locus-tag	class	description
A4V03_RS00005	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00015	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00035	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS00040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V03_RS00060	COG3345	alpha-galactosidase
A4V03_RS00090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS00105	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00115	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00125	COG0702	epimerase
A4V03_RS00130	COG4771	TonB-dependent receptor
A4V03_RS00140	COG2814	Major facilitator Superfamily
A4V03_RS00155	COG1609	Transcriptional regulator
A4V03_RS00155	COG2207	Transcriptional regulator
A4V03_RS00160	COG0423	glycine-tRNA ligase activity
A4V03_RS00170	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00180	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS00185	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00200	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00205	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00210	COG4771	TonB-dependent receptor
A4V03_RS00220	COG1629	transport
A4V03_RS00220	COG4206	TonB-dependent receptor
A4V03_RS00225	COG0702	epimerase
A4V03_RS00245	COG2382	esterase
A4V03_RS00255	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00255	COG2205	protein histidine kinase activity
A4V03_RS00255	COG3292	Two component regulator propeller
A4V03_RS00265	COG2382	esterase
A4V03_RS00265	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00265	COG3693	PFAM glycoside hydrolase, family 10
A4V03_RS00290	COG2211	Major facilitator Superfamily
A4V03_RS00360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4V03_RS00375	COG0589	response to stress
A4V03_RS00375	COG0475	glutathione-regulated potassium exporter activity
A4V03_RS00380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V03_RS00385	COG1136	(ABC) transporter
A4V03_RS00395	COG0733	neurotransmitter:sodium symporter activity
A4V03_RS00405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V03_RS00410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V03_RS00415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4V03_RS00435	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS00450	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00450	COG2205	protein histidine kinase activity
A4V03_RS00450	COG3292	Two component regulator propeller
A4V03_RS00455	COG4771	TonB-dependent receptor
A4V03_RS00465	COG1629	transport
A4V03_RS00465	COG4206	TonB-dependent receptor
A4V03_RS00500	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS00515	COG1346	cytolysis
A4V03_RS00520	COG1380	Effector of murein hydrolase LrgA
A4V03_RS00525	COG0280	phosphate acetyltransferase
A4V03_RS00530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4V03_RS00535	COG1349	DNA-binding transcription factor activity
A4V03_RS00540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4V03_RS00550	COG0371	Dehydrogenase
A4V03_RS00555	COG2271	Major facilitator Superfamily
A4V03_RS00560	COG0546	phosphoglycolate phosphatase activity
A4V03_RS00565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS00590	COG1629	transport
A4V03_RS00610	COG0463	Glycosyl transferase, family 2
A4V03_RS00610	COG1216	Glycosyl transferase, family 2
A4V03_RS00615	COG2003	Belongs to the UPF0758 family
A4V03_RS00635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4V03_RS00655	COG1785	Belongs to the alkaline phosphatase family
A4V03_RS00660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4V03_RS00665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V03_RS00670	COG0515	serine threonine protein kinase
A4V03_RS00670	COG2815	serine threonine protein kinase
A4V03_RS00675	COG0564	pseudouridine synthase activity
A4V03_RS00700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V03_RS00705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V03_RS00710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4V03_RS00720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V03_RS00735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4V03_RS00740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4V03_RS00750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V03_RS00750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V03_RS00755	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V03_RS00765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V03_RS00775	COG0165	Argininosuccinate lyase
A4V03_RS00805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4V03_RS00810	COG1917	Cupin 2, conserved barrel domain protein
A4V03_RS00810	COG1396	sequence-specific DNA binding
A4V03_RS00815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V03_RS00820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V03_RS00825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V03_RS00830	COG0137	argininosuccinate synthase activity
A4V03_RS00840	COG1438	arginine binding
A4V03_RS00850	COG1070	Carbohydrate kinase
A4V03_RS00855	COG4806	L-rhamnose isomerase
A4V03_RS00865	COG0235	Class ii aldolase
A4V03_RS00870	COG1454	alcohol dehydrogenase
A4V03_RS00895	COG0564	pseudouridine synthase activity
A4V03_RS00925	COG3537	Alpha-1,2-mannosidase
A4V03_RS00935	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00935	COG2205	protein histidine kinase activity
A4V03_RS00935	COG3292	Two component regulator propeller
A4V03_RS00945	COG4206	TonB-dependent receptor
A4V03_RS00945	COG1629	transport
A4V03_RS00950	COG0702	epimerase
A4V03_RS00980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V03_RS00980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V03_RS00985	COG0612	Peptidase, M16
A4V03_RS00990	COG0534	Mate efflux family protein
A4V03_RS00995	COG2205	protein histidine kinase activity
A4V03_RS00995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS01020	COG1629	transport
A4V03_RS01050	COG0488	(ABC) transporter
A4V03_RS01055	COG3590	peptidase
A4V03_RS01060	COG0138	bifunctional purine biosynthesis protein purh
A4V03_RS01085	COG0772	Belongs to the SEDS family
A4V03_RS01095	COG1774	PSP1 C-terminal conserved region
A4V03_RS01100	COG0470	DNA polymerase III
A4V03_RS01105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V03_RS01155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V03_RS01160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V03_RS01165	COG1160	GTP binding
A4V03_RS01175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4V03_RS01180	COG1127	ABC transporter
A4V03_RS01185	COG0724	RNA recognition motif
A4V03_RS01190	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V03_RS01195	COG0740	serine-type endopeptidase activity
A4V03_RS01200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V03_RS01205	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS01210	COG0516	GMP reductase activity
A4V03_RS01210	COG0517	IMP dehydrogenase activity
A4V03_RS01225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4V03_RS01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4V03_RS01245	COG2885	chlorophyll binding
A4V03_RS01260	COG4206	TonB-dependent receptor
A4V03_RS01260	COG1629	transport
A4V03_RS01295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01310	COG0612	Peptidase, M16
A4V03_RS01330	COG3022	response to hydroperoxide
A4V03_RS01355	COG1187	pseudouridine synthase activity
A4V03_RS01360	COG0017	Asparaginyl-tRNA synthetase
A4V03_RS01380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4V03_RS01385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4V03_RS01390	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V03_RS01395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V03_RS01405	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4V03_RS01410	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V03_RS01415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V03_RS01430	COG0482	sulfurtransferase activity
A4V03_RS01440	COG1570	exodeoxyribonuclease VII activity
A4V03_RS01450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V03_RS01460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V03_RS01465	COG0489	protein tyrosine kinase activity
A4V03_RS01475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4V03_RS01500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS01520	COG0714	Associated with various cellular activities
A4V03_RS01525	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4V03_RS01530	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4V03_RS01535	COG0039	L-malate dehydrogenase activity
A4V03_RS01545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V03_RS01550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4V03_RS01555	COG0811	peptide transport
A4V03_RS01560	COG0848	biopolymer transport protein
A4V03_RS01575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V03_RS01580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V03_RS01590	COG0739	heme binding
A4V03_RS01605	COG0149	triose-phosphate isomerase activity
A4V03_RS01615	COG0302	gtp cyclohydrolase
A4V03_RS01620	COG0358	DNA primase activity
A4V03_RS01630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V03_RS01650	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS01655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V03_RS01655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4V03_RS01665	COG0009	L-threonylcarbamoyladenylate synthase
A4V03_RS01675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4V03_RS01680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V03_RS01685	COG2333	competence protein COMEC
A4V03_RS01685	COG0658	competence protein
A4V03_RS01690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4V03_RS01700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V03_RS01710	COG4771	TonB-dependent receptor
A4V03_RS01720	COG3537	Alpha-1,2-mannosidase
A4V03_RS01725	COG3537	Alpha-1,2-mannosidase
A4V03_RS01735	COG3537	Alpha-1,2-mannosidase
A4V03_RS01745	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS01755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V03_RS01795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V03_RS01810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V03_RS01815	COG0742	ribosomal rna small subunit methyltransferase
A4V03_RS01830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS01865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V03_RS01870	COG5433	transposase activity
