locus-tag	class	description
GN305_RS00005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GN305_RS00010	COG0322	excinuclease ABC activity
GN305_RS00015	COG1490	D-aminoacyl-tRNA deacylase activity
GN305_RS00020	COG1694	Mazg nucleotide pyrophosphohydrolase
GN305_RS00030	COG0142	geranyltranstransferase activity
GN305_RS00035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GN305_RS00035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GN305_RS00045	COG0012	GTP binding
GN305_RS00055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GN305_RS00100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GN305_RS00150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GN305_RS00160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GN305_RS00165	COG0594	ribonuclease P activity
GN305_RS00180	COG1611	Belongs to the LOG family
GN305_RS00185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GN305_RS00190	COG2814	Major facilitator Superfamily
GN305_RS00235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GN305_RS00240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GN305_RS00245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GN305_RS00250	COG1968	undecaprenyl-diphosphatase activity
GN305_RS00260	COG2177	Part of the ABC transporter FtsEX involved in
GN305_RS00270	COG1983	PspC domain protein
GN305_RS00275	COG0545	Peptidyl-prolyl cis-trans isomerase
GN305_RS00280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN305_RS00290	COG0427	acetyl-CoA hydrolase
GN305_RS00295	COG1472	Belongs to the glycosyl hydrolase 3 family
GN305_RS00305	COG3119	arylsulfatase activity
GN305_RS00310	COG3119	arylsulfatase activity
GN305_RS00320	COG1629	transport
GN305_RS00320	COG4206	TonB-dependent receptor
GN305_RS00330	COG1595	DNA-templated transcription, initiation
GN305_RS00335	COG4946	Tricorn protease homolog
GN305_RS00335	COG0793	Belongs to the peptidase S41A family
GN305_RS00340	COG0702	epimerase
GN305_RS00345	COG1629	transport
GN305_RS00350	COG3250	beta-galactosidase activity
GN305_RS00355	COG2205	protein histidine kinase activity
GN305_RS00355	COG0745	RESPONSE REGULATOR receiver
GN305_RS00355	COG3292	Two component regulator propeller
GN305_RS00355	COG3292	Two component regulator propeller
GN305_RS00355	COG2205	protein histidine kinase activity
GN305_RS00355	COG0745	RESPONSE REGULATOR receiver
GN305_RS00360	COG0495	leucyl-tRNA aminoacylation
GN305_RS00365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GN305_RS00375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GN305_RS00385	COG1629	transport
GN305_RS00395	COG2205	protein histidine kinase activity
GN305_RS00395	COG3292	Two component regulator propeller
GN305_RS00395	COG0745	RESPONSE REGULATOR receiver
GN305_RS00405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GN305_RS00430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GN305_RS00430	COG0731	radical SAM domain protein
GN305_RS00440	COG5002	protein histidine kinase activity
GN305_RS00500	COG0582	viral genome integration into host DNA
GN305_RS00505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS00520	COG0659	secondary active sulfate transmembrane transporter activity
GN305_RS00530	COG1592	Rubrerythrin
GN305_RS00535	COG3292	Two component regulator propeller
GN305_RS00535	COG2205	protein histidine kinase activity
GN305_RS00535	COG0745	RESPONSE REGULATOR receiver
GN305_RS00550	COG1629	transport
GN305_RS00580	COG1629	transport
GN305_RS00580	COG4206	TonB-dependent receptor
GN305_RS00585	COG0702	epimerase
GN305_RS00595	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS00615	COG4206	TonB-dependent receptor
GN305_RS00615	COG1629	transport
GN305_RS00620	COG0702	epimerase
GN305_RS00640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GN305_RS00665	COG2027	D-alanyl-D-alanine carboxypeptidase
GN305_RS00670	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GN305_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS00680	COG4677	pectinesterase activity
GN305_RS00685	COG4771	TonB-dependent receptor
GN305_RS00690	COG0561	phosphatase activity
GN305_RS00705	COG0726	polysaccharide deacetylase
GN305_RS00755	COG1506	peptidase
GN305_RS00755	COG0823	Involved in the tonB-independent uptake of proteins
GN305_RS00760	COG0116	Belongs to the methyltransferase superfamily
GN305_RS00770	COG0583	DNA-binding transcription factor activity
GN305_RS00775	COG0783	Belongs to the Dps family
GN305_RS00785	COG4251	negative regulation of phosphorylation
GN305_RS00790	COG1045	serine acetyltransferase
GN305_RS00795	COG0557	exoribonuclease II activity
GN305_RS00800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GN305_RS00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GN305_RS00825	COG0826	peptidase U32
GN305_RS00835	COG1629	transport
GN305_RS00840	COG0018	arginyl-trna synthetase
GN305_RS00845	COG0328	RNA-DNA hybrid ribonuclease activity
GN305_RS00845	COG3341	Caulimovirus viroplasmin
GN305_RS00855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GN305_RS00865	COG0463	Glycosyl transferase, family 2
GN305_RS00875	COG1215	transferase activity, transferring glycosyl groups
GN305_RS00885	COG1132	(ABC) transporter
GN305_RS00895	COG0438	transferase activity, transferring glycosyl groups
GN305_RS00925	COG0562	UDP-galactopyranose mutase
GN305_RS00940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GN305_RS01015	COG4206	TonB-dependent receptor
GN305_RS01015	COG1629	transport
GN305_RS01025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GN305_RS01030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GN305_RS01035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN305_RS01040	COG0571	ribonuclease III activity
GN305_RS01045	COG3119	arylsulfatase activity
GN305_RS01060	COG3119	arylsulfatase activity
GN305_RS01075	COG4206	TonB-dependent receptor
GN305_RS01075	COG1629	transport
GN305_RS01080	COG0745	RESPONSE REGULATOR receiver
GN305_RS01080	COG3292	Two component regulator propeller
GN305_RS01080	COG2205	protein histidine kinase activity
GN305_RS01085	COG0205	6-phosphofructokinase activity
GN305_RS01160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GN305_RS01190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN305_RS01225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GN305_RS01230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN305_RS01245	COG0215	cysteine-tRNA ligase activity
GN305_RS01265	COG4206	TonB-dependent receptor
GN305_RS01265	COG1629	transport
GN305_RS01270	COG1082	Xylose isomerase domain protein TIM barrel
GN305_RS01275	COG0745	RESPONSE REGULATOR receiver
GN305_RS01275	COG3292	Two component regulator propeller
GN305_RS01275	COG2205	protein histidine kinase activity
GN305_RS01280	COG3507	Belongs to the glycosyl hydrolase 43 family
GN305_RS01290	COG3119	arylsulfatase activity
GN305_RS01295	COG0482	sulfurtransferase activity
GN305_RS01305	COG3250	beta-galactosidase activity
GN305_RS01310	COG0776	regulation of translation
GN305_RS01330	COG0339	signal peptide processing
GN305_RS01335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GN305_RS01345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN305_RS01360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GN305_RS01360	COG0674	pyruvate-flavodoxin oxidoreductase activity
GN305_RS01365	COG1013	pyruvate-flavodoxin oxidoreductase activity
GN305_RS01370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GN305_RS01375	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GN305_RS01390	COG0745	RESPONSE REGULATOR receiver
GN305_RS01390	COG3292	Two component regulator propeller
GN305_RS01390	COG2205	protein histidine kinase activity
GN305_RS01445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GN305_RS01450	COG1854	S-ribosylhomocysteine lyase activity
GN305_RS01455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GN305_RS01470	COG0438	transferase activity, transferring glycosyl groups
GN305_RS01485	COG3475	LICD family
GN305_RS01510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN305_RS01510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN305_RS01550	COG4974	Belongs to the 'phage' integrase family
GN305_RS01555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GN305_RS01570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GN305_RS01585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GN305_RS01605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GN305_RS01615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GN305_RS01615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GN305_RS01620	COG2890	protein-(glutamine-N5) methyltransferase activity
GN305_RS01630	COG1040	competence protein
GN305_RS01635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GN305_RS01645	COG0165	Argininosuccinate lyase
GN305_RS01650	COG0667	Aldo Keto reductase
GN305_RS01670	COG0519	Catalyzes the synthesis of GMP from XMP
GN305_RS01675	COG3292	Two component regulator propeller
GN305_RS01675	COG0745	RESPONSE REGULATOR receiver
GN305_RS01675	COG2205	protein histidine kinase activity
GN305_RS01750	COG0358	DNA primase activity
GN305_RS01815	COG3344	reverse transcriptase
GN305_RS01835	COG3344	reverse transcriptase
GN305_RS01910	COG2198	Histidine kinase
GN305_RS01910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS01910	COG0784	Response regulator, receiver
GN305_RS01910	COG2205	protein histidine kinase activity
GN305_RS01930	COG2954	triphosphatase activity
GN305_RS01950	COG0733	neurotransmitter:sodium symporter activity
GN305_RS01960	COG1785	Belongs to the alkaline phosphatase family
GN305_RS01980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GN305_RS02075	COG0551	DNA topoisomerase type I activity
GN305_RS02075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN305_RS02125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GN305_RS02145	COG1086	Polysaccharide biosynthesis protein
GN305_RS02160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GN305_RS02195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GN305_RS02215	COG0784	Response regulator, receiver
GN305_RS02215	COG2205	protein histidine kinase activity
GN305_RS02250	COG1192	Involved in chromosome partitioning
GN305_RS02265	COG3385	transposase activity
GN305_RS02465	COG3385	transposase activity
GN305_RS02555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GN305_RS02560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GN305_RS02565	COG1663	tetraacyldisaccharide 4'-kinase activity
GN305_RS02570	COG0616	signal peptide processing
GN305_RS02620	COG0811	peptide transport
GN305_RS02650	COG1131	(ABC) transporter
GN305_RS02670	COG0534	Mate efflux family protein
GN305_RS02680	COG1187	pseudouridine synthase activity
GN305_RS02685	COG0017	Asparaginyl-tRNA synthetase
GN305_RS02705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GN305_RS02710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GN305_RS02715	COG0052	Belongs to the universal ribosomal protein uS2 family
GN305_RS02720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GN305_RS02730	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GN305_RS02735	COG0179	Fumarylacetoacetate (FAA) hydrolase
GN305_RS02740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GN305_RS02745	COG1575	Belongs to the MenA family. Type 1 subfamily
GN305_RS02750	COG1408	metallophosphoesterase
GN305_RS02760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GN305_RS02770	COG0194	GDP metabolic process
GN305_RS02780	COG1214	PFAM Peptidase M22, glycoprotease
GN305_RS02790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GN305_RS02795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GN305_RS02800	COG0739	heme binding
GN305_RS02805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GN305_RS02810	COG0750	zinc metalloprotease
GN305_RS02825	COG1272	protein, Hemolysin III
GN305_RS02830	COG0617	tRNA 3'-terminal CCA addition
GN305_RS02840	COG0632	four-way junction helicase activity
GN305_RS02845	COG0673	inositol 2-dehydrogenase activity
GN305_RS02850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GN305_RS02865	COG1621	beta-fructofuranosidase activity
GN305_RS02875	COG1105	Belongs to the carbohydrate kinase PfkB family
GN305_RS02880	COG0745	RESPONSE REGULATOR receiver
GN305_RS02880	COG2205	protein histidine kinase activity
GN305_RS02880	COG3292	Two component regulator propeller
GN305_RS02890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GN305_RS02900	COG0254	rRNA binding
GN305_RS02905	COG0191	fructose-bisphosphate aldolase activity
GN305_RS02950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GN305_RS02950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GN305_RS02960	COG0563	adenylate kinase activity
