locus-tag	class	description
K6V21_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6V21_RS00010	COG0778	Nitroreductase
K6V21_RS00020	COG1640	4-alpha-glucanotransferase
K6V21_RS00025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6V21_RS00070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V21_RS00075	COG0318	PFAM AMP-dependent synthetase and ligase
K6V21_RS00095	COG0359	binds to the 23S rRNA
K6V21_RS00100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6V21_RS00105	COG0360	Binds together with S18 to 16S ribosomal RNA
K6V21_RS00130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V21_RS00135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K6V21_RS00160	COG4771	TonB-dependent receptor
K6V21_RS00165	COG3292	Two component regulator propeller
K6V21_RS00165	COG0745	RESPONSE REGULATOR receiver
K6V21_RS00165	COG2205	protein histidine kinase activity
K6V21_RS00175	COG2755	lipolytic protein G-D-S-L family
K6V21_RS00210	COG4771	TonB-dependent receptor
K6V21_RS00215	COG0745	RESPONSE REGULATOR receiver
K6V21_RS00215	COG2205	protein histidine kinase activity
K6V21_RS00215	COG3292	Two component regulator propeller
K6V21_RS00225	COG3250	beta-galactosidase activity
K6V21_RS00240	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS00270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS00275	COG1629	transport
K6V21_RS00290	COG2205	protein histidine kinase activity
K6V21_RS00290	COG3292	Two component regulator propeller
K6V21_RS00290	COG0745	RESPONSE REGULATOR receiver
K6V21_RS00310	COG3291	Pkd domain containing protein
K6V21_RS00310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS00330	COG4771	TonB-dependent receptor
K6V21_RS00340	COG3292	Two component regulator propeller
K6V21_RS00340	COG2205	protein histidine kinase activity
K6V21_RS00340	COG0745	RESPONSE REGULATOR receiver
K6V21_RS00350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V21_RS00415	COG3279	Response regulator of the LytR AlgR family
K6V21_RS00420	COG3275	phosphorelay sensor kinase activity
K6V21_RS00435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V21_RS00445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K6V21_RS00455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V21_RS00465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V21_RS00475	COG3119	arylsulfatase activity
K6V21_RS00485	COG0745	RESPONSE REGULATOR receiver
K6V21_RS00485	COG2205	protein histidine kinase activity
K6V21_RS00485	COG3292	Two component regulator propeller
K6V21_RS00495	COG4771	TonB-dependent receptor
K6V21_RS00500	COG0702	epimerase
K6V21_RS00505	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS00515	COG3119	arylsulfatase activity
K6V21_RS00525	COG1940	carbohydrate kinase activity
K6V21_RS00540	COG3119	arylsulfatase activity
K6V21_RS00540	COG3408	Glycogen debranching enzyme
K6V21_RS00615	COG0681	Belongs to the peptidase S26 family
K6V21_RS00680	COG2333	competence protein COMEC
K6V21_RS00680	COG0658	competence protein
K6V21_RS00685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6V21_RS00700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6V21_RS00710	COG0009	L-threonylcarbamoyladenylate synthase
K6V21_RS00725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6V21_RS00730	COG0542	response to heat
K6V21_RS00735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K6V21_RS00740	COG3022	response to hydroperoxide
K6V21_RS00745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6V21_RS00745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6V21_RS00750	COG0514	ATP-dependent DNA helicase (RecQ)
K6V21_RS00755	COG1115	amino acid carrier protein
K6V21_RS00755	COG1115	amino acid carrier protein
K6V21_RS00760	COG0501	Belongs to the peptidase M48B family
K6V21_RS00775	COG4771	TonB-dependent receptor
K6V21_RS00785	COG3069	C4-dicarboxylate transmembrane transporter activity
K6V21_RS00790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6V21_RS00815	COG3119	arylsulfatase activity
K6V21_RS00825	COG0436	Aminotransferase
K6V21_RS00830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V21_RS00840	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6V21_RS00850	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
K6V21_RS00855	COG0358	DNA primase activity
K6V21_RS00860	COG0302	gtp cyclohydrolase
K6V21_RS00870	COG0149	triose-phosphate isomerase activity
K6V21_RS00885	COG0739	heme binding
K6V21_RS00890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6V21_RS00895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6V21_RS00910	COG0848	biopolymer transport protein
K6V21_RS00915	COG0811	peptide transport
K6V21_RS00920	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6V21_RS00925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6V21_RS00940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V21_RS00950	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V21_RS00960	COG1442	glycosyl transferase family 8
K6V21_RS00960	COG1216	Glycosyl transferase, family 2
K6V21_RS00980	COG3475	LICD family
K6V21_RS00985	COG2244	polysaccharide biosynthetic process
K6V21_RS00995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V21_RS01025	COG1373	ATPase (AAA superfamily
K6V21_RS01030	COG0039	L-malate dehydrogenase activity
K6V21_RS01045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS01060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS01085	COG0489	protein tyrosine kinase activity
K6V21_RS01090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6V21_RS01095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V21_RS01105	COG1570	exodeoxyribonuclease VII activity
K6V21_RS01115	COG0482	sulfurtransferase activity
K6V21_RS01125	COG3250	beta-galactosidase activity
K6V21_RS01140	COG0702	epimerase
K6V21_RS01145	COG1629	transport
K6V21_RS01145	COG4206	TonB-dependent receptor
K6V21_RS01155	COG1785	Belongs to the alkaline phosphatase family
K6V21_RS01160	COG3292	Two component regulator propeller
K6V21_RS01160	COG2205	protein histidine kinase activity
K6V21_RS01160	COG0745	RESPONSE REGULATOR receiver
K6V21_RS01165	COG2382	esterase
K6V21_RS01165	COG3693	PFAM glycoside hydrolase, family 10
K6V21_RS01195	COG0352	thiamine-phosphate diphosphorylase activity
K6V21_RS01200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6V21_RS01205	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
K6V21_RS01210	COG0352	thiamine-phosphate diphosphorylase activity
K6V21_RS01215	COG0351	phosphomethylpyrimidine kinase
K6V21_RS01220	COG0673	inositol 2-dehydrogenase activity
K6V21_RS01230	COG1408	metallophosphoesterase
K6V21_RS01235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6V21_RS01250	COG1629	transport
K6V21_RS01250	COG4206	TonB-dependent receptor
K6V21_RS01305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6V21_RS01310	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6V21_RS01315	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6V21_RS01330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6V21_RS01335	COG0052	Belongs to the universal ribosomal protein uS2 family
K6V21_RS01340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6V21_RS01345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6V21_RS01355	COG0017	Asparaginyl-tRNA synthetase
K6V21_RS01360	COG1187	pseudouridine synthase activity
K6V21_RS01380	COG0110	maltose O-acetyltransferase activity
K6V21_RS01390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V21_RS01415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6V21_RS01430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V21_RS01440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V21_RS01445	COG0516	GMP reductase activity
K6V21_RS01445	COG0517	IMP dehydrogenase activity
K6V21_RS01470	COG4771	TonB-dependent receptor
K6V21_RS01485	COG0514	ATP-dependent DNA helicase (RecQ)
K6V21_RS01490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6V21_RS01495	COG0740	serine-type endopeptidase activity
K6V21_RS01500	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6V21_RS01505	COG0724	RNA recognition motif
K6V21_RS01515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6V21_RS01520	COG1127	ABC transporter
K6V21_RS01530	COG2197	response regulator
K6V21_RS01540	COG1160	GTP binding
K6V21_RS01545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6V21_RS01550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS01565	COG2205	protein histidine kinase activity
K6V21_RS01600	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS01605	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS01610	COG0702	epimerase
K6V21_RS01615	COG4771	TonB-dependent receptor
K6V21_RS01625	COG3292	Two component regulator propeller
K6V21_RS01625	COG2205	protein histidine kinase activity
K6V21_RS01625	COG0745	RESPONSE REGULATOR receiver
K6V21_RS01650	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6V21_RS01665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6V21_RS01670	COG2202	Pas domain
K6V21_RS01670	COG2205	protein histidine kinase activity
K6V21_RS01675	COG2202	Pas domain
K6V21_RS01675	COG2205	protein histidine kinase activity
K6V21_RS01690	COG0436	Aminotransferase
K6V21_RS01695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V21_RS01720	COG1234	tRNA 3'-trailer cleavage
K6V21_RS01725	COG4946	Tricorn protease homolog
K6V21_RS01725	COG0793	Belongs to the peptidase S41A family
K6V21_RS01730	COG3292	Two component regulator propeller
K6V21_RS01730	COG0745	RESPONSE REGULATOR receiver
K6V21_RS01730	COG2205	protein histidine kinase activity
K6V21_RS01765	COG1629	transport
K6V21_RS01765	COG4206	TonB-dependent receptor
K6V21_RS01785	COG4948	Mandelate Racemase Muconate Lactonizing
K6V21_RS01805	COG5002	protein histidine kinase activity
K6V21_RS01810	COG2205	protein histidine kinase activity
K6V21_RS01820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6V21_RS01825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K6V21_RS01830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6V21_RS01840	COG0662	Cupin 2, conserved barrel domain protein
K6V21_RS01840	COG2207	Transcriptional regulator
K6V21_RS01915	COG2204	response regulator
K6V21_RS01920	COG0527	aspartate kinase activity
K6V21_RS01920	COG0460	homoserine dehydrogenase
K6V21_RS01930	COG2942	2-epimerase
K6V21_RS01935	COG2211	Major facilitator Superfamily
K6V21_RS01940	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V21_RS01945	COG4124	Belongs to the glycosyl hydrolase 26 family
K6V21_RS01955	COG4124	Belongs to the glycosyl hydrolase 26 family
K6V21_RS01970	COG0561	phosphatase activity
K6V21_RS01975	COG4771	TonB-dependent receptor
K6V21_RS01980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6V21_RS01990	COG3458	cephalosporin-C deacetylase activity
K6V21_RS01995	COG2207	Transcriptional regulator
K6V21_RS01995	COG0662	Cupin 2, conserved barrel domain protein
K6V21_RS02000	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS02005	COG0667	Aldo Keto reductase
K6V21_RS02030	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS02035	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS02040	COG0737	Belongs to the 5'-nucleotidase family
K6V21_RS02060	COG2382	esterase
K6V21_RS02060	COG3693	PFAM glycoside hydrolase, family 10
K6V21_RS02065	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS02110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V21_RS02125	COG0297	glycogen (starch) synthase activity
K6V21_RS02145	COG1216	Glycosyl transferase, family 2
K6V21_RS02220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS02225	COG1136	(ABC) transporter
K6V21_RS02225	COG0577	efflux transmembrane transporter activity
K6V21_RS02235	COG1136	(ABC) transporter
K6V21_RS02240	COG1940	carbohydrate kinase activity
K6V21_RS02255	COG0681	Belongs to the peptidase S26 family
K6V21_RS02310	COG0335	large ribosomal subunit rRNA binding
K6V21_RS02320	COG2996	Protein conserved in bacteria
K6V21_RS02325	COG0039	L-malate dehydrogenase activity
K6V21_RS02355	COG3250	beta-galactosidase activity
K6V21_RS02385	COG0702	epimerase
K6V21_RS02390	COG4771	TonB-dependent receptor
K6V21_RS02395	COG3119	arylsulfatase activity
K6V21_RS02415	COG0235	Class ii aldolase
K6V21_RS02425	COG4806	L-rhamnose isomerase
K6V21_RS02430	COG1070	Carbohydrate kinase
K6V21_RS02440	COG3401	FG-GAP repeat protein
K6V21_RS02450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS02470	COG2207	Transcriptional regulator
K6V21_RS02490	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS02495	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS02510	COG0137	argininosuccinate synthase activity
K6V21_RS02520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6V21_RS02525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6V21_RS02555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6V21_RS02560	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS02560	COG1396	sequence-specific DNA binding
K6V21_RS02565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6V21_RS02585	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS02615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V21_RS02625	COG2890	protein-(glutamine-N5) methyltransferase activity
K6V21_RS02630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V21_RS02630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V21_RS02645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6V21_RS02650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6V21_RS02665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6V21_RS02675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6V21_RS02705	COG0702	epimerase
K6V21_RS02705	COG0702	epimerase
K6V21_RS02710	COG4771	TonB-dependent receptor
K6V21_RS02745	COG3250	beta-galactosidase activity
K6V21_RS02750	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS02755	COG3537	Alpha-1,2-mannosidase
K6V21_RS02770	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS02790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6V21_RS02805	COG0564	pseudouridine synthase activity
