locus-tag	class	description
GN308_RS00005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GN308_RS00010	COG0322	excinuclease ABC activity
GN308_RS00015	COG1490	D-aminoacyl-tRNA deacylase activity
GN308_RS00020	COG1694	Mazg nucleotide pyrophosphohydrolase
GN308_RS00030	COG0142	geranyltranstransferase activity
GN308_RS00035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GN308_RS00035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GN308_RS00045	COG0012	GTP binding
GN308_RS00055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GN308_RS00095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GN308_RS00145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GN308_RS00155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GN308_RS00160	COG0594	ribonuclease P activity
GN308_RS00175	COG1611	Belongs to the LOG family
GN308_RS00180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GN308_RS00185	COG2814	Major facilitator Superfamily
GN308_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GN308_RS00210	COG1629	transport
GN308_RS00210	COG4206	TonB-dependent receptor
GN308_RS00260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GN308_RS00265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GN308_RS00270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GN308_RS00275	COG1968	undecaprenyl-diphosphatase activity
GN308_RS00285	COG2177	Part of the ABC transporter FtsEX involved in
GN308_RS00295	COG1983	PspC domain protein
GN308_RS00300	COG0545	Peptidyl-prolyl cis-trans isomerase
GN308_RS00305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN308_RS00315	COG0427	acetyl-CoA hydrolase
GN308_RS00320	COG1472	Belongs to the glycosyl hydrolase 3 family
GN308_RS00330	COG3119	arylsulfatase activity
GN308_RS00335	COG3119	arylsulfatase activity
GN308_RS00345	COG1629	transport
GN308_RS00345	COG4206	TonB-dependent receptor
GN308_RS00355	COG1595	DNA-templated transcription, initiation
GN308_RS00360	COG0793	Belongs to the peptidase S41A family
GN308_RS00360	COG4946	Tricorn protease homolog
GN308_RS00365	COG0702	epimerase
GN308_RS00375	COG3250	beta-galactosidase activity
GN308_RS00380	COG3292	Two component regulator propeller
GN308_RS00380	COG3292	Two component regulator propeller
GN308_RS00380	COG0745	RESPONSE REGULATOR receiver
GN308_RS00380	COG0745	RESPONSE REGULATOR receiver
GN308_RS00380	COG2205	protein histidine kinase activity
GN308_RS00380	COG2205	protein histidine kinase activity
GN308_RS00385	COG0495	leucyl-tRNA aminoacylation
GN308_RS00390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GN308_RS00400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GN308_RS00405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GN308_RS00425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GN308_RS00425	COG0731	radical SAM domain protein
GN308_RS00435	COG5002	protein histidine kinase activity
GN308_RS00470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GN308_RS00475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS00490	COG0659	secondary active sulfate transmembrane transporter activity
GN308_RS00500	COG1592	Rubrerythrin
GN308_RS00505	COG0745	RESPONSE REGULATOR receiver
GN308_RS00505	COG2205	protein histidine kinase activity
GN308_RS00505	COG3292	Two component regulator propeller
GN308_RS00520	COG1629	transport
GN308_RS00550	COG1629	transport
GN308_RS00550	COG4206	TonB-dependent receptor
GN308_RS00555	COG0702	epimerase
GN308_RS00565	COG4948	Mandelate Racemase Muconate Lactonizing
GN308_RS00595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GN308_RS00600	COG4974	Belongs to the 'phage' integrase family
GN308_RS00635	COG0551	DNA topoisomerase type I activity
GN308_RS00635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GN308_RS00655	COG2205	protein histidine kinase activity
GN308_RS00655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN308_RS00655	COG2198	Histidine kinase
GN308_RS00655	COG0784	Response regulator, receiver
GN308_RS00775	COG0358	DNA primase activity
GN308_RS00855	COG2027	D-alanyl-D-alanine carboxypeptidase
GN308_RS00860	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GN308_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS00870	COG4677	pectinesterase activity
GN308_RS00875	COG4771	TonB-dependent receptor
GN308_RS00880	COG0561	phosphatase activity
GN308_RS00895	COG0726	polysaccharide deacetylase
GN308_RS00925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GN308_RS00925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GN308_RS00945	COG1506	peptidase
GN308_RS00945	COG0823	Involved in the tonB-independent uptake of proteins
GN308_RS00950	COG0116	Belongs to the methyltransferase superfamily
GN308_RS00960	COG0583	DNA-binding transcription factor activity
GN308_RS00965	COG0783	Belongs to the Dps family
GN308_RS00975	COG4251	negative regulation of phosphorylation
GN308_RS00980	COG1045	serine acetyltransferase
GN308_RS00985	COG0557	exoribonuclease II activity
GN308_RS00990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GN308_RS01010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GN308_RS01015	COG0826	peptidase U32
GN308_RS01025	COG1629	transport
GN308_RS01030	COG0018	arginyl-trna synthetase
GN308_RS01035	COG0328	RNA-DNA hybrid ribonuclease activity
GN308_RS01035	COG3341	Caulimovirus viroplasmin
GN308_RS01045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GN308_RS01055	COG0463	Glycosyl transferase, family 2
GN308_RS01065	COG1215	transferase activity, transferring glycosyl groups
GN308_RS01075	COG1132	(ABC) transporter
GN308_RS01115	COG0562	UDP-galactopyranose mutase
GN308_RS01130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GN308_RS01190	COG4206	TonB-dependent receptor
GN308_RS01190	COG1629	transport
GN308_RS01200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GN308_RS01205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GN308_RS01210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN308_RS01215	COG0571	ribonuclease III activity
GN308_RS01220	COG3119	arylsulfatase activity
GN308_RS01235	COG3119	arylsulfatase activity
GN308_RS01250	COG4206	TonB-dependent receptor
GN308_RS01250	COG1629	transport
GN308_RS01255	COG2205	protein histidine kinase activity
GN308_RS01255	COG3292	Two component regulator propeller
GN308_RS01255	COG0745	RESPONSE REGULATOR receiver
GN308_RS01260	COG0205	6-phosphofructokinase activity
GN308_RS01335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GN308_RS01365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN308_RS01400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GN308_RS01405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GN308_RS01420	COG0215	cysteine-tRNA ligase activity
GN308_RS01440	COG1629	transport
GN308_RS01440	COG4206	TonB-dependent receptor
GN308_RS01445	COG1082	Xylose isomerase domain protein TIM barrel
GN308_RS01450	COG0745	RESPONSE REGULATOR receiver
GN308_RS01450	COG2205	protein histidine kinase activity
GN308_RS01450	COG3292	Two component regulator propeller
GN308_RS01455	COG3507	Belongs to the glycosyl hydrolase 43 family
GN308_RS01465	COG3119	arylsulfatase activity
GN308_RS01470	COG0482	sulfurtransferase activity
GN308_RS01480	COG3250	beta-galactosidase activity
GN308_RS01485	COG0776	regulation of translation
GN308_RS01505	COG0339	signal peptide processing
GN308_RS01510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GN308_RS01520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS01780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GN308_RS01845	COG3723	Recombinational DNA repair protein, rece pathway
GN308_RS01850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GN308_RS01910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GN308_RS01910	COG0674	pyruvate-flavodoxin oxidoreductase activity
GN308_RS01915	COG1013	pyruvate-flavodoxin oxidoreductase activity
GN308_RS01920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GN308_RS01925	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GN308_RS01940	COG0745	RESPONSE REGULATOR receiver
GN308_RS01940	COG3292	Two component regulator propeller
GN308_RS01940	COG2205	protein histidine kinase activity
GN308_RS01995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GN308_RS02000	COG1854	S-ribosylhomocysteine lyase activity
GN308_RS02005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GN308_RS02020	COG0438	transferase activity, transferring glycosyl groups
GN308_RS02035	COG3475	LICD family
GN308_RS02060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN308_RS02060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN308_RS02305	COG4974	Belongs to the 'phage' integrase family
GN308_RS02310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GN308_RS02325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GN308_RS02340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GN308_RS02360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GN308_RS02370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GN308_RS02370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GN308_RS02375	COG2890	protein-(glutamine-N5) methyltransferase activity
GN308_RS02385	COG1040	competence protein
GN308_RS02390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GN308_RS02400	COG0165	Argininosuccinate lyase
GN308_RS02405	COG0667	Aldo Keto reductase
GN308_RS02525	COG3189	MarR family transcriptional regulator
GN308_RS02530	COG0439	Biotin carboxylase
GN308_RS02540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN308_RS02555	COG2096	Adenosyltransferase
GN308_RS02570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GN308_RS02575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GN308_RS02580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GN308_RS02590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GN308_RS02595	COG1519	Transferase
GN308_RS02640	COG1022	Amp-dependent synthetase and ligase
GN308_RS02650	COG2954	triphosphatase activity
GN308_RS02670	COG0733	neurotransmitter:sodium symporter activity
GN308_RS02680	COG1785	Belongs to the alkaline phosphatase family
GN308_RS02720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GN308_RS02760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GN308_RS02765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS02775	COG1192	Involved in chromosome partitioning
GN308_RS02790	COG3385	transposase activity
GN308_RS02940	COG3385	transposase activity
GN308_RS02975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GN308_RS02980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GN308_RS02985	COG1663	tetraacyldisaccharide 4'-kinase activity
GN308_RS02990	COG0616	signal peptide processing
GN308_RS03040	COG0811	peptide transport
GN308_RS03070	COG1131	(ABC) transporter
GN308_RS03090	COG0534	Mate efflux family protein
GN308_RS03100	COG1187	pseudouridine synthase activity
GN308_RS03105	COG0017	Asparaginyl-tRNA synthetase
GN308_RS03125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GN308_RS03130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GN308_RS03135	COG0052	Belongs to the universal ribosomal protein uS2 family
GN308_RS03140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GN308_RS03150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GN308_RS03155	COG0179	Fumarylacetoacetate (FAA) hydrolase
GN308_RS03160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GN308_RS03165	COG1575	Belongs to the MenA family. Type 1 subfamily
GN308_RS03170	COG1408	metallophosphoesterase
GN308_RS03180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GN308_RS03190	COG0194	GDP metabolic process
GN308_RS03200	COG1214	PFAM Peptidase M22, glycoprotease
GN308_RS03210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GN308_RS03215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GN308_RS03220	COG0739	heme binding
GN308_RS03225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GN308_RS03230	COG0750	zinc metalloprotease
GN308_RS03245	COG1272	protein, Hemolysin III
GN308_RS03250	COG0617	tRNA 3'-terminal CCA addition
GN308_RS03260	COG0632	four-way junction helicase activity
GN308_RS03265	COG0673	inositol 2-dehydrogenase activity
GN308_RS03270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GN308_RS03285	COG1621	beta-fructofuranosidase activity
GN308_RS03295	COG1105	Belongs to the carbohydrate kinase PfkB family
GN308_RS03300	COG2205	protein histidine kinase activity