A4V03_RS01885	COG0739	heme binding
A4V03_RS01895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V03_RS01900	COG1388	LysM domain
A4V03_RS01900	COG0741	lytic transglycosylase activity
A4V03_RS01910	COG1475	DNA binding
A4V03_RS01915	COG1192	Involved in chromosome partitioning
A4V03_RS01920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4V03_RS01925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS01955	COG1196	nuclear chromosome segregation
A4V03_RS01960	COG2239	Acts as a magnesium transporter
A4V03_RS01965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V03_RS01975	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS02015	COG0668	transmembrane transport
A4V03_RS02030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4V03_RS02035	COG0713	ATP synthesis coupled electron transport
A4V03_RS02050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4V03_RS02055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02055	COG0649	NAD binding
A4V03_RS02060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V03_RS02080	COG0569	domain protein
A4V03_RS02085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V03_RS02100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V03_RS02105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4V03_RS02110	COG0805	protein transport
A4V03_RS02120	COG2271	Major facilitator Superfamily
A4V03_RS02125	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V03_RS02130	COG3775	system Galactitol-specific IIC component
A4V03_RS02145	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02155	COG2205	protein histidine kinase activity
A4V03_RS02155	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02155	COG3292	Two component regulator propeller
A4V03_RS02165	COG0702	epimerase
A4V03_RS02170	COG4771	TonB-dependent receptor
A4V03_RS02190	COG3279	Response regulator of the LytR AlgR family
A4V03_RS02195	COG1242	4 iron, 4 sulfur cluster binding
A4V03_RS02205	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS02210	COG0009	L-threonylcarbamoyladenylate synthase
A4V03_RS02220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS02225	COG0561	phosphatase activity
A4V03_RS02230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V03_RS02265	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02285	COG1874	Beta-galactosidase
A4V03_RS02290	COG0702	epimerase
A4V03_RS02295	COG1629	transport
A4V03_RS02315	COG4771	TonB-dependent receptor
A4V03_RS02325	COG1629	transport
A4V03_RS02335	COG3401	FG-GAP repeat protein
A4V03_RS02345	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02355	COG3401	FG-GAP repeat protein
A4V03_RS02365	COG3254	rhamnose metabolic process
A4V03_RS02370	COG2205	protein histidine kinase activity
A4V03_RS02370	COG3292	Two component regulator propeller
A4V03_RS02370	COG2205	protein histidine kinase activity
A4V03_RS02370	COG3292	Two component regulator propeller
A4V03_RS02370	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02370	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02375	COG3401	FG-GAP repeat protein
A4V03_RS02455	COG4974	Belongs to the 'phage' integrase family
A4V03_RS02500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4V03_RS02520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4V03_RS02525	COG1506	peptidase
A4V03_RS02525	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS02530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V03_RS02545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4V03_RS02545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V03_RS02550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS02555	COG1078	dGTPase activity
A4V03_RS02560	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V03_RS02565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V03_RS02575	COG1704	LemA family
A4V03_RS02590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V03_RS02595	COG2226	methyltransferase
A4V03_RS02600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V03_RS02605	COG1702	phosphate starvation-inducible protein PhoH
A4V03_RS02630	COG2268	Band 7 protein
A4V03_RS02640	COG0101	tRNA pseudouridine synthase activity
A4V03_RS02660	COG3250	beta-galactosidase activity
A4V03_RS02665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V03_RS02670	COG0673	inositol 2-dehydrogenase activity
A4V03_RS02685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4V03_RS02695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS02705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4V03_RS02710	COG0793	Belongs to the peptidase S41A family
A4V03_RS02715	COG2131	deaminase
A4V03_RS02725	COG0339	signal peptide processing
A4V03_RS02735	COG1970	mechanosensitive ion channel activity
A4V03_RS02745	COG1376	ErfK ybiS ycfS ynhG family protein
A4V03_RS02755	COG0443	Heat shock 70 kDa protein
A4V03_RS02770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4V03_RS02770	COG0519	Catalyzes the synthesis of GMP from XMP
A4V03_RS02800	COG4206	TonB-dependent receptor
A4V03_RS02800	COG1629	transport
A4V03_RS02825	COG0793	Belongs to the peptidase S41A family
A4V03_RS02830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS02845	COG0297	glycogen (starch) synthase activity
A4V03_RS02860	COG0297	glycogen (starch) synthase activity
A4V03_RS02865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4V03_RS02870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4V03_RS02875	COG0543	2 iron, 2 sulfur cluster binding
A4V03_RS02880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V03_RS02885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V03_RS02890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4V03_RS02895	COG0791	NLP P60 protein
A4V03_RS02910	COG0612	Peptidase, M16
A4V03_RS02915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4V03_RS02920	COG1597	lipid kinase activity
A4V03_RS02925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V03_RS02940	COG1136	(ABC) transporter
A4V03_RS02960	COG2211	Major facilitator Superfamily
A4V03_RS02965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V03_RS02980	COG1674	ftsk spoiiie
A4V03_RS02990	COG0492	ferredoxin-NADP+ reductase activity
A4V03_RS03030	COG4206	TonB-dependent receptor
A4V03_RS03030	COG1629	transport
A4V03_RS03065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4V03_RS03065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4V03_RS03075	COG1234	tRNA 3'-trailer cleavage
A4V03_RS03080	COG2989	Protein conserved in bacteria
A4V03_RS03100	COG3956	TIGRFAM MazG family protein
A4V03_RS03115	COG0525	valine-tRNA ligase activity
A4V03_RS03130	COG0653	protein targeting
A4V03_RS03135	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A4V03_RS03145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V03_RS03165	COG1253	flavin adenine dinucleotide binding
A4V03_RS03175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V03_RS03185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4V03_RS03190	COG2204	response regulator
A4V03_RS03230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V03_RS03230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V03_RS03235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4V03_RS03240	COG0563	adenylate kinase activity
A4V03_RS03245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V03_RS03260	COG0739	heme binding
A4V03_RS03305	COG3142	Participates in the control of copper homeostasis
A4V03_RS03310	COG1418	mRNA catabolic process
A4V03_RS03340	COG1070	Carbohydrate kinase
A4V03_RS03345	COG1063	alcohol dehydrogenase
A4V03_RS03350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4V03_RS03375	COG1333	cytochrome c biogenesis protein
A4V03_RS03375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V03_RS03390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V03_RS03395	COG2832	Protein of unknown function (DUF454)
A4V03_RS03405	COG0602	queuosine metabolic process
A4V03_RS03410	COG0247	lactate metabolic process
A4V03_RS03420	COG0351	phosphomethylpyrimidine kinase
A4V03_RS03435	COG2304	oxidoreductase activity
A4V03_RS03445	COG1393	Belongs to the ArsC family
A4V03_RS03485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V03_RS03490	COG1388	LysM domain
A4V03_RS03490	COG0741	lytic transglycosylase activity
A4V03_RS03570	COG0358	DNA primase activity
A4V03_RS03620	COG3344	reverse transcriptase
A4V03_RS03700	COG2198	Histidine kinase
A4V03_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS03700	COG2205	protein histidine kinase activity
A4V03_RS03700	COG0784	Response regulator, receiver
A4V03_RS03840	COG4974	Belongs to the 'phage' integrase family
A4V03_RS03845	COG1309	transcriptional regulator
A4V03_RS03855	COG3344	reverse transcriptase
A4V03_RS03875	COG4974	Belongs to the 'phage' integrase family
A4V03_RS03900	COG0551	DNA topoisomerase type I activity
A4V03_RS03900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V03_RS03940	COG0534	Mate efflux family protein
A4V03_RS03945	COG0564	pseudouridine synthase activity
A4V03_RS03965	COG0346	lactoylglutathione lyase activity
A4V03_RS04000	COG0582	viral genome integration into host DNA
A4V03_RS04015	COG3177	Filamentation induced by cAMP protein fic
A4V03_RS04045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4V03_RS04180	COG1910	domain protein
A4V03_RS04205	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V03_RS04230	COG4864	UPF0365 protein
A4V03_RS04245	COG0037	tRNA processing
A4V03_RS04265	COG1477	protein flavinylation
A4V03_RS04270	COG1971	Probably functions as a manganese efflux pump
A4V03_RS04285	COG0463	Glycosyl transferase, family 2
A4V03_RS04305	COG1895	HEPN domain
A4V03_RS04315	COG0148	phosphopyruvate hydratase activity
A4V03_RS04340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4V03_RS04345	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS04350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V03_RS04355	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS04360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4V03_RS04365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V03_RS04365	COG4651	solute:proton antiporter activity
A4V03_RS04375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V03_RS04380	COG0193	aminoacyl-tRNA hydrolase activity
A4V03_RS04385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4V03_RS04395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V03_RS04400	COG1862	Preprotein translocase