K6V21_RS02810	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6V21_RS02830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6V21_RS02835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6V21_RS02845	COG0463	Glycosyl transferase, family 2
K6V21_RS02845	COG1216	Glycosyl transferase, family 2
K6V21_RS02850	COG2003	Belongs to the UPF0758 family
K6V21_RS02860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V21_RS02875	COG1785	Belongs to the alkaline phosphatase family
K6V21_RS02880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6V21_RS02885	COG0280	phosphate acetyltransferase
K6V21_RS02905	COG1380	Effector of murein hydrolase LrgA
K6V21_RS02910	COG1346	cytolysis
K6V21_RS02955	COG0312	modulator of DNA gyrase
K6V21_RS02960	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6V21_RS02965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6V21_RS02970	COG4999	Histidine kinase
K6V21_RS02970	COG3850	Histidine kinase
K6V21_RS02970	COG3437	response regulator, receiver
K6V21_RS02970	COG2205	protein histidine kinase activity
K6V21_RS02980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6V21_RS02990	COG0733	neurotransmitter:sodium symporter activity
K6V21_RS03005	COG1136	(ABC) transporter
K6V21_RS03010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6V21_RS03015	COG0589	response to stress
K6V21_RS03015	COG0475	glutathione-regulated potassium exporter activity
K6V21_RS03020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6V21_RS03030	COG0702	epimerase
K6V21_RS03035	COG4206	TonB-dependent receptor
K6V21_RS03035	COG1629	transport
K6V21_RS03050	COG1649	PFAM Uncharacterised BCR, COG1649
K6V21_RS03065	COG1629	transport
K6V21_RS03065	COG4206	TonB-dependent receptor
K6V21_RS03075	COG4771	TonB-dependent receptor
K6V21_RS03095	COG3876	Protein conserved in bacteria
K6V21_RS03100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V21_RS03115	COG1216	Glycosyl transferase, family 2
K6V21_RS03115	COG0463	Glycosyl transferase, family 2
K6V21_RS03135	COG3876	Protein conserved in bacteria
K6V21_RS03155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6V21_RS03165	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V21_RS03170	COG0423	glycine-tRNA ligase activity
K6V21_RS03215	COG4771	TonB-dependent receptor
K6V21_RS03235	COG0385	Bile acid
K6V21_RS03245	COG4771	TonB-dependent receptor
K6V21_RS03280	COG1373	ATPase (AAA superfamily
K6V21_RS03290	COG2954	triphosphatase activity
K6V21_RS03315	COG0612	Peptidase, M16
K6V21_RS03325	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS03330	COG0702	epimerase
K6V21_RS03335	COG4206	TonB-dependent receptor
K6V21_RS03335	COG1629	transport
K6V21_RS03340	COG0745	RESPONSE REGULATOR receiver
K6V21_RS03340	COG3292	Two component regulator propeller
K6V21_RS03340	COG2205	protein histidine kinase activity
K6V21_RS03345	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS03350	COG1022	Amp-dependent synthetase and ligase
K6V21_RS03365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V21_RS03370	COG2207	Transcriptional regulator
K6V21_RS03370	COG4753	response regulator
K6V21_RS03390	COG3119	arylsulfatase activity
K6V21_RS03400	COG3292	Two component regulator propeller
K6V21_RS03400	COG0745	RESPONSE REGULATOR receiver
K6V21_RS03400	COG2205	protein histidine kinase activity
K6V21_RS03420	COG1629	transport
K6V21_RS03420	COG4206	TonB-dependent receptor
K6V21_RS03425	COG4942	peptidase
K6V21_RS03440	COG0756	dUTP diphosphatase activity
K6V21_RS03485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS03490	COG3119	arylsulfatase activity
K6V21_RS03495	COG0702	epimerase
K6V21_RS03500	COG4771	TonB-dependent receptor
K6V21_RS03520	COG3292	Two component regulator propeller
K6V21_RS03520	COG2205	protein histidine kinase activity
K6V21_RS03520	COG0745	RESPONSE REGULATOR receiver
K6V21_RS03525	COG5433	transposase activity
K6V21_RS03530	COG3119	arylsulfatase activity
K6V21_RS03535	COG3250	beta-galactosidase activity
K6V21_RS03560	COG0702	epimerase
K6V21_RS03565	COG4771	TonB-dependent receptor
K6V21_RS03575	COG4206	TonB-dependent receptor
K6V21_RS03575	COG1629	transport
K6V21_RS03580	COG3292	Two component regulator propeller
K6V21_RS03580	COG2205	protein histidine kinase activity
K6V21_RS03580	COG0745	RESPONSE REGULATOR receiver
K6V21_RS03615	COG2001	Belongs to the MraZ family
K6V21_RS03635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6V21_RS03640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V21_RS03645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6V21_RS03650	COG0772	Belongs to the SEDS family
K6V21_RS03655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6V21_RS03660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6V21_RS03670	COG0849	cell division
K6V21_RS03675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V21_RS03680	COG1610	YqeY-like protein
K6V21_RS03690	COG1381	Involved in DNA repair and RecF pathway recombination
K6V21_RS03700	COG0268	Binds directly to 16S ribosomal RNA
K6V21_RS03705	COG0187	DNA topoisomerase II activity
K6V21_RS03720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6V21_RS03750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6V21_RS03760	COG1629	transport
K6V21_RS03760	COG4206	TonB-dependent receptor
K6V21_RS03765	COG0702	epimerase
K6V21_RS03775	COG2431	L-lysine efflux transmembrane transporter activity
K6V21_RS03785	COG3408	Glycogen debranching enzyme
K6V21_RS03785	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K6V21_RS03790	COG5652	VanZ like family
K6V21_RS03795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K6V21_RS03805	COG0393	Putative heavy-metal-binding
K6V21_RS03815	COG1253	flavin adenine dinucleotide binding
K6V21_RS03820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6V21_RS03825	COG0719	Fe-S assembly protein
K6V21_RS03835	COG0396	ATPase activity
K6V21_RS03840	COG0719	Fe-S assembly protein
K6V21_RS03850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6V21_RS03855	COG0195	Participates in both transcription termination and antitermination
K6V21_RS03860	COG0779	Required for maturation of 30S ribosomal subunits
K6V21_RS03875	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS03880	COG2382	esterase
K6V21_RS03930	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS03945	COG4206	TonB-dependent receptor
K6V21_RS03945	COG1629	transport
K6V21_RS03960	COG1595	DNA-templated transcription, initiation
K6V21_RS03965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6V21_RS03970	COG1166	arginine decarboxylase activity
K6V21_RS03975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6V21_RS03995	COG3341	Caulimovirus viroplasmin
K6V21_RS03995	COG0328	RNA-DNA hybrid ribonuclease activity
K6V21_RS04000	COG1132	(ABC) transporter
K6V21_RS04050	COG1216	Glycosyl transferase, family 2
K6V21_RS04055	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS04060	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS04065	COG1216	Glycosyl transferase, family 2
K6V21_RS04070	COG3754	Rhamnan synthesis protein F
K6V21_RS04075	COG1215	transferase activity, transferring glycosyl groups
K6V21_RS04080	COG1216	Glycosyl transferase, family 2
K6V21_RS04080	COG1442	glycosyl transferase family 8
K6V21_RS04100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6V21_RS04125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6V21_RS04130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V21_RS04135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V21_RS04140	COG0571	ribonuclease III activity
K6V21_RS04145	COG0205	6-phosphofructokinase activity
K6V21_RS04160	COG0482	sulfurtransferase activity
K6V21_RS04175	COG0215	cysteine-tRNA ligase activity
K6V21_RS04180	COG3119	arylsulfatase activity
K6V21_RS04185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS04215	COG1538	Outer membrane efflux protein
K6V21_RS04220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V21_RS04250	COG3292	Two component regulator propeller
K6V21_RS04250	COG2205	protein histidine kinase activity
K6V21_RS04250	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04250	COG3292	Two component regulator propeller
K6V21_RS04250	COG2205	protein histidine kinase activity
K6V21_RS04250	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04255	COG3119	arylsulfatase activity
K6V21_RS04260	COG4771	TonB-dependent receptor
K6V21_RS04265	COG0702	epimerase
K6V21_RS04275	COG4771	TonB-dependent receptor
K6V21_RS04280	COG0702	epimerase
K6V21_RS04290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V21_RS04295	COG3119	arylsulfatase activity
K6V21_RS04320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6V21_RS04330	COG0681	Belongs to the peptidase S26 family
K6V21_RS04355	COG4771	TonB-dependent receptor
K6V21_RS04365	COG3250	beta-galactosidase activity
K6V21_RS04370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS04380	COG1312	Catalyzes the dehydration of D-mannonate
K6V21_RS04445	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS04450	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6V21_RS04470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6V21_RS04495	COG0681	Belongs to the peptidase S26 family
K6V21_RS04570	COG0612	Peptidase, M16
K6V21_RS04580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V21_RS04590	COG0513	Belongs to the DEAD box helicase family
K6V21_RS04605	COG1629	transport
K6V21_RS04610	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04610	COG2205	protein histidine kinase activity
K6V21_RS04610	COG3292	Two component regulator propeller
K6V21_RS04610	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04610	COG2205	protein histidine kinase activity
K6V21_RS04610	COG3292	Two component regulator propeller
K6V21_RS04675	COG0783	Belongs to the Dps family
K6V21_RS04680	COG0583	DNA-binding transcription factor activity
K6V21_RS04690	COG3634	alkyl hydroperoxide reductase activity
K6V21_RS04705	COG3591	Belongs to the peptidase S1B family
K6V21_RS04720	COG2255	four-way junction helicase activity
K6V21_RS04765	COG2197	response regulator
K6V21_RS04795	COG0702	epimerase
K6V21_RS04800	COG4771	TonB-dependent receptor
K6V21_RS04805	COG2814	Major facilitator Superfamily
K6V21_RS04805	COG0477	Major facilitator Superfamily
K6V21_RS04810	COG3292	Two component regulator propeller
K6V21_RS04810	COG2205	protein histidine kinase activity
K6V21_RS04810	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04815	COG5002	protein histidine kinase activity
K6V21_RS04815	COG0784	Response regulator, receiver
K6V21_RS04820	COG3083	sulfuric ester hydrolase activity
K6V21_RS04830	COG2715	membrane protein required for spore maturation
K6V21_RS04835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6V21_RS04845	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS04850	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS04855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS04860	COG4206	TonB-dependent receptor
K6V21_RS04860	COG1629	transport
K6V21_RS04890	COG1053	succinate dehydrogenase
K6V21_RS04895	COG3250	beta-galactosidase activity
K6V21_RS04905	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04905	COG2205	protein histidine kinase activity
K6V21_RS04905	COG3292	Two component regulator propeller
K6V21_RS04910	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V21_RS04915	COG3408	Glycogen debranching enzyme
K6V21_RS04915	COG3119	arylsulfatase activity
K6V21_RS04920	COG0702	epimerase
K6V21_RS04925	COG1629	transport
K6V21_RS04925	COG4206	TonB-dependent receptor
K6V21_RS04940	COG0673	inositol 2-dehydrogenase activity
K6V21_RS04950	COG0673	inositol 2-dehydrogenase activity
K6V21_RS04955	COG2205	protein histidine kinase activity
K6V21_RS04955	COG0745	RESPONSE REGULATOR receiver
K6V21_RS04955	COG3292	Two component regulator propeller
K6V21_RS04995	COG0464	growth
K6V21_RS05000	COG0515	serine threonine protein kinase
K6V21_RS05000	COG2815	serine threonine protein kinase
K6V21_RS05015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V21_RS05020	COG0322	excinuclease ABC activity
K6V21_RS05025	COG1490	D-aminoacyl-tRNA deacylase activity
K6V21_RS05030	COG1694	Mazg nucleotide pyrophosphohydrolase
K6V21_RS05035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V21_RS05040	COG0142	geranyltranstransferase activity
K6V21_RS05045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V21_RS05045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V21_RS05060	COG1629	transport
K6V21_RS05065	COG0012	GTP binding
K6V21_RS05085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V21_RS05090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V21_RS05100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V21_RS05110	COG4771	TonB-dependent receptor
K6V21_RS05115	COG0702	epimerase
K6V21_RS05150	COG1629	transport
K6V21_RS05155	COG0702	epimerase
K6V21_RS05205	COG0657	acetylesterase activity
K6V21_RS05210	COG4948	Mandelate Racemase Muconate Lactonizing
K6V21_RS05225	COG3292	Two component regulator propeller
K6V21_RS05225	COG2205	protein histidine kinase activity
K6V21_RS05225	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05230	COG3645	SOS response
K6V21_RS05235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V21_RS05240	COG2205	protein histidine kinase activity
K6V21_RS05240	COG3292	Two component regulator propeller
K6V21_RS05240	COG2205	protein histidine kinase activity
K6V21_RS05240	COG3292	Two component regulator propeller
K6V21_RS05240	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05240	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05245	COG1629	transport
K6V21_RS05250	COG0702	epimerase
K6V21_RS05260	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05275	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05275	COG2205	protein histidine kinase activity
K6V21_RS05275	COG3292	Two component regulator propeller
K6V21_RS05285	COG4771	TonB-dependent receptor
K6V21_RS05290	COG0702	epimerase
K6V21_RS05300	COG3250	beta-galactosidase activity
K6V21_RS05325	COG4771	TonB-dependent receptor
K6V21_RS05335	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05335	COG3292	Two component regulator propeller
K6V21_RS05335	COG2205	protein histidine kinase activity
K6V21_RS05335	COG2205	protein histidine kinase activity
