J49_RS12930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J49_RS12935	COG1388	LysM domain
I6J49_RS12935	COG0741	lytic transglycosylase activity
I6J49_RS12945	COG1475	DNA binding
I6J49_RS12950	COG1192	Involved in chromosome partitioning
I6J49_RS12955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J49_RS12960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J49_RS12975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J49_RS12990	COG1196	nuclear chromosome segregation
I6J49_RS12995	COG2239	Acts as a magnesium transporter
I6J49_RS13000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J49_RS13010	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J49_RS13030	COG3250	beta-galactosidase activity
I6J49_RS13055	COG0668	transmembrane transport
I6J49_RS13060	COG0662	Cupin 2, conserved barrel domain protein
I6J49_RS13060	COG2207	Transcriptional regulator
I6J49_RS13075	COG2205	protein histidine kinase activity
I6J49_RS13075	COG0784	Response regulator, receiver
I6J49_RS13090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J49_RS13095	COG0713	ATP synthesis coupled electron transport
I6J49_RS13110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J49_RS13115	COG0649	NAD binding
I6J49_RS13115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J49_RS13120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J49_RS13125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J49_RS13135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J49_RS13140	COG0569	domain protein
I6J49_RS13145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J49_RS13155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J49_RS13160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J49_RS13165	COG0805	protein transport
I6J49_RS13175	COG2271	Major facilitator Superfamily
I6J49_RS13180	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6J49_RS13185	COG3775	system Galactitol-specific IIC component
I6J49_RS13190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS13200	COG2755	lipolytic protein G-D-S-L family
I6J49_RS13205	COG2205	protein histidine kinase activity
I6J49_RS13205	COG0745	RESPONSE REGULATOR receiver
I6J49_RS13205	COG3292	Two component regulator propeller
I6J49_RS13215	COG0702	epimerase
I6J49_RS13220	COG4771	TonB-dependent receptor
I6J49_RS13240	COG3279	Response regulator of the LytR AlgR family
I6J49_RS13245	COG1242	4 iron, 4 sulfur cluster binding
I6J49_RS13255	COG0363	glucosamine-6-phosphate deaminase activity
I6J49_RS13265	COG0009	L-threonylcarbamoyladenylate synthase
I6J49_RS13275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J49_RS13280	COG0561	phosphatase activity
I6J49_RS13300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J49_RS13315	COG4206	TonB-dependent receptor
I6J49_RS13315	COG1629	transport
I6J49_RS13335	COG3507	Belongs to the glycosyl hydrolase 43 family
I6J49_RS13350	COG3250	beta-galactosidase activity
I6J49_RS13365	COG0546	phosphoglycolate phosphatase activity
I6J49_RS13385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J49_RS13395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J49_RS13405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J49_RS13445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J49_RS13460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J49_RS13460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6J49_RS13465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J49_RS13470	COG1078	dGTPase activity
I6J49_RS13475	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J49_RS13480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J49_RS13490	COG1704	LemA family
I6J49_RS13505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J49_RS13510	COG2226	methyltransferase
I6J49_RS13515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J49_RS13520	COG1702	phosphate starvation-inducible protein PhoH
I6J49_RS13535	COG2268	Band 7 protein
I6J49_RS13580	COG2205	protein histidine kinase activity
I6J49_RS13580	COG3292	Two component regulator propeller
I6J49_RS13580	COG0745	RESPONSE REGULATOR receiver
I6J49_RS13585	COG0101	tRNA pseudouridine synthase activity
I6J49_RS13605	COG3250	beta-galactosidase activity
I6J49_RS13610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J49_RS13615	COG0673	inositol 2-dehydrogenase activity
I6J49_RS13640	COG1629	transport
