locus-tag	class	description
A4V03_RS00005	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00015	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00035	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS00040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V03_RS00060	COG3345	alpha-galactosidase
A4V03_RS00090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS00100	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00110	COG0673	inositol 2-dehydrogenase activity
A4V03_RS00120	COG0702	epimerase
A4V03_RS00125	COG4771	TonB-dependent receptor
A4V03_RS00135	COG2814	Major facilitator Superfamily
A4V03_RS00150	COG1609	Transcriptional regulator
A4V03_RS00150	COG2207	Transcriptional regulator
A4V03_RS00160	COG0423	glycine-tRNA ligase activity
A4V03_RS00170	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00180	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS00185	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00200	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00205	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00210	COG4771	TonB-dependent receptor
A4V03_RS00220	COG4206	TonB-dependent receptor
A4V03_RS00220	COG1629	transport
A4V03_RS00225	COG0702	epimerase
A4V03_RS00245	COG2382	esterase
A4V03_RS00255	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00255	COG3292	Two component regulator propeller
A4V03_RS00255	COG2205	protein histidine kinase activity
A4V03_RS00265	COG3693	PFAM glycoside hydrolase, family 10
A4V03_RS00265	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS00265	COG2382	esterase
A4V03_RS00290	COG2211	Major facilitator Superfamily
A4V03_RS00360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4V03_RS00375	COG0589	response to stress
A4V03_RS00375	COG0475	glutathione-regulated potassium exporter activity
A4V03_RS00380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V03_RS00385	COG1136	(ABC) transporter
A4V03_RS00395	COG0733	neurotransmitter:sodium symporter activity
A4V03_RS00405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V03_RS00410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V03_RS00415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4V03_RS00435	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS00445	COG3292	Two component regulator propeller
A4V03_RS00445	COG2205	protein histidine kinase activity
A4V03_RS00445	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00450	COG4771	TonB-dependent receptor
A4V03_RS00460	COG4206	TonB-dependent receptor
A4V03_RS00460	COG1629	transport
A4V03_RS00495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS00510	COG1346	cytolysis
A4V03_RS00515	COG1380	Effector of murein hydrolase LrgA
A4V03_RS00520	COG0280	phosphate acetyltransferase
A4V03_RS00525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4V03_RS00530	COG1349	DNA-binding transcription factor activity
A4V03_RS00535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4V03_RS00545	COG0371	Dehydrogenase
A4V03_RS00550	COG2271	Major facilitator Superfamily
A4V03_RS00555	COG0546	phosphoglycolate phosphatase activity
A4V03_RS00560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS00585	COG1629	transport
A4V03_RS00605	COG1216	Glycosyl transferase, family 2
A4V03_RS00605	COG0463	Glycosyl transferase, family 2
A4V03_RS00610	COG2003	Belongs to the UPF0758 family
A4V03_RS00630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4V03_RS00650	COG1785	Belongs to the alkaline phosphatase family
A4V03_RS00655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4V03_RS00660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V03_RS00665	COG0515	serine threonine protein kinase
A4V03_RS00665	COG2815	serine threonine protein kinase
A4V03_RS00670	COG0564	pseudouridine synthase activity
A4V03_RS00695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V03_RS00700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V03_RS00705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4V03_RS00715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V03_RS00730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4V03_RS00735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4V03_RS00745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V03_RS00745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V03_RS00750	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V03_RS00760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V03_RS00770	COG0165	Argininosuccinate lyase
A4V03_RS00800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4V03_RS00805	COG1396	sequence-specific DNA binding
A4V03_RS00805	COG1917	Cupin 2, conserved barrel domain protein
A4V03_RS00810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V03_RS00815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V03_RS00820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V03_RS00825	COG0137	argininosuccinate synthase activity
A4V03_RS00835	COG1438	arginine binding
A4V03_RS00845	COG1070	Carbohydrate kinase
A4V03_RS00850	COG4806	L-rhamnose isomerase
A4V03_RS00860	COG0235	Class ii aldolase
A4V03_RS00865	COG1454	alcohol dehydrogenase
A4V03_RS00890	COG0564	pseudouridine synthase activity
A4V03_RS00920	COG3537	Alpha-1,2-mannosidase
A4V03_RS00930	COG0745	RESPONSE REGULATOR receiver
A4V03_RS00930	COG2205	protein histidine kinase activity
A4V03_RS00930	COG3292	Two component regulator propeller
A4V03_RS00940	COG1629	transport
A4V03_RS00940	COG4206	TonB-dependent receptor
A4V03_RS00945	COG0702	epimerase
A4V03_RS00975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V03_RS00975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V03_RS00980	COG0612	Peptidase, M16
A4V03_RS00985	COG0534	Mate efflux family protein
A4V03_RS00990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS00990	COG2205	protein histidine kinase activity
A4V03_RS01015	COG1629	transport
A4V03_RS01045	COG0488	(ABC) transporter
A4V03_RS01050	COG3590	peptidase
A4V03_RS01055	COG0138	bifunctional purine biosynthesis protein purh
A4V03_RS01080	COG0772	Belongs to the SEDS family
A4V03_RS01090	COG1774	PSP1 C-terminal conserved region
A4V03_RS01095	COG0470	DNA polymerase III
A4V03_RS01100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V03_RS01155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V03_RS01160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V03_RS01165	COG1160	GTP binding
A4V03_RS01175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4V03_RS01180	COG1127	ABC transporter
A4V03_RS01185	COG0724	RNA recognition motif
A4V03_RS01190	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V03_RS01195	COG0740	serine-type endopeptidase activity
A4V03_RS01200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V03_RS01205	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS01210	COG0517	IMP dehydrogenase activity
A4V03_RS01210	COG0516	GMP reductase activity
A4V03_RS01225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4V03_RS01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4V03_RS01245	COG2885	chlorophyll binding
A4V03_RS01260	COG4206	TonB-dependent receptor
A4V03_RS01260	COG1629	transport
A4V03_RS01295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS01310	COG0612	Peptidase, M16
A4V03_RS01335	COG3022	response to hydroperoxide
A4V03_RS01360	COG1187	pseudouridine synthase activity
A4V03_RS01365	COG0017	Asparaginyl-tRNA synthetase
A4V03_RS01385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4V03_RS01390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4V03_RS01395	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V03_RS01400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V03_RS01410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4V03_RS01415	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V03_RS01420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V03_RS01435	COG0482	sulfurtransferase activity
A4V03_RS01445	COG1570	exodeoxyribonuclease VII activity
A4V03_RS01455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V03_RS01465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V03_RS01470	COG0489	protein tyrosine kinase activity
A4V03_RS01480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4V03_RS01505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS01525	COG0714	Associated with various cellular activities
A4V03_RS01530	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4V03_RS01535	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4V03_RS01540	COG0039	L-malate dehydrogenase activity
A4V03_RS01550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V03_RS01555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4V03_RS01560	COG0811	peptide transport
A4V03_RS01565	COG0848	biopolymer transport protein
A4V03_RS01580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V03_RS01585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V03_RS01595	COG0739	heme binding
A4V03_RS01610	COG0149	triose-phosphate isomerase activity
A4V03_RS01620	COG0302	gtp cyclohydrolase
A4V03_RS01625	COG0358	DNA primase activity
A4V03_RS01635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V03_RS01660	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS01665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4V03_RS01665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V03_RS01675	COG0009	L-threonylcarbamoyladenylate synthase
A4V03_RS01685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4V03_RS01690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V03_RS01695	COG2333	competence protein COMEC
A4V03_RS01695	COG0658	competence protein
A4V03_RS01700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4V03_RS01710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V03_RS01720	COG4771	TonB-dependent receptor
A4V03_RS01730	COG3537	Alpha-1,2-mannosidase
A4V03_RS01735	COG3537	Alpha-1,2-mannosidase
A4V03_RS01745	COG3537	Alpha-1,2-mannosidase
A4V03_RS01750	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS01760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V03_RS01800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V03_RS01815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V03_RS01820	COG0742	ribosomal rna small subunit methyltransferase
A4V03_RS01835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS01870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V03_RS01875	COG5433	transposase activity
A4V03_RS01890	COG0739	heme binding