K6V21_RS05335	COG3292	Two component regulator propeller
K6V21_RS05335	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05360	COG0681	Belongs to the peptidase S26 family
K6V21_RS05370	COG0681	Belongs to the peptidase S26 family
K6V21_RS05465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6V21_RS05510	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05525	COG0784	Response regulator, receiver
K6V21_RS05525	COG5002	protein histidine kinase activity
K6V21_RS05525	COG2198	Histidine kinase
K6V21_RS05545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V21_RS05560	COG1704	LemA family
K6V21_RS05575	COG5002	protein histidine kinase activity
K6V21_RS05590	COG0697	spore germination
K6V21_RS05595	COG0495	leucyl-tRNA aminoacylation
K6V21_RS05600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V21_RS05605	COG2194	sulfuric ester hydrolase activity
K6V21_RS05625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6V21_RS05650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V21_RS05650	COG0731	radical SAM domain protein
K6V21_RS05655	COG1373	ATPase (AAA superfamily
K6V21_RS05710	COG3279	Response regulator of the LytR AlgR family
K6V21_RS05720	COG0659	secondary active sulfate transmembrane transporter activity
K6V21_RS05725	COG0745	RESPONSE REGULATOR receiver
K6V21_RS05725	COG2205	protein histidine kinase activity
K6V21_RS05725	COG3292	Two component regulator propeller
K6V21_RS05735	COG1629	transport
K6V21_RS05740	COG0561	phosphatase activity
K6V21_RS05760	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS05780	COG2315	Protein conserved in bacteria
K6V21_RS05820	COG0681	Belongs to the peptidase S26 family
K6V21_RS05875	COG2801	Transposase and inactivated derivatives
K6V21_RS05885	COG3250	beta-galactosidase activity
K6V21_RS05890	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS05900	COG3693	PFAM glycoside hydrolase, family 10
K6V21_RS05900	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05900	COG2382	esterase
K6V21_RS05910	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS05915	COG3250	beta-galactosidase activity
K6V21_RS05920	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V21_RS05925	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05930	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05935	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS05940	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS05945	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V21_RS05950	COG0366	Alpha amylase catalytic
K6V21_RS05950	COG1470	cell adhesion involved in biofilm formation
K6V21_RS05970	COG1592	Rubrerythrin
K6V21_RS06045	COG0427	acetyl-CoA hydrolase
K6V21_RS06055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V21_RS06060	COG5433	transposase activity
K6V21_RS06115	COG2177	Part of the ABC transporter FtsEX involved in
K6V21_RS06125	COG1968	undecaprenyl-diphosphatase activity
K6V21_RS06130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V21_RS06135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V21_RS06145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V21_RS06160	COG4206	TonB-dependent receptor
K6V21_RS06160	COG1629	transport
K6V21_RS06165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS06175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6V21_RS06240	COG3209	COG3209 Rhs family protein
K6V21_RS06270	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS06285	COG2382	esterase
K6V21_RS06290	COG2382	esterase
K6V21_RS06300	COG4771	TonB-dependent receptor
K6V21_RS06315	COG2382	esterase
K6V21_RS06340	COG0594	ribonuclease P activity
K6V21_RS06345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6V21_RS06350	COG0084	hydrolase, TatD family'
K6V21_RS06355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6V21_RS06365	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V21_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS06445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6V21_RS06445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6V21_RS06465	COG1506	peptidase
K6V21_RS06465	COG0823	Involved in the tonB-independent uptake of proteins
K6V21_RS06475	COG0116	Belongs to the methyltransferase superfamily
K6V21_RS06480	COG1045	serine acetyltransferase
K6V21_RS06485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V21_RS06510	COG0557	exoribonuclease II activity
K6V21_RS06515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6V21_RS06555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V21_RS06565	COG0826	peptidase U32
K6V21_RS06575	COG0758	DNA mediated transformation
K6V21_RS06590	COG3250	beta-galactosidase activity
K6V21_RS06595	COG4771	TonB-dependent receptor
K6V21_RS06635	COG4771	TonB-dependent receptor
K6V21_RS06640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS06645	COG3250	beta-galactosidase activity
K6V21_RS06650	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS06660	COG0702	epimerase
K6V21_RS06665	COG1629	transport
K6V21_RS06665	COG4206	TonB-dependent receptor
K6V21_RS06685	COG2205	protein histidine kinase activity
K6V21_RS06685	COG3292	Two component regulator propeller
K6V21_RS06685	COG0745	RESPONSE REGULATOR receiver
K6V21_RS06715	COG4206	TonB-dependent receptor
K6V21_RS06715	COG1629	transport
K6V21_RS06730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS06750	COG2271	Major facilitator Superfamily
K6V21_RS06765	COG0584	glycerophosphoryl diester phosphodiesterase
K6V21_RS06775	COG4206	TonB-dependent receptor
K6V21_RS06775	COG1629	transport
K6V21_RS06785	COG1595	DNA-templated transcription, initiation
K6V21_RS06815	COG5002	protein histidine kinase activity
K6V21_RS06820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6V21_RS06825	COG1053	succinate dehydrogenase
K6V21_RS06840	COG0671	phosphoesterase, PA-phosphatase related
K6V21_RS06845	COG0793	Belongs to the peptidase S41A family
K6V21_RS06845	COG3409	Peptidoglycan-binding domain 1 protein
K6V21_RS06850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6V21_RS06865	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS06865	COG4977	sequence-specific DNA binding
K6V21_RS06900	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS06930	COG4771	TonB-dependent receptor
K6V21_RS06950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6V21_RS06955	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS06975	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K6V21_RS06985	COG2207	Transcriptional regulator
K6V21_RS06995	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V21_RS07000	COG4771	TonB-dependent receptor
K6V21_RS07005	COG0702	epimerase
K6V21_RS07025	COG4124	Belongs to the glycosyl hydrolase 26 family
K6V21_RS07060	COG2268	Band 7 protein
K6V21_RS07065	COG3279	Response regulator of the LytR AlgR family
K6V21_RS07100	COG1522	sequence-specific DNA binding
K6V21_RS07105	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V21_RS07110	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V21_RS07115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V21_RS07125	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS07145	COG2089	acid synthase
K6V21_RS07155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V21_RS07270	COG3292	Two component regulator propeller
K6V21_RS07270	COG2205	protein histidine kinase activity
K6V21_RS07270	COG0745	RESPONSE REGULATOR receiver
K6V21_RS07285	COG3537	Alpha-1,2-mannosidase
K6V21_RS07315	COG0702	epimerase
K6V21_RS07320	COG4771	TonB-dependent receptor
K6V21_RS07325	COG0606	chelatase, subunit chli
K6V21_RS07340	COG4974	Belongs to the 'phage' integrase family
K6V21_RS07345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6V21_RS07365	COG0784	Response regulator, receiver
K6V21_RS07365	COG2198	Histidine kinase
K6V21_RS07365	COG2205	protein histidine kinase activity
K6V21_RS07370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6V21_RS07375	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V21_RS07380	COG3279	Response regulator of the LytR AlgR family
K6V21_RS07465	COG5002	protein histidine kinase activity
K6V21_RS07470	COG0745	RESPONSE REGULATOR receiver
K6V21_RS07485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K6V21_RS07490	COG2205	protein histidine kinase activity
K6V21_RS07490	COG4999	Histidine kinase
K6V21_RS07490	COG3850	Histidine kinase
K6V21_RS07490	COG3437	response regulator, receiver
K6V21_RS07495	COG0318	PFAM AMP-dependent synthetase and ligase
K6V21_RS07510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6V21_RS07515	COG1217	gtp-binding protein TYPA
K6V21_RS07540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6V21_RS07545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6V21_RS07555	COG5002	protein histidine kinase activity
K6V21_RS07560	COG1012	belongs to the aldehyde dehydrogenase family
K6V21_RS07565	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V21_RS07570	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V21_RS07570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V21_RS07580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6V21_RS07585	COG0339	signal peptide processing
K6V21_RS07610	COG0018	arginyl-trna synthetase
K6V21_RS07630	COG2816	NAD+ diphosphatase activity
K6V21_RS07700	COG2176	DNA-directed DNA polymerase activity
K6V21_RS07725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V21_RS07730	COG0793	Belongs to the peptidase S41A family
K6V21_RS07745	COG4771	TonB-dependent receptor
K6V21_RS07750	COG0702	epimerase
K6V21_RS07770	COG3119	arylsulfatase activity
K6V21_RS07785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6V21_RS07855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6V21_RS07860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6V21_RS07880	COG0006	proline dipeptidase activity
K6V21_RS07895	COG2311	Membrane
K6V21_RS07940	COG2205	protein histidine kinase activity
K6V21_RS07950	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6V21_RS07955	COG1773	rubredoxin
K6V21_RS07960	COG0784	Response regulator, receiver
K6V21_RS07960	COG2198	Histidine kinase
K6V21_RS07960	COG2205	protein histidine kinase activity
K6V21_RS07965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V21_RS07970	COG1011	Hydrolase
K6V21_RS07975	COG0196	riboflavin kinase activity
K6V21_RS07980	COG1266	CAAX protease self-immunity
K6V21_RS08000	COG3655	Transcriptional regulator
K6V21_RS08005	COG2166	iron-sulfur cluster assembly
K6V21_RS08010	COG2234	aminopeptidase activity
K6V21_RS08020	COG0280	phosphate acetyltransferase
K6V21_RS08025	COG3426	butyrate kinase activity
K6V21_RS08040	COG4771	TonB-dependent receptor
K6V21_RS08055	COG4206	TonB-dependent receptor
K6V21_RS08055	COG1629	transport
K6V21_RS08075	COG1185	polyribonucleotide nucleotidyltransferase activity
K6V21_RS08085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6V21_RS08090	COG0537	adenosine 5'-monophosphoramidase activity
K6V21_RS08095	COG0662	Cupin 2, conserved barrel domain protein
K6V21_RS08095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K6V21_RS08115	COG2755	lipolytic protein G-D-S-L family
K6V21_RS08115	COG0657	acetylesterase activity
K6V21_RS08120	COG1629	transport
K6V21_RS08120	COG4206	TonB-dependent receptor
K6V21_RS08165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6V21_RS08165	COG5297	Belongs to the glycosyl hydrolase family 6
K6V21_RS08170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6V21_RS08175	COG2205	protein histidine kinase activity
K6V21_RS08175	COG3292	Two component regulator propeller
K6V21_RS08175	COG0745	RESPONSE REGULATOR receiver
K6V21_RS08180	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V21_RS08185	COG3250	beta-galactosidase activity
K6V21_RS08190	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS08215	COG3119	arylsulfatase activity
K6V21_RS08225	COG4771	TonB-dependent receptor
K6V21_RS08240	COG3537	Alpha-1,2-mannosidase
K6V21_RS08255	COG1595	DNA-templated transcription, initiation
K6V21_RS08265	COG3250	beta-galactosidase activity
K6V21_RS08290	COG2096	Adenosyltransferase
K6V21_RS08300	COG0514	ATP-dependent DNA helicase (RecQ)
K6V21_RS08315	COG3189	MarR family transcriptional regulator
K6V21_RS08325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6V21_RS08350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6V21_RS08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V21_RS08385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V21_RS08395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6V21_RS08405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6V21_RS08410	COG4974	Belongs to the 'phage' integrase family
K6V21_RS08455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6V21_RS08460	COG0081	regulation of translation
K6V21_RS08465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6V21_RS08470	COG0222	ribosome binding
K6V21_RS08475	COG0085	RNA polymerase activity
K6V21_RS08480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6V21_RS08490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6V21_RS08495	COG0049	tRNA binding
K6V21_RS08500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V21_RS08505	COG0051	transcription antitermination factor activity, RNA binding
K6V21_RS08510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6V21_RS08515	COG0088	Forms part of the polypeptide exit tunnel
K6V21_RS08520	COG0089	rRNA binding
K6V21_RS08525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6V21_RS08530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6V21_RS08535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6V21_RS08540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6V21_RS08545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6V21_RS08550	COG0255	Belongs to the universal ribosomal protein uL29 family
K6V21_RS08555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6V21_RS08560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6V21_RS08565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6V21_RS08570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6V21_RS08575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6V21_RS08580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6V21_RS08585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6V21_RS08590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6V21_RS08595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6V21_RS08600	COG1841	ribosomal large subunit assembly