I6J49_RS13655	COG4771	TonB-dependent receptor
I6J49_RS13660	COG0702	epimerase
I6J49_RS13680	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J49_RS13695	COG1629	transport
I6J49_RS13700	COG0561	phosphatase activity
I6J49_RS13720	COG0673	inositol 2-dehydrogenase activity
I6J49_RS13735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J49_RS13745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J49_RS13760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J49_RS13765	COG0793	Belongs to the peptidase S41A family
I6J49_RS13770	COG2131	deaminase
I6J49_RS13780	COG0339	signal peptide processing
I6J49_RS13790	COG1970	mechanosensitive ion channel activity
I6J49_RS13810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J49_RS13810	COG0519	Catalyzes the synthesis of GMP from XMP
I6J49_RS13825	COG4771	TonB-dependent receptor
I6J49_RS13830	COG0561	phosphatase activity
I6J49_RS13835	COG1629	transport
I6J49_RS13865	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS13880	COG0297	glycogen (starch) synthase activity
I6J49_RS13885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J49_RS13890	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J49_RS13895	COG0543	2 iron, 2 sulfur cluster binding
I6J49_RS13905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J49_RS13915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J49_RS13920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J49_RS13935	COG0791	NLP P60 protein
I6J49_RS13950	COG0612	Peptidase, M16
I6J49_RS13955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J49_RS13960	COG1597	lipid kinase activity
I6J49_RS13965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J49_RS13975	COG0702	epimerase
I6J49_RS13980	COG4771	TonB-dependent receptor
I6J49_RS13995	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS14000	COG2205	protein histidine kinase activity
I6J49_RS14000	COG3292	Two component regulator propeller
I6J49_RS14000	COG0745	RESPONSE REGULATOR receiver
I6J49_RS14015	COG1136	(ABC) transporter
I6J49_RS14035	COG2211	Major facilitator Superfamily
I6J49_RS14040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J49_RS14055	COG1674	ftsk spoiiie
I6J49_RS14065	COG0492	ferredoxin-NADP+ reductase activity
I6J49_RS14070	COG3118	belongs to the thioredoxin family
I6J49_RS14080	COG1404	Belongs to the peptidase S8 family
I6J49_RS14100	COG4206	TonB-dependent receptor
I6J49_RS14100	COG1629	transport
I6J49_RS14135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J49_RS14135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J49_RS14140	COG0539	negative regulation of cytoplasmic translation
I6J49_RS14145	COG1234	tRNA 3'-trailer cleavage
I6J49_RS14150	COG2989	Protein conserved in bacteria
I6J49_RS14170	COG3956	TIGRFAM MazG family protein
I6J49_RS14185	COG0525	valine-tRNA ligase activity
I6J49_RS14190	COG0784	Response regulator, receiver
I6J49_RS14190	COG2205	protein histidine kinase activity
I6J49_RS14205	COG1629	transport
I6J49_RS14250	COG0653	protein targeting
I6J49_RS14255	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
I6J49_RS14265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J49_RS14285	COG1253	flavin adenine dinucleotide binding
I6J49_RS14290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J49_RS14295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J49_RS14305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J49_RS14350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J49_RS14350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J49_RS14360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J49_RS14365	COG0563	adenylate kinase activity
I6J49_RS14370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J49_RS14375	COG1496	oxidoreductase activity
I6J49_RS14395	COG4206	TonB-dependent receptor
I6J49_RS14395	COG1629	transport
I6J49_RS14400	COG0561	phosphatase activity
I6J49_RS14405	COG3119	arylsulfatase activity
I6J49_RS14420	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS14435	COG2814	Major facilitator Superfamily
I6J49_RS14440	COG0457	Tetratricopeptide repeat
I6J49_RS14445	COG2706	6-phosphogluconolactonase activity
I6J49_RS14450	COG4771	TonB-dependent receptor
I6J49_RS14455	COG0702	epimerase
I6J49_RS14460	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J49_RS14470	COG0745	RESPONSE REGULATOR receiver