A4V03_RS01900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V03_RS01905	COG0741	lytic transglycosylase activity
A4V03_RS01905	COG1388	LysM domain
A4V03_RS01915	COG1475	DNA binding
A4V03_RS01920	COG1192	Involved in chromosome partitioning
A4V03_RS01925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4V03_RS01930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS01960	COG1196	nuclear chromosome segregation
A4V03_RS01965	COG2239	Acts as a magnesium transporter
A4V03_RS01970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V03_RS01980	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS02020	COG0668	transmembrane transport
A4V03_RS02035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4V03_RS02040	COG0713	ATP synthesis coupled electron transport
A4V03_RS02055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4V03_RS02060	COG0649	NAD binding
A4V03_RS02060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V03_RS02080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V03_RS02085	COG0569	domain protein
A4V03_RS02090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V03_RS02105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V03_RS02110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4V03_RS02115	COG0805	protein transport
A4V03_RS02125	COG2271	Major facilitator Superfamily
A4V03_RS02130	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V03_RS02135	COG3775	system Galactitol-specific IIC component
A4V03_RS02150	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02160	COG3292	Two component regulator propeller
A4V03_RS02160	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02160	COG2205	protein histidine kinase activity
A4V03_RS02170	COG0702	epimerase
A4V03_RS02175	COG4771	TonB-dependent receptor
A4V03_RS02195	COG3279	Response regulator of the LytR AlgR family
A4V03_RS02200	COG1242	4 iron, 4 sulfur cluster binding
A4V03_RS02210	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS02215	COG0009	L-threonylcarbamoyladenylate synthase
A4V03_RS02225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS02230	COG0561	phosphatase activity
A4V03_RS02235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V03_RS02270	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02280	COG1874	Beta-galactosidase
A4V03_RS02285	COG0702	epimerase
A4V03_RS02290	COG1629	transport
A4V03_RS02310	COG4771	TonB-dependent receptor
A4V03_RS02320	COG1629	transport
A4V03_RS02330	COG3401	FG-GAP repeat protein
A4V03_RS02345	COG2755	lipolytic protein G-D-S-L family
A4V03_RS02355	COG3401	FG-GAP repeat protein
A4V03_RS02365	COG3254	rhamnose metabolic process
A4V03_RS02375	COG2205	protein histidine kinase activity
A4V03_RS02375	COG3292	Two component regulator propeller
A4V03_RS02375	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02375	COG2205	protein histidine kinase activity
A4V03_RS02375	COG3292	Two component regulator propeller
A4V03_RS02375	COG0745	RESPONSE REGULATOR receiver
A4V03_RS02380	COG3401	FG-GAP repeat protein
A4V03_RS02465	COG4974	Belongs to the 'phage' integrase family
A4V03_RS02515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4V03_RS02535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4V03_RS02540	COG1506	peptidase
A4V03_RS02540	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS02545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V03_RS02560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V03_RS02560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4V03_RS02565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS02570	COG1078	dGTPase activity
A4V03_RS02575	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V03_RS02580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V03_RS02590	COG1704	LemA family
A4V03_RS02605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V03_RS02610	COG2226	methyltransferase
A4V03_RS02615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V03_RS02620	COG1702	phosphate starvation-inducible protein PhoH
A4V03_RS02645	COG2268	Band 7 protein
A4V03_RS02655	COG0101	tRNA pseudouridine synthase activity
A4V03_RS02675	COG3250	beta-galactosidase activity
A4V03_RS02680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V03_RS02685	COG0673	inositol 2-dehydrogenase activity
A4V03_RS02700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4V03_RS02710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS02720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4V03_RS02725	COG0793	Belongs to the peptidase S41A family
A4V03_RS02730	COG2131	deaminase
A4V03_RS02740	COG0339	signal peptide processing
A4V03_RS02750	COG1970	mechanosensitive ion channel activity
A4V03_RS02760	COG1376	ErfK ybiS ycfS ynhG family protein
A4V03_RS02770	COG0443	Heat shock 70 kDa protein
A4V03_RS02785	COG0519	Catalyzes the synthesis of GMP from XMP
A4V03_RS02785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4V03_RS02815	COG4206	TonB-dependent receptor
A4V03_RS02815	COG1629	transport
A4V03_RS02840	COG0793	Belongs to the peptidase S41A family
A4V03_RS02845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS02860	COG0297	glycogen (starch) synthase activity
A4V03_RS02875	COG0297	glycogen (starch) synthase activity
A4V03_RS02880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4V03_RS02885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4V03_RS02890	COG0543	2 iron, 2 sulfur cluster binding
A4V03_RS02895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V03_RS02900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V03_RS02905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4V03_RS02910	COG0791	NLP P60 protein
A4V03_RS02925	COG0612	Peptidase, M16
A4V03_RS02930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4V03_RS02935	COG1597	lipid kinase activity
A4V03_RS02940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V03_RS02955	COG1136	(ABC) transporter
A4V03_RS02975	COG2211	Major facilitator Superfamily
A4V03_RS02985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V03_RS03000	COG1674	ftsk spoiiie
A4V03_RS03010	COG0492	ferredoxin-NADP+ reductase activity
A4V03_RS03050	COG4206	TonB-dependent receptor
A4V03_RS03050	COG1629	transport
A4V03_RS03085	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4V03_RS03085	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4V03_RS03095	COG1234	tRNA 3'-trailer cleavage
A4V03_RS03100	COG2989	Protein conserved in bacteria
A4V03_RS03120	COG3956	TIGRFAM MazG family protein
A4V03_RS03135	COG0525	valine-tRNA ligase activity
A4V03_RS03150	COG0653	protein targeting
A4V03_RS03155	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A4V03_RS03165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V03_RS03185	COG1253	flavin adenine dinucleotide binding
A4V03_RS03195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V03_RS03205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4V03_RS03210	COG2204	response regulator
A4V03_RS03250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V03_RS03250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V03_RS03255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4V03_RS03260	COG0563	adenylate kinase activity
A4V03_RS03265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V03_RS03280	COG0739	heme binding
A4V03_RS03325	COG3142	Participates in the control of copper homeostasis
A4V03_RS03330	COG1418	mRNA catabolic process
A4V03_RS03365	COG1070	Carbohydrate kinase
A4V03_RS03370	COG1063	alcohol dehydrogenase
A4V03_RS03375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4V03_RS03400	COG1333	cytochrome c biogenesis protein
A4V03_RS03400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V03_RS03415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V03_RS03420	COG2832	Protein of unknown function (DUF454)
A4V03_RS03430	COG0602	queuosine metabolic process
A4V03_RS03445	COG0351	phosphomethylpyrimidine kinase
A4V03_RS03460	COG2304	oxidoreductase activity
A4V03_RS03470	COG1393	Belongs to the ArsC family
A4V03_RS03510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V03_RS03515	COG1388	LysM domain
A4V03_RS03515	COG0741	lytic transglycosylase activity
A4V03_RS03605	COG0358	DNA primase activity
A4V03_RS03655	COG3344	reverse transcriptase
A4V03_RS03735	COG0784	Response regulator, receiver
A4V03_RS03735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS03735	COG2198	Histidine kinase
A4V03_RS03735	COG2205	protein histidine kinase activity
A4V03_RS03875	COG4974	Belongs to the 'phage' integrase family
A4V03_RS03880	COG1309	transcriptional regulator
A4V03_RS03890	COG3344	reverse transcriptase
A4V03_RS03910	COG4974	Belongs to the 'phage' integrase family
A4V03_RS03935	COG0551	DNA topoisomerase type I activity
A4V03_RS03935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V03_RS03975	COG0534	Mate efflux family protein
A4V03_RS03980	COG0564	pseudouridine synthase activity
A4V03_RS04000	COG0346	lactoylglutathione lyase activity
A4V03_RS04035	COG0582	viral genome integration into host DNA
A4V03_RS04050	COG3177	Filamentation induced by cAMP protein fic
A4V03_RS04080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4V03_RS04230	COG1910	domain protein
A4V03_RS04255	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V03_RS04285	COG4864	UPF0365 protein
A4V03_RS04300	COG0037	tRNA processing
A4V03_RS04325	COG1477	protein flavinylation
A4V03_RS04330	COG1971	Probably functions as a manganese efflux pump
A4V03_RS04345	COG0463	Glycosyl transferase, family 2
A4V03_RS04370	COG1895	HEPN domain
A4V03_RS04385	COG0148	phosphopyruvate hydratase activity
A4V03_RS04410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4V03_RS04415	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS04420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V03_RS04425	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS04430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4V03_RS04435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V03_RS04435	COG4651	solute:proton antiporter activity
A4V03_RS04445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V03_RS04450	COG0193	aminoacyl-tRNA hydrolase activity
A4V03_RS04455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4V03_RS04465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V03_RS04470	COG1862	Preprotein translocase
A4V03_RS04480	COG0237	dephospho-CoA kinase activity
A4V03_RS04490	COG0542	response to heat