A4V03_RS04410	COG0237	dephospho-CoA kinase activity
A4V03_RS04420	COG0542	response to heat
A4V03_RS04435	COG0583	DNA-binding transcription factor activity
A4V03_RS04480	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS04500	COG2855	membrane
A4V03_RS04505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V03_RS04510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4V03_RS04525	COG0443	Heat shock 70 kDa protein
A4V03_RS04585	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04595	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04695	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4V03_RS04705	COG1940	carbohydrate kinase activity
A4V03_RS04715	COG3119	arylsulfatase activity
A4V03_RS04725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS04730	COG0702	epimerase
A4V03_RS04735	COG4771	TonB-dependent receptor
A4V03_RS04745	COG5434	Belongs to the glycosyl hydrolase 28 family
A4V03_RS04750	COG0745	RESPONSE REGULATOR receiver
A4V03_RS04750	COG2205	protein histidine kinase activity
A4V03_RS04750	COG3292	Two component regulator propeller
A4V03_RS04755	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4V03_RS04760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V03_RS04770	COG3250	beta-galactosidase activity
A4V03_RS04790	COG0641	radical SAM
A4V03_RS04795	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04810	COG4372	Transposase
A4V03_RS04845	COG5433	transposase activity
A4V03_RS04925	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04945	COG3344	reverse transcriptase
A4V03_RS04955	COG1475	DNA binding
A4V03_RS05075	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4V03_RS05080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS05150	COG0739	heme binding
A4V03_RS05160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS05170	COG1484	DNA-dependent DNA replication
A4V03_RS05175	COG4584	PFAM Integrase catalytic
A4V03_RS05215	COG4372	Transposase
A4V03_RS05270	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05290	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05295	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05300	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05370	COG4584	PFAM Integrase catalytic
A4V03_RS05375	COG1484	DNA-dependent DNA replication
A4V03_RS05385	COG1760	l-serine dehydratase
A4V03_RS05390	COG1193	negative regulation of DNA recombination
A4V03_RS05400	COG4335	DNA alkylation repair
A4V03_RS05430	COG4804	nuclease activity
A4V03_RS05440	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05465	COG1484	DNA-dependent DNA replication
A4V03_RS05470	COG4584	PFAM Integrase catalytic
A4V03_RS05480	COG3344	reverse transcriptase
A4V03_RS05510	COG4372	Transposase
A4V03_RS05535	COG4584	PFAM Integrase catalytic
A4V03_RS05540	COG1484	DNA-dependent DNA replication
A4V03_RS05575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A4V03_RS05585	COG0561	phosphatase activity
A4V03_RS05590	COG1169	isochorismate synthase
A4V03_RS05595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4V03_RS05600	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4V03_RS05605	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS05625	COG0662	Cupin 2, conserved barrel domain protein
A4V03_RS05625	COG2207	Transcriptional regulator
A4V03_RS05630	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS05670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS05680	COG1253	flavin adenine dinucleotide binding
A4V03_RS05685	COG0501	Belongs to the peptidase M48B family
A4V03_RS05705	COG0482	sulfurtransferase activity
A4V03_RS05720	COG2197	response regulator
A4V03_RS05740	COG2814	Major facilitator Superfamily
A4V03_RS05745	COG4953	penicillin-binding protein 1C
A4V03_RS05750	COG2373	Large extracellular alpha-helical protein
A4V03_RS05755	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS05795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V03_RS05800	COG0646	methionine synthase
A4V03_RS05800	COG1410	methionine synthase
A4V03_RS05805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4V03_RS05810	COG0572	uridine kinase
A4V03_RS05820	COG4232	protein-disulfide reductase activity
A4V03_RS05850	COG4771	TonB-dependent receptor
A4V03_RS05855	COG0702	epimerase
A4V03_RS05880	COG2271	Major facilitator Superfamily
A4V03_RS05900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V03_RS05905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V03_RS05910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V03_RS05915	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V03_RS05925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V03_RS05925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4V03_RS05935	COG1773	rubredoxin
A4V03_RS05935	COG1592	Rubrerythrin
A4V03_RS05950	COG3118	belongs to the thioredoxin family
A4V03_RS05955	COG3591	Belongs to the peptidase S1B family
A4V03_RS05960	COG3591	Belongs to the peptidase S1B family
A4V03_RS05965	COG0641	radical SAM
A4V03_RS05980	COG4974	Belongs to the 'phage' integrase family
A4V03_RS06015	COG0551	DNA topoisomerase type I activity
A4V03_RS06015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V03_RS06040	COG0582	viral genome integration into host DNA
A4V03_RS06185	COG0358	DNA primase activity
A4V03_RS06250	COG0420	3'-5' exonuclease activity
A4V03_RS06270	COG0646	methionine synthase
A4V03_RS06270	COG1410	methionine synthase
A4V03_RS06275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V03_RS06280	COG0463	Glycosyl transferase, family 2
A4V03_RS06285	COG5433	transposase activity
A4V03_RS06290	COG5433	transposase activity
A4V03_RS06305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V03_RS06310	COG1032	radical SAM domain protein
A4V03_RS06330	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS06335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V03_RS06350	COG1131	(ABC) transporter
A4V03_RS06385	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS06410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS06420	COG3757	hydrolase, family 25
A4V03_RS06425	COG2264	protein methyltransferase activity
A4V03_RS06440	COG0590	tRNA wobble adenosine to inosine editing
A4V03_RS06445	COG0673	inositol 2-dehydrogenase activity
A4V03_RS06500	COG0698	ribose 5-phosphate isomerase
A4V03_RS06505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V03_RS06520	COG1070	Carbohydrate kinase
A4V03_RS06525	COG2160	L-arabinose isomerase activity
A4V03_RS06565	COG4771	TonB-dependent receptor
A4V03_RS06570	COG0745	RESPONSE REGULATOR receiver
A4V03_RS06570	COG3292	Two component regulator propeller
A4V03_RS06570	COG2205	protein histidine kinase activity
A4V03_RS06575	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS06590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V03_RS06605	COG1482	cell wall glycoprotein biosynthetic process
A4V03_RS06630	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4V03_RS06635	COG3273	potassium ion transport
A4V03_RS06635	COG0471	metal ion transport
A4V03_RS06640	COG0529	Catalyzes the synthesis of activated sulfate
A4V03_RS06645	COG0175	sulfate reduction
A4V03_RS06650	COG2895	sulfate adenylyltransferase (ATP) activity
A4V03_RS06670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4V03_RS06675	COG0242	peptide deformylase activity
A4V03_RS06685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V03_RS06690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4V03_RS06695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4V03_RS06700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4V03_RS06710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V03_RS06715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V03_RS06720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V03_RS06720	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS06720	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS06720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V03_RS06730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4V03_RS06740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V03_RS06755	COG1940	carbohydrate kinase activity
A4V03_RS06770	COG2814	Major facilitator Superfamily
A4V03_RS06780	COG4771	TonB-dependent receptor
A4V03_RS06850	COG1629	transport
A4V03_RS06880	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS06885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS06895	COG0484	heat shock protein binding
A4V03_RS06900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V03_RS06905	COG0488	(ABC) transporter
A4V03_RS06935	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS06950	COG2183	response to ionizing radiation
A4V03_RS06975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4V03_RS06990	COG0490	domain, Protein
A4V03_RS06990	COG2985	domain, Protein
A4V03_RS06995	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A4V03_RS07005	COG1022	Amp-dependent synthetase and ligase
A4V03_RS07010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V03_RS07015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4V03_RS07025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4V03_RS07030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4V03_RS07035	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS07055	COG0577	efflux transmembrane transporter activity
A4V03_RS07055	COG1136	(ABC) transporter
A4V03_RS07060	COG1136	(ABC) transporter
A4V03_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS07090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V03_RS07095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V03_RS07125	COG2885	chlorophyll binding
A4V03_RS07130	COG0657	acetylesterase activity
A4V03_RS07130	COG2755	lipolytic protein G-D-S-L family
A4V03_RS07140	COG0488	(ABC) transporter
A4V03_RS07170	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS07190	COG1805	sodium ion transport
A4V03_RS07195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4V03_RS07210	COG2871	sodium ion transport
A4V03_RS07215	COG0513	Belongs to the DEAD box helicase family
A4V03_RS07225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4V03_RS07240	COG1739	Uncharacterized protein family UPF0029
A4V03_RS07255	COG0778	Nitroreductase
A4V03_RS07270	COG4372	Transposase
A4V03_RS07285	COG4372	Transposase