GN308_RS03300	COG3292	Two component regulator propeller
GN308_RS03300	COG0745	RESPONSE REGULATOR receiver
GN308_RS03310	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GN308_RS03320	COG0254	rRNA binding
GN308_RS03325	COG0191	fructose-bisphosphate aldolase activity
GN308_RS03370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GN308_RS03370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GN308_RS03380	COG0563	adenylate kinase activity
GN308_RS03385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GN308_RS03425	COG0138	bifunctional purine biosynthesis protein purh
GN308_RS03470	COG1482	cell wall glycoprotein biosynthetic process
GN308_RS03475	COG2706	6-phosphogluconolactonase activity
GN308_RS03490	COG0523	cobalamin synthesis protein
GN308_RS03505	COG4771	TonB-dependent receptor
GN308_RS03510	COG3292	Two component regulator propeller
GN308_RS03510	COG2205	protein histidine kinase activity
GN308_RS03510	COG0745	RESPONSE REGULATOR receiver
GN308_RS03530	COG4999	Histidine kinase
GN308_RS03530	COG3850	Histidine kinase
GN308_RS03530	COG3437	response regulator, receiver
GN308_RS03530	COG2205	protein histidine kinase activity
GN308_RS03535	COG5002	protein histidine kinase activity
GN308_RS03540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS03545	COG1007	ATP synthesis coupled electron transport
GN308_RS03550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN308_RS03555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GN308_RS03565	COG0839	Belongs to the complex I subunit 6 family
GN308_RS03570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN308_RS03575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GN308_RS03580	COG0649	NAD binding
GN308_RS03585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN308_RS03590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GN308_RS03595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GN308_RS03600	COG0569	domain protein
GN308_RS03605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GN308_RS03615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GN308_RS03630	COG3250	beta-galactosidase activity
GN308_RS03645	COG3119	arylsulfatase activity
GN308_RS03650	COG0702	epimerase
GN308_RS03655	COG1629	transport
GN308_RS03655	COG4206	TonB-dependent receptor
GN308_RS03690	COG4206	TonB-dependent receptor
GN308_RS03690	COG1629	transport
GN308_RS03730	COG4771	TonB-dependent receptor
GN308_RS03740	COG3250	beta-galactosidase activity
GN308_RS03755	COG0745	RESPONSE REGULATOR receiver
GN308_RS03755	COG2205	protein histidine kinase activity
GN308_RS03755	COG3292	Two component regulator propeller
GN308_RS03765	COG3250	beta-galactosidase activity
GN308_RS03770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS03780	COG3940	Belongs to the glycosyl hydrolase 43 family
GN308_RS03780	COG3940	Belongs to the glycosyl hydrolase 43 family
GN308_RS03795	COG1629	transport
GN308_RS03805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS03820	COG0745	RESPONSE REGULATOR receiver
GN308_RS03820	COG2205	protein histidine kinase activity
GN308_RS03820	COG3292	Two component regulator propeller
GN308_RS03825	COG1012	belongs to the aldehyde dehydrogenase family
GN308_RS03850	COG2271	Major facilitator Superfamily
GN308_RS03855	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GN308_RS03860	COG3775	system Galactitol-specific IIC component
GN308_RS03865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS03870	COG4677	pectinesterase activity
GN308_RS03875	COG1629	transport
GN308_RS03885	COG0515	serine threonine protein kinase
GN308_RS03885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GN308_RS03890	COG4771	TonB-dependent receptor
GN308_RS03895	COG0702	epimerase
GN308_RS03900	COG3507	Belongs to the glycosyl hydrolase 43 family
GN308_RS03930	COG4771	TonB-dependent receptor
GN308_RS03960	COG1917	Cupin 2, conserved barrel domain protein
GN308_RS03975	COG2755	lipolytic protein G-D-S-L family
GN308_RS03980	COG0745	RESPONSE REGULATOR receiver
GN308_RS03980	COG2205	protein histidine kinase activity
GN308_RS03980	COG3292	Two component regulator propeller
GN308_RS03990	COG1506	peptidase
GN308_RS03990	COG0823	Involved in the tonB-independent uptake of proteins
GN308_RS04005	COG0138	bifunctional purine biosynthesis protein purh
GN308_RS04025	COG0768	penicillin binding
GN308_RS04030	COG0772	Belongs to the SEDS family
GN308_RS04040	COG1774	PSP1 C-terminal conserved region
GN308_RS04045	COG0470	DNA polymerase III
GN308_RS04050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GN308_RS04070	COG0628	permease
GN308_RS04075	COG1435	thymidine kinase activity
GN308_RS04080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GN308_RS04100	COG1629	transport
GN308_RS04110	COG4206	TonB-dependent receptor
GN308_RS04110	COG1629	transport
GN308_RS04125	COG4206	TonB-dependent receptor
GN308_RS04125	COG1629	transport
GN308_RS04130	COG4974	Belongs to the 'phage' integrase family
GN308_RS04135	COG4771	TonB-dependent receptor
GN308_RS04145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GN308_RS04160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GN308_RS04160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GN308_RS04170	COG0531	amino acid
GN308_RS04180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GN308_RS04185	COG1566	PFAM secretion protein HlyD family protein
GN308_RS04195	COG1162	GTPase activity
GN308_RS04200	COG0233	cytoplasmic translational termination
GN308_RS04220	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS04225	COG0528	UMP kinase activity
GN308_RS04230	COG0534	Mate efflux family protein
GN308_RS04240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GN308_RS04240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GN308_RS04250	COG0792	nuclease activity
GN308_RS04270	COG1183	phosphatidylcholine synthase activity
GN308_RS04275	COG0688	phosphatidylethanolamine metabolic process
GN308_RS04305	COG0802	atpase or kinase
GN308_RS04310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GN308_RS04325	COG1830	Aldolase
GN308_RS04330	COG0588	phosphoglycerate mutase activity
GN308_RS04345	COG0475	glutathione-regulated potassium exporter activity
GN308_RS04465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GN308_RS04480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GN308_RS04485	COG0742	ribosomal rna small subunit methyltransferase
GN308_RS04505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GN308_RS04510	COG0739	heme binding
GN308_RS04520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GN308_RS04525	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN308_RS04525	COG1388	LysM domain
GN308_RS04535	COG1475	DNA binding
GN308_RS04540	COG1192	Involved in chromosome partitioning
GN308_RS04545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GN308_RS04550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN308_RS04565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GN308_RS04580	COG1196	nuclear chromosome segregation
GN308_RS04585	COG2239	Acts as a magnesium transporter
GN308_RS04590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GN308_RS04600	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN308_RS04605	COG0590	tRNA wobble adenosine to inosine editing
GN308_RS04610	COG1396	sequence-specific DNA binding
GN308_RS04620	COG3550	peptidyl-serine autophosphorylation
GN308_RS04625	COG2373	Large extracellular alpha-helical protein
GN308_RS04645	COG0205	6-phosphofructokinase activity
GN308_RS04650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GN308_RS04655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GN308_RS04670	COG0084	hydrolase, TatD family'
GN308_RS04680	COG0811	peptide transport
GN308_RS04710	COG1522	sequence-specific DNA binding
GN308_RS04720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GN308_RS04730	COG1595	DNA-templated transcription, initiation
GN308_RS04740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GN308_RS04740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GN308_RS04765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GN308_RS04770	COG0538	isocitrate dehydrogenase activity
GN308_RS04775	COG0372	Belongs to the citrate synthase family
GN308_RS04790	COG1902	pentaerythritol trinitrate reductase activity
GN308_RS04820	COG0205	6-phosphofructokinase activity
GN308_RS04825	COG0546	phosphoglycolate phosphatase activity
GN308_RS04840	COG0511	ligase activity, forming carbon-carbon bonds
GN308_RS04845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GN308_RS04850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS04860	COG0561	phosphatase activity
GN308_RS04865	COG4771	TonB-dependent receptor
GN308_RS04895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GN308_RS04915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GN308_RS04920	COG1506	peptidase
GN308_RS04920	COG0823	Involved in the tonB-independent uptake of proteins
GN308_RS04925	COG1242	4 iron, 4 sulfur cluster binding
GN308_RS04930	COG0426	domain, Protein
GN308_RS04935	COG0668	transmembrane transport
GN308_RS04940	COG0009	L-threonylcarbamoyladenylate synthase
GN308_RS04945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GN308_RS05005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN308_RS05010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GN308_RS05015	COG0066	3-isopropylmalate dehydratase activity
GN308_RS05020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN308_RS05025	COG0473	3-isopropylmalate dehydrogenase activity
GN308_RS05035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GN308_RS05045	COG0514	ATP-dependent DNA helicase (RecQ)
GN308_RS05065	COG0735	belongs to the Fur family
GN308_RS05070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GN308_RS05080	COG1629	transport
GN308_RS05080	COG4206	TonB-dependent receptor
GN308_RS05095	COG2755	lipolytic protein G-D-S-L family
GN308_RS05110	COG4771	TonB-dependent receptor
GN308_RS05125	COG0488	(ABC) transporter
GN308_RS05130	COG3590	peptidase
GN308_RS05140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS05155	COG0673	inositol 2-dehydrogenase activity
GN308_RS05160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GN308_RS05165	COG0826	peptidase U32
GN308_RS05175	COG4771	TonB-dependent receptor
GN308_RS05190	COG0095	Lipoate-protein ligase
GN308_RS05195	COG0508	dehydrogenase complex catalyzes the overall conversion of
GN308_RS05200	COG0022	dehydrogenase e1 component
GN308_RS05205	COG0716	FMN binding
GN308_RS05210	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GN308_RS05220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GN308_RS05235	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GN308_RS05240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GN308_RS05245	COG1120	ATPase activity
GN308_RS05250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GN308_RS05275	COG1073	alpha beta
GN308_RS05295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GN308_RS05300	COG0436	Aminotransferase
GN308_RS05310	COG1733	regulation of RNA biosynthetic process
GN308_RS05320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GN308_RS05325	COG0628	permease
GN308_RS05335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS05340	COG0514	ATP-dependent DNA helicase (RecQ)
GN308_RS05345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GN308_RS05345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GN308_RS05355	COG0006	proline dipeptidase activity
GN308_RS05370	COG1418	mRNA catabolic process
GN308_RS05385	COG2832	Protein of unknown function (DUF454)
GN308_RS05395	COG0602	queuosine metabolic process
GN308_RS05415	COG1115	amino acid carrier protein
GN308_RS05425	COG2205	protein histidine kinase activity
GN308_RS05425	COG3292	Two component regulator propeller
GN308_RS05425	COG0745	RESPONSE REGULATOR receiver
GN308_RS05435	COG3681	Belongs to the UPF0597 family
GN308_RS05490	COG4804	nuclease activity
GN308_RS05500	COG4974	Belongs to the 'phage' integrase family
GN308_RS05680	COG3275	phosphorelay sensor kinase activity
GN308_RS05730	COG4771	TonB-dependent receptor
GN308_RS05735	COG0702	epimerase
GN308_RS05740	COG3250	beta-galactosidase activity
GN308_RS05745	COG3292	Two component regulator propeller
GN308_RS05745	COG0745	RESPONSE REGULATOR receiver
GN308_RS05745	COG2205	protein histidine kinase activity
GN308_RS05770	COG4771	TonB-dependent receptor
GN308_RS05855	COG1629	transport