A4V03_RS04505	COG0583	DNA-binding transcription factor activity
A4V03_RS04550	COG0514	ATP-dependent DNA helicase (RecQ)
A4V03_RS04570	COG2855	membrane
A4V03_RS04575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V03_RS04580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4V03_RS04600	COG0443	Heat shock 70 kDa protein
A4V03_RS04670	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04680	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4V03_RS04790	COG1940	carbohydrate kinase activity
A4V03_RS04800	COG3119	arylsulfatase activity
A4V03_RS04810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS04815	COG0702	epimerase
A4V03_RS04820	COG4771	TonB-dependent receptor
A4V03_RS04830	COG5434	Belongs to the glycosyl hydrolase 28 family
A4V03_RS04835	COG0745	RESPONSE REGULATOR receiver
A4V03_RS04835	COG2205	protein histidine kinase activity
A4V03_RS04835	COG3292	Two component regulator propeller
A4V03_RS04840	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4V03_RS04845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V03_RS04855	COG3250	beta-galactosidase activity
A4V03_RS04875	COG0641	radical SAM
A4V03_RS04885	COG4974	Belongs to the 'phage' integrase family
A4V03_RS04905	COG4372	Transposase
A4V03_RS04940	COG5433	transposase activity
A4V03_RS05025	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05045	COG3344	reverse transcriptase
A4V03_RS05055	COG1475	DNA binding
A4V03_RS05175	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4V03_RS05180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS05250	COG0739	heme binding
A4V03_RS05260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS05270	COG1484	DNA-dependent DNA replication
A4V03_RS05275	COG4584	PFAM Integrase catalytic
A4V03_RS05320	COG4372	Transposase
A4V03_RS05375	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05395	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05400	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05405	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05475	COG4584	PFAM Integrase catalytic
A4V03_RS05480	COG1484	DNA-dependent DNA replication
A4V03_RS05490	COG1760	l-serine dehydratase
A4V03_RS05495	COG1193	negative regulation of DNA recombination
A4V03_RS05505	COG4335	DNA alkylation repair
A4V03_RS05540	COG4804	nuclease activity
A4V03_RS05550	COG4974	Belongs to the 'phage' integrase family
A4V03_RS05585	COG1484	DNA-dependent DNA replication
A4V03_RS05590	COG4584	PFAM Integrase catalytic
A4V03_RS05600	COG3344	reverse transcriptase
A4V03_RS05630	COG4372	Transposase
A4V03_RS05665	COG4584	PFAM Integrase catalytic
A4V03_RS05670	COG1484	DNA-dependent DNA replication
A4V03_RS05705	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A4V03_RS05715	COG0561	phosphatase activity
A4V03_RS05720	COG1169	isochorismate synthase
A4V03_RS05725	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4V03_RS05730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4V03_RS05735	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS05755	COG0662	Cupin 2, conserved barrel domain protein
A4V03_RS05755	COG2207	Transcriptional regulator
A4V03_RS05760	COG1082	Xylose isomerase domain protein TIM barrel
A4V03_RS05770	COG2267	carboxylic ester hydrolase activity
A4V03_RS05800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS05810	COG1253	flavin adenine dinucleotide binding
A4V03_RS05815	COG0501	Belongs to the peptidase M48B family
A4V03_RS05835	COG0482	sulfurtransferase activity
A4V03_RS05850	COG2197	response regulator
A4V03_RS05870	COG2814	Major facilitator Superfamily
A4V03_RS05875	COG4953	penicillin-binding protein 1C
A4V03_RS05880	COG2373	Large extracellular alpha-helical protein
A4V03_RS05885	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS05925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V03_RS05930	COG1410	methionine synthase
A4V03_RS05930	COG0646	methionine synthase
A4V03_RS05935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4V03_RS05940	COG0572	uridine kinase
A4V03_RS05950	COG4232	protein-disulfide reductase activity
A4V03_RS05975	COG4771	TonB-dependent receptor
A4V03_RS05980	COG0702	epimerase
A4V03_RS06005	COG2271	Major facilitator Superfamily
A4V03_RS06025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V03_RS06030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V03_RS06035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V03_RS06040	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V03_RS06050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V03_RS06050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4V03_RS06060	COG1773	rubredoxin
A4V03_RS06060	COG1592	Rubrerythrin
A4V03_RS06075	COG3118	belongs to the thioredoxin family
A4V03_RS06080	COG3591	Belongs to the peptidase S1B family
A4V03_RS06085	COG3591	Belongs to the peptidase S1B family
A4V03_RS06090	COG0641	radical SAM
A4V03_RS06105	COG4974	Belongs to the 'phage' integrase family
A4V03_RS06145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V03_RS06145	COG0551	DNA topoisomerase type I activity
A4V03_RS06170	COG0582	viral genome integration into host DNA
A4V03_RS06190	COG0784	Response regulator, receiver
A4V03_RS06190	COG2198	Histidine kinase
A4V03_RS06190	COG2205	protein histidine kinase activity
A4V03_RS06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS06330	COG0358	DNA primase activity
A4V03_RS06405	COG0420	3'-5' exonuclease activity
A4V03_RS06425	COG0646	methionine synthase
A4V03_RS06425	COG1410	methionine synthase
A4V03_RS06430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V03_RS06435	COG0463	Glycosyl transferase, family 2
A4V03_RS06440	COG5433	transposase activity
A4V03_RS06445	COG5433	transposase activity
A4V03_RS06460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V03_RS06465	COG1032	radical SAM domain protein
A4V03_RS06485	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS06490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V03_RS06505	COG1131	(ABC) transporter
A4V03_RS06540	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS06565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V03_RS06575	COG3757	hydrolase, family 25
A4V03_RS06580	COG2264	protein methyltransferase activity
A4V03_RS06595	COG0590	tRNA wobble adenosine to inosine editing
A4V03_RS06600	COG0673	inositol 2-dehydrogenase activity
A4V03_RS06655	COG0698	ribose 5-phosphate isomerase
A4V03_RS06660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V03_RS06675	COG1070	Carbohydrate kinase
A4V03_RS06680	COG2160	L-arabinose isomerase activity
A4V03_RS06720	COG4771	TonB-dependent receptor
A4V03_RS06725	COG2205	protein histidine kinase activity
A4V03_RS06725	COG0745	RESPONSE REGULATOR receiver
A4V03_RS06725	COG3292	Two component regulator propeller
A4V03_RS06730	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS06745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V03_RS06760	COG1482	cell wall glycoprotein biosynthetic process
A4V03_RS06785	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4V03_RS06790	COG3273	potassium ion transport
A4V03_RS06790	COG0471	metal ion transport
A4V03_RS06795	COG0529	Catalyzes the synthesis of activated sulfate
A4V03_RS06800	COG0175	sulfate reduction
A4V03_RS06805	COG2895	sulfate adenylyltransferase (ATP) activity
A4V03_RS06825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4V03_RS06830	COG0242	peptide deformylase activity
A4V03_RS06840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V03_RS06845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4V03_RS06850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4V03_RS06855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4V03_RS06865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V03_RS06870	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V03_RS06875	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS06875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V03_RS06875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V03_RS06875	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS06885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4V03_RS06895	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V03_RS06910	COG1940	carbohydrate kinase activity
A4V03_RS06925	COG2814	Major facilitator Superfamily
A4V03_RS06935	COG4771	TonB-dependent receptor
A4V03_RS07010	COG1629	transport
A4V03_RS07025	COG2814	Major facilitator Superfamily
A4V03_RS07025	COG0477	Major facilitator Superfamily
A4V03_RS07040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS07045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4V03_RS07055	COG0484	heat shock protein binding
A4V03_RS07060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V03_RS07070	COG0488	(ABC) transporter
A4V03_RS07100	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS07115	COG2183	response to ionizing radiation
A4V03_RS07145	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4V03_RS07160	COG0490	domain, Protein
A4V03_RS07160	COG2985	domain, Protein
A4V03_RS07165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A4V03_RS07175	COG1022	Amp-dependent synthetase and ligase
A4V03_RS07180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V03_RS07185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4V03_RS07195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4V03_RS07200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4V03_RS07205	COG0363	glucosamine-6-phosphate deaminase activity
A4V03_RS07225	COG1136	(ABC) transporter
A4V03_RS07225	COG0577	efflux transmembrane transporter activity
A4V03_RS07230	COG1136	(ABC) transporter
A4V03_RS07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS07260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V03_RS07265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V03_RS07300	COG2885	chlorophyll binding
A4V03_RS07305	COG2755	lipolytic protein G-D-S-L family
A4V03_RS07305	COG0657	acetylesterase activity
A4V03_RS07315	COG0488	(ABC) transporter
A4V03_RS07345	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS07370	COG1805	sodium ion transport
A4V03_RS07375	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4V03_RS07390	COG2871	sodium ion transport
A4V03_RS07395	COG0513	Belongs to the DEAD box helicase family
A4V03_RS07405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4V03_RS07420	COG1739	Uncharacterized protein family UPF0029
A4V03_RS07435	COG0778	Nitroreductase
A4V03_RS07450	COG4372	Transposase