A4V03_RS07290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V03_RS07290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V03_RS07295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V03_RS07300	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V03_RS07325	COG2217	Heavy metal translocating P-type atpase
A4V03_RS07335	COG0321	lipoyl(octanoyl) transferase activity
A4V03_RS07345	COG2755	lipolytic protein G-D-S-L family
A4V03_RS07345	COG0657	acetylesterase activity
A4V03_RS07365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V03_RS07375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V03_RS07390	COG1678	Uncharacterized ACR, COG1678
A4V03_RS07450	COG4804	nuclease activity
A4V03_RS07460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V03_RS07460	COG0551	DNA topoisomerase type I activity
A4V03_RS07465	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07470	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07475	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07620	COG1475	DNA binding
A4V03_RS07625	COG4474	Belongs to the UPF0398 family
A4V03_RS07665	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4V03_RS07840	COG1475	DNA binding
A4V03_RS07850	COG1192	Involved in chromosome partitioning
A4V03_RS07885	COG0741	lytic transglycosylase activity
A4V03_RS07885	COG1196	nuclear chromosome segregation
A4V03_RS07885	COG0739	heme binding
A4V03_RS07945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS08020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V03_RS08025	COG1120	ATPase activity
A4V03_RS08125	COG3969	phosphoadenosine phosphosulfate
A4V03_RS08130	COG1475	DNA binding
A4V03_RS08150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V03_RS08155	COG3537	Alpha-1,2-mannosidase
A4V03_RS08180	COG1629	transport
A4V03_RS08180	COG4206	TonB-dependent receptor
A4V03_RS08205	COG2966	Psort location CytoplasmicMembrane, score
A4V03_RS08235	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08235	COG3292	Two component regulator propeller
A4V03_RS08235	COG2205	protein histidine kinase activity
A4V03_RS08235	COG3292	Two component regulator propeller
A4V03_RS08235	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08235	COG2205	protein histidine kinase activity
A4V03_RS08255	COG0442	prolyl-tRNA aminoacylation
A4V03_RS08260	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08265	COG5002	protein histidine kinase activity
A4V03_RS08285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V03_RS08295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V03_RS08300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4V03_RS08305	COG0552	protein localization to endoplasmic reticulum
A4V03_RS08310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS08325	COG0714	Associated with various cellular activities
A4V03_RS08340	COG2304	oxidoreductase activity
A4V03_RS08380	COG4372	Transposase
A4V03_RS08395	COG0542	response to heat
A4V03_RS08400	COG0326	Molecular chaperone. Has ATPase activity
A4V03_RS08405	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS08440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V03_RS08445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V03_RS08450	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V03_RS08455	COG0167	dihydroorotate dehydrogenase activity
A4V03_RS08460	COG0543	2 iron, 2 sulfur cluster binding
A4V03_RS08475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V03_RS08490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4V03_RS08515	COG1132	(ABC) transporter
A4V03_RS08570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V03_RS08575	COG1597	lipid kinase activity
A4V03_RS08580	COG0156	8-amino-7-oxononanoate synthase activity
A4V03_RS08615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4V03_RS08620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V03_RS08650	COG3830	Belongs to the UPF0237 family
A4V03_RS08650	COG0560	Phosphoserine phosphatase
A4V03_RS08655	COG0513	Belongs to the DEAD box helicase family
A4V03_RS08695	COG4372	Transposase
A4V03_RS08740	COG0246	Mannitol dehydrogenase
A4V03_RS08745	COG1609	Transcriptional regulator
A4V03_RS08750	COG1904	glucuronate isomerase
A4V03_RS08775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V03_RS08810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V03_RS08825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4V03_RS08835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V03_RS08840	COG2814	Major facilitator Superfamily
A4V03_RS08840	COG0477	Major facilitator Superfamily
A4V03_RS08845	COG2115	Belongs to the xylose isomerase family
A4V03_RS08860	COG0351	phosphomethylpyrimidine kinase
A4V03_RS08865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V03_RS08870	COG0724	RNA recognition motif
A4V03_RS08880	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V03_RS08900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V03_RS08915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V03_RS08945	COG2205	protein histidine kinase activity
A4V03_RS08950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V03_RS08965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4V03_RS08975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4V03_RS09000	COG4372	Transposase
A4V03_RS09020	COG3475	LICD family
A4V03_RS09035	COG1216	Glycosyl transferase, family 2
A4V03_RS09075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V03_RS09095	COG4974	Belongs to the 'phage' integrase family
A4V03_RS09115	COG0540	Belongs to the ATCase OTCase family
A4V03_RS09120	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A4V03_RS09135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4V03_RS09140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V03_RS09145	COG2985	domain, Protein
A4V03_RS09160	COG2207	Transcriptional regulator
A4V03_RS09165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS09170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V03_RS09175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V03_RS09180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V03_RS09185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4V03_RS09190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V03_RS09195	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V03_RS09205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V03_RS09210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V03_RS09215	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A4V03_RS09220	COG0454	-acetyltransferase
A4V03_RS09245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V03_RS09255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V03_RS09260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V03_RS09285	COG3829	transcription factor binding
A4V03_RS09290	COG2233	PERMEase
A4V03_RS09295	COG3263	regulation of cellular component size
A4V03_RS09300	COG1022	Amp-dependent synthetase and ligase
A4V03_RS09395	COG0681	Belongs to the peptidase S26 family
A4V03_RS09470	COG0210	DNA helicase
A4V03_RS09490	COG0352	thiamine-phosphate diphosphorylase activity
A4V03_RS09495	COG2022	thiamine diphosphate biosynthetic process
A4V03_RS09500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4V03_RS09510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V03_RS09515	COG0352	thiamine-phosphate diphosphorylase activity
A4V03_RS09550	COG0358	DNA primase activity
A4V03_RS09550	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS09570	COG1484	DNA-dependent DNA replication
A4V03_RS09575	COG4584	PFAM Integrase catalytic
A4V03_RS09580	COG0574	Belongs to the PEP-utilizing enzyme family
A4V03_RS09580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V03_RS09585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V03_RS09590	COG0564	pseudouridine synthase activity
A4V03_RS09615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V03_RS09645	COG4372	Transposase
A4V03_RS09650	COG0714	Associated with various cellular activities
A4V03_RS09680	COG3339	Conserved Protein
A4V03_RS09735	COG0024	Methionine aminopeptidase
A4V03_RS09745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4V03_RS09750	COG0481	GTPase activity
A4V03_RS09780	COG0217	transcriptional regulatory protein
A4V03_RS09785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS09785	COG0072	phenylalanine-tRNA ligase activity
A4V03_RS09790	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS09795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V03_RS09800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V03_RS09805	COG4657	Part of a membrane complex involved in electron transport
A4V03_RS09810	COG4660	Part of a membrane complex involved in electron transport
A4V03_RS09815	COG4659	FMN binding
A4V03_RS09820	COG4658	electron transport chain
A4V03_RS09825	COG4656	Part of a membrane complex involved in electron transport
A4V03_RS09935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V03_RS09950	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS09960	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS09965	COG3475	LICD family
A4V03_RS09975	COG2244	polysaccharide biosynthetic process
A4V03_RS09990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V03_RS10015	COG0504	CTP synthase activity
A4V03_RS10020	COG0706	membrane insertase activity
A4V03_RS10025	COG0534	Mate efflux family protein
A4V03_RS10030	COG1506	peptidase
A4V03_RS10030	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS10035	COG1983	PspC domain protein
A4V03_RS10055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V03_RS10065	COG1388	LysM domain
A4V03_RS10065	COG3942	CHAP domain
A4V03_RS10095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V03_RS10100	COG0556	nucleotide-excision repair
A4V03_RS10110	COG2949	membrane
A4V03_RS10115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V03_RS10135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V03_RS10140	COG0505	Belongs to the CarA family
A4V03_RS10150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4V03_RS10155	COG0067	glutamate synthase
A4V03_RS10155	COG0070	glutamate synthase
A4V03_RS10155	COG0069	glutamate synthase activity
A4V03_RS10165	COG0367	asparagine synthase
A4V03_RS10175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V03_RS10180	COG0436	Aminotransferase
A4V03_RS10190	COG0347	Belongs to the P(II) protein family
A4V03_RS10195	COG0004	ammonium transporteR
A4V03_RS10215	COG0133	tryptophan synthase activity
A4V03_RS10220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4V03_RS10230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4V03_RS10235	COG0134	indole-3-glycerol-phosphate synthase activity