I6J49_RS14470	COG3292	Two component regulator propeller
I6J49_RS14470	COG2205	protein histidine kinase activity
I6J49_RS14470	COG0745	RESPONSE REGULATOR receiver
I6J49_RS14470	COG3292	Two component regulator propeller
I6J49_RS14470	COG2205	protein histidine kinase activity
I6J49_RS14475	COG1629	transport
I6J49_RS14575	COG3142	Participates in the control of copper homeostasis
I6J49_RS14580	COG1418	mRNA catabolic process
I6J49_RS14595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J49_RS14600	COG2832	Protein of unknown function (DUF454)
I6J49_RS14610	COG0602	queuosine metabolic process
I6J49_RS14615	COG0247	lactate metabolic process
I6J49_RS14620	COG1139	Iron-sulfur cluster binding protein
I6J49_RS14630	COG0351	phosphomethylpyrimidine kinase
I6J49_RS14635	COG4771	TonB-dependent receptor
I6J49_RS14645	COG2304	oxidoreductase activity
I6J49_RS14655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS14665	COG1393	Belongs to the ArsC family
I6J49_RS14675	COG4771	TonB-dependent receptor
I6J49_RS14690	COG2233	PERMEase
I6J49_RS14695	COG1509	lysine 2,3-aminomutase activity
I6J49_RS14730	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS14740	COG0776	regulation of translation
I6J49_RS14745	COG0305	Participates in initiation and elongation during chromosome replication
I6J49_RS14775	COG3250	beta-galactosidase activity
I6J49_RS14780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J49_RS14790	COG0741	lytic transglycosylase activity
I6J49_RS14790	COG1388	LysM domain
I6J49_RS14810	COG2205	protein histidine kinase activity
I6J49_RS14810	COG0784	Response regulator, receiver
I6J49_RS14835	COG0534	Mate efflux family protein
I6J49_RS14845	COG0564	pseudouridine synthase activity
I6J49_RS14875	COG0346	lactoylglutathione lyase activity
I6J49_RS14890	COG1401	restriction endodeoxyribonuclease activity
I6J49_RS14895	COG4268	DNA restriction-modification system
I6J49_RS14915	COG0432	Pfam Uncharacterised protein family UPF0047
I6J49_RS14930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J49_RS14945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J49_RS14965	COG5290	Psort location Cytoplasmic, score
I6J49_RS15000	COG4974	Belongs to the 'phage' integrase family
I6J49_RS15010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J49_RS15020	COG2204	response regulator
I6J49_RS15025	COG2910	NAD(P)H-binding
I6J49_RS15035	COG4864	UPF0365 protein
I6J49_RS15050	COG0037	tRNA processing
I6J49_RS15060	COG1477	protein flavinylation
I6J49_RS15065	COG1971	Probably functions as a manganese efflux pump
I6J49_RS15080	COG0463	Glycosyl transferase, family 2
I6J49_RS15105	COG1595	DNA-templated transcription, initiation
I6J49_RS15110	COG0148	phosphopyruvate hydratase activity
I6J49_RS15120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J49_RS15125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J49_RS15130	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J49_RS15135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J49_RS15140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J49_RS15140	COG4651	solute:proton antiporter activity
I6J49_RS15150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J49_RS15155	COG0193	aminoacyl-tRNA hydrolase activity
I6J49_RS15160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J49_RS15170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J49_RS15175	COG1862	Preprotein translocase
I6J49_RS15185	COG0237	dephospho-CoA kinase activity
I6J49_RS15195	COG0542	response to heat
I6J49_RS15205	COG0583	DNA-binding transcription factor activity
I6J49_RS15210	COG3304	Inner membrane component domain
I6J49_RS15215	COG2855	membrane
I6J49_RS15235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J49_RS15240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J49_RS15270	COG0443	Heat shock 70 kDa protein
I6J49_RS15275	COG0306	phosphate transporter
I6J49_RS15285	COG0586	Pfam SNARE associated Golgi protein
I6J49_RS15320	COG0038	chloride channel
I6J49_RS15325	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J49_RS15330	COG2172	sigma factor antagonist activity
I6J49_RS15355	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J49_RS15360	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I6J49_RS15365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J49_RS15380	COG3250	beta-galactosidase activity