GN308_RS05855	COG4206	TonB-dependent receptor
GN308_RS05865	COG0126	phosphoglycerate kinase activity
GN308_RS05875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS05895	COG0534	Mate efflux family protein
GN308_RS05900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GN308_RS05905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GN308_RS05930	COG1629	transport
GN308_RS05940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS05945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS05960	COG2205	protein histidine kinase activity
GN308_RS05960	COG3292	Two component regulator propeller
GN308_RS05960	COG0745	RESPONSE REGULATOR receiver
GN308_RS05965	COG4771	TonB-dependent receptor
GN308_RS06035	COG4372	Transposase
GN308_RS06055	COG1091	dTDP-4-dehydrorhamnose reductase activity
GN308_RS06065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GN308_RS06100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GN308_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS06150	COG2244	polysaccharide biosynthetic process
GN308_RS06160	COG0513	Belongs to the DEAD box helicase family
GN308_RS06265	COG4974	Belongs to the 'phage' integrase family
GN308_RS06290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GN308_RS06305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GN308_RS06305	COG0321	lipoyl(octanoyl) transferase activity
GN308_RS06310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GN308_RS06315	COG1834	amidinotransferase
GN308_RS06325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GN308_RS06335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GN308_RS06350	COG4413	Urea transporter
GN308_RS06355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GN308_RS06370	COG3591	Belongs to the peptidase S1B family
GN308_RS06375	COG3591	Belongs to the peptidase S1B family
GN308_RS06390	COG1408	metallophosphoesterase
GN308_RS06395	COG0646	methionine synthase
GN308_RS06395	COG1410	methionine synthase
GN308_RS06400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GN308_RS06405	COG0463	Glycosyl transferase, family 2
GN308_RS06450	COG2311	Membrane
GN308_RS06455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GN308_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GN308_RS06485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GN308_RS06495	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GN308_RS06515	COG1032	radical SAM domain protein
GN308_RS06530	COG5434	Belongs to the glycosyl hydrolase 28 family
GN308_RS06560	COG2264	protein methyltransferase activity
GN308_RS06600	COG0673	inositol 2-dehydrogenase activity
GN308_RS06605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GN308_RS06655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GN308_RS06665	COG2160	L-arabinose isomerase activity
GN308_RS06690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GN308_RS06710	COG0484	heat shock protein binding
GN308_RS06715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GN308_RS06720	COG0488	(ABC) transporter
GN308_RS06740	COG0393	Putative heavy-metal-binding
GN308_RS06775	COG1388	LysM domain
GN308_RS06775	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN308_RS06785	COG1136	(ABC) transporter
GN308_RS06790	COG0577	efflux transmembrane transporter activity
GN308_RS06800	COG1136	(ABC) transporter
GN308_RS06800	COG0577	efflux transmembrane transporter activity
GN308_RS06810	COG0577	efflux transmembrane transporter activity
GN308_RS06810	COG1136	(ABC) transporter
GN308_RS06835	COG2204	response regulator
GN308_RS06840	COG4191	Histidine kinase
GN308_RS06875	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GN308_RS06880	COG0572	uridine kinase
GN308_RS06895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GN308_RS06900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GN308_RS06905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GN308_RS06910	COG0131	Imidazoleglycerol-phosphate dehydratase
GN308_RS06925	COG1592	Rubrerythrin
GN308_RS06925	COG1773	rubredoxin
GN308_RS06935	COG3118	belongs to the thioredoxin family
GN308_RS06950	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN308_RS06960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GN308_RS06965	COG0157	Belongs to the NadC ModD family
GN308_RS06970	COG2205	protein histidine kinase activity
GN308_RS06970	COG0745	RESPONSE REGULATOR receiver
GN308_RS06970	COG3292	Two component regulator propeller
GN308_RS06980	COG4771	TonB-dependent receptor
GN308_RS06995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GN308_RS07000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GN308_RS07020	COG0443	Heat shock 70 kDa protein
GN308_RS07105	COG1216	Glycosyl transferase, family 2
GN308_RS07110	COG0438	transferase activity, transferring glycosyl groups
GN308_RS07125	COG0438	transferase activity, transferring glycosyl groups
GN308_RS07145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GN308_RS07205	COG0556	nucleotide-excision repair
GN308_RS07225	COG4948	Mandelate Racemase Muconate Lactonizing
GN308_RS07235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GN308_RS07240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GN308_RS07245	COG1169	isochorismate synthase
GN308_RS07250	COG2050	protein possibly involved in aromatic compounds catabolism
GN308_RS07255	COG0490	domain, Protein
GN308_RS07255	COG0471	metal ion transport
GN308_RS07260	COG0534	Mate efflux family protein
GN308_RS07265	COG0446	pyridine nucleotide-disulphide oxidoreductase
GN308_RS07280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GN308_RS07290	COG4771	TonB-dependent receptor
GN308_RS07300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS07315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GN308_RS07320	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GN308_RS07325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GN308_RS07330	COG0569	domain protein
GN308_RS07345	COG1760	l-serine dehydratase
GN308_RS07365	COG4771	TonB-dependent receptor
GN308_RS07390	COG2226	methyltransferase
GN308_RS07400	COG0582	viral genome integration into host DNA
GN308_RS07405	COG1193	negative regulation of DNA recombination
GN308_RS07430	COG2755	lipolytic protein G-D-S-L family
GN308_RS07430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GN308_RS07440	COG2217	Heavy metal translocating P-type atpase
GN308_RS07450	COG4221	oxidoreductase activity
GN308_RS07460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GN308_RS07465	COG0511	ligase activity, forming carbon-carbon bonds
GN308_RS07475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN308_RS07490	COG0778	Nitroreductase
GN308_RS07505	COG0561	phosphatase activity
GN308_RS07510	COG0424	maF-like protein
GN308_RS07515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GN308_RS07530	COG2814	Major facilitator Superfamily
GN308_RS07535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS07540	COG1309	transcriptional regulator
GN308_RS07550	COG0596	Alpha beta hydrolase
GN308_RS07550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GN308_RS07550	COG2226	methyltransferase
GN308_RS07555	COG1132	(ABC) transporter
GN308_RS07620	COG0768	penicillin binding
GN308_RS07710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GN308_RS07715	COG1410	methionine synthase
GN308_RS07715	COG0646	methionine synthase
GN308_RS07720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN308_RS07730	COG2233	PERMEase
GN308_RS07735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GN308_RS07750	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GN308_RS07750	COG0778	Nitroreductase
GN308_RS07760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GN308_RS07765	COG1704	LemA family
GN308_RS07780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GN308_RS07785	COG2226	methyltransferase
GN308_RS07790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GN308_RS07795	COG1702	phosphate starvation-inducible protein PhoH
GN308_RS07805	COG0101	tRNA pseudouridine synthase activity
GN308_RS07820	COG1047	Peptidyl-prolyl cis-trans
GN308_RS07830	COG0129	dihydroxy-acid dehydratase activity
GN308_RS07850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GN308_RS07875	COG1253	flavin adenine dinucleotide binding
GN308_RS07895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GN308_RS07910	COG0653	protein targeting
GN308_RS07940	COG0525	valine-tRNA ligase activity
GN308_RS07945	COG3956	TIGRFAM MazG family protein
GN308_RS07955	COG4771	TonB-dependent receptor
GN308_RS07970	COG1595	DNA-templated transcription, initiation
GN308_RS07975	COG1234	tRNA 3'-trailer cleavage
GN308_RS07985	COG0539	negative regulation of cytoplasmic translation
GN308_RS07995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GN308_RS08015	COG3275	phosphorelay sensor kinase activity
GN308_RS08050	COG1215	transferase activity, transferring glycosyl groups
GN308_RS08055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GN308_RS08065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GN308_RS08070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN308_RS08095	COG0738	Major facilitator superfamily
GN308_RS08100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GN308_RS08110	COG2204	response regulator
GN308_RS08130	COG0708	Exodeoxyribonuclease III
GN308_RS08145	COG1741	Belongs to the pirin family
GN308_RS08160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GN308_RS08170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GN308_RS08185	COG0793	Belongs to the peptidase S41A family
GN308_RS08190	COG2131	deaminase
GN308_RS08200	COG0339	signal peptide processing
GN308_RS08215	COG1477	protein flavinylation
GN308_RS08220	COG1971	Probably functions as a manganese efflux pump
GN308_RS08235	COG0463	Glycosyl transferase, family 2
GN308_RS08250	COG0514	ATP-dependent DNA helicase (RecQ)
GN308_RS08260	COG0148	phosphopyruvate hydratase activity
GN308_RS08270	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS08280	COG3408	Glycogen debranching enzyme
GN308_RS08305	COG0662	Cupin 2, conserved barrel domain protein
GN308_RS08305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GN308_RS08310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS08315	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GN308_RS08335	COG1216	Glycosyl transferase, family 2
GN308_RS08340	COG0110	maltose O-acetyltransferase activity
GN308_RS08365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GN308_RS08375	COG3754	Rhamnan synthesis protein F
GN308_RS08405	COG1091	dTDP-4-dehydrorhamnose reductase activity
GN308_RS08450	COG3023	N-Acetylmuramoyl-L-alanine amidase
GN308_RS08470	COG4974	Belongs to the 'phage' integrase family
GN308_RS08660	COG4974	Belongs to the 'phage' integrase family
GN308_RS08675	COG1132	(ABC) transporter
GN308_RS08695	COG2226	methyltransferase
GN308_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS08730	COG3321	synthase
GN308_RS08730	COG0318	PFAM AMP-dependent synthetase and ligase
GN308_RS08730	COG0300	oxidoreductase activity
GN308_RS08730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GN308_RS08785	COG4974	Belongs to the 'phage' integrase family
GN308_RS08790	COG4974	Belongs to the 'phage' integrase family
GN308_RS08825	COG4974	Belongs to the 'phage' integrase family
GN308_RS08830	COG0732	type I restriction modification DNA specificity domain
GN308_RS08845	COG0732	type I restriction modification DNA specificity domain
GN308_RS08875	COG4974	Belongs to the 'phage' integrase family
GN308_RS08880	COG4974	Belongs to the 'phage' integrase family
GN308_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS08970	COG0525	valine-tRNA ligase activity
GN308_RS08990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GN308_RS09000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GN308_RS09055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GN308_RS09065	COG1309	transcriptional regulator
GN308_RS09075	COG0739	heme binding
GN308_RS09150	COG1705	Flagellar rod assembly protein muramidase FlgJ
GN308_RS09240	COG1475	DNA binding
GN308_RS09270	COG0582	viral genome integration into host DNA
GN308_RS09375	COG3250	beta-galactosidase activity
GN308_RS09390	COG2985	domain, Protein
GN308_RS09390	COG0490	domain, Protein
GN308_RS09395	COG4206	TonB-dependent receptor
GN308_RS09395	COG1629	transport
GN308_RS09405	COG4771	TonB-dependent receptor
GN308_RS09415	COG3250	beta-galactosidase activity