GN305_RS02965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GN305_RS03005	COG0138	bifunctional purine biosynthesis protein purh
GN305_RS03050	COG1482	cell wall glycoprotein biosynthetic process
GN305_RS03055	COG2706	6-phosphogluconolactonase activity
GN305_RS03070	COG0523	cobalamin synthesis protein
GN305_RS03085	COG4771	TonB-dependent receptor
GN305_RS03090	COG2205	protein histidine kinase activity
GN305_RS03090	COG3292	Two component regulator propeller
GN305_RS03090	COG0745	RESPONSE REGULATOR receiver
GN305_RS03110	COG3437	response regulator, receiver
GN305_RS03110	COG2205	protein histidine kinase activity
GN305_RS03110	COG4999	Histidine kinase
GN305_RS03110	COG3850	Histidine kinase
GN305_RS03115	COG5002	protein histidine kinase activity
GN305_RS03120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS03125	COG1007	ATP synthesis coupled electron transport
GN305_RS03130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN305_RS03135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GN305_RS03145	COG0839	Belongs to the complex I subunit 6 family
GN305_RS03150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN305_RS03155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GN305_RS03160	COG0649	NAD binding
GN305_RS03165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN305_RS03170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN305_RS03175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GN305_RS03180	COG0569	domain protein
GN305_RS03185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GN305_RS03195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GN305_RS03210	COG3250	beta-galactosidase activity
GN305_RS03225	COG3119	arylsulfatase activity
GN305_RS03230	COG0702	epimerase
GN305_RS03235	COG1629	transport
GN305_RS03235	COG4206	TonB-dependent receptor
GN305_RS03260	COG3250	beta-galactosidase activity
GN305_RS03270	COG4771	TonB-dependent receptor
GN305_RS03335	COG0358	DNA primase activity
GN305_RS03415	COG3344	reverse transcriptase
GN305_RS03480	COG3385	transposase activity
GN305_RS03500	COG2205	protein histidine kinase activity
GN305_RS03500	COG0784	Response regulator, receiver
GN305_RS03500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS03500	COG2198	Histidine kinase
GN305_RS03520	COG0551	DNA topoisomerase type I activity
GN305_RS03520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN305_RS03555	COG4974	Belongs to the 'phage' integrase family
GN305_RS03595	COG1629	transport
GN305_RS03595	COG4206	TonB-dependent receptor
GN305_RS03620	COG2205	protein histidine kinase activity
GN305_RS03620	COG3292	Two component regulator propeller
GN305_RS03620	COG0745	RESPONSE REGULATOR receiver
GN305_RS03630	COG3250	beta-galactosidase activity
GN305_RS03635	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS03645	COG3940	Belongs to the glycosyl hydrolase 43 family
GN305_RS03645	COG3940	Belongs to the glycosyl hydrolase 43 family
GN305_RS03660	COG1629	transport
GN305_RS03670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS03685	COG0745	RESPONSE REGULATOR receiver
GN305_RS03685	COG2205	protein histidine kinase activity
GN305_RS03685	COG3292	Two component regulator propeller
GN305_RS03690	COG1012	belongs to the aldehyde dehydrogenase family
GN305_RS03715	COG2271	Major facilitator Superfamily
GN305_RS03720	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GN305_RS03725	COG3775	system Galactitol-specific IIC component
GN305_RS03730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS03735	COG4677	pectinesterase activity
GN305_RS03740	COG1629	transport
GN305_RS03750	COG0515	serine threonine protein kinase
GN305_RS03750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GN305_RS03755	COG4771	TonB-dependent receptor
GN305_RS03760	COG0702	epimerase
GN305_RS03765	COG3507	Belongs to the glycosyl hydrolase 43 family
GN305_RS03795	COG4771	TonB-dependent receptor
GN305_RS03825	COG1917	Cupin 2, conserved barrel domain protein
GN305_RS03840	COG2755	lipolytic protein G-D-S-L family
GN305_RS03845	COG0745	RESPONSE REGULATOR receiver
GN305_RS03845	COG2205	protein histidine kinase activity
GN305_RS03845	COG3292	Two component regulator propeller
GN305_RS03855	COG0823	Involved in the tonB-independent uptake of proteins
GN305_RS03855	COG1506	peptidase
GN305_RS03870	COG0138	bifunctional purine biosynthesis protein purh
GN305_RS03890	COG0768	penicillin binding
GN305_RS03895	COG0772	Belongs to the SEDS family
GN305_RS03905	COG1774	PSP1 C-terminal conserved region
GN305_RS03910	COG0470	DNA polymerase III
GN305_RS03915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GN305_RS03930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GN305_RS03945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GN305_RS03955	COG0628	permease
GN305_RS03960	COG1435	thymidine kinase activity
GN305_RS03965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GN305_RS03985	COG1629	transport
GN305_RS04000	COG4206	TonB-dependent receptor
GN305_RS04000	COG1629	transport
GN305_RS04010	COG1629	transport
GN305_RS04010	COG4206	TonB-dependent receptor
GN305_RS04020	COG4771	TonB-dependent receptor
GN305_RS04030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GN305_RS04045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GN305_RS04045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GN305_RS04055	COG0531	amino acid
GN305_RS04065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GN305_RS04070	COG1566	PFAM secretion protein HlyD family protein
GN305_RS04080	COG1162	GTPase activity
GN305_RS04085	COG0233	cytoplasmic translational termination
GN305_RS04090	COG0406	alpha-ribazole phosphatase activity
GN305_RS04105	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS04110	COG0528	UMP kinase activity
GN305_RS04115	COG0534	Mate efflux family protein
GN305_RS04125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GN305_RS04125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GN305_RS04140	COG0792	nuclease activity
GN305_RS04160	COG1183	phosphatidylcholine synthase activity
GN305_RS04165	COG0688	phosphatidylethanolamine metabolic process
GN305_RS04195	COG0802	atpase or kinase
GN305_RS04200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GN305_RS04215	COG1830	Aldolase
GN305_RS04220	COG0588	phosphoglycerate mutase activity
GN305_RS04235	COG0475	glutathione-regulated potassium exporter activity
GN305_RS04315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GN305_RS04330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GN305_RS04335	COG0742	ribosomal rna small subunit methyltransferase
GN305_RS04350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GN305_RS04355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GN305_RS04360	COG0739	heme binding
GN305_RS04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GN305_RS04375	COG1388	LysM domain
GN305_RS04375	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN305_RS04385	COG1475	DNA binding
GN305_RS04390	COG1192	Involved in chromosome partitioning
GN305_RS04395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GN305_RS04400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN305_RS04415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GN305_RS04430	COG1196	nuclear chromosome segregation
GN305_RS04435	COG2239	Acts as a magnesium transporter
GN305_RS04440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GN305_RS04450	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN305_RS04455	COG0590	tRNA wobble adenosine to inosine editing
GN305_RS04460	COG1396	sequence-specific DNA binding
GN305_RS04470	COG3550	peptidyl-serine autophosphorylation
GN305_RS04475	COG2373	Large extracellular alpha-helical protein
GN305_RS04495	COG0205	6-phosphofructokinase activity
GN305_RS04500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GN305_RS04505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GN305_RS04520	COG0084	hydrolase, TatD family'
GN305_RS04530	COG0811	peptide transport
GN305_RS04560	COG1522	sequence-specific DNA binding
GN305_RS04575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GN305_RS04585	COG1595	DNA-templated transcription, initiation
GN305_RS04595	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GN305_RS04595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GN305_RS04620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GN305_RS04625	COG0538	isocitrate dehydrogenase activity
GN305_RS04630	COG0372	Belongs to the citrate synthase family
GN305_RS04645	COG1902	pentaerythritol trinitrate reductase activity
GN305_RS04675	COG0205	6-phosphofructokinase activity
GN305_RS04680	COG0546	phosphoglycolate phosphatase activity
GN305_RS04695	COG0511	ligase activity, forming carbon-carbon bonds
GN305_RS04700	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GN305_RS04705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS04715	COG0561	phosphatase activity
GN305_RS04720	COG4771	TonB-dependent receptor
GN305_RS04750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GN305_RS04770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GN305_RS04775	COG1506	peptidase
GN305_RS04775	COG0823	Involved in the tonB-independent uptake of proteins
GN305_RS04780	COG1242	4 iron, 4 sulfur cluster binding
GN305_RS04785	COG0426	domain, Protein
GN305_RS04790	COG0668	transmembrane transport
GN305_RS04795	COG0009	L-threonylcarbamoyladenylate synthase
GN305_RS04800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GN305_RS04860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN305_RS04865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GN305_RS04870	COG0066	3-isopropylmalate dehydratase activity
GN305_RS04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN305_RS04880	COG0473	3-isopropylmalate dehydrogenase activity
GN305_RS04890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GN305_RS04900	COG0514	ATP-dependent DNA helicase (RecQ)
GN305_RS04920	COG0735	belongs to the Fur family
GN305_RS04925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GN305_RS04935	COG4771	TonB-dependent receptor
GN305_RS04950	COG2755	lipolytic protein G-D-S-L family
GN305_RS04965	COG1629	transport
GN305_RS04965	COG4206	TonB-dependent receptor
GN305_RS04970	COG0702	epimerase
GN305_RS04985	COG0488	(ABC) transporter
GN305_RS04990	COG3590	peptidase
GN305_RS05000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS05015	COG0673	inositol 2-dehydrogenase activity
GN305_RS05020	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GN305_RS05025	COG0826	peptidase U32
GN305_RS05035	COG4771	TonB-dependent receptor
GN305_RS05050	COG0095	Lipoate-protein ligase
GN305_RS05055	COG0508	dehydrogenase complex catalyzes the overall conversion of
GN305_RS05060	COG0022	dehydrogenase e1 component
GN305_RS05065	COG0716	FMN binding
GN305_RS05070	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GN305_RS05080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GN305_RS05095	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GN305_RS05100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GN305_RS05105	COG1120	ATPase activity
GN305_RS05110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GN305_RS05135	COG1073	alpha beta
GN305_RS05155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GN305_RS05160	COG0436	Aminotransferase
GN305_RS05170	COG1733	regulation of RNA biosynthetic process
GN305_RS05180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GN305_RS05185	COG0628	permease
GN305_RS05195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS05200	COG0514	ATP-dependent DNA helicase (RecQ)
GN305_RS05205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GN305_RS05205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GN305_RS05215	COG0006	proline dipeptidase activity
GN305_RS05230	COG1418	mRNA catabolic process
GN305_RS05245	COG2832	Protein of unknown function (DUF454)
GN305_RS05255	COG0602	queuosine metabolic process
GN305_RS05275	COG1115	amino acid carrier protein
GN305_RS05285	COG2205	protein histidine kinase activity
GN305_RS05285	COG0745	RESPONSE REGULATOR receiver
GN305_RS05285	COG3292	Two component regulator propeller
GN305_RS05295	COG3681	Belongs to the UPF0597 family
GN305_RS05400	COG4974	Belongs to the 'phage' integrase family
GN305_RS05410	COG2003	Belongs to the UPF0758 family
GN305_RS05505	COG3344	reverse transcriptase
GN305_RS05585	COG0210	DNA helicase
GN305_RS05605	COG0551	DNA topoisomerase type I activity
GN305_RS05605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN305_RS05645	COG0534	Mate efflux family protein