A4V03_RS10240	COG0135	phosphoribosylanthranilate isomerase activity
A4V03_RS10245	COG0159	tryptophan synthase activity
A4V03_RS10250	COG0252	asparaginase activity
A4V03_RS10255	COG2197	response regulator
A4V03_RS10265	COG0138	bifunctional purine biosynthesis protein purh
A4V03_RS10275	COG4771	TonB-dependent receptor
A4V03_RS10285	COG0490	domain, Protein
A4V03_RS10285	COG2985	domain, Protein
A4V03_RS10305	COG1609	Transcriptional regulator
A4V03_RS10310	COG2721	sulfolactate sulfo-lyase activity
A4V03_RS10355	COG0681	Belongs to the peptidase S26 family
A4V03_RS10440	COG4452	Inner membrane protein CreD
A4V03_RS10450	COG0228	four-way junction DNA binding
A4V03_RS10475	COG0738	Major facilitator superfamily
A4V03_RS10495	COG1177	transmembrane transport
A4V03_RS10500	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V03_RS10505	COG3842	ATPase activity
A4V03_RS10510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS10515	COG0058	SHG alpha-glucan phosphorylase activity
A4V03_RS10530	COG1269	ATP hydrolysis coupled proton transport
A4V03_RS10545	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V03_RS10615	COG4974	Belongs to the 'phage' integrase family
A4V03_RS10670	COG4804	nuclease activity
A4V03_RS10715	COG1882	Formate acetyltransferase
A4V03_RS10720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V03_RS10725	COG2271	Major facilitator Superfamily
A4V03_RS10740	COG4206	TonB-dependent receptor
A4V03_RS10740	COG1629	transport
A4V03_RS10755	COG1595	DNA-templated transcription, initiation
A4V03_RS10775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4V03_RS10780	COG0583	DNA-binding transcription factor activity
A4V03_RS10785	COG0783	Belongs to the Dps family
A4V03_RS10790	COG0668	transmembrane transport
A4V03_RS10810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V03_RS10815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V03_RS10830	COG1295	ribonuclease BN
A4V03_RS10835	COG4372	Transposase
A4V03_RS10850	COG0778	Nitroreductase
A4V03_RS10860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V03_RS10870	COG0586	Pfam SNARE associated Golgi protein
A4V03_RS10875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4V03_RS10885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V03_RS10890	COG0167	dihydroorotate dehydrogenase activity
A4V03_RS10895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4V03_RS10950	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS10955	COG5039	Polysaccharide pyruvyl transferase
A4V03_RS10970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V03_RS11000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V03_RS11005	COG0497	DNA recombination
A4V03_RS11020	COG0592	DNA-directed DNA polymerase activity
A4V03_RS11040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V03_RS11040	COG0321	lipoyl(octanoyl) transferase activity
A4V03_RS11045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4V03_RS11055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V03_RS11060	COG0156	8-amino-7-oxononanoate synthase activity
A4V03_RS11075	COG0019	diaminopimelate decarboxylase activity
A4V03_RS11080	COG0527	aspartate kinase activity
A4V03_RS11085	COG2884	Cell division ATP-binding protein ftsE
A4V03_RS11090	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V03_RS11090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V03_RS11095	COG0107	imidazoleglycerol-phosphate synthase activity
A4V03_RS11100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4V03_RS11105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V03_RS11110	COG0788	formyltetrahydrofolate deformylase activity
A4V03_RS11130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V03_RS11145	COG3831	ATPase activity
A4V03_RS11145	COG4884	unkown
A4V03_RS11185	COG3546	catalase activity
A4V03_RS11215	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS11215	COG1506	peptidase
A4V03_RS11215	COG4946	Tricorn protease homolog
A4V03_RS11220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4V03_RS11260	COG1312	Catalyzes the dehydration of D-mannonate
A4V03_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS11270	COG1609	Transcriptional regulator
A4V03_RS11280	COG2223	nitrite transmembrane transporter activity
A4V03_RS11290	COG5433	transposase activity
A4V03_RS11300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4V03_RS11300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V03_RS11315	COG2226	methyltransferase
A4V03_RS11335	COG1690	Belongs to the RtcB family
A4V03_RS11355	COG0702	epimerase
A4V03_RS11360	COG4771	TonB-dependent receptor
A4V03_RS11375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V03_RS11395	COG0628	permease
A4V03_RS11400	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS11405	COG1136	(ABC) transporter
A4V03_RS11405	COG0577	efflux transmembrane transporter activity
A4V03_RS11410	COG0436	Aminotransferase
A4V03_RS11435	COG0488	(ABC) transporter
A4V03_RS11455	COG4206	TonB-dependent receptor
A4V03_RS11480	COG0629	single-stranded DNA binding
A4V03_RS11485	COG1194	a g-specific adenine glycosylase
A4V03_RS11495	COG1530	ribonuclease E activity
A4V03_RS11510	COG4191	Histidine kinase
A4V03_RS11515	COG2204	response regulator
A4V03_RS11530	COG1136	(ABC) transporter
A4V03_RS11530	COG0577	efflux transmembrane transporter activity
A4V03_RS11540	COG1136	(ABC) transporter
A4V03_RS11550	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4V03_RS11555	COG0295	cytidine deaminase activity
A4V03_RS11565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V03_RS11570	COG0488	(ABC) transporter
A4V03_RS11580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V03_RS11600	COG4206	TonB-dependent receptor
A4V03_RS11600	COG1629	transport
A4V03_RS11610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS11615	COG0562	UDP-galactopyranose mutase
A4V03_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS11630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS11645	COG1216	Glycosyl transferase, family 2
A4V03_RS11645	COG0463	Glycosyl transferase, family 2
A4V03_RS11685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V03_RS11690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4V03_RS11695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4V03_RS11725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V03_RS11745	COG0346	lactoylglutathione lyase activity
A4V03_RS11815	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS11880	COG3177	Filamentation induced by cAMP protein fic
A4V03_RS11890	COG1396	sequence-specific DNA binding
A4V03_RS11905	COG1396	sequence-specific DNA binding
A4V03_RS11910	COG4584	PFAM Integrase catalytic
A4V03_RS11915	COG1484	DNA-dependent DNA replication
A4V03_RS11925	COG1309	transcriptional regulator
A4V03_RS11945	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12025	COG1484	DNA-dependent DNA replication
A4V03_RS12030	COG4584	PFAM Integrase catalytic
A4V03_RS12050	COG1918	ferrous iron import across plasma membrane
A4V03_RS12050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V03_RS12055	COG0037	tRNA processing
A4V03_RS12070	COG3119	arylsulfatase activity
A4V03_RS12075	COG0534	Mate efflux family protein
A4V03_RS12080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V03_RS12085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V03_RS12110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V03_RS12135	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS12150	COG0668	transmembrane transport
A4V03_RS12155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4V03_RS12165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4V03_RS12175	COG4372	Transposase
A4V03_RS12200	COG1119	ATPase activity
A4V03_RS12205	COG3661	Belongs to the glycosyl hydrolase 67 family
A4V03_RS12220	COG2211	Major facilitator Superfamily
A4V03_RS12230	COG1523	belongs to the glycosyl hydrolase 13 family
A4V03_RS12235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4V03_RS12285	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12325	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12330	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12335	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4V03_RS12345	COG2814	Major facilitator Superfamily
A4V03_RS12350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V03_RS12355	COG0126	phosphoglycerate kinase activity
A4V03_RS12370	COG2311	Membrane
A4V03_RS12380	COG0424	maF-like protein
A4V03_RS12400	COG0778	Nitroreductase
A4V03_RS12410	COG0288	reversible hydration of carbon dioxide
A4V03_RS12425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V03_RS12435	COG0511	ligase activity, forming carbon-carbon bonds
A4V03_RS12440	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V03_RS12445	COG0191	fructose-bisphosphate aldolase activity
A4V03_RS12450	COG0254	rRNA binding
A4V03_RS12455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS12470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V03_RS12485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V03_RS12490	COG0573	inorganic phosphate transmembrane transporter activity
A4V03_RS12510	COG5002	protein histidine kinase activity
A4V03_RS12515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V03_RS12530	COG1280	lysine exporter protein (LysE YggA)
A4V03_RS12550	COG1649	PFAM Uncharacterised BCR, COG1649
A4V03_RS12570	COG1966	Carbon starvation protein
A4V03_RS12575	COG1649	PFAM Uncharacterised BCR, COG1649
A4V03_RS12600	COG0745	RESPONSE REGULATOR receiver
A4V03_RS12600	COG3292	Two component regulator propeller
A4V03_RS12600	COG2205	protein histidine kinase activity
A4V03_RS12620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4V03_RS12620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V03_RS12630	COG1621	beta-fructofuranosidase activity
A4V03_RS12635	COG0702	epimerase
A4V03_RS12640	COG1629	transport
A4V03_RS12645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V03_RS12655	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS12695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4V03_RS12700	COG1960	acyl-CoA dehydrogenase activity
A4V03_RS12705	COG1956	GAF domain-containing protein
A4V03_RS12715	COG0484	heat shock protein binding
A4V03_RS12760	COG0459	protein refolding