A4V03_RS07465	COG4372	Transposase
A4V03_RS07470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V03_RS07470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4V03_RS07475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V03_RS07480	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V03_RS07505	COG2217	Heavy metal translocating P-type atpase
A4V03_RS07515	COG0321	lipoyl(octanoyl) transferase activity
A4V03_RS07525	COG2755	lipolytic protein G-D-S-L family
A4V03_RS07525	COG0657	acetylesterase activity
A4V03_RS07545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V03_RS07555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V03_RS07570	COG1678	Uncharacterized ACR, COG1678
A4V03_RS07630	COG4804	nuclease activity
A4V03_RS07645	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07650	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07655	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07800	COG1475	DNA binding
A4V03_RS07805	COG4474	Belongs to the UPF0398 family
A4V03_RS07855	COG4974	Belongs to the 'phage' integrase family
A4V03_RS07880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4V03_RS08035	COG1475	DNA binding
A4V03_RS08050	COG1192	Involved in chromosome partitioning
A4V03_RS08085	COG0741	lytic transglycosylase activity
A4V03_RS08085	COG1196	nuclear chromosome segregation
A4V03_RS08085	COG0739	heme binding
A4V03_RS08145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS08190	COG4886	Leucine-rich repeat (LRR) protein
A4V03_RS08190	COG4932	domain protein
A4V03_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V03_RS08225	COG1120	ATPase activity
A4V03_RS08330	COG3969	phosphoadenosine phosphosulfate
A4V03_RS08335	COG1475	DNA binding
A4V03_RS08355	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V03_RS08360	COG3537	Alpha-1,2-mannosidase
A4V03_RS08385	COG1629	transport
A4V03_RS08385	COG4206	TonB-dependent receptor
A4V03_RS08410	COG2966	Psort location CytoplasmicMembrane, score
A4V03_RS08445	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08445	COG2205	protein histidine kinase activity
A4V03_RS08445	COG2205	protein histidine kinase activity
A4V03_RS08445	COG3292	Two component regulator propeller
A4V03_RS08445	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08445	COG3292	Two component regulator propeller
A4V03_RS08470	COG0442	prolyl-tRNA aminoacylation
A4V03_RS08475	COG0745	RESPONSE REGULATOR receiver
A4V03_RS08480	COG5002	protein histidine kinase activity
A4V03_RS08500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V03_RS08510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V03_RS08515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4V03_RS08525	COG0552	protein localization to endoplasmic reticulum
A4V03_RS08530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS08545	COG0714	Associated with various cellular activities
A4V03_RS08560	COG2304	oxidoreductase activity
A4V03_RS08605	COG4372	Transposase
A4V03_RS08625	COG0542	response to heat
A4V03_RS08630	COG0326	Molecular chaperone. Has ATPase activity
A4V03_RS08635	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS08670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V03_RS08675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V03_RS08680	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V03_RS08685	COG0167	dihydroorotate dehydrogenase activity
A4V03_RS08690	COG0543	2 iron, 2 sulfur cluster binding
A4V03_RS08705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V03_RS08720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4V03_RS08745	COG1132	(ABC) transporter
A4V03_RS08800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V03_RS08805	COG1597	lipid kinase activity
A4V03_RS08810	COG0156	8-amino-7-oxononanoate synthase activity
A4V03_RS08845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4V03_RS08850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V03_RS08880	COG3830	Belongs to the UPF0237 family
A4V03_RS08880	COG0560	Phosphoserine phosphatase
A4V03_RS08885	COG0513	Belongs to the DEAD box helicase family
A4V03_RS08930	COG4372	Transposase
A4V03_RS08980	COG0246	Mannitol dehydrogenase
A4V03_RS08985	COG1609	Transcriptional regulator
A4V03_RS08990	COG1904	glucuronate isomerase
A4V03_RS09015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V03_RS09050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V03_RS09065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4V03_RS09075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V03_RS09080	COG0477	Major facilitator Superfamily
A4V03_RS09080	COG2814	Major facilitator Superfamily
A4V03_RS09085	COG2115	Belongs to the xylose isomerase family
A4V03_RS09100	COG0351	phosphomethylpyrimidine kinase
A4V03_RS09105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V03_RS09110	COG0724	RNA recognition motif
A4V03_RS09125	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V03_RS09145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V03_RS09160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V03_RS09190	COG2205	protein histidine kinase activity
A4V03_RS09195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V03_RS09210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4V03_RS09220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4V03_RS09240	COG4372	Transposase
A4V03_RS09260	COG3475	LICD family
A4V03_RS09275	COG1216	Glycosyl transferase, family 2
A4V03_RS09315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V03_RS09340	COG4974	Belongs to the 'phage' integrase family
A4V03_RS09360	COG0540	Belongs to the ATCase OTCase family
A4V03_RS09365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A4V03_RS09380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4V03_RS09385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V03_RS09390	COG2985	domain, Protein
A4V03_RS09405	COG2207	Transcriptional regulator
A4V03_RS09415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V03_RS09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V03_RS09425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V03_RS09430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4V03_RS09435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V03_RS09440	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V03_RS09450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V03_RS09455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V03_RS09460	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A4V03_RS09465	COG0454	-acetyltransferase
A4V03_RS09490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V03_RS09500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V03_RS09505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V03_RS09530	COG2233	PERMEase
A4V03_RS09535	COG3263	regulation of cellular component size
A4V03_RS09540	COG1022	Amp-dependent synthetase and ligase
A4V03_RS09645	COG0681	Belongs to the peptidase S26 family
A4V03_RS09725	COG0210	DNA helicase
A4V03_RS09745	COG0352	thiamine-phosphate diphosphorylase activity
A4V03_RS09750	COG2022	thiamine diphosphate biosynthetic process
A4V03_RS09755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4V03_RS09765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V03_RS09770	COG0352	thiamine-phosphate diphosphorylase activity
A4V03_RS09810	COG0358	DNA primase activity
A4V03_RS09810	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS09835	COG1484	DNA-dependent DNA replication
A4V03_RS09840	COG4584	PFAM Integrase catalytic
A4V03_RS09845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V03_RS09845	COG0574	Belongs to the PEP-utilizing enzyme family
A4V03_RS09850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V03_RS09855	COG0564	pseudouridine synthase activity
A4V03_RS09875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V03_RS09905	COG4372	Transposase
A4V03_RS09910	COG0714	Associated with various cellular activities
A4V03_RS09940	COG3339	Conserved Protein
A4V03_RS09995	COG0024	Methionine aminopeptidase
A4V03_RS10005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4V03_RS10010	COG0481	GTPase activity
A4V03_RS10025	COG0432	Pfam Uncharacterised protein family UPF0047
A4V03_RS10040	COG0217	transcriptional regulatory protein
A4V03_RS10045	COG0072	phenylalanine-tRNA ligase activity
A4V03_RS10045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS10050	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS10055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V03_RS10060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V03_RS10065	COG4657	Part of a membrane complex involved in electron transport
A4V03_RS10070	COG4660	Part of a membrane complex involved in electron transport
A4V03_RS10075	COG4659	FMN binding
A4V03_RS10080	COG4658	electron transport chain
A4V03_RS10085	COG4656	Part of a membrane complex involved in electron transport
A4V03_RS10195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V03_RS10210	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS10220	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS10225	COG3475	LICD family
A4V03_RS10235	COG2244	polysaccharide biosynthetic process
A4V03_RS10250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V03_RS10275	COG0504	CTP synthase activity
A4V03_RS10280	COG0706	membrane insertase activity
A4V03_RS10285	COG0534	Mate efflux family protein
A4V03_RS10290	COG1506	peptidase
A4V03_RS10290	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS10295	COG1983	PspC domain protein
A4V03_RS10315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V03_RS10325	COG3942	CHAP domain
A4V03_RS10325	COG1388	LysM domain
A4V03_RS10355	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V03_RS10360	COG0556	nucleotide-excision repair
A4V03_RS10370	COG2949	membrane
A4V03_RS10380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V03_RS10405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V03_RS10410	COG0505	Belongs to the CarA family
A4V03_RS10420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4V03_RS10425	COG0067	glutamate synthase
A4V03_RS10425	COG0070	glutamate synthase
A4V03_RS10425	COG0069	glutamate synthase activity
A4V03_RS10435	COG0367	asparagine synthase
A4V03_RS10445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V03_RS10450	COG0436	Aminotransferase
A4V03_RS10460	COG0347	Belongs to the P(II) protein family
A4V03_RS10465	COG0004	ammonium transporteR
A4V03_RS10490	COG0133	tryptophan synthase activity