GN305_RS05675	COG0546	phosphoglycolate phosphatase activity
GN305_RS05685	COG2207	Transcriptional regulator
GN305_RS05710	COG4771	TonB-dependent receptor
GN305_RS05715	COG0702	epimerase
GN305_RS05720	COG3250	beta-galactosidase activity
GN305_RS05725	COG0745	RESPONSE REGULATOR receiver
GN305_RS05725	COG3292	Two component regulator propeller
GN305_RS05725	COG2205	protein histidine kinase activity
GN305_RS05750	COG4771	TonB-dependent receptor
GN305_RS05835	COG1629	transport
GN305_RS05835	COG4206	TonB-dependent receptor
GN305_RS05845	COG0126	phosphoglycerate kinase activity
GN305_RS05855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS05875	COG0534	Mate efflux family protein
GN305_RS05880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GN305_RS05885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GN305_RS05910	COG1629	transport
GN305_RS05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS05925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS05940	COG2205	protein histidine kinase activity
GN305_RS05940	COG0745	RESPONSE REGULATOR receiver
GN305_RS05940	COG3292	Two component regulator propeller
GN305_RS05945	COG4771	TonB-dependent receptor
GN305_RS06000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GN305_RS06015	COG0321	lipoyl(octanoyl) transferase activity
GN305_RS06015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GN305_RS06020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GN305_RS06025	COG1834	amidinotransferase
GN305_RS06035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GN305_RS06045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GN305_RS06105	COG4804	nuclease activity
GN305_RS06115	COG4413	Urea transporter
GN305_RS06120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GN305_RS06135	COG3591	Belongs to the peptidase S1B family
GN305_RS06140	COG3591	Belongs to the peptidase S1B family
GN305_RS06155	COG1408	metallophosphoesterase
GN305_RS06160	COG0646	methionine synthase
GN305_RS06160	COG1410	methionine synthase
GN305_RS06165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GN305_RS06170	COG0463	Glycosyl transferase, family 2
GN305_RS06215	COG2311	Membrane
GN305_RS06220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GN305_RS06230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GN305_RS06250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GN305_RS06260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GN305_RS06265	COG1032	radical SAM domain protein
GN305_RS06280	COG5434	Belongs to the glycosyl hydrolase 28 family
GN305_RS06310	COG2264	protein methyltransferase activity
GN305_RS06350	COG0673	inositol 2-dehydrogenase activity
GN305_RS06355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GN305_RS06405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GN305_RS06415	COG2160	L-arabinose isomerase activity
GN305_RS06440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GN305_RS06460	COG0484	heat shock protein binding
GN305_RS06465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GN305_RS06470	COG0488	(ABC) transporter
GN305_RS06490	COG0393	Putative heavy-metal-binding
GN305_RS06530	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN305_RS06530	COG1388	LysM domain
GN305_RS06540	COG1136	(ABC) transporter
GN305_RS06545	COG0577	efflux transmembrane transporter activity
GN305_RS06555	COG0577	efflux transmembrane transporter activity
GN305_RS06555	COG1136	(ABC) transporter
GN305_RS06565	COG0577	efflux transmembrane transporter activity
GN305_RS06565	COG1136	(ABC) transporter
GN305_RS06590	COG2204	response regulator
GN305_RS06595	COG4191	Histidine kinase
GN305_RS06615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GN305_RS06620	COG0572	uridine kinase
GN305_RS06625	COG4974	Belongs to the 'phage' integrase family
GN305_RS06675	COG1484	DNA-dependent DNA replication
GN305_RS06755	COG0739	heme binding
GN305_RS06820	COG0784	Response regulator, receiver
GN305_RS06820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS06820	COG2205	protein histidine kinase activity
GN305_RS06820	COG2198	Histidine kinase
GN305_RS06830	COG0010	Belongs to the arginase family
GN305_RS06835	COG0058	SHG alpha-glucan phosphorylase activity
GN305_RS06840	COG4651	solute:proton antiporter activity
GN305_RS06840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GN305_RS06845	COG0205	6-phosphofructokinase activity
GN305_RS06860	COG0588	phosphoglycerate mutase activity
GN305_RS06865	COG1830	Aldolase
GN305_RS06875	COG2095	MarC family integral membrane protein
GN305_RS06910	COG2205	protein histidine kinase activity
GN305_RS06910	COG0745	RESPONSE REGULATOR receiver
GN305_RS06910	COG3292	Two component regulator propeller
GN305_RS06915	COG1629	transport
GN305_RS06920	COG0702	epimerase
GN305_RS06990	COG2205	protein histidine kinase activity
GN305_RS06990	COG3292	Two component regulator propeller
GN305_RS06990	COG0745	RESPONSE REGULATOR receiver
GN305_RS06990	COG0745	RESPONSE REGULATOR receiver
GN305_RS06990	COG2205	protein histidine kinase activity
GN305_RS06990	COG3292	Two component regulator propeller
GN305_RS07055	COG0622	Phosphoesterase
GN305_RS07105	COG3344	reverse transcriptase
GN305_RS07210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GN305_RS07215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GN305_RS07220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GN305_RS07225	COG0131	Imidazoleglycerol-phosphate dehydratase
GN305_RS07240	COG1592	Rubrerythrin
GN305_RS07240	COG1773	rubredoxin
GN305_RS07250	COG3118	belongs to the thioredoxin family
GN305_RS07265	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN305_RS07275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GN305_RS07280	COG0157	Belongs to the NadC ModD family
GN305_RS07285	COG2205	protein histidine kinase activity
GN305_RS07285	COG0745	RESPONSE REGULATOR receiver
GN305_RS07285	COG3292	Two component regulator propeller
GN305_RS07295	COG4771	TonB-dependent receptor
GN305_RS07310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GN305_RS07315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GN305_RS07335	COG0443	Heat shock 70 kDa protein
GN305_RS07375	COG0110	maltose O-acetyltransferase activity
GN305_RS07395	COG1216	Glycosyl transferase, family 2
GN305_RS07410	COG0562	UDP-galactopyranose mutase
GN305_RS07460	COG0556	nucleotide-excision repair
GN305_RS07480	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS07490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GN305_RS07495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GN305_RS07500	COG1169	isochorismate synthase
GN305_RS07505	COG2050	protein possibly involved in aromatic compounds catabolism
GN305_RS07510	COG0490	domain, Protein
GN305_RS07510	COG0471	metal ion transport
GN305_RS07515	COG0534	Mate efflux family protein
GN305_RS07520	COG0446	pyridine nucleotide-disulphide oxidoreductase
GN305_RS07535	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GN305_RS07545	COG4771	TonB-dependent receptor
GN305_RS07555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS07570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GN305_RS07575	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GN305_RS07585	COG0569	domain protein
GN305_RS07600	COG1760	l-serine dehydratase
GN305_RS07620	COG4771	TonB-dependent receptor
GN305_RS07645	COG2226	methyltransferase
GN305_RS07655	COG0582	viral genome integration into host DNA
GN305_RS07660	COG1193	negative regulation of DNA recombination
GN305_RS07685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GN305_RS07685	COG2755	lipolytic protein G-D-S-L family
GN305_RS07695	COG2217	Heavy metal translocating P-type atpase
GN305_RS07705	COG4221	oxidoreductase activity
GN305_RS07715	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GN305_RS07720	COG0511	ligase activity, forming carbon-carbon bonds
GN305_RS07730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN305_RS07745	COG0778	Nitroreductase
GN305_RS07760	COG0561	phosphatase activity
GN305_RS07765	COG0424	maF-like protein
GN305_RS07775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GN305_RS07790	COG2814	Major facilitator Superfamily
GN305_RS07795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS07800	COG1309	transcriptional regulator
GN305_RS07810	COG0596	Alpha beta hydrolase
GN305_RS07810	COG2226	methyltransferase
GN305_RS07810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GN305_RS07815	COG1132	(ABC) transporter
GN305_RS07970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GN305_RS07975	COG0646	methionine synthase
GN305_RS07975	COG1410	methionine synthase
GN305_RS07980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN305_RS07990	COG2233	PERMEase
GN305_RS07995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GN305_RS08010	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GN305_RS08010	COG0778	Nitroreductase
GN305_RS08020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GN305_RS08025	COG1704	LemA family
GN305_RS08040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GN305_RS08045	COG2226	methyltransferase
GN305_RS08050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GN305_RS08055	COG1702	phosphate starvation-inducible protein PhoH
GN305_RS08065	COG0101	tRNA pseudouridine synthase activity
GN305_RS08080	COG1047	Peptidyl-prolyl cis-trans
GN305_RS08090	COG0129	dihydroxy-acid dehydratase activity
GN305_RS08110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GN305_RS08135	COG1253	flavin adenine dinucleotide binding
GN305_RS08155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GN305_RS08170	COG0653	protein targeting
GN305_RS08200	COG0525	valine-tRNA ligase activity
GN305_RS08205	COG3956	TIGRFAM MazG family protein
GN305_RS08215	COG4771	TonB-dependent receptor
GN305_RS08230	COG1595	DNA-templated transcription, initiation
GN305_RS08235	COG1234	tRNA 3'-trailer cleavage
GN305_RS08255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GN305_RS08275	COG3275	phosphorelay sensor kinase activity
GN305_RS08310	COG1215	transferase activity, transferring glycosyl groups
GN305_RS08315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GN305_RS08325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GN305_RS08330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN305_RS08355	COG0738	Major facilitator superfamily
GN305_RS08360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GN305_RS08370	COG2204	response regulator
GN305_RS08390	COG0708	Exodeoxyribonuclease III
GN305_RS08405	COG1741	Belongs to the pirin family
GN305_RS08420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GN305_RS08430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GN305_RS08445	COG0793	Belongs to the peptidase S41A family
GN305_RS08450	COG2131	deaminase
GN305_RS08460	COG0339	signal peptide processing
GN305_RS08475	COG1477	protein flavinylation
GN305_RS08480	COG1971	Probably functions as a manganese efflux pump
GN305_RS08495	COG0463	Glycosyl transferase, family 2
GN305_RS08510	COG0514	ATP-dependent DNA helicase (RecQ)
GN305_RS08520	COG0148	phosphopyruvate hydratase activity
GN305_RS08530	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS08540	COG3408	Glycogen debranching enzyme
GN305_RS08565	COG0662	Cupin 2, conserved barrel domain protein
GN305_RS08565	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GN305_RS08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN305_RS08575	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GN305_RS08595	COG1216	Glycosyl transferase, family 2
GN305_RS08600	COG0463	Glycosyl transferase, family 2
GN305_RS08615	COG0297	glycogen (starch) synthase activity
GN305_RS08635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN305_RS08650	COG1388	LysM domain
GN305_RS08650	COG4641	Protein conserved in bacteria
GN305_RS08705	COG3023	N-Acetylmuramoyl-L-alanine amidase
GN305_RS08780	COG3250	beta-galactosidase activity
GN305_RS08795	COG2985	domain, Protein
GN305_RS08795	COG0490	domain, Protein
GN305_RS08800	COG1629	transport
GN305_RS08800	COG4206	TonB-dependent receptor
GN305_RS08810	COG4771	TonB-dependent receptor
GN305_RS08820	COG3250	beta-galactosidase activity
GN305_RS08825	COG3250	beta-galactosidase activity
GN305_RS08830	COG3940	Belongs to the glycosyl hydrolase 43 family
GN305_RS08855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN305_RS08860	COG0110	maltose O-acetyltransferase activity
GN305_RS08885	COG1216	Glycosyl transferase, family 2
GN305_RS08890	COG0438	transferase activity, transferring glycosyl groups
GN305_RS08895	COG1216	Glycosyl transferase, family 2
GN305_RS08900	COG0463	Glycosyl transferase, family 2