K6V21_RS08605	COG0200	Binds to the 23S rRNA
K6V21_RS08610	COG0201	protein transport
K6V21_RS08620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6V21_RS08625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6V21_RS08630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6V21_RS08635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6V21_RS08640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6V21_RS08645	COG0202	RNA polymerase activity
K6V21_RS08650	COG0203	ribosomal protein L17
K6V21_RS08665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V21_RS08685	COG1228	amidohydrolase
K6V21_RS08695	COG2986	histidine ammonia-lyase
K6V21_RS08700	COG1309	transcriptional regulator
K6V21_RS08735	COG1696	Membrane protein involved in D-alanine export
K6V21_RS08750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS08780	COG3325	Belongs to the glycosyl hydrolase 18 family
K6V21_RS08780	COG3469	chitinase activity
K6V21_RS08795	COG1629	transport
K6V21_RS08800	COG1609	Transcriptional regulator
K6V21_RS08800	COG2207	Transcriptional regulator
K6V21_RS08810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS08845	COG1595	DNA-templated transcription, initiation
K6V21_RS08850	COG1629	transport
K6V21_RS08940	COG1131	(ABC) transporter
K6V21_RS09000	COG0358	DNA primase activity
K6V21_RS09030	COG0740	serine-type endopeptidase activity
K6V21_RS09090	COG2003	Belongs to the UPF0758 family
K6V21_RS09265	COG0564	pseudouridine synthase activity
K6V21_RS09320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6V21_RS09325	COG0612	Peptidase, M16
K6V21_RS09330	COG0534	Mate efflux family protein
K6V21_RS09360	COG1132	(ABC) transporter
K6V21_RS09395	COG0784	Response regulator, receiver
K6V21_RS09395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V21_RS09395	COG2198	Histidine kinase
K6V21_RS09395	COG2205	protein histidine kinase activity
K6V21_RS09400	COG0488	(ABC) transporter
K6V21_RS09405	COG3590	peptidase
K6V21_RS09410	COG0138	bifunctional purine biosynthesis protein purh
K6V21_RS09435	COG0772	Belongs to the SEDS family
K6V21_RS09445	COG1774	PSP1 C-terminal conserved region
K6V21_RS09450	COG0470	DNA polymerase III
K6V21_RS09455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6V21_RS09465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6V21_RS09470	COG0826	peptidase U32
K6V21_RS09500	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6V21_RS09505	COG0022	dehydrogenase e1 component
K6V21_RS09510	COG0716	FMN binding
K6V21_RS09515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6V21_RS09525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6V21_RS09530	COG0252	asparaginase activity
K6V21_RS09535	COG0527	aspartate kinase activity
K6V21_RS09535	COG0460	homoserine dehydrogenase
K6V21_RS09540	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K6V21_RS09610	COG2755	lipolytic protein G-D-S-L family
K6V21_RS09645	COG3250	beta-galactosidase activity
K6V21_RS09670	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V21_RS09680	COG4771	TonB-dependent receptor
K6V21_RS09685	COG0702	epimerase
K6V21_RS09700	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS09705	COG3250	beta-galactosidase activity
K6V21_RS09715	COG3250	beta-galactosidase activity
K6V21_RS09735	COG3537	Alpha-1,2-mannosidase
K6V21_RS09740	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS09745	COG0110	maltose O-acetyltransferase activity
K6V21_RS09765	COG0784	Response regulator, receiver
K6V21_RS09765	COG5002	protein histidine kinase activity
K6V21_RS09810	COG1162	GTPase activity
K6V21_RS09940	COG0456	acetyltransferase
K6V21_RS09960	COG0628	permease
K6V21_RS09965	COG1435	thymidine kinase activity
K6V21_RS09975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6V21_RS09990	COG2095	MarC family integral membrane protein
K6V21_RS10005	COG1629	transport
K6V21_RS10025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS10030	COG4771	TonB-dependent receptor
K6V21_RS10050	COG4206	TonB-dependent receptor
K6V21_RS10050	COG1629	transport
K6V21_RS10060	COG4771	TonB-dependent receptor
K6V21_RS10065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS10085	COG1629	transport
K6V21_RS10085	COG4206	TonB-dependent receptor
K6V21_RS10120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6V21_RS10130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V21_RS10130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V21_RS10150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V21_RS10155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS10160	COG1162	GTPase activity
K6V21_RS10165	COG0233	cytoplasmic translational termination
K6V21_RS10170	COG2205	protein histidine kinase activity
K6V21_RS10175	COG0528	UMP kinase activity
K6V21_RS10180	COG0534	Mate efflux family protein
K6V21_RS10190	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS10195	COG0562	UDP-galactopyranose mutase
K6V21_RS10200	COG5433	transposase activity
K6V21_RS10205	COG5433	transposase activity
K6V21_RS10210	COG5433	transposase activity
K6V21_RS10215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6V21_RS10215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6V21_RS10230	COG0792	nuclease activity
K6V21_RS10255	COG1183	phosphatidylcholine synthase activity
K6V21_RS10260	COG0688	phosphatidylethanolamine metabolic process
K6V21_RS10270	COG3118	belongs to the thioredoxin family
K6V21_RS10290	COG1538	Outer membrane efflux protein
K6V21_RS10305	COG2204	response regulator
K6V21_RS10315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6V21_RS10325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6V21_RS10350	COG1566	PFAM secretion protein HlyD family protein
K6V21_RS10360	COG2814	Major facilitator Superfamily
K6V21_RS10385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V21_RS10405	COG0823	Involved in the tonB-independent uptake of proteins
K6V21_RS10405	COG1506	peptidase
K6V21_RS10405	COG4946	Tricorn protease homolog
K6V21_RS10415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6V21_RS10475	COG0612	Peptidase, M16
K6V21_RS10495	COG0519	Catalyzes the synthesis of GMP from XMP
K6V21_RS10505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6V21_RS10525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V21_RS10530	COG0742	ribosomal rna small subunit methyltransferase
K6V21_RS10565	COG0739	heme binding
K6V21_RS10595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V21_RS10605	COG0463	Glycosyl transferase, family 2
K6V21_RS10610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V21_RS10625	COG0726	polysaccharide deacetylase
K6V21_RS10635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V21_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V21_RS10675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V21_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS10695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V21_RS10700	COG1388	LysM domain
K6V21_RS10700	COG3942	CHAP domain
K6V21_RS10715	COG1475	DNA binding
K6V21_RS10720	COG1192	Involved in chromosome partitioning
K6V21_RS10730	COG1373	ATPase (AAA superfamily
K6V21_RS10740	COG4771	TonB-dependent receptor
K6V21_RS10750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6V21_RS10755	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V21_RS10770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6V21_RS10790	COG0138	bifunctional purine biosynthesis protein purh
K6V21_RS10795	COG1196	nuclear chromosome segregation
K6V21_RS10800	COG2239	Acts as a magnesium transporter
K6V21_RS10805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6V21_RS10950	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V21_RS10985	COG2202	Pas domain
K6V21_RS10985	COG2205	protein histidine kinase activity
K6V21_RS11000	COG0668	transmembrane transport
K6V21_RS11010	COG1404	Belongs to the peptidase S8 family
K6V21_RS11010	COG4412	M6 family metalloprotease domain protein
K6V21_RS11015	COG0784	Response regulator, receiver
K6V21_RS11015	COG2205	protein histidine kinase activity
K6V21_RS11015	COG5002	protein histidine kinase activity
K6V21_RS11025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V21_RS11030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6V21_RS11035	COG0713	ATP synthesis coupled electron transport
K6V21_RS11040	COG0839	Belongs to the complex I subunit 6 family
K6V21_RS11045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V21_RS11050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6V21_RS11055	COG0649	NAD binding
K6V21_RS11055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V21_RS11060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V21_RS11065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V21_RS11075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V21_RS11080	COG0569	domain protein
K6V21_RS11090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V21_RS11105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6V21_RS11110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V21_RS11115	COG0805	protein transport
K6V21_RS11125	COG2271	Major facilitator Superfamily
K6V21_RS11130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS11140	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS11145	COG2755	lipolytic protein G-D-S-L family
K6V21_RS11150	COG3458	cephalosporin-C deacetylase activity
K6V21_RS11155	COG1629	transport
K6V21_RS11165	COG1073	alpha beta
K6V21_RS11170	COG0745	RESPONSE REGULATOR receiver
K6V21_RS11170	COG2205	protein histidine kinase activity
K6V21_RS11170	COG3292	Two component regulator propeller
K6V21_RS11180	COG0745	RESPONSE REGULATOR receiver
K6V21_RS11180	COG2205	protein histidine kinase activity
K6V21_RS11180	COG3292	Two component regulator propeller
K6V21_RS11195	COG0702	epimerase
K6V21_RS11200	COG4771	TonB-dependent receptor
K6V21_RS11210	COG0546	phosphoglycolate phosphatase activity
K6V21_RS11245	COG3250	beta-galactosidase activity
K6V21_RS11255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6V21_RS11270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6V21_RS11275	COG1506	peptidase
K6V21_RS11275	COG0823	Involved in the tonB-independent uptake of proteins
K6V21_RS11290	COG4821	SIS domain
K6V21_RS11295	COG2814	Major facilitator Superfamily
K6V21_RS11305	COG1242	4 iron, 4 sulfur cluster binding
K6V21_RS11315	COG0363	glucosamine-6-phosphate deaminase activity
K6V21_RS11330	COG0628	permease
K6V21_RS11335	COG0009	L-threonylcarbamoyladenylate synthase
K6V21_RS11340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V21_RS11345	COG0561	phosphatase activity
K6V21_RS11360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V21_RS11385	COG1629	transport
K6V21_RS11385	COG4206	TonB-dependent receptor
K6V21_RS11400	COG0745	RESPONSE REGULATOR receiver
K6V21_RS11400	COG3292	Two component regulator propeller
K6V21_RS11400	COG2205	protein histidine kinase activity
K6V21_RS11405	COG4771	TonB-dependent receptor
K6V21_RS11410	COG0702	epimerase
K6V21_RS11425	COG3292	Two component regulator propeller
K6V21_RS11425	COG2205	protein histidine kinase activity
K6V21_RS11425	COG0745	RESPONSE REGULATOR receiver
K6V21_RS11435	COG1073	alpha beta
K6V21_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS11510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V21_RS11515	COG3594	Acyltransferase
K6V21_RS11530	COG1215	transferase activity, transferring glycosyl groups
K6V21_RS11535	COG0463	Glycosyl transferase, family 2
K6V21_RS11560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V21_RS11565	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6V21_RS11570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V21_RS11575	COG0318	PFAM AMP-dependent synthetase and ligase
K6V21_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS11590	COG0726	polysaccharide deacetylase
K6V21_RS11595	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V21_RS11610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V21_RS11655	COG1629	transport
K6V21_RS11655	COG4206	TonB-dependent receptor
K6V21_RS11665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V21_RS11680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V21_RS11680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6V21_RS11685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V21_RS11690	COG1078	dGTPase activity
K6V21_RS11695	COG0284	orotidine-5'-phosphate decarboxylase activity
K6V21_RS11705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6V21_RS11710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6V21_RS11755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6V21_RS11760	COG2226	methyltransferase
K6V21_RS11765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6V21_RS11775	COG1702	phosphate starvation-inducible protein PhoH
K6V21_RS11790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V21_RS11795	COG1496	oxidoreductase activity
K6V21_RS11800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V21_RS11815	COG0563	adenylate kinase activity
K6V21_RS11820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6V21_RS11840	COG0242	peptide deformylase activity
K6V21_RS11860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS11865	COG3250	beta-galactosidase activity
K6V21_RS11870	COG3119	arylsulfatase activity
K6V21_RS11875	COG0745	RESPONSE REGULATOR receiver
K6V21_RS11875	COG2205	protein histidine kinase activity
K6V21_RS11875	COG3292	Two component regulator propeller
K6V21_RS11885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6V21_RS11885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6V21_RS11895	COG0101	tRNA pseudouridine synthase activity
K6V21_RS11905	COG1956	GAF domain-containing protein
K6V21_RS11915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V21_RS11920	COG3279	Response regulator of the LytR AlgR family
K6V21_RS11950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K6V21_RS11955	COG1690	Belongs to the RtcB family