A4V03_RS12765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V03_RS12780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V03_RS12790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V03_RS12795	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS12795	COG1506	peptidase
A4V03_RS12800	COG0124	histidyl-tRNA synthetase
A4V03_RS12825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V03_RS12860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4V03_RS12865	COG1368	sulfuric ester hydrolase activity
A4V03_RS12870	COG0671	phosphoesterase, PA-phosphatase related
A4V03_RS12875	COG0473	3-isopropylmalate dehydrogenase activity
A4V03_RS12885	COG0066	3-isopropylmalate dehydratase activity
A4V03_RS12890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V03_RS12895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V03_RS12955	COG0714	Associated with various cellular activities
A4V03_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS12970	COG0439	Biotin carboxylase
A4V03_RS12975	COG4770	biotin carboxylase activity
A4V03_RS12980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V03_RS12990	COG2873	o-acetylhomoserine
A4V03_RS12995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V03_RS13005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4V03_RS13010	COG1088	dTDP-glucose 4,6-dehydratase activity
A4V03_RS13015	COG1575	Belongs to the MenA family. Type 1 subfamily
A4V03_RS13025	COG5433	transposase activity
A4V03_RS13035	COG1408	metallophosphoesterase
A4V03_RS13040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V03_RS13050	COG0194	GDP metabolic process
A4V03_RS13070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V03_RS13075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4V03_RS13085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V03_RS13090	COG0750	zinc metalloprotease
A4V03_RS13100	COG1328	CTP reductase activity
A4V03_RS13110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V03_RS13125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V03_RS13140	COG3550	peptidyl-serine autophosphorylation
A4V03_RS13235	COG1505	serine-type exopeptidase activity
A4V03_RS13250	COG0617	tRNA 3'-terminal CCA addition
A4V03_RS13265	COG0632	four-way junction helicase activity
A4V03_RS13270	COG0673	inositol 2-dehydrogenase activity
A4V03_RS13290	COG4372	Transposase
A4V03_RS13310	COG0488	(ABC) transporter
A4V03_RS13355	COG1595	DNA-templated transcription, initiation
A4V03_RS13370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4V03_RS13380	COG1522	sequence-specific DNA binding
A4V03_RS13410	COG0811	peptide transport
A4V03_RS13420	COG0084	hydrolase, TatD family'
A4V03_RS13440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4V03_RS13445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V03_RS13450	COG0205	6-phosphofructokinase activity
A4V03_RS13485	COG0372	Belongs to the citrate synthase family
A4V03_RS13495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V03_RS13500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4V03_RS13505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V03_RS13520	COG0028	Belongs to the TPP enzyme family
A4V03_RS13525	COG0129	dihydroxy-acid dehydratase activity
A4V03_RS13535	COG3681	Belongs to the UPF0597 family
A4V03_RS13545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4V03_RS13555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V03_RS13560	COG0581	inorganic phosphate transmembrane transporter activity
A4V03_RS13565	COG0573	inorganic phosphate transmembrane transporter activity
A4V03_RS13580	COG4206	TonB-dependent receptor
A4V03_RS13580	COG1629	transport
A4V03_RS13595	COG0745	RESPONSE REGULATOR receiver
A4V03_RS13600	COG5002	protein histidine kinase activity
A4V03_RS13625	COG3250	beta-galactosidase activity
A4V03_RS13640	COG1733	regulation of RNA biosynthetic process
A4V03_RS13655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4V03_RS13660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13670	COG2985	domain, Protein
A4V03_RS13670	COG0569	domain protein
A4V03_RS13715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V03_RS13740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V03_RS13745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V03_RS13750	COG0166	Belongs to the GPI family
A4V03_RS13785	COG2502	aspartate--ammonia ligase
A4V03_RS13790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4V03_RS13805	COG3876	Protein conserved in bacteria
A4V03_RS13815	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS13825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V03_RS13830	COG0778	Nitroreductase
A4V03_RS13840	COG1640	4-alpha-glucanotransferase
A4V03_RS13850	COG1803	Methylglyoxal synthase
A4V03_RS13855	COG1216	Glycosyl transferase, family 2
A4V03_RS13865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS13870	COG1022	Amp-dependent synthetase and ligase
A4V03_RS13905	COG0359	binds to the 23S rRNA
A4V03_RS13910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V03_RS13915	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V03_RS13935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V03_RS13940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V03_RS13975	COG2431	L-lysine efflux transmembrane transporter activity
A4V03_RS14005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4V03_RS14020	COG2234	aminopeptidase activity
A4V03_RS14035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4V03_RS14040	COG0802	atpase or kinase
A4V03_RS14065	COG0714	Associated with various cellular activities
A4V03_RS14100	COG3118	belongs to the thioredoxin family
A4V03_RS14110	COG0688	phosphatidylethanolamine metabolic process
A4V03_RS14115	COG1183	phosphatidylcholine synthase activity
A4V03_RS14135	COG0792	nuclease activity
A4V03_RS14155	COG1595	DNA-templated transcription, initiation
A4V03_RS14170	COG1629	transport
A4V03_RS14175	COG0702	epimerase
A4V03_RS14190	COG3408	Glycogen debranching enzyme
A4V03_RS14195	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS14200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4V03_RS14220	COG0534	Mate efflux family protein
A4V03_RS14225	COG0528	UMP kinase activity
A4V03_RS14235	COG0233	cytoplasmic translational termination
A4V03_RS14240	COG1162	GTPase activity
A4V03_RS14250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V03_RS14265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V03_RS14265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V03_RS14275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V03_RS14285	COG1629	transport
A4V03_RS14285	COG4206	TonB-dependent receptor
A4V03_RS14305	COG4206	TonB-dependent receptor
A4V03_RS14305	COG1629	transport
A4V03_RS14310	COG5433	transposase activity
A4V03_RS14315	COG4974	Belongs to the 'phage' integrase family
A4V03_RS14320	COG4206	TonB-dependent receptor
A4V03_RS14320	COG1629	transport
A4V03_RS14335	COG2095	MarC family integral membrane protein
A4V03_RS14350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V03_RS14360	COG1435	thymidine kinase activity
A4V03_RS14365	COG0628	permease
A4V03_RS14425	COG0534	Mate efflux family protein
A4V03_RS14435	COG2205	protein histidine kinase activity
A4V03_RS14435	COG2198	Histidine kinase
A4V03_RS14435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS14435	COG0784	Response regulator, receiver
A4V03_RS14445	COG4372	Transposase
A4V03_RS14500	COG1733	regulation of RNA biosynthetic process
A4V03_RS14510	COG4413	Urea transporter
A4V03_RS14545	COG0475	glutathione-regulated potassium exporter activity
A4V03_RS14545	COG0589	response to stress
A4V03_RS14555	COG1522	sequence-specific DNA binding
A4V03_RS14570	COG0693	protein deglycase activity
A4V03_RS14575	COG0668	transmembrane transport
A4V03_RS14595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4V03_RS14600	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A4V03_RS14605	COG0527	aspartate kinase activity
A4V03_RS14605	COG0460	homoserine dehydrogenase
A4V03_RS14610	COG0252	asparaginase activity
A4V03_RS14615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V03_RS14620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V03_RS14635	COG4771	TonB-dependent receptor
A4V03_RS14650	COG0826	peptidase U32
A4V03_RS14655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V03_RS14670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4V03_RS14705	COG4771	TonB-dependent receptor
A4V03_RS14775	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS14805	COG0702	epimerase
A4V03_RS14810	COG4771	TonB-dependent receptor
A4V03_RS14830	COG0471	metal ion transport
A4V03_RS14835	COG3292	Two component regulator propeller
A4V03_RS14835	COG2205	protein histidine kinase activity
A4V03_RS14835	COG0745	RESPONSE REGULATOR receiver
A4V03_RS14835	COG3292	Two component regulator propeller
A4V03_RS14835	COG2205	protein histidine kinase activity
A4V03_RS14835	COG0745	RESPONSE REGULATOR receiver
A4V03_RS14845	COG0616	signal peptide processing
A4V03_RS14850	COG1663	tetraacyldisaccharide 4'-kinase activity
A4V03_RS14855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4V03_RS14860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4V03_RS14880	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS14910	COG1629	transport
A4V03_RS14915	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS14925	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS14930	COG0657	acetylesterase activity
A4V03_RS14930	COG2755	lipolytic protein G-D-S-L family
A4V03_RS14940	COG3940	Belongs to the glycosyl hydrolase 43 family
A4V03_RS14945	COG3250	beta-galactosidase activity
A4V03_RS14965	COG1629	transport
A4V03_RS14965	COG4206	TonB-dependent receptor
A4V03_RS15000	COG0745	RESPONSE REGULATOR receiver
A4V03_RS15000	COG2205	protein histidine kinase activity
A4V03_RS15000	COG3292	Two component regulator propeller
A4V03_RS15015	COG4206	TonB-dependent receptor
A4V03_RS15015	COG1629	transport
A4V03_RS15035	COG5433	transposase activity
A4V03_RS15040	COG0582	viral genome integration into host DNA
A4V03_RS15045	COG4974	Belongs to the 'phage' integrase family
A4V03_RS15070	COG2204	response regulator
A4V03_RS15090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS15100	COG1368	sulfuric ester hydrolase activity
A4V03_RS15245	COG1192	Involved in chromosome partitioning
A4V03_RS15370	COG0484	heat shock protein binding
A4V03_RS15440	COG1404	Belongs to the peptidase S8 family
A4V03_RS15470	COG4206	TonB-dependent receptor