GN308_RS09420	COG3250	beta-galactosidase activity
GN308_RS09425	COG3940	Belongs to the glycosyl hydrolase 43 family
GN308_RS09450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN308_RS09455	COG0110	maltose O-acetyltransferase activity
GN308_RS09480	COG1216	Glycosyl transferase, family 2
GN308_RS09485	COG0438	transferase activity, transferring glycosyl groups
GN308_RS09490	COG1216	Glycosyl transferase, family 2
GN308_RS09495	COG0463	Glycosyl transferase, family 2
GN308_RS09500	COG0438	transferase activity, transferring glycosyl groups
GN308_RS09540	COG1442	glycosyl transferase family 8
GN308_RS09545	COG1231	oxidoreductase activity
GN308_RS09555	COG1216	Glycosyl transferase, family 2
GN308_RS09560	COG1216	Glycosyl transferase, family 2
GN308_RS09565	COG1215	transferase activity, transferring glycosyl groups
GN308_RS09595	COG0489	protein tyrosine kinase activity
GN308_RS09595	COG3206	protein involved in exopolysaccharide biosynthesis
GN308_RS09605	COG1132	(ABC) transporter
GN308_RS09655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GN308_RS09685	COG0598	Magnesium transport protein CorA
GN308_RS09690	COG1522	sequence-specific DNA binding
GN308_RS09700	COG0586	Pfam SNARE associated Golgi protein
GN308_RS09710	COG0306	phosphate transporter
GN308_RS09720	COG4771	TonB-dependent receptor
GN308_RS09730	COG2873	o-acetylhomoserine
GN308_RS09735	COG1620	l-lactate permease
GN308_RS09755	COG2205	protein histidine kinase activity
GN308_RS09780	COG0668	transmembrane transport
GN308_RS09785	COG0318	PFAM AMP-dependent synthetase and ligase
GN308_RS09795	COG0307	riboflavin synthase, alpha
GN308_RS09800	COG1295	ribonuclease BN
GN308_RS09820	COG0484	heat shock protein binding
GN308_RS09830	COG0737	Belongs to the 5'-nucleotidase family
GN308_RS09840	COG4771	TonB-dependent receptor
GN308_RS09845	COG1509	lysine 2,3-aminomutase activity
GN308_RS09855	COG3408	Glycogen debranching enzyme
GN308_RS09870	COG2205	protein histidine kinase activity
GN308_RS09870	COG0784	Response regulator, receiver
GN308_RS09880	COG3059	membrane
GN308_RS09885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GN308_RS09890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GN308_RS09910	COG1914	H( )-stimulated, divalent metal cation uptake system
GN308_RS09915	COG3263	regulation of cellular component size
GN308_RS09920	COG0534	Mate efflux family protein
GN308_RS09930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GN308_RS09940	COG0488	(ABC) transporter
GN308_RS10010	COG0228	four-way junction DNA binding
GN308_RS10020	COG0657	acetylesterase activity
GN308_RS10020	COG2755	lipolytic protein G-D-S-L family
GN308_RS10045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GN308_RS10050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GN308_RS10085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GN308_RS10090	COG1333	cytochrome c biogenesis protein
GN308_RS10090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GN308_RS10110	COG1730	sister chromatid segregation
GN308_RS10125	COG0438	transferase activity, transferring glycosyl groups
GN308_RS10140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GN308_RS10140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN308_RS10145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GN308_RS10145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN308_RS10160	COG2226	methyltransferase
GN308_RS10175	COG0004	ammonium transporteR
GN308_RS10180	COG0347	Belongs to the P(II) protein family
GN308_RS10190	COG0436	Aminotransferase
GN308_RS10195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GN308_RS10200	COG1119	ATPase activity
GN308_RS10205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GN308_RS10210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GN308_RS10220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GN308_RS10225	COG0252	asparaginase activity
GN308_RS10250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GN308_RS10255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GN308_RS10260	COG0363	glucosamine-6-phosphate deaminase activity
GN308_RS10270	COG1271	oxidase subunit
GN308_RS10285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS10290	COG1136	(ABC) transporter
GN308_RS10295	COG0577	efflux transmembrane transporter activity
GN308_RS10295	COG1136	(ABC) transporter
GN308_RS10305	COG3279	Response regulator of the LytR AlgR family
GN308_RS10320	COG4566	intracellular signal transduction
GN308_RS10325	COG0247	lactate metabolic process
GN308_RS10330	COG1139	Iron-sulfur cluster binding protein
GN308_RS10345	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GN308_RS10370	COG0259	pyridoxamine-phosphate oxidase activity
GN308_RS10380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GN308_RS10380	COG1918	ferrous iron import across plasma membrane
GN308_RS10395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GN308_RS10400	COG0497	DNA recombination
GN308_RS10430	COG0297	glycogen (starch) synthase activity
GN308_RS10435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GN308_RS10440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GN308_RS10445	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GN308_RS10455	COG2816	NAD+ diphosphatase activity
GN308_RS10460	COG2183	response to ionizing radiation
GN308_RS10470	COG0745	RESPONSE REGULATOR receiver
GN308_RS10470	COG3292	Two component regulator propeller
GN308_RS10470	COG2205	protein histidine kinase activity
GN308_RS10480	COG4206	TonB-dependent receptor
GN308_RS10480	COG1629	transport
GN308_RS10520	COG4771	TonB-dependent receptor
GN308_RS10535	COG1629	transport
GN308_RS10650	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
GN308_RS10795	COG0776	regulation of translation
GN308_RS10815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GN308_RS10875	COG1501	Belongs to the glycosyl hydrolase 31 family
GN308_RS10890	COG0251	oxidation-reduction process
GN308_RS10915	COG0488	(ABC) transporter
GN308_RS10940	COG1216	Glycosyl transferase, family 2
GN308_RS10955	COG1215	transferase activity, transferring glycosyl groups
GN308_RS10965	COG0562	UDP-galactopyranose mutase
GN308_RS10975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS11025	COG2207	Transcriptional regulator
GN308_RS11030	COG2706	6-phosphogluconolactonase activity
GN308_RS11040	COG4771	TonB-dependent receptor
GN308_RS11045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS11065	COG0667	Aldo Keto reductase
GN308_RS11075	COG0655	NAD(P)H dehydrogenase (quinone) activity
GN308_RS11095	COG2095	MarC family integral membrane protein
GN308_RS11105	COG1830	Aldolase
GN308_RS11110	COG0588	phosphoglycerate mutase activity
GN308_RS11125	COG0205	6-phosphofructokinase activity
GN308_RS11130	COG4651	solute:proton antiporter activity
GN308_RS11130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GN308_RS11135	COG0058	SHG alpha-glucan phosphorylase activity
GN308_RS11140	COG0010	Belongs to the arginase family
GN308_RS11180	COG1136	(ABC) transporter
GN308_RS11180	COG0577	efflux transmembrane transporter activity
GN308_RS11185	COG0577	efflux transmembrane transporter activity
GN308_RS11205	COG0217	transcriptional regulatory protein
GN308_RS11210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GN308_RS11210	COG0072	phenylalanine-tRNA ligase activity
GN308_RS11215	COG0305	Participates in initiation and elongation during chromosome replication
GN308_RS11220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GN308_RS11235	COG4191	Histidine kinase
GN308_RS11245	COG0386	Belongs to the glutathione peroxidase family
GN308_RS11275	COG1216	Glycosyl transferase, family 2
GN308_RS11290	COG0438	transferase activity, transferring glycosyl groups
GN308_RS11300	COG1442	glycosyl transferase family 8
GN308_RS11300	COG1216	Glycosyl transferase, family 2
GN308_RS11330	COG0339	signal peptide processing
GN308_RS11340	COG0577	efflux transmembrane transporter activity
GN308_RS11340	COG1136	(ABC) transporter
GN308_RS11355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GN308_RS11360	COG0574	Belongs to the PEP-utilizing enzyme family
GN308_RS11360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GN308_RS11365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GN308_RS11370	COG0564	pseudouridine synthase activity
GN308_RS11375	COG1506	peptidase
GN308_RS11375	COG0823	Involved in the tonB-independent uptake of proteins
GN308_RS11380	COG0706	membrane insertase activity
GN308_RS11385	COG0504	CTP synthase activity
GN308_RS11420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GN308_RS11425	COG2885	chlorophyll binding
GN308_RS11430	COG0534	Mate efflux family protein
GN308_RS11435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GN308_RS11450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GN308_RS11455	COG0540	Belongs to the ATCase OTCase family
GN308_RS11470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GN308_RS11475	COG0842	Transport permease protein
GN308_RS11475	COG1129	ABC transporter
GN308_RS11480	COG0842	Transport permease protein
GN308_RS11485	COG1131	(ABC) transporter
GN308_RS11490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS11510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GN308_RS11540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GN308_RS11550	COG0442	prolyl-tRNA aminoacylation
GN308_RS11555	COG1131	(ABC) transporter
GN308_RS11560	COG0390	transport system, permease component
GN308_RS11570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GN308_RS11585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GN308_RS11600	COG0543	2 iron, 2 sulfur cluster binding
GN308_RS11605	COG0167	dihydroorotate dehydrogenase activity
GN308_RS11610	COG0336	Belongs to the RNA methyltransferase TrmD family
GN308_RS11615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GN308_RS11620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GN308_RS11640	COG1752	Esterase of the alpha-beta hydrolase superfamily
GN308_RS11650	COG0542	response to heat
GN308_RS11675	COG0671	phosphoesterase, PA-phosphatase related
GN308_RS11700	COG2304	oxidoreductase activity
GN308_RS11715	COG0714	Associated with various cellular activities
GN308_RS11720	COG0776	regulation of translation
GN308_RS11725	COG0776	regulation of translation
GN308_RS11730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN308_RS11735	COG0552	protein localization to endoplasmic reticulum
GN308_RS11745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GN308_RS11750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GN308_RS11760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GN308_RS11765	COG0024	Methionine aminopeptidase
GN308_RS11775	COG0110	maltose O-acetyltransferase activity
GN308_RS11780	COG0697	spore germination
GN308_RS11790	COG4176	ABC-type proline glycine betaine transport system permease component
GN308_RS11800	COG2204	response regulator
GN308_RS11805	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GN308_RS11815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GN308_RS11820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GN308_RS11825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GN308_RS11855	COG3387	PFAM Glycoside hydrolase 15-related
GN308_RS11875	COG4106	trans-aconitate 2-methyltransferase activity
GN308_RS11880	COG1733	regulation of RNA biosynthetic process
GN308_RS11890	COG0494	nUDIX hydrolase
GN308_RS11900	COG2205	protein histidine kinase activity
GN308_RS11910	COG1285	pathogenesis
GN308_RS11920	COG0561	phosphatase activity
GN308_RS11935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GN308_RS11955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GN308_RS11960	COG0513	Belongs to the DEAD box helicase family
GN308_RS11970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN308_RS11975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN308_RS11980	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GN308_RS11985	COG1805	sodium ion transport
GN308_RS12010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GN308_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS12055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GN308_RS12075	COG2244	polysaccharide biosynthetic process
GN308_RS12085	COG3579	cysteine-type endopeptidase activity
GN308_RS12120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GN308_RS12125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GN308_RS12195	COG4771	TonB-dependent receptor