K6V21_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS12010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6V21_RS12040	COG0793	Belongs to the peptidase S41A family
K6V21_RS12045	COG2131	deaminase
K6V21_RS12055	COG0339	signal peptide processing
K6V21_RS12065	COG1970	mechanosensitive ion channel activity
K6V21_RS12070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6V21_RS12070	COG0519	Catalyzes the synthesis of GMP from XMP
K6V21_RS12080	COG3292	Two component regulator propeller
K6V21_RS12080	COG0745	RESPONSE REGULATOR receiver
K6V21_RS12080	COG2205	protein histidine kinase activity
K6V21_RS12085	COG3254	rhamnose metabolic process
K6V21_RS12090	COG3401	FG-GAP repeat protein
K6V21_RS12095	COG0702	epimerase
K6V21_RS12100	COG4771	TonB-dependent receptor
K6V21_RS12135	COG2755	lipolytic protein G-D-S-L family
K6V21_RS12155	COG2431	L-lysine efflux transmembrane transporter activity
K6V21_RS12170	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS12185	COG0297	glycogen (starch) synthase activity
K6V21_RS12190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6V21_RS12195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6V21_RS12205	COG0543	2 iron, 2 sulfur cluster binding
K6V21_RS12215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6V21_RS12220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6V21_RS12225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6V21_RS12230	COG0546	phosphoglycolate phosphatase activity
K6V21_RS12235	COG3537	Alpha-1,2-mannosidase
K6V21_RS12255	COG1629	transport
K6V21_RS12255	COG4206	TonB-dependent receptor
K6V21_RS12285	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS12290	COG3537	Alpha-1,2-mannosidase
K6V21_RS12325	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V21_RS12370	COG1629	transport
K6V21_RS12370	COG4206	TonB-dependent receptor
K6V21_RS12390	COG3537	Alpha-1,2-mannosidase
K6V21_RS12400	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V21_RS12405	COG3537	Alpha-1,2-mannosidase
K6V21_RS12410	COG0129	dihydroxy-acid dehydratase activity
K6V21_RS12415	COG2610	gluconate transmembrane transporter activity
K6V21_RS12435	COG0791	NLP P60 protein
K6V21_RS12450	COG0612	Peptidase, M16
K6V21_RS12455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6V21_RS12460	COG1597	lipid kinase activity
K6V21_RS12465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V21_RS12485	COG4771	TonB-dependent receptor
K6V21_RS12490	COG0561	phosphatase activity
K6V21_RS12495	COG4771	TonB-dependent receptor
K6V21_RS12500	COG0702	epimerase
K6V21_RS12530	COG3693	PFAM glycoside hydrolase, family 10
K6V21_RS12530	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS12530	COG2382	esterase
K6V21_RS12535	COG2382	esterase
K6V21_RS12540	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6V21_RS12545	COG0745	RESPONSE REGULATOR receiver
K6V21_RS12545	COG3292	Two component regulator propeller
K6V21_RS12545	COG2205	protein histidine kinase activity
K6V21_RS12565	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS12570	COG2814	Major facilitator Superfamily
K6V21_RS12585	COG4771	TonB-dependent receptor
K6V21_RS12590	COG3661	Belongs to the glycosyl hydrolase 67 family
K6V21_RS12595	COG0673	inositol 2-dehydrogenase activity
K6V21_RS12610	COG2211	Major facilitator Superfamily
K6V21_RS12635	COG0561	phosphatase activity
K6V21_RS12640	COG4771	TonB-dependent receptor
K6V21_RS12645	COG0745	RESPONSE REGULATOR receiver
K6V21_RS12645	COG2205	protein histidine kinase activity
K6V21_RS12645	COG3292	Two component regulator propeller
K6V21_RS12650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V21_RS12660	COG1136	(ABC) transporter
K6V21_RS12680	COG2211	Major facilitator Superfamily
K6V21_RS12700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V21_RS12730	COG1373	ATPase (AAA superfamily
K6V21_RS12780	COG1674	ftsk spoiiie
K6V21_RS12790	COG0492	ferredoxin-NADP+ reductase activity
K6V21_RS12795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V21_RS12815	COG4771	TonB-dependent receptor
K6V21_RS12845	COG0148	phosphopyruvate hydratase activity
K6V21_RS12850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6V21_RS12855	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS12885	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS12920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS12940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6V21_RS12955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V21_RS12960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V21_RS12965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS12975	COG2814	Major facilitator Superfamily
K6V21_RS12980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V21_RS12985	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V21_RS12990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6V21_RS13005	COG0254	rRNA binding
K6V21_RS13015	COG0191	fructose-bisphosphate aldolase activity
K6V21_RS13115	COG1846	Transcriptional regulator
K6V21_RS13175	COG1216	Glycosyl transferase, family 2
K6V21_RS13200	COG0366	Alpha amylase catalytic
K6V21_RS13210	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V21_RS13215	COG0511	ligase activity, forming carbon-carbon bonds
K6V21_RS13225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V21_RS13270	COG0539	negative regulation of cytoplasmic translation
K6V21_RS13270	COG2183	response to ionizing radiation
K6V21_RS13300	COG3956	TIGRFAM MazG family protein
K6V21_RS13310	COG0525	valine-tRNA ligase activity
K6V21_RS13325	COG0653	protein targeting
K6V21_RS13330	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K6V21_RS13390	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V21_RS13430	COG0105	UTP biosynthetic process
K6V21_RS13435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6V21_RS13455	COG1253	flavin adenine dinucleotide binding
K6V21_RS13465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6V21_RS13475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6V21_RS13515	COG2706	6-phosphogluconolactonase activity
K6V21_RS13520	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS13540	COG3250	beta-galactosidase activity
K6V21_RS13550	COG3292	Two component regulator propeller
K6V21_RS13550	COG0745	RESPONSE REGULATOR receiver
K6V21_RS13550	COG2205	protein histidine kinase activity
K6V21_RS13550	COG2205	protein histidine kinase activity
K6V21_RS13550	COG3292	Two component regulator propeller
K6V21_RS13550	COG3292	Two component regulator propeller
K6V21_RS13550	COG0745	RESPONSE REGULATOR receiver
K6V21_RS13550	COG2205	protein histidine kinase activity
K6V21_RS13550	COG0745	RESPONSE REGULATOR receiver
K6V21_RS13585	COG0534	Mate efflux family protein
K6V21_RS13590	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS13610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS13615	COG1629	transport
K6V21_RS13615	COG4206	TonB-dependent receptor
K6V21_RS13670	COG3142	Participates in the control of copper homeostasis
K6V21_RS13675	COG1418	mRNA catabolic process
K6V21_RS13720	COG2267	carboxylic ester hydrolase activity
K6V21_RS13725	COG1595	DNA-templated transcription, initiation
K6V21_RS13735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V21_RS13740	COG2832	Protein of unknown function (DUF454)
K6V21_RS13755	COG0602	queuosine metabolic process
K6V21_RS13775	COG1509	lysine 2,3-aminomutase activity
K6V21_RS13785	COG1115	amino acid carrier protein
K6V21_RS13840	COG0582	viral genome integration into host DNA
K6V21_RS13880	COG1285	pathogenesis
K6V21_RS13885	COG0741	lytic transglycosylase activity
K6V21_RS13885	COG1388	LysM domain
K6V21_RS13900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6V21_RS13910	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS13930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6V21_RS14020	COG2814	Major facilitator Superfamily
K6V21_RS14035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6V21_RS14045	COG0564	pseudouridine synthase activity
K6V21_RS14055	COG0346	lactoylglutathione lyase activity
K6V21_RS14060	COG0513	Belongs to the DEAD box helicase family
K6V21_RS14135	COG1063	alcohol dehydrogenase
K6V21_RS14230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6V21_RS14335	COG4942	peptidase
K6V21_RS14375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V21_RS14385	COG0813	purine-nucleoside phosphorylase activity
K6V21_RS14390	COG4864	UPF0365 protein
K6V21_RS14405	COG0037	tRNA processing
K6V21_RS14415	COG1477	protein flavinylation
K6V21_RS14420	COG1971	Probably functions as a manganese efflux pump
K6V21_RS14435	COG0463	Glycosyl transferase, family 2
K6V21_RS14460	COG4651	solute:proton antiporter activity
K6V21_RS14460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V21_RS14470	COG0673	inositol 2-dehydrogenase activity
K6V21_RS14475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6V21_RS14480	COG0193	aminoacyl-tRNA hydrolase activity
K6V21_RS14485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6V21_RS14495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6V21_RS14500	COG1862	Preprotein translocase
K6V21_RS14510	COG0237	dephospho-CoA kinase activity
K6V21_RS14525	COG0542	response to heat
K6V21_RS14535	COG0583	DNA-binding transcription factor activity
K6V21_RS14540	COG2855	membrane
K6V21_RS14545	COG3344	reverse transcriptase
K6V21_RS14550	COG1595	DNA-templated transcription, initiation
K6V21_RS14565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6V21_RS14570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V21_RS14585	COG2076	Multidrug Resistance protein
K6V21_RS14600	COG0534	Mate efflux family protein
K6V21_RS14610	COG0443	Heat shock 70 kDa protein
K6V21_RS14665	COG0539	negative regulation of cytoplasmic translation
K6V21_RS14665	COG2183	response to ionizing radiation
K6V21_RS14725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6V21_RS14730	COG1595	DNA-templated transcription, initiation
K6V21_RS14755	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K6V21_RS14760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V21_RS14770	COG1733	regulation of RNA biosynthetic process
K6V21_RS14795	COG0656	L-ascorbic acid biosynthetic process
K6V21_RS14805	COG0667	Aldo Keto reductase
K6V21_RS14815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6V21_RS14820	COG0534	Mate efflux family protein
K6V21_RS14835	COG3275	phosphorelay sensor kinase activity
K6V21_RS14840	COG3279	Response regulator of the LytR AlgR family
K6V21_RS14845	COG4206	TonB-dependent receptor
K6V21_RS14855	COG0348	domain, Protein
K6V21_RS14875	COG0693	protein deglycase activity
K6V21_RS14900	COG5002	protein histidine kinase activity
K6V21_RS14900	COG3850	Histidine kinase
K6V21_RS14915	COG1760	l-serine dehydratase
K6V21_RS14920	COG1193	negative regulation of DNA recombination
K6V21_RS14930	COG4974	Belongs to the 'phage' integrase family
K6V21_RS14940	COG2003	Belongs to the UPF0758 family
K6V21_RS15080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V21_RS15080	COG0551	DNA topoisomerase type I activity
K6V21_RS15135	COG0738	Major facilitator superfamily
K6V21_RS15140	COG1063	alcohol dehydrogenase
K6V21_RS15160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V21_RS15185	COG4974	Belongs to the 'phage' integrase family
K6V21_RS15200	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
K6V21_RS15205	COG1431	PFAM Stem cell self-renewal protein Piwi
K6V21_RS15235	COG4771	TonB-dependent receptor
K6V21_RS15255	COG1830	Aldolase
K6V21_RS15300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS15365	COG1051	belongs to the nudix hydrolase family
K6V21_RS15375	COG2197	response regulator
K6V21_RS15390	COG2910	NAD(P)H-binding
K6V21_RS15395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6V21_RS15400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6V21_RS15410	COG2217	Heavy metal translocating P-type atpase
K6V21_RS15425	COG3437	response regulator, receiver
K6V21_RS15425	COG3850	Histidine kinase
K6V21_RS15425	COG4999	Histidine kinase
K6V21_RS15425	COG2205	protein histidine kinase activity
K6V21_RS15470	COG0784	Response regulator, receiver
K6V21_RS15470	COG5002	protein histidine kinase activity
K6V21_RS15485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6V21_RS15490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6V21_RS15500	COG2202	Pas domain
K6V21_RS15500	COG2205	protein histidine kinase activity
K6V21_RS15535	COG1918	ferrous iron import across plasma membrane
K6V21_RS15535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V21_RS15565	COG0490	domain, Protein
K6V21_RS15565	COG0471	metal ion transport
K6V21_RS15570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS15580	COG2205	protein histidine kinase activity
K6V21_RS15595	COG0346	lactoylglutathione lyase activity
K6V21_RS15610	COG1741	Belongs to the pirin family
K6V21_RS15615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V21_RS15645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6V21_RS15650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6V21_RS15660	COG4999	Histidine kinase
K6V21_RS15660	COG3437	response regulator, receiver
K6V21_RS15660	COG2205	protein histidine kinase activity
K6V21_RS15660	COG3850	Histidine kinase
K6V21_RS15665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS15675	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS15680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6V21_RS15705	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS15715	COG4771	TonB-dependent receptor
K6V21_RS15720	COG0702	epimerase
K6V21_RS15725	COG4948	Mandelate Racemase Muconate Lactonizing
K6V21_RS15740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS15820	COG4771	TonB-dependent receptor
K6V21_RS15855	COG1629	transport
K6V21_RS15860	COG1595	DNA-templated transcription, initiation
K6V21_RS15885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6V21_RS15895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V21_RS15915	COG1151	hydroxylamine reductase activity
K6V21_RS15920	COG1132	(ABC) transporter