GN305_RS08905	COG0438	transferase activity, transferring glycosyl groups
GN305_RS08930	COG0463	Glycosyl transferase, family 2
GN305_RS08930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GN305_RS08935	COG1216	Glycosyl transferase, family 2
GN305_RS08945	COG1216	Glycosyl transferase, family 2
GN305_RS09000	COG3206	protein involved in exopolysaccharide biosynthesis
GN305_RS09000	COG0489	protein tyrosine kinase activity
GN305_RS09010	COG1132	(ABC) transporter
GN305_RS09060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GN305_RS09090	COG0598	Magnesium transport protein CorA
GN305_RS09095	COG1522	sequence-specific DNA binding
GN305_RS09105	COG0586	Pfam SNARE associated Golgi protein
GN305_RS09115	COG0306	phosphate transporter
GN305_RS09125	COG4771	TonB-dependent receptor
GN305_RS09135	COG2873	o-acetylhomoserine
GN305_RS09140	COG1620	l-lactate permease
GN305_RS09160	COG2205	protein histidine kinase activity
GN305_RS09185	COG0668	transmembrane transport
GN305_RS09190	COG0318	PFAM AMP-dependent synthetase and ligase
GN305_RS09200	COG0307	riboflavin synthase, alpha
GN305_RS09205	COG1295	ribonuclease BN
GN305_RS09230	COG0737	Belongs to the 5'-nucleotidase family
GN305_RS09240	COG4771	TonB-dependent receptor
GN305_RS09245	COG1509	lysine 2,3-aminomutase activity
GN305_RS09255	COG3408	Glycogen debranching enzyme
GN305_RS09270	COG0784	Response regulator, receiver
GN305_RS09270	COG2205	protein histidine kinase activity
GN305_RS09280	COG3059	membrane
GN305_RS09285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GN305_RS09290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GN305_RS09310	COG1914	H( )-stimulated, divalent metal cation uptake system
GN305_RS09315	COG3263	regulation of cellular component size
GN305_RS09320	COG0534	Mate efflux family protein
GN305_RS09330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GN305_RS09340	COG0488	(ABC) transporter
GN305_RS09415	COG0228	four-way junction DNA binding
GN305_RS09425	COG0657	acetylesterase activity
GN305_RS09425	COG2755	lipolytic protein G-D-S-L family
GN305_RS09450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GN305_RS09455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GN305_RS09490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GN305_RS09495	COG1333	cytochrome c biogenesis protein
GN305_RS09495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GN305_RS09515	COG1730	sister chromatid segregation
GN305_RS09530	COG0438	transferase activity, transferring glycosyl groups
GN305_RS09545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN305_RS09545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GN305_RS09550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN305_RS09550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GN305_RS09565	COG2226	methyltransferase
GN305_RS09580	COG0004	ammonium transporteR
GN305_RS09585	COG0347	Belongs to the P(II) protein family
GN305_RS09595	COG0436	Aminotransferase
GN305_RS09600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GN305_RS09605	COG1119	ATPase activity
GN305_RS09610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GN305_RS09615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GN305_RS09630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GN305_RS09635	COG0252	asparaginase activity
GN305_RS09665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GN305_RS09670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GN305_RS09675	COG0363	glucosamine-6-phosphate deaminase activity
GN305_RS09685	COG1271	oxidase subunit
GN305_RS09700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS09705	COG1136	(ABC) transporter
GN305_RS09710	COG0577	efflux transmembrane transporter activity
GN305_RS09710	COG1136	(ABC) transporter
GN305_RS09720	COG3279	Response regulator of the LytR AlgR family
GN305_RS09735	COG4566	intracellular signal transduction
GN305_RS09740	COG0247	lactate metabolic process
GN305_RS09745	COG1139	Iron-sulfur cluster binding protein
GN305_RS09760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GN305_RS09785	COG0259	pyridoxamine-phosphate oxidase activity
GN305_RS09795	COG1918	ferrous iron import across plasma membrane
GN305_RS09795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GN305_RS09810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GN305_RS09815	COG0497	DNA recombination
GN305_RS09845	COG0297	glycogen (starch) synthase activity
GN305_RS09850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GN305_RS09855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GN305_RS09860	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GN305_RS09870	COG2816	NAD+ diphosphatase activity
GN305_RS09875	COG2183	response to ionizing radiation
GN305_RS09880	COG3250	beta-galactosidase activity
GN305_RS09885	COG0745	RESPONSE REGULATOR receiver
GN305_RS09885	COG2205	protein histidine kinase activity
GN305_RS09885	COG3292	Two component regulator propeller
GN305_RS09895	COG4206	TonB-dependent receptor
GN305_RS09895	COG1629	transport
GN305_RS09935	COG4771	TonB-dependent receptor
GN305_RS09950	COG1629	transport
GN305_RS09980	COG5012	cobalamin binding
GN305_RS09985	COG1501	Belongs to the glycosyl hydrolase 31 family
GN305_RS10000	COG0251	oxidation-reduction process
GN305_RS10025	COG0488	(ABC) transporter
GN305_RS10045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GN305_RS10065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GN305_RS10070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GN305_RS10090	COG1215	transferase activity, transferring glycosyl groups
GN305_RS10095	COG0297	glycogen (starch) synthase activity
GN305_RS10150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GN305_RS10160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GN305_RS10175	COG1678	Uncharacterized ACR, COG1678
GN305_RS10185	COG2205	protein histidine kinase activity
GN305_RS10185	COG0745	RESPONSE REGULATOR receiver
GN305_RS10185	COG3292	Two component regulator propeller
GN305_RS10185	COG0745	RESPONSE REGULATOR receiver
GN305_RS10185	COG3292	Two component regulator propeller
GN305_RS10185	COG2205	protein histidine kinase activity
GN305_RS10195	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GN305_RS10200	COG1151	hydroxylamine reductase activity
GN305_RS10210	COG3119	arylsulfatase activity
GN305_RS10220	COG0745	RESPONSE REGULATOR receiver
GN305_RS10225	COG5002	protein histidine kinase activity
GN305_RS10245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GN305_RS10250	COG0248	Ppx GppA phosphatase
GN305_RS10260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GN305_RS10275	COG0356	it plays a direct role in the translocation of protons across the membrane
GN305_RS10280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN305_RS10285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GN305_RS10290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN305_RS10295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GN305_RS10300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GN305_RS10315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GN305_RS10325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GN305_RS10330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GN305_RS10350	COG3973	AAA domain
GN305_RS10355	COG2855	membrane
GN305_RS10375	COG1979	alcohol dehydrogenase
GN305_RS10380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GN305_RS10400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GN305_RS10400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GN305_RS10405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GN305_RS10410	COG0357	Ribosomal RNA small subunit methyltransferase G
GN305_RS10420	COG2217	Heavy metal translocating P-type atpase
GN305_RS10435	COG0321	lipoyl(octanoyl) transferase activity
GN305_RS10440	COG1022	Amp-dependent synthetase and ligase
GN305_RS10445	COG1252	NADH dehydrogenase
GN305_RS10475	COG3617	BRO family, N-terminal domain
GN305_RS10495	COG4974	Belongs to the 'phage' integrase family
GN305_RS10535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GN305_RS10540	COG1523	belongs to the glycosyl hydrolase 13 family
GN305_RS10545	COG1312	Catalyzes the dehydration of D-mannonate
GN305_RS10550	COG1752	Esterase of the alpha-beta hydrolase superfamily
GN305_RS10555	COG2176	DNA-directed DNA polymerase activity
GN305_RS10560	COG1739	Uncharacterized protein family UPF0029
GN305_RS10570	COG0556	nucleotide-excision repair
GN305_RS10595	COG3942	CHAP domain
GN305_RS10595	COG1388	LysM domain
GN305_RS10605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GN305_RS10610	COG3104	oligopeptide transport
GN305_RS10615	COG2431	L-lysine efflux transmembrane transporter activity
GN305_RS10630	COG1757	Na H antiporter
GN305_RS10635	COG2721	sulfolactate sulfo-lyase activity
GN305_RS10640	COG1609	Transcriptional regulator
GN305_RS10655	COG0501	Belongs to the peptidase M48B family
GN305_RS10665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GN305_RS10675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GN305_RS10690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GN305_RS10730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GN305_RS10745	COG1904	glucuronate isomerase
GN305_RS10750	COG0246	Mannitol dehydrogenase
GN305_RS10770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GN305_RS10775	COG1120	ATPase activity
GN305_RS10780	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GN305_RS10810	COG2207	Transcriptional regulator
GN305_RS10810	COG0662	Cupin 2, conserved barrel domain protein
GN305_RS10815	COG4753	response regulator
GN305_RS10815	COG2207	Transcriptional regulator
GN305_RS10820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GN305_RS10830	COG4771	TonB-dependent receptor
GN305_RS10840	COG4771	TonB-dependent receptor
GN305_RS10845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GN305_RS10850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GN305_RS10855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GN305_RS10875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN305_RS10885	COG0439	Biotin carboxylase
GN305_RS10910	COG4771	TonB-dependent receptor
GN305_RS10915	COG4771	TonB-dependent receptor
GN305_RS10925	COG1797	cobyrinic acid a,c-diamide synthase activity
GN305_RS10930	COG2096	Adenosyltransferase
GN305_RS10935	COG1492	cobalamin metabolic process
GN305_RS10945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GN305_RS10970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GN305_RS11005	COG0513	Belongs to the DEAD box helicase family
GN305_RS11010	COG0560	Phosphoserine phosphatase
GN305_RS11010	COG3830	Belongs to the UPF0237 family
GN305_RS11020	COG1011	Hydrolase
GN305_RS11030	COG0343	queuine tRNA-ribosyltransferase activity
GN305_RS11035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GN305_RS11040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GN305_RS11045	COG1597	lipid kinase activity
GN305_RS11050	COG0156	8-amino-7-oxononanoate synthase activity
GN305_RS11065	COG1136	(ABC) transporter
GN305_RS11110	COG3852	Histidine kinase
GN305_RS11120	COG4771	TonB-dependent receptor
GN305_RS11140	COG2814	Major facilitator Superfamily
GN305_RS11190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GN305_RS11195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GN305_RS11235	COG3579	cysteine-type endopeptidase activity
GN305_RS11250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN305_RS11275	COG0728	peptidoglycan biosynthetic process
GN305_RS11285	COG1216	Glycosyl transferase, family 2
GN305_RS11285	COG1442	glycosyl transferase family 8
GN305_RS11295	COG1216	Glycosyl transferase, family 2
GN305_RS11305	COG0438	transferase activity, transferring glycosyl groups
GN305_RS11320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GN305_RS11350	COG1805	sodium ion transport
GN305_RS11355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN305_RS11360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN305_RS11365	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN305_RS11375	COG0513	Belongs to the DEAD box helicase family
GN305_RS11380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GN305_RS11385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GN305_RS11400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS11415	COG0561	phosphatase activity
GN305_RS11425	COG1285	pathogenesis
GN305_RS11435	COG2205	protein histidine kinase activity
GN305_RS11445	COG0494	nUDIX hydrolase
GN305_RS11455	COG1733	regulation of RNA biosynthetic process
GN305_RS11460	COG4106	trans-aconitate 2-methyltransferase activity
GN305_RS11475	COG3387	PFAM Glycoside hydrolase 15-related