GN308_RS12205	COG3852	Histidine kinase
GN308_RS12250	COG1136	(ABC) transporter
GN308_RS12265	COG0156	8-amino-7-oxononanoate synthase activity
GN308_RS12270	COG1597	lipid kinase activity
GN308_RS12275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GN308_RS12280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GN308_RS12285	COG0343	queuine tRNA-ribosyltransferase activity
GN308_RS12295	COG1011	Hydrolase
GN308_RS12305	COG0560	Phosphoserine phosphatase
GN308_RS12305	COG3830	Belongs to the UPF0237 family
GN308_RS12310	COG0513	Belongs to the DEAD box helicase family
GN308_RS12345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GN308_RS12370	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GN308_RS12380	COG1492	cobalamin metabolic process
GN308_RS12385	COG2096	Adenosyltransferase
GN308_RS12390	COG1797	cobyrinic acid a,c-diamide synthase activity
GN308_RS12400	COG4771	TonB-dependent receptor
GN308_RS12405	COG4771	TonB-dependent receptor
GN308_RS12430	COG0439	Biotin carboxylase
GN308_RS12440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GN308_RS12460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GN308_RS12465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GN308_RS12470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GN308_RS12475	COG4771	TonB-dependent receptor
GN308_RS12485	COG4771	TonB-dependent receptor
GN308_RS12495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GN308_RS12500	COG2207	Transcriptional regulator
GN308_RS12500	COG4753	response regulator
GN308_RS12505	COG0662	Cupin 2, conserved barrel domain protein
GN308_RS12505	COG2207	Transcriptional regulator
GN308_RS12535	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GN308_RS12540	COG1120	ATPase activity
GN308_RS12545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GN308_RS12565	COG0246	Mannitol dehydrogenase
GN308_RS12570	COG1904	glucuronate isomerase
GN308_RS12585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GN308_RS12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GN308_RS12640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GN308_RS12650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GN308_RS12660	COG0501	Belongs to the peptidase M48B family
GN308_RS12675	COG1609	Transcriptional regulator
GN308_RS12680	COG2721	sulfolactate sulfo-lyase activity
GN308_RS12685	COG1757	Na H antiporter
GN308_RS12700	COG2431	L-lysine efflux transmembrane transporter activity
GN308_RS12705	COG3104	oligopeptide transport
GN308_RS12710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GN308_RS12720	COG3942	CHAP domain
GN308_RS12720	COG1388	LysM domain
GN308_RS12745	COG0556	nucleotide-excision repair
GN308_RS12755	COG1739	Uncharacterized protein family UPF0029
GN308_RS12760	COG2176	DNA-directed DNA polymerase activity
GN308_RS12765	COG1752	Esterase of the alpha-beta hydrolase superfamily
GN308_RS12770	COG1312	Catalyzes the dehydration of D-mannonate
GN308_RS12775	COG1523	belongs to the glycosyl hydrolase 13 family
GN308_RS12780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GN308_RS12820	COG4974	Belongs to the 'phage' integrase family
GN308_RS12840	COG3617	BRO family, N-terminal domain
GN308_RS12875	COG1252	NADH dehydrogenase
GN308_RS12880	COG1022	Amp-dependent synthetase and ligase
GN308_RS12885	COG0321	lipoyl(octanoyl) transferase activity
GN308_RS12900	COG2217	Heavy metal translocating P-type atpase
GN308_RS12910	COG0357	Ribosomal RNA small subunit methyltransferase G
GN308_RS12915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GN308_RS12920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GN308_RS12920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GN308_RS12935	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GN308_RS12940	COG1979	alcohol dehydrogenase
GN308_RS12960	COG2855	membrane
GN308_RS12965	COG3973	AAA domain
GN308_RS12985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GN308_RS12990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GN308_RS13000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GN308_RS13015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GN308_RS13020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GN308_RS13025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN308_RS13030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GN308_RS13035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN308_RS13040	COG0356	it plays a direct role in the translocation of protons across the membrane
GN308_RS13050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GN308_RS13060	COG0248	Ppx GppA phosphatase
GN308_RS13065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GN308_RS13085	COG5002	protein histidine kinase activity
GN308_RS13090	COG0745	RESPONSE REGULATOR receiver
GN308_RS13100	COG3119	arylsulfatase activity
GN308_RS13110	COG1151	hydroxylamine reductase activity
GN308_RS13115	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GN308_RS13145	COG1678	Uncharacterized ACR, COG1678
GN308_RS13160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GN308_RS13170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GN308_RS13265	COG4206	TonB-dependent receptor
GN308_RS13265	COG1629	transport
GN308_RS13300	COG4974	Belongs to the 'phage' integrase family
GN308_RS13320	COG3852	Histidine kinase
GN308_RS13325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GN308_RS13325	COG3153	acetyltransferase
GN308_RS13385	COG0352	thiamine-phosphate diphosphorylase activity
GN308_RS13390	COG2022	thiamine diphosphate biosynthetic process
GN308_RS13395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GN308_RS13415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GN308_RS13420	COG0754	glutathionylspermidine amidase activity
GN308_RS13430	COG0352	thiamine-phosphate diphosphorylase activity
GN308_RS13435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GN308_RS13445	COG1177	transmembrane transport
GN308_RS13475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS13480	COG0058	SHG alpha-glucan phosphorylase activity
GN308_RS13490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GN308_RS13495	COG1269	ATP hydrolysis coupled proton transport
GN308_RS13510	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GN308_RS13560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS13595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GN308_RS13600	COG1597	lipid kinase activity
GN308_RS13605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GN308_RS13615	COG1970	mechanosensitive ion channel activity
GN308_RS13620	COG0519	Catalyzes the synthesis of GMP from XMP
GN308_RS13620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GN308_RS13625	COG0519	Catalyzes the synthesis of GMP from XMP
GN308_RS13640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS13670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS13685	COG3119	arylsulfatase activity
GN308_RS13720	COG1629	transport
GN308_RS13720	COG4206	TonB-dependent receptor
GN308_RS13740	COG1595	DNA-templated transcription, initiation
GN308_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
GN308_RS13765	COG4133	protoheme IX ABC transporter activity
GN308_RS13785	COG2211	Major facilitator Superfamily
GN308_RS13835	COG1408	metallophosphoesterase
GN308_RS13840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GN308_RS13855	COG1674	ftsk spoiiie
GN308_RS13865	COG0492	ferredoxin-NADP+ reductase activity
GN308_RS13870	COG0612	Peptidase, M16
GN308_RS13880	COG1131	(ABC) transporter
GN308_RS13885	COG0791	NLP P60 protein
GN308_RS13890	COG0546	phosphoglycolate phosphatase activity
GN308_RS13895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GN308_RS13900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GN308_RS13915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GN308_RS13925	COG0543	2 iron, 2 sulfur cluster binding
GN308_RS13945	COG0037	tRNA processing
GN308_RS13960	COG4864	UPF0365 protein
GN308_RS13965	COG0813	purine-nucleoside phosphorylase activity
GN308_RS13975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GN308_RS14035	COG1063	alcohol dehydrogenase
GN308_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS14055	COG0346	lactoylglutathione lyase activity
GN308_RS14070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GN308_RS14095	COG0564	pseudouridine synthase activity
GN308_RS14100	COG0534	Mate efflux family protein
GN308_RS14120	COG1538	Outer membrane efflux protein
GN308_RS14200	COG3279	Response regulator of the LytR AlgR family
GN308_RS14205	COG3275	phosphorelay sensor kinase activity
GN308_RS14220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GN308_RS14230	COG0739	heme binding
GN308_RS14235	COG0686	Belongs to the AlaDH PNT family
GN308_RS14240	COG0805	protein transport
GN308_RS14245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GN308_RS14265	COG2855	membrane
GN308_RS14270	COG0583	DNA-binding transcription factor activity
GN308_RS14280	COG0542	response to heat
GN308_RS14300	COG1862	Preprotein translocase
GN308_RS14305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GN308_RS14315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GN308_RS14320	COG0193	aminoacyl-tRNA hydrolase activity
GN308_RS14325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GN308_RS14335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GN308_RS14335	COG4651	solute:proton antiporter activity
GN308_RS14340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GN308_RS14345	COG2195	Cleaves the N-terminal amino acid of tripeptides
GN308_RS14350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GN308_RS14355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GN308_RS14365	COG0745	RESPONSE REGULATOR receiver
GN308_RS14365	COG2205	protein histidine kinase activity
GN308_RS14365	COG3292	Two component regulator propeller
GN308_RS14380	COG5146	pantothenate kinase activity
GN308_RS14460	COG0656	L-ascorbic acid biosynthetic process
GN308_RS14465	COG0656	L-ascorbic acid biosynthetic process
GN308_RS14470	COG3250	beta-galactosidase activity
GN308_RS14530	COG0805	protein transport
GN308_RS14535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GN308_RS14550	COG0655	NAD(P)H dehydrogenase (quinone) activity
GN308_RS14575	COG0667	Aldo Keto reductase
GN308_RS14580	COG2311	Membrane
GN308_RS14585	COG0697	spore germination
GN308_RS14600	COG0667	Aldo Keto reductase
GN308_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS14635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GN308_RS14640	COG0534	Mate efflux family protein
GN308_RS14665	COG0656	L-ascorbic acid biosynthetic process
GN308_RS14675	COG0667	Aldo Keto reductase
GN308_RS14730	COG3708	Transcriptional regulator
GN308_RS14730	COG2207	Transcriptional regulator
GN308_RS14735	COG1917	Cupin 2, conserved barrel domain protein
GN308_RS14735	COG4977	sequence-specific DNA binding
GN308_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS14750	COG0671	phosphoesterase, PA-phosphatase related
GN308_RS14755	COG3850	Histidine kinase
GN308_RS14755	COG5002	protein histidine kinase activity
GN308_RS14760	COG0745	RESPONSE REGULATOR receiver
GN308_RS14840	COG3385	transposase activity
GN308_RS14970	COG4974	Belongs to the 'phage' integrase family
GN308_RS14990	COG4974	Belongs to the 'phage' integrase family
GN308_RS15010	COG0788	formyltetrahydrofolate deformylase activity
GN308_RS15020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GN308_RS15025	COG0107	imidazoleglycerol-phosphate synthase activity
GN308_RS15030	COG0140	phosphoribosyl-ATP diphosphatase activity
GN308_RS15030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GN308_RS15035	COG2884	Cell division ATP-binding protein ftsE
GN308_RS15040	COG0527	aspartate kinase activity
GN308_RS15045	COG0019	diaminopimelate decarboxylase activity
GN308_RS15070	COG2431	L-lysine efflux transmembrane transporter activity
GN308_RS15080	COG0436	Aminotransferase
GN308_RS15095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GN308_RS15100	COG0167	dihydroorotate dehydrogenase activity
GN308_RS15150	COG1027	Aspartate ammonia-lyase
GN308_RS15155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GN308_RS15165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GN308_RS15175	COG4657	Part of a membrane complex involved in electron transport