A4V03_RS15470	COG1629	transport
A4V03_RS15475	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V03_RS15495	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS15500	COG0737	Belongs to the 5'-nucleotidase family
A4V03_RS15505	COG0737	Belongs to the 5'-nucleotidase family
A4V03_RS15510	COG0335	large ribosomal subunit rRNA binding
A4V03_RS15525	COG0577	efflux transmembrane transporter activity
A4V03_RS15525	COG1136	(ABC) transporter
A4V03_RS15530	COG1136	(ABC) transporter
A4V03_RS15530	COG0577	efflux transmembrane transporter activity
A4V03_RS15535	COG0577	efflux transmembrane transporter activity
A4V03_RS15535	COG1136	(ABC) transporter
A4V03_RS15560	COG2996	Protein conserved in bacteria
A4V03_RS15565	COG0582	viral genome integration into host DNA
A4V03_RS15585	COG0732	type I restriction modification DNA specificity domain
A4V03_RS15610	COG0039	L-malate dehydrogenase activity
A4V03_RS15620	COG2217	Heavy metal translocating P-type atpase
A4V03_RS15625	COG1373	ATPase (AAA superfamily
A4V03_RS15640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V03_RS15645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V03_RS15650	COG0509	glycine decarboxylation via glycine cleavage system
A4V03_RS15665	COG0006	proline dipeptidase activity
A4V03_RS15680	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4V03_RS15685	COG1773	rubredoxin
A4V03_RS15690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V03_RS15695	COG1011	Hydrolase
A4V03_RS15700	COG0196	riboflavin kinase activity
A4V03_RS15705	COG1266	CAAX protease self-immunity
A4V03_RS15710	COG2166	iron-sulfur cluster assembly
A4V03_RS15715	COG2234	aminopeptidase activity
A4V03_RS15720	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4V03_RS15725	COG0280	phosphate acetyltransferase
A4V03_RS15730	COG3426	butyrate kinase activity
A4V03_RS15735	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V03_RS15745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V03_RS15765	COG2066	Belongs to the glutaminase family
A4V03_RS15845	COG4656	Part of a membrane complex involved in electron transport
A4V03_RS15915	COG0110	maltose O-acetyltransferase activity
A4V03_RS15960	COG4974	Belongs to the 'phage' integrase family
A4V03_RS15965	COG4584	PFAM Integrase catalytic
A4V03_RS15970	COG1484	DNA-dependent DNA replication
A4V03_RS15975	COG5433	transposase activity
A4V03_RS15995	COG3345	alpha-galactosidase
A4V03_RS16055	COG0667	Aldo Keto reductase
A4V03_RS16110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS16120	COG1309	transcriptional regulator
A4V03_RS16125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS16135	COG4771	TonB-dependent receptor
A4V03_RS16165	COG4372	Transposase
A4V03_RS16190	COG0203	ribosomal protein L17
A4V03_RS16195	COG0202	RNA polymerase activity
A4V03_RS16200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V03_RS16205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V03_RS16210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V03_RS16215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V03_RS16230	COG0200	Binds to the 23S rRNA
A4V03_RS16235	COG1841	ribosomal large subunit assembly
A4V03_RS16240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V03_RS16245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4V03_RS16250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V03_RS16255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4V03_RS16260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V03_RS16265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4V03_RS16270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4V03_RS16275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4V03_RS16280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V03_RS16285	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V03_RS16290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V03_RS16295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4V03_RS16300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V03_RS16305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4V03_RS16310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V03_RS16315	COG0089	rRNA binding
A4V03_RS16320	COG0088	Forms part of the polypeptide exit tunnel
A4V03_RS16325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V03_RS16330	COG0051	transcription antitermination factor activity, RNA binding
A4V03_RS16335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V03_RS16340	COG0049	tRNA binding
A4V03_RS16345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V03_RS16355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V03_RS16360	COG0085	RNA polymerase activity
A4V03_RS16365	COG0222	ribosome binding
A4V03_RS16370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4V03_RS16375	COG0081	regulation of translation
A4V03_RS16380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4V03_RS16390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V03_RS16400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V03_RS16430	COG4974	Belongs to the 'phage' integrase family
A4V03_RS16435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V03_RS16440	COG0006	proline dipeptidase activity
A4V03_RS16445	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4V03_RS16460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V03_RS16470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V03_RS16475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V03_RS16490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V03_RS16495	COG0252	asparaginase activity
A4V03_RS16510	COG2096	Adenosyltransferase
A4V03_RS16550	COG1051	belongs to the nudix hydrolase family
A4V03_RS16555	COG0546	phosphoglycolate phosphatase activity
A4V03_RS16565	COG4974	Belongs to the 'phage' integrase family
A4V03_RS16570	COG4804	nuclease activity
A4V03_RS16665	COG0662	Cupin 2, conserved barrel domain protein
A4V03_RS16665	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A4V03_RS16670	COG0318	PFAM AMP-dependent synthetase and ligase
A4V03_RS16675	COG1396	sequence-specific DNA binding
A4V03_RS16680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V03_RS16700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4V03_RS16705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4V03_RS16750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4V03_RS16755	COG0793	Belongs to the peptidase S41A family
A4V03_RS16775	COG1040	competence protein
A4V03_RS16820	COG2610	gluconate transmembrane transporter activity
A4V03_RS16825	COG1929	Belongs to the glycerate kinase type-1 family
A4V03_RS16845	COG1629	transport
A4V03_RS16850	COG5433	transposase activity
A4V03_RS16855	COG5433	transposase activity
A4V03_RS16870	COG1609	Transcriptional regulator
A4V03_RS16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS16880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS16885	COG4771	TonB-dependent receptor
A4V03_RS16940	COG0018	arginyl-trna synthetase
A4V03_RS16950	COG0705	Rhomboid family
A4V03_RS16965	COG0339	signal peptide processing
A4V03_RS16970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V03_RS17230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V03_RS17285	COG3723	Recombinational DNA repair protein, rece pathway
A4V03_RS17290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS17350	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS17350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V03_RS17355	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS17360	COG1373	ATPase (AAA superfamily
A4V03_RS17365	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4V03_RS17370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V03_RS17390	COG4974	Belongs to the 'phage' integrase family
A4V03_RS17405	COG0606	chelatase, subunit chli
A4V03_RS17410	COG2205	protein histidine kinase activity
A4V03_RS17415	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS17435	COG0702	epimerase
A4V03_RS17440	COG4771	TonB-dependent receptor
A4V03_RS17450	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS17455	COG3119	arylsulfatase activity
A4V03_RS17485	COG3250	beta-galactosidase activity
A4V03_RS17505	COG0702	epimerase
A4V03_RS17510	COG4771	TonB-dependent receptor
A4V03_RS17520	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS17550	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4V03_RS17555	COG1629	transport
A4V03_RS17555	COG4206	TonB-dependent receptor
A4V03_RS17570	COG0673	inositol 2-dehydrogenase activity
A4V03_RS17580	COG0673	inositol 2-dehydrogenase activity
A4V03_RS17590	COG2205	protein histidine kinase activity
A4V03_RS17590	COG3292	Two component regulator propeller
A4V03_RS17590	COG0745	RESPONSE REGULATOR receiver
A4V03_RS17625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS17625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS17640	COG3475	LICD family
A4V03_RS17655	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS17670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V03_RS17675	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS17680	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS17700	COG0561	phosphatase activity
A4V03_RS17750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4V03_RS17755	COG0793	Belongs to the peptidase S41A family
A4V03_RS17755	COG3409	Peptidoglycan-binding domain 1 protein
A4V03_RS17780	COG0702	epimerase
A4V03_RS17785	COG4206	TonB-dependent receptor
A4V03_RS17785	COG1629	transport
A4V03_RS17790	COG3292	Two component regulator propeller
A4V03_RS17790	COG0745	RESPONSE REGULATOR receiver
A4V03_RS17790	COG2205	protein histidine kinase activity
A4V03_RS17810	COG1053	succinate dehydrogenase
A4V03_RS17815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4V03_RS17835	COG0758	DNA mediated transformation
A4V03_RS17845	COG0826	peptidase U32
A4V03_RS17850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V03_RS17865	COG0557	exoribonuclease II activity
A4V03_RS17875	COG5002	protein histidine kinase activity
A4V03_RS17885	COG4206	TonB-dependent receptor
A4V03_RS17885	COG1629	transport
A4V03_RS17900	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS17905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4V03_RS17910	COG1917	Cupin 2, conserved barrel domain protein
A4V03_RS17945	COG0702	epimerase
A4V03_RS17950	COG4771	TonB-dependent receptor
A4V03_RS17990	COG3119	arylsulfatase activity
A4V03_RS17990	COG3408	Glycogen debranching enzyme