K6V21_RS15970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V21_RS15970	COG1333	cytochrome c biogenesis protein
K6V21_RS15980	COG0716	FMN binding
K6V21_RS15995	COG2223	nitrite transmembrane transporter activity
K6V21_RS16025	COG3250	beta-galactosidase activity
K6V21_RS16030	COG0745	RESPONSE REGULATOR receiver
K6V21_RS16030	COG2205	protein histidine kinase activity
K6V21_RS16030	COG3292	Two component regulator propeller
K6V21_RS16070	COG1629	transport
K6V21_RS16085	COG4206	TonB-dependent receptor
K6V21_RS16085	COG1629	transport
K6V21_RS16090	COG0702	epimerase
K6V21_RS16115	COG3408	Glycogen debranching enzyme
K6V21_RS16135	COG3408	Glycogen debranching enzyme
K6V21_RS16145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS16170	COG4886	Leucine-rich repeat (LRR) protein
K6V21_RS16195	COG3250	beta-galactosidase activity
K6V21_RS16200	COG3250	beta-galactosidase activity
K6V21_RS16205	COG3250	beta-galactosidase activity
K6V21_RS16225	COG0439	Biotin carboxylase
K6V21_RS16235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V21_RS16245	COG0351	phosphomethylpyrimidine kinase
K6V21_RS16250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6V21_RS16255	COG0045	succinate-CoA ligase (ADP-forming) activity
K6V21_RS16260	COG2205	protein histidine kinase activity
K6V21_RS16260	COG3292	Two component regulator propeller
K6V21_RS16260	COG0745	RESPONSE REGULATOR receiver
K6V21_RS16300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6V21_RS16340	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS16355	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS16360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS16365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V21_RS16385	COG0148	phosphopyruvate hydratase activity
K6V21_RS16405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V21_RS16415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V21_RS16425	COG1979	alcohol dehydrogenase
K6V21_RS16450	COG2070	2-Nitropropane dioxygenase
K6V21_RS16455	COG0724	RNA recognition motif
K6V21_RS16460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6V21_RS16470	COG0738	Major facilitator superfamily
K6V21_RS16485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V21_RS16660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V21_RS16720	COG1196	nuclear chromosome segregation
K6V21_RS16720	COG0741	lytic transglycosylase activity
K6V21_RS16720	COG0739	heme binding
K6V21_RS16725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V21_RS16805	COG3209	COG3209 Rhs family protein
K6V21_RS16815	COG3209	COG3209 Rhs family protein
K6V21_RS16825	COG3209	COG3209 Rhs family protein
K6V21_RS16885	COG0542	response to heat
K6V21_RS16930	COG1192	Involved in chromosome partitioning
K6V21_RS16950	COG1475	DNA binding
K6V21_RS17105	COG4974	Belongs to the 'phage' integrase family
K6V21_RS17130	COG2814	Major facilitator Superfamily
K6V21_RS17145	COG1979	alcohol dehydrogenase
K6V21_RS17160	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K6V21_RS17170	COG0714	Associated with various cellular activities
K6V21_RS17230	COG2207	Transcriptional regulator
K6V21_RS17310	COG0714	Associated with various cellular activities
K6V21_RS17320	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K6V21_RS17325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6V21_RS17355	COG0788	formyltetrahydrofolate deformylase activity
K6V21_RS17360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6V21_RS17365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6V21_RS17370	COG0107	imidazoleglycerol-phosphate synthase activity
K6V21_RS17375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6V21_RS17375	COG0140	phosphoribosyl-ATP diphosphatase activity
K6V21_RS17380	COG2884	Cell division ATP-binding protein ftsE
K6V21_RS17385	COG0527	aspartate kinase activity
K6V21_RS17390	COG0019	diaminopimelate decarboxylase activity
K6V21_RS17470	COG0305	Participates in initiation and elongation during chromosome replication
K6V21_RS17495	COG5002	protein histidine kinase activity
K6V21_RS17500	COG0156	8-amino-7-oxononanoate synthase activity
K6V21_RS17520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V21_RS17520	COG0321	lipoyl(octanoyl) transferase activity
K6V21_RS17535	COG0592	DNA-directed DNA polymerase activity
K6V21_RS17555	COG0497	DNA recombination
K6V21_RS17560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V21_RS17570	COG0251	oxidation-reduction process
K6V21_RS17580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6V21_RS17590	COG0167	dihydroorotate dehydrogenase activity
K6V21_RS17595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6V21_RS17615	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6V21_RS17630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V21_RS17640	COG0573	inorganic phosphate transmembrane transporter activity
K6V21_RS17645	COG0581	inorganic phosphate transmembrane transporter activity
K6V21_RS17650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6V21_RS17655	COG0704	Plays a role in the regulation of phosphate uptake
K6V21_RS17665	COG0778	Nitroreductase
K6V21_RS17670	COG1295	ribonuclease BN
K6V21_RS17685	COG4948	Mandelate Racemase Muconate Lactonizing
K6V21_RS17695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V21_RS17705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6V21_RS17720	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6V21_RS17735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6V21_RS17760	COG1595	DNA-templated transcription, initiation
K6V21_RS17785	COG0531	amino acid
K6V21_RS17795	COG2066	Belongs to the glutaminase family
K6V21_RS17800	COG0076	glutamate decarboxylase activity
K6V21_RS17820	COG3275	phosphorelay sensor kinase activity
K6V21_RS17825	COG3279	Response regulator of the LytR AlgR family
K6V21_RS17830	COG0686	Belongs to the AlaDH PNT family
K6V21_RS17840	COG0739	heme binding
K6V21_RS17850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V21_RS17865	COG3279	Response regulator of the LytR AlgR family
K6V21_RS17890	COG0488	(ABC) transporter
K6V21_RS17900	COG0295	cytidine deaminase activity
K6V21_RS17905	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V21_RS17920	COG4771	TonB-dependent receptor
K6V21_RS17945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS17950	COG0577	efflux transmembrane transporter activity
K6V21_RS17950	COG1136	(ABC) transporter
K6V21_RS17960	COG1136	(ABC) transporter
K6V21_RS17965	COG0577	efflux transmembrane transporter activity
K6V21_RS17980	COG0577	efflux transmembrane transporter activity
K6V21_RS18020	COG0436	Aminotransferase
K6V21_RS18030	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V21_RS18035	COG1215	transferase activity, transferring glycosyl groups
K6V21_RS18045	COG2226	methyltransferase
K6V21_RS18060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6V21_RS18060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V21_RS18115	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K6V21_RS18135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V21_RS18145	COG0058	SHG alpha-glucan phosphorylase activity
K6V21_RS18150	COG0588	phosphoglycerate mutase activity
K6V21_RS18160	COG3610	response to peptide
K6V21_RS18165	COG2966	Psort location CytoplasmicMembrane, score
K6V21_RS18170	COG0602	queuosine metabolic process
K6V21_RS18175	COG1328	CTP reductase activity
K6V21_RS18180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS18185	COG0228	four-way junction DNA binding
K6V21_RS18220	COG2721	sulfolactate sulfo-lyase activity
K6V21_RS18225	COG1609	Transcriptional regulator
K6V21_RS18250	COG1858	cytochrome C peroxidase
K6V21_RS18260	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V21_RS18300	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS18305	COG0463	Glycosyl transferase, family 2
K6V21_RS18315	COG1216	Glycosyl transferase, family 2
K6V21_RS18335	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS18360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS18385	COG0252	asparaginase activity
K6V21_RS18390	COG0159	tryptophan synthase activity
K6V21_RS18395	COG0135	phosphoribosylanthranilate isomerase activity
K6V21_RS18400	COG0134	indole-3-glycerol-phosphate synthase activity
K6V21_RS18405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V21_RS18410	COG0512	Glutamine amidotransferase of anthranilate synthase
K6V21_RS18410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V21_RS18415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V21_RS18420	COG0133	tryptophan synthase activity
K6V21_RS18450	COG0004	ammonium transporteR
K6V21_RS18455	COG0347	Belongs to the P(II) protein family
K6V21_RS18465	COG0436	Aminotransferase
K6V21_RS18485	COG1177	transmembrane transport
K6V21_RS18490	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6V21_RS18495	COG3842	ATPase activity
K6V21_RS18505	COG0367	asparagine synthase
K6V21_RS18515	COG0067	glutamate synthase
K6V21_RS18515	COG0069	glutamate synthase activity
K6V21_RS18515	COG0070	glutamate synthase
K6V21_RS18520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6V21_RS18525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V21_RS18530	COG0505	Belongs to the CarA family
K6V21_RS18535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V21_RS18550	COG0235	Class ii aldolase
K6V21_RS18555	COG1070	Carbohydrate kinase
K6V21_RS18565	COG0738	Major facilitator superfamily
K6V21_RS18575	COG2207	Transcriptional regulator
K6V21_RS18575	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS18590	COG1131	(ABC) transporter
K6V21_RS18595	COG0842	Transport permease protein
K6V21_RS18600	COG0842	Transport permease protein
K6V21_RS18605	COG2755	lipolytic protein G-D-S-L family
K6V21_RS18605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6V21_RS18615	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS18620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6V21_RS18630	COG0798	PFAM Bile acid sodium symporter
K6V21_RS18670	COG4771	TonB-dependent receptor
K6V21_RS18675	COG0702	epimerase
K6V21_RS18695	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS18710	COG1022	Amp-dependent synthetase and ligase
K6V21_RS18715	COG3263	regulation of cellular component size
K6V21_RS18720	COG4191	Histidine kinase
K6V21_RS18725	COG2204	response regulator
K6V21_RS18740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V21_RS18755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6V21_RS18760	COG1058	Belongs to the CinA family
K6V21_RS18760	COG1546	Belongs to the CinA family
K6V21_RS18765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6V21_RS18770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6V21_RS18780	COG0552	protein localization to endoplasmic reticulum
K6V21_RS18785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V21_RS18800	COG0714	Associated with various cellular activities
K6V21_RS18815	COG2304	oxidoreductase activity
K6V21_RS18855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6V21_RS18860	COG0542	response to heat
K6V21_RS18865	COG0326	Molecular chaperone. Has ATPase activity
K6V21_RS18890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V21_RS18900	COG0336	Belongs to the RNA methyltransferase TrmD family
K6V21_RS18905	COG0167	dihydroorotate dehydrogenase activity
K6V21_RS18910	COG0543	2 iron, 2 sulfur cluster binding
K6V21_RS18925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V21_RS18965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6V21_RS18980	COG1136	(ABC) transporter
K6V21_RS19010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6V21_RS19015	COG1597	lipid kinase activity
K6V21_RS19020	COG0156	8-amino-7-oxononanoate synthase activity
K6V21_RS19045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V21_RS19065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V21_RS19070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V21_RS19080	COG1136	(ABC) transporter
K6V21_RS19140	COG5002	protein histidine kinase activity
K6V21_RS19170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6V21_RS19175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6V21_RS19180	COG0343	queuine tRNA-ribosyltransferase activity
K6V21_RS19190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS19195	COG3830	Belongs to the UPF0237 family
K6V21_RS19195	COG0560	Phosphoserine phosphatase
K6V21_RS19200	COG4771	TonB-dependent receptor
K6V21_RS19205	COG0702	epimerase
K6V21_RS19210	COG0513	Belongs to the DEAD box helicase family
K6V21_RS19235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS19245	COG0535	radical SAM domain protein
K6V21_RS19250	COG0297	glycogen (starch) synthase activity
K6V21_RS19260	COG1368	sulfuric ester hydrolase activity
K6V21_RS19335	COG4206	TonB-dependent receptor
K6V21_RS19335	COG1629	transport
K6V21_RS19365	COG0246	Mannitol dehydrogenase
K6V21_RS19375	COG1904	glucuronate isomerase
K6V21_RS19390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V21_RS19435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V21_RS19450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V21_RS19460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6V21_RS19465	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6V21_RS19490	COG3153	acetyltransferase
K6V21_RS19490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V21_RS19500	COG0477	Major facilitator Superfamily
K6V21_RS19500	COG2814	Major facilitator Superfamily
K6V21_RS19505	COG2115	Belongs to the xylose isomerase family
K6V21_RS19520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6V21_RS19535	COG2818	Glycosylase
K6V21_RS19635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K6V21_RS19640	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6V21_RS19670	COG2731	YhcH YjgK YiaL family protein
K6V21_RS19675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V21_RS19700	COG2205	protein histidine kinase activity
K6V21_RS19705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6V21_RS19720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6V21_RS19735	COG0540	Belongs to the ATCase OTCase family