GN308_RS15180	COG4660	Part of a membrane complex involved in electron transport
GN308_RS15185	COG4659	FMN binding
GN308_RS15190	COG4658	electron transport chain
GN308_RS15195	COG4656	Part of a membrane complex involved in electron transport
GN308_RS15210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GN308_RS15215	COG0697	spore germination
GN308_RS15225	COG0076	glutamate decarboxylase activity
GN308_RS15230	COG2066	Belongs to the glutaminase family
GN308_RS15235	COG3142	Participates in the control of copper homeostasis
GN308_RS15255	COG0531	amino acid
GN308_RS15260	COG5002	protein histidine kinase activity
GN308_RS15265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GN308_RS15270	COG0481	GTPase activity
GN308_RS15290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GN308_RS15295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GN308_RS15355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GN308_RS15370	COG3475	LICD family
GN308_RS15380	COG3392	D12 class N6 adenine-specific DNA methyltransferase
GN308_RS15465	COG0740	serine-type endopeptidase activity
GN308_RS15625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GN308_RS15690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GN308_RS15695	COG0581	inorganic phosphate transmembrane transporter activity
GN308_RS15700	COG0573	inorganic phosphate transmembrane transporter activity
GN308_RS15705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GN308_RS15710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GN308_RS15725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GN308_RS15730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS15735	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GN308_RS15745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN308_RS15770	COG2115	Belongs to the xylose isomerase family
GN308_RS15785	COG0745	RESPONSE REGULATOR receiver
GN308_RS15785	COG2205	protein histidine kinase activity
GN308_RS15785	COG3292	Two component regulator propeller
GN308_RS15790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GN308_RS15810	COG1215	transferase activity, transferring glycosyl groups
GN308_RS15835	COG1216	Glycosyl transferase, family 2
GN308_RS15840	COG1216	Glycosyl transferase, family 2
GN308_RS15860	COG0438	transferase activity, transferring glycosyl groups
GN308_RS15870	COG1215	transferase activity, transferring glycosyl groups
GN308_RS15890	COG0438	transferase activity, transferring glycosyl groups
GN308_RS15900	COG1216	Glycosyl transferase, family 2
GN308_RS15900	COG1442	glycosyl transferase family 8
GN308_RS15910	COG0463	Glycosyl transferase, family 2
GN308_RS15915	COG0745	RESPONSE REGULATOR receiver
GN308_RS15920	COG2205	protein histidine kinase activity
GN308_RS15920	COG0784	Response regulator, receiver
GN308_RS15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GN308_RS15940	COG0351	phosphomethylpyrimidine kinase
GN308_RS15940	COG0352	thiamine-phosphate diphosphorylase activity
GN308_RS15945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GN308_RS15955	COG0366	Alpha amylase catalytic
GN308_RS15970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GN308_RS15975	COG0071	Belongs to the small heat shock protein (HSP20) family
GN308_RS15990	COG0505	Belongs to the CarA family
GN308_RS16000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GN308_RS16005	COG0067	glutamate synthase
GN308_RS16005	COG0069	glutamate synthase activity
GN308_RS16005	COG0070	glutamate synthase
GN308_RS16015	COG0367	asparagine synthase
GN308_RS16050	COG2197	response regulator
GN308_RS16510	COG4974	Belongs to the 'phage' integrase family
GN308_RS16525	COG3646	Phage regulatory protein
GN308_RS16620	COG1895	HEPN domain
GN308_RS16665	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GN308_RS16670	COG1216	Glycosyl transferase, family 2
GN308_RS16705	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GN308_RS16740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GN308_RS16745	COG1083	cytidylyl-transferase
GN308_RS16750	COG2089	acid synthase
GN308_RS16765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GN308_RS16770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GN308_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS16790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GN308_RS16855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GN308_RS16865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GN308_RS16870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GN308_RS16875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GN308_RS16880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GN308_RS16890	COG0242	peptide deformylase activity
GN308_RS16895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GN308_RS16940	COG4946	Tricorn protease homolog
GN308_RS16940	COG0823	Involved in the tonB-independent uptake of proteins
GN308_RS16940	COG1506	peptidase
GN308_RS16945	COG2814	Major facilitator Superfamily
GN308_RS16945	COG0477	Major facilitator Superfamily
GN308_RS16970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS17000	COG0133	tryptophan synthase activity
GN308_RS17005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GN308_RS17010	COG0512	Glutamine amidotransferase of anthranilate synthase
GN308_RS17015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GN308_RS17020	COG0134	indole-3-glycerol-phosphate synthase activity
GN308_RS17025	COG0135	phosphoribosylanthranilate isomerase activity
GN308_RS17030	COG0159	tryptophan synthase activity
GN308_RS17035	COG0252	asparaginase activity
GN308_RS17040	COG0745	RESPONSE REGULATOR receiver
GN308_RS17045	COG5002	protein histidine kinase activity
GN308_RS17060	COG0629	single-stranded DNA binding
GN308_RS17070	COG0776	regulation of translation
GN308_RS17075	COG1530	ribonuclease E activity
GN308_RS17085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GN308_RS17095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GN308_RS17100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GN308_RS17105	COG0166	Belongs to the GPI family
GN308_RS17110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GN308_RS17120	COG0702	epimerase
GN308_RS17125	COG4771	TonB-dependent receptor
GN308_RS17140	COG1940	carbohydrate kinase activity
GN308_RS17155	COG2271	Major facilitator Superfamily
GN308_RS17160	COG0363	glucosamine-6-phosphate deaminase activity
GN308_RS17165	COG0363	glucosamine-6-phosphate deaminase activity
GN308_RS17175	COG1917	Cupin 2, conserved barrel domain protein
GN308_RS17175	COG4977	sequence-specific DNA binding
GN308_RS17240	COG0745	RESPONSE REGULATOR receiver
GN308_RS17250	COG3250	beta-galactosidase activity
GN308_RS17260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS17270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS17290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS17305	COG1629	transport
GN308_RS17305	COG4206	TonB-dependent receptor
GN308_RS17315	COG2502	aspartate--ammonia ligase
GN308_RS17320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GN308_RS17335	COG3876	Protein conserved in bacteria
GN308_RS17390	COG0732	type I restriction modification DNA specificity domain
GN308_RS17400	COG0732	type I restriction modification DNA specificity domain
GN308_RS17405	COG4804	nuclease activity
GN308_RS17410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GN308_RS17440	COG3385	transposase activity
GN308_RS17490	COG0860	N-Acetylmuramoyl-L-alanine amidase
GN308_RS17500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GN308_RS17505	COG0778	Nitroreductase
GN308_RS17520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GN308_RS17535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GN308_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
GN308_RS17550	COG0359	binds to the 23S rRNA
GN308_RS17555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GN308_RS17560	COG0360	Binds together with S18 to 16S ribosomal RNA
GN308_RS17585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GN308_RS17590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GN308_RS17640	COG3661	Belongs to the glycosyl hydrolase 67 family
GN308_RS17650	COG3507	Belongs to the glycosyl hydrolase 43 family
GN308_RS17655	COG0745	RESPONSE REGULATOR receiver
GN308_RS17655	COG3292	Two component regulator propeller
GN308_RS17655	COG2205	protein histidine kinase activity
GN308_RS17665	COG1629	transport
GN308_RS17665	COG4206	TonB-dependent receptor
GN308_RS17670	COG3507	Belongs to the glycosyl hydrolase 43 family
GN308_RS17685	COG2211	Major facilitator Superfamily
GN308_RS17695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GN308_RS17705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GN308_RS17710	COG2333	competence protein COMEC
GN308_RS17710	COG0658	competence protein
GN308_RS17715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GN308_RS17735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GN308_RS17745	COG0009	L-threonylcarbamoyladenylate synthase
GN308_RS17760	COG4771	TonB-dependent receptor
GN308_RS17770	COG2205	protein histidine kinase activity
GN308_RS17770	COG0745	RESPONSE REGULATOR receiver
GN308_RS17770	COG3292	Two component regulator propeller
GN308_RS17770	COG0745	RESPONSE REGULATOR receiver
GN308_RS17770	COG3292	Two component regulator propeller
GN308_RS17770	COG2205	protein histidine kinase activity
GN308_RS17775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GN308_RS17810	COG0681	Belongs to the peptidase S26 family
GN308_RS17875	COG0745	RESPONSE REGULATOR receiver
GN308_RS17875	COG2205	protein histidine kinase activity
GN308_RS17875	COG3292	Two component regulator propeller
GN308_RS17895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GN308_RS17910	COG1280	lysine exporter protein (LysE YggA)
GN308_RS17915	COG0047	phosphoribosylformylglycinamidine synthase activity
GN308_RS17915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GN308_RS17920	COG0745	RESPONSE REGULATOR receiver
GN308_RS17920	COG3292	Two component regulator propeller
GN308_RS17920	COG2205	protein histidine kinase activity
GN308_RS17925	COG2059	Chromate
GN308_RS17940	COG1501	Belongs to the glycosyl hydrolase 31 family
GN308_RS17945	COG1649	PFAM Uncharacterised BCR, COG1649
GN308_RS17960	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS17975	COG1966	Carbon starvation protein
GN308_RS17985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GN308_RS17990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GN308_RS17995	COG0284	orotidine-5'-phosphate decarboxylase activity
GN308_RS18000	COG1078	dGTPase activity
GN308_RS18005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN308_RS18010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GN308_RS18010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GN308_RS18015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN308_RS18025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GN308_RS18045	COG0386	Belongs to the glutathione peroxidase family
GN308_RS18055	COG1629	transport
GN308_RS18055	COG4206	TonB-dependent receptor
GN308_RS18065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS18075	COG4948	Mandelate Racemase Muconate Lactonizing
GN308_RS18100	COG2267	carboxylic ester hydrolase activity
GN308_RS18110	COG3940	Belongs to the glycosyl hydrolase 43 family
GN308_RS18160	COG4206	TonB-dependent receptor
GN308_RS18160	COG1629	transport
GN308_RS18165	COG1595	DNA-templated transcription, initiation
GN308_RS18180	COG3250	beta-galactosidase activity
GN308_RS18195	COG1472	Belongs to the glycosyl hydrolase 3 family
GN308_RS18205	COG4948	Mandelate Racemase Muconate Lactonizing
GN308_RS18215	COG0702	epimerase
GN308_RS18220	COG1629	transport
GN308_RS18230	COG1082	Xylose isomerase domain protein TIM barrel
GN308_RS18240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS18245	COG2205	protein histidine kinase activity
GN308_RS18245	COG3292	Two component regulator propeller
GN308_RS18245	COG0745	RESPONSE REGULATOR receiver
GN308_RS18270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN308_RS18270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN308_RS18275	COG0436	Aminotransferase
GN308_RS18285	COG1472	Belongs to the glycosyl hydrolase 3 family
GN308_RS18290	COG0737	Belongs to the 5'-nucleotidase family
GN308_RS18295	COG0737	Belongs to the 5'-nucleotidase family
GN308_RS18300	COG0335	large ribosomal subunit rRNA binding