I6J49_RS15395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J49_RS15400	COG1629	transport
I6J49_RS15400	COG4206	TonB-dependent receptor
I6J49_RS15410	COG0745	RESPONSE REGULATOR receiver
I6J49_RS15410	COG2205	protein histidine kinase activity
I6J49_RS15410	COG3292	Two component regulator propeller
I6J49_RS15430	COG1760	l-serine dehydratase
I6J49_RS15435	COG0598	Magnesium transport protein CorA
I6J49_RS15440	COG1193	negative regulation of DNA recombination
I6J49_RS15485	COG0358	DNA primase activity
I6J49_RS15515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J49_RS15535	COG1629	transport
I6J49_RS15540	COG3292	Two component regulator propeller
I6J49_RS15540	COG2205	protein histidine kinase activity
I6J49_RS15540	COG0745	RESPONSE REGULATOR receiver
I6J49_RS15540	COG3292	Two component regulator propeller
I6J49_RS15540	COG0745	RESPONSE REGULATOR receiver
I6J49_RS15540	COG2205	protein histidine kinase activity
I6J49_RS15570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6J49_RS15575	COG5002	protein histidine kinase activity
I6J49_RS15585	COG3189	MarR family transcriptional regulator
I6J49_RS15590	COG0561	phosphatase activity
I6J49_RS15595	COG1169	isochorismate synthase
I6J49_RS15600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J49_RS15605	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J49_RS15610	COG4948	Mandelate Racemase Muconate Lactonizing
I6J49_RS15620	COG0783	Belongs to the Dps family
I6J49_RS15625	COG0583	DNA-binding transcription factor activity
I6J49_RS15635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J49_RS15655	COG3458	cephalosporin-C deacetylase activity
I6J49_RS15660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J49_RS15665	COG1882	Formate acetyltransferase
I6J49_RS15705	COG4804	nuclease activity
I6J49_RS15750	COG1253	flavin adenine dinucleotide binding
I6J49_RS15755	COG0501	Belongs to the peptidase M48B family
I6J49_RS15780	COG0482	sulfurtransferase activity
I6J49_RS15785	COG2197	response regulator
I6J49_RS15795	COG1757	Na H antiporter
I6J49_RS15805	COG2814	Major facilitator Superfamily
I6J49_RS15810	COG4953	penicillin-binding protein 1C
I6J49_RS15815	COG2373	Large extracellular alpha-helical protein
I6J49_RS15820	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J49_RS15865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J49_RS15870	COG1410	methionine synthase
I6J49_RS15870	COG0646	methionine synthase
I6J49_RS15875	COG0778	Nitroreductase
I6J49_RS15885	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J49_RS15890	COG0572	uridine kinase
I6J49_RS15900	COG4232	protein-disulfide reductase activity
I6J49_RS15905	COG0738	Major facilitator superfamily
I6J49_RS15915	COG1070	Carbohydrate kinase
I6J49_RS15925	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
I6J49_RS15930	COG2188	Transcriptional regulator
I6J49_RS15935	COG0228	four-way junction DNA binding
I6J49_RS15960	COG3275	phosphorelay sensor kinase activity
I6J49_RS15970	COG2205	protein histidine kinase activity
I6J49_RS15970	COG0784	Response regulator, receiver
I6J49_RS15975	COG5002	protein histidine kinase activity
I6J49_RS15985	COG1733	regulation of RNA biosynthetic process
I6J49_RS16010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J49_RS16015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J49_RS16020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J49_RS16025	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J49_RS16045	COG1592	Rubrerythrin
I6J49_RS16045	COG1773	rubredoxin
I6J49_RS16060	COG0702	epimerase
I6J49_RS16065	COG4771	TonB-dependent receptor
I6J49_RS16090	COG3118	belongs to the thioredoxin family
I6J49_RS16105	COG3591	Belongs to the peptidase S1B family
I6J49_RS16110	COG3591	Belongs to the peptidase S1B family
I6J49_RS16115	COG0641	radical SAM
I6J49_RS16130	COG0420	3'-5' exonuclease activity
I6J49_RS16140	COG1408	metallophosphoesterase
I6J49_RS16155	COG0646	methionine synthase
I6J49_RS16155	COG1410	methionine synthase
I6J49_RS16165	COG0463	Glycosyl transferase, family 2
I6J49_RS16170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J49_RS16175	COG1032	radical SAM domain protein
I6J49_RS16195	COG0363	glucosamine-6-phosphate deaminase activity
I6J49_RS16200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J49_RS16215	COG4974	Belongs to the 'phage' integrase family