A4V03_RS10495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4V03_RS10505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4V03_RS10510	COG0134	indole-3-glycerol-phosphate synthase activity
A4V03_RS10515	COG0135	phosphoribosylanthranilate isomerase activity
A4V03_RS10520	COG0159	tryptophan synthase activity
A4V03_RS10525	COG0252	asparaginase activity
A4V03_RS10535	COG2197	response regulator
A4V03_RS10545	COG0138	bifunctional purine biosynthesis protein purh
A4V03_RS10555	COG4771	TonB-dependent receptor
A4V03_RS10565	COG2985	domain, Protein
A4V03_RS10565	COG0490	domain, Protein
A4V03_RS10585	COG1609	Transcriptional regulator
A4V03_RS10590	COG2721	sulfolactate sulfo-lyase activity
A4V03_RS10635	COG0681	Belongs to the peptidase S26 family
A4V03_RS10725	COG4452	Inner membrane protein CreD
A4V03_RS10740	COG0228	four-way junction DNA binding
A4V03_RS10765	COG0738	Major facilitator superfamily
A4V03_RS10785	COG1177	transmembrane transport
A4V03_RS10790	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V03_RS10795	COG3842	ATPase activity
A4V03_RS10800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS10805	COG0058	SHG alpha-glucan phosphorylase activity
A4V03_RS10820	COG1269	ATP hydrolysis coupled proton transport
A4V03_RS10835	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V03_RS10905	COG4974	Belongs to the 'phage' integrase family
A4V03_RS10960	COG4804	nuclease activity
A4V03_RS11005	COG1882	Formate acetyltransferase
A4V03_RS11010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V03_RS11015	COG2271	Major facilitator Superfamily
A4V03_RS11030	COG1629	transport
A4V03_RS11030	COG4206	TonB-dependent receptor
A4V03_RS11045	COG1595	DNA-templated transcription, initiation
A4V03_RS11065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4V03_RS11070	COG0583	DNA-binding transcription factor activity
A4V03_RS11075	COG0783	Belongs to the Dps family
A4V03_RS11080	COG0668	transmembrane transport
A4V03_RS11100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V03_RS11105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V03_RS11120	COG1295	ribonuclease BN
A4V03_RS11125	COG4372	Transposase
A4V03_RS11140	COG0778	Nitroreductase
A4V03_RS11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V03_RS11160	COG0586	Pfam SNARE associated Golgi protein
A4V03_RS11165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4V03_RS11175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V03_RS11180	COG0167	dihydroorotate dehydrogenase activity
A4V03_RS11185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4V03_RS11245	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS11250	COG5039	Polysaccharide pyruvyl transferase
A4V03_RS11265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V03_RS11295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V03_RS11300	COG0497	DNA recombination
A4V03_RS11315	COG0592	DNA-directed DNA polymerase activity
A4V03_RS11335	COG0321	lipoyl(octanoyl) transferase activity
A4V03_RS11335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V03_RS11340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4V03_RS11350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V03_RS11355	COG0156	8-amino-7-oxononanoate synthase activity
A4V03_RS11370	COG0019	diaminopimelate decarboxylase activity
A4V03_RS11375	COG0527	aspartate kinase activity
A4V03_RS11380	COG2884	Cell division ATP-binding protein ftsE
A4V03_RS11385	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V03_RS11385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V03_RS11390	COG0107	imidazoleglycerol-phosphate synthase activity
A4V03_RS11395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4V03_RS11400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V03_RS11405	COG0788	formyltetrahydrofolate deformylase activity
A4V03_RS11425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V03_RS11440	COG3831	ATPase activity
A4V03_RS11440	COG4884	unkown
A4V03_RS11485	COG3546	catalase activity
A4V03_RS11515	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS11515	COG4946	Tricorn protease homolog
A4V03_RS11515	COG1506	peptidase
A4V03_RS11520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4V03_RS11555	COG1312	Catalyzes the dehydration of D-mannonate
A4V03_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS11565	COG1609	Transcriptional regulator
A4V03_RS11575	COG2223	nitrite transmembrane transporter activity
A4V03_RS11585	COG5433	transposase activity
A4V03_RS11595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V03_RS11595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4V03_RS11610	COG2226	methyltransferase
A4V03_RS11630	COG1690	Belongs to the RtcB family
A4V03_RS11655	COG0702	epimerase
A4V03_RS11660	COG4771	TonB-dependent receptor
A4V03_RS11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V03_RS11695	COG0628	permease
A4V03_RS11700	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS11705	COG0577	efflux transmembrane transporter activity
A4V03_RS11705	COG1136	(ABC) transporter
A4V03_RS11710	COG0436	Aminotransferase
A4V03_RS11740	COG0488	(ABC) transporter
A4V03_RS11760	COG4206	TonB-dependent receptor
A4V03_RS11785	COG0629	single-stranded DNA binding
A4V03_RS11790	COG1194	a g-specific adenine glycosylase
A4V03_RS11805	COG1530	ribonuclease E activity
A4V03_RS11820	COG4191	Histidine kinase
A4V03_RS11825	COG2204	response regulator
A4V03_RS11845	COG1136	(ABC) transporter
A4V03_RS11845	COG0577	efflux transmembrane transporter activity
A4V03_RS11855	COG1136	(ABC) transporter
A4V03_RS11865	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4V03_RS11870	COG0295	cytidine deaminase activity
A4V03_RS11880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V03_RS11885	COG0488	(ABC) transporter
A4V03_RS11895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V03_RS11915	COG1629	transport
A4V03_RS11915	COG4206	TonB-dependent receptor
A4V03_RS11925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS11930	COG0562	UDP-galactopyranose mutase
A4V03_RS11935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS11945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V03_RS11960	COG0463	Glycosyl transferase, family 2
A4V03_RS11960	COG1216	Glycosyl transferase, family 2
A4V03_RS12000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V03_RS12005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4V03_RS12010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4V03_RS12040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V03_RS12060	COG0346	lactoylglutathione lyase activity
A4V03_RS12130	COG0305	Participates in initiation and elongation during chromosome replication
A4V03_RS12195	COG3177	Filamentation induced by cAMP protein fic
A4V03_RS12205	COG1396	sequence-specific DNA binding
A4V03_RS12220	COG1396	sequence-specific DNA binding
A4V03_RS12225	COG4584	PFAM Integrase catalytic
A4V03_RS12230	COG1484	DNA-dependent DNA replication
A4V03_RS12240	COG1309	transcriptional regulator
A4V03_RS12255	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12335	COG1484	DNA-dependent DNA replication
A4V03_RS12340	COG4584	PFAM Integrase catalytic
A4V03_RS12360	COG1918	ferrous iron import across plasma membrane
A4V03_RS12360	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V03_RS12365	COG0037	tRNA processing
A4V03_RS12380	COG3119	arylsulfatase activity
A4V03_RS12385	COG0534	Mate efflux family protein
A4V03_RS12390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V03_RS12395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V03_RS12420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V03_RS12445	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V03_RS12460	COG0668	transmembrane transport
A4V03_RS12465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4V03_RS12475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4V03_RS12485	COG4372	Transposase
A4V03_RS12510	COG1119	ATPase activity
A4V03_RS12515	COG3661	Belongs to the glycosyl hydrolase 67 family
A4V03_RS12530	COG2211	Major facilitator Superfamily
A4V03_RS12540	COG1523	belongs to the glycosyl hydrolase 13 family
A4V03_RS12545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4V03_RS12590	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12630	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12635	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12640	COG4974	Belongs to the 'phage' integrase family
A4V03_RS12650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4V03_RS12655	COG2814	Major facilitator Superfamily
A4V03_RS12660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V03_RS12665	COG0126	phosphoglycerate kinase activity
A4V03_RS12685	COG2311	Membrane
A4V03_RS12695	COG0424	maF-like protein
A4V03_RS12715	COG0778	Nitroreductase
A4V03_RS12725	COG0288	reversible hydration of carbon dioxide
A4V03_RS12740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V03_RS12750	COG0511	ligase activity, forming carbon-carbon bonds
A4V03_RS12755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V03_RS12760	COG0191	fructose-bisphosphate aldolase activity
A4V03_RS12765	COG0254	rRNA binding
A4V03_RS12770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS12785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V03_RS12800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V03_RS12820	COG5002	protein histidine kinase activity
A4V03_RS12825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V03_RS12840	COG1280	lysine exporter protein (LysE YggA)
A4V03_RS12860	COG1649	PFAM Uncharacterised BCR, COG1649
A4V03_RS12880	COG1966	Carbon starvation protein
A4V03_RS12885	COG1649	PFAM Uncharacterised BCR, COG1649
A4V03_RS12910	COG2205	protein histidine kinase activity
A4V03_RS12910	COG3292	Two component regulator propeller
A4V03_RS12910	COG0745	RESPONSE REGULATOR receiver
A4V03_RS12930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4V03_RS12930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V03_RS12940	COG1621	beta-fructofuranosidase activity
A4V03_RS12945	COG0702	epimerase
A4V03_RS12950	COG1629	transport
A4V03_RS12955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V03_RS12965	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V03_RS13010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4V03_RS13015	COG1960	acyl-CoA dehydrogenase activity
A4V03_RS13020	COG1956	GAF domain-containing protein
A4V03_RS13030	COG0484	heat shock protein binding