K6V21_RS19740	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6V21_RS19755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6V21_RS19770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6V21_RS19780	COG0577	efflux transmembrane transporter activity
K6V21_RS19780	COG1136	(ABC) transporter
K6V21_RS19795	COG2204	response regulator
K6V21_RS19800	COG3852	Histidine kinase
K6V21_RS19805	COG1454	alcohol dehydrogenase
K6V21_RS19835	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V21_RS19840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V21_RS19845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6V21_RS19850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6V21_RS19855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V21_RS19860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6V21_RS19865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V21_RS19870	COG0356	it plays a direct role in the translocation of protons across the membrane
K6V21_RS19890	COG2837	iron assimilation
K6V21_RS19900	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6V21_RS19915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6V21_RS19920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6V21_RS19930	COG0724	RNA recognition motif
K6V21_RS19945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V21_RS19955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS19960	COG0297	glycogen (starch) synthase activity
K6V21_RS19965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6V21_RS19975	COG1086	Polysaccharide biosynthesis protein
K6V21_RS19980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS20095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V21_RS20100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6V21_RS20110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6V21_RS20115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V21_RS20120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V21_RS20125	COG0534	Mate efflux family protein
K6V21_RS20130	COG1136	(ABC) transporter
K6V21_RS20130	COG0577	efflux transmembrane transporter activity
K6V21_RS20145	COG1136	(ABC) transporter
K6V21_RS20145	COG0577	efflux transmembrane transporter activity
K6V21_RS20165	COG0442	prolyl-tRNA aminoacylation
K6V21_RS20180	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K6V21_RS20185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6V21_RS20200	COG2205	protein histidine kinase activity
K6V21_RS20210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K6V21_RS20215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V21_RS20220	COG1492	cobalamin metabolic process
K6V21_RS20245	COG1797	cobyrinic acid a,c-diamide synthase activity
K6V21_RS20250	COG1660	Displays ATPase and GTPase activities
K6V21_RS20255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V21_RS20265	COG4771	TonB-dependent receptor
K6V21_RS20295	COG4771	TonB-dependent receptor
K6V21_RS20330	COG4771	TonB-dependent receptor
K6V21_RS20355	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K6V21_RS20360	COG0300	oxidoreductase activity
K6V21_RS20375	COG1120	ATPase activity
K6V21_RS20390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V21_RS20395	COG3059	membrane
K6V21_RS20400	COG2207	Transcriptional regulator
K6V21_RS20400	COG0662	Cupin 2, conserved barrel domain protein
K6V21_RS20425	COG2755	lipolytic protein G-D-S-L family
K6V21_RS20425	COG0657	acetylesterase activity
K6V21_RS20430	COG3250	beta-galactosidase activity
K6V21_RS20510	COG1695	Transcriptional regulator
K6V21_RS20525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6V21_RS20540	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V21_RS20540	COG1388	LysM domain
K6V21_RS20570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V21_RS20575	COG0556	nucleotide-excision repair
K6V21_RS20585	COG1074	ATP-dependent DNA helicase activity
K6V21_RS20615	COG1475	DNA binding
K6V21_RS20620	COG3969	phosphoadenosine phosphosulfate
K6V21_RS20665	COG2819	hydrolase of the alpha beta superfamily
K6V21_RS20705	COG1678	Uncharacterized ACR, COG1678
K6V21_RS20725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6V21_RS20730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6V21_RS20790	COG3344	reverse transcriptase
K6V21_RS20810	COG0305	Participates in initiation and elongation during chromosome replication
K6V21_RS20880	COG0352	thiamine-phosphate diphosphorylase activity
K6V21_RS20890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6V21_RS20890	COG0574	Belongs to the PEP-utilizing enzyme family
K6V21_RS20895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V21_RS20900	COG0564	pseudouridine synthase activity
K6V21_RS20915	COG2814	Major facilitator Superfamily
K6V21_RS20920	COG0386	Belongs to the glutathione peroxidase family
K6V21_RS20955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V21_RS20960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS20975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V21_RS21045	COG0784	Response regulator, receiver
K6V21_RS21045	COG2205	protein histidine kinase activity
K6V21_RS21050	COG0420	3'-5' exonuclease activity
K6V21_RS21060	COG0024	Methionine aminopeptidase
K6V21_RS21070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V21_RS21085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6V21_RS21095	COG0481	GTPase activity
K6V21_RS21105	COG0259	pyridoxamine-phosphate oxidase activity
K6V21_RS21120	COG0708	Exodeoxyribonuclease III
K6V21_RS21135	COG0217	transcriptional regulatory protein
K6V21_RS21140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V21_RS21140	COG0072	phenylalanine-tRNA ligase activity
K6V21_RS21145	COG0305	Participates in initiation and elongation during chromosome replication
K6V21_RS21160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V21_RS21165	COG1216	Glycosyl transferase, family 2
K6V21_RS21170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V21_RS21175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V21_RS21190	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS21195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS21205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS21215	COG0318	PFAM AMP-dependent synthetase and ligase
K6V21_RS21220	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS21225	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS21240	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS21245	COG3754	Rhamnan synthesis protein F
K6V21_RS21320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6V21_RS21325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6V21_RS21330	COG4657	Part of a membrane complex involved in electron transport
K6V21_RS21335	COG4660	Part of a membrane complex involved in electron transport
K6V21_RS21340	COG4659	FMN binding
K6V21_RS21345	COG4658	electron transport chain
K6V21_RS21350	COG4656	Part of a membrane complex involved in electron transport
K6V21_RS21370	COG0504	CTP synthase activity
K6V21_RS21380	COG0534	Mate efflux family protein
K6V21_RS21385	COG1506	peptidase
K6V21_RS21385	COG0823	Involved in the tonB-independent uptake of proteins
K6V21_RS21390	COG3344	reverse transcriptase
K6V21_RS21405	COG2217	Heavy metal translocating P-type atpase
K6V21_RS21430	COG0357	Ribosomal RNA small subunit methyltransferase G
K6V21_RS21435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V21_RS21440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V21_RS21440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V21_RS21485	COG1272	protein, Hemolysin III
K6V21_RS21490	COG1131	(ABC) transporter
K6V21_RS21500	COG1725	Transcriptional regulator
K6V21_RS21520	COG0778	Nitroreductase
K6V21_RS21535	COG1739	Uncharacterized protein family UPF0029
K6V21_RS21545	COG1929	Belongs to the glycerate kinase type-1 family
K6V21_RS21550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6V21_RS21555	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V21_RS21605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V21_RS21610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6V21_RS21615	COG0513	Belongs to the DEAD box helicase family
K6V21_RS21620	COG2871	sodium ion transport
K6V21_RS21625	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V21_RS21635	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V21_RS21640	COG1805	sodium ion transport
K6V21_RS21645	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V21_RS21690	COG2198	Histidine kinase
K6V21_RS21690	COG2205	protein histidine kinase activity
K6V21_RS21690	COG0784	Response regulator, receiver
K6V21_RS21705	COG0612	Peptidase, M16
K6V21_RS21730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6V21_RS21735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V21_RS21785	COG0488	(ABC) transporter
K6V21_RS21795	COG1924	4 iron, 4 sulfur cluster binding
K6V21_RS21825	COG0534	Mate efflux family protein
K6V21_RS21835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V21_RS21870	COG1136	(ABC) transporter
K6V21_RS21875	COG0577	efflux transmembrane transporter activity
K6V21_RS21875	COG1136	(ABC) transporter
K6V21_RS21885	COG3279	Response regulator of the LytR AlgR family
K6V21_RS21900	COG0363	glucosamine-6-phosphate deaminase activity
K6V21_RS21905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6V21_RS21910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6V21_RS21920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V21_RS21925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V21_RS21930	COG0318	PFAM AMP-dependent synthetase and ligase
K6V21_RS21935	COG3119	arylsulfatase activity
K6V21_RS21945	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6V21_RS21970	COG0534	Mate efflux family protein
K6V21_RS21995	COG4977	sequence-specific DNA binding
K6V21_RS21995	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS22000	COG4771	TonB-dependent receptor
K6V21_RS22015	COG2205	protein histidine kinase activity
K6V21_RS22020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V21_RS22040	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS22050	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS22085	COG2244	polysaccharide biosynthetic process
K6V21_RS22100	COG5433	transposase activity
K6V21_RS22105	COG5433	transposase activity
K6V21_RS22110	COG2183	response to ionizing radiation
K6V21_RS22125	COG0488	(ABC) transporter
K6V21_RS22130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6V21_RS22135	COG0484	heat shock protein binding
K6V21_RS22145	COG4206	TonB-dependent receptor
K6V21_RS22145	COG1629	transport
K6V21_RS22165	COG3345	alpha-galactosidase
K6V21_RS22185	COG0702	epimerase
K6V21_RS22190	COG4771	TonB-dependent receptor
K6V21_RS22225	COG2814	Major facilitator Superfamily
K6V21_RS22240	COG1940	carbohydrate kinase activity
K6V21_RS22545	COG3547	Transposase (IS116 IS110 IS902 family)
K6V21_RS22575	COG0305	Participates in initiation and elongation during chromosome replication
K6V21_RS22585	COG1061	Type III restriction enzyme res subunit
K6V21_RS22600	COG0085	RNA polymerase activity
K6V21_RS22685	COG0393	Putative heavy-metal-binding
K6V21_RS22695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6V21_RS22705	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V21_RS22705	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V21_RS22705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6V21_RS22705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V21_RS22710	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V21_RS22715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6V21_RS22720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6V21_RS22725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6V21_RS22730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V21_RS22740	COG0242	peptide deformylase activity
K6V21_RS22745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6V21_RS22790	COG4974	Belongs to the 'phage' integrase family
K6V21_RS22825	COG2895	sulfate adenylyltransferase (ATP) activity
K6V21_RS22830	COG0175	sulfate reduction
K6V21_RS22835	COG0529	Catalyzes the synthesis of activated sulfate
K6V21_RS22840	COG3273	potassium ion transport
K6V21_RS22840	COG0471	metal ion transport
K6V21_RS22845	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6V21_RS22850	COG0673	inositol 2-dehydrogenase activity
K6V21_RS22855	COG3250	beta-galactosidase activity
K6V21_RS22860	COG3250	beta-galactosidase activity
K6V21_RS22865	COG3119	arylsulfatase activity
K6V21_RS22870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS22875	COG0702	epimerase
K6V21_RS22880	COG4771	TonB-dependent receptor
K6V21_RS22890	COG4771	TonB-dependent receptor
K6V21_RS22895	COG0745	RESPONSE REGULATOR receiver
K6V21_RS22895	COG2205	protein histidine kinase activity
K6V21_RS22895	COG3292	Two component regulator propeller
K6V21_RS22905	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS22910	COG3250	beta-galactosidase activity
K6V21_RS22915	COG5492	domain, Protein
K6V21_RS22945	COG1482	cell wall glycoprotein biosynthetic process
K6V21_RS22960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6V21_RS22970	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS22975	COG0745	RESPONSE REGULATOR receiver
K6V21_RS22975	COG2205	protein histidine kinase activity
K6V21_RS22975	COG3292	Two component regulator propeller
K6V21_RS22980	COG4771	TonB-dependent receptor
K6V21_RS22995	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V21_RS23020	COG2160	L-arabinose isomerase activity
K6V21_RS23040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6V21_RS23045	COG0698	ribose 5-phosphate isomerase
K6V21_RS23085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V21_RS23090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6V21_RS23090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V21_RS23105	COG1773	rubredoxin
K6V21_RS23105	COG1592	Rubrerythrin
K6V21_RS23110	COG0745	RESPONSE REGULATOR receiver
K6V21_RS23110	COG2205	protein histidine kinase activity
K6V21_RS23110	COG3292	Two component regulator propeller
K6V21_RS23120	COG1629	transport
K6V21_RS23120	COG4206	TonB-dependent receptor
K6V21_RS23130	COG1629	transport
K6V21_RS23130	COG4206	TonB-dependent receptor