I6J49_RS16235	COG1131	(ABC) transporter
I6J49_RS16270	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J49_RS16295	COG3757	hydrolase, family 25
I6J49_RS16310	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J49_RS16315	COG0022	dehydrogenase e1 component
I6J49_RS16325	COG2264	protein methyltransferase activity
I6J49_RS16345	COG0590	tRNA wobble adenosine to inosine editing
I6J49_RS16350	COG0673	inositol 2-dehydrogenase activity
I6J49_RS16355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J49_RS16395	COG0698	ribose 5-phosphate isomerase
I6J49_RS16415	COG2160	L-arabinose isomerase activity
I6J49_RS16445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J49_RS16460	COG1482	cell wall glycoprotein biosynthetic process
I6J49_RS16480	COG4221	oxidoreductase activity
I6J49_RS16490	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6J49_RS16495	COG0471	metal ion transport
I6J49_RS16495	COG3273	potassium ion transport
I6J49_RS16500	COG0529	Catalyzes the synthesis of activated sulfate
I6J49_RS16505	COG0175	sulfate reduction
I6J49_RS16510	COG2895	sulfate adenylyltransferase (ATP) activity
I6J49_RS16530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J49_RS16535	COG0242	peptide deformylase activity
I6J49_RS16545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J49_RS16550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J49_RS16555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J49_RS16560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J49_RS16570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J49_RS16575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J49_RS16580	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J49_RS16580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J49_RS16580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J49_RS16580	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J49_RS16590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J49_RS16615	COG2197	response regulator
I6J49_RS16810	COG0863	Belongs to the N(4) N(6)-methyltransferase family
I6J49_RS17205	COG1940	carbohydrate kinase activity
I6J49_RS17210	COG2731	YhcH YjgK YiaL family protein
I6J49_RS17215	COG2271	Major facilitator Superfamily
I6J49_RS17220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J49_RS17230	COG4771	TonB-dependent receptor
I6J49_RS17235	COG0702	epimerase
I6J49_RS17245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS17265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS17270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J49_RS17275	COG4771	TonB-dependent receptor
I6J49_RS17280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J49_RS17285	COG0484	heat shock protein binding
I6J49_RS17290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J49_RS17295	COG0488	(ABC) transporter
I6J49_RS17310	COG2183	response to ionizing radiation
I6J49_RS17315	COG2205	protein histidine kinase activity
I6J49_RS17315	COG2202	Pas domain
I6J49_RS17320	COG0737	Belongs to the 5'-nucleotidase family
I6J49_RS17360	COG2985	domain, Protein
I6J49_RS17360	COG0490	domain, Protein
I6J49_RS17365	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J49_RS17375	COG0318	PFAM AMP-dependent synthetase and ligase
I6J49_RS17380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J49_RS17385	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J49_RS17390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J49_RS17395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J49_RS17400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J49_RS17405	COG0363	glucosamine-6-phosphate deaminase activity
I6J49_RS17420	COG3279	Response regulator of the LytR AlgR family
I6J49_RS17430	COG1136	(ABC) transporter
I6J49_RS17430	COG0577	efflux transmembrane transporter activity
I6J49_RS17435	COG1136	(ABC) transporter
I6J49_RS17440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J49_RS17465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J49_RS17470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J49_RS17500	COG1704	LemA family
I6J49_RS17510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J49_RS17515	COG2885	chlorophyll binding
I6J49_RS17520	COG0534	Mate efflux family protein
I6J49_RS17530	COG2205	protein histidine kinase activity