A4V03_RS13070	COG0459	protein refolding
A4V03_RS13075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V03_RS13090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V03_RS13100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V03_RS13105	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS13105	COG1506	peptidase
A4V03_RS13110	COG0124	histidyl-tRNA synthetase
A4V03_RS13135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V03_RS13170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4V03_RS13175	COG1368	sulfuric ester hydrolase activity
A4V03_RS13180	COG0671	phosphoesterase, PA-phosphatase related
A4V03_RS13185	COG0473	3-isopropylmalate dehydrogenase activity
A4V03_RS13195	COG0066	3-isopropylmalate dehydratase activity
A4V03_RS13200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V03_RS13205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V03_RS13270	COG0714	Associated with various cellular activities
A4V03_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS13290	COG0439	Biotin carboxylase
A4V03_RS13295	COG4770	biotin carboxylase activity
A4V03_RS13300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V03_RS13310	COG2873	o-acetylhomoserine
A4V03_RS13315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V03_RS13325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4V03_RS13330	COG1088	dTDP-glucose 4,6-dehydratase activity
A4V03_RS13335	COG1575	Belongs to the MenA family. Type 1 subfamily
A4V03_RS13345	COG5433	transposase activity
A4V03_RS13355	COG1408	metallophosphoesterase
A4V03_RS13360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V03_RS13370	COG0194	GDP metabolic process
A4V03_RS13390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V03_RS13395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4V03_RS13405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V03_RS13410	COG0750	zinc metalloprotease
A4V03_RS13420	COG1328	CTP reductase activity
A4V03_RS13445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V03_RS13460	COG3550	peptidyl-serine autophosphorylation
A4V03_RS13545	COG1505	serine-type exopeptidase activity
A4V03_RS13560	COG0617	tRNA 3'-terminal CCA addition
A4V03_RS13575	COG0632	four-way junction helicase activity
A4V03_RS13580	COG0673	inositol 2-dehydrogenase activity
A4V03_RS13600	COG4372	Transposase
A4V03_RS13620	COG0488	(ABC) transporter
A4V03_RS13670	COG1595	DNA-templated transcription, initiation
A4V03_RS13685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4V03_RS13695	COG1522	sequence-specific DNA binding
A4V03_RS13725	COG0811	peptide transport
A4V03_RS13735	COG0084	hydrolase, TatD family'
A4V03_RS13755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4V03_RS13760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V03_RS13765	COG0205	6-phosphofructokinase activity
A4V03_RS13800	COG0372	Belongs to the citrate synthase family
A4V03_RS13810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V03_RS13820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V03_RS13835	COG0028	Belongs to the TPP enzyme family
A4V03_RS13840	COG0129	dihydroxy-acid dehydratase activity
A4V03_RS13850	COG3681	Belongs to the UPF0597 family
A4V03_RS13860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4V03_RS13870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V03_RS13875	COG0581	inorganic phosphate transmembrane transporter activity
A4V03_RS13880	COG0573	inorganic phosphate transmembrane transporter activity
A4V03_RS13895	COG1629	transport
A4V03_RS13895	COG4206	TonB-dependent receptor
A4V03_RS13910	COG0745	RESPONSE REGULATOR receiver
A4V03_RS13915	COG5002	protein histidine kinase activity
A4V03_RS13940	COG3250	beta-galactosidase activity
A4V03_RS13950	COG1733	regulation of RNA biosynthetic process
A4V03_RS13965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4V03_RS13970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4V03_RS13980	COG0569	domain protein
A4V03_RS13980	COG2985	domain, Protein
A4V03_RS14025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V03_RS14050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V03_RS14055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V03_RS14060	COG0166	Belongs to the GPI family
A4V03_RS14095	COG2502	aspartate--ammonia ligase
A4V03_RS14100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4V03_RS14115	COG3876	Protein conserved in bacteria
A4V03_RS14125	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS14135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V03_RS14140	COG0778	Nitroreductase
A4V03_RS14150	COG1640	4-alpha-glucanotransferase
A4V03_RS14160	COG1803	Methylglyoxal synthase
A4V03_RS14165	COG1216	Glycosyl transferase, family 2
A4V03_RS14175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS14180	COG1022	Amp-dependent synthetase and ligase
A4V03_RS14215	COG0359	binds to the 23S rRNA
A4V03_RS14220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V03_RS14225	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V03_RS14245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V03_RS14250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V03_RS14285	COG2431	L-lysine efflux transmembrane transporter activity
A4V03_RS14320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4V03_RS14335	COG2234	aminopeptidase activity
A4V03_RS14350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4V03_RS14355	COG0802	atpase or kinase
A4V03_RS14380	COG0714	Associated with various cellular activities
A4V03_RS14415	COG3118	belongs to the thioredoxin family
A4V03_RS14425	COG0688	phosphatidylethanolamine metabolic process
A4V03_RS14430	COG1183	phosphatidylcholine synthase activity
A4V03_RS14450	COG0792	nuclease activity
A4V03_RS14470	COG1595	DNA-templated transcription, initiation
A4V03_RS14485	COG1629	transport
A4V03_RS14490	COG0702	epimerase
A4V03_RS14505	COG3408	Glycogen debranching enzyme
A4V03_RS14510	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS14515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4V03_RS14535	COG0534	Mate efflux family protein
A4V03_RS14540	COG0528	UMP kinase activity
A4V03_RS14550	COG0233	cytoplasmic translational termination
A4V03_RS14555	COG1162	GTPase activity
A4V03_RS14565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V03_RS14580	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V03_RS14580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V03_RS14590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V03_RS14600	COG4206	TonB-dependent receptor
A4V03_RS14600	COG1629	transport
A4V03_RS14620	COG4206	TonB-dependent receptor
A4V03_RS14620	COG1629	transport
A4V03_RS14625	COG5433	transposase activity
A4V03_RS14630	COG4974	Belongs to the 'phage' integrase family
A4V03_RS14635	COG1629	transport
A4V03_RS14635	COG4206	TonB-dependent receptor
A4V03_RS14650	COG2095	MarC family integral membrane protein
A4V03_RS14665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V03_RS14675	COG1435	thymidine kinase activity
A4V03_RS14680	COG0628	permease
A4V03_RS14745	COG0534	Mate efflux family protein
A4V03_RS14755	COG2205	protein histidine kinase activity
A4V03_RS14755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V03_RS14755	COG0784	Response regulator, receiver
A4V03_RS14755	COG2198	Histidine kinase
A4V03_RS14765	COG4372	Transposase
A4V03_RS14820	COG1733	regulation of RNA biosynthetic process
A4V03_RS14830	COG4413	Urea transporter
A4V03_RS14865	COG0589	response to stress
A4V03_RS14865	COG0475	glutathione-regulated potassium exporter activity
A4V03_RS14875	COG1522	sequence-specific DNA binding
A4V03_RS14890	COG0693	protein deglycase activity
A4V03_RS14895	COG0668	transmembrane transport
A4V03_RS14915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4V03_RS14920	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A4V03_RS14925	COG0460	homoserine dehydrogenase
A4V03_RS14925	COG0527	aspartate kinase activity
A4V03_RS14935	COG0252	asparaginase activity
A4V03_RS14940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V03_RS14945	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V03_RS14960	COG4771	TonB-dependent receptor
A4V03_RS14975	COG0826	peptidase U32
A4V03_RS14980	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V03_RS15000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4V03_RS15035	COG4771	TonB-dependent receptor
A4V03_RS15110	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS15140	COG0702	epimerase
A4V03_RS15145	COG4771	TonB-dependent receptor
A4V03_RS15165	COG0471	metal ion transport
A4V03_RS15170	COG2205	protein histidine kinase activity
A4V03_RS15170	COG3292	Two component regulator propeller
A4V03_RS15170	COG2205	protein histidine kinase activity
A4V03_RS15170	COG0745	RESPONSE REGULATOR receiver
A4V03_RS15170	COG3292	Two component regulator propeller
A4V03_RS15170	COG0745	RESPONSE REGULATOR receiver
A4V03_RS15185	COG0616	signal peptide processing
A4V03_RS15190	COG1663	tetraacyldisaccharide 4'-kinase activity
A4V03_RS15195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4V03_RS15200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4V03_RS15220	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS15250	COG1629	transport
A4V03_RS15255	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS15265	COG4948	Mandelate Racemase Muconate Lactonizing
A4V03_RS15270	COG2755	lipolytic protein G-D-S-L family
A4V03_RS15270	COG0657	acetylesterase activity
A4V03_RS15280	COG3940	Belongs to the glycosyl hydrolase 43 family
A4V03_RS15285	COG3250	beta-galactosidase activity
A4V03_RS15305	COG4206	TonB-dependent receptor
A4V03_RS15305	COG1629	transport
A4V03_RS15340	COG2205	protein histidine kinase activity
A4V03_RS15340	COG0745	RESPONSE REGULATOR receiver
A4V03_RS15340	COG3292	Two component regulator propeller
A4V03_RS15355	COG4206	TonB-dependent receptor
A4V03_RS15355	COG1629	transport
A4V03_RS15375	COG5433	transposase activity
A4V03_RS15380	COG0582	viral genome integration into host DNA
A4V03_RS15385	COG4974	Belongs to the 'phage' integrase family
A4V03_RS15410	COG2204	response regulator
A4V03_RS15430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS15440	COG1368	sulfuric ester hydrolase activity
A4V03_RS15600	COG1192	Involved in chromosome partitioning
A4V03_RS15725	COG0484	heat shock protein binding
A4V03_RS15805	COG1404	Belongs to the peptidase S8 family
A4V03_RS15835	COG4206	TonB-dependent receptor
A4V03_RS15835	COG1629	transport