GN308_RS18305	COG0745	RESPONSE REGULATOR receiver
GN308_RS18305	COG2205	protein histidine kinase activity
GN308_RS18305	COG3292	Two component regulator propeller
GN308_RS18310	COG3254	rhamnose metabolic process
GN308_RS18315	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GN308_RS18320	COG3401	FG-GAP repeat protein
GN308_RS18350	COG0702	epimerase
GN308_RS18355	COG4771	TonB-dependent receptor
GN308_RS18375	COG2755	lipolytic protein G-D-S-L family
GN308_RS18380	COG3401	FG-GAP repeat protein
GN308_RS18385	COG3250	beta-galactosidase activity
GN308_RS18395	COG3119	arylsulfatase activity
GN308_RS18410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS18415	COG4206	TonB-dependent receptor
GN308_RS18415	COG1629	transport
GN308_RS18425	COG4771	TonB-dependent receptor
GN308_RS18435	COG4206	TonB-dependent receptor
GN308_RS18435	COG1629	transport
GN308_RS18450	COG4771	TonB-dependent receptor
GN308_RS18475	COG3401	FG-GAP repeat protein
GN308_RS18490	COG1874	Beta-galactosidase
GN308_RS18500	COG3250	beta-galactosidase activity
GN308_RS18505	COG2755	lipolytic protein G-D-S-L family
GN308_RS18545	COG3254	rhamnose metabolic process
GN308_RS18550	COG1940	carbohydrate kinase activity
GN308_RS18555	COG1136	(ABC) transporter
GN308_RS18560	COG0577	efflux transmembrane transporter activity
GN308_RS18560	COG1136	(ABC) transporter
GN308_RS18565	COG1136	(ABC) transporter
GN308_RS18565	COG0577	efflux transmembrane transporter activity
GN308_RS18585	COG2996	Protein conserved in bacteria
GN308_RS18590	COG1979	alcohol dehydrogenase
GN308_RS18600	COG1136	(ABC) transporter
GN308_RS18605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GN308_RS18610	COG0475	glutathione-regulated potassium exporter activity
GN308_RS18610	COG0589	response to stress
GN308_RS18615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GN308_RS18625	COG0423	glycine-tRNA ligase activity
GN308_RS18655	COG0702	epimerase
GN308_RS18660	COG1629	transport
GN308_RS18670	COG2207	Transcriptional regulator
GN308_RS18685	COG0738	Major facilitator superfamily
GN308_RS18690	COG1063	alcohol dehydrogenase
GN308_RS18695	COG2095	MarC family integral membrane protein
GN308_RS18730	COG1696	Membrane protein involved in D-alanine export
GN308_RS18755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS18795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GN308_RS18835	COG3969	phosphoadenosine phosphosulfate
GN308_RS18840	COG1475	DNA binding
GN308_RS18850	COG0039	L-malate dehydrogenase activity
GN308_RS18865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GN308_RS18880	COG3015	lipoprotein NlpE involved in copper resistance
GN308_RS18895	COG0489	protein tyrosine kinase activity
GN308_RS18910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GN308_RS18915	COG1722	exodeoxyribonuclease VII activity
GN308_RS18920	COG1570	exodeoxyribonuclease VII activity
GN308_RS18930	COG0534	Mate efflux family protein
GN308_RS19065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GN308_RS19075	COG1088	dTDP-glucose 4,6-dehydratase activity
GN308_RS19080	COG1629	transport
GN308_RS19090	COG3250	beta-galactosidase activity
GN308_RS19095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GN308_RS19095	COG3408	Glycogen debranching enzyme
GN308_RS19100	COG0702	epimerase
GN308_RS19105	COG4771	TonB-dependent receptor
GN308_RS19120	COG0488	(ABC) transporter
GN308_RS19125	COG0569	domain protein
GN308_RS19125	COG2985	domain, Protein
GN308_RS19130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN308_RS19135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN308_RS19135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GN308_RS19145	COG1629	transport
GN308_RS19160	COG2205	protein histidine kinase activity
GN308_RS19165	COG0668	transmembrane transport
GN308_RS19190	COG0681	Belongs to the peptidase S26 family
GN308_RS19205	COG2086	electron transfer activity
GN308_RS19210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GN308_RS19230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GN308_RS19240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GN308_RS19250	COG4804	nuclease activity
GN308_RS19265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GN308_RS19275	COG1228	amidohydrolase
GN308_RS19280	COG3404	Formiminotransferase-cyclodeaminase
GN308_RS19285	COG2986	histidine ammonia-lyase
GN308_RS19290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GN308_RS19300	COG0693	protein deglycase activity
GN308_RS19320	COG0673	inositol 2-dehydrogenase activity
GN308_RS19325	COG0288	reversible hydration of carbon dioxide
GN308_RS19345	COG0459	protein refolding
GN308_RS19350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GN308_RS19360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GN308_RS19370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GN308_RS19375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GN308_RS19380	COG1518	maintenance of DNA repeat elements
GN308_RS19410	COG1203	CRISPR-associated helicase, Cas3
GN308_RS19415	COG0124	histidyl-tRNA synthetase
GN308_RS19420	COG1879	ABC-type sugar transport system periplasmic component
GN308_RS19435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GN308_RS19440	COG3958	Transketolase
GN308_RS19445	COG3959	Transketolase, thiamine diphosphate binding domain
GN308_RS19450	COG1349	DNA-binding transcription factor activity
GN308_RS19455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN308_RS19455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GN308_RS19465	COG2205	protein histidine kinase activity
GN308_RS19465	COG0745	RESPONSE REGULATOR receiver
GN308_RS19465	COG3292	Two component regulator propeller
GN308_RS19465	COG2205	protein histidine kinase activity
GN308_RS19465	COG0745	RESPONSE REGULATOR receiver
GN308_RS19465	COG3292	Two component regulator propeller
GN308_RS19475	COG1629	transport
GN308_RS19550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GN308_RS19560	COG0534	Mate efflux family protein
GN308_RS19565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN308_RS19565	COG2205	protein histidine kinase activity
GN308_RS19565	COG0784	Response regulator, receiver
GN308_RS19565	COG2198	Histidine kinase
GN308_RS19570	COG2204	response regulator
GN308_RS19580	COG0564	pseudouridine synthase activity
GN308_RS19585	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS19600	COG3250	beta-galactosidase activity
GN308_RS19620	COG1629	transport
GN308_RS19620	COG4206	TonB-dependent receptor
GN308_RS19625	COG0513	Belongs to the DEAD box helicase family
GN308_RS19645	COG0482	sulfurtransferase activity
GN308_RS19650	COG2197	response regulator
GN308_RS19680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GN308_RS19695	COG3022	response to hydroperoxide
GN308_RS19700	COG2885	chlorophyll binding
GN308_RS19710	COG2895	sulfate adenylyltransferase (ATP) activity
GN308_RS19715	COG0175	sulfate reduction
GN308_RS19720	COG0529	Catalyzes the synthesis of activated sulfate
GN308_RS19725	COG0471	metal ion transport
GN308_RS19725	COG3273	potassium ion transport
GN308_RS19730	COG1218	3'(2'),5'-bisphosphate nucleotidase
GN308_RS19740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GN308_RS19770	COG0517	IMP dehydrogenase activity
GN308_RS19770	COG0516	GMP reductase activity
GN308_RS19780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GN308_RS19785	COG0740	serine-type endopeptidase activity
GN308_RS19790	COG0544	peptidyl-prolyl cis-trans isomerase activity
GN308_RS19795	COG0724	RNA recognition motif
GN308_RS19805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GN308_RS19810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GN308_RS19815	COG1160	GTP binding
GN308_RS19820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GN308_RS19825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GN308_RS19880	COG0039	L-malate dehydrogenase activity
GN308_RS19885	COG0358	DNA primase activity
GN308_RS19890	COG0302	gtp cyclohydrolase
GN308_RS19910	COG0739	heme binding
GN308_RS19915	COG0105	UTP biosynthetic process
GN308_RS19920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GN308_RS19925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GN308_RS19940	COG0848	biopolymer transport protein
GN308_RS19945	COG0811	peptide transport
GN308_RS19950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GN308_RS19955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GN308_RS20000	COG0420	3'-5' exonuclease activity
GN308_RS20010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS20015	COG4206	TonB-dependent receptor
GN308_RS20015	COG1629	transport
GN308_RS20020	COG4977	sequence-specific DNA binding
GN308_RS20040	COG3408	Glycogen debranching enzyme
GN308_RS20045	COG0702	epimerase
GN308_RS20050	COG4771	TonB-dependent receptor
GN308_RS20065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GN308_RS20070	COG4771	TonB-dependent receptor
GN308_RS20075	COG0702	epimerase
GN308_RS20090	COG3507	Belongs to the glycosyl hydrolase 43 family
GN308_RS20100	COG4771	TonB-dependent receptor
GN308_RS20110	COG1629	transport
GN308_RS20110	COG4206	TonB-dependent receptor
GN308_RS20115	COG2205	protein histidine kinase activity
GN308_RS20115	COG3292	Two component regulator propeller
GN308_RS20115	COG0745	RESPONSE REGULATOR receiver
GN308_RS20135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GN308_RS20140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GN308_RS20145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GN308_RS20160	COG1346	cytolysis
GN308_RS20170	COG0280	phosphate acetyltransferase
GN308_RS20175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GN308_RS20180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GN308_RS20185	COG2151	metal-sulfur cluster biosynthetic enzyme
GN308_RS20190	COG2003	Belongs to the UPF0758 family
GN308_RS20195	COG1216	Glycosyl transferase, family 2
GN308_RS20195	COG0463	Glycosyl transferase, family 2
GN308_RS20200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GN308_RS20205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GN308_RS20210	COG0641	radical SAM
GN308_RS20240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GN308_RS20245	COG3119	arylsulfatase activity
GN308_RS20250	COG0702	epimerase
GN308_RS20255	COG4771	TonB-dependent receptor
GN308_RS20260	COG2755	lipolytic protein G-D-S-L family
GN308_RS20260	COG0657	acetylesterase activity
GN308_RS20265	COG0745	RESPONSE REGULATOR receiver
GN308_RS20265	COG2205	protein histidine kinase activity
GN308_RS20265	COG3292	Two component regulator propeller
GN308_RS20285	COG0564	pseudouridine synthase activity
GN308_RS20290	COG1181	Belongs to the D-alanine--D-alanine ligase family
GN308_RS20310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GN308_RS20315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GN308_RS20320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GN308_RS20325	COG0561	phosphatase activity
GN308_RS20350	COG1629	transport
GN308_RS20350	COG4206	TonB-dependent receptor
GN308_RS20360	COG4771	TonB-dependent receptor
GN308_RS20390	COG4206	TonB-dependent receptor
GN308_RS20390	COG1629	transport
GN308_RS20410	COG4206	TonB-dependent receptor
GN308_RS20410	COG1629	transport
GN308_RS20425	COG4206	TonB-dependent receptor
GN308_RS20425	COG1629	transport
GN308_RS20435	COG4206	TonB-dependent receptor
GN308_RS20435	COG1629	transport
GN308_RS20450	COG4206	TonB-dependent receptor
GN308_RS20450	COG1629	transport
GN308_RS20465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GN308_RS20470	COG1396	sequence-specific DNA binding
GN308_RS20470	COG1917	Cupin 2, conserved barrel domain protein
GN308_RS20485	COG0348	domain, Protein
GN308_RS20490	COG0667	Aldo Keto reductase
GN308_RS20495	COG1368	sulfuric ester hydrolase activity
GN308_RS20500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GN308_RS20505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GN308_RS20510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GN308_RS20515	COG0137	argininosuccinate synthase activity
GN308_RS20525	COG1438	arginine binding
GN308_RS20530	COG1070	Carbohydrate kinase
GN308_RS20535	COG4806	L-rhamnose isomerase
GN308_RS20545	COG0235	Class ii aldolase
GN308_RS20560	COG0702	epimerase
GN308_RS20565	COG1629	transport
GN308_RS20565	COG4206	TonB-dependent receptor
GN308_RS20570	COG0745	RESPONSE REGULATOR receiver
GN308_RS20570	COG2205	protein histidine kinase activity