A4V03_RS18000	COG2205	protein histidine kinase activity
A4V03_RS18000	COG3292	Two component regulator propeller
A4V03_RS18000	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18005	COG5433	transposase activity
A4V03_RS18020	COG4206	TonB-dependent receptor
A4V03_RS18020	COG1629	transport
A4V03_RS18030	COG4206	TonB-dependent receptor
A4V03_RS18030	COG1629	transport
A4V03_RS18055	COG3119	arylsulfatase activity
A4V03_RS18060	COG2814	Major facilitator Superfamily
A4V03_RS18065	COG0012	GTP binding
A4V03_RS18070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4V03_RS18075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4V03_RS18080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS18085	COG1629	transport
A4V03_RS18125	COG0697	spore germination
A4V03_RS18135	COG3250	beta-galactosidase activity
A4V03_RS18140	COG0495	leucyl-tRNA aminoacylation
A4V03_RS18145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V03_RS18150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V03_RS18155	COG1360	Flagellar Motor Protein
A4V03_RS18160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4V03_RS18195	COG4206	TonB-dependent receptor
A4V03_RS18195	COG1629	transport
A4V03_RS18225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V03_RS18225	COG0731	radical SAM domain protein
A4V03_RS18250	COG0659	secondary active sulfate transmembrane transporter activity
A4V03_RS18255	COG1592	Rubrerythrin
A4V03_RS18265	COG3292	Two component regulator propeller
A4V03_RS18265	COG2205	protein histidine kinase activity
A4V03_RS18265	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18280	COG4771	TonB-dependent receptor
A4V03_RS18295	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V03_RS18320	COG0427	acetyl-CoA hydrolase
A4V03_RS18330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS18370	COG4372	Transposase
A4V03_RS18400	COG2177	Part of the ABC transporter FtsEX involved in
A4V03_RS18410	COG1968	undecaprenyl-diphosphatase activity
A4V03_RS18415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V03_RS18420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V03_RS18425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4V03_RS18435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V03_RS18455	COG0594	ribonuclease P activity
A4V03_RS18460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4V03_RS18470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4V03_RS18480	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V03_RS18485	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS18515	COG4771	TonB-dependent receptor
A4V03_RS18525	COG0726	polysaccharide deacetylase
A4V03_RS18535	COG5433	transposase activity
A4V03_RS18550	COG1121	(ABC) transporter
A4V03_RS18560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4V03_RS18560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V03_RS18565	COG1238	metal cluster binding
A4V03_RS18580	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS18580	COG1506	peptidase
A4V03_RS18590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V03_RS18590	COG0116	Belongs to the methyltransferase superfamily
A4V03_RS18595	COG1045	serine acetyltransferase
A4V03_RS18605	COG3279	Response regulator of the LytR AlgR family
A4V03_RS18620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V03_RS18620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V03_RS18625	COG0142	geranyltranstransferase activity
A4V03_RS18630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4V03_RS18635	COG1694	Mazg nucleotide pyrophosphohydrolase
A4V03_RS18640	COG1490	D-aminoacyl-tRNA deacylase activity
A4V03_RS18650	COG0322	excinuclease ABC activity
A4V03_RS18655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V03_RS18660	COG0445	tRNA wobble uridine modification
A4V03_RS18685	COG3344	reverse transcriptase
A4V03_RS18690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4V03_RS18695	COG2715	membrane protein required for spore maturation
A4V03_RS18700	COG2255	four-way junction helicase activity
A4V03_RS18705	COG2852	Protein conserved in bacteria
A4V03_RS18720	COG3591	Belongs to the peptidase S1B family
A4V03_RS18745	COG0702	epimerase
A4V03_RS18750	COG1629	transport
A4V03_RS18750	COG4206	TonB-dependent receptor
A4V03_RS18760	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18760	COG2205	protein histidine kinase activity
A4V03_RS18760	COG3292	Two component regulator propeller
A4V03_RS18765	COG0513	Belongs to the DEAD box helicase family
A4V03_RS18775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS18790	COG0612	Peptidase, M16
A4V03_RS18840	COG0681	Belongs to the peptidase S26 family
A4V03_RS18850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V03_RS18895	COG5492	domain, Protein
A4V03_RS18905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V03_RS18915	COG0702	epimerase
A4V03_RS18920	COG4771	TonB-dependent receptor
A4V03_RS18925	COG3119	arylsulfatase activity
A4V03_RS18930	COG3292	Two component regulator propeller
A4V03_RS18930	COG2205	protein histidine kinase activity
A4V03_RS18930	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18930	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18930	COG2205	protein histidine kinase activity
A4V03_RS18930	COG3292	Two component regulator propeller
A4V03_RS18945	COG0702	epimerase
A4V03_RS18950	COG1629	transport
A4V03_RS18960	COG1629	transport
A4V03_RS18980	COG0738	Major facilitator superfamily
A4V03_RS18995	COG1940	carbohydrate kinase activity
A4V03_RS19000	COG3250	beta-galactosidase activity
A4V03_RS19010	COG1609	Transcriptional regulator
A4V03_RS19020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS19025	COG1538	Outer membrane efflux protein
A4V03_RS19035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS19040	COG3250	beta-galactosidase activity
A4V03_RS19045	COG4771	TonB-dependent receptor
A4V03_RS19055	COG1629	transport
A4V03_RS19060	COG0702	epimerase
A4V03_RS19095	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS19100	COG3119	arylsulfatase activity
A4V03_RS19105	COG5492	domain, Protein
A4V03_RS19110	COG0215	cysteine-tRNA ligase activity
A4V03_RS19115	COG0561	phosphatase activity
A4V03_RS19135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V03_RS19140	COG0482	sulfurtransferase activity
A4V03_RS19150	COG0205	6-phosphofructokinase activity
A4V03_RS19155	COG0571	ribonuclease III activity
A4V03_RS19160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V03_RS19165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V03_RS19170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V03_RS19175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V03_RS19210	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS19215	COG3475	LICD family
A4V03_RS19220	COG4750	Nucleotidyl transferase
A4V03_RS19230	COG0463	Glycosyl transferase, family 2
A4V03_RS19235	COG0463	Glycosyl transferase, family 2
A4V03_RS19240	COG1216	Glycosyl transferase, family 2
A4V03_RS19255	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS19260	COG1442	glycosyl transferase family 8
A4V03_RS19260	COG1216	Glycosyl transferase, family 2
A4V03_RS19265	COG1216	Glycosyl transferase, family 2
A4V03_RS19315	COG1132	(ABC) transporter
A4V03_RS19320	COG0328	RNA-DNA hybrid ribonuclease activity
A4V03_RS19320	COG3341	Caulimovirus viroplasmin
A4V03_RS19325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V03_RS19335	COG0326	Molecular chaperone. Has ATPase activity
A4V03_RS19345	COG1166	arginine decarboxylase activity
A4V03_RS19350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V03_RS19355	COG1595	DNA-templated transcription, initiation
A4V03_RS19375	COG0779	Required for maturation of 30S ribosomal subunits
A4V03_RS19380	COG0195	Participates in both transcription termination and antitermination
A4V03_RS19385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V03_RS19395	COG0719	Fe-S assembly protein
A4V03_RS19400	COG0396	ATPase activity
A4V03_RS19405	COG0719	Fe-S assembly protein
A4V03_RS19410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4V03_RS19415	COG0393	Putative heavy-metal-binding
A4V03_RS19440	COG2205	protein histidine kinase activity
A4V03_RS19440	COG3292	Two component regulator propeller
A4V03_RS19440	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19440	COG2205	protein histidine kinase activity
A4V03_RS19440	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19440	COG3292	Two component regulator propeller
A4V03_RS19445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V03_RS19490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V03_RS19500	COG0187	DNA topoisomerase II activity
A4V03_RS19505	COG0268	Binds directly to 16S ribosomal RNA
A4V03_RS19515	COG1381	Involved in DNA repair and RecF pathway recombination
A4V03_RS19545	COG5433	transposase activity
A4V03_RS19555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4V03_RS19570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V03_RS19575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V03_RS19580	COG0772	Belongs to the SEDS family
A4V03_RS19585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V03_RS19590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V03_RS19595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V03_RS19610	COG0275	rRNA processing
A4V03_RS19615	COG2001	Belongs to the MraZ family
A4V03_RS19635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V03_RS19640	COG0756	dUTP diphosphatase activity
A4V03_RS19655	COG4942	peptidase
A4V03_RS19660	COG2205	protein histidine kinase activity
A4V03_RS19660	COG3292	Two component regulator propeller
A4V03_RS19660	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19670	COG3119	arylsulfatase activity
A4V03_RS19695	COG4771	TonB-dependent receptor
A4V03_RS19720	COG4771	TonB-dependent receptor
A4V03_RS19730	COG5433	transposase activity
A4V03_RS19735	COG0702	epimerase
A4V03_RS19760	COG4771	TonB-dependent receptor
A4V03_RS19765	COG0702	epimerase
A4V03_RS19785	COG3661	Belongs to the glycosyl hydrolase 67 family
A4V03_RS19815	COG3537	Alpha-1,2-mannosidase
A4V03_RS19820	COG2017	converts alpha-aldose to the beta-anomer
A4V03_RS19985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V03_RS19990	COG1022	Amp-dependent synthetase and ligase
A4V03_RS20010	COG2954	triphosphatase activity
A4V03_RS20065	COG0561	phosphatase activity
A4V03_RS20070	COG4771	TonB-dependent receptor