A4V03_RS15840	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V03_RS15860	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS15865	COG0737	Belongs to the 5'-nucleotidase family
A4V03_RS15870	COG0737	Belongs to the 5'-nucleotidase family
A4V03_RS15875	COG0335	large ribosomal subunit rRNA binding
A4V03_RS15890	COG0577	efflux transmembrane transporter activity
A4V03_RS15890	COG1136	(ABC) transporter
A4V03_RS15895	COG0577	efflux transmembrane transporter activity
A4V03_RS15895	COG1136	(ABC) transporter
A4V03_RS15900	COG1136	(ABC) transporter
A4V03_RS15900	COG0577	efflux transmembrane transporter activity
A4V03_RS15925	COG2996	Protein conserved in bacteria
A4V03_RS15930	COG0582	viral genome integration into host DNA
A4V03_RS15950	COG0732	type I restriction modification DNA specificity domain
A4V03_RS15975	COG0039	L-malate dehydrogenase activity
A4V03_RS15985	COG2217	Heavy metal translocating P-type atpase
A4V03_RS15990	COG1373	ATPase (AAA superfamily
A4V03_RS16010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V03_RS16015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V03_RS16020	COG0509	glycine decarboxylation via glycine cleavage system
A4V03_RS16035	COG0006	proline dipeptidase activity
A4V03_RS16050	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4V03_RS16055	COG1773	rubredoxin
A4V03_RS16060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V03_RS16065	COG1011	Hydrolase
A4V03_RS16070	COG0196	riboflavin kinase activity
A4V03_RS16075	COG1266	CAAX protease self-immunity
A4V03_RS16080	COG2166	iron-sulfur cluster assembly
A4V03_RS16085	COG2234	aminopeptidase activity
A4V03_RS16090	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4V03_RS16095	COG0280	phosphate acetyltransferase
A4V03_RS16100	COG3426	butyrate kinase activity
A4V03_RS16105	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V03_RS16115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V03_RS16135	COG2066	Belongs to the glutaminase family
A4V03_RS16220	COG4656	Part of a membrane complex involved in electron transport
A4V03_RS16290	COG0110	maltose O-acetyltransferase activity
A4V03_RS16335	COG4974	Belongs to the 'phage' integrase family
A4V03_RS16340	COG4584	PFAM Integrase catalytic
A4V03_RS16345	COG1484	DNA-dependent DNA replication
A4V03_RS16350	COG5433	transposase activity
A4V03_RS16375	COG3345	alpha-galactosidase
A4V03_RS16440	COG0667	Aldo Keto reductase
A4V03_RS16495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS16505	COG1309	transcriptional regulator
A4V03_RS16510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS16520	COG4771	TonB-dependent receptor
A4V03_RS16550	COG4372	Transposase
A4V03_RS16575	COG0203	ribosomal protein L17
A4V03_RS16580	COG0202	RNA polymerase activity
A4V03_RS16585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V03_RS16590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V03_RS16595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V03_RS16600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V03_RS16605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V03_RS16620	COG0200	Binds to the 23S rRNA
A4V03_RS16625	COG1841	ribosomal large subunit assembly
A4V03_RS16630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V03_RS16635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4V03_RS16640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V03_RS16645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4V03_RS16650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V03_RS16655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4V03_RS16660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4V03_RS16665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4V03_RS16670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V03_RS16675	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V03_RS16680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V03_RS16685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4V03_RS16690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V03_RS16695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4V03_RS16700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V03_RS16705	COG0089	rRNA binding
A4V03_RS16710	COG0088	Forms part of the polypeptide exit tunnel
A4V03_RS16715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V03_RS16720	COG0051	transcription antitermination factor activity, RNA binding
A4V03_RS16725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V03_RS16730	COG0049	tRNA binding
A4V03_RS16735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V03_RS16745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V03_RS16750	COG0085	RNA polymerase activity
A4V03_RS16755	COG0222	ribosome binding
A4V03_RS16760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4V03_RS16765	COG0081	regulation of translation
A4V03_RS16770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4V03_RS16780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V03_RS16790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V03_RS16820	COG4974	Belongs to the 'phage' integrase family
A4V03_RS16825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V03_RS16835	COG0006	proline dipeptidase activity
A4V03_RS16840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4V03_RS16855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V03_RS16865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V03_RS16870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V03_RS16885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V03_RS16890	COG0252	asparaginase activity
A4V03_RS16905	COG2096	Adenosyltransferase
A4V03_RS16950	COG1051	belongs to the nudix hydrolase family
A4V03_RS16955	COG0546	phosphoglycolate phosphatase activity
A4V03_RS16975	COG4974	Belongs to the 'phage' integrase family
A4V03_RS16980	COG4804	nuclease activity
A4V03_RS17085	COG0662	Cupin 2, conserved barrel domain protein
A4V03_RS17085	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A4V03_RS17090	COG0318	PFAM AMP-dependent synthetase and ligase
A4V03_RS17095	COG1396	sequence-specific DNA binding
A4V03_RS17100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V03_RS17120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4V03_RS17125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4V03_RS17170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4V03_RS17175	COG0793	Belongs to the peptidase S41A family
A4V03_RS17195	COG1040	competence protein
A4V03_RS17240	COG2610	gluconate transmembrane transporter activity
A4V03_RS17245	COG1929	Belongs to the glycerate kinase type-1 family
A4V03_RS17265	COG1629	transport
A4V03_RS17270	COG5433	transposase activity
A4V03_RS17275	COG5433	transposase activity
A4V03_RS17290	COG1609	Transcriptional regulator
A4V03_RS17295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS17300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS17305	COG4771	TonB-dependent receptor
A4V03_RS17360	COG0018	arginyl-trna synthetase
A4V03_RS17370	COG0705	Rhomboid family
A4V03_RS17385	COG0339	signal peptide processing
A4V03_RS17390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V03_RS17660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V03_RS17715	COG3723	Recombinational DNA repair protein, rece pathway
A4V03_RS17720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V03_RS17780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V03_RS17780	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS17785	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V03_RS17790	COG1373	ATPase (AAA superfamily
A4V03_RS17795	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4V03_RS17800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V03_RS17820	COG4974	Belongs to the 'phage' integrase family
A4V03_RS17835	COG0606	chelatase, subunit chli
A4V03_RS17840	COG2205	protein histidine kinase activity
A4V03_RS17845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS17865	COG0702	epimerase
A4V03_RS17870	COG4771	TonB-dependent receptor
A4V03_RS17880	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS17885	COG3119	arylsulfatase activity
A4V03_RS17915	COG3250	beta-galactosidase activity
A4V03_RS17935	COG0702	epimerase
A4V03_RS17940	COG4771	TonB-dependent receptor
A4V03_RS17950	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V03_RS17980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4V03_RS17985	COG1629	transport
A4V03_RS17985	COG4206	TonB-dependent receptor
A4V03_RS18000	COG0673	inositol 2-dehydrogenase activity
A4V03_RS18010	COG0673	inositol 2-dehydrogenase activity
A4V03_RS18020	COG3292	Two component regulator propeller
A4V03_RS18020	COG2205	protein histidine kinase activity
A4V03_RS18020	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS18045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V03_RS18060	COG3475	LICD family
A4V03_RS18075	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS18090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V03_RS18095	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS18100	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V03_RS18120	COG0561	phosphatase activity
A4V03_RS18170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4V03_RS18175	COG0793	Belongs to the peptidase S41A family
A4V03_RS18175	COG3409	Peptidoglycan-binding domain 1 protein
A4V03_RS18200	COG0702	epimerase
A4V03_RS18205	COG4206	TonB-dependent receptor
A4V03_RS18205	COG1629	transport
A4V03_RS18210	COG2205	protein histidine kinase activity
A4V03_RS18210	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18210	COG3292	Two component regulator propeller
A4V03_RS18235	COG1053	succinate dehydrogenase
A4V03_RS18240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4V03_RS18265	COG0758	DNA mediated transformation
A4V03_RS18275	COG0826	peptidase U32
A4V03_RS18280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V03_RS18295	COG0557	exoribonuclease II activity
A4V03_RS18305	COG5002	protein histidine kinase activity
A4V03_RS18315	COG1629	transport
A4V03_RS18315	COG4206	TonB-dependent receptor
A4V03_RS18330	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V03_RS18335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4V03_RS18340	COG1917	Cupin 2, conserved barrel domain protein
A4V03_RS18380	COG0702	epimerase
A4V03_RS18385	COG4771	TonB-dependent receptor
A4V03_RS18420	COG3119	arylsulfatase activity
A4V03_RS18420	COG3408	Glycogen debranching enzyme