GN308_RS20570	COG3292	Two component regulator propeller
GN308_RS20580	COG1388	LysM domain
GN308_RS20580	COG0741	lytic transglycosylase activity
GN308_RS20585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GN308_RS20590	COG3250	beta-galactosidase activity
GN308_RS20610	COG0673	inositol 2-dehydrogenase activity
GN308_RS20625	COG0656	L-ascorbic acid biosynthetic process
GN308_RS20630	COG0656	L-ascorbic acid biosynthetic process
GN308_RS20635	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS20640	COG2249	NAD(P)H dehydrogenase (quinone) activity
GN308_RS20645	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GN308_RS20655	COG1082	Xylose isomerase domain protein TIM barrel
GN308_RS20675	COG4771	TonB-dependent receptor
GN308_RS20680	COG3537	Alpha-1,2-mannosidase
GN308_RS20710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GN308_RS20715	COG0542	response to heat
GN308_RS20720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GN308_RS20740	COG2197	response regulator
GN308_RS20745	COG3345	alpha-galactosidase
GN308_RS20750	COG4974	Belongs to the 'phage' integrase family
GN308_RS20800	COG0561	phosphatase activity
GN308_RS20805	COG4771	TonB-dependent receptor
GN308_RS20850	COG0702	epimerase
GN308_RS20855	COG1629	transport
GN308_RS20865	COG2205	protein histidine kinase activity
GN308_RS20865	COG2205	protein histidine kinase activity
GN308_RS20865	COG3292	Two component regulator propeller
GN308_RS20865	COG0745	RESPONSE REGULATOR receiver
GN308_RS20865	COG0745	RESPONSE REGULATOR receiver
GN308_RS20865	COG3292	Two component regulator propeller
GN308_RS20870	COG4948	Mandelate Racemase Muconate Lactonizing
GN308_RS20875	COG0457	Tetratricopeptide repeat
GN308_RS20880	COG2814	Major facilitator Superfamily
GN308_RS20890	COG3537	Alpha-1,2-mannosidase
GN308_RS20895	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GN308_RS20895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GN308_RS20945	COG2873	o-acetylhomoserine
GN308_RS20960	COG1595	DNA-templated transcription, initiation
GN308_RS20995	COG0203	ribosomal protein L17
GN308_RS21000	COG0202	RNA polymerase activity
GN308_RS21005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GN308_RS21010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GN308_RS21015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GN308_RS21020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GN308_RS21025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GN308_RS21040	COG0200	Binds to the 23S rRNA
GN308_RS21045	COG1841	ribosomal large subunit assembly
GN308_RS21050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GN308_RS21055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GN308_RS21060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GN308_RS21065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GN308_RS21070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GN308_RS21075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GN308_RS21080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GN308_RS21085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GN308_RS21090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GN308_RS21095	COG0255	Belongs to the universal ribosomal protein uL29 family
GN308_RS21100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GN308_RS21105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GN308_RS21110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GN308_RS21115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GN308_RS21120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GN308_RS21125	COG0089	rRNA binding
GN308_RS21130	COG0088	Forms part of the polypeptide exit tunnel
GN308_RS21135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GN308_RS21140	COG0051	transcription antitermination factor activity, RNA binding
GN308_RS21145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GN308_RS21150	COG0049	tRNA binding
GN308_RS21155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GN308_RS21165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GN308_RS21170	COG0085	RNA polymerase activity
GN308_RS21175	COG0222	ribosome binding
GN308_RS21180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GN308_RS21185	COG0081	regulation of translation
GN308_RS21190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GN308_RS21210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GN308_RS21240	COG4974	Belongs to the 'phage' integrase family
GN308_RS21245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GN308_RS21255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GN308_RS21275	COG0745	RESPONSE REGULATOR receiver
GN308_RS21280	COG5002	protein histidine kinase activity
GN308_RS21290	COG0793	Belongs to the peptidase S41A family
GN308_RS21295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GN308_RS21325	COG1629	transport
GN308_RS21325	COG4206	TonB-dependent receptor
GN308_RS21330	COG0702	epimerase
GN308_RS21335	COG0584	glycerophosphoryl diester phosphodiesterase
GN308_RS21340	COG3537	Alpha-1,2-mannosidase
GN308_RS21360	COG0745	RESPONSE REGULATOR receiver
GN308_RS21360	COG2205	protein histidine kinase activity
GN308_RS21360	COG3292	Two component regulator propeller
GN308_RS21365	COG4206	TonB-dependent receptor
GN308_RS21365	COG1629	transport
GN308_RS21370	COG0702	epimerase
GN308_RS21385	COG1609	Transcriptional regulator
GN308_RS21390	COG3634	alkyl hydroperoxide reductase activity
GN308_RS21400	COG0148	phosphopyruvate hydratase activity
GN308_RS21425	COG3250	beta-galactosidase activity
GN308_RS21440	COG4206	TonB-dependent receptor
GN308_RS21440	COG1629	transport
GN308_RS21445	COG3292	Two component regulator propeller
GN308_RS21445	COG0745	RESPONSE REGULATOR receiver
GN308_RS21445	COG2205	protein histidine kinase activity
GN308_RS21485	COG3250	beta-galactosidase activity
GN308_RS21490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS21495	COG4771	TonB-dependent receptor
GN308_RS21500	COG2205	protein histidine kinase activity
GN308_RS21500	COG0745	RESPONSE REGULATOR receiver
GN308_RS21500	COG3292	Two component regulator propeller
GN308_RS21505	COG0519	Catalyzes the synthesis of GMP from XMP
GN308_RS21540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GN308_RS21550	COG1185	polyribonucleotide nucleotidyltransferase activity
GN308_RS21555	COG1773	rubredoxin
GN308_RS21560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GN308_RS21565	COG0545	Peptidyl-prolyl cis-trans isomerase
GN308_RS21570	COG0545	Peptidyl-prolyl cis-trans isomerase
GN308_RS21580	COG1283	sodium-dependent phosphate transmembrane transporter activity
GN308_RS21585	COG1283	sodium-dependent phosphate transmembrane transporter activity
GN308_RS21590	COG0572	uridine kinase
GN308_RS21610	COG0006	proline dipeptidase activity
GN308_RS21625	COG0509	glycine decarboxylation via glycine cleavage system
GN308_RS21630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GN308_RS21635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GN308_RS21640	COG2066	Belongs to the glutaminase family
GN308_RS21645	COG0724	RNA recognition motif
GN308_RS21665	COG3063	Type IV pilus biogenesis stability protein PilW
GN308_RS21670	COG0756	dUTP diphosphatase activity
GN308_RS21690	COG2001	Belongs to the MraZ family
GN308_RS21695	COG0275	rRNA processing
GN308_RS21705	COG0768	penicillin binding
GN308_RS21710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GN308_RS21715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GN308_RS21720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GN308_RS21725	COG0772	Belongs to the SEDS family
GN308_RS21730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GN308_RS21735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GN308_RS21750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GN308_RS21760	COG1381	Involved in DNA repair and RecF pathway recombination
GN308_RS21770	COG0268	Binds directly to 16S ribosomal RNA
GN308_RS21775	COG0187	DNA topoisomerase II activity
GN308_RS21780	COG1640	4-alpha-glucanotransferase
GN308_RS21805	COG3385	transposase activity
GN308_RS21825	COG0366	Alpha amylase catalytic
GN308_RS21830	COG1082	Xylose isomerase domain protein TIM barrel
GN308_RS21840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS21850	COG1629	transport
GN308_RS21850	COG4206	TonB-dependent receptor
GN308_RS21855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GN308_RS21870	COG0366	Alpha amylase catalytic
GN308_RS21900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GN308_RS21910	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
GN308_RS21915	COG0738	Major facilitator superfamily
GN308_RS21920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GN308_RS21930	COG4206	TonB-dependent receptor
GN308_RS21930	COG1629	transport
GN308_RS21935	COG0702	epimerase
GN308_RS21945	COG2431	L-lysine efflux transmembrane transporter activity
GN308_RS21950	COG3250	beta-galactosidase activity
GN308_RS21955	COG3408	Glycogen debranching enzyme
GN308_RS21955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GN308_RS21960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GN308_RS21965	COG0719	Fe-S assembly protein
GN308_RS21970	COG0396	ATPase activity
GN308_RS21975	COG0719	Fe-S assembly protein
GN308_RS21985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GN308_RS21990	COG0195	Participates in both transcription termination and antitermination
GN308_RS21995	COG0779	Required for maturation of 30S ribosomal subunits
GN308_RS22005	COG2814	Major facilitator Superfamily
GN308_RS22050	COG3458	cephalosporin-C deacetylase activity
GN308_RS22070	COG1595	DNA-templated transcription, initiation
GN308_RS22075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GN308_RS22080	COG1166	arginine decarboxylase activity
GN308_RS22085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GN308_RS22110	COG1253	flavin adenine dinucleotide binding
GN308_RS22120	COG1522	sequence-specific DNA binding
GN308_RS22145	COG3426	butyrate kinase activity
GN308_RS22150	COG0280	phosphate acetyltransferase
GN308_RS22155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GN308_RS22165	COG2166	iron-sulfur cluster assembly
GN308_RS22190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GN308_RS22290	COG4974	Belongs to the 'phage' integrase family
GN308_RS22295	COG0732	type I restriction modification DNA specificity domain
GN308_RS22340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GN308_RS22345	COG1011	Hydrolase
GN308_RS22350	COG0196	riboflavin kinase activity
GN308_RS22385	COG3655	Transcriptional regulator
GN308_RS22410	COG3591	Belongs to the peptidase S1B family
GN308_RS22425	COG2255	four-way junction helicase activity
GN308_RS22430	COG4974	Belongs to the 'phage' integrase family
GN308_RS22560	COG0482	sulfurtransferase activity
GN308_RS22565	COG0308	aminopeptidase N
GN308_RS22580	COG0517	IMP dehydrogenase activity
GN308_RS22580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GN308_RS22590	COG0612	Peptidase, M16
GN308_RS22600	COG0784	Response regulator, receiver
GN308_RS22600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GN308_RS22600	COG2198	Histidine kinase
GN308_RS22600	COG2205	protein histidine kinase activity
GN308_RS22605	COG3119	arylsulfatase activity
GN308_RS22615	COG4771	TonB-dependent receptor
GN308_RS22620	COG1312	Catalyzes the dehydration of D-mannonate
GN308_RS22625	COG1028	Short-chain dehydrogenase reductase Sdr
GN308_RS22635	COG0681	Belongs to the peptidase S26 family
GN308_RS22640	COG0681	Belongs to the peptidase S26 family
GN308_RS22645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GN308_RS22660	COG0584	glycerophosphoryl diester phosphodiesterase
GN308_RS22670	COG1454	alcohol dehydrogenase
GN308_RS22690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GN308_RS22690	COG0758	DNA mediated transformation
GN308_RS22755	COG1053	succinate dehydrogenase
GN308_RS22770	COG0793	Belongs to the peptidase S41A family
GN308_RS22770	COG3409	Peptidoglycan-binding domain 1 protein
GN308_RS22775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GN308_RS22840	COG0700	Nucleoside recognition
GN308_RS22845	COG5002	protein histidine kinase activity
GN308_RS22850	COG0745	RESPONSE REGULATOR receiver
GN308_RS22870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GN308_RS22880	COG2268	Band 7 protein
GN308_RS22885	COG0445	tRNA wobble uridine modification