GN305_RS11495	COG2205	protein histidine kinase activity
GN305_RS11495	COG2198	Histidine kinase
GN305_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS11495	COG0784	Response regulator, receiver
GN305_RS11520	COG0778	Nitroreductase
GN305_RS11555	COG4974	Belongs to the 'phage' integrase family
GN305_RS11575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GN305_RS11580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GN305_RS11585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GN305_RS11595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GN305_RS11600	COG2204	response regulator
GN305_RS11610	COG4176	ABC-type proline glycine betaine transport system permease component
GN305_RS11620	COG0697	spore germination
GN305_RS11625	COG0110	maltose O-acetyltransferase activity
GN305_RS11635	COG0024	Methionine aminopeptidase
GN305_RS11640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GN305_RS11650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GN305_RS11655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GN305_RS11665	COG0552	protein localization to endoplasmic reticulum
GN305_RS11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN305_RS11675	COG0776	regulation of translation
GN305_RS11680	COG0776	regulation of translation
GN305_RS11685	COG0714	Associated with various cellular activities
GN305_RS11700	COG2304	oxidoreductase activity
GN305_RS11725	COG0671	phosphoesterase, PA-phosphatase related
GN305_RS11750	COG0542	response to heat
GN305_RS11760	COG1752	Esterase of the alpha-beta hydrolase superfamily
GN305_RS11780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GN305_RS11785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GN305_RS11790	COG0336	Belongs to the RNA methyltransferase TrmD family
GN305_RS11795	COG0167	dihydroorotate dehydrogenase activity
GN305_RS11800	COG0543	2 iron, 2 sulfur cluster binding
GN305_RS11815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GN305_RS11830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GN305_RS11840	COG0390	transport system, permease component
GN305_RS11845	COG1131	(ABC) transporter
GN305_RS11850	COG0442	prolyl-tRNA aminoacylation
GN305_RS11860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GN305_RS11890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GN305_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS11915	COG1131	(ABC) transporter
GN305_RS11920	COG0842	Transport permease protein
GN305_RS11925	COG0842	Transport permease protein
GN305_RS11925	COG1129	ABC transporter
GN305_RS11930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GN305_RS11945	COG0540	Belongs to the ATCase OTCase family
GN305_RS11950	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GN305_RS11965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GN305_RS11970	COG0534	Mate efflux family protein
GN305_RS11975	COG2885	chlorophyll binding
GN305_RS11980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GN305_RS12015	COG0504	CTP synthase activity
GN305_RS12020	COG0706	membrane insertase activity
GN305_RS12025	COG1506	peptidase
GN305_RS12025	COG0823	Involved in the tonB-independent uptake of proteins
GN305_RS12030	COG0564	pseudouridine synthase activity
GN305_RS12035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GN305_RS12040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GN305_RS12040	COG0574	Belongs to the PEP-utilizing enzyme family
GN305_RS12045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GN305_RS12060	COG1136	(ABC) transporter
GN305_RS12060	COG0577	efflux transmembrane transporter activity
GN305_RS12070	COG0339	signal peptide processing
GN305_RS12090	COG0438	transferase activity, transferring glycosyl groups
GN305_RS12120	COG1216	Glycosyl transferase, family 2
GN305_RS12145	COG0386	Belongs to the glutathione peroxidase family
GN305_RS12155	COG4191	Histidine kinase
GN305_RS12170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GN305_RS12175	COG0305	Participates in initiation and elongation during chromosome replication
GN305_RS12180	COG0072	phenylalanine-tRNA ligase activity
GN305_RS12180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN305_RS12185	COG0217	transcriptional regulatory protein
GN305_RS12205	COG0577	efflux transmembrane transporter activity
GN305_RS12210	COG0577	efflux transmembrane transporter activity
GN305_RS12210	COG1136	(ABC) transporter
GN305_RS12230	COG3852	Histidine kinase
GN305_RS12235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GN305_RS12235	COG3153	acetyltransferase
GN305_RS12295	COG0352	thiamine-phosphate diphosphorylase activity
GN305_RS12300	COG2022	thiamine diphosphate biosynthetic process
GN305_RS12305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GN305_RS12325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GN305_RS12330	COG0754	glutathionylspermidine amidase activity
GN305_RS12340	COG0352	thiamine-phosphate diphosphorylase activity
GN305_RS12345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GN305_RS12355	COG1177	transmembrane transport
GN305_RS12380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS12385	COG0058	SHG alpha-glucan phosphorylase activity
GN305_RS12395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN305_RS12400	COG1269	ATP hydrolysis coupled proton transport
GN305_RS12415	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GN305_RS12465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS12500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GN305_RS12505	COG1597	lipid kinase activity
GN305_RS12510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GN305_RS12520	COG1970	mechanosensitive ion channel activity
GN305_RS12525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GN305_RS12525	COG0519	Catalyzes the synthesis of GMP from XMP
GN305_RS12530	COG0519	Catalyzes the synthesis of GMP from XMP
GN305_RS12545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS12575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS12590	COG3119	arylsulfatase activity
GN305_RS12635	COG4206	TonB-dependent receptor
GN305_RS12635	COG1629	transport
GN305_RS12655	COG1595	DNA-templated transcription, initiation
GN305_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
GN305_RS12700	COG2211	Major facilitator Superfamily
GN305_RS12750	COG1408	metallophosphoesterase
GN305_RS12755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GN305_RS12770	COG1674	ftsk spoiiie
GN305_RS12780	COG0492	ferredoxin-NADP+ reductase activity
GN305_RS12785	COG0612	Peptidase, M16
GN305_RS12795	COG1131	(ABC) transporter
GN305_RS12800	COG0791	NLP P60 protein
GN305_RS12805	COG0546	phosphoglycolate phosphatase activity
GN305_RS12810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GN305_RS12815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GN305_RS12830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GN305_RS12840	COG0543	2 iron, 2 sulfur cluster binding
GN305_RS12860	COG0037	tRNA processing
GN305_RS12875	COG4864	UPF0365 protein
GN305_RS12880	COG0813	purine-nucleoside phosphorylase activity
GN305_RS12890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GN305_RS13130	COG1388	LysM domain
GN305_RS13130	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN305_RS13200	COG0739	heme binding
GN305_RS13200	COG0741	lytic transglycosylase activity
GN305_RS13200	COG1196	nuclear chromosome segregation
GN305_RS13220	COG3279	Response regulator of the LytR AlgR family
GN305_RS13250	COG0629	single-stranded DNA binding
GN305_RS13265	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GN305_RS13285	COG1192	Involved in chromosome partitioning
GN305_RS13300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GN305_RS13485	COG4974	Belongs to the 'phage' integrase family
GN305_RS13490	COG0582	viral genome integration into host DNA
GN305_RS13495	COG4974	Belongs to the 'phage' integrase family
GN305_RS13580	COG0202	RNA polymerase activity
GN305_RS13590	COG3344	reverse transcriptase
GN305_RS13645	COG4974	Belongs to the 'phage' integrase family
GN305_RS13660	COG3344	reverse transcriptase
GN305_RS13685	COG4771	TonB-dependent receptor
GN305_RS13750	COG1063	alcohol dehydrogenase
GN305_RS13765	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS13770	COG0346	lactoylglutathione lyase activity
GN305_RS13785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GN305_RS13810	COG0564	pseudouridine synthase activity
GN305_RS13815	COG0534	Mate efflux family protein
GN305_RS13835	COG1538	Outer membrane efflux protein
GN305_RS13915	COG3279	Response regulator of the LytR AlgR family
GN305_RS13920	COG3275	phosphorelay sensor kinase activity
GN305_RS13935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GN305_RS13945	COG0739	heme binding
GN305_RS13950	COG0686	Belongs to the AlaDH PNT family
GN305_RS13955	COG0805	protein transport
GN305_RS13960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GN305_RS13980	COG2855	membrane
GN305_RS13985	COG0583	DNA-binding transcription factor activity
GN305_RS13995	COG0542	response to heat
GN305_RS14015	COG1862	Preprotein translocase
GN305_RS14020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GN305_RS14030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GN305_RS14035	COG0193	aminoacyl-tRNA hydrolase activity
GN305_RS14040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GN305_RS14050	COG4651	solute:proton antiporter activity
GN305_RS14050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GN305_RS14055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GN305_RS14060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN305_RS14065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GN305_RS14070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GN305_RS14080	COG3292	Two component regulator propeller
GN305_RS14080	COG0745	RESPONSE REGULATOR receiver
GN305_RS14080	COG2205	protein histidine kinase activity
GN305_RS14095	COG5146	pantothenate kinase activity
GN305_RS14165	COG0656	L-ascorbic acid biosynthetic process
GN305_RS14170	COG0656	L-ascorbic acid biosynthetic process
GN305_RS14175	COG0656	L-ascorbic acid biosynthetic process
GN305_RS14180	COG3250	beta-galactosidase activity
GN305_RS14240	COG0805	protein transport
GN305_RS14245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GN305_RS14260	COG0655	NAD(P)H dehydrogenase (quinone) activity
GN305_RS14285	COG0667	Aldo Keto reductase
GN305_RS14290	COG2311	Membrane
GN305_RS14295	COG0697	spore germination
GN305_RS14310	COG0667	Aldo Keto reductase
GN305_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS14345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GN305_RS14350	COG0534	Mate efflux family protein
GN305_RS14375	COG0656	L-ascorbic acid biosynthetic process
GN305_RS14385	COG0667	Aldo Keto reductase
GN305_RS14405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GN305_RS14490	COG0515	serine threonine protein kinase
GN305_RS14490	COG2815	serine threonine protein kinase
GN305_RS14595	COG4474	Belongs to the UPF0398 family
GN305_RS14635	COG4974	Belongs to the 'phage' integrase family
GN305_RS14640	COG4974	Belongs to the 'phage' integrase family
GN305_RS14690	COG2204	response regulator
GN305_RS14695	COG2198	Histidine kinase
GN305_RS14695	COG5002	protein histidine kinase activity
GN305_RS14695	COG0784	Response regulator, receiver
GN305_RS14700	COG0805	protein transport
GN305_RS14705	COG1472	Belongs to the glycosyl hydrolase 3 family
GN305_RS14715	COG2942	2-epimerase
GN305_RS14720	COG2211	Major facilitator Superfamily
GN305_RS14725	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GN305_RS14730	COG4124	Belongs to the glycosyl hydrolase 26 family
GN305_RS14740	COG0702	epimerase
GN305_RS14745	COG4771	TonB-dependent receptor
GN305_RS14750	COG3458	cephalosporin-C deacetylase activity
GN305_RS14795	COG0788	formyltetrahydrofolate deformylase activity
GN305_RS14805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GN305_RS14810	COG0107	imidazoleglycerol-phosphate synthase activity
GN305_RS14815	COG0140	phosphoribosyl-ATP diphosphatase activity
GN305_RS14815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GN305_RS14820	COG2884	Cell division ATP-binding protein ftsE
GN305_RS14825	COG0527	aspartate kinase activity
GN305_RS14830	COG0019	diaminopimelate decarboxylase activity
GN305_RS14855	COG2431	L-lysine efflux transmembrane transporter activity
GN305_RS14865	COG0436	Aminotransferase
GN305_RS14880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GN305_RS14885	COG0167	dihydroorotate dehydrogenase activity
GN305_RS14935	COG1027	Aspartate ammonia-lyase