I6J49_RS17530	COG0784	Response regulator, receiver
I6J49_RS17545	COG0488	(ABC) transporter
I6J49_RS17560	COG2205	protein histidine kinase activity
I6J49_RS17560	COG0784	Response regulator, receiver
I6J49_RS17590	COG2244	polysaccharide biosynthetic process
I6J49_RS17595	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS17615	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J49_RS17660	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J49_RS17665	COG1805	sodium ion transport
I6J49_RS17670	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J49_RS17685	COG2871	sodium ion transport
I6J49_RS17695	COG0513	Belongs to the DEAD box helicase family
I6J49_RS17700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J49_RS17705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J49_RS17715	COG1739	Uncharacterized protein family UPF0029
I6J49_RS17730	COG0778	Nitroreductase
I6J49_RS17735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J49_RS17735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J49_RS17740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J49_RS17745	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J49_RS17760	COG1629	transport
I6J49_RS17760	COG4206	TonB-dependent receptor
I6J49_RS17770	COG2217	Heavy metal translocating P-type atpase
I6J49_RS17780	COG0321	lipoyl(octanoyl) transferase activity
I6J49_RS17810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J49_RS17820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J49_RS17835	COG1678	Uncharacterized ACR, COG1678
I6J49_RS17850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J49_RS17855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J49_RS17855	COG0662	Cupin 2, conserved barrel domain protein
I6J49_RS17875	COG1131	(ABC) transporter
I6J49_RS17880	COG0842	Transport permease protein
I6J49_RS17885	COG0842	Transport permease protein
I6J49_RS17890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J49_RS17895	COG2949	membrane
I6J49_RS17900	COG0556	nucleotide-excision repair
I6J49_RS17905	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J49_RS17935	COG1388	LysM domain
I6J49_RS17935	COG3942	CHAP domain
I6J49_RS17945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J49_RS17960	COG1695	Transcriptional regulator
I6J49_RS17980	COG0823	Involved in the tonB-independent uptake of proteins
I6J49_RS17980	COG1506	peptidase
I6J49_RS17985	COG0534	Mate efflux family protein
I6J49_RS17990	COG0706	membrane insertase activity
I6J49_RS17995	COG0504	CTP synthase activity
I6J49_RS18085	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS18105	COG1442	glycosyl transferase family 8
I6J49_RS18105	COG1216	Glycosyl transferase, family 2
I6J49_RS18115	COG0438	transferase activity, transferring glycosyl groups
I6J49_RS18125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J49_RS18175	COG4656	Part of a membrane complex involved in electron transport
I6J49_RS18180	COG4658	electron transport chain
I6J49_RS18185	COG4659	FMN binding
I6J49_RS18190	COG4660	Part of a membrane complex involved in electron transport
I6J49_RS18195	COG4657	Part of a membrane complex involved in electron transport
I6J49_RS18200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J49_RS18205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J49_RS18210	COG0305	Participates in initiation and elongation during chromosome replication
I6J49_RS18215	COG0072	phenylalanine-tRNA ligase activity
I6J49_RS18215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J49_RS18220	COG0217	transcriptional regulatory protein
I6J49_RS18235	COG0708	Exodeoxyribonuclease III
I6J49_RS18250	COG0481	GTPase activity
I6J49_RS18275	COG0024	Methionine aminopeptidase
I6J49_RS18295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J49_RS18300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J49_RS18300	COG0574	Belongs to the PEP-utilizing enzyme family
I6J49_RS18320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J49_RS18330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J49_RS18335	COG2022	thiamine diphosphate biosynthetic process
I6J49_RS18340	COG0352	thiamine-phosphate diphosphorylase activity
I6J49_RS18350	COG4999	Histidine kinase
I6J49_RS18350	COG3850	Histidine kinase
I6J49_RS18350	COG3437	response regulator, receiver
I6J49_RS18350	COG2205	protein histidine kinase activity