A4V03_RS18430	COG3292	Two component regulator propeller
A4V03_RS18430	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18430	COG2205	protein histidine kinase activity
A4V03_RS18435	COG5433	transposase activity
A4V03_RS18450	COG4206	TonB-dependent receptor
A4V03_RS18450	COG1629	transport
A4V03_RS18460	COG4206	TonB-dependent receptor
A4V03_RS18460	COG1629	transport
A4V03_RS18485	COG3119	arylsulfatase activity
A4V03_RS18490	COG2814	Major facilitator Superfamily
A4V03_RS18495	COG0012	GTP binding
A4V03_RS18500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4V03_RS18505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4V03_RS18510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V03_RS18520	COG1629	transport
A4V03_RS18560	COG0697	spore germination
A4V03_RS18570	COG3250	beta-galactosidase activity
A4V03_RS18575	COG0495	leucyl-tRNA aminoacylation
A4V03_RS18580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V03_RS18585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V03_RS18590	COG1360	Flagellar Motor Protein
A4V03_RS18595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4V03_RS18630	COG1629	transport
A4V03_RS18630	COG4206	TonB-dependent receptor
A4V03_RS18660	COG0731	radical SAM domain protein
A4V03_RS18660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V03_RS18685	COG0659	secondary active sulfate transmembrane transporter activity
A4V03_RS18690	COG1592	Rubrerythrin
A4V03_RS18700	COG3292	Two component regulator propeller
A4V03_RS18700	COG2205	protein histidine kinase activity
A4V03_RS18700	COG0745	RESPONSE REGULATOR receiver
A4V03_RS18715	COG4771	TonB-dependent receptor
A4V03_RS18730	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V03_RS18755	COG0427	acetyl-CoA hydrolase
A4V03_RS18765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V03_RS18790	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V03_RS18805	COG4372	Transposase
A4V03_RS18835	COG2177	Part of the ABC transporter FtsEX involved in
A4V03_RS18845	COG1968	undecaprenyl-diphosphatase activity
A4V03_RS18850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V03_RS18855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V03_RS18860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4V03_RS18870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V03_RS18890	COG0594	ribonuclease P activity
A4V03_RS18895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4V03_RS18905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4V03_RS18915	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V03_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
A4V03_RS18950	COG4771	TonB-dependent receptor
A4V03_RS18960	COG0726	polysaccharide deacetylase
A4V03_RS18970	COG5433	transposase activity
A4V03_RS18985	COG1121	(ABC) transporter
A4V03_RS18995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V03_RS18995	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4V03_RS19000	COG1238	metal cluster binding
A4V03_RS19015	COG0823	Involved in the tonB-independent uptake of proteins
A4V03_RS19015	COG1506	peptidase
A4V03_RS19025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V03_RS19025	COG0116	Belongs to the methyltransferase superfamily
A4V03_RS19030	COG1045	serine acetyltransferase
A4V03_RS19040	COG3279	Response regulator of the LytR AlgR family
A4V03_RS19055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V03_RS19055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V03_RS19060	COG0142	geranyltranstransferase activity
A4V03_RS19065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4V03_RS19070	COG1694	Mazg nucleotide pyrophosphohydrolase
A4V03_RS19075	COG1490	D-aminoacyl-tRNA deacylase activity
A4V03_RS19085	COG0322	excinuclease ABC activity
A4V03_RS19090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V03_RS19095	COG0445	tRNA wobble uridine modification
A4V03_RS19120	COG3344	reverse transcriptase
A4V03_RS19125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4V03_RS19130	COG2715	membrane protein required for spore maturation
A4V03_RS19135	COG2255	four-way junction helicase activity
A4V03_RS19140	COG2852	Protein conserved in bacteria
A4V03_RS19155	COG3591	Belongs to the peptidase S1B family
A4V03_RS19180	COG0702	epimerase
A4V03_RS19185	COG1629	transport
A4V03_RS19185	COG4206	TonB-dependent receptor
A4V03_RS19195	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19195	COG3292	Two component regulator propeller
A4V03_RS19195	COG2205	protein histidine kinase activity
A4V03_RS19200	COG0513	Belongs to the DEAD box helicase family
A4V03_RS19210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V03_RS19225	COG0612	Peptidase, M16
A4V03_RS19275	COG0681	Belongs to the peptidase S26 family
A4V03_RS19285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V03_RS19335	COG5492	domain, Protein
A4V03_RS19345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V03_RS19355	COG0702	epimerase
A4V03_RS19360	COG4771	TonB-dependent receptor
A4V03_RS19365	COG3119	arylsulfatase activity
A4V03_RS19370	COG3292	Two component regulator propeller
A4V03_RS19370	COG2205	protein histidine kinase activity
A4V03_RS19370	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19370	COG3292	Two component regulator propeller
A4V03_RS19370	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19370	COG2205	protein histidine kinase activity
A4V03_RS19385	COG0702	epimerase
A4V03_RS19390	COG1629	transport
A4V03_RS19400	COG1629	transport
A4V03_RS19420	COG0738	Major facilitator superfamily
A4V03_RS19435	COG1940	carbohydrate kinase activity
A4V03_RS19440	COG3250	beta-galactosidase activity
A4V03_RS19450	COG1609	Transcriptional regulator
A4V03_RS19460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V03_RS19465	COG1538	Outer membrane efflux protein
A4V03_RS19475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V03_RS19480	COG3250	beta-galactosidase activity
A4V03_RS19485	COG4771	TonB-dependent receptor
A4V03_RS19495	COG1629	transport
A4V03_RS19500	COG0702	epimerase
A4V03_RS19535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V03_RS19540	COG3119	arylsulfatase activity
A4V03_RS19545	COG5492	domain, Protein
A4V03_RS19550	COG0215	cysteine-tRNA ligase activity
A4V03_RS19555	COG0561	phosphatase activity
A4V03_RS19575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V03_RS19580	COG0482	sulfurtransferase activity
A4V03_RS19590	COG0205	6-phosphofructokinase activity
A4V03_RS19595	COG0571	ribonuclease III activity
A4V03_RS19600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V03_RS19605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V03_RS19610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V03_RS19615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V03_RS19650	COG0438	transferase activity, transferring glycosyl groups
A4V03_RS19655	COG3475	LICD family
A4V03_RS19660	COG4750	Nucleotidyl transferase
A4V03_RS19670	COG0463	Glycosyl transferase, family 2
A4V03_RS19675	COG0463	Glycosyl transferase, family 2
A4V03_RS19680	COG1216	Glycosyl transferase, family 2
A4V03_RS19695	COG1215	transferase activity, transferring glycosyl groups
A4V03_RS19700	COG1216	Glycosyl transferase, family 2
A4V03_RS19700	COG1442	glycosyl transferase family 8
A4V03_RS19705	COG1216	Glycosyl transferase, family 2
A4V03_RS19755	COG1132	(ABC) transporter
A4V03_RS19760	COG3341	Caulimovirus viroplasmin
A4V03_RS19760	COG0328	RNA-DNA hybrid ribonuclease activity
A4V03_RS19765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V03_RS19775	COG0326	Molecular chaperone. Has ATPase activity
A4V03_RS19785	COG1166	arginine decarboxylase activity
A4V03_RS19790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V03_RS19795	COG1595	DNA-templated transcription, initiation
A4V03_RS19815	COG0779	Required for maturation of 30S ribosomal subunits
A4V03_RS19820	COG0195	Participates in both transcription termination and antitermination
A4V03_RS19825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V03_RS19835	COG0719	Fe-S assembly protein
A4V03_RS19840	COG0396	ATPase activity
A4V03_RS19845	COG0719	Fe-S assembly protein
A4V03_RS19850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4V03_RS19855	COG0393	Putative heavy-metal-binding
A4V03_RS19880	COG2205	protein histidine kinase activity
A4V03_RS19880	COG3292	Two component regulator propeller
A4V03_RS19880	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19880	COG3292	Two component regulator propeller
A4V03_RS19880	COG2205	protein histidine kinase activity
A4V03_RS19880	COG0745	RESPONSE REGULATOR receiver
A4V03_RS19885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V03_RS19930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V03_RS19940	COG0187	DNA topoisomerase II activity
A4V03_RS19945	COG0268	Binds directly to 16S ribosomal RNA
A4V03_RS19955	COG1381	Involved in DNA repair and RecF pathway recombination
A4V03_RS19985	COG5433	transposase activity
A4V03_RS19995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4V03_RS20010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V03_RS20015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V03_RS20020	COG0772	Belongs to the SEDS family
A4V03_RS20025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V03_RS20030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V03_RS20035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V03_RS20050	COG0275	rRNA processing
A4V03_RS20055	COG2001	Belongs to the MraZ family
A4V03_RS20075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V03_RS20080	COG0756	dUTP diphosphatase activity
A4V03_RS20095	COG4942	peptidase
A4V03_RS20100	COG3292	Two component regulator propeller
A4V03_RS20100	COG2205	protein histidine kinase activity
A4V03_RS20100	COG0745	RESPONSE REGULATOR receiver
A4V03_RS20110	COG3119	arylsulfatase activity
A4V03_RS20135	COG4771	TonB-dependent receptor
A4V03_RS20160	COG4771	TonB-dependent receptor
A4V03_RS20170	COG5433	transposase activity
A4V03_RS20175	COG0702	epimerase
A4V03_RS20200	COG4771	TonB-dependent receptor
A4V03_RS20205	COG0702	epimerase
A4V03_RS20260	COG3537	Alpha-1,2-mannosidase
A4V03_RS20265	COG2017	converts alpha-aldose to the beta-anomer
A4V03_RS20435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V03_RS20440	COG1022	Amp-dependent synthetase and ligase
A4V03_RS20460	COG2954	triphosphatase activity
A4V03_RS20520	COG0561	phosphatase activity
A4V03_RS20525	COG4771	TonB-dependent receptor