GN305_RS14940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GN305_RS14950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GN305_RS14960	COG4657	Part of a membrane complex involved in electron transport
GN305_RS14965	COG4660	Part of a membrane complex involved in electron transport
GN305_RS14970	COG4659	FMN binding
GN305_RS14975	COG4658	electron transport chain
GN305_RS14980	COG4656	Part of a membrane complex involved in electron transport
GN305_RS14995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GN305_RS15000	COG0697	spore germination
GN305_RS15010	COG0076	glutamate decarboxylase activity
GN305_RS15015	COG2066	Belongs to the glutaminase family
GN305_RS15020	COG3142	Participates in the control of copper homeostasis
GN305_RS15035	COG0531	amino acid
GN305_RS15040	COG5002	protein histidine kinase activity
GN305_RS15045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GN305_RS15050	COG0481	GTPase activity
GN305_RS15070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GN305_RS15075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GN305_RS15140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GN305_RS15145	COG0297	glycogen (starch) synthase activity
GN305_RS15170	COG3754	Rhamnan synthesis protein F
GN305_RS15185	COG0438	transferase activity, transferring glycosyl groups
GN305_RS15190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GN305_RS15240	COG4974	Belongs to the 'phage' integrase family
GN305_RS15380	COG3344	reverse transcriptase
GN305_RS15535	COG3196	Protein conserved in bacteria
GN305_RS15540	COG4974	Belongs to the 'phage' integrase family
GN305_RS15560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN305_RS15560	COG0551	DNA topoisomerase type I activity
GN305_RS15575	COG4804	nuclease activity
GN305_RS15605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GN305_RS15625	COG0573	inorganic phosphate transmembrane transporter activity
GN305_RS15630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GN305_RS15635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GN305_RS15650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GN305_RS15655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN305_RS15660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GN305_RS15670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN305_RS15695	COG2115	Belongs to the xylose isomerase family
GN305_RS15710	COG3292	Two component regulator propeller
GN305_RS15710	COG2205	protein histidine kinase activity
GN305_RS15710	COG0745	RESPONSE REGULATOR receiver
GN305_RS15715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN305_RS15735	COG1215	transferase activity, transferring glycosyl groups
GN305_RS15760	COG1216	Glycosyl transferase, family 2
GN305_RS15765	COG1216	Glycosyl transferase, family 2
GN305_RS15785	COG0438	transferase activity, transferring glycosyl groups
GN305_RS15795	COG1215	transferase activity, transferring glycosyl groups
GN305_RS15815	COG0438	transferase activity, transferring glycosyl groups
GN305_RS15825	COG1216	Glycosyl transferase, family 2
GN305_RS15825	COG1442	glycosyl transferase family 8
GN305_RS15830	COG0438	transferase activity, transferring glycosyl groups
GN305_RS15835	COG0463	Glycosyl transferase, family 2
GN305_RS15840	COG0745	RESPONSE REGULATOR receiver
GN305_RS15845	COG0784	Response regulator, receiver
GN305_RS15845	COG2205	protein histidine kinase activity
GN305_RS15860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN305_RS15865	COG0351	phosphomethylpyrimidine kinase
GN305_RS15865	COG0352	thiamine-phosphate diphosphorylase activity
GN305_RS15870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GN305_RS15880	COG0366	Alpha amylase catalytic
GN305_RS15895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GN305_RS15900	COG0071	Belongs to the small heat shock protein (HSP20) family
GN305_RS15915	COG0505	Belongs to the CarA family
GN305_RS15925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GN305_RS15930	COG0070	glutamate synthase
GN305_RS15930	COG0069	glutamate synthase activity
GN305_RS15930	COG0067	glutamate synthase
GN305_RS15940	COG0367	asparagine synthase
GN305_RS15985	COG5433	transposase activity
GN305_RS16005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GN305_RS16020	COG0438	transferase activity, transferring glycosyl groups
GN305_RS16040	COG0438	transferase activity, transferring glycosyl groups
GN305_RS16080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN305_RS16140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GN305_RS16150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GN305_RS16155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GN305_RS16160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GN305_RS16165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GN305_RS16175	COG0242	peptide deformylase activity
GN305_RS16180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GN305_RS16225	COG4946	Tricorn protease homolog
GN305_RS16225	COG1506	peptidase
GN305_RS16225	COG0823	Involved in the tonB-independent uptake of proteins
GN305_RS16230	COG0477	Major facilitator Superfamily
GN305_RS16230	COG2814	Major facilitator Superfamily
GN305_RS16255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS16285	COG0133	tryptophan synthase activity
GN305_RS16290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GN305_RS16295	COG0512	Glutamine amidotransferase of anthranilate synthase
GN305_RS16300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GN305_RS16305	COG0134	indole-3-glycerol-phosphate synthase activity
GN305_RS16310	COG0135	phosphoribosylanthranilate isomerase activity
GN305_RS16315	COG0159	tryptophan synthase activity
GN305_RS16320	COG0252	asparaginase activity
GN305_RS16325	COG0745	RESPONSE REGULATOR receiver
GN305_RS16330	COG5002	protein histidine kinase activity
GN305_RS16345	COG0629	single-stranded DNA binding
GN305_RS16355	COG0776	regulation of translation
GN305_RS16360	COG1530	ribonuclease E activity
GN305_RS16370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN305_RS16380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GN305_RS16385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GN305_RS16390	COG0166	Belongs to the GPI family
GN305_RS16395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GN305_RS16405	COG0702	epimerase
GN305_RS16410	COG4771	TonB-dependent receptor
GN305_RS16425	COG1940	carbohydrate kinase activity
GN305_RS16440	COG2271	Major facilitator Superfamily
GN305_RS16445	COG0363	glucosamine-6-phosphate deaminase activity
GN305_RS16450	COG0363	glucosamine-6-phosphate deaminase activity
GN305_RS16460	COG1917	Cupin 2, conserved barrel domain protein
GN305_RS16460	COG4977	sequence-specific DNA binding
GN305_RS16465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS16525	COG0745	RESPONSE REGULATOR receiver
GN305_RS16535	COG3250	beta-galactosidase activity
GN305_RS16545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS16555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS16575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS16590	COG4206	TonB-dependent receptor
GN305_RS16590	COG1629	transport
GN305_RS16600	COG2502	aspartate--ammonia ligase
GN305_RS16605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GN305_RS16620	COG3876	Protein conserved in bacteria
GN305_RS16635	COG1132	(ABC) transporter
GN305_RS16655	COG0732	type I restriction modification DNA specificity domain
GN305_RS16665	COG0732	type I restriction modification DNA specificity domain
GN305_RS16675	COG4974	Belongs to the 'phage' integrase family
GN305_RS16680	COG0582	viral genome integration into host DNA
GN305_RS16685	COG4974	Belongs to the 'phage' integrase family
GN305_RS16695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GN305_RS16770	COG0860	N-Acetylmuramoyl-L-alanine amidase
GN305_RS16780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GN305_RS16785	COG0778	Nitroreductase
GN305_RS16800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GN305_RS16815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN305_RS16820	COG0318	PFAM AMP-dependent synthetase and ligase
GN305_RS16830	COG0359	binds to the 23S rRNA
GN305_RS16835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GN305_RS16840	COG0360	Binds together with S18 to 16S ribosomal RNA
GN305_RS16865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GN305_RS16870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GN305_RS16920	COG3661	Belongs to the glycosyl hydrolase 67 family
GN305_RS16930	COG3507	Belongs to the glycosyl hydrolase 43 family
GN305_RS16935	COG0745	RESPONSE REGULATOR receiver
GN305_RS16935	COG2205	protein histidine kinase activity
GN305_RS16935	COG3292	Two component regulator propeller
GN305_RS16945	COG1629	transport
GN305_RS16945	COG4206	TonB-dependent receptor
GN305_RS16950	COG3507	Belongs to the glycosyl hydrolase 43 family
GN305_RS16965	COG2211	Major facilitator Superfamily
GN305_RS16975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GN305_RS16985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GN305_RS16990	COG2333	competence protein COMEC
GN305_RS16990	COG0658	competence protein
GN305_RS16995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GN305_RS17015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GN305_RS17025	COG0009	L-threonylcarbamoyladenylate synthase
GN305_RS17080	COG0745	RESPONSE REGULATOR receiver
GN305_RS17080	COG0745	RESPONSE REGULATOR receiver
GN305_RS17080	COG2205	protein histidine kinase activity
GN305_RS17080	COG3292	Two component regulator propeller
GN305_RS17080	COG3292	Two component regulator propeller
GN305_RS17080	COG2205	protein histidine kinase activity
GN305_RS17085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GN305_RS17120	COG0681	Belongs to the peptidase S26 family
GN305_RS17185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GN305_RS17200	COG1280	lysine exporter protein (LysE YggA)
GN305_RS17205	COG0047	phosphoribosylformylglycinamidine synthase activity
GN305_RS17205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GN305_RS17210	COG3292	Two component regulator propeller
GN305_RS17210	COG2205	protein histidine kinase activity
GN305_RS17210	COG0745	RESPONSE REGULATOR receiver
GN305_RS17215	COG2059	Chromate
GN305_RS17230	COG1501	Belongs to the glycosyl hydrolase 31 family
GN305_RS17235	COG1649	PFAM Uncharacterised BCR, COG1649
GN305_RS17250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS17265	COG1966	Carbon starvation protein
GN305_RS17275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GN305_RS17280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GN305_RS17285	COG0284	orotidine-5'-phosphate decarboxylase activity
GN305_RS17290	COG1078	dGTPase activity
GN305_RS17295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN305_RS17300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GN305_RS17300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GN305_RS17305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN305_RS17315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GN305_RS17335	COG0386	Belongs to the glutathione peroxidase family
GN305_RS17345	COG4206	TonB-dependent receptor
GN305_RS17345	COG1629	transport
GN305_RS17355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS17365	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS17380	COG2267	carboxylic ester hydrolase activity
GN305_RS17435	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS17450	COG1629	transport
GN305_RS17475	COG1472	Belongs to the glycosyl hydrolase 3 family
GN305_RS17485	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS17495	COG0702	epimerase
GN305_RS17500	COG1629	transport
GN305_RS17510	COG1082	Xylose isomerase domain protein TIM barrel
GN305_RS17520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS17525	COG0745	RESPONSE REGULATOR receiver
GN305_RS17525	COG2205	protein histidine kinase activity
GN305_RS17525	COG3292	Two component regulator propeller
GN305_RS17550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN305_RS17550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN305_RS17555	COG0436	Aminotransferase
GN305_RS17565	COG1472	Belongs to the glycosyl hydrolase 3 family
GN305_RS17570	COG0737	Belongs to the 5'-nucleotidase family
GN305_RS17575	COG0737	Belongs to the 5'-nucleotidase family
GN305_RS17580	COG0335	large ribosomal subunit rRNA binding
GN305_RS17590	COG3292	Two component regulator propeller
GN305_RS17590	COG2205	protein histidine kinase activity
GN305_RS17590	COG0745	RESPONSE REGULATOR receiver
GN305_RS17595	COG3254	rhamnose metabolic process
GN305_RS17600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN305_RS17605	COG3401	FG-GAP repeat protein