K6V21_RS23135	COG0702	epimerase
K6V21_RS23150	COG5520	Belongs to the glycosyl hydrolase 30 family
K6V21_RS23175	COG0590	tRNA wobble adenosine to inosine editing
K6V21_RS23190	COG2264	protein methyltransferase activity
K6V21_RS23195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V21_RS23200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V21_RS23210	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V21_RS23230	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS23235	COG3754	Rhamnan synthesis protein F
K6V21_RS23245	COG1216	Glycosyl transferase, family 2
K6V21_RS23245	COG1442	glycosyl transferase family 8
K6V21_RS23310	COG0656	L-ascorbic acid biosynthetic process
K6V21_RS23325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS23340	COG1028	Short-chain dehydrogenase reductase Sdr
K6V21_RS23345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V21_RS23355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6V21_RS23375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6V21_RS23415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V21_RS23420	COG2373	Large extracellular alpha-helical protein
K6V21_RS23425	COG4953	penicillin-binding protein 1C
K6V21_RS23430	COG0363	glucosamine-6-phosphate deaminase activity
K6V21_RS23440	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V21_RS23445	COG3250	beta-galactosidase activity
K6V21_RS23450	COG4948	Mandelate Racemase Muconate Lactonizing
K6V21_RS23460	COG0745	RESPONSE REGULATOR receiver
K6V21_RS23460	COG2205	protein histidine kinase activity
K6V21_RS23460	COG3292	Two component regulator propeller
K6V21_RS23460	COG2205	protein histidine kinase activity
K6V21_RS23460	COG0745	RESPONSE REGULATOR receiver
K6V21_RS23460	COG3292	Two component regulator propeller
K6V21_RS23465	COG1609	Transcriptional regulator
K6V21_RS23470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS23480	COG4771	TonB-dependent receptor
K6V21_RS23535	COG1032	radical SAM domain protein
K6V21_RS23545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6V21_RS23550	COG0463	Glycosyl transferase, family 2
K6V21_RS23560	COG1410	methionine synthase
K6V21_RS23560	COG0646	methionine synthase
K6V21_RS23590	COG1408	metallophosphoesterase
K6V21_RS23605	COG0681	Belongs to the peptidase S26 family
K6V21_RS23650	COG0641	radical SAM
K6V21_RS23655	COG3591	Belongs to the peptidase S1B family
K6V21_RS23660	COG3591	Belongs to the peptidase S1B family
K6V21_RS23665	COG3118	belongs to the thioredoxin family
K6V21_RS23680	COG0488	(ABC) transporter
K6V21_RS23695	COG4206	TonB-dependent receptor
K6V21_RS23695	COG1629	transport
K6V21_RS23705	COG0745	RESPONSE REGULATOR receiver
K6V21_RS23710	COG5002	protein histidine kinase activity
K6V21_RS23725	COG3033	Beta-eliminating lyase
K6V21_RS23745	COG0629	single-stranded DNA binding
K6V21_RS23755	COG0776	regulation of translation
K6V21_RS23760	COG1530	ribonuclease E activity
K6V21_RS23765	COG1979	alcohol dehydrogenase
K6V21_RS23780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6V21_RS23790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6V21_RS23820	COG2204	response regulator
K6V21_RS23830	COG0131	Imidazoleglycerol-phosphate dehydratase
K6V21_RS23835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V21_RS23845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6V21_RS23875	COG0702	epimerase
K6V21_RS23880	COG4771	TonB-dependent receptor
K6V21_RS23935	COG4771	TonB-dependent receptor
K6V21_RS23970	COG0702	epimerase
K6V21_RS23975	COG4771	TonB-dependent receptor
K6V21_RS23995	COG4232	protein-disulfide reductase activity
K6V21_RS24005	COG0572	uridine kinase
K6V21_RS24010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V21_RS24015	COG1410	methionine synthase
K6V21_RS24015	COG0646	methionine synthase
K6V21_RS24020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6V21_RS24050	COG4771	TonB-dependent receptor
K6V21_RS24060	COG1408	metallophosphoesterase
K6V21_RS24085	COG2161	toxin-antitoxin pair type II binding
K6V21_RS24090	COG4115	mRNA cleavage
K6V21_RS24105	COG4452	Inner membrane protein CreD
K6V21_RS24130	COG1757	Na H antiporter
K6V21_RS24145	COG0482	sulfurtransferase activity
K6V21_RS24165	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K6V21_RS24170	COG1253	flavin adenine dinucleotide binding
K6V21_RS24180	COG3250	beta-galactosidase activity
K6V21_RS24190	COG4771	TonB-dependent receptor
K6V21_RS24195	COG0702	epimerase
K6V21_RS24255	COG0702	epimerase
K6V21_RS24260	COG4771	TonB-dependent receptor
K6V21_RS24280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS24290	COG3250	beta-galactosidase activity
K6V21_RS24295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V21_RS24300	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24300	COG2205	protein histidine kinase activity
K6V21_RS24300	COG3292	Two component regulator propeller
K6V21_RS24315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V21_RS24315	COG1333	cytochrome c biogenesis protein
K6V21_RS24320	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V21_RS24325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6V21_RS24340	COG2376	Dihydroxyacetone kinase
K6V21_RS24345	COG2376	Dihydroxyacetone kinase
K6V21_RS24370	COG2205	protein histidine kinase activity
K6V21_RS24370	COG3292	Two component regulator propeller
K6V21_RS24370	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24390	COG1082	Xylose isomerase domain protein TIM barrel
K6V21_RS24430	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V21_RS24445	COG0668	transmembrane transport
K6V21_RS24450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS24470	COG3279	Response regulator of the LytR AlgR family
K6V21_RS24480	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24500	COG0671	phosphoesterase, PA-phosphatase related
K6V21_RS24510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6V21_RS24515	COG0306	phosphate transporter
K6V21_RS24525	COG0586	Pfam SNARE associated Golgi protein
K6V21_RS24550	COG1119	ATPase activity
K6V21_RS24565	COG1523	belongs to the glycosyl hydrolase 13 family
K6V21_RS24570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6V21_RS24595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6V21_RS24600	COG2814	Major facilitator Superfamily
K6V21_RS24605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6V21_RS24610	COG0126	phosphoglycerate kinase activity
K6V21_RS24620	COG2066	Belongs to the glutaminase family
K6V21_RS24635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V21_RS24650	COG0778	Nitroreductase
K6V21_RS24665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V21_RS24690	COG2819	hydrolase of the alpha beta superfamily
K6V21_RS24695	COG0366	Alpha amylase catalytic
K6V21_RS24715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS24720	COG4206	TonB-dependent receptor
K6V21_RS24720	COG1629	transport
K6V21_RS24735	COG3250	beta-galactosidase activity
K6V21_RS24750	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V21_RS24755	COG4206	TonB-dependent receptor
K6V21_RS24755	COG1629	transport
K6V21_RS24765	COG2205	protein histidine kinase activity
K6V21_RS24775	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24775	COG3292	Two component regulator propeller
K6V21_RS24775	COG2205	protein histidine kinase activity
K6V21_RS24795	COG1609	Transcriptional regulator
K6V21_RS24805	COG1554	hydrolase, family 65, central catalytic
K6V21_RS24810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V21_RS24825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V21_RS24845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6V21_RS24870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6V21_RS24885	COG1280	lysine exporter protein (LysE YggA)
K6V21_RS24895	COG3292	Two component regulator propeller
K6V21_RS24895	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24895	COG2205	protein histidine kinase activity
K6V21_RS24895	COG2205	protein histidine kinase activity
K6V21_RS24895	COG0745	RESPONSE REGULATOR receiver
K6V21_RS24895	COG3292	Two component regulator propeller
K6V21_RS24915	COG1649	PFAM Uncharacterised BCR, COG1649
K6V21_RS24940	COG1966	Carbon starvation protein
K6V21_RS24945	COG1649	PFAM Uncharacterised BCR, COG1649
K6V21_RS24950	COG3275	phosphorelay sensor kinase activity
K6V21_RS24955	COG3279	Response regulator of the LytR AlgR family
K6V21_RS25015	COG3292	Two component regulator propeller
K6V21_RS25015	COG2205	protein histidine kinase activity
K6V21_RS25015	COG0745	RESPONSE REGULATOR receiver
K6V21_RS25105	COG1621	beta-fructofuranosidase activity
K6V21_RS25110	COG1629	transport
K6V21_RS25115	COG0702	epimerase
K6V21_RS25125	COG1621	beta-fructofuranosidase activity
K6V21_RS25145	COG3279	Response regulator of the LytR AlgR family
K6V21_RS25165	COG2086	electron transfer activity
K6V21_RS25170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6V21_RS25185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6V21_RS25200	COG3594	Acyltransferase
K6V21_RS25210	COG0484	heat shock protein binding
K6V21_RS25230	COG0459	protein refolding
K6V21_RS25235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6V21_RS25240	COG0385	Bile acid
K6V21_RS25260	COG0534	Mate efflux family protein
K6V21_RS25290	COG4977	sequence-specific DNA binding
K6V21_RS25290	COG1917	Cupin 2, conserved barrel domain protein
K6V21_RS25315	COG2873	o-acetylhomoserine
K6V21_RS25320	COG1360	Flagellar Motor Protein
K6V21_RS25330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6V21_RS25365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6V21_RS25375	COG0194	GDP metabolic process
K6V21_RS25390	COG1704	LemA family
K6V21_RS25405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6V21_RS25410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6V21_RS25415	COG4942	peptidase
K6V21_RS25420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6V21_RS25425	COG0750	zinc metalloprotease
K6V21_RS25435	COG0673	inositol 2-dehydrogenase activity
K6V21_RS25440	COG0632	four-way junction helicase activity
K6V21_RS25455	COG0006	proline dipeptidase activity
K6V21_RS25485	COG1505	serine-type exopeptidase activity
K6V21_RS25535	COG1373	ATPase (AAA superfamily
K6V21_RS25605	COG1216	Glycosyl transferase, family 2
K6V21_RS25625	COG1215	transferase activity, transferring glycosyl groups
K6V21_RS25660	COG0438	transferase activity, transferring glycosyl groups
K6V21_RS25705	COG3292	Two component regulator propeller
K6V21_RS25705	COG2205	protein histidine kinase activity
K6V21_RS25705	COG0745	RESPONSE REGULATOR receiver
K6V21_RS25715	COG1408	metallophosphoesterase
K6V21_RS25720	COG1575	Belongs to the MenA family. Type 1 subfamily
K6V21_RS25730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V21_RS25740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V21_RS25760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6V21_RS25765	COG0735	belongs to the Fur family
K6V21_RS25785	COG0514	ATP-dependent DNA helicase (RecQ)
K6V21_RS25795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V21_RS25815	COG0066	3-isopropylmalate dehydratase activity
K6V21_RS25820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V21_RS25825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6V21_RS25865	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V21_RS25880	COG0305	Participates in initiation and elongation during chromosome replication
K6V21_RS25915	COG4804	nuclease activity
K6V21_RS25990	COG0616	signal peptide processing
K6V21_RS25995	COG1663	tetraacyldisaccharide 4'-kinase activity
K6V21_RS26000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6V21_RS26005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6V21_RS26025	COG2205	protein histidine kinase activity
K6V21_RS26025	COG2202	Pas domain
K6V21_RS26045	COG3973	AAA domain
K6V21_RS26065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V21_RS26065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V21_RS26090	COG0617	tRNA 3'-terminal CCA addition
K6V21_RS26105	COG2204	response regulator
K6V21_RS26110	COG0488	(ABC) transporter
K6V21_RS26115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V21_RS26145	COG4206	TonB-dependent receptor
K6V21_RS26160	COG4139	cobalamin transport
K6V21_RS26165	COG1120	ATPase activity
K6V21_RS26220	COG4771	TonB-dependent receptor
K6V21_RS26235	COG1595	DNA-templated transcription, initiation
K6V21_RS26245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V21_RS26250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6V21_RS26260	COG1522	sequence-specific DNA binding
K6V21_RS26290	COG0811	peptide transport
K6V21_RS26300	COG0084	hydrolase, TatD family'
K6V21_RS26325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6V21_RS26330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6V21_RS26335	COG0205	6-phosphofructokinase activity
K6V21_RS26355	COG0372	Belongs to the citrate synthase family
K6V21_RS26360	COG0538	isocitrate dehydrogenase activity
K6V21_RS26370	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V21_RS26375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6V21_RS26385	COG0440	acetolactate synthase activity
K6V21_RS26390	COG0028	Belongs to the TPP enzyme family
K6V21_RS26400	COG1047	Peptidyl-prolyl cis-trans
K6V21_RS26405	COG3681	Belongs to the UPF0597 family
K6V21_RS26460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V21_RS26460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V21_RS26465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V21_RS26470	COG0569	domain protein
K6V21_RS26470	COG2985	domain, Protein
K6V21_RS26500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6V21_RS26505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6V21_RS26510	COG0166	Belongs to the GPI family
K6V21_RS26515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V21_RS26595	COG2502	aspartate--ammonia ligase
K6V21_RS26605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V21_RS26620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6V21_RS26630	COG0463	Glycosyl transferase, family 2
K6V21_RS26640	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6V21_RS26660	COG3250	beta-galactosidase activity