GN305_RS17635	COG0702	epimerase
GN305_RS17640	COG4771	TonB-dependent receptor
GN305_RS17665	COG2755	lipolytic protein G-D-S-L family
GN305_RS17670	COG3401	FG-GAP repeat protein
GN305_RS17675	COG3250	beta-galactosidase activity
GN305_RS17685	COG3119	arylsulfatase activity
GN305_RS17700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN305_RS17705	COG4206	TonB-dependent receptor
GN305_RS17705	COG1629	transport
GN305_RS17715	COG4771	TonB-dependent receptor
GN305_RS17725	COG4206	TonB-dependent receptor
GN305_RS17725	COG1629	transport
GN305_RS17740	COG4771	TonB-dependent receptor
GN305_RS17765	COG3401	FG-GAP repeat protein
GN305_RS17780	COG1874	Beta-galactosidase
GN305_RS17790	COG3250	beta-galactosidase activity
GN305_RS17795	COG2755	lipolytic protein G-D-S-L family
GN305_RS17835	COG3254	rhamnose metabolic process
GN305_RS17840	COG1940	carbohydrate kinase activity
GN305_RS17850	COG1136	(ABC) transporter
GN305_RS17850	COG0577	efflux transmembrane transporter activity
GN305_RS17855	COG1136	(ABC) transporter
GN305_RS17855	COG0577	efflux transmembrane transporter activity
GN305_RS17875	COG2996	Protein conserved in bacteria
GN305_RS17880	COG1979	alcohol dehydrogenase
GN305_RS17890	COG1136	(ABC) transporter
GN305_RS17895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GN305_RS17900	COG0589	response to stress
GN305_RS17900	COG0475	glutathione-regulated potassium exporter activity
GN305_RS17905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GN305_RS17915	COG0423	glycine-tRNA ligase activity
GN305_RS17970	COG0561	phosphatase activity
GN305_RS17975	COG4771	TonB-dependent receptor
GN305_RS17980	COG2207	Transcriptional regulator
GN305_RS17995	COG0738	Major facilitator superfamily
GN305_RS18000	COG1063	alcohol dehydrogenase
GN305_RS18005	COG2095	MarC family integral membrane protein
GN305_RS18040	COG1696	Membrane protein involved in D-alanine export
GN305_RS18065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS18095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS18105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GN305_RS18145	COG3969	phosphoadenosine phosphosulfate
GN305_RS18150	COG1475	DNA binding
GN305_RS18160	COG0039	L-malate dehydrogenase activity
GN305_RS18175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN305_RS18190	COG3015	lipoprotein NlpE involved in copper resistance
GN305_RS18205	COG0489	protein tyrosine kinase activity
GN305_RS18220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GN305_RS18225	COG1722	exodeoxyribonuclease VII activity
GN305_RS18230	COG1570	exodeoxyribonuclease VII activity
GN305_RS18240	COG0534	Mate efflux family protein
GN305_RS18300	COG0641	radical SAM
GN305_RS18380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GN305_RS18390	COG1088	dTDP-glucose 4,6-dehydratase activity
GN305_RS18395	COG1629	transport
GN305_RS18405	COG3250	beta-galactosidase activity
GN305_RS18410	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GN305_RS18410	COG3408	Glycogen debranching enzyme
GN305_RS18415	COG0702	epimerase
GN305_RS18420	COG4771	TonB-dependent receptor
GN305_RS18435	COG0488	(ABC) transporter
GN305_RS18440	COG0569	domain protein
GN305_RS18440	COG2985	domain, Protein
GN305_RS18445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN305_RS18450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN305_RS18450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN305_RS18460	COG1629	transport
GN305_RS18470	COG4206	TonB-dependent receptor
GN305_RS18470	COG1629	transport
GN305_RS18475	COG2205	protein histidine kinase activity
GN305_RS18480	COG0668	transmembrane transport
GN305_RS18515	COG2086	electron transfer activity
GN305_RS18520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GN305_RS18540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GN305_RS18550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GN305_RS18565	COG4974	Belongs to the 'phage' integrase family
GN305_RS18570	COG0582	viral genome integration into host DNA
GN305_RS18575	COG4974	Belongs to the 'phage' integrase family
GN305_RS18595	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GN305_RS18605	COG1228	amidohydrolase
GN305_RS18610	COG3404	Formiminotransferase-cyclodeaminase
GN305_RS18615	COG2986	histidine ammonia-lyase
GN305_RS18620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GN305_RS18630	COG0693	protein deglycase activity
GN305_RS18650	COG0673	inositol 2-dehydrogenase activity
GN305_RS18655	COG0288	reversible hydration of carbon dioxide
GN305_RS18675	COG0459	protein refolding
GN305_RS18680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GN305_RS18690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN305_RS18700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GN305_RS18705	COG0124	histidyl-tRNA synthetase
GN305_RS18710	COG1879	ABC-type sugar transport system periplasmic component
GN305_RS18725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GN305_RS18730	COG3958	Transketolase
GN305_RS18735	COG3959	Transketolase, thiamine diphosphate binding domain
GN305_RS18740	COG1349	DNA-binding transcription factor activity
GN305_RS18745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN305_RS18745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN305_RS18755	COG3292	Two component regulator propeller
GN305_RS18755	COG3292	Two component regulator propeller
GN305_RS18755	COG2205	protein histidine kinase activity
GN305_RS18755	COG2205	protein histidine kinase activity
GN305_RS18755	COG0745	RESPONSE REGULATOR receiver
GN305_RS18755	COG0745	RESPONSE REGULATOR receiver
GN305_RS18765	COG1629	transport
GN305_RS18825	COG4206	TonB-dependent receptor
GN305_RS18835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GN305_RS18845	COG0534	Mate efflux family protein
GN305_RS18850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS18850	COG2205	protein histidine kinase activity
GN305_RS18850	COG0784	Response regulator, receiver
GN305_RS18850	COG2198	Histidine kinase
GN305_RS18855	COG2204	response regulator
GN305_RS18865	COG0564	pseudouridine synthase activity
GN305_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS18885	COG3250	beta-galactosidase activity
GN305_RS18905	COG4206	TonB-dependent receptor
GN305_RS18905	COG1629	transport
GN305_RS18910	COG0513	Belongs to the DEAD box helicase family
GN305_RS18930	COG0482	sulfurtransferase activity
GN305_RS18935	COG2197	response regulator
GN305_RS18965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GN305_RS18980	COG3022	response to hydroperoxide
GN305_RS18985	COG2885	chlorophyll binding
GN305_RS18995	COG2895	sulfate adenylyltransferase (ATP) activity
GN305_RS19000	COG0175	sulfate reduction
GN305_RS19005	COG0529	Catalyzes the synthesis of activated sulfate
GN305_RS19010	COG3273	potassium ion transport
GN305_RS19010	COG0471	metal ion transport
GN305_RS19015	COG1218	3'(2'),5'-bisphosphate nucleotidase
GN305_RS19025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GN305_RS19055	COG0517	IMP dehydrogenase activity
GN305_RS19055	COG0516	GMP reductase activity
GN305_RS19065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GN305_RS19070	COG0740	serine-type endopeptidase activity
GN305_RS19075	COG0544	peptidyl-prolyl cis-trans isomerase activity
GN305_RS19080	COG0724	RNA recognition motif
GN305_RS19090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GN305_RS19095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GN305_RS19100	COG1160	GTP binding
GN305_RS19105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GN305_RS19110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GN305_RS19165	COG0039	L-malate dehydrogenase activity
GN305_RS19170	COG0358	DNA primase activity
GN305_RS19175	COG0302	gtp cyclohydrolase
GN305_RS19195	COG0739	heme binding
GN305_RS19200	COG0105	UTP biosynthetic process
GN305_RS19205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GN305_RS19210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GN305_RS19225	COG0848	biopolymer transport protein
GN305_RS19230	COG0811	peptide transport
GN305_RS19235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GN305_RS19240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GN305_RS19270	COG0420	3'-5' exonuclease activity
GN305_RS19280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN305_RS19285	COG4206	TonB-dependent receptor
GN305_RS19285	COG1629	transport
GN305_RS19290	COG4977	sequence-specific DNA binding
GN305_RS19310	COG3408	Glycogen debranching enzyme
GN305_RS19315	COG0702	epimerase
GN305_RS19320	COG4771	TonB-dependent receptor
GN305_RS19335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GN305_RS19340	COG4771	TonB-dependent receptor
GN305_RS19345	COG0702	epimerase
GN305_RS19360	COG3507	Belongs to the glycosyl hydrolase 43 family
GN305_RS19370	COG4771	TonB-dependent receptor
GN305_RS19380	COG1629	transport
GN305_RS19380	COG4206	TonB-dependent receptor
GN305_RS19385	COG0745	RESPONSE REGULATOR receiver
GN305_RS19385	COG3292	Two component regulator propeller
GN305_RS19385	COG2205	protein histidine kinase activity
GN305_RS19405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GN305_RS19410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GN305_RS19415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GN305_RS19430	COG1346	cytolysis
GN305_RS19440	COG0280	phosphate acetyltransferase
GN305_RS19445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GN305_RS19450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN305_RS19455	COG2151	metal-sulfur cluster biosynthetic enzyme
GN305_RS19460	COG2003	Belongs to the UPF0758 family
GN305_RS19465	COG1216	Glycosyl transferase, family 2
GN305_RS19465	COG0463	Glycosyl transferase, family 2
GN305_RS19470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GN305_RS19475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GN305_RS19480	COG0641	radical SAM
GN305_RS19510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN305_RS19515	COG3119	arylsulfatase activity
GN305_RS19520	COG0702	epimerase
GN305_RS19525	COG4771	TonB-dependent receptor
GN305_RS19530	COG0657	acetylesterase activity
GN305_RS19530	COG2755	lipolytic protein G-D-S-L family
GN305_RS19535	COG0745	RESPONSE REGULATOR receiver
GN305_RS19535	COG2205	protein histidine kinase activity
GN305_RS19535	COG3292	Two component regulator propeller
GN305_RS19555	COG0564	pseudouridine synthase activity
GN305_RS19560	COG1181	Belongs to the D-alanine--D-alanine ligase family
GN305_RS19580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GN305_RS19585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GN305_RS19590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GN305_RS19595	COG0561	phosphatase activity
GN305_RS19620	COG4206	TonB-dependent receptor
GN305_RS19620	COG1629	transport
GN305_RS19630	COG4771	TonB-dependent receptor
GN305_RS19640	COG4206	TonB-dependent receptor
GN305_RS19640	COG1629	transport
GN305_RS19660	COG4974	Belongs to the 'phage' integrase family
GN305_RS19665	COG0582	viral genome integration into host DNA
GN305_RS19670	COG4974	Belongs to the 'phage' integrase family
GN305_RS19675	COG1629	transport
GN305_RS19675	COG4206	TonB-dependent receptor
GN305_RS19705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GN305_RS19710	COG1396	sequence-specific DNA binding
GN305_RS19710	COG1917	Cupin 2, conserved barrel domain protein
GN305_RS19725	COG0348	domain, Protein
GN305_RS19735	COG1368	sulfuric ester hydrolase activity
GN305_RS19740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GN305_RS19745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GN305_RS19750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GN305_RS19755	COG0137	argininosuccinate synthase activity
GN305_RS19765	COG1438	arginine binding
GN305_RS19770	COG1070	Carbohydrate kinase
GN305_RS19775	COG4806	L-rhamnose isomerase
GN305_RS19785	COG0235	Class ii aldolase
GN305_RS19800	COG0702	epimerase
GN305_RS19805	COG1629	transport
GN305_RS19805	COG4206	TonB-dependent receptor
GN305_RS19810	COG2205	protein histidine kinase activity
GN305_RS19810	COG0745	RESPONSE REGULATOR receiver
GN305_RS19810	COG3292	Two component regulator propeller
GN305_RS19820	COG1388	LysM domain
GN305_RS19820	COG0741	lytic transglycosylase activity
GN305_RS19825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GN305_RS19830	COG3250	beta-galactosidase activity
GN305_RS19850	COG0673	inositol 2-dehydrogenase activity
GN305_RS19865	COG0656	L-ascorbic acid biosynthetic process
GN305_RS19870	COG0656	L-ascorbic acid biosynthetic process
GN305_RS19875	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS19880	COG2249	NAD(P)H dehydrogenase (quinone) activity
GN305_RS19885	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GN305_RS19895	COG1082	Xylose isomerase domain protein TIM barrel
GN305_RS19905	COG4974	Belongs to the 'phage' integrase family
GN305_RS19910	COG0582	viral genome integration into host DNA
GN305_RS19915	COG4974	Belongs to the 'phage' integrase family
GN305_RS19935	COG4771	TonB-dependent receptor
GN305_RS19940	COG3537	Alpha-1,2-mannosidase
GN305_RS19970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GN305_RS19975	COG0542	response to heat
GN305_RS19980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GN305_RS19990	COG0534	Mate efflux family protein
GN305_RS20000	COG2197	response regulator
GN305_RS20005	COG3345	alpha-galactosidase
GN305_RS20010	COG4974	Belongs to the 'phage' integrase family
GN305_RS20060	COG0561	phosphatase activity
GN305_RS20065	COG4771	TonB-dependent receptor
GN305_RS20110	COG0702	epimerase
GN305_RS20115	COG1629	transport
GN305_RS20125	COG2205	protein histidine kinase activity
GN305_RS20125	COG3292	Two component regulator propeller
GN305_RS20125	COG2205	protein histidine kinase activity
GN305_RS20125	COG0745	RESPONSE REGULATOR receiver
GN305_RS20125	COG3292	Two component regulator propeller
GN305_RS20125	COG0745	RESPONSE REGULATOR receiver
GN305_RS20130	COG4948	Mandelate Racemase Muconate Lactonizing
GN305_RS20135	COG0457	Tetratricopeptide repeat
GN305_RS20140	COG2814	Major facilitator Superfamily
GN305_RS20150	COG3537	Alpha-1,2-mannosidase
GN305_RS20155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GN305_RS20155	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GN305_RS20185	COG1629	transport
GN305_RS20185	COG4206	TonB-dependent receptor
GN305_RS20200	COG2873	o-acetylhomoserine
GN305_RS20215	COG1595	DNA-templated transcription, initiation
GN305_RS20250	COG0203	ribosomal protein L17
GN305_RS20255	COG0202	RNA polymerase activity
GN305_RS20260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GN305_RS20265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GN305_RS20270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GN305_RS20275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GN305_RS20280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GN305_RS20295	COG0200	Binds to the 23S rRNA
GN305_RS20300	COG1841	ribosomal large subunit assembly
GN305_RS20305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GN305_RS20310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GN305_RS20315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GN305_RS20320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GN305_RS20325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GN305_RS20330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GN305_RS20335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GN305_RS20340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GN305_RS20345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GN305_RS20350	COG0255	Belongs to the universal ribosomal protein uL29 family
GN305_RS20355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GN305_RS20360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GN305_RS20365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GN305_RS20370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GN305_RS20375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GN305_RS20380	COG0089	rRNA binding
GN305_RS20385	COG0088	Forms part of the polypeptide exit tunnel
GN305_RS20390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GN305_RS20395	COG0051	transcription antitermination factor activity, RNA binding
GN305_RS20400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GN305_RS20405	COG0049	tRNA binding
GN305_RS20410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GN305_RS20420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GN305_RS20425	COG0085	RNA polymerase activity
GN305_RS20430	COG0222	ribosome binding
GN305_RS20435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GN305_RS20440	COG0081	regulation of translation
GN305_RS20445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GN305_RS20465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GN305_RS20495	COG4974	Belongs to the 'phage' integrase family
GN305_RS20500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GN305_RS20510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GN305_RS20525	COG0745	RESPONSE REGULATOR receiver
GN305_RS20530	COG5002	protein histidine kinase activity
GN305_RS20540	COG0793	Belongs to the peptidase S41A family
GN305_RS20545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GN305_RS20580	COG0702	epimerase
GN305_RS20585	COG0584	glycerophosphoryl diester phosphodiesterase
GN305_RS20590	COG3537	Alpha-1,2-mannosidase
GN305_RS20610	COG0745	RESPONSE REGULATOR receiver
GN305_RS20610	COG2205	protein histidine kinase activity
GN305_RS20610	COG3292	Two component regulator propeller
GN305_RS20615	COG4206	TonB-dependent receptor
GN305_RS20615	COG1629	transport
GN305_RS20620	COG0702	epimerase
GN305_RS20640	COG3634	alkyl hydroperoxide reductase activity
GN305_RS20650	COG0148	phosphopyruvate hydratase activity
GN305_RS20675	COG3250	beta-galactosidase activity
GN305_RS20690	COG1629	transport
GN305_RS20690	COG4206	TonB-dependent receptor
GN305_RS20695	COG3292	Two component regulator propeller
GN305_RS20695	COG2205	protein histidine kinase activity
GN305_RS20695	COG0745	RESPONSE REGULATOR receiver
GN305_RS20735	COG3250	beta-galactosidase activity
GN305_RS20740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN305_RS20750	COG4974	Belongs to the 'phage' integrase family
GN305_RS20785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN305_RS20785	COG0551	DNA topoisomerase type I activity
GN305_RS20835	COG1022	Amp-dependent synthetase and ligase
GN305_RS20880	COG1519	Transferase
GN305_RS20885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GN305_RS20895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GN305_RS20900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GN305_RS20905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GN305_RS20940	COG4974	Belongs to the 'phage' integrase family
GN305_RS20945	COG3645	SOS response
GN305_RS20960	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GN305_RS21005	COG2096	Adenosyltransferase
GN305_RS21020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN305_RS21030	COG0439	Biotin carboxylase
GN305_RS21035	COG3189	MarR family transcriptional regulator
GN305_RS21165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GN305_RS21175	COG1185	polyribonucleotide nucleotidyltransferase activity
GN305_RS21180	COG1773	rubredoxin
GN305_RS21185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GN305_RS21190	COG0545	Peptidyl-prolyl cis-trans isomerase
GN305_RS21195	COG0545	Peptidyl-prolyl cis-trans isomerase
GN305_RS21205	COG1283	sodium-dependent phosphate transmembrane transporter activity
GN305_RS21210	COG1283	sodium-dependent phosphate transmembrane transporter activity
GN305_RS21215	COG0572	uridine kinase
GN305_RS21235	COG0006	proline dipeptidase activity
GN305_RS21250	COG0509	glycine decarboxylation via glycine cleavage system
GN305_RS21255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GN305_RS21260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GN305_RS21265	COG2066	Belongs to the glutaminase family
GN305_RS21270	COG0724	RNA recognition motif
GN305_RS21290	COG3063	Type IV pilus biogenesis stability protein PilW
GN305_RS21295	COG0756	dUTP diphosphatase activity
GN305_RS21315	COG2001	Belongs to the MraZ family
GN305_RS21320	COG0275	rRNA processing
GN305_RS21330	COG0768	penicillin binding
GN305_RS21335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GN305_RS21340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GN305_RS21345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GN305_RS21350	COG0772	Belongs to the SEDS family
GN305_RS21355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GN305_RS21360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GN305_RS21375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GN305_RS21385	COG1381	Involved in DNA repair and RecF pathway recombination
GN305_RS21395	COG0268	Binds directly to 16S ribosomal RNA
GN305_RS21400	COG0187	DNA topoisomerase II activity
GN305_RS21405	COG1640	4-alpha-glucanotransferase
GN305_RS21430	COG0366	Alpha amylase catalytic
GN305_RS21435	COG1082	Xylose isomerase domain protein TIM barrel
GN305_RS21445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN305_RS21455	COG4206	TonB-dependent receptor
GN305_RS21455	COG1629	transport
GN305_RS21460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN305_RS21475	COG0366	Alpha amylase catalytic
GN305_RS21505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GN305_RS21515	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
GN305_RS21520	COG0738	Major facilitator superfamily
GN305_RS21525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GN305_RS21535	COG4206	TonB-dependent receptor
GN305_RS21535	COG1629	transport
GN305_RS21540	COG0702	epimerase
GN305_RS21550	COG2431	L-lysine efflux transmembrane transporter activity
GN305_RS21555	COG3250	beta-galactosidase activity
GN305_RS21560	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GN305_RS21560	COG3408	Glycogen debranching enzyme
GN305_RS21565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GN305_RS21570	COG0719	Fe-S assembly protein
GN305_RS21575	COG0396	ATPase activity
GN305_RS21580	COG0719	Fe-S assembly protein
GN305_RS21590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GN305_RS21595	COG0195	Participates in both transcription termination and antitermination
GN305_RS21600	COG0779	Required for maturation of 30S ribosomal subunits
GN305_RS21610	COG2814	Major facilitator Superfamily
GN305_RS21635	COG3458	cephalosporin-C deacetylase activity
GN305_RS21655	COG1595	DNA-templated transcription, initiation
GN305_RS21660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GN305_RS21665	COG1166	arginine decarboxylase activity
GN305_RS21670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GN305_RS21695	COG1253	flavin adenine dinucleotide binding
GN305_RS21705	COG1522	sequence-specific DNA binding
GN305_RS21730	COG3426	butyrate kinase activity
GN305_RS21735	COG0280	phosphate acetyltransferase
GN305_RS21740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GN305_RS21750	COG2166	iron-sulfur cluster assembly
GN305_RS21775	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GN305_RS21840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GN305_RS21845	COG1011	Hydrolase
GN305_RS21850	COG0196	riboflavin kinase activity
GN305_RS21885	COG3655	Transcriptional regulator
GN305_RS21910	COG3591	Belongs to the peptidase S1B family
GN305_RS21925	COG2255	four-way junction helicase activity
GN305_RS21930	COG4974	Belongs to the 'phage' integrase family
GN305_RS22020	COG0482	sulfurtransferase activity
GN305_RS22025	COG0308	aminopeptidase N
GN305_RS22040	COG0517	IMP dehydrogenase activity
GN305_RS22040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GN305_RS22050	COG0612	Peptidase, M16
GN305_RS22060	COG0784	Response regulator, receiver
GN305_RS22060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN305_RS22060	COG2198	Histidine kinase
GN305_RS22060	COG2205	protein histidine kinase activity
GN305_RS22065	COG3119	arylsulfatase activity
GN305_RS22075	COG4771	TonB-dependent receptor
GN305_RS22080	COG1312	Catalyzes the dehydration of D-mannonate
GN305_RS22085	COG1028	Short-chain dehydrogenase reductase Sdr
GN305_RS22095	COG0681	Belongs to the peptidase S26 family
GN305_RS22100	COG0681	Belongs to the peptidase S26 family
GN305_RS22105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GN305_RS22120	COG0584	glycerophosphoryl diester phosphodiesterase
GN305_RS22130	COG1454	alcohol dehydrogenase
GN305_RS22150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GN305_RS22150	COG0758	DNA mediated transformation
GN305_RS22205	COG1053	succinate dehydrogenase
GN305_RS22220	COG3409	Peptidoglycan-binding domain 1 protein
GN305_RS22220	COG0793	Belongs to the peptidase S41A family
GN305_RS22225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GN305_RS22255	COG3279	Response regulator of the LytR AlgR family
GN305_RS22300	COG0700	Nucleoside recognition
GN305_RS22305	COG5002	protein histidine kinase activity
GN305_RS22310	COG0745	RESPONSE REGULATOR receiver
GN305_RS22330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GN305_RS22340	COG2268	Band 7 protein
GN305_RS22345	COG0445	tRNA wobble uridine modification